FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Parellada, M
   Boada, L
   Moreno, C
   Llorente, C
   Romo, J
   Muela, C
   Arango, C
AF Parellada, M.
   Boada, L.
   Moreno, C.
   Llorente, C.
   Romo, J.
   Muela, C.
   Arango, C.
TI Specialty Care Programme for autism spectrum disorders in an urban
   population: A case-management model for health care delivery in an ASD
   population
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE Autism; Quality of care; Psychiatry in Europe
ID ASPERGER-SYNDROME; MENTAL-HEALTH; CHILDREN; SERVICES; ACCESS; ADULTS;
   DIAGNOSIS; ABNORMALITIES; ADOLESCENTS; PREVALENCE
AB Subjects with autism spectrum disorders (ASD) have more medical needs and more difficulties accessing health care services than the general population. Their verbal and non-verbal communication difficulties and particular behaviors, along with lack of expertise on the part of physicians and failure of the services to make adjustments, make it difficult for them to obtain an appropriate health care.
   Purpose: To describe a model for health care delivery in an ASD population.
   Method: Review of relevant literature and a discussion process with stakeholders leading to the design of a service to meet the specialty health needs of subjects of all ages with ASD for a region with a population of 6,000,000.
   Results: A service was designed centred around the concepts of case management, individualization, facilitation, accompaniment, continuous training and updating, and quality management. Five hundred and thirteen patients with ASD have been seen over a period of 18 months. The programme generated 1566 psychiatric visits and 1052 visits to other specialties (mainly Nutrition, Stomatology, Neurology, and Gastroenterology) in the same period.
   Conclusion: Persons with ASD may benefit from adjustments of health care services in order to improve their access to adequate health care at the quality level of the rest of the population. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Parellada, M.; Moreno, C.; Arango, C.] Hosp Gen Univ Gregorio Maranon, CIBERSAM, Ctr Invest Biomed Red Salud Mental, Dept Psychiat, Madrid, Spain.
   [Boada, L.; Llorente, C.; Romo, J.] Hosp Gen Univ Gregorio Maranon, Dept Psychiat, Madrid, Spain.
   [Muela, C.] Asociac Nuevo Horizonte, Madrid, Spain.
RP Parellada, M (reprint author), Hosp Gen Univ Gregorio Maranon, CIBERSAM, Ctr Invest Biomed Red Salud Mental, Dept Psychiat, Madrid, Spain.
EM parellada@hggm.es
CR Alvarez R, 2005, PERSONAS CON AUTISMO
   [Anonymous], 2001, DECALOGO CONCLUSION
   [Anonymous], 2001, ENCUESTA SATISFACCIO
   Autism Task Force, 2003, AUT SEARCH BRIGHT FU
   Bauman ML, 2010, NEUROTHERAPEUTICS, V7, P320, DOI 10.1016/j.nurt.2010.06.001
   Belinchon M., 2001, SITUACION NECESIDADE
   Brookman-Frazee LI, 2010, J AUTISM DEV DISORD, V40, P1188, DOI 10.1007/s10803-010-0976-0
   Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
   Burke LM, 2010, J PEDIATR ADOL GYNEC, V23, P11, DOI 10.1016/j.jpag.2009.04.005
   California-Department-of-Developmental-Services, 2002, AUT SPECTR DIS BEST
   Carr EG, 2007, J AUTISM DEV DISORD, V37, P413, DOI 10.1007/s10803-006-0176-0
   Coury D, 2009, CURR OPIN PEDIATR, V21, P828, DOI 10.1097/MOP.0b013e328331eaaa
   Couteur A, 2003, NATL AUTISM PLAN CHI
   Curtin Carol, 2005, BMC Pediatr, V5, P48, DOI 10.1186/1471-2431-5-48
   Denis D, 1997, J FR OPHTALMOL, V20, P103
   Dua V., 2003, STANDARDS GUIDELINES
   Ekinci O, 2010, EPILEPSY BEHAV, V17, P178, DOI 10.1016/j.yebeh.2009.11.014
   Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P1339, DOI 10.1007/s10803-009-0750-3
   Gerlai J, 2003, PHYSIOL BEHAV, V79, P461, DOI 10.1016/S0031-9384(03)00165-3
   Gillberg C, 2010, J AUTISM DEV DISORD, V40, P352, DOI 10.1007/s10803-009-0883-4
   Gillberg C, 2000, ACTA PSYCHIAT SCAND, V102, P321, DOI 10.1034/j.1600-0447.2000.102005321.x
   Golnik A, 2009, PEDIATRICS, V123, P966, DOI 10.1542/peds.2008-1321
   Hedley AA, 2004, JAMA-J AM MED ASSOC, V291, P2847, DOI 10.1001/jama.291.23.2847
   Herbert MR, 2005, NEUROSCIENTIST, V11, P417, DOI 10.1177/0091270005278866
   Horvath Karoly, 2002, Curr Gastroenterol Rep, V4, P251, DOI 10.1007/s11894-002-0071-6
   Ingudomnuku E, 2007, HORM BEHAV, V51, P597, DOI 10.1016/j.yhbeh.2007.02.001
   James S Jill, 2008, J Autism Dev Disord, V38, P1976, DOI 10.1007/s10803-008-0614-2
   Jordan R, 1998, GUIDE SERVICES CHILD
   Kogan MD, 2008, PEDIATRICS, V122, pE1149, DOI 10.1542/peds.2008-1057
   KONSTANTAREAS MM, 1987, J AUTISM DEV DISORD, V17, P585, DOI 10.1007/BF01486973
   Krakowiak P, 2008, J SLEEP RES, V17, P197, DOI 10.1111/j.1365-2869.2008.00650.x
   Krauss MW, 2003, MENT RETARD, V41, P329, DOI 10.1352/0047-6765(2003)41<329:ATSMCF>2.0.CO;2
   Kuehn BM, 2007, JAMA-J AM MED ASSOC, V297, P940, DOI 10.1001/jama.297.9.940
   Liptak GS, 2006, J AUTISM DEV DISORD, V36, P871, DOI 10.1007/s10803-006-0119-9
   Liptak GS, 2008, J DEV BEHAV PEDIATR, V29, P152, DOI 10.1097/DBP.0b013e318165c7a0
   Magalhaes ES, 2009, J NEUROIMMUNOL, V216, P108, DOI 10.1016/j.jneuroim.2009.09.015
   McConachie H, 2006, CHILD CARE HLTH DEV, V32, P553, DOI 10.1111/j.1365-2214.2006.00672.x
   Medical Research Council, 2001, REV AUT RES EP CAUS
   Merkes M, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-325
   Michel TM, 2010, FORTSCHR NEUROL PSYC, V78, P402, DOI 10.1055/s-0029-1245494
   Ming X, 2011, BMC HEALTH SERV RES, V11, DOI 10.1186/1472-6963-11-99
   Mouridsen SE, 2008, AUTISM, V12, P403, DOI 10.1177/1362361308091653
   Munoz J, 2004, YO AMBIEN DIGO 33 PR
   Paavonen EJ, 2008, J AUTISM DEV DISORD, V38, P41, DOI 10.1007/s10803-007-0360-x
   Parmeggiani A, 2010, BRAIN DEV-JPN, V32, P783, DOI 10.1016/j.braindev.2010.07.003
   Perry A., 2003, EVIDENCE BASED PRACT
   Renty J, 2006, AUTISM, V10, P511, DOI 10.1177/1362361306066604
   Roberts J. M., 2004, REV RES IDENTIFY MOS
   Rosenberg RE, 2010, J AUTISM DEV DISORD, V40, P342, DOI 10.1007/s10803-009-0878-1
   Ruble LA, 2005, J AUTISM DEV DISORD, V35, P3, DOI 10.1007/s10803-004-1026-6
   Saxena S, 2007, PSYCHIAT SERV, V58, P816, DOI 10.1176/appi.ps.58.6.816
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Vallejo P, 2007, INT J QUAL HEALTH C, V19, P74, DOI 10.1093/intqhc/mz1074
   Volkmar Fred, 1999, Journal of the American Academy of Child and Adolescent Psychiatry, V38, p32S
   Wille N, 2010, QUAL LIFE RES, V19, P875, DOI 10.1007/s11136-010-9648-y
NR 55
TC 3
Z9 3
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD FEB
PY 2013
VL 28
IS 2
BP 102
EP 109
DI 10.1016/j.eurpsy.2011.06.004
PG 8
WC Psychiatry
SC Psychiatry
GA 088XK
UT WOS:000314871000007
PM 21907549
ER

PT J
AU Berry, A
   Borgi, M
   Francia, N
   Alleva, E
   Cirulli, F
AF Berry, Alessandra
   Borgi, Marta
   Francia, Nadia
   Alleva, Enrico
   Cirulli, Francesca
TI Use of Assistance and Therapy Dogs for Children with Autism Spectrum
   Disorders: A Critical Review of the Current Evidence
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
ID PERVASIVE DEVELOPMENTAL DISORDERS; SERVICE DOGS; SOCIAL ACKNOWLEDGMENTS;
   SENSORY ABNORMALITIES; PRESCHOOL-CHILDREN; PARENTING STRESS;
   YOUNG-CHILDREN; BEHAVIOR; INTERVENTIONS; DISABILITIES
AB Background: Autism spectrum disorders (ASD) are characterized by deficits in social reciprocity and communication, and by unusually restricted, repetitive behaviors. Intervention strategies based on the exploitation of the emotional aspects of human-dog relationships hold the potential to overcome the difficulty of subjects with ASD to relate and interact effectively with others, targeting core symptoms of this disorder.
   Methods: This review summarizes the results of six published studies on the effects of brief interactions with dogs and the effects of introducing dogs in families with a child diagnosed with ASD, with an emphasis on social behaviors and language use. Furthermore, the possible mechanisms responsible for the beneficial effects observed are discussed.
   Conclusions: Although the studies described here are encouraging, further research with better designs and using larger samples is needed to strengthen translation of such interventions to the clinic. In addition, potential applications of analyzing child-dog interactions are highlighted to screen for early signs of the disorder.
C1 [Berry, Alessandra; Borgi, Marta; Francia, Nadia; Alleva, Enrico; Cirulli, Francesca] Ist Super Sanita, Sect Behav Neurosci, Dept Cell Biol & Neurosci, I-00161 Rome, Italy.
RP Cirulli, F (reprint author), Ist Super Sanita, Sect Behav Neurosci, Dept Cell Biol & Neurosci, Viale Regina Elena 299, I-00161 Rome, Italy.
EM francesca.cirulli@iss.it
FU Italian Ministry of Health (Italia-USA) [11US/11]; Istituto Superiore di
   Sanita; Azienda per i Servizi Sanitari Friuli Occidentale [6]
FX Funding for this study was provided by the Italian Ministry of Health
   (Italia-USA project 11US/11), Istituto Superiore di Sanita (Research
   project "Effects of dog-assisted therapies on physical and psychological
   well being in the institutionalized elderly"), and the Azienda per i
   Servizi Sanitari n. 6 Friuli Occidentale, collaborative project
   "Validazione di attivita innovative in ambito agricolo finalizzate
   all'inserimento sociale, riabilitativo e lavorativo di persone
   diversamente abili."
CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2
   Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Allen K, 2001, HYPERTENSION, V38, P815
   Allen K, 2002, PSYCHOSOM MED, V64, P727, DOI 10.1097/01.PSY.0000024236.11538.41
   Allen K, 1996, JAMA-J AM MED ASSOC, V275, P1001, DOI 10.1001/jama.275.13.1001
   ALLEN KM, 1991, J PERS SOC PSYCHOL, V61, P582, DOI 10.1037/0022-3514.61.4.582
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Bale TL, 2010, BIOL PSYCHIAT, V68, P314, DOI 10.1016/j.biopsych.2010.05.028
   Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
   Barker SB, 2010, ANTHROZOOS, V23, P79, DOI 10.2752/175303710X12627079939341
   Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081
   EDDY J, 1988, J PSYCHOL, V122, P39
   BRISKIN H, 1995, PEDIATR ANN, V24, P262
   Burrows KE, 2008, QUAL HEALTH RES, V18, P1642, DOI 10.1177/1049732308327088
   Burrows KE, 2008, J VET MED EDUC, V35, P559, DOI 10.3138/jvme.35.4.559
   Camp MM, 2001, AM J OCCUP THER, V55, P509
   Cirulli F, 2011, ANN I SUPER SANITA, V47, P341, DOI 10.4415/ANN_11_04_04
   Cotugno AJ, 2009, J AUTISM DEV DISORD, V39, P1268, DOI 10.1007/s10803-009-0741-4
   Davis BW, 2004, ANTHROZOOS, V17, P130
   Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
   DeSchriver MM, 1990, ANTHROZOOS, V4, P44, DOI DOI 10.2752/089279391787057396
   Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
   Esteves WS, 2008, ANTHROZOOS, V21, P5
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Friedmann E, 2007, ANTHROZOOS, V20, P51, DOI 10.2752/089279307780216605
   Friedmann E, 2009, VET CLIN N AM-SMALL, V39, P293, DOI 10.1016/j.cvsm.2008.10.015
   Friesen L., 2010, EARLY CHILDHOOD ED J, V37, P261, DOI DOI 10.1007/S10643-009-0349-5
   Granpeesheh D, 2009, ANN CLIN PSYCHIATRY, V21, P162
   Gray KM, 2001, J PAEDIATR CHILD H, V37, P221, DOI 10.1046/j.1440-1754.2001.00653.x
   Katcher A., 1983, NEW PERSPECTIVES OUR, P351
   Kellert SR, 1993, BEHAV NATURAL ENV, P241
   Klintwall L, 2011, RES DEV DISABIL, V32, P795, DOI 10.1016/j.ridd.2010.10.021
   KOLVIN I, 1971, BRIT J PSYCHIAT, V118, P381, DOI 10.1192/bjp.118.545.381
   Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
   Leskovec TJ, 2008, HARVARD REV PSYCHIAT, V16, P97, DOI 10.1080/10673220802075852
   Limond JA, 1997, ANTHROZOOS, V10, P84
   Liptak Gregory S, 2006, J Pediatr Health Care, V20, P245, DOI 10.1016/j.pedhc.2005.12.008
   FRIEDMANN E, 1993, ANTHROZOOS, V6, P115
   Lord C, 2011, NATURE, V474, P166, DOI 10.1038/474166a
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   MADER B, 1989, CHILD DEV, V60, P1529, DOI 10.1111/j.1467-8624.1989.tb04023.x
   Martin F, 2002, WESTERN J NURS RES, V24, P657, DOI 10.1177/019394502236639
   McNicholas J, 2000, BRIT J PSYCHOL, V91, P61, DOI 10.1348/000712600161673
   Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   Odendaal JSJ, 2003, VET J, V165, P296, DOI 10.1016/S1090-0233(02)00237-X
   O'Roak BJ, 2008, AUTISM RES, V1, P4, DOI 10.1002/aur.3
   Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
   Phetrasuwan S, 2009, J SPEC PEDIATR NURS, V14, P157, DOI 10.1111/j.1744-6155.2009.00188.x
   Prothmann A, 2005, ANTHROZOOS, V18, P43, DOI 10.2752/089279305785594261
   REDEFER LA, 1989, J AUTISM DEV DISORD, V19, P461, DOI 10.1007/BF02212943
   Reichow B, 2012, J AUTISM DEV DISORD, V42, P512, DOI 10.1007/s10803-011-1218-9
   Rogers S., 1988, J DIVISION EARLY CHI, V10, P135
   Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Rogers SJ, 1998, MENT RETARD DEV D R, V4, P104
   Sams MJ, 2006, AM J OCCUP THER, V60, P268
   Scherer SW, 2011, HUM GENET, V130, P123, DOI 10.1007/s00439-011-1037-2
   Serpell J., 1996, CO ANIMALS STUDY HUM
   Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116
   Silva K, 2011, J ALTERN COMPLEM MED, V17, P655, DOI 10.1089/acm.2010.0436
   Sivberg B, 2002, AUTISM, V6, P397, DOI 10.1177/1362361302006004006
   Smith M., 2008, PRESCHOOL ED PROGRAM, P65
   Solomon O, 2010, ETHOS, V38, P143, DOI 10.1111/j.1548-1352.2009.01085.x
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
   Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050
   Viau R, 2010, PSYCHONEUROENDOCRINO, V35, P1187, DOI 10.1016/j.psyneuen.2010.02.004
   Vismara LA, 2010, ANNU REV CLIN PSYCHO, V6, P447, DOI 10.1146/annurev.clinpsy.121208.131151
   Wiggins LD, 2009, J AUTISM DEV DISORD, V39, P1087, DOI 10.1007/s10803-009-0711-x
   World Health Organization, 1993, INT CLASS DIS DIAGN
   Young RL, 2003, AUTISM, V7, P125, DOI 10.1177/1362361303007002002
NR 74
TC 4
Z9 4
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD FEB
PY 2013
VL 19
IS 2
BP 73
EP 80
DI 10.1089/acm.2011.0835
PG 8
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 090KM
UT WOS:000314978000001
PM 22978246
ER

PT J
AU Heussler, H
   Chan, P
   Price, AMH
   Waters, K
   Davey, MJ
   Hiscock, H
AF Heussler, Helen
   Chan, Patrick
   Price, Anna M. H.
   Waters, Karen
   Davey, Margot J.
   Hiscock, Harriet
TI Pharmacological and non-pharmacological management of sleep disturbance
   in children: An Australian Paediatric Research Network survey
SO SLEEP MEDICINE
LA English
DT Article
DE Australian Paediatric Research Network; Behavior therapy; Melatonin;
   Paediatric; Sleep disorders
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS;
   HYPOGONADOTROPIC HYPOGONADISM; BEHAVIORAL INTERVENTIONS; EXOGENOUS
   MELATONIN; ONSET INSOMNIA; METAANALYSIS; PUBERTY; HEALTH
AB Background: Australian paediatricians use a wide variety of practices when managing sleep disturbances in children, including use of melatonin and behavioral strategies. However, practice patterns around the use of strategies, dosing, and how the patient populations managed, are unknown. Results could inform guidelines for the management of child sleep disturbances.
   Objective: We aimed to document management practices by Australian general paediatricians for paediatric sleep disturbances through an online survey sent to members of the Australian Paediatric Research Network (APRN) who are recruited from the Royal Australasian College of Physicians.
   Results: 181 (49%) of 373 eligible paediatricians responded, with 101 prescribing melatonin. The most commonly prescribed medications for poor sleep initiation were melatonin (89.1%), clonidine (48%) and antihistamines (29%). Melatonin doses ranged from 0.5 mg to 12 mg and duration of treatment was as long as 200 weeks. Less than half of the paediatricians were aware of any potential melatonin side effects. Most paediatricians (82%) reported using behavioral strategies for sleep disturbances, most commonly anxiety relaxation techniques (75%) for poor sleep initiation and graduated extinction (i.e. "controlled crying", 52%) for disrupted overnight sleep.
   Conclusions: Australian paediatricians use both pharmacological and non-pharmacological treatments for paediatric sleep disturbances. Melatonin is the most commonly prescribed medication, but wide variation in its prescribing suggests a lack of knowledge of recommended dosages and effectiveness. Given the prevalence and variation in prescribing, there is an urgent need to develop clear guidance for paediatricians managing children with sleep disturbance. (C) 2012 Elsevier B. V. All rights reserved.
C1 [Heussler, Helen; Chan, Patrick] Mater Childrens Hosp, Dept Resp & Sleep Med, Brisbane, Qld 4101, Australia.
   [Heussler, Helen] Mater Med Res Inst, Brisbane, Qld 4101, Australia.
   [Heussler, Helen] Univ Queensland, Sch Med, Herston, Qld 4006, Australia.
   [Price, Anna M. H.; Hiscock, Harriet] Royal Childrens Hosp, Ctr Community Child Hlth, Parkville, Vic 3052, Australia.
   [Price, Anna M. H.; Hiscock, Harriet] Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia.
   [Waters, Karen] Sydney Childrens Hosp Network, Resp Support Serv, Sydney, NSW 2000, Australia.
   [Waters, Karen] Univ Sydney, Sydney, NSW 2000, Australia.
   [Davey, Margot J.] Monash Med Ctr, Melbourne Childrens Sleep Ctr, Clayton, Vic 3168, Australia.
   [Hiscock, Harriet] Univ Melbourne, Dept Paediat, Carlton, Vic 3053, Australia.
RP Price, AMH (reprint author), Royal Childrens Hosp, Ctr Community Child Hlth, Flemington Rd, Parkville, Vic 3052, Australia.
EM anna.price@mcri.edu.au
RI Hiscock, Harriet/M-6882-2013
CR Australian Bureau of Statistics (ABS), 2006, CENS POP HOUS IND PA
   Braam W, 2009, DEV MED CHILD NEUROL, V51, P340, DOI 10.1111/j.1469-8749.2008.03244.x
   Buscemi N., 2004, EVID REP TECHNOL ASS, V108, P1
   Buscemi N, 2006, BRIT MED J, V332, P385, DOI 10.1136/bmj-38731.632766.F6
   Clark AF, 2004, J PSYCHOPHARMACOL, V18, P115, DOI 10.1177/0269881104040249
   Corkum P, 2011, PEDIATR CLIN N AM, V58, P667, DOI 10.1016/j.pcl.2011.03.004
   Heussler H, 2007, WORLD SLEEP C BRISB
   Hiscock H, 2011, MED J AUSTRALIA, V194, P392
   Hiscock H, 2010, J PAEDIATR CHILD H, V48, P6
   HUETHER G, 1994, ANN NY ACAD SCI, V719, P146, DOI 10.1111/j.1749-6632.1994.tb56826.x
   Iuvone PM, 2005, PROG RETIN EYE RES, V24, P433, DOI 10.1016/j.preteyeres.2005.01.003
   Khan S, 2011, COCHRANE DATABASE SY, V11
   Khanna P, 2009, RACP WORKFORCE SURVE
   LERNER AB, 1958, J AM CHEM SOC, V80, P2587, DOI 10.1021/ja01543a060
   LUBOSHITZKY R, 1995, J CLIN ENDOCR METAB, V80, P2144, DOI 10.1210/jc.80.7.2144
   Luboshitzky R, 2000, EXP CLIN ENDOCR DIAB, V108, P142, DOI 10.1055/s-2000-5809
   Martin J, 2007, PEDIATRICS, V119, P947, DOI 10.1542/peds.2006-2569
   Mindell JA, 2006, SLEEP, V29, P1263
   Nikles J, 2012, MED J AUSTRALIA, V196, P384, DOI 10.5694/mja12.10145
   Owens JA, 2002, CURR THER RES CLIN E, V63, pB38, DOI 10.1016/S0011-393X(02)80102-3
   Owens JA, 2010, SLEEP MED, V11, P692, DOI 10.1016/j.sleep.2009.11.015
   Owens JA, 2005, J DEV BEHAV PEDIATR, V26, P312, DOI 10.1097/00004703-200508000-00011
   Owens JA, 2009, CHILD ADOL PSYCH CL, V18, P1001, DOI 10.1016/j.chc.2009.04.009
   Owens JA, 2003, PEDIATRICS, V111, pE628, DOI 10.1542/peds.111.5.e628
   Quach J, 2009, PEDIATRICS, V123, P1287, DOI 10.1542/peds.2008-1860
   Quine L, 2001, CHILD CARE HLTH DEV, V27, P201, DOI 10.1046/j.1365-2214.2001.00213.x
   Reiter RJ, 2010, PROG BRAIN RES, V181, P127, DOI 10.1016/S0079-6123(08)81008-4
   Rossignol DA, 2011, DEV MED CHILD NEUROL, V53, P783, DOI 10.1111/j.1469-8749.2011.03980.x
   Rudolph S, 2009, J PAEDIATR CHILD H, V45, P704, DOI 10.1111/j.1440-1754.2009.01598.x
   Sadeh A, 2002, CHILD DEV, V73, P405, DOI 10.1111/1467-8624.00414
   Stein MA, 2001, PEDIATRICS, V107, DOI 10.1542/peds.107.4.e60
   Sung V, 2008, ARCH PEDIAT ADOL MED, V162, P336, DOI 10.1001/archpedi.162.4.336
   van Geijlswijk IM, 2011, PSYCHOPHARMACOLOGY, V216, P111, DOI 10.1007/s00213-011-2202-y
   van Geijlswijk IM, 2010, PSYCHOPHARMACOLOGY, V212, P379, DOI 10.1007/s00213-010-1962-0
   Vriend JL, 2011, J PEDIATR PSYCHOL, V36, P1017, DOI 10.1093/jpepsy/jsr044
   Waldron DL, 2005, ARCH DIS CHILD, V90, P1206, DOI 10.1136/adc.2005.077289
NR 36
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD FEB
PY 2013
VL 14
IS 2
BP 189
EP 194
DI 10.1016/j.sleep.2012.09.023
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 088XQ
UT WOS:000314871600013
PM 23245853
ER

PT J
AU Haworth, CMA
   Davis, OSP
   Plomin, R
AF Haworth, Claire M. A.
   Davis, Oliver S. P.
   Plomin, Robert
TI Twins Early Development Study (TEDS): A Genetically Sensitive
   Investigation of Cognitive and Behavioral Development From Childhood to
   Young Adulthood
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
DE Twins Early Development Study; twins; genetics; environment;
   longitudinal; behavioral genetics
ID GENOME-WIDE ASSOCIATION; ANXIETY-RELATED BEHAVIORS;
   ENVIRONMENTAL-INFLUENCES; LONGITUDINAL TWIN; MIDDLE CHILDHOOD;
   LANGUAGE-SKILLS; READING-DISABILITY; AUTISM SPECTRUM; ADHD SYMPTOMS; DNA
   MARKERS
AB The Twins Early Development Study (TEDS) is a large longitudinal sample of twins born in England and Wales between 1994 and 1996. The focus of TEDS has been on cognitive and behavioral development, including difficulties in the context of normal development. TEDS began when multiple births were identified from birth records and the families were invited to take part in the study; 16,810 pairs of twins were originally enrolled in TEDS. More than 10,000 of these twin pairs remain enrolled in the study to date. DNA has been collected for more than 7,000 pairs, and genome-wide genotyping data for two million DNA markers are available for 3,500 individuals. The TEDS families have taken part in studies when the twins were aged 2, 3, 4, 7, 8, 9, 10, 12, 14, and 16 years of age. Data collection is currently underway to assess the adult destinations of the twins as they move from school to university and the workplace. Between January 2012 and December 2014, all of the TEDS twins will turn 18, and the study will transition to an adult sample. TEDS represents an outstanding resource for investigating the developmental effects of genes and environments on complex quantitative traits from childhood to young adulthood and beyond.
C1 [Haworth, Claire M. A.; Davis, Oliver S. P.; Plomin, Robert] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat, London SE5 8AF, England.
RP Haworth, CMA (reprint author), Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat, P080,De Crespigny Pk, London SE5 8AF, England.
EM Claire.Haworth@kcl.ac.uk
RI Haworth, Claire/C-7073-2009; Davis, Oliver/B-9653-2008
OI Davis, Oliver/0000-0002-6448-3684
FU UK Medical Research Council [G9424799, G0500079, G0901245, G19/2]; US
   National Institutes of Health [HD044454, HD046167, HD059215]; NIH
   [HD049861]; Wellcome Trust [GR075492, WT084728]; Autism Speaks [4743];
   John Templeton Foundation [13575]; British Academy; Sir Henry Wellcome
   Fellowship [WT088984]; European Research Council Advanced Investigator
   Award [295366]
FX The authors are enormously grateful to the twins, parents, and the
   twins' teachers who have supported the Twins Early Development Study
   (TEDS) for the past 18 years. TEDS has also benefited from an
   exceptionally gifted group of researchers and support staff. The authors
   would especially like to thank the current TEDS team, including Rachel
   Ogden, Andrew McMillan, Kathryn Carter, Francesca Lewis, Neil Harvey,
   Rae Gardner-Kimball, and Louise Webster, for their enduring dedication
   to the project. TEDS has been continuously supported by the UK Medical
   Research Council since 1995 (G9424799, G0500079, and now G0901245). The
   authors' work on environments and academic achievement is also supported
   by grants from the US National Institutes of Health (HD044454, HD046167,
   and HD059215). The authors' molecular genetic research has been partly
   supported by grants from the NIH (HD049861), Wellcome Trust (GR075492,
   WT084728), Autism Speaks (4743), and John Templeton Foundation (13575).
   CMAH is supported by a research fellowship from the British Academy;
   OSPD is supported by a Sir Henry Wellcome Fellowship (WT088984); RP is
   supported by a research professorship from the UK Medical Research
   Council (G19/2) and a European Research Council Advanced Investigator
   Award (295366).
CR Arden R, 2006, PERS INDIV DIFFER, V41, P39, DOI 10.1016/j.paid.2005.11.027
   Asbury K, 2005, INTELLIGENCE, V33, P643, DOI 10.1016/j.intell.2005.03.008
   Asbury K, 2008, TWIN RES HUM GENET, V11, P586, DOI 10.1375/twin.11.6.586
   Butcher LM, 2008, GENES BRAIN BEHAV, V7, P435, DOI 10.1111/j.1601-183X.2007.00368.x
   Dale PS, 1998, NAT NEUROSCI, V1, P324
   Dale PS, 2010, J SPEECH LANG HEAR R, V53, P982, DOI 10.1044/1092-4388(2009/09-0108)
   Dale PS, 2010, PSYCHOL SCI, V21, P635, DOI 10.1177/0956797610368060
   Davis OSP, 2012, MOL PSYCHIATR, V17, P867, DOI 10.1038/mp.2012.68
   Davis OSP, 2009, PSYCHOL SCI, V20, P1301, DOI 10.1111/j.1467-9280.2009.02433.x
   Davis OSP, 2008, GENES BRAIN BEHAV, V7, P455, DOI 10.1111/j.1601-183X.2007.00370.x
   Davis OSP, 2010, BEHAV GENET, V40, P759, DOI 10.1007/s10519-010-9350-4
   Dionne G, 2003, CHILD DEV, V74, P394, DOI 10.1111/1467-8624.7402005
   Docherty SJ, 2010, GENES BRAIN BEHAV, V9, P234, DOI 10.1111/j.1601-183X.2009.00553.x
   Eley TC, 2003, J CHILD PSYCHOL PSYC, V44, P945, DOI 10.1111/1469-7610.00179
   Gregory AM, 2004, J AM ACAD CHILD PSY, V43, P744, DOI 10.1097/01.chi/0000122798.47863.a5
   Greven CU, 2012, J CHILD PSYCHOL PSYC, V53, P234, DOI 10.1111/j.1469-7610.2011.02445.x
   Greven CU, 2009, PSYCHOL SCI, V20, P753, DOI 10.1111/j.1467-9280.2009.02366.x
   Greven CU, 2011, J ABNORM CHILD PSYCH, V39, P623, DOI 10.1007/s10802-011-9513-7
   Hanscombe KB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030320
   Hanscombe KB, 2010, LEARN INDIVID DIFFER, V20, P549, DOI 10.1016/j.lindif.2010.06.005
   Harlaar N, 2007, CHILD DEV, V78, P116, DOI 10.1111/j.1467-8624.2007.00988.x
   Harlaar N, 2005, J CHILD PSYCHOL PSYC, V46, P1097, DOI 10.1111/j.1469-7610.2005.01515.x
   Haworth C. M. A., LEARNING IN IN PRESS
   Haworth CMA, 2008, OBESITY, V16, P2663, DOI 10.1038/oby.2008.434
   Haworth CMA, 2010, J AM ACAD CHILD PSY, V49, P783, DOI 10.1016/j.jaac.2010.01.026
   Haworth CMA, 2009, J CHILD PSYCHOL PSYC, V50, P1318, DOI 10.1111/j.1469-7610.2009.02114.x
   Haworth CMA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016006
   Haworth CMA, 2009, CHILD DEV, V80, P662, DOI 10.1111/j.1467-8624.2009.01289.x
   Haworth CMA, 2007, TWIN RES HUM GENET, V10, P554, DOI 10.1375/twin.10.4.554
   Hayiou-Thomas ME, 2006, J CHILD LANG, V33, P339, DOI 10.1017/S0305000906007331
   Hayiou-Thomas ME, 2012, DEVELOPMENTAL SCI, V15, P233, DOI 10.1111/j.1467-7687.2011.01119.x
   Iervolino AC, 2005, CHILD DEV, V76, P826, DOI 10.1111/j.1467-8624.2005.00880.x
   Knafo A, 2006, DEV PSYCHOL, V42, P771, DOI 10.1073/0012-1649.42.5.771
   Koeppen-Schomerus G, 2000, J PEDIATR-US, V137, P527, DOI 10.1067/mpd.2000.108445
   Kovas Yulia, 2007, Monogr Soc Res Child Dev, V72, P1
   Kovas Y, 2007, J CHILD PSYCHOL PSYC, V48, P914, DOI 10.1111/j.1469-7610.2007.01748.x
   Larsson H, 2008, J ABNORM CHILD PSYCH, V36, P633, DOI 10.1007/s10802-007-9151-2
   Loat CS, 2008, ANN HUM GENET, V72, P742, DOI 10.1111/j.1469-1809.2008.00470.x
   Meaburn EL, 2008, MOL PSYCHIATR, V13, P729, DOI 10.1038/sj.mp.4002063
   Oliver B, 2004, J CHILD LANG, V31, P609, DOI 10.1017/S030S000904006221
   Oliver B, 2002, EARLY CHILD DEV CARE, V172, P337, DOI 10.1080/03004430212713
   Oliver BR, 2008, J CHILD PSYCHOL PSYC, V49, P646, DOI 10.1111/j.1469-7610.2008.01891.x
   Oliver BR, 2007, TWIN RES HUM GENET, V10, P96, DOI 10.1375/twin.10.1.96
   Petrill SA, 2002, INTELLIGENCE, V30, P353, DOI 10.1016/S0160-2896(02)00087-9
   Petrill SA, 2001, INTELLIGENCE, V29, P31, DOI 10.1016/S0160-2896(00)00041-6
   Plomin R, PSYCHOL SCI IN PRESS
   Plomin R, 2001, BEHAV GENET, V31, P497, DOI 10.1023/A:1013385125887
   Plomin R, 2013, CHILD DEV, V84, P104, DOI 10.1111/j.1467-8624.2012.01757.x
   Price T S, 2000, Twin Res, V3, P129, DOI 10.1375/136905200320565391
   Price TS, 2010, CHILD DEV, V81, P101, DOI 10.1111/j.1467-8624.2009.01383.x
   Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
   Ronald A, 2010, CHILD DEV, V81, P166, DOI 10.1111/j.1467-8624.2009.01387.x
   Ronald A, 2010, BEHAV GENET, V40, P31, DOI 10.1007/s10519-009-9308-6
   Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
   Saudino KJ, 1998, BRIT J DEV PSYCHOL, V16, P349
   Saudino KJ, 2005, J ABNORM CHILD PSYCH, V33, P113, DOI 10.1007/s10802-005-0939-7
   Spinath FM, 2004, CHILD DEV, V75, P445, DOI 10.1111/j.1467-8624.2004.00685.x
   Trouton A, 2002, TWIN RES, V5, P444, DOI 10.1375/136905202320906255
   Trzaskowski M, 2012, J ABNORM CHILD PSYCH, V40, P85, DOI 10.1007/s10802-011-9545-z
   Viding E, 2004, J CHILD PSYCHOL PSYC, V45, P315, DOI 10.1111/j.1469-7610.2004.00223.x
   Viding E, 2005, J CHILD PSYCHOL PSYC, V46, P592, DOI 10.1111/j.1469-7610.2004.00393.x
   Viding E, 2010, J CHILD PSYCHOL PSYC, V51, P780, DOI 10.1111/j.1469-7610.2010.02236.x
   Walker A., 2001, LIVING BRITAIN RESUL
   Walker SO, 2004, BRIT J EDUC PSYCHOL, V74, P323, DOI 10.1348/0007099041552387
   Wardle J, 2008, AM J CLIN NUTR, V87, P398
NR 65
TC 33
Z9 33
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD FEB
PY 2013
VL 16
IS 1
BP 117
EP 125
DI 10.1017/thg.2012.91
PG 9
WC Genetics & Heredity; Obstetrics & Gynecology
SC Genetics & Heredity; Obstetrics & Gynecology
GA 087YD
UT WOS:000314799700017
PM 23110994
ER

PT J
AU Magnusson, PKE
   Almqvist, C
   Rahman, I
   Ganna, A
   Viktorin, A
   Walum, H
   Halldner, L
   Lundstrom, S
   Ullen, F
   Langstrom, N
   Larsson, H
   Nyman, A
   Gumpert, CH
   Rastam, M
   Anckarsater, H
   Cnattingius, S
   Johannesson, M
   Ingelsson, E
   Klareskog, L
   de Faire, U
   Pedersen, NL
   Lichtenstein, P
AF Magnusson, Patrik K. E.
   Almqvist, Catarina
   Rahman, Iffat
   Ganna, Andrea
   Viktorin, Alexander
   Walum, Hasse
   Halldner, Linda
   Lundstrom, Sebastian
   Ullen, Fredrik
   Langstrom, Niklas
   Larsson, Henrik
   Nyman, Anastasia
   Gumpert, Clara Hellner
   Rastam, Maria
   Anckarsater, Henrik
   Cnattingius, Sven
   Johannesson, Magnus
   Ingelsson, Erik
   Klareskog, Lars
   de Faire, Ulf
   Pedersen, Nancy L.
   Lichtenstein, Paul
TI The Swedish Twin Registry: Establishment of a Biobank and Other Recent
   Developments
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
DE population-based; twin; registry; biobank; Sweden
ID BIRTH-WEIGHT; TELEPHONE INTERVIEW; AUTISM-TICS; A-TAC; ASSOCIATION;
   3RD-MILLENNIUM; VALIDITY; UNIQUE; CHILD; RISK
AB The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.
C1 [Magnusson, Patrik K. E.; Almqvist, Catarina; Rahman, Iffat; Ganna, Andrea; Viktorin, Alexander; Walum, Hasse; Halldner, Linda; Langstrom, Niklas; Larsson, Henrik; Nyman, Anastasia; Ingelsson, Erik; Pedersen, Nancy L.; Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden.
   [Almqvist, Catarina] Dept Womens & Childrens Hlth, Stockholm, Sweden.
   [Almqvist, Catarina] Astrid Lindgren Childrens Hosp, Stockholm, Sweden.
   [Halldner, Linda] Karolinska Inst, Ctr Neurodev Disorders KIND, Stockholm, Sweden.
   [Lundstrom, Sebastian; Anckarsater, Henrik] Univ Gothenburg, CELAM Ctr Eth Law & Mental Hlth, Gothenburg, Sweden.
   [Lundstrom, Sebastian; Langstrom, Niklas] Swedish Prison & Probat Serv, R&D Unit, Norrkoping, Sweden.
   [Lundstrom, Sebastian] Univ Gothenburg, Gillberg Neuropsychiat Ctr, Inst Neurosci & Physiol, Gothenburg, Sweden.
   [Ullen, Fredrik] Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
   [Gumpert, Clara Hellner] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res & Educ, Stockholm, Sweden.
   [Rastam, Maria] Lund Univ, Dept Clin Sci, Lund, Sweden.
   [Cnattingius, Sven] Karolinska Inst, Dept Med, Unit Clin Epidemiol, Stockholm, Sweden.
   [Johannesson, Magnus] Stockholm Sch Econ, Dept Econ, S-11383 Stockholm, Sweden.
   [Klareskog, Lars] Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden.
   [de Faire, Ulf] Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, S-10401 Stockholm, Sweden.
RP Magnusson, PKE (reprint author), Karolinska Inst, Dept Med Epidemiol & Biostat, Box 281, S-17177 Stockholm, Sweden.
EM patrik.magnusson@ki.se
RI Johannesson, Magnus/E-9680-2011
OI Johannesson, Magnus/0000-0001-8759-6393
FU Ministry for Higher Education; TwinGene; Swedish Research Council
   [M-2005-1112, 20113060, K2006-71X-14676-04-2, 2008-54x20638-01-3];
   GenomEUtwin [EU/QLRT-2001-01254, QLG2-CT-2002-01254]; NIH [DK
   U01-066134]; Swedish Foundation for Strategic Research (SSF); Heart and
   Lung foundation [20070481. STOPPA]; Strategic Research Program in
   Epidemiology at Karolinska Institutet; Swedish Asthma and Allergy
   Association; Stockholm County Council; Karolinska Institutet; Swedish
   Council for Working Life and Social Research; Swedish Research Council;
   Systembolaget; National Board of Forensic Medicine; Swedish Prison and
   Probation Service; Bank of Sweden Tercentenary Foundation;
   Soderstrom-Konigska foundation; Karolinska Institutet Center of
   Neurodevelopmental Disorders (KIND).; Swedish Council for Working Life
   and Social Research [2004-0174, 2007-0231]; Swedish Cancer Society
   [4594-B01-01XAC, 4594-B04-04XAB]; European Union [FP6 036894]
FX The Ministry for Higher Education financially supports the STR. For the
   various projects described here financial support has been provided by:
   TwinGene; the Swedish Research Council (M-2005-1112), GenomEUtwin
   (EU/QLRT-2001-01254; QLG2-CT-2002-01254), NIH DK U01-066134, The Swedish
   Foundation for Strategic Research (SSF), the Heart and Lung foundation
   no. 20070481. STOPPA; the Strategic Research Program in Epidemiology at
   Karolinska Institutet, the Swedish Research Council (grant number
   20113060), the Swedish Asthma and Allergy Association and the regional
   agreement on medical training and clinical research (ALF) between
   Stockholm County Council and Karolinska Institutet. CATSS; support was
   provided by the Swedish Council for Working Life and Social Research,
   the Swedish Research Council, Systembolaget, the National Board of
   Forensic Medicine, the Swedish Prison and Probation Service, Bank of
   Sweden Tercentenary Foundation, the Soderstrom-Konigska foundation, and
   the Karolinska Institutet Center of Neurodevelopmental Disorders (KIND).
   BIRTH; supported by the Swedish Council for Working Life and Social
   Research (2004-0174 and 2007-0231), the Swedish Research Council
   (K2006-71X-14676-04-2 and 2008-54x20638-01-3), the Swedish Cancer
   Society (4594-B01-01XAC and 4594-B04-04XAB), and the European
   Union-funded Network of Excellence Lifespan (FP6 036894).
CR Altman D, 2011, EUR UROL, V59, P280, DOI 10.1016/j.eururo.2010.10.028
   Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
   Benjamin DJ, 2012, P NATL ACAD SCI USA, V109, P8026, DOI 10.1073/pnas.1120666109
   Bergvall N, 2007, CIRCULATION, V115, P2931, DOI 10.1161/CIRCULATIONAHA.107.674812
   Cederlof R., 1966, THESIS KAROLINSKA I
   Cesarini D, 2012, MANAGE SCI, V58, P21, DOI 10.1287/mnsc.1110.1329
   EuroQol Group, 1990, HLTH POLICY, V16, P199, DOI DOI 10.1016/0168-8510(90)90421-9
   Formann A. K., 1979, WMT WIENER MATRIZENT
   Furberg H, 2008, NICOTINE TOB RES, V10, P1727, DOI 10.1080/14622200802443551
   Gold CH, 2002, J GERONTOL B-PSYCHOL, V57, pS168
   Hannelius U, 2007, TWIN RES HUM GENET, V10, P604, DOI 10.1375/twin.10.4.604
   Hansson SL, 2005, BRIT J PSYCHIAT, V187, P262, DOI 10.1192/bjp.187.3.262
   Harris CR, 2003, PSYCHOL WOMEN QUART, V27, P319, DOI 10.1111/1471-6402.00112
   Heath AC, 2003, TWIN RES, V6, P22, DOI 10.1375/136905203762687861
   Hedelin M., 2010, BMC PSYCHIATRY, V10, P1
   Hoekstra C, 2010, FERTIL STERIL, V93, P885, DOI 10.1016/j.fertnstert.2008.10.012
   Hoekstra C, 2008, HUM REPROD UPDATE, V14, P37, DOI 10.1093/humupd/dmm036
   Holm L, 2011, EXP BRAIN RES, V214, P175, DOI 10.1007/s00221-011-2817-6
   Humphreys K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022547
   Karlstrom PO, 2007, HUM REPROD, V22, P2202, DOI 10.1093/humrep/dem120
   Larson T, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-1
   Lichtenstein P, 2007, TWIN RES HUM GENET, V10, P67, DOI 10.1375/twin.10.1.67
   Lichtenstein P, 2006, TWIN RES HUM GENET, V9, P875, DOI 10.1375/183242706779462444
   Lichtenstein P, 2002, J INTERN MED, V252, P184, DOI 10.1046/j.1365-2796.2002.01032.x
   Lundholm C, 2010, CLIN EXP ALLERGY, V40, P1044, DOI 10.1111/j.1365-2222.2010.03519.x
   Medlund P, 1976, Acta Med Scand Suppl, V600, P1
   Meltzer-Brody S, 2011, J WOMENS HEALTH, V20, P863, DOI 10.1089/jwh.2010.2360
   Mosing MA, 2012, PERS INDIV DIFFER, V53, P699, DOI 10.1016/j.paid.2012.05.035
   Muthen L. K., 2006, MPLUS USERS GUIDE
   Nyman T, 2009, OCCUP ENVIRON MED, V66, P395, DOI 10.1136/oem.2008.042168
   Oberg S, 2011, CIRCULATION, V123, P2792, DOI 10.1161/CIRCULATIONAHA.110.987339
   Ortqvist AK, 2009, PEDIATRICS, V124, pE737, DOI 10.1542/peds.2009-0305
   Pedersen NL, 2002, TWIN RES, V5, P427, DOI 10.1375/136905202320906219
   Price AL, 2010, NAT REV GENET, V11, P459, DOI 10.1038/nrg2813
   Rahman I, 2009, TWIN RES HUM GENET, V12, P286, DOI 10.1375/twin.12.3.286
   Ripke S, 2011, NAT GENET, V43, P969, DOI 10.1038/ng.940
   Schuz J, 2011, CANCER EPIDEMIOL, V35, P37, DOI 10.1016/j.canep.2010.08.001
   SIMPSON JA, 1991, J PERS SOC PSYCHOL, V60, P870, DOI 10.1037/0022-3514.60.6.870
   Statistics Sweden, 2011, MULT REG 2010 DESCR
   Ullen F, 2012, PERS INDIV DIFFER, V52, P167, DOI 10.1016/j.paid.2011.10.003
   van Dongen J, 2012, NAT REV GENET, V13, P640, DOI 10.1038/nrg3243
   Walum H, 2008, P NATL ACAD SCI USA, V105, P14153, DOI 10.1073/pnas.0803081105
NR 42
TC 25
Z9 26
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD FEB
PY 2013
VL 16
IS 1
BP 317
EP 329
DI 10.1017/thg.2012.104
PG 13
WC Genetics & Heredity; Obstetrics & Gynecology
SC Genetics & Heredity; Obstetrics & Gynecology
GA 087YD
UT WOS:000314799700048
PM 23137839
ER

PT J
AU Schmidt, NL
   Van Hulle, CA
   Brooker, RJ
   Meyer, LR
   Lemery-Chalfant, K
   Goldsmith, HH
AF Schmidt, Nicole L.
   Van Hulle, Carol A.
   Brooker, Rebecca J.
   Meyer, Lauren R.
   Lemery-Chalfant, Kathryn
   Goldsmith, H. Hill
TI Wisconsin Twin Research: Early Development, Childhood Psychopathology,
   Autism, and Sensory Over-responsivity
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
DE twins; longitudinal; emotions; temperament; child psychopathology;
   autism; sensory
ID BRAIN ELECTRICAL-ACTIVITY; ENVIRONMENTAL-INFLUENCES; MIDDLE CHILDHOOD;
   CHILDREN
AB The Wisconsin Twin Research Program comprises multiple longitudinal studies that utilize a panel recruited from statewide birth records for the years 1989 through 2004. Our research foci are the etiology and developmental course of early emotions, temperament, childhood anxiety and impulsivity, autism, sensory over-responsivity, and related topics. A signature feature of this research program is the breadth and depth of assessment during key periods of development. The assessments include extensive home- and laboratory-based behavioral batteries, recorded sibling and caregiver interactions, structured psychiatric interviews with caregivers and adolescents, observer ratings of child behavior, child self-report, cognitive testing, neuroendocrine measures, medical records, dermatoglyphics, genotyping, and neuroimaging. Across the various studies, testing occasions occurred between 3 months and 18 years of age. Data collection for some aspects of the research program has concluded and, for other aspects, longitudinal follow-ups are in progress.
C1 [Schmidt, Nicole L.; Van Hulle, Carol A.; Brooker, Rebecca J.; Meyer, Lauren R.; Goldsmith, H. Hill] UW Madison, Madison, WI 53706 USA.
   [Lemery-Chalfant, Kathryn] Arizona State Univ, Phoenix, AZ USA.
RP Goldsmith, HH (reprint author), UW Madison, 328 Psychol Bldg,1202 Johnson St, Madison, WI 53706 USA.
EM hhgoldsm@wisc.edu
FU National Institute of Mental Health [R01-MH059785, R01-MH069793,
   R37-MH050560]; Wisconsin Center for Affective Science [P50-MH069315];
   Conte Neuroscience Center [P50-MH084051]; Wallace Research Foundation;
   National Alliance for Autism Research; Eunice Kennedy Shriver National
   Institute of Child Health and Human Development [P30 HD003352]
FX This work was supported by the National Institute of Mental Health
   (R01-MH059785, R01-MH069793, R37-MH050560), the Wisconsin Center for
   Affective Science (P50-MH069315), a Conte Neuroscience Center
   (P50-MH084051), the Wallace Research Foundation, and the National
   Alliance for Autism Research. Infrastructure support was provided by the
   Waisman Center via a core grant from the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (P30 HD003352). The
   authors owe special gratitude to Wisconsin twins and their families for
   their research participation.
CR Armstrong J. M., 2003, MANUAL MACARTHUR HLT
   Brooker R., 2012, DEV STRANGER FEAR IN
   Constantino JN, 2002, SOCIAL RESPONSIVENES
   Dunn W., 1999, SENSORY PROFILE MANU
   Goldsmith H. H., 2012, INT M AUT RES TOR CA
   Goldsmith HH, 2007, TWIN RES HUM GENET, V10, P118, DOI 10.1375/twin.10.1.118
   Keuler MM, 2011, J DEV BEHAV PEDIATR, V32, P533, DOI 10.1097/DBP.0b013e3182245c05
   Lemery-Chalfant K, 2006, TWIN RES HUM GENET, V9, P1030, DOI 10.1375/183242706779462363
   Light SN, 2009, DEV PSYCHOL, V45, P525, DOI 10.1037/a0014576
   Light SN, 2009, CHILD DEV, V80, P1210, DOI 10.1111/j.1467-8624.2009.01326.x
   Locke R. L., 2007, BIENN M SOC RES CHIL
   Lord C., 2001, AUTISM DIAGNOSTIC OB
   Rutter M., 2003, SOCIAL COMMUNICATION
   Schreiber JE, 2006, PSYCHONEUROENDOCRINO, V31, P1131, DOI 10.1016/j.psyneuen.2006.07.005
   SchwabStone ME, 1996, J AM ACAD CHILD PSY, V35, P878, DOI 10.1097/00004583-199607000-00013
   U.S. Bureau of the Census, 2000, CENS 2000 SUMM FIL 3
   Van Hulle C., 2011, J CHILD PSYCHOL PSYC, V53, P64
   Van Hulle CA, 2012, HORM BEHAV, V62, P36, DOI 10.1016/j.yhbeh.2012.04.014
   Wagner AI, 2009, J DEV BEHAV PEDIATR, V30, P217, DOI 10.1097/DBP.0b013e3181a7ee98
NR 19
TC 3
Z9 3
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD FEB
PY 2013
VL 16
IS 1
BP 376
EP 384
DI 10.1017/thg.2012.105
PG 9
WC Genetics & Heredity; Obstetrics & Gynecology
SC Genetics & Heredity; Obstetrics & Gynecology
GA 087YD
UT WOS:000314799700057
PM 23200241
ER

PT J
AU Farmer, J
   Reupert, A
AF Farmer, Judy
   Reupert, Andrea
TI Understanding Autism and understanding my child with Autism: An
   evaluation of a group parent education program in rural Australia
SO AUSTRALIAN JOURNAL OF RURAL HEALTH
LA English
DT Article
DE Autism; multi-stranded content; parent education; parent group; rural
ID RANDOMIZED CONTROLLED-TRIAL; SPECTRUM DISORDERS; PRESCHOOL-CHILDREN;
   ASPERGER-SYNDROME; STRESS; INTERVENTIONS
AB Objective To describe and evaluate a six-session program provided to parents of children with Autism in rural Australia. The program was designed to improve parent's knowledge and understanding of Autism, improve their confidence in managing their child and decrease parental anxiety. Design A self-constructed questionnaire administered pre- and post-intervention. Setting An early intervention centre in a large town in rural Victoria. Participants Ninety-eight parents (or family members) of young children primarily aged 26 years of age, diagnosed with Autism. Interventions A multi-stranded content' program was offered over six evenings. Ten programs were conducted over six years. Results The pre- versus post-session analysis using a paired t-test on matched person-to-person parental responses (n=92) showed significant increases in parental understanding of Autism and understanding of their own child (P<0.001), and in understanding the communication, sensory, social, learning and behavioural features of Autism (P<0.001). Significant increases in parental confidence and a significant reduction in parental anxiety were also shown (P<0.001). Qualitative data indicated that parents valued learning about the general nature of Autism and sensory processing, and reported feeling less alone. Conclusions The six-week program was successful in terms of its aims. Parent feedback indicated that ongoing parent education sessions at regular intervals would enhance the impact of the program.
C1 [Reupert, Andrea] Monash Univ, Fac Educ, Clayton, Vic 3168, Australia.
RP Farmer, J (reprint author), 101 Lardner Rd, Drouin, Vic 3818, Australia.
EM thegables@dcsi.net.au
FU Australian Government Department of Health and Ageing under the PHCRED
   strategy through Monash University Gippsland
FX The writing of this paper was supported in part by the Australian
   Government Department of Health and Ageing under the PHCRED strategy
   through Monash University Gippsland.
CR Autism Victoria, 2009, PROF ADV PAN POS STA
   Baker-Ericzen MJ, 2005, RES PRACT PERS SEV D, V30, P194, DOI 10.2511/rpsd.30.4.194
   Bogdashina O, 2003, SENSORY PERCEPTUAL I
   Brookman-Frazee L, 2006, CLIN CHILD FAM PSYCH, V9, P181, DOI 10.1007/s10567-006-0010-4
   Dodd S, 2005, UNDERSTANDING AUTISM
   Emerging Themes National Inquiry into Rural & Remote Education, 2000, COMM AUSTR
   Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
   Gabriels RL, 2002, AUTISM RES INDIVIDUA
   Hayes N., 2000, DOING PSYCHOL RES GA
   Howlin P, 1998, CHILDREN AUTISM ASPE
   Humphreys John, 2002, Aust J Rural Health, V10, P2, DOI 10.1046/j.1440-1584.2002.00435.x
   Kilham C, 2010, CURRICULUM TECHNOLOG, P511
   Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
   Peterson C, 2008, TASA C P MELB 2008
   Principles of Recruitment and Retention of Allied Health Professionals Serving Remote Australian Communities, 2010, POS PAP
   Roberts J, 2007, BUILDING BLOCKS EARL
   Shields J, 2001, AUTISM, V5, P49, DOI 10.1177/1362361301005001005
   Sofronoff K, 2004, AUTISM, V8, P301, DOI 10.1177/136261304045215
   Sofronoff K, 2002, AUTISM, V6, P271, DOI 10.1177/1362361302006003005
   Strasser R P, 2000, Aust J Rural Health, V8, P222, DOI 10.1046/j.1440-1584.2000.00305.x
   Tonge B, 2006, J AM ACAD CHILD PSY, V45, P561, DOI 10.1097/01.chi.0000205701.48324.26
   Whitaker P, 2002, AUTISM, V6, P411, DOI 10.1177/1362361302006004007
   Whittingham K, 2009, J ABNORM CHILD PSYCH, V37, P469, DOI 10.1007/s10802-008-9285-x
NR 23
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1038-5282
J9 AUST J RURAL HEALTH
JI Aust. J. Rural Health
PD FEB
PY 2013
VL 21
IS 1
BP 20
EP 27
DI 10.1111/ajr.12004
PG 8
WC Public, Environmental & Occupational Health; Nursing
SC Public, Environmental & Occupational Health; Nursing
GA 085DM
UT WOS:000314593200005
PM 23384133
ER

PT J
AU Kaga, M
AF Kaga, Makiko
TI Exploring autism research collaboration between Japan and United States
   Joint Academic Conference on Autism Spectrum Disorders, December, 2011
   Preface
SO BRAIN & DEVELOPMENT
LA English
DT Editorial Material
C1 Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Kodaira, Tokyo 1878553, Japan.
RP Kaga, M (reprint author), Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878553, Japan.
EM kaga@ncnp.go.jp
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 95
EP 95
DI 10.1016/j.braindev.2012.09.005
PG 1
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400001
PM 23107149
ER

PT J
AU Senju, A
AF Senju, Atsushi
TI Atypical development of spontaneous social cognition in autism spectrum
   disorders
SO BRAIN & DEVELOPMENT
LA English
DT Review
DE Autism spectrum disorders; Theory of Mind; Imitation; Mimicry; Eye gaze;
   Gaze processing; Social cognition
ID MIRROR-NEURON SYSTEM; EYE-GAZE; ASPERGER-SYNDROME; DEVELOPING-CHILDREN;
   MIND; INDIVIDUALS; ATTRIBUTION; IMITATION; DIRECTION; RECOGNITION
AB Individuals with autism spectrum disorders (ASD) have profound impairment in the development of social interaction and communication. However, it is also known that some 'high-functioning' individuals with ASD show apparently typical capacity to. process social information in a controlled experimental settings, despite their difficulties in daily life. The current paper overviews the spontaneous social cognition, spontaneous processing of social information in the absence of explicit instruction or task demand, in individuals with ASD. Three areas of the researches, false belief attribution, imitation/mimicry, and eye gaze processing, have been reviewed. The literatures suggest that high-functioning individuals with ASD (a) do not spontaneously attribute false belief to others, even though they can easily do so when explicitly instructed, (b) can imitate others' goal-directed actions under explicit instruction and show spontaneous mimicry of others' actions when they attend to the action, but are less likely to show spontaneous mimicry without the task structure to navigate attention to others' action and (c) can process others' gaze direction and shift attention to others' gaze directions, but fail to spontaneously attend to another person's eyes in social and communicative context, and less likely to:be prompted to respond in response to perceived eye contact. These results are consistent with the claim that individuals with ASD do not spontaneously attend to socially relevant information, even though they can easily process the same information when their attention is navigated towards it. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 Univ London, Ctr Brain & Cognit Dev, London WC1E 7HX, England.
RP Senju, A (reprint author), Univ London, Ctr Brain & Cognit Dev, Malet St, London WC1E 7HX, England.
EM a.senju@bbk.ac.uk
FU UK Medical Research Council [G1100252]
FX The contents of this paper are based on the presentation at the
   "Exploring Autism Research Collaboration between Japan and United States
   Joint Academic Conference on Autism Spectrum Disorders", Tokyo, Japan,
   December 1-3, 2011. The author was supported by the UK Medical Research
   Council Career Development Award (G1100252) during the preparation of
   this paper.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baillargeon R, 2010, TRENDS COGN SCI, V14, P110, DOI 10.1016/j.tics.2009.12.006
   BARONCOHEN S, 1995, BRIT J DEV PSYCHOL, V13, P379
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Birch SAJ, 2003, PSYCHOL SCI, V14, P283, DOI 10.1111/1467-9280.03436
   Bird G, 2007, P ROY SOC B-BIOL SCI, V274, P3027, DOI 10.1098/rspb.2007.1019
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Frischen A, 2007, PSYCHOL BULL, V133, P694, DOI 10.1037/0033-2909.133.4.694
   Giganti F, 2009, CURR PSYCHOL LETT, V25, P1
   Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025
   Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
   Helt MS, 2010, CHILD DEV, V81, P1620, DOI 10.1111/j.1467-8624.2010.01495.x
   Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
   Kikuchi Y, 2011, J AUTISM DEV DISORD, V41, P629, DOI 10.1007/s10803-010-1082-z
   Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
   Leekam S, 1997, BRIT J DEV PSYCHOL, V15, P77
   Magnee MJCM, 2007, J CHILD PSYCHOL PSYC, V48, P1122, DOI 10.1111/j.1469-7610.2007.01779.x
   McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
   Nation K, 2008, DEV PSYCHOPATHOL, V20, P79, DOI 10.1017/S0954579408000047
   OZONOFF S, 1995, J AUTISM DEV DISORD, V25, P415, DOI 10.1007/BF02179376
   Pellicano E, 2009, PSYCHON B REV, V16, P1094, DOI 10.3758/PBR.16.6.1094
   Press C, 2010, NEUROPSYCHOLOGIA, V48, P3291, DOI 10.1016/j.neuropsychologia.2010.07.012
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001
   Senju A, 2004, J CHILD PSYCHOL PSYC, V45, P445, DOI 10.1111/j.1469-7610.2004.00236.x
   Senju A, 2009, J AUTISM DEV DISORD, V39, P1598, DOI 10.1007/s10803-009-0785-5
   Senju A, 2005, VIS COGN, V12, P1474, DOI 10.1080/13506280444000797
   Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009
   Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
   Senju A, 2007, BIOLOGY LETT, V3, P706, DOI 10.1098/rsbl.2007.0337
   SMITH IM, 1994, PSYCHOL BULL, V116, P259, DOI 10.1037/0033-2909.116.2.259
   Southgate V, 2007, PSYCHOL SCI, V18, P587, DOI 10.1111/j.1467-9280.2007.01944.x
   Southgate V, 2008, TRENDS COGN SCI, V12, P225, DOI 10.1016/j.tics.2008.03.005
   Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925
   vonGrunau M, 1995, PERCEPTION, V24, P1297
   Wallace S, 2006, PERCEPTION, V35, P1651, DOI 10.1068/p5442
NR 42
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 96
EP 101
DI 10.1016/j.braindev.2012.08.002
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400002
PM 22964276
ER

PT J
AU Honda, H
AF Honda, Hideo
TI How can epidemiological studies contribute to understanding autism
   spectrum disorders?
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE Autism spectrum disorders; Prevalence; Incidence; Accuracy; Precision
ID TOTAL POPULATION; CUMULATIVE INCIDENCE; CHILDHOOD AUTISM; CHILDREN;
   JAPAN
AB More and more studies on the frequency of autism spectrum disorders (ASD) have been published recently, most of which show the increase in prevalence data. In this review, the author pointed out factors and parameters to be considered in analyzing frequency data, i.e., the enlargement of the concept of autism, prevalence and incidence, accuracy and precision in the initial screening, and the effect of the "vaccine debate". The proportion of high-functioning ASD has been growing higher and higher due to better recognition in the last few years, and the apparent increase might still be the tip of an iceberg. Future epidemiological studies should include themes on diversity of the longitudinal course and re-conceptualization of ASD by dimensional diagnosis. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 Yamanashi Prefectural Ctr Psychol Dev, Kofu, Yamanashi 4000005, Japan.
RP Honda, H (reprint author), Yamanashi Prefectural Ctr Psychol Dev, 1-2-12 Kitashin, Kofu, Yamanashi 4000005, Japan.
EM honda-amgz@pref.yamanashi.lg.jp
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   American Psychiatric Association, 1980, DIAGN STAT MAN MENT
   EHLERS S, 1993, J CHILD PSYCHOL PSYC, V34, P1327, DOI 10.1111/j.1469-7610.1993.tb02094.x
   Honda H, 2005, DEV MED CHILD NEUROL, V47, P10, DOI 10.1017/S0012162205000034
   Honda H, 2002, AUTISM, V6, P239, DOI 10.1177/1362361302006003003
   Honda H, 2005, J CHILD PSYCHOL PSYC, V46, P572, DOI 10.1111/j.1469-7610.2005.01425.x
   Honda H, 2009, J CHILD PSYCHOL PSYC, V50, P972, DOI 10.1111/j.1469-7610.2009.02055.x
   Honda H, 1996, BRIT J PSYCHIAT, V169, P228, DOI 10.1192/bjp.169.2.228
   Kanner L, 1944, J PEDIATR-US, V25, P211, DOI 10.1016/S0022-3476(44)80156-1
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Lotter V., 1966, SOC PSYCHIAT, P124, DOI DOI 10.1007/BF00584048
   Madsen KM, 2003, PEDIATRICS, V112, P604, DOI 10.1542/peds.112.3.604
   Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
   Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
NR 15
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 102
EP 105
DI 10.1016/j.braindev.2012.06.003
PG 4
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400003
PM 22766241
ER

PT J
AU Uchino, S
   Waga, C
AF Uchino, Shigeo
   Waga, Chikako
TI SHANK3 as an autism spectrum disorder-associated gene
SO BRAIN & DEVELOPMENT
LA English
DT Review
DE Autism spectrum disorder; SHANK3; 22q13.3 Deletion syndrome; DNA
   methylation; Synapse
ID 22Q13.3 DELETION SYNDROME; SCAFFOLDING PROTEIN SHANK3; COPY NUMBER
   VARIATION; DIFFERENTIAL EXPRESSION; DNA METHYLATION; FAMILY; MUTATIONS;
   IDENTIFICATION; DYSFUNCTION; BEHAVIORS
AB SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density of excitatory synapses, and plays important roles in the formation, maturation, and maintenance of synapses. Haploinsufficiency of the SHANK3 gene causes a developmental disorder, 22q13.3 deletion syndrome (known as Phelan-McDermid syndrome), that is characterized by severe expressive language and speech delay, hypotonia, global developmental delay, and autistic behavior. Since several SHANK3 mutations have been identified in a particular phenotypic group in patients with autism spectrum disorder (ASD), the SHANK3 is strongly suspected of being involved in the pathogenesis and neuropathology of ASD. Five CpG-islands have been identified in the SHANK3 gene, and tissue-specific expression of SHANK3 is regulated by DNA methylation in an epigenetic manner. Cumulative evidence has shown that several SHANK3 variants are expressed in the developing rodent brain and that their expression is regulated by DNA methylation of intragenic promoters. We identified novel SHANK3 transcripts whose transcription started at the vicinity of the CpG-island 2 in the mouse brain. Shank3 mutant mice exhibit autistic-like behaviors, including impaired social interaction and repetitive behaviors. In this article we review recent findings in regard to higher brain functions of SHANK3, epigenetic regulation of SHANK3 expression, and SHANK3-related ASD that were obtained from genetic analyses in ASD patients, molecular biological studies using developing mouse brains, and studies of Shank3 mutant mice. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 [Uchino, Shigeo; Waga, Chikako] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Neurochem, Kodaira, Tokyo 1878502, Japan.
RP Uchino, S (reprint author), Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Neurochem, 4-1-1 Ogawahigashi, Kodaira, Tokyo 1878502, Japan.
EM uchino@ncnp.go.jp
CR Awadalla P, 2010, AM J HUM GENET, V87, P316, DOI 10.1016/j.ajhg.2010.07.019
   Bangash MA, 2011, CELL, V145, P758, DOI 10.1016/j.cell.2011.03.052
   Beri S, 2007, J NEUROCHEM, V101, P1380, DOI 10.1111/j.1471-4159.2007.04539.x
   Bockers TM, 2004, MOL CELL NEUROSCI, V26, P182, DOI 10.1016/j.mcn.2004.01.009
   Bonaglia MC, 2006, J MED GENET, V43, P822, DOI 10.1136/jmg.2005.038604
   Bonaglia MC, 2001, AM J HUM GENET, V69, P261, DOI 10.1086/321293
   Bozdagi O, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-15
   Ching TT, 2005, NAT GENET, V37, P645, DOI 10.1038/ng1563
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Durand CM, 2012, MOL PSYCHIATR, V17, P71, DOI 10.1038/mp.2011.57
   Gauthier J, 2009, AM J MED GENET B, V150B, P421, DOI 10.1002/ajmg.b.30822
   Gauthier J, 2010, P NATL ACAD SCI USA, V107, P7863, DOI 10.1073/pnas.0906232107
   Lim S, 1999, J BIOL CHEM, V274, P29510, DOI 10.1074/jbc.274.41.29510
   Maunakea AK, 2010, NATURE, V466, P253, DOI 10.1038/nature09165
   Mefford HC, 2012, NEW ENGL J MED, V366, P733, DOI 10.1056/NEJMra1114194
   Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
   Naisbitt S, 1999, NEURON, V23, P569, DOI 10.1016/S0896-6273(00)80809-0
   Okamoto N, 2007, AM J MED GENET A, V143A, P2804, DOI 10.1002/ajmg.a.31771
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Phelan MC, 2001, AM J MED GENET, V101, P91, DOI 10.1002/1096-8628(20010615)101:2<91::AID-AJMG1340>3.0.CO;2-C
   Philippe A, 2008, PEDIATRICS, V122, pE376, DOI 10.1542/peds.2007-2584
   Sheng M, 2000, J CELL SCI, V113, P1851
   Sykes NH, 2009, EUR J HUM GENET, V17, P1347, DOI 10.1038/ejhg.2009.47
   Uchino S, 2006, J NEUROCHEM, V97, P1203, DOI 10.1111/j.1471-4159.2006.03831.x
   Waga C, 2011, PSYCHIAT GENET, V21, P208, DOI 10.1097/YPG.0b013e328341e069
   Wang XM, 2011, HUM MOL GENET, V20, P3093, DOI 10.1093/hmg/ddr212
   Yamada Y, 2004, GENOME RES, V14, P247, DOI 10.1101/gr.1351604
NR 28
TC 6
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 106
EP 110
DI 10.1016/j.braindev.2012.05.013
PG 5
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400004
PM 22749736
ER

PT J
AU Yamasue, H
AF Yamasue, Hidenori
TI Function and structure in social brain regions can link
   oxytocin-receptor genes with autistic social behavior
SO BRAIN & DEVELOPMENT
LA English
DT Review
DE Asperger disorder; Functional MRI; Imaging genetics; Neuropeptide;
   Pervasive developmental disorder
ID HEALTHY CAUCASIAN ADULTS; EXTENDED LIMBIC SYSTEM; SPECTRUM DISORDERS;
   OXTR POLYMORPHISM; ASSOCIATION; RS2254298; HUMANS; VOLUME; VASOPRESSIN;
   POPULATION
AB Difficulties in appropriate social and communicative behaviors are the most prevalent and core symptoms of autism spectrum disorders (ASDs). Although recent intensive research has focused on the neurobiological background of these difficulties, many aspects of them were not yet elucidated. Recent studies have employed multimodal magnetic resonance imaging (MRI) indices as intermediate phenotypes of this behavioral phenotype to link candidate genes with the autistic social difficulty. As MRI indices, functional MRI (fMRI), structural MRI, and MR-spectroscopy have been examined in subjects with autism spectrum disorders. As candidate genes, this mini-review has much interest in oxytocin-receptor genes (OXTR), since recent studies have repeatedly reported their associations with normal variations in social cognition and behavior as well as with their extremes, autistic social dysfunction. Through previous increasing studies, medial prefrontal cortex, hypothalamus and amygdala have repeatedly been revealed as neural correlates of autistic social behavior by MRI multimodalities and their relationship to OXTR. For further development of this research area, this mini-review integrates recent accumulating evidence about human behavioral and neural correlates of OXTR. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 [Yamasue, Hidenori] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan.
   [Yamasue, Hidenori] Japan Sci & Technol Agcy, CREST, Chiyoda Ku, Tokyo 1020075, Japan.
RP Yamasue, H (reprint author), Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM yamasue-tky@umin.ac.jp
CR ADDMN Surveillance, 2012, MORBID MORTAL WEEKLY, V61, P1
   Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
   Aoki Y, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2011.65
   Bartz JA, 2011, TRENDS COGN SCI, V15, P301, DOI 10.1016/j.tics.2011.05.002
   Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
   Brune M, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-38
   Campbell DB, 2011, J NEURODEV DISORD, V3, P101, DOI 10.1007/s11689-010-9071-2
   Chelala C, 2009, BIOINFORMATICS, V25, P655, DOI 10.1093/bioinformatics/btn653
   Chen FS, 2011, P NATL ACAD SCI USA, V108, P19937, DOI 10.1073/pnas.1113079108
   Chen FS, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00200
   Furman DJ, 2011, PSYCHONEUROENDOCRINO, V36, P891, DOI 10.1016/j.psyneuen.2010.12.004
   Gimpl G, 2001, PHYSIOL REV, V81, P629
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
   Hammock EAD, 2006, PHILOS T R SOC B, V361, P2187, DOI 10.1098/rstb.2006.1939
   Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
   Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030
   Inoue H, 2010, BIOL PSYCHIAT, V68, P1066, DOI 10.1016/j.biopsych.2010.07.019
   INOUE T, 1994, J BIOL CHEM, V269, P32451
   Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
   Kim HS, 2010, P NATL ACAD SCI USA, V107, P15717, DOI 10.1073/pnas.1010830107
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087
   Liu XX, 2010, J HUM GENET, V55, P137, DOI 10.1038/jhg.2009.140
   Lucht MJ, 2009, PROG NEURO-PSYCHOPH, V33, P860, DOI 10.1016/j.pnpbp.2009.04.004
   Malik AI, 2012, GENES BRAIN BEHAV, V11, P545, DOI 10.1111/j.1601-183X.2012.00776.x
   Meyer-Lindenberg A, 2011, NAT REV NEUROSCI, V12, P524, DOI 10.1038/nrn3044
   Rodrigues SM, 2009, P NATL ACAD SCI USA, V106, P21437, DOI 10.1073/pnas.0909579106
   Tansey KE, 2010, NEUROSCI LETT, V474, P163, DOI 10.1016/j.neulet.2010.03.035
   Tops Mattie, 2011, Front Psychiatry, V2, P60, DOI 10.3389/fpsyt.2011.00060
   Tost H, 2011, BIOL PSYCHIAT, V70, pE37, DOI [10.1016/j.biopsych.2011.06.034, 10.1016/j.biopsych.2011.07.021]
   Tost H, 2010, P NATL ACAD SCI USA, V107, P13936, DOI 10.1073/pnas.1003296107
   van Ijzendoorn MH, 2011, PSYCHONEUROENDOCRINO, V37, P438
   Walter NT, 2012, BRAIN COGNITION, V78, P268, DOI 10.1016/j.bandc.2012.01.003
   Walum H, 2011, BIOL PSYCHIAT, V71, P419
   Watanabe T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039561
   Weintraub K, 2011, NATURE, V479, P22, DOI 10.1038/479022a
   Wu N, 2012, J AFFECT DISORDERS, V138, P468, DOI 10.1016/j.jad.2012.01.009
   Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
   Yamasaki S, 2010, BIOL PSYCHIAT, V68, P1141, DOI 10.1016/j.biopsych.2010.07.012
   Yamasue H, 2009, PSYCHIAT CLIN NEUROS, V63, P129, DOI 10.1111/j.1440-1819.2009.01944.x
   Yamasue H, 2005, NEUROLOGY, V65, P491, DOI 10.1212/01.wnl.0000172360.99310.3f
   Yamasue H, 2011, BIOL PSYCHIAT, V70, pE41, DOI 10.1016/j.biopsych.2011.06.034
   Yrigollen CM, 2008, BIOL PSYCHIAT, V63, P911, DOI 10.1016/j.biopsych.2007.11.015
NR 43
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 111
EP 118
DI 10.1016/j.braindev.2012.08.010
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400005
PM 22986294
ER

PT J
AU Benvenuto, A
   Battan, B
   Porfirio, MC
   Curatolo, P
AF Benvenuto, Arianna
   Battan, Barbara
   Porfirio, Maria Cristina
   Curatolo, Paolo
TI Pharmacotherapy of autism spectrum disorders
SO BRAIN & DEVELOPMENT
LA English
DT Review
DE Autism spectrum disorders; Maladaptive behaviors; Pharmacotherapy; Novel
   targeted treatments
ID PERVASIVE DEVELOPMENTAL DISORDERS; ATTENTION-DEFICIT/HYPERACTIVITY
   DISORDER; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; OPEN-LABEL;
   PHARMACOLOGICAL-TREATMENT; REPETITIVE BEHAVIORS; ADOLESCENT AUTISM;
   CLINICAL-RESPONSE; CROSSOVER TRIAL
AB Although no phauuacological or behavioral therapy has currently proven effective for treating all core symptoms of autism, many dysfunctional behaviors may be treated pharmacologically. Drug treatments should always be part of a comprehensive management plan that includes behavioral and educational interventions, and should be focused on specific targets. Several classes of psychotropic medications have been used to decrease the wide range of "maladaptive" or "interfering" behaviors and associated medical problems that can interfere with relationships and physical health and hinder the implementation of various non-pharmacological interventions. Atypical neuroleptics have been shown to be useful in the treatment of behavioral symptoms in autism. Attention deficit and hyperactivity disorder medications may be effective for counteracting the additional features of hyperactivity and short attention span. Antiepileptic drugs and selective serotonin reuptake inhibitors have shown promising results, but there are no specific indications for them as of yet. With respect to potential drug targets, some clinical features are caused by a dysfunction in neurochemical signaling systems, and thus may improve with selective pharmacological interventions acting on specific abnormal neurobiological pathways. Recent animal studies can be useful models for understanding the common pathogenic pathways leading to autism spectrum disorders (ASDs), and have the potential to offer new biologically focused treatment options. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 [Benvenuto, Arianna; Battan, Barbara; Porfirio, Maria Cristina; Curatolo, Paolo] Univ Roma Tor Vergata, Pediat Neurol Unit, Dept Neurosci, I-00133 Rome, Italy.
RP Curatolo, P (reprint author), Univ Roma Tor Vergata, Pediat Neurol Unit, Dept Neurosci, Via Montpellier 1, I-00133 Rome, Italy.
EM curatolo@uniroma2.it
CR Altemeier WA, 2009, PEDIATR ANN, V38, P167
   Aman MG, 2005, J CHILD ADOL PSYCHOP, V15, P869, DOI 10.1089/cap.2005.15.869
   Aman MG, 2008, J CHILD ADOL PSYCHOP, V18, P227, DOI 10.1089/cap.2007.0133
   Aman MG, 2009, RES DEV DISABIL, V30, P386, DOI 10.1016/j.ridd.2008.07.004
   Anderson GM, 2007, BIOL PSYCHIAT, V61, P545, DOI 10.1016/j.biopsych.2006.02.032
   [Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
   Arnold LE, 2006, J AM ACAD CHILD PSY, V45, P1196, DOI 10.1097/01.chi.0000231976.28719.2a
   Beherec L, 2011, J CLIN PSYCHOPHARM, V31, P341, DOI 10.1097/JCP.0b013e318218f4a1
   Belsito KM, 2001, J AUTISM DEV DISORD, V31, P175, DOI 10.1023/A:1010799115457
   Benvenuto A, 2009, WORLD J PEDIATR, V5, P169, DOI 10.1007/s12519-009-0033-2
   Burket JA, 2011, BRAIN RES BULL, V86, P152, DOI 10.1016/j.brainresbull.2011.08.001
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Charnsil C, 2011, J ATTEN DISORD, V15, P684, DOI 10.1177/1087054710376907
   Chez MG, 2007, J CHILD NEUROL, V22, P574, DOI 10.1177/0883073807302611
   Choudhury PR, 2011, PHARM BIOCH BEHAV
   Currenti SA, 2010, CELL MOL NEUROBIOL, V30, P161, DOI 10.1007/s10571-009-9453-8
   Di Martino A, 2004, J CHILD ADOL PSYCHOP, V14, P207, DOI 10.1089/1044546041649011
   Ehninger D, 2011, TRENDS MOL MED, V17, P78, DOI 10.1016/j.molmed.2010.10.002
   Frazier TW, 2011, J CHILD ADOL PSYCHOP, V21, P571, DOI 10.1089/cap.2011.0057
   Frazier TW, 2010, J CHILD ADOL PSYCHOP, V20, P167, DOI 10.1089/cap.2009.0048
   Frye RE, 2011, BMC PEDIATR, V11, DOI 10.1186/1471-2431-11-37
   Ghanizadeh A, 2011, NEUROSCIENCES, V16, P83
   Green JJ, 2010, NEUROTHERAPEUTICS, V7, P250, DOI 10.1016/j.nurt.2010.05.006
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
   Handen BL, 2008, J DEV BEHAV PEDIATR, V29, P303, DOI 10.1097/DBP.0b013e3181739b9d
   Hardan AY, 2004, J CHILD ADOL PSYCHOP, V14, P426, DOI 10.1089/1044546042389082
   Hartley SL, 2008, J INTELL DISABIL RES, V52, P819, DOI 10.1111/j.1365-2788.2008.01065.x
   Hazell P, 2007, J PAEDIATR CHILD H, V43, P19, DOI 10.1111/j.1440-1754.2007.00995.x
   Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627
   Hollander E, 2006, INT J NEUROPSYCHOPH, V9, P209, DOI 10.1017/S1461145705005791
   Hollander E, 2006, J CHILD ADOL PSYCHOP, V16, P541, DOI 10.1089/cap.2006.16.541
   Hollander E, 2011, AM J PSYCHIAT
   Hollander E, 2010, NEUROPSYCHOPHARMACOL, V35, P990, DOI 10.1038/npp.2009.202
   Jahromi LB, 2009, J AUTISM DEV DISORD, V39, P395, DOI 10.1007/s10803-008-0636-9
   JASELSKIS CA, 1992, J CLIN PSYCHOPHARM, V12, P322
   Kanne SM, 2011, J AUTISM DEV DISORD, V41, P926, DOI 10.1007/s10803-010-1118-4
   Khanna R, 2011, J AUTISM DEV DISORD, V41, P1214, DOI 10.1007/s10803-010-1140-6
   King BH, 2001, J AM ACAD CHILD PSY, V40, P658, DOI 10.1097/00004583-200106000-00010
   King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30
   Kuhlthau K, 2010, J AUTISM DEV DISORD, V40, P721, DOI 10.1007/s10803-009-0921-2
   Lee CH, 2011, EXP NEUROL, V229, P450, DOI 10.1016/j.expneurol.2011.03.015
   Logan SL, 2012, ANN EPIDEMIOL, V22, P1, DOI 10.1016/j.annepidem.2011.10.007
   Malow B, 2011, J AUTISM DEV DISORD
   Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658
   Marcus RN, 2011, J CHILD ADOL PSYCHOP, V21, P229, DOI 10.1089/cap.2009.0121
   Mazzone L, 2006, BRAIN DEV-JPN, V28, P668, DOI 10.1016/j.braindev.2006.05.004
   McClellan JM, 2003, J AM ACAD CHILD PSY, V42, P1388, DOI 10.1097/01.chi.0000092322.84052.88
   McCracken JT, 2010, J CHILD ADOL PSYCHOP, V20, P1, DOI 10.1089/cap.2009.0059
   McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142
   McPheeters ML, 2011, PEDIATRICS, V127, pE1312, DOI 10.1542/peds.2011-0427
   Miano Silvia, 2010, Paediatr Drugs, V12, P75, DOI 10.2165/11316140-000000000-00000
   Ming X, 2008, BRAIN DEV-JPN, V30, P454, DOI 10.1016/j.braindev.2007.12.007
   Miral S, 2008, EUR CHILD ADOLES PSY, V17, P1, DOI 10.1007/s00787-007-0620-5
   Mori T, 2012, BRAIN DEV-JPN, V34, P648, DOI 10.1016/j.braindev.2011.10.007
   Nagaraj R, 2006, J CHILD NEUROL, V21, P450, DOI 10.2310/7010.2006.00099
   Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
   Owley T, 2005, J AM ACAD CHILD PSY, V44, P343, DOI 10.1097/01.chi.0000153229.80215.a0
   Owley T, 2010, AUTISM RES, V3, P1, DOI 10.1002/aur.109
   Palermo MT, 2004, J CHILD NEUROL, V19, P155
   Palmieri L, 2010, MOL PSYCHIATR, V15, P38, DOI 10.1038/mp.2008.63
   Pandina GJ, 2007, J AUTISM DEV DISORD, V37, P367, DOI 10.1007/s10803-006-0234-7
   Posey DJ, 2006, J CHILD ADOL PSYCHOP, V16, P599, DOI 10.1089/cap.2006.16.599
   Posey DJ, 2007, BIOL PSYCHIAT, V61, P538, DOI 10.1016/j.biopsych.2006.09.028
   Quincozes-Santos A, 2009, PROG NEURO-PSYCHOPH, V33, P11, DOI 10.1016/j.pnpbp.2008.08.023
   Research Units on Pediatric Psychopharmacology (RUPP) Autistic Disorder Network, 2005, ARCH GEN PSYCHIAT, V62, P1266
   Rezaei V, 2010, PROG NEURO-PSYCHOPH, V34, P1269, DOI 10.1016/j.pnpbp.2010.07.005
   Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
   Rossignol DA, 2011, DEV MED CHILD NEUROL, V53, P783, DOI 10.1111/j.1469-8749.2011.03980.x
   Rossignol DA, 2009, ANN CLIN PSYCHIATRY, V21, P213
   Rossignol E, 2011, NEURAL PLAST, DOI 10.1155/2011/649325
   Scahill L, 2006, J CHILD ADOL PSYCHOP, V16, P589, DOI 10.1089/cap.2006.16.589
   Schieve L. A., 2011, RES DEV DISABIL, V33, P467
   Selby L, 2007, NEUROSCI LETT, V412, P227, DOI 10.1016/j.neulet.2006.11.062
   Stanford MS, 2009, CURR TREAT OPTION N, V11, P383, DOI 10.1007/s11940-009-0043-3
   Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
   Troost PW, 2006, J CHILD ADOL PSYCHOP, V16, P561, DOI 10.1089/cap.2006.16.561
   Tuchman R, 2010, BRAIN DEV-JPN, V32, P719, DOI 10.1016/j.braindev.2010.05.007
   Veenstra-VanderWeele J, 2012, NEUROPSYCHOPHARMACOL, V37, P196, DOI 10.1038/npp.2011.185
   Vivanti G, 2011, AUTISM
   Walker MA, 2008, EXPERT OPIN THER TAR, V12, P949, DOI [10.1517/14728222.12.8.949 , 10.1517/14728220802198140]
   Wasserman S, 2006, INT CLIN PSYCHOPHARM, V21, P363, DOI 10.1097/01.yic.0000224787.13782.0f
   Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
   West L, 2009, J SPEC PEDIATR NURS, V14, P183, DOI 10.1111/j.1744-6155.2009.00196.x
   West L, 2009, J PEDIATR HEALTH CAR, V23, P75, DOI 10.1016/j.pedhc.2008.12.001
   Williams K, 2010, COCHRANE DB SYST REV, V8
   Zeiner P, 2011, ACTA PAEDIATR, V100, P1258, DOI 10.1111/j.1651-2227.2011.02263.x
NR 86
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 119
EP 127
DI 10.1016/j.braindev.2012.03.015
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400006
PM 22541665
ER

PT J
AU Neville, B
AF Neville, Brian
TI Role of ESSENCE for preschool children with neurodevelopmental disorders
SO BRAIN & DEVELOPMENT
LA English
DT Review
DE Causal pathways; Early developmental disorders
ID DYSKINETIC CEREBRAL-PALSY; HEMIPLEGIA
AB Early Symptomatic Syndromes Eliciting Neurodevelopmental Examinations (ESSENCE) has been proposed as a guide to the neurodevelopmental needs of the under 5s. The problems are their multiplicity, the presence of partial features of specific conditions e.g. autism spectrum disorder and attention deficit/hyperactivity disorder and the young age of the children. For these reasons, child development teams often leave families to cope with very difficult situations. This paper includes epilepsy and the cerebral palsies to see if providing precise diagnostic categories and therapeutic targets cart-be achieved. It includes a discussion of causal sequences which have yet to be applied comprehensively to the neurodevelopment disorders. (C) 2012 Published by Elsevier B.V. on behalf of The Japanese Society of Child Neurology.
C1 [Neville, Brian] UCL Inst Child Hlth, Neurosci Unit, London WC1N 3LU, England.
   [Neville, Brian] Young Epilepsy, Lingfield, Surrey, England.
RP Neville, B (reprint author), UCL Inst Child Hlth, Neurosci Unit, 4-5 Long Yard, London WC1N 3LU, England.
EM b.neville@ich.ucl.ac.uk
CR Bann SH, 2003, DEV MED CHILD NEUROL, V45, P477
   Clark M, 2000, BRAIN, V123, P2160, DOI 10.1093/brain/123.10.2160
   De Vries LS, 1988, FETAL NEONATAL NEURO
   EDEBOLTYSK K, 1989, NEUROPEDIATRICS, V20, P46, DOI 10.1055/s-2008-1071264
   G O'Brien, 2000, BEHAV PHENOTYPES CLI
   Gadian DG, 2000, BRAIN, V123, P499, DOI 10.1093/brain/123.3.499
   GILLBERG C, 1983, J CHILD PSYCHOL PSYC, V24, P377, DOI 10.1111/j.1469-7610.1983.tb00116.x
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Goodman R, 1996, BRIT MED J, V312, P1065
   Horstman HM, 2007, ORTHOPAEDIC MANAGEME, P7
   Kyllerman M, 1977, NEUROPADIATRIE S, V8, pS28
   KYLLERMAN M, 1982, ACTA PAEDIATR SCAND, V71, P551, DOI 10.1111/j.1651-2227.1982.tb09473.x
   KYLLERMAN M, 1983, NEUROPEDIATRICS, V14, P29, DOI 10.1055/s-2008-1059549
   Nelson KB, 2004, LANCET NEUROL, V3, P150, DOI 10.1016/S1474-4422(04)00679-9
   Rikonen R, 1982, NEUROPEDIATRICS, V13, P14
   Stanley F, 2000, CLIN DEV MED, V151
   Wicklund LM, 1990, PERIVENTRICULAR LEUK
   WIKLUND LM, 1990, NEURORADIOLOGY, V32, P179
NR 18
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 128
EP 132
DI 10.1016/j.braindev.2012.06.011
PG 5
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400007
PM 22874529
ER

PT J
AU Estes, A
   Olson, E
   Sullivan, K
   Greenson, J
   Winter, J
   Dawson, G
   Munson, J
AF Estes, Annette
   Olson, Erin
   Sullivan, Katherine
   Greenson, Jessica
   Winter, Jamie
   Dawson, Geraldine
   Munson, Jeffrey
TI Parenting-related stress and psychological distress in mothers of
   toddlers with autism spectrum disorders
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE Autism spectrum disorder; Parents; Distress; Toddlers; Parenting-stress
ID BEHAVIOR PROBLEMS; CHILDREN; HEALTH
AB Background:Parents of children with autism spectrum disorders (ASDs) are at risk for higher stress levels than parents of children with other developmental disabilities and typical development. Recent advances in early diagnosis have resulted in younger children being diagnosed with ASDs but factors associated with parent stress in this age group are not well understood. Aims: The present study examined parenting-related stress and psychological distress in mothers of toddlers with ASD, developmental delay without ASD (DD), and typical development. The impact of child problem behavior and daily living skills on parenting-stress and psychological distress were further investigated. Methods: Participants were part of a larger research study on early ASD intervention. Results: Parent self-report of parenting-related stress and psychological distress was utilized. Parents of toddlers with ASD demonstrated increased parenting-related stress compared with parents of toddlers with DD and typical development. However, psychological distress did not differ significantly between the groups. Child behavior problems, but not daily living skills emerged as a significant predictor of parenting-related stress and psychological distress. This was true for both mothers of children with ASD and DD. Conclusions: These finding suggest that parents' abilities to manage and reduce behavior problems is a critical target for interventions for young children with ASD and DD in order to improve child functioning and decrease parenting-related stress. (C). 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 [Estes, Annette; Greenson, Jessica; Winter, Jamie] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
   [Estes, Annette; Sullivan, Katherine] Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
   [Olson, Erin] Univ Washington, Dept Educ, Seattle, WA 98195 USA.
   [Dawson, Geraldine] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
   [Munson, Jeffrey] Univ Washington, Dept Psychiat, Seattle, WA 98195 USA.
RP Estes, A (reprint author), Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
EM estesa@u.washington.edu
FU ACE (NICHD) [P50 HD055782]; STAART (NIH) [U54 MH066399]
FX This study was supported by grant funding: ACE (NICHD) P50 HD055782 and
   STAART (NIH) U54 MH066399.
CR Altiere MJ, 2009, J INTELLECT DEV DIS, V34, P142, DOI 10.1080/13668250902845202
   Aman M., 1986, ABERRANT BEHAV CHECK
   Aman M. G., 2002, ANNOTATED BIBLIO ABE
   [Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
   Beck A, 2004, J INTELL DISABIL RES, V48, P628, DOI 10.1111/j.1365-2788.2003.00564.x
   Behr S., 1993, COGNITIVE COPING FAM, P151
   Bristol M. M., 1984, SEVERELY HANDICAPPED, P91
   Carter AS, 2009, J CLIN PSYCHOL, V65, P1270, DOI 10.1002/jclp.20634
   Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x
   Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z
   De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
   DEROGATIS LR, 1983, PSYCHOL MED, V13, P595
   Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658
   Gray David E., 1992, Australia and New Zealand Journal of Developmental Disabilities, V18, P83
   Griffith GM, 2010, J AUTISM DEV DISORD, V40, P610, DOI 10.1007/s10803-009-0906-1
   Hall Heather R, 2011, Issues Compr Pediatr Nurs, V34, P4, DOI 10.3109/01460862.2011.555270
   Hastings RP, 2001, J AUTISM DEV DISORD, V31, P327, DOI 10.1023/A:1010799320795
   KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P205, DOI 10.1007/BF01058151
   KONSTANTAREAS MM, 1992, J AUTISM DEV DISORD, V22, P217, DOI 10.1007/BF01058152
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Mandell DS, 2010, PSYCHIAT SERV, V61, P822, DOI 10.1176/appi.ps.61.8.822
   Mullen E, 1995, MULLEN SCALES EARLY
   Naseef R. A., 2001, SPECIAL CHILDREN CHA
   Sawyer MG, 2010, J AUTISM DEV DISORD, V40, P620, DOI 10.1007/s10803-009-0912-3
   Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q
   Schieve LA, 2011, DISABIL HEALTH J, V4, P143, DOI 10.1016/j.dhjo.2010.09.002
   Sharpley CF, 1997, J INTELLECT DEV DIS, V22, P19, DOI 10.1080/13668259700033261
   Shattuck PT, 2009, J AM ACAD CHILD PSY, V48, P474, DOI 10.1097/CHI.0b013e31819b3848
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892
   Yirmiya N, 2005, J CHILD PSYCHOL PSYC, V46, P69, DOI 10.1111/j.1469-7610.2004.00334.x
NR 33
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 133
EP 138
DI 10.1016/j.braindev.2012.10.004
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400008
PM 23146332
ER

PT J
AU Mori, K
   Toda, Y
   Ito, H
   Mori, T
   Goji, A
   Fujii, E
   Miyazaki, M
   Harada, M
   Kagami, S
AF Mori, Kenji
   Toda, Yoshihiro
   Ito, Hiromichi
   Mori, Tatsuo
   Goji, Aya
   Fujii, Emiko
   Miyazaki, Masahito
   Harada, Masafumi
   Kagami, Shoji
TI A proton magnetic resonance spectroscopic study in autism spectrum
   disorders: Amygdala and orbito-frontal cortex
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE Autism; Proton magnetic resonance spectroscopy (H-1-MRS); Amygdala;
   Orbito-frontal cortex
ID PREFRONTAL CORTEX; NEURAL SYSTEMS; BRAIN; HIPPOCAMPUS; METABOLITES;
   IMPAIRMENT; ACTIVATION; CHILDREN
AB We previously reported neural dysfunction in the anterior cingulate cortex and dorsolateral prefrontal cortex in autistic patients using proton magnetic resonance spectroscopy (H-1-MRS). In this investigation, we measured chemical metabolites in the left amygdala and the bilateral orbito-frontal cortex (OFC), which are the main components of the social brain. We also examined the association between these metabolic findings and social abilities in subjects with autism. The study group included 77 autistic patients (3-6 years old; mean age 4.1; 57 boys and 20 girls). The control subjects were 31 children (3-6 years old; mean age 4.0; 23 boys and 8 girls). Conventional proton MR spectra were obtained using the STEAM sequence with parameters of TR = 5 sec and TE = 15 msec by a 1.5-tesla clinical MRI system. We analyzed the concentrations of N-acetylaspartate (NAA), creatine/phosphocreatine (Cr), and choline-containing compounds (Cho) using LCModel (Ver. 6.1). The concentrations of NAA in the left amygdala and the bilateral OFC in autistic patients were significantly decreased compared to those in the control group. In the autistic patients, the NAA concentrations in these regions correlated with their social quotient. These findings suggest the presence of neuronal dysfunction in the amygdala and OFC in autism. Dysfunction in the amygdala and OFC may contribute to the pathogenesis of autism. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 [Mori, Kenji; Kagami, Shoji] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Child Hlth & Nursing, Tokushima 7708503, Japan.
   [Toda, Yoshihiro; Ito, Hiromichi; Mori, Tatsuo; Goji, Aya; Fujii, Emiko; Miyazaki, Masahito] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Pediat, Tokushima 7708503, Japan.
   [Harada, Masafumi] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Radiol, Tokushima 7708503, Japan.
RP Mori, K (reprint author), Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Child Hlth & Nursing, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
EM moriken@clin.med.tokushima-u.ac.jp
CR Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6
   Adolphs R, 2003, BRAIN COGNITION, V52, P61, DOI 10.1016/S0278-2626(03)00009-5
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Anderson SW, 1999, NAT NEUROSCI, V2, P1032
   Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
   BRAND A, 1993, DEV NEUROSCI-BASEL, V15, P289, DOI 10.1159/000111347
   Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27
   BROTHERS L, 1990, BEHAV BRAIN RES, V41, P199, DOI 10.1016/0166-4328(90)90108-Q
   Brunet E, 2000, NEUROIMAGE, V11, P157, DOI 10.1006/nimg.1999.0525
   Casamassimo P, 2006, PEDIATRICS, V118, P2587, DOI 10.1542/peds.2006-2780
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Endo T, 2007, BIOL PSYCHIAT, V62, P1030, DOI 10.1016/j.biopsych.2007.05.015
   Fujii Emiko, 2010, J Med Invest, V57, P35
   GILL SS, 1990, J COMPUT ASSIST TOMO, V14, P497, DOI 10.1097/00004728-199007000-00001
   Harada M, 1999, JMRI-J MAGN RESON IM, V10, P124, DOI 10.1002/(SICI)1522-2586(199908)10:2<124::AID-JMRI3>3.3.CO;2-K
   Haxby JV, 2002, BIOL PSYCHIAT, V51, P59, DOI 10.1016/S0006-3223(01)01330-0
   LEDOUX JE, 1995, ANNU REV PSYCHOL, V46, P209, DOI 10.1146/annurev.psych.46.1.209
   Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
   Owen AM, 1996, CEREB CORTEX, V6, P31, DOI 10.1093/cercor/6.1.31
   Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
   Schoenbaum G, 1999, J NEUROSCI, V19, P1876
   Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
   Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006
   Sparks BF, 2002, NEUROLOGY, V59, P184
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   TEDESCHI G, 1995, NEUROLOGY, V45, P1384
   URENJAK J, 1993, J NEUROSCI, V13, P981
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
NR 28
TC 2
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 139
EP 145
DI 10.1016/j.braindev.2012.09.016
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400009
PM 23114054
ER

PT J
AU Pecorelli, A
   Leoncini, S
   De Felice, C
   Signorini, C
   Cerrone, C
   Valacchi, G
   Ciccoli, L
   Hayek, J
AF Pecorelli, Alessandra
   Leoncini, Silvia
   De Felice, Claudio
   Signorini, Cinzia
   Cerrone, Cosimina
   Valacchi, Giuseppe
   Ciccoli, Lucia
   Hayek, Joussef
TI Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic
   autism
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE Neurodevelopment disorders; Oxidative stress; Free iron; Lipid
   peroxidation; 4-hydroxynonenal protein adducts
ID OXIDATIVE STRESS; SPECTRUM DISORDERS; PRENATAL EXPOSURE;
   LIPID-PEROXIDATION; RETT-SYNDROME; CHILDREN; ERYTHROCYTES; METABOLISM;
   SEVERITY; HYPOXIA
AB A link between oxidative stress and autism spectrum disorders (ASDs) remains controversial with opposing views on its role in the pathogenesis of the disease. We investigated for the first time the levels of non-protein-bound iron (NPBI), a pro-oxidant factor, and 4-hydroxynonenal protein adducts (4-HNE PAs), as a marker of lipid peroxidation-induced protein damage, in classic autism. Patients with classic autism (n = 20, mean age 12.0 +/- 6.2 years) and healthy controls (n = 18, mean age 11.7 +/- 6.5 years) were examined. Intraerythrocyte and plasma NPBI were measured by high performance liquid chromatography (HPLC), and 4-HNE PAs in erythrocyte membranes and plasma were detected by Western blotting. The antioxidant defences were evaluated as erythrocyte glutathione (GSH) levels using a spectrophotometric assay. Intraerythrocyte and plasma NPBI levels were significantly increased (1.98- and 3.56-folds) in autistic patients, as compared to controls (p = 0.0019 and p < 0.0001, respectively); likewise, 4-HNE PAs were significantly higher in erythrocyte membranes and in plasma (1.58- and 1.6-folds, respectively) from autistic patients than controls (p = 0.0043 and p = 0.0001, respectively). Erythrocyte GSH was slightly decreased (-10.34%) in patients compared to controls (p = 0.0215). Our findings indicate an impairment of the redox status in classic autism patients, with a consequent imbalance between oxidative stress and antioxidant defences. Increased levels of NPBI could contribute to lipid peroxidation and, consequently, to increased plasma and erythrocyte membranes 4-HNE PAs thus amplifying the oxidative damage, potentially contributing to the autistic phenotype. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 [Pecorelli, Alessandra; Leoncini, Silvia; Signorini, Cinzia; Ciccoli, Lucia] Univ Siena, Dept Pathophysiol Expt Med & Publ Hlth, I-53100 Siena, Italy.
   [De Felice, Claudio] Azienda Osped Univ Senese, Univ Hosp, Neonatal Intens Care Unit, I-53100 Siena, Italy.
   [Cerrone, Cosimina] Res Training & Rehabil Inst, Siena, Italy.
   [Valacchi, Giuseppe] Univ Ferrara, Dept Evolutionary Biol, I-44100 Ferrara, Italy.
   [Valacchi, Giuseppe] Kyung Hee Univ, Dept Food & Nutr, Seoul, South Korea.
   [Hayek, Joussef] AOUS, Univ Hosp, Child Neuropsychiat Unit, I-53100 Siena, Italy.
RP De Felice, C (reprint author), Azienda Osped Univ Senese, Univ Gen Hosp, Neonatal Intens Care Unit, Viale M Bracci 16, I-53100 Siena, Italy.
EM geniente@gmail.com
CR Adams J, 2009, J TOXICOL, V2009
   Adams JB, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-34
   El-Ansary A, 2010, CLIN BIOCHEM, V43, P63, DOI 10.1016/j.clinbiochem.2009.09.008
   Al-Gadani Y, 2009, CLIN BIOCHEM, V42, P1032, DOI 10.1016/j.clinbiochem.2009.03.011
   Beutler M, 1963, J LAB CLIN MED, V61, P882
   Bowers K, 2011, J NEURODEV DISORD, V3, P132, DOI 10.1007/s11689-011-9077-4
   Brown CM, 2011, PROSTAG LEUKOTR ESS, V84, P25, DOI 10.1016/j.plefa.2010.09.007
   Burstyn I, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-2
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Ciccoli L, 2004, BBA-GEN SUBJECTS, V1672, P203, DOI 10.1016/j.bbagen.2004.04.003
   Comporti M, 2002, FREE RADICAL BIO MED, V32, P568, DOI 10.1016/S0891-5849(02)00759-1
   De Felice C, 2009, FREE RADICAL BIO MED, V47, P440, DOI 10.1016/j.freeradbiomed.2009.05.016
   DODGE JT, 1963, ARCH BIOCHEM BIOPHYS, V100, P119, DOI 10.1016/0003-9861(63)90042-0
   Dubinina EE, 2010, BIOCHEMISTRY-MOSCOW+, V75, P1069, DOI 10.1134/S0006297910090014
   El-Ansary AK, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-63
   Essa MM, 2011, BIOL TRACE ELEM RES
   Gonzalez-Pina R, 2008, NEUROCHEM RES, V33, P912, DOI 10.1007/s11064-007-9534-3
   Gueraud F, 2010, FREE RADICAL RES, V44, P1098, DOI 10.3109/10715762.2010.498477
   Guxens M, 2012, ENVIRON HEALTH PERSP, V120, P144, DOI 10.1289/ehp.1103469
   Halliwell B., 2007, FREE RADICALS BIOL M
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   Hermawati D, 2011, ASIA PACIFIC J MOL M, V1, P2
   Hougaard KS, 2008, PART FIBRE TOXICOL, V5, DOI 10.1186/1743-8977-5-3
   Ichim TE, 2007, J TRANSL MED, V5, DOI 10.1186/1479-5876-5-30
   James SJ, 2009, FASEB J, V23, P2374, DOI 10.1096/fj.08-128926
   James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366
   Jomova K, 2010, MOL CELL BIOCHEM, V345, P91, DOI 10.1007/s11010-010-0563-x
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
   McGinnis WR, 2004, ALTERN THER HEALTH M, V10, P22
   Meguid NA, 2011, BIOL TRACE ELEM RES, V143, P58, DOI 10.1007/s12011-010-8840-9
   Melnyk S, 2011, J AUTISM DEV DISORD
   Ming X, 2010, BRAIN DEV-JPN, V32, P105, DOI 10.1016/j.braindev.2008.12.017
   Mostafa GA, 2010, J NEUROIMMUNOL, V219, P114, DOI 10.1016/j.jneuroim.2009.12.003
   Palmieri L, 2010, BBA-BIOENERGETICS, V1797, P1130, DOI 10.1016/j.bbabio.2010.04.018
   Papanikolaou G, 2005, TOXICOL APPL PHARM, V202, P199, DOI 10.1016/j.taap.2004.06.021
   Parellada M, 2011, J PSYCHIAT RES
   Pecorelli A, 2011, CLIN BIOCHEM, V44, P368, DOI 10.1016/j.clinbiochem.2011.01.007
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Signorini C, 2011, CLIN CHIM ACTA, V412, P1399, DOI 10.1016/j.cca.2011.04.016
   Sogut S, 2003, CLIN CHIM ACTA, V331, P111, DOI 10.1016/S0009-8981(03)00119-0
   Volk HE, 2011, ENVIRON HEALTH PERSP, V119, P873, DOI 10.1289/ehp.1002835
   Weintraub K, 2011, NATURE, V479, P22, DOI 10.1038/479022a
   Yorbik O, 2002, PROSTAGLANDINS LEUKO, V67, P341
   Zoroglu SS, 2004, EUR ARCH PSY CLIN N, V254, P143, DOI 10.1007/s00406-004-0456-7
NR 45
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 146
EP 154
DI 10.1016/j.braindev.2012.03.011
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400010
PM 22534237
ER

PT J
AU Miyajima, T
   Kumada, T
   Saito, K
   Fujii, T
AF Miyajima, Tomoko
   Kumada, Tomohiro
   Saito, Keiko
   Fujii, Tatsuya
TI Autism in siblings with autosomal dominant nocturnal frontal lobe
   epilepsy
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE Autosomal dominant nocturnal frontal lobe epilepsy; Autism spectrum
   disorder; Mental retardation
ID MUTATIONS
AB In 1999, Hirose et al. reported a Japanese family with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) associated with a neuronal nicotinic acetylcholine receptor alpha 4 subunit mutation (S252L). We followed the siblings of this family, and found that the elder brother had Asperger's disorder without mental retardation (MR) and the younger brother had autistic disorder with profound MR. The clinical epileptic features of the siblings were very similar, and both had deficits in socialization, but their cognitive development differed markedly. It thus seems that epilepsy is the direct phenotype of the S252L mutation, whereas other various factors modulate the cognitive and social development. No patients with ADNFLE have previously been reported to have autism spectrum disorder or profound MR. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 [Miyajima, Tomoko; Kumada, Tomohiro; Saito, Keiko; Fujii, Tatsuya] Shiga Med Ctr Children, Dept Pediat, Shiga 5240022, Japan.
RP Miyajima, T (reprint author), Shiga Med Ctr Children, Dept Pediat, 5-7-30 Moriyama, Shiga 5240022, Japan.
EM miyajima@terra.dti.ne.jp
CR Cho YW, 2003, ARCH NEUROL-CHICAGO, V60, P1625, DOI 10.1001/archneur.60.11.1625
   Derry CP, 2008, EPILEPSIA, V49, P2125, DOI 10.1111/j.1528-1167.2008.01652.x
   Hirose S, 1999, NEUROLOGY, V53, P1749
   Ito M, 2000, EPILEPSIA, V41, P52, DOI 10.1111/j.1528-1157.2000.tb01505.x
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Magnusson A, 2003, PSYCHIAT GENET, V13, P91, DOI 10.1097/01.ypg.0000056173.32550.b0
   Miyake K, 1989, KINDER INFANT DEV SC
   Phillips HA, 2000, ANN NEUROL, V48, P264, DOI 10.1002/1531-8249(200008)48:2<264::AID-ANA20>3.0.CO;2-B
   Picard F, 2009, EPILEPSY BEHAV, V14, P354, DOI 10.1016/j.yebeh.2008.11.003
   SCHEFFER IE, 1995, BRAIN, V118, P61, DOI 10.1093/brain/118.1.61
   Steinlein OK, 2012, SEIZURE-EUR J EPILEP, V21, P118, DOI 10.1016/j.seizure.2011.10.003
NR 11
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD FEB
PY 2013
VL 35
IS 2
BP 155
EP 157
DI 10.1016/j.braindev.2012.07.012
PG 3
WC Clinical Neurology
SC Neurosciences & Neurology
GA 086GZ
UT WOS:000314673400011
PM 22883468
ER

PT J
AU Narcisa, V
   Discenza, M
   Vaccari, E
   Rosen-Sheidley, B
   Hardan, AY
   Couchon, E
AF Narcisa, Vivien
   Discenza, Marie
   Vaccari, Erica
   Rosen-Sheidley, Beth
   Hardan, Antonio Y.
   Couchon, Elizabeth
TI Parental Interest in a Genetic Risk Assessment Test for Autism Spectrum
   Disorders
SO CLINICAL PEDIATRICS
LA English
DT Article
DE autism; survey; autism spectrum disorders; genetics
ID SOCIOECONOMIC-STATUS; DIAGNOSIS; CHILDREN; INTERVENTION; PREVALENCE;
   CALIFORNIA; RECURRENCE
AB To better understand parental opinions regarding the diagnostic process and use of genetic testing to assess risk for autism spectrum disorders (ASDs) in the younger siblings of affected children in the Unites States, we conducted a survey of parents who had at least one child with ASD. A total of 162 surveys were completed anonymously using an Internet-based survey tool. The mean reported time to ASD diagnosis and age at diagnosis were 35.2 months and 56.6 months, respectively. Seventy-two percent of parents felt there was a delay in diagnosis. Most parents indicated they would want to pursue genetic testing if a test were available that could identify risk in a younger sibling (80%). Earlier evaluation/intervention, closer monitoring, and lessened anxiety were reasons cited for testing. Our survey indicates most parents would pursue genetic risk assessment testing in children at high risk for ASD.
C1 [Narcisa, Vivien] Arcadia Univ, Glenside, PA USA.
   [Discenza, Marie; Vaccari, Erica] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Rosen-Sheidley, Beth] Boston Childrens Hosp, Boston, MA USA.
   [Hardan, Antonio Y.] Stanford Univ, Stanford, CA 94305 USA.
   [Couchon, Elizabeth] IntegraGen Inc, Cambridge, MA 02141 USA.
RP Couchon, E (reprint author), IntegraGen Inc, Med Sci Liaison, 2 Canal Pk,5th Floor, Cambridge, MA 02141 USA.
EM elizabeth.couchon@integragen.com
FU IntegraGen, Inc; IntegraGen, Inc, Cambridge, Massachusetts
FX The authors declared the following potential conflicts of interest with
   respect to the research, authorship, and/or publication of this article:
   E. Couchon is an employee of IntegraGen, Inc, V. Narcisa, M. Discenza,
   and E. Vaccari received financial compensation from IntegraGen, Inc,
   associated with their support of this project. A. Hardan and B.
   Rosen-Sheidley are paid consultants to IntegraGen, Inc. This project was
   neither reviewed nor endorsed by Arcadia University, the Boston
   University School of Medicine, Boston Children's Hospital or Stanford
   University.This survey was sponsored by IntegraGen, Inc, Cambridge,
   Massachusetts.
CR Avdi E, 2000, BRIT J MED PSYCHOL, V73, P327, DOI 10.1348/000711200160543
   Ben Itzchak E, 2008, RES DEV DISABIL, V29, P447, DOI 10.1016/j.ridd.2007.08.003
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
   Constantino JN, 2013, MOL PSYCHIATR, V18, P137, DOI 10.1038/mp.2012.9
   Daniels AM, 2012, J AUTISM DEV DISORD, V42, P257, DOI 10.1007/s10803-011-1236-7
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Harrington JW, 2006, J DEV BEHAV PEDIATR, V27, pS156, DOI 10.1097/00004703-200604002-00014
   Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   King MD, 2011, AM SOCIOL REV, V76, P320, DOI 10.1177/0003122411399389
   Kuehn BM, 2012, JAMA-J AM MED ASSOC, V307, P2137, DOI 10.1001/jama.2012.3916
   Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Pinborough-Zimmerman J, 2011, AUTISM RES, V4, P438, DOI 10.1002/aur.224
   Pisula E., 2003, ARCH PSYCHIAT PSYCHO, V5, P51
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Rosenberg R. R., 2011, AUTISM RES TREAT, V2011, DOI DOI 10.1155/2011/874619
   Sivberg Bengt, 2003, J Pediatr Nurs, V18, P433, DOI 10.1016/S0882-5963(03)00139-8
   Soares I., 1993, COMMUNICATION, V27, P17
   Thomas P, 2012, AUTISM, V16, P201, DOI 10.1177/1362361311413397
   Vande Wydeven K, 2012, J GENET COUNS, V21, P803, DOI 10.1007/s10897-012-9494-x
   Van Meter KC, 2010, AUTISM RES, V3, P19, DOI 10.1002/aur.110
   Weiss JA, 2012, AUTISM, V16, P261, DOI 10.1177/1362361311422708
   Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005
NR 27
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0009-9228
J9 CLIN PEDIATR
JI Clin. Pediatr.
PD FEB
PY 2013
VL 52
IS 2
BP 139
EP 146
DI 10.1177/0009922812466583
PG 8
WC Pediatrics
SC Pediatrics
GA 083OV
UT WOS:000314475300005
PM 23193169
ER

PT J
AU Arborelius, L
   Fors, U
   Svensson, AK
   Sygel, K
   Kristiansson, M
AF Arborelius, Lotta
   Fors, Uno
   Svensson, Anna-Karin
   Sygel, Kristina
   Kristiansson, Marianne
TI A new interactive computer simulation system for violence risk
   assessment of mentally disordered violent offenders
SO CRIMINAL BEHAVIOUR AND MENTAL HEALTH
LA English
DT Article
ID PSYCHOPATHY CHECKLIST
AB Background Assessment of risk of future violence has developed from reliance on static indicators towards a more dynamic approach. In the latter context, however, the offender is seldom confronted with real life situations. Aims The aim of this study is to evaluate a computer-based system Reactions on Display, which presents human interactions based on real-life situations for its effectiveness in distinguishing between potentially violent offenders with mental disorder and a healthy comparison group. Methods Male offenders with autism spectrum disorders or psychosis were recruited from specialist forensic psychiatric units in Sweden and healthy participants from the local communities. Each consenting participant was presented with film clips of a man in neutral and violent situations, which at critical moments stopped the story to ask him to predict the thoughts, feelings and actions of the actor. Results Offender patients, irrespective of diagnosis, detected fewer emotional reactions in the actor in the non-violent sequence compared with controls. When asked to choose one of four violent actions, the offender patients chose more violent actions than did the controls. They also reported fewer physical reactions in the actors when actors were being violent. There were also some examples of incongruent or deviant responses by some individual patients. Conclusions and implications for practice The use of interactive computer simulation techniques is not only generally acceptable to offender patients, but it also helps to differentiate their current response style to particular circumstances from that of healthy controls in a way that does not rely on their verbal abilities and may tap more effectively into their emotional reactions than standard verbal questions and answer approaches. This may pave the way for Reactions on Display providing a useful complement to traditional risk assessment, and a training route with respect to learning more empathic responding, thus having a role in aiding risk management.Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Arborelius, Lotta] Karolinska Inst, Div Psychol, Dept Clin Neurosci, Stockholm, Sweden.
   [Fors, Uno] Stockholm Univ, Dept Comp & Syst Sci, S-10691 Stockholm, Sweden.
   [Svensson, Anna-Karin; Sygel, Kristina; Kristiansson, Marianne] Karolinska Inst, Div Social & Forens Psychiat, Dept Clin Neurosci, Stockholm, Sweden.
   [Sygel, Kristina; Kristiansson, Marianne] Natl Board Forens Med, Dept Forens Psychiat, Stockholm, Sweden.
RP Fors, U (reprint author), Stockholm Univ, Dept Comp & Syst Sci, Forum 100, S-16440 Kista, Sweden.
EM Uno@dsv.su.se
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   de Vignemont F, 2006, TRENDS COGN SCI, V10, P435, DOI 10.1016/j.tics.2006.08.008
   Dolan M, 2000, BRIT J PSYCHIAT, V177, P303, DOI 10.1192/bjp.177.4.303
   Douglas KS, 1999, J CONSULT CLIN PSYCH, V67, P917, DOI 10.1037/0022-006X.67.6.917
   Eippert F, 2007, HUM BRAIN MAPP, V28, P409, DOI 10.1002/hbm.20291
   Haskins BG, 2006, J AM ACAD PSYCHIATRY, V34, P374
   Kleinman J, 2001, J AUTISM DEV DISORD, V31, P29, DOI 10.1023/A:1005657512379
   Kristiansson M., 2008, CLIN NEUROPSYCHIATRY, V5, P55
   Levenson RW, 2003, ANN NY ACAD SCI, V1000, P348, DOI 10.1196/annals.1280.016
   Murphy David, 2006, Cogn Neuropsychiatry, V11, P99, DOI 10.1080/13546800444000182
   Rogers K, 2007, J AUTISM DEV DISORD, V37, P709, DOI 10.1007/s10803-006-0197-8
   Wahlund K, 2009, PSYCHIAT RES, V180, P30
   Webster C. D., 1997, HCR 20 ASSESSING RIS
   WHO, 1988, INT CLASS DIS
   Wijk L, 2009, INFORM HEALTH SOC CA, V34, P106, DOI 10.1080/17538150903014395
NR 15
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0957-9664
J9 CRIM BEHAV MENT HEAL
JI Crim. Behav. Ment. Health
PD FEB
PY 2013
VL 23
IS 1
BP 30
EP 40
DI 10.1002/cbm.1849
PG 11
WC Criminology & Penology; Psychiatry
SC Criminology & Penology; Psychiatry
GA 086AB
UT WOS:000314654300004
PM 23297032
ER

PT J
AU Graham, SA
   Fisher, SE
AF Graham, Sarah A.
   Fisher, Simon E.
TI Decoding the genetics of speech and language
SO CURRENT OPINION IN NEUROBIOLOGY
LA English
DT Article
ID DYSLEXIA SUSCEPTIBILITY GENE; AUTISM SPECTRUM DISORDER; ALTERED BRAIN
   ACTIVATION; BASAL GANGLIA CIRCUITS; IN-UTERO RNAI; DEVELOPMENTAL
   DYSLEXIA; NEURONAL MIGRATION; FOXP2 GENE; ULTRASONIC VOCALIZATION;
   AUSTRALIAN POPULATION
AB Researchers are beginning to uncover the neurogenetic pathways that underlie our unparalleled capacity for spoken language. Initial clues come from identification of genetic risk factors implicated in developmental language disorders. The underlying genetic architecture is complex, involving a range of molecular mechanisms. For example, rare protein-coding mutations of the FOXP2 transcription factor cause severe problems with sequencing of speech sounds, while common genetic risk variants of small effect size in genes like CNTNAP2, ATP2C2 and CMIP are associated with typical forms of language impairment. In this article, we describe how investigations of these and other candidate genes, in humans, animals and cellular models, are unravelling the connections between genes and cognition. This depends on interdisciplinary research at multiple levels, from determining molecular interactions and functional roles in neural cell-biology all the way through to effects on brain structure and activity.
C1 [Graham, Sarah A.; Fisher, Simon E.] Max Planck Inst Psycholinguist, Language & Genet Dept, NL-6525 XD Nijmegen, Netherlands.
   [Fisher, Simon E.] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 EN Nijmegen, Netherlands.
RP Fisher, SE (reprint author), Max Planck Inst Psycholinguist, Language & Genet Dept, Wundtlaan 1, NL-6525 XD Nijmegen, Netherlands.
EM simon.fisher@mpi.nl
RI Fisher, Simon/E-9130-2012; Graham, Sarah/G-7765-2014
OI Fisher, Simon/0000-0002-3132-1996; Graham, Sarah/0000-0003-2521-2416
CR Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
   Anthoni H, 2012, BEHAV GENET, V42, P509, DOI 10.1007/s10519-012-9532-3
   Arriaga G, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046610
   Bacon C, 2012, HUM GENET, V131, P1687, DOI 10.1007/s00439-012-1193-z
   Bates TC, 2011, BEHAV GENET, V41, P50, DOI 10.1007/s10519-010-9402-9
   Bates TC, 2010, MOL PSYCHIATR, V15, P1190, DOI 10.1038/mp.2009.120
   Belton E, 2003, HUM BRAIN MAPP, V18, P194, DOI 10.1002/hbm.10093
   Buonincontri R, 2011, BEHAV GENET, V41, P125, DOI 10.1007/s10519-010-9389-2
   Coop G, 2008, MOL BIOL EVOL, V25, P1257, DOI 10.1093/molbev/msn091
   Cope N, 2012, NEUROIMAGE, V63, P148, DOI 10.1016/j.neuroimage.2012.06.037
   Darki F, 2012, BIOL PSYCHIAT, V72, P671, DOI 10.1016/j.biopsych.2012.05.008
   Dennis Emily L, 2011, Brain Connect, V1, P447, DOI 10.1089/brain.2011.0064
   Dennis MY, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000436
   Enard W, 2009, CELL, V137, P961, DOI 10.1016/j.cell.2009.03.041
   Enard W, 2002, NATURE, V418, P869, DOI 10.1038/nature01025
   Enard W, 2011, CURR OPIN NEUROBIOL, V21, P415, DOI 10.1016/j.conb.2011.04.008
   Ferland RJ, 2003, J COMP NEUROL, V460, P266, DOI 10.1002/cne.10654
   Fisher SE, 2002, NAT GENET, V30, P86, DOI 10.1038/ng792
   Fisher SE, 1998, NAT GENET, V18, P168, DOI 10.1038/ng0298-168
   Fisher SE, 2009, TRENDS GENET, V25, P166, DOI 10.1016/j.tig.2009.03.002
   Fisher SE, 2006, NAT REV GENET, V7, P9, DOI 10.1038/nrg1747
   French CA, 2007, GENESIS, V45, P440, DOI 10.1002/dvg.20305
   French CA, 2012, MOL PSYCHIATR, V17, P1077, DOI 10.1038/mp.2011.105
   Fujita E, 2008, P NATL ACAD SCI USA, V105, P3117, DOI 10.1073/pnas.0712298105
   Gabel LA, 2011, GENES BRAIN BEHAV, V10, P868, DOI 10.1111/j.1601-183X.2011.00727.x
   GALABURDA AM, 1985, ANN NEUROL, V18, P222, DOI 10.1002/ana.410180210
   Gaub S, 2010, GENES BRAIN BEHAV, V9, P390, DOI 10.1111/j.1601-183X.2010.00570.x
   Girotto G, 2011, J MED GENET, V48, P369, DOI 10.1136/jmg.2010.088310
   Groszer M, 2008, CURR BIOL, V18, P354, DOI 10.1016/j.cub.2008.01.060
   Haesler S, 2007, PLOS BIOL, V5, P2885, DOI 10.1371/journal.pbio.0050321
   Hammerschmidt K, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-40
   Hannula-Jouppi K, 2005, PLOS GENET, V1, P467, DOI 10.1371/journal.pgen.0010050
   Hilliard AT, 2012, NEURON, V73, P537, DOI 10.1016/j.neuron.2012.01.005
   Horng S, 2009, J NEUROSCI, V29, P13672, DOI 10.1523/JNEUROSCI.2127-09.2009
   Jamadar S, 2012, BRAIN IMAGING B 0605
   Kikusui T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017721
   Konopka G, 2009, NATURE, V462, P213, DOI 10.1038/nature08549
   Krause J, 2007, CURR BIOL, V17, P1908, DOI 10.1016/j.cub.2007.10.008
   Kurt S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033130
   Kurt S, 2009, BRAIN RES, V1289, P30, DOI 10.1016/j.brainres.2009.06.092
   Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
   Lai CSL, 2003, BRAIN, V126, P2455, DOI 10.1093/brain/awg247
   Lamminmaki S, 2012, J NEUROSCI, V32, P966, DOI 10.1523/JNEUROSCI.4007-11.2012
   Lennon PA, 2007, AM J MED GENET A, V143A, P791, DOI 10.1002/ajmg.a.31632
   Liegeois F, 2003, NAT NEUROSCI, V6, P1230, DOI 10.1038/nn1138
   Lind PA, 2010, EUR J HUM GENET, V18, P668, DOI 10.1038/ejhg.2009.237
   MacDermot KD, 2005, AM J HUM GENET, V76, P1074, DOI 10.1086/430841
   Massinen S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020580
   Matsson H, 2011, BEHAV GENET, V41, P134, DOI 10.1007/s10519-010-9431-4
   Meng HY, 2011, BEHAV GENET, V41, P58, DOI 10.1007/s10519-010-9408-3
   Mukamel Z, 2011, J NEUROSCI, V31, P11437, DOI 10.1523/JNEUROSCI.0181-11.2011
   Newbury DF, 2010, NEURON, V68, P309, DOI 10.1016/j.neuron.2010.10.001
   Newbury DF, 2002, AM J HUM GENET, V70, P1318, DOI 10.1086/339931
   Newbury DF, 2011, BEHAV GENET, V41, P90, DOI 10.1007/s10519-010-9424-3
   Newbury DF, 2009, AM J HUM GENET, V85, P264, DOI 10.1016/j.ajhg.2009.07.004
   Newbury DF, 2005, TRENDS COGN SCI, V9, P528, DOI 10.1016/j.tics.2005.09.002
   Nopola-Hemmi J, 2001, J MED GENET, V38, P658, DOI 10.1136/jmg.38.10.658
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Paracchini S, 2008, AM J PSYCHIAT, V165, P1576, DOI 10.1176/appi.ajp.2008.07121872
   Paracchini S, 2006, HUM MOL GENET, V15, P1659, DOI 10.1093/hmg/ddl089
   Paracchini S, 2011, GENES BRAIN BEHAV, V10, P158, DOI 10.1111/j.1601-183X.2010.00651.x
   Penagarikano O, 2012, TRENDS MOL MED, V18, P156, DOI 10.1016/j.molmed.2012.01.003
   Pennington BF, 2009, ANNU REV PSYCHOL, V60, P283, DOI 10.1146/annurev.psych.60.110707.163548
   Peschansky VJ, 2010, CEREB CORTEX, V20, P884, DOI 10.1093/cercor/bhp154
   Peter B, 2011, J NEURODEV DISORD, V3, P39, DOI 10.1007/s11689-010-9065-0
   Pinel P, 2012, J NEUROSCI, V32, P817, DOI 10.1523/JNEUROSCI.5996-10.2012
   Ptak SE, 2009, MOL BIOL EVOL, V26, P2181, DOI 10.1093/molbev/msp143
   Reimers-Kipping S, 2011, NEUROSCIENCE, V175, P75, DOI 10.1016/j.neuroscience.2010.11.042
   Roll P, 2010, HUM MOL GENET, V19, P4848, DOI 10.1093/hmg/ddq415
   Santos ME, 2011, MOL BIOL EVOL, V28, P237, DOI 10.1093/molbev/msq182
   Scerri TS, 2011, BIOL PSYCHIAT, V70, P237, DOI 10.1016/j.biopsych.2011.02.005
   Scerri TS, 2010, EUR CHILD ADOLES PSY, V19, P179, DOI 10.1007/s00787-009-0081-0
   Scerri TS, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013712
   Schulz SB, 2010, GENES BRAIN BEHAV, V9, P732, DOI 10.1111/j.1601-183X.2010.00607.x
   Scott-Van Zeeland AA, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3001344
   Shriberg LD, 2006, J SPEECH LANG HEAR R, V49, P500, DOI 10.1044/1092-4388(2006/038)
   Shu WG, 2005, P NATL ACAD SCI USA, V102, P9643, DOI 10.1073/pnas.0503739102
   Simpson JH, 2000, NEURON, V28, P753, DOI 10.1016/S0896-6273(00)00151-3
   Spiteri E, 2007, AM J HUM GENET, V81, P1144, DOI 10.1086/522237
   Strauss KA, 2006, NEW ENGL J MED, V354, P1370, DOI 10.1056/NEJMoa052773
   Szalkowski CE, 2011, GENES BRAIN BEHAV, V10, P244, DOI 10.1111/j.1601-183X.2010.00662.x
   Szalkowski CE, 2012, INT J DEV NEUROSCI, V30, P293, DOI 10.1016/j.ijdevneu.2012.01.009
   Taipale M, 2003, P NATL ACAD SCI USA, V100, P11553, DOI 10.1073/pnas.1833911100
   Tammimies K, 2012, BIOL PSYCHIAT
   Teramitsu I, 2006, J NEUROSCI, V26, P7390, DOI 10.1523/JNEUROSCI.1662-06.2006
   Teramitsu I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008548
   Teramitsu I, 2004, J NEUROSCI, V24, P3152, DOI 10.1523/JNEUROSCI.5589-03.2004
   Tomblin JB, 2009, J SPEECH LANG HEAR R, V52, P1157, DOI 10.1044/1092-4388(2009/07-0162)
   Van der Aa N, 2012, AUTISM RES, V5, P277, DOI 10.1002/aur.1240
   Velayos-Baeza A, 2010, J BIOL CHEM, V285, P40148, DOI 10.1074/jbc.M110.145961
   Vernes SC, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002145
   Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
   Vernes SC, 2007, AM J HUM GENET, V81, P1232, DOI 10.1086/522238
   Vernes SC, 2006, HUM MOL GENET, V15, P3154, DOI 10.1093/hmg/ddl392
   Walker RM, 2012, HUM MOL GENET, V21, P2862, DOI 10.1093/hmg/dds111
   Wang Y, 2006, NEUROSCIENCE, V143, P515, DOI 10.1016/j.neuroscience.2006.08.022
   Watkins KE, 2002, BRAIN, V125, P452, DOI 10.1093/brain/awf058
   Watkins KE, 2002, BRAIN, V125, P465, DOI 10.1093/brain/awf057
   Whalley HC, 2011, AM J MED GENET B, V156B, P941, DOI 10.1002/ajmg.b.31241
   Whitehouse AJO, 2011, GENES BRAIN BEHAV, V10, P451, DOI 10.1111/j.1601-183X.2011.00684.x
   Xing LY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043968
   Zeesman S, 2006, AM J MED GENET A, V140A, P509, DOI 10.1002/ajmg.a.31110
   Zhang YP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042969
   Zou L, 2012, AM J MED GENET B, V159B, P970, DOI 10.1002/ajmg.b.32102
NR 104
TC 30
Z9 30
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0959-4388
EI 1873-6882
J9 CURR OPIN NEUROBIOL
JI Curr. Opin. Neurobiol.
PD FEB
PY 2013
VL 23
IS 1
BP 43
EP 51
DI 10.1016/j.conb.2012.11.006
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 084TV
UT WOS:000314562900008
PM 23228431
ER

PT J
AU Flint, J
   Munafo, MR
AF Flint, Jonathan
   Munafo, Marcus R.
TI Candidate and non-candidate genes in behavior genetics
SO CURRENT OPINION IN NEUROBIOLOGY
LA English
DT Article
ID SEROTONIN TRANSPORTER GENE; DE-NOVO MUTATIONS; AUTISM SPECTRUM
   DISORDERS; STRESSFUL LIFE EVENTS; COMMON VARIANTS; PROMOTER
   POLYMORPHISM; 5-HTTLPR; DEPRESSION; MODERATION; SCHIZOPHRENIA
AB In this review we discuss recent developments in psychiatric genetics: on the one hand, studies using whole genome approaches (genome-wide association studies (GWAS) and exome sequencing) are coming close to finding genes and molecular variants that contribute to disease susceptibility; on the other candidate genes, such as the serotonin transporter, continue to dominate in genetic studies of brain imaging phenotypes and in protracted searches for gene by environment interactions. These two areas intersect, in that new information about genetic effects from whole genome approaches, should (but does not always) inform the single locus analyses.
C1 [Flint, Jonathan] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
   [Munafo, Marcus R.] Univ Bristol, Sch Expt Psychol, Bristol BS8 1TU, Avon, England.
RP Flint, J (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford, England.
EM jf@well.ox.ac.uk
CR Allen HL, 2010, NATURE, V467, P832, DOI 10.1038/nature09410
   Beevers CG, 2011, J ABNORM PSYCHOL, V120, P187, DOI 10.1037/a0022125
   Bis JC, 2012, NAT GENET, V44, P545, DOI 10.1038/ng.2237
   Caspers KM, 2009, DEV PSYCHOL, V45, P64, DOI 10.1037/a0014026
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Caspi A, 2010, AM J PSYCHIAT, V167, P509, DOI 10.1176/appi.ajp.2010.09101452
   Duncan LE, 2011, AM J PSYCHIAT, V168, P1041, DOI 10.1176/appi.ajp.2011.11020191
   Fergusson DM, 2011, BRIT J PSYCHIAT, V198, P129, DOI 10.1192/bjp.bp.110.085993
   Gelman A, 2009, AM SCI, V97, P310
   Gibbons FX, 2012, DEV PSYCHOL, V48, P722, DOI 10.1037/a0026599
   Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
   Hariri AR, 2002, SCIENCE, V297, P400, DOI 10.1126/science.1071829
   Hayden EP, 2010, EMOTION, V10, P696, DOI 10.1037/a0019527
   Hindorff LA, 2009, P NATL ACAD SCI USA, V106, P9362, DOI 10.1073/pnas.0903103106
   Ikram MA, 2012, NAT GENET, V44, P539, DOI 10.1038/ng.2245
   Ioannidis JPA, 2011, ARCH GEN PSYCHIAT, V68, P773, DOI 10.1001/archgenpsychiatry.2011.28
   Ioannidis JPA, 2007, CLIN TRIALS, V4, P245, DOI 10.1177/1740774507079441
   Karg K, 2011, ARCH GEN PSYCHIAT, V68, P444, DOI 10.1001/archgenpsychiatry.2010.189
   Kaufman Joan, 2010, Biol Psychiatry, V67, pe19, DOI 10.1016/j.biopsych.2009.07.041
   Kaufman J, 2010, BIOL PSYCHIAT, pe21
   KENDLER KS, 1995, AM J PSYCHIAT, V152, P833
   Kogan SM, 2010, HEALTH PSYCHOL, V29, P471, DOI 10.1037/a0020594
   Lee SH, 2012, NAT GENET, V44, P247, DOI 10.1038/ng.1108
   Martin J, 2007, MOL PSYCHIATR, V12, P421, DOI 10.1038/sj.mp.4001952
   McGuffin P, 2011, BRIT J PSYCHIAT, V198, P424, DOI 10.1192/bjp.bp.110.085225
   Mier D, 2010, MOL PSYCHIATR, V15, P918, DOI 10.1038/mp.2009.36
   Munafo MR, 2009, BIOL PSYCHIAT, V65, P211, DOI 10.1016/j.biopsych.2008.06.009
   Murphy S. E., 2012, MOL PSYCHIAT
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Panagiotou OA, 2012, J CLIN EPIDEMIOL, V65, P740, DOI 10.1016/j.jclinepi.2012.01.008
   Risch N, 2009, JAMA-J AM MED ASSOC, V301, P2462, DOI 10.1001/jama.2009.878
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Schoebi D, 2012, EMOTION, V12, P208, DOI 10.1037/a0026067
   Song ZL, 2011, J APPL PSYCHOL, V96, P1223, DOI 10.1037/a0024577
   Stein JL, 2012, NAT GENET, V44, P552, DOI 10.1038/ng.2250
   Sulik MJ, 2012, DEV PSYCHOL, V48, P740, DOI 10.1037/a0025938
   Taal HR, 2012, NAT GENET, V44, P532, DOI 10.1038/ng.2238
   Visscher PM, 2012, MOL PSYCHIATR, V17, P474, DOI 10.1038/mp.2011.65
   Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
NR 41
TC 22
Z9 22
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0959-4388
J9 CURR OPIN NEUROBIOL
JI Curr. Opin. Neurobiol.
PD FEB
PY 2013
VL 23
IS 1
BP 57
EP 61
DI 10.1016/j.conb.2012.07.005
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA 084TV
UT WOS:000314562900010
PM 22878161
ER

PT J
AU Crespi, B
AF Crespi, Bernard
TI Diametric gene-dosage effects as windows into neurogenetic architecture
SO CURRENT OPINION IN NEUROBIOLOGY
LA English
DT Article
ID 17Q21.31 MICRODELETION SYNDROME; PRADER-WILLI-SYNDROME; BEHAVIORAL
   PHENOTYPES; BIPOLAR DISORDER; UP-REGULATION; KANSL1 CAUSE; AUTISM;
   SCHIZOPHRENIA; MICE; 16P11.2
AB Gene expression can be modulated in two opposite directions, towards higher or lower amounts of product. How do diametric changes in gene dosage influence neurological development and function? Recent studies of transgenic and knockout mouse models, genomic copy-number variants, imprinted-gene expression alterations, and sex-chromosome aneuploidies are revealing examples of 'mirror-extreme' brain and behavior phenotypes, which provide unique insights into neurodevelopmental architecture. These convergent studies quantitatively connect gene dosages with specific trajectories and outcomes, with important implications for the experimental dissection of normal neurological functions, the genetic analysis of psychiatric disorders, the development of pharmacological therapies, and mechanisms for the evolution of human brain and behavior.
C1 Simon Fraser Univ, Dept Biol Sci, Burnaby, BC V5A 1S6, Canada.
RP Crespi, B (reprint author), Simon Fraser Univ, Dept Biol Sci, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada.
EM crespi@sfu.ca
FU Natural Sciences and Engineering Research Council of Canada
FX I am grateful to the Natural Sciences and Engineering Research Council
   of Canada for support.
CR Bath KG, 2012, BIOL PSYCHIAT
   Bi WM, 2007, HUM MOL GENET, V16, P1802, DOI 10.1093/hmg/ddm128
   Bianchin MM, 2011, NEUROLOGY, V76, P1772, DOI 10.1212/WNL.0b013e318219a086
   Boettger LM, 2012, NAT GENET
   Brunetti-Pierri N, 2008, NAT GENET, V40, P1466, DOI 10.1038/ng.279
   Buiting K, 2010, AM J MED GENET C, V154C, P365, DOI 10.1002/ajmg.c.30273
   Carmona-Mora P, 2010, CURR GENOMICS, V11, P607, DOI 10.2174/138920210793360952
   Chen M, 2012, ENDOCRINOLOGY
   Coe BP, 2012, AM J MED GENET C, V160C, P118, DOI 10.1002/ajmg.c.31327
   Collette JC, 2009, J HUM GENET, V54, P193, DOI 10.1038/jhg.2009.5
   Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
   Crespi B, 2012, J NEURODEV DIS
   Crespi B, 2010, P NATL ACAD SCI USA, V107, P1736, DOI 10.1073/pnas.0906080106
   Crespi B, 2011, P ROY SOC B-BIOL SCI, V278, P1441, DOI 10.1098/rspb.2010.2627
   Crespi B, 2008, BIOL REV, V83, P441, DOI 10.1111/j.1469-185X.2008.00050.x
   Crespi B, 2009, EVOL APPL, V2, P81, DOI 10.1111/j.1752-4571.2008.00056.x
   Dang VT, 2008, EUR J HUM GENET, V16, P1350, DOI 10.1038/ejhg.2008.111
   Doherty JL, 2012, CLIN GENET, V81, P103, DOI 10.1111/j.1399-0004.2011.01773.x
   Eggermann T, 2009, HORM RES, V71, P30, DOI 10.1159/000192433
   Fatemi SH, 2012, CEREBELLUM
   Gardiner K, 2012, AM J MED GENET A, V158A, P1388, DOI 10.1002/ajmg.a.35358
   Garelick MG, 2009, J NEUROSCI, V29, P10835, DOI 10.1523/JNEUROSCI.0553-09.2009
   Girirajan S, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002334
   Girirajan S, 2009, MAMM GENOME, V20, P247, DOI 10.1007/s00335-009-9180-y
   Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
   Grisart B, 2009, J MED GENET, V46, P524, DOI 10.1136/jmg.2008.065367
   Guedj F, 2012, NEUROBIOL DIS, V46, P190, DOI 10.1016/j.nbd.2012.01.007
   Harper KM, 2012, HUM MOL GENET
   Hasegawa S, 2009, MOL BRAIN, V2, DOI 10.1186/1756-6606-2-6
   Horev G, 2011, P NATL ACAD SCI USA, V108, P17076, DOI 10.1073/pnas.1114042108
   Huang N, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001154
   Jacobs SA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036387
   Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
   Jian XQ, 2011, J ABNORM CHILD PSYCH, V39, P773, DOI 10.1007/s10802-011-9524-4
   Kent L, 2008, AM J MED GENET B, V147B, P1295, DOI 10.1002/ajmg.b.30729
   Kitsiou-Tzeli S, 2012, GENE, V492, P319, DOI 10.1016/j.gene.2011.10.023
   Koolen DA, 2008, J MED GENET, V45, P710, DOI 10.1136/jmg.2008.058701
   Koolen DA, 2012, NAT GENET, V44, P639, DOI 10.1038/ng.2262
   Lacaria M, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002713
   Laje G, 2010, AM J MED GENET C, V154C, P456, DOI 10.1002/ajmg.c.30275
   Lee NR, 2011, INT REV RES DEV DISA, V40, P139, DOI 10.1016/B978-0-12-374478-4.00006-X
   Luo R, 2012, AM J HUM GENET
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
   Mefford HC, 2008, NEW ENGL J MED, V359, P1685, DOI 10.1056/NEJMoa0805384
   Mervis CB, 2012, AM J HUM GENET, V90, P1064, DOI 10.1016/j.ajhg.2012.04.012
   Mullaney R, 2009, DEV DISABIL RES REV, V15, P279, DOI 10.1002/ddrr.87
   Oegema R, 2010, MOL SYNDROMOL, V1, P113
   Papaleo F, 2011, LEARN MEMORY, V18, P534, DOI 10.1101/lm.2213711
   Papaleo F, 2008, J NEUROSCI, V28, P8709, DOI 10.1523/JNEUROSCI.2077-08.2008
   Peier AM, 2000, HUM MOL GENET, V9, P1145, DOI 10.1093/hmg/9.8.1145
   Pidsley R, 2012, EPIGENETICS-US, V7, P155, DOI 10.4161/epi.7.2.18910
   Ponting GP, 2006, BIOINFORMATICS, V22, P1031
   Potocki L, 2007, AM J HUM GENET, V80, P633, DOI 10.1086/512864
   Rimol LM, 2012, BIOL PSYCHIAT, V71, P552, DOI 10.1016/j.biopsych.2011.11.026
   Rio M, 2010, EUR J HUM GENET, V18, P285, DOI 10.1038/ejhg.2009.159
   Sakurai T, 2011, AUTISM RES, V4, P28, DOI 10.1002/aur.169
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sharkey FH, 2009, CYTOGENET GENOME RES, V127, P61, DOI 10.1159/000279260
   Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
   Sikela JM, 2006, PLOS GENET, V2, P646, DOI 10.1371/journal.pgen.0020080
   Sinnema M, 2011, RES DEV DISABIL, V32, P1729, DOI 10.1016/j.ridd.2011.02.027
   Steinberg KM, 2012, NAT GENET
   Suzuki A, 2011, J NEUROSCI, V31, P8786, DOI 10.1523/JNEUROSCI.3257-10.2011
   Teixeira CM, 2011, NEUROPSYCHOPHARMACOL, V36, P2395, DOI 10.1038/npp.2011.153
   Temple CM, 1996, CORTEX, V32, P335
   Vawter MP, 2007, AM J MED GENET B, V144B, P728, DOI 10.1002/ajmg.b.30454
   Wang CC, 2011, NEURON, V72, P789, DOI 10.1016/j.neuron.2011.09.023
   Weinstein LS, 2010, INT J OBESITY, V34, P6, DOI 10.1038/ijo.2009.222
   Willemsen MH, 2012, MOL SYNDROMOL, V2, P217
   Yabut O, 2010, J NEUROSCI, V30, P4004, DOI 10.1523/JNEUROSCI.4711-09.2010
   Zinn AR, 2007, BEHAV BRAIN FUNCT, V3, DOI 10.1186/1744-9081-3-24
   Zollino M, 2012, NAT GENET, V44, P636, DOI 10.1038/ng.2257
NR 73
TC 4
Z9 4
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0959-4388
J9 CURR OPIN NEUROBIOL
JI Curr. Opin. Neurobiol.
PD FEB
PY 2013
VL 23
IS 1
BP 143
EP 151
DI 10.1016/j.conb.2012.08.005
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 084TV
UT WOS:000314562900021
PM 22995549
ER

PT J
AU Abdallah, MW
   Larsen, N
   Grove, J
   Bonefeld-Jorgensen, EC
   Norgaard-Pedersen, B
   Hougaard, DM
   Mortensen, EL
AF Abdallah, Morsi W.
   Larsen, Nanna
   Grove, Jakob
   Bonefeld-Jorgensen, Eva C.
   Norgaard-Pedersen, Bent
   Hougaard, David M.
   Mortensen, Erik L.
TI Neonatal chemokine levels and risk of autism spectrum disorders:
   Findings from a Danish historic birth cohort follow-up study
SO CYTOKINE
LA English
DT Article
DE Autistic disorder; Chemokine; Newborn; Population Register; Dried blood
   spot
ID CYTOKINES; PREVALENCE; DIAGNOSIS; PLACENTA; REGISTER; DENMARK
AB A potential role of chemokines in the pathophysiology of Autism Spectrum Disorders (ASDs) has been previously suggested. In a recent study we examined levels of three inflammatory chemokines (MCP-1, MIP-1 alpha and RANTES) in samples of amniotic fluid of children diagnosed later in life with ASD and controls frequency-matched to cases on gender and year of birth. In this follow-up study, levels of the same chemokines were analyzed postnatally in dried blood spot samples from the same subjects utilizing the Danish Newborn Screening Biobank. Crude estimates showed decreased levels of RANTES. In the adjusted estimates, no differences were found in levels of the three examined chemokines in ASD cases compared to controls. Our findings may cautiously suggest an altered cell-mediated immunity during the early neonatal period in ASD. Further research is needed to examine the relationship between maternal/fetal and neonatal chemokine levels and their role in ASD. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Abdallah, Morsi W.] Aarhus Univ HLTH, Epidemiol Sect, DK-8000 Aarhus C, Denmark.
   [Abdallah, Morsi W.; Larsen, Nanna; Norgaard-Pedersen, Bent; Hougaard, David M.] Dept Clin Biochem, DK-2300 Copenhagen S, Denmark.
   [Abdallah, Morsi W.; Larsen, Nanna; Norgaard-Pedersen, Bent; Hougaard, David M.] Immunol Statens Serum Inst, DK-2300 Copenhagen S, Denmark.
   [Abdallah, Morsi W.] Univ Rostock, Dept Psychiat & Psychotherapy, Rostock Univ Hosp, D-18147 Rostock, Germany.
   [Grove, Jakob] Aarhus Univ HLTH, Dept Biomed, DK-8000 Aarhus C, Denmark.
   [Grove, Jakob] Bioinformat Res Ctr BiRC, DK-8000 Aarhus C, Denmark.
   [Bonefeld-Jorgensen, Eva C.] Aarhus Univ HLTH, Ctr Arct Environm Med, DK-8000 Aarhus C, Denmark.
   [Bonefeld-Jorgensen, Eva C.] Aarhus Univ HLTH, Unit Cellular & Mol Toxicol, DK-8000 Aarhus C, Denmark.
   [Mortensen, Erik L.] Univ Copenhagen, Inst Publ Hlth, DK-1014 Copenhagen K, Denmark.
   [Mortensen, Erik L.] Univ Copenhagen, Ctr Healthy Aging, DK-1014 Copenhagen K, Denmark.
RP Abdallah, MW (reprint author), Univ Rostock, Dept Psychiat & Psychotherapy, Rostock Univ Hosp, Gehlsheimer Str 20, D-18147 Rostock, Germany.
EM morsi.abdallah@med.uni-rostock.de; nla@ssi.dk; grove@humgen.au.dk;
   ebj@mil.au.dk; bnp@ssi.dk; dh@ssi.dk; elme@sund.ku.dk
RI Bonefeld-Jorgensen, Eva Cecilie/A-1682-2015
FU Danish Medical Research Foundation; Danish Ministry of the Interior and
   Health [271-05-0523/09-060179]; Aarhus University HEALTH, Aarhus,
   Denmark [494028]; Statens Serum Institute, Department of Clinical
   Biochemistry and Immunology, Copenhagen, Denmark [494028]
FX The authors thank Lasse S. Jonsson and Jorn Riis from Statens Serum
   Institute (SSI) and Maria Pryds for their assistance in data retrieval
   and also Vibeke Munk from University of Copenhagen for her
   administrative assistance. We also thank Dr. Poul Thorsen for his input
   and SSI Luminex Lab technical staff for their time and efforts. The
   Danish Historic Birth Cohort was established at Statens Serum Institute
   in Copenhagen with a grant from The Danish Medical Research Foundation
   and The Danish Ministry of the Interior and Health (Project No.
   271-05-0523/09-060179). This study is funded jointly by Aarhus
   University HEALTH, Aarhus, Denmark and Statens Serum Institute,
   Department of Clinical Biochemistry and Immunology, Copenhagen, Denmark
   (Project Title: Intrauterine Exposures and Childhood Psychiatric
   Disorders, Project ID: 494028).
CR Aaltonen R, 2005, OBSTET GYNECOL, V106, P802, DOI 10.1097/01.AOG.0000178750.84837.ed
   Abdallah MW, 2012, TURK J PSYCHIAT, P90
   Abdallah MW, 2012, BRAIN BEHAV IMMUN, V26, P170, DOI 10.1016/j.bbi.2011.09.003
   Abdallah MW, 2011, EUR CHILD ADOLES PSY, V20, P599, DOI 10.1007/s00787-011-0220-2
   Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Andersen TF, 1999, DAN MED BULL, V46, P263
   Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
   Ashwood P, 2010, BRAIN BEHAV IMMUN, V24, P898, DOI 10.1016/j.bbi.2010.01.008
   Atladottir HO, 2010, ARCH PEDIAT ADOL MED, V164, P470, DOI 10.1001/archpediatrics.2010.9
   Carlo WA, 2011, J PEDIATR-US, V159, P919, DOI 10.1016/j.jpeds.2011.05.042
   Comerford I, 2011, IMMUNOL CELL BIOL, V89, P183, DOI 10.1038/icb.2010.164
   Crawford A, 2011, PLOS PATHOG, V7, DOI 10.1371/journal.ppat.1002098
   Dammann O, 2008, CLIN PERINATOL, V35, P643, DOI 10.1016/j.clp.2008.07.011
   Deverman BE, 2009, NEURON, V64, P61, DOI 10.1016/j.neuron.2009.09.002
   Gillberg C, 2000, ACTA PSYCHIAT SCAND, V102, P321, DOI 10.1034/j.1600-0447.2000.102005321.x
   Gupta S, 1998, J NEUROIMMUNOL, V85, P106, DOI 10.1016/S0165-5728(98)00021-6
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Jon B, 2012, MMWR-MORBID MORTAL W, V61, P1
   Kim YS, 2011, AM J PSYCHIAT, V89, P90, DOI appi.ajp.2011.10101532
   Knudsen LB, 1998, DAN MED BULL, V45, P320
   Kugler KG, 2011, J CLIN BIOINFORMA, V1, P9, DOI DOI 10.1186/2043-9113-1-9
   Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
   Lauritsen MB, 2004, PSYCHOL MED, V34, P1339, DOI 10.1017/S0033291704002387
   Lauritsen MB, 2010, J AUTISM DEV DISORD, V40, P139, DOI 10.1007/s10803-009-0818-0
   Luminex Corporation, 2009, CYT CHEM GROWTH FACT
   Miles JH, 2011, GENET MED, V13, P278, DOI 10.1097/GIM.0b013e3181ff67ba
   MunkJorgensen P, 1997, DAN MED BULL, V44, P82
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   Norgaard-Pedersen B, 2007, J INHERIT METAB DIS, V30, P530, DOI 10.1007/s10545-007-0631-x
   Norgaard-Pedersen B, 1999, ACTA PAEDIATR, V88, P106, DOI 10.1080/08035259950170736
   Onore C., 2011, BRAIN BEHAV IMMUN, V26, P383
   Parner ET, 2008, ARCH PEDIAT ADOL MED, V162, P1150, DOI 10.1001/archpedi.162.12.1150
   Popp MW, 2011, P NATL ACAD SCI USA, V108, P3169, DOI 10.1073/pnas.1016863108
   Rajesh U, 2010, ARCH DIS CHILD-FETAL, V95, pFa65
   Rice C, 2007, MMWR
   Schmidt DR, 2006, ARCH DIS CHILD, V91, P661, DOI 10.1136/adc.2004.066514
   Skogstrand K, 2005, CLIN CHEM, V51, P1854, DOI 10.1373/clinchem.2005.052241
   SPSS Inc, 2009, IBM PASW STAT 18 SPS
   StataCorp LP, 2009, STAT STAT DAT AN
   Statens Serum Institut, 2010, NEON SCREEN BIOB PKU
   Suguitan AL, 2003, J INFECT DIS, V188, P1074
   Williams JG, 2006, ARCH DIS CHILD, V91, P8, DOI 10.1136/adc.2004.062083
   Zaretsky MV, 2004, OBSTET GYNECOL, V103, P546, DOI 10.1097/01.AOG.0000114980.40445.83
   Ziv Y, 2008, BRAIN BEHAV IMMUN, V22, P167, DOI 10.1016/j.bbi.2007.08.006
NR 44
TC 4
Z9 4
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
J9 CYTOKINE
JI Cytokine
PD FEB
PY 2013
VL 61
IS 2
BP 370
EP 376
DI 10.1016/j.cyto.2012.11.015
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA 087DZ
UT WOS:000314742800009
PM 23267761
ER

PT J
AU Laffargue, F
   Bourthoumieu, S
   Bellanne-Chantelot, C
   Guigonis, V
   Yardin, C
AF Laffargue, Fanny
   Bourthoumieu, Sylvie
   Bellanne-Chantelot, Christine
   Guigonis, Vincent
   Yardin, Catherine
TI Could FISH on buccal smears become a new method of screening in children
   suspect of HNF1B anomaly?
SO EUROPEAN JOURNAL OF MEDICAL GENETICS
LA English
DT Article
DE HNF1B deletion; Interphasic FISH; 17q12 microdeletion; Buccal smear
ID HYPERECHOGENIC KIDNEYS; GENOMIC REARRANGEMENTS; CHROMOSOME 17Q12;
   RENAL-DISEASE; TCF2 GENE; HEPATOCYTE; MUTATIONS; SPECTRUM; DELETION;
   AUTISM
AB HNF1B gene anomalies include renal development defects associated with cysts and are well known by pediatric nephrologists that ask for molecular analysis of this gene. Two types of genomic rearrangements are reported: mutation and more frequently deletion. Using microsatellites or CGH array the size of the deletion was found to be at least of 1.2 Mb including 15 genes among which HNF1B, leading to the diagnosis of chromosomal microdeletion. Fluorescent In Situ Hybridization (FISH) is a simple routinely performed technique, considered as the referring tool to diagnose microdeletion in genetic practice. We performed interphasic FISH on buccal smears from 6 patients known to have HNF1B deletion to valid our technique and to determine the size of the 17q12 deletion. All the patients were found to present a 17q12 microdeletion. Our results showed that FISH is a rapid, reliable and specific technique to diagnose 17q12 microdeletion and might be performed as non invasive sampling procedure useful in pediatric practice. In conclusion we propose to use interphasic FISH to screen pediatric patients presenting with renal abnormalities possibly linked to HNF1B anomaly. Molecular analysis and MLPA (Multiplex Ligand Probe Analysis) could be performed in cases with normal interphasic FISH to detect a point mutation of the gene or more rarely a single exon deletion. (C) 2013 Elsevier Masson SAS. All rights reserved.
C1 [Laffargue, Fanny; Bourthoumieu, Sylvie; Yardin, Catherine] Hop Univ Mere & Enfant HME, Dept Histol Cytol Cellular Biol & Cytogenet, F-87042 Limoges, France.
   [Bellanne-Chantelot, Christine] Univ Paris 06, Hop Pitie Salpetriere, AP HP, Dept Genet, Paris, France.
   [Laffargue, Fanny; Guigonis, Vincent] Hop Univ Mere & Enfant HME, Dept Pediat, Limoges, France.
   [Bourthoumieu, Sylvie; Guigonis, Vincent; Yardin, Catherine] CHU Dupuytren, CHREC Ctr Rech Clin HME, Limoges, France.
RP Yardin, C (reprint author), Hop Univ Mere & Enfant, Dept Histol Cytol Cellular Biol & Cytogenet, 8 Ave Dominique Larrey, F-87042 Limoges, France.
EM catherine.yardin@unilim.fr
CR Bellanne-Chantelot C, 2005, DIABETES, V54, P3126, DOI 10.2337/diabetes.54.11.3126
   Decramer S, 2007, J AM SOC NEPHROL, V18, P923, DOI 10.1681/ASN.2006091057
   Edghill EL, 2008, NEPHROL DIAL TRANSPL, V23, P627, DOI 10.1093/ndt/gfm603
   Faguer S., 2011, EUR J MED GENET, V54, P437
   Heidet L, 2010, CLIN J AM SOC NEPHRO, V5, P1079, DOI 10.2215/CJN.06810909
   Hodzic D, 2006, GENOMICS, V88, P731, DOI 10.1016/j.ygeno.2006.05.009
   Horikawa Y, 1997, NAT GENET, V17, P384, DOI 10.1038/ng1297-384
   Loirat C, 2010, NEPHROL DIAL TRANSPL, V25, P3430, DOI 10.1093/ndt/gfq380
   Mefford HC, 2007, AM J HUM GENET, V81, P1057, DOI 10.1086/522591
   Moreno-De-Luca D, 2010, AM J HUM GENET, V87, P618, DOI 10.1016/j.ajhg.2010.10.004
   Nagamani SCS, 2009, EUR J HUM GENET, V18, P278
   Nakayama M, 2010, PEDIATR NEPHROL, V25, P1073, DOI 10.1007/s00467-010-1454-9
   Raile K, 2009, J CLIN ENDOCR METAB, V94, P2658, DOI 10.1210/jc.2008-2189
   Shaffer LG, 2007, AM J MED GENET C, V145C, P335, DOI 10.1002/ajmg.c.30152
   Ulinski T, 2006, J AM SOC NEPHROL, V17, P497, DOI 10.1681/ASN.2005101040
NR 15
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1769-7212
J9 EUR J MED GENET
JI Eur. J. Med. Genet.
PD FEB
PY 2013
VL 56
IS 2
BP 93
EP 97
DI 10.1016/j.ejmg.2012.12.002
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA 085PY
UT WOS:000314627900005
PM 23261960
ER

PT J
AU Petersen, AK
   Ahmad, A
   Shafiq, M
   Brown-Kipphut, B
   Fong, CT
   Iqbal, MA
AF Petersen, Andrea Klunder
   Ahmad, Ausaf
   Shafiq, Mustafa
   Brown-Kipphut, Brigette
   Fong, Chin-To
   Iqbal, M. Anwar
TI Deletion 1q43 encompassing only CHRM3 in a patient with autistic
   disorder
SO EUROPEAN JOURNAL OF MEDICAL GENETICS
LA English
DT Article
DE 1q43 deletion; Acetylcholine receptor muscarinic 3; CHRM3; Autistic
   disorder; M3-muscarinic receptor; Microarray CGH
ID DEVELOPMENTAL DELAY; MENTAL-RETARDATION; CLEFT-PALATE; M3 RECEPTORS;
   TRANSMISSION; DEFECT; ARRAY; 15Q14; BOY
AB Deletions on the distal portion of the long arm of chromosome 1 result in complex and highly variable clinical phenotypes which include intellectual disability, autism, seizures, microcephaly/craniofacial dysmorphology, corpus callosal agenesis/hypogenesis, cardiac and genital anomalies, hand and foot abnormalities and short stature. Genotype-phenotype correlation reported a minimum region of 2 Mb at 1q43-q44. We report on a 3 1/2 year old male patient diagnosed with autistic disorder who has social withdrawal, eating problems, repetitive stereotypic behaviors including self-injurious head banging and hair pulling, and no seizures, anxiety, or mood swings. Array comparative genomic hybridization (aCGH) showed an interstitial deletion of 473 kb at 1q43 region (239,412,391-239,885,394; NCBI build37/hg19) harboring only CHRM3 (Acetylcholine Receptor, Muscarinic, 3; OMIM: 118494). Recently, another case with a de novo interstitial deletion of 911 kb at 1q43 encompassing three genes including CHRM3 was reported. The M3 muscarinic receptor influences a multitude of central and peripheral nervous system processes via its interaction with acetylcholine and may be an important modulator of behavior, learning and memory. We propose CHRM3 as a candidate gene responsible for our patient's specific phenotype as well as the overlapping phenotypic features of other patients with 1q43 or 1q43-q44 deletions. (C) 2013 Published by Elsevier Masson SAS.
C1 [Petersen, Andrea Klunder; Fong, Chin-To] Univ Rochester, Dept Pediat, Med Ctr, Rochester, NY 14642 USA.
   [Ahmad, Ausaf; Shafiq, Mustafa; Brown-Kipphut, Brigette; Iqbal, M. Anwar] Univ Rochester, Dept Pathol & Lab Med, Med Ctr, Rochester, NY 14642 USA.
RP Iqbal, MA (reprint author), Univ Rochester, Med Ctr, 601 Elmwood Ave,POB 608, Rochester, NY 14642 USA.
EM Anwar_Iqbal@urmc.rochester.edu
CR Ballif BC, 2012, HUM GENET, V131, P145, DOI 10.1007/s00439-011-1073-y
   Chen CP, 2008, EUR J MED GENET, V51, P368, DOI 10.1016/j.ejmg.2008.02.011
   Erdogan F, 2007, AM J MED GENET A, V143A, P172, DOI 10.1002/ajmg.a.31541
   Forsythe SM, 2002, AM J RESP CELL MOL, V26, P298
   Gentile M, 2003, AM J MED GENET A, V117A, P251, DOI 10.1002/ajmg.a.10018
   Grillner P, 1999, NEUROSCIENCE, V91, P557, DOI 10.1016/S0306-4522(98)00619-8
   Hathout EH, 1998, AM J MED GENET, V80, P396, DOI 10.1002/(SICI)1096-8628(19981204)80:4<396::AID-AJMG17>3.0.CO;2-#
   HSU KS, 1995, NEUROSCI LETT, V197, P141, DOI 10.1016/0304-3940(95)11915-J
   Perrone MD, 2012, EUR J MED GENET, V55, P117, DOI 10.1016/j.ejmg.2011.11.004
   PITLER TA, 1990, BRAIN RES, V534, P257, DOI 10.1016/0006-8993(90)90137-Z
   Poulin B, 2010, P NATL ACAD SCI USA, V107, P9440, DOI 10.1073/pnas.0914801107
   Shimojima K, 2012, J HUM GENET, V57, P593, DOI 10.1038/jhg.2012.77
NR 12
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1769-7212
J9 EUR J MED GENET
JI Eur. J. Med. Genet.
PD FEB
PY 2013
VL 56
IS 2
BP 118
EP 122
DI 10.1016/j.ejmg.2012.11.003
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA 085PY
UT WOS:000314627900009
PM 23253743
ER

PT J
AU Berryer, MH
   Hamdan, FF
   Klitten, LL
   Moller, RS
   Carmant, L
   Schwartzentruber, J
   Patry, L
   Dobrzeniecka, S
   Rochefort, D
   Neugnot-Cerioli, M
   Lacaille, JC
   Niu, ZY
   Eng, CM
   Yang, YP
   Palardy, S
   Belhumeur, C
   Rouleau, GA
   Tommerup, N
   Immken, L
   Beauchamp, MH
   Patel, GS
   Majewski, J
   Tarnopolsky, MA
   Scheffzek, K
   Hjalgrim, H
   Michaud, JL
   Di Cristo, G
AF Berryer, Martin H.
   Hamdan, Fadi F.
   Klitten, Laura L.
   Moller, Rikke S.
   Carmant, Lionel
   Schwartzentruber, Jeremy
   Patry, Lysanne
   Dobrzeniecka, Sylvia
   Rochefort, Daniel
   Neugnot-Cerioli, Mathilde
   Lacaille, Jean-Claude
   Niu, Zhiyv
   Eng, Christine M.
   Yang, Yaping
   Palardy, Sylvain
   Belhumeur, Celine
   Rouleau, Guy A.
   Tommerup, Niels
   Immken, LaDonna
   Beauchamp, Miriam H.
   Patel, Gayle Simpson
   Majewski, Jacek
   Tarnopolsky, Mark A.
   Scheffzek, Klaus
   Hjalgrim, Helle
   Michaud, Jacques L.
   Di Cristo, Graziella
TI Mutations in SYNGAP1 Cause Intellectual Disability, Autism, and a
   Specific Form of Epilepsy by Inducing Haploinsufficiency
SO HUMAN MUTATION
LA English
DT Article
DE SYNGAP1; haploinsufficiency; intellectual disability; autism; epilepsy
ID MENTAL-RETARDATION; NMDA RECEPTOR; VISUAL-CORTEX; COMPLEX; INNERVATION;
   DISORDERS; RASGAP; STATE
AB De novo mutations in SYNGAP1, which codes for a RAS/RAP GTP-activating protein, cause nonsyndromic intellectual disability (NSID). All disease-causing point mutations identified until now in SYNGAP1 are truncating, raising the possibility of an association between this type of mutations and NSID. Here, we report the identification of the first pathogenic missense mutations (c.1084T>C [p.W362R], c.1685C>T [p.P562L]) and three novel truncating mutations (c.283dupC [p.H95PfsX5], c.2212_2213del [p.S738X], and (c.2184del [p.N729TfsX31]) in SYNGAP1 in patients with NSID. A subset of these patients also showed ataxia, autism, and a specific form of generalized epilepsy that can be refractory to treatment. All of these mutations occurred de novo, except c.283dupC, which was inherited from a father who is a mosaic. Biolistic transfection of wild-type SYNGAP1 in pyramidal cells from cortical organotypic cultures significantly reduced activity-dependent phosphorylated extracellular signal-regulated kinase (pERK) levels. In contrast, constructs expressing p.W362R, p.P562L, or the previously described p.R579X had no significant effect on pERK levels. These experiments suggest that the de novo missense mutations, p.R579X, and possibly all the other truncating mutations in SYNGAP1 result in a loss of its function. Moreover, our study confirms the involvement of SYNGAP1 in autism while providing novel insight into the epileptic manifestations associated with its disruption.
C1 [Berryer, Martin H.; Hamdan, Fadi F.; Carmant, Lionel; Patry, Lysanne; Neugnot-Cerioli, Mathilde; Beauchamp, Miriam H.; Michaud, Jacques L.; Di Cristo, Graziella] Univ Montreal, Ctr Excellence Neurosci, Montreal, PQ, Canada.
   [Berryer, Martin H.; Hamdan, Fadi F.; Carmant, Lionel; Patry, Lysanne; Neugnot-Cerioli, Mathilde; Beauchamp, Miriam H.; Michaud, Jacques L.; Di Cristo, Graziella] St Justine Hosp Res Ctr, Montreal, PQ, Canada.
   [Klitten, Laura L.; Moller, Rikke S.; Hjalgrim, Helle] Danish Epilepsy Ctr, Dianalund, Denmark.
   [Klitten, Laura L.; Moller, Rikke S.; Tommerup, Niels] Univ Copenhagen, Wilhelm Johannsen Ctr Funct Genome Res, Copenhagen, Denmark.
   [Schwartzentruber, Jeremy; Majewski, Jacek] McGill Univ, Montreal, PQ, Canada.
   [Schwartzentruber, Jeremy; Majewski, Jacek] Genome Quebec Innovat Ctr, Montreal, PQ, Canada.
   [Dobrzeniecka, Sylvia; Rochefort, Daniel; Rouleau, Guy A.] Univ Montreal, Ctr Excellence Neurosci, Ctr Rech, Ctr Hosp Univ Montreal, Montreal, PQ, Canada.
   [Dobrzeniecka, Sylvia; Rochefort, Daniel; Rouleau, Guy A.] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada.
   [Lacaille, Jean-Claude] Univ Montreal, Dept Physiol, Grp Rech Syst Nerveux Cent, Montreal, PQ H3C 3J7, Canada.
   [Niu, Zhiyv; Eng, Christine M.; Yang, Yaping] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
   [Palardy, Sylvain] St Justine Hosp, Dept Psychiat, Montreal, PQ, Canada.
   [Belhumeur, Celine] St Justine Hosp, Dept Pediat, Montreal, PQ, Canada.
   [Immken, LaDonna; Patel, Gayle Simpson] Specially Children, Austin, TX USA.
   [Majewski, Jacek] McGill Univ, Dept Human Genet, Montreal, PQ, Canada.
   [Tarnopolsky, Mark A.] McMaster Univ, Hamilton, ON, Canada.
   [Tarnopolsky, Mark A.] McMaster Univ, Dept Med, Hamilton, ON, Canada.
   [Tarnopolsky, Mark A.] McMaster Univ, Dept Pediat, Hamilton, ON, Canada.
   [Scheffzek, Klaus] Med Univ Innsbruck, Bioctr, Div Biol Chem, A-6020 Innsbruck, Austria.
   [Hjalgrim, Helle] Univ So Denmark, Inst Reg Hlth Serv Res, Odense, Denmark.
RP Michaud, JL (reprint author), CHU St Justine Res Ctr, 3175 Cote St Catherine, Montreal, PQ H3T 1C5, Canada.
EM jacques.michaud@recherche-ste-justine.qc.ca
FU Canadian Institute of Health Research; Reseau de Medecine Genetique
   Appliquee; Scottish Rite Charitable Foundation; FORGE Canada; Fonds de
   Recherche en Sante du Quebec; Danish National Research Foundation;
   Lundbeck Foundation
FX Contract grant sponsors: Canadian Institute of Health Research; Reseau
   de Medecine Genetique Appliquee; Scottish Rite Charitable Foundation;
   FORGE Canada.J.L.M. holds a National Scientist Award from the Fonds de
   Recherche en Sante du Quebec. G.D.C. holds a Canada Research Chair. N.T.
   is supported by the Danish National Research Foundation and the Lundbeck
   Foundation. We thank Stefan Welti for assistance with Figure 2, and the
   patients and their parents for participating in this study. We are
   grateful to Dr. Nicole Leclerc for help with cell culture experiments
   and Dr. Myriam Srour for helpful discussions.
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
   Belsham DD, 2004, ENDOCRINOLOGY, V145, P393, DOI 10.1210/en.2003-0946
   Carlisle HJ, 2008, J NEUROSCI, V28, P13673, DOI 10.1523/JNEUROSCI.4695-08.2008
   Chattopadhyaya B, 2007, NEURON, V54, P889, DOI 10.1016/j.neuron.2007.05.015
   Chattopadhyaya B, 2004, J NEUROSCI, V24, P9598, DOI 10.1523/JNEUROSCI.1851-04.2004
   Emsley P, 2004, ACTA CRYSTALLOGR D, V60, P2126, DOI 10.1107/S0907444904019158
   Fenn TD, 2003, J APPL CRYSTALLOGR, V36, P944, DOI 10.1107/S0021889803006721
   Guo XC, 2009, NEUROPSYCHOPHARMACOL, V34, P1659, DOI 10.1038/npp.2008.223
   Hamdan FF, 2009, NEW ENGL J MED, V360, P599, DOI 10.1056/NEJMoa0805392
   Hamdan FF, 2011, AM J HUM GENET, V88, P306, DOI 10.1016/j.ajhg.2011.02.001
   Hamdan FF, 2011, BIOL PSYCHIAT, V69, P898, DOI 10.1016/j.biopsych.2010.11.015
   Kim JH, 1998, NEURON, V20, P683, DOI 10.1016/S0896-6273(00)81008-9
   Klitten LL, 2011, EPILEPSIA, V52, pE190, DOI 10.1111/j.1528-1167.2011.03304.x
   Komiyama NH, 2002, J NEUROSCI, V22, P9721
   Krapivinsky G, 2004, NEURON, V43, P563, DOI 10.1016/j.neuron.2004.08.003
   Krepischi ACV, 2010, AM J MED GENET A, V152A, P2376, DOI 10.1002/ajmg.a.33554
   Kumar P, 2009, NAT PROTOC, V4, P1073, DOI 10.1038/nprot.2009.86
   Li WD, 2001, J BIOL CHEM, V276, P21417, DOI 10.1074/jbc.M010744200
   Ligeti E, 2012, PHYSIOL REV, V92, P237, DOI 10.1152/physrev.00045.2010
   Muhia M, 2010, EUR J NEUROSCI, V31, P529, DOI 10.1111/j.1460-9568.2010.07079.x
   Opitz-Araya X, 2011, J VIS EXP, P2462
   Pena V, 2008, EMBO REP, V9, P350, DOI 10.1038/embor.2008.20
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Qin Y, 2005, GENE DEV, V19, P2000, DOI 10.1101/gad.342205
   Rumbaugh G, 2006, P NATL ACAD SCI USA, V103, P4344, DOI 10.1073/pnas.0600084103
   Scheffzek K, 1997, SCIENCE, V277, P333, DOI 10.1126/science.277.5324.333
   Schwarz JM, 2010, NAT METHODS, V7, P575, DOI 10.1038/nmeth0810-575
   Srour M, 2012, AM J HUM GENET, V90, P693, DOI 10.1016/j.ajhg.2012.02.011
   Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
   Zollino M, 2011, EUR J HUM GENET, V19, P239, DOI 10.1038/ejhg.2010.172
NR 30
TC 14
Z9 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1059-7794
J9 HUM MUTAT
JI Hum. Mutat.
PD FEB
PY 2013
VL 34
IS 2
BP 385
EP 394
DI 10.1002/humu.22248
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 083PP
UT WOS:000314477700016
PM 23161826
ER

PT J
AU Ota, T
   Iida, J
   Sawada, M
   Suehiro, Y
   Kishimoto, N
   Tanaka, S
   Nagauchi, K
   Nakanishi, Y
   Yamamuro, K
   Negoro, H
   Iwasaka, H
   Sadamatsu, M
   Kishimoto, T
AF Ota, Toyosaku
   Iida, Junzo
   Sawada, Masayuki
   Suehiro, Yuko
   Kishimoto, Naoko
   Tanaka, Shohei
   Nagauchi, Kiyoyuki
   Nakanishi, Yoko
   Yamamuro, Kazuhiko
   Negoro, Hideki
   Iwasaka, Hidemi
   Sadamatsu, Miyuki
   Kishimoto, Toshifumi
TI Comparison of pervasive developmental disorder and schizophrenia by the
   Japanese version of the National Adult Reading Test
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
LA English
DT Article
DE Japanese version of National Adult Reading Test; pervasive developmental
   disorder; schizophrenia; Wechsler Adult Intelligence Scale-Revised
ID ASPERGERS-SYNDROME; PSYCHOSIS; AUTISM
AB Objective. In adults, it is sometimes difficult to discriminate between pervasive developmental disorder (PDD) and schizophrenia (SCH) when positive symptoms are not outstanding. We examined whether the Japanese version of the National Adult Reading Test (JART), is a valid scale for evaluating pre-morbid intelligence quotient (IQ) in patients with SCH, and the Wechsler Adult Intelligence Scale-Revised (WAIS-R) are useful for helping to discriminate between PDD and SCH. Methods. Sixteen patients with adult PDD and 16 age-, education-and sex-matched patients with SCH participated in the present study. In addition, two groups were matched for JART and GAF scores. All subjects were scored on the JART and WAIS-R after informed consent on the aim of this study. Examiners who were blind to the diagnoses measured JART and WAIS-R. Results. Significant diagnosis-by-IQ examination interactions were found (F [1,30] = 10.049, P = 0.003). Furthermore, WAIS-R scores of the PDD group were higher than those of the SCH group (P = 0.002) considering two groups were matched for JART. Conclusions. The comparison of IQ in the PDD group and in the SCH group by JART and WAIS-R might be an easy and useful method for helping to discriminate between PDD and SCH.
C1 [Ota, Toyosaku; Sawada, Masayuki; Suehiro, Yuko; Kishimoto, Naoko; Tanaka, Shohei; Yamamuro, Kazuhiko; Sadamatsu, Miyuki; Kishimoto, Toshifumi] Nara Med Univ, Sch Med, Dept Psychiat, Nara, Japan.
   [Iida, Junzo] Nara Med Univ, Fac Nursing, Nara, Japan.
   [Nagauchi, Kiyoyuki; Nakanishi, Yoko] Tenri Hosp, Dept Psychiat, Nara, Japan.
   [Negoro, Hideki; Iwasaka, Hidemi] Nara Univ Educ, Nara, Japan.
RP Ota, T (reprint author), 840 Shijyou Cho, Kashihara, Nara 6348522, Japan.
EM toyosaku@naramed-u.ac.jp
FU Health and Labour Sciences Research Grants for Comprehensive Research on
   Disability Health and Welfare [22-04]
FX This work was supported by the Health and Labour Sciences Research
   Grants (22-04) for Comprehensive Research on Disability Health and
   Welfare.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bankier B, 1999, PSYCHOPATHOLOGY, V32, P43, DOI 10.1159/000029065
   CLEGHORN JM, 1990, SCHIZOPHR RES, V3, P211, DOI 10.1016/0920-9964(90)90038-9
   CRAWFORD JR, 1992, BRIT J PSYCHIAT, V161, P69, DOI 10.1192/bjp.161.1.69
   GOLDBERG TE, 1988, SCHIZOPHR RES, V1, P261, DOI 10.1016/0920-9964(88)90001-1
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Kurita H, 2005, PSYCHIAT CLIN NEUROS, V59, P490, DOI 10.1111/j.1440-1819.2005.01403.x
   Matsuoka K, 2006, PSYCHIAT CLIN NEUROS, V60, P332, DOI 10.1111/j.1440-1819.2006.01510.x
   Misawa G., 1993, JAPANESE WECHSLER AD
   National Language Research Institute, 1963, VOC CHIN CHAR 90 MAG
   Nelson H. E., 1982, NATL ADULT READING T
   Nelson HE, 1991, NATL ADULT READING T, V2nd
   NELSON HE, 1990, PSYCHOL MED, V20, P357
   OCARROLL R, 1992, SCHIZOPHR RES, V8, P137, DOI 10.1016/0920-9964(92)90030-9
   Raja M, 2001, GEN HOSP PSYCHIAT, V23, P285, DOI 10.1016/S0163-8343(01)00155-4
   RYAN RM, 1992, HOSP COMMUNITY PSYCH, V43, P807
   Shinagawa F., 1990, JAPANESE WECHSLER AD
   Spreen O, 1998, COMPENDIUM NEUROPSYC, P75
   Starling J, 2009, CURR PSYCHIAT REP, V11, P190
   Uetsuki M., 2006, SEISHIN IGAKU, V48, P15
   Wechsler D., 1981, MANUAL WECHSLER ADUL
NR 21
TC 3
Z9 3
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1365-1501
J9 INT J PSYCHIAT CLIN
JI Int. J. Psychiat. Clin.
PD FEB
PY 2013
VL 17
IS 1
BP 10
EP 15
DI 10.3109/13651501.2011.653380
PG 6
WC Psychiatry
SC Psychiatry
GA 084KB
UT WOS:000314536800003
PM 22335467
ER

PT J
AU Esterberg, ML
   Ousley, OY
   Cubells, JF
   Walker, EF
AF Esterberg, Michelle L.
   Ousley, Opal Y.
   Cubells, Joseph F.
   Walker, Elaine F.
TI Prodromal and Autistic Symptoms in Schizotypal Personality Disorder and
   22q11.2 Deletion Syndrome
SO JOURNAL OF ABNORMAL PSYCHOLOGY
LA English
DT Article
DE schizophrenia; autism; prodrome; 22q11DS; schizotypal
ID CARDIO-FACIAL SYNDROME; COPY-NUMBER VARIATIONS; SPECTRUM DISORDERS;
   VELOCARDIOFACIAL SYNDROME; PSYCHOTIC DISORDERS; YOUNG-ADULTS;
   RISK-FACTORS; SCHIZOPHRENIA; ADOLESCENTS; CHILDREN
AB Despite clear diagnostic distinctions, schizophrenia and autism share symptoms on several dimensions. Recent research has suggested the two disorders overlap in etiology, particularly with respect to inherited and noninherited genetic factors. Studying the relationship between psychotic-like and autistic-like symptoms in risk groups such as 22q11 deletion syndrome (22q11DS) and schizotypal personality disorder (SPD) has the potential to shed light on such etiologic factors; thus, the current study examined prodromal symptoms and autistic features in samples of 22q11DS and SPD subjects using standardized diagnostic measures, including the Structured Interview for Prodromal Symptoms (SIPS) and the Autism Diagnostic Inventory-Revised (ADI-R). Results showed that SPD subjects manifested significantly more severe childhood and current social as well as stereotypic autistic features, as well as more severe positive prodromal symptoms. The two groups did not differ on negative, disorganized, or general prodromal symptoms, but were distinguishable based on correlations between prodromal and autistic features; the relationships between childhood autistic features and current prodromal symptoms were stronger for the SPD group. The results suggest that childhood autistic features are less continuous with subsequent prodromal signs in 22q11DS patients relative to those with SPD, and the findings highlight the importance of studying the overlap in diagnostic phenomenology in groups at risk for developing psychosis and/or autism.
C1 [Esterberg, Michelle L.; Walker, Elaine F.] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA.
   [Ousley, Opal Y.; Cubells, Joseph F.] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA.
RP Esterberg, ML (reprint author), Emory Univ, Dept Psychol, 36 Eagle Row, Atlanta, GA 30322 USA.
EM mesterb@emory.edu
CR Amati F, 2007, GENE, V391, P91, DOI 10.1016/j.gene.2006.12.026
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Antshel KM, 2010, J AM ACAD CHILD PSY, V49, P333, DOI 10.1016/j.jaac.2010.01.010
   Antshel KM, 2006, J AM ACAD CHILD PSY, V45, P596, DOI 10.1097/01.chi.0000205703
   Antshel KM, 2007, J AUTISM DEV DISORD, V37, P1776, DOI 10.1007/s10803-006-0308-6
   Awadalla P, 2010, AM J HUM GENET, V87, P316, DOI 10.1016/j.ajhg.2010.07.019
   Baker KD, 2005, BRIT J PSYCHIAT, V186, P115, DOI 10.1192/bjp.186.2.115
   Barneveld PS, 2011, SCHIZOPHR RES, V126, P231, DOI 10.1016/j.schres.2010.09.004
   Bassett AS, 2003, AM J PSYCHIAT, V160, P1580, DOI 10.1176/appi.ajp.160.9.1580
   Bassett AS, 2010, AM J PSYCHIAT, V167, P899, DOI 10.1176/appi.ajp.2009.09071016
   BENDER L, 1947, AM J ORTHOPSYCHIAT, V17, P40
   Cannon TD, 2008, ARCH GEN PSYCHIAT, V65, P28, DOI 10.1001/archgenpsychiatry.2007.3
   Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
   Craddock N, 2006, MOL PSYCHIATR, V11, P446, DOI 10.1038/sj.mp.4001808
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
   Daniels JL, 2008, PEDIATRICS, V121, pE1357, DOI 10.1542/peds.2007-2296
   Debbane M, 2006, SCHIZOPHR RES, V84, P187, DOI 10.1016/j.schres.2006.01.019
   De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
   Esterberg ML, 2008, SCHIZOPHR RES, V104, P265, DOI 10.1016/j.schres.2008.04.029
   Girirajan S, 2010, HUM MOL GENET, V19, pR176, DOI 10.1093/hmg/ddq366
   Gothelf D, 2007, AM J PSYCHIAT, V164, P663, DOI 10.1176/appi.ajp.164.4.663
   Hurst RM, 2007, J AUTISM DEV DISORD, V37, P1711, DOI 10.1007/s10803-006-0302-z
   Ingason A, 2011, MOL PSYCHIATR, V16, P17, DOI 10.1038/mp.2009.101
   Jablensky A, 1997, SCHIZOPHR RES, V28, P111, DOI 10.1016/S0920-9964(97)85354-6
   Jolin EM, 2009, J AFFECT DISORDERS, V119, P177, DOI 10.1016/j.jad.2009.02.016
   Kates WR, 2011, BIOL PSYCHIAT, V69, P945, DOI 10.1016/j.biopsych.2010.10.027
   Kittler Jennifer E, 2007, Eat Behav, V8, P115, DOI 10.1016/j.eatbeh.2006.02.006
   Konstantareas MM, 2001, J AUTISM DEV DISORD, V31, P19, DOI 10.1023/A:1005605528309
   Kusenda M, 2008, CYTOGENET GENOME RES, V123, P36, DOI 10.1159/000184690
   Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
   Leung A, 2000, ACTA PSYCHIAT SCAND, V101, P3
   Lingam R, 2003, ARCH DIS CHILD, V88, P666, DOI 10.1136/adc.88.8.666
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   McGlashan TH, 2001, EARLY INTERVENTION P, P135
   Miller TJ, 2002, AM J PSYCHIAT, V159, P863, DOI 10.1176/appi.ajp.159.5.863
   Moreno-De-Luca D, 2011, CURR PSYCHIAT REP, V13, P129, DOI 10.1007/s11920-011-0183-5
   Murphy KC, 1999, ARCH GEN PSYCHIAT, V56, P940, DOI 10.1001/archpsyc.56.10.940
   Niklasson L, 2009, RES DEV DISABIL, V30, P763, DOI 10.1016/j.ridd.2008.10.007
   Niklasson L, 2010, RES DEV DISABIL, V31, P185, DOI 10.1016/j.ridd.2009.09.001
   Nylander L, 2001, ACTA PSYCHIAT SCAND, V103, P428, DOI 10.1034/j.1600-0447.2001.00175.x
   Pantelis C, 2003, AUST NZ J PSYCHIAT, V37, P399, DOI 10.1046/j.1440-1614.2003.01193.x
   Papolos DF, 1996, AM J PSYCHIAT, V153, P1541
   Pfohl B. M., 1997, STRUCTURED INTERVIEW, V1st
   Raine A, 2006, ANNU REV CLIN PSYCHO, V2, P291, DOI 10.1146/annurev.clinpsy.2.022305.095318
   Schaer M, 2009, SCHIZOPHR RES, V115, P182, DOI 10.1016/j.schres.2009.09.016
   Scott FJ, 2002, AUTISM, V6, P231, DOI 10.1177/1362361302006003002
   Shapiro DI, 2011, SCHIZOPHR RES, V129, P20, DOI 10.1016/j.schres.2011.03.030
   Shashi V, 2010, PSYCHIAT RES-NEUROIM, V181, P1, DOI 10.1016/j.pscychresns.2009.07.003
   Sheitman BB, 2004, SCHIZOPHR RES, V69, P119, DOI 10.1016/S0920-9964(03)00177-4
   Smieskova R, 2010, NEUROSCI BIOBEHAV R, V34, P1207, DOI 10.1016/j.neubiorev.2010.01.016
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Stoddard J, 2010, SCHIZOPHR RES, V118, P118, DOI 10.1016/j.schres.2009.12.011
   Tessner KD, 2011, SCHIZOPHRENIA BULL, V37, P432, DOI 10.1093/schbul/sbp087
   Thorup A, 2007, J NERV MENT DIS, V195, P396, DOI 10.1097/01.nmd.0000253784.59708.dd
   Vorstman JAS, 2006, J AM ACAD CHILD PSY, V45, P1104, DOI 10.1097/01.chi.0000228131.56956.cl
   Weiss MJ, 2001, BEHAV MODIF, V25, P785, DOI 10.1177/0145445501255007
   Wilson D. I., 1994, American Journal of Human Genetics, V55, pA169
   Yucel M, 2003, BRIT J PSYCHIAT, V182, P518, DOI 10.1192/bjp.182.6.518
NR 58
TC 3
Z9 3
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0021-843X
J9 J ABNORM PSYCHOL
JI J. Abnorm. Psychol.
PD FEB
PY 2013
VL 122
IS 1
BP 238
EP 249
DI 10.1037/a0028373
PG 12
WC Psychology, Clinical; Psychology, Multidisciplinary
SC Psychology
GA 085VD
UT WOS:000314641500027
PM 22686870
ER

PT J
AU Barbeau, EB
   Soulieres, I
   Dawson, M
   Zeffiro, TA
   Mottron, L
AF Barbeau, Elise B.
   Soulieres, Isabelle
   Dawson, Michelle
   Zeffiro, Thomas A.
   Mottron, Laurent
TI The Level and Nature of Autistic Intelligence III: Inspection Time
SO JOURNAL OF ABNORMAL PSYCHOLOGY
LA English
DT Article
DE autism; Asperger syndrome; perception; processing speed; Raven
   Progressive Matrices
ID CHILDREN; SPEED; DISORDER; SPECTRUM; INDIVIDUALS; PERFORMANCE;
   ABILITIES; SAVANT; FMRI; IQ
AB Across the autism spectrum, level of intelligence is highly dependent on the psychometric instrument used for assessment, and there are conflicting views concerning which measures best estimate autistic cognitive abilities. Inspection time is a processing speed measure associated with general intelligence in typical individuals. We therefore investigated autism spectrum performance on inspection time in relation to two different general intelligence tests. Autism spectrum individuals were divided into autistic and Asperger subgroups according to speech development history. Compared to a typical control group, mean inspection time for the autistic subgroup but not the Asperger subgroup was significantly shorter (by 31%). However, the shorter mean autistic inspection time was evident only when groups were matched on Wechsler IQ and disappeared when they were matched using Raven's Progressive Matrices. When autism spectrum abilities are compared to typical abilities, results may be influenced by speech development history as well as by the instrument used for intelligence matching.
C1 [Barbeau, Elise B.; Soulieres, Isabelle; Mottron, Laurent] Univ Montreal, Fernand Seguin Res Ctr, CET EDUM, Montreal, PQ, Canada.
   [Barbeau, Elise B.; Mottron, Laurent] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada.
   [Soulieres, Isabelle] Univ Montreal, Dept Psychol, Montreal, PQ H3C 3J7, Canada.
   [Zeffiro, Thomas A.] Massachusetts Gen Hosp, Neural Syst Grp, Boston, MA 02114 USA.
RP Mottron, L (reprint author), Hop Riviere Des Prairies, 7070 Blvd Perras, Montreal, PQ H1E 1A4, Canada.
EM mottronl@uniserve.com
CR Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI 10.1017/CBO9780511526770.002
   BARTAK L, 1975, BRIT J PSYCHIAT, V126, P127, DOI 10.1192/bjp.126.2.127
   Bolte S, 2009, J AUTISM DEV DISORD, V39, P678, DOI 10.1007/s10803-008-0667-2
   Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072
   CARPENTER PA, 1990, PSYCHOL REV, V97, P404, DOI 10.1037/0033-295X.97.3.404
   Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
   Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
   Deary IJ, 1996, J BIOSOC SCI, V28, P405
   Deary IJ, 2004, NEUROIMAGE, V22, P1466, DOI 10.1016/j.neuroimage.2004.03.047
   Grudnik JL, 2001, INTELLIGENCE, V29, P523, DOI 10.1016/S0160-2896(01)00078-2
   Hayashi M, 2008, BRAIN COGNITION, V66, P306, DOI 10.1016/j.bandc.2007.09.008
   Anderson M, 1998, INTELLIGENCE, V26, P383, DOI 10.1016/S0160-2896(99)00007-0
   Hill D, 2011, INTELLIGENCE, V39, P370, DOI 10.1016/j.intell.2011.06.005
   Kaldy Z, 2011, DEVELOPMENTAL SCI, V14, P980, DOI 10.1111/j.1467-7687.2011.01053.x
   KRANZLER JH, 1989, INTELLIGENCE, V13, P329, DOI 10.1016/S0160-2896(89)80006-6
   Leo Kanner, 1973, CHILDHOOD PSYCHOSIS
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luciano M, 2005, BIOL PSYCHOL, V70, P1, DOI 10.1016/j.biopsycho.2004.11.011
   Mackintosh N, 2011, IQ HUMAN INTELLIGENC
   Magiati I, 2001, AUTISM, V5, P399, DOI 10.1177/1362361301005004005
   Morsanyi K, 2010, DEVELOPMENTAL SCI, V13, P578, DOI 10.1111/j.1467-7687.2009.00915.x
   Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83
   Mottron L, 2007, DEV PSYCHOPATHOL, V19, P23, DOI 10.1017/S0954579407070022
   Neisser U., 1998, RISING CURVE LONG TE, DOI [10.1037/10270-000, DOI 10.1037/10270-000]
   NETTELBECK T, 1976, BRIT J PSYCHOL, V67, P17
   Nettelbeck T, 2001, INTELLIGENCE, V29, P459, DOI 10.1016/S0160-2896(01)00072-1
   Ozonoff S, 2008, AUTISM, V12, P457, DOI 10.1177/1362361308096402
   Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
   Pinheiro J, 2008, NLME LINEAR NONLINEA
   Plaisted K, 2011, PERS INDIV DIFFER, V51, P562, DOI 10.1016/j.paid.2011.05.005
   R Development Core Team, 2008, R LANG ENV STAT COMP
   Raven J. C., 1998, STANDARD PROGR MATRI
   Rutter M., 1966, EARLY CHILDHOOD AUTI, P51
   Scheuffgen K, 2000, DEV PSYCHOPATHOL, V12, P83, DOI 10.1017/S095457940000105X
   Sheppard LD, 2008, PERS INDIV DIFFER, V44, P535, DOI 10.1016/j.paid.2007.09.015
   Soulieres I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025372
   Soulieres I, 2009, HUM BRAIN MAPP, V30, P4082, DOI 10.1002/hbm.20831
   Waiter GD, 2008, NEUROIMAGE, V41, P581, DOI 10.1016/j.neuroimage.2008.02.045
   Wallace GL, 2009, J AUTISM DEV DISORD, V39, P809, DOI 10.1007/s10803-008-0684-1
   Wallace GL, 2009, PHILOS T R SOC B, V364, P1425, DOI 10.1098/rstb.2008.0330
   Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   YOUNG RL, 1995, J AUTISM DEV DISORD, V25, P231, DOI 10.1007/BF02179286
NR 44
TC 8
Z9 8
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0021-843X
J9 J ABNORM PSYCHOL
JI J. Abnorm. Psychol.
PD FEB
PY 2013
VL 122
IS 1
BP 295
EP 301
DI 10.1037/a0029984
PG 7
WC Psychology, Clinical; Psychology, Multidisciplinary
SC Psychology
GA 085VD
UT WOS:000314641500032
PM 23088375
ER

PT J
AU Yaghmaie, P
   Koudelka, CW
   Simpson, EL
AF Yaghmaie, Pouya
   Koudelka, Caroline W.
   Simpson, Eric L.
TI Mental health comorbidity in patients with atopic dermatitis
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Article
DE Atopic dermatitis; comorbidities; attention deficit hyperactivity
   disorder; anxiety; depression; autism; prevalence
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; POPULATION-BASED SAMPLE;
   QUALITY-OF-LIFE; PRESCHOOL-CHILDREN; UNITED-STATES; ECZEMA; ANXIETY;
   PREVALENCE; DISEASE; ASSOCIATIONS
AB Background: Recent data, primarily from Europe, suggest that children with atopic dermatitis (AD) might be at increased risk of mental health disorders.
   Objective: We aimed to quantify the mental health burden associated with pediatric AD in the United States.
   Methods: A cross-sectional study design was used analyzing data from the 2007 National Survey of Children's Health, a survey reporting on the health status of 92,642 noninstitutionalized children aged 0 to 17 years. The lifetime prevalence of various provider-diagnosed mental health conditions was calculated for those with and without a history of AD.
   Results: The odds of having attention deficit hyperactivity disorder was significantly increased in children with AD compared with the odds in control subjects without AD (odds ratio, 1.87; 95% CI, 1.54-2.27), even after controlling for known confounders. The adjusted odds ratios for depression, anxiety, conduct disorder, and autism were 1.81 (95% CI, 1.33-2.46), 1.77 (95% CI, 1.36-2.29), 1.87 (95% CI, 1.46-2.39), and 3.04 (95% CI, 2.13-4.34), respectively, and these estimates were all statistically significant. A clear dose-dependent relationship was observed between the prevalence of a mental health disorder and the reported severity of the skin disease.
   Conclusions: Our data reveal a striking association between mental health disorders and AD in the US pediatric population. The severity of the skin disease alters the strength of the association. Prospective cohort studies are needed to verify these associations and to explore underlying mechanisms. Strategies to prevent AD or to aggressively treat early skin inflammation might modify the risk of mental health disorders in at-risk children. (J Allergy Clin Immunol 2013;131:428-33.)
C1 [Yaghmaie, Pouya] Oregon Hlth & Sci Univ, Sch Med, Portland, OR 97239 USA.
   [Koudelka, Caroline W.] Oregon Hlth & Sci Univ, Oregon Clin & Translat Res Inst, Portland, OR 97239 USA.
   [Simpson, Eric L.] Oregon Hlth & Sci Univ, Dept Dermatol, Portland, OR 97239 USA.
RP Simpson, EL (reprint author), Oregon Hlth & Sci Univ, Dept Dermatol, Mail Code CH16D,3303 SW Bond Ave, Portland, OR 97239 USA.
EM simpsone@ohsu.edu
FU National Eczema Association; National Institute of Arthritis and
   Musculoskeletal and Skin Diseases at the National Institutes of Health
   [5K23AR057486]; OHSU School of Medicine Bacon Award; Oregon Clinical and
   Translational Research Institute (OCTRI) from the National Center for
   Research Resources (NCRR), a component of the National Institutes of
   Health (NIH) [5 KL2 RR024141-04]; NIH Roadmap for Medical Research;
   National Institutes of Health; Oregon Health and Science University
   School of Medicine Bacon Award; Oregon Clinical and Translational
   Research Institute; National Center for Research Resources
FX Supported by the National Eczema Association, a Mentored
   Patient-oriented Research Career Development Award from the National
   Institute of Arthritis and Musculoskeletal and Skin Diseases at the
   National Institutes of Health (5K23AR057486), and the OHSU School of
   Medicine Bacon Award. Support was also obtained from the Oregon Clinical
   and Translational Research Institute (OCTRI; grant no. 5 KL2
   RR024141-04) from the National Center for Research Resources (NCRR), a
   component of the National Institutes of Health (NIH), and the NIH
   Roadmap for Medical Research.E. L. Simpson has received grants from the
   National Eczema Association, the National Institutes of Health, the
   Oregon Health and Science University School of Medicine Bacon Award, the
   Oregon Clinical and Translational Research Institute, and the National
   Center for Research Resources and has consultant arrangements with
   Alcimed, Amgen, Asubio, Brickell Biotech, Celgen Corporation, Centocor,
   Clarion Healthcare, Galderma Laboratories, LEK Consulting, Medicis
   Pharmaceutical, Panmira Pharmaceuticals, Regeneron, and Versant
   Ventures. The rest of the authors declare that they have no relevant
   conflicts of interest.
CR Absolon CM, 1997, BRIT J DERMATOL, V137, P241, DOI 10.1046/j.1365-2133.1997.18121896.x
   Alexander F, 1950, PSYCHOSOMATIC MED
   Beattie PE, 2006, BRIT J DERMATOL, V155, P145, DOI 10.1111/j.1365-2133.2006.07185.x
   Ben-Gashir MA, 2004, BRIT J DERMATOL, V150, P284, DOI 10.1111/j.1365-2133.2004.05776.x
   Blackman JA, 2011, J PAEDIATR CHILD H, V47, P742, DOI 10.1111/j.1440-1754.2011.02044.x
   Carroll CL, 2005, PEDIATR DERMATOL, V22, P192, DOI 10.1111/j.1525-1470.2005.22303.x
   Chamlin SL, 2006, DERMATOL THER, V19, P104, DOI 10.1111/j.1529-8019.2006.00060.x
   Chamlin SL, 2004, PEDIATRICS, V114, P607, DOI 10.1542/peds.2004-0374
   DAUD LR, 1993, ARCH DIS CHILD, V69, P670
   Dieris-Hirche J, 2009, HAUTARZT, V60, P641, DOI 10.1007/s00105-009-1744-y
   Ellis CN, 2002, J AM ACAD DERMATOL, V46, P361, DOI 10.1067/mjd.2002.120528
   Hashizume H, 2006, CURR OPIN ALLERGY CL, V6, P335, DOI 10.1097/01.all.0000244793.03239.40
   Hashizume H, 2005, BRIT J DERMATOL, V152, P1161, DOI 10.1111/j.1365-2133.2005.06449.x
   Hiscock H, 2007, PEDIATRICS, V119, P86, DOI 10.1542/peds.2006-1757
   Kiecolt-Glaser JK, 2011, BRAIN BEHAV IMMUN, V25, P1725, DOI 10.1016/j.bbi.2011.07.229
   Kramer U, 1998, BRIT J DERMATOL, V139, P1040
   LAPIDUS CS, 1993, J AM ACAD DERMATOL, V28, P699
   Laughter D, 2000, J AM ACAD DERMATOL, V43, P649, DOI 10.1067/mjd.2000.107773
   Magalhaes ES, 2009, J NEUROIMMUNOL, V216, P108, DOI 10.1016/j.jneuroim.2009.09.015
   Merikangas KR, 1999, BIOL PSYCHIAT, V46, P1523, DOI 10.1016/S0006-3223(99)00172-9
   Mostafa G. A., 2008, Journal of Pediatric Neurology, V6, P115
   Odhiambo JA, 2009, J ALLERGY CLIN IMMUN, V124, P1251, DOI 10.1016/j.jaci.2009.10.009
   Pliszka SR, 2000, CHILD ADOL PSYCH CL, V9, P525
   Pollak Y, 2002, INT J NEUROPSYCHOPH, V5, P389, DOI 10.1017/S1461145702003152
   Reuveni H, 1999, ARCH PEDIAT ADOL MED, V153, P249
   Romanos M, 2010, J EPIDEMIOL COMMUN H, V64, P269, DOI 10.1136/jech.2009.093534
   Sacco R, 2010, AUTISM RES, V3, P237, DOI 10.1002/aur.151
   Schmitt J, 2009, JAMA-J AM MED ASSOC, V301, P724, DOI 10.1001/jama.2009.136
   Schmitt J, 2010, ALLERGY, V65, P1506, DOI 10.1111/j.1398-9995.2010.02449.x
   Shaw TE, 2011, J INVEST DERMATOL, V131, P67, DOI 10.1038/jid.2010.251
   Simpson EL, 2012, CURR DERMATOL REP, V1, P29
   Su JC, 1997, ARCH DIS CHILD, V76, P159
   Taurines Regina, 2010, Atten Defic Hyperact Disord, V2, P267, DOI 10.1007/s12402-010-0040-0
   Yang YW, 2010, ALLERGY, V65, P801, DOI 10.1111/j.1398-9995.2009.02249.x
   Yokomaku A, 2008, CHRONOBIOL INT, V25, P549, DOI 10.1080/07420520802261705
   Zimmerman AW, 2005, PEDIATR NEUROL, V33, P195, DOI 10.1016/j.pediatrneurol.2005.03.014
NR 36
TC 30
Z9 30
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD FEB
PY 2013
VL 131
IS 2
BP 428
EP 433
DI 10.1016/j.jaci.2012.10.041
PG 6
WC Allergy; Immunology
SC Allergy; Immunology
GA 086CT
UT WOS:000314661500021
PM 23245818
ER

PT J
AU Falcomata, TS
   Lang, R
AF Falcomata, Terry S.
   Lang, Russell
TI Introduction to the Special Issue: Challenging Behavior and Individuals
   with Developmental and Physical Disabilities
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Autism; Angelman syndrome; Challenging behavior; Choice; Feeding
   disorders; Functional communication training; Noncontinent
   reinforcement; Self-monitoring; Telehealth
AB The goal of the Journal of Physical and Developmental Disabilities' 2013 special issue is to highlight recent works in the assessment and treatment of challenging behavior in the area of developmental and physical disabilities. The special issue is comprised of literature reviews on as well as evaluations of novel approaches to the treatment of challenging behavior that utilize antecedent and consequence-based methods. Extensions of antecedent-based approaches are included in the areas of response blocking and fading; noncontingent reinforcement (NCR); and the incorporation of choice. Extensions of consequence-based approaches are included in the areas of functional communication training (FCT); and differential reinforcement (DRO) and self-monitoring.
C1 [Falcomata, Terry S.] Univ Texas Austin, Austin, TX 78712 USA.
   [Falcomata, Terry S.; Lang, Russell] Meadows Ctr Preventing Educ Risk, Austin, TX USA.
   [Lang, Russell] Texas State Univ, Austin, TX USA.
RP Falcomata, TS (reprint author), Univ Texas Austin, Dept Special Educ, 1 Univ Stn,D5300, Austin, TX 78712 USA.
EM falcomata@austin.utexas.edu
CR Demanche J, 2013, J DEV PHYS DISABIL, V25, P79, DOI 10.1007/s10882-012-9304-2
   DeRosa NM, 2013, J DEV PHYS DISABIL, V25, P119, DOI 10.1007/s10882-012-9312-2
   Doyle NM, 2013, J DEV PHYS DISABIL, V25, P91, DOI 10.1007/s10882-012-9305-1
   Falcomata TS, 2013, J DEV PHYS DISABIL, V25, P5, DOI 10.1007/s10882-012-9311-3
   Kadey HJ, 2013, J DEV PHYS DISABIL, V25, P343, DOI 10.1007/s10882-012-9313-1
   Lydon S., 2012, J DEV PHYS DISABILIT
   MacDonald A., 2012, J DEV PHYS DISABILIT
   Nuernberger JE, 2013, J DEV PHYS DISABIL, V25, P105, DOI 10.1007/s10882-012-9309-x
   Poppes P, 2010, RES DEV DISABIL, V31, P1269, DOI 10.1016/j.ridd.2010.07.017
   Radstaake M., 2012, J DEV PHYS DISABIL, DOI [10.1007/s10882-012-9302-4c, DOI 10.1007/S10882-012-9302-4C]
   Rispoli M, 2013, J DEV PHYS DISABIL, V25, P135, DOI 10.1007/s10882-012-9315-z
   Wacker DP, 2013, J DEV PHYS DISABIL, V25, P35, DOI 10.1007/s10882-012-9314-0
NR 12
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD FEB
PY 2013
VL 25
IS 1
SI SI
BP 1
EP 4
DI 10.1007/s10882-012-9328-7
PG 4
WC Rehabilitation
SC Rehabilitation
GA 084JC
UT WOS:000314534100001
ER

PT J
AU Falcomata, TS
   Wacker, DP
AF Falcomata, Terry S.
   Wacker, David P.
TI On the Use of Strategies for Programming Generalization During
   Functional Communication Training: A Review of the Literature
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Review
DE Functional communication training; Generalization
ID BEHAVIOR PROBLEMS; YOUNG-CHILDREN; AUTISM; SETTINGS; MAINTENANCE;
   ACQUISITION; EXTINCTION; PUNISHMENT
AB We conducted a review of the literature pertaining to Functional Communication Training (FCT) and the principles and tactics for programming generalization. Ten studies of FCT and generalization were identified, analyzed, and summarized using the framework provided by Stokes and Osnes (Behavior Therapist 20:337-355, 1989) that detailed principles and tactics programming generalization. In addition to the tactic of recruiting natural consequences which is inherent to FCT, several studies evaluated additional strategies for programming generalization during FCT including modification of maladaptive consequences, reinforcement of occurrences of generalization, training sufficient stimulus exemplars, programming common physical stimuli, and programming common social stimuli. The results of these studies suggest that a) FCT and the tactic of recruiting natural consequences is sometimes sufficient to produce generalization but not in every case, and b) generalization of the treatment effects of FCT can be enhanced through the use of specific tactics for programming generalization. Overall, the results of this review suggest that a relatively small number of studies of FCT have systematically evaluated generalization. Thus, future research should continue to evaluate specific strategies for programming generalization with FCT. This includes combining procedures such as recruiting natural consequences with other strategies outlined by Stokes and Osnes.
C1 [Falcomata, Terry S.] Univ Texas Austin, Austin, TX 78712 USA.
   [Falcomata, Terry S.] Meadows Ctr Preventing Educ Risk, Austin, TX USA.
   [Wacker, David P.] Univ Iowa, Iowa City, IA USA.
RP Falcomata, TS (reprint author), Univ Texas Austin, Austin, TX 78712 USA.
EM falcomata@austin.utexas.edu
CR Barretto A., 2007, J EARLY INTENSIVE BE, V<IT>3</IT>, P305
   BUZOLICH M J, 1991, AAC (Augmentative and Alternative Communication), V7, P88, DOI 10.1080/07434619112331275753
   Carr E. G., 1988, GEN MAINTENANCE LIFE, P221
   CARR EG, 1985, J APPL BEHAV ANAL, V18, P111, DOI 10.1901/jaba.1985.18-111
   Chambers M, 2003, RES DEV DISABIL, V24, P265, DOI 10.1016/S0891-4222(03)00042-8
   Conaghan B. P., 1992, J BEHAV ED, V2, P175
   Derby KM, 1997, J APPL BEHAV ANAL, V30, P507, DOI 10.1901/jaba.1997.30-507
   DURAND VM, 1992, J APPL BEHAV ANAL, V25, P777, DOI 10.1901/jaba.1992.25-777
   Durand VM, 1999, J APPL BEHAV ANAL, V32, P247, DOI 10.1901/jaba.1999.32-247
   DURAND VM, 1991, J APPL BEHAV ANAL, V24, P251, DOI 10.1901/jaba.1991.24-251
   Dyches T. T., 2002, AUGMENTATIVE ALTERNA, V18, P124, DOI 10.1080/07434610212331281211
   Falcomata TS, 2010, J APPL BEHAV ANAL, V43, P513, DOI 10.1901/jaba.2010.43-513
   FISHER W, 1993, J APPL BEHAV ANAL, V26, P23, DOI 10.1901/jaba.1993.26-23
   Franco JH, 2009, FOCUS AUTISM DEV DIS, V24, P146, DOI 10.1177/1088357609338380
   Hagopian LP, 1998, J APPL BEHAV ANAL, V31, P211, DOI 10.1901/jaba.1998.31-211
   HARCHIK AE, 1990, RES DEV DISABIL, V11, P77, DOI 10.1016/0891-4222(90)90006-T
   Horner RH, 2005, EXCEPT CHILDREN, V71, P165
   IWATA BA, 1982, ANAL INTERVEN DEVEL, V2, P3, DOI 10.1016/0270-4684(82)90003-9
   Kurtz PF, 2003, J APPL BEHAV ANAL, V36, P205, DOI 10.1901/jaba.2003.36-205
   Mash E. J., 2003, CHILD PSYCHOPATHOLOG
   Moes DR, 2002, J AUTISM DEV DISORD, V32, P519, DOI 10.1023/A:1021298729297
   NORTHUP J, 1991, J APPL BEHAV ANAL, V24, P509, DOI 10.1901/jaba.1991.24-509
   NORTHUP J, 1994, J APPL BEHAV ANAL, V27, P33, DOI 10.1901/jaba.1994.27-33
   O'Neill RE, 2001, J AUTISM DEV DISORD, V31, P235, DOI 10.1023/A:1010711518182
   Schindler HR, 2005, AM J MENT RETARD, V110, P36, DOI 10.1352/0895-8017(2005)110<36:GROPBO>2.0.CO;2
   STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
   STOKES TF, 1989, BEHAV THER, V20, P337, DOI 10.1016/S0005-7894(89)80054-1
   Tiger Jeffrey H, 2008, Behav Anal Pract, V1, P16
   Volkert VM, 2009, J APPL BEHAV ANAL, V42, P145, DOI 10.1901/jaba.2009.42-145
   WACKER D, 1990, J APPL BEHAV ANAL, V23, P333, DOI 10.1901/jaba.1990.23-333
   Wacker D. P., 2005, ED PSYCHOL, V25, P233, DOI [10. 1080/0144341042000301184, DOI 10.1080/0144341042000301184]
NR 31
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD FEB
PY 2013
VL 25
IS 1
SI SI
BP 5
EP 15
DI 10.1007/s10882-012-9311-3
PG 11
WC Rehabilitation
SC Rehabilitation
GA 084JC
UT WOS:000314534100002
ER

PT J
AU Wacker, DP
   Lee, JF
   Dalmau, YCP
   Kopelman, TG
   Lindgren, SD
   Kuhle, J
   Pelzel, KE
   Dyson, S
   Schieltz, KM
   Waldron, DB
AF Wacker, David P.
   Lee, John F.
   Dalmau, Yaniz C. Padilla
   Kopelman, Todd G.
   Lindgren, Scott D.
   Kuhle, Jennifer
   Pelzel, Kelly E.
   Dyson, Shannon
   Schieltz, Kelly M.
   Waldron, Debra B.
TI Conducting Functional Communication Training via Telehealth to Reduce
   the Problem Behavior of Young Children with Autism
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Functional communication training; Telehealth; Autism spectrum
   disorders; Problem behavior
ID LONG-TERM TREATMENT; ABERRANT BEHAVIOR
AB Functional communication training (FCT) was conducted by parents of 17 young children with autism spectrum disorders who displayed problem behavior. All procedures were conducted at regional clinics located an average of 15 miles from the families' homes. Parents received coaching via telehealth from behavior consultants who were located an average of 222 miles from the regional clinics. Parents first conducted functional analyses with telehealth consultation (Wacker, Lee et al. Journal of Applied Behavior Analysis, in press) and then conducted FCT that was matched to the identified function of problem behavior. Parent assistants located at the regional clinics received brief training in the procedures and supported the families during the clinic visits. FCT, conducted within a nonconcurrent multiple baseline design, reduced problem behavior by an average of 93.5 %. Results suggested that FCT can be conducted by parents via telehealth when experienced applied behavior analysts provide consultation.
C1 [Wacker, David P.; Kopelman, Todd G.; Lindgren, Scott D.; Waldron, Debra B.] Univ Iowa, Dept Pediat, Carver Coll Med, Childrens Hosp, Iowa City, IA 52242 USA.
   [Wacker, David P.; Lee, John F.; Dalmau, Yaniz C. Padilla; Kuhle, Jennifer; Pelzel, Kelly E.; Dyson, Shannon; Schieltz, Kelly M.] Univ Iowa, Ctr Disabil & Dev, Childrens Hosp, Iowa City, IA 52242 USA.
RP Wacker, DP (reprint author), Univ Iowa, Ctr Disabil & Dev, Childrens Hosp, 100 Hawkins Dr,Room 251, Iowa City, IA 52242 USA.
EM david-wacker@uiowa.edu
CR Asmus JM, 2004, J APPL BEHAV ANAL, V37, P283, DOI 10.1901/jaba.2004.37-283
   Barretto A., 2007, J EARLY INTENSIVE BE, V<IT>3</IT>, P305
   Barretto J., 2006, J APPL BEHAV ANAL, V39, P333
   Behavior Analysis Certification Board, 2012, CERT REG
   Bloom SE, 2011, J APPL BEHAV ANAL, V44, P19, DOI 10.1901/jaba.2011.44-19
   Call NA, 2009, J APPL BEHAV ANAL, V42, P723, DOI 10.1901/jaba.2009.42-723
   CARR EG, 1985, J APPL BEHAV ANAL, V18, P111, DOI 10.1901/jaba.1985.18-111
   Derby KM, 1997, J APPL BEHAV ANAL, V30, P507, DOI 10.1901/jaba.1997.30-507
   Durand V. M., 1985, SCH PSYCHOL REV, V14, P171
   Harding J. W., 2009, BEHAV ANAL PRACTICE, V2, P21
   Kurtz PF, 2003, J APPL BEHAV ANAL, V36, P205, DOI 10.1901/jaba.2003.36-205
   LALLI JS, 1995, J APPL BEHAV ANAL, V28, P261, DOI 10.1901/jaba.1995.28-261
   Pelios L, 1999, J APPL BEHAV ANAL, V32, P185, DOI 10.1901/jaba.1999.32-185
   Reimers T. M., 1988, BEHAVIORAL DISORDERS, V14, P7
   Rogers S., 2011, AUTISM SPECTRUM DISO, P1081
   Tiger Jeffrey H, 2008, Behav Anal Pract, V1, P16
   Volkert VM, 2009, J APPL BEHAV ANAL, V42, P145, DOI 10.1901/jaba.2009.42-145
   Wacker D. P., PSYCHOL REC IN PRESS
   Wacker D. P., 2005, ED PSYCHOL, V25, P233, DOI [10. 1080/0144341042000301184, DOI 10.1080/0144341042000301184]
   Wacker D. P., J APPL BEHA IN PRESS
   Wacker D. P., 2004, MAINTENANCE EFFECTS
   Wacker DP, 1998, J DEV BEHAV PEDIATR, V19, P260, DOI 10.1097/00004703-199808000-00004
   Wacker DP, 2011, J EXP ANAL BEHAV, V96, P261, DOI 10.1901/jeab.2011.96-261
NR 23
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD FEB
PY 2013
VL 25
IS 1
SI SI
BP 35
EP 48
DI 10.1007/s10882-012-9314-0
PG 14
WC Rehabilitation
SC Rehabilitation
GA 084JC
UT WOS:000314534100004
ER

PT J
AU Demanche, J
   Chok, JT
AF Demanche, John
   Chok, James T.
TI The Use of Wrist Weights and Vibratory Stimulation to Treat
   Self-Injurious Behavior
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Wrist weights; Matched and unmatched vibratory stimulation;
   Self-injurious behavior; Automatic reinforcement
ID SENSORY REINFORCEMENT; FUNCTIONAL-ANALYSIS; INTERVENTION
AB Identifying successful interventions for persistent and frequent self-injurious behavior maintained by automatic reinforcement can be very challenging. Two treatments that have shown some promise in isolation have been the use of wrist weights, and vibratory stimulation as an alternative means to achieve sensory reinforcement. The current study examined the effects of these interventions separately, and in combination, to address chronic self-injurious behavior in a child with autism and intellectual disability. Although wrist weights resulted in substantial decreases in self-injurious behavior, the combination of wrist weights and vibratory stimulation matching the hypothesized sensory consequences of self-injurious behavior resulted in further decreases. The use of vibratory stimulation that did not match the hypothesized sensory consequences of SIB was not effective at reducing SIB when it was presented alone or in combination with wrist weights.
C1 [Demanche, John; Chok, James T.] Melmark New England, Andover, MA 01810 USA.
RP Chok, JT (reprint author), Melmark New England, 461 River Rd, Andover, MA 01810 USA.
EM jchok@melmarkne.org
CR Hanley GP, 1998, J APPL BEHAV ANAL, V31, P307, DOI 10.1901/jaba.1998.31-307
   IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
   Meyerson L., 1970, PSYCHOLOGICAL ASPECT, V17, P133
   O'Reilly MF, 2003, BEHAV MODIF, V27, P538, DOI 10.1177/0145445503255573
   Piazza CC, 2000, J APPL BEHAV ANAL, V33, P13, DOI 10.1901/jaba.2000.33-13
   Sandler AG, 2001, J DEV PHYS DISABIL, V13, P307, DOI 10.1023/A:1016662404603
   VANHOUTEN R, 1993, J APPL BEHAV ANAL, V26, P197, DOI 10.1901/jaba.1993.26-197
   WELLS ME, 1983, AM J MENT DEF, V87, P664
NR 8
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD FEB
PY 2013
VL 25
IS 1
SI SI
BP 79
EP 90
DI 10.1007/s10882-012-9304-2
PG 12
WC Rehabilitation
SC Rehabilitation
GA 084JC
UT WOS:000314534100007
ER

PT J
AU Doyle, NM
   DeRosa, NM
   Roane, HS
AF Doyle, Niamh M.
   DeRosa, Nicole M.
   Roane, Henry S.
TI Development of a Combined Intervention to Decrease Problem Behavior
   Displayed by Siblings with Pervasive Developmental Disorder
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Parent training; Group contingency; Problem behavior
ID FUNCTIONAL-ANALYSIS; SELF-INJURY; CHILDREN; AUTISM; REINFORCEMENT;
   DISABILITIES; ADJUSTMENT; ATTENTION
AB Approximately 10-20 % of children with pervasive developmental disorder are likely to have a sibling with that disorder. Under such circumstances, caregivers may be faced with simultaneously implementing separate interventions for their children. Merging different treatments to decrease both children's problem behavior may permit for more fluid parent responses and increased procedural integrity. The current study describes one approach to treating problem behavior displayed by siblings with autism. Separate functional analyses identified a different maintaining reinforcer for each child's aggression. These behaviors were initially treated separately using functional communication training and delay fading. To ensure that the caregiver would be able to manage these siblings' behaviors concurrently, a protocol using differential reinforcement of other behaviors was implemented that was based on the separate functions of each child's behavior.
C1 [Doyle, Niamh M.; DeRosa, Nicole M.; Roane, Henry S.] SUNY Upstate Med Univ, Kelberman Ctr, Syracuse, NY 13202 USA.
   [Doyle, Niamh M.] SUNY Upstate Med Univ, Dept Pediat, Syracuse, NY 13202 USA.
RP Doyle, NM (reprint author), SUNY Upstate Med Univ, Dept Pediat, 600 E Genesee St,Suite 124, Syracuse, NY 13202 USA.
EM doylen@upstate.edu
CR Bachmeyer MH, 2009, J APPL BEHAV ANAL, V42, P641, DOI 10.1901/jaba.2009.42-641
   Ben Chaabane Delia B, 2009, J Appl Behav Anal, V42, P671, DOI 10.1901/jaba.2009.42-671
   Borrero CSW, 2006, J APPL BEHAV ANAL, V39, P375, DOI 10.1901/jaba.2006.170-04
   Call NA, 2005, J APPL BEHAV ANAL, V38, P385, DOI 10.1901/jaba.2005.51-04
   Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
   DAY HM, 1994, J APPL BEHAV ANAL, V27, P279, DOI 10.1901/jaba.1994.27-279
   Farley SE, 2005, J FAM PRACTICE, V54, P162
   Fischer SM, 1997, J APPL BEHAV ANAL, V30, P335, DOI 10.1901/jaba.1997.30-335
   FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
   Fisher WW, 1996, J APPL BEHAV ANAL, V29, P117, DOI 10.1901/jaba.1996.29-117
   Griffith GM, 2010, J AUTISM DEV DISORD, V40, P610, DOI 10.1007/s10803-009-0906-1
   Hanley GP, 2001, J APPL BEHAV ANAL, V34, P17, DOI 10.1901/jaba.2001.34-17
   Hanley GP, 1997, J APPL BEHAV ANAL, V30, P229, DOI 10.1901/jaba.1997.30-229
   Hastings RP, 2003, J AUTISM DEV DISORD, V33, P99, DOI 10.1023/A:1022290723442
   Ingvarsson ET, 2008, J APPL BEHAV ANAL, V41, P435, DOI 10.1901/jaba.2008.41-435
   IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
   Kamps D, 2011, J POSIT BEHAV INTERV, V13, P154, DOI 10.1177/1098300711398935
   KAZDIN AE, 1977, J APPL BEHAV ANAL, V10, P141, DOI 10.1901/jaba.1977.10-141
   Lalli JS, 1996, J APPL BEHAV ANAL, V29, P391, DOI 10.1901/jaba.1996.29-391
   Lerman DC, 2000, RES DEV DISABIL, V21, P183, DOI 10.1016/S0891-4222(00)00033-0
   Meadan H, 2009, TOP EARLY CHILD SPEC, V29, P90, DOI 10.1177/0271121409337950
   Moes DR, 2002, J AUTISM DEV DISORD, V32, P519, DOI 10.1023/A:1021298729297
   Pelham WE, 2008, J CLIN CHILD ADOLESC, V37, P184, DOI 10.1080/15374410701818681
   Petalas MA, 2009, AUTISM, V13, P471, DOI 10.1177/1362361309335721
   Phillips KJ, 2008, BEHAV INTERVENT, V23, P1, DOI 10.1002/bin.252
   Quintero N, 2010, FOCUS AUTISM DEV DIS, V25, P37, DOI 10.1177/1088357609350367
   Roane HS, 2004, J APPL BEHAV ANAL, V37, P213, DOI 10.1901/jaba.2004.37-213
   RODRIGUE JR, 1993, J AUTISM DEV DISORD, V23, P665, DOI 10.1007/BF01046108
   Ross P, 2006, J INTELLECT DEV DIS, V31, P77, DOI 10.1080/13668250600710864
   Smith MR, 1999, RES DEV DISABIL, V20, P183, DOI 10.1016/S0891-4222(99)00002-5
   SMITH RG, 1993, J APPL BEHAV ANAL, V26, P183, DOI 10.1901/jaba.1993.26-183
   Wallace MD, 2004, J APPL BEHAV ANAL, V37, P89, DOI 10.1901/jaba.2004.37-89
   Worsdell AS, 2000, J APPL BEHAV ANAL, V33, P167, DOI 10.1901/jaba.2000.33-167
NR 33
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD FEB
PY 2013
VL 25
IS 1
SI SI
BP 91
EP 104
DI 10.1007/s10882-012-9305-1
PG 14
WC Rehabilitation
SC Rehabilitation
GA 084JC
UT WOS:000314534100008
ER

PT J
AU Nuernberger, JE
   Vargo, KK
   Ringdahl, JE
AF Nuernberger, Jodi E.
   Vargo, Kristina K.
   Ringdahl, Joel E.
TI An Application of Differential Reinforcement of Other Behavior and
   Self-Monitoring to Address Repetitive Behavior
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Repetitive behavior; Challenging behavior; Autism; Differential
   reinforcement; Self-monitoring
ID INJURIOUS-BEHAVIOR; STEREOTYPY; DISABILITIES; AUTISM; DRO
AB Differential reinforcement of other behavior (DRO) and self-monitoring was used to reduce repetitive challenging behavior in the form of eyelash, eyebrow, and hair pulling exhibited by a 19-year-old woman with an autism spectrum disorder. Treatment evaluation included DRO with competing and non-competing stimuli in a private therapy room. Once the DRO interval exceeded 10 min, treatment was conducted in the participant's classroom. Results of the study suggested DRO was successful in both environments and across both stimulus types.
C1 [Nuernberger, Jodi E.; Vargo, Kristina K.; Ringdahl, Joel E.] So Illinois Univ, Inst Rehabil, Carbondale, IL 62901 USA.
RP Ringdahl, JE (reprint author), So Illinois Univ, Inst Rehabil, 1025 Lincoln Dr,Rehn Hall, Carbondale, IL 62901 USA.
EM joelringdahl@siu.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Centers for Disease Control and Prevention, 2012, MORBIDITY MORTALITY
   Chowdhury M, 2011, RES DEV DISABIL, V32, P383, DOI 10.1016/j.ridd.2010.11.015
   COWDERY GE, 1990, J APPL BEHAV ANAL, V23, P497, DOI 10.1901/jaba.1990.23-497
   FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
   Iwata Brian A, 2008, Behav Anal Pract, V1, P3
   IWATA BA, 1994, J APPL BEHAV ANAL, V27, P215, DOI 10.1901/jaba.1994.27-215
   IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
   Kliebert Megan L, 2011, Behav Anal Pract, V4, P17
   Matson J. L., 1995, QUESTIONS BEHAV FUNC
   Matson J. L., 2008, J DEV PHYS DISABIL, V20, P15
   Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
   Piazza CC, 1998, J APPL BEHAV ANAL, V31, P165, DOI 10.1901/jaba.1998.31-165
   Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
   Ringdahl JE, 1997, J APPL BEHAV ANAL, V30, P203, DOI 10.1901/jaba.1997.30-203
   Ringdahl JE, 2002, BEHAV INTERVENT, V17, P43, DOI 10.1002/bin.105
   Shabani DB, 2001, BEHAV INTERVENT, V16, P279, DOI 10.1002/bin.96.abs
   Shore BA, 1997, J APPL BEHAV ANAL, V30, P21, DOI 10.1901/jaba.1997.30-21
   Taylor BA, 2005, BEHAV INTERVENT, V20, P239, DOI 10.1002/bin.200
   Tiger JH, 2009, J APPL BEHAV ANAL, V42, P315, DOI 10.1901/jaba.2009.42-315
   VOLLMER TR, 1993, J APPL BEHAV ANAL, V26, P9, DOI 10.1901/jaba.1993.26-9
   Woods D. W., 2001, TIC DISORDERS TRICHO, P33
   Woods DW, 2002, BEHAV MODIF, V26, P315, DOI 10.1177/01445502026003001
NR 23
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD FEB
PY 2013
VL 25
IS 1
SI SI
BP 105
EP 117
DI 10.1007/s10882-012-9309-x
PG 13
WC Rehabilitation
SC Rehabilitation
GA 084JC
UT WOS:000314534100009
ER

PT J
AU Rispoli, M
   Ganz, J
   Neely, L
   Goodwyn, F
AF Rispoli, Mandy
   Ganz, Jennifer
   Neely, Leslie
   Goodwyn, Fara
TI The Effect of Noncontingent Positive Versus Negative Reinforcement on
   Multiply Controlled Behavior During Discrete Trial Training
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Challenging behavior; Discrete trial training; Multiple functions;
   Noncontingent reinforcement
ID DEVELOPMENTAL-DISABILITIES; FUNCTIONAL-ANALYSIS; ESCAPE; INTERVENTION;
   ABERRANT
AB Challenging behaviors with multiple functions are often difficult to treat as function-based treatments may interfere with one another. Noncontingent reinforcement may be one efficient and effective means of treating multiply controlled behavior. The purposes of this study were to compare the use of noncontingent tangible reinforcement (NCT) to noncontingent escape (NCE) with two young children with autism who engaged in multiply controlled challenging behavior. Second, we wished to examine the effect of NCT and NCE on compliance during discrete trial training. A reversal design with an embedded alternating treatment design was used to compare NCT and NCE. The NCT treatment resulted in greater reductions of challenging behavior than the NCE treatment for both participants. Compliance during discrete trial training increased under both NCT and NCE treatments.
C1 [Rispoli, Mandy; Ganz, Jennifer; Neely, Leslie; Goodwyn, Fara] Texas A&M Univ, College Stn, TX 77843 USA.
RP Rispoli, M (reprint author), Texas A&M Univ, College Stn, TX 77843 USA.
EM mrispoli@tamu.edu
CR Arick J. R., 2003, FOCUS AUTISM OTHER D, V18, P75, DOI [10.1177/108835760301800201, DOI 10.1177/108835760301800201]
   Beavers GA, 2011, J APPL BEHAV ANAL, V44, P593, DOI 10.1901/jaba.2011.44-593
   Bondy A. S., 1994, FOCUS AUTISTIC BEHAV, V9, P1, DOI DOI 10.1177/108835769400900301
   CARR EG, 1985, J APPL BEHAV ANAL, V18, P111, DOI 10.1901/jaba.1985.18-111
   Carr JE, 2000, RES DEV DISABIL, V21, P377, DOI 10.1016/S0891-4222(00)00050-0
   Cook CR, 2012, J SPEC EDUC, V46, P3, DOI 10.1177/0022466910369941
   DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
   DeLeon IG, 2001, J APPL BEHAV ANAL, V34, P521, DOI 10.1901/jaba.2001.34-521
   Fisher W. W., 2004, J APPL BEHAV ANAL, V37, P239, DOI 10.1901/jaba.2004.37-171
   Hanley GP, 1997, J APPL BEHAV ANAL, V30, P229, DOI 10.1901/jaba.1997.30-229
   Hanley GP, 2003, J APPL BEHAV ANAL, V36, P147, DOI 10.1901/jaba.2003.36-147
   Ingvarsson E. T., 2009, ED TREATMENT CHILDRE, V32, P371, DOI [DOI 10.1353/ETC.0.0064, 10.1353/etc.0.0064]
   Ingvarsson ET, 2008, J APPL BEHAV ANAL, V41, P435, DOI 10.1901/jaba.2008.41-435
   IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
   Kennedy C, 2005, SINGLE CASE DESIGNS
   Lalli JS, 1999, J APPL BEHAV ANAL, V32, P285, DOI 10.1901/jaba.1999.32-285
   Lomas JE, 2010, J APPL BEHAV ANAL, V43, P425, DOI 10.1901/jaba.2010.43-425
   Mildon RL, 2004, J POSIT BEHAV INTERV, V6, P92, DOI 10.1177/10983007040060020401
   Roane HS, 2001, J APPL BEHAV ANAL, V34, P333, DOI 10.1901/jaba.2001.34-333
   Schopler E., 2010, CHILDHOOD AUTISM RAT, VSecond
   Sugai G., 1999, BEHAV DISORDERS, V24, P223
   VOLLMER TR, 1995, J APPL BEHAV ANAL, V28, P15, DOI 10.1901/jaba.1995.28-15
   Wilder DA, 2001, RES DEV DISABIL, V22, P117, DOI 10.1016/S0891-4222(01)00061-0
NR 23
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD FEB
PY 2013
VL 25
IS 1
SI SI
BP 135
EP 148
DI 10.1007/s10882-012-9315-z
PG 14
WC Rehabilitation
SC Rehabilitation
GA 084JC
UT WOS:000314534100011
ER

PT J
AU Lydon, S
   Healy, O
   Dwyer, M
AF Lydon, Sinead
   Healy, Olive
   Dwyer, Martina
TI An Examination of Heart Rate During Challenging Behavior in Autism
   Spectrum Disorder
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Physiological arousal; Heart rate; Physiology; Autism spectrum disorder;
   Challenging behavior; Self-injurious behavior; Stereotypy; Behavior
   analysis; Psychophysiology
ID YOUNG-CHILDREN; FUNCTION QABF; AROUSAL; PSYCHOPHYSIOLOGY; INDIVIDUALS;
   STIMULATION; QUESTIONS; AGREEMENT; RESPONSES; TIME
AB Many researchers have proposed that challenging behaviors emitted by individuals with Autism Spectrum Disorder are related to abnormal physiological arousal. It has been suggested that behaviors such as stereotypy and self-injury function to regulate arousal and to reduce the discomfort associated with hypo- or hyper-arousal. Little empirical research has tested these theories. The current study investigated heart rate during challenging behavior in three children diagnosed with Autism Spectrum Disorder. Heart rate before, during, and after challenging behaviors was analysed. Specific heart rate patterns were found to co-occur with challenging behaviors. Abnormal heart rate responses to stressors were also noted. These findings offer little support for the arousal modulation theories of challenging behavior. We suggest that, for some individuals with Autism Spectrum Disorder, these behaviors serve to increase arousal and to allow, or sustain, access to a preferred state of heightened arousal. These findings, which are not wholly in line with previous research, may have implications for the assessment and treatment of challenging behavior.
C1 [Lydon, Sinead; Healy, Olive; Dwyer, Martina] Natl Univ Ireland Galway, Sch Psychol, Galway, Ireland.
RP Healy, O (reprint author), Natl Univ Ireland Galway, Sch Psychol, Univ Rd, Galway, Ireland.
EM olive.healy@nuigalway.ie
CR Barrera FJ, 2007, BEHAV INTERVENT, V22, P5, DOI 10.1002/bin.228
   Bolte S, 2008, J AUTISM DEV DISORD, V38, P776, DOI 10.1007/s10803-007-0443-8
   Brain KL, 1998, ARCH SUICIDE RES, V4, P227, DOI 10.1080/13811119808258298
   Chok JT, 2010, BEHAV INTERVENT, V25, P325, DOI 10.1002/bin.312
   COHEN J, 1960, EDUC PSYCHOL MEAS, V20, P37, DOI 10.1177/001316446002000104
   Delaney JPA, 2000, PERCEPT MOTOR SKILL, V91, P515, DOI 10.2466/PMS.91.6.515-524
   EDELSON SM, 1984, AM J MENT DEF, V89, P140
   Freeman RL, 1999, AM J MENT RETARD, V104, P330, DOI 10.1352/0895-8017(1999)104<0330:RBHRAP>2.0.CO;2
   GRAVELING RA, 1978, J AUTISM CHILD SCHIZ, V8, P441, DOI 10.1007/BF01538049
   Healy O, 2013, RES AUTISM SPECT DIS, V7, P66, DOI 10.1016/j.rasd.2012.05.006
   Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
   Hoch J., 2010, J APPL BIOBEHAVIORAL, V15, P119, DOI DOI 10.1111/J.1751-9861.2010.00056.X
   Hofmann S. G., 2006, FOCUS AUTISM OTHER D, V21, P100, DOI DOI 10.1177/10883576060210020101
   HUMPHREYS MS, 1984, PSYCHOL REV, V91, P153, DOI 10.1037/0033-295X.91.2.153
   HUTT C, 1964, NATURE, V204, P908, DOI 10.1038/204908a0
   HUTT C, 1975, ACTA PSYCHIAT SCAND, V51, P361, DOI 10.1111/j.1600-0447.1975.tb00014.x
   HUTT C, 1965, ANIM BEHAV, V13, P1, DOI 10.1016/0003-3472(65)90064-3
   Jansen LMC, 2006, J AUTISM DEV DISORD, V36, P891, DOI 10.1007/s10803-006-0124-z
   Kootz J. P., 1982, ARCH GEN PSYCHIAT, V38, P271, DOI [10.1007/BF01531308, DOI 10.1007/BF01531308]
   LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
   Lang R, 2010, RES AUTISM SPECT DIS, V4, P565, DOI 10.1016/j.rasd.2010.01.006
   Laukkanen RMT, 1998, J SPORT SCI, V16, pS3, DOI 10.1080/026404198366920
   Leekam SR, 2011, PSYCHOL BULL, V137, P562, DOI 10.1037/a0023341
   LEWIS M, 1984, AM J MENT DEF, V89, P287
   Lewis MH, 1998, MENT RETARD DEV D R, V4, P80, DOI 10.1002/(SICI)1098-2779(1998)4:2<80::AID-MRDD4>3.0.CO;2-0
   Mathews A. L., 1998, ANTECEDENT CONTROL I
   Matson J. L., 1995, QUESTIONS BEHAV FUNC
   Matson JL, 2012, RES DEV DISABIL, V33, P630, DOI 10.1016/j.ridd.2011.11.006
   Mayes LC, 2000, SEMIN PERINATOL, V24, P267, DOI 10.1053/sper.2000.9121
   MOLTNER A, 1990, PAIN, V43, P81, DOI 10.1016/0304-3959(90)90052-F
   Nesse R., 2000, ENCY STRESS, V2, P79
   PALATINI P, 2009, MEDICOGRAPHIA, V31, P414
   Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
   Romanczyk R. G., 1992, SELF INJURIOUS BEHAV, P93
   Schoen SA, 2008, RES AUTISM SPECT DIS, V2, P417, DOI 10.1016/j.rasd.2007.09.002
   Sigman M, 2003, AUTISM, V7, P205, DOI 10.1177/1362361303007002007
   SVEBAK S, 1980, BIOFEEDBACK SELF-REG, V5, P439, DOI 10.1007/BF01001359
   Terbizan D.J., 2009, MEASUREMENT PHYS ED, V6, P243, DOI DOI 10.1207/S15327841MPEE0604_3
   Toichi M, 2003, J AUTISM DEV DISORD, V33, P417, DOI 10.1023/A:1025062812374
   Willemsen-Swinkels SHN, 1998, J AUTISM DEV DISORD, V28, P547, DOI 10.1023/A:1026008313284
   Wolf S., 1979, BIOFEEDBACK PRINCIPL, P5
   Woodard CR, 2012, RES AUTISM SPECT DIS, V6, P1234, DOI 10.1016/j.rasd.2012.03.012
NR 42
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD FEB
PY 2013
VL 25
IS 1
SI SI
BP 149
EP 170
DI 10.1007/s10882-012-9324-y
PG 22
WC Rehabilitation
SC Rehabilitation
GA 084JC
UT WOS:000314534100012
ER

PT J
AU Weischenfeldt, J
   Symmons, O
   Spitz, F
   Korbel, JO
AF Weischenfeldt, Joachim
   Symmons, Orsolya
   Spitz, Francois
   Korbel, Jan O.
TI Phenotypic impact of genomic structural variation: insights from and for
   human disease
SO NATURE REVIEWS GENETICS
LA English
DT Review
ID COPY NUMBER VARIATION; THUMB-POLYSYNDACTYLY SYNDROME; AUTISM SPECTRUM
   DISORDERS; 22Q11.2 DELETION SYNDROME; DOWN-SYNDROME PHENOTYPES;
   PLURIPOTENT STEM-CELLS; SMITH-MAGENIS-SYNDROME; DE-NOVO CNVS;
   GENE-EXPRESSION; LONG-RANGE
AB Genomic structural variants have long been implicated in phenotypic diversity and human disease, but dissecting the mechanisms by which they exert their functional impact has proven elusive. Recently however, developments in high-throughput DNA sequencing and chromosomal engineering technology have facilitated the analysis of structural variants in human populations and model systems in unprecedented detail. In this Review, we describe how structural variants can affect molecular and cellular processes, leading to complex organismal phenotypes, including human disease. We further present advances in delineating disease-causing elements that are affected by structural variants, and we discuss future directions for research on the functional consequences of structural variants.
C1 [Weischenfeldt, Joachim; Korbel, Jan O.] European Mol Biol Lab, Genome Biol Unit, D-69117 Heidelberg, Germany.
   [Symmons, Orsolya; Spitz, Francois] European Mol Biol Lab, Dev Biol Unit, D-69117 Heidelberg, Germany.
RP Spitz, F (reprint author), European Mol Biol Lab, Genome Biol Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany.
EM spitz@embl.de; korbel@embl.de
RI sebastianovitsch, stepan/G-8507-2013; Korbel, Jan/G-6470-2012
OI Korbel, Jan/0000-0002-2798-3794
FU Emmy Noether Fellowship from the German Research Foundation (Deutsche
   Forschungsgemeinschaft); Louis-Jeantet Foundation
FX We thank R. Weatheritt for critical discussion of the manuscript. We
   apologize to all colleagues whose contributions could not be cited or
   highlighted owing to space limitations. J.O.K. was supported by an Emmy
   Noether Fellowship from the German Research Foundation (Deutsche
   Forschungsgemeinschaft). O.S. was supported by the Louis-Jeantet
   Foundation.
CR Abecasis GR, 2010, NATURE, V467, P1061, DOI DOI 10.1038/NATURE09534
   Abu-Issa R, 2002, DEVELOPMENT, V129, P4613
   Abyzov A, 2011, GENOME RES, V21, P974, DOI 10.1101/gr.114876.110
   Aggarwal VS, 2010, DEV BIOL, V344, P669, DOI 10.1016/j.ydbio.2010.05.496
   Agrelo R, 2010, SEMIN CELL DEV BIOL, V21, P194, DOI 10.1016/j.semcdb.2009.09.017
   Ahmed MM, 2012, J PROTEOME RES, V11, P1251, DOI 10.1021/pr2011582
   Albers CA, 2012, NAT GENET, V44, P435, DOI 10.1038/ng.1083
   Badano JL, 2006, NATURE, V439, P326, DOI 10.1038/nature04370
   Balaskas N, 2012, CELL, V148, P273, DOI 10.1016/j.cell.2011.10.047
   Bartolomei MS, 2011, CSH PERSPECT BIOL, V3, DOI 10.1101/cshperspect.a002592
   Belloni E, 1996, NAT GENET, V14, P353, DOI 10.1038/ng1196-353
   Benko S, 2009, NAT GENET, V41, P359, DOI 10.1038/ng.329
   Berglund J, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-8-r73
   Dunham I, 2012, NATURE, V489, P57, DOI 10.1038/nature11247
   Bisgaard AM, 2009, CLIN GENET, V75, P175, DOI 10.1111/j.1399-0004.2008.01113.x
   Brault V, 2006, PLOS GENET, V2, P911, DOI 10.1371/journal.pgen.0020086
   Brennand KJ, 2011, NATURE, V473, P221, DOI 10.1038/nature09915
   Brunetti-Pierri N, 2008, NAT GENET, V40, P1466, DOI 10.1038/ng.279
   Cahan P, 2009, NAT GENET, V41, P430, DOI 10.1038/ng.350
   Capdevila J, 2001, ANNU REV CELL DEV BI, V17, P87, DOI 10.1146/annurev.cellbio.17.1.87
   Chaignat E, 2011, GENOME RES, V21, P106, DOI 10.1101/gr.112748.110
   Chamberlain SJ, 2004, HUM MOL GENET, V13, P2971, DOI 10.1093/hmg/ddh314
   Cheung SW, 2005, GENET MED, V7, P422, DOI 10.1097/01.GIM.0000170992.63691.32
   Choi M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000395
   Conrad DF, 2010, NATURE, V464, P704, DOI 10.1038/nature08516
   Craddock N, 2010, NATURE, V464, P713, DOI 10.1038/nature08979
   Dang VT, 2008, EUR J HUM GENET, V16, P1350, DOI 10.1038/ejhg.2008.111
   Dathe K, 2009, AM J HUM GENET, V84, P483, DOI 10.1016/j.ajhg.2009.03.001
   de Cid R, 2009, NAT GENET, V41, P211, DOI 10.1038/ng.313
   DELACHAPELLE A, 1981, HUM GENET, V57, P253
   Delneri D, 2008, NAT GENET, V40, P113, DOI 10.1038/ng.2007.49
   de Mollerat XJ, 2003, HUM MOL GENET, V12, P1959, DOI 10.1093/hmg/ddg212
   Deutschbauer AM, 2005, GENETICS, V169, P1915, DOI 10.1534/genetics.104.036871
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Devoy A, 2012, NAT REV GENET, V13, P14, DOI 10.1038/nrg3116
   Eichler E. E, 2011, NATURE REV GENET, V12, P15
   Eichler EE, 2010, NAT REV GENET, V11, P446, DOI 10.1038/nrg2809
   ELIA J, 2012, NAT GENET, V44, P78, DOI DOI 10.1038/ng.1013
   Fanciulli M, 2007, NAT GENET, V39, P721, DOI 10.1038/ng2046
   Feuk L, 2006, NAT REV GENET, V7, P85, DOI 10.1038/nrg1767
   Firth HV, 2009, AM J HUM GENET, V84, P524, DOI 10.1016/j.ajhg.2009.03.010
   Friedli M, 2008, MAMM GENOME, V19, P272, DOI 10.1007/s00335-008-9106-0
   Ghazalpour A, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001393
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Girirajan S, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002334
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
   Gothelf D, 2005, NAT NEUROSCI, V8, P1500, DOI 10.1038/nn1572
   Greenway SC, 2009, NAT GENET, V41, P931, DOI 10.1038/ng.415
   Guo CS, 2011, J CLIN INVEST, V121, P1585, DOI 10.1172/JCI44630
   Guris DL, 2006, DEV CELL, V10, P81, DOI 10.1016/j.devcel.2005.12.002
   Handsaker RE, 2011, NAT GENET, V43, P269, DOI 10.1038/ng.768
   Hastings PJ, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000327
   Hastings PJ, 2009, NAT REV GENET, V10, P551, DOI 10.1038/nrg2593
   Henrichsen CN, 2009, NAT GENET, V41, P424, DOI 10.1038/ng.345
   Hodgkin J., 2005, WORMBOOK, P1
   Hollox EJ, 2008, NAT GENET, V40, P23, DOI 10.1038/ng.2007.48
   Hou YL, 2012, FUNCT INTEGR GENOMIC, V12, P81, DOI 10.1007/s10142-011-0252-1
   Hu TH, 2004, DEVELOPMENT, V131, P5491, DOI 10.1242/dev.01399
   Huang N, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001154
   Inoue K, 2002, ANNU REV GENOM HUM G, V3, P199, DOI 10.1146/annurev.genom.3.032802.120023
   Ivins S, 2005, DEV BIOL, V285, P554, DOI 10.1016/j.ydbio.2005.06.026
   Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
   Jaeger E, 2012, NAT GENET, V44, P699, DOI 10.1038/ng.2263
   Jones CA, 2011, BRIT J PHARMACOL, V164, P1162, DOI 10.1111/j.1476-5381.2011.01386.x
   Keane TM, 2011, NATURE, V477, P289, DOI 10.1038/nature10413
   Keller MP, 1999, SEMIN NEUROL, V19, P353, DOI 10.1055/s-2008-1040850
   KELLER SA, 1994, GENOMICS, V23, P309, DOI 10.1006/geno.1994.1506
   KIOUSSIS D, 1983, NATURE, V306, P662, DOI 10.1038/306662a0
   Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
   Kleinjan DA, 2005, AM J HUM GENET, V76, P8, DOI 10.1086/426833
   Kloosterman WP, 2012, CELL REP, V1, P648, DOI 10.1016/j.celrep.2012.05.009
   Klopocki E, 2007, AM J HUM GENET, V80, P232, DOI 10.1086/510919
   Klopocki E, 2011, AM J HUM GENET, V88, P70, DOI 10.1016/j.ajhg.2010.11.006
   Klopocki E, 2008, J MED GENET, V45, P370, DOI 10.1136/jmg.2007.055699
   Koolen DA, 2012, NAT GENET, V44, P639, DOI 10.1038/ng.2262
   Korbel JO, 2007, SCIENCE, V318, P420, DOI 10.1126/science.1149504
   Korbel JO, 2009, P NATL ACAD SCI USA, V106, P12031, DOI 10.1073/pnas.0813248106
   Kou Y, 2012, AM J MED GENET C, V160C, P130, DOI 10.1002/ajmg.c.31330
   Kurth I, 2009, NAT GENET, V41, P862, DOI 10.1038/ng0809-862
   Lana-Elola E, 2011, DIS MODEL MECH, V4, P586, DOI 10.1242/dmm.008078
   Lee C, 2010, EXPERT REV MOL MED, V12, DOI 10.1017/S1462399410001390
   Lee HJ, 2012, GENOME RES, V22, P539, DOI 10.1101/gr.129635.111
   Lee JA, 2007, CELL, V131, P1235, DOI 10.1016/j.cell.2007.11.037
   Lettice LA, 2012, DEV CELL, V22, P459, DOI 10.1016/j.devcel.2011.12.010
   Lettice LA, 2011, HUM MUTAT, V32, P1492, DOI 10.1002/humu.21615
   Liao J, 2008, DEV BIOL, V316, P524, DOI 10.1016/j.ydbio.2008.01.037
   Lieberman-Aiden E, 2009, SCIENCE, V326, P289, DOI 10.1126/science.1181369
   Lindsay EA, 2001, NATURE, V410, P97, DOI 10.1038/35065105
   LINDSLEY DL, 1972, GENETICS, V71, P157
   Liu PF, 2011, CELL, V146, P888, DOI 10.1016/j.cell.2011.07.042
   Lupski JR, 1998, TRENDS GENET, V14, P417, DOI 10.1016/S0168-9525(98)01555-8
   Lupski JR, 2007, NAT GENET, V39, pS43, DOI 10.1038/ng2084
   Lyle R, 2006, AM J MED GENET A, V140A, P1384, DOI 10.1002/ajmg.a.31247
   MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
   Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
   Maynard TM, 2002, INT J DEV NEUROSCI, V20, P407, DOI 10.1016/S0736-5748(02)00050-3
   McCarroll SA, 2009, NAT GENET, V41, P1341, DOI 10.1038/ng.490
   McCarroll SA, 2008, NAT GENET, V40, P1107, DOI 10.1038/ng.215
   Merla G, 2006, AM J HUM GENET, V79, P332, DOI 10.1086/506371
   Merscher S, 2001, CELL, V104, P619, DOI 10.1016/S0092-8674(01)00247-1
   Mills RE, 2011, NATURE, V470, P59, DOI 10.1038/nature09708
   Moon AM, 2006, DEV CELL, V10, P71, DOI 10.1016/j.devcel.2005.12.003
   Moy SS, 2008, MOL PSYCHIATR, V13, P4, DOI 10.1038/sj.mp.4002082
   Nobrega MA, 2004, NATURE, V431, P988, DOI 10.1038/nature03022
   O'Doherty A, 2005, SCIENCE, V309, P2033, DOI 10.1126/science.1114535
   Onishi-Seebacher M, 2011, BIOESSAYS, V33, P840, DOI 10.1002/bies.201100075
   Orozco LD, 2009, HUM MOL GENET, V18, P4118, DOI 10.1093/hmg/ddp360
   Pang AW, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-5-r52
   Park IH, 2008, CELL, V134, P877, DOI 10.1016/j.cell.2008.07.041
   Perry GH, 2007, NAT GENET, V39, P1256, DOI 10.1038/ng2123
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Potocki L, 2000, NAT GENET, V24, P84
   Rausch T, 2012, CELL, V148, P59, DOI 10.1016/j.cell.2011.12.013
   Ricard G, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000543
   Ruf S, 2011, NAT GENET, V43, P379, DOI 10.1038/ng.790
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Schlattl A, 2011, GENOME RES, V21, P2004, DOI 10.1101/gr.122614.111
   Schrimpf SP, 2009, PLOS BIOL, V7, P616, DOI 10.1371/journal.pbio.1000048
   Schwanhausser B, 2011, NATURE, V473, P337, DOI 10.1038/nature10098
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Shaffer LG, 2000, ANNU REV GENET, V34, P297, DOI 10.1146/annurev.genet.34.1.297
   Shaikh TH, 2000, HUM MOL GENET, V9, P489, DOI 10.1093/hmg/9.4.489
   Shaikh TH, 2011, HUM MOL GENET, V20, P880, DOI 10.1093/hmg/ddq527
   Sharp AJ, 2006, NAT GENET, V38, P1038, DOI 10.1038/ng1862
   Sidow A, 1999, NAT GENET, V23, P104, DOI 10.1038/12709
   Spitz F, 2003, CELL, V113, P405, DOI 10.1016/S0092-8674(03)00310-6
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Stenberg P, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000465
   Stephens PJ, 2011, CELL, V144, P27, DOI 10.1016/j.cell.2010.11.055
   Stranger BE, 2007, SCIENCE, V315, P848, DOI 10.1126/science.1136678
   Straub T, 2007, NAT REV GENET, V8, P47, DOI 10.1038/nrg2013
   Sudmant PH, 2010, SCIENCE, V330, P641, DOI 10.1126/science.1197005
   Sun M, 2008, J MED GENET, V45, P589, DOI 10.1136/jmg.2008.057646
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Turner DJ, 2008, NAT GENET, V40, P90, DOI 10.1038/ng.2007.40
   Urban AE, 2006, P NATL ACAD SCI USA, V103, P4534, DOI 10.1073/pnas.0511340103
   Vazquez-Mena O, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032667
   Vogel C, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.59
   Wallace HAC, 2007, CELL, V128, P197, DOI 10.1016/j.cell.2006.11.044
   Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
   Walz K, 2003, MOL CELL BIOL, V23, P3646, DOI 10.1128/MCB.23.10.3646-3655.2003
   Webber C, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000531
   Williams NM, 2010, LANCET, V376, P1401, DOI 10.1016/S0140-6736(10)61109-9
   Wu S, 2007, NAT GENET, V39, P922, DOI 10.1038/ng2060
   Yahya-Graison EA, 2007, AM J HUM GENET, V81, P475, DOI 10.1086/520000
   Yalcin B, 2011, NATURE, V477, P326, DOI 10.1038/nature10432
   Yan J, 2007, AM J HUM GENET, V80, P518, DOI 10.1086/512043
   Yan J, 2004, HUM MOL GENET, V13, P2613, DOI 10.1093/hmg/ddh288
   Zhang Z, 2008, HUM MOL GENET, V17, P150, DOI 10.1093/hmg/ddm291
   Zuk O, 2012, P NATL ACAD SCI USA, V109, P1193, DOI 10.1073/pnas.1119675109
NR 151
TC 42
Z9 43
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-0056
J9 NAT REV GENET
JI Nat. Rev. Genet.
PD FEB
PY 2013
VL 14
IS 2
BP 125
EP 138
DI 10.1038/nrg3373
PG 14
WC Genetics & Heredity
SC Genetics & Heredity
GA 085NR
UT WOS:000314622000012
PM 23329113
ER

PT J
AU Yates, D
AF Yates, Darran
TI NEURODEVELOPMENTAL DISORDERS Overproducing autism
SO NATURE REVIEWS NEUROSCIENCE
LA English
DT Editorial Material
NR 0
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-003X
J9 NAT REV NEUROSCI
JI Nat. Rev. Neurosci.
PD FEB
PY 2013
VL 14
IS 2
BP 79
EP 79
PG 1
WC Neurosciences
SC Neurosciences & Neurology
GA 084TY
UT WOS:000314563200004
PM 23324663
ER

PT J
AU van Harssel, JJT
   Weckhuysen, S
   van Kempen, MJA
   Hardies, K
   Verbeek, NE
   de Kovel, CGF
   Gunning, WB
   van Daalen, E
   de Jonge, MV
   Jansen, AC
   Vermeulen, RJ
   Arts, WFM
   Verhelst, H
   Fogarasi, A
   de Rijk-van Andel, JF
   Kelemen, A
   Lindhout, D
   De Jonghe, P
   Koeleman, BPC
   Suls, A
   Brilstra, EH
AF van Harssel, J. J. T.
   Weckhuysen, S.
   van Kempen, M. J. A.
   Hardies, K.
   Verbeek, N. E.
   de Kovel, C. G. F.
   Gunning, W. B.
   van Daalen, E.
   de Jonge, M. V.
   Jansen, A. C.
   Vermeulen, R. J.
   Arts, W. F. M.
   Verhelst, H.
   Fogarasi, A.
   de Rijk-van Andel, J. F.
   Kelemen, A.
   Lindhout, D.
   De Jonghe, P.
   Koeleman, B. P. C.
   Suls, A.
   Brilstra, E. H.
TI Clinical and genetic aspects of PCDH19-related epilepsy syndromes and
   the possible role of PCDH19 mutations in males with autism spectrum
   disorders
SO NEUROGENETICS
LA English
DT Article
DE PCDH19; Epilepsy; X-linked; Genetics; Autism spectrum disorder
ID SEVERE MYOCLONIC EPILEPSY; PROTOCADHERIN 19 MUTATIONS;
   MENTAL-RETARDATION; DRAVET-SYNDROME; DE-NOVO; CONVULSIVE DISORDER; SCN1A
   MUTATIONS; ONSET EPILEPSY; FAMILIAL FORM; FEMALES
AB Epilepsy and mental retardation limited to females (EFMR), caused by PCDH19 mutations, has a variable clinical expression that needs further exploration. Onset of epilepsy may be provoked by fever and can resemble Dravet syndrome. Furthermore, transmitting males have no seizures, but are reported to have rigid personalities suggesting possible autism spectrum disorders (ASD). Therefore, this study aimed to determine the phenotypic spectrum associated with PCDH19 mutations in Dravet-like and EFMR female patients and in males with ASD. We screened 120 females suffering from Dravet-like epilepsy, 136 females with EFMR features and 20 males with ASD. Phenotypes and genotypes of the PCDH19 mutation carriers were compared with those of 125 females with EFMR reported in the literature. We report 15 additional patients with a PCDH19 mutation. Review of clinical data of all reported patients showed that the clinical picture of EFMR is heterogeneous, but epilepsy onset in infancy, fever sensitivity and occurrence of seizures in clusters are key features. Seizures remit in the majority of patients during teenage years. Intellectual disability and behavioural disturbances are common. Fifty percent of all mutations are missense mutations, located in the extracellular domains only. Truncating mutations have been identified in all protein domains. One ASD proband carried one missense mutation predicted to have a deleterious effect, suggesting that ASD in males can be associated with PCDH19 mutations.
C1 [van Harssel, J. J. T.; van Kempen, M. J. A.; Verbeek, N. E.; de Kovel, C. G. F.; Lindhout, D.; Koeleman, B. P. C.; Brilstra, E. H.] Univ Med Ctr Utrecht, Dept Med Genet, NL-3508 AB Utrecht, Netherlands.
   [Weckhuysen, S.; Hardies, K.; De Jonghe, P.; Suls, A.] VIB, Dept Mol Genet, Neurogenet Grp, Antwerp, Belgium.
   [Weckhuysen, S.; Hardies, K.; De Jonghe, P.; Suls, A.] Univ Antwerp, Inst Born Bunge, Neurogenet Lab, B-2020 Antwerp, Belgium.
   [Weckhuysen, S.] Epilepsy Ctr Kempenhaeghe, Oosterhout, Netherlands.
   [Gunning, W. B.] Netherlands Fdn SEIN, Epilepsy Inst, Zwolle, Netherlands.
   [van Daalen, E.; de Jonge, M. V.] Univ Med Ctr Utrecht, Dept Child & Adolescent Psychiat, NL-3508 AB Utrecht, Netherlands.
   [Jansen, A. C.] UZ Brussel, Dept Pediat, Pediat Neurol Unit, Brussels, Belgium.
   [Jansen, A. C.] Vrije Univ Brussel, Dept Publ Hlth, Brussels, Belgium.
   [Vermeulen, R. J.] Vrije Univ Amsterdam Med Ctr, Dept Pediat Neurol, Amsterdam, Netherlands.
   [Arts, W. F. M.] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Neurol, Rotterdam, Netherlands.
   [Verhelst, H.] Ghent Univ Hosp, Div Pediat Neurol, Dept Pediat, Ghent, Belgium.
   [Fogarasi, A.] Bethesda Childrens Hosp, Epilepsy Ctr, Budapest, Hungary.
   [de Rijk-van Andel, J. F.] Amphia Hosp, Dept Neurol, Breda, Netherlands.
   [Kelemen, A.] Natl Inst Neurosci, Epilepsy Ctr, Budapest, Hungary.
   [Lindhout, D.] Netherlands Fdn, SEIN Epilepsy Inst, Hoofddorp, Netherlands.
   [De Jonghe, P.] Univ Antwerp Hosp, Div Neurol, Antwerp, Belgium.
RP Brilstra, EH (reprint author), Univ Med Ctr Utrecht, Dept Med Genet, POB 85090, NL-3508 AB Utrecht, Netherlands.
EM e.h.brilstra@umcutrecht.nl
RI Jansen, Anna/P-3121-2014
FU Flemish Government, University of Antwerp, the Interuniversity
   Attraction Poles program of the Belgian Science Policy Office [P6/43];
   Eurocores program EuroEPINOMICS of the European Science Foundation
FX We thank the patients and their family members for their cooperation and
   participation in this study. We also thank the VIB Genetic Service
   Facility (http://www.vibgeneticservicefacility.be) for the genetic
   analyses. The research is supported by the Fund for Scientific Research
   Flanders (FWO), Methusalem excellence grant of the Flemish Government,
   University of Antwerp, the Interuniversity Attraction Poles program
   P6/43 of the Belgian Science Policy Office, the Eurocores program
   EuroEPINOMICS of the European Science Foundation. A.S. is a postdoctoral
   fellow of the Fund for Scientific Research Flanders (FWO).
CR Camacho A, 2012, EPILEPSY BEHAV, V24, P134, DOI 10.1016/j.yebeh.2012.02.023
   Catarino CB, 2011, BRAIN, V134, P2982, DOI 10.1093/brain/awr129
   Claes L, 2003, HUM MUTAT, V21, P615, DOI 10.1002/humu.10217
   Depienne C, 2011, HUM MUTAT, V32, pE1959, DOI 10.1002/humu.21373
   Depienne C, 2012, HUM MUTAT, V33, P627, DOI 10.1002/humu.22029
   Depienne C, 2009, PLOS GENET, V2
   Dibbens LM, 2011, NEUROLOGY, V76, P1514, DOI 10.1212/WNL.0b013e318217e7b6
   Dibbens LM, 2008, NAT GENET, V40, P776, DOI 10.1038/ng.149
   Dimova PS, 2012, PEDIATR NEUROL, V46, P397, DOI 10.1016/j.pediatrneurol.2012.03.004
   FABISIAK K, 1990, CLIN GENET, V38, P353
   Genton P, 2011, EPILEPSIA, V52, P44, DOI 10.1111/j.1528-1167.2011.03001.x
   GRANTHAM R, 1974, SCIENCE, V185, P862, DOI 10.1126/science.185.4154.862
   Guerrini R, 1998, EPILEPSIA, V39, P508, DOI 10.1111/j.1528-1157.1998.tb01413.x
   Higurashi N, 2012, EPILEPSY RES, V99, P28, DOI 10.1016/j.eplepsyres.2011.10.014
   Hynes K, 2010, J MED GENET, V47, P211, DOI 10.1136/jmg.2009.068817
   Jamal SM, 2010, AM J MED GENET A, V152A, P2475, DOI 10.1002/ajmg.a.33611
   JUBERG RC, 1971, J PEDIATR-US, V79, P726, DOI 10.1016/S0022-3476(71)80382-7
   Kwong AKY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041802
   Lindhout D, 2008, BRAIN, V131, P900, DOI 10.1093/brain/awn056
   Marini C, 2010, NEUROLOGY, V75, P646, DOI 10.1212/WNL.0b013e3181ed9e67
   Marini C, 2012, EPILEPSIA, V53, P2111, DOI 10.1111/j.1528-1167.2012.03649.x
   Petrelli C, 2012, EPILEPSY RES, V99, P21, DOI 10.1016/j.eplepsyres.2011.10.010
   Piton A, 2011, MOL PSYCHIATR, V16, P867, DOI 10.1038/mp.2010.54
   Ryan SG, 1997, NAT GENET, V17, P92, DOI 10.1038/ng0997-92
   Scheffer IE, 2008, BRAIN, V131, P918, DOI 10.1093/brain/awm338
   Specchio N, 2011, EPILEPSIA, V52, P1251, DOI 10.1111/j.1528-1167.2011.03063.x
   Specchio N, 2011, EPILEPSIA, V52, pE172, DOI 10.1111/j.1528-1167.2011.03193.x
   Tarpey PS, 2009, NAT GENET, V41, P535, DOI 10.1038/ng.367
   Terracciano A, 2012, NEUROGENETICS, V13, P341, DOI 10.1007/s10048-012-0342-9
   Vincent A.K., 2011, CLIN GENET, V82, P540
   Wakai S, 1996, EUR J PEDIATR, V155, P724
   Wolff M, 2006, EPILEPSIA, V47, P45, DOI 10.1111/j.1528-1167.2006.00688.x
NR 32
TC 7
Z9 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1364-6745
J9 NEUROGENETICS
JI Neurogenetics
PD FEB
PY 2013
VL 14
IS 1
BP 23
EP 34
DI 10.1007/s10048-013-0353-1
PG 12
WC Genetics & Heredity; Clinical Neurology
SC Genetics & Heredity; Neurosciences & Neurology
GA 087LI
UT WOS:000314762500003
PM 23334464
ER

PT J
AU Hassanzadeh, L
   Erfani, M
   Najafi, R
   Shafiei, M
   Amini, M
   Shafiee, A
   Ebrahimi, SES
AF Hassanzadeh, Leila
   Erfani, Mostafa
   Najafi, Reza
   Shafiei, Mohammad
   Amini, Mohsen
   Shafiee, Abbass
   Ebrahimi, Seyed Esmaeil Sadat
TI Synthesis, radiolabeling and bioevaluation of a novel arylpiperazine
   derivative containing triazole as a 5-HT1A receptor imaging agents
SO NUCLEAR MEDICINE AND BIOLOGY
LA English
DT Article
DE 5-HT1A receptor; WAY100635; Tc-99m-tricarbonyl; Click chemistry
ID IN-VIVO; BIOMOLECULES; WAY-100635; BRAIN; RADIOLIGANDS; DESIGN; LIGAND;
   COMPLEXES; ANALOGS; METAL
AB Introduction: It has been recognized that serotonin plays a main role in various pathological conditions such as anxiety, depression, aggressiveness, schizophrenia, suicidal behavior, panic and autism. 1-(2-Methoxyphenyl) piperazine pharmacophore, a fragment of the true 5-HT1A antagonist WAY100635, is found in numerous selective 5-HT1A imaging agents. In this paper, we have reported the synthesis of a novel derivative of 1-(2-methoxyphenyl) piperazine that is labeled with Tc-99m (CO)(3) via click chemistry.
   Methods: The bidentate alkyne, propargylglycine was reacted with phenyl piperazine triazole derivative in the presence of a catalytic amount of Cu (I) to form tridentate ligand. The ligand was radiolabeled with the precursor [Tc-99m] [(H2O)(3) (CO)(3)](+) and characterized by HPLC. The bioevaluation of radio labeled ligand was carried out in rats.
   Results: Triazole complex was labeled by Tc-99m-tricarbonyl and its radiochemical yield was more than >95% which was determined by HPLC. In vivo stability studies in human serum albumin show a 93% ratio of complex after a 24 h period. The calculated partition coefficient (logP) was 0.34+/-0.02. Receptor binding assays indicated about 70% specific binding of radioligand to 5-HT1A receptors. Biodistribution studies have shown brain hippocampus uptake of 0.40+/-0.08 %ID/g at 30 min post injection.
   Conclusions: Results indicate that this Tc-99m-tricabonyl-arylpiperazine derivative has specific binding to 5-HT1A receptors and presented suitable characters for its use as a CNS imaging agent. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Hassanzadeh, Leila; Amini, Mohsen; Shafiee, Abbass; Ebrahimi, Seyed Esmaeil Sadat] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran.
   [Erfani, Mostafa; Najafi, Reza; Shafiei, Mohammad] Atom Energy Org Iran, Nucl Sci Res Sch, Nucl Sci & Technol Res Inst, Tehran, Iran.
RP Ebrahimi, SES (reprint author), Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran.
EM sesebrahimi@yahoo.com
CR Alberto R, 1998, J AM CHEM SOC, V120, P7987, DOI 10.1021/ja980745t
   Al Hussainy R, 2011, EUR J MED CHEM, V46, P5728, DOI 10.1016/j.ejmech.2011.06.023
   Al Hussainy R, 2011, J MED CHEM, V54, P3480, DOI 10.1021/jm1009956
   Benerjee SR, 2005, NUCL MED BIOL, V32, P1
   Chan TR, 2004, ORG LETT, V6, P2853, DOI 10.1021/ol0493094
   Chemel BR, 2006, PSYCHOPHARMACOLOGY, V188, P244, DOI 10.1007/s00213-006-0490-4
   Cliffe IA, 2000, NUCL MED BIOL, V27, P441, DOI 10.1016/S0969-8051(00)00109-8
   Fan WW, 2009, SCI CHINA SER B, V52, P590, DOI 10.1007/s11426-009-0054-7
   Ferrieri R. A., 2003, HDB RADIOPHARMACEUTI, P229
   Fletcher A., 1994, British Journal of Pharmacology, V112, p91P
   Halldin C, 2001, Q J NUCL MED, V45, P139
   Heimbold I, 2002, NUCL MED BIOL, V29, P375, DOI 10.1016/S0969-8051(01)00313-4
   Lang LX, 1999, J MED CHEM, V42, P1576, DOI 10.1021/jm980456f
   Lazarova N, 2005, INORG CHEM, V44, P6763, DOI 10.1021/ic050735a
   Leon A, 2002, NUCL MED BIOL, V29, P217, DOI 10.1016/S0969-8051(01)00295-5
   Madsen MT, 2007, J NUCL MED, V48, P661, DOI 10.2967/jnumed.106.032680
   Manish VD, 2010, NUCL MED BIOL, V37, P997
   Marion M B., 1976, ANAL BIOCHEM, V72, P248, DOI DOI 10.1016/0003-2697(76)90527-3
   Mindt TL, 2006, J AM CHEM SOC, V128, P15096, DOI 10.1021/ja066779f
   NEIRINCKX RD, 1987, J NUCL MED, V28, P191
   Pak JK, 2003, CHEM-EUR J, V9, P2053, DOI 10.1002/chem.200204445
   Papagiannopoulou D, 2002, NUCL MED BIOL, V29, P825, DOI 10.1016/S0969-8051(02)00343-8
   Passchier J, 2001, EUR J NUCL MED, V28, P113, DOI 10.1007/s002590000394
   Passchier J, 2000, NUCL MED BIOL, V27, P473, DOI 10.1016/S0969-8051(00)00114-1
   PEDIGO NW, 1981, J NEUROCHEM, V36, P220, DOI 10.1111/j.1471-4159.1981.tb02397.x
   Pike VW, 2001, PROGR MED CHEM, V38, P189, DOI 10.1016/S0079-6468(08)70094-8
   Pike VW, 2000, NUCL MED BIOL, V27, P449, DOI 10.1016/S0969-8051(00)00110-4
   Pike VW, 1994, MED CHEM RES, V5, P208
   Plenevaux A, 2000, J NEUROCHEM, V75, P803, DOI 10.1046/j.1471-4159.2000.0750803.x
   Saigal N, 2006, J NUCL MED, V47, P1697
   Schibli R, 2000, BIOCONJUGATE CHEM, V11, P345, DOI 10.1021/bc990127h
   Struthers H, 2008, CHEM-EUR J, V14, P6173, DOI 10.1002/chem.200702024
   VOLKERT WA, 1993, RADIOCHIM ACTA, V63, P205
   Zhang XZ, 2007, APPL RADIAT ISOTOPES, V65, P287, DOI 10.1016/j.apradiso.2006.09.001
   ZHUANG ZP, 1994, J MED CHEM, V37, P1406, DOI 10.1021/jm00036a003
NR 35
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0969-8051
J9 NUCL MED BIOL
JI Nucl. Med. Biol.
PD FEB
PY 2013
VL 40
IS 2
BP 227
EP 232
DI 10.1016/j.nucmedbio.2012.10.004
PG 6
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 085OY
UT WOS:000314625300011
PM 23141548
ER

PT J
AU Levenson, D
AF Levenson, Deborah
TI Might diet play a role in autism?
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Editorial Material
CR Beaudet AL, 2012, SCIENCE, V338, P342, DOI 10.1126/science.1229178
   Celestino-Soper PBS, 2012, P NATL ACAD SCI USA, V109, P7974, DOI 10.1073/pnas.1120210109
   Novarino G, 2012, SCIENCE, V338, P394, DOI 10.1126/science.1224631
   Sahin M, 2012, CURR OPIN NEUROBIOL, V22, P895, DOI 10.1016/j.conb.2012.04.008
NR 4
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD FEB
PY 2013
VL 161A
IS 2
BP VII
EP VIII
DI 10.1002/ajmg.a.35855
PG 2
WC Genetics & Heredity
SC Genetics & Heredity
GA 079DO
UT WOS:000314150600001
ER

PT J
AU Charman, T
   Gotham, K
AF Charman, Tony
   Gotham, Katherine
TI Measurement Issues: Screening and diagnostic instruments for autism
   spectrum disorders - lessons from research and practise
SO CHILD AND ADOLESCENT MENTAL HEALTH
LA English
DT Article
DE autism spectrum disorder (ASD); screening; diagnosis; sensitivity;
   specificity; predictive value
ID SOCIAL COMMUNICATION QUESTIONNAIRE; PERVASIVE DEVELOPMENTAL DISORDERS;
   IV-TR CLASSIFICATION; OBSERVATION SCHEDULE; ADI-R; MODIFIED CHECKLIST;
   POPULATION COHORT; ASPERGER-SYNDROME; CHILDHOOD-AUTISM; PARENTS CONCERNS
AB Background and Scope Significant progress has been made over the past two decades in the development of screening and diagnostic instruments for autism spectrum disorders (ASDs). This article reviews this progress, including recent innovations, focussing on those instruments for which the strongest research data on validity exists, and then addresses issues arising from their use in clinical settings. Findings Research studies have evaluated the ability of screens to prospectively identify cases of ASD in population-based and clinically referred samples, as well as the accuracy of diagnostic instruments to map onto gold standard clinical best estimate diagnosis. However, extension of the findings to clinical services must be done with caution, with a full understanding that instrument properties are sample-specific. Furthermore, we are limited by the lack of a true test for ASD which remains a behaviourally defined disorder. In addition, screening and diagnostic instruments help clinicians least in the cases where they are most in want of direction, as their accuracy will always be lower for marginal cases. Conclusion Instruments help clinicians to collect detailed, structured information and increase accuracy and reliability of referral for in-depth assessment and recommendations for support, but further research is needed to refine their effective use in clinical settings.
C1 [Charman, Tony; Gotham, Katherine] Kings Coll London, Inst Psychiat, London, England.
RP Charman, T (reprint author), Kings Coll London, Inst Psychiat, London, England.
RI Charman, Tony/A-2085-2014
OI Charman, Tony/0000-0003-1993-6549
FU COST Action [BM1004]; Clothworkers' Foundation; Pears Foundation; United
   States National Institute of Health [R01HD065277, R01 MH066469]; Autism
   Speaks Predoctoral Training Fellowship
FX The work of TC on screening is supported by the COST Action BM1004.
   Research at the Centre for Research in Autism and Education (CRAE) is
   supported by the Clothworkers' Foundation and Pears Foundation. The work
   of KG on diagnostic instruments has been supported by United States
   National Institute of Health grants R01HD065277 (PI: Somer Bishop), R01
   MH066469 (PI: Catherine Lord) and an Autism Speaks Predoctoral Training
   Fellowship.
CR Al-Qabandi M, 2011, PEDIATRICS, V128, pE211, DOI 10.1542/peds.2010-1881
   American Academy of Pediatrics, 2001, PEDIATRICS, V108, P192, DOI DOI 10.1542/PEDS.108.1.192
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
   BARONCOHEN S, 1992, BRIT J PSYCHIAT, V161, P839, DOI 10.1192/bjp.161.6.839
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Billstedt E, 2007, J CHILD PSYCHOL PSYC, V48, P1102, DOI 10.1111/j.1469-7610.2007.01774.x
   Bishop DVM, 1998, J CHILD PSYCHOL PSYC, V39, P879, DOI 10.1017/S0021963098002832
   Bolte S, 2008, J AM ACAD CHILD PSY, V47, P719, DOI 10.1097/CHI.0b013e31816c42bd
   Bolte S, 2008, AUTISM RES, V1, P354, DOI 10.1002/aur.49
   Canal-Bedia R, 2011, J AUTISM DEV DISORD, V41, P1342, DOI 10.1007/s10803-010-1163-z
   Center for Disease Control, 2009, MMWR-MORBID MORTAL W, V18, P1
   Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
   Charman T, 2007, BRIT J PSYCHIAT, V191, P554, DOI 10.1192/bjp.bp.107.040196
   Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022
   Cicchetti DV, 2008, J AUTISM DEV DISORD, V38, P764, DOI 10.1007/s10803-007-0448-3
   Clark A, 1999, J CHILD PSYCHOL PSYC, V40, P287, DOI 10.1017/S0021963098003400
   Constantino JN, 2007, J AM ACAD CHILD PSY, V46, P1668, DOI 10.1097/chi.0b013e318157cb23
   Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
   de Bildt A, 2009, J AUTISM DEV DISORD, V39, P1464, DOI 10.1007/s10803-009-0764-x
   de Bildt A, 2004, J AUTISM DEV DISORD, V34, P129
   de Bildt A, 2011, J AUTISM DEV DISORD, V41, P311, DOI 10.1007/s10803-010-1057-0
   Dereu M, 2010, J AUTISM DEV DISORD, V40, P1247, DOI 10.1007/s10803-010-0984-0
   Dietz C, 2006, J AUTISM DEV DISORD, V36, P713, DOI 10.1007/s10803-006-0114-1
   Eaves LC, 2006, J DEV BEHAV PEDIATR, V27, pS95, DOI 10.1097/00004703-200604002-00007
   Eaves LC, 2006, AUTISM, V10, P229, DOI 10.1177/1362361306063288
   Ehlers S, 1999, J AUTISM DEV DISORD, V29, P129, DOI 10.1023/A:1023040610384
   EHLERS S, 1993, J CHILD PSYCHOL PSYC, V34, P1327, DOI 10.1111/j.1469-7610.1993.tb02094.x
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Gillberg C., 2000, AUTISM, V4, P11, DOI 10.1177/1362361300004001002
   Glascoe FP, 1997, PEDIATRICS, V99, P522, DOI 10.1542/peds.99.4.522
   Glascoe FP, 1999, J PAEDIATR CHILD H, V35, P1, DOI 10.1046/j.1440-1754.1999.00342.x
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P400, DOI DOI 10.1007/S10803-006-0280-1
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2011, AUTISM SPECTRUM DISO, P30
   Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
   Gray KM, 2008, J AUTISM DEV DISORD, V38, P657, DOI 10.1007/s10803-007-0432-y
   Hus V., ADOS ADAPTED M UNPUB
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Kim SH, 2012, J AUTISM DEV DISORD, V42, P82, DOI 10.1007/s10803-011-1213-1
   Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
   Leekam SR, 2002, J CHILD PSYCHOL PSYC, V43, P327, DOI 10.1111/1469-7610.00024
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C., 1993, INFANT MENT HEALTH J, V14, P1234
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
   Luyster R, 2009, J AUTISM DEV DISORD, V39, P1305, DOI 10.1007/s10803-009-0746-z
   Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
   Manning SE, 2011, PEDIATRICS, V127, P1043, DOI 10.1542/peds.2010-2943
   Molloy CA, 2011, AUTISM, V15, P143, DOI 10.1177/1362361310379241
   Nordin V, 1998, ACTA PSYCHIAT SCAND, V97, P99, DOI 10.1111/j.1600-0447.1998.tb09970.x
   Norris M, 2010, AUTISM, V14, P263, DOI 10.1177/1362361309348071
   Nygren G, 2009, J AUTISM DEV DISORD, V39, P730, DOI 10.1007/s10803-008-0678-z
   Oosterling I, 2010, J CHILD PSYCHOL PSYC, V51, P1260, DOI 10.1111/j.1469-7610.2010.02246.x
   Oosterling I, 2010, J AUTISM DEV DISORD, V40, P689, DOI 10.1007/s10803-009-0915-0
   Oosterling IJ, 2009, J AUTISM DEV DISORD, V39, P897, DOI 10.1007/s10803-009-0692-9
   Oosterling IJ, 2010, J CHILD PSYCHOL PSYC, V51, P250, DOI 10.1111/j.1469-7610.2009.02150.x
   Posserud MB, 2009, J AUTISM DEV DISORD, V39, P126, DOI 10.1007/s10803-008-0609-z
   Posserud MB, 2006, J CHILD PSYCHOL PSYC, V47, P167, DOI 10.1111/j.1469-7610.2005.01462.x
   Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Robins DL, 2008, AUTISM, V12, P537, DOI 10.1177/1362361308094502
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rutter M., 2003, SOCIAL COMMUNICATION
   Santosh PJ, 2009, EUR CHILD ADOLES PSY, V18, P521, DOI 10.1007/s00787-009-0004-0
   Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008
   Wetherby AM, 2008, AUTISM, V12, P487, DOI 10.1177/1362361308094501
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
   Willemsen-Swinkels S. H. N., 2006, J AUTISM DEV DISORD, V36, P723
   Williams J, 2005, AUTISM, V9, P45, DOI 10.1177/136261305049029
   Williams JG, 2008, J AUTISM DEV DISORD, V38, P1731, DOI 10.1007/s10803-008-0558-6
   Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
   World Health Organization, 1993, MENT DIS GLOSS GUID
NR 79
TC 14
Z9 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-357X
J9 CHILD ADOL MENT H-UK
JI Child Adolesc. Ment. Health
PD FEB
PY 2013
VL 18
IS 1
BP 52
EP 63
DI 10.1111/j.1475-3588.2012.00664.x
PG 12
WC Psychology, Clinical; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 076TN
UT WOS:000313981000008
ER

PT J
AU Moricke, E
   Lappenschaar, GAM
   Swinkels, SHN
   Rommelse, NNJ
   Buitelaar, JK
AF Moricke, Esme
   Lappenschaar, G. A. Martijn
   Swinkels, Sophie H. N.
   Rommelse, Nanda N. J.
   Buitelaar, Jan K.
TI Latent class analysis reveals five homogeneous behavioural and
   developmental profiles in a large Dutch population sample of infants
   aged 14-15 months
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Exploratory factor analysis; Latent class analysis; Behavioural and
   developmental profiles and problems; Infants; General population
ID AUTISM SPECTRUM DISORDERS; TRAITS QUESTIONNAIRE ESAT;
   PRESCHOOL-CHILDREN; EARLY-CHILDHOOD; PSYCHOPATHOLOGY; CLASSIFICATION;
   RELIABILITY; PREDICTORS; PATHWAYS; LANGUAGE
AB Precursors of child psychiatric disorders are often present in infancy, but little is known about the prevalence and course of general psychopathology in population-based samples of children 0-3 years. We examined whether homogeneous behavioural and developmental profiles could be identified in children aged 14-15 months (M = 14.84; SD = 2.19), and we explored whether or not these profiles corresponded with existing classifications of DSM-IV-TR, ICD-10, and DC 0-3R. Parents of 6,330 children answered 74 items about externalizing, internalizing, and social-communicative behaviour. Exploratory factor analysis revealed nine factors: deviant communication, negative emotionality, deviant reactive behaviour, deviant play behaviour, demanding behaviour, social anxiety/inhibition, advanced social interaction problems, basic social interaction problems, and sleep problems. Latent class analysis yielded five profiles, of which three were associated with increased behavioural and developmental problems. Some infants (5.7 %) had communication and social interaction problems corresponding to multisystem developmental disorders (DC 0-3R) and suggestive of anxiety, mood, or pervasive developmental disorders (DSM-IV-TR, ICD-10). Other infants (16.4 %) had communication problems, possibly precursors of communication, language, or speech disorders (DSM-IV-TR, ICD-10). Yet other infants (10.8 %) showed negative and demanding behaviour suggestive of regulation disorders (DC 0-3R), attention-deficit and disruptive behaviour disorders (DSM-IV-TR), or hyperkinetic and conduct disorders (ICD-10). Thus, even in infancy certain distinct behavioural and developmental profiles can be recognized. This combined approach will enable follow-up research into the stability of factors, classes, and profiles over time, and will facilitate early detection, diagnosis, and treatment of behavioural and developmental problems.
C1 [Moricke, Esme; Lappenschaar, G. A. Martijn; Swinkels, Sophie H. N.; Rommelse, Nanda N. J.] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat 966, Nijmegen Ctr Evidence Based Practice, NL-6500 HB Nijmegen, Netherlands.
   [Rommelse, Nanda N. J.; Buitelaar, Jan K.] Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands.
   [Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands.
RP Moricke, E (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Psychiat 966, Nijmegen Ctr Evidence Based Practice, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM e.moricke@psy.umcn.nl
RI Rommelse, Nanda/D-4872-2009
OI Rommelse, Nanda/0000-0002-1711-0359
FU Dutch Organization for Scientific Research [ZonMw CZ-TT 940-38-045];
   University Medical Centre Utrecht, The Netherlands; Radboud University
   Nijmegen Medical Centre, The Netherlands; Karakter University Centre
   Nijmegen, The Netherlands
FX This research is part of the SOSO project, which is financially
   supported by the Dutch Organization for Scientific Research (ZonMw CZ-TT
   940-38-045 Research Program Chronic Diseases) and by University Medical
   Centre Utrecht, Radboud University Nijmegen Medical Centre, and Karakter
   University Centre Nijmegen, The Netherlands. We are very grateful to the
   parents who filled out the questionnaire about their child's behaviour.
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Angold A, 2007, J CHILD PSYCHOL PSYC, V48, P961, DOI 10.1111/j.1469-7610.2007.01832.x
   [Anonymous], 1992, INT STAT CLASS DIS R
   Beernink ACE, 2007, EUR CHILD ADOLES PSY, V16, P271, DOI 10.1007/s00787-007-0600-9
   Bradley RH, 2002, ANNU REV PSYCHOL, V53, P371, DOI 10.1146/annurev.psych.53.100901.135233
   Briggs-Gowan MJ, 2006, J AM ACAD CHILD PSY, V45, P849, DOI 10.1097/01.chi.0000220849.48650.59
   Carter A. S., 2000, INFANT TODDLER SOCIA
   Carter AS, 2004, J CHILD PSYCHOL PSYC, V45, P109, DOI 10.1046/j.0021-9630.2003.00316.x
   Carter AS, 2003, J ABNORM CHILD PSYCH, V31, P495, DOI 10.1023/A:1025449031360
   Costello AB, 2005, PRACTICAL ASSESSMENT, V10, P1, DOI DOI 10.1316/S0782-051X03024046-9
   DeHart G. B., 2004, CHILD DEV ITS NATURE
   Dereu M, 2012, EUR CHILD ADOLES PSY, V21, P541, DOI 10.1007/s00787-012-0280-y
   Dietz C, 2006, J AUTISM DEV DISORD, V36, P713, DOI 10.1007/s10803-006-0114-1
   Donders ART, 2006, J CLIN EPIDEMIOL, V59, P1087, DOI 10.1016/j.jclinepi.2006.01.014
   Egger HL, 2006, J CHILD PSYCHOL PSYC, V47, P313, DOI 10.1111/j.1469-7610.2006.01618.x
   Egger HL, 2011, AM PSYCHOL, V66, P95, DOI 10.1037/a0021026
   Fernell E, 2010, RES DEV DISABIL, V31, P790, DOI 10.1016/j.ridd.2010.02.003
   Ivanova MY, 2010, J AM ACAD CHILD PSY, V49, P1215, DOI 10.1016/j.jaac.2010.08.019
   Kjellmer L, 2012, RES DEV DISABIL, V33, P172, DOI 10.1016/j.ridd.2011.09.003
   Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1
   Mathiesen KS, 2000, J ABNORM CHILD PSYCH, V28, P15, DOI 10.1023/A:1005165916906
   McCutcheon AL, 1987, LATENT CLASS ANAL
   Mesman J, 2001, J CHILD PSYCHOL PSYC, V42, P679, DOI 10.1017/S0021963001007351
   Moricke E, 2012, DIFFERENTIAL STABILI
   Moricke E, 2010, EUR CHILD ADOLES PSY, V19, P659, DOI 10.1007/s00787-010-0103-y
   Muthen LK, 2006, MPLUS USERS GUIDE ST
   Nylund KL, 2007, STRUCT EQU MODELING, V14, P535
   Postert C, 2009, CHILD PSYCHIAT HUM D, V40, P25, DOI 10.1007/s10578-008-0113-x
   Sameroff A J, 1998, Pediatrics, V102, P1287
   Scheeringa MS, 2001, CHILD PSYCHIAT HUM D, V32, P71, DOI 10.1023/A:1017511714145
   Skovgaard AM, 2004, EUR CHILD ADOLES PSY, V13, P337, DOI 10.1007/s00787-004-0393-z
   Skovgaard AM, 2007, J CHILD PSYCHOL PSYC, V48, P62, DOI 10.1111/j.1469-7610.2006.01659.x
   Skovgaard AM, 2008, J CHILD PSYCHOL PSYC, V49, P553, DOI 10.1111/j.1469-7610.2007.01860.x
   Sonuga-Barke EJS, 2010, J CHILD PSYCHOL PSYC, V51, P368, DOI 10.1111/j.1469-7610.2009.02195.x
   Sparrow SS, 1997, VINELAND SOCIAL EMOT
   Statistical Package for Social Sciences, 2009, SPSS WIND REL 17 0
   Swinkels SHN, 2006, J AUTISM DEV DISORD, V36, P723, DOI 10.1007/s10803-006-0115-0
   Tavakol M., 2011, J MED EDUC, V2, P53
   Van Gessel-Dabekausen G, 2002, CHILD CARE OPVANG KI
   Veness C, 2012, AUTISM, V16, P163, DOI 10.1177/1362361311399936
   Volkmar F, 2005, ANNU REV PSYCHOL, V56, P315, DOI 10.1146/annurev.psych.56.091103.070159
   Yirmiya N, 2010, J CHILD PSYCHOL PSYC, V51, P432, DOI 10.1111/j.1469-7610.2010.02214.x
   Zeanah CH, 1997, J CHILD PSYCHOL PSYC, V38, P81, DOI 10.1111/j.1469-7610.1997.tb01506.x
   Zeanah CH, 1997, J AM ACAD CHILD PSY, V36, P165, DOI 10.1097/00004583-199702000-00007
   Zero to Three, 2005, DIAGN CLASS 0 3 R DI
NR 46
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD FEB
PY 2013
VL 22
IS 2
BP 103
EP 115
DI 10.1007/s00787-012-0332-3
PG 13
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 082RD
UT WOS:000314409100006
PM 23076366
ER

PT J
AU Lauritsen, MB
AF Lauritsen, Marlene Briciet
TI Autism spectrum disorders
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Review
DE Autism spectrum disorder; Autism; Diagnosis; DSM; ICD
ID ASPERGER-SYNDROME; CHILDREN; IDENTIFICATION; DIAGNOSIS; INFANCY; SIGNS
AB The revision of the diagnostic criteria for ASD has been widely anticipated and is expected to be an important contribution to the refinement of the definition of ASD. In the upcoming DSM-5, several changes have been made compared to the previous diagnostic criteria. They include no emphasis on language delay and age of onset except that ASD is defined as a neurodevelopmental disorder with symptoms in early childhood although the disorder may first be diagnosed later in life. The three areas of impairments in ASD are reduced to two areas, namely a social-communication domain and a behavioral domain including fixated interests and repetitive behaviors. In addition, the clinical presentation of ASD in the individual is described in more detail in terms of clinical specifiers. In addition to reporting these changes in the classification, the major international guidelines are introduced and a brief description of good clinical practice of assessment and the overall principles of intervention is provided.
C1 Aarhus Univ Hosp, Res Unit Child & Adolescent Psychiat, Aalborg Psychiat Hosp, DK-9000 Aalborg, Denmark.
RP Lauritsen, MB (reprint author), Aarhus Univ Hosp, Res Unit Child & Adolescent Psychiat, Aalborg Psychiat Hosp, Mollepk Vej 10, DK-9000 Aalborg, Denmark.
EM marlene.lauritsen@rn.dk
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Barbaro J, 2009, J DEV BEHAV PEDIATR, V30, P447, DOI 10.1097/DBP.0b013e3181ba0f9f
   Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
   Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   Ministries of Health and Education, 2008, NZ AUT SPECTR DIS GU
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   National Collaborating Centre for Woman's and Children's Health, 2011, AUT REC REF DIAGN CH
   Ozonoff S, 2008, AUTISM RES, V1, P320, DOI 10.1002/aur.53
   Palmer E, 2011, ARCH DIS CHILD, V96, P473, DOI 10.1136/adc.2009.172825
   Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
   Ronald A, 2010, BEHAV GENET, V40, P31, DOI 10.1007/s10519-009-9308-6
   Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
   Scottish Intercollegiate Guidelines Network, 2007, ASS DIAGN CLIN INT C
   Sharma S, 2011, AUTISM, V16, P465
   Walker DR, 2004, J AM ACAD CHILD PSY, V43, P172, DOI 10.1097/01.chi.0000101375.03068.db
   WHO, 1993, ICD 10 CLASS MENT BE
   Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2
   Yirmiya N, 2010, J CHILD PSYCHOL PSYC, V51, P432, DOI 10.1111/j.1469-7610.2010.02214.x
NR 20
TC 9
Z9 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1018-8827
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD FEB
PY 2013
VL 22
SU 1
BP S37
EP S42
DI 10.1007/s00787-012-0359-5
PG 6
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 081IH
UT WOS:000314311700007
PM 23300017
ER

PT J
AU Lindstrom, JH
AF Lindstrom, Jennifer H.
TI Introduction to the Special Issue: Response to Intervention within the
   Context of Specific Learning Disabilities, Emotional Disturbance, Autism
   Spectrum Disorders, and Early Childhood Special Education
SO EXCEPTIONALITY
LA English
DT Article
ID RISK
C1 Univ Georgia, Athens, GA 30602 USA.
RP Lindstrom, JH (reprint author), Univ Georgia, 570 Aderhold Hall, Athens, GA 30602 USA.
EM jhl@uga.edu
CR Ball CR, 2011, PSYCHOL SCHOOLS, V48, P502, DOI 10.1002/pits.20572
   Cheney D, 2008, J SPEC EDUC, V42, P108, DOI 10.1177/0022466907313349
   Fairbanks S, 2007, EXCEPT CHILDREN, V73, P288
   Gresham F. M., 2008, BEST PRACTICES SCH P, P281
   Gresham F. M., 2007, HDB RESPONSE INTERVE, V1, P10
   Ihlo T., 2010, PROMISE RESPONSE INT, P239
   McIntosh K., 2010, COMMUNIQUE, V39, P30
   Posney A., 2010, COMMUNICATION
   Samuels C. A., 2011, ED WEEK, pS1
   Smith S. L., 2010, COMMUNIQUE, V38, P9
   Wiener R. M., 2008, J SPECIAL ED LEADERS, V21, P39
   Wilkinson L. A., 2010, BEST PRACTICE GUIDE
   Zirkel P. A., 2011, COMMUNIQUE, V39
   Zirkel P. A., 2003, W ED LAW REPORTER, V171, P391
NR 14
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0936-2835
J9 EXCEPTIONALITY
JI Exceptionality
PD FEB 1
PY 2013
VL 21
IS 1
SI SI
BP 1
EP 4
DI 10.1080/09362835.2013.750109
PG 4
WC Education, Special
SC Education & Educational Research
GA 081UB
UT WOS:000314346800001
ER

PT J
AU Hammond, RK
   Campbell, JM
   Ruble, LA
AF Hammond, Rachel K.
   Campbell, Jonathan M.
   Ruble, Lisa A.
TI Considering Identification and Service Provision for Students with
   Autism Spectrum Disorders within the Context of Response to Intervention
SO EXCEPTIONALITY
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; CHILDREN; PREVENTION; PREVALENCE; MODELS; RTI;
   CLASSROOMS; DIAGNOSIS; SAMPLE; AGE
AB The Response to Intervention (RTI) framework, a preventive model of universal screening, tiered interventions, and ongoing progress monitoring, poses an interesting consideration for identification and service delivery for children with autism spectrum disorders (ASD). Upon examination of the existing literature, paucity exists regarding how RTI might guide identification and service delivery for students with ASD; however, the authors consider core tenets of RTI and how they are relevant for students with ASD given what is known about this unique population. Due to the importance of early identification and interventions for individuals with ASD, the RTI framework could be problematic if used to delay education eligibility. Thus, two routes of identification are outlined by the authors, one of which expedites evaluation based on pervasive symptomatology, while the other route uses a form of universal screening to assist in moving toward evaluation for those suspected of ASD. The use of tiered interventions for prevention or service delivery could cause potential complications given the need for early identification and individualized intensive programming. However, there is a clear match for several instructional RTI components and ASD, specifically for evidence-based interventions that are implemented with fidelity and monitored frequently, and other aspects such as family involvement, which could improve programming for students with ASD.
C1 [Hammond, Rachel K.] Univ Kentucky, Sch Psychol Program, Lexington, KY 40506 USA.
RP Hammond, RK (reprint author), Univ Kentucky, Sch Psychol Program, 170 G Taylor Educ Bldg, Lexington, KY 40506 USA.
EM rachel.hammond@uky.edu
CR Allen RA, 2008, PSYCHOL SCHOOLS, V45, P905, DOI 10.1002/pits.20341
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Barger BD, 2013, J AUTISM DEV DISORD, V43, P817, DOI 10.1007/s10803-012-1621-x
   Berkeley S, 2009, J LEARN DISABIL-US, V42, P85, DOI 10.1177/0022219408326214
   Brown-Chidsey R, 2007, EDUC LEADERSHIP, V65, P40
   Campbell J., AUTISM SPECTRUM DISO
   Caplan G, 1994, J Prim Prev, V15, P15, DOI 10.1007/BF02196344
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Colorado Department of Education, 2008, RESP INT RTI PRACT G
   Crosland K, 2012, BEHAV MODIF, V36, P251, DOI 10.1177/0145445512442682
   De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
   Eddy JM, 2000, J EMOT BEHAV DISORD, V8, P165, DOI 10.1177/106342660000800304
   Ehlers S, 1999, J AUTISM DEV DISORD, V29, P129, DOI 10.1023/A:1023040610384
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Florida Department of Education, 2004, RUL 6 A 6 0331 ID DE
   Fuchs D, 2012, EXCEPT CHILDREN, V78, P263
   German G., 2010, INTERVENTIONS ACHIEV, pxxiii
   Good R. H., 2011, DYNAMIC INDICATORS B
   Granpeesheh D, 2009, RES AUTISM SPECT DIS, V3, P1014, DOI 10.1016/j.rasd.2009.06.007
   Gresham F. M., 2008, BEST PRACTICES SCH P, P281
   Gresham F. M., 2007, HDB RESPONSE INTERVE, V1, P10
   Hess KL, 2008, J AUTISM DEV DISORD, V38, P961, DOI 10.1007/s10803-007-0470-5
   Hosp M. K., 2007, ABCS CBM PRACTICAL G
   Hughes CA, 2011, THEOR PRACT, V50, P4, DOI 10.1080/00405841.2011.534909
   IDEA Partnership, 2010, AUT SPECTR DIS ASD C
   Ikeda M. J., 2008, BEST PRACTICES SCH P, V5, P103
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Johnson E, 2005, J LEARN DISABIL-US, V38, P569, DOI 10.1177/00222194050380061401
   Kazdin A. E., 2005, PARENT MANAGEMENT TR
   Kratochwill TR, 2007, SCHOOL PSYCHOL REV, V36, P618
   Lembke ES, 2010, READ WRIT Q, V26, P361, DOI 10.1080/10573569.2010.500266
   Lord C., 2001, ED CHILDREN AUTISM
   Mandell DS, 2010, PSYCHIAT SERV, V61, P822, DOI 10.1176/appi.ps.61.8.822
   Mayes SD, 2008, J AUTISM DEV DISORD, V38, P428, DOI 10.1007/s10803-007-0410-4
   McCook J. E., 2012, M NAT CHILDR EXC CHI
   Mellard DF, 2011, FOCUS EXCEPT CHILD, V43, P1
   Musgrove M., 2011, RESPONSE INTERVENTIO
   Nation K, 2006, J AUTISM DEV DISORD, V36, P911, DOI 10.1007/s10803-006-0130-1
   National Autism Center, 2009, EV BAS PRACT AUT SCH
   National Center on Response to Intervention, 2010, ESS COP RTI CLOS LOO
   Perry A, 2011, RES AUTISM SPECT DIS, V5, P592, DOI 10.1016/j.rasd.2010.07.003
   Power T. J., 2010, INTERVENTIONS ACHIEV, P151
   RTI Action Network, 2012, TIER INSTR INT RESP
   Ruble L, 2012, J AUTISM DEV DISORD, V42, P1974, DOI 10.1007/s10803-012-1446-7
   Ruble LA, 2010, J EARLY INTERVENTION, V32, P286, DOI 10.1177/1053815110382973
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sansosti FJ, 2010, PSYCHOL SCHOOLS, V47, P257, DOI 10.1002/pits.20469
   Schwartz I. S., 2008, BEST PRACTICES SCH P, P1517
   Shapiro E. S., 2010, INTERVENTIONS ACHIEV, P175
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Skokauskas N, 2010, PSYCHOPATHOLOGY, V43, P8, DOI 10.1159/000255958
   Sugai G., 2002, INTERVENTIONS ACAD B, P315
   Tobin R. M., 2008, BEST PRACTICES SCH P, VV, P617
   Walker H.M., 2010, INTERVENTIONS ACHIEV, pxxiii
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005
   Wilkinson L. A., 2010, BEST PRACTICE GUIDE
   Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
NR 58
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0936-2835
J9 EXCEPTIONALITY
JI Exceptionality
PD FEB 1
PY 2013
VL 21
IS 1
SI SI
BP 34
EP 50
DI 10.1080/09362835.2013.750119
PG 17
WC Education, Special
SC Education & Educational Research
GA 081UB
UT WOS:000314346800004
ER

PT J
AU Paonessa, F
   Latifi, S
   Scarongella, H
   Cesca, F
   Benfenati, F
AF Paonessa, Francesco
   Latifi, Shahrzad
   Scarongella, Helena
   Cesca, Fabrizia
   Benfenati, Fabio
TI Specificity Protein 1 (Sp1)-dependent Activation of the Synapsin I Gene
   (SYN1) Is Modulated by RE1-silencing Transcription Factor (REST) and 5
   '-Cytosine-Phosphoguanine (CpG) Methylation
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID DNA METHYLATION; TATA-LESS; SYNAPTIC VESICLES; NEURONAL GENES;
   MOUSE-BRAIN; EXPRESSION; PROMOTER; SP1; REPRESSOR; BINDING
AB The development and function of the nervous system are directly dependent on a well defined pattern of gene expression. Indeed, perturbation of transcriptional activity or epigenetic modifications of chromatin can dramatically influence neuronal phenotypes. The phosphoprotein synapsin I (Syn I) plays a crucial role during axonogenesis and synaptogenesis as well as in synaptic transmission and plasticity of mature neurons. Abnormalities in SYN1 gene expression have been linked to important neuropsychiatric disorders, such as epilepsy and autism. SYN1 gene transcription is suppressed in non-neural tissues by the RE1-silencing transcription factor (REST); however, the molecular mechanisms that allow the constitutive expression of this genetic region in neurons have not been clarified yet. Herein we demonstrate that a conserved region of human and mouse SYN1 promoters contains cis-sites for the transcriptional activator Sp1 in close proximity to REST binding motifs. Through a series of functional assays, we demonstrate a physical interaction of Sp1 on the SYN1 promoter and show that REST directly inhibits Sp1-mediated transcription, resulting in SYN1 down-regulation. Upon differentiation of neuroblastoma Neuro2a cells, we observe a decrease in endogenous REST and a higher stability of Sp1 on target GC boxes, resulting in an increase of SYN1 transcription. Moreover, methylation of Sp1 cis-sites in the SYN1 promoter region could provide an additional level of transcriptional regulation. Our results introduce Sp1 as a fundamental activator of basal SYN1 gene expression, whose activity is modulated by the neural master regulator REST and CpG methylation.
C1 [Paonessa, Francesco; Latifi, Shahrzad; Scarongella, Helena; Cesca, Fabrizia; Benfenati, Fabio] Ist Italiano Tecnol, Dept Neurosci & Brain Technol, I-16163 Genoa, Italy.
RP Benfenati, F (reprint author), Ist Italiano Tecnol, Via Morego 30, I-16163 Genoa, Italy.
EM fabio.benfenati@iit.it
FU Italian Ministry of University and Research (PRIN); Compagnia di San
   Paolo, Torino, Italy; Telethon-Italy [GGP09134]
FX This study was supported by research grants from the Italian Ministry of
   University and Research (PRIN) and the Compagnia di San Paolo, Torino,
   Italy. The support of Telethon-Italy (Grant GGP09134) is also
   acknowledged.
CR Andres ME, 1999, P NATL ACAD SCI USA, V96, P9873, DOI 10.1073/pnas.96.17.9873
   Babu H, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000388
   Babu H, 2011, FRONT NEUROSCI-SWITZ, V5, DOI 10.3389/fnins.2011.00089
   Baldelli P, 2007, J NEUROSCI, V27, P13520, DOI 10.1523/JNEUROSCI.3151-07.2007
   Bassuk AG, 2008, AM J HUM GENET, V83, P572, DOI 10.1016/j.ajhg.2008.10.003
   Bogen IL, 2009, NEUROSCIENCE, V158, P231, DOI 10.1016/j.neuroscience.2008.05.055
   Butta N, 2006, BMC MOL BIOL, V7, DOI 10.1186/1471-2199-7-17
   Cao YX, 2000, BIOCHEM J, V350, P883, DOI 10.1042/0264-6021:3500883
   Cartharius K, 2005, BIOINFORMATICS, V21, P2933, DOI 10.1093/bioinformatics/bti473
   Cesca F, 2010, PROG NEUROBIOL, V91, P313, DOI 10.1016/j.pneurobio.2010.04.006
   Chang L., 2011, MOL CANCER RES, V9, P1
   Chestnut BA, 2011, J NEUROSCI, V31, P16619, DOI 10.1523/JNEUROSCI.1639-11.2011
   Chiappalone M, 2009, CEREB CORTEX, V19, P1422, DOI 10.1093/cercor/bhn182
   Clark SJ, 1997, GENE, V195, P67, DOI 10.1016/S0378-1119(97)00164-9
   Clinton M., 2000, GENOME BIOL, V1
   Corradi A, 2008, J CELL SCI, V121, P3042, DOI 10.1242/jcs.035063
   Ekici M, 2008, NEUROCHEM INT, V53, P165, DOI 10.1016/j.neuint.2008.07.006
   Fassio A, 2011, HUM MOL GENET, V20, P2297, DOI 10.1093/hmg/ddr122
   Feng J, 2010, NAT NEUROSCI, V13, P423, DOI 10.1038/nn.2514
   Futscher BW, 2002, NAT GENET, V31, P175, DOI 10.1038/ng886
   Grimes JA, 2000, J BIOL CHEM, V275, P9461, DOI 10.1074/jbc.275.13.9461
   HAGEN G, 1994, EMBO J, V13, P3843
   HOESCHE C, 1993, J BIOL CHEM, V268, P26494
   Huber R, 1998, GENE, V214, P35, DOI 10.1016/S0378-1119(98)00233-9
   James AB, 2004, CELL SIGNAL, V16, P1355, DOI 10.1016/j.cellsig.2004.04.001
   JUNGLING S, 1994, EUR J BIOCHEM, V226, P925, DOI 10.1111/j.1432-1033.1994.00925.x
   Kitazawa S, 1999, J BIOL CHEM, V274, P28787, DOI 10.1074/jbc.274.40.28787
   KUDO S, 1995, J BIOL CHEM, V270, P13298
   Kudo S, 1998, MOL CELL BIOL, V18, P5492
   Ladd-Acosta C, 2007, AM J HUM GENET, V81, P1304, DOI 10.1086/524110
   Lein ES, 2007, NATURE, V445, P168, DOI 10.1038/nature05453
   Li LC, 2002, BIOINFORMATICS, V18, P1427, DOI 10.1093/bioinformatics/18.11.1427
   Lietz M, 2003, EUR J BIOCHEM, V270, P2, DOI 10.1046/j.1432-1033.2003.03360.x
   Lietz M, 1998, BIOL CHEM, V379, P1301
   Lunyak VV, 2002, SCIENCE, V298, P1747, DOI 10.1126/science.1076469
   Mody M, 2001, P NATL ACAD SCI USA, V98, P8862, DOI 10.1073/pnas.141244998
   Ooi L, 2007, NAT REV GENET, V8, P544, DOI 10.1038/nrg2100
   Palm K, 1999, MOL BRAIN RES, V72, P30, DOI 10.1016/S0169-328X(99)00196-5
   Palm K, 1998, J NEUROSCI, V18, P1280
   Park SY, 2007, J NEUROCHEM, V103, P2565, DOI 10.1111/j.1471-4159.2007.04947.x
   Philipsen S, 1999, NUCLEIC ACIDS RES, V27, P2991, DOI 10.1093/nar/27.15.2991
   Plaisance V, 2005, J BIOL CHEM, V280, P401, DOI 10.1074/jbc.M411825200
   Rivero S, 2011, BMC MOL BIOL, V12, DOI 10.1186/1471-2199-12-52
   ROSAHL TW, 1995, NATURE, V375, P488, DOI 10.1038/375488a0
   SAUERWALD A, 1990, J BIOL CHEM, V265, P14932
   Schoch S, 1996, J BIOL CHEM, V271, P3317
   SCHOENHERR CJ, 1995, SCIENCE, V267, P1360, DOI 10.1126/science.7871435
   Strathdee G, 2004, CARCINOGENESIS, V25, P693, DOI 10.1093/carcin/bgh066
   Strathdee G, 2004, BIOCHEM SOC T, V32, P913
   Sunkin SM, 2007, HUM MOL GENET, V16, pR209, DOI 10.1093/hmg/ddm183
   THIEL G, 1991, P NATL ACAD SCI USA, V88, P3431, DOI 10.1073/pnas.88.8.3431
   THIEL G, 1994, J BIOL CHEM, V269, P15294
   Wierstra I, 2008, BIOCHEM BIOPH RES CO, V372, P1, DOI 10.1016/j.bbrc.2008.03.074
   Wood IC, 2003, J MOL BIOL, V334, P863, DOI 10.1016/j.jmb.2003.10.017
   Zhu Q, 2012, J MOL NEUROSCI, V46, P420, DOI 10.1007/s12031-011-9602-7
   Zuccato C, 2003, NAT GENET, V35, P76, DOI 10.1038/ng1219
NR 56
TC 5
Z9 5
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD FEB 1
PY 2013
VL 288
IS 5
BP 3227
EP 3239
DI 10.1074/jbc.M112.399782
PG 13
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 082NE
UT WOS:000314397900030
PM 23250796
ER

PT J
AU de Kwaadsteniet, L
   Kim, NS
   Yopchick, JE
AF de Kwaadsteniet, Leontien
   Kim, Nancy S.
   Yopchick, Jennelle E.
TI How do practising clinicians and students apply newly learned causal
   information about mental disorders?
SO JOURNAL OF EVALUATION IN CLINICAL PRACTICE
LA English
DT Article
DE causal knowledge; clinical expertise; clinical reasoning; continuing
   education; diagnosis; mental disorders
ID CATEGORY-BASED INDUCTION; JUDGMENTS; BEHAVIOR; THERAPY; AUTISM
AB Rationale, aims and objectives New causal theories explaining the aetiology of psychiatric disorders continuously appear in the literature. How might such new information directly impact clinical practice, to the degree that clinicians are aware of it and accept it? We investigated whether expert clinical psychologists and students use new causal information about psychiatric disorders according to rationalist norms in their diagnostic reasoning. Specifically, philosophical and Bayesian analyses suggest that it is rational to draw stronger inferences about the presence of a disorder when a client's presenting symptoms are from disparate locations in a causal theory of the disorder than when they are from proximal locations. Method In a controlled experiment, we presented experienced clinical psychologists and students with recently published causal theories for different disorders; specifically, these theories proposed how the symptoms of each disorder stem from a root cause. Participants viewed hypothetical clients with presenting proximal or diverse symptoms, and indicated either the likelihood that the client has the disorder, or what additional information they would seek out to help inform a diagnostic decision. Results Clinicians and students alike showed a strong preference for diverse evidence, over proximal evidence, in making diagnostic judgments and in seeking additional information. They did not show this preference in the control condition, in which they gave their own opinions prior to learning the causal information. Conclusion These findings suggest that experienced clinical psychologists and students are likely to use newly learned causal knowledge in a normative, rational way in diagnostic reasoning.
C1 [de Kwaadsteniet, Leontien] Radboud Univ Nijmegen, NL-6525 HR Nijmegen, Netherlands.
   [Kim, Nancy S.; Yopchick, Jennelle E.] Northeastern Univ, Dept Psychol, Boston, MA 02115 USA.
RP de Kwaadsteniet, L (reprint author), Radboud Univ Nijmegen, Montessorilaan 3, NL-6525 HR Nijmegen, Netherlands.
EM l.dekwaadsteniet@socsci.ru.nl
CR Ahn WK, 2009, COGNITIVE SCI, V33, P147, DOI 10.1111/j.1551-6709.2009.01008.x
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bailenson JN, 2002, COGNITION, V84, P1, DOI 10.1016/S0010-0277(02)00011-2
   Belmonte MK, 2004, MOL PSYCHIATR, V9, P646, DOI 10.1038/sj.mp.4001499
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   De Kwaadsteniet L., 2009, THESIS RADBOUD U NIJ
   de Kwaadsteniet L, 2010, PSYCHOL ASSESSMENT, V22, P581, DOI 10.1037/a0019696
   Fairburn CG, 1999, BEHAV RES THER, V37, P1, DOI 10.1016/S0005-7967(98)00102-8
   Fairburn CG, 2003, BEHAV RES THER, V41, P509, DOI 10.1016/S0005-7967(02)00088-8
   Heit E., 1998, RATIONAL MODELS COGN, P248
   Heit E., 2005, CATEGORIZATION INSID, P87, DOI 10.1037/11156-006
   Horwich P., 1982, PROBABILITY EVIDENCE
   Kim NS, 2002, J EXP PSYCHOL GEN, V131, P451, DOI 10.1037//0096-3445.131.4.451
   Kim NS, 2008, PSYCHON B REV, V15, P81, DOI 10.3758/PBR.15.1.81
   Kim NS, 2003, MEM COGNITION, V31, P155, DOI 10.3758/BF03196090
   Kincannon A, 2003, MEM COGNITION, V31, P114, DOI 10.3758/BF03196087
   LOPEZ A, 1995, MEM COGNITION, V23, P374, DOI 10.3758/BF03197238
   Mauchnik J., 2005, DIRECTIONS PSYCHIAT, V25, P197
   Medin DL, 2003, PSYCHON B REV, V10, P517, DOI 10.3758/BF03196515
   Morton J., 2004, UNDERSTANDING DEV DI
   Murphy G. L., 2002, BIG BOOK CONCEPTS
   Ninan T. N., 2005, J CLIN PSYCHIAT, V66, P3
   OSHERSON DN, 1990, PSYCHOL REV, V97, P185, DOI 10.1037/0033-295X.97.2.185
   Popper Karl, 1963, CONJECTURES REFUTATI
   Proctor C, 2007, PSYCHON B REV, V14, P635, DOI 10.3758/BF03196813
   Proffitt JB, 2000, J EXP PSYCHOL LEARN, V26, P811, DOI 10.1037//0278-7393.26.4.811
   Shrout P. E, 2011, CAUSALITY PSYCHOPATH, P3
   Sonuga-Barke EJS, 2002, BEHAV BRAIN RES, V130, P29, DOI 10.1016/S0166-4328(01)00432-6
   Spellman B. A., 1999, THINK REASONING, V5, P67, DOI 10.1080/135467899394084
   Yopchick JE, 2009, MEM COGNITION, V37, P29, DOI 10.3758/MC.37.1.29
NR 30
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1356-1294
J9 J EVAL CLIN PRACT
JI J. Eval. Clin. Pract.
PD FEB
PY 2013
VL 19
IS 1
BP 112
EP 117
DI 10.1111/j.1365-2753.2011.01781.x
PG 6
WC Health Care Sciences & Services; Medical Informatics; Medicine, General
   & Internal
SC Health Care Sciences & Services; Medical Informatics; General & Internal
   Medicine
GA 078QN
UT WOS:000314114400017
PM 22029432
ER

PT J
AU Bayliss, AP
   Murphy, E
   Naughtin, CK
   Kritikos, A
   Schilbach, L
   Becker, SI
AF Bayliss, Andrew P.
   Murphy, Emily
   Naughtin, Claire K.
   Kritikos, Ada
   Schilbach, Leonhard
   Becker, Stefanie I.
TI "Gaze Leading": Initiating Simulated Joint Attention Influences Eye
   Movements and Choice Behavior
SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
LA English
DT Article
DE joint attention; gaze perception; social cognition; eye tracking;
   preferences
ID VISUAL-ATTENTION; INDIVIDUAL-DIFFERENCES; SOCIAL ATTENTION;
   SEX-DIFFERENCES; AUTISM; DIRECTION; CHILDREN; FACE; JUDGMENTS; AMYGDALA
AB Recent research in adults has made great use of the gaze cuing paradigm to understand the behavior of the follower in joint attention episodes. We implemented a gaze leading task to investigate the initiator the other person in these triadic interactions. In a series of gaze-contingent eye-tracking studies, we show that fixation dwell time upon and reorienting toward a face are affected by whether that individual face shifts its eyes in a congruent or an incongruent direction in response to the participant's eye movement. Gaze leading also biased affective responses toward the faces and attended objects. These findings demonstrate that leading the eyes of other individuals alters how we explore and evaluate our social environment.
C1 [Bayliss, Andrew P.] Univ E Anglia, Sch Psychol, Norwich NR4 7TJ, Norfolk, England.
   [Murphy, Emily; Naughtin, Claire K.; Kritikos, Ada] Univ Queensland, Sch Psychol, St Lucia, Qld, Australia.
   [Schilbach, Leonhard] Univ Hosp Cologne, Dept Psychiat, Cologne, Germany.
   [Schilbach, Leonhard] Max Planck Inst Neurol Res, Cort Networks, D-50931 Cologne, Germany.
   [Becker, Stefanie I.] Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia.
RP Bayliss, AP (reprint author), Univ E Anglia, Sch Psychol, Norwich NR4 7TJ, Norfolk, England.
EM apbayliss@gmail.com
RI Schilbach, Leonhard/G-5832-2010
OI Schilbach, Leonhard/0000-0001-5547-8309
CR Alwall N, 2010, PERS INDIV DIFFER, V49, P729, DOI 10.1016/j.paid.2010.06.016
   Argyle Michael, 1976, GAZE AND MUTUAL GAZE
   Baron-Cohen S., 1995, JOINT ATTENTION ITS, P41
   Bayliss AP, 2010, VIS COGN, V18, P1214, DOI 10.1080/13506285.2010.484657
   Bayliss AP, 2005, BRIT J PSYCHOL, V96, P95, DOI 10.1348/000712604X15626
   Bayliss AP, 2009, EUR J COGN PSYCHOL, V21, P1072, DOI 10.1080/09541440802553490
   Bayliss AP, 2007, COGNITION, V104, P644, DOI 10.1016/j.cognition.2006.07.012
   Bayliss AP, 2005, Q J EXP PSYCHOL-A, V58, P631, DOI 10.1080/02724980443000124
   Bayliss AP, 2006, PSYCHON B REV, V13, P1061, DOI 10.3758/BF03213926
   Bayliss AP, 2006, PSYCHOL SCI, V17, P514, DOI 10.1111/j.1467-9280.2006.01737.x
   Bayliss AP, 2011, J EXP PSYCHOL HUMAN, V37, P634, DOI 10.1037/a0020559
   Becchio C, 2008, TRENDS COGN SCI, V12, P254, DOI 10.1016/j.tics.2008.04.005
   Bockler A, 2011, COGNITION, V120, P292, DOI 10.1016/j.cognition.2011.05.002
   Carpenter M., 1998, MONOGR SOC RES CHILD, V63, P1, DOI DOI 10.2307/1166214
   Charman T, 2000, COGNITIVE DEV, V15, P481, DOI 10.1016/S0885-2014(01)00037-5
   Chiappe D., 2004, EVOLUTIONARY PSYCHOL, V2, P108
   Corkum V., 1995, JOINT ATTENTION ITS, P61
   Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
   Decety J, 2003, TRENDS COGN SCI, V7, P527, DOI 10.1016/j.tics.2003.10.004
   Driver J, 1999, VIS COGN, V6, P509
   Emery NJ, 2000, NEUROSCI BIOBEHAV R, V24, P581, DOI 10.1016/S0149-7634(00)00025-7
   Farroni T, 2000, VIS COGN, V7, P705
   Feinman S., 1992, SOCIAL REFERENCING S, P15
   Franco F, 2009, SOC DEV, V18, P51, DOI 10.1111/j.1467-9507.2008.00464.x
   Friesen CK, 1998, PSYCHON B REV, V5, P490, DOI 10.3758/BF03208827
   Frischen A, 2007, PSYCHOL BULL, V133, P694, DOI 10.1037/0033-2909.133.4.694
   Gallup A. C., 2012, BIOL LETT, DOI 10.1098.rsbl.2012.0160
   Gallup AC, 2012, P NATL ACAD SCI USA, V109, P7245, DOI 10.1073/pnas.1116141109
   JOHNSON MH, 1991, COGNITION, V40, P1, DOI 10.1016/0010-0277(91)90045-6
   KLEINKE CL, 1986, PSYCHOL BULL, V100, P78, DOI 10.1037//0033-2909.100.1.78
   Krajbich I, 2010, NAT NEUROSCI, V13, P1292, DOI 10.1038/nn.2635
   Kuhn G, 2010, EXP BRAIN RES, V201, P155, DOI 10.1007/s00221-009-2019-7
   Laidlaw KEW, 2011, P NATL ACAD SCI USA, V108, P5548, DOI 10.1073/pnas.1017022108
   Leekam SR, 2000, DEV PSYCHOL, V36, P261, DOI 10.1037/0012-1649.36.2.261
   Lewin C, 2002, BRAIN COGNITION, V50, P121, DOI 10.1016/S0278-2626(02)00016-7
   Lobmaier JS, 2006, EXP PSYCHOL, V53, P117, DOI 10.1027/1618-3469.53.2.117
   LOFTUS GR, 1994, PSYCHON B REV, V1, P476, DOI 10.3758/BF03210951
   Mathews A, 2003, VIS COGN, V10, P823, DOI 10.1080/13506280344000095
   Moore C, 2001, J COGN DEV, V2, P109, DOI 10.1207/S15327647JCD0202_1
   Moore C, 2008, CHILD DEV PERSPECT, V2, P66, DOI 10.1111/j.1750-8606.2008.00052.x
   Morales M, 1998, INFANT BEHAV DEV, V21, P373, DOI 10.1016/S0163-6383(98)90014-5
   Mosconi MW, 2009, ARCH GEN PSYCHIAT, V66, P509, DOI 10.1001/archgenpsychiatry.2009.19
   Mumme DL, 2003, CHILD DEV, V74, P221, DOI 10.1111/1467-8624.00532
   Mundy P, 2007, CURR DIR PSYCHOL SCI, V16, P269, DOI 10.1111/j.1467-8721.2007.00518.x
   Mundy P, 1998, INFANT BEHAV DEV, V21, P469, DOI 10.1016/S0163-6383(98)90020-0
   MUNDY P, 1995, DEV PSYCHOPATHOL, V7, P63
   Mundy P., 2005, HDB AUTISM PERVASIVE, V1, P650
   Nichols KE, 2005, INFANCY, V7, P35, DOI 10.1207/s15327078in0701_4
   Nuku P, 2008, CONSCIOUS COGN, V17, P339, DOI 10.1016/j.concog.2007.06.014
   Ohman A, 2005, PSYCHONEUROENDOCRINO, V30, P953, DOI 10.1016/j.psyneuen.2005.03.019
   POULTON EC, 1982, PSYCHOL BULL, V91, P673, DOI 10.1037/0033-2909.91.3.673
   Redcay E., 2010, NEUROIMAGE, V50, P39
   Research Network on Early Experience and Brain Development, 2002, NIMSTIM FAC STIM SET
   Ristic J, 2005, COGNITIVE BRAIN RES, V24, P715, DOI 10.1016/j.cogbrainres.2005.02.007
   SCAIFE M, 1975, NATURE, V253, P265, DOI 10.1038/253265a0
   Schilbach L, 2010, J COGNITIVE NEUROSCI, V22, P2702, DOI 10.1162/jocn.2009.21401
   Schilbach L., BEHAV BRAI IN PRESS
   Schilbach L, 2012, AUTISM, V16, P151, DOI 10.1177/1362361311409258
   Schilbach Leonhard, 2010, Nat Rev Neurosci, V11, P449, DOI 10.1038/nrn2805-c1
   Schneider D., PSYCHOL SCI IN PRESS
   Schneider D, 2012, J EXP PSYCHOL GEN, V141, P433, DOI 10.1037/a0025458
   Schotter ER, 2010, VIS COGN, V18, P1113, DOI 10.1080/13506281003668900
   Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
   Shimojo S, 2003, NAT NEUROSCI, V6, P1317, DOI 10.1038/nn1150
   TELLER DY, 1979, INFANT BEHAV DEV, V2, P135, DOI 10.1016/S0163-6383(79)80016-8
   Teufel C, 2010, ATTEN PERCEPT PSYCHO, V72, P695, DOI 10.3758/APP.72.3.695
   Tipples J, 2002, PSYCHON B REV, V9, P314, DOI 10.3758/BF03196287
   Tottenham N, 2009, PSYCHIAT RES, V168, P242, DOI 10.1016/j.psychres.2008.05.006
   Whalen PJ, 2004, SCIENCE, V306, P2061, DOI 10.1126/science.1103617
   Williams JHG, 2005, NEUROIMAGE, V25, P133, DOI 10.1016/j.neuroimage.2004.10.047
   Wilms M, 2010, SOC COGN AFFECT NEUR, V5, P98, DOI 10.1093/scan/nsq024
NR 71
TC 2
Z9 2
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0096-3445
J9 J EXP PSYCHOL GEN
JI J. Exp. Psychol.-Gen.
PD FEB
PY 2013
VL 142
IS 1
BP 76
EP 92
DI 10.1037/a0029286
PG 17
WC Psychology, Experimental
SC Psychology
GA 079SX
UT WOS:000314193600010
PM 22800442
ER

PT J
AU Flor, J
   Bellando, J
   Lopez, M
AF Flor, J.
   Bellando, J.
   Lopez, M.
TI DEVELOPMENTAL FUNCTIONING AND MEDICAL CO-MORBIDITY PROFILE OF CHILDREN
   WITH COMPLEX AND ESSENTIAL AUTISM
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Meeting Abstract
CT Southern Regional Meeting of the
   American-Federation-for-Medical-Research
CY FEB 21-23, 2013
CL New Orleans, LA
SP Amer Federat Med Res, So Reg
C1 [Flor, J.; Bellando, J.; Lopez, M.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA.
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1081-5589
J9 J INVEST MED
JI J. Invest. Med.
PD FEB
PY 2013
VL 61
IS 2
MA 45
BP 385
EP 386
PG 2
WC Medicine, General & Internal; Medicine, Research & Experimental
SC General & Internal Medicine; Research & Experimental Medicine
GA 079FO
UT WOS:000314156100059
ER

PT J
AU Sala, M
   Braida, D
   Donzelli, A
   Martucci, R
   Busnelli, M
   Bulgheroni, E
   Rubino, T
   Parolaro, D
   Nishimori, K
   Chini, B
AF Sala, M.
   Braida, D.
   Donzelli, A.
   Martucci, R.
   Busnelli, M.
   Bulgheroni, E.
   Rubino, T.
   Parolaro, D.
   Nishimori, K.
   Chini, B.
TI Mice Heterozygous for the Oxytocin Receptor Gene (Oxtr(+/-)) Show
   Impaired Social Behaviour but not Increased Aggression or Cognitive
   Inflexibility: Evidence of a Selective Haploinsufficiency Gene Effect
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE behavioural phenotype; oxytocin receptor; selective agonists
ID VASOPRESSIN 1B RECEPTOR; KNOCKOUT MOUSE; DEFICITS; ANXIETY; AUTISM;
   ANTIDEPRESSANTS; SCHIZOPHRENIA; PHARMACOLOGY; RECOGNITION; DISORDERS
AB We characterised the behavioural phenotype of mice heterozygous (Oxtr+/-) for the oxytocin receptor gene (Oxtr) and compared it with that of Oxtr null mice (Oxtr-/-), which display autistic-like behaviours, including impaired sociability and preference for social novelty, impaired cognitive flexibility, and increased aggression. Similar to Oxtr-/- mice, the Oxtr+/- showed impaired sociability and preference for social novelty but, unlike the null genotype, their cognitive flexibility and aggression were normal. By autoradiography, Oxtr+/- mice were found to have approximately 50% fewer oxytocin receptors (OXTRs) in all of the examined brain regions. Thus, because a partial reduction in Oxtr gene expression is sufficient to compromise social behaviour, the Oxtr acts as a haploinsufficient gene. Furthermore, the inactivation of the Oxtr gene affects specific behaviours in a dose-dependent manner: social behaviour is sensitive to even a partial reduction in Oxtr gene expression, whereas defects in aggression and cognitive flexibility require the complete inactivation of the Oxtr gene to emerge. We then investigated the rescue of the Oxtr+/- social deficits by oxytocin (OT) and Thr4Gly7OT (TGOT) administered i.c.v. at different doses. TGOT was more potent than OT in rescuing sociability and social novelty in both genotypes. Furthermore, the TGOT doses that reverted impaired sociability and preference for social novelty in Oxtr+/- were lower than those required in Oxtr-/-, thus suggesting that the rescue effect is mediated by OXTR in Oxtr+/- and by other receptors (presumably vasopressin V1a receptors) in Oxtr-/-. In line with this, a low dose of the selective oxytocin antagonist desGlyDTyrOVT blocks the rescue effect of TGOT only in the Oxtr+/- genotype, whereas the less selective antagonist SR49059 blocks rescue in both genotypes. In conclusion, the Oxtr+/- mouse is a unique animal model for investigating how partial loss of the Oxtr gene impair social interactions, and for designing pharmacological rescue strategies.
C1 [Sala, M.; Braida, D.; Donzelli, A.; Martucci, R.; Busnelli, M.; Chini, B.] Univ Milan, Dipartimento Biotecnol Med & Med Traslaz, Milan, Italy.
   [Sala, M.; Busnelli, M.; Bulgheroni, E.; Chini, B.] CNR, Inst Neurosci, I-20129 Milan, Italy.
   [Rubino, T.; Parolaro, D.] Univ Insubria, DBSF, Busto Arsizio, Varese, Italy.
   [Nishimori, K.] Tohoku Univ, Dept Mol & Cell Biol, Grad Sch Agr Sci, Sendai, Miyagi 980, Japan.
RP Chini, B (reprint author), CNR, Inst Neurosci, Via Vanvitelli 32, I-20129 Milan, Italy.
EM b.chini@in.cnr.it
FU Cariplo Foundation [2008.2314]; Regione Lombardia [16983 - Rif. SAL-50];
   PNR-CNR Aging program
FX The present study was supported by the Cariplo Foundation (Grant
   2008.2314 to B. C. and M. S.), the Regione Lombardia (Progetto
   TerDisMental, ID 16983 - Rif. SAL-50 to B. C.) and the PNR-CNR Aging
   program (Grant 2012-2014). The authors declare that there are no
   conflicts of interest.
CR Barberis C, 1999, DRUG NEWS PERSPECT, V12, P279, DOI 10.1358/dnp.1999.12.5.863621
   Baskerville TA, 2010, CNS NEUROSCI THER, V16, pe92, DOI 10.1111/j.1755-5949.2010.00154.x
   Bielsky IF, 2004, NEUROPSYCHOPHARMACOL, V29, P483, DOI 10.1038/sj.npp.1300360
   BIRKETT SD, 1988, INT J PEPT PROT RES, V32, P565
   Braida D, 2012, PSYCHOPHARMACOLOGY, V220, P319, DOI 10.1007/s00213-011-2482-2
   Brandewiede J, 2005, BEHAV BRAIN RES, V158, P109, DOI 10.1016/j.bbr.2004.08.012
   Carter CS, 2007, BEHAV BRAIN RES, V176, P170, DOI 10.1016/j.bbr.2006.08.025
   Curley JP, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.025.2009
   Chini B, 2007, BIOCHEM SOC T, V35, P737
   Chini B, 2008, PROG BRAIN RES, V170, P513, DOI 10.1016/S0079-6123(08)00438-X
   Crawley J.N, 2000, WHATS WRONG MY MOUSE
   Dauge V, 2001, NEUROPSYCHOPHARMACOL, V25, P690, DOI 10.1016/S0893-133X(01)00291-3
   Deacon RMJ, 2006, NAT PROTOC, V1, P1117, DOI 10.1038/nprot.2006.170
   DeVito LM, 2009, J NEUROSCI, V29, P2676, DOI 10.1523/JNEUROSCI.5488-08.2009
   Eaton JL, 2012, DEV PSYCHOBIOL, V54, P92, DOI 10.1002/dev.20566
   File SE, 1998, BRAIN RES, V805, P234, DOI 10.1016/S0006-8993(98)00736-7
   FISHER E, 1994, NAT GENET, V7, P5, DOI 10.1038/ng0594-5
   Francis DD, 2002, J NEUROENDOCRINOL, V14, P349, DOI 10.1046/j.0007-1331.2002.00776.x
   Franklin K.B.J., 2007, MOUSE BRAIN STEREOTA, V3rd
   Gozzi A, 2010, NEURON, V67, P656, DOI 10.1016/j.neuron.2010.07.008
   Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62
   Huber D, 2005, SCIENCE, V308, P245, DOI 10.1126/science.1105636
   Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
   IRWIN S, 1968, PSYCHOPHARMACOLOGIA, V13, P222, DOI 10.1007/BF00401402
   Jero J, 2001, ACTA OTO-LARYNGOL, V121, P585, DOI 10.1080/000164801316878863
   Jin D, 2007, NATURE, V446, P41, DOI 10.1038/nature05526
   Kalueff AV, 2006, NEUROREPORT, V17, P1347, DOI 10.1097/01.wnr.0000230514.08962.76
   Kuehn BM, 2011, JAMA-J AM MED ASSOC, V305, P659, DOI 10.1001/jama.2011.117
   Lee HJ, 2008, ENDOCRINOLOGY, V149, P3256, DOI 10.1210/en.2007-1710
   Lee HJ, 2009, PROG NEUROBIOL, V88, P127, DOI 10.1016/j.pneurobio.2009.04.001
   LISTER RG, 1987, PSYCHOPHARMACOLOGY, V92, P180
   Liu WS, 2005, NEUROL RES, V27, P339, DOI 10.1179/016164105X35602
   LOWBRIDGE J, 1977, J MED CHEM, V20, P120, DOI 10.1021/jm00211a025
   Macbeth AH, 2009, GENES BRAIN BEHAV, V8, P558, DOI 10.1111/j.1601-183X.2009.00506.x
   Meyer-Lindenberg A, 2011, NAT REV NEUROSCI, V12, P524, DOI 10.1038/nrn3044
   Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
   Phelps SM, 2010, NEUROPHARMACOLOGY, V58, P17, DOI 10.1016/j.neuropharm.2009.06.043
   Popik P, 1996, EUR J PHARMACOL, V308, P113, DOI 10.1016/0014-2999(96)00215-4
   PORSOLT RD, 1977, ARCH INT PHARMACOD T, V229, P327
   Ross HE, 2009, FRONT NEUROENDOCRIN, V30, P534, DOI 10.1016/j.yfrne.2009.05.004
   Rubino T, 2005, J NEUROCHEM, V93, P984, DOI 10.1111/j.1471-4159.2005.03101.x
   Sala M, 2011, BIOL PSYCHIAT, V69, P875, DOI 10.1016/j.biopsych.2010.12.022
   STERU L, 1985, PSYCHOPHARMACOLOGY, V85, P367, DOI 10.1007/BF00428203
   Stevenson EL, 2012, HORM BEHAV, V61, P277, DOI 10.1016/j.yhbeh.2011.11.009
   Takayanagi Y, 2005, P NATL ACAD SCI USA, V102, P16096, DOI 10.1073/pnas.0505312102
   Teixeira CM, 2011, NEUROPSYCHOPHARMACOL, V36, P2395, DOI 10.1038/npp.2011.153
   Tordjman S, 2003, BEHAV GENET, V33, P529, DOI 10.1023/A:1025774716976
   Watanabe Y, 2010, BIOL PHARM BULL, V33, P647
   Winslow JT, 2002, NEUROPEPTIDES, V36, P221, DOI 10.1054/npep.2002.0909
   Yoshida M, 2009, J NEUROSCI, V29, P2259, DOI 10.1523/JNEUROSCI.5593-08.2009
NR 50
TC 10
Z9 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD FEB
PY 2013
VL 25
IS 2
BP 107
EP 118
DI 10.1111/j.1365-2826.2012.02385.x
PG 12
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 078BF
UT WOS:000314072400002
PM 22967062
ER

PT J
AU Domes, G
   Hollerbach, P
   Vohs, K
   Mokros, A
   Habermeyer, E
AF Domes, Gregor
   Hollerbach, Pia
   Vohs, Knut
   Mokros, Andreas
   Habermeyer, Elmar
TI EMOTIONAL EMPATHY AND PSYCHOPATHY IN OFFENDERS: AN EXPERIMENTAL STUDY
SO JOURNAL OF PERSONALITY DISORDERS
LA English
DT Article
ID ANTISOCIAL PERSONALITY-DISORDERS; FACIAL AFFECT RECOGNITION;
   HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; SOCIAL DESIRABILITY; SEXUAL
   OFFENDERS; MIND; DEFICITS; ADULTS; EYES
AB Previous studies associated psychopathy in adults with deficits in empathy but these studies did not directly compare cognitive and emotional facets of empathy. The present study sought to establish whether psychopathy is associated with impairments in emotional empathy among adult offenders. Participants were 90 male offenders scoring low (n = 29), medium (n = 33) or high (n = 28) on the Psychopathy Checklist-Revised (PCL-R) and n = 28 male noncriminal controls. Empathy functioning was assessed through self-report and computerized decision tasks, differentiating between perspective-taking (cognitive empathy) and compassion (emotional empathy). Against expectations, level of psychopathy among the offenders was not associated with either emotional or cognitive empathy. Offenders however had lower scores for both cognitive and emotional components of empathy functioning than controls. Both facets of empathy showed small but significant positive correlations with education level and social desirability. The methods employed to assess differences in empathy functioning may not be sensitive enough to assess differences in forensic samples.
C1 [Domes, Gregor; Hollerbach, Pia] Univ Freiburg, D-79104 Freiburg, Germany.
   [Vohs, Knut; Mokros, Andreas; Habermeyer, Elmar] Psychiat Univ Hosp Zurich, Zurich, Switzerland.
RP Domes, G (reprint author), Univ Freiburg, Lab Biol & Personal Psychol, Dept Psychol, Stefan Meier Str 8, D-79104 Freiburg, Germany.
EM domes@psychologie.uni-freiburg.de
RI Domes, Gregor/J-3369-2013
OI Domes, Gregor/0000-0001-5908-4374
CR Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Birbaumer N, 2005, ARCH GEN PSYCHIAT, V62, P799, DOI 10.1001/archpsyc.62.7.799
   Blair RJR, 2008, Q J EXP PSYCHOL, V61, P157, DOI 10.1080/17470210701508855
   Blair RJR, 2001, J ABNORM CHILD PSYCH, V29, P491, DOI 10.1023/A:1012225108281
   Blair RJR, 1997, PSYCHOPHYSIOLOGY, V34, P192
   Blair RJR, 2005, DEV PSYCHOPATHOL, V17, P865, DOI 10.1017/S0954579405050418
   Blair RJR, 2001, J NEUROL NEUROSUR PS, V71, P727, DOI 10.1136/jnnp.71.6.727
   Blair RJR, 2006, J CHILD PSYCHOL PSYC, V47, P262, DOI 10.1111/j.1469-7610.2006.01596.x
   Book AS, 2007, CRIM JUSTICE BEHAV, V34, P531, DOI 10.1177/0093854806293554
   Borchard B, 2003, PSYCHIAT PRAX, V30, P133, DOI 10.1055/s-2003-38607
   Cleckley H., 1976, MASK SANITY ATTEMPT, V5th
   Coid J, 2010, COMPR PSYCHIAT, V51, P426, DOI 10.1016/j.comppsych.2009.09.006
   Coid J, 2009, INT J LAW PSYCHIAT, V32, P134, DOI 10.1016/j.ijlp.2009.02.008
   Cooke DJ, 2004, J PERS DISORD, V18, P337, DOI 10.1521/pedi.18.4.337.40347
   Cox CL, 2012, SOC COGN AFFECT NEUR, V7, P727, DOI 10.1093/scan/nsr051
   DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
   Dolan M, 2004, PSYCHOL MED, V34, P1093, DOI 10.1017/S0033291704002028
   Dolan M, 2006, PSYCHOL MED, V36, P1563, DOI 10.1017/S0033291706008634
   Domes G, 2007, BIOL PSYCHIAT, V61, P731, DOI 10.1016/j.biopsych.2006.07.015
   Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
   Eisenbarth H, 2008, PSYCHIAT RES, V159, P189, DOI 10.1016/j.psychres.2007.09.001
   Eysenck HJ, 1964, MANUAL EYSENCK PERSO
   Flor H, 2002, PSYCHOPHYSIOLOGY, V39, P505, DOI 10.1017/S0048577202394046
   Glass SJ, 2006, J ABNORM PSYCHOL, V115, P815, DOI 10.1037/0021-843X.115.4.815
   Habermeyer E, 2010, BEHAV SCI LAW, V28, P267, DOI 10.1002/bsl.927
   Hare R. D., 1990, PSYCHOL ASSESSMENT J, V2, P338, DOI 10.1037/1040-3590.2.3.338
   HARE RD, 1971, J ABNORM PSYCHOL, V77, P223, DOI 10.1037/h0031012
   Hare RD, 2003, HARE PSYCHOPATHY CHE
   Hare RD, 2008, ANNU REV CLIN PSYCHO, V4, P217, DOI 10.1146/annurev.clinpsy.3.022806.091452
   Hare RD, 2009, CAN J PSYCHIAT, V54, P791
   HARRIS GT, 1994, J CONSULT CLIN PSYCH, V62, P387, DOI 10.1037/0022-006X.62.2.387
   Hastings ME, 2008, PERS INDIV DIFFER, V44, P1474, DOI 10.1016/j.paid.2008.01.004
   Herpertz SC, 2000, BEHAV SCI LAW, V18, P567, DOI 10.1002/1099-0798(200010)18:5<567::AID-BSL410>3.0.CO;2-8
   Hurlemann R, 2010, J NEUROSCI, V30, P4999, DOI 10.1523/JNEUROSCI.5538-09.2010
   Hysek CM, 2012, PSYCHOPHARMACOLOGY, V222, P293, DOI 10.1007/s00213-012-2645-9
   Jones AP, 2010, J CHILD PSYCHOL PSYC, V51, P1188, DOI 10.1111/j.1469-7610.2010.02280.x
   Kirsch LG, 2007, CLIN PSYCHOL REV, V27, P904, DOI 10.1016/j.cpr.2007.01.011
   Lawrence EJ, 2004, PSYCHOL MED, V34, P911, DOI 10.1017/S0033291703001624
   Leistico AMR, 2008, LAW HUMAN BEHAV, V32, P28, DOI 10.1007/s10979-007-9096-6
   Lishner DA, 2012, INT J OFFENDER THER, V56, P1161, DOI 10.1177/0306624X11421891
   Lykken D. T., 1957, ABNORMAL PSYCHOL, V55, P6
   Malterer MB, 2010, ASSESSMENT, V17, P3, DOI 10.1177/1073191109349743
   Marsh AA, 2008, NEUROSCI BIOBEHAV R, V32, P454, DOI 10.1016/j.neubiorev.2007.08.003
   Mokros A, 2011, LAW HUMAN BEHAV, V35, P188, DOI 10.1007/s10979-010-9221-9
   NEWMAN JP, 1986, J ABNORM PSYCHOL, V95, P252, DOI 10.1037/0021-843X.95.3.252
   Pham TH, 2010, J PERS DISORD, V24, P445, DOI 10.1521/pedi.2010.24.4.445
   Ratschinski G., 1983, EYSENCK PERSONALITY
   Richell RA, 2003, NEUROPSYCHOLOGIA, V41, P523, DOI 10.1016/S0028-3932(02)00175-6
   Rogers K, 2007, J AUTISM DEV DISORD, V37, P709, DOI 10.1007/s10803-006-0197-8
   Schneider K, 1923, HDB PSYCHIAT 1, P69
   Sharp C, 2008, COGNITION EMOTION, V22, P1149, DOI 10.1080/02699930701667586
   Singer T, 2009, ANN NY ACAD SCI, V1156, P81, DOI 10.1111/j.1749-6632.2009.04418.x
   Sommer M, 2006, PROG BRAIN RES, V156, P457, DOI 10.1016/S0079-6123(06)56025-X
   Tan L, 2008, SEX ABUSE-J RES TR, V20, P61, DOI 10.1177/1079063208314820
   Tatman AW, 2009, SEX ABUSE-J RES TR, V21, P21, DOI 10.1177/1079063208325203
   Tewes U., 1991, HAMBURG WECHSLER INT
   Wilson K, 2011, CRIM JUSTICE BEHAV, V38, P659, DOI 10.1177/0093854811404120
   Wittchen HU, 1997, STRUKTURIERTES KLIN
NR 59
TC 13
Z9 13
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0885-579X
J9 J PERS DISORD
JI J. Pers. Disord.
PD FEB
PY 2013
VL 27
IS 1
SI SI
BP 67
EP 84
PG 18
WC Psychiatry
SC Psychiatry
GA 082EX
UT WOS:000314376200006
PM 23342958
ER

PT J
AU Storch, EA
   Arnold, EB
   Lewin, AB
   Nadeau, JM
   Jones, AM
   De Nadai, AS
   Mutch, PJ
   Selles, RR
   Ung, D
   Murphy, TK
AF Storch, Eric A.
   Arnold, Elysse B.
   Lewin, Adam B.
   Nadeau, Josh M.
   Jones, Anna M.
   De Nadai, Alessandro S.
   Mutch, P. Jane
   Selles, Robert R.
   Ung, Danielle
   Murphy, Tanya K.
TI The Effect of Cognitive-Behavioral Therapy Versus Treatment as Usual for
   Anxiety in Children With Autism Spectrum Disorders: A Randomized,
   Controlled Trial
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism spectrum disorders; anxiety; cognitive-behavioral therapy;
   treatment
ID HIGH-FUNCTIONING AUTISM; PERVASIVE DEVELOPMENTAL DISORDERS; SYMPTOMS;
   FAMILY; YOUTH; RELIABILITY; ADOLESCENTS; SKILLS; RATES
AB Objective: To examine the efficacy of a modular cognitive-behavioral therapy (CBT) protocol relative to treatment as usual (TAU) among children with high-functioning autism spectrum disorders (ASD) and clinically significant anxiety Method: A total of 45 children (7-11 years of age) with high-functioning ASD and clinically significant anxiety were randomized to receive 16 sessions of weekly CBT or TAU for an equivalent duration. After screening, assessments were conducted at baseline, post-treatment, and 3-month follow-up. Raters were blind to treatment condition. Results: Youth receiving CBT showed substantial improvement relative to TAU on primary anxiety outcomes. Of 24 children randomized to the CBT arm, 18 (75%) were treatment responders, versus only 3 of 21 children (14%) in the TAU arm. Gains were generally maintained at 3-month follow-up for CBT responders. Conclusions: Relative to usual care, CBT adapted for anxious youth with high-functioning ASD demonstrates large effects in reducing anxiety symptoms. This study contributes to the growing literature supporting adapted CBT approaches for treating anxiety in youth with ASD. Clinical trial registration information Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders; http://clinicaltrials.gov; NCT01178385. J. Am. Acad. Child Adolesc. Psychiatry; 2013;52(2):132-144.
C1 [Storch, Eric A.; Arnold, Elysse B.; Lewin, Adam B.; Nadeau, Josh M.; De Nadai, Alessandro S.; Mutch, P. Jane; Selles, Robert R.; Ung, Danielle; Murphy, Tanya K.] Univ S Florida, St Petersburg, FL 33701 USA.
   [Jones, Anna M.] Univ Georgia, Athens, GA 30602 USA.
RP Storch, EA (reprint author), Univ S Florida, Dept Pediat, Rothman Ctr Neuropsychiat, Box 7523,880 6th St S, St Petersburg, FL 33701 USA.
RI Murphy, Tanya/J-7079-2013; Nadeau, Joshua/F-1462-2015
OI Nadeau, Joshua/0000-0002-9886-4709
FU All Children's Hospital Research Foundation; University of South Florida
   Internal Grants Program; National Institutes of Health (NIH); Centers
   for Disease Control (CDC); Agency for Healthcare Research and Quality;
   National Alliance for Research on Schizophrenia and Affective Disorders
   (NARSAD); International Obsessive-Compulsive Disorder Foundation
   (IOCDF); Tourette Syndrome Association; Janssen Pharmaceuticals; All
   Children's Hospital Guild Endowed Chair; NIH; NARSAD; CDC; IOCDF; Forest
   Laboratories; Shire; Transcept Pharmaceuticals, Inc.; Maurice and Thelma
   Rothman Endowed Chair
FX This work was supported, by grants from the All Children's Hospital
   Research Foundation and the University of South Florida Internal Grants
   Program (E.A.S.)Dr Storch has received grant funding from the National
   Institutes of Health (NIH), Centers for Disease Control (CDC), the
   Agency for Healthcare Research and Quality, the National Alliance for
   Research on Schizophrenia and Affective Disorders (NARSAD), the
   International Obsessive-Compulsive Disorder Foundation (IOCDF), the
   Tourette Syndrome Association, and Janssen Pharmaceuticals. He has
   received textbook honoraria from Springer publishers, the American
   Psychological Association, and Lawrence Erlbaum. He has served as an
   educational consultant for Rogers Memorial Hospital. He has served as a
   consultant for Prophase, Inc., and CroNos, Inc., and has served on the
   speakers' bureau and scientific advisory board for IOCDF. He has
   received research support from the All Children's Hospital Guild Endowed
   Chair. Dr. Lewin has received grant funding from NIH, the Agency for
   Healthcare Research and Quality, CDC, NARSAD, and IOCDF. He has served
   as a consultant for Prophase, Inc. Dr. Murphy has received research
   support from NIH, Forest Laboratories, Janssen Pharmaceuticals, the
   IOCDF, the Tourette Syndrome Association, CDC, Shire, Transcept
   Pharmaceuticals, Inc., and NARSAD. She has served on the Medical
   Advisory Board for the Tourette Syndrome Association and on the
   Scientific Advisory Board for IOCDF. She has received textbook
   honorarium from Lawrence Erlbaum, and research support from the Maurice
   and Thelma Rothman Endowed Chair Dr. Mulch, Ms. Arnold, Mr. Nadeau, Ms.
   Jones, Mr. De Nadai, Mr. Selles, and Ms. Ung report no biomedical,
   financial interests or potential conflicts of interest.
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
   Arnold LE, 2010, J CHILD ADOL PSYCHOP, V20, P83, DOI 10.1089/cap.2009.0022
   Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
   Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x
   Bird HR, 1996, INT J METHOD PSYCH, V6, P295, DOI 10.1002/(SICI)1234-988X(199612)6:4<295::AID-MPR173>3.3.CO;2-5
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Chambless DL, 1998, J CONSULT CLIN PSYCH, V66, P7, DOI 10.1037//0022-006X.66.1.7
   Constantino JN, 2002, SOCIAL RESPONSIVENES
   Creswell C, 2007, CLIN CHILD FAM PSYCH, V10, P232, DOI 10.1007/s10567-007-0019-3
   de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
   Drahota A, 2011, J AUTISM DEV DISORD, V41, P257, DOI 10.1007/s10803-010-1037-4
   Guy W, 1976, CLIN GLOBAL IMPRESSI, P218
   Horwitz SM, 2001, PSYCHIATR SERV, V52, P1088, DOI 10.1176/appi.ps.52.8.1088
   Kelly AB, 2008, J ABNORM CHILD PSYCH, V36, P1069, DOI 10.1007/s10802-008-9234-8
   King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   March J., 1998, MANUAL MULTIDIMENSIO
   Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X
   Myers TA, 2011, COMMUNICATION METHOD, V5, P297, DOI DOI 10.1080/19312458.2011.624490
   Puleo CM, 2011, J AUTISM DEV DISORD, V41, P275, DOI 10.1007/s10803-010-1047-2
   Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
   Reaven J, 2012, J CHILD PSYCHOL PSYC, V53, P410, DOI 10.1111/j.1469-7610.2011.02486.x
   REYNOLDS CR, 1978, J ABNORM CHILD PSYCH, V6, P271, DOI 10.1007/BF00919131
   Rosenberg RE, 2010, J AUTISM DEV DISORD, V40, P342, DOI 10.1007/s10803-009-0878-1
   RUPP, 2002, J AM ACAD CHILD ADOL, V41, P1061
   Silverman W. K., 1996, ANXIETY DISORDERS IN
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Storch EA, 2012, J AUTISM DEV DISORD, V42, P2374, DOI 10.1007/s10803-012-1489-9
   Storch EA, 2012, J CHILD ADOL PSYCHOP, V22, P292, DOI 10.1089/cap.2011.0114
   Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
   Walkup JT, 2008, NEW ENGL J MED, V359, P2753, DOI 10.1056/NEJMoa0804633
   Wood J. J., 2005, BEHAV INTERVENTIONS
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Wood JJ, 2009, J AUTISM DEV DISORD, V39, P1608, DOI 10.1007/s10803-009-0791-7
   Wood JJ, 2006, J AM ACAD CHILD PSY, V45, P314, DOI 10.1097/01.chi.0000196425.88341.b0
NR 37
TC 24
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD FEB
PY 2013
VL 52
IS 2
BP 132
EP 142
DI 10.1016/j.jaac.2012.11.007
PG 11
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 082YN
UT WOS:000314430000005
PM 23357440
ER

PT J
AU Yim, SV
   Kim, SK
   Park, HJ
   Jeon, HS
   Jo, BC
   Kang, WS
   Lee, SM
   Kim, JW
   Chung, JH
AF Yim, Sung-Vin
   Kim, Su Kang
   Park, Hae Jeong
   Jeon, Hye Sook
   Jo, Byung Chul
   Kang, Won Sub
   Lee, Sang Min
   Kim, Jong Woo
   Chung, Joo-Ho
TI Assessment of the correlation between TIMP4 SNPs and schizophrenia and
   autism spectrum disorders
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE tissue inhibitor of metalloproteinase 4; OPCRIT; schizophrenia; autism
   spectrum disorders; single nucleotide polymorphism; Korean
ID CORONARY-ARTERY LESIONS; MATRIX METALLOPROTEINASES; TISSUE INHIBITOR;
   KAWASAKI-DISEASE; POLYMORPHISMS; ASSOCIATION; SUSCEPTIBILITY;
   ABNORMALITIES; EXPRESSION; CANCER
AB Tissue inhibitors of metalloproteinases (TIMPs) are involved in synaptic plasticity, neuronal cell differentiation and neuroprotection in the central nervous system. To investigate whether TIMP4 polymorphisms are associated with schizophrenia and autism spectrum disorders (ASDs), 480 patients (schizophrenia, n=287; ASDs, n=193) and 296 controls were enrolled. Clinical symptoms of schizophrenia and ASDs were assessed using the operation criteria checklist for psychotic illness (OPCRIT) and Childhood Autism Rating Scale (CARS), respectively. One promoter single nucleotide polymorphism (SNP; rs3755724, -55C/T) and one exonic SNP (rs17035945, 3'-untranslated region) were selected. SNPStats and SNPAnalyzer Pro programs were used to calculate odds ratios. Multiple logistic regression models were performed to analyze the genetic data. Based on the results, these two SNPs were not associated with schizophrenia and ASD. In the analysis of clinical features of schizophrenia, rs3755724 was nominally associated with schizophrenia with poor concentration (P=0.044 in the codominant2 model, P=0.041 in the log-additive model and P=0.043 in allele frequency). These results suggest that TIMP4 is not associated with the development of schizophrenia and ASD in the population studied.
C1 [Yim, Sung-Vin] Kyung Hee Univ, Dept Clin Pharmacol, Sch Med, Seoul 130702, South Korea.
   [Kim, Su Kang; Park, Hae Jeong; Jeon, Hye Sook; Jo, Byung Chul; Chung, Joo-Ho] Kyung Hee Univ, Dept Pharmacol, Sch Med, Kohwang Med Res Inst, Seoul 130702, South Korea.
   [Kang, Won Sub; Lee, Sang Min; Kim, Jong Woo] Kyung Hee Univ, Dept Neuropsychiat, Sch Med, Seoul 130702, South Korea.
RP Kim, JW (reprint author), Kyung Hee Univ, Dept Neuropsychiat, Sch Med, 1 Hoegi Dong, Seoul 130702, South Korea.
EM psyjong@gmail.com; jhchung@khu.ac.kr
FU Kyung Hee University [KHU-20071484]
FX This study was supported by a grant from the Kyung Hee University
   (KHU-20071484).
CR Ban JY, 2009, PEDIATR CARDIOL, V30, P331, DOI 10.1007/s00246-008-9341-x
   Berretta S, 2012, NEUROPHARMACOLOGY, V62, P1584, DOI 10.1016/j.neuropharm.2011.08.010
   Bourboulia D, 2010, SEMIN CANCER BIOL, V20, P161, DOI 10.1016/j.semcancer.2010.05.002
   Brown AS, 2011, PROG NEUROBIOL, V93, P23, DOI 10.1016/j.pneurobio.2010.09.003
   Burkhardt J, 2009, J RHEUMATOL, V36, P2149, DOI 10.3899/jrheum.090059
   Candelario-Jalil E, 2009, NEUROSCIENCE, V158, P983, DOI 10.1016/j.neuroscience.2008.06.025
   Cesca F, 2010, PROG NEUROBIOL, V91, P313, DOI 10.1016/j.pneurobio.2010.04.006
   Chang DM, 2002, IMMUNOL INVEST, V31, P1, DOI 10.1081/IMM-120003217
   Chen W, 2010, P NATL ACAD SCI USA, V107, P7401, DOI 10.1073/pnas.0912702107
   Clark IA, 2008, INT J BIOCHEM CELL B, V40, P1362, DOI 10.1016/j.biocel.2007.12.006
   Crocker SJ, 2004, J NEUROSCI RES, V75, P1, DOI 10.1002/jnr.10836
   Dyck BA, 2011, SCHIZOPHR RES, V130, P250, DOI 10.1016/j.schres.2011.05.017
   Fassio A, 2011, HUM MOL GENET, V20, P2297, DOI 10.1093/hmg/ddr122
   Furuno K, 2007, J PEDIATR-US, V151, P155, DOI 10.1016/j.jpeds.2007.03.010
   Gabriel SB, 2002, SCIENCE, V296, P2225, DOI 10.1126/science.1069424
   Garay Paula A, 2010, Front Synaptic Neurosci, V2, P136, DOI 10.3389/fnsyn.2010.00136
   Gomez DE, 1997, EUR J CELL BIOL, V74, P111
   Hegab AE, 2005, RESP MED, V99, P107, DOI 10.1016/j.rmed.2004.05.017
   Kim SK, 2010, MOL CELL TOXICOL, V6, P395, DOI 10.1007/s13273-010-0052-z
   Lambert E, 2004, CRIT REV ONCOL HEMAT, V49, P187, DOI 10.1016/j.critrevonc.2003.09.008
   Leco KJ, 1997, FEBS LETT, V401, P213, DOI 10.1016/S0014-5793(96)01474-3
   Lee Hee Jae, 2005, Behav Brain Funct, V1, P15, DOI 10.1186/1744-9081-1-15
   Lim NKH, 2011, J ALZHEIMERS DIS, V26, P779, DOI 10.3233/JAD-2011-101974
   Lorenzl S, 2003, J NEUROL SCI, V207, P71, DOI 10.1016/S0022-510X(02)00398-2
   Majsterek I, 2011, MED SCI MONITOR, V17, P417
   Melendez-Zajgla J, 2008, MOL CANCER, V7, DOI 10.1186/1476-4598-7-85
   Nakanishi K, 2004, PEDIATR NEPHROL, V19, P144, DOI 10.1007/s00467-003-1350-7
   O-charoenrat P, 2006, ORAL ONCOL, V42, P257, DOI 10.1016/j.oraloncology.2005.07.008
   Ogata T, 2005, J VASC SURG, V41, P1036, DOI 10.1016/j.jvs.2005.02.020
   Peterson NB, 2009, INT J CANCER, V125, P844, DOI 10.1002/ijc.24405
   Pilcher BK, 1999, ANN NY ACAD SCI, V878, P12, DOI 10.1111/j.1749-6632.1999.tb07671.x
   Saviouk V, 2007, SCHIZOPHR RES, V96, P100, DOI 10.1016/j.schres.2007.07.031
   Swarnakar S, 2011, J PINEAL RES, V50, P8, DOI 10.1111/j.1600-079X.2010.00812.x
   Thompson AR, 2008, EUR J VASC ENDOVASC, V35, P19, DOI 10.1016/j.ejvs.2007.07.022
   Valtorta F, 2011, SEMIN CELL DEV BIOL, V22, P378, DOI 10.1016/j.semcdb.2011.07.008
NR 35
TC 1
Z9 1
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
J9 MOL MED REP
JI Mol. Med. Rep.
PD FEB
PY 2013
VL 7
IS 2
BP 489
EP 494
DI 10.3892/mmr.2012.1221
PG 6
WC Oncology; Medicine, Research & Experimental
SC Oncology; Research & Experimental Medicine
GA 073TB
UT WOS:000313764300024
PM 23229788
ER

PT J
AU Krey, JF
   Pasca, SP
   Shcheglovitov, A
   Yazawa, M
   Schwemberger, R
   Rasmusson, R
   Dolmetsch, RE
AF Krey, Jocelyn F.
   Pasca, Sergiu P.
   Shcheglovitov, Aleksandr
   Yazawa, Masayuki
   Schwemberger, Rachel
   Rasmusson, Randall
   Dolmetsch, Ricardo E.
TI Timothy syndrome is associated with activity-dependent dendritic
   retraction in rodent and human neurons
SO NATURE NEUROSCIENCE
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; IPSC-DERIVED NEURONS; CA2+ CHANNEL;
   CALCIUM-CHANNEL; DISTINCT ROLES; KINASE PATHWAY; BETA-SUBUNITS;
   RHO-KINASE; CELL-SHAPE; MUTATIONS
AB L-type voltage gated calcium channels have an important role in neuronal development by promoting dendritic growth and arborization. A point mutation in the gene encoding Ca(V)1.2 causes Timothy syndrome, a neurodevelopmental disorder associated with autism spectrum disorders (ASDs). We report that channels with the Timothy syndrome alteration cause activity-dependent dendrite retraction in rat and mouse neurons and in induced pluripotent stem cell (iPSC)-derived neurons from individuals with Timothy syndrome. Dendrite retraction was independent of calcium permeation through the mutant channel, was associated with ectopic activation of RhoA and was inhibited by overexpression of the channel-associated GTPase Gem. These results suggest that Ca(V)1.2 can activate RhoA signaling independently of Ca2+ and provide insights into the cellular basis of Timothy syndrome and other ASDs.
C1 [Krey, Jocelyn F.; Pasca, Sergiu P.; Shcheglovitov, Aleksandr; Yazawa, Masayuki; Schwemberger, Rachel; Dolmetsch, Ricardo E.] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA.
   [Rasmusson, Randall] SUNY Buffalo, Dept Physiol & Biophys, Buffalo, NY 14260 USA.
   [Dolmetsch, Ricardo E.] Allen Inst Brain Sci, Seattle, WA USA.
RP Dolmetsch, RE (reprint author), Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA.
EM ricardo.dolmetsch@stanford.edu
FU National Institutes of Health under Ruth L. Kirschstein National
   Research Service Award from the National Institute of Neurological
   Disorders and Stroke [F31 NS055549-03]; US National Institutes of
   Health; Simons Foundation; International Brain Research Organization;
   Tashia and John Morgridge Endowed Fellowship; Japan Society of the
   Promotion for Science; American Heart Association; California Institute
   for Regenerative Medicine Postdoctoral Fellowship
FX We thank K. Timothy and the individuals with Timothy syndrome who
   participated in this study, J. Bernstein and J. Hallmayer for recruiting
   the subjects for this study, and E. Nigh for critical reading of the
   manuscript. J.F.K. was supported by the National Institutes of Health
   under Ruth L. Kirschstein National Research Service Award (F31
   NS055549-03) from the National Institute of Neurological Disorders and
   Stroke. Financial support was provided by a US National Institutes of
   Health Director's Pioneer Award and a Simons Foundation Grant to R.E.D.;
   the International Brain Research Organization Outstanding Research
   Fellowship and the Tashia and John Morgridge Endowed Fellowship to
   S.P.P.; a Japan Society of the Promotion for Science Postdoctoral
   Fellowship for Research Abroad and American Heart Association Western
   States to MY.; and a California Institute for Regenerative Medicine
   Postdoctoral Fellowship to O.S. We are grateful for funding from B. and
   F. Horowitz, M. McCafferey, B. and J. Packard, P. Kwan and K. Wang.
CR Aizawa H, 2004, SCIENCE, V303, P197, DOI 10.1126/science.1089845
   Aresta S, 2002, BIOCHEM J, V367, P57, DOI 10.1042/BJ20020829
   Bader PL, 2011, P NATL ACAD SCI USA, V108, P15432, DOI 10.1073/pnas.1112667108
   Barrett CF, 2008, P NATL ACAD SCI USA, V105, P2157, DOI 10.1073/pnas.0710501105
   Beguin P, 2001, NATURE, V411, P701, DOI 10.1038/35079621
   Beguin P, 2005, J CELL SCI, V118, P1923, DOI 10.1242/jcs.02321
   Beguin P, 2007, J BIOL CHEM, V282, P11509, DOI 10.1074/jbc.M606423200
   Belmonte MK, 2006, NAT NEUROSCI, V9, P1221, DOI 10.1038/nn1765
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5
   Catterall WA, 2000, ANNU REV CELL DEV BI, V16, P521, DOI 10.1146/annurev.cellbio.16.1.521
   Cohen-Kutner M, 2010, CHANNELS, V4, P266, DOI 10.4161/chan.4.4.12130
   Dolmetsch R, 2011, CELL, V145, P831, DOI 10.1016/j.cell.2011.05.034
   Dolmetsch R, 2003, SCI STKE, V166, ppe4
   Dolmetsch RE, 2001, SCIENCE, V294, P333, DOI 10.1126/science.1063395
   Fink CC, 2003, NEURON, V39, P283, DOI 10.1016/S0896-6273(03)00428-8
   Finlin BS, 2006, J BIOL CHEM, V281, P23557, DOI 10.1074/jbc.M604867200
   Finlin BS, 2005, J BIOL CHEM, V280, P41864, DOI 10.1074/jbc.M414261200
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   HELL JW, 1993, J CELL BIOL, V123, P949, DOI 10.1083/jcb.123.4.949
   Hoda JC, 2006, J NEUROCHEM, V96, P1648, DOI 10.1111/j.1471-4159.2006.03678.x
   Kaufmann WE, 2000, CEREB CORTEX, V10, P981, DOI 10.1093/cercor/10.10.981
   Kranenburg, 1999, MOL BIOL CELL, V10, P1851
   Lee TM, 2000, NEURON, V25, P307, DOI 10.1016/S0896-6273(00)80896-X
   Lohmann C, 2002, NATURE, V418, P177, DOI 10.1038/nature00850
   Lohmann C, 2005, CELL CALCIUM, V37, P403, DOI 10.1016/j.ceca.2005.01.008
   Mahalakshmi RN, 2007, TRAFFIC, V8, P1164, DOI 10.1111/j.1600-0854.2007.00599.x
   McAllister AK, 1996, NEURON, V17, P1057, DOI 10.1016/S0896-6273(00)80239-1
   Nyegaard M, 2010, MOL PSYCHIATR, V15, P119, DOI 10.1038/mp.2009.69
   Oyama F, 2004, J BIOL CHEM, V279, P27272, DOI 10.1074/jbc.M401634200
   Parent L, 1995, BIOPHYS J, V69, P1801
   Pasca SP, 2011, NAT MED, V17, P1657, DOI 10.1038/nm.2576
   Pravettoni E, 2000, DEV BIOL, V227, P581, DOI 10.1006/dbio.2000.9872
   Redmond L, 2002, NEURON, V34, P999, DOI 10.1016/S0896-6273(02)00737-7
   Richards MW, 2004, TRENDS PHARMACOL SCI, V25, P626, DOI 10.1016/j.tips.2004.10.008
   Splawski I, 2005, P NATL ACAD SCI USA, V102, P8089, DOI 10.1073/pnas.0502506102
   Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
   Splawski I, 2006, J BIOL CHEM, V281, P22085, DOI 10.1074/jbc.M603316200
   Swetman CA, 2002, EUR J IMMUNOL, V32, P2074, DOI 10.1002/1521-4141(200207)32:7<2074::AID-IMMU2074>3.0.CO;2-S
   Takahashi K, 2006, CELL, V126, P663, DOI 10.1016/j.cell.2006.07.024
   TANABE T, 1990, NATURE, V346, P567, DOI 10.1038/346567a0
   Tonelli A, 2006, J NEUROL SCI, V241, P13, DOI 10.1016/j.jns.2005.10.007
   Totsukawa G, 2000, J CELL BIOL, V150, P797, DOI 10.1083/jcb.150.4.797
   Tottene A, 2002, P NATL ACAD SCI USA, V99, P13284, DOI 10.1073/pnas.192242399
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Ward Y, 2002, J CELL BIOL, V157, P291, DOI 10.1083/jcb.200111026
   Wiser O, 1999, P NATL ACAD SCI USA, V96, P248, DOI 10.1073/pnas.96.1.248
   Wong ROL, 2002, NAT REV NEUROSCI, V3, P803, DOI 10.1038/nrn941
   YANG J, 1993, NATURE, V366, P158, DOI 10.1038/366158a0
   Yazawa M, 2011, NATURE, V471, P230, DOI 10.1038/nature09855
NR 50
TC 39
Z9 40
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1097-6256
J9 NAT NEUROSCI
JI Nat. Neurosci.
PD FEB
PY 2013
VL 16
IS 2
BP 201
EP 209
DI 10.1038/nn.3307
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 080RE
UT WOS:000314260200017
PM 23313911
ER

PT J
AU Chang, SWC
   Gariepy, JF
   Platt, ML
AF Chang, Steve W. C.
   Gariepy, Jean-Francois
   Platt, Michael L.
TI Neuronal reference frames for social decisions in primate frontal cortex
SO NATURE NEUROSCIENCE
LA English
DT Article
ID ANTERIOR CINGULATE CORTEX; MEDIAL PREFRONTAL CORTEX; ORBITOFRONTAL
   CORTEX; VENTRAL STRIATUM; NEURAL BASIS; CHARITABLE DONATION; VALUE
   COMPUTATIONS; REWARD; COGNITION; BEHAVIOR
AB Social decisions are crucial for the success of individuals and the groups that they comprise. Group members respond vicariously to benefits obtained by others, and impairments in this capacity contribute to neuropsychiatric disorders such as autism and sociopathy. We examined the manner in which neurons in three frontal cortical areas encoded the outcomes of social decisions as monkeys performed a reward-allocation task. Neurons in the orbitofrontal cortex (OFC) predominantly encoded rewards that were delivered to oneself. Neurons in the anterior cingulate gyrus (ACCg) encoded reward allocations to the other monkey, to oneself or to both. Neurons in the anterior cingulate sulcus (ACCs) signaled reward allocations to the other monkey or to no one. In this network of received (OFC) and foregone (ACCs) reward signaling, ACCg emerged as an important nexus for the computation of shared experience and social reward. Individual and species-specific variations in social decision-making might result from the relative activation and influence of these areas.
C1 [Chang, Steve W. C.; Platt, Michael L.] Duke Univ, Sch Med, Dept Neurobiol, Durham, NC 27708 USA.
   [Chang, Steve W. C.; Gariepy, Jean-Francois; Platt, Michael L.] Duke Univ, Ctr Cognit Neurosci, Durham, NC USA.
   [Platt, Michael L.] Duke Univ, Dept Psychol & Neurosci, Duke Inst Brain Sci, Durham, NC USA.
   [Platt, Michael L.] Duke Univ, Dept Evolutionary Anthropol, Duke Inst Brain Sci, Durham, NC USA.
RP Chang, SWC (reprint author), Duke Univ, Sch Med, Dept Neurobiol, Durham, NC 27708 USA.
EM steve.chang@duke.edu
FU T32 Postdoctoral Training Grant on Fundamental and Translational
   Neuroscience [2T32NS051156-06]; Ruth K. Broad Biomedical Foundation
   Postdoctoral Grant; Canadian Institutes of Health Research Doctoral
   research award [84765]; National Institute of Mental Health [MH095894];
   Department of Defense [W81XVVH-11-1-0584]
FX We thank J.M. Groh, J.M. Pearson, D.L. Barack, R.B. Ebitz, E.S.
   Bromberg-Martin, K.K. Watson and B.Y. Hayden for helpful discussions. We
   are very grateful to S.P. Wise and C. Padoa-Schioppa for insightful
   discussions and comments on earlier versions of the manuscript. We also
   thank M.L. Carlson for general technical assistance. This work was
   supported by a T32 Postdoctoral Training Grant on Fundamental and
   Translational Neuroscience (S.W.C.C., 2T32NS051156-06), a Ruth K. Broad
   Biomedical Foundation Postdoctoral Grant (S.W.C.C.), a Canadian
   Institutes of Health Research Doctoral research award (J.-F.G., 84765),
   the National Institute of Mental Health (M.L.P. and S.W.C.C., MH095894)
   and the Department of Defense (M.L.P. and S.W.C.C., W81XVVH-11-1-0584).
CR Abe H, 2011, NEURON, V70, P731, DOI 10.1016/j.neuron.2011.03.026
   Adolphs R, 2003, NAT REV NEUROSCI, V4, P165, DOI 10.1038/nrn1056
   Alexander WH, 2011, NAT NEUROSCI, V14, P1338, DOI 10.1038/nn.2921
   Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
   Azzi JCB, 2012, P NATL ACAD SCI USA, V109, P2126, DOI 10.1073/pnas.1111715109
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Behrens TEJ, 2009, SCIENCE, V324, P1160, DOI 10.1126/science.1169694
   BERGER SM, 1962, PSYCHOL REV, V69, P450, DOI 10.1037/h0046466
   Bowman EM, 1996, J NEUROPHYSIOL, V75, P1061
   Burke CJ, 2010, P NATL ACAD SCI USA, V107, P14431, DOI 10.1073/pnas.1003111107
   Carter CS, 1998, SCIENCE, V280, P747, DOI 10.1126/science.280.5364.747
   Chang SWC, 2011, FRONT NEUROSCI-SWITZ, V5, DOI 10.3389/fnins.2011.00027
   Chang SWC, 2012, P NATL ACAD SCI USA, V109, P959, DOI 10.1073/pnas.1114621109
   Cohen YE, 2002, NAT REV NEUROSCI, V3, P553, DOI 10.1038/nrn873
   de Quervain DJF, 2004, SCIENCE, V305, P1254, DOI 10.1126/science.1100735
   Fehr E, 2003, NATURE, V425, P785, DOI 10.1038/nature02043
   Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
   Gold JI, 2007, ANNU REV NEUROSCI, V30, P535, DOI 10.1146/annurev.neuro.29.051605.113038
   Hampton AN, 2008, P NATL ACAD SCI USA, V105, P6741, DOI 10.1073/pnas.0711099105
   Harbaugh WT, 2007, SCIENCE, V316, P1622, DOI 10.1126/science.1140738
   Hare TA, 2010, J NEUROSCI, V30, P583, DOI 10.1523/JNEUROSCI.4089-09.2010
   Hayden BY, 2009, SCIENCE, V324, P948, DOI 10.1126/science.1168488
   Ito S, 2003, SCIENCE, V302, P120, DOI 10.1126/science.1087847
   Izuma K, 2010, J COGNITIVE NEUROSCI, V22, P621, DOI 10.1162/jocn.2009.21228
   Jeon D, 2010, NAT NEUROSCI, V13, P482, DOI 10.1038/nn.2504
   Kennerley SW, 2011, NAT NEUROSCI, V14, P1581, DOI 10.1038/nn.2961
   Kennerley SW, 2006, NAT NEUROSCI, V9, P940, DOI 10.1038/nn1724
   Kuss K, 2013, SOC COGN AFFECT NEUR, V8, P216, DOI 10.1093/scan/nsr088
   Matsumoto M, 2009, NAT NEUROSCI, V12, P77, DOI 10.1038/nn.2233
   Mobbs D, 2009, SCIENCE, V324, P900, DOI 10.1126/science.1170539
   Moll J, 2006, P NATL ACAD SCI USA, V103, P15623, DOI 10.1073/pnas.0604475103
   O'Doherty J, 2004, SCIENCE, V304, P452, DOI 10.1126/science.1094285
   Padoa-Schioppa C, 2006, NATURE, V441, P223, DOI 10.1038/nature04676
   Paton JJ, 2006, NATURE, V439, P865, DOI 10.1038/nature04490
   Paxinos G, 1999, RHESUS MONKEY BRAIN
   Rilling JK, 2002, NEURON, V35, P395, DOI 10.1016/S0896-6273(02)00755-9
   Rudebeck PH, 2006, SCIENCE, V313, P1310, DOI 10.1126/science.1128197
   Santos GS, 2012, SOC NEUROSCI-UK, V7, P42, DOI 10.1080/17470919.2011.578465
   Sato M, 2002, J NEUROSCI, V22, P2363
   Saxe R, 2006, CURR OPIN NEUROBIOL, V16, P235, DOI 10.1016/j.conb.2006.03.001
   Schoenbaum G, 2009, NAT REV NEUROSCI, V10, P885, DOI 10.1038/nrn2753
   Schultz W, 1997, SCIENCE, V275, P1593, DOI 10.1126/science.275.5306.1593
   Seo H, 2008, PHILOS T R SOC B, V363, P3845, DOI 10.1098/rstb.2008.0158
   Shidara M, 1998, J NEUROSCI, V18, P2613
   Singer T, 2004, SCIENCE, V303, P1157, DOI 10.1126/science.1093535
   Sohn J, 2006, NEURAL NETWORKS, V19, P1181, DOI 10.1016/j.neunet.2006.04.005
   Tremblay L, 1999, NATURE, V398, P704
   Tsujimoto S, 2009, J NEUROSCI, V29, P2569, DOI 10.1523/JNEUROSCI.5777-08.2009
   Waytz A, 2012, J NEUROSCI, V32, P7646, DOI 10.1523/JNEUROSCI.6193-11.2012
   Yoshida K, 2011, CURR BIOL, V21, P249, DOI 10.1016/j.cub.2011.01.004
NR 50
TC 44
Z9 46
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1097-6256
J9 NAT NEUROSCI
JI Nat. Neurosci.
PD FEB
PY 2013
VL 16
IS 2
BP 243
EP 250
DI 10.1038/nn.3287
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA 080RE
UT WOS:000314260200022
PM 23263442
ER

PT J
AU Lucht, MJ
   Barnow, S
   Sonnenfeld, C
   Ulrich, I
   Grabe, HJ
   Schroder, W
   Volzke, H
   Freyberger, HJ
   John, U
   Herrmann, FH
   Kroemer, H
   Rosskopf, D
AF Lucht, Michael J.
   Barnow, Sven
   Sonnenfeld, Christine
   Ulrich, Ines
   Grabe, Hans Joergen
   Schroeder, Winnie
   Voelzke, Henry
   Freyberger, Harald J.
   John, Ulrich
   Herrmann, Falko H.
   Kroemer, Heyo
   Rosskopf, Dieter
TI Associations between the oxytocin receptor gene (OXTR) and
   "mind-reading" in humans-An exploratory study
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Association study; Mind-reading; OXTR; Oxytocin
ID ASPERGER-SYNDROME; CANDIDATE GENES; SEX-DIFFERENCES; AUTISM; BEHAVIOR;
   EMPATHY; INTELLIGENCE; POLYMORPHISM; VASOPRESSIN; EXPRESSION
AB Lucht MJ, Barnow S, Sonnenfeld C, Ulrich I, Grabe HJ, Schroeder W, Volzke H, Freyberger, John U, Herrmann FH, Kroemer H, Rosskopf D. Associations between the oxytocin receptor gene (OXTR) and "mind-reading" in humans-An exploratory study. Nord J Psychiatry 2013;67:15-21. Background/aims: The application of intranasal oxytocin enhances facial emotion recognition in normal subjects and in subjects with autism spectrum disorders (ASD). In addition, various features of social cognition have been associated with variants of the oxytocin receptor gene (OXTR). Therefore, we tested for associations between mind-reading, a measure for social recognition and OXTR polymorphisms. Methods: 76 healthy adolescents and young adults were tested for associations between OXTR rs53576, rs2254298, rs2228485 and mind-reading using the "Reading the Mind in the Eyes Test" (RMET). Results: After Bonferroni correction for multiple comparisons, rs2228485 was associated with the number of incorrect answers when subjects evaluated male faces (P = 0.000639). There were also associations between OXTR rs53576, rs2254298 and rs2228485 and other RMET dimensions according to P < 0.05 (uncorrected). Conclusion: This study adds further evidence to the hypothesis that genetic variations in the OXTR modulate mind-reading and social behaviour.
C1 [Lucht, Michael J.] Ernst Moritz Arndt Univ Greifswald, Hosp Psychiat & Psychotherapy, HELIOS Hanseklinikum Stralsund, D-18437 Stralsund, Germany.
   [Barnow, Sven; Ulrich, Ines] Heidelberg Univ, Inst Psychol, Dept Clin Psychol, Heidelberg, Germany.
   [Sonnenfeld, Christine; Kroemer, Heyo; Rosskopf, Dieter] Ernst Moritz Arndt Univ Greifswald, Inst Pharmacol, D-18437 Stralsund, Germany.
   [Grabe, Hans Joergen; Freyberger, Harald J.] Ernst Moritz Arndt Univ Greifswald, Dept Psychiat & Psychotherapy, D-18437 Stralsund, Germany.
   [Schroeder, Winnie; Herrmann, Falko H.] Ernst Moritz Arndt Univ Greifswald, Inst Human Genet, D-18437 Stralsund, Germany.
   [Voelzke, Henry] Ernst Moritz Arndt Univ Greifswald, Inst Community Med, D-18437 Stralsund, Germany.
   [John, Ulrich] Ernst Moritz Arndt Univ Greifswald, Inst Epidemiol & Social Med, D-18437 Stralsund, Germany.
RP Lucht, MJ (reprint author), Ernst Moritz Arndt Univ Greifswald, Hosp Psychiat & Psychotherapy, HELIOS Hanseklinikum Stralsund, Rostocker Chaussee 70, D-18437 Stralsund, Germany.
EM lucht@uni-greifswald.de
FU Federal Ministry of Education and Research [ZZ9603]; Ministry of
   Cultural affairs; Social Ministry of the Federal State of
   Mecklenburg-West Pomerania
FX This work is part of the Community Medicine research net (CMR) of the
   University of Greifswald, Germany, which is funded by the Federal
   Ministry of Education and Research (grant ZZ9603), the Ministry of
   Cultural affairs and the Social Ministry of the Federal State of
   Mecklenburg-West Pomerania.
CR Algovik M, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-105
   Apicella CL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011153
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Carter CS, 2007, BEHAV BRAIN RES, V176, P170, DOI 10.1016/j.bbr.2006.08.025
   Chakrabarti B, 2009, AUTISM RES, V2, P157, DOI 10.1002/aur.80
   Chamary JV, 2006, NAT REV GENET, V7, P98, DOI 10.1038/nrg1770
   Costa B, 2009, PSYCHONEUROENDOCRINO, V34, P1506, DOI 10.1016/j.psyneuen.2009.05.006
   Domes G, 2007, BIOL PSYCHIAT, V61, P731, DOI 10.1016/j.biopsych.2006.07.015
   Domes G, 2010, PSYCHONEUROENDOCRINO, V35, P83, DOI 10.1016/j.psyneuen.2009.06.016
   Freeman B, 1997, BEHAV GENET, V27, P251, DOI 10.1023/A:1025614231190
   Gillath O, 2008, PERS SOC PSYCHOL B, V34, P1396, DOI [10.1177/0146167208321484, 10.1177/1046167208321484]
   Gimpl G, 2001, PHYSIOL REV, V81, P629
   Grabe HJ, 2005, MOL PSYCHIATR, V10, P220, DOI 10.1038/sj.mp.4001555
   Guastella AJ, 2009, BIOL PSYCHIAT, V65, P728
   Hershberg R, 2008, ANNU REV GENET, V42, P287, DOI 10.1146/annurev.genet.42.110807.091442
   Israel S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005535
   Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
   John U, 2001, SOZ PRAVENTIV MED, V46, P186, DOI 10.1007/BF01324255
   Kelemenova S, 2010, PSYCHIAT GENET, V20, P137, DOI 10.1097/YPG.0b013e32833a1eb3
   Kim HS, 2010, P NATL ACAD SCI USA, V107, P15717, DOI 10.1073/pnas.1010830107
   Kogan A, 2011, P NATL ACAD SCI USA, V108, P19189, DOI 10.1073/pnas.1112658108
   LANDER ES, 1994, SCIENCE, V265, P2037, DOI 10.1126/science.8091226
   Lerer E, 2007, MOL PSYCHIAT
   Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087
   Lewin C, 2002, BRAIN COGNITION, V50, P121, DOI 10.1016/S0278-2626(02)00016-7
   Lin PI, 2007, AM J HUM GENET, V80, P531, DOI 10.1086/512133
   Lucht M, 2007, NEUROPSYCHOBIOLOGY, V56, P24, DOI 10.1159/000109974
   Lucht MJ, 2009, PROG NEURO-PSYCHOPH, V33, P860, DOI 10.1016/j.pnpbp.2009.04.004
   MILLER SA, 1988, NUCLEIC ACIDS RES, V16, P1215, DOI 10.1093/nar/16.3.1215
   Mizumoto Y, 1997, MOL CELL ENDOCRINOL, V135, P129, DOI 10.1016/S0303-7207(97)00195-0
   Park J, 2010, PROG NEURO-PSYCHOPH, V34, P697, DOI 10.1016/j.pnpbp.2010.03.029
   PICKLES A, 1995, AM J HUM GENET, V57, P717
   Rajkumar AP, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-51
   Rodrigues SM, 2009, P NATL ACAD SCI USA, V106, P21437, DOI 10.1073/pnas.0909579106
   Sun Y, 2010, BRAIN RES
   Tewes U, 1985, HAMBURG WECHSLER INT
   Tewes U., 1991, HAWIE R HAMBURG WECH
   Thompson RR, 2006, P NATL ACAD SCI USA, V103, P7889, DOI 10.1073/pnas.0600406103
   Tost H, 2010, P NATL ACAD SCI USA, V107, P13936, DOI 10.1073/pnas.1003296107
   Uhl-Bronner S, 2005, NEUROSCIENCE, V135, P147, DOI 10.1016/j.neuroscience.2005.05.025
   van Honka J, 2011, P NATL ACAD SCI USA, V108, P3448, DOI 10.1073/pnas.1011891108
   White S, 2006, BRAIN COGNITION, V61, P69, DOI 10.1016/j.bande.2005.12.007
   Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
   Yrigollen CM, 2008, BIOL PSYCHIAT, V63, P911, DOI 10.1016/j.biopsych.2007.11.015
NR 44
TC 10
Z9 11
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0803-9488
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD FEB
PY 2013
VL 67
IS 1
BP 15
EP 21
DI 10.3109/08039488.2012.700731
PG 7
WC Psychiatry
SC Psychiatry
GA 077YW
UT WOS:000314066300004
PM 22809402
ER

PT J
AU Treasure, J
AF Treasure, Janet
TI Coherence and other autistic spectrum traits and eating disorders:
   Building from mechanism to treatment. The Birgit Olsson lecture
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Anorexia nervosa; Asperger; Autism; Autism spectrum disorder; Bulimia
   nervosa; Eating disorder
ID RECOVERED ANOREXIA-NERVOSA; EXECUTIVE FUNCTIONS; ASPERGER-SYNDROME;
   BULIMIA-NERVOSA; RISK-FACTORS; CASE-SERIES; ONSET; MIND; ENDOPHENOTYPES;
   PERSONALITY
AB Treasure J. Coherence and other autistic spectrum traits and eating disorders: Building from mechanism to treatment. The Birgit Olsson lecture. Nord J Psychiatry 2013;67:38-42. Aim: To revisit Gillberg's hypothesis proposed in 1992, which was that anorexia nervosa should be considered within the spectrum of autistic disorders. Method: A search was made of the literature relating to the behavioural traits, and cognitive, emotional and neuroanatomical intermediate phenotypes that are shared between autistic spectrum disorders (ASD) and anorexia nervosa. Results: People with eating disorders in the acute phase (less so after recovery) share some behavioural traits (social impairment and restricted and repetitive behaviours) and intermediate phenotypes (weak central coherence, and impaired set shifting and theory of mind) with people in the autistic spectrum. Conclusion: Behavioural and intermediate neuropsychological traits are shared between eating disorders and ASD. In part, these are familial but also they are accentuated by the illness state and may be secondary to starvation. These traits have implications for prognosis and treatment.
C1 Kings Coll London, Inst Psychiat, Dept Acad Psychiat, London SE5 7 ND, England.
RP Treasure, J (reprint author), Kings Coll London, Inst Psychiat, Dept Acad Psychiat, PO54,Denmark Hill, London SE5 7 ND, England.
EM Janet.Treasure@kcl.ac.uk
FU National Institute for Health Research (NIHR) under its Research for
   Patient Benefit (RfPB) Programme [PB-PG-0609-19025]
FX This review presents independent research funded by the National
   Institute for Health Research (NIHR) under its Research for Patient
   Benefit (RfPB) Programme (Grant Reference Number PB-PG-0609-19025). The
   views expressed are those of the author and not necessarily those of the
   NHS, the NIHR or the Department of Health.
CR Aldao A, 2010, CLIN PSYCHOL REV, V30, P217, DOI 10.1016/j.cpr.2009.11.004
   Anderluh MB, 2003, AM J PSYCHIAT, V160, P242, DOI 10.1176/appi.ajp.160.2.242
   Cardi V., 2012, WORLD J BIO IN PRESS
   Castro L, 2010, AUST NZ J PSYCHIAT, V44, P1118, DOI 10.3109/00048674.2010.524625
   COMINGS DE, 1991, AM J MED GENET, V39, P180, DOI 10.1002/ajmg.1320390213
   Coombs E, 2011, BRIT J CLIN PSYCHOL, V50, P326, DOI 10.1348/014466510X524408
   Davies H, 2010, INT J EAT DISORDER, V44, P531
   Eddy KT, 2007, INT J EAT DISORDER, V40, pS67, DOI 10.1002/eat.20422
   Fairburn CG, 1999, ARCH GEN PSYCHIAT, V56, P468, DOI 10.1001/archpsyc.56.5.468
   Fisman S, 1996, J AM ACAD CHILD PSY, V35, P937, DOI 10.1097/00004583-199607000-00021
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   GILLBERG C, 1992, BEHAV NEUROL, V5, P27, DOI 10.3233/BEN-1992-5105
   GILLBERG C, 1983, BRIT J PSYCHIAT, V142, P428
   GILLBERG CL, 1992, J CHILD PSYCHOL PSYC, V33, P813, DOI 10.1111/j.1469-7610.1992.tb01959.x
   Gillberg IC, 2010, J CLIN EXP NEUROPSYC, V32, P358, DOI 10.1080/13803390903066857
   Gillberg IC, 2007, J CLIN EXP NEUROPSYC, V29, P170, DOI 10.1080/13803390600584632
   Hambrook D, 2008, BRIT J CLIN PSYCHOL, V47, P335, DOI 10.1348/014466507X272475
   Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Harrison A., 2010, PSYCHOL MED, V40, P1
   Harrison A, 2010, BIOL PSYCHIAT, V68, P755, DOI 10.1016/j.biopsych.2010.04.037
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hill EL, 2006, NEUROPSYCHOLOGIA, V44, P2822, DOI 10.1016/j.neuropsychologia.2006.06.007
   Jacobi C, 2004, PSYCHOL BULL, V130, P19, DOI 10.1037/0033-2909.130.1.19
   Kalyva E, 2009, J AUTISM DEV DISORD, V39, P480, DOI 10.1007/s10803-008-0648-5
   Kanakan N, 2012, THESIS U LONDON
   Kim YR, 2009, INT J EAT DISORDER, V43, P598
   Kopp S, 2012, RES DEV DISABIL, V32, P2875
   Krug I, 2012, J HEALTH PSYCHOL, V18, P26
   Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
   Lilenfeld LR, 1998, ARCH GEN PSYCHIAT, V55, P603, DOI 10.1001/archpsyc.55.7.603
   Lopez C, 2008, PSYCHOL MED, V30, P1
   Lopez C, 2008, J CLIN EXPT NEUROPSY, V31, P117
   Lopez C, 2008, EUR EAT DISORD REV, V16, P411, DOI 10.1002/erv.866
   McAdams CJ, 2011, PSYCHIAT RES-NEUROIM, V194, P54, DOI 10.1016/j.pscychresns.2011.06.016
   Milos G, 2005, BRIT J PSYCHIAT, V187, P573, DOI 10.1192/bjp.187.6.573
   Nakazato M, 2009, PSYCHOL MED, V39, P1029, DOI 10.1017/S0033291708004108
   Odent M, 2010, MED HYPOTHESES, V75, P79, DOI 10.1016/j.mehy.2010.01.039
   Oldershaw A, 2010, PSYCHOSOM MED, V72, P73, DOI 10.1097/PSY.0b013e3181c6c7ca
   Oldershaw A, 2012, EUR EAT DISORD REV, V19, P462
   Oldershaw A., 2010, NEUROSCI BIOBEHAV R, V35, P970
   Roberts ME, 2011, J PSYCHIATR RES, V44, P964
   Roberts ME, 2012, WORLD J BIO IN PRESS
   Roberts ME, 2007, PSYCHOL MED, V37, P1075, DOI 10.1017/S0033291707009877
   Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119
   Robinson EB, 2012, BEHAV GENET, V42, P245, DOI 10.1007/s10519-011-9500-3
   ROTHERY DJ, 1988, BRIT J PSYCHIAT, V153, P714, DOI 10.1192/bjp.153.5.714
   STIVER RL, 1980, J AUTISM DEV DISORD, V10, P67, DOI 10.1007/BF02408434
   Tchanturia K, 2004, EUR EAT DISORD REV, V12, P361, DOI 10.1002/erv.608
   Tchanturia K, 2008, PSYCHOL MED, V38, P1371, DOI 10.1017/S0033291708003796
   Tchanturia K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020462
   Tenconi E, 2010, WORLD J BIOL PSYCHIA, V11, P813, DOI 10.3109/15622975.2010.483250
   Treasure J, 2012, EUR EAT DISORD REV, V20, pe17, DOI 10.1002/erv.1075
   Van den EF, 2009, CHILD ADOL PSYCH CL, V18, P95
   Walsh BT, 2009, INT J EAT DISORD, V31
   Watson KK, 2010, FRONT PSYCHOL, V1, P1
   Wentz E, 2009, BRIT J PSYCHIAT, V194, P168, DOI 10.1192/bjp.bp.107.048686
   Wentz E, 2005, EUR CHILD ADOLES PSY, V14, P431, DOI 10.1007/s00787-005-0494-3
   Whitaker W, 2010, CLIN GUIDE COLLABORA, P174
   Whitney J, 2012, EUR EAT DISORD REV, V20, P142, DOI 10.1002/erv.1076
   Woodside DB, 2002, INT J EAT DISORDER, V31, P290, DOI 10.1002/eat.10032
   Zucker NL, 2007, PSYCHOL BULL, V133, P976, DOI 10.1037/0033-2909.133.6.976
NR 63
TC 6
Z9 6
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0803-9488
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD FEB
PY 2013
VL 67
IS 1
BP 38
EP 42
DI 10.3109/08039488.2012.674554
PG 5
WC Psychiatry
SC Psychiatry
GA 077YW
UT WOS:000314066300007
PM 22468644
ER

PT J
AU Weisenfeld, NI
   Peters, JM
   Tsai, PT
   Prabhu, SP
   Dies, KA
   Sahin, M
   Warfield, SK
AF Weisenfeld, Neil I.
   Peters, Jurriaan M.
   Tsai, Peter T.
   Prabhu, Sanjay P.
   Dies, Kira A.
   Sahin, Mustafa
   Warfield, Simon K.
TI A Magnetic Resonance Imaging Study of Cerebellar Volume in Tuberous
   Sclerosis Complex
SO PEDIATRIC NEUROLOGY
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; CONSENSUS CONFERENCE; MUTATIONAL ANALYSIS;
   TSC1; PERFORMANCE; SEGMENTATION; PHENOTYPE; CHILDREN; ABNORMALITIES;
   VALIDATION
AB The cerebellum plays an important role in motor learning and cognition, and structural cerebellar abnormalities have been associated with cognitive impairment. In tuberous sclerosis complex, neurologic outcome is highly variable, and no consistent imaging or pathologic determinant of cognition has been firmly established. The cerebellum calls for specific attention because mouse models of tuberous sclerosis complex have demonstrated a loss of cerebellar Purkinje cells, and cases of human histologic data have demonstrated a similar loss in patients. We hypothesized that there might be a common cerebellar finding in tuberous sclerosis complex that could be measured as morphometric changes with magnetic resonance imaging. Using a robust, automated image analysis procedure, we studied 36 patients with tuberous sclerosis complex and age-matched control subjects and observed significant volume loss among patients in the cerebellar cortices and vermis. Furthermore, this effect was strongest in a subgroup of 19 patients with a known, pathogenic mutation of the tuberous sclerosis 2 gene and impacted all cerebellar structures. We conclude that patients with tuberous sclerosis complex exhibit volume loss in the cerebellum, and this loss is larger and more widespread in patients with a tuberous sclerosis 2 mutation. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Weisenfeld, Neil I.; Peters, Jurriaan M.; Prabhu, Sanjay P.; Warfield, Simon K.] Harvard Univ, Childrens Hosp Boston, Sch Med, Dept Radiol, Boston, MA 02115 USA.
   [Peters, Jurriaan M.; Tsai, Peter T.; Dies, Kira A.; Sahin, Mustafa] Harvard Univ, Childrens Hosp Boston, Sch Med, Dept Neurol, Boston, MA 02115 USA.
RP Weisenfeld, NI (reprint author), Childrens Hosp, Dept Radiol, 300 Longwood Ave, Boston, MA 02115 USA.
EM weisen@crl.med.harvard.edu
FU NIH [R01 RR021885, R01 EB008015, R03 EB008680, R01 LM010033]; Boston
   Children's Hospital Translational Research Program; American Academy of
   Neurology; Nancy Lurie Marks Foundation; John Merck Scholars Fund
FX The authors are indebted to the children and families who participated
   in this study. The authors also wish to thank the staff of the
   Multi-Disciplinary Tuberous Sclerosis Program, as well as other staff at
   Boston Children's Hospital who were critical to this work. This
   investigation was supported in part by NIH grants R01 RR021885, R01
   EB008015, R03 EB008680, and R01 LM010033 (N.I.W., S.K.W.) and Boston
   Children's Hospital Translational Research Program (M.S., S.K.W.).
   P.T.T. was supported by the American Academy of Neurology and the Nancy
   Lurie Marks Foundation. M.S. was supported by the John Merck Scholars
   Fund.
CR Au Kit Sing, 2007, Genet Med, V9, P88, DOI 10.1097/GIM.0b013e31803068c7
   Avants BB, 2011, NEUROIMAGE, V54, P2033, DOI 10.1016/j.neuroimage.2010.09.025
   BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
   Benvenuto G, 2000, ONCOGENE, V19, P6306, DOI 10.1038/sj.onc.1204009
   Boer K, 2008, NEUROPATHOLOGY, V28, P577, DOI 10.1111/j.1440-1789.2008.00920.x
   Bolduc ME, 2012, CEREBELLUM, V11, P531, DOI 10.1007/s12311-011-0312-z
   Bolton PF, 2002, BRAIN, V125, P1247, DOI 10.1093/brain/awf124
   Commowick O, 2010, LECT NOTES COMPUT SC, V6363, P25
   COURCHESNE E, 1994, LANCET, V343, P63, DOI 10.1016/S0140-6736(94)90923-7
   Crooks R, 2000, EPILEPSY RES, V41, P63, DOI 10.1016/S0920-1211(00)00133-9
   Curatolo P, 2004, EUR J PAEDIATR NEURO, V8, P327, DOI 10.1016/j.ejpn.2004.08.005
   Curatolo P, 2008, LANCET, V372, P657, DOI 10.1016/S0140-6736(08)61279-9
   Dabora SL, 2001, AM J HUM GENET, V68, P64, DOI 10.1086/316951
   DiMario FJ, 2004, J CHILD NEUROL, V19, P650
   Di Nardo A, 2009, J NEUROSCI, V29, P5926, DOI 10.1523/JNEUROSCI.0778-09.2009
   Eluvathingal TJ, 2006, J CHILD NEUROL, V21, P846, DOI 10.2310/7010.2006.00192
   Ertan G, 2010, J NEURORADIOLOGY, V37, P231, DOI 10.1016/j.neurad.2009.12.006
   Gordon N, 2007, EUR J PAEDIATR NEURO, V11, P232, DOI 10.1016/j.ejpn.2007.02.003
   Gutmann DH, 2000, ACTA NEUROPATHOL, V99, P223
   Hodge SM, 2010, J AUTISM DEV DISORD, V40, P300, DOI 10.1007/s10803-009-0872-7
   Hyman MH, 2000, ARCH NEUROL-CHICAGO, V57, P662, DOI 10.1001/archneur.57.5.662
   Jeste SS, 2008, J CHILD NEUROL, V23, P520, DOI 10.1177/0883073807309788
   Jones AC, 1999, AM J HUM GENET, V64, P1305, DOI 10.1086/302381
   Langkau N, 2002, EUR J PEDIATR, V161, P393, DOI 10.1007/s00431-001-0903-7
   Lewis JC, 2004, J MED GENET, V41, P203, DOI 10.1136/jmg.2003.012757
   Noguchi KK, 2011, NEUROBIOL DIS, V43, P356, DOI 10.1016/j.nbd.2011.04.004
   Noguchi KK, 2008, CELL DEATH DIFFER, V15, P1582, DOI 10.1038/cdd.2008.97
   Numis AL, 2011, NEUROLOGY, V76, P981, DOI 10.1212/WNL.0b013e3182104347
   O'Halloran CJ, 2012, J CLIN EXP NEUROPSYC, V34, P35, DOI 10.1080/13803395.2011.614599
   Peters JM, 2012, ACAD RADIOL, V19, P17, DOI 10.1016/j.acra.2011.08.016
   Reith RM, 2011, NEUROBIOL DIS, V43, P113, DOI 10.1016/j.nbd.2011.02.014
   Ridler K, 2007, CEREB CORTEX, V17, P261, DOI 10.1093/cercor/bhj144
   Ridler K, 2004, J CHILD NEUROL, V19, P658
   Ridler K, 2001, PSYCHOL MED, V31, P1437
   Roach ES, 1998, J CHILD NEUROL, V13, P624
   Rohlfing T, 2004, IEEE T MED IMAGING, V23, P983, DOI 10.1109/TMI.2004.830803
   Sancak O, 2005, EUR J HUM GENET, V13, P731, DOI 10.1038/sj.ejhg.5201402
   Tsai P, 2011, CURR OPIN NEUROL, V24, P106, DOI 10.1097/WCO.0b013e32834451c4
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   Warfield SK, 2004, IEEE T MED IMAGING, V23, P903, DOI 10.1109/TMI.2004.828354
   Weber AM, 2000, J AUTISM DEV DISORD, V30, P511, DOI 10.1023/A:1005679108529
   Weisenfeld NI, 2009, NEUROIMAGE, V47, P564, DOI 10.1016/j.neuroimage.2009.04.068
   Weisenfeld Neil I, 2011, Med Image Comput Comput Assist Interv, V14, P322
   Whitwell JL, 2001, AM J NEURORADIOL, V22, P1483
   Winterkorn EB, 2007, NEUROLOGY, V68, P62, DOI 10.1212/01.wnl.0000250330.44291.54
   Yates JRW, 2011, ARCH DIS CHILD, V96, P1020, DOI 10.1136/adc.2011.211995
   Zeng LH, 2011, HUM MOL GENET, V20, P445, DOI 10.1093/hmg/ddq491
NR 47
TC 3
Z9 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0887-8994
EI 1873-5150
J9 PEDIATR NEUROL
JI Pediatr. Neurol.
PD FEB
PY 2013
VL 48
IS 2
BP 105
EP 110
DI 10.1016/j.pediatrneurol.2012.10.011
PG 6
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 081KW
UT WOS:000314322100003
PM 23337002
ER

PT J
AU Radulescu, E
   Ganeshan, B
   Minati, L
   Beacher, FDCC
   Gray, MA
   Chatwin, C
   Young, RCD
   Harrison, NA
   Critchley, HD
AF Radulescu, E.
   Ganeshan, B.
   Minati, L.
   Beacher, F. D. C. C.
   Gray, M. A.
   Chatwin, C.
   Young, R. C. D.
   Harrison, N. A.
   Critchley, H. D.
TI Gray matter textural heterogeneity as a potential in-vivo biomarker of
   fine structural abnormalities in Asperger syndrome
SO PHARMACOGENOMICS JOURNAL
LA English
DT Article
DE asperger syndrome; caudate; cerebellum; magnetic resonance imaging;
   texture analysis; voxel-based morphometry
ID AUTISM SPECTRUM DISORDERS; VOXEL-BASED MORPHOMETRY; BRAIN-DEVELOPMENT;
   BASAL GANGLIA; METAANALYSIS; VOLUME; NEUROANATOMY; DYSFUNCTION;
   CEREBELLUM; STRIATUM
AB Brain imaging studies contribute to the neurobiological understanding of Autism Spectrum Conditions (ASC). Herein, we tested the prediction that distributed neurodevelopmental abnormalities in brain development impact on the homogeneity of brain tissue measured using texture analysis (TA; a morphological method for surface pattern characterization). TA was applied to structural magnetic resonance brain scans of 54 adult participants (24 with Asperger syndrome (AS) and 30 controls). Measures of mean gray-level intensity, entropy and uniformity were extracted from gray matter images at fine, medium and coarse textures. Comparisons between AS and controls identified higher entropy and lower uniformity across textures in the AS group. Data reduction of texture parameters revealed three orthogonal principal components. These were used as regressors-of-interest in a voxel-based morphometry analysis that explored the relationship between surface texture variations and regional gray matter volume. Across the AS but not control group, measures of entropy and uniformity were related to the volume of the caudate nuclei, whereas mean gray-level was related to the size of the cerebellar vermis. Similar to neuropathological studies, our study provides evidence for distributed abnormalities in the structural integrity of gray matter in adults with ASC, in particular within corticostriatal and corticocerebellar networks. Additionally, this in-vivo technique may be more sensitive to fine microstructural organization than other more traditional magnetic resonance approaches and serves as a future testable biomarker in AS and other neurodevelopmental disorders. The Pharmacogenomics Journal (2013) 13, 70-79; doi:10.1038/tpj.2012.3; published online 14 February 2012
C1 [Radulescu, E.] Univ Sussex, CISC, Brighton & Sussex Med Sch, Dept Psychiat, Brighton BN1 9RR, E Sussex, England.
   [Radulescu, E.; Harrison, N. A.; Critchley, H. D.] Univ Sussex, Sackler Ctr Consciousness Sci, Brighton BN1 9RR, E Sussex, England.
   [Minati, L.] Fdn IRCCS Ist Neurol Carlo Besta, Dept Sci, Milan, Italy.
   [Beacher, F. D. C. C.] SUNY Stony Brook, Sch Med, Dept Biomed Engn, Stony Brook, NY 11794 USA.
   [Gray, M. A.] Monash Univ, Sch Psychol & Psychiat, Expt Neuropsychol Res Unit, Melbourne, Vic 3004, Australia.
   [Chatwin, C.; Young, R. C. D.] Univ Sussex, Dept Engn & Design, Brighton BN1 9RR, E Sussex, England.
   [Harrison, N. A.; Critchley, H. D.] Sussex Partnership NHS Fdn Trust, Neurobehav Clin, Sussex Educ Ctr, Hove, England.
RP Radulescu, E (reprint author), Univ Sussex, CISC, Brighton & Sussex Med Sch, Dept Psychiat, Brighton BN1 9RR, E Sussex, England.
EM e.radulescu@bsms.ac.uk
RI Gray, Marcus/F-6521-2013
OI Gray, Marcus/0000-0001-8671-6939
FU Dr Mortimer and Theresa Sackler Foundation; Wellcome Trust Programme
   Grant; Shirley Foundation
FX ER and partly HDC are supported by a donation from the 'Dr Mortimer and
   Theresa Sackler Foundation'. HDC was supported by a Wellcome Trust
   Programme Grant and LM was supported by the Shirley Foundation during
   the acquisition of this data. Dr Nicholas Dowell's assistance with
   imaging processing is acknowledged.
CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Ashburner J, 2009, NEUROIMAGE, V45, P333, DOI 10.1016/j.neuroimage.2008.12.008
   Ashburner J, 2007, STATISTICAL PARAMETRIC MAPPING: THE ANALYSIS OF FUNCTIONAL BRAIN IMAGES, P92, DOI 10.1016/B978-012372560-8/50007-3
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Beacher FD, 2012, AM J NEURORADIOL, V33, P83, DOI 10.3174/ajnr.A2880
   Bergouignan L, 2009, NEUROIMAGE, V45, P29, DOI 10.1016/j.neuroimage.2008.11.006
   Bolduc ME, 2011, DEV MED CHILD NEUROL, V53, P409, DOI 10.1111/j.1469-8749.2011.03929.x
   Brown R, 2008, CLIN CANCER RES, V14, P2357, DOI 10.1158/1078-0432.CCR-07-1964
   Casanova MF, 2002, J CHILD NEUROL, V17, P515, DOI 10.1177/088307380201700708
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Drabycz S, 2010, NEUROIMAGE, V49, P1398, DOI 10.1016/j.neuroimage.2009.09.049
   Draganski B, 2008, J NEUROSCI, V28, P7143, DOI 10.1523/JNEUROSCI.1486-08.2008
   Ecker C, 2011, J NEUROSCI, V30, P10612
   Ganeshan B, 2008, INVEST RADIOL, V43, P382, DOI 10.1097/RLI.0b013e3181690091
   Ganeshan B, 2009, EUR RADIOL, V20, P941
   GERFEN CR, 1992, ANNU REV NEUROSCI, V15, P285, DOI 10.1146/annurev.neuro.15.1.285
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Geschwind DH, 2008, CELL, V135, P391, DOI 10.1016/j.cell.2008.10.016
   Greco CM, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-2
   Hallahan B, 2009, PSYCHOL MED, V39, P337, DOI 10.1017/S0033291708003383
   Hardeveld F, 2009, ACTA PSYCHIAT SCAND, V122, P184, DOI DOI 10.1111/J.1600-0447.2009.01519.X
   Haznedar MM, 2006, AM J PSYCHIAT, V163, P1252, DOI 10.1176/appi.ajp.163.7.1252
   Holli Kirsi K, 2010, BMC Med Imaging, V10, P8, DOI 10.1186/1471-2342-10-8
   Jafari-Khouzani K, 2010, NEUROIMAGE, V49, P1559, DOI 10.1016/j.neuroimage.2009.08.064
   Jiao Y, 2011, NEUROIMAGE, V50, P589
   Juntu J, 2010, J MAGN RESON IMAGING, V31, P680, DOI 10.1002/jmri.22095
   Kassner A, 2010, AM J NEURORADIOL, V31, P809, DOI 10.3174/ajnr.A2061
   Knickmeyer RC, 2008, J NEUROSCI, V28, P12176, DOI 10.1523/JNEUROSCI.3479-08.2008
   Kovalev VA, 2003, PSYCHIAT RES-NEUROIM, V124, P177, DOI 10.1016/S0925-4927(03)00070-2
   Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
   Leekam SR, 2002, J CHILD PSYCHOL PSYC, V43, P327, DOI 10.1111/1469-7610.00024
   Limperopoulos C, 2009, PEDIATR NEUROL, V41, P1, DOI 10.1016/j.pediatrneurol.2009.02.007
   Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
   Mangin JF, 2010, CURR OPIN NEUROL, V23, P359, DOI 10.1097/WCO.0b013e32833a0afc
   McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150
   Minshew NJ, 2010, CURR OPIN NEUROL, V23, P124, DOI 10.1097/WCO.0b013e32833782d4
   NELSON HE, 1978, CORTEX, V14, P234
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   Nolf EX, 2003, EUR J NUCL MED S2, V30, pS246
   Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007
   Ostby Y, 2009, J NEUROSCI, V29, P11772, DOI 10.1523/JNEUROSCI.1242-09.2009
   Palmen SJMC, 2005, PSYCHOL MED, V35, P561, DOI 10.1017/S0033291704003496
   Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
   Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
   Rorden C, 2000, BEHAV NEUROL, V12, P191
   Sadakata T, 2007, J NEUROSCI, V27, P2472, DOI 10.1523/JNEUROSCI.2279-06.2007
   Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007
   Scott JA, 2009, AUTISM RES, V2, P246, DOI 10.1002/aur.97
   Sillitoe RV, 2007, ANNU REV CELL DEV BI, V23, P549, DOI 10.1146/annurev.cellbio.23.090506.123237
   Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006
   Theocharakis P, 2009, MAGN RESON IMAGING, V27, P417, DOI 10.1016/j.mri.2008.07.014
   Verhoeven JS, 2010, NEURORADIOLOGY, V52, P3, DOI 10.1007/s00234-009-0583-y
   Via E, 2011, ARCH GEN PSYCHIAT, V68, P409, DOI 10.1001/archgenpsychiatry.2011.27
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Volpe JJ, 2009, J CHILD NEUROL, V24, P1085, DOI 10.1177/0883073809338067
   Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
   Woodbury-Smith MR, 2009, EUR CHILD ADOLES PSY, V18, P2, DOI 10.1007/s00787-008-0701-0
   Yassa MA, 2009, NEUROIMAGE, V44, P319, DOI 10.1016/j.neuroimage.2008.09.016
NR 62
TC 4
Z9 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1470-269X
J9 PHARMACOGENOMICS J
JI Pharmacogenomics J.
PD FEB
PY 2013
VL 13
IS 1
BP 70
EP 79
DI 10.1038/tpj.2012.3
PG 10
WC Genetics & Heredity; Pharmacology & Pharmacy
SC Genetics & Heredity; Pharmacology & Pharmacy
GA 079ZI
UT WOS:000314210400009
PM 22333911
ER

PT J
AU Wills, AJ
   Milton, F
   Longmore, CA
   Hester, S
   Robinson, J
AF Wills, Andy J.
   Milton, Fraser
   Longmore, Christopher A.
   Hester, Sarah
   Robinson, Jo
TI Is overall similarity classification less effortful than
   single-dimension classification?
SO QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY
LA English
DT Article
DE Analytic; Nonanalytic; Overall similarity; Categorization; Family
   resemblance
ID HUMANS HOMO-SAPIENS; CATEGORY CONSTRUCTION; FAMILY-RESEMBLANCE;
   MULTIDIMENSIONAL STIMULI; TASK INTERFERENCE; LEARNING-SYSTEMS;
   CATEGORIZATION; PERCEPTION; ATTENTION; AUTISM
AB It is sometimes argued that the implementation of an overall similarity classification is less effortful than the implementation of a single-dimension classification. In the current article, we argue that the evidence securely in support of this view is limited, and report additional evidence in support of the opposite propositionoverall similarity classification is more effortful than single-dimension classification. Using a match-to-standards procedure, Experiments 1A, 1B and 2 demonstrate that concurrent load reduces the prevalence of overall similarity classification, and that this effect is robust to changes in the concurrent load task employed, the level of time pressure experienced, and the short-term memory requirements of the classification task. Experiment 3 demonstrates that participants who produced overall similarity classifications from the outset have larger working memory capacities than those who produced single-dimension classifications initially, and Experiment 4 demonstrates that instructions to respond meticulously increase the prevalence of overall similarity classification.
C1 [Wills, Andy J.; Milton, Fraser; Longmore, Christopher A.; Hester, Sarah; Robinson, Jo] Univ Exeter, Exeter, Devon, England.
RP Wills, AJ (reprint author), Univ Plymouth, Sch Psychol, Plymouth PL4 8AA, Devon, England.
EM andy@willslab.co.uk
FU ESRC [RES-000-22-1779, PTA-026-27-1256]; Great Western Research
   Fellowship
FX This research was supported by ESRC grant RES-000-22-1779 awarded to
   Andy J. Wills and ESRC Grant PTA-026-27-1256 and a Great Western
   Research Fellowship awarded to Fraser Milton. Andy J. Wills and
   Christopher A. Longmore are now at the School of Psychology, Plymouth
   University.
CR Ashby FG, 1998, PSYCHOL REV, V105, P442, DOI 10.1037/0033-295X.105.3.442
   Ashby F Gregory, 2005, Annu Rev Psychol, V56, P149, DOI 10.1146/annurev.psych.56.091103.070217
   Goldstone RL, 1998, COGNITION, V65, P231, DOI 10.1016/S0010-0277(97)00047-4
   Bott L, 2006, Q J EXP PSYCHOL, V59, P1237, DOI 10.1080/02724980543000196
   Brooks L. R., 1978, COGNITION CATEGORIZA, P169
   Brooks LR, 2007, MEM COGNITION, V35, P1, DOI 10.3758/BF03195937
   Cianciolo A.T., 2004, INTELLIGENCE BRIEF H
   Couchman JJ, 2010, J EXP PSYCHOL ANIM B, V36, P172, DOI 10.1037/a0016748
   Dijksterhuis A, 2006, SCIENCE, V311, P1005, DOI 10.1126/science.1121629
   Edwards DJ, 2012, RES DEV DISABIL, V33, P1264, DOI 10.1016/j.ridd.2012.02.021
   Filoteo JV, 2010, PSYCHOL SCI, V21, P415, DOI 10.1177/0956797610362646
   Garner W. R., 1974, PROCESSING INFORM ST
   Goshen-Gottstein Y, 2000, J EXP PSYCHOL LEARN, V26, P1198, DOI 10.1037//0278-7393.26.5.1198
   NELSON DGK, 1988, MEM COGNITION, V16, P79
   NELSON DGK, 1984, J VERB LEARN VERB BE, V23, P734
   Lamberts K, 1998, J EXP PSYCHOL LEARN, V24, P695, DOI 10.1037//0278-7393.24.3.695
   LOGAN GD, 1988, PSYCHOL REV, V95, P492, DOI 10.1037//0033-295X.95.4.492
   Macrae CN, 2007, EUR J SOC PSYCHOL, V37, P793, DOI 10.1002/ejsp.406
   Maddox WT, 2010, NEUROPSYCHOLOGIA, V48, P2998, DOI 10.1016/j.neuropsychologia.2010.06.008
   MEDIN DL, 1987, COGNITIVE PSYCHOL, V19, P242, DOI 10.1016/0010-0285(87)90012-0
   MERVIS CB, 1981, ANNU REV PSYCHOL, V32, P89, DOI 10.1146/annurev.ps.32.020181.000513
   Milton F, 2009, ACTA PSYCHOL, V130, P161, DOI 10.1016/j.actpsy.2008.12.001
   Milton F, 2011, EUR J NEUROSCI, V34, P1326, DOI 10.1111/j.1460-9568.2011.07847.x
   Milton F, 2008, J EXP PSYCHOL HUMAN, V34, P676, DOI 10.1037/0096-1523.34.3.676
   Milton F, 2004, J EXP PSYCHOL LEARN, V30, P407, DOI 10.1037/0278-7393.30.2.407
   Milton F, 2009, NEUROIMAGE, V46, P319, DOI 10.1016/j.neuroimage.2009.01.043
   Newell B. R., 2010, PSYCHOL SCI
   Newell BR, 2010, MEM COGNITION, V38, P563, DOI 10.3758/MC.38.5.563
   Patalano AL, 2001, COGN AFFECT BEHAV NE, V1, P360, DOI 10.3758/CABN.1.4.360
   Psychological Software Tools, 2002, E PRIM
   REGEHR G, 1995, J EXP PSYCHOL LEARN, V21, P347, DOI 10.1037//0278-7393.21.2.347
   ROSCH E, 1975, COGNITIVE PSYCHOL, V7, P573, DOI 10.1016/0010-0285(75)90024-9
   WARD TB, 1987, MEM COGNITION, V15, P42, DOI 10.3758/BF03197711
   Sloman SA, 1996, PSYCHOL BULL, V119, P3, DOI 10.1037//0033-2909.119.1.3
   SMITH JD, 1984, J EXP PSYCHOL GEN, V113, P137, DOI 10.1037/a0015892
   SMITH JD, 1989, J MEM LANG, V28, P386, DOI 10.1016/0749-596X(89)90018-1
   SMITH JD, 1993, J EXP PSYCHOL GEN, V122, P331, DOI 10.1037/0096-3445.122.3.331
   Tharp Ian J, 2009, Cognition, V111, P411, DOI 10.1016/j.cognition.2008.10.003
   THORPE SJ, 1989, CONNECTIONISM IN PERSPECTIVE, P63
   Tracy JI, 2003, BRAIN COGNITION, V51, P276, DOI 10.1016/S0278-2626(03)00052-6
   TURNER ML, 1989, J MEM LANG, V28, P127, DOI 10.1016/0749-596X(89)90040-5
   Waldron EM, 2001, PSYCHON B REV, V8, P168, DOI 10.3758/BF03196154
   WARD TB, 1983, J EXP PSYCHOL HUMAN, V9, P103, DOI 10.1037//0096-1523.9.1.103
   WARD TB, 1986, J EXP PSYCHOL HUMAN, V12, P211, DOI 10.1037//0096-1523.12.2.211
   WATTENMAKER WD, 1992, J EXP PSYCHOL LEARN, V18, P1125, DOI 10.1037//0278-7393.18.5.1125
   Wills AJ, 2009, J COMP PSYCHOL, V123, P391, DOI 10.1037/a0016216
   Zeithamova D, 2006, MEM COGNITION, V34, P387, DOI 10.3758/BF03193416
NR 47
TC 1
Z9 1
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 1747-0218
J9 Q J EXP PSYCHOL
JI Q. J. Exp. Psychol.
PD FEB 1
PY 2013
VL 66
IS 2
BP 299
EP 318
DI 10.1080/17470218.2012.708349
PG 20
WC Psychology, Biological; Physiology; Psychology; Psychology, Experimental
SC Psychology; Physiology
GA 079GE
UT WOS:000314157800007
PM 22897383
ER

PT J
AU Jones, KL
   Will, MJ
   Hecht, PM
   Parker, CL
   Beversdorf, DQ
AF Jones, Karen L.
   Will, Matt. J.
   Hecht, Patrick M.
   Parker, Cassandra L.
   Beversdorf, David Q.
TI Maternal diet rich in omega-6 polyunsaturated fatty acids during
   gestation and lactation produces autistic-like sociability deficits in
   adult offspring
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Behavior; Autism spectrum disorders; Prenatal stress; Diet;
   Polyunsaturated fatty acids
ID PRENATAL STRESS; BRAIN-DEVELOPMENT; INFANTILE-AUTISM; TWIN PAIRS;
   PREGNANCY; CHILDREN; MICE; IMMUNOGLOBULIN; DISORDER; ANXIETY
AB Multiple studies have reported prenatal stress as a potential risk factor for the development of autism spectrum disorder (ASD). In rodents, a significant reduction in sociability is seen in prenatally stressed offspring of genetically stress-susceptible dams. Certain dietary factors that contribute to stress reactivity may, therefore, exacerbate prenatal stress-mediated behavioral changes in adult offspring. Adults with a diet rich in omega-6 polyunsaturated fatty acids (PUFAs) display increased stress reactivity. In the current study, the effects of prenatal diet and prenatal stress on social behavior in adult offspring mice were examined. Pregnant C57BL/6J dams received either chronic variable stress or no stress, and were also placed on a control diet or a diet rich in omega-6 PUFAs, in a 2 x 2 design. We subsequently tested the adult offspring for sociability, anxiety, and locomotor behaviors using a 3-chambered social approach task, an elevated-plus maze, an open field task and a rotarod task. Results indicated that a maternal diet rich in omega-6 PUFAs during gestation and lactation produce changes in sociability consistent with those observed in ASD. Additionally, offspring exposed to a diet rich in omega-6 PUFAs during gestation and lactation had increased levels of anxiety in the elevated-plus maze. Prenatal stress had no effect on offspring behavior. These findings provide evidence for a possible environmental risk factor that contributes to the production of autistic-like behavior in mice. (c) 2012 Elsevier B.V. All rights reserved.
C1 [Jones, Karen L.; Will, Matt. J.; Hecht, Patrick M.; Beversdorf, David Q.] Univ Missouri, Interdisciplinary Neurosci Program, Columbia, MO 65211 USA.
   [Jones, Karen L.; Will, Matt. J.; Hecht, Patrick M.; Beversdorf, David Q.] Univ Missouri, Thompson Ctr Autism & Neurodev Disorders, Columbia, MO 65211 USA.
   [Will, Matt. J.; Parker, Cassandra L.; Beversdorf, David Q.] Univ Missouri, Dept Psychol, Columbia, MO 65211 USA.
   [Beversdorf, David Q.] Univ Missouri, Dept Radiol, Columbia, MO 65211 USA.
   [Beversdorf, David Q.] Univ Missouri, Dept Neurol, Columbia, MO 65211 USA.
RP Beversdorf, DQ (reprint author), Univ Missouri, Interdisciplinary Neurosci Program, 130E Thompson Ctr,205 Portland St, Columbia, MO 65211 USA.
EM KLJones@mail.missouri.edu; Willm@missouri.edu; pmhp6d@mail.missouri.edu;
   clphf2@mail.missouri.edu; beversdorfd@health.missouri.edu
FU Kansas City Life Science Patton Research Grant; University of Missouri
   Research Investment Fund
FX This research was supported by the Kansas City Life Science Patton
   Research Grant and the University of Missouri Research Investment Fund.
CR Ahmad A, 2002, PEDIATR NEUROL, V26, P210, DOI 10.1016/S0887-8994(01)00383-6
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Bauman M.L, 1994, NEUROBIOLOGY AUTISM
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Bazan NG, 2006, TRENDS NEUROSCI, V29, P263, DOI 10.1016/j.tins.2006.03.005
   Beversdorf DQ, 2005, J AUTISM DEV DISORD, V35, P471, DOI 10.1007/s10803-005-5037-8
   Blatt GJ, 2001, J AUTISM DEV DISORD, V31, P537, DOI 10.1023/A:1013238809666
   Braunschweig D, 2008, NEUROTOXICOLOGY, V29, P226, DOI 10.1016/j.neuro.2007.10.010
   Calder PC, 2003, LIPIDS, V38, P343, DOI 10.1007/s11745-003-1068-y
   Castro SL, 2001, BRAIN RES, V901, P47, DOI 10.1016/S0006-8993(01)02229-6
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Crawley JN, 1999, BRAIN RES, V835, P18, DOI 10.1016/S0006-8993(98)01258-X
   Croonenberghs J, 2002, PSYCHOL MED, V32, P1457, DOI 10.1017/S0033291702006037
   Darnaudery M, 2004, BEHAV BRAIN RES, V153, P211, DOI 10.1016/j.bbr.2003.12.001
   Famagalli F, 2005, NEUROBIOL DIS, V20, P731
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
   Fumagalli F, 2004, EUR J NEUROSCI, V20, P1348, DOI 10.1111/j.1460-9568.2004.03592.x
   Georgieff M.K., 2005, PEDIATR RES, V57, P99
   Ghaziuddin M., 2002, FOCUS AUTISM OTHER D, V17, P138, DOI DOI 10.1177/10883576020170030301
   Gitau R, 1998, LANCET, V352, P707, DOI 10.1016/S0140-6736(05)60824-0
   Goines P, 2010, CURR OPIN NEUROL, V23, P111, DOI 10.1097/WCO.0b013e3283373514
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Harauma A, 2011, LIPIDS, V46, P409, DOI 10.1007/s11745-010-3523-z
   Heuer L, 2008, AUTISM RES, V1, P275, DOI 10.1002/aur.42
   Hibbeln JR, 2007, LANCET, V369, P578, DOI 10.1016/S0140-6736(07)60277-3
   Innis SM, 2007, J NUTR, V137, P855
   Jones KL, 2010, INT J DEV NEUROSCI, V28, P529, DOI 10.1016/j.ijdevneu.2010.05.002
   Kiecolt-Glaser JK, 2007, PSYCHOSOM MED, V69, P217, DOI 10.1097/PSY.0b013e3180313a45
   Kinney DK, 2008, J AUTISM DEV DISORD, V38, P481, DOI 10.1007/s10803-007-0414-0
   Koletzko B, 2008, J PERINAT MED, V36, P5, DOI 10.1515/JPM.2008.001
   Lemaire V, 2006, BIOL PSYCHIAT, V59, P786, DOI 10.1016/j.biopsych.2005.11.009
   Lemaire V, 2000, P NATL ACAD SCI USA, V97, P11032, DOI 10.1073/pnas.97.20.11032
   Lesage J, 2002, J NEUROENDOCRINOL, V14, P135, DOI 10.1046/j.0007-1331.2001.00753.x
   LISTER RG, 1987, PSYCHOPHARMACOLOGY, V92, P180
   Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
   Mu X, 2011, PHARMACOL BIOCHEM BE, V98, P286, DOI 10.1016/j.pbb.2011.01.011
   Mueller BR, 2006, PHYSIOL BEHAV, V88, P605, DOI 10.1016/j.physbeh.2006.05.019
   Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x
   Oken E, 2008, AM J CLIN NUTR, V88, P789
   PLIOPLYS AV, 1994, NEUROPSYCHOBIOLOGY, V29, P12, DOI 10.1159/000119056
   Schuchardt JP, 2010, EUR J PEDIATR, V169, P149, DOI 10.1007/s00431-009-1035-8
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Simopoulos AP, 2002, BIOMED PHARMACOTHER, V56, P365, DOI 10.1016/S0753-3322(02)00253-6
   Sjostrom K, 1997, EUR J OBSTET GYN R B, V74, P149, DOI 10.1016/S0301-2115(97)00100-0
   Son GH, 2006, J NEUROSCI, V26, P3309, DOI 10.1523/JNEUROSCI.3850-05.2006
   STUBBS EG, 1977, J AUTISM CHILD SCHIZ, V7, P49, DOI 10.1007/BF01531114
   Suzuki T, 2007, ANESTH ANALG, V104, P1570, DOI 10.1213/01.ane.0000261514.19946.66
   Sweeten TL, 2003, AM J PSYCHIAT, V160, P1691, DOI 10.1176/appi.ajp.160.9.1691
   Trajkovski V, 2004, CROAT MED J, V45, P746
   Uauy R, 2006, NUTR REV, V64, pS72
   Uauy R, 2006, NUTR REV, V64, pS24, DOI 10.1301/nr.2006.may.S24-S33
   Vancassel S, 2001, PROSTAG LEUKOTR ESS, V65, P1, DOI 10.1054/plef.2001.0281
   Wainwright PE, 2002, P NUTR SOC, V61, P61, DOI 10.1079/PNS2001130
   WARD AJ, 1990, CHILD PSYCHIAT HUM D, V20, P279, DOI 10.1007/BF00706020
   WARREN RP, 1990, J AM ACAD CHILD PSY, V29, P873, DOI 10.1097/00004583-199011000-00005
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3
NR 62
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD FEB 1
PY 2013
VL 238
BP 193
EP 199
DI 10.1016/j.bbr.2012.10.028
PG 7
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 078ZE
UT WOS:000314138800025
PM 23098794
ER

PT J
AU Smith, AL
   Freeman, SM
   Voll, RJ
   Young, LJ
   Goodman, MM
AF Smith, Aaron L.
   Freeman, Sara M.
   Voll, Ronald J.
   Young, Larry J.
   Goodman, Mark M.
TI Carbon-11 N-methyl alkylation of L-368,899 and in vivo PET imaging
   investigations for neural oxytocin receptors
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Oxytocin; Vasopressin; PET imaging; L-368,899; Pituitary; Receptor
   imaging
ID BLOOD-BRAIN-BARRIER; PRETERM LABOR; GENE OXTR; AUTISM; ASSOCIATION;
   VASOPRESSIN; ANTAGONIST; BEHAVIOR; CHILDREN
AB Compound L-368,899 was successfully alkylated with [C-11] iodomethane to generate the oxytocin receptor selective (2R)-2-amino-N-((2S)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin-1-yl)sulfonyl)methyl) bicyclo[2.2.1]heptan-2-yl)-N-[C-11]methyl-3-(methylsulfonyl)propanamide ([C-11]1) with very high radio-chemical purity and high specific activity. PET imaging studies were performed with [C-11]1 to investigate brain penetration and oxytocin receptor uptake using rat and cynomolgus monkey models. For rat baseline scans, brain penetration was observed with [C-11]1, but no specific uptake could be distinguished in the brain region. By administering a peptide oxytocin receptor selective antagonist for peripheral blocking of oxytocin receptors, the uptake of [C-11]1 was amplified in the rat brain temporarily to enable some visual uptake within the rat brain. A baseline scan of [C-11]1 in a cynomolgus monkey model resulted in no detectable specific uptake in anticipated regions, but activity did accumulate in the choroid plexus. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Smith, Aaron L.; Freeman, Sara M.; Young, Larry J.] Yerkes Natl Primate Res Ctr, Dept Psychiat & Behav Sci, Ctr Translat Social Neurosci, Atlanta, GA 30322 USA.
   [Smith, Aaron L.; Voll, Ronald J.; Goodman, Mark M.] Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30329 USA.
RP Goodman, MM (reprint author), Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30329 USA.
EM mgoodma@emory.edu
FU National Institute of Mental Health [5 R21 MH090776]; NIH [MH064692];
   National Center for Research Resources [P51RR165, P51OD11132]
FX We thank Larry Williams, Mel Camp, and Eugene Malveaux for their
   contributions in the rodent studies. We thank the Yerkes National
   Primate Center's imaging suite staff for primate imaging. We thank the
   NIMH PDSP directed by Bryan L. Roth MD, PhD at the University of North
   Carolina at Chapel Hill and Project Officer Jamie Driscol at NIMH,
   Bethesda MD, USA for their contributions of the human cell line studies.
   This research was funded by the National Institute of Mental Health
   through grant 5 R21 MH090776. We also acknowledge NIH MH064692 (LJY) and
   the National Center for Research Resources P51RR165 (currently
   P51OD11132) to YNPRC.
CR Andari E, 2010, P NATL ACAD SCI US
   Bauer M, 2010, J CEREBR BLOOD F MET, V30, P510, DOI 10.1038/jcbfm.2009.265
   Boccia ML, 2007, HORM BEHAV, V52, P344, DOI 10.1016/j.yhbeh.2007.05.009
   Donaldson ZR, 2008, SCIENCE, V322, P900, DOI 10.1126/science.1158668
   Eyal S, 2010, CLIN PHARMACOL THER, V87, P579, DOI 10.1038/clpt.2010.11
   Ferguson JN, 2001, J NEUROSCI, V21, P8278
   Goodson JL, 2009, SCIENCE, V325, P862, DOI 10.1126/science.1174929
   Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62
   Guastella A. J, 2009, BIOL PSYCHIAT
   Guastella Adam J, 2012, Horm Behav, V61, P410, DOI 10.1016/j.yhbeh.2012.01.002
   Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
   Kreisl WC, 2010, J NUCL MED, V51, P559, DOI 10.2967/jnumed.109.070151
   Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087
   Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
   Modi ME, 2012, HORM BEHAV, V61, P340, DOI 10.1016/j.yhbeh.2011.12.010
   PETTIBONE DJ, 1993, DRUG DEVELOP RES, V30, P129, DOI 10.1002/ddr.430300305
   Ross HE, 2009, FRONT NEUROENDOCRIN, V30, P534, DOI 10.1016/j.yfrne.2009.05.004
   Schorscher-Petcu A, 2009, NEUROSCI LETT, V461, P217, DOI 10.1016/j.neulet.2009.06.016
   Smith AL, 2012, BIOORGAN MED CHEM, V20, P2721, DOI 10.1016/j.bmc.2012.02.019
   Smith AS, 2010, HORM BEHAV, V57, P255, DOI 10.1016/j.yhbeh.2009.12.004
   Toloczko DM, 1997, ANN NY ACAD SCI, V807, P506, DOI 10.1111/j.1749-6632.1997.tb51953.x
   TRIBOLLET E, 1989, J NEUROSCI, V9, P1764
   WILLIAMS PD, 1994, J MED CHEM, V37, P565, DOI 10.1021/jm00031a004
   Wilson AA, 1999, J LABELLED COMPD RAD, V42, P1277, DOI 10.1002/(SICI)1099-1344(19991230)42:13<1277::AID-JLCR284>3.0.CO;2-Q
   Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
   Young LJ, 2012, HORM BEHAV, V61, P227, DOI 10.1016/j.yhbeh.2012.02.019
NR 26
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD FEB 1
PY 2013
VL 23
IS 3
BP 902
EP 906
DI 10.1016/j.bmcl.2012.10.116
PG 5
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA 072SZ
UT WOS:000313694200063
PM 23270988
ER

PT J
AU Garcia-Filion, P
   Borchert, M
AF Garcia-Filion, Pamela
   Borchert, Mark
TI Optic Nerve Hypoplasia Syndrome: A Review of the Epidemiology and
   Clinical Associations
SO CURRENT TREATMENT OPTIONS IN NEUROLOGY
LA English
DT Review
DE Optic nerve hypoplasia; Septo-optic dysplasia; DeMorsier's syndrome;
   Hypothalamic dysfunction; Hypopituitarism; Pediatric visual impairment;
   Developmental delay; Birth defect; Epidemiology
ID PITUITARY-HORMONE DEFICIENCY; FETAL ALCOHOL SYNDROME; CORPUS-CALLOSUM;
   RISK-FACTORS; PERIVENTRICULAR LEUKOMALACIA; SEPTOOPTIC DYSPLASIA; SYSTEM
   ABNORMALITIES; CIRCADIAN-RHYTHMS; SEPTUM-PELLUCIDUM; KALLMANN-SYNDROME
AB Background: Optic nerve hypoplasia (ONH) has developed into a leading cause of congenital blindness. The frequently associated features of hypopituitarism and absent septum pellucidum were felt to have embryonic linkage as "septo-optic dysplasia" or "de Morsier's syndrome." More recent studies have suggested these associations are independent of one another. This review provides an assessment of the historical and recent evidence linking neuroradiologic, endocrinologic and developmental morbidity in patients with ONH. The prenatal risk factors, heritability, and genetic mutations associated with ONH are described. Results: Recognition of the critical association of ONH with hypopituitarism should be attributed to William Hoyt, not Georges de Morsier. De Morsier never described a case of ONH or recognized its association with hypopituitarism or missing septum pellucidum. Hypopituitarism is caused by hypothalamic dysfunction. This, and other more recently identified associations with ONH, such as developmental delay and autism, are independent of septum pellucidum development. Other common neuroradiographic associations such as corpus callosum hypoplasia, gyrus dysplasia, and cortical heterotopia may have prognostic significance. The predominant prenatal risk factors for ONH are primiparity and young maternal age. Presumed risk factors such as prenatal exposure to drugs and alcohol are not supported by scrutiny of the literature. Heritability and identified gene mutations in cases of ONH are rare. Conclusion: Children with ONH require monitoring for many systemic, developmental, and even life-threatening problems independent of the severity of ONH and presence of brain malformations including abnormalities of the septum pellucidum. "Septo-optic dysplasia" and "de Morsier's syndrome" are historically inaccurate and clinically misleading terms.
C1 [Garcia-Filion, Pamela] Childrens Hosp Los Angeles, Vis Ctr, Los Angeles, CA 90027 USA.
   [Borchert, Mark] Univ So Calif, Keck Med Ctr, Los Angeles, CA 90027 USA.
RP Garcia-Filion, P (reprint author), Childrens Hosp Los Angeles, Vis Ctr, 4650 Sunset Blvd,MS 88, Los Angeles, CA 90027 USA.
EM pgarciafilion@chla.usc.edu
CR Ahmad T, 2006, J PEDIATR-US, V148, P78, DOI 10.1016/j.jpeds.2005.08.050
   Ang SL, 1996, DEVELOPMENT, V122, P243
   BENNER JD, 1990, AM J OPHTHALMOL, V109, P632
   Birkebaek NH, 2004, J PEDIATR-US, V145, P536, DOI 10.1016/j.jpeds.2004.06.041
   Birkebaek NH, 2003, J CLIN ENDOCR METAB, V88, P5281, DOI 10.1210/jc.2003-030527
   Blohme J, 2000, ACTA OPHTHALMOL SCAN, V78, P416, DOI 10.1034/j.1600-0420.2000.078004416.x
   Blohme J, 1997, ACTA OPHTHALMOL SCAN, V75, P681
   Borchert M, 2012, J NEURO-OPHTHALMOL, V32, P58, DOI 10.1097/WNO.0b013e31824442b8
   BORCHERT M, 1995, AM J OPHTHALMOL, V120, P605
   Brinkmeier ML, 2009, GENOMICS, V93, P449, DOI 10.1016/j.ygeno.2008.11.010
   BRODSKY MC, 1993, ARCH OPHTHALMOL-CHIC, V111, P66
   BRODSKY MC, 1990, ARCH OPHTHALMOL-CHIC, V108, P1562
   Brodsky MC, 2001, ARCH OPHTHALMOL-CHIC, V119, P626
   Brown R, 1997, J CHILD PSYCHOL PSYC, V38, P693, DOI 10.1111/j.1469-7610.1997.tb01696.x
   BURKE JP, 1991, BRIT J OPHTHALMOL, V75, P236, DOI 10.1136/bjo.75.4.236
   Cidis M B, 1997, J Am Optom Assoc, V68, P325
   Cohen RN, 2003, J CLIN ENDOCR METAB, V88, P4832, DOI 10.1210/jc.2002-021868
   COSTIN G, 1985, AM J DIS CHILD, V139, P249
   Dattani MT, 1998, NAT GENET, V19, P125, DOI 10.1038/477
   DE MORSIER G, 1956, Schweiz Arch Neurol Psychiatr, V77, P267
   DeCarlo D K, 1999, J Am Optom Assoc, V70, P647
   EDGAR DM, 1993, J NEUROSCI, V13, P1065
   Ek U, 2005, ACTA PAEDIATR, V94, P1421, DOI 10.1080/08035250510037290
   Elmquist JK, 2001, PHYSIOL BEHAV, V74, P703, DOI 10.1016/S0031-9384(01)00613-8
   Fink C, 2011, J VISUAL IMPAIR BLIN, V105, P334
   Fink C, 2012, J AAPOS IN PRESS
   Garcia ML, 2006, J CHILD NEUROL, V21, P949, DOI 10.2310/7010.2006.00241
   Garcia-Filion P, 2010, ACTA OPHTHALMOL, V88, P527, DOI 10.1111/j.1755-3768.2008.01450.x
   Garcia-Filion P, 2008, PEDIATRICS, V121, pE653, DOI 10.1542/peds.2007-1825
   Glass HC, 2008, AM J MED GENET A, V146A, P2495, DOI 10.1002/ajmg.a.32418
   Gorbenko Del Blanco D., 2012, EUR J ENDOCRINOL
   GRIFFITHS P, 1984, DEV MED CHILD NEUROL, V26, P395
   Gross H., 1959, MALFORMATIONS CONGEN, P329
   HACKENBRUCH Y, 1975, AM J OPHTHALMOL, V79, P314
   Haddad NG, 2005, J PEDIATR ENDOCR MET, V18, P853
   Hatton DD, 2007, J AAPOS, V11, P351, DOI 10.1016/j.jaapos.2007.01.107
   Hellstrom A, 1999, J CLIN ENDOCR METAB, V84, P795, DOI 10.1210/jc.84.2.795
   Hellstrom A, 1999, J AAPOS, V3, P104, DOI 10.1016/S1091-8531(99)70079-0
   Hellstrom A, 1999, J AAPOS, V3, P212, DOI 10.1016/S1091-8531(99)70005-4
   HITTNER HM, 1976, AM J OPHTHALMOL, V81, P661
   HOTCHKISS ML, 1979, J PEDIAT OPHTH STRAB, V16, P225
   HOYT CS, 1978, BRIT J OPHTHALMOL, V62, P3, DOI 10.1136/bjo.62.1.3
   HOYT WF, 1970, LANCET, V1, P893
   Jacobson L, 1997, ARCH OPHTHALMOL-CHIC, V115, P1263
   JAN JE, 1977, DEV MED CHILD NEUROL, V19, P353
   Kelberman D, 2008, HORM RES, V69, P257, DOI 10.1159/000114856
   KIM RY, 1989, ARCH OPHTHALMOL-CHIC, V107, P1312
   KUCHARCZYK W, 1990, AM J NEURORADIOL, V11, P693
   Ma NS, 2010, J PEDIATR ENDOCR MET, V23, P53
   MAGOON EH, 1981, ARCH OPHTHALMOL-CHIC, V99, P655
   MARGALITH D, 1984, DEV MED CHILD NEUROL, V26, P311
   McCulloch DL, 2010, BRIT J OPHTHALMOL, V94, P1017, DOI 10.1136/bjo.2009.161117
   McMahon CL, 2001, TERATOLOGY, V64, P83, DOI 10.1002/tera.1049
   Mcnay DEG, 2007, J CLIN ENDOCR METAB, V92, P691, DOI 10.1210/jc.2006-1609
   Mellado C, 2010, AM J MED GENET A, V152A, P2736, DOI 10.1002/ajmg.a.33684
   Melmed S, 2011, J CLIN ENDOCR METAB, V96, P273, DOI 10.1210/jc.2010-1692
   Mets M B, 1999, Trans Am Ophthalmol Soc, V97, P653
   KYTILAE J, 1961, ACTA OPHTHALMOL, V39, P416
   Miller SP, 2000, NEUROLOGY, V54, P1701
   Missiroli S., 1947, B OCUL, V26, P683
   Moore RY, 1997, ANNU REV MED, V48, P253, DOI 10.1146/annurev.med.48.1.253
   MOOREEDE MC, 1983, NEW ENGL J MED, V309, P469, DOI 10.1056/NEJM198308253090806
   MOSIER MA, 1978, ARCH OPHTHALMOL-CHIC, V96, P1437
   Murray PG, 2005, J PEDIATR ENDOCR MET, V18, P471
   Panda S, 2002, NATURE, V417, P329, DOI 10.1038/417329a
   Parr J. R, 2010, DEV MED CHILD NEUROL
   PATEL H, 1975, AM J DIS CHILD, V129, P175
   Patel L, 2006, J PEDIATR-US, V148, P85, DOI 10.1016/j.jpeds.2005.07.031
   Phillips PH, 2001, J AAPOS, V5, P275, DOI 10.1067/mpa.2001.118220
   Raivio T, 2012, J CLIN ENDOCR METAB, V97, pE694, DOI 10.1210/jc.2011-2938
   Reeves DL, 1941, B JOHNS HOPKINS HOSP, V69, P61
   Reidl S, 2002, HORM RES S3, V58, P16
   Ribeiro IM, 2007, EUR J OPHTHALMOL, V17, P104
   Rivkees SA, 2010, BRIT J OPHTHALMOL, V94, P1358, DOI 10.1136/bjo.2009.175851
   Rivkees SA, 2001, J PEDIATR-US, V139, P463, DOI 10.1067/mpd.2001.117074
   Rizzoti K, 2004, NAT GENET, V36, P247, DOI 10.1038/ng1309
   Schell-Apacik CC, 2008, AM J MED GENET A, V146A, P2501, DOI 10.1002/ajmg.a.32476
   Schwarz O, 1915, ARCH OPHTHALMOL-CHIC, V90, P326, DOI 10.1007/BF01858338
   Siatkowski RM, 1997, OPHTHALMOLOGY, V104, P493
   STROMLAND K, 1987, SURV OPHTHALMOL, V31, P277, DOI 10.1016/0039-6257(87)90028-2
   Svingen T, 2011, SEX DEV, V5, P294, DOI 10.1159/000335160
   Szabo N, 2011, PEDIATR NEUROL, V44, P420, DOI 10.1016/j.pediatrneurol.2011.01.002
   Tajima T, 2003, J CLIN ENDOCR METAB, V88, P45, DOI 10.1210/jc.2002-02818
   Taranova OV, 2006, GENE DEV, V20, P1187, DOI 10.1101/gad.1407906
   Tornqvist K, 2002, ACTA OPHTHALMOL SCAN, V80, P300, DOI 10.1034/j.1600-0420.2002.800313.x
   Vedin AM, 2012, HORM RES PAEDIAT, V77, P277, DOI 10.1159/000338330
   Weaver DR, 1998, J BIOL RHYTHM, V13, P100, DOI 10.1177/074873098128999952
   Webb EA, 2010, EUR J HUM GENET, V18, P393, DOI 10.1038/ejhg.2009.125
   WEST J, 1990, BRIT J OPHTHALMOL, V74, P511, DOI 10.1136/bjo.74.8.511-a
   WILLIAMS J, 1993, DEV MED CHILD NEUROL, V35, P490
   WILLIAMSON WD, 1987, CLIN PEDIATR, V26, P241, DOI 10.1177/000992288702600505
   WILSON DM, 1984, NEURORADIOLOGY, V26, P279
   ZEKI SM, 1991, BRIT J OPHTHALMOL, V75, P538, DOI 10.1136/bjo.75.9.538
NR 93
TC 2
Z9 2
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1092-8480
J9 CURR TREAT OPTION NE
JI Curr. Treat. Options Neurol.
PD FEB
PY 2013
VL 15
IS 1
BP 78
EP 89
DI 10.1007/s11940-012-0209-2
PG 12
WC Clinical Neurology
SC Neurosciences & Neurology
GA 077MG
UT WOS:000314031200007
PM 23233151
ER

PT J
AU Barber, JCK
   Hall, V
   Maloney, VK
   Huang, SW
   Roberts, AM
   Brady, AF
   Foulds, N
   Bewes, B
   Volleth, M
   Liehr, T
   Mehnert, K
   Bateman, M
   White, H
AF Barber, John C. K.
   Hall, Victoria
   Maloney, Viv K.
   Huang, Shuwen
   Roberts, Angharad M.
   Brady, Angela F.
   Foulds, Nicki
   Bewes, Beverley
   Volleth, Marianne
   Liehr, Thomas
   Mehnert, Karl
   Bateman, Mark
   White, Helen
TI 16p11.2-p12.2 duplication syndrome; a genomic condition differentiated
   from euchromatic variation of 16p11.2
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE chromosomes, human, pair 16; chromosome duplication; 16p11.2-p12.2; DNA
   array; euchromatic variant; copy number variation
ID MILD MENTAL-RETARDATION; COPY-NUMBER; MICRODELETION SYNDROME;
   DEVELOPMENTAL DELAY; TANDEM DUPLICATION; ARRAY CGH; AUTISM; DELETIONS;
   GENE; 16P
AB Chromosome 16 contains multiple copy number variations (CNVs) that predispose to genomic disorders. Here, we differentiate pathogenic duplications of 16p11.2-p12.2 from microscopically similar euchromatic variants of 16p11.2. Patient 1 was a girl of 18 with autism, moderate intellectual disability, behavioural difficulties, dysmorphic features and a 7.71-Mb (megabase pair) duplication (16:21 521 005-29 233 146). Patient 2 had a 7.81-Mb duplication (16:21 382 561-29 191 527), speech delay and obsessional behaviour as a boy and, as an adult, short stature, macrocephaly and mild dysmorphism. The duplications contain 65 coding genes of which Polo-like kinase 1 (PLK1) has the highest likelihood of being haploinsufficient and, by implication, a triplosensitive gene. An additional 1.11-Mb CNV of 10q11.21 in Patient 1 was a possible modifier containing the G-protein-regulated inducer of neurite growth 2 (GPRIN2) gene. In contrast, the euchromatic variants in Patients 3 and 4 were amplifications from a 945-kb region containing non-functional immunoglobulin heavy chain (IGHV), hect domain pseudogene (HERC2P4) and TP53-inducible target gene 3 (TP53TG3) loci in proximal 16p11.2 (16:31 953 353-32 898 635). Paralogous pyrosequencing gave a total copy number of 3-8 in controls and 8 to >10 in Patients 3 and 4. The 16p11.2-p12.2 duplication syndrome is a recurrent genomic disorder with a variable phenotype including developmental delay, dysmorphic features, mild to severe intellectual disability, autism, obsessive or stereotyped behaviour, short stature and anomalies of the hands and fingers. It is important to differentiate pathogenic 16p11.2-p12.2 duplications from harmless, microscopically similar euchromatic variants of proximal 16p11.2, especially at prenatal diagnosis. European Journal of Human Genetics (2013) 21, 182-189; doi:10.1038/ejhg.2012.144; published online 25 July 2012
C1 [Barber, John C. K.] Univ Southampton, Sch Med, Southampton Gen Hosp, Dept Human Genet & Genom Med,Fac Med, Southampton SO16 6YD, Hants, England.
   [Hall, Victoria; Huang, Shuwen; White, Helen] Salisbury NHS Fdn Trust, Natl Genet Reference Lab Wessex, Salisbury, Wilts, England.
   [Maloney, Viv K.; Bateman, Mark] Salisbury NHS Fdn Trust, Wessex Reg Genet Lab, Salisbury, Wilts, England.
   [Roberts, Angharad M.; Brady, Angela F.; Bewes, Beverley] Northwick Pk & St Marks Hosp, NW Thames Reg Genet Serv, Kennedy Galton Ctr, Harrow, Middx, England.
   [Foulds, Nicki] Univ Hosp Southampton NHS Fdn Trust, Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England.
   [Volleth, Marianne] Otto Von Guericke Univ, Inst Humangenet, Magdeburg, Germany.
   [Liehr, Thomas] Jena Univ Hosp, Inst Human Genet, Jena, Germany.
   [Mehnert, Karl] Genetikum Neu Ulm, Genet Beratung & Diagnost, Neu Ulm, Germany.
RP Barber, JCK (reprint author), Univ Southampton, Sch Med, Southampton Gen Hosp, Dept Human Genet & Genom Med,Fac Med, Tremona Rd, Southampton SO16 6YD, Hants, England.
EM john.barber@soton.ac.uk
FU UK Department of Health as part of the National Genetics Reference
   Laboratory (Wessex)
FX We thank all four families concerned as well as Dr Christine Garrett and
   Dr Kay MacDermot for their clinical input on Patient 1. We are grateful
   to Dr Petra Muschke (Magdeburg) for the information on Patient 3 and for
   contacting her for the second blood sampling. We thank Dr Ilona
   Dietze-Armana for sending information on Patient 4. We are also grateful
   to Professor Hunt Willard for the D16Z2 centromeric probe. VH, SH and HW
   were supported by the UK Department of Health as part of the National
   Genetics Reference Laboratory (Wessex).
CR Artuso R, 2011, J HUM GENET, V56, P508, DOI 10.1038/jhg.2011.50
   Bachmann-Gagescu R, 2010, GENET MED, V12, P641, DOI 10.1097/GIM.0b013e3181ef4286
   Ballif BC, 2007, NAT GENET, V39, P1071, DOI 10.1038/ng2107
   Barber JCK, 1999, HUM GENET, V104, P211, DOI 10.1007/s004390050938
   Barber JCK, 2008, EUR J HUM GENET, V16, P18, DOI 10.1038/sj.ejhg.5201932
   Barber JCK, 2005, J MED GENET, V42, P609, DOI 10.1136/jmg.2004.026955
   Barge-Schaapveld DQCM, 2011, AM J MED GENET A, V155A, P1066, DOI 10.1002/ajmg.a.33991
   Battaglia A, 2009, AM J MED GENET A, V149A, P1200, DOI 10.1002/ajmg.a.32847
   Behjati F, 2008, EUR J MED GENET, V51, P608, DOI 10.1016/j.ejmg.2008.06.007
   Bijlsma EK, 2009, EUR J MED GENET, V52, P77, DOI 10.1016/j.ejmg.2009.03.006
   Bourthomieu S, 2008, PRENATAL DIAG, V28, P254, DOI 10.1002/pd.1949
   COHEN MM, 1983, AM J MED GENET, V14, P89, DOI 10.1002/ajmg.1320140114
   Eichler EE, 1996, HUM MOL GENET, V5, P899, DOI 10.1093/hmg/5.7.899
   Engelen JJM, 2002, AM J MED GENET, V109, P149, DOI 10.1002/ajmg.10287
   Finelli P, 2004, J MED GENET, V41, DOI 10.1136/jmg.2003.016311
   Fode P, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016768
   Furrow A, 2011, AM J MED GENET A, V155A, P1972, DOI 10.1002/ajmg.a.33985
   Ghebranious N, 2007, AM J MED GENET A, V143A, P1462, DOI 10.1002/ajmg.a.31837
   Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
   Girirajan S, 2010, HUM MOL GENET, V19, pR176, DOI 10.1093/hmg/ddq366
   Guenthoer J, 2012, GENOME RES, V22, P232, DOI 10.1101/gr.117226.110
   Hall V, 2006, J MED GENET S1, V43, P326
   Hastings PJ, 2009, NAT REV GENET, V10, P551, DOI 10.1038/nrg2593
   Hempel M, 2009, AM J MED GENET A, V149A, P2106, DOI 10.1002/ajmg.a.33042
   Huang N, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001154
   Itsara A, 2009, AM J HUM GENET, V84, P148, DOI 10.1016/j.ajhg.2008.12.014
   Juan JLC, 1997, AM J MED GENET, V68, P219, DOI 10.1002/(SICI)1096-8628(19970120)68:2<219::AID-AJMG19>3.0.CO;2-X
   Li F, 2010, EUR J MED GENET, V53, P93, DOI 10.1016/j.ejmg.2010.01.004
   Pajares IL, 2006, PRENATAL DIAG, V26, P535, DOI 10.1002/pd.1454
   Ronaghi M, 1998, SCIENCE, V281, P363, DOI 10.1126/science.281.5375.363
   Tabet AC, 2012, EUR J HUM GENET, V20, P540, DOI 10.1038/ejhg.2011.244
   Walters RG, 2010, NATURE, V463, P671, DOI 10.1038/nature08727
   Wang HY, 2007, NATURE, V449, P96, DOI 10.1038/nature06056
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Whitby H, 2008, CYTOGENET GENOME RES, V123, P94, DOI 10.1159/000184696
NR 35
TC 7
Z9 8
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD FEB
PY 2013
VL 21
IS 2
BP 182
EP 189
DI 10.1038/ejhg.2012.144
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 077BQ
UT WOS:000314003300008
PM 22828807
ER

PT J
AU Field, LL
   Shumansky, K
   Ryan, J
   Truong, D
   Swiergala, E
   Kaplan, BJ
AF Field, L. L.
   Shumansky, K.
   Ryan, J.
   Truong, D.
   Swiergala, E.
   Kaplan, B. J.
TI Dense-map genome scan for dyslexia supports loci at 4q13, 16p12, 17q22;
   suggests novel locus at 7q36
SO GENES BRAIN AND BEHAVIOR
LA English
DT Article
DE ADHD; association analysis; autism; dyslexia genetics; family-based
   studies; gene mapping; genome scan; linkage analysis; overlapping
   predisposition; susceptibility
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SIB-PAIR ANALYSIS;
   READING-DISABILITY; SUSCEPTIBILITY LOCUS; DEVELOPMENTAL DYSLEXIA;
   LINKAGE DISEQUILIBRIUM; CANADIAN FAMILIES; GENETIC ETIOLOGY;
   HEPARAN-SULFATE; AUTISM
AB Analysis of genetic linkage to dyslexia was performed using 133,165 array-based SNPs genotyped in 718 persons from 101 dyslexia-affected families. Results showed five linkage peaks with lod scores >2.3 (4q13.1, 7q36.1-q36.2, 7q36.3, 16p12.1, and 17q22). Of these five regions, three have been previously implicated in dyslexia (4q13.1, 16p12.1, and 17q22), three have been implicated in attention-deficit hyperactivity disorder (ADHD, which highly co-occurs with dyslexia; 4q13.1, 7q36.3, 16p12.1) and four have been implicated in autism (a condition characterized by language deficits; 7q36.1-q36.2, 7q36.3, 16p12.1, and 17q22). These results highlight the reproducibility of dyslexia linkage signals, even without formally significant lod scores, and suggest dyslexia predisposing genes with relatively major effects and locus heterogeneity. The largest lod score (2.80) occurred at 17q22 within the MSI2 gene, involved in neuronal stem cell lineage proliferation. Interestingly, the 4q13.1 linkage peak (lod 2.34) occurred immediately upstream of the LPHN3 gene, recently reported both linked and associated with ADHD. Separate analyses of larger pedigrees revealed lods >2.3 at 13 regions per family; one family showed strong linkage (lod 2.9) to a known dyslexia locus (18p11) not detected in our overall data, demonstrating the value of analyzing single large pedigrees. Association analysis identified no SNPs with genome-wide significance, although a borderline significant SNP (P= 6 x107) occurred at 5q35.1 near FGF18, involved in laminar positioning of cortical neurons during development. We conclude that dyslexia genes with relatively major effects exist, are detectable by linkage analysis despite genetic heterogeneity, and show substantial overlapping predisposition with ADHD and autism.
C1 [Field, L. L.; Shumansky, K.; Ryan, J.; Truong, D.; Swiergala, E.] Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada.
   [Kaplan, B. J.] Univ Calgary, Dept Pediat, Calgary, AB T2N 1N4, Canada.
RP Field, LL (reprint author), BC Womens Hosp & Hlth Ctr, Dept Med Genet, Rm C234,4500 Oak St, Vancouver, BC V6H 3N1, Canada.
EM llfield@mail.ubc.ca
FU Canadian Institutes of Health Research [MT-15661]; Alberta Mental Health
   Research Fund; Alberta Children's Hospital Foundation; Canadian Genetic
   Diseases Network of Centres of Excellence Programme; BC Children's
   Hospital Foundation; Alberta Heritage Foundation for Medical Research
FX Supported by grants from the Canadian Institutes of Health Research
   (grant MT-15661 to L. L. F.), the Alberta Mental Health Research Fund
   (to B.J.K. and L. L. F.), Alberta Children's Hospital Foundation
   (B.J.K.), and the Canadian Genetic Diseases Network of Centres of
   Excellence Programme (L. L. F.), as well as a Senior Scientist Awards to
   L. L. F. from the BC Children's Hospital Foundation and the Alberta
   Heritage Foundation for Medical Research. We greatly appreciate the
   assistance of D. Fong in graphics preparation, and thank Affymetrix for
   generous assistance while our lab was a beta test site. The authors have
   no conflicts of interest to declare.
CR Abecasis GR, 2005, AM J HUM GENET, V77, P754, DOI 10.1086/497345
   Abecasis GR, 2002, NAT GENET, V30, P97, DOI 10.1038/ng786
   Arcos-Burgos M, 2004, AM J HUM GENET, V75, P998, DOI 10.1086/426154
   Arcos-Burgos M, 2010, MOL PSYCHIATR, V15, P1053, DOI 10.1038/mp.2010.6
   Auranen M, 2002, AM J HUM GENET, V71, P777, DOI 10.1086/342720
   Azim E, 2009, CEREB CORTEX, V19, pI62, DOI 10.1093/cercor/bhp030
   Bakker SC, 2003, AM J HUM GENET, V72, P1251, DOI 10.1086/375143
   BAKWIN H, 1973, DEV MED CHILD NEUROL, V15, P184
   Bates TC, 2007, EUR J HUM GENET, V15, P194, DOI 10.1038/sj.ejhg.5201739
   Bogliotti C, 2008, J EXP CHILD PSYCHOL, V101, P137, DOI 10.1016/j.jecp.2008.03.006
   Bradford Y, 2001, AM J MED GENET, V105, P539, DOI 10.1002/ajmg.1497
   Brkanac Z, 2008, BEHAV GENET, V38, P462, DOI 10.1007/s10519-008-9215-2
   Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
   Chen G, 2009, P NATL ACAD SCI USA, V106, P17613, DOI 10.1073/pnas.0909771106
   Cheng YL, 2010, DEVELOPMENT, V137, P519, DOI 10.1242/dev.027045
   Chin H, 2006, EXP MOL MED, V38, P144
   De Fries J. C., 1996, MENTAL RETARD DEV DI, V2, P39, DOI 10.1002/(SICI)1098-2779(1996)2:1<39::AID-MRDD7>3.0.CO;2-S
   DEFRIES JC, 1987, NATURE, V329, P537, DOI 10.1038/329537a0
   DEFRIES JC, 1989, J LEARN DISABIL, V22, P544
   Domene S, 2011, AM J MED GENET B, V156B, P11, DOI 10.1002/ajmg.b.31141
   Fagerheim T, 1999, J MED GENET, V36, P664
   Field LL, 1998, AM J HUM GENET, V63, P1448, DOI 10.1086/302107
   Fisher SE, 2002, NAT GENET, V30, P86, DOI 10.1038/ng792
   Flora A, 2009, SCIENCE, V326, P1424, DOI 10.1126/science.1181453
   Folstein SE, 1999, J CHILD PSYCHOL PSYC, V40, P1117, DOI 10.1017/S0021963099004461
   Francks C, 2002, PSYCHIATR GENET, V12, P35, DOI 10.1097/00041444-200203000-00005
   Gayan J, 2005, J CHILD PSYCHOL PSYC, V46, P1045, DOI 10.1111/j.1469-7610.2005.01447.x
   Gowan K, 2001, NEURON, V31, P219, DOI 10.1016/S0896-6273(01)00367-1
   Habib M, 2000, BRAIN, V123, P2373, DOI 10.1093/brain/123.12.2373
   Hasegawa H, 2004, J NEUROSCI, V24, P8711, DOI 10.1523/JNEUROSCI.3070-04.2004
   Hehr U, 2004, EUR J PEDIATR, V163, P347, DOI 10.1007/s00431-004-1459-0
   Holmans P, 1997, AM J HUM GENET, V60, P657
   Hsiung GYR, 2004, AM J MED GENET B, V125B, P112, DOI 10.1002/ajmg.b.20082
   Huang QQ, 2004, AM J HUM GENET, V75, P1106, DOI 10.1086/426000
   Inatani M, 2003, SCIENCE, V302, P1044, DOI 10.1126/science.1090497
   Palferman S, 2001, AM J HUM GENET, V69, P570
   Jain M, 2007, BIOL PSYCHIAT, V61, P1329, DOI 10.1016/j.biopsych.2006.06.026
   Jastak S, 1984, WIDE RANGE ACHIEVEME
   Jay P, 2000, EUR J BIOCHEM, V267, P2921, DOI 10.1046/j.1432-1327.2000.01306.x
   Jeong Y, 2008, NAT GENET, V40, P1348, DOI 10.1038/ng.230
   Kaminen N, 2003, J MED GENET, V40, P340, DOI 10.1136/jmg.40.5.340
   Kawase S, 2011, MOL BRAIN, V4, DOI 10.1186/1756-6606-4-14
   Klisch TJ, 2011, P NATL ACAD SCI USA, V108, P3288, DOI 10.1073/pnas.1100230108
   Kong A, 1997, AM J HUM GENET, V61, P1179, DOI 10.1086/301592
   LANDER E, 1995, NAT GENET, V11, P241, DOI 10.1038/ng1195-241
   Lauritsen MB, 2006, MOL PSYCHIATR, V11, P37, DOI 10.1038/sj.mp.4001754
   Leal SM, 2000, AM J HUM GENET, V66, P567, DOI 10.1086/302748
   Li H, 2006, MOL CELL NEUROSCI, V33, P136, DOI 10.1016/j.mcn.2006.06.012
   Lionel AC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002464
   Liu JJ, 2001, AM J HUM GENET, V69, P327, DOI 10.1086/321980
   Loo SK, 2004, MOL PSYCHIATR, V9, P485, DOI 10.1038/sj.mp.4001450
   Luciano M, 2011, TWIN RES HUM GENET, V14, P228, DOI 10.1375/twin.14.3.228
   Mangale VS, 2008, SCIENCE, V319, P304, DOI 10.1126/science.1151695
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Meaburn EL, 2008, MOL PSYCHIATR, V13, P729, DOI 10.1038/sj.mp.4002063
   Nishimura T, 2009, NEUROSCIENCE, V159, P427, DOI 10.1016/j.neuroscience.2009.01.022
   Ogdie MN, 2004, AM J HUM GENET, V75, P661, DOI 10.1086/424387
   Ohuchi H, 2000, MECH DEVELOP, V95, P55, DOI 10.1016/S0925-4773(00)00331-2
   OLSON R, 1989, J LEARN DISABIL, V22, P339
   Petryshen TL, 2002, J MED GENET, V39, P125, DOI 10.1136/jmg.39.2.125
   Philippi A, 2005, MOL PSYCHIATR, V10, P950, DOI 10.1038/sj.mp.4001704
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Ramus F, 2003, BRAIN, V126, P841, DOI 10.1093/brain/awg076
   Raskind WH, 2005, MOL PSYCHIATR, V10, P699, DOI 10.1038/sj.mp.4001657
   Ribases M, 2011, GENES BRAIN BEHAV, V10, P149, DOI 10.1111/j.1601-183X.2010.00649.x
   ROSNER J, 1971, J LEARN DISABIL, V4, P384
   Sakakibara S, 2002, P NATL ACAD SCI USA, V99, P15194, DOI 10.1073/pnas.232087499
   Schmidt GL, 2008, J CLIN EXP NEUROPSYC, V30, P557, DOI 10.1080/13803390701551225
   Sen B, 2010, GENES BRAIN BEHAV, V9, P248, DOI 10.1111/j.1601-183X.2009.00556.x
   Shaywitz SE, 2005, BIOL PSYCHIAT, V57, P1301, DOI 10.1016/j.biopsych.2005.01.043
   SHAYWITZ SE, 1990, JAMA-J AM MED ASSOC, V264, P998, DOI 10.1001/jama.264.8.998
   Spreen O., 1988, LEARNING DISABLED CH
   Tzenova J, 2004, AM J MED GENET B, V127B, P117, DOI 10.1002/ajmg.b.20139
   Van Orden G. C., 1996, DEV DYSLEXIA NEURAL, P185
   Wadsworth SJ, 2010, BEHAV GENET, V40, P751, DOI 10.1007/s10519-010-9349-x
   Wechsler D, 1981, WECHSLER ADULT INTEL
   Wechsler D., 1974, MANUAL WECHSLER INTE
   Willcutt EG, 2000, J LEARN DISABIL, V33, P179, DOI 10.1177/002221940003300206
   Willcutt EG, 2007, AM J MED GENET B, V144B, P709, DOI 10.1002/ajmg.b.30310
   Woodcock R., 1987, WOODCOCK READING MAS
   Woodcock R. W., 1989, WOODCOCK JOHNSON PSY
   Yabe T, 2005, GLYCOBIOLOGY, V15, P982, DOI 10.1093/glycob/cwi090
NR 82
TC 9
Z9 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1601-1848
J9 GENES BRAIN BEHAV
JI Genes Brain Behav.
PD FEB
PY 2013
VL 12
IS 1
BP 56
EP 69
DI 10.1111/gbb.12003
PG 14
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 076YG
UT WOS:000313994500007
PM 23190410
ER

PT J
AU Bauminger-Zvieli, N
   Kugelmass, DS
AF Bauminger-Zvieli, Nirit
   Kugelmass, Dana Shoham
TI Mother-Stranger Comparisons of Social Attention in Jealousy Context and
   Attachment in HFASD and Typical Preschoolers
SO JOURNAL OF ABNORMAL CHILD PSYCHOLOGY
LA English
DT Article
DE Jealousy; HFASD; Emotional expression; Attachment
ID MATERNAL SENSITIVITY; YOUNG-CHILDREN; Q-SORT; AUTISM; SECURITY;
   BEHAVIOR; DISORDERS; INFANTS; ASD; AGE
AB Affective bonding, social attention, and intersubjective capabilities are all conditions for jealousy, and are deficient in autism. Thus, examining jealousy and attachment may elucidate the socioemotional deficit in autism spectrum disorders (ASD). Jealousy was provoked in 30 high-functioning children with ASD (HFASD) and 30 typical children (ages 3-6 years) through two triadic social (storybook-reading) scenarios - mother-child-rival and stranger-child-rival. A control nonsocial scenario included mother/stranger-book. For both groups, higher jealousy expressions emerged for mother than stranger, and for social than nonsocial scenarios. Attachment security (using Attachment Q-Set) was lower for HFASD than typical groups, but attachment correlated negatively with jealous verbalizations for both groups and with jealous eye gazes for HFASD. Implications for understanding jealousy's developmental complexity and the socioemotional deficit in ASD are discussed.
C1 [Bauminger-Zvieli, Nirit; Kugelmass, Dana Shoham] Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
RP Bauminger-Zvieli, N (reprint author), Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel.
EM nirit.bauminger@biu.ac.il
CR Ainsworth M. S., 1978, PATTERNS ATTACHMENT
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Atkinson L, 1999, MONOGR SOC RES CHILD, V64, P45, DOI 10.1111/1540-5834.00033
   Bauminger N, 2008, COGNITION EMOTION, V22, P595, DOI 10.1080/02699930701439986
   Bauminger N, 2004, DEV PSYCHOPATHOL, V16, P157, DOI 10.1017/S0954579404044451
   Bowlby J., 1969, ATTACHMENT LOSS, V1
   Cassidy J., 2008, HDB ATTACHMENT THEOR, P3
   Centers for Disease Control and Prevention, 2009, MORBIDITY MORTALITY, V58
   Clark SE, 2000, INFANT CHILD DEV, V9, P91, DOI 10.1002/1522-7219(200006)9:2<91::AID-ICD218>3.3.CO;2-F
   Clifford S, 2009, J AUTISM DEV DISORD, V39, P1369, DOI 10.1007/s10803-009-0748-x
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   WATERS E, 1985, MONOGR SOC RES CHILD, V50, P41, DOI 10.2307/3333826
   Dissanayake C, 1996, J CHILD PSYCHOL PSYC, V37, P149, DOI 10.1111/j.1469-7610.1996.tb01386.x
   Hart S. L., 2008, INT C INF STUD VANC
   Hobson R. P., 2006, MONOGRAPHS SOC RES C, V71
   Kanner L, 1943, NERV CHILD, V2, P217
   Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   MASCIUCH S, 1993, J SOC PERS RELAT, V10, P421, DOI 10.1177/0265407593103008
   Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y
   Miller AL, 2000, SOC DEV, V9, P433, DOI 10.1111/1467-9507.00137
   MORAN G, 1992, INFANT BEHAV DEV, V15, P427, DOI 10.1016/0163-6383(92)80011-I
   Mullen E., 1997, MULLEN SCALES EARLY
   ROGERS SJ, 1993, J AM ACAD CHILD PSY, V32, P1274, DOI 10.1097/00004583-199311000-00023
   Rutgers A. H., 2007, AUTISM, V11, P87
   Rutgers AH, 2004, J CHILD PSYCHOL PSYC, V45, P1123, DOI 10.1111/j.1469-7610.2004.t01-1-00305.x
   Swettenham J, 1998, J CHILD PSYCHOL PSYC, V39, P747, DOI 10.1017/S0021963098002595
   Tessier R, 2002, SOC DEV, V11, P147, DOI 10.1111/1467-9507.00192
   TETI DM, 1989, CHILD DEV, V60, P1519, DOI 10.1111/j.1467-8624.1989.tb04022.x
   van Ijzendoorn MH, 2004, CHILD DEV, V75, P1188, DOI 10.1111/j.1467-8624.2004.00733.x
   Volling BL, 2002, CHILD DEV, V73, P581, DOI 10.1111/1467-8624.00425
   Waterhouse L., 1998, AUTISM PERVASIVE DEV, P242
   Waters E., 2009, ASSESSING SECU UNPUB
   Wechsler D., 1989, MANUAL WECHSLER PRES
   Wechsler D., 1995, WISC R 95 MANUAL WEC
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
NR 37
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0091-0627
J9 J ABNORM CHILD PSYCH
JI J. Abnorm. Child Psychol.
PD FEB
PY 2013
VL 41
IS 2
BP 253
EP 264
DI 10.1007/s10802-012-9664-1
PG 12
WC Psychology, Clinical; Psychology, Developmental
SC Psychology
GA 078IY
UT WOS:000314093200006
PM 22821449
ER

PT J
AU Tonnsen, BL
   Malone, PS
   Hatton, DD
   Roberts, JE
AF Tonnsen, Bridgette L.
   Malone, Patrick S.
   Hatton, Deborah D.
   Roberts, Jane E.
TI Early Negative Affect Predicts Anxiety, not Autism, in Preschool Boys
   with Fragile X Syndrome
SO JOURNAL OF ABNORMAL CHILD PSYCHOLOGY
LA English
DT Article
DE Fragile X syndrome; Anxiety; Autism; Temperament; Longitudinal
ID PARENT-CHILD INTERACTIONS; PRADER-WILLI-SYNDROME; SPECTRUM DISORDER;
   MENTAL-RETARDATION; BEHAVIOR PROBLEMS; SOCIAL-BEHAVIOR; YOUNG-CHILDREN;
   DEVELOPMENTAL TRAJECTORIES; PSYCHIATRIC-DISORDERS; IDIOPATHIC AUTISM
AB Children with fragile X syndrome (FXS) face high risk for anxiety disorders, yet no studies have explored FXS as a high-risk sample for investigating early manifestations of anxiety outcomes. Negative affect is one of the most salient predictors of problem behaviors and has been associated with both anxiety and autistic outcomes in clinical and non-clinical pediatric samples. In light of the high comorbidity between autism and anxiety within FXS, the present study investigates the relationship between longitudinal trajectories of negative affect (between 8 and 71 months) and severity of anxiety and autistic outcomes in young males with FXS (n = 25). Multilevel models indicated associations between elevated anxiety and higher fear and sadness, lower soothability, and steeper longitudinal increases in approach. Autistic outcomes were unrelated to negative affect. These findings suggest early negative affect differentially predicts anxiety, not autistic symptoms, within FXS. Future research is warranted to determine the specificity of the relationship between negative affect and anxiety, as well as to explore potential moderators. Characterizing the relationship between early negative affect and anxiety within FXS may inform etiology and treatment considerations specific to children with FXS, as well as lend insight into precursors of anxiety disorders in other clinical groups and community samples.
C1 [Tonnsen, Bridgette L.; Malone, Patrick S.; Roberts, Jane E.] Univ S Carolina, Dept Psychol, Columbia, SC 29208 USA.
   [Hatton, Deborah D.; Roberts, Jane E.] Univ N Carolina, FPG Res Inst, Chapel Hill, NC USA.
RP Roberts, JE (reprint author), Univ S Carolina, Dept Psychol, 1512 Pendleton St, Columbia, SC 29208 USA.
EM Jane.Roberts@sc.edu
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
   Achenbach TM, 1991, MANUAL CHILD BEHAV C
   Achenbach TM, 2003, J CLIN CHILD ADOLESC, V32, P328, DOI 10.1207/S15374424JCCP3203_02
   Akshoomoff N, 2006, CHILD NEUROPSYCHOL, V12, P269, DOI 10.1080/09297040500473714
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bailey DB, 2008, AM J MED GENET A, V146A, P2060, DOI 10.1002/ajmg.a.32439
   Bailey DB, 2000, J AUTISM DEV DISORD, V30, P49
   Bailey DB, 2001, J AUTISM DEV DISORD, V31, P165
   Bailey DB, 2008, AM J MED GENET A, V146A, P720, DOI 10.1002/ajmg.a.32240
   Bailey Jr D. B., 2008, PEDIATRICS, V121, P693
   Bargagna S, 2002, PANMINERVA MED, V44, P7
   Barlow DH, 2000, AM PSYCHOL, V55, P1247, DOI 10.1037//0003-066X.55.11.1247
   Barlow DH., 1988, ANXIETY ITS DISORDER
   Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
   Bolte S, 1999, PSYCHOPATHOLOGY, V32, P93, DOI 10.1159/000029072
   Boyle L, 2010, AM J MED GENET C, V154C, P469, DOI 10.1002/ajmg.c.30277
   Brian J, 2008, AUTISM, V12, P433, DOI 10.1177/1362361308094500
   Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
   Budimirovic DB, 2011, DEV NEUROSCI-BASEL, V33, P379, DOI 10.1159/000330213
   Budimirovic DB, 2006, AM J MED GENET A, V140A, P1814, DOI 10.1002/ajmg.a.31405
   Buss K., 2009, SOCIAL DEV, V19, P304
   Calkins SD, 2007, DEV PSYCHOPATHOL, V19, P675, DOI 10.1017/S095457940700034X
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Chaplin TM, 2005, EMOTION, V5, P80, DOI 10.1037/1528-3542.5.1.80
   COLE PM, 1994, DEV PSYCHOL, V30, P835, DOI 10.1037/0012-1649.30.6.835
   Constantino J. N., 2011, PEDIATR RES, V69, P55, DOI DOI 10.1203/PDR.0B013E318212EC6E
   Cordeiro L, 2011, J NEURODEV DISORD, V3, P57, DOI 10.1007/s11689-010-9067-y
   Costello EJ, 2003, ARCH GEN PSYCHIAT, V60, P837, DOI 10.1001/archpsyc.60.8.837
   Crawford DC, 2002, AM J MED GENET, V110, P226, DOI 10.1002/ajmg.10427
   Crawford DC, 2001, GENET MED, V3, P359, DOI 10.1097/00125817-200109000-00006
   Duke BJ, 2008, MED HYPOTHESES, V71, P212, DOI 10.1016/j.mehy.2008.03.037
   Dykens EM, 1997, AM J MENT RETARD, V102, P228, DOI 10.1352/0895-8017(1997)102<0228:MBICWP>2.0.CO;2
   Ebesutani C, 2010, J PSYCHOPATHOL BEHAV, V32, P373, DOI 10.1007/s10862-009-9174-9
   Eisenberg N, 2001, CHILD DEV, V72, P1112, DOI 10.1111/1467-8624.00337
   Esbensen AJ, 2003, J AUTISM DEV DISORD, V33, P617, DOI 10.1023/B:JADD.0000005999.27178.55
   Garon N, 2009, J ABNORM CHILD PSYCH, V37, P59, DOI 10.1007/s10802-008-9258-0
   Gartstein MA, 2010, DEV PSYCHOL, V46, P651, DOI 10.1037/a0018898
   Goldsmith HH, 1996, CHILD DEV, V67, P218, DOI 10.1111/j.1467-8624.1996.tb01730.x
   Grant VV, 2009, CAN J PSYCHIAT, V54, P320
   Hall S, 2006, J AUTISM DEV DISORD, V36, P935, DOI 10.1007/s10803-006-0132-z
   Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001
   Hall SS, 2009, DEV DISABIL RES REV, V15, P353, DOI 10.1002/ddrr.78
   Hall SS, 2009, J AM ACAD CHILD PSY, V48, P320, DOI 10.1097/CHI.0b013e318195bd15
   Hall SS, 2008, J ABNORM CHILD PSYCH, V36, P927, DOI 10.1007/s10802-008-9223-y
   Hatton DD, 1999, DEV MED CHILD NEUROL, V41, P625, DOI 10.1017/S0012162299001280
   Hatton DD, 2009, AJIDD-AM J INTELLECT, V114, P161, DOI 10.1352/1944-7558-114.3.161
   Hatton DD, 2003, AM J MENT RETARD, V108, P373, DOI 10.1352/0895-8017(2003)108<373:ABICWF>2.0.CO;2
   Hatton DD, 2006, AM J MED GENET A, V140A, P1804, DOI 10.1002/ajmg.a.31286
   Hatton DD, 2002, AM J MED GENET, V108, P105, DOI 10.1002/ajmg.10216
   Hazlett HC, 2009, J NEURODEV DISORD, V1, P81, DOI 10.1007/s11689-009-9009-8
   Hernandez RN, 2009, AM J MED GENET A, V149A, P1125, DOI 10.1002/ajmg.a.32848
   Hessl D, 2004, MENT RETARD DEV D R, V10, P17, DOI 10.1002/mrdd.20004
   Hessl D, 2006, J CHILD PSYCHOL PSYC, V47, P602, DOI 10.1111/j.1469-7610.2005.01556.x
   Hessl D, 2002, PSYCHONEUROENDOCRINO, V27, P855, DOI 10.1016/S0306-4530(01)00087-7
   Hoeft F, 2011, ARCH GEN PSYCHIAT, V68, P295, DOI 10.1001/archgenpsychiatry.2010.153
   Holmboe K., 2010, GENES BRAIN BEHAV, V10
   Hooper SR, 2008, NEUROPSYCHOLOGY, V22, P36, DOI 10.1037/0894-4105.22.1.36
   Hudson JL, 2002, J CLIN CHILD ADOLESC, V31, P548
   Hudson JL, 2001, BEHAV RES THER, V39, P1411, DOI 10.1016/S0005-7967(00)00107-8
   Hutman T, 2010, J CHILD PSYCHOL PSYC, V51, P1010, DOI 10.1111/j.1469-7610.2010.02270.x
   KAGAN J, 1987, CHILD DEV, V58, P1459, DOI 10.1111/j.1467-8624.1987.tb03858.x
   Kau ASM, 2004, AM J MED GENET A, V126A, P9, DOI 10.1002/ajmg.a.20218
   Kau ASM, 2000, AM J MENT RETARD, V105, P286, DOI 10.1352/0895-8017(2000)105<0286:EBSOPP>2.0.CO;2
   Kaufmann WE, 2004, AM J MED GENET A, V129A, P225, DOI 10.1002/ajmg.a.30229
   Kessler RC, 2007, CURR OPIN PSYCHIATR, V20, P359, DOI 10.1097/YCO.0b013e32816ebc8c
   KESSLER RC, 1994, ARCH GEN PSYCHIAT, V51, P8
   Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
   Lemery KS, 2002, CHILD DEV, V73, P867, DOI 10.1111/1467-8624.00444
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   Martin EI, 2010, CLIN LAB MED, V30, P865, DOI 10.1016/j.cll.2010.07.006
   McDuffie A, 2010, AJIDD-AM J INTELLECT, V115, P307, DOI 10.1352/1944-7558-115.4.307
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Mullen E, 1995, MULLEN SCALES EARLY
   Munson J, 2008, AM J MENT RETARD, V113, P439, DOI 10.1352/2008.113:439-452
   Muthen L. K., 2010, MPLUS USERS GUIDE
   Nakamura BJ, 2009, J PSYCHOPATHOL BEHAV, V31, P178, DOI 10.1007/s10862-008-9119-8
   Ozonoff S., 2011, PEDIATRICS
   Pilowsky T, 1998, J AUTISM DEV DISORD, V28, P143, DOI 10.1023/A:1026092632466
   Putnam SP, 2005, CHILD DEV, V76, P212, DOI 10.1111/j.1467-8624.2005.00840.x
   Putnam SP, 2008, INFANT CHILD DEV, V17, P387, DOI 10.1002/ICD.582
   Putnam SP, 2006, INFANT BEHAV DEV, V29, P386, DOI 10.1016/j.infbeh.2006.01.004
   Raudenbush Stephen W., 2002, HIERARCHAL LINEAR MO
   Roberts J. E., 2011, J AUTISM DEV DISORDE
   Roberts JE, 2009, AM J MED GENET B, V150B, P130, DOI 10.1002/ajmg.b.30786
   Roberts JE, 2001, DEV PSYCHOBIOL, V39, P107, DOI 10.1002/dev.1035
   Roberts JE, 2009, J PEDIATR PSYCHOL, V34, P827, DOI 10.1093/jpepsy/jsn129
   Roberts JE, 2007, J AUTISM DEV DISORD, V37, P1748, DOI 10.1007/s10803-006-0305-9
   Roberts JE, 2006, J DEV BEHAV PEDIATR, V27, P193, DOI 10.1097/00004703-200606000-00003
   Roberts JE, 2012, AJIDD-AM J INTELLECT, V117, P90, DOI 10.1352/1944-7558-117.2.90
   Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409
   Rothbart MK, 2003, J PERS, V71, P1113, DOI 10.1111/1467-6494.7106009
   ROTHBART MK, 1981, CHILD DEV, V52, P569, DOI 10.1111/j.1467-8624.1981.tb03082.x
   Rothbart MK, 2001, CHILD DEV, V72, P1394, DOI 10.1111/1467-8624.00355
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Schopler E., 1998, CHILDHOOD AUTISM RAT
   Shaffer D, 1996, J AM ACAD CHILD PSY, V35, P865, DOI 10.1097/00004583-199607000-00012
   Shanahan M, 2008, J INTELL DISABIL RES, V52, P842, DOI 10.1111/j.1365-2788.2008.01074.x
   Sheese Brad E, 2009, Cogn Neuropsychiatry, V14, P332, DOI 10.1080/13546800902844064
   Silverman W. K., 2004, ANXIETY DISORDERS IN
   Singer J. D., 2003, APPL LONGITUDINAL DA
   Singer JD, 1998, J EDUC BEHAV STAT, V23, P323
   Sullivan K, 2007, J INTELL DISABIL RES, V51, P54, DOI 10.1111/j.1365-2788.2006.00899.x
   van Lieshout CFM, 1998, J PEDIATR PSYCHOL, V23, P111, DOI 10.1093/jpepsy/23.2.111
   Volkmar FR, 2011, DEV PSYCHOBIOL, V53, P428, DOI 10.1002/dev.20556
   Watson LR, 2007, J AUTISM DEV DISORD, V37, P49, DOI 10.1007/s10803-006-0334-4
   Weis R, 2002, J PERS SOC PSYCHOL, V83, P216, DOI 10.1037//0022-3514.83.1.216
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   Yoder P, 2009, J AUTISM DEV DISORD, V39, P1381, DOI 10.1007/s10803-009-0753-0
   Zingerevich C, 2009, J INTELL DISABIL RES, V53, P11, DOI 10.1111/j.1365-2788.2008.01107.x
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 110
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0091-0627
J9 J ABNORM CHILD PSYCH
JI J. Abnorm. Child Psychol.
PD FEB
PY 2013
VL 41
IS 2
BP 267
EP 280
DI 10.1007/s10802-012-9671-2
PG 14
WC Psychology, Clinical; Psychology, Developmental
SC Psychology
GA 078IY
UT WOS:000314093200007
PM 23011214
ER

PT J
AU Mayo, J
   Chlebowski, C
   Fein, DA
   Eigsti, IM
AF Mayo, Jessica
   Chlebowski, Colby
   Fein, Deborah A.
   Eigsti, Inge-Marie
TI Age of First Words Predicts Cognitive Ability and Adaptive Skills in
   Children with ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Autism spectrum disorders; Language acquisition; Language delay;
   Developmental milestones; Prognosis
ID AUTISM SPECTRUM DISORDERS; PERVASIVE DEVELOPMENTAL DISORDERS; MODIFIED
   CHECKLIST; DIAGNOSTIC INTERVIEW; LANGUAGE-DEVELOPMENT;
   ASPERGER-SYNDROME; YOUNG-CHILDREN; TODDLERS; COMMUNICATION; DELAYS
AB Acquiring useful language by age 5 has been identified as a strong predictor of positive outcomes in individuals with Autism Spectrum Disorders (ASD). This study examined the relationship between age of language acquisition and later functioning in children with ASD (n = 119). First word acquisition at a range of ages was probed for its relationship to cognitive ability and adaptive behaviors at 52 months. Results indicated that although producing first words predicted better outcome at every age examined, producing first words by 24 months was a particularly strong predictor of better outcomes. This finding suggests that the historic criterion for positive prognosis (i.e., "useful language by age 5") can be updated to a more specific criterion with an earlier developmental time point.
C1 [Mayo, Jessica; Chlebowski, Colby; Fein, Deborah A.; Eigsti, Inge-Marie] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA.
RP Mayo, J (reprint author), Univ Connecticut, Dept Psychol, 406 Babbidge Rd,U-1020, Storrs, CT 06269 USA.
EM jessica.mayo@uconn.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Buschmann A, 2008, DEV MED CHILD NEUROL, V50, P223, DOI 10.1111/j.1469-8749.2008.02034.x
   Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
   Chlebowski C, 2010, J AUTISM DEV DISORD, V40, P787, DOI 10.1007/s10803-009-0926-x
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Dawson G., 1997, EFFECTIVENESS EARLY, P307
   De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
   Devescovi A, 2005, J CHILD LANG, V32, P759, DOI 10.1017/S0305000905007105
   Eigsti IM, 2007, J AUTISM DEV DISORD, V37, P1007, DOI 10.1007/s10803-006-0239-2
   EISENBERG L, 1956, AM J PSYCHIAT, V112, P607
   Ellis Weismer S., 2000, SPEECH LANGUAGE IMPA, P157
   Fenson Larry, 1994, Monographs of the Society for Research in Child Development, V59, P1
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   FRITH U, 1994, PHILOS T ROY SOC B, V346, P97, DOI 10.1098/rstb.1994.0133
   Gillespie-Lynch K, 2012, J AUTISM DEV DISORD, V42, P161, DOI 10.1007/s10803-011-1222-0
   Girolametto L, 1996, J SPEECH HEAR RES, V39, P1274
   Goldstein H, 2002, J AUTISM DEV DISORD, V32, P373, DOI 10.1023/A:1020589821992
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Happe F, 1996, BRAIN, V119, P1377, DOI 10.1093/brain/119.4.1377
   Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
   Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Hus V, 2011, J CHILD PSYCHOL PSYC, V52, P753, DOI 10.1111/j.1469-7610.2011.02398.x
   KANNER L, 1972, J AUTISM CHILD SCHIZ, V2, P9, DOI 10.1007/BF01537624
   Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
   Koegel R. L., 1988, GEN MAINTENANCE LIFE, P41
   Leonard L. B., 2000, SPEECH LANGUAGE IMPA, P195
   Levy A, 2011, RES AUTISM SPECT DIS, V5, P1271, DOI 10.1016/j.rasd.2011.01.023
   Lord C, 2004, DEVELOPMENTAL LANGUAGE DISORDERS: FROM PHENOTYPES TO ETIOLOGIES, P7
   Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   VENTER A, 1992, J CHILD PSYCHOL PSYC, V33, P489, DOI 10.1111/j.1469-7610.1992.tb00887.x
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Marchman V. A., 2008, DEVELOPMENTAL SCI, V11, P9
   Matson JL, 2010, RES AUTISM SPECT DIS, V4, P626, DOI 10.1016/j.rasd.2009.12.006
   Mullen E., 1997, MULLEN SCALES EARLY
   Ozonoff S, 2005, AUTISM, V9, P461, DOI 10.1177/1362361305057880
   Paparella T, 2011, J COMMUN DISORD, V44, P569, DOI 10.1016/j.jcomdis.2011.08.002
   Paul R., 1996, AM J SPEECH-LANG PAT, V5, P5
   Rapin I, 1997, Semin Pediatr Neurol, V4, P86, DOI 10.1016/S1071-9091(97)80024-1
   Rapin I, 2003, BRAIN DEV-JPN, V25, P166, DOI 10.1016/S0387-7604(02)00191-2
   Rescorla L, 2001, J SPEECH LANG HEAR R, V44, P434, DOI 10.1044/1092-4388(2001/035)
   Robins D., 1999, MODIFIED CHECKLIST A
   Robins D. L., 1999, FOLLOW INTERVIEW MOD
   Robins DL, 2006, J DEV BEHAV PEDIATR, V27, pS111, DOI 10.1097/00004703-200604002-00009
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Robins DL, 2008, AUTISM, V12, P537, DOI 10.1177/1362361308094502
   RUTTER M, 1970, SEMIN PSYCHIAT, V2, P435
   Schopler E., 1988, W PSYCHOL SERVICES
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   SHORT AB, 1988, J AUTISM DEV DISORD, V18, P207, DOI 10.1007/BF02211947
   Shumway S, 2009, J SPEECH LANG HEAR R, V52, P1139, DOI 10.1044/1092-4388(2009/07-0280)
   Siperstein R, 2004, J AUTISM DEV DISORD, V34, P731, DOI 10.1007/s10803-004-5294-y
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Stevens MC, 2000, J AM ACAD CHILD PSY, V39, P346, DOI 10.1097/00004583-200003000-00017
   Stone WL, 1997, J AUTISM DEV DISORD, V27, P677, DOI 10.1023/A:1025854816091
   Stone WL, 2000, J AUTISM DEV DISORD, V30, P607, DOI 10.1023/A:1005647629002
   Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136)
   Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
   Zubrick SR, 2007, J SPEECH LANG HEAR R, V50, P1562, DOI 10.1044/1092-4388(2007/106)
NR 62
TC 9
Z9 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 253
EP 264
DI 10.1007/s10803-012-1558-0
PG 12
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600001
PM 22673858
ER

PT J
AU Westphal, A
   Schelinski, S
   Volkmar, F
   Pelphrey, K
AF Westphal, Alexander
   Schelinski, Stefanie
   Volkmar, Fred
   Pelphrey, Kevin
TI Revisiting Regression in Autism: Heller's Dementia Infantilis Includes A
   Translation of Uber Dementia Infantilis
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Childhood disintegrative disorder; Regression
ID CHILDHOOD DISINTEGRATIVE DISORDER
AB Theodor Heller first described a severe regression of adaptive function in normally developing children, something he termed dementia infantilis, over one 100 years ago. Dementia infantilis is most closely related to the modern diagnosis, childhood disintegrative disorder. We translate Heller's paper, ber Dementia Infantilis, and discuss similarities in presentation between Heller's cases, and a group of children with childhood disintegrative disorder. In particular we discuss a prodromal period of affective dysregulation described by Heller, and also evident in our sample, but not previously described in any detail since the publication of ber Dementia Infantilis.
C1 [Westphal, Alexander; Schelinski, Stefanie; Volkmar, Fred; Pelphrey, Kevin] Yale Child Study Ctr, New Haven, CT 06519 USA.
   [Westphal, Alexander] Yale Univ, Dept Law & Psychiat, New Haven, CT 06519 USA.
   [Schelinski, Stefanie] Max Planck Inst Human Cognit & Brain Sci, D-04103 Leipzig, Germany.
RP Westphal, A (reprint author), Yale Child Study Ctr, New Haven, CT 06519 USA.
EM Alexander.Westphal@yale.edu
CR Heller Theodore, 1908, Z ERFORSCH BEHANDL J, V2, P17
   Kurita H, 2004, EUR CHILD ADOLES PSY, V13, P221, DOI 10.1007/s00787-004-0397-8
   Lotz D, 2000, LEBENSBILDER BEDEUTE, P111
   Malhotra S, 2002, EUR CHILD ADOLES PSY, V11, P108, DOI 10.1007/s00787-002-0270-6
NR 4
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 265
EP 271
DI 10.1007/s10803-012-1559-z
PG 7
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600002
PM 22677931
ER

PT J
AU Pfeifer, JH
   Merchant, JS
   Colich, NL
   Hernandez, LM
   Rudie, JD
   Dapretto, M
AF Pfeifer, Jennifer H.
   Merchant, Junaid S.
   Colich, Natalie L.
   Hernandez, Leanna M.
   Rudie, Jeff D.
   Dapretto, Mirella
TI Neural and Behavioral Responses During Self-Evaluative Processes Differ
   in Youth With and Without Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Self; Ventral mPFC; Anterior insula; Middle cingulate cortex;
   Development
ID SPECTRUM DISORDER; AUTOBIOGRAPHICAL MEMORY; FUNCTIONAL CONNECTIVITY;
   DIAGNOSTIC INTERVIEW; PERSPECTIVE-TAKING; PREFRONTAL CORTEX; SOCIAL
   COGNITION; CINGULATE CORTEX; NETWORK ANALYSIS; ANTERIOR INSULA
AB This fMRI study investigated neural responses while making appraisals of self and other, across the social and academic domains, in children and adolescents with and without autism spectrum disorders (ASD). Compared to neurotypical youth, those with ASD exhibited hypoactivation of ventromedial prefrontal cortex during self-appraisals. Responses in middle cingulate cortex (MCC) and anterior insula (AI) also distinguished between groups. Stronger activity in MCC and AI during self-appraisals was associated with better social functioning in the ASD group. Although self-appraisals were significantly more positive in the neurotypical group, positivity was unrelated to brain activity in these regions. Together, these results suggest that multiple brain regions support making self-appraisals in neurotypical development, and function atypically in youth with ASD.
C1 [Pfeifer, Jennifer H.; Merchant, Junaid S.] 1227 Univ Oregon, Dept Psychol, Eugene, OR 97403 USA.
   [Colich, Natalie L.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
   [Colich, Natalie L.; Hernandez, Leanna M.; Dapretto, Mirella] Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA.
   [Rudie, Jeff D.] Univ Calif Los Angeles, David Geffen Sch Med, Neurosci Interdept Program, Los Angeles, CA 90095 USA.
   [Dapretto, Mirella] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Autism Res & Treatment, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.
   [Dapretto, Mirella] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
   [Dapretto, Mirella] Univ Calif Los Angeles, FPR UCLA Ctr Culture Brain & Dev, Los Angeles, CA USA.
RP Pfeifer, JH (reprint author), 1227 Univ Oregon, Dept Psychol, Eugene, OR 97403 USA.
EM jpfeifer@uoregon.edu
CR Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067
   Berndt T. J., 1996, HDB SELF CONCEPT, P171
   Bracken B. A., 1996, HDB SELF CONCEPT
   BROWN JD, 1986, SOC COGNITION, V4, P353, DOI 10.1521/soco.1986.4.4.353
   Bruck M, 2007, DEV PSYCHOPATHOL, V19, P73, DOI 10.1017/S0954579407070058
   Chen AC, 2010, NEUROIMAGE, V51, P930, DOI 10.1016/j.neuroimage.2010.02.044
   Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c
   Chiu PH, 2008, NEURON, V57, P463, DOI 10.1016/j.neuron.2007.12.020
   Coie J. D., 1993, CURRENT DIRECTIONS P, V2, P89, DOI 10.1111/1467-8721.ep10770946
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Craig AD, 2009, NAT REV NEUROSCI, V10, P59, DOI 10.1038/nrn2555
   Crane L, 2008, J AUTISM DEV DISORD, V38, P498, DOI 10.1007/s10803-007-0420-2
   Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
   Friston KJ, 1999, NEUROIMAGE, V10, P385, DOI 10.1006/nimg.1999.0484
   Frith CD, 2008, NEURON, V60, P503, DOI 10.1016/j.neuron.2008.10.032
   Frith CD, 1999, SCIENCE, V286, P1692, DOI 10.1126/science.286.5445.1692
   Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100
   Harter S., 1999, CONSTRUCTION SELF DE
   Heerey EA, 2003, EMOTION, V3, P394, DOI 10.1037/1528-3542.3.4.394
   Henderson HA, 2009, J CHILD PSYCHOL PSYC, V50, P853, DOI 10.1111/j.1469-7610.2008.02059.x
   Hillier A, 2002, AUTISM, V6, P299, DOI 10.1177/1362361302006003007
   Hobson PR, 2006, MONOGR SOC RES CHILD, V71, pvii, DOI DOI 10.1111/J.1540-5834.2006.00387.X
   Jackson PL, 2006, NEUROPSYCHOLOGIA, V44, P752, DOI 10.1016/j.neuropsychologia.2005.07.015
   Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052
   Kennedy DP, 2008, SOC COGN AFFECT NEUR, V3, P177, DOI 10.1093/scan/nsn011
   Krienen FM, 2010, J NEUROSCI, V30, P13906, DOI 10.1523/JNEUROSCI.2180-10.2010
   Kwan VSY, 2008, J PERS SOC PSYCHOL, V94, P1062, DOI 10.1037/0022-3514.94.6.1062
   Lamm C, 2007, J COGNITIVE NEUROSCI, V19, P42, DOI 10.1162/jocn.2007.19.1.42
   Leary MR, 2003, HANDBOOK OF SELF AND IDENTITY, P3
   LEE A, 1994, J AUTISM DEV DISORD, V24, P155, DOI 10.1007/BF02172094
   Lee A, 1998, J CHILD PSYCHOL PSYC, V39, P1131, DOI 10.1111/1469-7610.00417
   Lind SE, 2009, J AUTISM DEV DISORD, V39, P643, DOI 10.1007/s10803-008-0670-7
   Lind SE, 2010, AUTISM, V14, P430, DOI 10.1177/1362361309358700
   Lind SE, 2009, J AUTISM DEV DISORD, V39, P1231, DOI 10.1007/s10803-009-0735-2
   Lombardo MV, 2010, BRAIN, V133, P611, DOI 10.1093/brain/awp306
   Lombardo MV, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000883
   Lombardo MV, 2011, CONSCIOUS COGN, V20, P130, DOI 10.1016/j.concog.2010.09.006
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Margulies DS, 2009, P NATL ACAD SCI USA, V106, P20069, DOI 10.1073/pnas.0905314106
   MARKUS H, 1977, J PERS SOC PSYCHOL, V35, P63, DOI 10.1037//0022-3514.35.2.63
   MARSH HW, 1990, J EDUC PSYCHOL, V82, P646, DOI 10.1037/0022-0663.82.4.646
   McConnell SR, 2002, J AUTISM DEV DISORD, V32, P351, DOI 10.1023/A:1020537805154
   Millward C, 2000, J AUTISM DEV DISORD, V30, P15, DOI 10.1023/A:1005455926727
   Mitchell JP, 2009, PHILOS T R SOC B, V364, P1309, DOI 10.1098/rstb.2008.0318
   Modinos G, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004618
   Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
   Moran JM, 2006, J COGNITIVE NEUROSCI, V18, P1586, DOI 10.1162/jocn.2006.18.9.1586
   NOLES SW, 1985, J CONSULT CLIN PSYCH, V53, P88, DOI 10.1037//0022-006X.53.1.88
   Northoff G, 2011, CONSCIOUS COGN, V20, P52, DOI 10.1016/j.concog.2010.09.011
   Northoff G, 2006, NEUROIMAGE, V31, P440, DOI 10.1016/j.neuroimage.2005.12.002
   Northoff G, 2004, TRENDS COGN SCI, V8, P102, DOI 10.1016/j.tics.2004.01.004
   Ochsner KN, 2005, NEUROIMAGE, V28, P797, DOI 10.1016/j.neuroimage.2005.06.069
   Pfeifer JH, 2012, DEV COGN NEUROS-NETH, V2, P55, DOI 10.1016/j.dcn.2011.07.012
   Pfeifer JH, 2007, J COGNITIVE NEUROSCI, V19, P1323, DOI 10.1162/jocn.2007.19.8.1323
   Pfeifer JH, 2009, CHILD DEV, V80, P1016, DOI 10.1111/j.1467-8624.2009.01314.x
   Qin PM, 2012, HUM BRAIN MAPP, V33, P154, DOI 10.1002/hbm.21201
   Raichle Marcus E, 2007, Neuroimage, V37, P1083, DOI 10.1016/j.neuroimage.2007.02.041
   Ray RD, 2009, CHILD DEV, V80, P1232, DOI 10.1111/j.1467-8624.2009.01327.x
   Robins R.W., 2008, HDB PERSONALITY THEO, P375
   Saxe R, 2010, HDB THEORY MIND, V1st
   Schmitz TW, 2004, NEUROIMAGE, V22, P941, DOI 10.1016/j.neuroimage.2004.02.018
   Schulte-Ruther M, 2011, SOC NEUROSCI-UK, V6, P1, DOI 10.1080/17470911003708032
   Sedikides C, 2008, PERSPECT PSYCHOL SCI, V3, P102, DOI 10.1111/j.1745-6916.2008.00068.x
   Sedikides C., 2007, SELF FRONTIERS SOCIA
   Sigman M, 1999, MONOGR SOC RES CHILD, V64, P1, DOI 10.1111/1540-5834.00002
   Singer T, 2004, SCIENCE, V303, P1157, DOI 10.1126/science.1093535
   Smith SM, 2002, HUM BRAIN MAPP, V17, P143, DOI 10.1002/hbm.10062
   Summerfield JJ, 2010, NEUROPSYCHOLOGIA, V48, P1501, DOI 10.1016/j.neuropsychologia.2010.01.022
   Svoboda E, 2006, NEUROPSYCHOLOGIA, V44, P2189, DOI 10.1016/j.neuropsychologia.2006.05.023
   TAYLOR SE, 1988, PSYCHOL BULL, V103, P193, DOI 10.1037/0033-2909.103.2.193
   Toichi M, 2002, AM J PSYCHIAT, V159, P1422, DOI 10.1176/appi.ajp.159.8.1422
   Tomlin D, 2006, SCIENCE, V312, P1047, DOI 10.1126/science.1125596
   Uddin L.Q., 2010, FRONT SYST NEUROSCI, V21, P21, DOI DOI 10.3389/FNSYS.2010.00021
   Uddin LQ, 2011, NEUROCASE, V17, P201, DOI 10.1080/13554794.2010.509320
   Wechsler D, 1991, WISC 3 MANUAL
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057
   Williams D, 2010, AUTISM, V14, P285, DOI 10.1177/1362361309344849
   Williams DM, 2009, J AUTISM DEV DISORD, V39, P865, DOI 10.1007/s10803-009-0695-6
   Yarkoni T, 2011, NAT METHODS, V8, P665, DOI [10.1038/nmeth.1635, 10.1038/NMETH.1635]
NR 81
TC 7
Z9 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 272
EP 285
DI 10.1007/s10803-012-1563-3
PG 14
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600003
PM 22760337
ER

PT J
AU Dratsch, T
   Schwartz, C
   Yanev, K
   Schilbach, L
   Vogeley, K
   Bente, G
AF Dratsch, Thomas
   Schwartz, Caroline
   Yanev, Kliment
   Schilbach, Leonhard
   Vogeley, Kai
   Bente, Gary
TI Getting a Grip on Social Gaze: Control over Others' Gaze Helps Gaze
   Detection in High-Functioning Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE High-functioning autism; Direct gaze; Control; Predictability
ID NORMAL SEX-DIFFERENCES; ASPERGER-SYNDROME; EYE-GAZE; SPECTRUM DISORDERS;
   SYSTEMATIZING QUOTIENT; EMPATHY QUOTIENT; AVERTED GAZE; CHILDREN;
   ADULTS; PERCEPTION
AB We investigated the influence of control over a social stimulus on the ability to detect direct gaze in high-functioning autism (HFA). In a pilot study, 19 participants with and 19 without HFA were compared on a gaze detection and a gaze setting task. Participants with HFA were less accurate in detecting direct gaze in the detection task, but did not differ in their ability to establish direct gaze in the setting task. In the main experiment, the results of the pilot study were replicated with 37 participants with and 39 without HFA, suggesting that individuals with HFA have a specific deficit in the passive perception of social cues as opposed to the active control, which seems to be intact.
C1 [Dratsch, Thomas; Schwartz, Caroline; Yanev, Kliment; Bente, Gary] Univ Cologne, Dept Psychol, D-50931 Cologne, Germany.
   [Schilbach, Leonhard; Vogeley, Kai] Univ Hosp Cologne, Dept Psychiat, D-50924 Cologne, Germany.
   [Schilbach, Leonhard] Max Planck Inst Neurol Res, D-50931 Cologne, Germany.
   [Vogeley, Kai] Res Ctr Juelich, Inst Neurosci & Med Cognit Neurosci INM3, Julich, Germany.
RP Dratsch, T (reprint author), Univ Cologne, Dept Psychol, Richard Strauss St 2, D-50931 Cologne, Germany.
EM t.dratsch@mac.com
RI Schilbach, Leonhard/G-5832-2010; Vogeley, K/E-4860-2012
OI Schilbach, Leonhard/0000-0001-5547-8309; Vogeley, K/0000-0002-5891-5831
CR Adams RB, 2005, EMOTION, V5, P3, DOI 10.1037/1528-3542.5.1.3
   Akechi H, 2010, NEUROPSYCHOLOGIA, V48, P2841, DOI 10.1016/j.neuropsychologia.2010.05.026
   Ashwin E, 2009, BIOL PSYCHIAT, V65, P17, DOI 10.1016/j.biopsych.2008.06.012
   Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
   BARONCOHEN S, 1988, J AUTISM DEV DISORD, V18, P379, DOI 10.1007/BF02212194
   Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
   Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Beck A. T., 1987, BECK DEPRESSION INVE
   Bente G, 2007, LECT NOTES COMPUT SC, V4563, P185
   Bente G, 1998, J NONVERBAL BEHAV, V22, P31, DOI 10.1023/A:1022900525673
   Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
   Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488
   Elsabbagh M, 2009, BIOL PSYCHIAT, V65, P31, DOI 10.1016/j.biopsych.2008.09.034
   Faja S, 2008, DEV NEUROPSYCHOL, V33, P1, DOI 10.1080/87565640701729573
   Farroni T, 2002, P NATL ACAD SCI USA, V99, P9602, DOI 10.1073/pnas.152159999
   FERRARA C, 1980, J AUTISM DEV DISORD, V10, P51, DOI 10.1007/BF02408432
   Flannery K. B., 1994, J BEHAVIORAL ED, V4, P157, DOI 10.1007/BF01544110
   Frith U, 2005, CONSCIOUS COGN, V14, P719, DOI 10.1016/j.concog.2005.04.006
   Gamer M, 2007, J EXP PSYCHOL HUMAN, V33, P705, DOI 10.1037/0096-1523.33.3.705
   Gepner B, 2001, J AUTISM DEV DISORD, V31, P37, DOI 10.1023/A:1005609629218
   Gepner B, 1996, CHILD NEUROPSYCHOL, V2, P123, DOI 10.1080/09297049608401357
   Golan Ofer, 2010, J Autism Dev Disord, V40, P269, DOI 10.1007/s10803-009-0862-9
   Gomot M, 2012, INT J PSYCHOPHYSIOL, V83, P240, DOI 10.1016/j.ijpsycho.2011.09.017
   Grice SJ, 2005, CORTEX, V41, P342, DOI 10.1016/S0010-9452(08)70271-5
   Hautzinger M, 1995, BECK DEPRESSIONS INV, V2
   Howard MA, 2000, NEUROREPORT, V11, P2931, DOI 10.1097/00001756-200009110-00020
   HUTT C, 1966, BEHAV SCI, V11, P346, DOI 10.1002/bs.3830110504
   Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
   Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
   Kuzmanovic B, 2009, NEUROIMAGE, V46, P1154, DOI 10.1016/j.neuroimage.2009.03.037
   Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
   Lehnhardt FG, 2011, FORTSCHR NEUROL PSYC, V79, P290, DOI 10.1055/s-0031-1273233
   Loth E, 2010, J AUTISM DEV DISORD, V40, P730, DOI 10.1007/s10803-009-0929-7
   MARTIN W, 1982, J PSYCHOL, V110, P203
   Myowa-Yamakoshi M., 2003, COGNITION, V89, P53
   Nation K, 2008, DEV PSYCHOPATHOL, V20, P79, DOI 10.1017/S0954579408000047
   Pitskel NB, 2011, J AUTISM DEV DISORD, V41, P1686, DOI 10.1007/s10803-011-1197-x
   Qian N, 2011, FRONT HUM NEUROSCI, V5, DOI 10.3389/fnhum.2011.00077
   RICHER JM, 1976, ACTA PSYCHIAT SCAND, V53, P193, DOI 10.1111/j.1600-0447.1976.tb00074.x
   Ristic J, 2005, COGNITIVE BRAIN RES, V24, P715, DOI 10.1016/j.cogbrainres.2005.02.007
   Sanefuji W, 2011, INFANT MENT HEALTH J, V32, P134, DOI 10.1002/imhj.20287
   Schilbach L, 2012, AUTISM, V16, P151, DOI 10.1177/1362361311409258
   Senju A, 2008, BRAIN COGNITION, V67, P127, DOI 10.1016/j.bandc.2007.12.001
   Senju A, 2003, COGNITION, V89, P43
   Senju A, 2005, VIS COGN, V12, P1474, DOI 10.1080/13506280444000797
   Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009
   Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
   Swettenham J., 2001, ANN M COGN NEUR SOC
   Tewes U, 1994, HAMBURG WECHSLER INT
   von Aster M., 2006, WECHSLER INTELLIGENZ
   Wallace S, 2006, PERCEPTION, V35, P1651, DOI 10.1068/p5442
   Webster S., 2011, CHILD DEV RES, DOI [10.1155/2011/462389, DOI 10.1155/2011/462389]
   Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
   Wilms M, 2010, SOC COGN AFFECT NEUR, V5, P98, DOI 10.1093/scan/nsq024
NR 57
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 286
EP 300
DI 10.1007/s10803-012-1569-x
PG 15
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600004
PM 22696196
ER

PT J
AU Ploog, BO
   Scharf, A
   Nelson, D
   Brooks, PJ
AF Ploog, Bertram O.
   Scharf, Alexa
   Nelson, DeShawn
   Brooks, Patricia J.
TI Use of Computer-Assisted Technologies (CAT) to Enhance Social,
   Communicative, and Language Development in Children with Autism Spectrum
   Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Computer-assisted technology; Autism; Efficacy; Language; Social skills;
   Emotion recognition
ID COMPLEX EMOTION RECOGNITION; HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME;
   VIRTUAL ENVIRONMENTS; STIMULUS OVERSELECTIVITY; INTERACTIVE MULTIMEDIA;
   ANIMATED TUTOR; PRETEND PLAY; INSTRUCTION; SKILLS
AB Major advances in multimedia computer technology over the past decades have made sophisticated computer games readily available to the public. This, combined with the observation that most children, including those with autism spectrum disorders (ASD), show an affinity to computers, has led researchers to recognize the potential of computer technology as an effective and efficient tool in research and treatment. This paper reviews the use of computer-assisted technology (CAT), excluding strictly internet-based approaches, to enhance social, communicative, and language development in individuals with ASD by dividing the vast literature into four main areas: language, emotion recognition, theory of mind, and social skills. Although many studies illustrate the tremendous promise of CAT to enhance skills of individuals with ASD, most lack rigorous, scientific assessment of efficacy relative to non-CAT approaches.
C1 [Ploog, Bertram O.; Nelson, DeShawn; Brooks, Patricia J.] CUNY, Grad Ctr, New York, NY 10016 USA.
   [Ploog, Bertram O.; Scharf, Alexa; Brooks, Patricia J.] CUNY Coll Staten Isl, Dept Psychol, Staten Isl, NY 10314 USA.
RP Ploog, BO (reprint author), CUNY Coll Staten Isl, Dept Psychol, 4S-105,2800 Victory Blvd, Staten Isl, NY 10314 USA.
EM bertram.ploog@csi.cuny.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Anderson CA, 2010, PSYCHOL BULL, V136, P151, DOI 10.1037/a0018251
   Baron-Cohen S, 2001, INT REV RES MENT RET, V23, P169
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Bayley N., 1969, BAYLEY SCALES INFANT
   Bernard-Opitz V., 1999, AUTISM, V3, P131, DOI 10.1177/1362361399003002004
   Bernard-Opitz V, 2001, J AUTISM DEV DISORD, V31, P377, DOI 10.1023/A:1010660502130
   Bolte S, 2010, AUTISM, V14, P155, DOI 10.1177/1362361310365028
   Bolte S, 2006, BEHAV NEUROSCI, V120, P211, DOI 10.1037/0735-7044.120.1.211
   Boone R., 1996, FOCUS AUTISM OTHER D, V11, P69
   Bosseler A, 2003, J AUTISM DEV DISORD, V33, P653, DOI 10.1023/B:JADD.0000006002.82367.4f
   Brigance AH, 2004, BRIGANCE INVENTORY E
   Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
   Charlop-Christy MH, 2003, J POSIT BEHAV INTERV, V5, P12, DOI 10.1177/10983007030050010101
   CHEN SHA, 1993, MENT RETARD, V31, P368
   Cihak DF, 2011, RES AUTISM SPECT DIS, V5, P433, DOI 10.1016/j.rasd.2010.06.006
   Clark R. E., 2005, Journal of Educational Computing Research, V32, DOI 10.2190/7LRM-3BR2-44GW-9QQY
   COLBY KM, 1973, J AUTISM CHILD SCHIZ, V3, P254, DOI 10.1007/BF01538283
   Coleman-Martin M. B., 2005, FOCUS AUTISM OTHER D, V20, P80, DOI [10.1177/10883576050200020401, DOI 10.1177/10883576050200020401]
   D'Ateno P, 2003, J POSIT BEHAV INTERV, V5, P5, DOI 10.1177/10983007030050010801
   Dauphin M, 2004, J POSIT BEHAV INTERV, V6, P238, DOI 10.1177/10983007040060040501
   Dunn L M., 1982, BRIT PICTURE VOCABUL
   Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
   Farr W, 2010, AUTISM, V14, P237, DOI 10.1177/1362361310363280
   Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
   Golan O, 2006, SOC NEUROSCI-UK, V1, P111, DOI 10.1080/17470910600980986
   Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
   Golan O, 2010, J AUTISM DEV DISORD, V40, P269, DOI 10.1007/s10803-009-0862-9
   Golan O, 2006, J AUTISM DEV DISORD, V36, P169, DOI 10.1007/s10803-005-0057-y
   Goodwin MS, 2008, FOCUS AUTISM DEV DIS, V23, P125, DOI 10.1177/1088357608316678
   Gross TF, 2005, J AUTISM DEV DISORD, V35, P773, DOI 10.1007/s10803-005-0023-8
   Grynszpan O, 2008, INT J HUM-COMPUT ST, V66, P628, DOI 10.1016/j.ijhcs.2008.04.001
   Grynszpan O, 2007, INTERACT STUD, V8, P241, DOI 10.1075/is.8.2.04gry
   Hailpern J., 2008, SPOKEN IMPACT PROJEC
   Heimann M., 1993, SCANDINAVIAN J LOGOP, V18, P3
   HEIMANN M, 1995, J AUTISM DEV DISORD, V25, P459, DOI 10.1007/BF02178294
   Hetzroni O. E., 2005, FOCUS AUTISM OTHER D, V20, P201, DOI DOI 10.1177/10883576050200040201
   Hetzroni OE, 2004, J AUTISM DEV DISORD, V34, P95, DOI 10.1023/B:JADD.0000022602.40506.bf
   Kagohara D. M., 2011, J BEHAV ED, V20, P33, DOI 10.1007/s10864-010-9115-4
   Kaufman A. S., 1990, KAUFMAN BRIEF INTELL
   Kimball J., 2004, ED TREATMENT CHILDRE, V27, P280
   Kimball J. W., 2007, FOCUS AUTISM OTHER D, V22, P131, DOI 10.1177/10883576070220020501
   Kodak T, 2011, RES AUTISM SPECT DIS, V5, P640, DOI 10.1016/j.rasd.2010.07.011
   Krantz PJ, 1998, J APPL BEHAV ANAL, V31, P191, DOI 10.1901/jaba.1998.31-191
   Krug D. A., 1980, AUTISM SCREENING INS
   KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
   Lacava PG, 2007, REM SPEC EDUC, V28, P174, DOI 10.1177/07419325070280030601
   Lacava PG, 2010, AUTISM, V14, P161, DOI 10.1177/1362361310362085
   Leiter R. G., 1980, LEITER INT PERFORMAN
   Lindner JL, 2006, J AUTISM DEV DISORD, V36, P769, DOI 10.1007/s10803-006-0105-2
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lord C, 2002, J AM ACAD CHILD PSY, V41, P1134, DOI 10.1097/00004583-200209000-00015
   MacDonald R, 2005, BEHAV INTERVENT, V20, P225, DOI 10.1002/bin.197
   MacDonald R, 2009, J APPL BEHAV ANAL, V42, P43, DOI 10.1901/jaba.2009.42-43
   Massaro D. W., 2006, ADV SPOKEN LANGUAGE, P212
   Massaro DW, 2006, AUTISM, V10, P495, DOI 10.1177/1362361306066599
   Mineo BA, 2009, J AUTISM DEV DISORD, V39, P172, DOI 10.1007/s10803-008-0616-0
   Moore D., 2005, FOCUS AUTISM OTHER D, V20, P231, DOI DOI 10.1177/10883576050200040501
   Moore M, 2000, J AUTISM DEV DISORD, V30, P359, DOI 10.1023/A:1005535602064
   Nelson K.E., 1998, AUTISM, V2, P139, DOI 10.1177/1362361398022003
   Nikopoulos CK, 2007, J AUTISM DEV DISORD, V37, P678, DOI 10.1007/s10803-006-0195-x
   Njiokiktjien C, 2001, EUR CHILD ADOLES PSY, V10, P79
   Parsons S, 2006, COMPUT EDUC, V47, P186, DOI 10.1016/j.compedu.2004.10.003
   Parsons S, 2004, J AUTISM DEV DISORD, V34, P449, DOI 10.1023/B:JADD.0000037421.98517.8d
   Pennington RC, 2010, FOCUS AUTISM DEV DIS, V25, P239, DOI 10.1177/1088357610378291
   PLIENIS AJ, 1985, ANAL INTERVEN DEVEL, V5, P345, DOI 10.1016/0270-4684(85)90004-7
   Ploog BO, 2010, EDUC COMPET GLOB WOR, P281
   Ploog BO, 2009, RES AUTISM SPECT DIS, V3, P743, DOI 10.1016/j.rasd.2009.02.004
   Ploog BO, 2007, J AUTISM DEV DISORD, V37, P1514, DOI 10.1007/s10803-006-0244-5
   PLOOG BO, 1995, LEARN MOTIV, V26, P161, DOI 10.1016/0023-9690(95)90003-9
   Ploog BO, 2010, J AUTISM DEV DISORD, V40, P1332, DOI 10.1007/s10803-010-0990-2
   Powers K. L., 2011, BIENN M SOC RES CHIL
   Prinz P. M., 1991, ALPHA INTERACTIVE LA
   Rajendran G, 2006, J SPEECH LANG HEAR R, V49, P102, DOI 10.1044/1092-4388(2006/008)
   Ramdoss S., 2011, J BEHAV ED, V20, P55, DOI 10.1007/s10864-010-9112-7
   Raven J. C., 1984, COLOURED PROGR MATRI
   Rutten A, 2003, J VISUAL COMP ANIMAT, V14, P233, DOI 10.1002/vis.320
   Sansosti FJ, 2008, J POSIT BEHAV INTERV, V10, P162, DOI 10.1177/1098300708316259
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Schreibman L., 1989, CHRONIC SCHIZOPHRENI, P181
   Sigafoos J., 2011, J BEHAV ED, V20, P1, DOI 10.1007/s10864-011-9120-2
   Silver M, 2001, AUTISM, V5, P299, DOI 10.1177/1362361301005003007
   Simpson A, 2004, EDUC TRAIN DEV DISAB, V39, P240
   Sparrow S., 1985, VINELAND ADAPTIVE BE
   Strickland D, 1996, PRESENCE-TELEOP VIRT, V5, P319
   Strickland DC, 2007, TOP LANG DISORD, V27, P226
   Stromer R., 2006, FOCUS AUTISM OTHER D, V21, P14, DOI 10.1177/10883576060210010301
   Swettenham J, 1996, J CHILD PSYCHOL PSYC, V37, P157, DOI 10.1111/j.1469-7610.1996.tb01387.x
   Tager-Flusberg H, 2003, PHILOS T ROY SOC B, V358, P303, DOI 10.1098/rstb.2002.1198
   Tjus T, 2001, AUTISM, V5, P175, DOI 10.1177/1362361301005002007
   Trepagnier C., 2005, ANN REV CYBERTHERAPY, V3, P101, DOI [10.1109/TVCG.2013.42, DOI 10.1109/TVCG.2013.42]
   Wainer AL, 2011, RES AUTISM SPECT DIS, V5, P96, DOI 10.1016/j.rasd.2010.08.002
   Wallace S, 2010, AUTISM, V14, P199, DOI 10.1177/1362361310363283
   Whalen C, 2010, AUTISM, V14, P179, DOI 10.1177/1362361310363282
   Whalen C., 2006, J SPEECH LANGUAGE PA, V1, P11
   WHO, 1993, ICD 10 CLASS MENT BE
   Williams C, 2002, AUTISM, V6, P71, DOI 10.1177/1362361302006001006
   Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008
   Williams K. T., 1997, EXPRESSIVE VOCABULAR
   WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
   Yamamoto J, 1999, RES DEV DISABIL, V20, P355, DOI 10.1016/S0891-4222(99)00017-7
   Yaw J., 2011, J BEHAV ED, V20, P44, DOI [10.1007/s10864-010-9118-1, DOI 10.1007/S10864-010-9118-1]
NR 103
TC 14
Z9 14
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 301
EP 322
DI 10.1007/s10803-012-1571-3
PG 22
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600005
PM 22706582
ER

PT J
AU Gowen, E
   Hamilton, A
AF Gowen, Emma
   Hamilton, Antonia
TI Motor Abilities in Autism: A Review Using a Computational Context
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Motor control; Sensorimotor integration; Prediction; Motor
   learning
ID HIGH-FUNCTIONING AUTISM; DEVELOPMENTAL COORDINATION DISORDER; SACCADIC
   EYE-MOVEMENTS; SIGNAL-DEPENDENT NOISE; DORSAL VISUAL PATHWAY; SPECTRUM
   DISORDERS; ASPERGER-SYNDROME; INTERNAL-MODELS; YOUNG-CHILDREN; SENSORY
   ABNORMALITIES
AB Altered motor behaviour is commonly reported in Autism Spectrum Disorder, but the aetiology remains unclear. Here, we have taken a computational approach in order to break down motor control into different components and review the functioning of each process. Our findings suggest abnormalities in two areas-poor integration of information for efficient motor planning, and increased variability in basic sensory inputs and motor outputs. In contrast, motor learning processes are relatively intact and there is inconsistent evidence for deficits in predictive control. We suggest future work on motor abilities in autism should focus on sensorimotor noise and on higher level motor planning, as these seem to have a significant role in causing motor difficulties for autistic individuals.
C1 [Gowen, Emma] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England.
   [Hamilton, Antonia] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
RP Gowen, E (reprint author), Univ Manchester, Fac Life Sci, Carys Bannister Bldg,Dover St, Manchester M13 9PT, Lancs, England.
EM emma.gowen@manchester.ac.uk
RI Hamilton, Antonia/B-3612-2008
OI Hamilton, Antonia/0000-0001-8000-0219
CR Alais D, 2004, CURR BIOL, V14, P257, DOI 10.1016/j.cub.2004.01.029
   Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
   Barnes KA, 2008, NEUROPSYCHOLOGY, V22, P563, DOI 10.1037/0894-4105.22.5.563
   Bastian AJ, 2006, CURR OPIN NEUROBIOL, V16, P645, DOI 10.1016/j.conb.2006.08.016
   Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
   BEPPU H, 1984, BRAIN, V107, P787, DOI 10.1093/brain/107.3.787
   Berstein N. A., 1967, COORDINATION REGULAT
   Bertone A, 2003, J COGNITIVE NEUROSCI, V15, P218, DOI 10.1162/089892903321208150
   Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561
   Binda P, 2007, J NEUROSCI, V27, P8525, DOI 10.1523/JNEUROSCI.0737-07.2007
   Blaesi S, 2010, BRAIN COGNITION, V72, P306, DOI 10.1016/j.bandc.2009.10.001
   Blakemore SJ, 2000, NEUROREPORT, V11, pR11, DOI 10.1097/00001756-200008030-00002
   Blakemore SJ, 2001, NEUROREPORT, V12, P1879, DOI 10.1097/00001756-200107030-00023
   Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013
   Botvinick MM, 2008, TRENDS COGN SCI, V12, P201, DOI 10.1016/j.tics.2008.02.009
   BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
   Brian J, 2008, AUTISM, V12, P433, DOI 10.1177/1362361308094500
   Brown J, 2010, Q J EXP PSYCHOL, V63, P1789, DOI 10.1080/17470210903536910
   Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072
   Cascio C, 2008, J AUTISM DEV DISORD, V38, P127, DOI 10.1007/s10803-007-0370-8
   Cascio C. J., 2012, AUTISM IN PRESS
   Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
   Clearfield MW, 2011, INFANT BEHAV DEV, V34, P15, DOI 10.1016/j.infbeh.2010.04.008
   Cohen RG, 2004, EXP BRAIN RES, V157, P486, DOI 10.1007/s00221-004-1862-9
   Cook J, 2009, NEUROPSYCHOLOGIA, V47, P3275, DOI 10.1016/j.neuropsychologia.2009.07.010
   Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
   Crane L, 2009, AUTISM, V13, P215, DOI 10.1177/1362361309103794
   Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
   d'Avella A, 2005, P NATL ACAD SCI USA, V102, P3076, DOI 10.1073/pnas.0500199102
   David FJ, 2009, PEDIATR PHYS THER, V21, P205, DOI 10.1097/PEP.0b013e3181a3afc2
   D'Cruz AM, 2009, BIOL PSYCHIAT, V66, P393, DOI 10.1016/j.biopsych.2009.01.008
   de Jonge MV, 2007, NEUROPSYCHOLOGY, V21, P65, DOI 10.1037/0894-4105.21.1.65
   DENCKLA MB, 1985, PSYCHOPHARMACOL BULL, V21, P773
   Dewey D, 2007, J INT NEUROPSYCH SOC, V13, P246, DOI 10.1017/S1355617707070270
   Diedrichsen J, 2010, TRENDS COGN SCI, V14, P31, DOI 10.1016/j.tics.2009.11.004
   Dowell LR, 2009, NEUROPSYCHOLOGY, V23, P563, DOI 10.1037/a0015640
   Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
   Elliott D, 2010, PSYCHOL BULL, V136, P1023, DOI 10.1037/a0020958
   Ernst MO, 2002, NATURE, V415, P429, DOI 10.1038/415429a
   Eskenazi T, 2009, PSYCHOL RES-PSYCH FO, V73, P477, DOI 10.1007/s00426-009-0231-5
   Esposito G, 2009, BRAIN DEV-JPN, V31, P131, DOI 10.1016/j.braindev.2008.04.005
   Fabbri-Destro M, 2009, EXP BRAIN RES, V192, P521, DOI 10.1007/s00221-008-1578-3
   FITTS PM, 1954, J EXP PSYCHOL, V47, P381, DOI 10.1037/h0055392
   Flanagan JR, 1997, J NEUROSCI, V17, P1519
   Foss-Feig JH, 2010, EXP BRAIN RES, V203, P381, DOI 10.1007/s00221-010-2240-4
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025
   Freitag CM, 2007, J AUTISM DEV DISORD, V37, P948, DOI 10.1007/s10803-006-0235-6
   Fuentes CT, 2011, J AUTISM DEV DISORD, V41, P1352, DOI 10.1007/s10803-010-1161-1
   Gallese V, 2009, DEV PSYCHOL, V45, P103, DOI 10.1037/a0014436
   GEPNER B, 1995, NEUROREPORT, V6, P1211, DOI 10.1097/00001756-199505300-00034
   Gernsbacher MA, 2008, J CHILD PSYCHOL PSYC, V49, P43, DOI 10.1111/j.1469-7610.2007.01820.x
   GHAZIUDDIN M, 1994, J INTELL DISABIL RES, V38, P519
   Glazebrook CM, 2008, J AUTISM DEV DISORD, V38, P114, DOI 10.1007/s10803-007-0369-1
   Glazebrook CM, 2006, MOTOR CONTROL, V10, P244
   Glazebrook CM, 2009, AUTISM, V13, P411, DOI 10.1177/1362361309105659
   Gobet F, 2001, TRENDS COGN SCI, V5, P236, DOI 10.1016/S1364-6613(00)01662-4
   Goldberg MC, 2002, NEUROPSYCHOLOGIA, V40, P2039, DOI 10.1016/S0028-3932(02)00059-3
   Gowen E, 2005, CEREBELLUM, V4, P279, DOI 10.1080/14734220500355332
   Grafton ST, 2007, HUM MOVEMENT SCI, V26, P590, DOI 10.1016/j.humov.2007.05.009
   Graybiel AM, 1998, NEUROBIOL LEARN MEM, V70, P119, DOI 10.1006/nlme.1998.3843
   Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054
   HAGGARD P, 1995, J NEUROL NEUROSUR PS, V58, P433, DOI 10.1136/jnnp.58.4.433
   Hamilton AFD, 2009, J CHILD PSYCHOL PSYC, V50, P881, DOI 10.1111/j.1469-7610.2009.02098.x
   Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Harris CM, 1998, NATURE, V394, P780, DOI 10.1038/29528
   Harrison J, 2004, J AUTISM DEV DISORD, V34, P727, DOI 10.1007/s10803-004-5293-z
   Haruno M, 2001, NEURAL COMPUT, V13, P2201, DOI 10.1162/089976601750541778
   Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356
   Henderson SE, 1992, MOVEMENT ASSESSMENT
   HERMSDORFER J, 1994, MOVEMENT DISORD, V9, P650, DOI 10.1002/mds.870090611
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   HORE J, 1991, J NEUROPHYSIOL, V65, P563
   Hore J, 1996, J NEUROPHYSIOL, V76, P3693
   Hughes C, 1996, J AUTISM DEV DISORD, V26, P99, DOI 10.1007/BF02276237
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Jasmin E, 2009, J AUTISM DEV DISORD, V39, P231, DOI 10.1007/s10803-008-0617-z
   Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
   Jones KE, 2002, J NEUROPHYSIOL, V88, P1533, DOI 10.1152/jn.00985.2001
   Jordan MI, 1999, COGNITIVE NEUROSCIEN
   Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x
   Kaiser MD, 2009, PSYCHON B REV, V16, P761, DOI 10.3758/PBR.16.5.761
   Kawato Mitsuo, 2003, Prog Brain Res, V142, P171
   Kelso J. A. S., 1995, DYNAMIC PATTERNS SEL
   Kemner C, 1998, J AUTISM DEV DISORD, V28, P61, DOI 10.1023/A:1026015120128
   Kern JK, 2006, AUTISM, V10, P480, DOI 10.1177/1362361306066564
   Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
   KOHENRAZ R, 1992, J AUTISM DEV DISORD, V22, P419, DOI 10.1007/BF01048244
   Koldewyn K, 2010, BRAIN, V133, P599, DOI 10.1093/brain/awp272
   Kwakye Leslie D, 2011, Front Integr Neurosci, V4, P129, DOI 10.3389/fnint.2010.00129
   LANDY MS, 1995, VISION RES, V35, P389, DOI 10.1016/0042-6989(94)00176-M
   Largo R. H., 2002, ZURCHER NEUROMOTORIK
   Larson JCG, 2008, BRAIN, V131, P2894, DOI 10.1093/brain/awn226
   Leary MR, 1996, MENT RETARD, V34, P39
   Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   MacNeil LK, 2012, NEUROPSYCHOLOGY, V26, P165, DOI 10.1037/a0026955
   MANJIVIONA J, 1995, J AUTISM DEV DISORD, V25, P23, DOI 10.1007/BF02178165
   Mari M, 2003, PHILOS T ROY SOC B, V358, P393, DOI 10.1098/rstb.2002.1205
   Martin JS, 2010, J AUTISM DEV DISORD, V40, P640, DOI 10.1007/s10803-009-0904-3
   Miall RC, 1996, NEURAL NETWORKS, V9, P1265, DOI 10.1016/S0893-6080(96)00035-4
   Milne E, 2002, J CHILD PSYCHOL PSYC, V43, P255, DOI 10.1111/1469-7610.00018
   Milne E, 2006, J AUTISM DEV DISORD, V36, P225, DOI 10.1007/s10803-005-0052-3
   Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002
   Minshew NJ, 2004, NEUROLOGY, V63, P2056
   Miyahara M, 1997, J AUTISM DEV DISORD, V27, P595, DOI 10.1023/A:1025834211548
   Molloy CA, 2003, J AUTISM DEV DISORD, V33, P643, DOI 10.1023/B:JADD.0000006001.00667.4c
   Mosconi MW, 2009, PSYCHOL MED, V39, P1559, DOI 10.1017/S0033291708004984
   Mostofsky SH, 2006, J INT NEUROPSYCH SOC, V12, P314, DOI 10.1017/S1355617706060437
   Mostofsky SH, 2004, NEUROCASE, V10, P60, DOI 10.1080/13554790490960503
   Mostofsky SH, 2000, J INT NEUROPSYCH SOC, V6, P752, DOI 10.1017/S1355617700677020
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   MULLER F, 1994, EXP BRAIN RES, V101, P485
   Nazarali N, 2009, J AUTISM DEV DISORD, V39, P1401, DOI 10.1007/s10803-009-0756-x
   Nemeth D, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011731
   NISSEN MJ, 1987, COGNITIVE PSYCHOL, V19, P1, DOI 10.1016/0010-0285(87)90002-8
   O'Riordan M, 2006, J AUTISM DEV DISORD, V36, P665, DOI 10.1007/s10803-006-0106-1
   O'Riordan M, 2001, Q J EXP PSYCHOL-A, V54, P961, DOI 10.1080/02724980042000543
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   Osborne LC, 2005, NATURE, V437, P412, DOI 10.1038/nature03961
   Ozonoff S, 2008, J AUTISM DEV DISORD, V38, P644, DOI 10.1007/s10803-007-0430-0
   Pan CY, 2009, J AUTISM DEV DISORD, V39, P1694, DOI 10.1007/s10803-009-0813-5
   Pascolo PB, 2012, J ELECTROMYOGR KINES, V22, P98, DOI 10.1016/j.jelekin.2011.07.009
   Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003
   Pellicano E, 2008, NEUROPSYCHOLOGIA, V46, P2593, DOI 10.1016/j.neuropsychologia.2008.04.008
   Provost B, 2007, J AUTISM DEV DISORD, V37, P321, DOI 10.1007/s10803-006-0170-6
   Rinehart NJ, 2001, J AUTISM DEV DISORD, V31, P79, DOI 10.1023/A:1005617831035
   Rinehart NJ, 2006, J AUTISM DEV DISORD, V36, P757, DOI 10.1007/s10803-006-0118-x
   Rinehart NJ, 2006, EUR CHILD ADOLES PSY, V15, P256, DOI 10.1007/s00787-006-0530-y
   ROSENBAUM DA, 1980, J EXP PSYCHOL GEN, V109, P444, DOI 10.1037/0096-3445.109.4.444
   ROSENBAUM DA, 1990, ATTENTION PERFORM, V8, P321
   Rosenbaum DA, 2006, PSYCHON B REV, V13, P918, DOI 10.3758/BF03194019
   Sanger TD, 2003, CURR OPIN NEUROBIOL, V13, P238, DOI 10.1016/S0959-4388(03)00034-5
   Schmitz C, 2003, NEUROSCI LETT, V348, P17, DOI 10.1016/S0304-3940(03)00644-X
   Shadmehr R, 2008, EXP BRAIN RES, V185, P359, DOI 10.1007/s00221-008-1280-5
   Shadmehr R, 2010, ANNU REV NEUROSCI, V33, P89, DOI 10.1146/annurev-neuro-060909-153135
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Shams L, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00264
   Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
   Spence C, 2004, J PHYSIOL-PARIS, V98, P171, DOI 10.1016/j.jphysparis.2004.03.008
   Stanley-Cary C, 2011, CEREBELLUM, V10, P70, DOI 10.1007/s12311-010-0229-y
   Staples KL, 2010, J AUTISM DEV DISORD, V40, P209, DOI 10.1007/s10803-009-0854-9
   Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
   Szelag E, 2004, BRIT J PSYCHOL, V95, P269, DOI 10.1348/0007126041528167
   Takarae Y, 2004, J NEUROL NEUROSUR PS, V75, P1359, DOI 10.1136/jnnp.2003.022491
   Taylor N, 2010, J AUTISM DEV DISORD, V40, P1403, DOI 10.1007/s10803-010-1000-4
   Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
   Tommerdahl M, 2007, BRAIN RES, V1154, P116, DOI 10.1016/j.brainres.2007.04.032
   Tsermentseli S, 2008, J AUTISM DEV DISORD, V38, P1201, DOI 10.1007/s10803-007-0500-3
   Ulrich D. A., 2000, TEST GROSS MOTOR DEV
   van Beers RJ, 2007, J NEUROSCI, V27, P8757, DOI 10.1523/JNEUROSCI.2311-07.2007
   van der Smagt MJ, 2007, J AUTISM DEV DISORD, V37, P2014, DOI 10.1007/s10803-006-0346-0
   van Swieten LM, 2010, J EXP PSYCHOL HUMAN, V36, P493, DOI 10.1037/a0017177
   Van Waelvelde H, 2010, DEV MED CHILD NEUROL, V52, pe174, DOI 10.1111/j.1469-8749.2009.03606.x
   Vernazza-Martin S, 2005, J AUTISM DEV DISORD, V35, P91, DOI 10.1007/s10803-004-1037-3
   Williams J, 2008, HUM MOVEMENT SCI, V27, P270, DOI 10.1016/j.humov.2008.02.008
   Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
   Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008
   Wilson M, 2005, PSYCHOL BULL, V131, P460, DOI 10.1037/0033-2909.131.3.460
   WING AM, 1973, PERCEPT PSYCHOPHYS, V14, P5, DOI 10.3758/BF03198607
   Wolpert DM, 1997, TRENDS COGN SCI, V1, P209, DOI 10.1016/S1364-6613(97)01070-X
   Wolpert DM, 2003, PHILOS T R SOC B, V358, P593, DOI 10.1098/rstb.2002.1238
   Wolpert DM, 2000, NAT NEUROSCI, V3, P1212, DOI 10.1038/81497
   Wolpert DM, 2001, CURR BIOL, V11, pR729, DOI 10.1016/S0960-9822(01)00432-8
   Wozny David R, 2011, Front Integr Neurosci, V5, P75, DOI 10.3389/fnint.2011.00075
   YOUNG RP, 1992, ACTA PSYCHOL, V79, P59, DOI 10.1016/0001-6918(91)90073-9
NR 167
TC 18
Z9 18
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 323
EP 344
DI 10.1007/s10803-012-1574-0
PG 22
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600006
PM 22723127
ER

PT J
AU Coman, D
   Alessandri, M
   Gutierrez, A
   Novotny, S
   Boyd, B
   Hume, K
   Sperry, L
   Odom, S
AF Coman, Drew
   Alessandri, Michael
   Gutierrez, Anibal
   Novotny, Stephanie
   Boyd, Brian
   Hume, Kara
   Sperry, Laurie
   Odom, Samuel
TI Commitment to Classroom Model Philosophy and Burnout Symptoms Among High
   Fidelity Teachers Implementing Preschool Programs for Children with
   Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Teacher commitment; Burnout; Autism spectrum disorders; Comprehensive
   treatment models
ID GENERAL-EDUCATION TEACHERS; DIDST THOU GO; NATIONAL PERSPECTIVE; JOB
   BURNOUT; ATTRITION; RETENTION; PREDICTORS; INVENTORY; VALIDITY
AB Teacher commitment to classroom model philosophy and burnout were explored in a sample of 53 teachers implementing three preschool models at high levels of fidelity for students with autism: Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH); Learning Experiences and Alternative Program for Preschoolers and Their Parents (LEAP); and high quality special education programs (HQSEP's). Relative to the other groups, LEAP teachers reported significantly higher levels of commitment to LEAP philosophy while TEACCH teachers did not report significantly higher commitment levels to TEACCH philosophy. Teachers in HQSEP's reported similar levels of commitment to TEACCH and LEAP. Burnout was also low to moderate in this sample relative to normative data. Implications for school districts and teachers are discussed.
C1 [Coman, Drew; Alessandri, Michael; Novotny, Stephanie] Univ Miami, Dept Psychol, Coral Gables, FL 33146 USA.
   [Gutierrez, Anibal] Florida Int Univ, Dept Psychol, Miami, FL 33199 USA.
   [Boyd, Brian] Univ N Carolina, Dept Allied Hlth Sci, Chapel Hill, NC USA.
   [Hume, Kara; Odom, Samuel] Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC USA.
   [Sperry, Laurie] Univ Colorado, Sch Educ & Human Dev, Denver, CO 80202 USA.
RP Coman, D (reprint author), Univ Miami, Dept Psychol, 5665 Ponce de Leon Blvd, Coral Gables, FL 33146 USA.
EM dcoman@psy.miami.edu
CR Bandura A, 1963, SOCIAL LEARNING PERS
   Banks S. R., 1990, TEACHER ED SPECIAL E, V13, P187
   BILLINGSLEY BS, 1992, J SPEC EDUC, V25, P453
   Billingsley BS, 2004, J SPEC EDUC, V38, P39, DOI 10.1177/00224669040380010401
   Boe EE, 1997, J SPEC EDUC, V30, P371
   Boe EE, 1997, J SPEC EDUC, V30, P390
   Chernis C., 1980, STAFF BURNOUT JOB ST
   Chernis C., 1995, BURNOUT HELPING TEAC
   Cherniss C., 1985, SPECIAL SERVICES SCH, V2, P45, DOI 10.1300/J008v02n01_04
   CORDES CL, 1993, ACAD MANAGE REV, V18, P621, DOI 10.2307/258593
   Council for Exceptional Children, 2000, BRIGHT FUT EXC LEARN
   Dymond S. K., 2007, J DISABIL POLICY STU, V18, P133, DOI 10.1177/10442073070180030201
   Farber B. A., 1991, CRISIS ED STRESS BUR
   Farber B. A., 1983, STRESS BURNOUT HUMAN, P198
   Firth G. H., 1985, TEACHING EXCEPTIONAL, V17, P225
   Fore C., 2002, HIGH SCH J, P36
   GOLD Y, 1984, EDUC PSYCHOL MEAS, V44, P1009, DOI 10.1177/0013164484444024
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Hume K, 2011, RES AUTISM SPECT DIS, V5, P1430, DOI 10.1016/j.rasd.2011.02.002
   IWANICKI EF, 1981, EDUC PSYCHOL MEAS, V41, P1167
   JACKSON SE, 1986, J APPL PSYCHOL, V71, P630, DOI 10.1037/0021-9010.71.4.630
   Jennett HK, 2003, J AUTISM DEV DISORD, V33, P583, DOI 10.1023/B:JADD.0000005996.19417.57
   Lord C, 2005, J AUTISM DEV DISORD, V35, P695, DOI 10.1007/s10803-005-0017-6
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Maslach C, 2001, ANNU REV PSYCHOL, V52, P397, DOI 10.1146/annurev.psych.52.1.397
   MASLACH C, 1981, J OCCUP BEHAV, V2, P99, DOI 10.1002/job.4030020205
   Maslach C., 1996, MASLACH BURNOUT INVE, V3rd
   Mesibov GB, 2010, J AUTISM DEV DISORD, V40, P570, DOI 10.1007/s10803-009-0901-6
   Miller M. D., 1999, EXCEPT CHILDREN, V65, P201
   Mischel W., 1971, INTRO PERSONALITY
   Morsink C. V., 1982, EXCEPTIONAL ED Q, V2, P15
   Morvant M., 1995, ATTRITION RETENTION, V1
   Nichols A. S., 2002, TEACHER ED SPECIAL E, V25, P71
   Ozonoff S., 1995, LEARNING COGNITION A, P199
   Paperwork in Special Education, 2002, SPENSE FACTSHEET
   Stahmer A. C., 2005, FOCUS AUTISM OTHER D, V20, P66, DOI DOI 10.1177/1088357
   Strain P. S., 1996, PSYCHOSOCIAL TREATME, P573, DOI 10.1037/10196-022
   Wisniewski L, 1997, J SPEC EDUC, V31, P325
   ZABEL RH, 1982, EXCEPT CHILDREN, V49, P261
NR 39
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 345
EP 360
DI 10.1007/s10803-012-1573-1
PG 16
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600007
PM 22706583
ER

PT J
AU van Steensel, FJA
   Bogels, SM
   Wood, JJ
AF van Steensel, Francisca J. A.
   Bogels, Susan M.
   Wood, Jeffrey J.
TI Autism Spectrum Traits in Children with Anxiety Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Anxiety; ASD; ADI-R; Children; Risk factor
ID PERVASIVE DEVELOPMENTAL DISORDERS; OBSESSIVE-COMPULSIVE DISORDER;
   INTERNALIZING TRAITS; DIAGNOSTIC INTERVIEW; SOCIAL-BEHAVIOR; DSM-IV;
   ASSOCIATION; CHILDHOOD; YOUTH; QUESTIONNAIRE
AB The aim of this study was to examine ASD traits in children with clinical anxiety in early development, as well as current manifestations. Parents of 42 children with an anxiety disorder (but no known diagnosis of ASD) and 42 typically developing children were interviewed using the Autism Diagnostic Interview (ADI-R). They also completed questionnaires that assessed child anxiety (SCARED-71) and children's ASD symptoms. Results revealed that children with anxiety disorders had higher scores than typically developing children, for both ASD traits in early development as well as current ASD symptoms. A specific association was found between symptoms of Social Anxiety Disorder and ASD traits early in life. Findings are considered in terms of clinical implications, and limitations are discussed.
C1 [van Steensel, Francisca J. A.; Bogels, Susan M.] Univ Amsterdam, Res Inst Child Dev & Educ, NL-1018 VZ Amsterdam, Netherlands.
   [Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Educ, Los Angeles, CA 90095 USA.
   [Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
RP van Steensel, FJA (reprint author), Univ Amsterdam, Res Inst Child Dev & Educ, Nieuwe Prinsengracht 130, NL-1018 VZ Amsterdam, Netherlands.
EM f.j.a.vansteensel@uva.nl
CR In-Albon T, 2007, PSYCHOTHER PSYCHOSOM, V76, P15, DOI 10.1159/000096361
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bejerot S, 2009, PSYCHOPATHOLOGY, V42, P170, DOI 10.1159/000207459
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Bishop DVM, 1998, J CHILD PSYCHOL PSYC, V39, P879, DOI 10.1017/S0021963098002832
   Bodden Denise H M, 2008, Clin Child Psychol Psychiatry, V13, P543, DOI 10.1177/1359104508090602
   Bodden DHM, 2009, BEHAV RES THER, V47, P418, DOI 10.1016/j.brat.2009.01.015
   Bogels SM, 2004, PERS INDIV DIFFER, V37, P1583, DOI 10.1016/j.paid.2004.02.014
   Bogels SM, 2010, DEPRESS ANXIETY, V27, P168, DOI 10.1002/da.20670
   Brambilla P, 2003, BRAIN RES BULL, V61, P557, DOI 10.1016/j.brainresbull.2003.06.001
   Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
   Costello EJ, 2005, CHILD ADOL PSYCH CL, V14, P631, DOI 10.1016/j.chc.2005.06.003
   Field A., 2009, DISCOVERING STAT USI
   Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x
   Gregory AM, 2007, CLIN CHILD FAM PSYCH, V10, P199, DOI 10.1007/s10567-007-0022-8
   Hallett V, 2009, J AM ACAD CHILD PSY, V48, P618, DOI 10.1097/CHI.0b013e31819f7116
   Hallett V, 2010, AM J PSYCHIAT, V167, P809, DOI 10.1176/appi.ajp.2009.09070990
   Hartley SL, 2009, AUTISM, V13, P485, DOI 10.1177/1362361309335717
   Hartman CA, 2006, J AUTISM DEV DISORD, V36, P325, DOI 10.1007/s10803-005-0072-z
   Hirshfeld-Becker DR, 2007, J DEV BEHAV PEDIATR, V28, P225, DOI 10.1097/01.DBP.0000268559.34463.d0
   Hughes JR, 2009, EPILEPSY BEHAV, V16, P569, DOI 10.1016/j.yebeh.2009.09.023
   Ivarsson T, 2008, J ANXIETY DISORD, V22, P969, DOI 10.1016/j.janxdis.2007.10.003
   Juranek J, 2006, J CHILD NEUROL, V21, P1051, DOI 10.2310/7010.2006.00237
   Kendall PC, 2010, J ANXIETY DISORD, V24, P360, DOI 10.1016/j.janxdis.2010.01.009
   Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Luteijn E., 2002, VRAGENLIJST INVENTAR
   Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
   Pine DS, 2008, J AM ACAD CHILD PSY, V47, P652, DOI 10.1097/CHI.0b013e31816bffa5
   Puleo CM, 2011, J AUTISM DEV DISORD, V41, P275, DOI 10.1007/s10803-010-1047-2
   Rapee RM, 2004, CLIN PSYCHOL REV, V24, P737, DOI 10.1016/j.cpr.2004.06.004
   Silverman W. K., 1996, ANXIETY DISORDERS IN
   Silverman WK, 2001, J AM ACAD CHILD PSY, V40, P937, DOI 10.1097/00004583-200108000-00016
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Steensel F. J. A., 2011, CLIN CHILD FAM PSYCH, V14, P302
   Tabachnick B., 2001, USING MULTIVARIATE S
   Thomas KM, 2001, ARCH GEN PSYCHIAT, V58, P1057, DOI 10.1001/archpsyc.58.11.1057
   Towbin KE, 2005, J CHILD ADOL PSYCHOP, V15, P452, DOI 10.1089/cap.2005.15.452
   Werner E, 2005, ARCH GEN PSYCHIAT, V62, P889, DOI 10.1001/archpsyc.62.8.889
   Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x
   Wood JW, 2002, TLS-TIMES LIT SUPPL, P31
NR 41
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 361
EP 370
DI 10.1007/s10803-012-1575-z
PG 10
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600008
PM 22733297
ER

PT J
AU Hus, V
   Lord, C
AF Hus, Vanessa
   Lord, Catherine
TI Effects of Child Characteristics on the Autism Diagnostic
   Interview-Revised: Implications for Use of Scores as a Measure of ASD
   Severity
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Autism diagnostic interview-revised;
   Severity; Language level; Chronological age
ID SPECTRUM DISORDERS; REPETITIVE BEHAVIORS; IQ; PSYCHOPATHOLOGY;
   IDENTIFICATION; ADOLESCENTS; SYMPTOMS
AB The Autism Diagnostic Interview-Revised (ADI-R) is commonly used to inform diagnoses of autism spectrum disorders (ASD). Considering the time dedicated to using the ADI-R, it is of interest to expand the ways in which information obtained from this interview is used. The current study examines how algorithm totals reflecting past (ADI-Diagnostic) and current (ADI-Current) behaviors are influenced by child characteristics, such as demographics, behavioral problems and developmental level. Children with less language at the time of the interview had higher ADI-Diagnostic and ADI-Current. ADI-Diagnostic totals were also associated with age; parents of older children reported more severe past behaviors. Recommendations are provided regarding the use of the ADI-R as a measure of ASD severity, taking language and age into account.
C1 [Hus, Vanessa] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
   [Lord, Catherine] Weill Cornell Med Coll, Ctr Autism & Dev Brain, White Plains, NY USA.
   [Lord, Catherine] NY Presbyterian Hosp, White Plains, NY USA.
RP Hus, V (reprint author), Univ Michigan, Dept Psychol, 530 Church St, Ann Arbor, MI 48109 USA.
EM vhus@umich.edu
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2012, DSM 5 DEV
   Bishop D. V. M., 2003, CHILDRENS COMMUNICAT
   Bishop SL, 2006, CHILD NEUROPSYCHOL, V12, P247, DOI 10.1080/09297040600630288
   Charman T, 2007, BRIT J PSYCHIAT, V191, P554, DOI 10.1192/bjp.bp.107.040196
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Constantino JN, 2003, J AM ACAD CHILD PSY, V42, P458, DOI 10.1097/01.CHI.0000046811.95464.21
   Coutanche MN, 2011, NEUROIMAGE, V57, P113, DOI 10.1016/j.neuroimage.2011.04.016
   Cunningham AB, 2012, J AUTISM DEV DISORD, V42, P593, DOI 10.1007/s10803-011-1280-3
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   de Bildt A, 2004, J AUTISM DEV DISORD, V34, P129
   De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
   Duvall JA, 2007, AM J PSYCHIAT, V164, P656, DOI 10.1176/appi.ajp.164.4.656
   Elliott C., 2007, DIFFERENTIAL ABILITY
   Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
   Frazier TW, 2008, J AUTISM DEV DISORD, V38, P474, DOI 10.1007/s10803-007-0415-z
   Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Holtmann M, 2007, DEV MED CHILD NEUROL, V49, P361
   Hus V, 2011, J CHILD PSYCHOL PSYC, V52, P753, DOI 10.1111/j.1469-7610.2011.02398.x
   Hus V, 2007, BIOL PSYCHIAT, V61, P438, DOI 10.1016/j.biopsych.2006.08.044
   Hus V., J CHILD PSY IN PRESS
   Kaiser MD, 2010, P NATL ACAD SCI USA, V107, P21223, DOI 10.1073/pnas.1010412107
   Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   Mayes SD, 2011, RES AUTISM SPECT DIS, V5, P749, DOI 10.1016/j.rasd.2010.09.002
   Meilleur AAS, 2009, J INTELL DISABIL RES, V53, P115, DOI 10.1111/j.1365-2788.2008.01134.x
   Mullen E, 1995, MULLEN SCALES EARLY
   NDAR, 2010, NATL DATABASE AUTISM
   Piven J, 1996, J AM ACAD CHILD PSY, V35, P523, DOI 10.1097/00004583-199604000-00019
   Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265
   Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rutter M., 2003, SOCIAL COMMUNICATION
   Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b
   Simons Foundation, 2011, SIM SIMPL COLL
   Uddin L. Q., 2011, BIOL PSYCHIAT
   Wechsler D., 2003, WECHSLER INTELLIGENC
   Wechsler D, 1999, WECHSLER ABBREVIATED
   World Health Organization, 2011, INT STAT CLASS DIS R
NR 42
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 371
EP 381
DI 10.1007/s10803-012-1576-y
PG 11
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600009
PM 22729382
ER

PT J
AU White, SW
   Ollendick, T
   Albano, AM
   Oswald, D
   Johnson, C
   Southam-Gerow, MA
   Kim, I
   Scahill, L
AF White, Susan W.
   Ollendick, Thomas
   Albano, Anne Marie
   Oswald, Donald
   Johnson, Cynthia
   Southam-Gerow, Michael A.
   Kim, Inyoung
   Scahill, Lawrence
TI Randomized Controlled Trial: Multimodal Anxiety and Social Skill
   Intervention for Adolescents with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Anxiety; Adolescence; Treatment
ID COGNITIVE-BEHAVIORAL THERAPY; HIGH-FUNCTIONING AUTISM; PERVASIVE
   DEVELOPMENTAL DISORDERS; COMORBID PSYCHIATRIC-DISORDERS;
   ASPERGER-SYNDROME; CLINICAL-TRIAL; CHILDHOOD ANXIETY; CHILDREN;
   DEPRESSION; YOUTH
AB Anxiety is common among adolescents with autism spectrum disorders (ASD) and may amplify the core social disability, thus necessitating combined treatment approaches. This pilot, randomized controlled trial evaluated the feasibility and preliminary outcomes of the Multimodal Anxiety and Social Skills Intervention (MASSI) program in a sample of 30 adolescents with ASD and anxiety symptoms of moderate or greater severity. The treatment was acceptable to families, subject adherence was high, and therapist fidelity was high. A 16 % improvement in ASD social impairment (within-group effect size = 1.18) was observed on a parent-reported scale. Although anxiety symptoms declined by 26 %, the change was not statistically significant. These findings suggest MASSI is a feasible treatment program and further evaluation is warranted.
C1 [White, Susan W.; Ollendick, Thomas] Virginia Polytech Inst & State Univ, Dept Psychol, Blacksburg, VA 24061 USA.
   [Albano, Anne Marie] Columbia Univ, Columbia Clin Anxiety & Related Disorders, New York, NY USA.
   [Oswald, Donald] Virginia Commonwealth Univ, Commonwealth Autism Serv, Richmond, VA USA.
   [Johnson, Cynthia] Univ Pittsburgh, Sch Med, Autism Ctr, Pittsburgh, PA USA.
   [Southam-Gerow, Michael A.] Virginia Commonwealth Univ, Dept Psychol, Richmond, VA 23284 USA.
   [Southam-Gerow, Michael A.] Virginia Commonwealth Univ, Dept Pediat, Richmond, VA USA.
   [Kim, Inyoung] Virginia Polytech Inst & State Univ, Dept Stat, Blacksburg, VA 24061 USA.
   [Scahill, Lawrence] Yale Univ, Sch Nursing, Yale Child Study Ctr, New Haven, CT 06536 USA.
RP White, SW (reprint author), Virginia Polytech Inst & State Univ, Dept Psychol, 109 Williams Hall,0436, Blacksburg, VA 24061 USA.
EM sww@vt.edu
CR Barrett PM, 1996, J CONSULT CLIN PSYCH, V64, P333, DOI 10.1037/0022-006X.64.2.333
   Bass M, 2009, J AUTISM DEV DISORD, V39, P1261, DOI 10.1007/s10803-009-0734-3
   Beaumont R, 2008, J CHILD PSYCHOL PSYC, V49, P743, DOI 10.1111/j.1469-7610.2008.01920.x
   Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201
   Brown TA, 2009, BEHAV RES THER, V47, P487, DOI 10.1016/j.brat.2009.02.016
   Campbell JM, 2004, RES DEV DISABIL, V25, P321, DOI 10.1016/j.ridd.2004.01.005
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Chambless DL, 1998, J CONSULT CLIN PSYCH, V66, P7, DOI 10.1037//0022-006X.66.1.7
   Chorpita B. F, 2007, GUIDES INDIVIDUALIZE
   CLARK LA, 1991, J ABNORM PSYCHOL, V100, P316, DOI 10.1037/0021-843X.100.3.316
   CLARKE G, 1992, BEHAV THER, V23, P341, DOI 10.1016/S0005-7894(05)80162-5
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Costello E. J, 2004, PHOBIC ANXIETY DISOR
   Dalton KM, 2007, BIOL PSYCHIAT, V61, P512, DOI 10.1016/j.biopsych.2006.05.019
   de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x
   Fidler F., 2008, EVIDENCE BASED OUTCO, P315
   Gadow K. D., 1997, ADOLESCENT SYMPTOM I
   Gadow K. D., 1998, ADOLESCENT SYMPTOM I
   Gaynor ST, 2006, BEHAV MODIF, V30, P647, DOI 10.1177/0145445504272979
   Guy W, 1976, 76338 US DHEW ADM, V76-338, P218
   Harnum M, 2007, J AUTISM DEV DISORD, V37, P1337, DOI 10.1007/s10803-006-0273-0
   Honda H, 2005, DEV MED CHILD NEUROL, V47, P10, DOI 10.1017/S0012162205000034
   Hudson JL, 2009, J AM ACAD CHILD PSY, V48, P533, DOI 10.1097/CHI.0b013e31819c2401
   JACOBSON NS, 1991, J CONSULT CLIN PSYCH, V59, P12, DOI 10.1037//0022-006X.59.1.12
   Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
   Joshi G, 2010, J AUTISM DEV DISORD, V40, P1361, DOI 10.1007/s10803-010-0996-9
   Kendall PC, 1997, J CONSULT CLIN PSYCH, V65, P366, DOI 10.1037/0022-006X.65.3.366
   Kendall PC, 2008, J CONSULT CLIN PSYCH, V76, P282, DOI 10.1037/0022-006X.76.2.282
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Kleinhans NM, 2010, NEUROPSYCHOLOGIA, V48, P3665, DOI 10.1016/j.neuropsychologia.2010.07.022
   Kraemer HC, 2006, BIOL PSYCHIAT, V59, P990, DOI 10.1016/j.biopsych.2005.09.014
   Kraemer HC, 2006, ARCH GEN PSYCHIAT, V63, P484, DOI 10.1001/archpsyc.63.5.484
   Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
   Leon AC, 2011, J PSYCHIATR RES, V45, P626, DOI 10.1016/j.jpsychires.2010.10.008
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lopata C, 2010, J AUTISM DEV DISORD, V40, P1297, DOI 10.1007/s10803-010-0989-8
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   March J, 2004, JAMA-J AM MED ASSOC, V292, P807
   Mazefsky C. A., 2012, INT M AUT RES TOR CA
   Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Morris SB, 2002, PSYCHOL METHODS, V7, P105, DOI 10.1037//1082-989X.7.1.105
   Myles BS, 2001, EDUC TRAIN MENT RET, V36, P304
   Ochs E, 2001, SOC DEV, V10, P399, DOI 10.1111/1467-9507.00172
   Ollendick TH, 2009, J CONSULT CLIN PSYCH, V77, P504, DOI 10.1037/a0015158
   Pavuluri MN, 2004, J AM ACAD CHILD PSY, V43, P528, DOI 10.1097/01.chi.0000116743.71662.f8
   PITMAN E. J. G., 1937, ROYAL STAT SOC S, V4, P225
   Pocock SJ, 1983, CLIN TRIALS PRACTICA
   Reaven JA, 2009, FOCUS AUTISM DEV DIS, V24, P27, DOI 10.1177/1088357608327666
   Research Unit on Pediatric Psychopharmacology Anxiety Study Group, 2002, J AM ACAD CHILD ADOL, V41, P1061, DOI DOI 10.1097/00004583-200209000-00006
   Butter EM, 2007, BEHAV INTERVENT, V22, P179, DOI 10.1002/bin.236
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Shatayermann O, 2007, ISSUES COMPREHENSIVE, V30, P87, DOI [10.1080/01460860701525089, DOI 10.1080/01460860701525089]
   Silverman W. K., 1996, ANXIETY DISORDERS IN
   Silverman WK, 2001, J AM ACAD CHILD PSY, V40, P937, DOI 10.1097/00004583-200108000-00016
   Silverman WK, 1999, J CONSULT CLIN PSYCH, V67, P675, DOI 10.1037/0022-006X.67.5.675
   Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Sparrow S., 2005, VINELAND 2 ADAPTIVE, V2nd
   Stattin H, 2009, J ADOLESCENCE, V32, P1437, DOI 10.1016/j.adolescence.2009.10.010
   Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
   Swaim KF, 2001, J AUTISM DEV DISORD, V31, P195, DOI 10.1023/A:1010703316365
   Trosper SE, 2012, J ABNORM CHILD PSYCH, V40, P621, DOI 10.1007/s10802-011-9582-7
   Tse J, 2007, J AUTISM DEV DISORD, V37, P1960, DOI 10.1007/s10803-006-0343-3
   United States Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61
   Volkmar F. R., 2000, ASPERGER SYNDROME, P340
   Wagner A, 2007, BIOL PSYCHIAT, V61, P504, DOI 10.1016/j.biopsych.2007.01.001
   Walkup JT, 2008, NEW ENGL J MED, V359, P2753, DOI 10.1056/NEJMoa0804633
   Wechsler D, 1999, WECHSLER ABBREVIATED
   White SW, 2009, J AUTISM DEV DISORD, V39, P1652, DOI 10.1007/s10803-009-0801-9
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   White SW, 2010, CLIN CHILD FAM PSYCH, V13, P77, DOI 10.1007/s10567-009-0062-3
   White SW, 2010, FOCUS AUTISM DEV DIS, V25, P209, DOI 10.1177/1088357610380595
   White SW, 2012, J AUTISM DEV DISORD, V42, P1138, DOI 10.1007/s10803-011-1353-3
   Witwer AN, 2010, J DEV PHYS DISABIL, V22, P367, DOI 10.1007/s10882-010-9194-0
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Wood JW, 2002, TLS-TIMES LIT SUPPL, P31
NR 78
TC 24
Z9 24
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 382
EP 394
DI 10.1007/s10803-012-1577-x
PG 13
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600010
PM 22735897
ER

PT J
AU Katagiri, M
   Kasai, T
   Kamio, Y
   Murohashi, H
AF Katagiri, Masatoshi
   Kasai, Tetsuko
   Kamio, Yoko
   Murohashi, Harumitsu
TI Individuals with Asperger's Disorder Exhibit Difficulty in Switching
   Attention from a Local Level to a Global Level
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Asperger's disorder; Level-repetition; Switching; Global; Local
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; WEAK COHERENCE; PERCEPTION;
   DEFICIT; INTERFERENCE; PRECEDENCE; FEATURES; CHILDREN; FOREST
AB The purpose of the present study was to determine whether individuals with Asperger's disorder exhibit difficulty in switching attention from a local level to a global level. Eleven participants with Asperger's disorder and 11 age- and gender-matched healthy controls performed a level-repetition switching task using Navon-type hierarchical stimuli. In both groups, level-repetition was beneficial at both levels. Furthermore, individuals with Asperger's disorder exhibited difficulty in switching attention from a local level to a global level compared to control individuals. These findings suggested that there is a problem with the inhibitory mechanism that influences the output of enhanced local visual processing in Asperger's disorder.
C1 [Katagiri, Masatoshi] Toyama Univ, Dept Neuropsychiat & Neuropsychol, Grad Sch Med, Toyama 9300194, Japan.
   [Katagiri, Masatoshi; Kamio, Yoko] Natl Ctr Neurol & Psychiat, Dept Child & Adolescent Mental Hlth, Natl Inst Mental Hlth, Tokyo, Japan.
   [Kasai, Tetsuko; Murohashi, Harumitsu] Hokkaido Univ, Fac Educ, Sapporo, Hokkaido, Japan.
RP Katagiri, M (reprint author), Toyama Univ, Dept Neuropsychiat & Neuropsychol, Grad Sch Med, 2630 Sugitani, Toyama 9300194, Japan.
EM katagiri@las.u-toyama.ac.jp
CR Akshoomoff N, 2005, DEV NEUROPSYCHOL, V27, P307, DOI 10.1207/s15326942dn2703_1
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   DiCicco-Bloom E, 2006, J NEUROSCI, V26, P6897, DOI 10.1523/JNEUROSCI.1712-06.2006
   Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Happe FGE, 2008, Q J EXP PSYCHOL, V61, P50, DOI 10.1080/17470210701508731
   Jarrold C, 2000, DEV PSYCHOL, V36, P126, DOI 10.1037/0012-1649.36.1.126
   Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
   KIMCHI R, 1992, PSYCHOL BULL, V112, P24, DOI 10.1037/0033-2909.112.1.24
   Lamb MR, 1996, PERCEPT PSYCHOPHYS, V58, P363, DOI 10.3758/BF03206812
   Lamb MR, 1998, PSYCHOL SCI, V9, P14, DOI 10.1111/1467-9280.00003
   Mann TA, 2003, J CHILD PSYCHOL PSYC, V44, P274, DOI 10.1111/1469-7610.00120
   Mottron L, 2003, J CHILD PSYCHOL PSYC, V44, P904, DOI 10.1111/1469-7610.00174
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3
   OZONOFF S, 1994, J CHILD PSYCHOL PSYC, V35, P1015, DOI 10.1111/j.1469-7610.1994.tb01807.x
   Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489
   Rinehart NJ, 2001, AUTISM, V5, P67, DOI 10.1177/1362361301005001007
   Rinehart NJ, 2000, J CHILD PSYCHOL PSYC, V41, P769, DOI 10.1017/S002196309900596X
   Robertson LC, 1996, J EXP PSYCHOL GEN, V125, P227, DOI 10.1037//0096-3445.125.3.227
   Scherf KS, 2008, AUTISM RES, V1, P114, DOI 10.1002/aur.17
   SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Wang LX, 2007, COGN NEUROPSYCHOL, V24, P550, DOI 10.1080/13546800701417096
   Wilkinson DT, 2001, NEUROIMAGE, V13, P56, DOI 10.1006/nimg.2000.0678
NR 25
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 395
EP 403
DI 10.1007/s10803-012-1578-9
PG 9
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600011
PM 22729383
ER

PT J
AU Williams, D
   Payne, H
   Marshall, C
AF Williams, David
   Payne, Heather
   Marshall, Chloe
TI Non-word Repetition Impairment in Autism and Specific Language
   Impairment: Evidence for Distinct Underlying Cognitive Causes
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Specific language impairment; Non-word repetition; Clinical
   markers
ID SHORT-TERM-MEMORY; NONWORD REPETITION; INFANTILE-AUTISM; SPECTRUM
   DISORDERS; INNER SPEECH; FOLLOW-UP; CHILDREN; DEFICITS; DYSLEXIA; RISK
AB Language-impaired individuals with autism perform poorly on tests such as non-word repetition that are sensitive clinical markers of specific language impairment (SLI). This has fuelled the theory that language impairment in autism represents a co-morbid SLI. However, the underlying cause of these deficits may be different in each disorder. In a novel task, we manipulated non-word stimuli in three ways known to influence the repetition accuracy of children with SLI. Participants with SLI were affected differently by these manipulations to children with autism. Children with autism performed similarly to language-matched typical children in terms of levels and patterns of performance, and types of error made, suggesting that the underlying cognitive cause of non-word repetition deficits is different in each disorder.
C1 [Williams, David] Univ Durham, Dept Psychol, Durham DH1 3LE, England.
   [Payne, Heather] City Univ London, Dept Language & Commun Sci, London EC1V 0HB, England.
   [Marshall, Chloe] Univ London, Dept Psychol & Human Dev, Inst Educ, London WC1H 0AA, England.
RP Williams, D (reprint author), Univ Durham, Dept Psychol, Durham DH1 3LE, England.
EM david.williams@durham.ac.uk; c.marshall@ioe.ac.uk
RI Williams, David/B-9804-2013
CR Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Archibald LMD, 2007, PSYCHON B REV, V14, P919, DOI 10.3758/BF03194122
   Archibald LMD, 2006, J SPEECH LANG HEAR R, V49, P970, DOI 10.1044/1092-4388(2006/070)
   Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
   GATHERCOLE SE, 1990, J MEM LANG, V29, P336, DOI 10.1016/0749-596X(90)90004-J
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Ballarati L, 2009, EUR J MED GENET, V52, P218, DOI 10.1016/j.ejmg.2009.02.004
   Barry JG, 2007, GENES BRAIN BEHAV, V6, P66, DOI 10.1111/j.1601-183X.2006.00232.x
   BARTAK L, 1975, BRIT J PSYCHIAT, V126, P127, DOI 10.1192/bjp.126.2.127
   BARTAK L, 1977, J AUTISM CHILD SCHIZ, V7, P383, DOI 10.1007/BF01540396
   Bishop D, 2011, ARE OUR GOLD STANDAR
   Bishop DVM, 2010, BEHAV GENET, V40, P618, DOI 10.1007/s10519-010-9381-x
   Bishop DVM, 2004, PSYCHOL BULL, V130, P858, DOI 10.1037/0033-2909.130.6.858
   Bishop DVM, 2004, AM J MED GENET B, V128B, P54, DOI 10.1002/ajmg.b.30039
   Bishop DVM, 1996, J CHILD PSYCHOL PSYC, V37, P391, DOI 10.1111/j.1469-7610.1996.tb01420.x
   Botting N, 2005, J CHILD PSYCHOL PSYC, V46, P317, DOI 10.1111/j.1469-7610.2004.00355.x
   BOUCHER J, 1976, BRIT J PSYCHOL, V67, P73
   Butcher L. M., 2006, CURRENT OPINION NEUR, V16, P5
   Catts HW, 2005, J SPEECH LANG HEAR R, V48, P1378, DOI 10.1044/1092-4388(2005/096)
   Coady JA, 2008, INT J LANG COMM DIS, V43, P1, DOI 10.1080/13682820601116485
   Conti-Ramsden G, 2001, INT J LANG COMM DIS, V36, P207, DOI 10.1080/13682820010019883
   Conti-Ramsden G, 2003, INT J LANG COMM DIS, V38, P251, DOI 10.1080/1368282031000092339
   Elia J, 2010, MOL PSYCHIATR, V15, P637, DOI 10.1038/mp.2009.57
   Gallon N, 2007, CLIN LINGUIST PHONET, V21, P435, DOI 10.1080/02699200701299982
   GATHERCOLE SE, 1991, APPL PSYCHOLINGUIST, V12, P349, DOI 10.1017/S0142716400009267
   Goldman R, 2000, GOLDMAN FRISTOE TEST
   LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Leonard L. B., 2000, SPEECH LANGUAGE IMPA, P115
   Lindgren KA, 2009, AUTISM RES, V2, P22, DOI 10.1002/aur.63
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Marshall C. R., 2003, P U CAMBR 1 POSTGR C, V1, P511
   Marshall CR, 2009, LANGUAGE, V85, P39
   Mawhood L, 2000, J CHILD PSYCHOL PSYC, V41, P547, DOI 10.1017/S002196309900579X
   Morton J., 1995, DEV PSYCHOPATHOL, P357
   Newbury DF, 2011, BEHAV GENET, V41, P90, DOI 10.1007/s10519-010-9424-3
   Newbury DF, 2009, AM J HUM GENET, V85, P264, DOI 10.1016/j.ajhg.2009.07.004
   RICE ML, 1995, J SPEECH HEAR RES, V38, P850
   Riches NG, 2011, J COMMUN DISORD, V44, P23, DOI 10.1016/j.jcomdis.2010.06.003
   Rutter M., 2003, SOCIAL COMMUNICATION
   Scerri TS, 2011, BIOL PSYCHIAT, V70, P237, DOI 10.1016/j.biopsych.2011.02.005
   Semel E., 2006, CLIN EVALUATION LANG, V4th
   Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008
   SNOWLING M, 1991, APPL PSYCHOLINGUIST, V12, P369, DOI 10.1017/S0142716400009279
   Tager-Flusberg H, 2004, J AUTISM DEV DISORD, V34, P75, DOI 10.1023/B:JADD.0000018077.64617.5a
   Tomblin JB, 1997, J SPEECH LANG HEAR R, V40, P1245
   VANDERLELY HKJ, 1993, J SPEECH HEAR RES, V36, P1193
   Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
   Wechsler D., 2004, WECHSLER INTELLIGENC
   Whitehouse AJO, 2011, GENES BRAIN BEHAV, V10, P451, DOI 10.1111/j.1601-183X.2011.00684.x
   Whitehouse AJO, 2008, J COMMUN DISORD, V41, P319, DOI 10.1016/j.jcomdis.2008.01.002
   Williams D, 2008, J CHILD PSYCHOL PSYC, V49, P51, DOI 10.1111/j.1469-7610.2007.01836.x
   Williams D, 2008, PSYCHOL BULL, V134, P944, DOI [10.1037/a0013743, 10.1037/0013743]
   Williams D. M., 2013, CURRENT ISSUES DEV D, P19
   Williams DM, 2012, DEV PSYCHOPATHOL, V24, P225, DOI 10.1017/S0954579411000794
NR 56
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 404
EP 417
DI 10.1007/s10803-012-1579-8
PG 14
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600012
PM 22733298
ER

PT J
AU Paul, R
   Campbell, D
   Gilbert, K
   Tsiouri, I
AF Paul, Rhea
   Campbell, Daniel
   Gilbert, Kimberly
   Tsiouri, Ioanna
TI Comparing Spoken Language Treatments for Minimally Verbal Preschoolers
   with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Language; Treatment; Intervention; Communication; Speech
ID YOUNG-CHILDREN; PROBING INTERACTIONS; BEHAVIORAL MOMENTUM;
   COMMUNICATION; TODDLERS; SPEECH; INFANT; INTERVENTIONS; PREFERENCES;
   REGRESSION
AB Preschoolers with severe autism and minimal speech were assigned either a discrete trial or a naturalistic language treatment, and parents of all participants also received parent responsiveness training. After 12 weeks, both groups showed comparable improvement in number of spoken words produced, on average. Approximately half the children in each group achieved benchmarks for the first stage of functional spoken language development, as defined by Tager-Flusberg et al. (J Speech Lang Hear Res, 52: 643-652, 2009). Analyses of moderators of treatment suggest that joint attention moderates response to both treatments, and children with better receptive language pre-treatment do better with the naturalistic method, while those with lower receptive language show better response to the discrete trial treatment. The implications of these findings are discussed.
C1 [Paul, Rhea] Sacred Heart Univ, Dept Speech Language Pathol, Coll Hlth Profess, Fairfield, CT 06825 USA.
   [Campbell, Daniel] Yale Child Study Ctr, New Haven, CT 06510 USA.
   [Gilbert, Kimberly] Hofstra Univ, Hempstead, NY 11550 USA.
   [Tsiouri, Ioanna] Larisa Univ Hosp, Larisa, Greece.
RP Paul, R (reprint author), Sacred Heart Univ, Dept Speech Language Pathol, Coll Hlth Profess, 5151 Pk Ave, Fairfield, CT 06825 USA.
EM PaulR4@SacredHeart.edu
CR Aldred C, 2012, J AUTISM DEV DISORD, V42, P447, DOI 10.1007/s10803-011-1248-3
   BaronCohen S, 1997, CHILD DEV, V68, P48
   Bauer DJ, 2005, MULTIVAR BEHAV RES, V40, P373, DOI 10.1207/s15327906mbr4003_5
   Christensen-Sandfort RJ, 2013, TOP EARLY CHILD SPEC, V32, P211, DOI 10.1177/0271121411404930
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
   Delprato DJ, 2001, J AUTISM DEV DISORD, V31, P315, DOI 10.1023/A:1010747303957
   Fenson L., 2007, MACARTHUR BATES COMM
   Fey M., 1986, LANGUAGE INTERVENTIO
   Gernsbacher MA, 2008, J CHILD PSYCHOL PSYC, V49, P43, DOI 10.1111/j.1469-7610.2007.01820.x
   Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
   Hancock TB, 2002, TOP EARLY CHILD SPEC, V22, P39, DOI 10.1177/027112140202200104
   HART B, 1975, J APPL BEHAV ANAL, V8, P411, DOI 10.1901/jaba.1975.8-411
   Hester P. P., 1995, J EARLY INTERVENTION, V20, P30
   Howlin P., 2005, HDB AUTISM PERVASIVE, V1, P201
   Kaiser A, 2010, INSTRUCTION STUDENTS
   Kaiser A. P., 1992, CAUSES EFFECTS COMMU, V1, P9
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   MACE FC, 1990, J APPL BEHAV ANAL, V23, P507, DOI 10.1901/jaba.1990.23-507
   MACE FC, 1990, J EXP ANAL BEHAV, V54, P163, DOI 10.1901/jeab.1990.54-163
   MELTZOFF AN, 1988, DEV PSYCHOL, V24, P470, DOI 10.1037//0012-1649.24.4.470
   Mullen E, 1995, MULLEN SCALES EARLY
   MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861
   National Research Council, 2001, ED CHILDR AUT
   NEVIN JA, 1983, J EXP ANAL BEHAV, V39, P49, DOI 10.1901/jeab.1983.39-49
   Owens R., 2009, LANGUAGE DISORDERS F
   Paul R, 2008, CHILD ADOL PSYCH CL, V17, P835, DOI 10.1016/j.chc.2008.06.011
   Paul R, 2009, ASHA LEADER, V14, P10
   Paul R, 2011, J CHILD PSYCHOL PSYC, V52, P588, DOI 10.1111/j.1469-7610.2010.02332.x
   Paul R, 2007, J SPEECH LANG HEAR R, V50, P1350, DOI 10.1044/1092-4388(2007/094)
   Paul R., 2005, HDB AUTISM PERVASIVE, V1, P946
   Paul R, 2008, AUTISM RES, V1, P97, DOI 10.1002/aur.12
   Preacher KJ, 2006, J EDUC BEHAV STAT, V31, P437, DOI 10.3102/10769986031004437
   Prelock PA, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P93, DOI 10.1007/978-1-4419-6975-0_5
   Prizant B., 2005, CRITICAL ISSUES ENHA, V1, P925
   Reichow B, 2009, J AUTISM DEV DISORD, V39, P23, DOI 10.1007/s10803-008-0596-0
   Rogers S, 2006, SOCIAL COMMUNICATION, P143
   Rogers S. J., 2005, HDB AUTISM PERVASIVE, V1, P382
   ROGERSWARREN A, 1980, BEHAV MODIF, V4, P361, DOI 10.1177/014544558043006
   Ross DE, 2003, RES DEV DISABIL, V24, P58, DOI 10.1016/S0891-4222(02)00167-1
   Schoen E, 2011, AUTISM RES, V4, P177, DOI 10.1002/aur.183
   Schoen E., 2009, CHILD SPEECH SOUND D
   Shriberg LD, 2011, J AUTISM DEV DISORD, V41, P405, DOI 10.1007/s10803-010-1117-5
   Skinner B. F., 1957, VERBAL BEHAV
   Smith T., 2001, FOCUS AUTISM OTHER D, V16, P86, DOI 10.1177/108835760101600204
   Sparrow S. S., 2005, VINELAND ADAPTIVE BE
   SPRADLIN JE, 1982, J SPEECH HEAR DISORD, V47, P2
   STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
   Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136)
   Tsiouri I., 2012, RAPID MOTOR IMITATIO
   Tsiouri I., 2003, J BEHAV ED, V12, P185, DOI DOI 10.1023/A:1025508311022
   Tsiouri I, 2002, DISS ABSTR INT A, V63
   Tsiouri I., 2012, J AUTISM DE IN PRESS, P42
   Velleman S., 2009, SPEECH SOUND DISORDE
   Warren S. F., 1998, TRANSITIONS PRELINGU, P365
   Watt N, 2006, J SPEECH LANG HEAR R, V49, P1224, DOI 10.1044/1092-4388(2006/088)
   Wetherby A., 2003, COMMUNICATION SYMBOL
   Yoder P, 2006, J CONSULT CLIN PSYCH, V74, P426, DOI 10.1037/0022-006X.74.3.426
   Yoder PJ, 2002, J SPEECH LANG HEAR R, V45, P1158, DOI 10.1044/1092-4388(2002/094)
NR 60
TC 10
Z9 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 418
EP 431
DI 10.1007/s10803-012-1583-z
PG 14
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600013
PM 22733301
ER

PT J
AU Allen, R
   Davis, R
   Hill, E
AF Allen, Rory
   Davis, Rob
   Hill, Elisabeth
TI The Effects of Autism and Alexithymia on Physiological and Verbal
   Responsiveness to Music
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Music; Alexithymia; Emotion
ID SPECTRUM DISORDERS; RESPONSES; EMOTIONS; CHILDREN; ADULTS; ADOLESCENTS;
   EXPERIENCE; VALIDITY; NOISE
AB It has been suggested that individuals with autism will be less responsive to the emotional content of music than typical individuals. With the aim of testing this hypothesis, a group of high-functioning adults on the autism spectrum was compared with a group of matched controls on two measures of emotional responsiveness to music, comprising physiological and verbal measures. Impairment in participants ability to verbalize their emotions (type-II alexithymia) was also assessed. The groups did not differ significantly on physiological responsiveness, but the autism group was significantly lower on the verbal measure. However, inclusion of the alexithymia score as a mediator variable nullified this group difference, suggesting that the difference was due not to absence of underlying emotional responsiveness to music in autism, but to a reduced ability to articulate it.
C1 [Allen, Rory; Davis, Rob; Hill, Elisabeth] Univ London, Dept Psychol, London SE14 6NW, England.
RP Allen, R (reprint author), Univ London, Dept Psychol, Whitehead Bldg, London SE14 6NW, England.
EM r.allen@gold.ac.uk; r.davis@gold.ac.uk; e.hill@gold.ac.uk
RI Allen, Rory/E-8660-2011
OI Allen, Rory/0000-0003-3434-9772
CR Allen R, 2009, AUTISM, V13, P21, DOI 10.1177/1362361307098511
   Allen R, 2010, MUSIC PERCEPT, V27, P251, DOI 10.1525/MP.2010.27.4.251
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Begeer S, 2008, DEV REV, V28, P342, DOI 10.1016/j.dr.2007.09.001
   Berthoz S, 2005, EUR PSYCHIAT, V20, P291, DOI 10.1016/j.eurpsy.2004.06.013
   Bhatara AK, 2009, CHILD NEUROPSYCHOL, V15, P375, DOI 10.1080/09297040802603653
   Bird G, 2010, BRAIN, V133, P1515, DOI 10.1093/brain/awq060
   Blood AJ, 2001, P NATL ACAD SCI USA, V98, P11818, DOI 10.1073/pnas.191355898
   Carlson S, 1997, NEUROREPORT, V8, P2853, DOI 10.1097/00001756-199709080-00010
   Dellacherie D, 2010, PSYCHOPHYSIOLOGY, V48, P337
   Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd
   Falkmer M, 2011, BIOL PSYCHIAT, V70, P812, DOI 10.1016/j.biopsych.2011.07.025
   Fritz T, 2009, CURR BIOL, V19, P573, DOI 10.1016/j.cub.2009.02.058
   Hala S, 2007, J AUTISM DEV DISORD, V37, P329, DOI 10.1007/s10803-006-0162-6
   Harvey DI, 2009, ECONOMET THEOR, V25, P995, DOI 10.1017/S0266466608090385
   Heaton P, 2009, BRAIN, V132, P2897
   Heaton P, 1999, PSYCHOL MED, V29, P1405, DOI 10.1017/S0033291799001221
   Heaton P, 2008, BRIT J DEV PSYCHOL, V26, P171, DOI 10.1348/026151007X206776
   Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
   Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14
   Howell D. C., 2012, STAT METHODS PSYCHOL, V8th
   Huron D, 2001, ANN NY ACAD SCI, V930, P43
   iWorx, 2011, IWORX PSYCH LAB MAN
   Juslin P. N., 2010, HDB MUSIC EMOTION TH
   Juslin PN, 2008, BEHAV BRAIN SCI, V31, P559, DOI 10.1017/S0140525X08005293
   Khalfa S, 2002, NEUROSCI LETT, V328, P145, DOI 10.1016/S0304-3940(02)00462-7
   Khalfa S, 2004, HEARING RES, V198, P87, DOI 10.1016/j.heares.2004.07.006
   Kim J, 2008, IEEE T PATTERN ANAL, V30, P2067, DOI 10.1109/TPAMI.2008.26
   Koelsch S, 2010, TRENDS COGN SCI, V14, P131, DOI 10.1016/j.tics.2010.01.002
   Koneeni V. J., 2005, B PSYCHOL ARTS, V5, P27
   Krumhansl CL, 1997, CAN J EXP PSYCHOL, V51, P336, DOI 10.1037/1196-1961.51.4.336
   Levitin Daniel, 2006, THIS IS YOUR BRAIN M
   Lombardo M.V., 2007, PLOS ONE, V2
   Lutkenhoner B, 2006, NEUROIMAGE, V30, P927, DOI 10.1016/jneuroimiage.2005.10.034
   Main IG, 1999, GEOPHYS RES LETT, V26, P2801, DOI 10.1029/1999GL005372
   McGregor KK, 2012, J SPEECH LANG HEAR R, V55, P70, DOI 10.1044/1092-4388(2011/11-0024)
   Mottron L, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P131
   Mottron L, 2000, J CHILD PSYCHOL PSYC, V41, P1057, DOI 10.1017/S0021963099006253
   North AC, 2004, MUSIC PERCEPT, V22, P41, DOI 10.1525/mp.2004.22.1.41
   North AC, 2000, BRIT J EDUC PSYCHOL, V70, P255, DOI 10.1348/000709900158083
   Peretz I, 2001, MUSIC EMOTION
   Plaisted KC, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P149
   Quintin EM, 2011, J AUTISM DEV DISORD, V41, P1240, DOI 10.1007/s10803-010-1146-0
   Salimpoor VN, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007487
   Salimpoor VN, 2011, NAT NEUROSCI, V14, P257, DOI 10.1038/nn.2726
   Schaefer F, 2000, PSYCHOPHYSIOLOGY, V37, P85
   Soulieres I, 2011, Q J EXP PSYCHOL, V64, P311, DOI 10.1080/17470218.2010.492994
   Stewart L, 2011, Q J EXP PSYCHOL, V64, P625, DOI 10.1080/17470218.2011.552730
   Vorst HCM, 2001, PERS INDIV DIFFER, V30, P413, DOI 10.1016/S0191-8869(00)00033-7
   Zentner M, 2008, EMOTION, V8, P494, DOI 10.1037/1528-3542.8.4.494
NR 53
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 432
EP 444
DI 10.1007/s10803-012-1587-8
PG 13
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600014
PM 22752845
ER

PT J
AU Potvin, MC
   Snider, L
   Prelock, P
   Kehayia, E
   Wood-Dauphinee, S
AF Potvin, Marie-Christine
   Snider, Laurie
   Prelock, Patricia
   Kehayia, Eva
   Wood-Dauphinee, Sharon
TI Recreational Participation of Children with High Functioning Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Recreation; Leisure; Autism; Autistic disorder; Asperger disorder;
   Pervasive developmental disorder
ID QUALITY-OF-LIFE; SCHOOL-AGED CHILDREN; ASPERGER-SYNDROME;
   SPECTRUM-DISORDER; PARENTS PERSPECTIVES; LEISURE ACTIVITIES;
   RISK-FACTORS; ADOLESCENTS; PROFILES; PLAY
AB The recreation of children with High Functioning Autism (HFA) is not well understood. The objective of this cross-sectional study was to compare the recreational engagement of children with HFA and their typically developing peers. Children with HFA (n = 30) and peers (n = 31) were similar on key characteristics that may impact recreation except those related to the HFA attributes. Children with HFA differed from peers in terms of diversity (p = .002), social aspects (p = .006) and locations (p < .001) of recreation. The two groups were not statistically different in personal intensity (p = .684), enjoyment (p = .239) or preferences (p = .788) of recreation. A recreational profile was developed to benefit parents and clinicians in supporting the recreation of these children.
C1 [Potvin, Marie-Christine] Univ Vermont, Ctr Disabil & Community Inclus, Burlington, VT 05405 USA.
   [Snider, Laurie; Kehayia, Eva; Wood-Dauphinee, Sharon] McGill Univ, Sch Phys & Occupat Therapy, Montreal, PQ H3G 1Y5, Canada.
   [Prelock, Patricia] Univ Vermont, Coll Nursing & Hlth Sci, Burlington, VT 05405 USA.
RP Potvin, MC (reprint author), Univ Vermont, Ctr Disabil & Community Inclus, Man Hall,3rd Floor,208 Colchester Ave, Burlington, VT 05405 USA.
EM mpotvin@uvm.edu
CR Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6
   Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Bastiaansen D, 2004, J AM ACAD CHILD PSY, V43, P221, DOI 10.1097/01.chi.0000102684.30206.ad
   Bauminger N, 2003, J AUTISM DEV DISORD, V33, P489, DOI 10.1023/A:1025827427901
   Bedell G, 2008, J HEAD TRAUMA REHAB, V23, P220, DOI 10.1097/01.HTR.0000327254.61751.e7
   Bhasin TK, 2007, J AUTISM DEV DISORD, V37, P667, DOI 10.1007/s10803-006-0194-y
   Borremans E, 2010, ADAPT PHYS ACT Q, V27, P308
   Brown L., 1997, TEST NONVERBAL INTEL
   Carrow-Woolfolk E, 1999, COMPREHENSIVE ASSESS
   Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
   Curtin C., 2010, BMC PEDIAT, V10
   Maenner Matthew J, 2009, WMJ, V108, P253
   Fox L, 2002, EXCEPT CHILDREN, V68, P437
   Geschwind DH, 2008, CELL, V135, P391, DOI 10.1016/j.cell.2008.10.016
   Gilliam JE, 2006, GILLIAM AUTISM RATIN
   Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054
   Hilton CL, 2008, AM J OCCUP THER, V62, P554
   Hochhauser M, 2010, RES AUTISM SPECT DIS, V4, P746, DOI 10.1016/j.rasd.2010.01.015
   King G, 2004, CHILDRENS ASSESSMENT
   King Gillian, 2003, Physical & Occupational Therapy in Pediatrics, V23, P63, DOI 10.1300/J006v23n01_05
   King G, 2009, INT J DISABIL DEV ED, V56, P109, DOI 10.1080/10349120902868558
   Kolehmainen N, 2011, BMC PEDIATR, V11, DOI 10.1186/1471-2431-11-100
   Koning C, 2001, AUTISM, V5, P23, DOI 10.1177/1362361301005001003
   Landa RJ, 2005, J AUTISM DEV DISORD, V35, P557, DOI 10.1007/s10803-005-0001-1
   Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
   Lee LC, 2008, J AUTISM DEV DISORD, V38, P1147, DOI 10.1007/s10803-007-0491-0
   Linden M, 2009, PSYCHIAT DANUB, V21, P490
   Macintosh Kathleen, 2006, Autism, V10, P199, DOI 10.1177/1362361306062026
   Mactavish JB, 2004, J INTELL DISABIL RES, V48, P123, DOI 10.1111/j.1365-2788.2004.00502.x
   Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
   Mayes SD, 2003, AUTISM, V7, P65, DOI 10.1177/1362361303007001006
   Mazefsky CA, 2007, J AUTISM DEV DISORD, V37, P1086, DOI 10.1007/s10803-006-0251-6
   McConachie H, 2006, DISABIL REHABIL, V28, P1157, DOI 10.1080/09638280500534507
   Molloy CA, 2003, J AUTISM DEV DISORD, V33, P643, DOI 10.1023/B:JADD.0000006001.00667.4c
   Orsmond GI, 2004, J AUTISM DEV DISORD, V34, P245, DOI 10.1023/B:JADD.0000029547.96610.df
   Passmore A, 2003, OTJR-OCCUP PART HEAL, V23, P76
   Potvin MC, 2008, TOP LANG DISORD, V28, P365
   Public Health Agency of Canada, 2010, BEN PHYS ACT
   Public Health Agency of Canada, 2002, CAN PHYS ACT GUID HL
   Rinehart NJ, 2001, J AUTISM DEV DISORD, V31, P79, DOI 10.1023/A:1005617831035
   Rinehart NJ, 2006, EUR CHILD ADOLES PSY, V15, P256, DOI 10.1007/s00787-006-0530-y
   Rodriguez A, 2006, UPSALA J MED SCI, V111, P73
   Rutherford MD, 2007, J AUTISM DEV DISORD, V37, P1024, DOI 10.1007/s10803-006-0240-9
   Shikako-Thomas Keiko, 2008, Phys Occup Ther Pediatr, V28, P155, DOI 10.1080/01942630802031834
   Smeeth L, 2004, LANCET, V364, P963, DOI 10.1016/S0140-6736(04)17020-7
   Solish A, 2010, J APPL RES INTELLECT, V23, P226, DOI 10.1111/j.1468-3148.2009.00525.x
   South M, 2005, J AUTISM DEV DISORD, V35, P145, DOI 10.1007/s10803-005-1992-3
   Sparrow S., 2006, VINELAND ADAPTIVE BE, V2nd
   Stanley GC, 2007, J AUTISM DEV DISORD, V37, P1215, DOI 10.1007/s10803-006-0263-2
   Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x
   United Nations (UN) General Assembly, 1989, AD UN CONV RIGHTS CH
   Verte S, 2003, CHILD CARE HLTH DEV, V29, P193, DOI 10.1046/j.1365-2214.2003.00331.x
   Wagner M., 2002, OTHER 80 THEIR TIME
   Williamson S, 2008, AUTISM, V12, P391, DOI 10.1177/1362361308091652
   Wilson A., 1997, J INSTRUCTIONAL PSYC, V24, P76
   World Health Organisation, 2001, INT CLASS FUNCT DIS
NR 58
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 445
EP 457
DI 10.1007/s10803-012-1589-6
PG 13
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600015
PM 22752846
ER

PT J
AU Buon, M
   Dupoux, E
   Jacob, P
   Chaste, P
   Leboyer, M
   Zalla, T
AF Buon, Marine
   Dupoux, Emmanuel
   Jacob, Pierre
   Chaste, Pauline
   Leboyer, Marion
   Zalla, Tiziana
TI The Role of Causal and Intentional Judgments in Moral Reasoning in
   Individuals with High Functioning Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Moral judgment; Theory of mind; Causal reasoning; Autism
ID ASPERGER-SYNDROME; DIAGNOSTIC INTERVIEW; EXECUTIVE FUNCTIONS; SPECTRUM
   DISORDERS; CULPABLE CONTROL; NEURAL BASIS; FAUX PAS; RULE USE; MIND;
   CHILDREN
AB In the present study, we investigated the ability to assign moral responsibility and punishment in adults with high functioning autism or Asperger Syndrome (HFA/AS), using non-verbal cartoons depicting an aggression, an accidental harm or a mere coincidence. Participants were asked to evaluate the agent's causal and intentional roles, his responsibility and the punishment he deserves for his action. Adults with HFA/AS did not differ in judgments of suffering and causality from adults with typical development. However, subtle difficulties with judgments of intentional action and moral judgments were observed in participants with HFA/AS. These results are discussed in the light of emerging studies that deal with integrity of moral reasoning in individuals with autism spectrum disorders.
C1 [Buon, Marine; Dupoux, Emmanuel] Ecole Normale Super, Lab Sci Cognit & Psycholinguist, Ctr Natl Rech Sci, Dept Etudes Cognit, F-75231 Paris, France.
   [Buon, Marine; Jacob, Pierre; Zalla, Tiziana] Ecole Normale Super, Inst Jean Nicod, Ctr Natl Rech Sci, Dept Etudes Cognit, F-75231 Paris, France.
   [Chaste, Pauline; Leboyer, Marion; Zalla, Tiziana] Univ Paris Est Creteil, Henri Mondor Albert Chenevier Hosp, AP HP,IMRB,INSERM U955, Dept Psychiat,Fdn FondaMental,French Natl Sci Res, Creteil, France.
RP Buon, M (reprint author), Ecole Normale Super, Lab Sci Cognit & Psycholinguist, Ctr Natl Rech Sci, Dept Etudes Cognit, 24 Rue Lhomond, F-75231 Paris, France.
EM marinebuon@gmail.com; tiziana.zalla@ens.fr
CR ALICKE MD, 1992, J PERS SOC PSYCHOL, V63, P368, DOI 10.1037/0022-3514.63.3.368
   Alicke MD, 2000, PSYCHOL BULL, V126, P556, DOI 10.1037//0033-2909.126.4.556
   Alicke MD, 2008, PERS SOC PSYCHOL B, V34, P1371, DOI [10.1177/0146167208321594, 10.1177/1046167208321594]
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baird JA, 2004, NEW DIR CHILD ADOLES, V103, P37, DOI 10.1002/cd.96
   Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   BARONCOHEN S, 1989, J CHILD PSYCHOL PSYC, V30, P285, DOI 10.1111/j.1469-7610.1989.tb00241.x
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Bauminger N, 1999, J AUTISM DEV DISORD, V29, P81, DOI 10.1023/A:1025974701090
   Blair RJR, 1996, J AUTISM DEV DISORD, V26, P571
   BOWLER DM, 1992, J CHILD PSYCHOL PSYC, V33, P877, DOI 10.1111/j.1469-7610.1992.tb01962.x
   Buccino G, 2007, NEUROIMAGE, V36, pT119, DOI 10.1016/j.neuorimage.2007.03.036
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Channon S, 2011, J AUTISM DEV DISORD, V41, P1534, DOI 10.1007/s10803-011-1180-6
   Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781
   Cushman F, 2008, COGNITION, V108, P353, DOI 10.1016/j.cognition.2008.03.006
   CYR JJ, 1984, J CONSULT CLIN PSYCH, V52, P903, DOI 10.1037//0022-006X.52.5.903
   Gillberg C, 2001, AUTISM, V5, P57, DOI 10.1177/1362361301005001006
   Gillberg C, 2005, J AUTISM DEV DISORD, V35, P159, DOI 10.1007/s10803-005-1993-2
   Grant CM, 2005, AUTISM, V9, P317, DOI 10.1177/1362361305055418
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
   Hill EL, 2006, NEUROPSYCHOLOGIA, V44, P2822, DOI 10.1016/j.neuropsychologia.2006.06.007
   Jellema T, 2000, BRAIN COGNITION, V44, P280, DOI 10.1006/brcg.2000.1231
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Knobe J, 2005, TRENDS COGN SCI, V9, P357, DOI 10.1016/j.tics.2005.06.011
   Lagnado DA, 2008, COGNITION, V108, P754, DOI 10.1016/j.cognition.2008.06.009
   LESLIE AM, 1987, COGNITION, V27, P291, DOI 10.1016/S0010-0277(87)80014-8
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Moran JM, 2011, P NATL ACAD SCI USA, V108, P2688, DOI 10.1073/pnas.1011734108
   NELSONLEGALL SA, 1985, DEV PSYCHOL, V21, P332, DOI 10.1037//0012-1649.21.2.332
   Ozonoff S, 1997, AUTISM EXECUTIVE DIS, P179
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
   PIAGET J., 1965, MORAL JUDGEMENT CHIL
   Premack A., 1978, BEHAV BRAIN SCI, V4, P515
   Russell J., 1997, AUTISM EXECUTIVE DIS
   Saxe R, 2004, NEUROPSYCHOLOGIA, V42, P1435, DOI 10.1016/j.neuropsychologia.2004.04.015
   Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
   VanSpaendonck KPM, 1996, NEUROPSYCHOLOGIA, V34, P617, DOI 10.1016/0028-3932(95)00159-X
   Vivanti G, 2011, DEV PSYCHOL, V47, P841, DOI 10.1037/a0023105
   Volkmar F. R., 1990, DEV PSYCHOPATHOL, V2, P61, DOI 10.1017/S0954579400000596
   WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
   YIRMIYA N, 1992, CHILD DEV, V63, P150, DOI 10.1111/j.1467-8624.1992.tb03603.x
   Young L, 2009, NEUROPSYCHOLOGIA, V47, P2065, DOI 10.1016/j.neuropsychologia.2009.03.020
   Young L, 2007, P NATL ACAD SCI USA, V104, P8235, DOI 10.1073/pnas.0701408104
   Young L, 2010, P NATL ACAD SCI USA, V107, P6753, DOI 10.1073/pnas.0914826107
   Zalla T., 2011, REV PHILOS PSYCHOL, V2, P681, DOI DOI 10.1007/S13164-011-0048-1
   Zalla T, 2011, COGNITION, V121, P115, DOI 10.1016/j.cognition.2011.06.004
   Zalla T, 2009, J AUTISM DEV DISORD, V39, P373, DOI 10.1007/s10803-008-0634-y
   Zelazo PD, 1996, J CHILD PSYCHOL PSYC, V37, P479, DOI 10.1111/j.1469-7610.1996.tb01429.x
   Zelazo PD, 2002, INFANT CHILD DEV, V11, P171, DOI 10.1002/icd.304
NR 56
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 458
EP 470
DI 10.1007/s10803-012-1588-7
PG 13
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600016
PM 22760338
ER

PT J
AU Reed, P
   Osborne, LA
AF Reed, Phil
   Osborne, Lisa A.
TI The Role of Parenting Stress in Discrepancies Between Parent and Teacher
   Ratings of Behavior Problems in Young Children with Autism Spectrum
   Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Behavior problems; Informant rating;
   Discrepancies; Assessment environment; Parent stress
ID DISRUPTIVE BEHAVIOR; EMOTIONAL-PROBLEMS; AGREEMENT; QUESTIONNAIRE;
   ADOLESCENTS; SYMPTOMS; INTERVENTIONS; RESOURCES; MOTHERS; ADHD
AB The study assessed whether teacher and parent ratings of child behavior problems were similar for children with autism spectrum disorders. Two informants rated child behaviors in the same home environment, and the degree to which parenting stress impacted the similarity of the ratings was assessed. Overall behavior problem ratings did not differ between groups, but there was poor correspondence between the ratings for individual children, stress did not impact markedly on the discrepancies. Parent-teacher discrepancies in behavior ratings cannot be attributed entirely to differences in the assessment-environment, and there was little evidence of widespread impacts of parenting stress on these discrepant ratings. It was suggested that attention is needed in terms of the teacher characteristics when explaining such results.
C1 [Reed, Phil] Swansea Univ, Dept Psychol, Swansea SA2 8PP, W Glam, Wales.
   [Osborne, Lisa A.] Swansea Univ, Long Term & Chron Condit Ctr, Swansea SA2 8PP, W Glam, Wales.
RP Reed, P (reprint author), Swansea Univ, Dept Psychol, Singleton Pk, Swansea SA2 8PP, W Glam, Wales.
EM p.reed@swan.ac.uk
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
   ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
   Altman D, 2006, BRIT MED J, V332, P332, DOI DOI 10.1136/BMJ.332.7549.1080
   Antrop I, 2002, J PSYCHOPATHOL BEHAV, V24, P67, DOI 10.1023/A:1014057325752
   Boyle MH, 1997, J CHILD PSYCHOL PSYC, V38, P981, DOI 10.1111/j.1469-7610.1997.tb01615.x
   Conners CK, 1997, CONNERS PARENT RATIN
   De Los Reyes A, 2005, PSYCHOL BULL, V131, P483, DOI DOI 10.1037/0033-2909.131.4.483
   De Los Reyes A, 2009, J ABNORM CHILD PSYCH, V37, P637, DOI 10.1007/s10802-009-9307-3
   De Los Reyes M. S., 2006, J CHILD FAM STUD, V15, P643
   DYSON L, 1989, AM J MENT RETARD, V94, P292
   Einfeld S. L., 1995, MANUAL DEV BEHAV CHE
   FONG PL, 1991, J CONSULT CLIN PSYCH, V59, P471, DOI 10.1037/0022-006X.59.3.471
   Frederickson N., 2004, ED PSYCHOL, V24, P263, DOI 10.1080/0144341042000211652
   FRIEDRICH WN, 1983, AM J MENT DEF, V88, P41
   Gilliam J. E., 1995, GILLIAM AUTISM RATIN
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Grills AE, 2003, J AM ACAD CHILD PSY, V42, P30, DOI 10.1097/01.CHI.0000024899.60748.EE
   Hastings RP, 2001, J AUTISM DEV DISORD, V31, P327, DOI 10.1023/A:1010799320795
   Honey E, 2005, AUTISM, V9, P246, DOI 10.1177/1362361305053256
   Howell D. C., 1997, STAT METHODS PSYCHOL
   Johnson SA, 2009, J AUTISM DEV DISORD, V39, P1706, DOI 10.1007/s10803-009-0809-1
   Kalyva E, 2010, J AUTISM DEV DISORD, V40, P1202, DOI 10.1007/s10803-010-0978-y
   Kanne SM, 2009, J AUTISM DEV DISORD, V39, P856, DOI 10.1007/s10803-009-0694-7
   KOLKO DJ, 1993, J CHILD PSYCHOL PSYC, V34, P991, DOI 10.1111/j.1469-7610.1993.tb01103.x
   Koning C, 2001, AUTISM, V5, P23, DOI 10.1177/1362361301005001003
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Osborne LA, 2009, FAM ISS 21ST CENTURY, P259
   Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
   Papageorgiou V, 2008, EUR J PSYCHIAT, V22, P200, DOI http://dx.doi.org/10.4321/s0213-61632008000400003
   Reed P, 2010, AUTISM, V14, P67, DOI 10.1177/1362361309340030
   Reed P, 2007, EXCEPT CHILDREN, V73, P417
   Rettew DC, 2011, J CHILD ADOL PSYCHOP, V21, P389, DOI 10.1089/cap.2010.0153
   RICHTERS JE, 1992, PSYCHOL BULL, V112, P485, DOI 10.1037/0033-2909.112.3.485
   Schopler E, 1990, PSYCHOEDUCATIONAL PR
   STANGER C, 1993, J CLIN CHILD PSYCHOL, V22, P107, DOI 10.1207/s15374424jccp2201_11
   Treutler CM, 2003, J ABNORM CHILD PSYCH, V31, P13, DOI 10.1023/A:1021765114434
   VERHULST FC, 1989, J CHILD PSYCHOL PSYC, V30, P123, DOI 10.1111/j.1469-7610.1989.tb00772.x
   Youngstrom E, 2000, J CONSULT CLIN PSYCH, V68, P1038, DOI 10.1037/0022-006X.68.6.1038
NR 38
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 471
EP 477
DI 10.1007/s10803-012-1594-9
PG 7
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600017
PM 22767139
ER

PT J
AU Riby, DM
   Janes, E
   Rodgers, J
AF Riby, Deborah M.
   Janes, Emily
   Rodgers, Jacqui
TI Brief Report: Exploring the Relationship Between Sensory Processing and
   Repetitive Behaviours in Williams Syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Williams syndrome; Sensory processing; Repetitive behaviour
ID AUTISM SPECTRUM DISORDERS; CHILDREN; PHENOTYPE; ADULTS
AB This study explored the relationship between sensory processing abnormalities and repetitive behaviours in children with Williams Syndrome (WS; n = 21). This is a novel investigation bringing together two clinical phenomena for the first time in this neuro-developmental disorder. Parents completed the Sensory Profile (Short Form; Dunn in The sensory profile manual. San Antonio: The Psychological Corporation, 1999) and the Repetitive Behaviour Questionnaire (Turner 1995). A significant correlation was evident between the total scores on each of these measures; suggesting that children with WS who exhibit increased sensory processing abnormalities also display a higher number of repetitive behaviours. Further exploratory analyses of subscales of the measures indicated potentially important relationships that suggest a role for arousal regulation in the relationship between sensory processing abnormalities and repetitive behaviours in WS.
C1 [Riby, Deborah M.; Janes, Emily] Newcastle Univ, Sch Psychol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
   [Janes, Emily; Rodgers, Jacqui] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
RP Janes, E (reprint author), Northumberland Tyne & Wear NHS Trust, Community Team Learning Disabil, Benton House,136 Sandyford Rd, Newcastle Upon Tyne NE2 1QE, Tyne & Wear, England.
EM e.v.janes@ncl.ac.uk
CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0
   Chen YH, 2009, J AUTISM DEV DISORD, V39, P635, DOI 10.1007/s10803-008-0663-6
   Davies M, 1998, BRIT J PSYCHIAT, V172, P273, DOI 10.1192/bjp.172.3.273
   Doherty-Sneddon G., 2009, COGNITIVE NEUROPSYCH, V14, P1
   Donnai D, 2000, AM J MED GENET, V97, P164, DOI 10.1002/1096-8628(200022)97:2<164::AID-AJMG8>3.0.CO;2-F
   Dunn W., 1999, SENSORY PROFILE MANU
   Dunn W., 2005, TECHNICAL REPORT SEN
   Gabriels R. L., 2005, INT M AUT RES
   Gabriels RL, 2008, RES AUTISM SPECT DIS, V2, P660, DOI 10.1016/j.rasd.2008.02.002
   Haas BW, 2009, J NEUROSCI, V29, P1132, DOI 10.1523/JNEUROSCI.5324-08.2009
   Honey E, 2012, RES AUTISM SPECT DIS, V6, P355, DOI 10.1016/j.rasd.2011.06.009
   John A. E., 2010, AM J MED GENET C, V154C, P229
   Joosten AV, 2009, J AUTISM DEV DISORD, V39, P521, DOI 10.1007/s10803-008-0654-7
   Leekam SR, 2011, PSYCHOL BULL, V137, P562, DOI 10.1037/a0023341
   Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021
   Martens MA, 2008, J CHILD PSYCHOL PSYC, V49, P576, DOI 10.1111/j.1469-7610.2008.01887.x
   McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
   Mervis CB, 2000, BRAIN COGNITION, V44, P604, DOI 10.1006/brcg.2000.1232
   Morris CA, 1999, HANDBOOK OF NEURODEVELOPMENTAL AND GENETIC DISORDERS IN CHILDREN, P555
   Plesa Skwerer D, 2009, Soc Cogn Affect Neurosci, V4, P93, DOI 10.1093/scan/nsn041
   Searcy YM, 2004, AM J MENT RETARD, V109, P231, DOI 10.1352/0895-8017(2004)109<231:TRBAAI>2.0.CO;2
   Semel E., 2003, UNDERSTANDING WILLIA
   Stromme P, 2002, J CHILD NEUROL, V17, P269, DOI 10.1177/088307380201700406
   Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
   Turner M. A., 1995, THESIS U CAMBRIDGE U
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
NR 27
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 478
EP 482
DI 10.1007/s10803-012-1557-1
PG 5
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600018
PM 22677930
ER

PT J
AU Brundage, SB
   Whelan, CJ
   Burgess, CM
AF Brundage, Shelley B.
   Whelan, Cory J.
   Burgess, Cathleen M.
TI Brief Report: Treating Stuttering in an Adult with Autism Spectrum
   Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Stuttering; Autism; Disfluency; Treatment; Single subject design
ID FRAGILE-X SYNDROME; CHILDREN; SPEECH
AB Stuttering and autism can co-occur and when they do it presents a significant communication challenge. This study examined the effectiveness of a modified version of the fluency rules program (FRP; Runyan and Runyan, Stuttering and related disorders of fluency, in 2007) to reduce stuttering frequency in a man with autism spectrum disorder (ASD). The participant's percentage of stuttered words (%SW) was calculated during conversational interactions with multiple conversation partners both within and outside of the clinic treatment sessions. Visual inspection methods revealed a reduction in %SW from an average of 14.5 %SW during baseline to 2.07 %SW during the withdrawal phase. The mean baseline reduction in %SW from baseline to the second treatment phase was 91.8 %. The FRP holds promise for reducing %SW in persons with ASD who stutter.
C1 [Brundage, Shelley B.] George Washington Univ, Dept Speech & Hearing Sci, Washington, DC 20052 USA.
   [Burgess, Cathleen M.] Katherine Thomas Sch, Rockville, MD USA.
RP Brundage, SB (reprint author), George Washington Univ, Dept Speech & Hearing Sci, 2115 G St NW,Suite 201, Washington, DC 20052 USA.
EM brundage@gwu.edu
CR BERNSTEINRATNER N, 1996, CLIN LINGUISTICS PHO, V0010
   Bloodstein O., 2008, HDB STUTTERING
   Bothe AK, 2006, AM J SPEECH-LANG PAT, V15, P321, DOI 10.1044/1058-0360(2006/031)
   Campbell JM, 2004, BEHAV MODIF, V28, P234, DOI 10.1177/0145445503259264
   Conture E. G., 1999, STUTTERING RES PRACT
   Ferraioli SJ, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P171, DOI 10.1007/978-1-4419-6975-0_6
   FERRIER LJ, 1991, DEV MED CHILD NEUROL, V33, P776
   Garcia Winner M., 2005, THINK SOCIAL
   GOLDMANEISLER F, 1961, LANG SPEECH, V4, P220
   Guitar B, 2006, STUTTERING INTEGRATE
   Hietala A., 2005, AM SPEECH LANG HEAR
   Kazdin A., 2011, SINGLE CASE RES DESI
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   MACLAY H, 1959, WORD, V15, P19
   MacWhinney B, 2012, CHILDES PROJECT TOOL
   Manning W. H., 2010, CLIN DECISION MAKING
   Olive M. L., 2005, ED PSYCHOL, V25, P313, DOI DOI 10.1080/0144341042000301238
   PAUL R, 1987, J AUTISM DEV DISORD, V17, P457, DOI 10.1007/BF01486963
   Plexico L. W., 2010, PERSPECTIVES FLUENCY, V20, P42
   PRIZANT BM, 1981, J SPEECH HEAR DISORD, V46, P241
   Riley Glyndon D., 2009, STUTTERING SEVERITY
   Runyan C., 2007, STUTTERING RELATED D, P100
   Runyan C., 1986, LANG SPEECH HEAR SER, V17, P276
   RYAN BP, 1995, J SPEECH HEAR RES, V38, P61
   Scaler-Scott K., 2007, DISFLUENCY AUTISM SP
   Semel E., 2003, CLIN EVALUATION LANG, V4th
   Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087)
   Sisskin V, 2006, PERSPECTIVES FLUENCY, V16, P12
   Sisskin V., 2007, SPEECH DISFLUENCY AU
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Stribling P, 2007, INT J LANG COMM DIS, V42, P427, DOI 10.1080/13682820601183659
   Tantam D, 2001, ASPERGER SYNDROME, P367
   Van Borsel J, 2007, J FLUENCY DISORD, V32, P279, DOI 10.1016/j.jfludis.2007.07.002
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   Whitehouse AJO, 2009, INT J LANG COMM DIS, V44, P511, DOI 10.1080/13682820802708098
   Yaruss J. S., 1997, CONT ISSUES COMMUNIC, V24, P33
NR 36
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 483
EP 489
DI 10.1007/s10803-012-1596-7
PG 7
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600019
PM 22790383
ER

PT J
AU Kliemann, K
AF Kliemann, Karen
TI Commentary on "Long-term Cognitive and Behavioral Therapies, Combined
   with Augmentative Communication are Related to Uncinate Fasciculus
   Integrity in Autism" Pardini, M., Elia, M., Garaci, R., Guida, S.,
   Coniglione, F., Krueger, F., Benassi, F., & Gialloreti, E. (2011)
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Letter
C1 [Kliemann, Karen] Univ N Texas, Denton, TX 76203 USA.
RP Kliemann, K (reprint author), 6604 Kingsferry Court, Arlington, TX 76016 USA.
EM karinaruth@sbcglobal.net
CR Reichow B, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P1, DOI 10.1007/978-1-4419-6975-0
   Reichow B, 2008, J AUTISM DEV DISORD, V38, P1311, DOI 10.1007/s10803-007-0517-7
NR 2
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 491
EP 492
DI 10.1007/s10803-012-1602-0
PG 2
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600021
PM 22790428
ER

PT J
AU Gomez-Duran, EL
   Martin-Fumado, C
   Litvan, L
   Campillo, M
   Taylor, PJ
AF Gomez-Duran, Esperanza L.
   Martin-Fumado, Carles
   Litvan, Lia
   Campillo, Maite
   Taylor, Pamela J.
TI Matricide by Failure to Act in Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Letter
ID SPECTRUM DISORDERS
C1 [Gomez-Duran, Esperanza L.] Fdn Sociosanitaria Barcelona, Hosp Duran & Reynals, Lhospitalet De Llobregat 08908, Spain.
   [Gomez-Duran, Esperanza L.] Col Legi Oficial Metges Barcelona, Serv Responsabilitat Profess, Barcelona, Spain.
   [Gomez-Duran, Esperanza L.] Univ Internac Catalunya, Barcelona, Spain.
   [Martin-Fumado, Carles] Catalan Inst Legal Med, Barcelona, Spain.
   [Litvan, Lia; Campillo, Maite] CAEM, Barcelona, Spain.
   [Taylor, Pamela J.] Cardiff Univ, Inst Psychol Med & Clin Neurosci, Sch Med, Cardiff CF10 3AX, S Glam, Wales.
RP Gomez-Duran, EL (reprint author), Fdn Sociosanitaria Barcelona, Hosp Duran & Reynals, Av Gran Via LHospitalet, Lhospitalet De Llobregat 08908, Spain.
EM elgomezduran@gmail.com
CR Bastiaansen J. A., 2010, J AUTISM DEV DISORD, V41, P1256
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   Horton A. M., 2003, HDB FORENSIC NEUROPS
   Katz N, 2006, ISRAEL J PSYCHIAT, V43, P166
   Cashin Andrew, 2009, J Forensic Nurs, V5, P70, DOI 10.1111/j.1939-3938.2009.01037.x
   Noland RM, 2004, J AUTISM DEV DISORD, V34, P265, DOI 10.1023/B:JADD.0000029549.84385.44
NR 6
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 495
EP 497
DI 10.1007/s10803-012-1590-0
PG 3
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600023
PM 22790425
ER

PT J
AU Tomeny, T
   Barry, T
AF Tomeny, Theodore S.
   Barry, Tammy D.
TI Social Skills Training for Children with Asperger Syndrome and
   High-Functioning Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Book Review
C1 [Tomeny, Theodore S.; Barry, Tammy D.] Univ So Mississippi, Hattiesburg, MS 39406 USA.
RP Barry, T (reprint author), Univ So Mississippi, 118 Coll Dr 5025, Hattiesburg, MS 39406 USA.
EM tammy.barry@usm.edu
CR WHITE SW, 2011, SOCIAL SKILLS TRAINI
NR 1
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 498
EP 499
DI 10.1007/s10803-012-1610-0
PG 2
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600024
ER

PT J
AU Smith, J
AF Smith, Jeffrey Brian
TI Success Strategies for Teaching Kids with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Book Review
C1 [Smith, Jeffrey Brian] Univ Memphis, Leadership Dept, Memphis, TN 38016 USA.
RP Smith, J (reprint author), Univ Memphis, Leadership Dept, 1437 Dexter Lake Dr,Apt 301, Memphis, TN 38016 USA.
EM BrianSmithBCBA@gmail.com
CR Ascroft W., 2010, SUCCESS STRATEGIES T
   ASHCROFT W, 2010, SUCCESS STRATEGIES T
   Meyers S. M., 2007, PEDIATRICS, V120, P1162
   Napolitano DA, 2010, J APPL BEHAV ANAL, V43, P265, DOI 10.1901/jaba.2010.43-265
   New York State Department of Health Early Intervention Program, 1999, NYSDH PUBL, V4215
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Sancho K., 2010, EDUC TREAT CHILD, V33, P421, DOI DOI 10.1353/ETC.0.0097
NR 7
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2013
VL 43
IS 2
BP 500
EP 501
DI 10.1007/s10803-012-1641-6
PG 2
WC Psychology, Developmental
SC Psychology
GA 074HN
UT WOS:000313803600025
ER

PT J
AU Ozonoff, S
AF Ozonoff, Sally
TI Editorial: Recovery from autism spectrum disorder (ASD) and the science
   of hope
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Editorial Material
ID CHILDREN
CR Broderick AA, 2009, INTELLECT DEV DISAB, V47, P263, DOI 10.1352/1934-9556-47.4.263
   Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
NR 3
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD FEB
PY 2013
VL 54
IS 2
BP 113
EP 114
DI 10.1111/jcpp.12045
PG 2
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 075FH
UT WOS:000313868700001
PM 23320805
ER

PT J
AU Rhee, SH
   Friedman, NP
   Boeldt, DL
   Corley, RP
   Hewitt, JK
   Knafo, A
   Lahey, BB
   Robinson, J
   Van Hulle, CA
   Waldman, ID
   Young, SE
   Zahn-Waxler, C
AF Rhee, Soo Hyun
   Friedman, Naomi P.
   Boeldt, Debra L.
   Corley, Robin P.
   Hewitt, John. K.
   Knafo, Ariel
   Lahey, Benjamin B.
   Robinson, JoAnn
   Van Hulle, Carol A.
   Waldman, Irwin D.
   Young, Susan E.
   Zahn-Waxler, Carolyn
TI Early concern and disregard for others as predictors of antisocial
   behavior
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Antisocial behavior; empathy; concern for others; disregard for others
ID AUTISM SPECTRUM DISORDER; UNEMOTIONAL TRAITS; FIT INDEXES; EMPATHY;
   CHILDREN; AGGRESSION; DELINQUENCY; ADOLESCENCE; STABILITY; DISTRESS
AB Background: Prediction of antisocial behavior is important, given its adverse impact on both the individuals engaging in antisocial behavior and society. Additional research identifying early predictors of future antisocial behavior, or antisocial propensity, is needed. The present study tested the hypothesis that both concern for others and active disregard for others in distress in toddlers and young children predict antisocial behavior during middle childhood and adolescence. Methods: A representative sample of same-sex twins (N = 956) recruited in Colorado was examined. Mother-rated and researcher-observed concern and disregard for others assessed at age 1436 months were examined as predictors of parent- (age 412), teacher- (age 712), and self-reported (age 17) antisocial behavior. Results: Observed disregard for others predicted antisocial behavior assessed by three different informants (parents, teachers, and self), including antisocial behavior assessed 14 years later. It also predicted a higher order antisocial behavior factor (beta = .58, p < .01) after controlling for observed concern for others. Mother-rated disregard for others predicted parent-reported antisocial behavior. Contrary to predictions, neither mother-rated nor observed concern for others inversely predicted antisocial behavior. Results of twin analyses suggested that the covariation between observed disregard for others and antisocial behavior was due to shared environmental influences. Conclusions: Disregard for others in toddlerhood/early childhood is a strong predictor of antisocial behavior in middle childhood and adolescence. The results suggest the potential need for early assessment of disregard for others and the development of potential interventions.
C1 [Rhee, Soo Hyun; Friedman, Naomi P.; Boeldt, Debra L.; Corley, Robin P.; Hewitt, John. K.; Young, Susan E.] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA.
   [Rhee, Soo Hyun; Boeldt, Debra L.; Hewitt, John. K.] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA.
   [Knafo, Ariel] Hebrew Univ Jerusalem, Dept Psychol, IL-91905 Jerusalem, Israel.
   [Lahey, Benjamin B.] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA.
   [Robinson, JoAnn] Univ Connecticut, Dept Human Dev & Family Studies, Storrs, CT USA.
   [Van Hulle, Carol A.; Zahn-Waxler, Carolyn] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA.
   [Waldman, Irwin D.] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA.
RP Rhee, SH (reprint author), Univ Colorado, Dept Psychol & Neurosci, Campus Box 345, Boulder, CO 80309 USA.
EM soo.rhee@colorado.edu
FU MacArthur Foundation; Fetzer Foundation; National Institutes of Health
   [MH016880, HD010333, HD050346, DA011015]
FX This study was supported by the MacArthur Foundation, the Fetzer
   Foundation, and National Institutes of Health grants MH016880, HD010333,
   HD050346, and DA011015. We thank the Longitudinal Twin Study
   investigators, Corinne Wright, Sally Ann Rhea, Akira Miyake, and the LTS
   participants and research assistants. Preliminary results of this study
   were presented at the annual meeting of the Society for Research in
   Child Development on April 2, 2009 in Denver, CO and the annual meeting
   of the Behavior Genetics Association on June 3, 2010 in Seoul, S. Korea.
CR Achenbach T. M., 1991, MANUAL TEACHERS REPO
   Achenbach TM, 1991, MANUAL CHILD BEHAV C
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Asparouhov T., 2010, TECHNICAL REPORT
   van Beijsterveldt CEM, 2003, BEHAV GENET, V33, P591, DOI 10.1023/A:1025735002864
   BENTLER PM, 1990, PSYCHOL BULL, V107, P238, DOI 10.1037//0033-2909.107.2.238
   Browne MW, 1993, TESTING STRUCTURAL E, V154, P136, DOI DOI 10.1177/0049124192021002005
   Cote SM, 2006, J ABNORM CHILD PSYCH, V34, P71, DOI 10.1007/s10802-005-9001-z
   Dadds MR, 2003, CLIN CHILD FAM PSYCH, V6, P69, DOI 10.1023/A:1023762009877
   Damon W., 1998, HDB CHILD PSYCHOL, V3, P701
   Decety J., 2000, BIOL PSYCHOL, V80, P203
   Decety J, 2008, DEV PSYCHOPATHOL, V20, P1053, DOI 10.1017/S0954579408000503
   Eisenberg N, 2005, NEBR SYM MOTIV, V51, P73
   Emde R. N., 2001, INFANCY EARLY CHILDH
   FESHBACH ND, 1969, DEV PSYCHOL, V1, P102, DOI 10.1037/h0027016
   Frick Paul J, 2006, Curr Psychiatry Rep, V8, P59, DOI 10.1007/s11920-006-0082-3
   Frick PJ, 2005, J ABNORM CHILD PSYCH, V33, P471, DOI 10.1007/s10648-005-5728-9
   Harpur T. J., 1989, PSYCHOL ASSESSMENT J, V1, P6, DOI DOI 10.1037/1040-3590.1.1.6
   Hastings P., 2007, HDB SOCIALIZATION TH, P636
   Hastings PD, 2000, DEV PSYCHOL, V36, P531, DOI 10.1037//0012-1649.36.5.531
   Hu LT, 1998, PSYCHOL METHODS, V3, P424, DOI 10.1037//1082-989X.3.4.424
   Janssens J. M. A. M., 1992, CHILD REARING INFLUE, P57
   Jones AP, 2010, J CHILD PSYCHOL PSYC, V51, P1188, DOI 10.1111/j.1469-7610.2010.02280.x
   KLIMESDOUGAN B, 1990, DEV PSYCHOL, V26, P599, DOI 10.1037//0012-1649.26.4.599
   MILLER PA, 1988, PSYCHOL BULL, V103, P324, DOI 10.1037/0033-2909.103.3.324
   Moran P, 2008, BRIT J PSYCHIAT, V192, P65, DOI 10.1192/bjp.bp.106.034876
   Murphy L. B., 1937, SOCIAL BEHAV CHILD P
   Muthen L. K., 1998, MPLUS USERS GUIDE
   Rhea SA, 2006, TWIN RES HUM GENET, V9, P941, DOI 10.1375/183242706779462895
   Robbers SCC, 2010, TWIN RES HUM GENET, V13, P79, DOI 10.1375/twin.13.1.79
   Rogers J, 2006, PSYCHOL MED, V36, P1789, DOI 10.1017/S0033291706008853
   Shaffer D, 2000, J AM ACAD CHILD PSY, V39, P28, DOI 10.1097/00004583-200001000-00014
   Shirtcliff EA, 2009, BEHAV SCI LAW, V27, P137, DOI 10.1002/bsl.862
   Sterzer P, 2007, NEUROIMAGE, V37, P335, DOI 10.1016/j.neuroimage.2007.04.043
   Van Hulle CA, 2007, J ABNORM PSYCHOL, V116, P236, DOI 10.1037/0021-843X.116.2.236
   Waldman I. D., 2006, HDB PSYCHOPATHY, P205
   ZAHNWAXLER C, 1992, DEV PSYCHOL, V28, P1038, DOI 10.1037//0012-1649.28.6.1038
   ZAHNWAXLER C, 1979, CHILD DEV, V50, P319, DOI 10.1111/j.1467-8624.1979.tb04112.x
   ZAHNWAXLER C, 1992, DEV PSYCHOL, V28, P126, DOI 10.1037/0012-1649.28.1.126
NR 39
TC 5
Z9 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD FEB
PY 2013
VL 54
IS 2
BP 157
EP 166
DI 10.1111/j.1469-7610.2012.02574.x
PG 10
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 075FH
UT WOS:000313868700005
PM 23320806
ER

PT J
AU Corsello, CM
   Akshoomoff, N
   Stahmer, AC
AF Corsello, Christina M.
   Akshoomoff, Natacha
   Stahmer, Aubyn C.
TI Diagnosis of autism spectrum disorders in 2-year-olds: a study of
   community practice
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism; diagnosis; services research
ID MODIFIED CHECKLIST; ADI-R; TODDLERS; CHILDREN; AGE; IDENTIFICATION;
   AGREEMENT; ADOS
AB Background: Longitudinal research studies have demonstrated that experienced clinicians using standardized assessment measures can make a reliable diagnosis of autism spectrum disorders (ASDs) in children under age 3. Limited data are available regarding the sensitivity and specificity of these measures in community settings. The aims of this study were to determine how well a standardized diagnostic observational measure (Autism Diagnostic Observation Schedule ADOS) functions alone, and with a brief parent measure within a community setting when administered by community clinicians. Methods: Clinical records for 138 children between the ages of 24 and 36 months of age who were evaluated for possible ASD or social/language concerns at a hospital-based developmental evaluation clinic were examined. Evaluations were conducted by community-based clinical psychologists. Classification results obtained from standardized diagnostic measures were compared with case reviewer diagnosis, by reviewers blind to scores on diagnostic measures, using The Records-based Methodology for ASD Case Definition that was developed by the Metropolitan Atlanta Developmental Disabilities Surveillance Program. Results: When compared with case review diagnosis, the ADOS demonstrated strong sensitivity and specificity for both Autism versus Not Autism and ASD versus Nonspectrum (NS) diagnoses in this young sample. The Social Communication Questionnaire (SCQ), using the lower cutoff of =12, had adequate sensitivity when differentiating Autism from Not Autism, but weak sensitivity when differentiating ASD from NS, missing about 80% of the children with pervasive developmental disorder not otherwise specified. Using either the Modified Checklist for Autism in Toddlers or the SCQ in combination with the ADOS did not result in improved specificity over the ADOS alone and led to a drop in sensitivity when differentiating ASD from NS disorders. Conclusions: These results demonstrate that following best practice guidelines, the ADOS can be successfully incorporated into clinical practice with relatively good sensitivity and specificity, and worked well with a referred sample of 2-year-olds. A parent questionnaire did not lead to any improvement in diagnostic classification above the ADOS used in isolation.
C1 [Corsello, Christina M.; Akshoomoff, Natacha; Stahmer, Aubyn C.] Rady Childrens Hosp San Diego, San Diego, CA USA.
   [Akshoomoff, Natacha] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
RP Akshoomoff, N (reprint author), Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr,0115, La Jolla, CA 92093 USA.
EM nakshoomoff@ucsd.edu
FU National Institutes of Health [K23MH071796, K01MH065325]
FX This study was supported by grants from the National Institutes of
   Health: K23MH071796 (to N.A.) and K01MH065325 (to A. C. S.). We also
   thank our research assistants, Rebecca Pinon Ruiz, Jasper Estabillo, and
   Therese Gadomski.
CR Bayley N., 2005, BAYLEY SCALES INFANT, Vthird
   Bayley N, 1993, BAYLEY SCALES INFANT
   California Department of Developmental Services, 2002, AUT SPECTR DIS BEST
   CDC (Cent. Dis. Control Prev.), 2007, MMWR SURVEILL SUMM, V56, P12
   Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
   Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
   Filipek PA, 2000, NEUROLOGY, V55, P468
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
   Lord C., 2001, AUTISM DIAGNOSTIC OB
   Mandell D. S., 2007, J AUTISM DEV DISORD, V116, P1480
   Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
   Mazefsky CA, 2006, AUTISM, V10, P533, DOI 10.1177/136236130606850S
   Molloy CA, 2011, AUTISM, V15, P143, DOI 10.1177/1362361310379241
   Mullen E, 1995, MULLEN SCALES EARLY
   National Research Council, 2001, ED CHILDR AUT
   Pandey J, 2008, AUTISM, V12, P513, DOI 10.1177/1362361308094503
   Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
   Robins DL, 2006, J DEV BEHAV PEDIATR, V27, pS111, DOI 10.1097/00004703-200604002-00009
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Rutter M., 2003, ADI R AUTISM DIAGNOS
   Rutter M., 2003, SOCIAL COMMUNICATION
   Shattuck PT, 2009, J AM ACAD CHILD PSY, V48, P474, DOI 10.1097/CHI.0b013e31819b3848
   Sparrow S. S., 2005, VINELAND ADAPTIVE BE
   Turner LM, 2007, J CHILD PSYCHOL PSYC, V48, P793, DOI 10.1111/j.1469-7610.2007.01744.x
   Ventola PE, 2006, J AUTISM DEV DISORD, V36, P839, DOI 10.1007/s10803-006-0128-8
   Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
   Wiggins LD, 2008, J AUTISM DEV DISORD, V38, P972, DOI 10.1007/s10803-007-0456-3
NR 31
TC 5
Z9 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD FEB
PY 2013
VL 54
IS 2
BP 178
EP 185
DI 10.1111/j.1469-7610.2012.02607.x
PG 8
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 075FH
UT WOS:000313868700008
PM 22905987
ER

PT J
AU Simonoff, E
   Jones, CRG
   Baird, G
   Pickles, A
   Happe, F
   Charman, T
AF Simonoff, Emily
   Jones, Catherine R. G.
   Baird, Gillian
   Pickles, Andrew
   Happe, Francesca
   Charman, Tony
TI The persistence and stability of psychiatric problems in adolescents
   with autism spectrum disorders
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorder; psychopathology; psychiatric disorders;
   emotional and behavioural problems SNAP; longitudinal
ID DIFFICULTIES QUESTIONNAIRE SDQ; COMMUNITY SAMPLE; INTELLECTUAL
   DISABILITY; EMOTIONAL-PROBLEMS; CHILDREN; STRENGTHS; HEALTH;
   ASSOCIATIONS; COMORBIDITY; PREVALENCE
AB Background: Psychiatric problems are common in autism spectrum disorders (ASDs), but the reasons are poorly understood. We use a longitudinal population-representative cohort to examine for the first time the persistence of psychiatric problems and to identify risk factors for their occurrence and stability. Methods: Eighty-one 16-year olds (75 male, six female), initially seen at 12 years, were re-assessed using the parent-report Strengths and Difficulties Questionnaire (SDQ). Child, family and contextual characteristics from age 12 were tested as risk factors for psychopathology. Results: Prevalence rates varied depending on whether general population or ASD-specific SDQ cut-offs were used. While the former suggested a decrease in psychiatric problems over time, the ASD-specific cut-offs showed no significant differences. With the exception of ADHD, the ASD-specific cut-offs identified a smaller proportion of individuals as affected than did the general population cut-offs. There was longitudinal domain specificity, with parent correlations ranging from 0.50 to 0.58 and teacher SDQ reports at age 12 correlating 0.330.53 with parent reports at 16 years. In examining the role of risk factors, lower IQ and adaptive functioning predicted higher hyperactivity and total difficulties scores. Greater emotional problems at 16 were predicted by poorer maternal mental health, family-based deprivation and lower social class. Improvement from 12 to 16 years in conduct problems was predicted by greater neighbourhood deprivation and special school attendance. Conclusions: This is the first longitudinal study of other psychiatric symptoms in ASD. Additional psychiatric problems in ASD are persistent and domain-specific from childhood to adolescence. The finding that age-related reduction in SDQ symptoms does not apply when ASD-specific cut-offs are used requires further evaluation using diagnostic measures. Only a few of the expected risk factor-psychopathology predictions expected from general population studies were found, raising the possibility that the causes of psychopathology in ASD differ from those in the general population.
C1 [Simonoff, Emily] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London SE5 8AF, England.
   [Simonoff, Emily; Pickles, Andrew] NIHR Biomed Res Ctr Mental Hlth, London SE5 8AF, England.
   [Jones, Catherine R. G.] Univ Essex, Dept Psychol, Colchester CO4 3SQ, Essex, England.
   [Baird, Gillian] Guys & St Thomas NHS Fdn Trust, London, England.
   [Pickles, Andrew] Kings Coll London, Dept Biostat, Inst Psychiat, London SE5 8AF, England.
   [Happe, Francesca] Kings Coll London, MRC SGDP Res Ctr, Inst Psychiat, London SE5 8AF, England.
   [Charman, Tony] Univ London, Inst Educ, Ctr Res Autism & Educ, London WC1N 1AZ, England.
RP Simonoff, E (reprint author), Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, Crespigny Pk, London SE5 8AF, England.
EM emily.simonoff@kcl.ac.uk
RI Jones, Catherine/E-4956-2013; Charman, Tony/A-2085-2014; Pickles,
   Andrew/A-9625-2011
OI Charman, Tony/0000-0003-1993-6549; Pickles, Andrew/0000-0003-1283-0346
FU Medical Research Council [G0400065]; Social Communication Questionnaire
FX The study was funded by the Medical Research Council (G0400065). We
   thank Robert Goodman (King's College London) for providing age-specific
   unpublished UK norms for the Strengths and Difficulties Questionnaire.
   A. P. receives royalties from the Social Communication Questionnaire. F.
   H. received a one-off consultancy payment from Novartis in March 2011.
   There are no other conflicts of interest, financial or otherwise.
CR Abidin RR, 1995, PARENTING STRESS IND
   Angold A, 2000, J AM ACAD CHILD PSY, V39, P39, DOI 10.1097/00004583-200001000-00015
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Bauminger N, 2010, AUTISM RES, V3, P101, DOI 10.1002/aur.131
   Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004
   Bourdon KH, 2005, J AM ACAD CHILD PSY, V44, P557, DOI 10.1097/01.chi.0000159157.57075.c8
   Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075
   Emerson E, 2003, J INTELL DISABIL RES, V47, P51, DOI 10.1046/j.1365-2788.2003.00464.x
   Foley DL, 2001, J CHILD PSYCHOL PSYC, V42, P381
   Ford T, 2004, SOC PSYCH PSYCH EPID, V39, P487, DOI 10.1007/s00127-004-0782-0
   Goldberg D. P., 1988, USERS GUIDE GEN HLTH
   Goodman R, 2000, BRIT J PSYCHIAT, V177, P534, DOI 10.1192/bjp.177.6.534
   Goodman R, 2003, INT REV PSYCHIATR, V15, P166, DOI 10.1080/0954026021000046128
   Green H., 2005, MENTAL HLTH CHILDREN
   Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Humphrey N., 2010, EUROPEAN J SPECIAL N, V25, P77, DOI DOI 10.1080/08856250903450855
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Macintyre S, 1998, J EPIDEMIOL COMMUN H, V52, P657
   McCarthy J, 2010, RES DEV DISABIL, V31, P362, DOI 10.1016/j.ridd.2009.10.009
   MCCONAUGHY SH, 1992, J AM ACAD CHILD PSY, V31, P932, DOI 10.1097/00004583-199209000-00023
   National Statistics, 2006, HLTH SCI Q, V31, P28
   Office of National Statistics, 1996, LAB FORC SURV
   Rowley E, 2012, RES AUTISM SPECT DIS, V6, P1126, DOI 10.1016/j.rasd.2012.03.004
   Royston P., 2004, STATA J, V4, P227, DOI DOI 10.1037//1082-989X.7.2.147
   Rubin D., 1987, MULTIPLE IMPUTATION
   Rutter M., 2003, SOCIAL COMMUNICATION
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Snow AV, 2011, J AUTISM DEV DISORD, V41, P302, DOI 10.1007/s10803-010-1054-3
   Sparrow S. S., 1999, VINELAND SCREENER
   Taylor JL, 2010, J AUTISM DEV DISORD, V40, P1431, DOI 10.1007/s10803-010-1005-z
   Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
   VERHULST FC, 1990, J AM ACAD CHILD PSY, V29, P440, DOI 10.1097/00004583-199005000-00016
   Wechsler D., 2004, WECHSLER INTELLIGENC
   Wechsler D, 1999, WECHSLER ABBREVIATED
NR 37
TC 15
Z9 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD FEB
PY 2013
VL 54
IS 2
BP 186
EP 194
DI 10.1111/j.1469-7610.2012.02606.x
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 075FH
UT WOS:000313868700009
PM 22934711
ER

PT J
AU Fein, D
   Barton, M
   Eigsti, IM
   Kelley, E
   Naigles, L
   Schultz, RT
   Stevens, M
   Helt, M
   Orinstein, A
   Rosenthal, M
   Troyb, E
   Tyson, K
AF Fein, Deborah
   Barton, Marianne
   Eigsti, Inge-Marie
   Kelley, Elizabeth
   Naigles, Letitia
   Schultz, Robert T.
   Stevens, Michael
   Helt, Molly
   Orinstein, Alyssa
   Rosenthal, Michael
   Troyb, Eva
   Tyson, Katherine
TI Optimal outcome in individuals with a history of autism
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism; outcome; optimal
ID INTENSIVE BEHAVIORAL TREATMENT; PERVASIVE DEVELOPMENTAL DISORDERS;
   SPECTRUM DISORDERS; ASPERGER-SYNDROME; YOUNG-CHILDREN; COMMUNICATION;
   ADOLESCENTS; HANDEDNESS; DIAGNOSIS; DEFICITS
AB Background: Although autism spectrum disorders (ASDs) are generally considered lifelong disabilities, literature suggests that a minority of individuals with an ASD will lose the diagnosis. However, the existence of this phenomenon, as well as its frequency and interpretation, is still controversial: were they misdiagnosed initially, is this a rare event, did they lose the full diagnosis, but still suffer significant social and communication impairments or did they lose all symptoms of ASD and function socially within the normal range? Methods: The present study documents a group of these optimal outcome individuals (OO group, n = 34) by comparing their functioning on standardized measures to age, sex, and nonverbal IQ matched individuals with high-functioning autism (HFA group, n = 44) or typical development (TD group, n = 34). For this study, optimal outcome requires losing all symptoms of ASD in addition to the diagnosis, and functioning within the nonautistic range of social interaction and communication. Domains explored include language, face recognition, socialization, communication, and autism symptoms. Results: Optimal outcome and TD groups mean scores did not differ on socialization, communication, face recognition, or most language subscales, although three OO individuals showed below-average scores on face recognition. Early in their development, the OO group displayed milder symptoms than the HFA group in the social domain, but had equally severe difficulties with communication and repetitive behaviors. Conclusions: Although possible deficits in more subtle aspects of social interaction or cognition are not ruled out, the results substantiate the possibility of OO from autism spectrum disorders and demonstrate an overall level of functioning within normal limits for this group.
C1 [Fein, Deborah; Barton, Marianne; Eigsti, Inge-Marie; Naigles, Letitia; Helt, Molly; Orinstein, Alyssa; Troyb, Eva] Univ Connecticut, Dept Psychol, Storrs, CT 06268 USA.
   [Kelley, Elizabeth] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada.
   [Schultz, Robert T.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA USA.
   [Stevens, Michael] Hartford Hosp, Inst Living, Hartford, CT 06115 USA.
   [Fein, Deborah] Univ Connecticut, Dept Pediat, Storrs, CT 06268 USA.
RP Fein, D (reprint author), Univ Connecticut, Dept Psychol, Storrs, CT 06268 USA.
EM deborah.fein@uconn.edu
FU  [NIH R01 MH076189]
FX The authors are very grateful to the participants and their families, to
   Dr. Lynn Brennan and Harriet Levin for help with recruitment, to our
   invaluable undergraduate research assistants, and for our grant funding:
   NIH R01 MH076189. The authors have declared that they have no competing
   or potential conflicts of interest to disclose.
CR Benton A.L., 1994, CONTRIBUTIONS NEUROP
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
   Cederlund M, 2008, J AUTISM DEV DISORD, V38, P72, DOI 10.1007/s10803-007-0364-6
   Cohen H, 2006, J DEV BEHAV PEDIATR, V27, pS145, DOI 10.1097/00004703-200604002-00013
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
   Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
   Eden GF, 2004, NEURON, V44, P411, DOI 10.1016/j.neuron.2004.10.019
   Eikeseth S, 2007, BEHAV MODIF, V31, P264, DOI 10.1177/0145445506291396
   Escalante-Mead PR, 2003, J AUTISM DEV DISORD, V33, P539, DOI 10.1023/A:1025887713788
   FEIN D, 1985, J AUTISM DEV DISORD, V15, P323, DOI 10.1007/BF01531502
   Fein D, 2005, J AUTISM DEV DISORD, V35, P525, DOI 10.1007/s10803-005-5066-3
   Fountain C, 2012, PEDIATRICS, V129, pE1112, DOI 10.1542/peds.2011-1601
   Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
   Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Ivar Lovaas O., 1987, J CONSULT CLIN PSYCH, V55, P3, DOI DOI 10.1037//0022-006X.55.13
   Kelley E, 2010, RES AUTISM SPECT DIS, V4, P526, DOI 10.1016/j.rasd.2009.12.001
   Kelley E, 2006, J AUTISM DEV DISORD, V36, P807, DOI 10.1007/s10803-006-0111-4
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   VENTER A, 1992, J CHILD PSYCHOL PSYC, V33, P489, DOI 10.1111/j.1469-7610.1992.tb00887.x
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luyster R, 2005, DEV NEUROPSYCHOL, V27, P311, DOI 10.1207/s15326942dn2703_2
   Mraz KD, 2009, J CHILD NEUROL, V24, P833, DOI 10.1177/0883073808331345
   MUNDY P, 1993, AM J MENT RETARD, V97, P381
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Piven J, 1996, J AM ACAD CHILD PSY, V35, P523, DOI 10.1097/00004583-199604000-00019
   RUTTER M, 1970, SEMIN PSYCHIAT, V2, P435
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   Saulnier CA, 2007, J AUTISM DEV DISORD, V37, P788, DOI 10.1007/s10803-006-0288-6
   Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
   Semel E., 2003, CLIN EVALUATION LANG, V4th
   Sigman M, 1999, MONOGR SOC RES CHILD, V64, P1, DOI 10.1111/1540-5834.00002
   Sparrow S., 1985, VINELAND ADAPTIVE BE
   Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
   SZATMARI P, 1989, DEV MED CHILD NEUROL, V31, P709
   Turner LM, 2007, J CHILD PSYCHOL PSYC, V48, P793, DOI 10.1111/j.1469-7610.2007.01744.x
   Watt N, 2008, J AUTISM DEV DISORD, V38, P1518, DOI 10.1007/s10803-007-0532-8
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Zappella M., 1999, INFANTO, V7, P61
NR 41
TC 51
Z9 53
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD FEB
PY 2013
VL 54
IS 2
BP 195
EP 205
DI 10.1111/jcpp.12037
PG 11
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 075FH
UT WOS:000313868700010
PM 23320807
ER

PT J
AU Georgiades, S
   Szatmari, P
   Boyle, M
   Hanna, S
   Duku, E
   Zwaigenbaum, L
   Bryson, S
   Fombonne, E
   Volden, J
   Mirenda, P
   Smith, I
   Roberts, W
   Vaillancourt, T
   Waddell, C
   Bennett, T
   Thompson, A
AF Georgiades, Stelios
   Szatmari, Peter
   Boyle, Michael
   Hanna, Steven
   Duku, Eric
   Zwaigenbaum, Lonnie
   Bryson, Susan
   Fombonne, Eric
   Volden, Joanne
   Mirenda, Pat
   Smith, Isabel
   Roberts, Wendy
   Vaillancourt, Tracy
   Waddell, Charlotte
   Bennett, Teresa
   Thompson, Ann
CA Pathways ASD Study Team
TI Investigating phenotypic heterogeneity in children with autism spectrum
   disorder: a factor mixture modeling approach
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Symptomatology; Autistic disorder; Classification; Diagnosis; DSM
ID SYMPTOM MODEL; CLASSIFICATION; DIMENSIONS; CATEGORIES; SEVERITY;
   CRITERIA; SUBTYPES; ISSUES; DSM-5
AB Background: Autism spectrum disorder (ASD) is characterized by notable phenotypic heterogeneity, which is often viewed as an obstacle to the study of its etiology, diagnosis, treatment, and prognosis. On the basis of empirical evidence, instead of three binary categories, the upcoming edition of the DSM 5 will use two dimensions social communication deficits (SCD) and fixated interests and repetitive behaviors (FIRB) for the ASD diagnostic criteria. Building on this proposed DSM 5 model, it would be useful to consider whether empirical data on the SCD and FIRB dimensions can be used within the novel methodological framework of Factor Mixture Modeling (FMM) to stratify children with ASD into more homogeneous subgroups. Methods: The study sample consisted of 391 newly diagnosed children (mean age 38.3 months; 330 males) with ASD. To derive subgroups, data from the Autism Diagnostic Interview-Revised indexing SCD and FIRB were used in FMM; FMM allows the examination of continuous dimensions and latent classes (i.e., categories) using both factor analysis (FA) and latent class analysis (LCA) as part of a single analytic framework. Results: Competing LCA, FA, and FMM models were fit to the data. On the basis of a set of goodness-of-fit criteria, a two-factor/three-class factor mixture model provided the overall best fit to the data. This model describes ASD using three subgroups/classes (Class 1: 34%, Class 2: 10%, Class 3: 56% of the sample) based on differential severity gradients on the SCD and FIRB symptom dimensions. In addition to having different symptom severity levels, children from these subgroups were diagnosed at different ages and were functioning at different adaptive, language, and cognitive levels. Conclusions: Study findings suggest that the two symptom dimensions of SCD and FIRB proposed for the DSM 5 can be used in FMM to stratify children with ASD empirically into three relatively homogeneous subgroups.
C1 [Georgiades, Stelios; Szatmari, Peter; Boyle, Michael; Hanna, Steven; Duku, Eric; Bennett, Teresa; Thompson, Ann] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8N 3Z5, Canada.
   [Georgiades, Stelios; Szatmari, Peter; Boyle, Michael; Hanna, Steven; Duku, Eric; Bennett, Teresa; Thompson, Ann] McMaster Univ, Offord Ctr Child Studies, Hamilton, ON L8N 3Z5, Canada.
   [Zwaigenbaum, Lonnie; Volden, Joanne] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.
   [Bryson, Susan; Smith, Isabel] Dalhousie Univ, Dept Pediat, Halifax, NS, Canada.
   [Bryson, Susan; Smith, Isabel] Dalhousie Univ, Dept Psychol, Halifax, NS, Canada.
   [Bryson, Susan; Smith, Isabel] IWK Hlth Ctr, Halifax, NS, Canada.
   [Fombonne, Eric] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Fombonne, Eric] McGill Univ, Dept Pediat, Montreal, PQ H3A 2T5, Canada.
   [Mirenda, Pat] Univ British Columbia, Dept Educ & Counselling Psychol & Special Educ, Vancouver, BC V5Z 1M9, Canada.
   [Roberts, Wendy] Univ Toronto, Dept Pediat, Toronto, ON, Canada.
   [Roberts, Wendy] Univ Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil Hosp, Toronto, ON, Canada.
   [Vaillancourt, Tracy] Univ Ottawa, Fac Educ, Ottawa, ON, Canada.
   [Waddell, Charlotte] Simon Fraser Univ, Fac Hlth Sci, Vancouver, BC, Canada.
RP Szatmari, P (reprint author), McMaster Univ, Offord Ctr Child Studies, Chedoke Site,Patterson Bldg,1200 Main St W, Hamilton, ON L8N 3Z5, Canada.
EM szatmar@mcmaster.ca
RI Vaillancourt, Tracy/F-8949-2015
FU Canadian Institutes of Health Research; Autism Speaks; Government of
   British Columbia; Alberta Innovates Health Solutions; Sinneave Family
   Foundation; Autism Research Training (ART) fellowship by the Canadian
   Institutes of Health Research
FX This study was supported by the Canadian Institutes of Health Research,
   Autism Speaks, the Government of British Columbia, the Alberta Innovates
   Health Solutions, and the Sinneave Family Foundation. Stelios Georgiades
   is supported by an Autism Research Training (ART) fellowship by the
   Canadian Institutes of Health Research. The authors thank all the
   families who participated in the Pathways in ASD study. The authors also
   acknowledge the members of the Pathways in ASD Study Team. These members
   had equal contribution to the study and are listed here alphabetically:
   Liliana Abruzzese, Megan Alexander, Susan Bauld, Ainsley Boudreau, Colin
   Andrew Campbell, Mike Chalupka, Lorna Colli, Melanie Couture, Bev
   DaSilva, Vikram Dua, Miriam Elfert, Lara El-Khatib, Lindsay Fleming,
   Kristin Fossum, Nancy Garon, Shareen Holly, Stephanie Jull, Karen
   Kalynchuk, Kathryne MacLeod, Preetinder Narang, Julianne Noseworthy,
   Irene O'Connor, Kaori Ohashi, Sarah Peacock, Teri Phillips, Sara Quirke,
   Katie Rinald, Jennifer Saracino, Cathryn Schroeder, Cody Shepherd,
   Rebecca Simon, Mandy Steiman, Richard Stock, Benjamin Taylor, Lee
   Tidmarsh, Larry Tuff, Kathryn Vaillancourt, Stephen Wellington, Isabelle
   Yun, and Li Hong Zhong.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2011, REP DSM 5 NEUR DIS W
   Boomsma A, 2008, J CHILD PSYCHOL PSYC, V49, P809, DOI 10.1111/j.1469-7610.2008.01897.x
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Frazier TW, 2008, J AUTISM DEV DISORD, V38, P474, DOI 10.1007/s10803-007-0415-z
   Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
   Georgiades S, 2011, J AUTISM DEV DISORD, V41, P1321, DOI 10.1007/s10803-010-1158-9
   Georgiades S, 2007, J AM ACAD CHILD PSY, V46, P188, DOI 10.1097/01.chi.0000242236.90763.7f
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Happe F, 2011, J AM ACAD CHILD PSY, V50, P540, DOI 10.1016/j.jaac.2011.03.015
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Ingram G. D., 2008, J AUTISM DEV DISORD, V38, P950
   Kamp-Becker I, 2009, J AUTISM DEV DISORD, V39, P557, DOI 10.1007/s10803-008-0656-5
   Kamphuis JH, 2009, PSYCHOL ASSESSMENT, V21, P294, DOI 10.1037/a0016697
   Kraemer HC, 2007, INT J METH PSYCH RES, V16, pS8, DOI 10.1002/mpr.211
   Liu XQ, 2011, J AM ACAD CHILD PSY, V50, P687, DOI 10.1016/j.jaac.2011.05.002
   Lord C, 2012, J CHILD PSYCHOL PSYC, V53, P490, DOI 10.1111/j.1469-7610.2012.02547.x
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lubke G, 2010, STRUCT EQU MODELING, V17, P605, DOI 10.1080/10705511.2010.510050
   Lubke GH, 2008, ADVANCES IN LATENT VARIABLE MIXTURE MODELS, P343
   Lubke GH, 2005, PSYCHOL METHODS, V10, P21, DOI 10.1037/1082-989X.10.1.21
   Lubke GH, 2007, J AM ACAD CHILD PSY, V46, P1584, DOI 10.1097/chi.0b013e31815750dd
   Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x
   Munson J., 2008, AM J MENT RETARD, V113, P427
   Muthen B., 2004, HDB QUANTITATIVE MET, P346, DOI [10.4135/9781412986311.n19, DOI 10.4135/9781412986311.N19]
   Muthen L. K., 2007, MPLUS VERSION 5 0 US
   Newschaffer CJ, 2002, EPIDEMIOL REV, V24, P137, DOI 10.1093/epirev.mxf010
   Roid G. H., 2004, MERRILL PALMER REVIS
   Ruscio J, 2004, J ABNORM PSYCHOL, V113, P24, DOI 10.1037/0021-843X.113.1.24
   Rutter M., 2003, ADI R AUTISM DIAGNOS
   Rutter M, 2011, J CHILD PSYCHOL PSYC, V52, P647, DOI 10.1111/j.1469-7610.2011.02367.x
   Snow AV, 2009, J CHILD PSYCHOL PSYC, V50, P734, DOI 10.1111/j.1469-7610.2008.02018.x
   Sparrow S. S., 2005, SURVEY INTERVIEW CAR
   SPSS Inc, 2011, SPSS WIND REL 19
   Szatmari P, 2007, AM J MED GENET B, V144B, P581, DOI 10.1002/ajmg.b.30426
   Szatmari P, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d2456
   van Lang NDJ, 2006, J CHILD PSYCHOL PSYC, V47, P37, DOI 10.1111/j.1469-7610.2005.01434.x
   Volkmar FR, 2009, J CHILD PSYCHOL PSYC, V50, P108, DOI 10.1111/j.1469-7610.2008.02010.x
   Walton KE, 2011, J ABNORM CHILD PSYCH, V39, P553, DOI 10.1007/s10802-010-9478-y
   Wiggins L. D., 2011, J AUTISM DEV DISORD, V42, P191
   Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2
   Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 43
TC 21
Z9 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD FEB
PY 2013
VL 54
IS 2
BP 206
EP 215
DI 10.1111/j.1469-7610.2012.02588.x
PG 10
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 075FH
UT WOS:000313868700011
PM 22862778
ER

PT J
AU Hus, V
   Bishop, S
   Gotham, K
   Huerta, M
   Lord, C
AF Hus, Vanessa
   Bishop, Somer
   Gotham, Katherine
   Huerta, Marisela
   Lord, Catherine
TI Factors influencing scores on the social responsiveness scale
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Social Responsiveness Scale; autism spectrum disorder; behavior
   problems; age; language level
ID PERVASIVE DEVELOPMENTAL DISORDERS; AUTISM SPECTRUM DISORDERS;
   GENERAL-POPULATION; TRAITS; CHILDREN; IMPAIRMENT; VALIDATION; MULTIPLEX;
   SEVERITY; BEHAVIOR
AB Background: The Social Responsiveness Scale (SRS) is a parent-completed screening questionnaire often used to measure autism spectrum disorders (ASD) severity. Although child characteristics are known to influence scores from other ASD-symptom measures, as well as parent-questionnaires more broadly, there has been limited consideration of how non-ASD-specific factors may affect interpretation of SRS scores. Previous studies have explored effects of behavior problems on SRS specificity, but have not addressed influences on the use of the SRS as a quantitative measure of ASD-symptoms. Method: Raw scores (SRS-Raw) from parent-completed SRS were analyzed for 2,368 probands with ASD and 1,913 unaffected siblings. Regression analyses were used to assess associations between SRS scores and demographic, language, cognitive, and behavior measures. Results: For probands, higher SRS-Raw were associated with greater non-ASD behavior problems, higher age, and more impaired language and cognitive skills, as well as scores from other parent report measures of social development and ASD-symptoms. For unaffected siblings, having more behavior problems predicted higher SRS-Raw; male gender, younger age, and poorer adaptive social and expressive communication skills also showed small, but significant effects. Conclusions: When using the SRS as a quantitative phenotype measure, the influence of behavior problems, age, and expressive language or cognitive level on scores must be considered. If effects of non-ASD-specific factors are not addressed, SRS scores are more appropriately interpreted as indicating general levels of impairment, than as severity of ASD-specific symptoms or social impairment. Additional research is needed to consider how these factors influence the SRS sensitivity and specificity in large, clinical samples including individuals with disorders other than ASD.
C1 [Hus, Vanessa; Gotham, Katherine] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
   [Bishop, Somer] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA.
   [Huerta, Marisela; Lord, Catherine] Weill Cornell Med Sch, Dept Psychiat, New York, NY USA.
RP Hus, V (reprint author), 530 Church St, Ann Arbor, MI 48109 USA.
EM vhus@umich.edu
FU Simons Foundation; Autism Speaks; NICHD [R01HD065277]; NIMH
   [R01MH081873, RC1 MH089721]
FX This research was supported by graduate fellowships from the Simons
   Foundation and Autism Speaks to VH, NICHD grant R01HD065277 to SB, and
   Simons Foundation and NIMH grants R01MH081873 and RC1 MH089721 to CL. We
   gratefully acknowledge Andrew Pickles for statistical consultation,
   Nicole Saghy for help preparing this manuscript, and the SSC families
   and principal investigators (A. Beaudet, R. Bernier, J. Constantino, E.
   Cook, E. Fombonne, D. Geschwind, D. Grice, A. Klin, D. Ledbetter, C.
   Martin, D. Martin, R. Maxim, J. Miles, O. Ousley, B. Peterson, J.
   Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, E.
   Wijsman). We appreciate obtaining access to phenotypic data on SFARI
   Base. Approved researchers can obtain the SSC dataset described in this
   study (https://ordering.base.sfari.org/similar to
   browse_collection/archive[sfari_collection_v12]/ui:-view()) by applying
   at https://base.sfari.org.
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
   Aylward GP, 2009, J DEV BEHAV PEDIATR, V30, P169, DOI 10.1097/DBP.0b013e31819f1c3e
   Bolte S, 2008, AUTISM RES, V1, P354, DOI 10.1002/aur.49
   Charman T, 2007, BRIT J PSYCHIAT, V191, P554, DOI 10.1192/bjp.bp.107.040196
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Constantino J. N., 2011, PEDIATR RES, V69, P55, DOI DOI 10.1203/PDR.0B013E318212EC6E
   Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
   Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x
   Constantino JN, 2003, J AM ACAD CHILD PSY, V42, P458, DOI 10.1097/01.CHI.0000046811.95464.21
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
   Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
   Constantino JN, 2007, J AM ACAD CHILD PSY, V46, P1668, DOI 10.1097/chi.0b013e318157cb23
   Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
   Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x
   Duvall JA, 2007, AM J PSYCHIAT, V164, P656, DOI 10.1176/appi.ajp.164.4.656
   Georgiades S., 2010, J AUTISM DEV DISORD, V41, P1321
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Grzadzinski R, 2011, J AUTISM DEV DISORD, V41, P1178, DOI 10.1007/s10803-010-1135-3
   Hus V, 2013, J AUTISM DEV DISORD, V43, P371, DOI 10.1007/s10803-012-1576-y
   Kanne SM, 2011, J AUTISM DEV DISORD, V41, P1007, DOI 10.1007/s10803-010-1126-4
   Kanne SM, 2009, J AUTISM DEV DISORD, V39, P856, DOI 10.1007/s10803-009-0694-7
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Mayes SD, 2010, RES AUTISM SPECT DIS, V5, P749
   Rea L. M., 1992, DESIGNING CONDUCTING
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Veenstra-VanderWeele J, 2011, J AM ACAD CHILD PSY, V50, P326, DOI 10.1016/j.jaac.2011.01.016
   Virkud YV, 2009, AM J MED GENET B, V150B, P328, DOI 10.1002/ajmg.b.30810
   Warren Z, 2012, AUTISM RES, V5, P31, DOI 10.1002/aur.230
NR 32
TC 24
Z9 24
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD FEB
PY 2013
VL 54
IS 2
BP 216
EP 224
DI 10.1111/j.1469-7610.2012.02589.x
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 075FH
UT WOS:000313868700012
PM 22823182
ER

PT J
AU Kang, S
   O'Reilly, M
   Rojeski, L
   Blenden, K
   Xu, ZW
   Davis, T
   Sigafoos, J
   Lancioni, G
AF Kang, Soyeon
   O'Reilly, Mark
   Rojeski, Laura
   Blenden, Kara
   Xu, Ziwei
   Davis, Tonya
   Sigafoos, Jeff
   Lancioni, Giulio
TI Effects of tangible and social reinforcers on skill acquisition,
   stereotyped behavior, and task engagement in three children with autism
   spectrum disorders
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorders; Task engagement; Tangible reinforcement;
   Social reinforcement; Skill acquisition; Stereotyped behavior
ID PREFERENCE ASSESSMENTS; INDIVIDUALS; STIMULI
AB Children with autism spectrum disorders (ASDs) are more likely to engage in inappropriate play (e.g., stereotypy, repetitive behavior) with their preferred items given as reinforcers. Considering the stereotyped behavior is a core characteristic of ASD aimed to reduce, it is necessary to identify alternative reinforcers that does riot encourage problematic behavior as well as is still effective. In this respect, the present study evaluates a possible alternative reinforcer: social interaction. The study compared the effects of preferred tangible and social reinforcers on skill acquisition, stereotyped behavior, and task engagement during the instruction period in three children, 3-8 years of age, with ASDs. This study had two phases: in the first phase, preference assessments and reinforcer assessments were conducted to identify the most highly preferred items and relative preferred type of reinforcers. In the second phase, teachers taught the target skills using two different reinforcers and the three dependent variables were compared between two reinforcer conditions. The results suggest that the reinforcers were equally effective; however tangible reinforcers resulted in high levels of stereotyped behavior. The results indicate that social reinforcers can be efficient reinforcers for the population. The study discussed making an efficient reinforcement decision for individuals with ASD. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Kang, Soyeon] Univ Texas Austin, Dept Special Educ, Meadows Ctr Preventing Educ Risk, Austin, TX 78712 USA.
   [Davis, Tonya] Baylor Univ, Waco, TX 76798 USA.
   [Sigafoos, Jeff] Victoria Univ Wellington, Wellington, New Zealand.
   [Lancioni, Giulio] Univ Bari, I-70121 Bari, Italy.
RP Kang, S (reprint author), Univ Texas Austin, Dept Special Educ, Meadows Ctr Preventing Educ Risk, 1912 Speedway STOP D5300, Austin, TX 78712 USA.
EM syk77@austin.utexas.edu
CR DeLeon IG, 2001, J APPL BEHAV ANAL, V34, P463, DOI 10.1901/jaba.2001.34-463
   Dube WV, 2004, BEHAV ANALYST, V27, P197
   FERRARI M, 1981, J APPL BEHAV ANAL, V14, P339, DOI 10.1901/jaba.1981.14-339
   Hausman N., 2009, EDUC TREAT CHILD, V32, P77, DOI [10.1353/etc.0.0051, DOI 10.1353/ETC.0.0051]
   Kennedy CH, 2000, J APPL BEHAV ANAL, V33, P559, DOI 10.1901/jaba.2000.33-559
   Koegel RL, 2009, J AUTISM DEV DISORD, V39, P1240, DOI 10.1007/s10803-009-0732-5
   Nuernberger JE, 2012, BEHAV INTERVENT, V27, P33, DOI 10.1002/bin.1336
   Rapp JT, 2004, J APPL BEHAV ANAL, V37, P481, DOI 10.1901/jaba.2004.37-481
   Rodriguez NM, 2012, J APPL BEHAV ANAL, V45, P1, DOI 10.1901/jaba.2012.45-1
   Roscoe EM, 1999, J APPL BEHAV ANAL, V32, P479, DOI 10.1901/jaba.1999.32-479
   Smaby K, 2007, BEHAV INTERVENT, V22, P311, DOI 10.1002/bin.242
   Tarbox RSF, 2007, J APPL BEHAV ANAL, V40, P761, DOI 10.1901/jaba.2007.761-765
   White P., 2010, RES AUTISM SPECT DIS, V<IT>5</IT>, P784
NR 13
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD FEB
PY 2013
VL 34
IS 2
BP 739
EP 744
DI 10.1016/j.ridd.2012.10.007
PG 6
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 076YI
UT WOS:000313994700003
PM 23220050
ER

PT J
AU Gonzalez-Gadea, ML
   Baez, S
   Torralva, T
   Castellanos, FX
   Rattazzi, A
   Bein, V
   Rogg, K
   Manes, F
   Ibanez, A
AF Luz Gonzalez-Gadea, Maria
   Baez, Sandra
   Torralva, Teresa
   Castellanos, Francisco Xavier
   Rattazzi, Alexia
   Bein, Victoria
   Rogg, Katharina
   Manes, Facundo
   Ibanez, Agustin
TI Cognitive variability in adults with ADHD and AS: Disentangling the
   roles of executive functions and social cognition
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Attention-deficit hyperactivity disorder; Asperger Syndrome; Social
   cognition; Executive functions; Theory of mind; Inter-individual
   variability; Cognitive heterogeneity
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
   DISORDER; AUTISM SPECTRUM DISORDERS; INTRA-SUBJECT VARIABILITY; CARD
   SORTING TEST; ASPERGER-SYNDROME; DECISION-MAKING; WORKING-MEMORY;
   INTRAINDIVIDUAL VARIABILITY; EMOTION RECOGNITION
AB Attention-deficit/hyperactivity disorder (ADHD) and Asperger's Syndrome (AS) share a heterogeneous cognitive profile. Studies assessing executive functions (EF) and social cognition in both groups have found preserved and impaired performances. These inconsistent findings would be partially explained by the cognitive variability reported in these disorders. First, the present study explored the inter-individual variability in EF and social cognition in both patient groups. Second, we compared differential characteristics and commonalities in the cognitive profiles of EF and social cognition between ADHD, AS and control adults. We assessed 22 patients with ADHD, 23 adults with AS and 21 matched typically developing subjects using different measures of EF (working memory, cognitive flexibility and multitasking) and social cognition (theory of mind and decision-making). Group comparisons and multiple case series analyses (MCSA) were conducted. The between-group comparisons showed an EF deficit in working memory in ADHD and a theory of mind (ToM) impairment in AS. The MCSA evidenced that, compared to controls, ADHD patients had a higher inter-individual variability in EF, while individuals with AS had a more heterogeneous profile in social cognition tasks compared to both groups. Finally, the AS and ADHD groups presented higher task-related variability compared to controls and shared a common heterogeneous profile in EF. This is the first study to compare variability in EF and social cognition profiles of ADHD and AS. We propose that heterogeneity in EF performance is a link between ADHD and AS which may explain the overlap of symptomatology between both diagnoses. In addition, patients with AS seem to show a unique heterogeneous profile in ToM which may explain the low probability of finding AS symptoms in patients with ADHD. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Luz Gonzalez-Gadea, Maria; Baez, Sandra; Torralva, Teresa; Manes, Facundo; Ibanez, Agustin] Inst Cognit Neurol INECO, Lab Expt Psychol & Neurosci LPEN, Buenos Aires, DF, Argentina.
   [Luz Gonzalez-Gadea, Maria; Baez, Sandra; Ibanez, Agustin] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF, Argentina.
   [Luz Gonzalez-Gadea, Maria; Ibanez, Agustin] Univ Nacl Cordoba UNC, Fac Chem Sci, Cordoba, Argentina.
   [Torralva, Teresa; Manes, Facundo] Favaloro Univ, Inst Neurociences, Buenos Aires, DF, Argentina.
   [Castellanos, Francisco Xavier] NYU, Langone Med Ctr, Ctr Child Study, New York, NY USA.
   [Castellanos, Francisco Xavier] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA.
   [Rattazzi, Alexia; Bein, Victoria] PANAACEA, Buenos Aires, DF, Argentina.
   [Rogg, Katharina] Univ Wurzburg, Wurzburg, Germany.
   [Ibanez, Agustin] Univ Diego Portales, Lab Cognit & Social Neurosci, Santiago, Chile.
RP Ibanez, A (reprint author), Pacheco de Melo 1854-60,C1126AAB, Buenos Aires, DF, Argentina.
EM mgonzalez@ineco.org.ar; sbaez@ineco.org.ar; ttorralva@ineco.org.ar;
   Francisco.Castellanos@nyumc.org; alexiarattazzi@panaacea.org;
   victoriabein@gmail.com; katharina.rogg@googlemail.com;
   fmanes@ineco.org.ar; aibanez@ineco.org.ar
CR Alloway TP, 2011, CHILD NEUROPSYCHOL, V17, P483, DOI 10.1080/09297049.2011.553590
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Ames CS, 2011, J AUTISM DEV DISORD, V41, P357, DOI 10.1007/s10803-010-1049-0
   Baez S, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00302
   Bálint Sára, 2008, Psychiatr Hung, V23, P324
   Barkley RA, 1997, PSYCHOL BULL, V121, P65, DOI 10.1037//0033-2909.121.1.65
   Baron-Cohen S, 2005, J AUTISM DEV DISORD, V35, P807, DOI 10.1007/s10803-005-0026-5
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
   BECHARA A, 1994, COGNITION, V50, P7, DOI 10.1016/0010-0277(94)90018-3
   Braver TS, 2012, TRENDS COGN SCI, V16, P106, DOI 10.1016/j.tics.2011.12.010
   Buitelaar JK, 1996, EUR CHILD ADOLES PSY, V5, P44
   Burin DI, 2000, J CLIN EXP NEUROPSYC, V22, P677, DOI 10.1076/1380-3395(200010)22:5;1-9;FT677
   Castellanos FX, 2005, BIOL PSYCHIAT, V57, P1416, DOI 10.1016/j.biopsych.2004.12.005
   Castellanos FX, 2006, TRENDS COGN SCI, V10, P117, DOI 10.1016/j.tics.2006.01.011
   Castellanos FX, 2012, TRENDS COGN SCI, V16, P17, DOI 10.1016/j.tics.2011.11.007
   Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005
   Cortese S., 2012, AM J PSYCHIAT
   Desjardins C, 2010, J ATTEN DISORD, V14, P220, DOI 10.1177/1087054709347167
   Di Martino A, 2008, BIOL PSYCHIAT, V64, P607, DOI 10.1016/j.biopsych.2008.03.008
   Dyck MJ, 2001, EUR CHILD ADOLES PSY, V10, P105
   Ehlers S, 1997, J CHILD PSYCHOL PSYC, V38, P207, DOI 10.1111/j.1469-7610.1997.tb01855.x
   Ernst M, 2003, AM J PSYCHIAT, V160, P1061, DOI 10.1176/appi.ajp.160.6.1061
   Gargaro BA, 2011, NEUROSCI BIOBEHAV R, V35, P1081, DOI 10.1016/j.neubiorev.2010.11.002
   Gawrilow Caterina, 2011, Atten Defic Hyperact Disord, V3, P253, DOI 10.1007/s12402-011-0056-0
   Geurts H., 2010, EUROPEAN J DEV PSYCH, V7, P131
   Geurts HM, 2008, NEUROPSYCHOLOGIA, V46, P3030, DOI 10.1016/j.neuropsychologia.2008.06.013
   Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006
   Gillberg C, 2000, ACTA PSYCHIAT SCAND, V102, P321, DOI 10.1034/j.1600-0447.2000.102005321.x
   Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hartley SL, 2009, AUTISM, V13, P485, DOI 10.1177/1362361309335717
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Hill EL, 2006, NEUROPSYCHOLOGIA, V44, P2822, DOI 10.1016/j.neuropsychologia.2006.06.007
   Ibanez A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037306
   Ibanez A, 2011, SOC NEUROSCI-UK, V6, P464, DOI 10.1080/17470919.2011.620769
   Johnson SA, 2006, J INT NEUROPSYCH SOC, V12, P668, DOI 10.1017/S1355617706060802
   Kaland N, 2008, J AUTISM DEV DISORD, V38, P1161, DOI 10.1007/s10803-007-0474-1
   Klein C, 2006, BIOL PSYCHIAT, V60, P1088, DOI 10.1016/j.biopsych.2006.04.003
   Kofman O, 2008, J CLIN EXP NEUROPSYC, V30, P261, DOI 10.1080/13803390701380583
   Liss M, 2001, J CHILD PSYCHOL PSYC, V42, P261, DOI 10.1017/S0021963001006679
   Mantyla T, 2012, J ATTEN DISORD, V16, P164, DOI 10.1177/1087054709360494
   Martinussen R, 2005, J AM ACAD CHILD PSY, V44, P377, DOI 10.1097/01.chi.0000153228.72591.73
   Masunami T, 2009, INT J PSYCHOPHYSIOL, V72, P283, DOI 10.1016/j.ijpsycho.2009.01.007
   Matthies S, 2012, J BEHAV THER EXP PSY, V43, P938, DOI 10.1016/j.jbtep.2012.02.002
   Mayes SD, 2012, RES AUTISM SPECT DIS, V6, P277, DOI 10.1016/j.rasd.2011.05.009
   Memari Amirhossein, 2012, J Child Adolesc Psychiatr Nurs, V25, P84, DOI 10.1111/j.1744-6171.2012.00325.x
   Mikami AY, 2010, CLIN CHILD FAM PSYCH, V13, P181, DOI 10.1007/s10567-010-0067-y
   NELSON HE, 1976, CORTEX, V12, P313
   Nigg JT, 2005, BIOL PSYCHIAT, V57, P1424, DOI 10.1016/j.biopsych.2004.11.011
   Nigg JT, 2002, J AM ACAD CHILD PSY, V41, P59, DOI 10.1097/00004583-200201000-00012
   Nigg JT, 2005, BIOL PSYCHIAT, V57, P1224, DOI 10.1016/j.biopsych.2004.08.025
   Nijmeijer JS, 2008, CLIN PSYCHOL REV, V28, P692, DOI 10.1016/j.cpr.2007.10.003
   Nijmeijer JS, 2009, J ABNORM CHILD PSYCH, V37, P443, DOI 10.1007/s10802-008-9282-0
   Nyden A, 2010, RES DEV DISABIL, V31, P1659, DOI 10.1016/j.ridd.2010.04.010
   Partington J. E., 1949, PSYCHOL SERVICE CTR, V1, P9
   Ponnet KS, 2004, AUTISM, V8, P249, DOI 10.1177/1362361304045214
   Rajendran G, 2007, DEV REV, V27, P224, DOI 10.1016/j.dr.2007.02.001
   Rajendran G, 2005, J AUTISM DEV DISORD, V35, P429, DOI 10.1007/s10803-005-5033-z
   Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
   Semrud-Clikeman M, 2010, J AUTISM DEV DISORD, V40, P1017, DOI 10.1007/s10803-010-0951-9
   Sergeant JA, 2002, BEHAV BRAIN RES, V130, P3, DOI 10.1016/S0166-4328(01)00430-2
   SHALLICE T, 1978, CORTEX, V14, P294
   Siklos S, 2004, ARCH CLIN NEUROPSYCH, V19, P347, DOI 10.1016/S0887-6177(03)00071-4
   Soliva JC, 2009, ANN NY ACAD SCI, V1167, P212, DOI 10.1111/j.1749-6632.2009.04604.x
   Solomon M, 2011, AUTISM RES, V4, P109, DOI 10.1002/aur.177
   Sonuga-Barke EJS, 2005, BIOL PSYCHIAT, V57, P1231, DOI 10.1016/j.biopsych.2004.09.008
   Sonuga-Barke EJS, 2008, CHILD ADOL PSYCH CL, V17, P367, DOI 10.1016/j.chc.2007.11.008
   Sonuga-Barke EJS, 2002, BEHAV BRAIN RES, V130, P29, DOI 10.1016/S0166-4328(01)00432-6
   Spek AA, 2010, J AUTISM DEV DISORD, V40, P280, DOI 10.1007/s10803-009-0860-y
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   Taurines R., 2012, ADHD ATTENTION DEFIC
   Torralva T., 2012, PSYCHIAT RES
   Torralva T, 2011, PSYCHIAT RES, V186, P261, DOI 10.1016/j.psychres.2010.08.007
   Torralva T, 2009, BRAIN, V132, P1299, DOI 10.1093/brain/awp041
   Torralva T., 2012, J ATTENTION DISORDER
   Towgood KJ, 2009, NEUROPSYCHOLOGIA, V47, P2981, DOI 10.1016/j.neuropsychologia.2009.06.028
   Uekermann J, 2010, NEUROSCI BIOBEHAV R, V34, P734, DOI 10.1016/j.neubiorev.2009.10.009
   Verte S, 2006, J NEUROSCI METH, V151, P5, DOI 10.1016/j.jneumeth.2005.08.023
   Weschler D., 2007, WECHSLER ADULT INTEL
   Willcutt Erik G., 2008, V24, P195, DOI 10.1159/000118526
   Willcutt EG, 2005, BIOL PSYCHIAT, V57, P1336, DOI 10.1016/j.biopsych.2005.02.006
   Zalla T, 2009, J AUTISM DEV DISORD, V39, P373, DOI 10.1007/s10803-008-0634-y
   Zalla T, 2009, RES AUTISM SPECT DIS, V3, P913, DOI 10.1016/j.rasd.2009.03.004
NR 85
TC 10
Z9 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD FEB
PY 2013
VL 34
IS 2
BP 817
EP 830
DI 10.1016/j.ridd.2012.11.009
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 076YI
UT WOS:000313994700012
PM 23220737
ER

PT J
AU Lugnegard, T
   Hallerback, MU
   Hjarthag, F
   Gillberg, C
AF Lugnegard, Tove
   Hallerback, Maria Unenge
   Hjarthag, Fredrik
   Gillberg, Christopher
TI Social cognition impairments in Asperger syndrome and schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Social cognition; Theory of mind; Asperger syndrome; Schizophrenia
ID HIGH-FUNCTIONING AUTISM; NEGATIVE SYMPTOMS; MENTAL STATES;
   NEURODEVELOPMENTAL HYPOTHESIS; 1ST-EPISODE SCHIZOPHRENIA; INTENTIONAL
   MOVEMENT; SPECTRUM DISORDERS; ANIMATED SHAPES; MIND; ATTRIBUTION
AB Social cognition impairments are well described in both autism spectrum disorders, including Asperger syndrome (AS), and in schizophrenia spectrum disorders. However, little is known about whether there are differences between the two groups of disorders regarding this ability. The aim of this study was to compare social cognition abilities in AS and schizophrenia. Fifty-three individuals (26 men, 27 women) with a clinical diagnosis of AS, 36 (22 men, 14 women) with a clinical diagnosis of schizophrenic psychosis, and 50 non-clinical controls (19 men, 31 women) participated in the study. Clinical diagnoses were confirmed either by Structured Clinical Interview on DSM-IV diagnosis or the Diagnostic Interview for Social and Communication Disorders. Verbal ability was assessed using the Vocabulary subtest of the WAIS-III. Two social cognition instruments were used: Reading the Mind in the Eyes Test (Eyes Test) and the Animations Task. On the Eyes Test, patients with schizophrenia showed poorer results compared to non-clinical controls; however, no other group differences were seen. Both clinical groups scored significantly lower than the comparison group on the Animations Task. The AS group performed somewhat better than the schizophrenia group. Some differences were accounted for by gender effects. Implicit social cognition impairments appear to be at least as severe in schizophrenia as they are in AS. Possible gender differences have to be taken into account in future research on this topic. (C) 2012 Elsevier B. V. All rights reserved.
C1 [Lugnegard, Tove; Hallerback, Maria Unenge; Gillberg, Christopher] Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
   [Lugnegard, Tove] Cent Hosp Karlstad, Dept Adult Habilitat, S-65225 Karlstad, Sweden.
   [Hallerback, Maria Unenge] Cent Hosp Karlstad, Dept Child & Adolescent Psychiat, S-65225 Karlstad, Sweden.
   [Hjarthag, Fredrik] Karlstad Univ, Dept Psychol, Karlstad, Sweden.
RP Lugnegard, T (reprint author), Cent Hosp Karlstad, Dept Adult Habilitat, Drottninggatan 27, S-65225 Karlstad, Sweden.
EM tove.lugnegard@liv.se
FU County Council of Varmland, Sweden
FX This study was supported by grants from the County Council of Varmland,
   Sweden. The funding source had no further role in study design; in the
   collection, analysis and interpretation of data; in writing the report;
   and in the decision to submit the paper for publication.
CR Abdi Z, 2004, CNS SPECTRUMS, V9, P335
   Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9
   (APA) APA, 2000, DIAGN STAT MAN MENT
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baron-Cohen S., 2001, J DEV LEARNING DISOR, V5, P47
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Bell M, 2009, SCHIZOPHRENIA BULL, V35, P738, DOI 10.1093/schbul/sbm169
   Bell MD, 2010, SCHIZOPHR RES, V122, P164, DOI 10.1016/j.schres.2010.03.024
   Bolte S, 2003, PSYCHOL MED, V33, P907, DOI 10.1017/S0033291703007438
   Bora E, 2008, J NERV MENT DIS, V196, P95, DOI 10.1097/NMD.0b013e318162a9e1
   Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27
   Castelli F, 2000, NEUROIMAGE, V12, P314, DOI 10.1006/nimg.2000.0612
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Coleman M., 2011, AUTISMS
   Couture SM, 2010, PSYCHOL MED, V40, P569, DOI 10.1017/S003329170999078X
   Couture SM, 2011, SCHIZOPHR RES, V125, P152, DOI 10.1016/j.schres.2010.09.020
   Couture SM, 2008, SCHIZOPHR RES, V100, P237, DOI 10.1016/j.schres.2007.12.484
   Couture SM, 2006, SCHIZOPHRENIA BULL, V32, pS44, DOI 10.1093/schbul/sb1029
   Craddock N, 2010, BRIT J PSYCHIAT, V196, P92, DOI 10.1192/bjp.bp.109.073429
   Craig JS, 2004, SCHIZOPHR RES, V69, P29, DOI 10.1016/S0920-9964(03)00154-3
   Dziobek I, 2006, J AUTISM DEV DISORD, V36, P623, DOI 10.1007/s10803-006-0107-0
   Fatemi SH, 2009, SCHIZOPHRENIA BULL, V35, P528, DOI 10.1093/schbul/sbn187
   Fernell E, 2010, RES DEV DISABIL, V31, P680, DOI 10.1016/j.ridd.2010.01.007
   Fett AKJ, 2011, NEUROSCI BIOBEHAV R, V35, P573, DOI 10.1016/j.neubiorev.2010.07.001
   First MB, 2004, COMPREHENSIVE HDB PS, V2
   Frith CD, 2007, CURR BIOL, V17, pR724, DOI 10.1016/j.cub.2007.05.068
   Frith CD, 2004, PSYCHOL MED, V34, P385, DOI 10.1017/S0033291703001326
   Green MF, 2008, SCHIZOPHRENIA BULL, V34, P1211, DOI 10.1093/schbul/sbm145
   Hallerback MU, 2012, PSYCHIAT RES, V198, P12, DOI 10.1016/j.psychres.2012.01.016
   Hallerbäck Maria Unenge, 2009, Cogn Neuropsychiatry, V14, P127, DOI 10.1080/13546800902901518
   HOLM S, 1979, SCAND J STAT, V6, P65
   Horan WP, 2009, PSYCHOL MED, V39, P635, DOI 10.1017/S0033291708003838
   Kelemen O, 2005, NEUROPSYCHOLOGY, V19, P494, DOI 10.1037/0894-4105.19.4.494
   Kettle JWL, 2008, SCHIZOPHR RES, V99, P96, DOI 10.1016/j.schres.2007.11.011
   Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101
   Koelkebeck K, 2010, SCHIZOPHR RES, V119, P115, DOI 10.1016/j.schres.2009.12.015
   Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
   McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
   Murphy David, 2006, Cogn Neuropsychiatry, V11, P99, DOI 10.1080/13546800444000182
   Owen MJ, 2011, BRIT J PSYCHIAT, V198, P173, DOI 10.1192/bjp.bp.110.084384
   Ozguven HD, 2010, KLIN PSIKOFARMAKOL B, V20, P5
   Penn DL, 2008, SCHIZOPHRENIA BULL, V34, P408, DOI 10.1093/schbul/sbn014
   Pett M. A., 1997, NONPARAMETRIC STAT H
   Pickup GJ, 2008, PSYCHOPATHOLOGY, V41, P206, DOI 10.1159/000125554
   Pilowsky T, 2000, SCHIZOPHR RES, V42, P145, DOI 10.1016/S0920-9964(99)00101-2
   Pinkham AE, 2008, SCHIZOPHR RES, V99, P164, DOI 10.1016/j.schres.2007.10.024
   Pinkham AE, 2003, AM J PSYCHIAT, V160, P815, DOI 10.1176/appi.ajp.160.5.815
   Pisula E, 2010, ACTA NEUROBIOL EXP, V70, P119
   Russell TA, 2006, SCHIZOPHR RES, V81, P101, DOI 10.1016/j.schres.2005.10.002
   Sasson N, 2007, NEUROPSYCHOLOGIA, V45, P2580, DOI 10.1016/j.neuropsychologia.2007.03.009
   Sergi MJ, 2007, SCHIZOPHR RES, V90, P316, DOI 10.1016/j.schres.2006.09.028
   Spek AA, 2010, J AUTISM DEV DISORD, V40, P280, DOI 10.1007/s10803-009-0860-y
   Sprong M, 2007, BRIT J PSYCHIAT, V191, P5, DOI 10.1192/bjp.bp.107.035899
   Tager-Flusberg H, 2007, CURR DIR PSYCHOL SCI, V16, P311, DOI 10.1111/j.1467-8721.2007.00527.x
   Wechsler D, 1997, MANUAL WECHSLER ADUL
   Williams D, 2010, AUTISM, V14, P285, DOI 10.1177/1362361309344849
   Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
   Wright B, 2008, AUTISM, V12, P607, DOI 10.1177/1362361308097118
NR 58
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD FEB
PY 2013
VL 143
IS 2-3
BP 277
EP 284
DI 10.1016/j.schres.2012.12.001
PG 8
WC Psychiatry
SC Psychiatry
GA 072GX
UT WOS:000313659000007
PM 23266067
ER

PT J
AU Adams, JB
   Audhya, T
   McDonough-Means, S
   Rubin, RA
   Quig, D
   Geis, E
   Gehn, E
   Loresto, M
   Mitchell, J
   Atwood, S
   Barnhouse, S
   Lee, W
AF Adams, James B.
   Audhya, Tapan
   McDonough-Means, Sharon
   Rubin, Robert A.
   Quig, David
   Geis, Elizabeth
   Gehn, Eva
   Loresto, Melissa
   Mitchell, Jessica
   Atwood, Sharon
   Barnhouse, Suzanne
   Lee, Wondra
TI Toxicological Status of Children with Autism vs. Neurotypical Children
   and the Association with Autism Severity
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Autism; Toxic metals; Mercury; Lead; Thallium; Tungsten
ID ENVIRONMENTAL MERCURY RELEASE; SPECTRUM DISORDERS; OXIDATIVE STRESS;
   BIOMARKERS; EXCRETION; TOXICITY; HAIR; METHYLATION; EXPOSURE; CHLORIDE
AB This study investigates both the level of toxic metals in children with autism and the possible association of those toxic metals with autism severity. This study involved 55 children with autism ages 5-16 years compared to 44 controls with similar age and gender. The study included measurements of toxic metals in whole blood, red blood cells (RBC), and urine. The autism group had higher levels of lead in RBC (+41 %, p = 0.002) and higher urinary levels of lead (+74 %, p = 0.02), thallium (+77 %, p = 0.0001), tin (+115 %, p = 0.01), and tungsten (+44 %, p = 0.00005). However, the autism group had slightly lower levels of cadmium in whole blood (-19 %, p = 0.003). A stepwise, multiple linear regression analysis found a strong association of levels of toxic metals with variation in the degree of severity of autism for all the severity scales (adjusted R (2) of 0.38-0.47, p < 0.0003). Cadmium (whole blood) and mercury (whole blood and RBC) were the most consistently significant variables. Overall, children with autism have higher average levels of several toxic metals, and levels of several toxic metals are strongly associated with variations in the severity of autism for all three of the autism severity scales investigated.
C1 [Adams, James B.; Geis, Elizabeth; Gehn, Eva; Loresto, Melissa; Atwood, Sharon; Barnhouse, Suzanne; Lee, Wondra] Arizona State Univ, Tempe, AZ 85287 USA.
   [Audhya, Tapan] Hlth Diagnost, S Amboy, NJ USA.
   [McDonough-Means, Sharon] Integrat Dev Pediat, Tucson, AZ USA.
   [Rubin, Robert A.] Whittier Coll, Dept Math, Whittier, CA USA.
   [Quig, David] Doctors Data, St Charles, IL USA.
   [Mitchell, Jessica] SW Coll Naturopath Med, Tempe, AZ USA.
RP Adams, JB (reprint author), Arizona State Univ, POB 876106, Tempe, AZ 85287 USA.
EM jim.adams@asu.edu
FU Autism Research Institute; Legacy Foundation
FX This work was supported by the Autism Research Institute and the Legacy
   Foundation.
CR Abdullah MM, 2012, J AUTISM DEV DISORD, V42, P929, DOI 10.1007/s10803-011-1318-6
   Adams James B, 2009, BMC Clin Pharmacol, V9, P17, DOI 10.1186/1472-6904-9-17
   Adams JB, 2003, C P FALL 2003 DEF AU, P71
   Adams James B, 2009, BMC Clin Pharmacol, V9, P16, DOI 10.1186/1472-6904-9-16
   Adams J. B., 2008, Toxicological and Environmental Chemistry, V90, P739, DOI 10.1080/02772240701699294
   Adams JB, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-34
   Adams JB, 2007, J TOXICOL ENV HEAL A, V70, P1046, DOI 10.1080/15287390601172080
   Adams JB, 2009, J TOXICOL, DOI DOI 10.1155/2009/532640
   Ash MM, 2003, WHEELERS DENT ANATOM
   Bradstreet JJ, 2003, J AM PHYS SURG, V8, P76
   Cohen IL, 2003, J AUTISM DEV DISORD, V33, P31, DOI 10.1023/A:1022226403878
   de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
   Desoto M Catherine, 2007, J Child Neurol, V22, P1308, DOI 10.1177/0883073807307111
   Farmer JG, 2006, ENVIRON GEOCHEM HLTH, V28, P421, DOI 10.1007/s10653-006-9041-5
   Fido A, 2005, AUTISM, V9, P290, DOI 10.1177/1362361305053255
   Geier DA, 2009, J NEUROL SCI, V280, P101, DOI 10.1016/j.jns.2008.08.021
   Geier DA, 2007, J TOXICOL ENV HEAL A, V70, P1723, DOI 10.1080/15287390701457712
   Geier DA, 2010, ACTA NEUROBIOL EXP, V70, P177
   Geier DA, 2006, NEUROTOX RES, V10, P57
   Hertz-Picciotto I, 2010, ENVIRON HEALTH PERSP, V118, P161, DOI 10.1289/ehp.0900736
   Holmes AS, 2003, INT J TOXICOL, V22, P277, DOI 10.1080/10915810390220054
   Ip P, 2004, J CHILD NEUROL, V19, P431
   James SJ, 2009, AM J CLIN NUTR, V89, P425, DOI 10.3945/ajcn.2008.26615
   James SJ, 2004, AM J CLIN NUTR, V80, P1611
   James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366
   Kern JK, 2007, J TOXICOL ENV HEAL A, V70, P1
   KONSTANTAREAS MM, 1987, J AUTISM DEV DISORD, V17, P585, DOI 10.1007/BF01486973
   Nataf R, 2006, TOXICOL APPL PHARM, V214, P99, DOI 10.1016/j.taap.2006.04.008
   Palmer RF, 2006, HEALTH PLACE, V12, P203, DOI 10.1016/j.healthplace.2004.11.005
   Palmer RF, 2009, HEALTH PLACE, V15, P18, DOI 10.1016/j.healthplace.2008.02.001
   Puchyr RF, 1998, BIOL TRACE ELEM RES, V62, P167, DOI 10.1007/BF02783969
   Rimland B., 2000, AUTISM TREATMENT EVA
   ROWLAND IR, 1984, ARCH ENVIRON HEALTH, V39, P401
   ROWLAND IR, 1980, ARCH ENVIRON HEALTH, V35, P155
   ROWLAND IR, 1975, EXPERIENTIA, V31, P1064, DOI 10.1007/BF02326961
   Shandley K, 2011, J TOXICOL ENV HEAL A, V74, P1185, DOI 10.1080/15287394.2011.590097
   Soden SE, 2007, CLIN TOXICOL, V45, P476, DOI 10.1080/15563650701338195
   Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120
   Woods JS, 2010, ENVIRON HEALTH PERSP, V118, P1450, DOI 10.1289/ehp.0901713
   Yorbik O, 2010, BIOL TRACE ELEM RES, V135, P10, DOI 10.1007/s12011-009-8494-7
NR 40
TC 16
Z9 16
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD FEB
PY 2013
VL 151
IS 2
BP 171
EP 180
DI 10.1007/s12011-012-9551-1
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 073IE
UT WOS:000313735900002
PM 23192845
ER

PT J
AU Al-Farsi, YM
   Waly, MI
   Al-Sharbati, MM
   Al-Shafaee, MA
   Al-Farsi, OA
   Al-Khaduri, MM
   Gupta, I
   Ouhtit, A
   Al-Adawi, S
   Al-Said, MF
   Deth, RC
AF Al-Farsi, Yahya M.
   Waly, Mostafa I.
   Al-Sharbati, Marwan M.
   Al-Shafaee, Mohammed A.
   Al-Farsi, Omar A.
   Al-Khaduri, Maha M.
   Gupta, Ishita
   Ouhtit, Allal
   Al-Adawi, Samir
   Al-Said, Mona F.
   Deth, Richard C.
TI Levels of Heavy Metals and Essential Minerals in Hair Samples of
   Children with Autism in Oman: a Case-Control Study
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Autism; Heavy metals; Essential minerals; Hair; Oman; Case-control
ID SPECTRUM DISORDERS; TRACE-ELEMENTS; OXIDATIVE STRESS; GULF-WAR;
   PREVALENCE; MERCURY; DIAGNOSIS; ZINC; MAGNESIUM; SELENIUM
AB Toxic levels of heavy metals and low levels of essential minerals have been suggested to play a critical role in the pathogenesis of autism spectrum disorders (ASD). This study documents the levels of heavy metals and essential minerals in hair samples of children with ASD in Muscat, the urbanized capital of Oman, Muscat. The study included 27 children with ASD and 27 matched non-ASD controls. Parental interviews were held and dietary intake questionnaires completed in conjunction with the collection of hair samples. Analysis of heavy metals and essential minerals was carried out by inductively coupled plasma mass spectrometry. Chi-square analysis and non-parametric Fisher's exact tests were used to assess statistical significance. Children with ASD had significantly higher levels of all 11 analyzed heavy metals in their hair samples (P < 0.05), ranging from 150 to 365 % of control levels. ASD children also had significantly higher levels of essential minerals sulfur, sodium, magnesium, potassium, zinc, and iron, but lower levels of calcium and copper in their hair samples. This study corroborates data from previous studies in different parts of the world indicating the presence of elevated levels of heavy metals and selective depletion of essential minerals in the hair of children with ASD.
C1 [Al-Farsi, Yahya M.; Al-Shafaee, Mohammed A.; Al-Farsi, Omar A.] Sultan Qaboos Univ, Dept Family Med & Publ Hlth, Coll Med & Hlth Sci, Al Khoud 123, Oman.
   [Waly, Mostafa I.] Sultan Qaboos Univ, Dept Nutr & Food Sci, Coll Agr & Marines Sci, Muscat, Oman.
   [Al-Sharbati, Marwan M.; Al-Adawi, Samir] Sultan Qaboos Univ, Dept Behav Med, Coll Med & Hlth Sci, Muscat, Oman.
   [Al-Khaduri, Maha M.] Sultan Qaboos Univ, Dept Obstet & Gynecol, Coll Med & Hlth Sci, Muscat, Oman.
   [Gupta, Ishita; Ouhtit, Allal] Sultan Qaboos Univ, Dept Genet, Coll Med & Hlth Sci, Muscat, Oman.
   [Al-Said, Mona F.] Sultan Qaboos Univ, Dept Early Childhood Educ, Coll Educ, Muscat, Oman.
   [Al-Farsi, Yahya M.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Waly, Mostafa I.] Univ Alexandria, High Inst Publ Hlth, Dept Nutr, Alexandria, Egypt.
   [Deth, Richard C.] Northeastern Univ, Sch Pharm, Bouve Coll Hlth Sci, Boston, MA 02115 USA.
RP Al-Farsi, YM (reprint author), Sultan Qaboos Univ, Dept Family Med & Publ Hlth, Coll Med & Hlth Sci, POB 35, Al Khoud 123, Oman.
EM ymfarsi@squ.edu.om
FU College of Medicine and Health Sciences, Sultan Qaboos University
   [SR/MED/FMCO/11/01, IG/AGR/Food/10/01]
FX This study was supported by the Internal Grant Fund (IG/AGR/Food/10/01)
   and the Strategic Research Fund offered by His Majesty Sultan of Oman
   (SR/MED/FMCO/11/01), College of Medicine and Health Sciences, Sultan
   Qaboos University.
CR Abdullah MM, 2012, J AUTISM DEV DISORD, V42, P929, DOI 10.1007/s10803-011-1318-6
   Adams JB, 2007, J TOXICOL ENV HEAL A, V70, P1046, DOI 10.1080/15287390601172080
   Al-Ayadhi Laila Y, 2005, Neurosciences (Riyadh), V10, P213
   Al-Farsi YM, 2011, RES AUTISM SPECT DIS, V5, P1549, DOI 10.1016/j.rasd.2011.02.018
   Al-Farsi YM, 2011, J AUTISM DEV DISORD, V41, P821, DOI 10.1007/s10803-010-1094-8
   Al-Farsi YM, 2012, NUTRITION IN PRESS
   Al-Yousuf MH, 2000, SCI TOTAL ENVIRON, V256, P87, DOI 10.1016/S0048-9697(99)00363-0
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Bernard S, 2001, MED HYPOTHESES, V56, P462, DOI 10.1054/mehy.2000.1281
   Blaurock-Busch Eleonor, 2011, Maedica (Buchar), V6, P247
   Carneiro MFH, 2011, BIOL TRACE ELEM RES, V143, P815, DOI 10.1007/s12011-010-8947-z
   CDC (Cent. Dis. Control Prev.), 2007, MMWR SURVEILL SUMM, V56, P12
   de Mora S, 2004, MAR POLLUT BULL, V49, P410, DOI 10.1016/j.marpolbul.2004.02.029
   De Palma G, 2012, J AUTISM DEV DISORD, V42, P342, DOI 10.1007/s10803-011-1245-6
   DeSoto MC, 2010, ACTA NEUROBIOL EXP, V70, P165
   Doyle P, 1997, NEW ENGL J MED, V337, P1175
   Eapen V, 2007, J TROP PEDIATRICS, V53, P202, DOI 10.1093/tropej/fml091
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Elsheshtawy E, 2011, MIDDLE E CURR PSYCHI, V18, P6, DOI 10.1097/01.XME.0000392842.64112.64
   EVANS HL, 1975, FED PROC, V34, P1858
   Fido A, 2002, TRACE ELEM ELECTROLY, V19, P205
   Fido A, 2005, AUTISM, V9, P290, DOI 10.1177/1362361305053255
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   Frustaci A, 2012, FREE RADICAL BIO MED, V52, P2128, DOI 10.1016/j.freeradbiomed.2012.03.011
   GENTILE PS, 1983, J AUTISM DEV DISORD, V13, P205, DOI 10.1007/BF01531820
   GESCHWIND SA, 1992, AM J EPIDEMIOL, V135, P1197
   Henson MC, 2004, EXP BIOL MED, V229, P383
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15
   Jung MA, 2008, J KOREAN SOC FOOD SC, V37, P1422
   Kern JK, 2006, J TOXICOL ENV HEAL B, V9, P485, DOI 10.1080/10937400600882079
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
   Lubkowska A, 2009, TRACE ELEM ELECTROLY, V26, P72
   Priya MDL, 2011, BIOL TRACE ELEM RES, V142, P148, DOI 10.1007/s12011-010-8766-2
   Rajab KE, 2000, INT J GYNECOL OBSTET, V68, P139, DOI 10.1016/S0020-7292(99)00195-2
   Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
   Schopler E, 1994, CHILDHOOD AUTISM RAT, P90025
   Semprun-Hernandez N, 2012, TRACE ELEM ELECTROLY, V29, P1, DOI 10.5414/TEX01188
   Soden SE, 2007, CLIN TOXICOL, V45, P476, DOI 10.1080/15563650701338195
   Soliman AT, 1996, J TROP PEDIATRICS, V42, P34, DOI 10.1093/tropej/42.1.34
   Thompson WW, 2007, NEW ENGL J MED, V357, P1281, DOI 10.1056/NEJMoa071434
   VALLEE B L, 1952, Nutr Rev, V10, P65
   WECKER L, 1985, J MENT DEFIC RES, V29, P15
   Zaroff CM, 2012, SOC PSYCH PSYCH EPID, V47, P395, DOI 10.1007/s00127-011-0350-3
NR 46
TC 10
Z9 10
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD FEB
PY 2013
VL 151
IS 2
BP 181
EP 186
DI 10.1007/s12011-012-9553-z
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 073IE
UT WOS:000313735900003
PM 23188679
ER

PT J
AU Mackay, DF
   Smith, GCS
   Dobbie, R
   Cooper, SA
   Pell, JP
AF Mackay, D. F.
   Smith, G. C. S.
   Dobbie, R.
   Cooper, S-A
   Pell, J. P.
TI Obstetric factors and different causes of special educational need:
   retrospective cohort study of 407 503 schoolchildren
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Article
DE Achievement; educational; learning disabilities; low birthweight; fetal
   growth retardation; pregnancy; premature birth
ID LOW-BIRTH-WEIGHT; GESTATIONAL-AGE; SCHOOL PERFORMANCE; CHILDREN BORN;
   INTELLECTUAL-PERFORMANCE; BEHAVIORAL OUTCOMES; PRETERM BIRTH; FOLLOW-UP;
   METAANALYSIS; AUTISM
AB Objective To determine whether relationships with gestational age and birthweight centile vary between specific causes of special educational need (SEN). Design Retrospective cohort study. Setting Scotland. Population A cohort of 407 503 schoolchildren. Methods Polytomous logistic regression was used to examine the risk of each cause of SEN across the spectrum of gestation at delivery and birthweight centile, adjusting for potential confounding factors. Main outcome measures Crude and adjusted odds ratios and confidence intervals. Results Of the 19 821 children with SEN, 557 (2.8%) had sensory impairments, 812 (4.1%) had physical or motor disabilities, 876 (4.4%) had language impairments, 2823 (14.2%) had social, emotional, or behavioural problems, 7018 (35.4%) had intellectual disabilities, 4404 (22.2%) had specific learning difficulties, and 1684 (8.5%) autistic spectrum disorder (ASD). Extreme preterm delivery (at 2427 weeks of gestation) was a strong predictor of sensory (adjusted OR 23.64, 95% CI 12.0346.45), physical or motor (adjusted OR 29.69, 95% CI 17.4950.40), and intellectual (adjusted OR 11.67, 95% CI 8.4616.10) impairments, with dose relationships across the range of gestation. Similarly, birthweight below the third centile was associated with sensory (adjusted OR 2.85, 95% CI 2.043.99), physical or motor (adjusted OR 2.47, 95% CI 1.823.37), and intellectual (adjusted OR 2.67, 95% CI 2.412.96) impairments. Together, gestation and birthweight centile accounted for 24.0% of SEN arising from sensory impairment, 34.3% arising from physical or motor disabilities, and 26.6% arising from intellectual disabilities. Obstetric factors were less strongly associated with specific learning difficulties and social or emotional problems, and there were no significant associations with ASD. Conclusions The association between gestation and birthweight centile and overall risk of SEN is largely driven by very strong associations with sensory, physical or motor impairments, and intellectual impairments.
C1 [Mackay, D. F.; Cooper, S-A; Pell, J. P.] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow G12 8RZ, Lanark, Scotland.
   [Smith, G. C. S.] Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England.
   [Dobbie, R.] NHS Scotland, Informat & Stat Div, Edinburgh, Midlothian, Scotland.
RP Pell, JP (reprint author), Univ Glasgow, Inst Hlth & Wellbeing, 1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.
EM jill.pell@glasgow.ac.uk
RI Smith, Gordon/A-8070-2008
OI Smith, Gordon/0000-0003-2124-0997
CR Aaroudse-Moens CS, 2009, PEDIATRICS, V124, P717
   Anderson PJ, 2008, SEMIN PERINATOL, V32, P51, DOI 10.1053/j.semperi.2007.12.009
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Bhutta AT, 2002, JAMA-J AM MED ASSOC, V288, P728, DOI 10.1001/jama.288.6.728
   Brady AR, 1998, STATA TECHNICAL B, V42, P8
   Davidoff MJ, 2006, SEMIN PERINATOL, V30, P8, DOI 10.1053/j.semperi.2006.01.009
   de Kieviet JF, 2009, JAMA-J AM MED ASSOC, V302, P2235, DOI 10.1001/jama.2009.1708
   Eide MG, 2007, PEDIATR RES, V62, P636
   Foulder-Hughes LA, 2003, DEV MED CHILD NEUROL, V45, P97, DOI 10.1017/S0012162203000197
   HAUSMAN J, 1984, ECONOMETRICA, V52, P1219, DOI 10.2307/1910997
   Information Services Division, 2010, DAT QUAL ASS ASS MAT
   Johnson EO, 2000, BIOL PSYCHIAT, V47, P490, DOI 10.1016/S0006-3223(99)00223-1
   Johnson S, 2007, SEMIN FETAL NEONAT M, V12, P363, DOI 10.1016/j.siny.2007.05.004
   Juul-Dam N., 2001, PEDIATRICS, V107, P1
   Kerr-Wilson CO, 2011, J PUBLIC HL IN PRESS
   Kirkegaard I, 2006, PEDIATRICS, V118, P1600, DOI 10.1542/peds.2005-2700
   LAGERSTROM M, 1991, SCAND J PSYCHOL, V32, P316, DOI 10.1111/j.1467-9450.1991.tb00882.x
   Lundgren EM, 2008, BEST PRACT RES CL EN, V22, P477, DOI 10.1016/j.beem.2008.01.014
   MacKay DF, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000289
   Maimburg RD, 2006, ACTA PSYCHIAT SCAND, V114, P257, DOI 10.1111/j.1600-0447.2006.00805.x
   Morgan BN, 2010, J PEDIAT
   ORNSTEIN M, 1991, ACTA PAEDIATR SCAND, V80, P741, DOI 10.1111/j.1651-2227.1991.tb11943.x
   RECORD RG, 1969, ANN HUM GENET, V33, P71, DOI 10.1111/j.1469-1809.1969.tb01631.x
   RICKARDS AL, 1993, J DEV BEHAV PEDIATR, V14, P363
   Royston P., 2004, STATA J, V4, P227, DOI DOI 10.1037//1082-989X.7.2.147
   WEIR W, 1992, ARCH DIS CHILD, V67, P675
   Van Buuren S, 2000, PGVGZ00038 TNO
   WEISGLASKUPERUS N, 1993, DEV MED CHILD NEUROL, V35, P406
   WIENER G, 1970, J PEDIATR, V76, P694, DOI 10.1016/S0022-3476(70)80286-4
   Yang S, 2010, AM J EPIDEMIOL, V171, P399, DOI 10.1093/aje/kwp413
NR 30
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1470-0328
J9 BJOG-INT J OBSTET GY
JI BJOG
PD FEB
PY 2013
VL 120
IS 3
BP 297
EP 308
DI 10.1111/1471-0528.12071
PG 12
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 073AZ
UT WOS:000313716900006
PM 23189965
ER

PT J
AU Tchaconas, A
   Adesman, A
AF Tchaconas, Alexis
   Adesman, Andrew
TI Autism spectrum disorders: a pediatric overview and update
SO CURRENT OPINION IN PEDIATRICS
LA English
DT Review
DE autism spectrum disorders; cause; diagnosis; pervasive developmental
   disorders
ID PERVASIVE DEVELOPMENTAL DISORDERS; COPY NUMBER VARIATION; ALTERNATIVE
   MEDICINE; YOUNG-CHILDREN; TWIN PAIRS; COMPLEMENTARY; INTERVENTION; RISK;
   ASSOCIATION; PROGRAM
AB Purpose of review
   To provide an updated overview of autism spectrum disorders (ASDs), with particular attention to the pediatrician's role in assessing and managing patients with ASDs.
   Recent findings
   Clinical perspectives on ASDs continue to evolve. The prevalence of ASDs in the United States continues to rise, and pediatricians are being tasked with the responsibility for universal screening. Further changes in its epidemiology will undoubtedly result from anticipated changes in the diagnostic criteria put forth in the upcoming revision to the Diagnostic and Statistical Manual (5th edition). Although there have been considerable advances in identifying a genetic cause in many more cases, the cause remains elusive in most cases. Recent studies of concordant twins suggest there is a stronger environmental component than previously believed. Research suggests earlier diagnosis may be feasible in some cases, and a new treatment approach has been shown to be effective in very young children. Although there have not been any large-scale advances in the medical treatment, some isolated successes have been reported and other promising therapies are now being investigated.
   Summary
   Clinical guidelines for ASDs are evolving, with updated diagnostic criteria expected and revised recommendations for evaluation also imminent. This article provides pediatricians with a clinical overview of ASD - with an emphasis on the clinical considerations relating to screening, evaluation, and management.
C1 [Tchaconas, Alexis] Columbia Univ, New York, NY USA.
   [Adesman, Andrew] Steven & Alexandra Cohen Childrens Med Ctr New Yo, New Hyde Pk, NY USA.
RP Adesman, A (reprint author), Cohen Childrens Med Ctr New York, 1983 Marcus Ave,Suite 130, Lake Success, NY 11042 USA.
EM aadesman@nshs.edu
CR Adams JB, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-34
   Adams JB, 2011, BMC PEDIATR, V11, DOI 10.1186/1471-2431-11-111
   Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
   American Academy of Pediatrics, 2012, AUT TOOLK PHYS FACT
   American Psychiatric Association. DI, 1994, DIAGNOSTIC STAT MANU
   Amminger GP, 2007, BIOL PSYCHIAT, V61, P551, DOI 10.1016/j.biopsych.2006.05.007
   Anagnostou E., 2011, MOL AUTISM, V2, P1
   [Anonymous], 2012, AUTISM SPEAKS WHAT I
   [Anonymous], 2012, MORB MORTAL WKLY REP, V61, P1
   [Anonymous], 2009, THIM VACC QUEST ANSW
   [Anonymous], 2011, CUR LLC REP POS PHAS
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
   Autism Spectrum Disorder, 2011, AUT SPECTR DIS PROP
   Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
   Battaglia A, 2006, AM J MED GENET C, V142C, P3, DOI 10.1002/ajmg.c.30076
   Bertoglio K, 2010, J ALTERN COMPLEM MED, V16, P555, DOI 10.1089/acm.2009.0177
   Buie T., 2010, PEDIATRICS, V125, P1
   Canitano R, 2011, PROG NEURO-PSYCHOPH, V35, P18, DOI 10.1016/j.pnpbp.2010.10.015
   Casenhiser DM, 2011, AUTISM, V1, P1
   Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950
   Curemark, 2009, PHAS 3 RAND DOUBL BL
   Davis TN, 2013, RES AUTISM SPECT DIS, V7, P49, DOI 10.1016/j.rasd.2012.06.005
   Dawson G., 2009, PEDIATRICS, V125, P17
   Dembosky A, 2010, NY TIMES
   Fernandez T, 2008, AM J HUM GENET, V82, P1385, DOI 10.1016/j.ajhg.2008.04.021
   Filipek PA, 2000, NEUROLOGY, V55, P468
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Fountain C., 2012, PEDIATRICS, V129, P1
   Gadow K, 1986, CHILDREN MEDICATION, V1
   Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
   Ghanizadeh Ahmad, 2012, Med Gas Res, V2, P13, DOI 10.1186/2045-9912-2-13
   Godlee F, 2011, BMJ-BRIT MED J, V342, P7452
   Goines PE, 2013, NEUROTOXICOL TERATOL, V36, P67, DOI 10.1016/j.ntt.2012.07.006
   Greenspan S. I., 1997, J DEV LEARNING DISOR, V1, P87
   Gundacker C, 2002, PEDIATRICS, V110, P873, DOI 10.1542/peds.110.5.873
   Gupta VB, 2010, J DEV BEHAV PEDIATR, V31, P343, DOI 10.1097/DBP.0b013e3181d6b6e4
   Gutstein S, 2002, RELATIONSHIP DEV INT
   Gutstein SE, 2007, AUTISM, V11, P397, DOI 10.1177/1362361307079603
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hanson E, 2007, J AUTISM DEV DISORD, V37, P628, DOI 10.1007/s10803-006-0192-0
   Hardan AY, 2012, BIOL PSYCHIAT, V71, P956, DOI 10.1016/j.biopsych.2012.01.014
   Henderson C, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004218
   Honda H, 2005, J CHILD PSYCHOL PSYC, V46, P572, DOI 10.1111/j.1469-7610.2005.01425.x
   Hsiao EY, 2012, P NATL ACAD SCI USA, V109, P12776, DOI 10.1073/pnas.1202556109
   Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
   Huffman LC, 2011, J DEV BEHAV PEDIATR, V32, P56, DOI 10.1097/DBP.0b013e3182040acf
   Jabr F., 2012, SCI AM
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Kearney HM, 2011, GENET MED, V13, P680, DOI 10.1097/GIM.0b013e3182217a3a
   Knivsberg AM, 2002, NUTR NEUROSCI, V5, P251, DOI 10.1080/10281450290028945
   Lovaas O. I., 2003, TEACHING INDIVIDUALS
   Maestrini E, 2010, MOL PSYCHIATR, V15, P954, DOI 10.1038/mp.2009.34
   Manning M, 2010, GENET MED, V12, P742, DOI 10.1097/GIM.0b013e3181f8baad
   Mefford HC, 2012, N ENGL J MED
   Mendelsohn NJ, 2008, SEMIN PEDIATR NEUROL, V15, P27, DOI 10.1016/j.spen.2008.01.005
   Mesibov GB, 2005, TEACCH APPROACH AUTI
   Moser Charlotte A., 2009, PEDIATRICS, V123, P164
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   National Autism Center, 2009, NAT STAND PROJ ADDR
   Novarino G, 2012, SCIENCE, V338, P394, DOI 10.1126/science.1224631
   Nye C, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003497
   Ozonoff S, 1998, J AUTISM DEV DISORD, V28, P25, DOI 10.1023/A:1026006818310
   Pajareya K, 2011, AUTISM, V15, P563, DOI 10.1177/1362361310386502
   Peart K, 2012, YALE NEWS       0519
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Posey DJ, 2007, BIOL PSYCHIAT, V61, P538, DOI 10.1016/j.biopsych.2006.09.028
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Rogers S. J., 2012, EARLY START YOUR CHI
   Saunders CJ, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004041
   Schendel D, 2008, PEDIATRICS, V121, P1155, DOI 10.1542/peds.2007-1049
   Schreibman L., 2005, HDB AUTISM PERVASIVE, P882
   Shen Y, 2010, PEDIATRICS, V125, P727
   Skafidas E., 2012, MOL PSYCHIAT
   Solomon R, 2007, AUTISM, V11, P205, DOI 10.1177/1362361307076842
   Sowell ER, 2012, AM J PSYCHIAT, V169, P551, DOI 10.1176/appi.ajp.2012.12030397
   Spitzer R, 1980, DIAGNOSTIC STAT MANU
   Stoltenberg C, 2010, MOL PSYCHIATR, V15, P676, DOI 10.1038/mp.2009.143
   Sykes NH, 2009, EUR J HUM GENET, V17, P1347, DOI 10.1038/ejhg.2009.47
   Szatmari P, 2011, ARCH GEN PSYCHIAT, V68, P1091, DOI 10.1001/archgenpsychiatry.2011.99
   Turner-Brown LM, 2012, AUTISM
   Wakefield AJ, 1998, LANCET, V351, P637, DOI 10.1016/S0140-6736(97)11096-0
   Weiss MJ, 2001, BEHAV MODIF, V25, P785, DOI 10.1177/0145445501255007
   Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447
   Wong HHL, 2006, J AUTISM DEV DISORD, V36, P901, DOI 10.1007/s10803-006-0131-0
NR 86
TC 8
Z9 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1040-8703
J9 CURR OPIN PEDIATR
JI CURR. OPIN. PEDIATR.
PD FEB
PY 2013
VL 25
IS 1
BP 130
EP 144
DI 10.1097/MOP.0b013e32835c2b70
PG 15
WC Pediatrics
SC Pediatrics
GA 069DC
UT WOS:000313414400019
PM 23274432
ER

PT J
AU Payne, JM
AF Payne, Jonathan M.
TI Autism spectrum disorder symptomatology in children with
   neurofibromatosis type 1
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Editorial Material
C1 [Payne, Jonathan M.] Childrens Hosp Westmead, Inst Neurosci & Muscle Res, Sydney, NSW, Australia.
   [Payne, Jonathan M.] Univ Sydney, Fac Med, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia.
RP Payne, JM (reprint author), Childrens Hosp Westmead, Inst Neurosci & Muscle Res, Sydney, NSW, Australia.
CR Aldridge FJ, 2012, J AUTISM DEV DISORD, V42, P294, DOI 10.1007/s10803-011-1242-9
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Duarte JV, 2012, HUM BRAIN MAPP, DOI [10.1002/hbm.22161, DOI 10.1002/HBM.22161]
   Garg S, 2013, DEV MED CHILD NEUROL, V55, P139, DOI 10.1111/dmcn.12043
   Mbarek O, 1999, AM J MED GENET, V88, P729, DOI 10.1002/(SICI)1096-8628(19991215)88:6<729::AID-AJMG26>3.0.CO;2-Q
   Nava C, 2007, J MED GENET, V44, P763, DOI 10.1136/jmg.2007.050450
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006
   Walsh KS, 2013, DEV MED CHILD NEUROL, V55, P131, DOI 10.1111/dmcn.12038
NR 9
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD FEB
PY 2013
VL 55
IS 2
BP 100
EP 101
DI 10.1111/dmcn.12075
PG 2
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 073FT
UT WOS:000313729600002
PM 23320572
ER

PT J
AU Hagerman, RJ
AF Hagerman, Randi J.
TI Epilepsy drives autism in neurodevelopmental disorders
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Editorial Material
ID FRAGILE-X-SYNDROME; MINOCYCLINE
C1 [Hagerman, Randi J.] Univ Calif Davis Hlth Syst, Med Invest Neurodev Disorders MIND Inst, Sacramento, CA USA.
   [Hagerman, Randi J.] Univ Calif Davis Hlth Syst, Dept Pediat, Sacramento, CA USA.
RP Hagerman, RJ (reprint author), Univ Calif Davis Hlth Syst, Med Invest Neurodev Disorders MIND Inst, Sacramento, CA USA.
CR Bernard P, 2012, 42 ANN M SOC NEUR NE
   Berry-Kravis E, 2010, AJIDD-AM J INTELLECT, V115, P461, DOI [10.1352/1944-7558-115.6.461, 10.1352/194475581156461]
   Berry-Kravis EM, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004214
   Bilousova TV, 2009, J MED GENET, V46, P94, DOI 10.1136/jmg.2008.061796
   Chen YC, 2010, HUM MOL GENET, V19, P196, DOI 10.1093/hmg/ddp479
   Chonchaiya W, 2012, HUM GENET, V131, P581, DOI 10.1007/s00439-011-1106-6
   Fatemi SH, 2011, NEUROPHARMACOLOGY, V60, P1221, DOI 10.1016/j.neuropharm.2010.11.011
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Jacquemont S, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001708
   Paribello C, 2010, BMC NEUROL, V10, DOI 10.1186/1471-2377-10-91
   Qureshi IA, 2010, NEUROBIOL DIS, V39, P53, DOI 10.1016/j.nbd.2010.02.005
   Van Eeghen AM, 2013, DEV MED CHILD NEUROL, V55, P146, DOI 10.1111/dmcn.12044
   Wilczynski GM, 2008, J CELL BIOL, V180, P1021, DOI 10.1083/jcb.200708213
NR 13
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD FEB
PY 2013
VL 55
IS 2
BP 101
EP 102
DI 10.1111/dmcn.12071
PG 2
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 073FT
UT WOS:000313729600003
PM 23320573
ER

PT J
AU Walsh, KS
   Velez, JI
   Kardel, PG
   Imas, DM
   Muenke, M
   Packer, RJ
   Castellanos, FX
   Acosta, MT
AF Walsh, Karin S.
   Velez, Jorge I.
   Kardel, Peter G.
   Imas, Daniel M.
   Muenke, Maximilian
   Packer, Roger J.
   Castellanos, Francisco X.
   Acosta, Maria T.
TI Symptomatology of autism spectrum disorder in a population with
   neurofibromatosis type 1
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT-HYPERACTIVITY
   DISORDER; COGNITIVE DEFICITS; CHILDREN; ADHD; ASSOCIATION; BEHAVIOR;
   SUSCEPTIBILITY; SUBTYPES; GENE
AB Aim Difficulties in neurocognition and social interaction are the most prominent causes of morbidity and long-term disability in children with neurofibromatosis type 1 (NF1). Symptoms of attention-deficithyperactivity disorder (ADHD) have also been extensively recognized in NF1. However, systematic evaluation of symptoms of autism spectrum disorder (ASD) in children with NF1 has been limited. Method We present a retrospective, cross-sectional study of the prevalence of symptoms of ASD and ADHD and their relationship in a consecutive series of 66 patients from our NF1 clinic. The Social Responsiveness Scale and the Vanderbilt ADHD Diagnostic Parent Rating Scale were used to assess symptoms of ASD and ADHD. Results Sixty-six participants (42 males, 24 females) were included in this study. Mean age at assessment was 10 years 11 months (SD 5y 4mo). Forty percent of our NF1 sample had raised symptom levels reaching clinical significance on the Social Responsiveness Scale (T = 60), and 14% reached levels consistent with those seen in children with ASDs (T = 75). These raised levels were not explained by NF1 disease severity or externalizing/internalizing behavioral disorders. There was a statistically significant relationship between symptoms of ADHD and ASD (?2=9.11, df=1, p=0.003, f=0.56). Particularly salient were the relationships between attention and hyperactivity deficits, with impairments in social awareness and social motivation. Interpretation We found that symptoms of ASD in our NF1 population were raised, consistent with previous reports. Further characterization of the specific ASD symptoms and their impact on daily function is fundamental to the development and implementation of effective interventions in this population, which will probably include a combination of medical and behavioral approaches.
C1 [Walsh, Karin S.; Kardel, Peter G.; Imas, Daniel M.; Packer, Roger J.; Acosta, Maria T.] Jennifer & Daniel Gilbert Neurofibromatosis Inst, Washington, DC 20010 USA.
   [Walsh, Karin S.; Kardel, Peter G.; Imas, Daniel M.; Packer, Roger J.; Acosta, Maria T.] Childrens Natl Med Ctr, Ctr Neurosci & Behav Med, Washington, DC 20010 USA.
   [Velez, Jorge I.; Muenke, Maximilian; Acosta, Maria T.] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA.
   [Castellanos, Francisco X.] NYU, Phyllis Green & Randolph Cowen Inst Pediat Neuros, Langone Med Ctr, New York, NY USA.
   [Castellanos, Francisco X.] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
RP Acosta, MT (reprint author), Jennifer & Daniel Gilbert Neurofibromatosis Inst, 111 Michigan Ave NW, Washington, DC 20010 USA.
EM macosta@childrensnational.org
CR Acosta MT, 2008, J AM ACAD CHILD PSY, V47, P797, DOI 10.1097/CHI.0b013e318173f70b
   Acosta MT, 2006, CURR NEUROL NEUROSCI, V6, P136, DOI 10.1007/s11910-996-0036-5
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Arcos-Burgos M, 2010, MOL PSYCHIATR, V15, P1053, DOI 10.1038/mp.2010.6
   Barton B, 2004, DEV MED CHILD NEUROL, V46, P553, DOI 10.1017/S0012162204000921
   Benjamini Y, 1995, JR STAT SOC B, V57, P389
   Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
   Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Coudé François X, 2007, J Atten Disord, V11, P101, DOI 10.1177/1087054707299398
   Grzadzinski R, 2011, J AUTISM DEV DISORD, V41, P1178, DOI 10.1007/s10803-010-1135-3
   Gutmann DH, 1997, JAMA-J AM MED ASSOC, V278, P51, DOI 10.1001/jama.278.1.51
   Hoza B, 2007, J PEDIATR PSYCHOL, V32, P655, DOI 10.1093/jpepsy/jsm024
   Huijbregts SCJ, 2011, BEHAV GENET, V41, P430, DOI 10.1007/s10519-010-9430-5
   Hyman SL, 2005, NEUROLOGY, V65, P1037, DOI 10.1212/01.wnl.0000179303.72345.ce
   Hyman SL, 2006, DEV MED CHILD NEUROL, V48, P973, DOI 10.1017/S0012162206002131
   Jain M, 2007, BIOL PSYCHIAT, V61, P1329, DOI 10.1016/j.biopsych.2006.06.026
   Johnson NS, 1999, J PEDIATR-US, V134, P767, DOI 10.1016/S0022-3476(99)70296-9
   Marui T, 2004, AM J MED GENET B, V131B, P43, DOI 10.1002/ajmg.b.20119
   Mbarek O, 1999, AM J MED GENET, V88, P729, DOI 10.1002/(SICI)1096-8628(19991215)88:6<729::AID-AJMG26>3.0.CO;2-Q
   McQuade JD, 2008, DEV DISABIL RES REV, V14, P320, DOI 10.1002/ddrr.35
   North K, 2002, J CHILD NEUROL, V17, P605, DOI 10.1177/088307380201700811
   Palacio JD, 2004, J AM ACAD CHILD PSY, V43, P1506, DOI 10.1097/01.chi.0000142279.79805.de
   Payne JM, 2011, CHILD NEUROPSYCHOL, V17, P313, DOI 10.1080/09297049.2010.542746
   Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
   Solanto MV, 2009, J ATTEN DISORD, V13, P27, DOI 10.1177/1087054708320403
   Suzuki R., PVCLUST HIERARCHICAL
   Wehmeier PM, 2010, J ADOLESCENT HEALTH, V46, P209, DOI 10.1016/j.jadohealth.2009.09.009
   Williams PG, 1998, J AUTISM DEV DISORD, V28, P567, DOI 10.1023/A:1026012414193
   Wolraich ML, 2003, J PEDIATR PSYCHOL, V28, P559, DOI 10.1093/jpepsy/jsg046
NR 30
TC 16
Z9 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD FEB
PY 2013
VL 55
IS 2
BP 131
EP 138
DI 10.1111/dmcn.12038
PG 8
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 073FT
UT WOS:000313729600011
PM 23163951
ER

PT J
AU Garg, S
   Lehtonen, A
   Huson, SM
   Emsley, R
   Trump, D
   Evans, DG
   Green, J
AF Garg, Shruti
   Lehtonen, Annukka
   Huson, Susan M.
   Emsley, Richard
   Trump, Dorothy
   Evans, D. Gareth
   Green, Jonathan
TI Autism and other psychiatric comorbidity in neurofibromatosis type 1:
   evidence from a population-based study
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Article
ID DIFFICULTIES QUESTIONNAIRE; INTELLECTUAL DISABILITY; GENERAL-POPULATION;
   EMOTIONAL-PROBLEMS; CHILDREN; DISORDERS; PREVALENCE; ADOLESCENTS;
   SAMPLE; NF1
AB Aim To investigate psychopathology in children with neurofibromatosis type 1 (NF1), particularly the prevalence of autism spectrum disorder (ASD) and attention-deficithyperactivity disorder (ADHD) symptomatology, using a population-based sampling approach. Method Standard questionnaire screen reports were analysed for ASD (Social Responsiveness Scale, SRS), ADHD (Conners Parent Rating Scale- Revised, CPRS-R), and other psychiatric morbidity (Strengths and Difficulties Questionnaire, SDQ) from parents and teachers of children aged from 4 to 16 years (112 females, 95 males) on the UK North West Regional Genetic Service register for NF1. Results Parental response rate was 52.7% (109/207 children; 59 females, 50 males, mean age 9y 11mo, SD 3y 3mo). The SRS showed that in 29.4% (32/109) of children, autism was in the severe, clinical range (T-score>75) and in 26.6% (29/109) in the mild to moderate range (T-score 6075). CPRS-R scores showed that in 53.8% (57/106) of children autism was in the clinical ADHD range (ADHD index T-score>65). Based on their scores on the SDQ total difficulties scale, 41.5% (44/106) of children were in the abnormal range and 14.2% (15/106) were in the borderline range. Twenty-five per cent (26/104) of children met criteria for both clinical autism and ADHD. Interpretation This representative population-based sample of children with NF1 indicates a high prevalence of ASD symptoms associated with NF1 as well as substantial co-occurrence with ADHD symptoms. The findings clarify the psychopathology of NF1 and show the disorder as a potentially important single-gene cause for autism symptoms.
C1 [Garg, Shruti; Green, Jonathan] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester M13 9PL, Lancs, England.
   [Lehtonen, Annukka; Huson, Susan M.; Trump, Dorothy; Evans, D. Gareth] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
   [Emsley, Richard] Univ Manchester, Inst Populat Hlth, Ctr Biostat, Manchester M13 9PL, Lancs, England.
   [Green, Jonathan] Manchester Childrens Hosp, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
RP Green, J (reprint author), Univ Manchester, Inst Brain Behav & Mental Hlth, Room 4-308,Jean McFarlane Bldg,Oxford Rd, Manchester M13 9PL, Lancs, England.
EM jonathan.green@manchester.ac.uk
FU Manchester Biomedical Research Centre through a Clinical Research
   Fellowship
FX The authors thank Steve Roberts for early advice on study design, Marco
   Heise for database support, and Karen Tricker for administrative
   support. The study was funded by the Manchester Biomedical Research
   Centre through a Clinical Research Fellowship to SG and grant funding to
   AL.
CR ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Angold A, 1999, J CHILD PSYCHOL PSYC, V40, P57, DOI 10.1017/S0021963098003448
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Barton B, 2004, DEV MED CHILD NEUROL, V46, P553, DOI 10.1017/S0012162204000921
   BERKSON J, 1946, BIOMETRICS BULL, V2, P47, DOI 10.2307/3002000
   Brereton AV, 2006, J AUTISM DEV DISORD, V36, P863, DOI 10.1007/s10803-006-0125-y
   CARON C, 1991, J CHILD PSYCHOL PSYC, V32, P1063, DOI 10.1111/j.1469-7610.1991.tb00350.x
   Conners K., 1998, J ABNORMAL CHILD PSY, V26, P257, DOI DOI 10.1023/A:1022602400621
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Constantino JN, 2002, SOCIAL RESPONSIVENES
   Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
   Coudé François X, 2007, J Atten Disord, V11, P101, DOI 10.1177/1087054707299398
   Dilts CV, 1996, J DEV BEHAV PEDIATR, V17, P229
   DUFORT GG, 1993, J NERV MENT DIS, V181, P467, DOI 10.1097/00005053-199308000-00001
   Evans DG, 2010, AM J MED GENET A, V152A, P327, DOI 10.1002/ajmg.a.33139
   Evans DGR, 2011, EUR J HUM GENET, V19, P1187, DOI 10.1038/ejhg.2011.113
   Fombonne E, 1997, J AM ACAD CHILD PSY, V36, P1561, DOI 10.1016/S0890-8567(09)66566-7
   Ford T., 2003, CLIN CHILD PSYCHOL P, V8, P37, DOI 10.1177/1359104503008001006
   GAFFNEY GR, 1987, J AUTISM DEV DISORD, V17, P433, DOI 10.1007/BF01487072
   GILLBERG C, 1984, J AUTISM DEV DISORD, V14, P1, DOI 10.1007/BF02408551
   Goodman R, 2000, BRIT J PSYCHIAT, V177, P534, DOI 10.1192/bjp.177.6.534
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Hofman K, 1994, J PEDIAT, V128, pS1
   Huijbregts S, 2010, DEV MED CHILD NEUROL, V52, P620, DOI 10.1111/j.1469-8749.2010.03639.x
   Huijbregts SCJ, 2011, BEHAV GENET, V41, P430, DOI 10.1007/s10519-010-9430-5
   Hyman SL, 2005, NEUROLOGY, V65, P1037, DOI 10.1212/01.wnl.0000179303.72345.ce
   International Molecular genetic Study of Autism Consortium (IMG-SAC), 2001, AM J HUMAM GENETICS, V69, P570
   Johnson H, 2005, DEV MED CHILD NEUROL, V47, P237, DOI 10.1017/S0012162205000460
   Johnson NS, 1999, J PEDIATR-US, V134, P767, DOI 10.1016/S0022-3476(99)70296-9
   Kadesjo B, 2001, J CHILD PSYCHOL PSYC, V42, P487, DOI 10.1017/S0021963001007090
   La Malfa G, 2004, J INTELL DISABIL RES, V48, P262, DOI 10.1111/j.1365-2788.2003.00567.x
   Marui T, 2004, AM J MED GENET B, V131B, P43, DOI 10.1002/ajmg.b.20119
   Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
   Mautner VF, 2002, DEV MED CHILD NEUROL, V44, P164, DOI 10.1017/S0012162201001876
   Mbarek O, 1999, AM J MED GENET, V88, P729, DOI 10.1002/(SICI)1096-8628(19991215)88:6<729::AID-AJMG26>3.0.CO;2-Q
   Mouridsen S E, 1992, Acta Paedopsychiatr, V55, P15
   National Institutes of Health Consensus Development Conference, 1988, ARCH NEUROL-CHICAGO, V45, P575
   Noble M., 2008, ENGLISH INDICES DEPR
   Noll RB, 2007, AM J MED GENET A, V143A, P2261, DOI 10.1002/ajmg.a.31923
   Riccardi V, 1992, NEUROFIBROMATOSIS PH
   SAMUELSSON B, 1989, Neurofibromatosis, V2, P84
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   World Health Organization, 1993, MENT DIS GLOSS GUID
NR 44
TC 20
Z9 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD FEB
PY 2013
VL 55
IS 2
BP 139
EP 145
DI 10.1111/dmcn.12043
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 073FT
UT WOS:000313729600012
PM 23163236
ER

PT J
AU Van Eeghen, AM
   Pulsifer, MB
   Merker, VL
   Neumeyer, AM
   Van Eeghen, EE
   Thibert, RL
   Cole, AJ
   Leigh, FA
   Plotkin, SR
   Thiele, EA
AF Van Eeghen, Agnies M.
   Pulsifer, Margaret B.
   Merker, Vanessa L.
   Neumeyer, Ann M.
   Van Eeghen, Elmer E.
   Thibert, Ronald L.
   Cole, Andrew J.
   Leigh, Fawn A.
   Plotkin, Scott R.
   Thiele, Elizabeth A.
TI Understanding relationships between autism, intelligence, and epilepsy:
   a cross-disorder approach
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Article
ID TUBEROUS SCLEROSIS COMPLEX; PERVASIVE DEVELOPMENTAL DISORDERS; INFANTILE
   SPASMS; DOWN-SYNDROME; FRAGILE-X; CHILDREN; SPECTRUM; INDIVIDUALS;
   DEFINITION; MUTATIONS
AB Aim As relationships between autistic traits, epilepsy, and cognitive functioning remain poorly understood, these associations were explored in the biologically related disorders tuberous sclerosis complex (TSC), neurofibromatosis type 1 (NF1), and epilepsy. Method The Social Responsiveness Scale (SRS), a quantitative measure of autistic traits, was distributed to caregivers or companions of patients with TSC, NF1, and childhood-onset epilepsy of unknown cause (EUC), and these results were compared with SRS data from individuals with idiopathic autism spectrum disorders (ASDs) and their unaffected siblings. Scores and trait profiles of autistic features were compared with cognitive outcomes, epilepsy variables, and genotype. Results A total of 180 SRS questionnaires were completed in the TSC, NF1, and EUC outpatient clinics at the Massachusetts General Hospital (90 females, 90 males; mean age 21y, range 463y), and SRS data from 210 patients with ASD recruited from an autism research collaboration (167 males, 43 females; mean age 9y, range 422y) and 130 unaffected siblings were available. Regression models showed a significant association between SRS scores and intelligence outcomes (p<0.001) and various seizure variables (p<0.02), but not with a specific underlying disorder or genotype. The level of autistic features was strongly associated with intelligence outcomes in patients with TSC and epilepsy (p<0.01); in patients with NF1 these relationships were weaker (p=0.25). For all study groups, autistic trait subdomains covaried with neurocognitive comorbidity, with endophenotypes similar to that of idiopathic autism. Interpretation Our data show that in TSC and childhood-onset epilepsy, the severity and phenotype of autistic features are inextricably linked with intelligence and epilepsy outcomes. Such relationships were weaker for individuals with NF1. Findings suggest that ASDs are not specific in these conditions.
C1 [Van Eeghen, Agnies M.; Van Eeghen, Elmer E.; Thiele, Elizabeth A.] Massachusetts Gen Hosp, Dept Neurol, Carol & James Herscot Ctr Tuberous Sclerosis Comp, Boston, MA 02114 USA.
   [Van Eeghen, Agnies M.] Erasmus MC, Expertise Ctr Neurodev Disorders, ENCORE, Dept Neurosci, Rotterdam, Netherlands.
   [Pulsifer, Margaret B.] Massachusetts Gen Hosp, Dept Psychiat, Psychol Assessment Ctr, Boston, MA 02114 USA.
   [Merker, Vanessa L.; Leigh, Fawn A.; Plotkin, Scott R.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA.
   [Neumeyer, Ann M.] Massachusetts Gen Hosp, Dept Neurol, Lurie Ctr Autism, Boston, MA 02114 USA.
   [Thibert, Ronald L.] Massachusetts Gen Hosp, Dept Neurol, Pediat Epilepsy Serv, Boston, MA 02114 USA.
   [Cole, Andrew J.] Massachusetts Gen Hosp, Dept Neurol, Epilepsy Serv, Boston, MA 02114 USA.
RP Thiele, EA (reprint author), Carol & James Herscot Ctr Tuberous Sclerosis, 175 Cambridge St,Suite 340, Boston, MA 02114 USA.
EM ethiele@partners.org
FU Herscot Center for Tuberous Sclerosis Complex; NIH/NINDS [P01 NS024279]
FX We are grateful to the families and individuals who agreed to
   participate in this study and the Autism Consortium for their valuable
   time and effort. We are grateful to the Autism Consortium for access to
   the data analyzed here, and for the support from Christine Ferrone and
   Roksana Sasanfar for assisting with the Autism Consortium data
   collection. We thank Zaida Ortega, Christina Anagnos, Jill Beamon, and
   Joseph Nimon for assisting with distribution and scoring of the
   questionnaires. Lastly, we are grateful to the MGH Department of
   Biostatistics for assistance with statistical analysis. This study was
   sponsored by the Herscot Center for Tuberous Sclerosis Complex, and
   NIH/NINDS P01 NS024279.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
   Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   Berg AT, 2001, J CHILD NEUROL, V26, P540
   Berg AT, 2012, EPILEPSY BEHAV, V23, P193, DOI 10.1016/j.yebeh.2012.01.015
   Berg AT, 2011, EPILEPSY BEHAV, V22, P336, DOI 10.1016/j.yebeh.2011.07.014
   Carcani-Rathwell I, 2006, J CHILD PSYCHOL PSYC, V47, P573, DOI 10.1111/j.1469-7610.2005.01565.x
   Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
   Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
   Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Cormack F, 2007, EPILEPSIA, V48, P201, DOI 10.1111/j.1528-1167.2006.00904.x
   Cui YJ, 2008, CELL, V135, P549, DOI 10.1016/j.cell.2008.09.060
   Descheemaeker MJ, 2004, AM J MED GENET A, V131A, P325, DOI 10.1002/ajmg.a.30346
   Ehninger D, 2009, NAT MED, V15, P849, DOI 10.1038/nm0809-849
   Eisermann MM, 2003, EPILEPSY RES, V55, P21, DOI 10.1016/S0920-1211(30)00088-3
   Fombonne E, 1997, J AM ACAD CHILD PSY, V36, P1561, DOI 10.1016/S0890-8567(09)66566-7
   Garcia-Nonell C, 2008, AM J MED GENET A, V146A, P1911, DOI 10.1002/ajmg.a.32290
   Goh S, 2005, NEUROLOGY, V65, P235, DOI 10.1212/01.wnl.0000168908.78118.99
   Goto J, 2011, P NATL ACAD SCI USA, V108, pE1070, DOI 10.1073/pnas.1106454108
   Granader YE, 2010, EPILEPSY BEHAV, V18, P262, DOI 10.1016/j.yebeh.2010.04.010
   Gutierrez GC, 1998, J AUTISM DEV DISORD, V28, P97, DOI 10.1023/A:1026032413811
   Hagerman RJ, 2006, J DEV BEHAV PEDIATR, V27, P63, DOI 10.1097/00004703-200602000-00012
   Hermann B, 2010, EPILEPSY BEHAV, V17, P1, DOI 10.1016/j.yebeh.2009.10.019
   Jackson M.J., 2005, J NEUROL NEUROSUR S1, V76, P45
   Kanner L, 1943, NERV CHILD, V2, P217
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Kwan P, 2010, EPILEPSIA, V51, P1069, DOI 10.1111/j.1528-1167.2009.02397.x
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mautner VF, 2010, J MED GENET, V47, P623, DOI 10.1136/jmg.2009.075937
   McDaniel SS, 2011, NEUROSCI LETT, V497, P231, DOI 10.1016/j.neulet.2011.02.037
   Miles JH, 2005, AM J MED GENET A, V135A, P171, DOI 10.1002/ajmg.a.30590
   Molloy CA, 2009, J INTELL DISABIL RES, V53, P143, DOI 10.1111/j.1365-2788.2008.01138.x
   Numis AL, 2011, NEUROLOGY, V76, P981, DOI 10.1212/WNL.0b013e3182104347
   Payne JM, 2010, J NEUROL NEUROSUR PS, V81, P304, DOI 10.1136/jnnp.2009.179630
   Plank SM, 2001, AM J MED GENET, V105, P404, DOI 10.1002/ajmg.1432
   Pulsifer MB, 2007, EPILEPSY BEHAV, V10, P402, DOI 10.1016/j.yebeh.2007.02.004
   Qin W, 2010, BRAIN PATHOL, V20, P1096, DOI 10.1111/j.1750-3639.2010.00416.x
   Rasmussen P, 2001, DEV MED CHILD NEUROL, V43, P750, DOI 10.1017/S0012162201001372
   Ridler K, 2007, CEREB CORTEX, V17, P261, DOI 10.1093/cercor/bhj144
   Sevin JA, 2003, CHILD PSYCHIAT HUM D, V34, P147, DOI 10.1023/A:1027346108645
   Talos DM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035885
   Trillingsgaard A, 2004, AUTISM, V8, P163, DOI 10.1177/1362361304042720
   van Eeghen AM, 2012, EUR J HUM GENET, V20, P510, DOI 10.1038/ejhg.2011.241
NR 46
TC 15
Z9 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD FEB
PY 2013
VL 55
IS 2
BP 146
EP 153
DI 10.1111/dmcn.12044
PG 8
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 073FT
UT WOS:000313729600013
PM 23205844
ER

PT J
AU Sharma, JR
   Arieff, Z
   Gameeldien, H
   Davids, M
   Kaur, M
   van der Merwe, L
AF Sharma, Jyoti Rajan
   Arieff, Zainunisha
   Gameeldien, Hajirah
   Davids, Muneera
   Kaur, Mandeep
   van der Merwe, Lize
TI Association Analysis of Two Single-Nucleotide Polymorphisms of the RELN
   Gene with Autism in the South African Population
SO GENETIC TESTING AND MOLECULAR BIOMARKERS
LA English
DT Article
ID CHINESE HAN POPULATION; REELIN GENE; SPECTRUM DISORDER; NEUROANATOMICAL
   ABNORMALITIES; BRAIN-DEVELOPMENT; BIPOLAR DISORDER; CEREBRAL-CORTEX;
   SCHIZOPHRENIA; EXPRESSION; SUSCEPTIBILITY
AB Background: Autism (MIM209850) is a neurodevelopmental disorder characterized by a triad of impairments, namely impairment in social interaction, impaired communication skills, and restrictive and repetitive behavior. A number of family and twin studies have demonstrated that genetic factors play a pivotal role in the etiology of autistic disorder. Various reports of reduced levels of reelin protein in the brain and plasma in autistic patients highlighted the role of the reelin gene (RELN) in autism. There is no such published study on the South African (SA) population. Aims: The aim of the present study was to find the genetic association of intronic rs736707 and exonic rs362691 (single-nucleotide polymorphisms [SNPs] of the RELN gene) with autism in a SA population. Methods: Genomic DNA was isolated from cheek cell swabs from autistic (136) as well as control (208) subjects. The TaqMan (R) Real-Time polymerase chain reaction and genotyping assay was utilized to determine the genotypes. Results: A significant association of SNP rs736707, but not for SNP rs362691, with autism in the SA population is observed. Conclusion: There might be a possible role of RELN in autism, especially for SA populations. The present study represents the first report on genetic association studies on the RELN gene in the SA population.
C1 [Sharma, Jyoti Rajan; Arieff, Zainunisha; Gameeldien, Hajirah; Davids, Muneera; Kaur, Mandeep] Univ Western Cape, Fac Nat Sci, Dept Biotechnol, ZA-7535 Bellville, South Africa.
   [Kaur, Mandeep] King Abdullah Univ Sci & Technol, Computat Biosci Res Ctr, Thuwal, Saudi Arabia.
   [van der Merwe, Lize] MRC, Biostat Unit, Tygerberg, South Africa.
   [van der Merwe, Lize] Univ Western Cape, Dept Stat, Cape Town, South Africa.
RP Arieff, Z (reprint author), Univ Western Cape, Fac Nat Sci, Dept Biotechnol, Private Bag X17, ZA-7535 Bellville, South Africa.
EM zarieff@uwc.ac.za
FU National Research Foundation, South Africa [TTK2008050600011]; Autism
   South Africa; University of the Western Cape
FX We would like to thank the National Research Foundation, South Africa
   (Thuthuka grant TTK2008050600011), Autism South Africa, and the
   University of the Western Cape, for funds provided for this study. We
   also want to thank the children, their parents, the school staff, and
   volunteers of the Western Cape Education department for their support
   and involvement during sample collection.
CR Acosta Maria T, 2003, Curr Neurol Neurosci Rep, V3, P149, DOI 10.1007/s11910-003-0067-0
   Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
   Alarcon M, 2002, AM J HUM GENET, V70, P60, DOI 10.1086/338241
   Alcantara S, 1998, J NEUROSCI, V18, P7779
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   BAUMAN ML, 1991, PEDIATRICS, V87, P791
   Bonora E, 2003, MOL PSYCHIATR, V8, P885, DOI 10.1038/sj.mp.4001310
   Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
   CAVINESS VS, 1973, J COMP NEUROL, V148, P141, DOI 10.1002/cne.901480202
   Costa E, 2001, NEUROBIOL DIS, V8, P723, DOI 10.1006/nbdi.2001.0436
   Courchesne E, 1997, CURR OPIN NEUROBIOL, V7, P269, DOI 10.1016/S0959-4388(97)80016-5
   Curtin C, 2010, BMC PEDIATR, V10, P1
   D'Arcangelo G, 1998, BIOESSAYS, V20, P235, DOI 10.1002/(SICI)1521-1878(199803)20:3<235::AID-BIES7>3.3.CO;2-4
   D'Arcangelo G, 1999, NEURON, V24, P471, DOI 10.1016/S0896-6273(00)80860-0
   Devlin B, 2004, AM J MED GENET B, V126B, P46, DOI 10.1002/ajmg.b.20125
   Dutta S, 2008, NEUROSCI LETT, V441, P56, DOI 10.1016/j.neulet.2008.06.022
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   FALCONER DS, 1951, J GENET, V50, P192, DOI 10.1007/BF02996215
   Fatemi S, 2004, MOL PSYCHIATR, V10, P251
   Fatemi SH, 2001, J AUTISM DEV DISORD, V31, P529, DOI 10.1023/A:1013234708757
   Fatemi SH, 2000, MOL PSYCHIATR, V5, P654, DOI 10.1038/sj.mp.4000783
   Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P25, DOI 10.1023/A:1015337611258
   Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559
   Gillberg C, 1999, DEV PSYCHOPATHOL, V11, P567, DOI 10.1017/S0954579499002217
   GOFFINET AM, 1979, ANAT EMBRYOL, V157, P205, DOI 10.1007/BF00305160
   Goffinet A M, 1984, Brain Res, V319, P261
   GOFFINET AM, 1992, INT J DEV BIOL, V36, P101
   Guidotti A, 2000, ARCH GEN PSYCHIAT, V57, P1061, DOI 10.1001/archpsyc.57.11.1061
   He YQ, 2011, PSYCHIAT RES, V187, P462, DOI 10.1016/j.psychres.2010.04.051
   Hong SE, 2000, NAT GENET, V26, P93
   Impagnatiello F, 1998, P NATL ACAD SCI USA, V95, P15718, DOI 10.1073/pnas.95.26.15718
   Kanner L, 1943, NERV CHILD, V2, P217
   Kemper TL, 1998, J NEUROPATH EXP NEUR, V57, P645, DOI 10.1097/00005072-199807000-00001
   Kim S, 2009, NEUROPSYCHOPHARMACOL, V35, P473
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Klauck SM, 2006, EUR J HUM GENET, V14, P714, DOI 10.1038/sj.ejhg.5201610
   Kogan M. D., 2007, PEDIATRICS, V124, P1395, DOI DOI 10.1542/PEDS.2009-1522
   Krebs MO, 2002, MOL PSYCHIATR, V7, P801, DOI 10.1038/sj.mp.4001071
   Kumar RA, 2009, CURR NEUROL NEUROSCI, V9, P188, DOI 10.1007/s11910-009-0029-2
   Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
   Li H, 2008, AM J MED GENET B, V147B, P194, DOI 10.1002/ajmg.b.30584
   Li J, 2004, AM J MED GENET B, V126B, P51, DOI 10.1002/ajmg.b.20122
   Li XH, 2012, BRAIN RES BULL, V88, P543, DOI 10.1016/j.brainresbull.2012.05.017
   Lugli Giovanni, 2003, BMC Biochem, V4, P9, DOI 10.1186/1471-2091-4-9
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850
   Pesold C, 1998, P NATL ACAD SCI USA, V95, P3221, DOI 10.1073/pnas.95.6.3221
   PICKLES A, 1995, AM J HUM GENET, V57, P717
   Pritchard JK, 2001, AM J HUM GENET, V69, P124, DOI 10.1086/321272
   Rice DS, 2001, ANNU REV NEUROSCI, V24, P1005, DOI 10.1146/annurev.neuro.24.1.1005
   Risch N, 1999, AM J HUM GENET, V65, P493, DOI 10.1086/302497
   RITVO ER, 1986, AM J PSYCHIAT, V143, P862
   Rodier PM, 2000, SCI AM, V282, P56
   Schaid DJ, 2002, AM J HUM GENET, V70, P425, DOI 10.1086/338688
   Schopler E., 1986, CHILDHOOD AUTISM RAT
   Schopler E, 1988, DIAGNOSIS ASSESSMENT
   Serajee FJ, 2006, GENOMICS, V87, P75, DOI 10.1016/j.ygeno.2005.09.008
   Skaar DA, 2005, MOL PSYCHIATR, V10, P563, DOI 10.1038/sj.mp.4001614
   Tissir F, 2003, NAT REV NEUROSCI, V4, P496, DOI 10.1038/nrn1113
   Turner M, 2000, MOL MED TODAY, V6, P238, DOI 10.1016/S1357-4310(00)01712-3
   Weeber EJ, 2002, J BIOL CHEM, V277, P39944, DOI 10.1074/jbc.M205147200
   Williams EL, 2011, TRANSL NEUROSCI, V2, P106, DOI 10.2478/s13380-011-0016-3
   Zhang H, 2002, MOL PSYCHIATR, V7, P1012, DOI 10.1038/sj.mp.4001124
NR 66
TC 1
Z9 1
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1945-0265
J9 GENET TEST MOL BIOMA
JI Genet. Test. Mol. Biomark.
PD FEB
PY 2013
VL 17
IS 2
BP 93
EP 98
DI 10.1089/gtmb.2012.0212
PG 6
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 074HK
UT WOS:000313803300003
PM 23216241
ER

PT J
AU Rios, JJ
   Paria, N
   Burns, DK
   Israel, BA
   Cornelia, R
   Wise, CA
   Ezaki, M
AF Rios, Jonathan J.
   Paria, Nandina
   Burns, Dennis K.
   Israel, Bonnie A.
   Cornelia, Reuel
   Wise, Carol A.
   Ezaki, Marybeth
TI Somatic gain-of-function mutations in PIK3CA in patients with
   macrodactyly
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; CANCER-SPECIFIC MUTATIONS;
   PROTEIN-KINASE-B; IN-VIVO; ACTIVATING MUTATIONS; DISEASE; GENE;
   P110-ALPHA/P85-ALPHA; SCHIZOPHRENIA
AB Macrodactyly is a discrete congenital anomaly consisting of enlargement of all tissues localized to the terminal portions of a limb, typically within a onerve territory'. The classic terminology for this condition is olipofibromatous hamartoma of nerve' or Type I macrodactyly. The peripheral nerve, itself, is enlarged both in circumference and in length. It is not related to neurofibromatosis (NF1), nor is it associated with vascular malformations, such as in the recently reported CLOVES syndrome. The specific nerve pathophysiology in this form of macrodactyly has not been well described and a genetic etiology for this specific form of enlargement is unknown. To identify the genetic cause of macrodactyly, we used whole-exome sequencing to identify somatic mutations present in the affected nerve of a single patient. We confirmed a novel mutation in PIK3CA (R115P) present in the patients affected nerve tissue but not in blood DNA. Sequencing PIK3CA exons identified gain-of-function mutations (E542K, H1047L or H1047R) in the affected tissue of five additional unrelated patients; mutations were absent in blood DNA available from three patients. Immunocytochemistry confirmed AKT activation in cultured cells from the nerve of a macrodactyly patient. Additionally, we found that the most abnormal structure within the involved nerve in a macrodactylous digit is the perineurium, with additional secondary effects on the axon number and size. Thus, isolated congenital macrodactyly is caused by somatic activation of the PI3K/AKT cell-signaling pathway and is genetically and biochemically related to other overgrowth syndromes.
C1 [Rios, Jonathan J.; Paria, Nandina; Israel, Bonnie A.; Cornelia, Reuel; Wise, Carol A.] Texas Scottish Rite Hosp Children, Sarah M & Charles E Seay Ctr Musculoskeletal Res, Dallas, TX 75219 USA.
   [Ezaki, Marybeth] Texas Scottish Rite Hosp Children, Charles E Seay Jr Hand Ctr, Dallas, TX 75219 USA.
   [Rios, Jonathan J.] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA.
   [Rios, Jonathan J.; Wise, Carol A.] Univ Texas SW Med Ctr Dallas, Eugene McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA.
   [Burns, Dennis K.] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA.
   [Wise, Carol A.; Ezaki, Marybeth] Univ Texas SW Med Ctr Dallas, Dept Orthopaed Surg, Dallas, TX 75390 USA.
RP Rios, JJ (reprint author), Texas Scottish Rite Hosp Children, Sarah M & Charles E Seay Ctr Musculoskeletal Res, 2222 Welborn St, Dallas, TX 75219 USA.
EM jonathan.rios@tsrh.org
FU Texas Scottish Rite Hospital for Children
FX This study was supported by Texas Scottish Rite Hospital for Children.
   Funding to pay the Open Access publication charges for this article was
   provided by Texas Scottish Rite Hospital for Children.
CR Alessi DR, 1996, EMBO J, V15, P6541
   Bader AG, 2005, NAT REV CANCER, V5, P921, DOI 10.1038/nrc1753
   Bader AG, 2006, P NATL ACAD SCI USA, V103, P1475, DOI 10.1073/pnas.0510857103
   Bamford S, 2004, BRIT J CANCER, V91, P355, DOI 10.1038/sj.bjc.6601894
   Bamshad MJ, 2011, NAT REV GENET, V12, P745, DOI 10.1038/nrg3031
   Calleja V, 2007, PLOS BIOL, V5, P780, DOI 10.1371/journal.pbio.0050095
   Cooper GM, 2005, GENOME RES, V15, P901, DOI 10.1101/gr.3577405
   Flatt A, 1994, CARE CONGENITAL HAND
   Girard SL, 2011, NAT GENET, V43, P860, DOI 10.1038/ng.886
   Gymnopoulos M, 2007, P NATL ACAD SCI USA, V104, P5569, DOI 10.1073/pnas.0701005104
   Hers I, 2011, CELL SIGNAL, V23, P1515, DOI 10.1016/j.cellsig.2011.05.004
   Ho CA, 2007, J BONE JOINT SURG AM, V89A, P1097, DOI 10.2106/JBJS.F.01378
   Holmes D, 2011, NAT REV DRUG DISCOV, V10, P563, DOI 10.1038/nrd3527
   Huang CH, 2008, CELL CYCLE, V7, P1151, DOI 10.4161/cc.7.9.5817
   Huang CH, 2007, SCIENCE, V318, P1744, DOI 10.1126/science.1150799
   Iacobas I, 2011, PEDIATR BLOOD CANCER, V57, P321, DOI 10.1002/pbc.23098
   Ikenoue T, 2005, CANCER RES, V65, P4562, DOI 10.1158/0008-5472.CAN-04-4114
   Kurek KC, 2012, AM J HUM GENET, V90, P1108, DOI 10.1016/j.ajhg.2012.05.006
   Lee JH, 2012, NAT GENET, V44, P941, DOI 10.1038/ng.2329
   Li H, 2009, BIOINFORMATICS, V25, P2078, DOI 10.1093/bioinformatics/btp352
   Li H, 2009, BIOINFORMATICS, V25, P1754, DOI 10.1093/bioinformatics/btp324
   Lindhurst MJ, 2011, NEW ENGL J MED, V365, P611, DOI 10.1056/NEJMoa1104017
   Lindhurst MJ, 2012, NAT GENET, V44, P928, DOI 10.1038/ng.2332
   Marsh DJ, 2008, NAT CLIN PRACT ONCOL, V5, P357, DOI 10.1038/ncponc1112
   McKenna A, 2010, GENOME RES, V20, P1297, DOI 10.1101/gr.107524.110
   Miled N, 2007, SCIENCE, V317, P239, DOI 10.1126/science.1135394
   Muzaffar AR, 2004, J HAND SURG-AM, V29A, P201, DOI 10.1016/j.jhsa.2003.10.017
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Ng SB, 2010, NAT GENET, V42, P30, DOI 10.1038/ng.499
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Rempel DM, 2004, J ELECTROMYOGR KINES, V14, P71, DOI 10.1016/j.jelekin.2003.09.009
   Riviere JB, 2012, NAT GENET, V44, P934, DOI 10.1038/ng.2331
   Samuels Y, 2004, SCIENCE, V304, P554, DOI 10.1126/science.1096502
   Segerstrom L, 2011, INT J CANCER, V129, P2958, DOI 10.1002/ijc.26268
   Siepel A, 2005, GENOME RES, V15, P1034, DOI 10.1101/gr.3715005
   Stransky N, 2011, SCIENCE, V333, P1157, DOI 10.1126/science.1208130
   Vanhaesebroeck B, 2001, ANNU REV BIOCHEM, V70, P535, DOI 10.1146/annurev.biochem.70.1.535
   Veltman JA, 2012, NAT REV GENET, V13, P565, DOI 10.1038/nrg3241
   Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
   Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
   Zhao L, 2008, P NATL ACAD SCI USA, V105, P2652, DOI 10.1073/pnas.0712169105
   Zhao L, 2008, ONCOGENE, V27, P5486, DOI 10.1038/onc.2008.244
NR 42
TC 21
Z9 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD FEB 1
PY 2013
VL 22
IS 3
BP 444
EP 451
DI 10.1093/hmg/dds440
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 070SO
UT WOS:000313531500003
PM 23100325
ER

PT J
AU Yazawa, M
   Dolmetsch, RE
AF Yazawa, Masayuki
   Dolmetsch, Ricardo E.
TI Modeling Timothy Syndrome with iPS Cells
SO JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
LA English
DT Article
DE Timothy syndrome; Calcium channelopathy; QT prolongation; Calcium
   signaling; Drug testing
ID PLURIPOTENT STEM-CELLS; LONG-QT SYNDROME; DEPENDENT-INACTIVATION;
   SYNDROME MUTATION; CHANNELS; RESTORATION; ARRHYTHMIA; INDUCTION;
   DEVELOP; MOUSE
AB Genetic mutations in ion channel genes that are associated with cardiac arrhythmias have been identified over the past several decades. However, little is known about the pathophysiological processes. An important limitation has been the difficulty of using human cardiomyocytes to study arrhythmias and identify drugs. To circumvent this issue, we have developed a method using human-induced pluripotent stem cells to generate cardiomyocytes from individuals with Timothy syndrome (TS), a genetic disorder characterized by QT prolongation, ventricular tachycardia, and autism. The TS ventricular-like cardiomyocytes exhibit deficits in contraction, electrical signaling, and calcium handling, as revealed by live cell imaging and electrophysiological studies. We tested candidate drugs in TS cardiomyocytes and found that roscovitine could successfully rescue these cellular phenotypes. The use of a human cellular model of cardiac arrhythmias provides a useful new platform not only to study disease mechanisms but also to develop new therapies to treat cardiac arrhythmias.
C1 [Yazawa, Masayuki; Dolmetsch, Ricardo E.] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA.
RP Dolmetsch, RE (reprint author), Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA.
EM ricardo.dolmetsch@stanford.edu
CR Bader PL, 2011, P NATL ACAD SCI USA, V108, P15432, DOI 10.1073/pnas.1112667108
   Barrett CF, 2008, P NATL ACAD SCI USA, V105, P2157, DOI 10.1073/pnas.0710501105
   Buganim Y, 2012, CELL, V150, P1209, DOI 10.1016/j.cell.2012.08.023
   Cheng EP, 2011, CIRC RES, V109, P255, DOI 10.1161/CIRCRESAHA.111.248252
   Cohen-Kutner M, 2012, SCI REP-UK, V2, DOI 10.1038/srep00366
   Flucher BE, 1996, P NATL ACAD SCI USA, V93, P8101, DOI 10.1073/pnas.93.15.8101
   Gillis J, 2012, AM J MED GENET A, V158A, P182, DOI 10.1002/ajmg.a.34355
   Grandi E, 2010, J MOL CELL CARDIOL, V48, P112, DOI 10.1016/j.yjmcc.2009.09.019
   He JQ, 2003, CIRC RES, V93, P32, DOI 10.1161/01.RES.0000080317.92718.99
   Itzhaki I, 2011, NATURE, V471, P225, DOI 10.1038/nature09747
   Jung CB, 2012, EMBO MOL MED, V4, P180, DOI 10.1002/emmm.201100194
   Laflamme MA, 2011, NATURE, V473, P326, DOI 10.1038/nature10147
   Moretti A, 2010, NEW ENGL J MED, V363, P1397, DOI 10.1056/NEJMoa0908679
   Okita K, 2011, NAT METHODS, V8, P409, DOI [10.1038/nmeth.1591, 10.1038/NMETH.1591]
   Otsuji TG, 2010, STEM CELL RES, V4, P201, DOI 10.1016/j.scr.2010.01.002
   Pasca SP, 2011, NAT MED, V17, P1657, DOI 10.1038/nm.2576
   Reichenbach H, 1992, Kinderarztl Prax, V60, P54
   Roden DM, 2005, J CLIN INVEST, V115, P2025, DOI 10.1172/JCI25539
   Seisenberger C, 2000, J BIOL CHEM, V275, P39193, DOI 10.1074/jbc.M006467200
   Splawski I, 2005, P NATL ACAD SCI USA, V102, P8089, DOI 10.1073/pnas.0502506102
   Splawski I., 2005, P NATL ACAD SCI USA, V102, P8086, DOI [10.1073/pnas.0502506102, DOI 10.1073/PNAS.050250]
   Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
   Sun N, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003552
   Takahashi K, 2007, NAT PROTOC, V2, P3081, DOI 10.1038/nprot.2007.418
   Takahashi K, 2007, CELL, V131, P861, DOI 10.1016/j.cell.2007.11.019
   Thiel WH, 2008, CIRCULATION, V118, P2225, DOI 10.1161/CIRCULATIONAHA.108.788067
   Venetucci L, 2012, NAT REV CARDIOL, V9, P561, DOI 10.1038/nrcardio.2012.93
   Warren L, 2010, CELL STEM CELL, V7, P618, DOI 10.1016/j.stem.2010.08.012
   Yang L, 2008, NATURE, V453, P524, DOI 10.1038/nature06894
   Yarotskyy V, 2010, J BIOL CHEM, V285, P43, DOI 10.1074/jbc.M109.076448
   Yarotskyy V, 2009, J PHYSIOL-LONDON, V587, P551, DOI 10.1113/jphysiol.2008.161737
   Yazawa M, 2011, NATURE, V471, P230, DOI 10.1038/nature09855
NR 32
TC 10
Z9 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1937-5387
J9 J CARDIOVASC TRANSL
JI J. Cardiovasc. Transl. Res.
PD FEB
PY 2013
VL 6
IS 1
SI SI
BP 1
EP 9
DI 10.1007/s12265-012-9444-x
PG 9
WC Cardiac & Cardiovascular Systems; Medicine, Research & Experimental
SC Cardiovascular System & Cardiology; Research & Experimental Medicine
GA 072GM
UT WOS:000313657700001
PM 23299782
ER

PT J
AU Leavey, A
   Zwaigenbaum, L
   Heavner, K
   Burstyn, I
AF Leavey, Anna
   Zwaigenbaum, Lonnie
   Heavner, Karyn
   Burstyn, Igor
TI Gestational Age at Birth and Risk of Autism Spectrum Disorders in
   Alberta, Canada
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID PRETERM BIRTH; NEONATAL FACTORS; OBSTETRIC COMPLICATIONS; EXTREME
   PREMATURITY; PERINATAL FACTORS; INFANTILE-AUTISM; CHILDREN; POPULATION;
   PREVALENCE; WEIGHT
AB Objective To examine the association between autism spectrum disorders (ASD) and each completed week of gestation using a graphical method of presenting results at all possible categorizations of gestational age (GA).
   Study design The risk of ASD in a total of 218 110 singleton live births with complete data from Alberta, Canada between 1998 and 2004 was examined through linkage to health insurance records. The relative risk of developing ASD according to the 21 dichotomizations of shorter gestation (GA <= 23 weeks vs >23 weeks to <= 43 weeks vs >43 weeks, in 1-week increments) was calculated using log-binomial regression and adjusted for fetal sex, socioeconomic status, and birth year.
   Results We observed a gradual increased risk of ASD with shorter gestation. Cutoffs only between 29 and 40 weeks clearly denoted an elevated risk of developing ASD compared with longer gestation, and the risk increased with earlier GA cutoff. The results were not affected by sex or measures of fetal growth.
   Conclusion Our data confirm the role of shortened gestation in ASD risk. We warn against the use of prespecified or a data-driven GA cutoff, however; instead, we recommend systematically examining all plausible cutoffs for GA to avoid overstating the homogeneity of risk in children on either side of a given cutoff, as well as to increase the comparability of studies. (J Pediatr 2013;162:361-8).
C1 [Leavey, Anna] Washington Univ, Dept Energy Environm & Chem Engn, Aerosol & Air Qual Res Lab, St Louis, MO USA.
   [Leavey, Anna; Heavner, Karyn; Burstyn, Igor] Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Philadelphia, PA 19102 USA.
   [Zwaigenbaum, Lonnie] Univ Alberta, Dept Pediat, Fac Med & Dent, Edmonton, AB, Canada.
RP Burstyn, I (reprint author), Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, 1505 Race St,Room 1332, Philadelphia, PA 19102 USA.
EM Igor.Burstyn@drexel.edu
FU Alberta Heritage Foundation for Medical Research
FX I.B. and L.Z. are supported by a Population Health Investigator award
   and a Health Scholar award, respectively, from the Alberta Heritage
   Foundation for Medical Research. This study is based on data supplied by
   Alberta Health and Wellness (AHW) and the Alberta Perinatal Health
   Program (APHP). The interpretation and conclusions contained herein are
   those of the researchers and do not necessarily represent the views of
   the Government of Alberta, AHW, or the APHP. The authors declare no
   conflicts of interest.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Aibar L, 2012, J PERINAT MED, V40, P271, DOI 10.1515/jpm-2011-0137
   American Psychological Association, 2001, DSM 4 TR DIAGN STAT
   Beck S, 2010, B WORLD HEALTH ORGAN, V88, P1
   Behrman RE, 2007, PRETERM BIRTH CAUSES
   Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927
   Brimacombe M, 2007, MATERN CHILD HLTH J, V11, P73, DOI 10.1007/s10995-006-0142-7
   BRYSON SE, 1988, J AM ACAD CHILD PSY, V27, P418, DOI 10.1097/00004583-198807000-00006
   Burstyn I, 2010, CHRONIC DIS CAN, V30, P125
   Callaghan WM, 2006, PEDIATRICS, V118, P1566, DOI 10.1542/peds.2006-0860
   Canadian Institute for Health Information, 2008, RED GAPS HLTH FOC SO
   Comi AM, 1999, J CHILD NEUROL, V14, P388, DOI 10.1177/088307389901400608
   Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334
   Dodds L, 2009, CHRONIC DIS CAN, V29, P102
   Eaton WW, 2001, J AUTISM DEV DISORD, V31, P279, DOI 10.1023/A:1010743203048
   Fombonne E, 2006, PEDIATRICS, V118, pE139, DOI 10.1542/peds.2005-2993
   GILLBERG C, 1983, J AUTISM DEV DISORD, V13, P153, DOI 10.1007/BF01531816
   Goldenberg RL, 2008, LANCET, V371, P75, DOI 10.1016/S0140-6736(08)60074-4
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Heavner KK, 2010, BMC MED RES METHODOL, V10, DOI 10.1186/1471-2288-10-59
   Hughes JR, 2008, EPILEPSY BEHAV, V13, P425, DOI 10.1016/j.yebeh.2008.06.015
   Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
   Johnson S, 2010, J PEDIATR-US, V156, P525, DOI 10.1016/j.jpeds.2009.10.041
   Johnson S, 2010, J AM ACAD CHILD PSY, V49, P453, DOI 10.1016/j.jaac.2010.02.002
   Joseph KS, 1998, NEW ENGL J MED, V339, P1434, DOI 10.1056/NEJM199811123392004
   Juul-Dam N, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.4.e63
   Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004
   Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
   Kramer MS, 2001, PEDIATRICS, V108, DOI 10.1542/peds.108.2.e35
   Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Limperopoulos C, 2009, CLIN PERINATOL, V36, P791, DOI 10.1016/j.clp.2009.07.010
   Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
   Mathews TJ, 2009, NATL VITAL STAT REPO
   Moster D, 2008, NEW ENGL J MED, V359, P262, DOI 10.1056/NEJMoa0706475
   Msall ME, 2010, J PEDIATR-US, V156, P519, DOI 10.1016/j.jpeds.2009.12.035
   Naggara O, 2011, AM J NEURORADIOL, V32, P437, DOI 10.3174/ajnr.A2425
   NELSON KB, 1991, PEDIATRICS, V87, P761
   Newcombe RG, 1998, STAT MED, V17, P857, DOI 10.1002/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E
   Newschaffer C. J., 2007, ANNU REV PUBL HEALTH, V28, P211
   O'Shea TM, 2009, EARLY HUM DEV, V85, P719, DOI 10.1016/j.earlhumdev.2009.08.060
   Phillips Carl V, 2004, BMC Med Res Methodol, V4, P20, DOI 10.1186/1471-2288-4-20
   Public Health Agency of Canada, 1999, MEAS HLTH SURV UPD C
   Reproductive Health Report Working Group, 2004, ALB REPR HLTH PREGN
   Schendel D, 2008, PEDIATRICS, V121, P1155, DOI 10.1542/peds.2007-1049
   Schieve LA, 2010, DISABIL HEALTH J, V3, P202, DOI 10.1016/j.dhjo.2009.12.001
   Sugie Y, 2005, AUTISM, V9, P487, DOI 10.1177/1362361305057877
   TUCHMAN RF, 1991, PEDIATRICS, V88, P1211
   Wier ML, 2006, DEV MED CHILD NEUROL, V48, P500, DOI 10.1017/S001216220600106X
NR 49
TC 5
Z9 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
J9 J PEDIATR-US
JI J. Pediatr.
PD FEB
PY 2013
VL 162
IS 2
BP 361
EP 368
DI 10.1016/j.jpeds.2012.07.040
PG 8
WC Pediatrics
SC Pediatrics
GA 071GX
UT WOS:000313579900029
PM 22947654
ER

PT J
AU Martin, MAC
   Manzanares, MCS
   Sanchez, JMR
AF Carbonero Martin, Miguel Angel
   Saiz Manzanares, Maria Consuelo
   Roman Sanchez, Jose Maria
TI Effect of a metacognitive training program of mentalist skills
SO PSICOTHEMA
LA English
DT Article
DE metacognitive training; mentalist skills; causal reasoning; predictive
   reasoning; belief attribution
ID APPEARANCE-REALITY DISTINCTION; FALSE-BELIEF; INDIVIDUAL-DIFFERENCES;
   MIND; CHILDRENS; LANGUAGE; EXPLANATION; ABILITY; DESIRES; AUTISM
AB Background: Recent researches in Theory of Mind (TOM) relate its development to the development of the metacognitive skills "planning," "regulation," and acquisition of "predictive and causal reasoning." These studies reveal the importance of metacognitive training in the development of mentalist skills. Method: In the present work, the effects of training were compared in 20 children, aged between 4 and 5 years. Results: Significant within-group differences in the skills of belief attribution and memory attribution were found and a tendency towards significance in the skills of behavior prediction. Significant between-group differences were found in belief attribution, prediction, and memory. Conclusions: Mentalist skills training improve attribution, prediction and memory skills in ToM tasks.
C1 [Carbonero Martin, Miguel Angel; Roman Sanchez, Jose Maria] Univ Valladolid, E-47002 Valladolid, Spain.
   [Saiz Manzanares, Maria Consuelo] Univ Burgos, Fac Humanidades & Educ, Burgos 09001, Spain.
RP Manzanares, MCS (reprint author), Univ Burgos, Fac Humanidades & Educ, Burgos 09001, Spain.
EM mcsmanzanares@ubu.es
CR Amsterlaw J, 2006, J COGN DEV, V7, P139, DOI 10.1207/s15327647jcd0702_1
   Atance CM, 2006, PSYCHOL SCI, V17, P583, DOI 10.1111/j.1467-9280.2006.01748.x
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Bartsch K, 1996, LEARN INDIVID DIFFER, V8, P281, DOI 10.1016/S1041-6080(96)90020-5
   BARTSCH K, 1989, CHILD DEV, V60, P946, DOI 10.1111/j.1467-8624.1989.tb03526.x
   Campbell D., 1966, EXPT DESIGN RES
   Carlson SM, 2004, J EXP CHILD PSYCHOL, V87, P299, DOI 10.1016/j.jecp.2004.01.002
   de la Fuente Arias Jesús, 2010, Psicothema, V22, P278
   Efklides A, 2009, PSICOTHEMA, V21, P76
   Fernandez-Duque D, 2000, CONSCIOUS COGN, V9, P288, DOI 10.1006/ccog.2000.0447
   Fivushs R., 1991, J NARRAT LIFE HIST, V1, P325
   Flavell E., 1986, MONOGRAPHS SOC RES C, V51
   Flavell J. H., 1983, HDB CHILD PSYCHOL, V3, P77
   Flavell J. H., 1993, COGNITIVE DEV
   FLAVELL JH, 1983, COGNITIVE PSYCHOL, V15, P95, DOI 10.1016/0010-0285(83)90005-1
   Forguson L, 1988, DEV THEORIES MIND, P226
   Frampton KL, 2009, EARLY CHILD RES Q, V24, P248, DOI 10.1016/j.ecresq.2009.04.004
   GOPNIK A, 1988, CHILD DEV, V59, P26, DOI 10.2307/1130386
   Hadwin J, 1996, DEV PSYCHOPATHOL, V8, P345
   Hickling AK, 2001, DEV PSYCHOL, V37, P668, DOI 10.1037//0012-1649.37.5.668
   Hughes C, 1998, DEV PSYCHOL, V34, P1026, DOI 10.1037/0012-1649.34.5.1026
   Kuhn D., 2000, CHILDRENS REASONING, P301
   Kuhn D., 1999, CHILD PSYCHOL HDB CO, P259
   Legare CH, 2009, COGNITIVE PSYCHOL, V58, P177, DOI 10.1016/j.cogpsych.2008.06.002
   Leslie AM, 1988, DEV THEORIES MIND, P19
   Milligan K, 2007, CHILD DEV, V78, P622, DOI 10.1111/j.1467-8624.2007.01018.x
   Moses L. J., 1999, MIT ENCY COGNITIVE S, P533
   Muris P, 1999, J AUTISM DEV DISORD, V29, P67, DOI 10.1023/A:1025922717020
   Nelson T. O., 1994, METACOGNITION KNOWIN, P1
   Nelson T. O., 1990, PSYCHOL LEARN MOTIV, V26, P125, DOI [10.1016/S0079-7421(08) 60053-5, DOI 10.1016/S0079-7421(08)60053-5]
   Perner J., 1987, PAKISTAN J PSYCHOL R, V2, P12
   PERNER J, 1995, J EXP CHILD PSYCHOL, V59, P516, DOI 10.1006/jecp.1995.1024
   Peskin J, 2004, COGNITIVE DEV, V19, P253, DOI 10.1016/j.cogdev.2004.01.003
   Pramling N., 2009, EARLY CHILD DEV CARE, V179, P329, DOI 10.1080/03004430601088130
   Ruffman T, 2002, CHILD DEV, V73, P734, DOI 10.1111/1467-8624.00435
   Sáiz Manzanares María Consuelo, 2010, Psicothema, V22, P772
   Saiz M. C., 2010, PROGRAMA DESARROLLO
   Saiz M.C., 2000, PSICOLOGIA INSTRUCCI, P53
   Schneider W., 2002, APPL METACOGNITION, P224, DOI 10.1017/CBO9780511489976.011
   SODIAN B, 1987, CHILD DEV, V58, P424, DOI 10.1111/j.1467-8624.1987.tb01390.x
   Steereman P., 1996, CLIN CHILD PSYCHOL P, V37, P157
   Stein N., 1982, VERBAL PROCESSES CHI, P83
   Swettenham J, 1996, J CHILD PSYCHOL PSYC, V37, P157, DOI 10.1111/j.1469-7610.1996.tb01387.x
   Tomasello M., 2007, ORIGENES CULTURALES
   Wechsler D., 1994, WECHSLER PRESCHOOL P
   Wellman H. M., 1990, CHILDS THEORY MIND
   Wellman HM, 2004, COGNITIVE DEV, V19, P479, DOI 10.1016/j.cogdev.2004.09.003
   WELLMAN HM, 1988, COGNITION, V30, P239, DOI 10.1016/0010-0277(88)90021-2
   WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
NR 49
TC 0
Z9 0
PU COLEGIO OFICIAL DE PSICOLOGOS DE ASTURIAS
PI OVIEDO
PA ILDEFONSO S. DEL RIO, 4-1 B, 33001 OVIEDO, SPAIN
SN 0214-9915
J9 PSICOTHEMA
JI Psicothema
PD FEB
PY 2013
VL 25
IS 1
BP 31
EP 37
DI 10.7334/psicothema2011.192
PG 7
WC Psychology, Multidisciplinary
SC Psychology
GA 072JD
UT WOS:000313666300006
ER

PT J
AU Jones, RR
   Blades, M
   Coleman, M
   Pascalis, O
AF Jones, Rebecca R.
   Blades, Mark
   Coleman, Mike
   Pascalis, Olivier
TI Learning new faces in typical and atypical populations of children
SO SCANDINAVIAN JOURNAL OF PSYCHOLOGY
LA English
DT Article
DE Autistic spectrum disorder (ASD); Face; learning
ID AUTISM SPECTRUM DISORDER; AUTOBIOGRAPHICAL MEMORY; PERCEPTION;
   DISCRIMINATION; RECOGNITION; FAMILIAR; ADULTS
AB Jones, R. R., Blades, M., Coleman, M. & Pascalis O. (2013). Learning new faces in typical and atypical populations of children. Scandinavian Journal of Psychology 54, 1013. Recognizing an individual as familiar is an important aspect of our social cognition, which requires both learning a face and recalling it. It has been suggested that children with autistic spectrum disorder (ASD) have deficits and abnormalities in face processing. We investigated whether the process by which unfamiliar faces become familiar differs in typically developing (TD) children, children with ASD, and children with developmental delay. Children were familiarized with a set of moving novel faces presented over a three-day period. Recognition of the learned faces was assessed at five time points during the three-day period. Both immediate and delayed recall of faces was tested. All groups showed improvements in face recognition at immediate recall, which indicated that learning had occurred. The TD population showed slightly better performance than the two other groups, however no difference was specific to the ASD group. All groups showed similar levels of improvements with time. Our results are discussed in terms of learning in ASD.
C1 [Jones, Rebecca R.; Blades, Mark] Univ Sheffield, Dept Psychol, Sheffield S10 2TN, S Yorkshire, England.
   [Coleman, Mike] UCL, London, England.
   [Pascalis, Olivier] CNRS, BSHM, F-38000 Grenoble, France.
RP Pascalis, O (reprint author), CNRS, BSHM, F-38000 Grenoble, France.
EM olivier.pascalis@upmf-grenoble.fr
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Bonner L, 2003, VIS COGN, V10, P527, DOI 10.1080/13506280244000168
   Bosseler A, 2003, J AUTISM DEV DISORD, V33, P653, DOI 10.1023/B:JADD.0000006002.82367.4f
   Boucher J, 1998, J CHILD PSYCHOL PSYC, V39, P171, DOI 10.1017/S0021963097001820
   Bruck M, 2007, DEV PSYCHOPATHOL, V19, P73, DOI 10.1017/S0954579407070058
   Cowan N., 1997, DEV MEMORY CHILDHOOD
   Crane L, 2008, J AUTISM DEV DISORD, V38, P498, DOI 10.1007/s10803-007-0420-2
   Frith U., 2003, AUTISM EXPLAINING EN
   Gernsbacher M. A., 2008, LEARNING MEMORY COMP
   Plaisted K, 2003, PHILOS T ROY SOC B, V358, P375, DOI 10.1098/rstb.2002.1211
   Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P765, DOI 10.1017/S0021963098002601
   Rondan C, 2003, CHILD NEUROPSYCHOL, V9, P289, DOI 10.1076/chin.9.4.289.23516
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
   Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x
   Wilson CE, 2010, PERCEPTION, V39, P1645, DOI 10.1068/p6727
   Wilson RR, 2007, BRIT J DEV PSYCHOL, V25, P375, DOI 10.1348/026151006X159112
   Wilson RR, 2009, INFANT CHILD DEV, V18, P545, DOI 10.1002/icd.638
NR 18
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0036-5564
J9 SCAND J PSYCHOL
JI Scand. J. Psychol.
PD FEB
PY 2013
VL 54
IS 1
SI SI
BP 10
EP 13
DI 10.1111/sjop.12006
PG 4
WC Psychology, Multidisciplinary
SC Psychology
GA 073DV
UT WOS:000313724600003
PM 23320881
ER

PT J
AU Strid, K
   Heimann, M
   Tjus, T
AF Strid, Karin
   Heimann, Mikael
   Tjus, Tomas
TI Pretend play, deferred imitation and parent-child interaction in
   speaking and non-speaking children with autism
SO SCANDINAVIAN JOURNAL OF PSYCHOLOGY
LA English
DT Article
DE Autism; pretend play; deferred imitation; parent interaction; recall
   memory; language level
ID JOINT ATTENTION; DIAGNOSTIC INTERVIEW; 24-MONTH-OLD INFANTS; SPECTRUM
   DISORDER; SYMBOLIC PLAY; COMMUNICATION; LANGUAGE; PREDICTORS; IMMEDIATE;
   MEMORY
AB Strid, K., Heimann, M. & Tjus T. (2013). Pretend play, deferred imitation and parent-child interaction in speaking and non-speaking children with autism. Scandinavian Journal of Psychology 54, 2632. This study investigates spontaneous pretend play during a parent-child free play observation, and deferred imitation observed in an experimental setting in speaking and non-speaking children with autism in comparison to children with typical development. Both groups of children with autism showed a reduced level of deferred imitation compared to the typically developing group, but only the non-speaking children with autism spent significantly less time in pretend play compared to children with typical development. Deferred imitation was related to parents verbal interaction in both groups. An analysis of the parent-child interaction revealed that parents of children with autism used less synchronized comments compared to parents of typically developing children. Parents of the speaking group with autism used more synchronized than unsynchronized comments, while parents of the non-speaking group used the same amount of synchronized and unsynchronized comments. These findings are discussed in terms of how the developmental level affects behavior and interaction in autism.
C1 [Strid, Karin] Univ Gothenburg, Dept Psychol, SE-40530 Gothenburg, Sweden.
   [Heimann, Mikael] Linkoping Univ, S-58183 Linkoping, Sweden.
RP Strid, K (reprint author), Univ Gothenburg, Dept Psychol, Box 500, SE-40530 Gothenburg, Sweden.
EM karin.strid@psy.gu.se
CR American Psychological Association (APA), 1994, DIAGN STAT MAN
   Barr R, 1996, INFANT BEHAV DEV, V19, P159, DOI 10.1016/S0163-6383(96)90015-6
   Berglund E, 2000, SCAND J PSYCHOL, V41, P133, DOI 10.1111/1467-9450.00181
   Billstedt E., 2007, THESIS GOTHENBURG U
   Bloom L, 2001, MONOGRAPHS SOC RES C, V66, p[i, 1], DOI DOI 10.1111/1540-5834.00163
   Charman T, 1997, J AUTISM DEV DISORD, V27, P325, DOI 10.1023/A:1025806616149
   Dawson G, 1998, CHILD DEV, V69, P1276, DOI 10.2307/1132265
   Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
   EHEART BK, 1982, AM J MENT DEF, V87, P20
   Eriksson M., 1999, 1 LANGUAGE, V19, P55, DOI 10.1177/014272379901905503
   TOMASELLO M, 1986, CHILD DEV, V57, P1454, DOI 10.1111/j.1467-8624.1986.tb00470.x
   GILLBERG C, 1991, J AM ACAD CHILD PSY, V30, P375, DOI 10.1097/00004583-199105000-00004
   Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
   Griffiths R, 1970, ABILITIES YOUNG CHIL
   Harris P. L., 1989, CHILDREN EMOTION
   Hedenbro M, 2007, CHILD LANG TEACH THE, V23, P201, DOI 10.1177/0265659007076294
   Heimann M., FOCUS AUTIS IN PRESS
   Heimann M, 2006, INFANT CHILD DEV, V15, P233, DOI 10.1002/icd.462
   Jarrold C, 2003, AUTISM, V7, P379, DOI 10.1177/1362361303007004004
   Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
   KASARI C, 1988, J ABNORM CHILD PSYCH, V16, P45, DOI 10.1007/BF00910499
   Kaufman AS, 1983, KAUFMAN ASSESSMENT B
   KONSTANTAREAS MM, 1988, J AUTISM DEV DISORD, V18, P647, DOI 10.1007/BF02211882
   LESLIE AM, 1987, PSYCHOL REV, V94, P412, DOI 10.1037/0033-295X.94.4.412
   Libby S, 1998, J AUTISM DEV DISORD, V28, P487, DOI 10.1023/A:1026095910558
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   McCarthy D., 1972, MCCARTHY SCALES CHIL
   McEwen F, 2007, CHILD DEV, V78, P474, DOI 10.1111/j.1467-8624.2007.01010.x
   Meltzoff A. N., 2004, THEORIES INFANT DEV, P145
   MELTZOFF AN, 1988, CHILD DEV, V59, P217, DOI 10.2307/1130404
   MELTZOFF AN, 1985, CHILD DEV, V56, P62, DOI 10.1111/j.1467-8624.1985.tb00086.x
   Morgan B, 2003, DEV PSYCHOL, V39, P646, DOI 10.1037/0012-1649.39.4.646
   Munson J, 2008, J INT NEUROPSYCH SOC, V14, P956, DOI 10.1017/S1355617708081393
   Nielsen M, 2004, INFANT BEHAV DEV, V27, P342, DOI 10.1016/j.infbeh.2003.12.006
   Noll LM, 2003, INF MENTAL HLTH J, V24, P557, DOI 10.1002/imhj.10071
   Norberg L., 1991, GRIFFITHS UTVECKLING
   Raven JC, 1976, COLOURED PROGR MATRI
   Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
   Rogers SJ, 2008, J CHILD PSYCHOL PSYC, V49, P449, DOI 10.1111/j.1469-7610.2007.01866.x
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771
   Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
   SLADE A, 1987, CHILD DEV, V58, P367, DOI 10.1111/j.1467-8624.1987.tb01384.x
   Strid K, 2006, INFANT BEHAV DEV, V29, P545, DOI 10.1016/j.infbeh.2006.07.002
   Tjus T, 2001, AUTISM, V5, P175, DOI 10.1177/1362361301005002007
   Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7
   Watson LR, 1998, J AUTISM DEV DISORD, V28, P51, DOI 10.1023/A:1026063003289
   Waxman S. R., 2002, BLACKWELL HDB CHILDH, P102, DOI 10.1002/9780470996652.ch5
   Wechsler D, 1999, WECHSLER PRESCHOOL P
   Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
   Wing L, 1997, HDB AUTISM PERVASIVE, P148
NR 51
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0036-5564
J9 SCAND J PSYCHOL
JI Scand. J. Psychol.
PD FEB
PY 2013
VL 54
IS 1
SI SI
BP 26
EP 32
DI 10.1111/sjop.12003
PG 7
WC Psychology, Multidisciplinary
SC Psychology
GA 073DV
UT WOS:000313724600006
PM 23121545
ER

PT J
AU Mekinian, A
   Lachassinne, E
   Nicaise-Roland, P
   Carbillon, L
   Motta, M
   Vicaut, E
   Boinot, C
   Avcin, T
   Letoumelin, P
   De Carolis, S
   Rovere-Querini, P
   Lambert, M
   Derenne, S
   Pourrat, O
   Stirnemann, J
   Chollet-Martin, S
   Biasini-Rebaioli, C
   Rovelli, R
   Lojacono, A
   Ambrozic, A
   Botta, A
   Benbara, A
   Pierre, F
   Allegri, F
   Nuzzo, M
   Hatron, PY
   Tincani, A
   Fain, O
   Aurousseau, MH
   Boffa, MC
AF Mekinian, Arsene
   Lachassinne, Eric
   Nicaise-Roland, Pascale
   Carbillon, Lionel
   Motta, Mario
   Vicaut, Eric
   Boinot, Catherine
   Avcin, Tadej
   Letoumelin, Philippe
   De Carolis, Sara
   Rovere-Querini, Patrizia
   Lambert, Marc
   Derenne, Sophie
   Pourrat, Olivier
   Stirnemann, Jerome
   Chollet-Martin, Sylvie
   Biasini-Rebaioli, Chiara
   Rovelli, Rosanna
   Lojacono, Andrea
   Ambrozic, Ales
   Botta, Angela
   Benbara, Amelie
   Pierre, Fabrice
   Allegri, Flavio
   Nuzzo, Monica
   Hatron, Pierre-Yves
   Tincani, Angela
   Fain, Olivier
   Aurousseau, Marie-Helene
   Boffa, Marie-Claire
TI European registry of babies born to mothers with antiphospholipid
   syndrome
SO ANNALS OF THE RHEUMATIC DISEASES
LA English
DT Article
ID INTERNATIONAL CONSENSUS STATEMENT; CHILDREN BORN; NEUROPSYCHOLOGICAL
   DEVELOPMENT; CLASSIFICATION CRITERIA; AUTOIMMUNE-DISEASE;
   HEALTHY-CHILDREN; INFANTS BORN; I ANTIBODIES; ANTICARDIOLIPIN; PREGNANCY
AB Objectives This study aimed to describe the long-term outcome and immunological status of children born to mothers with antiphospholipid syndrome, to determine the factors responsible for childhood abnormalities, and to correlate the child's immunological profile with their mothers.
   Methods A prospective follow-up of a European multicentre cohort was conducted. The follow-up consisted of clinical examination, growth data, neurodevelopmental milestones and antiphospholipid antibodies (APL) screening. Children were examined at 3, 9, 24 months and 5 years.
   Results 134 children were analysed (female sex in 65 cases, birth weight 3000 +/- 500 g, height 48 +/- 3 cm). Sixteen per cent had a preterm birth (< 37 weeks; n=22), and 14% weighted less than 2500 g at birth (n=19). Neonatal complications were noted in 18 cases (13%), with five infections (4%). During the 5-year follow-up, no thrombosis or systemic lupus erythematosus (SLE) was noted. Four children displayed behavioural abnormalities, which consisted of autism, hyperactive behaviour, feeding disorder with language delay and axial hypotony with psychomotor delay. At birth lupus anticoagulant was present in four (4%), anticardiolipin antibodies (ACL) IgG in 18 (16%), anti-beta(2) glycoprotein-I (anti-beta 2GPI) IgG/M in 16 (15%) and three (3%), respectively. ACL IgG and anti-beta 2GPI disappeared at 6 months in nine (17%) and nine (18%), whereas APL persisted in 10% of children. ACL and anti-beta 2GPI IgG were correlated with the same mother's antibodies before 6 months of age (p < 0.05).
   Conclusion Despite the presence of APL in children, thrombosis or SLE were not observed. The presence of neurodevelopmental abnormalities seems to be more important in these children, and could justify long-term follow-up.
C1 [Mekinian, Arsene; Stirnemann, Jerome; Fain, Olivier] Univ Paris 13, Serv Med Interne, F-93140 Bondy, France.
   [Lachassinne, Eric] Univ Paris 13, Serv Neonatol & Pediat, F-93140 Bondy, France.
   [Nicaise-Roland, Pascale; Chollet-Martin, Sylvie] Hop Bichat Claude Bernard, AP HP, Unite Fonct Immunol Autoimmunite & Hypersensibili, F-75877 Paris 18, France.
   [Carbillon, Lionel; Benbara, Amelie] Univ Paris 13, Serv Gynecol Obstet, F-93140 Bondy, France.
   [Motta, Mario; Biasini-Rebaioli, Chiara; Lojacono, Andrea; Allegri, Flavio; Nuzzo, Monica; Tincani, Angela] Univ Brescia, Spedali Civili, Rheumatol Obstet Neonatol & Neonatal Intens Care, Brescia, Italy.
   [Vicaut, Eric] Univ Paris 07, Hop Lariboisiere, AP Hop Paris, Serv Epidemiol & Biostat, Paris, France.
   [Boinot, Catherine; Pourrat, Olivier; Pierre, Fabrice] CHU Poitiers, Serv Hematol Biol, Poitiers, France.
   [Avcin, Tadej; Ambrozic, Ales] Univ Chidrens Hosp Ljubljana, Univ Med Ctr, Ljubljana, Slovenia.
   [Letoumelin, Philippe] Univ Paris 13, Hop Avicenne, AP Hop Paris, Serv Epidemiol & Biostat, F-93140 Bondy, France.
   [De Carolis, Sara; Botta, Angela] Univ Cattolica Sacro Cuore, I-00168 Rome, Italy.
   [Rovere-Querini, Patrizia; Rovelli, Rosanna] San Rafaele Sci Inst, Milan, Italy.
   [Lambert, Marc; Hatron, Pierre-Yves] Univ Lille 2, Hop Claude Huriez, Serv Med Interne, Lille, France.
   [Derenne, Sophie] CHU Nantes, Serv Hematol Biol, F-44035 Nantes 01, France.
   [Aurousseau, Marie-Helene; Boffa, Marie-Claire] Univ Paris 13, Serv Hematol Biol, F-93140 Bondy, France.
RP Mekinian, A (reprint author), Univ Paris 13, Hop Jean Verdier, AP HP, Serv Med Interne, F-93140 Bondy, France.
EM arsene.mekinian@jvr.aphp.fr
RI Tincani, Angela/E-7608-2010
CR Andreoli L, 2011, ANN RHEUM DIS, V70, P380, DOI 10.1136/ard.2010.137281
   Avcin T, 2001, RHEUMATOLOGY, V40, P565, DOI 10.1093/rheumatology/40.5.565
   Boffa MC, 2007, LUPUS, V16, P634, DOI 10.1177/0961203307079039
   Boffa MC, 2004, LUPUS, V13, P713, DOI 10.1191/0961203304lu1089oa
   Brewster JA, 1999, J PERINAT MED, V27, P183, DOI 10.1515/JPM.1999.025
   Caronti B, 1998, J AUTOIMMUN, V11, P425, DOI 10.1006/jaut.1998.0214
   Keil A, 2010, EPIDEMIOLOGY, V21, P805, DOI 10.1097/EDE.0b013e3181f26e3f
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Miyakis S, 2006, J THROMB HAEMOST, V4, P295, DOI 10.1111/j.1538-7836.2006.01753.x
   Motta M, 2006, AM J PERINAT, V23, P247, DOI 10.1055/s-2006-939533
   Nacinovich R, 2008, ARTHRIT RHEUM-ARTHR, V59, P345, DOI 10.1002/art.23311
   Neri F, 2004, LUPUS, V13, P805, DOI 10.1191/0961203304lu2018oa
   Nicaise-Roland P, 2008, THROMB HAEMOSTASIS, V99, P1
   Pinto-Martin JA, 2011, PEDIATRICS, V128, P883, DOI 10.1542/peds.2010-2846
   Ross G, 2003, ARCH PEDIAT ADOL MED, V157, P397, DOI 10.1001/archpedi.157.4.397
   Ruffatti A, 2009, THROMB RES, V123, P482, DOI 10.1016/j.thromres.2008.03.012
   Shrot S, 2002, LUPUS, V11, P736, DOI 10.1191/0961203302lu255oa
   Wilson WA, 1999, ARTHRITIS RHEUM, V42, P1309, DOI 10.1002/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F
   ZURGIL N, 1993, LUPUS, V2, P233, DOI 10.1177/096120339300200405
NR 19
TC 19
Z9 19
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-4967
J9 ANN RHEUM DIS
JI Ann. Rheum. Dis.
PD FEB
PY 2013
VL 72
IS 2
BP 217
EP 222
DI 10.1136/annrheumdis-2011-201167
PG 6
WC Rheumatology
SC Rheumatology
GA 067BA
UT WOS:000313265800009
PM 22589374
ER

PT J
AU Novogrodsky, R
AF Novogrodsky, Rama
TI Subject pronoun use by children with autism spectrum disorders (ASD)
SO CLINICAL LINGUISTICS & PHONETICS
LA English
DT Article
DE autism; pronouns; narrative; production
ID LANGUAGE; ACQUISITION; DISCOURSE; DEFICITS; SYNTAX
AB In the current study, storytelling and story retelling by children with autism spectrum disorder (ASD) were analyzed to explore ambiguous third-person pronoun use in narratives. Twenty-three children diagnosed with ASD aged 6;1 to 14;3 and 17 typically-developing (TD) children aged 5;11 to 14;4 participated in the study. In the retelling task, no significant difference between the groups was found, suggesting that in less challenging tasks, children with ASD produce third-person subject pronouns appropriately. In the storytelling task, children with ASD produced more ambiguous third-person subject pronouns than did the TD children. The findings suggest a model in which children with ASD show deficits in the pragmatic domain of producing narratives.
C1 Boston Univ, Programs Deaf Studies, Ctr Study Commun & Deaf, Boston, MA 02215 USA.
RP Novogrodsky, R (reprint author), Boston Univ, Programs Deaf Studies, Ctr Study Commun & Deaf, 621 Commonwealth Ave, Boston, MA 02215 USA.
EM ramanovo@gmail.com
FU NIDCD [U19 DC 03610]
FX The author thanks Barbara Pearson, Einat Shetreet, Kathleen Corriveau
   and Lisa Edelson for their comments on an earlier version of the
   manuscript and the students who transcribed and coded the language
   samples. The author thanks Helen Tager-Flusberg for her support and for
   sharing this valuable data set. This study was supported by the grant
   number U19 DC 03610 from the NIDCD.
CR ARIEL Mira, 2001, TEXT REPRESENTATION, P29
   Arnold JE, 2009, COGNITION, V110, P131, DOI 10.1016/j.cognition.2008.10.016
   Baltaxe CA, 1977, J PEDIATR PSYCHOL, V2, P176, DOI DOI 10.1093/JPEPSY/2.4.176
   Bamberg M., 1994, RELATING EVENTS NARR, P189
   BARONCOHEN S, 1988, J AUTISM DEV DISORD, V18, P379, DOI 10.1007/BF02212194
   Berman R., 1994, RELATION EVENTS NARR, P608
   Berman RA, 2009, CAMB HB LANG LINGUIS, P355
   Bishop DVM, 2005, BRIT J DEV PSYCHOL, V23, P25, DOI 10.1348/026151004X20685
   BLOOM L, 1980, J CHILD LANG, V7, P235
   Botting N, 2002, CHILD LANG TEACH THE, V18, P1, DOI 10.1191/0265659002ct224oa
   Burack JA, 2004, J AUTISM DEV DISORD, V34, P65, DOI 10.1023/B:JADD.0000018076.90715.00
   Chierchia G., 1990, MEANING GRAMMAR INTR, P334
   Colle L, 2008, J AUTISM DEV DISORD, V38, P28, DOI 10.1007/s10803-007-0357-5
   Condouris K., 2003, AM J SPEECH-LANG PAT, V12, P3
   Hamann C, 2011, STUD THEOR PSYCHOLIN, V41, P247, DOI 10.1007/978-94-007-1688-9_7
   Hobson Peter R., 2010, J AUTISM DEV DISORD, V40, P653
   Jarrold C, 2004, J AUTISM DEV DISORD, V34, P81, DOI 10.1023/B:JADD.0000018078.82542.ab
   Kanner L, 1943, NERV CHILD, V2, P217
   Karmiloff-Smith A., 1985, LANG COGNITIVE PROC, V1, P61, DOI 10.1080/01690968508402071
   Kelley E, 2006, J AUTISM DEV DISORD, V36, P807, DOI 10.1007/s10803-006-0111-4
   LEE A, 1994, J AUTISM DEV DISORD, V24, P155, DOI 10.1007/BF02172094
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Mayer M., 1969, FROG ARE YOU
   Miller J., 2008, SYSTEMATIC ANAL LANG
   Renfrew C., 1991, BUS STORY TEST CONTI
   Richard M., 1999, J CHILD LANG, V26, P681
   Riches NG, 2010, INT J LANG COMM DIS, V45, P47, DOI 10.3109/13682820802647676
   TAGERFLUSBERG H, 1991, J CHILD PSYCHOL PSYC, V32, P1123, DOI 10.1111/j.1469-7610.1991.tb00353.x
   Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335
   Tager-Flusberg H, 2004, DEVELOPMENTAL LANGUAGE DISORDERS: FROM PHENOTYPES TO ETIOLOGIES, P31
   TAGERFLUSBERG H, 1990, J AUTISM DEV DISORD, V20, P1, DOI 10.1007/BF02206853
   TAGERFLUSBERG H, 1995, BRIT J DEV PSYCHOL, V13, P45
   TAGERFLUSBERG H, 1994, CONSTRAINTS LANGUAGE
   Wigglesworth G, 1997, J CHILD LANG, V24, P279, DOI 10.1017/S0305000997003048
   Woodcock R. W., 2001, WOODCOCK JOHNSON 3
NR 36
TC 3
Z9 3
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0269-9206
J9 CLIN LINGUIST PHONET
JI Clin. Linguist. Phon.
PD FEB
PY 2013
VL 27
IS 2
BP 85
EP 93
DI 10.3109/02699206.2012.742567
PG 9
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 067JC
UT WOS:000313289100001
PM 23294224
ER

PT J
AU Qiao, Y
   Tyson, C
   Hrynchak, M
   Lopez-Rangel, E
   Hildebrand, J
   Martell, S
   Fawcett, C
   Kasmara, L
   Calli, K
   Harvard, C
   Liu, X
   Holden, JJA
   Lewis, SME
   Rajcan-Separovic, E
AF Qiao, Y.
   Tyson, C.
   Hrynchak, M.
   Lopez-Rangel, E.
   Hildebrand, J.
   Martell, S.
   Fawcett, C.
   Kasmara, L.
   Calli, K.
   Harvard, C.
   Liu, X.
   Holden, J. J. A.
   Lewis, S. M. E.
   Rajcan-Separovic, E.
TI Clinical application of 2.7M Cytogenetics array for CNV detection in
   subjects with idiopathic autism and/or intellectual disability
SO CLINICAL GENETICS
LA English
DT Article
DE ASDs; CNVs; ID; QMPSF; whole-genome arrays
ID COPY NUMBER VARIATION; MENTAL-RETARDATION; CONGENITAL-ANOMALIES; SNP
   ARRAY; DMD GENE; INDIVIDUALS; DISORDERS; VARIANTS; SPECTRUM
AB Qiao Y, Tyson C, Hrynchak M, Lopez-Rangel E, Hildebrand J, Martell S, Fawcett C, Kasmara L, Calli K, Harvard C, Liu X, Holden JJA, Lewis SME, Rajcan-Separovic E. Clinical application of 2.7M Cytogenetics array for CNV detection in subjects with idiopathic autism and/or intellectual disability. Higher resolution whole-genome arrays facilitate the identification of smaller copy number variations (CNVs) and their integral genes contributing to autism and/or intellectual disability (ASD/ID). Our study describes the use of one of the highest resolution arrays, the Affymetrix (R) Cytogenetics 2.7M array, coupled with quantitative multiplex polymerase chain reaction (PCR) of short fluorescent fragments (QMPSF) for detection and validation of small CNVs. We studied 82 subjects with ASD and ID in total (30 in the validation and 52 in the application cohort) and detected putatively pathogenic CNVs in 6/52 cases from the application cohort. This included a 130-kb maternal duplication spanning exons 6479 of the DMD gene which was found in a 3-year-old boy manifesting autism and mild neuromotor delays. Other pathogenic CNVs involved 4p14, 12q24.31, 14q32.31, 15q13.2-13.3, and 17p13.3. We established the optimal experimental conditions which, when applied to select small CNVs for QMPSF confirmation, reduced the false positive rate from 60% to 25%. Our work suggests that selection of small CNVs based on the function of integral genes, followed by review of array experimental parameters resulting in highest confirmation rate using multiplex PCR, may enhance the usefulness of higher resolution platforms for ASD and ID gene discovery.
C1 [Qiao, Y.; Martell, S.; Kasmara, L.; Calli, K.; Harvard, C.; Lewis, S. M. E.; Rajcan-Separovic, E.] BC Child & Family Res Inst, Vancouver, BC, Canada.
   [Qiao, Y.; Martell, S.; Harvard, C.; Rajcan-Separovic, E.] Univ British Columbia, Dept Pathol Cytogenet, Vancouver, BC V5Z 4H4, Canada.
   [Qiao, Y.; Lopez-Rangel, E.; Hildebrand, J.; Kasmara, L.; Calli, K.; Lewis, S. M. E.] Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 4H4, Canada.
   [Qiao, Y.; Tyson, C.; Hrynchak, M.; Hildebrand, J.; Kasmara, L.; Calli, K.; Liu, X.; Holden, J. J. A.; Lewis, S. M. E.; Rajcan-Separovic, E.] Univ British Columbia, Autism Spectrum Interdisciplinary Res ASPIRE Prog, Vancouver, BC V5Z 4H4, Canada.
   [Tyson, C.; Hrynchak, M.; Fawcett, C.] Royal Columbian Hosp, Cytogenet Lab, New Westminster, BC, Canada.
   [Liu, X.; Holden, J. J. A.] Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, Canada.
   [Holden, J. J. A.] Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada.
RP Rajcan-Separovic, E (reprint author), Univ British Columbia, Dept Pathol, Child & Family Res Inst, 950 W 28th,Room 3060, Vancouver, BC V5Z 4H4, Canada.
EM eseparovic@cw.bc.ca; sume@mail.ubc.ca; eseparovic@cw.bc.ca
FU Canadian Institutes for Health Research (CIHR) [RT-64217, MOP 74502];
   Autism Speaks; CIHR Interdisciplinary Health Research Team grant
   [RT-43820]; Ontario Mental Health Foundation
FX This work was supported by funding from the Canadian Institutes for
   Health Research (CIHR) (RT-64217; PI: S. M. E. L. and MOP 74502; PI: E.
   R. S.), Autism Speaks (PI: S. M. E. L.), a CIHR Interdisciplinary Health
   Research Team grant (RT-43820) to ASD-CARC (PI: J. J. A. H.)
   (http://www.AutismResearch.com), and the Ontario Mental Health
   Foundation (PI: J. J. A. H.). S. M. E. L. and E. R-S. are Career
   Investigators with the Michael Smith Foundation for Health Research. The
   authors wish to thank Dr Tanya Nelson for useful discussions related to
   DMD gene.
CR Bernardini L, 2010, EUR J HUM GENET, V18, P178, DOI 10.1038/ejhg.2009.154
   Friedman JM, 2009, BMC GENOMICS, V10, DOI 10.1186/1471-2164-10-526
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Rajcan-Separovic E, 2010, HUM REPROD, V25, P2913, DOI 10.1093/humrep/deq202
   Rauch A, 2004, J MED GENET, V41, P916, DOI 10.1136/jmg.2004.022855
   Sagoo GS, 2009, GENET MED, V11, P139, DOI 10.1097/GIM.0b013e318194ee8f
   Sharp AJ, 2008, NAT GENET, V40, P322, DOI 10.1038/ng.93
   White SJ, 2006, CYTOGENET GENOME RES, V115, P240, DOI 10.1159/000095920
   White SJ, 2006, HUM MUTAT, V27, P938, DOI 10.1002/humu.20367
NR 12
TC 11
Z9 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-9163
J9 CLIN GENET
JI Clin. Genet.
PD FEB
PY 2013
VL 83
IS 2
BP 145
EP 154
DI 10.1111/j.1399-0004.2012.01860.x
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 065AZ
UT WOS:000313120400006
PM 22369279
ER

PT J
AU Dixit, A
   Mckee, S
   Mansour, S
   Mehta, SG
   Tanteles, GA
   Anastasiadou, V
   Patsalis, PC
   Martin, K
   McCullough, S
   Suri, M
   Sarkar, A
AF Dixit, A.
   McKee, S.
   Mansour, S.
   Mehta, S. G.
   Tanteles, G. A.
   Anastasiadou, V.
   Patsalis, P. C.
   Martin, K.
   McCullough, S.
   Suri, M.
   Sarkar, A.
TI 7q11.23 Microduplication: a recognizable phenotype
SO CLINICAL GENETICS
LA English
DT Article
DE autism spectrum disorder; 7q11; 23 microduplication; speech delay;
   Williams-Beuren critical region
ID EXPRESSIVE-LANGUAGE DELAY; WILLIAMS-BEUREN REGION; MENTAL-RETARDATION;
   INCLUDING DUPLICATIONS; DYSMORPHIC FEATURES; AUTISM; TRIPLICATION;
   SPECTRUM; PATIENT; SPEECH
AB Dixit A, McKee S, Mansour S, Mehta SG, Tanteles GA, Anastasiadou V, Patsalis PC, Martin K, McCullough S, Suri M, Sarkar A. 7q11.23 Microduplication: a recognizable phenotype. Williams-Beuren syndrome is a well-known microdeletion syndrome with a recognizable clinical phenotype. The subtle phenotype of the reciprocal microduplication of the Williams-Beuren critical region has been described recently. We report seven further patients, and a transmitting parent, with 7q11.23 microduplication. All our patients had speech delay, autistic features and facial dysmorphism consistent with the published literature. We conclude that the presence of specific dysmorphic features, including straight, neat eyebrows, thin lips and a short philtrum, in our patients with speech delay and autistic features provides further evidence that the children with 7q11.23 microduplication have a recognizable phenotype.
C1 [Dixit, A.; Suri, M.; Sarkar, A.] City Hosp Nottingham, Dept Clin Genet, Nottingham NG5 1PB, England.
   [McKee, S.] Belfast City Hosp, No Ireland Reg Genet Serv, Belfast BT9 7AD, Antrim, North Ireland.
   [Mansour, S.] Univ London, SW Thames Reg Genet Serv, London, England.
   [Mehta, S. G.] Addenbrookes Hosp, E Anglian Med Genet Serv, Cambridge, England.
   [Tanteles, G. A.; Anastasiadou, V.; Patsalis, P. C.] Cyprus Inst Neurol & Genet, Nicosia, Cyprus.
   [Martin, K.] City Hosp Nottingham, Dept Cytogenet, Nottingham NG5 1PB, England.
   [McCullough, S.] Belfast City Hosp, Dept Cytogenet, Belfast BT9 7AD, Antrim, North Ireland.
RP Sarkar, A (reprint author), City Hosp Nottingham, Dept Clin Genet, Hucknall Rd, Nottingham NG5 1PB, England.
EM ajoy.sarkar@nuh.nhs.uk
CR Berg JS, 2007, GENET MED, V9, P427, DOI 10.1097/GIM.0b013e3180986192
   Beunders G, 2010, J MED GENET, V47, P271, DOI 10.1136/jmg.2009.070490
   Depienne C, 2007, J MED GENET, V44, P452, DOI 10.1136/jmg.2006.047092
   Donnai D, 2000, AM J MED GENET, V97, P164, DOI 10.1002/1096-8628(200022)97:2<164::AID-AJMG8>3.0.CO;2-F
   Kent WJ, 2002, GENOME RES, V12, P996, DOI 10.1101/gr.229102
   Kirchhoff M, 2007, EUR J MED GENET, V50, P33, DOI 10.1016/j.ejmg.2006.10.002
   Kriek M, 2006, EUR J HUM GENET, V14, P180, DOI 10.1038/sj.ejhg.5201540
   Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
   Merritt JL, 2008, AM J MED GENET A, V146A, P1055, DOI [10.1002/ajmg.a.32235, 10.1002/ajmg.a32235]
   Orellana C, 2008, J MED GENET, V45, P187, DOI 10.1136/jmg.2007.054064
   Phatak V, 2011, J MED GENET, V48, pS59
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Somerville MJ, 2005, NEW ENGL J MED, V353, P1694, DOI 10.1056/NEJMoa051962
   Stromme P, 2002, J CHILD NEUROL, V17, P269, DOI 10.1177/088307380201700406
   Thomas NS, 2006, EUR J HUM GENET, V14, P831, DOI 10.1038/sj.ejhg.5201617
   Torniero C, 2008, EUR J HUM GENET, V16, P880, DOI 10.1038/ejhg.2008.42
   Torniero C, 2007, EUR J HUM GENET, V15, P62, DOI 10.1038/sj.ejhg.5201730
   Van der Aa N, 2009, EUR J MED GENET, V52, P94, DOI 10.1016/j.ejmg.2009.02.006
NR 18
TC 5
Z9 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-9163
J9 CLIN GENET
JI Clin. Genet.
PD FEB
PY 2013
VL 83
IS 2
BP 155
EP 161
DI 10.1111/j.1399-0004.2012.01862.x
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 065AZ
UT WOS:000313120400007
PM 22369319
ER

PT J
AU Hua, X
   Thompson, PM
   Leow, AD
   Madsen, SK
   Caplan, R
   Alger, JR
   O'Neill, J
   Joshi, K
   Smalley, SL
   Toga, AW
   Levitt, JG
AF Hua, Xue
   Thompson, Paul M.
   Leow, Alex D.
   Madsen, Sarah K.
   Caplan, Rochelle
   Alger, Jeffry R.
   O'Neill, Joseph
   Joshi, Kishori
   Smalley, Susan L.
   Toga, Arthur W.
   Levitt, Jennifer G.
TI Brain growth rate abnormalities visualized in adolescents with autism
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE autism spectrum disorder; longitudinal; MRI; tensor-based morphometry;
   development; white matter
ID TENSOR-BASED MORPHOMETRY; MILD COGNITIVE IMPAIRMENT; HIGH-FUNCTIONING
   AUTISM; IMAGE REGISTRATION; ALZHEIMERS-DISEASE; CORTICAL THICKNESS;
   SPECTRUM DISORDER; SPATIAL NORMALIZATION; DIAGNOSTIC INTERVIEW;
   CORPUS-CALLOSUM
AB Autism spectrum disorder is a heterogeneous disorder of brain development with wide ranging cognitive deficits. Typically diagnosed before age 3, autism spectrum disorder is behaviorally defined but patients are thought to have protracted alterations in brain maturation. With longitudinal magnetic resonance imaging (MRI), we mapped an anomalous developmental trajectory of the brains of autistic compared with those of typically developing children and adolescents. Using tensor-based morphometry, we created 3D maps visualizing regional tissue growth rates based on longitudinal brain MRI scans of 13 autistic and seven typically developing boys (mean age/interscan interval: autism 12.0 +/- 2.3 years/2.9 +/- 0.9 years; control 12.3 +/- 2.4/2.8 +/- 0.8). The typically developing boys demonstrated strong whole brain white matter growth during this period, but the autistic boys showed abnormally slowed white matter development (P = 0.03, corrected), especially in the parietal (P = 0.008), temporal (P = 0.03), and occipital lobes (P = 0.02). We also visualized abnormal overgrowth in autism in gray matter structures such as the putamen and anterior cingulate cortex. Our findings reveal aberrant growth rates in brain regions implicated in social impairment, communication deficits and repetitive behaviors in autism, suggesting that growth rate abnormalities persist into adolescence. Tensor-based morphometry revealed persisting growth rate anomalies long after diagnosis, which has implications for evaluation of therapeutic effects. Hum Brain Mapp, 2013. (C) 2011 Wiley Periodicals, Inc.
C1 [Hua, Xue; Thompson, Paul M.; Leow, Alex D.; Madsen, Sarah K.; Toga, Arthur W.] Univ Calif Los Angeles, Sch Med, Lab Neuro Imaging, Los Angeles, CA 90095 USA.
   [Alger, Jeffry R.] Univ Calif Los Angeles, Sch Med, Dept Neurol, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA.
   [Levitt, Jennifer G.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst 47 417C, Div Child Psychiat,Sch Med, Los Angeles, CA 90095 USA.
   [Leow, Alex D.] Univ Calif Los Angeles, Sch Med, Semel Inst Neurosci, Los Angeles, CA 90095 USA.
RP Levitt, JG (reprint author), Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst 47 417C, Div Child Psychiat,Sch Med, BOX 951759,760 Westwood Plaza, Los Angeles, CA 90095 USA.
EM jlevitt@mednet.ucla.edu
RI Leow, Alex/K-3236-2014
OI Leow, Alex/0000-0002-5660-8651
FU National Institutes of Health (NIH) through the NIH Roadmap for Medical
   Research [U54 RR021813]; National Center for Research Resources (NCRR)
   of the NIH [P41 RR013642, M01 RR000865]; National Alliance for Autism
   Research (NAAR) [01082668]; National Institute of Mental Health (NIMH)
   [5K08 MH01385, MH067187]; National Institute of Neurological Disorders
   and Stroke (NINDS) [5R01 NS046018, NS32070]; National Institute of
   Biomedical Imaging and Bioengineering (NIBIB) [R01 EB007813, R01
   EB008281, R01 EB008432]; National Institute of Child Health and Human
   Development (NICHHD) [R01 HD050735]; National Institute on Aging (NIA)
   [R01 AG020098]
FX Contract grant sponsor: National Institutes of Health (NIH) through the
   NIH Roadmap for Medical Research; Contract grant number: U54 RR021813;
   Contract grant sponsor: National Center for Research Resources (NCRR), a
   component of the NIH; Contract grant number: P41 RR013642 and M01
   RR000865; Contract grant sponsor: National Alliance for Autism Research
   (NAAR); Contract grant number: grants 01082668; Contract grant sponsor:
   National Institute of Mental Health (NIMH); Contract grant number: 5K08
   MH01385 and MH067187; Contract grant sponsor: National Institute of
   Neurological Disorders and Stroke (NINDS); Contract grant number: 5R01
   NS046018 and NS32070; Contract grant sponsor: National Institute of
   Biomedical Imaging and Bioengineering (NIBIB); Contract grant number:
   R01 EB007813, R01 EB008281, R01 EB008432; Contract grant sponsor:
   National Institute of Child Health and Human Development (NICHHD);
   Contract grant number: R01 HD050735; Contract grant sponsor: National
   Institute on Aging (NIA); Contract grant number: R01 AG020098.
CR Akshoomoff N, 2004, J AM ACAD CHILD PSY, V43, P349, DOI 10.1097/01.chi.0000103176.13414.67
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Ashburner J, 2003, MORPHOMETRY HUMAN BR, P707
   Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
   Brambilla P, 2003, BRAIN RES BULL, V61, P557, DOI 10.1016/j.brainresbull.2003.06.001
   Brito AR, 2009, J NEUROIMAGING, V19, P337, DOI 10.1111/j.1552-6569.2009.00366.x
   Carper RA, 2000, BRAIN, V123, P836, DOI 10.1093/brain/123.4.836
   Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   CDC (Cent. Dis. Control Prev.), 2009, MMWR-MORBID MORTAL W, V58, P1
   Chung MK, 2001, NEUROIMAGE, V14, P595, DOI 10.1006/nimg.2001.0862
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
   Courchesne E, 2004, CURR OPIN NEUROL, V17, P489, DOI 10.1097/01.wco.0000137542.14610.b4
   Courchesne E, 2004, MENT RETARD DEV D R, V10, P106, DOI 10.1002/mrdd.20020
   Efron B, 1986, STAT SCI, V1, P54, DOI DOI 10.1214/SS/1177013815
   Efron B., 1993, INTRO BOOTSTRAP
   Eliez S, 2000, J CHILD PSYCHOL PSYC, V41, P679, DOI 10.1017/S0021963099006095
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Freeborough PA, 1998, J COMPUT ASSIST TOMO, V22, P838, DOI 10.1097/00004728-199809000-00031
   Frith U., 1989, AUTISM EXPLAINING EN
   Giedd JN, 1999, NAT NEUROSCI, V2, P861, DOI 10.1038/13158
   Gogtay N, 2004, P NATL ACAD SCI USA, V101, P8174, DOI 10.1073/pnas.0402680101
   Gogtay N, 2008, P NATL ACAD SCI USA, V105, P15979, DOI 10.1073/pnas.0806485105
   Good CD, 2001, NEUROIMAGE, V14, P21, DOI 10.1006/nimg.2001.0786
   Hardan AY, 2009, BIOL PSYCHIAT, V66, P320, DOI 10.1016/j.biopsych.2009.04.024
   Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
   Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110
   Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032
   Hodge SM, 2010, J AUTISM DEV DISORD, V40, P300, DOI 10.1007/s10803-009-0872-7
   Hua X, 2008, NEUROIMAGE, V41, P19, DOI 10.1016/j.neuroimage.2008.02.010
   Hua X, 2008, NEUROIMAGE, V43, P458, DOI 10.1016/j.neuroimage.2008.07.013
   Hua X, 2010, NEUROBIOL AGING, V31, P1463, DOI 10.1016/j.neurobiolaging.2010.04.033
   Hua X, 2009, HUM BRAIN MAPP, V30, P209, DOI 10.1002/hbm.20498
   Hyde KL, 2010, HUM BRAIN MAPP, V31, P556, DOI 10.1002/hbm.20887
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kanner L, 1943, NERV CHILD, V2, P217
   Kates WR, 2004, AM J PSYCHIAT, V161, P539, DOI 10.1176/appi.ajp.161.3.539
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Kaufmann WE, 2003, J CHILD NEUROL, V18, P463, DOI 10.1177/08830738030180070501
   Knickmeyer RC, 2008, J NEUROSCI, V28, P12176, DOI 10.1523/JNEUROSCI.3479-08.2008
   Kochunov P, 2005, HUM BRAIN MAPP, V24, P325, DOI 10.1002/hbm.20090
   Kochunov P, 2002, NEUROIMAGE, V17, P922, DOI 10.1006/nimg.2002.1084
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Kovacevic N, 2005, CEREB CORTEX, V15, P639, DOI 10.1093/cercor/bhh165
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   Leow A, 2005, LECT NOTES COMPUT SC, V3565, P493
   Leow AD, 2006, NEUROIMAGE, V31, P627, DOI 10.1016/j.neuroimage.2005.12.013
   Levitt JG, 1999, PROG NEURO-PSYCHOPH, V23, P625, DOI 10.1016/S0278-5846(99)00021-4
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X
   Maes F, 1997, IEEE T MED IMAGING, V16, P187, DOI 10.1109/42.563664
   Mazziotta J, 2001, PHILOS T R SOC B, V356, P1293
   Mori S., 2005, MRI ATLAS HUMAN WHIT
   Morra JH, 2008, NEUROIMAGE, V43, P59, DOI 10.1016/j.neuroimage.2008.07.003
   Nichols TE, 2002, HUM BRAIN MAPP, V15, P1, DOI 10.1002/hbm.1058
   Piven J, 1996, J AM ACAD CHILD PSY, V35, P530, DOI 10.1097/00004583-199604000-00020
   PIVEN J, 1995, AM J PSYCHIAT, V152, P1145
   Rex DE, 2003, NEUROIMAGE, V19, P1033, DOI 10.1016/S1053-8119(03)00185-X
   Riddle WR, 2004, MAGN RESON IMAGING, V22, P769, DOI 10.1016/j.mri.2004.01.078
   Scott JA, 2009, AUTISM RES, V2, P246, DOI 10.1002/aur.97
   Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
   Shattuck DW, 2002, MED IMAGE ANAL, V6, P129, DOI 10.1016/S1361-8415(02)00054-3
   Sivaswamy L, 2010, J CHILD NEUROL, V25, P1223, DOI 10.1177/0883073809358765
   Sled JG, 1998, IEEE T MED IMAGING, V17, P87, DOI 10.1109/42.668698
   Sowell ER, 2004, J NEUROSCI, V24, P8223, DOI 10.1523/JNEUROSCI.1798-04.2004
   Sowell ER, 1999, NEUROIMAGE, V9, P587, DOI 10.1006/nimg.1999.0436
   Sparks BF, 2002, NEUROLOGY, V59, P184
   STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
   Thompson PM, 2000, NATURE, V404, P190
   Toga A. W., 1999, BRAIN WARPING, P385
   Webb SJ, 2009, PSYCHIAT RES-NEUROIM, V172, P61, DOI 10.1016/j.pscychresns.2008.06.001
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   Wells W M 3rd, 1996, Med Image Anal, V1, P35, DOI 10.1016/S1361-8415(96)80004-1
   Wilke M, 2002, HUM BRAIN MAPP, V17, P48, DOI 10.1002/hbm.10053
   Wilke M, 2008, NEUROIMAGE, V41, P903, DOI 10.1016/j.neuroimage.2008.02.056
   Woods RP, 1998, J COMPUT ASSIST TOMO, V22, P153, DOI 10.1097/00004728-199801000-00028
NR 84
TC 8
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD FEB
PY 2013
VL 34
IS 2
BP 425
EP 436
DI 10.1002/hbm.21441
PG 12
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
   Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 064ZM
UT WOS:000313115000015
PM 22021093
ER

PT J
AU Kataoka, S
   Takuma, K
   Hara, Y
   Maeda, Y
   Ago, Y
   Matsuda, T
AF Kataoka, Shunsuke
   Takuma, Kazuhiro
   Hara, Yuta
   Maeda, Yuko
   Ago, Yukio
   Matsuda, Toshio
TI Autism-like behaviours with transient histone hyperacetylation in mice
   treated prenatally with valproic acid
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Animal model; apoptosis; autism spectrum disorders; histone acetylation;
   valproate
ID CEREBRAL-CORTEX; ANTIEPILEPTIC DRUGS; SPECTRUM DISORDERS; MEMORY
   FORMATION; MOUSE MODELS; ANIMAL-MODEL; NEURONS; CELLS; MIGRATION; RATS
AB Maternal use of valproic acid (VPA) during pregnancy has been implicated in the aetiology of autism spectrum disorders in children, and rodents prenatally exposed to VPA showed behavioural alterations similar to those observed in humans with autism. However, the exact mechanism for VPA-induced behavioural alterations is not known. To study this point, we examined the effects of prenatal exposure to VPA and valpromide, a VPA analog lacking histone deacetylase inhibition activity, on behaviours, cortical pathology and histone acetylation levels in mice. Mice exposed to VPA at embryonic day 12.5 (E12.5), but not at E9 and E14.5, displayed social interaction deficits, anxiety-like behaviour and memory deficits at age 4-8 wk. In contrast to male mice, the social interaction deficits (a decrease in sniffing behaviour) were not observed in female mice at age 8 wk. The exposure to VPA at E12.5 decreased the number of Nissl-positive cells in the middle and lower layers of the prefrontal cortex and in the lower layers of the somatosensory cortex at age 8 wk. Furthermore, VPA exposure caused a transient increase in acetylated histone levels in the embryonic brain, followed by an increase in apoptotic cell death in the neocortex and a decrease in cell proliferation in the ganglionic eminence. In contrast, prenatal exposure to valpromide at E12.5 did not affect the behavioural, biochemical and histological parameters. Furthermore, these findings suggest that VPA-induced histone hyperacetylation plays a key role in cortical pathology and abnormal autism-like behaviours in mice.
C1 [Kataoka, Shunsuke; Takuma, Kazuhiro; Hara, Yuta; Maeda, Yuko; Ago, Yukio; Matsuda, Toshio] Osaka Univ, Lab Med Pharmacol, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan.
   [Matsuda, Toshio] Kanazawa Univ, Osaka Univ, United Grad Sch Child Dev, Osaka, Japan.
   [Matsuda, Toshio] Hamamatsu Univ Sch Med, Osaka, Japan.
RP Matsuda, T (reprint author), Osaka Univ, Lab Med Pharmacol, Grad Sch Pharmaceut Sci, 1-6 Yamadaoka, Suita, Osaka 5650871, Japan.
EM matsuda@phs.osaka-u.ac.jp
FU Japan Society for the Promotion
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research from the Japan Society for the Promotion.
CR Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6
   Bechara A, 2000, BRAIN, V123, P2189, DOI 10.1093/brain/123.11.2189
   Blaheta RA, 2002, MED RES REV, V22, P492, DOI 10.1002/med.10017
   Chwang WB, 2007, J NEUROSCI, V27, P12732, DOI 10.1523/JNEUROSCI.2522-07.2007
   Coleman M, 1978, AUTISM REAPPRAISAL C, P185
   Courchesne E, 1997, CURR OPIN NEUROBIOL, V7, P269, DOI 10.1016/S0959-4388(97)80016-5
   Downing C, 2010, TOXICOL SCI, V116, P632, DOI 10.1093/toxsci/kfq140
   Dragunow M, 2006, NEUROSCIENCE, V140, P1149, DOI 10.1016/j.neuroscience.2006.02.065
   Eadie MJ, 2008, EXPERT OPIN DRUG SAF, V7, P195, DOI 10.1517/14740338.7.2.195 
   Eikel D, 2006, DRUG METAB DISPOS, V34, P612, DOI 10.1124/dmd.105.008078
   Franklin K.B.J., 2001, MOUSE BRAIN STEREOTA
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Gould TD, 2004, MOL PSYCHIATR, V9, P734, DOI 10.1038/sj.mp.4001518
   Hashimoto M, 2004, J NEUROSCI, V24, P286, DOI 10.1523/JNEUROSCI.2529-03.2004
   Henry Thomas R, 2003, Psychopharmacol Bull, V37 Suppl 2, P5
   Hrebackova J, 2010, CURR DRUG TARGETS, V11, P361
   Hrubec TC, 2006, ANAT REC PART A, V288A, P1303, DOI 10.1002/ar.a.20397
   Ingram JL, 2000, NEUROTOXICOL TERATOL, V22, P319, DOI 10.1016/S0892-0362(99)00083-5
   Jung GA, 2008, BMC CELL BIOL, V9, DOI 10.1186/1471-2121-9-66
   Kazantsev AG, 2008, NAT REV DRUG DISCOV, V7, P854, DOI 10.1038/nrd2681
   Kim KC, 2011, TOXICOL LETT, V201, P137, DOI 10.1016/j.toxlet.2010.12.018
   Kwan P, 2001, PHARMACOL THERAPEUT, V90, P21, DOI 10.1016/S0163-7258(01)00122-X
   Lagger G, 2002, EMBO J, V21, P2672, DOI 10.1093/emboj/21.11.2672
   Lee CT, 2011, SYNAPSE, V65, P21, DOI 10.1002/syn.20814
   Levenson JM, 2004, J BIOL CHEM, V279, P40545, DOI 10.1074/jbc.M402229200
   Mantamadiotis T, 2002, NAT GENET, V31, P47, DOI 10.1038/ng882
   Marin O, 2001, NAT REV NEUROSCI, V2, P780, DOI 10.1038/35097509
   Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
   Molyneaux BJ, 2007, NAT REV NEUROSCI, V8, P427, DOI 10.1038/nrn2151
   Moore SJ, 2000, J MED GENET, V37, P489, DOI 10.1136/jmg.37.7.489
   Moy SS, 2006, AM J MED GENET C, V142C, P40, DOI 10.1002/ajmg.c.30081
   NISHIKAWA T, 1985, BRAIN RES, V331, P81, DOI 10.1016/0006-8993(85)90717-6
   Ornoy A, 2009, REPROD TOXICOL, V28, P1, DOI 10.1016/j.reprotox.2009.02.014
   Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
   Phiel CJ, 2001, J BIOL CHEM, V276, P36734, DOI 10.1074/jbc.M101287200
   Rocchi P, 2005, ONCOL REP, V13, P1139
   Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
   Roullet FI, 2010, NEUROSCIENCE, V170, P514, DOI 10.1016/j.neuroscience.2010.06.069
   Schneider T, 2006, NEUROPSYCHOPHARMACOL, V31, P36, DOI 10.1038/sj.npp.1300767
   Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
   Shabbeer S, 2007, PROSTATE, V67, P1099, DOI 10.1002/pros.20587
   Shinozaki K, 2002, DEVELOPMENT, V129, P3479
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Stigler KA, 2011, BRAIN RES, V1380, P146, DOI 10.1016/j.brainres.2010.11.076
   Takuma K, 2007, NEUROSCIENCE, V146, P60, DOI 10.1016/j.neuroscience.2007.01.017
   Tung EWY, 2010, TOXICOL APPL PHARM, V248, P201, DOI 10.1016/j.taap.2010.08.001
   van Kooten IAJ, 2008, BRAIN, V131, P987, DOI 10.1093/brain/awn033
   Wagner GC, 2006, J AUTISM DEV DISORD, V36, P779, DOI 10.1007/s10803-006-0117-y
   Wang L, 2003, P NATL ACAD SCI USA, V100, P703, DOI 10.1073/pnas.242735799
   Williams G, 2001, DEV MED CHILD NEUROL, V43, P202, DOI 10.1017/S001216220100038X
   Williams PG, 1997, DEV MED CHILD NEUROL, V39, P632
   Wing L., 1976, EARLY CHILDHOOD AUTI
NR 52
TC 20
Z9 21
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1461-1457
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD FEB
PY 2013
VL 16
IS 1
BP 91
EP 103
DI 10.1017/S1461145711001714
PG 13
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 058TX
UT WOS:000312658300009
PM 22093185
ER

PT J
AU Kiani, R
   Tyrer, F
   Hodgson, A
   Berkin, N
   Bhaumik, S
AF Kiani, R.
   Tyrer, F.
   Hodgson, A.
   Berkin, N.
   Bhaumik, S.
TI Urban-rural differences in the nature and prevalence of mental
   ill-health in adults with intellectual disabilities
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE city-county differences; intellectual disability; mental ill-health;
   psychiatric disorders; urbanisation; urban-rural differences
ID NATIONAL MORBIDITY SURVEY; PSYCHIATRIC-DISORDERS; RISK-FACTORS; MAJOR
   DEPRESSION; GREAT-BRITAIN; FOLLOW-UP; COMMUNITY; SCHIZOPHRENIA;
   URBANIZATION; PEOPLE
AB Background In the general population there are statistically significant urbanrural differences in the rate of common mental disorders. In people with intellectual disability (ID) no study has attempted to address this issue. Aims To compare the prevalence of mental illness, autism spectrum disorder (ASD) and behaviour disorder in people with ID living in urban areas with those living in rural areas. Methods Cross-sectional study of 2713 individuals registered with an ID service. Participants were assigned to urban or rural groups using the Department for Environment Food and Rural Affairs rural/urban local authority classification for their district. The main outcome variable was a clinical diagnosis of mental illness, ASD and behaviour disorder. Differences between diagnoses of mental illness in urban and rural areas were evaluated using the chi-squared test for the difference in two independent proportions. Results No differences were observed between gender, age and level of ID of service users based on their place of residence. But more people from an ethnic minority background were living in urban areas than rural areas. No differences were observed in the overall prevalence of mental illness by place of residence. However, the results showed that ASD was more common in people living in rural areas. Conclusions We found these results surprising and at odds with the majority of studies carried out in the general population and propose several reasons for the differences found. We believe that the results and further studies in this area will help inform health service provision for those with ID who live in different geographical areas.
C1 [Kiani, R.] Leicestershire Partnership NHS Trust, Learning Disabil Serv, Agnes Unit, Leicester LE7 7GL, Leics, England.
   [Tyrer, F.; Hodgson, A.; Bhaumik, S.] Univ Leicester, Leicester, Leics, England.
RP Kiani, R (reprint author), Leicestershire Partnership NHS Trust, Learning Disabil Serv, Agnes Unit, 400 Anstey Lane, Leicester LE7 7GL, Leics, England.
EM reza.kiani@leicspart.nhs.uk
CR Australian Institute of Health and Welfare, 1998, HLTH RUR REM AUSTR
   Bhaumik S, 2008, J INTELL DISABIL RES, V52, P986, DOI 10.1111/j.1365-2788.2008.01124.x
   BLAZER D, 1985, ARCH GEN PSYCHIAT, V42, P651
   BLAZER DG, 1994, AM J PSYCHIAT, V151, P979
   Boardman AP, 1997, BRIT J PSYCHIAT, V171, P457, DOI 10.1192/bjp.171.5.457
   British Medical Association Board of Science, 2005, HEALTHC RUR SETT
   Cooper SA, 2007, BRIT J PSYCHIAT, V190, P27, DOI 10.1192/bjp.bp.106.022483
   CROWELL BA, 1986, BRIT J PSYCHIAT, V149, P307, DOI 10.1192/bjp.149.3.307
   Dekker J, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-17
   Department for Environment Food and Rural Affairs, 2005, DEFR CLASS LOC AUTH
   Eckert KA, 2004, MED J AUSTRALIA, V181, P540
   Faris REL, 1939, MENTAL DISORDERS URB
   Gething L, 1997, DISABIL SOC, V12, P513, DOI 10.1080/09687599727100
   Goldberg A.J., 1993, PSYCHIAT CARE MED PA, P87
   HARDING L, 1992, J OCCUP ORGAN PSYCH, V65, P269
   Judd FK, 2002, AUST NZ J PSYCHIAT, V36, P104, DOI 10.1046/j.1440-1614.2002.00986.x
   LEE CK, 1990, J NERV MENT DIS, V178, P247, DOI 10.1097/00005053-199004000-00005
   LEWIS G, 1992, LANCET, V340, P137, DOI 10.1016/0140-6736(92)93213-7
   Lorant V, 2003, AM J EPIDEMIOL, V157, P98, DOI 10.1093/aje/kwf182
   MCGROTHER CW, 1993, J PUBLIC HEALTH MED, V15, P263
   Najim H, 2005, PSYCHIAT B, V29, P13, DOI 10.1192/pb.29.1.13
   National Statistics, 2001, CENS TABL LEIC LEIC
   NEFF JA, 1987, J COMMUNITY PSYCHOL, V15, P520, DOI 10.1002/1520-6629(198710)15:4<520::AID-JCOP2290150410>3.0.CO;2-0
   NEFF JA, 1985, J HEALTH SOC BEHAV, V26, P207, DOI 10.2307/2136753
   Nicholson LA, 2008, ADV PSYCHIAT TREATME, V14, P302, DOI DOI 10.1192/APT.BP.107.005009
   ONS Geography, 2004, ALL FIELDS POSTC DIR
   Parikh SV, 1996, J AFFECT DISORDERS, V38, P57, DOI 10.1016/0165-0327(95)00096-8
   Paykel E, 2003, INT REV PSYCHIATR, V15, P97, DOI 10.1080/0954026021000046001
   Paykel ES, 2000, PSYCHOL MED, V30, P269, DOI 10.1017/S003329179900183X
   Pedersen CB, 2001, BRIT J PSYCHIAT, V179, P46, DOI 10.1192/bjp.179.1.46
   Peters J., 2005, IMPACT RURALITY HLTH
   ROMANSCLARKSON SE, 1990, BRIT J PSYCHIAT, V156, P84, DOI 10.1192/bjp.156.1.84
   Royal College of Psychiatrist, 2001, OP48 ROYAL COLL PSYC
   SEIVEWRIGHT H, 1991, PSYCHOL MED, V21, P495
   Smiley E, 2007, BRIT J PSYCHIAT, V191, P313, DOI 10.1192/bjp.bp.106.031104
   SPARROW SS, 1985, J PEDIATR PSYCHOL, V10, P215, DOI 10.1093/jpepsy/10.2.215
   Sundquist K, 2004, BRIT J PSYCHIAT, V184, P293, DOI 10.1192/bjp.184.4.293
   Tyrer F, 2008, J APPL RES INTELLECT, V21, P268, DOI 10.1111/j.1468-3148.2007.00409.x
   van Os J, 2001, ARCH GEN PSYCHIAT, V58, P663, DOI 10.1001/archpsyc.58.7.663
   Verheij RA, 1996, SOC SCI MED, V42, P923, DOI 10.1016/0277-9536(95)00190-5
   Weich S, 2003, J EPIDEMIOL COMMUN H, V57, P616, DOI 10.1136/jech.57.8.616
   Weich S, 2006, BRIT J PSYCHIAT, V188, P51, DOI 10.1192/bjp.bp.105.008714
   Weich S, 1998, BRIT MED J, V317, P115
NR 43
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD FEB
PY 2013
VL 57
IS 2
SI SI
BP 119
EP 127
DI 10.1111/j.1365-2788.2011.01523.x
PG 9
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA 064ZG
UT WOS:000313114200002
PM 22292906
ER

PT J
AU Felce, D
   Kerr, M
AF Felce, D.
   Kerr, M.
TI Investigating low adaptive behaviour and presence of the triad of
   impairments characteristic of autistic spectrum disorder as indicators
   of risk for challenging behaviour among adults with intellectual
   disabilities
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE challenging behaviour; intellectual disabilities; risk indicators
ID SELF-INJURIOUS-BEHAVIOR; PHYSICAL INTERVENTIONS; AGGRESSIVE-BEHAVIOR;
   TOTAL POPULATION; STAFF WORKING; PREVALENCE; PEOPLE; CHILDREN;
   PSYCHOPATHOLOGY; PERSISTENCE
AB Background Identification of possible personal indicators of risk for challenging behaviour has generally been through association in cross-sectional prevalence studies, but few analyses have controlled for intercorrelation between potential risk factors. The aim was to investigate the extent to which gender, age, presence of the triad of impairments characteristic of autism and level of adaptive behaviour were independently associated with level of challenging behaviour among adults with intellectual disabilities. Methods Five datasets were merged to produce information on challenging behaviour, adaptive behaviour, presence of the triad of impairments, gender and age of 818 adults. Variables were entered into a multivariate linear regression, which also tested the interaction between the presence of the triad of impairments and level of adaptive behaviour. Results Presence of the triad of impairments, level of adaptive behaviour, their interaction, and age, but not gender, significantly and independently contributed to the prediction of challenging behaviour. Presence/absence of the triad of impairments moderated the effect of adaptive behaviour on challenging behaviour. The inverse relationship found in the absence of the triad of impairments was virtually removed when present. Conclusions This study has shown that it is necessary to control for intercorrelation between potential risk factors for challenging behaviour and to explore how interaction between them might moderate associations.
C1 [Felce, D.; Kerr, M.] Cardiff Univ, Sch Med, Welsh Ctr Learning Disabil, Cardiff CF14 4YS, S Glam, Wales.
RP Felce, D (reprint author), Cardiff Univ, Sch Med, Welsh Ctr Learning Disabil, Hlth Pk, Cardiff CF14 4YS, S Glam, Wales.
EM felce@cf.ac.uk
CR Aiken L, 1991, MULTIPLE REGRESSION
   Allen D, 2006, J APPL RES INTELLECT, V19, P356, DOI 10.1111/j.1468-3148.2005.00292.x
   Allen DG, 2007, J INTELL DISABIL RES, V51, P409, DOI 10.1111/j.1365-2788.2006.00877.x
   Aman M., 1986, ABERRANT BEHAV CHECK
   Baxter H, 2006, BRIT J GEN PRACT, V56, P93
   Borthwick-Duffy S. A., 1994, DESTRUCTIVE BEHAV DE, P3
   Cooper SA, 2009, J INTELL DISABIL RES, V53, P217, DOI 10.1111/j.1365-2788.2008.01127.x
   Cooper SA, 2009, J INTELL DISABIL RES, V53, P200, DOI 10.1111/j.1365-2788.2008.01060.x
   Crocker AG, 2006, J INTELL DISABIL RES, V50, P652, DOI 10.1111/j.1365-2788.2006.00815.x
   Dykens EM, 2000, J CHILD PSYCHOL PSYC, V41, P407, DOI 10.1017/S0021963000005667
   Emerson E, 2001, RES DEV DISABIL, V22, P77, DOI 10.1016/S0891-4222(00)00061-5
   Emerson E, 2000, J APPL RES INTELLECT, V13, P197, DOI 10.1046/j.1468-3148.2000.00036.x
   Emerson E., 2008, COMMISSIONING PERSON
   Emerson E, 2001, RES DEV DISABIL, V22, P67, DOI 10.1016/S0891-4222(00)00062-7
   Emerson E, 2001, CHALLENGING BEHAV AN
   Felce D, 2009, J INTELL DISABIL RES, V53, P243, DOI 10.1111/j.1365-2788.2008.01131.x
   Felce D, 2003, AM J MENT RETARD, V108, P161, DOI 10.1352/0895-8017(2003)108<0161:RRAPRA>2.0.CO;2
   Felce D, 2002, J APPL RES INTELLECT, V15, P404, DOI 10.1046/j.1468-3148.2002.00131.x
   FREUND LS, 1991, RES DEV DISABIL, V12, P435, DOI 10.1016/0891-4222(91)90037-S
   Hastings RP, 2002, J INTELLECT DEV DIS, V27, P149, DOI 10.1080/1366825021000008657
   Hawkins S, 2005, J APPL RES INTELLECT, V18, P19, DOI 10.1111/j.1468-3148.2004.00207.x
   Holden B, 2006, RES DEV DISABIL, V27, P456, DOI 10.1016/j.ridd.2005.06.001
   HOLMES N, 1982, PSYCHOL MED, V12, P879
   Jenkins R, 1997, J INTELL DISABIL RES, V41, P502, DOI 10.1111/j.1365-2788.1997.tb00743.x
   Jones E, 2001, J APPL RES INTELLECT, V14, P79, DOI 10.1046/j.1468-3148.2001.00064.x
   Kiernan C., 1997, EXPERIENCES VIEWS PA
   Kiernan C, 1996, J APPL RES INTELLECT, V9, P181
   Lowe K, 2007, J INTELL DISABIL RES, V51, P625, DOI 10.1111/j.1365-2788.2006.00948.x
   Matson JL, 2008, RES DEV DISABIL, V29, P141, DOI 10.1016/j.ridd.2007.02.001
   McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
   Melville CA, 2008, J AUTISM DEV DISORD, V38, P1676, DOI 10.1007/s10803-008-0549-7
   Mitchell G, 2001, AM J MENT RETARD, V106, P448, DOI 10.1352/0895-8017(2001)106<0448:CBAEIS>2.0.CO;2
   Mohr C, 2005, J INTELL DISABIL RES, V49, P469, DOI 10.1111/j.1365-2788.2005.00701.x
   Morgan C. N., 2002, PSYCHIAT B, V26, P127, DOI 10.1192/pb.26.4.127
   Nihira K., 1993, ADAPTIVE BEHAV SCALE
   Perry J, 2005, AM J MENT RETARD, V110, P121, DOI 10.1352/0895-8017(2005)110<121:FAWOIC>2.0.CO;2
   Qureshi H., 1992, MENT HANDICAP RES, V5, P130
   Rojahn J, 2003, RES DEV DISABIL, V24, P391, DOI 10.1016/S0891-4222(03)00055-6
   Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
   Tyrer F, 2006, J INTELL DISABIL RES, V50, P295, DOI 10.1111/j.1365-2788.2005.00774.x
   WATERHOUSE L, 1992, J AUTISM DEV DISORD, V22, P525, DOI 10.1007/BF01046326
   Windahl S.I., 1988, 8 C INT ASS SCI STUD
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
   Wing Lorna, 1988, DIAGNOSIS ASSESSMENT, P91
NR 44
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD FEB
PY 2013
VL 57
IS 2
SI SI
BP 128
EP 138
DI 10.1111/j.1365-2788.2011.01524.x
PG 11
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA 064ZG
UT WOS:000313114200003
PM 22292930
ER

PT J
AU Khanna, R
   Jariwala, K
   West-Strum, D
AF Khanna, R.
   Jariwala, K.
   West-Strum, D.
TI Use and cost of psychotropic drugs among recipients with autism in a
   state Medicaid fee-for-service programme
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE autism; costs; Medicaid; psychotropic drugs
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; CHILDREN;
   PREVALENCE; INDIVIDUALS; DIAGNOSIS; SYMPTOMS; CARE
AB Background There has been a significant increase in the prevalence of autism in the USA in the past few decades. The purpose of this study was to provide recent estimates of psychotropic drug use and costs among individuals with autism enrolled in Medicaid programme. Method A cross-sectional analysis of 2007 Mississippi (MS) Medicaid fee-for-service (FFS) programme administrative-claims data was performed. Study sample included recipients (<65 years) who had a medical services claim with a diagnosis of autism in 2007. Psychotropic drug patterns of use and costs were studied. Factors predicting the use of psychotropic drugs were identified using logistic regression analyses. Average number and cost of psychotropic drug claims per recipient were reported. Costs were reported from the perspective of MS Medicaid. Results In 2007, there were 1330 recipients with a diagnosis of autism in MS Medicaid FFS programme. Among these recipients, 66.32% had a claim for psychotropic drug during the year. Roughly 39% of recipients with autism had a claim for antipsychotics, 31.58% for stimulants, 19.55% for antidepressants, 19.40% for other psychotropics and 14.81% for anxiolytics/hypnotics/sedatives. Results from regression analyses highlighted variation in psychotropic drug use by demographic and co-morbid factors. There were a total of 12 618 claims for psychotropic drugs filled by recipients with autism in 2007, at an average of 14 (+/- 12) claims per recipient. The total cost of these claims paid for by MS Medicaid FFS programme was similar to$2 million. Antipsychotics accounted for more than half (similar to 58%) of the total costs, and had the highest average cost per claim ($291 +/- 205). Conclusions The results of this study indicate a high use of psychotropic drugs among individuals with autism enrolled in a state Medicaid programme. There is an urgent need to study the riskbenefit profile of these drugs in this growing population. Psychotropic drug use was found to vary by demographic and co-morbid factors. Among the different classes of psychotropic drugs, antipsychotics were the most commonly used and had the highest cost per claim.
C1 [Khanna, R.; Jariwala, K.; West-Strum, D.] Univ Mississippi, Sch Pharm, University, MS 38677 USA.
RP Khanna, R (reprint author), Univ Mississippi, Sch Pharm, Faser Hall 236,POB 1848, University, MS 38677 USA.
EM rkhanna@olemiss.edu
CR Aman MG, 2005, J CLIN PSYCHIAT, V66, P38
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
   Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P1339, DOI 10.1007/s10803-009-0750-3
   Findling RL, 2005, J CLIN PSYCHIAT, V66, P26
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   GILLBERG C, 1981, J AUTISM DEV DISORD, V11, P365
   Holburn CS, 2008, INTELLECT DEV DISAB, V46, P243, DOI 10.1352/2008.46:243-246
   Jacobson J, 1998, BEHAV INTERVENT, V13, P201, DOI DOI 10.1002/(SICI)1099-078X
   Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
   Kutcher S.P., 1997, PSYCHOPHARMACOLOGIC
   Langworthy-Lam KS, 2002, J CHILD ADOL PSYCHOP, V12, P311, DOI 10.1089/104454602762599853
   Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
   Mandell DS, 2008, PEDIATRICS, V121, pE441, DOI 10.1542/peds.2007-0984
   Mayes SD, 1999, INFANT YOUNG CHILD, V12, P90
   McPheeters ML, 2011, PEDIATRICS, V127, pE1312, DOI 10.1542/peds.2011-0427
   Nicholas JS, 2008, ANN EPIDEMIOL, V18, P130, DOI 10.1016/i.annepidem.2007.10.013
   Oswald DP, 2007, J CHILD ADOL PSYCHOP, V17, P348, DOI 10.1089/cap.2006.17303
   Périsse Didier, 2010, J Can Acad Child Adolesc Psychiatry, V19, P100
   Posey DJ, 2008, J CLIN INVEST, V118, P6, DOI 10.1172/JCI32483
   Rosenberg RE, 2010, J AUTISM DEV DISORD, V40, P342, DOI 10.1007/s10803-009-0878-1
   Rubin DM, 2009, PEDIATRICS, V124, pE305, DOI 10.1542/peds.2008-3713
   Ruble LA, 2005, J AUTISM DEV DISORD, V35, P3, DOI 10.1007/s10803-004-1026-6
   Szpir M, 2006, ENVIRON HEALTH PERSP, V114, pA412
   Tsai LY, 1999, PSYCHOSOM MED, V61, P651
NR 25
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD FEB
PY 2013
VL 57
IS 2
SI SI
BP 161
EP 171
DI 10.1111/j.1365-2788.2012.01563.x
PG 11
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA 064ZG
UT WOS:000313114200006
PM 22471524
ER

PT J
AU Bigham, K
   Daley, DM
   Hastings, RP
   Jones, RSP
AF Bigham, K.
   Daley, D. M.
   Hastings, R. P.
   Jones, R. S. P.
TI Association between parent reports of attention deficit hyperactivity
   disorder behaviours and child impulsivity in children with severe
   intellectual disability
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE ADHD; Cookie Delay Task; hyperactivity; impulsivity; intellectual
   disability
ID DIFFICULTIES QUESTIONNAIRE; MENTAL-RETARDATION; ADHD; SYMPTOMS;
   STRENGTHS; AUTISM; SCALES
AB Background Although children with intellectual disability (ID) seemed to be at increased risk for Attention deficit hyperactivity disorder (ADHD)/hyperactivity problems when assessed with parent report questionnaires and clinical interviews, there has been little attention to the associations between parent reports and observed child behaviours. The purpose of the present study was to compare clinical symptoms and observed impulsivity in children with ID whose parents reported them as being relatively high and low in ADHD symptoms, and to examine whether any differences were associated with developmental level. Methods Parents of 28 children with ID completed a behaviour rating scale of hyperactivity symptoms. Parents were also interviewed using a robust clinical interview tool focused on hyperactivity symptoms. The children were all tested by an experimenter to measure their impulsive behaviour. Results Those children with clinical range scores on parent questionnaire ratings were also reported by parents to have more ADHD symptoms using a parent report clinical interview. Although these children were also more impulsive on an experimental task, when children's developmental ages were statistically controlled impulsivity differences disappeared. Conclusions Parent reports of ADHD symptoms in children with ID may be positively associated with data derived using clinical interview methods, but they may be less sensitive to developmental expectations when compared with observed child behaviour. Practical implications include the need for multiple sources of information and normative data for children with ID on simple experimental tasks that can be used to aid diagnosis of ADHD in clinical settings.
C1 [Bigham, K.; Hastings, R. P.; Jones, R. S. P.] Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
   [Bigham, K.; Jones, R. S. P.] Betsi Cadwaladr Univ Hlth Board, Bangor, Gwynedd, Wales.
   [Daley, D. M.] Univ Nottingham, Sch Community Hlth Sci, Nottingham NG7 2RD, England.
RP Hastings, RP (reprint author), Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
EM r.hastings@bangor.ac.uk
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
CR Achenbach TM, 1991, MANUAL CHILD BEHAV C
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Baker BL, 2010, J CLIN CHILD ADOLESC, V39, P492, DOI 10.1080/15374416.2010.486321
   Beck A, 2004, J INTELLECT DEV DIS, V29, P339, DOI 10.1080/13668250400014509
   CAMPBELL SB, 1982, J ABNORM CHILD PSYCH, V10, P569, DOI 10.1007/BF00920755
   Carter AS, 1998, J AUTISM DEV DISORD, V28, P287, DOI 10.1023/A:1026056518470
   Dekker MC, 2003, J AM ACAD CHILD PSY, V42, P915, DOI 10.1097/01.CHI.0000046892.27264.1A
   Elander J, 1996, INT J METHOD PSYCH, V6, P63, DOI 10.1002/(SICI)1234-988X(199607)6:2<63::AID-MPR151>3.3.CO;2-M
   Emerson C, 2007, BRIT J PSYCHIAT, V191, P439
   FEE VE, 1994, RES DEV DISABIL, V15, P67, DOI 10.1016/0891-4222(94)90039-6
   Goodman R, 1999, J ABNORM CHILD PSYCH, V27, P17, DOI 10.1023/A:1022658222914
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Handen BL, 1998, J ABNORM CHILD PSYCH, V26, P269, DOI 10.1023/A:1022654417460
   Handen BL, 2007, J DEV PHYS DISABIL, V19, P579, DOI 10.1007/s10882-007-9071-7
   Hastings RP, 2005, RES DEV DISABIL, V26, P456, DOI 10.1016/j.ridd.2004.10.003
   Pearson DA, 1996, AM J MENT RETARD, V100, P592
   Simonoff E, 2007, J AM ACAD CHILD PSY, V46, P591, DOI 10.1097/chi.0b013e3180323330
   Sonuga-Barke EJS, 2003, J AM ACAD CHILD PSY, V42, P1335, DOI 10.1097/01.chi.0000087564.34977.21
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Taylor E., 2006, ATTENTION DEFICIT HY, P3, DOI 10.1016/B978-0-7506-7574-1.50008-6
   Taylor E, 1991, EPIDEMIOLOGY CHILDHO
   Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
NR 22
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD FEB
PY 2013
VL 57
IS 2
SI SI
BP 191
EP 197
DI 10.1111/j.1365-2788.2011.01522.x
PG 7
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA 064ZG
UT WOS:000313114200009
PM 22292862
ER

PT J
AU Vonk, J
   Zeigler-Hill, V
   Mayhew, P
   Mercer, S
AF Vonk, Jennifer
   Zeigler-Hill, Virgil
   Mayhew, Patricia
   Mercer, Sterett
TI Mirror, mirror on the wall, which form of narcissist knows self and
   others best of all?
SO PERSONALITY AND INDIVIDUAL DIFFERENCES
LA English
DT Article
DE Narcissism; Perspective-taking; Empathy; Causal-reasoning; Emotional
   intelligence
ID HIGH-FUNCTIONING AUTISM; NORMAL SEX-DIFFERENCES; ASPERGER-SYNDROME;
   PATHOLOGICAL NARCISSISM; EMOTIONAL INTELLIGENCE; PERSONALITY-INVENTORY;
   ADULTS; MIND; EMPATHY; VALIDATION
AB We examined the relationships of narcissism and its various facets with measures of cognition, such as perspective-taking/theory of mind, emotional intelligence, empathy, and systemizing, in a non-clinical sample of 368 undergraduate students. Social and physical causal reasoning was assessed using a novel procedure, which allowed for a thorough examination of participants' attributions of causes to social and non-social events. Results revealed that individuals high in grandiosity scored higher on measures of social reasoning, emotional intelligence, perspective-taking, systemizing, and empathy. Other facets of narcissism, as well as the overall construct of narcissism, were negatively associated with emotional intelligence, empathy, and perspective-taking. These results suggest that the facets of narcissism may differ considerably in their associations with various aspects of social cognition, which should prompt researchers to further examine the heterogeneous nature of narcissism. Published by Elsevier Ltd.
C1 [Vonk, Jennifer] Oakland Univ, Dept Psychol, Rochester, MI 48309 USA.
   [Mayhew, Patricia] Univ So Mississippi, Hattiesburg, MS 39406 USA.
   [Mercer, Sterett] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
RP Vonk, J (reprint author), Oakland Univ, Dept Psychol, 2200 N Squirrel Rd, Rochester, MI 48309 USA.
EM vonk@oakland.edu
CR Ackerman RA, 2011, ASSESSMENT, V18, P67, DOI 10.1177/1073191110382845
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Ames DR, 2004, J NONVERBAL BEHAV, V28, P187, DOI 10.1023/B:JONB.0000039649.20015.0e
   Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Besser A, 2010, J RES PERS, V44, P520, DOI 10.1016/j.jrp.2010.06.006
   Brown RP, 2009, PERS SOC PSYCHOL B, V35, P951, DOI 10.1177/0146167209335461
   Campbell W. K., 2006, INTRAPERSONAL PROCES
   Chen FF, 2012, J PERS, V80, P219, DOI 10.1111/j.1467-6494.2011.00739.x
   COSTANZO M, 1989, J NONVERBAL BEHAV, V13, P225, DOI 10.1007/BF00990295
   DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
   Ghorbani N, 2010, CURR PSYCHOL, V29, P135, DOI 10.1007/s12144-010-9079-5
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   Houlcroft L, 2012, PERS INDIV DIFFER, V53, P274, DOI 10.1016/j.paid.2012.03.036
   Maxwell K, 2011, PERS INDIV DIFFER, V50, P577, DOI 10.1016/j.paid.2010.11.031
   Morf CC, 2001, PSYCHOL INQ, V12, P177, DOI 10.1207/S15327965PLI1204_1
   Muthen L. K., 2010, MPLUS USERS GUIDE
   Petrides KV, 2011, TWIN RES HUM GENET, V14, P35, DOI 10.1375/twin.14.1.35
   Pincus AL, 2009, PSYCHOL ASSESSMENT, V21, P365, DOI 10.1037/a0016530
   Pincus AL, 2010, ANNU REV CLIN PSYCHO, V6, P421, DOI 10.1146/annurev.clinpsy.121208.131215
   PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
   RASKIN RN, 1979, PSYCHOL REP, V45, P590
   Schutte NS, 1998, PERS INDIV DIFFER, V25, P167, DOI 10.1016/S0191-8869(98)00001-4
   Tamborski M, 2012, PERS INDIV DIFFER, V52, P942, DOI 10.1016/j.paid.2012.01.030
   Wai M, 2012, PERS INDIV DIFFER, V52, P794, DOI 10.1016/j.paid.2012.01.008
   WATSON PJ, 1992, J PERS DISORD, V6, P434
NR 29
TC 4
Z9 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0191-8869
J9 PERS INDIV DIFFER
JI Pers. Individ. Differ.
PD FEB
PY 2013
VL 54
IS 3
BP 396
EP 401
DI 10.1016/j.paid.2012.10.010
PG 6
WC Psychology, Social
SC Psychology
GA 062MV
UT WOS:000312924800014
ER

PT J
AU Monahan, M
   Classen, S
   Helsel, PV
AF Monahan, Miriam
   Classen, Sherrilene
   Helsel, Patty V.
TI Pre-driving evaluation of a teen with attention deficit hyperactivity
   disorder and autism spectrum disorder
SO CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE
LA English
DT Article
DE Adolescents; Attention-deficit disorder with hyperactivity; Automobile
   driving; Pervasive disorders
ID DEFICIT/HYPERACTIVITY DISORDER; PERFORMANCE; CHILDREN; ADULTS
AB Background. Vehicle crashes are the leading cause of death among teens, and those teens with attention-deficit/hyperactivity disorder and autism spectrum disorder (ADHD/ASD) may have a greater crash risk. Purpose. This case study compared the pre-driving skills of a teen with ADHD/ASD to an age-and gender-matched healthy control (HC). Method. Data were collected from performance on clinical tests and on a driving simulator. Findings. The main impairments of the teen with ADHD/ASD were the ability to shift attention, perform simple sequential tasks, integrate visual-motor responses, and coordinate motor responses, whereas the HC demonstrated intact skills in these abilities. The teen with ADHD/ASD made 44 driving errors during the drive, and the HC made 17. The teen with ADHD/ASD had more lane maintenance, visual scanning, and speeding errors compared to the HC. Implications. Teens with ADHD/ASD may have more pre-driving deficits and may require a certified driving rehabilitation specialist to assess readiness to drive, but a larger study is needed to confirm this.
C1 [Monahan, Miriam] Univ Florida, Coll Publ Hlth & Hlth Profess, Inst Mobil Act & Participat, Dept Occupat Therapy, Gainesville, FL 32610 USA.
   [Classen, Sherrilene] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Occupat Therapy, Gainesville, FL 32610 USA.
   [Classen, Sherrilene] Univ Florida, Coll Publ Hlth & Hlth Profess, Inst Mobil Act & Participat, Gainesville, FL 32610 USA.
   [Helsel, Patty V.] Shands Rehab Ctr Kids Magnolia Parke, Gainesville, FL 32606 USA.
RP Classen, S (reprint author), Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Occupat Therapy, POB 100164, Gainesville, FL 32610 USA.
EM sclassen@phhp.ufl.edu
FU University of Florida and Shands
FX This study received funding from the 2011-2012 University of Florida and
   Shands.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Barkley RA, 2004, PSYCHIAT CLIN N AM, V27, P233, DOI 10.1016/S0193-953X(03)00091-1
   Beery K, 2010, BEERY BUKTENICA DEV
   Bruininks R. H., 2005, BRUININKS OSERETSKY
   Centers for Disease Control and Prevention, 2008, TEEN DRIV FACT SHEET
   Centers for Disease Control and Prevention, 2012, DAT STAT AUT SPECTR
   Visser S. N., 2010, Morbidity and Mortality Weekly Report, V59, P1439
   Classen S, 2010, AM J OCCUP THER, V64, P211
   Classen S., TRAFFIC INJ IN PRESS
   Edwards JD, 2005, AGING MENT HEALTH, V9, P262, DOI 10.1080/13607860412331336788
   Fisk GD, 2002, J HEAD TRAUMA REHAB, V17, P16
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Huang P, 2012, J DEV BEHAV PEDIATR, V33, P70, DOI 10.1097/DBP.0b013e31823a43b7
   Jerome Laurence, 2006, J Can Acad Child Adolesc Psychiatry, V15, P105
   Justiss MD, 2006, TOP GERIATR REHABIL, V22, P121
   Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
   National Institute of Mental Health, 2011, WHAT IS AUT SPECTR D
   National Institute of Mental Health, 2011, ATT DEF HYP DIS ADHD
   Reynolds CR, 2002, COMPREHENSIVE TRAIL
   Sergeant JA, 2002, BEHAV BRAIN RES, V130, P3, DOI 10.1016/S0166-4328(01)00430-2
   Smith A., 1993, SYMBOL DIGIT MODALIT
NR 21
TC 1
Z9 1
PU CANADIAN ASSOC OCCUPATIONAL THERAPISTS
PI OTTAWA
PA CTTC BLDG, 3400-1125 COLONEL BY DRIVE, OTTAWA, ONTARIO K1S 5R1, CANADA
SN 0008-4174
EI 1911-9828
J9 CAN J OCCUP THER
JI Can. J. Occup. Ther.
PD FEB
PY 2013
VL 80
IS 1
BP 35
EP 41
DI 10.1177/0008417412474221
PG 7
WC Rehabilitation
SC Rehabilitation
GA 302HS
UT WOS:000330595300006
PM 23550495
ER

PT J
AU Armstrong, K
   Kimonis, ER
AF Armstrong, Kathleen
   Kimonis, Eva R.
TI Parent-Child Interaction Therapy for the Treatment of Asperger's
   Disorder in Early Childhood: A Case Study
SO CLINICAL CASE STUDIES
LA English
DT Article
DE parent training; Asperger's disorder; PCIT
ID DISRUPTIVE BEHAVIOR; EARLY INTERVENTION; YOUNG-CHILDREN; ADOLESCENTS;
   AUTISM; SPECTRUM; FAMILIES; TRIAL; MODEL
AB Almost half of all children diagnosed with Asperger's disorder (ASP) present with comorbid behavioral difficulties associated with attention deficit/hyperactivity disorder, oppositional defiant disorder, conduct disorder, obsessive-compulsive disorder, and generalized anxiety disorders. Children with ASP often are noncompliant, aggressive, and difficult for parents to manage, which may prevent these children from participating in school and community activities, thus contributing to reduced opportunities for development of important skills. Finding effective interventions to treat these behavioral issues remains a clinical priority to improve overall outcomes for these children. This case study presents the treatment of a 5-year-old boy with ASP and severe behavior problems using Parent-Child Interaction Therapy, an empirically supported behavioral parenting intervention developed for young children with disruptive behavior disorders. Findings from this case report documented (a) an improvement in behavioral functioning that was maintained at follow-up and (b) provided support for utilizing this evidenced-based treatment to improve functioning of young children with ASP and comorbid disruptive behavior disorders.
C1 [Armstrong, Kathleen; Kimonis, Eva R.] Univ S Florida, Tampa, FL USA.
RP Armstrong, K (reprint author), Childrens Med Serv, 13101 N Bruce B Downs Blvd, Tampa, FL 33612 USA.
EM karmstro@health.usf.edu
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bagner DM, 2007, J CLIN CHILD ADOLESC, V36, P418
   Brereton AV, 2006, J AUTISM DEV DISORD, V36, P863, DOI 10.1007/s10803-006-0125-y
   Brinkmeyer MY, 2003, EVIDENCE-BASED PSYCHOTHERAPIES FOR CHILDREN AND ADOLESCENTS, P204
   Brookman-Frazee L, 2009, APPLIED BEHAVIOR ANALYSIS FOR CHILDREN WITH AUTISM SPECTRUM DISORDERS, P237, DOI 10.1007/978-1-4419-0088-3_14
   Butter EM, 2006, BEHAV INTERVENT, V21, P227, DOI 10.1002/bin.225
   Center for Autism and Developmental Disabilities Epidemiology, 2012, FACT SHEET
   Centers for Disease Control and Prevention (CDC), 2012, AUT SPECTR DIS ASDS
   Chaflant A. M., 2007, J AUTISM DEV DISORD, V37, P1842
   Cohen H, 2006, J DEV BEHAV PEDIATR, V27, P145, DOI DOI 10.1097/00004703-200604002-00013
   Eyberg S., 2011, PARENT CHILD INTERAC
   Eyberg S. M., 2004, MANUAL PARENT CHILD
   Eyberg S. M., 2005, ED TREATMENT CHILDRE, V28, P197
   EYBERG SM, 1995, PSYCHOPHARMACOL BULL, V31, P83
   Eyberg SM, 2008, J CLIN CHILD ADOLESC, V37, P215, DOI 10.1080/15374410701820117
   Farbotko M., 2002, AUTISM, V8, P301
   Fombonne E, 2005, UNDERSTANDING AUTISM, P25
   Gadow KD, 2004, J AUTISM DEV DISORD, V34, P379, DOI 10.1023/B:JADD.0000037415.21458.93
   Gale B. M., 2010, STEPPED ARE E HLTH P, P181
   Gillberg C., 1991, AUTISM ASPERGER SYND, P122, DOI 10.1017/CBO9780511526770.004
   Gilliam J., 2001, GILLIAM ASPERGERS DI
   Goldstein S., 2010, AUTISM SPECTRUM RATI
   Harrison P., 2003, ADAPTIVE BEHAV ASSES, V2nd
   Horner R. H., 2002, J AUTISM DEV DISORD, V32, P339
   Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
   Kochanska G, 2002, DEV PSYCHOL, V38, P339, DOI 10.1037//0012-1649.38.3.399
   Lecavalier L., 2008, J AUTISM DEV DISORD, V17, P149
   Lord C, 2012, AUTISM DIAGNOSTIC OB, V2
   McIntosh DE, 2000, PSYCHOL SCHOOLS, V37, P453, DOI 10.1002/1520-6807(200009)37:5<453::AID-PITS5>3.0.CO;2-2
   Pincus D., 1999, EYBERG CHILD BEHAV I
   Scahill L., 2007, CLIN MANUAL TREATMEN, P131
   Schapiro M. L., 2007, CLIN MANUAL TREATMEN, P51
   Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
   Solomon M, 2008, J AUTISM DEV DISORD, V38, P1767, DOI 10.1007/s10803-008-0567-5
   Steinmetz S., 2009, J AUTISM DEV DISORD, V39, P976
   Tonge B. J., 1999, AUTISM, V3, P117, DOI DOI 10.1177/1362361399003002003
   U. S. Department of Education, 2004, INDIVIDUALS DISABILI
   van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
   Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
NR 40
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-6501
EI 1552-3802
J9 CLIN CASE STUD
JI Clin. Case Stud.
PD FEB
PY 2013
VL 12
IS 1
BP 60
EP 72
DI 10.1177/1534650112463429
PG 13
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA AW9OL
UT WOS:000346586800004
ER

PT J
AU Boudreau, J
   Harvey, MT
AF Boudreau, Jordan
   Harvey, Mark T.
TI Increasing Recreational Initiations for Children Who Have ASD Using
   Video Self Modeling
SO EDUCATION AND TREATMENT OF CHILDREN
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; OF-THE-LITERATURE; SOCIAL-SKILLS;
   INTERVENTION; PERSPECTIVE; INSTRUCTION; STUDENTS; ADULTS
AB The current study examined the effects of video self modeling (VSM) on social initiations using a multiple baseline across participants experimental design. Three students with Autism Spectrum Disorders (ASD) watched videos of themselves engaged in typical, age appropriate social initiations prior to playtime with a triad of peers. A partial interval recording system was used to measure social initiations of students with ASD and typically developing peers. The percentage of intervals during which students with ASD exhibited play initiations increased to levels comparable to typically developing peers for all three participants. Two students with ASD demonstrated elevated levels of initiations during a maintenance probe conducted two weeks post-intervention. The efficiency of using VSM within a social skills curriculum, limitations of the current study, and future directions for VSM are discussed.
C1 [Boudreau, Jordan; Harvey, Mark T.] Florida Inst Technol, Melbourne, FL 32901 USA.
RP Harvey, MT (reprint author), Florida Inst Technol, Dept Psychol, 150 W Univ Ave, Melbourne, FL 32901 USA.
EM mharvey@fit.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Ayres KM, 2005, EDUC TRAIN DEV DISAB, V40, P183
   Bandura A, 2001, ANNU REV PSYCHOL, V52, P1, DOI 10.1146/annurev.psych.52.1.1
   Bellini S, 2007, EXCEPT CHILDREN, V73, P264
   Buggey T., 2005, FOCUS AUTISM OTHER D, V20, P52, DOI DOI 10.1177/10883576050200010501
   Buggey T., 1999, J POSIT BEHAV INTERV, V1, P205, DOI 10.1177/109830079900100403
   Charlop M. H., 2010, ED TREATMENT CHILDRE, V33, P371, DOI DOI 10.1353/ETC.0.0104
   CHARLOP MH, 1989, J APPL BEHAV ANAL, V22, P275, DOI 10.1901/jaba.1989.22-275
   Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
   Charlop-Christy MH, 2003, J POSIT BEHAV INTERV, V5, P12, DOI 10.1177/10983007030050010101
   Dowrick P. W., 1986, SOCIAL SURVIVAL CHIL
   Dowrick PW, 1999, APPL PREV PSYCHOL, V8, P23, DOI 10.1016/S0962-1849(99)80009-2
   GRESHAM FM, 1982, EXCEPT CHILDREN, V48, P422
   Hauck M, 1995, J AUTISM DEV DISORD, V25, P579, DOI 10.1007/BF02178189
   Hobson RP, 1998, J AUTISM DEV DISORD, V28, P117, DOI 10.1023/A:1026088531558
   Hume K, 2005, TOP EARLY CHILD SPEC, V25, P195, DOI 10.1177/02711214050250040101
   Kanner L, 1943, NERV CHILD, V2, P217
   McArthur D, 1996, J AUTISM DEV DISORD, V26, P481, DOI 10.1007/BF02172271
   Miklich D. R., 1974, SELF MODELING BEHAV
   Nikopoulos CK, 2003, BEHAV INTERVENT, V18, P87, DOI 10.1002/bin.129
   Nikopoulos CK, 2004, J APPL BEHAV ANAL, V37, P93, DOI 10.1901/jaba.2004.37-93
   Njardvik U, 1999, J AUTISM DEV DISORD, V29, P287, DOI 10.1023/A:1022107318500
   Odom SL, 2005, EXCEPT CHILDREN, V71, P137
   Shukla-Mehta S, 2010, FOCUS AUTISM DEV DIS, V25, P23, DOI 10.1177/1088357609352901
   WALKER HM, 1994, TOP LANG DISORD, V14, P70
   WILLIAMS SL, 1989, REM SPEC EDUC, V10, P18
NR 26
TC 3
Z9 3
PU WEST VIRGINIA UNIV PRESS
PI MORGANTOWN
PA COMMUNICATIONS BLDG PATTESON DR, PO BOX 6295, MORGANTOWN, WV 26506-6295
   USA
SN 0748-8491
EI 1934-8924
J9 EDUC TREAT CHILD
JI Educ. Treat. Child.
PD FEB
PY 2013
VL 36
IS 1
BP 49
EP 60
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AP0JG
UT WOS:000341747000003
ER

PT J
AU Esch, K
   Fryling, MJ
AF Esch, Kathleen
   Fryling, Mitch J.
TI A Comparison of Two Variations of the High-Probability Instructional
   Sequence with a Child with Autism
SO EDUCATION AND TREATMENT OF CHILDREN
LA English
DT Article
DE Autism; Compliance; High-Probability Instructional Sequence;
   Non-Compliance; Behavioral Momentum
ID INJURIOUS ESCAPE BEHAVIOR; EXTINCTION; MOMENTUM; INCREASE;
   NONCOMPLIANCE; DISABILITIES; ACCEPTANCE; FOOD
AB Children who engage in low rates of compliance can be at a, serious disadvantage relative to peers in important areas of learning, and also be at risk for more restrictive placements and long-term dependence on others more generally. One intervention, the high-probability (high-p) instructional sequence, has involved a variety of results. There is still much to learn about the mechanisms responsible for behavior change in high-p sequences. The present study compared two variations of the high-p sequence: maintenance and leisure high-p tasks, on the compliance of a young child with autism. Results indicated that compliance with low-p tasks was higher in the leisure high-p condition relative to the maintenance high-p condition across all three tasks. Implications for understanding the mechanisms responsible for behavior change in high-p sequences are provided.
C1 [Esch, Kathleen; Fryling, Mitch J.] Chicago Sch Profess Psychol, Chicago, IL 60654 USA.
RP Fryling, MJ (reprint author), Calif State Univ Los Angeles, Div Special Educ & Counseling, Charter Coll Educ, 5151 State Univ Dr, Los Angeles, CA 90032 USA.
EM Mitchell.Fryling2@calstatela.edu
CR Ardoin SP, 1999, J APPL BEHAV ANAL, V32, P339, DOI 10.1901/jaba.1999.32-339
   Bijou S. W., 1995, BEHAV ANAL CHILD DEV
   Bullock C, 2006, J APPL BEHAV ANAL, V39, P495, DOI 10.1901/jaba.2006.115-05
   Davis C. A., 2000, ED TREATMENT CHILDRE, V23, P423
   DAVIS CA, 1994, J APPL BEHAV ANAL, V27, P619, DOI 10.1901/jaba.1994.27-619
   Dawson JE, 2003, J APPL BEHAV ANAL, V36, P105, DOI 10.1901/jaba.2003.36-105
   Donohoe J. W., 2011, HDB APPL BEHAV ANAL, P17
   FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
   Kantor J. R., 1958, INTERBEHAVIORAL PSYC
   Mace FC, 1997, J APPL BEHAV ANAL, V30, P1, DOI 10.1901/jaba.1997.30-1
   MACE FC, 1990, J APPL BEHAV ANAL, V23, P507, DOI 10.1901/jaba.1990.23-507
   Meier AE, 2012, J APPL BEHAV ANAL, V45, P149, DOI 10.1901/jaba.2012.45-149
   Normand MP, 2010, J APPL BEHAV ANAL, V43, P735, DOI 10.1901/jaba.2010.43-735
   Patel M, 2007, BEHAV INTERVENT, V22, P305, DOI 10.1002/bin.251
   Patel MR, 2006, RES DEV DISABIL, V27, P430, DOI 10.1016/j.ridd.2005.05.005
   RORTVEDT AK, 1994, J APPL BEHAV ANAL, V27, P327, DOI 10.1901/jaba.1994.27-327
   Wilder D. A., 2011, TEACHING BEHAV SUPPO, P151
   Wilder DA, 2007, J APPL BEHAV ANAL, V40, P535, DOI 10.1901/jaba.2007.40-535
   ZARCONE JR, 1993, J APPL BEHAV ANAL, V26, P135, DOI 10.1901/jaba.1993.26-135
   ZARCONE JR, 1994, J APPL BEHAV ANAL, V27, P649, DOI 10.1901/jaba.1994.27-649
   Zuluaga CA, 2008, J APPL BEHAV ANAL, V41, P453, DOI 10.1901/jaba.2008.41-453
NR 21
TC 0
Z9 0
PU WEST VIRGINIA UNIV PRESS
PI MORGANTOWN
PA COMMUNICATIONS BLDG PATTESON DR, PO BOX 6295, MORGANTOWN, WV 26506-6295
   USA
SN 0748-8491
EI 1934-8924
J9 EDUC TREAT CHILD
JI Educ. Treat. Child.
PD FEB
PY 2013
VL 36
IS 1
BP 61
EP 72
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AP0JG
UT WOS:000341747000004
ER

PT J
AU Love, JR
   Carr, JE
   LeBlanc, LA
   Kisamore, AN
AF Love, Jessa R.
   Carr, James E.
   LeBlanc, Linda A.
   Kisamore, April N.
TI Training Behavioral Research Methods to Staff in an Early and Intensive
   Behavioral Intervention Setting: A Program Description and Preliminary
   Evaluation
SO EDUCATION AND TREATMENT OF CHILDREN
LA English
DT Article
DE Autism Treatment; Behavioral Skills Training; Early and Intensive
   Behavioral Intervention; Single-Case Design Research; Staff Training;
   Scientist-Practitioner Model
ID CHILDREN; AUTISM; SKILLS
AB The extensive clinical activity occurring in the area of early and intensive behavioral intervention (EIBI) for children with autism represents a promising opportunity to conduct research on clinically relevant problems and on effectiveness and efficiency of various procedures. However, many practitioners providing these services may not have received adequate training in conducting single-case design research in field settings. Training practitioners to implement such research has the potential to improve the use of the scientist-practitioner model in these settings and expand the base of scientific knowledge in this area. Through the current training program, we used a modified behavioral skills training (BST) approach to teach practitioners to prepare and implement single-case design research protocols in an applied setting. Participants were able to learn and apply a number of important research skills as evidenced by statistically significant improvements on six tests throughout training and high scores on homework assignments that required staff to engage in various research-related behaviors. The results are discussed in the context of preparing EIBI settings for greater research productivity.
C1 [Love, Jessa R.; Carr, James E.; LeBlanc, Linda A.; Kisamore, April N.] Western Michigan Univ, Kalamazoo, MI 49008 USA.
RP Love, JR (reprint author), Trumpet Behav Hlth, 2101 W Broadway,Suite 103 PMB118, Columbia, MO 65203 USA.
EM jlove@tbh.com
CR Carrell L. J., 2001, COMMUN EDUC, V50, P230
   Cooper J., 1987, APPL BEHAV ANAL
   Cooper J. O., 2007, APPL BEHAV ANAL
   Eldevik S, 2009, J CLIN CHILD ADOLESC, V38, P439, DOI 10.1080/15374410902851739
   Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
   Hayes S. C., 1999, SCI PRACTITIONER RES
   Ivar Lovaas O., 1987, J CONSULT CLIN PSYCH, V55, P3, DOI DOI 10.1037//0022-006X.55.13
   Kirkpatrick D. L., 1967, TRAINING DEV HDB, P87
   MCEACHIN JJ, 1993, AM J MENT RETARD, V97, P359
   Miltenberger R.G., 2004, BEHAV MODIFICATION P
   Perry A, 2008, RES AUTISM SPECT DIS, V2, P621, DOI 10.1016/j.rasd.2008.01.002
   Reid D. H., 2006, MOTIVATING HUMAN SER
   Sarokoff RA, 2004, J APPL BEHAV ANAL, V37, P535, DOI 10.1901/jaba.2004.37-535
   STRICKER G, 1995, AM PSYCHOL, V50, P995, DOI 10.1037/0003-066X.50.12.995
   White F., 2006, PSYCHOL LEARNING TEA, V5, P23
   Witmer L, 1996, AM PSYCHOL, V51, P248, DOI 10.1037//0003-066X.51.3.248
   Wood AL, 2007, BEHAV MODIF, V31, P847, DOI 10.1177/0145445507302893
NR 17
TC 0
Z9 0
PU WEST VIRGINIA UNIV PRESS
PI MORGANTOWN
PA COMMUNICATIONS BLDG PATTESON DR, PO BOX 6295, MORGANTOWN, WV 26506-6295
   USA
SN 0748-8491
EI 1934-8924
J9 EDUC TREAT CHILD
JI Educ. Treat. Child.
PD FEB
PY 2013
VL 36
IS 1
BP 139
EP 160
PG 22
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA AP0JG
UT WOS:000341747000008
ER

PT J
AU Ciaramelli, E
   Bernardi, F
   Moscovitch, M
AF Ciaramelli, Elisa
   Bernardi, Francesco
   Moscovitch, Morris
TI Individualized theory of mind (iToM): when memory modulates empathy
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE theory of mind; empathy; episodic memory; autobiographical memory;
   episodic simulation
ID HIGH-FUNCTIONING AUTISM; NARCISSISTIC PERSONALITY-DISORDER;
   AUTOBIOGRAPHICAL MEMORY; EPISODIC MEMORY; ASPERGER-SYNDROME;
   METACOGNITIVE CAPACITY; SOCIAL COGNITION; SELF-REFLECTION; BRAIN;
   SCHIZOPHRENIA
AB Functional neuroimaging studies have noted that brain regions supporting theory of mind (ToM) overlap remarkably with those underlying episodic memory, suggesting a link between the two processes. The present study shows that memory for others' past experiences modulates significantly our appraisal of, and reaction to, what is happening to them currently. Participants read the life story of two characters; one had experienced a long series of love-related failures, the other a long series of work-related failures. In a later faux pas recognition task, participants reported more empathy for the character unlucky in love in love-related faux pas scenarios, and for the character unlucky at work in work-related faux pas scenarios. The memory-based modulation of empathy correlated with the number of details remembered from the characters' life story. These results suggest that individuals use memory for other people's past experiences to simulate how they feel in similar situations they are currently facing. The integration of ToM and memory processes allows adjusting mental state inferences to fit unique social targets, constructing an individualized ToM.
C1 [Ciaramelli, Elisa] Univ Bologna, Dipartimento Psicol, I-40126 Bologna, Italy.
   [Ciaramelli, Elisa] Univ Bologna, Ctr Studi & Ric Neurosci Cognit, I-40126 Bologna, Italy.
   [Bernardi, Francesco; Moscovitch, Morris] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada.
   [Bernardi, Francesco] Northwestern Univ, Dept Psychol, Evanston, IL USA.
   [Moscovitch, Morris] Rotman Res Inst, Toronto, ON, Canada.
RP Ciaramelli, E (reprint author), Univ Bologna, Dipartimento Psicol, Viale Berti Pichat 5, I-40126 Bologna, Italy.
EM elisa.ciaramelli@unibo.it
CR Adler N, 2010, PSYCHIAT RES, V178, P214, DOI 10.1016/j.psychres.2009.11.015
   Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Batson D. C., 1996, PERS SOC PSYCHOL B, V22, P474
   Buckner RL, 2007, TRENDS COGN SCI, V11, P49, DOI 10.1016/j.tics.2006.11.004
   Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
   Rabin Jennifer S, 2012, Front Psychol, V3, P588, DOI 10.3389/fpsyg.2012.00588
   Ciaramelli E, 2012, J INT NEUROPSYCH SOC, V18, P962, DOI 10.1017/S1355617712000690
   Corcoran R, 2003, PSYCHOL MED, V33, P897, DOI 10.1017/S0033291703007529
   Davis M. H., 1980, JSAS CATALOG SELECTE, V10, P85
   de Vignemont F, 2006, TRENDS COGN SCI, V10, P435, DOI 10.1016/j.tics.2006.08.008
   de Waal FBM, 2008, ANNU REV PSYCHOL, V59, P279, DOI 10.1146/annurev.psych.59.103006.093625
   Dimaggio G, 2012, J CLIN PSYCHOL, V68, P922, DOI 10.1002/jclp.21896
   Dimaggio G, 2008, CONSCIOUS COGN, V17, P778, DOI 10.1016/j.concog.2008.02.005
   Dimaggio G, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00529
   Gallagher HL, 2003, TRENDS COGN SCI, V7, P77, DOI 10.1016/S1364-6613(02)00025-6
   Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
   Gilboa A, 2002, HDB MEMORY DISORDERS, P315
   Harrison BJ, 2007, SCHIZOPHR RES, V91, P82, DOI 10.1016/j.schres.2006.12.027
   Hassabis D, 2007, P NATL ACAD SCI USA, V104, P1726, DOI 10.1073/pnas.0610561104
   Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
   Krienen FM, 2010, J NEUROSCI, V30, P13906, DOI 10.1523/JNEUROSCI.2180-10.2010
   Lawson J, 2004, J AUTISM DEV DISORD, V34, P301, DOI 10.1023/B:JADD.0000029552.42724.1b
   Levine B, 1998, BRAIN, V121, P1951, DOI 10.1093/brain/121.10.1951
   Levine B, 2002, PSYCHOL AGING, V17, P677, DOI 10.1037//0882-7974.17.4.677
   Lieberman MD, 2001, PSYCHOL SCI, V12, P135, DOI 10.1111/1467-9280.00323
   Lysaker PH, 2007, PSYCHOTHER RES, V17, P713, DOI 10.1080/10503300701255932
   Lysaker PH, 2011, PSYCHOL PSYCHOTHER-T, V84, P58, DOI 10.1348/147608310X520436
   Martin A, 2001, CURR OPIN NEUROBIOL, V11, P194, DOI 10.1016/S0959-4388(00)00196-3
   Mitchell JP, 2006, NEURON, V50, P655, DOI 10.1016/j.neuron.2006.03.040
   Mitchell JP, 2009, PHILOS T R SOC B, V364, P1309, DOI 10.1098/rstb.2008.0318
   PERNER J, 1995, J EXP CHILD PSYCHOL, V59, P516, DOI 10.1006/jecp.1995.1024
   Perry D, 2011, NEUROIMAGE, V54, P1669, DOI 10.1016/j.neuroimage.2010.08.057
   Preston SD, 2002, BEHAV BRAIN SCI, V25, P1
   Rabin JS, 2010, J COGNITIVE NEUROSCI, V22, P1095, DOI 10.1162/jocn.2009.21344
   Rabin JS, 2012, NEUROIMAGE, V62, P520, DOI 10.1016/j.neuroimage.2012.05.002
   Rabin JS, 2012, NEUROPSYCHOLOGIA, V50, P3781, DOI 10.1016/j.neuropsychologia.2012.10.016
   Race E, 2011, J NEUROSCI, V31, P10262, DOI 10.1523/JNEUROSCI.1145-11.2011
   Ritter K, 2011, PSYCHIAT RES, V187, P241, DOI 10.1016/j.psychres.2010.09.013
   Rosenbaum RS, 2007, SCIENCE, V318, P1257, DOI 10.1126/science.1148763
   Rosenbaum RS, 2005, NEUROPSYCHOLOGIA, V43, P989, DOI 10.1016/j.neuropsychologia.2004.10.007
   Schacter DL, 2008, ANN NY ACAD SCI, V1124, P39, DOI 10.1196/annals.1440.001
   Shamay-Tsoory SG, 2009, BRAIN, V132, P617, DOI 10.1093/brain/awn279
   Shamay-Tsoory SG, 2005, COGN BEHAV NEUROL, V18, P55, DOI 10.1097/01.wnn.0000152228.90129.99
   Sheldon S, 2011, NEUROPSYCHOLOGIA, V49, P2439, DOI 10.1016/j.neuropsychologia.2011.04.021
   Singer T, 2009, ANN NY ACAD SCI, V1156, P81, DOI 10.1111/j.1749-6632.2009.04418.x
   Spreng RN, 2010, J COGNITIVE NEUROSCI, V22, P1112, DOI 10.1162/jocn.2009.21282
   Spreng RN, 2012, BRAIN RES, V1428, P43, DOI 10.1016/j.brainres.2010.12.024
   Squire LR, 2010, P NATL ACAD SCI USA, V107, P19044, DOI 10.1073/pnas.1014391107
   STINSON L, 1992, J PERS SOC PSYCHOL, V62, P787, DOI 10.1037//0022-3514.62.5.787
   St Jacques PL, 2011, J COGNITIVE NEUROSCI, V23, P1275, DOI 10.1162/jocn.2010.21518
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   Stuss DT, 2001, BRAIN, V124, P279, DOI 10.1093/brain/124.2.279
   TULVING E, 1985, CAN PSYCHOL, V26, P1, DOI 10.1037/h0080017
   Wagner DD, 2011, CEREB CORTEX, V21, P2788, DOI 10.1093/cercor/bhr074
   Wechsler D., 1987, WECHSLER MEMORY SCAL
   Zaki J, 2008, PSYCHOL SCI, V19, P399, DOI 10.1111/j.1467-9280.2008.02099.x
   Zaki J, 2012, NAT NEUROSCI, V15, P675, DOI 10.1038/nn.3085
NR 59
TC 5
Z9 5
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD FEB 1
PY 2013
VL 4
AR 4
DI 10.3389/fpsyg.2013.00004
PG 18
WC Psychology, Multidisciplinary
SC Psychology
GA AA0KK
UT WOS:000330783800001
PM 23378839
ER

PT J
AU Maddox, LL
   Marvin, CA
AF Maddox, Laura L.
   Marvin, Christine A.
TI A Preliminary Evaluation of a Statewide Professional Development Program
   on Autism Spectrum Disorders
SO TEACHER EDUCATION AND SPECIAL EDUCATION
LA English
DT Article
DE autism; professional development; mentoring; evaluation
AB Training and technical assistance programs for autism spectrum disorders (ASD) have emerged in many states as educators, administrators, and institutions of higher education attempt to address the increasing needs for enhancing the knowledge and skills of educators and disseminating the ever-growing knowledge of educational practices. This report provides data from an evaluation study of a professional development effort conducted by a state-sponsored autism spectrum disorders network. Results documented the positive impact of an 18-month, mentored professional development experience for school-based professionals throughout the state. Surveys of trainees' knowledge before and after training indicated shifts in their confidence, from basic knowledge of ASD characteristics and practices to confidence in their ability to implement ASD-related practices. In addition, mentors documented increased use of ASD practices in trainees' classrooms using a checklist of ASD evidence-based practices.
C1 [Maddox, Laura L.] Lincoln Publ Sch, Early Childhood Special Educ Personnel Programmin, Lincoln, NE 68501 USA.
   [Marvin, Christine A.] Univ Nebraska Lincoln, Dept Special Educ & Commun Disorders, Lincoln, NE USA.
RP Maddox, LL (reprint author), Lincoln Publ Sch, POB 82889, Lincoln, NE 68501 USA.
EM lmaddox@lps.org
CR Bandura A., 1994, ENCY HUMAN BEHAV, V4, P71
   Barnhill GP, 2011, FOCUS AUTISM DEV DIS, V26, P75, DOI 10.1177/1088357610378292
   Dow M. J., 2001, AUTISM SPECTRUM DISO, P89
   Dunst CJ, 2009, INFANT YOUNG CHILD, V22, P164
   Joyce B., 2002, STUDENT ACHIEVEMENT, V3rd
   Kincaid D., 2003, FOCUS AUTISM OTHER D, V18, P150, DOI DOI 10.1177/10883576030180030301
   Lehrman D. C., 2004, J APPL BEHAV ANAL, V37, P11
   Lord C., 2001, DIVISION BEHAV SOCIA, P183
   McCabe H., 2008, TEACHER ED SPECIAL E, V31, P103, DOI 10.1177/088840640803100204
   Muller E., 2006, FORUM BRIEF POLICY A
   National Professional Development Center on Autism Spectrum Disorders, WHAT AR EV BAS PRACT
   National Staff Development Council, 2001, NSDCS STAND STAFF DE
   Ohio Center for Autism and Low Incidence, 2011, NAT AUT LEAD SUMM
   Scheuermann B., 2003, FOCUS AUTISM OTHER D, V18, P197, DOI DOI 10.1177/10883576030180030801
   Simpson RL, 2004, EXCEPT CHILDREN, V70, P135
   Strain PS, 2011, TOP EARLY CHILD SPEC, V31, P133, DOI 10.1177/0271121411408740
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
NR 17
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0888-4064
EI 1944-4931
J9 TEACH EDUC SPEC EDUC
JI Teach. Educ. Spec. Educ.
PD FEB
PY 2013
VL 36
IS 1
BP 37
EP 50
DI 10.1177/0888406412463827
PG 14
WC Education & Educational Research
SC Education & Educational Research
GA V38YO
UT WOS:000209378900004
ER

PT J
AU Ferretti, F
   Cosentino, E
AF Ferretti, Francesco
   Cosentino, Erica
TI Time, language and flexibility of the mind: The role of mental time
   travel in linguistic comprehension and production
SO PHILOSOPHICAL PSYCHOLOGY
LA English
DT Article
DE Adaptive Equilibrium; Cognitive Evolution; Descartes' Problem;
   Flexibility; Mental Time Travel; Speech Flux
ID BRAINS DEFAULT NETWORK; EPISODIC SIMULATION; STORY COMPREHENSION; MEMORY
   IMPAIRMENT; SPATIAL LANGUAGE; SCHIZOPHRENIA; FUTURE; COMMUNICATION;
   AUTISM; COGNITION
AB According to Chomsky, creativity is a critical property of human language, particularly the aspect of the creative use of language concerning the appropriateness to a situation. How language can be creative but appropriate to a situation is an unsolvable mystery from the Chomskyan point of view. We propose that language appropriateness can be explained by considering the role of the human capacity for Mental Time Travel at its foundation, together with social and ecological intelligences within a triadic language-grounding system. Our proposal is based on the change of perspective from the analysis of individual sentences to the flux of speech in which the temporal dimension of language is much more relevant.
C1 [Ferretti, Francesco] Univ Roma Tre, Dept Philosophy, I-00144 Rome, Italy.
   [Cosentino, Erica] Univ Roma Tor Vergata, Dept Philosoph Res, I-00173 Rome, Italy.
RP Ferretti, F (reprint author), Univ Roma Tre, Dept Philosophy, Via Ostiense 234, I-00144 Rome, Italy.
EM fferretti@uniroma3.it
CR Addis DR, 2009, NEUROPSYCHOLOGIA, V47, P2222, DOI 10.1016/j.neuropsychologia.2008.10.026
   Aleman A, 1999, AM J PSYCHIAT, V156, P1358
   ANDREASEN NC, 1979, ARCH GEN PSYCHIAT, V36, P1325
   Andreasen NC, 1985, CONTROVERSIES SCHIZO, P199
   Andrews-Hanna JR, 2010, NEURON, V65, P550, DOI 10.1016/j.neuron.2010.02.005
   ardenfors P., 2010, EVOLUTION HUMAN LANG, P103
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Barsalou LW, 2008, ANNU REV PSYCHOL, V59, P617, DOI 10.1146/annurev.psych.59.103006.093639
   Bickerton D., 1996, LANGUAGE HUMAN BEHAV
   Bloom P., 1996, LANGUAGE SPACE
   Buckner RL, 2007, TRENDS COGN SCI, V11, P49, DOI 10.1016/j.tics.2006.11.004
   Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
   Busby-Grant J, 2009, EUR J DEV PSYCHOL, V6, P746, DOI 10.1080/17405620802102947
   Carruthers P., 2006, ARCHITECTURE MIND MA
   Casasanto D, 2008, COGNITION, V106, P579, DOI 10.1016/j.cognition.2007.03.004
   Chaika E. O., 1990, UNDERSTANDING PSYCHO
   Chomsky Noam, 1988, LANGUAGE PROBLEMS KN
   Christiansen MH, 2008, BEHAV BRAIN SCI, V31, P489, DOI 10.1017/S0140525X08004998
   COHEN BD, 1976, ANN NY ACAD SCI, V270, P124, DOI 10.1111/j.1749-6632.1976.tb34218.x
   Corballis M. C., 2007, WHAT MAKES US HUMAN, P17
   Corballis MC, 2009, EXP BRAIN RES, V192, P553, DOI 10.1007/s00221-008-1491-9
   Cosentino E, 2011, CONSCIOUS COGN, V20, P777, DOI 10.1016/j.concog.2010.12.006
   Covington MA, 2005, SCHIZOPHR RES, V77, P85, DOI 10.1016/j.schres.2005.01.016
   Damasio A., 1994, DESCARTES ERROR EMOT
   Danion JM, 2007, CAN J PSYCHIAT, V52, P693
   Danion JM, 2007, CAMB HANDB PSYCHOL, P481
   Danion J-M., REMEMBERING EN UNPUB
   D'Argembeau A, 2008, J ABNORM PSYCHOL, V117, P247, DOI 10.1037/0021-843X.117.1.247
   Davis GA, 1997, BRAIN LANG, V56, P183
   Descartes R., 2002, DISCOURSE METHOD RIG
   Doherty Martin J., 2008, THEORY MIND CHILDREN
   Eans Dylan, 2001, EMOTION SCI SENTIMEN
   FLETCHER PC, 1995, COGNITION, V57, P109, DOI 10.1016/0010-0277(95)00692-R
   Fodor J.A., 1983, MODULARITY MIND ESSA
   Frijda N. H., 1986, EMOTIONS
   Frith C., 1992, COGNITIVE NEUROPSYCH
   FRITH U, 1989, BRIT J DISORD COMMUN, V24, P123
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   Gibbs R.W., 1994, POETICS MIND
   Goldman A., 2006, SIMULATING MINDS PHI
   Grice Paul, 1957, PHILOS REV, V66, P377, DOI DOI 10.2307/2182440
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   HAPPE FGE, 1993, COGNITION, V48, P101, DOI 10.1016/0010-0277(93)90026-R
   HAPPE FGE, 1995, METAPHOR SYMB ACT, V10, P275, DOI 10.1207/s15327868ms1004_3
   Hassabis D, 2007, P NATL ACAD SCI USA, V104, P1726, DOI 10.1073/pnas.0610561104
   Hopper Paul J., 2003, GRAMMATICALIZATION, V2nd
   Hurford J.R., 2007, ORIGINS MEANING LANG
   Kelso J. A. S., 1995, DYNAMIC PATTERNS SEL
   Klein SB, 2002, SOC COGNITION, V20, P353, DOI 10.1521/soco.20.5.353.21125
   Lakusta L, 2010, P NATL ACAD SCI USA, V107, P2813, DOI 10.1073/pnas.0909155107
   LANDAU B, 1993, BEHAV BRAIN SCI, V16, P217
   Landau B, 2003, DEV NEUROPSYCHOL, V23, P105, DOI 10.1207/S15326942DN231&2_6
   Landau B., 2002, ENCY HUMAN BRAIN, V4, P395
   Mar RA, 2011, ANNU REV PSYCHOL, V62, P103, DOI 10.1146/annurev-psych-120709-145406
   Marini A, 2008, SCHIZOPHR RES, V105, P144, DOI 10.1016/j.schres.2008.07.011
   Marini A, 2010, J NEUROLINGUIST, V23, P97, DOI 10.1016/j.jneuroling.2009.10.002
   McCormack T, 1999, DEV REV, V19, P154, DOI 10.1006/drev.1998.0476
   MCGRATH J, 1991, BRIT J PSYCHIAT, V158, P307, DOI 10.1192/bjp.158.3.307
   Mulcahy NJ, 2006, SCIENCE, V312, P1038, DOI 10.1126/science.1125456
   Neumann A, 2007, CAN J PSYCHIAT, V52, P450
   Noveck IA, 2004, PALG STUD PRAGM LANG, P1, DOI 10.1057/9780230524125
   Osvath M, 2009, CURR BIOL, V19, pR190, DOI 10.1016/j.cub.2009.01.010
   Plutchik R, 1994, PSYCHOL BIOL EMOTION, V1st
   Premack D., 1978, BEHAVIORAL BRAIN SCI, V4, P515, DOI [10.1017/S0140525X00076512, DOI 10.1017/S0140525X00076512]
   Reichenbach H., 1947, ELEMENTS SYMBOLIC LO
   Rosati AG, 2007, CURR BIOL, V17, P1663, DOI 10.1016/j.cub.2007.08.033
   Rosenbaum S. R., 2007, SCIENCE, V318, P1257
   Samuels R., DESCARTES C IN PRESS
   Schacter DL, 2008, ANN NY ACAD SCI, V1124, P39, DOI 10.1196/annals.1440.001
   Senghas A, 2004, SCIENCE, V305, P1779, DOI 10.1126/science.1100199
   SEYFARTH RM, 1980, SCIENCE, V210, P801, DOI 10.1126/science.7433999
   Spalletta G, 2010, PSYCHIAT RES-NEUROIM, V182, P77, DOI 10.1016/j.pscychresns.2009.11.001
   Sperber D, 2005, INNATE MIND STRUCTUR, P53, DOI DOI 10.1093/ACPROF:OSO/9780195179675.003.0004
   Sperber D., 1986, RELEVANCE COMMUNICAT
   Suddendorf T, 2007, BEHAV BRAIN SCI, V30, P299, DOI 10.1017/S0140525X07001975
   Suddendorf T, 2009, ANIM COGN, V12, P751, DOI 10.1007/s10071-009-0253-9
   Suddendorf T, 2009, PHILOS T R SOC B, V364, P1317, DOI 10.1098/rstb.2008.0301
   Tooby J, 2008, HDB EMOTIONS, P114
   Tooby John, 1992, ADAPTED MIND EVOLUTI, P19
   Toulopoulouand Timothea, 2004, Expert Rev Neurother, V4, P43, DOI 10.1586/14737175.4.1.43
   Tulving E., 1972, ORG MEMORY, P381
   Tulving Endel, 1983, ELEMENTS EPISODIC ME
   Wilson D., 2004, HDB PRAGMATICS, P607
   Wilson SM, 2008, CEREB CORTEX, V18, P230, DOI 10.1093/cercor/bhm049
NR 84
TC 2
Z9 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0951-5089
EI 1465-394X
J9 PHILOS PSYCHOL
JI Philos. Psychol.
PD FEB 1
PY 2013
VL 26
IS 1
BP 24
EP 46
DI 10.1080/09515089.2011.625119
PG 23
WC Ethics; Psychology, Multidisciplinary
SC Social Sciences - Other Topics; Psychology
GA 057AI
UT WOS:000312533500002
ER

PT J
AU Christensen-Sandfort, RJ
   Whinnery, SB
AF Christensen-Sandfort, Robyn J.
   Whinnery, Stacie B.
TI Impact of Milieu Teaching on Communication Skills of Young Children with
   Autism Spectrum Disorder
SO TOPICS IN EARLY CHILDHOOD SPECIAL EDUCATION
LA English
DT Article
DE Autism Spectrum Disorder; milieu teaching; naturalistic strategies;
   early
ID LANGUAGE INTERVENTION; BEHAVIORAL TREATMENT; TRAINING PARENTS;
   INCLUSION; FAMILIES; HOME
AB This 5-month study examined the impact of a behaviorally based naturalistic teaching strategy, milieu teaching, on the communication skills of preschool-aged children with Autism Spectrum Disorder (ASD) in an early childhood special education (ECSE) classroom. A multiple baseline across participants design was used. Communication targets were selected based on each child's Individualized Education Plan. Milieu teaching strategies were implemented in two activities per day per target. Generalization and maintenance effects were also determined. Results indicated that milieu strategies are an effective means of providing communication skills instruction for young children with ASD in an ECSE classroom.
C1 [Christensen-Sandfort, Robyn J.; Whinnery, Stacie B.] Univ W Florida, Pensacola, FL 32583 USA.
RP Christensen-Sandfort, RJ (reprint author), Univ W Florida, 11000 Univ Pkwy, Pensacola, FL 32583 USA.
EM rchristensen@uwf.edu
CR Alberto P. A., 2006, APPL BEHAV ANAL TEAC, P167
   ALPERT CL, 1992, J EARLY INTERVENTION, V16, P31
   Bimbrauer J. S., 1993, BEHAV CHANGE, V10, P63
   Bricker D, 2000, TOP EARLY CHILD SPEC, V20, P14, DOI 10.1177/027112140002000103
   Bruder MB, 2010, EXCEPT CHILDREN, V76, P339
   Charlop-Christy M. H., 2000, J POSIT BEHAV INTERV, V2, P98, DOI DOI 10.1177/109830070000200203
   Cowan RJ, 2007, PSYCHOL SCHOOLS, V44, P701, DOI 10.1002/pits.20259
   Dawson G., 1996, EFFECTIVENESS EARLY, P307
   DUNLAP G, 1980, J APPL BEHAV ANAL, V13, P619, DOI 10.1901/jaba.1980.13-619
   Gazdag G, 1990, J EARLY INTERVENTION, V14, P62
   Goldstein H, 2002, J AUTISM DEV DISORD, V32, P373, DOI 10.1023/A:1020589821992
   Gresham FM, 1997, BEHAV DISORDERS, V22, P185
   Hancock TB, 2002, TOP EARLY CHILD SPEC, V22, P39, DOI 10.1177/027112140202200104
   Hancock TB, 1996, TOP EARLY CHILD SPEC, V16, P168
   Handelman J. S., 2001, PRESCHOOL ED PROGRAM
   HEMMETER ML, 1994, J EARLY INTERVENTION, V18, P269
   Kaczmarek LA, 1996, TOP EARLY CHILD SPEC, V16, P139
   Kaiser A. P., 2006, INSTRUCTION STUDENTS, P447
   Kaiser A. P., 1995, J CHILDHOOD COMMUNIC, V16, P39
   Kaiser A. P., 2000, EARLY EDUC DEV, V11, P423, DOI 10.1207/s15566935eed1104_4
   Kasari C, 1999, J AUTISM DEV DISORD, V29, P297, DOI 10.1023/A:1022159302571
   Kashinath S, 2006, J SPEECH LANG HEAR R, V49, P466, DOI 10.1044/1092-4388(2006/036)
   Kazdin A. E., 1982, SINGLE CASE RES DESI
   LASKI KE, 1988, J APPL BEHAV ANAL, V21, P391, DOI 10.1901/jaba.1988.21-391
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   National Autism Center, 2009, EV BAS PRACT AUT SCH
   National Research Council, 2001, ED CHILD AUT
   Odom SL, 2000, TOP EARLY CHILD SPEC, V20, P20, DOI 10.1177/027112140002000104
   Odom SL, 2003, J SPEC EDUC, V37, P164, DOI 10.1177/00224669030370030601
   Olive ML, 2007, J AUTISM DEV DISORD, V37, P1505, DOI 10.1007/s10803-006-0243-6
   Peterson P, 2005, J EARLY INTERVENTION, V27, P94, DOI 10.1177/105381510502700205
   Rodi MS, 2000, J ASSOC PERS SEVERE, V25, P175, DOI 10.2511/rpsd.25.3.175
   Sandall S. R., 2000, DEC RECOMMENDED PRAC
   Schopler E., 1993, CHILDHOOD AUTISM RAT
   Sheinkopf SJ, 1998, J AUTISM DEV DISORD, V28, P15, DOI 10.1023/A:1026054701472
   Simpson R. L., 2005, AUTISM SPECTRUM DISO
   Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
   Steege MW, 2007, PSYCHOL SCHOOLS, V44, P91, DOI 10.1002/pits.20208
   Strain P. S., 2001, FOCUS AUTISM OTHER D, V16, P120, DOI DOI 10.1177/108835760101600208
   Strain PS, 2001, BEHAV DISORDERS, V27, P30
   WARREN SF, 1989, J SPEECH HEAR DISORD, V54, P448
   WARREN SF, 1994, J SPEECH HEAR RES, V37, P924
   WARREN SF, 1992, J EARLY INTERVENTION, V16, P235
   Wolery M, 2002, TOP EARLY CHILD SPEC, V22, P14, DOI 10.1177/027112140202200102
NR 44
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0271-1214
J9 TOP EARLY CHILD SPEC
JI Top. Early Child. Spec. Educ.
PD FEB
PY 2013
VL 32
IS 4
BP 211
EP 222
DI 10.1177/0271121411404930
PG 12
WC Education, Special
SC Education & Educational Research
GA 052PR
UT WOS:000312210900002
ER

PT J
AU Vismara, LA
   Young, GS
   Rogers, SJ
AF Vismara, Laurie A.
   Young, Gregory S.
   Rogers, Sally J.
TI Community Dissemination of the Early Start Denver Model: Implications
   for Science and Practice
SO TOPICS IN EARLY CHILDHOOD SPECIAL EDUCATION
LA English
DT Article
DE Early Start Denver Model; implementation research; early intervention;
   Autism Spectrum Disorder; fidelity training
ID YOUNG-CHILDREN; IMPLEMENTATION; AUTISM; DISORDERS; PROVIDERS; FIDELITY
AB The growing number of Autism Spectrum Disorder cases exceeds the services available for these children. This increase challenges both researchers and service providers to develop systematic, effective dissemination strategies for transporting university research models to community early intervention (EI) programs. The current study developed an abbreviated training workshop to teach the Early Start Denver Model (ESDM) to 24 community EI practitioners and examined their fidelity of implementation posttraining and 4 months later. Practitioners successfully implemented and self-assessed their delivery of the ESDM teaching strategies compared with fidelity ratings by expert trainers by the end of the workshop. Those who submitted follow-up materials met fidelity in their direct delivery, whereas their self-assessment of skill delivery appeared lower compared with trainers' fidelity ratings. Findings are discussed about the immediate gains and challenges of community-based dissemination of the ESDM, and the priority for continued research in implementation science to support and sustain intervention delivery.
C1 [Vismara, Laurie A.; Young, Gregory S.; Rogers, Sally J.] UC Davis MIND Inst, Sacramento, CA 95817 USA.
RP Vismara, LA (reprint author), UC Davis MIND Inst, 2825 50th St, Sacramento, CA 95817 USA.
EM laurie.vismara@ucdmc.ucdavis.edu
CR Aarons GA, 2007, ADM POLICY MENT HLTH, V34, P411, DOI 10.1007/s10488-007-0121-3
   Aarons GA, 2009, BEHAV RES THER, V47, P954, DOI 10.1016/j.brat.2009.07.006
   Aarons GA, 2009, AM J PUBLIC HEALTH, V99, P2087, DOI 10.2105/AJPH.2009.161711
   Aarons Gregory A, 2004, Ment Health Serv Res, V6, P61, DOI 10.1023/B:MHSR.0000024351.12294.65
   Aarons GA, 2009, J CONSULT CLIN PSYCH, V77, P270, DOI 10.1037/a0013223
   Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
   Cook T. D., 1979, QUASIEXPERIMENTATION
   Dawson G., 2010, PEDIATRICS, V125, P1
   Fazzio D, 2009, RES AUTISM SPECT DIS, V3, P57, DOI 10.1016/j.rasd.2008.04.002
   Fixsen DL, 2005, IMPLEMENTATION RES S
   Fixsen DL, 2009, RES SOCIAL WORK PRAC, V19, P531, DOI 10.1177/1049731509335549
   Granpeesheh D, 2010, RES AUTISM SPECT DIS, V4, P11, DOI 10.1016/j.rasd.2009.07.004
   Hanft B., 2004, COACHING FAMILIES CO
   Hayward DW, 2009, RES AUTISM SPECT DIS, V3, P571, DOI 10.1016/j.rasd.2008.12.002
   Klein KJ, 1996, ACAD MANAGE REV, V21, P1055, DOI 10.2307/259164
   Koegel LK, 1999, J ASSOC PERS SEVERE, V24, P186, DOI 10.2511/rpsd.24.3.186
   Koegel LK, 1999, J ASSOC PERS SEVERE, V24, P174, DOI 10.2511/rpsd.24.3.174
   KOEGEL RL, 1987, J AUTISM DEV DISORD, V17, P187, DOI 10.1007/BF01495055
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Massatti R. R., 2008, INT J CHILD HLTH HUM, V2, P47
   Rogers S., 1988, J DIVISION EARLY CHI, V10, P135
   Rogers S. J., 1987, J DIVISION EARLY CHI, V11, P180
   ROGERS SJ, 1991, TOP EARLY CHILD SPEC, V11, P29
   ROGERS SJ, 1989, J AM ACAD CHILD PSY, V28, P207, DOI 10.1097/00004583-198903000-00010
   Rogers SJ, 2010, EARLY START DENVER M
   Rutter A., 2003, AUTISM DIAGNOSTIC IN
   Schoenwald SK, 2004, J CLIN CHILD ADOLESC, V33, P94, DOI 10.1207/S15374424JCCP3301_10
   Schreibman L., 1988, AUTISM
   Sholomskas DE, 2005, J CONSULT CLIN PSYCH, V73, P106, DOI 10.1037/0022.006X.73.1.106
   Stahmer AC, 2009, PSYCHOL SERV, V6, P223, DOI 10.1037/a0010738
   van Oorsouw WMWJ, 2009, RES DEV DISABIL, V30, P503, DOI 10.1016/j.ridd.2008.07.011
   Vismara LA, 2009, J AUTISM DEV DISORD, V39, P1636, DOI 10.1007/s10803-009-0796-2
   Waller G, 2009, BEHAV RES THER, V47, P119, DOI 10.1016/j.brat.2008.10.018
   Wood AL, 2007, BEHAV MODIF, V31, P847, DOI 10.1177/0145445507302893
NR 34
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0271-1214
J9 TOP EARLY CHILD SPEC
JI Top. Early Child. Spec. Educ.
PD FEB
PY 2013
VL 32
IS 4
BP 223
EP 233
DI 10.1177/0271121411409250
PG 11
WC Education, Special
SC Education & Educational Research
GA 052PR
UT WOS:000312210900003
ER

PT J
AU Hughett, K
   Kohler, FW
   Raschke, D
AF Hughett, Kristy
   Kohler, Frank W.
   Raschke, Donna
TI The Effects of a Buddy Skills Package on Preschool Children's Social
   Interactions and Play
SO TOPICS IN EARLY CHILDHOOD SPECIAL EDUCATION
LA English
DT Article
DE interaction; peer-mediated
ID YOUNG-CHILDREN; BEHAVIOR; AUTISM; INTERVENTION; MAINTENANCE;
   INITIATIONS; CLASSROOM; PEERS
AB The purpose of this study was to examine the impact of a buddy skills package on the social and play interactions between three preschoolers with developmental delays and their peers. Each child participated in sociodramatic play activities with two peers who exhibited age-appropriate social and play skills. Following baseline, the children participated in three sessions of training on the strategies of stay, play, and talk with your friends. The intervention consisting of teacher feedback, praise, and picture cards was then used to support children's social interactions and play. A multiple baseline design indicated that the package was effective for increasing children's cooperative play in the exchange of activity-related comments. In addition, each playgroup continued to demonstrate these positive outcomes during a maintenance condition.
C1 [Kohler, Frank W.] Univ No Iowa, Schindler Educ Ctr 150, Cedar Falls, IA 50614 USA.
RP Kohler, FW (reprint author), Univ No Iowa, Schindler Educ Ctr 150, Cedar Falls, IA 50614 USA.
EM frank.kohler@uni.edu
CR Benedict EA, 2007, TOP EARLY CHILD SPEC, V27, P174, DOI 10.1177/02711214070270030801
   BROWN WH, 1994, RES DEV DISABIL, V15, P99, DOI 10.1016/0891-4222(94)90016-7
   CHANDLER LK, 1992, J APPL BEHAV ANAL, V25, P415, DOI 10.1901/jaba.1992.25-415
   Cooke T. P., 1978, EARLY INTERVENTION I, P147
   English K., 1996, TEACHING EXCEPTIONAL, V28, P62
   Ferrell D. R., 1987, J SPEECH HEAR DISORD, V19, P200
   GOLDSTEIN H, 1992, J APPL BEHAV ANAL, V25, P289, DOI 10.1901/jaba.1992.25-289
   Goldstein H, 1997, J SPEECH LANG HEAR R, V40, P33
   Guralnick M. J., 2001, EARLY CHILDHOOD INCL
   HENDRICKSON JM, 1982, BEHAV MODIF, V6, P323, DOI 10.1177/014544558263002
   Kohler F. W., 1993, TEACHING EXCEPTIONAL, V25, P41
   Kohler FW, 2007, TOP EARLY CHILD SPEC, V27, P155, DOI 10.1177/02711214070270030601
   McConnell SR, 2002, J AUTISM DEV DISORD, V32, P351, DOI 10.1023/A:1020537805154
   Odom S. L., 1988, EARLY INTERVENTION I, P241
   Odom S. L., 2003, FOCUS AUTISM OTHER D, V18, P166, DOI DOI 10.1177/10883576030180030401
   ODOM SL, 1985, J APPL BEHAV ANAL, V18, P3, DOI 10.1901/jaba.1985.18-3
   Odom SL, 2009, TOP EARLY CHILD SPEC, V29, P53, DOI 10.1177/0271121408329171
   PECK CA, 1978, J SPEC EDUC, V12, P195
   Powell D., 2009, PROMOTING SOCIAL BEH
   STOKES TF, 1978, J ABNORM CHILD PSYCH, V6, P203, DOI 10.1007/BF00919125
   Strain P. S., 2001, EARLY CHILDHOOD INCL, P337
   STRAIN PS, 1974, J APPL BEHAV ANAL, V7, P583, DOI 10.1901/jaba.1974.7-583
   STRAIN PS, 1977, J APPL BEHAV ANAL, V10, P289, DOI 10.1901/jaba.1977.10-289
   Technical Assistance Center on Social and Emotional Intervention, 2011, TECHN ASS CTR SOC EM
   Tsao LL, 2006, TOP EARLY CHILD SPEC, V26, P106, DOI 10.1177/02711214060260020101
   Voress J, 1998, DEV ASSESSMENT YOUNG
   Wang PS, 2009, EDUC TRAIN DEV DISAB, V44, P318
NR 27
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0271-1214
J9 TOP EARLY CHILD SPEC
JI Top. Early Child. Spec. Educ.
PD FEB
PY 2013
VL 32
IS 4
BP 246
EP 254
DI 10.1177/0271121411424927
PG 9
WC Education, Special
SC Education & Educational Research
GA 052PR
UT WOS:000312210900005
ER

PT J
AU Rodriguez-Tornos, FM
   San Aniceto, I
   Cubelos, B
   Nieto, M
AF Rodriguez-Tornos, Fernanda M.
   San Aniceto, Inigo
   Cubelos, Beatriz
   Nieto, Marta
TI Enrichment of Conserved Synaptic Activity-Responsive Element in Neuronal
   Genes Predicts a Coordinated Response of MEF2, CREB and SRF
SO PLOS ONE
LA English
DT Article
ID ACTIVITY-DEPENDENT REGULATION; AUTISM SPECTRUM DISORDERS; EXPRESSION;
   PROTEINS; MEMORY; HOMER; TRANSCRIPTION; HIPPOCAMPAL; REQUIREMENT;
   PLASTICITY
AB A unique synaptic activity-responsive element (SARE) sequence, composed of the consensus binding sites for SRF, MEF2 and CREB, is necessary for control of transcriptional upregulation of the Arc gene in response to synaptic activity. We hypothesize that this sequence is a broad mechanism that regulates gene expression in response to synaptic activation and during plasticity; and that analysis of SARE-containing genes could identify molecular mechanisms involved in brain disorders. To search for conserved SARE sequences in the mammalian genome, we used the SynoR in silico tool, and found the SARE cluster predominantly in the regulatory regions of genes expressed specifically in the nervous system; most were related to neural development and homeostatic maintenance. Two of these SARE sequences were tested in luciferase assays and proved to promote transcription in response to neuronal activation. Supporting the predictive capacity of our candidate list, up-regulation of several SARE containing genes in response to neuronal activity was validated using external data and also experimentally using primary cortical neurons and quantitative real time RT-PCR. The list of SARE-containing genes includes several linked to mental retardation and cognitive disorders, and is significantly enriched in genes that encode mRNA targeted by FMRP (fragile X mental retardation protein). Our study thus supports the idea that SARE sequences are relevant transcriptional regulatory elements that participate in plasticity. In addition, it offers a comprehensive view of how activity-responsive transcription factors coordinate their actions and increase the selectivity of their targets. Our data suggest that analysis of SARE-containing genes will reveal yet-undescribed pathways of synaptic plasticity and additional candidate genes disrupted in mental disease.
C1 [Rodriguez-Tornos, Fernanda M.; Nieto, Marta] CSIC, CNB, Madrid, Spain.
   [San Aniceto, Inigo] Univ Complutense Madrid, Fac Informat, Madrid, Spain.
   [Cubelos, Beatriz] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Madrid, Spain.
RP Nieto, M (reprint author), CSIC, CNB, Darwin 3,Campus Cantoblanco, Madrid, Spain.
EM mnlopez@cnb.csic.es
RI Nieto, Marta/F-1434-2013
FU Ministerio de Ciencia e Innovacion (MICINN) [SAF2008-00211, PIE-
   200820I166]; Spanish Comunidad de Madrid [CCG08-CSIC/SAL-3464]
FX This work was funded by the Ministerio de Ciencia e Innovacion (MICINN)
   grants (SAF2008-00211; PIE- 200820I166), and a grant from the Spanish
   Comunidad de Madrid CCG08-CSIC/SAL-3464. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Azim E, 2009, NAT NEUROSCI, V12, P1238, DOI 10.1038/nn.2387
   Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
   Batista-Brito R, 2009, NEURON, V63, P466, DOI 10.1016/j.neuron.2009.08.005
   Benito E, 2010, TRENDS NEUROSCI, V33, P230, DOI 10.1016/j.tins.2010.02.001
   Benito E, 2011, J NEUROSCI, V31, P18237, DOI 10.1523/JNEUROSCI.4554-11.2011
   Bottai D, 2002, J NEUROSCI, V22, P167
   Cubelos B, 2010, NEURON, V66, P523, DOI 10.1016/j.neuron.2010.04.038
   Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
   Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017
   Flavell SW, 2006, SCIENCE, V311, P1008, DOI 10.1126/science.1122511
   Herrera E, 2003, CELL, V114, P545, DOI 10.1016/S0092-8674(03)00684-6
   Hoeffer CA, 2010, TRENDS NEUROSCI, V33, P67, DOI 10.1016/j.tins.2009.11.003
   Huang ZJ, 2006, NAT NEUROSCI, V9, P163, DOI 10.1038/nn1638
   Inoue N, 2009, MOL BRAIN, V2, DOI 10.1186/1756-6606-2-7
   Kandel E., 2001, LOGIC CIRCUITS CARBO, V295, P1030
   Kawashima T, 2009, P NATL ACAD SCI USA, V106, P316, DOI 10.1073/pnas.0806518106
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Kim TK, 2010, NATURE, V465, P182, DOI 10.1038/nature09033
   Laumonnier F, 2006, AM J PSYCHIAT, V163, P1622, DOI 10.1176/appi.ajp.163.9.1622
   Lin YX, 2008, NATURE, V455, P1198, DOI 10.1038/nature07319
   Liu XL, 2012, GENOME RES, V22, P611, DOI 10.1101/gr.127324.111
   Luscher C, 2010, NEURON, V65, P445, DOI 10.1016/j.neuron.2010.01.016
   MacDermot KD, 2005, AM J HUM GENET, V76, P1074, DOI 10.1086/430841
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Ovcharenko I, 2005, NUCLEIC ACIDS RES, V33, pW403, DOI 10.1093/nar/gki466
   Pasterkamp RJ, 2009, CURR OPIN NEUROBIOL, V19, P263, DOI 10.1016/j.conb.2009.06.001
   Ramanan N, 2005, NAT NEUROSCI, V8, P759, DOI 10.1038/nn1462
   Sala C, 2005, J NEUROSCI, V25, P4587, DOI 10.1523/JNEUROSCI.4822-04.2005
   Schaaf CP, 2011, HUM MOL GENET, V20, P3366, DOI 10.1093/hmg/ddr243
   Tu JC, 1999, NEURON, V23, P583, DOI 10.1016/S0896-6273(00)80810-7
   Upadhya SC, 2011, NEUROCHEM INT, V59, P787, DOI 10.1016/j.neuint.2011.08.009
   Vazdarjanova A, 2002, J NEUROSCI, V22, P10067
   Walsh CA, 2008, CELL, V135, P396, DOI 10.1016/j.cell.2008.10.015
   Worley PF, 2007, CELL CALCIUM, V42, P363, DOI 10.1016/j.ceca.2007.05.007
   Yuan JP, 2003, CELL, V114, P777, DOI 10.1016/S0092-8674(03)00716-5
   Zhou YP, 2008, TRENDS BIOCHEM SCI, V33, P161, DOI 10.1016/j.tibs.2008.01.006
NR 36
TC 2
Z9 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 31
PY 2013
VL 8
IS 1
AR e53848
DI 10.1371/journal.pone.0053848
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 085JH
UT WOS:000314610600019
PM 23382855
ER

PT J
AU Hutsler, JJ
   Avino, TA
AF Hutsler, Jeffrey J.
   Avino, Thomas A.
TI Sigmoid fits to locate and characterize cortical boundaries in human
   cerebral cortex
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE Cerebral cortex; Microscopy technique; Neuroanatomy; Subplate
ID AUTISM SPECTRUM DISORDERS; NEUROPATHOLOGY; ARCHITECTURE; STEREOLOGY;
   THICKNESS; AREAS
AB Quantitative evaluation of neuropathology within the cortex often requires a significant investigator time commitment. Here we elaborate on a method of quantifying the distinctiveness of the gray-white matter boundary using function fitting methods (Avino and Hutsler, 2010) and demonstrate that it can also be adapted to reliably identify the location of the gray matter/white matter (GM-WM) boundary in microscopic images, even when that boundary is indistinct. Multiple images of the gray-white matter boundary were acquired from sixteen subjects. Density profiles across the cortical layers were acquired and sigmoid functions were iteratively fit to the density profiles until a best fit was found. The slope of the resulting sigmoid was used to describe both the position and distinctiveness of the GM-WM boundary. Subsequently, two raters laid cortical boundaries on the same set of images and agreement between the raters, as well as agreement between each rater and the transverse-based boundaries, was assessed. Computer-generated boundaries showed reliably higher agreement with each individual rater, relative to the agreement between individual raters. Error between the raters and the transverse-based boundaries was associated with those images where the boundary was less distinct as assessed by the sigmoid slopes. These findings suggest that transverse-based boundaries are superior to user-generated boundaries. Furthermore, these findings suggest that rater-based boundary definitions in both neurotypical and pathological cases may become unreliable as the number of cell profiles found in the subplate region increases, as is the case in both autism and schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Hutsler, Jeffrey J.; Avino, Thomas A.] Univ Nevada, Dept Psychol, Program Neurosci, Reno, NV 89557 USA.
RP Hutsler, JJ (reprint author), Univ Nevada, Dept Psychol, MS 296, Reno, NV 89557 USA.
EM jhutsler@unr.edu
CR Annese J, 2004, NEUROIMAGE, V21, P15, DOI 10.1016/j.neuroimage.2003.08.024
   Avino TA, 2010, BRAIN RES, V1360, P138, DOI 10.1016/j.brainres.2010.08.091
   Bailey P, 1925, ISOCORTEX MAN
   Bauman ML, 2003, NOVART FDN SYMP, V251, P112
   Buxhoeveden DP, 2002, BRAIN BEHAV EVOLUT, V60, P125, DOI 10.1159/000065935
   Casanova MF, 2002, NEUROLOGY, V58, P428
   Casanova MF, 2006, CLIN NEUROSCI RES, V6, P127, DOI 10.1016/j.cnr.2006.06.003
   Friedenberg J, 2002, PERCEPT PSYCHOPHYS, V64, P531, DOI 10.3758/BF03194724
   Hardan AY, 2005, BIOL PSYCHIAT, V57, p10S
   HUDSPETH AJ, 1976, P NATL ACAD SCI USA, V73, P2928, DOI 10.1073/pnas.73.8.2928
   Hutsler JJ, 2010, BRAIN RES, V1309, P83, DOI 10.1016/j.brainres.2009.09.120
   Hutsler JJ, 2007, BIOL PSYCHIAT, V61, P449, DOI 10.1016/j.biopsych.2006.01.015
   Jones EG, 2010, CEREB CORTEX, V20, P2261, DOI 10.1093/cercor/bhq127
   Kemper TL, 1998, J NEUROPATH EXP NEUR, V57, P645, DOI 10.1097/00005072-199807000-00001
   Kristiansen SLB, 2012, APMIS, V120, P327, DOI 10.1111/j.1600-0463.2012.02889.x
   Lemmens MAM, 2010, J CHEM NEUROANAT, V40, P199, DOI 10.1016/j.jchemneu.2010.06.005
   Mackey S, 2009, NEUROSCIENCE, V159, P1089, DOI 10.1016/j.neuroscience.2009.01.036
   Marin-Padilla M, 2002, ACTA NEUROPATHOL, V103, P321, DOI 10.1007/s00401-001-0470-z
   Schleicher A, 2000, J CHEM NEUROANAT, V20, P31, DOI 10.1016/S0891-0618(00)00076-4
   Schmitz C, 2005, NEUROSCIENCE, V130, P813, DOI 10.1016/j.neuroscience.2004.08.050
   von Economo C., 1925, CYTOARCHITEKTONIK HI
NR 21
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD JAN 30
PY 2013
VL 212
IS 2
BP 242
EP 246
DI 10.1016/j.jneumeth.2012.10.007
PG 5
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 104EJ
UT WOS:000315974200010
PM 23137653
ER

PT J
AU Laszlo, A
   Novak, Z
   Szollosi-Varga, I
   Hai, DQ
   Vetro, A
   Kovacs, A
AF Laszlo, Aranka
   Novak, Zoltan
   Szollosi-Varga, Ilona
   Hai, Du Quai
   Vetro, Agnes
   Kovacs, Attila
TI BLOOD LIPID PEROXIDATION, ANTIOXIDANT ENZYME ACTIVITIES AND
   HEMORHEOLOGICAL CHANGES IN AUTISTIC CHILDREN
SO IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE
LA English
DT Article
DE lipid peroxidation (LP); plasma; red blood cell haemolysate; antioxidant
   enzymes; RBC deformability
ID OXIDATIVE STRESS; SPECTRUM DISORDERS; SEROTONIN
AB Objectives - Early infantile autism is a severe form of childhood psychiatric disease with characteristic symptoms. Hyperserotoninaemia in 43.5%, lactic acidosis 43% and hyperpyruvataemia in 30% were biochemically demonstrated in autistic children.
   Our earlier results led to the postulation that a disequilibrium in the blood redox is involved in infantile autism; the oxidative loading and the antioxidant defending enzyme system were investigated together with the hemorheological parameters in infantile autism.
   Methods - Malonyl-dialdehyde (MDA) endproduct of lipid peroxidation and activities of the antioxidant enzymes: superoxide dismutase (SOD), catalase (C-ase), glutathione peroxidase (GP-ase) and reduced glutathione (GSH) were biochemically determined from plasma and red blood cells. Patients - The antioxidant specificities were investigated in plasma and red blood cell haemolysate from 25 infantile autistic children.
   Results - Significantly increased superoxide dismutase (SOD) (2.89 vs. 1.32 U/mg protein, p<0.01) and decreased glutathione peroxidase (0.620 vs. 0.910 U/mg protein, p<0.01) levels as well as catalase (0.463 vs. 4.948 BU/mg protein, p<0.001) activities were detected; while the plasma and erythrocyte lipid peroxidation and the reduced glutathione (GSH) levels did not change. The results of the investigated prooxidant and the antioxidant status provide evidence that there exists an oxidative stress in children with infantile autism.
   While investigating the hemorheological parameters of 25 infantile autistic patients, some characteristic pathological parameters were detected: the initial filtration rate (Fi) (0.72 vs. 0.75 p<0,01) and the clogging rate (CR) (1.926 vs. 2.912, p<0.01) values of red blood cells (RBC) decreased while the mean transit time (Tc) (8.93 vs. 7.39, p<0.001) increased suggesting reduced RBC deformability.
C1 [Laszlo, Aranka; Novak, Zoltan] Univ Szeged, Dept Pediat, H-6720 Szeged, Hungary.
   [Szollosi-Varga, Ilona; Hai, Du Quai] Univ Szeged, Dept Biochem & Mol Biol, H-6720 Szeged, Hungary.
   [Kovacs, Attila] Hosp Hungarian State Railways, Dept Rheumatol, Szeged, Hungary.
   [Vetro, Agnes] Univ Szeged, Dept Childrens Psychiat, H-6720 Szeged, Hungary.
RP Laszlo, A (reprint author), Univ Szeged, Dept Pediat, A Szent Gyorgyi Med Ctr, Koranyi Fasor 14-15, H-6720 Szeged, Hungary.
EM laszloar@pedia.szote.u-szeged.hu
CR Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Kanner L, 1943, NERV CHILD, V2, P217
   Kern JK, 2006, J TOXICOL ENV HEAL B, V9, P485, DOI 10.1080/10937400600882079
   LASZLO A, 1994, CLIN CHIM ACTA, V229, P205, DOI 10.1016/0009-8981(94)90243-7
   LAU CS, 1995, ARTHRITIS RHEUM, V38, P248, DOI 10.1002/art.1780380214
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   MacFabe DF, 2007, BEHAV BRAIN RES, V176, P149, DOI 10.1016/j.bbr.2006.07.025
   MATKOVICS B, 1977, COMP BIOCHEM PHYS B, V56, P31, DOI 10.1016/0305-0491(77)90218-8
   Ming X, 2005, PROSTAG LEUKOTR ESS, V73, P379, DOI 10.1016/j.plefa.2005.06.002
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   NOVAK Z, 1989, Biorheology, V26, P575
   NOVAK Z, 1989, CLIN CHIM ACTA, V182, P241, DOI 10.1016/0009-8981(89)90101-0
   PLACER ZA, 1966, ANAL BIOCHEM, V16, P359, DOI 10.1016/0003-2697(66)90167-9
   Politi P, 2008, ARCH MED RES, V39, P682, DOI 10.1016/j.arcmed.2008.06.005
   Pons R, 2004, J PEDIATR-US, V144, P81, DOI 10.1016/j.jpeds.2003.10.023
   Scheibman L, 1988, J CHILD NEUROL S, V3, pS57
   Sedlak I., 1968, ANAL BIOCHEM, V25, P192
   SZABO G, 1983, ACTA PHYSIOL HUNG, V61, P51
   Weiss LA, 2003, MOL PSYCHIATR, V8, P186, DOI 10.1038/sj.mp.4001241
   Yao YM, 2006, ARCH NEUROL-CHICAGO, V63, P1161, DOI 10.1001/archneur.63.8.1161
   Yu WF, 2003, NEUROSCI LETT, V338, P13, DOI 10.1016/S0304-3940(02)01361-7
   Zoroglu SS, 2004, EUR ARCH PSY CLIN N, V254, P143, DOI 10.1007/s00406-004-0456-7
NR 22
TC 2
Z9 3
PU LITERATURA MEDICA
PI BUDAPEST
PA MARGIT KRT 31-33, BUDAPEST, 1024, HUNGARY
SN 0019-1442
J9 IDEGGYOGY SZEMLE
JI Ideggyogy. Szle.
PD JAN 30
PY 2013
VL 66
IS 1-2
BP 23
EP 28
PG 6
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 086FL
UT WOS:000314669400005
PM 23607226
ER

PT J
AU Kondapalli, KC
   Hack, A
   Schushan, M
   Ben-Tal, N
   Rao, R
AF Kondapalli, Kalyan C.
   Hack, Anniesha
   Schushan, Maya
   Ben-Tal, Nir
   Rao, Rajini
TI Functional Evaluation of Autism Associated Mutations in Slc9A9 (NHE9)
SO BIOPHYSICAL JOURNAL
LA English
DT Meeting Abstract
CT 57th Annual Meeting of the Biophysical-Society
CY FEB 02-06, 2013
CL Philadelphia, PA
SP Biophys Soc
C1 [Kondapalli, Kalyan C.; Hack, Anniesha; Rao, Rajini] Johns Hopkins Univ, Baltimore, MD USA.
   [Schushan, Maya; Ben-Tal, Nir] Tel Aviv Univ, IL-69978 Tel Aviv, Israel.
NR 0
TC 0
Z9 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0006-3495
J9 BIOPHYS J
JI Biophys. J.
PD JAN 29
PY 2013
VL 104
IS 2
SU 1
BP 22A
EP 22A
PG 1
WC Biophysics
SC Biophysics
GA 105MI
UT WOS:000316074300118
ER

PT J
AU Limpitikul, W
   Johny, MB
   Yue, DT
AF Limpitikul, Worawan
   Johny, Manu B.
   Yue, David T.
TI Autism-Associated Point Mutation in Ca(V)1.3 Calcium Channels alters
   their Regulation by Ca2+
SO BIOPHYSICAL JOURNAL
LA English
DT Meeting Abstract
CT 57th Annual Meeting of the Biophysical-Society
CY FEB 02-06, 2013
CL Philadelphia, PA
SP Biophys Soc
C1 [Limpitikul, Worawan; Johny, Manu B.; Yue, David T.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
NR 0
TC 0
Z9 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0006-3495
J9 BIOPHYS J
JI Biophys. J.
PD JAN 29
PY 2013
VL 104
IS 2
SU 1
BP 459A
EP 459A
PG 1
WC Biophysics
SC Biophysics
GA 105MI
UT WOS:000316074304329
ER

PT J
AU Lin, HC
   Gean, PW
   Wang, CC
   Chan, YH
   Chen, PS
AF Lin, Hui-Ching
   Gean, Po-Wu
   Wang, Chao-Chuan
   Chan, Yun-Han
   Chen, Po See
TI The Amygdala Excitatory/Inhibitory Balance in a Valproate-Induced Rat
   Autism Model
SO PLOS ONE
LA English
DT Article
ID PRENATAL EXPOSURE; ANIMAL-MODEL; LATERAL AMYGDALA; SOCIAL ANXIETY;
   SYNAPTIC PLASTICITY; SPECTRUM DISORDERS; NMDA RECEPTORS; FEAR MEMORY;
   IN-VIVO; BRAIN
AB The amygdala is an important structure contributing to socio-emotional behavior. However, the role of the amygdala in autism remains inconclusive. In this study, we used the 28-35 days valproate (VPA)-induced rat model of autism to observe the autistic phenotypes and evaluate their synaptic characteristics in the lateral nucleus (LA) of the amygdala. The VPA-treated offspring demonstrated less social interaction, increased anxiety, enhanced fear learning and impaired fear memory extinction. Slice preparation and electrophysiological recordings of the amygdala showed significantly enhanced long-term potentiation (LTP) while stimulating the thalamic-amygdala pathway of the LA. In addition, the pair pulse facilitation (PPF) at 30- and 60-ms intervals decreased significantly. Whole-cell recordings of the LA pyramidal neurons showed an increased miniature excitatory postsynaptic current (EPSC) frequency and amplitude. The relative contributions of the AMPA receptor and NMDA receptor to the EPSCs did not differ significantly between groups. These results suggested that the enhancement of the presynaptic efficiency of excitatory synaptic transmission might be associated with hyperexcitibility and enhanced LTP in LA pyramidal neurons. Disruption of the synaptic excitatory/inhibitory (E/I) balance in the LA of VPA-treated rats might play certain roles in the development of behaviors in the rat that may be relevant to autism. Further experiments to demonstrate the direct link are warranted.
C1 [Lin, Hui-Ching] Natl Yang Ming Univ, Sch Med, Dept & Inst Physiol, Taipei 112, Taiwan.
   [Lin, Hui-Ching] Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, Taiwan.
   [Gean, Po-Wu; Chan, Yun-Han] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan.
   [Wang, Chao-Chuan] Kaohsiung Med Univ, Coll Med, Dept Anat, Kaohsiung, Taiwan.
   [Chan, Yun-Han] Ctr Drug Evaluat, Taipei, Taiwan.
   [Chen, Po See] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Psychiat, Tainan 70101, Taiwan.
   [Chen, Po See] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 70101, Taiwan.
RP Chen, PS (reprint author), Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Psychiat, Tainan 70101, Taiwan.
EM chenps@mail.ncku.edu.tw
FU National Science Council, Taiwan [NSC 99-2628-B-006-013, NSC
   96-2314-B-006-056, NSC 100-2320-B-010-033-MY2]; Aim for the Top
   University Plan from the National Cheng Kung University; Aim for the Top
   University Plan from the National Yang-Ming University; National Cheng
   Kung Hospital [NCKUH-10005008]
FX Funding provided by the National Science Council, Taiwan
   (http://web1.nsc.gov.tw/mp.aspx?mp=7; NSC 99-2628-B-006-013, NSC
   96-2314-B-006-056, NSC 100-2320-B-010-033-MY2); Aim for the Top
   University Plan from the National Cheng Kung University
   (http://top-en.ncku.edu.tw/bin/home.php); Aim for the Top University
   Plan from the National Yang-Ming University
   (http://www.ym.edu.tw/top/eng/index.html); and National Cheng Kung
   Hospital
   (http://www.hosp.ncku.edu.tw/nckm/english/HomeStyle.aspx?Type=11&Content
   Page=0; NCKUH-10005008). The funders had no role in the study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Adolphs R, 2006, PROG BRAIN RES, V156, P363, DOI 10.1016/S0079-6123(06)56020-0
   Adolphs R, 2009, ANNU REV PSYCHOL, V60, P693, DOI 10.1146/annurev.psych.60.110707.163514
   Amaral DG, 2002, BIOL PSYCHIAT, V51, P11, DOI 10.1016/S0006-3223(01)01307-5
   Aylward EH, 1999, NEUROLOGY, V53, P2145
   Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   Barad M, 2006, BIOL PSYCHIAT, V60, P322, DOI 10.1016/j.biopsych.2006.05.029
   Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
   Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
   Barrow SL, 2009, NEURAL DEV, V4, DOI 10.1186/1749-8104-4-17
   Becker B, 2012, BIOL PSYCHIAT, V72, P70, DOI 10.1016/j.biopsych.2011.11.024
   Bellone C, 2006, NAT NEUROSCI, V9, P636, DOI 10.1038/nn1682
   Bickart KC, 2011, NAT NEUROSCI, V14, P163, DOI 10.1038/nn.2724
   Blair RJR, 2006, J CHILD PSYCHOL PSYC, V47, P262, DOI 10.1111/j.1469-7610.2006.01596.x
   Blundell J, 2010, J NEUROSCI, V30, P2115, DOI 10.1523/JNEUROSCI.4517-09.2010
   Chiao JY, 2008, J COGNITIVE NEUROSCI, V20, P2167, DOI 10.1162/jocn.2008.20151
   Clem RL, 2006, NEURON, V49, P663, DOI 10.1016/j.neuron.2006.01.019
   Cottraux J, 2005, CURR OPIN PSYCHIATR, V18, P51
   Craig AM, 2007, CURR OPIN NEUROBIOL, V17, P43, DOI 10.1016/j.conb.2007.01.011
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Damsa C, 2005, CURR OPIN PSYCHIATR, V18, P55
   Du J, 2008, J NEUROSCI, V28, P68, DOI 10.1523/JNEUROSCI.3080-07.2008
   Emery NJ, 2001, BEHAV NEUROSCI, V115, P515, DOI 10.1037//0735-7044.115.3.515
   Etherton MR, 2011, EMBO J, V30, P2908, DOI 10.1038/emboj.2011.182
   Evans DW, 2005, CHILD PSYCHIAT HUM D, V36, P3, DOI 10.1007/s10578-004-3619-x
   Flagstad P, 2004, NEUROPSYCHOPHARMACOL, V29, P2052, DOI 10.1038/sj.npp.1300516
   Gadziola MA, 2012, J NEUROPHYSIOL, V107, P1047, DOI 10.1152/jn.00422.2011
   Genton P, 2006, DRUG SAFETY, V29, P1, DOI 10.2165/00002018-200629010-00001
   Hadjikhani N, 2007, HUM BRAIN MAPP, V28, P441, DOI 10.1002/hbm.20283
   Hampton AN, 2007, NEURON, V55, P545, DOI 10.1016/j.neuron.2007.07.022
   HERITCH AJ, 1990, J PSYCHIAT RES, V24, P251, DOI 10.1016/0022-3956(90)90014-H
   HESS G, 1987, NEUROSCI LETT, V77, P187, DOI 10.1016/0304-3940(87)90584-2
   Iwasaki-Sekino A, 2009, PSYCHONEUROENDOCRINO, V34, P226, DOI 10.1016/j.psyneuen.2008.09.003
   Jung SY, 2010, P NATL ACAD SCI USA, V107, P4710, DOI 10.1073/pnas.1001084107
   Kataoka S, 2011, INT J NEURO IN PRESS
   Keightley ML, 2007, SOC COGN AFFECT NEUR, V2, P292, DOI 10.1093/scan/nsm024
   Kennedy DP, 2009, NAT NEUROSCI, V12, P1226, DOI 10.1038/nn.2381
   Kleinhans NM, 2010, NEUROPSYCHOLOGIA, V48, P3665, DOI 10.1016/j.neuropsychologia.2010.07.022
   Kuzmanovic B., 2011, NEUROIMAGE, V60, P179
   Lederbogen F, 2011, NATURE, V474, P498, DOI 10.1038/nature10190
   LeDoux J, 2003, CELL MOL NEUROBIOL, V23, P727, DOI 10.1023/A:1025048802629
   LEDOUX JE, 1995, ANNU REV PSYCHOL, V46, P209, DOI 10.1146/annurev.psych.46.1.209
   Lin HC, 2011, J NEUROSCI, V31, P8851, DOI 10.1523/JNEUROSCI.0979-11.2011
   Lin HC, 2010, INT J NEUROPSYCHOPH, V13, P335, DOI 10.1017/S1461145709990678
   Marin O, 2012, NAT REV NEUROSCI, V13, P107, DOI 10.1038/nrn3155
   Markowitsch HJ, 2011, NEUROPSYCHOLOGIA, V49, P718, DOI 10.1016/j.neuropsychologia.2010.10.007
   Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
   Mcrae K, 2012, SOC COGN AFFECT NEUR, V7, P11, DOI 10.1093/scan/nsr093
   Miyazaki K, 2005, INT J DEV NEUROSCI, V23, P287, DOI 10.1016/j.ijdevneu.2004.05.004
   Muscatell KA, 2012, NEUROIMAGE IN PRESS
   Nacewicz BM, 2006, ARCH GEN PSYCHIAT, V63, P1417, DOI 10.1001/archpsyc.63.12.1417
   Nelson ED, 2011, J NEUROPHYSIOL, V106, P193, DOI 10.1152/jn.00751.2010
   Pejic T, 2011, SOCIAL COGN IN PRESS
   Rasalam AD, 2005, DEV MED CHILD NEUROL, V47, P551, DOI 10.1017/S0012162205001076
   Rinaldi T, 2007, P NATL ACAD SCI USA, V104, P13501, DOI 10.1073/pnas.0704391104
   Rinaldi T, 2008, CEREB CORTEX, V18, P763, DOI 10.1093/cercor/bhm117
   Rojas DC, 2004, AM J PSYCHIAT, V161, P2038, DOI 10.1176/appi.ajp.161.11.2038
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Saygin ZM, 2011, NEUROIMAGE, V56, P1353, DOI 10.1016/j.neuroimage.2011.03.006
   Scheiffele P, 2000, CELL, V101, P657, DOI 10.1016/S0092-8674(00)80877-6
   Schneider T, 2008, PSYCHONEUROENDOCRINO, V33, P728, DOI 10.1016/j.psyneuen.2008.02.011
   Schneider T, 2007, PSYCHOPHARMACOLOGY, V193, P547, DOI 10.1007/s00213-007-0795-y
   Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
   Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   Todd RM, 2009, NAT NEUROSCI, V12, P1217, DOI 10.1038/nn1009-1217
   Tsuchiya N, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003892
   Wagner GC, 2006, J AUTISM DEV DISORD, V36, P779, DOI 10.1007/s10803-006-0117-y
   Walcott EC, 2011, J NEUROSCI, V31, P13097, DOI 10.1523/JNEUROSCI.1341-11.2011
   Wang AT, 2004, J AM ACAD CHILD PSY, V43, P481, DOI 10.1097/01.chi.0000111481.76722.66
   WASHBURN MS, 1992, J NEUROSCI, V12, P4066
   Whalley K, 2012, NAT REV NEUROSCI, V13, P3, DOI 10.1038/nrn3152
   Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
   Yu SY, 2008, J NEUROCHEM, V106, P889, DOI 10.1111/j.1471-4159.2008.05461.x
NR 75
TC 12
Z9 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 29
PY 2013
VL 8
IS 1
AR e55248
DI 10.1371/journal.pone.0055248
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 097OK
UT WOS:000315483200059
PM 23383124
ER

PT J
AU van Boxtel, JJA
   Lu, HJ
AF van Boxtel, Jeroen J. A.
   Lu, Hongjing
TI A predictive coding perspective on autism spectrum disorders
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Editorial Material
ID PERCEPTION; ACTIVATION
C1 [van Boxtel, Jeroen J. A.; Lu, Hongjing] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
   [Lu, Hongjing] Univ Calif Los Angeles, Dept Stat, Los Angeles, CA USA.
RP van Boxtel, JJA (reprint author), Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
EM j.j.a.vanboxtel@gmail.com
RI van Boxtel, Jeroen/O-7624-2014
OI van Boxtel, Jeroen/0000-0003-2643-0474
CR Belmonte MK, 2004, MOL PSYCHIATR, V9, P646, DOI 10.1038/sj.mp.4001499
   Brock J, 2012, TRENDS COGN SCI, V16, P573, DOI 10.1016/j.tics.2012.10.005
   Brosnan MJ, 2004, J CHILD PSYCHOL PSYC, V45, P459, DOI 10.1111/j.1469-7610.2004.00237.x
   Feldman H, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00215
   Geurts HM, 2008, NEUROPSYCHOLOGIA, V46, P3030, DOI 10.1016/j.neuropsychologia.2008.06.013
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kilner James M, 2007, Cogn Process, V8, P159, DOI 10.1007/s10339-007-0170-2
   Liu YN, 2011, NEUROPSYCHOLOGIA, V49, P2105, DOI 10.1016/j.neuropsychologia.2011.04.005
   Marr D., 1982, VISION COMPUTATIONAL
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Pellicano E, 2012, TRENDS COGN SCI, V16, P504, DOI 10.1016/j.tics.2012.08.009
   Pellicano E, 2012, TRENDS COGN SCI, V16, P574, DOI 10.1016/j.tics.2012.10.004
   Plaisted KC, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P149
   Rao RPN, 1999, NAT NEUROSCI, V2, P79, DOI 10.1038/4580
   Rust NC, 2010, CURR OPIN NEUROBIOL, V20, P382, DOI 10.1016/j.conb.2010.04.013
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Colombo M, 2012, BRIT J PHILOS SCI, V63, P697, DOI 10.1093/bjps/axr043
   Zhang WW, 2009, NAT NEUROSCI, V12, P24, DOI 10.1038/nn.2223
NR 19
TC 10
Z9 10
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD JAN 28
PY 2013
VL 4
AR 19
DI 10.3389/fpsyg.2013.00019
PG 3
WC Psychology, Multidisciplinary
SC Psychology
GA AA0IB
UT WOS:000330777700001
PM 23372559
ER

PT J
AU Napoli, E
   Wong, S
   Giulivi, C
AF Napoli, Eleonora
   Wong, Sarah
   Giulivi, Cecilia
TI Evidence of reactive oxygen species-mediated damage to mitochondrial DNA
   in children with typical autism
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism; Mitochondria; Mitochondrial DNA; Oxidative damage; Bioenergetics
ID MULTIPLE MTDNA DELETIONS; GLUTATHIONE REDOX IMBALANCE; LIFE IMMUNE
   CHALLENGE; OXIDATIVE DAMAGE; HUMAN-CELLS; MAMMALIAN-CELLS; GENOME
   DATABASE; COPY NUMBER; BP DELETION; TISSUES
AB Background: The mitochondrial genome (mtDNA) is particularly susceptible to damage mediated by reactive oxygen species (ROS). Although elevated ROS production and elevated biomarkers of oxidative stress have been found in tissues from children with autism spectrum disorders, evidence for damage to mtDNA is lacking.
   Findings: mtDNA deletions were evaluated in peripheral blood monocytic cells (PBMC) isolated from 2-5 year old children with full autism (AU; n = 67), and typically developing children (TD; n = 46) and their parents enrolled in the CHildhood Autism Risk from Genes and Environment study (CHARGE) at University of California Davis. Sequence variants were evaluated in mtDNA segments from AU and TD children (n = 10; each) and their mothers representing 31.2% coverage of the entire human mitochondrial genome. Increased mtDNA damage in AU children was evidenced by (i) higher frequency of mtDNA deletions (2-fold), (ii) higher number of GC. AT transitions (2.4-fold), being GC preferred sites for oxidative damage, and (iii) higher frequency of G, C, T. A transitions (1.6-fold) suggesting a higher incidence of polymerase gamma incorporating mainly A at bypassed apurinic/ apyrimidinic sites, probably originated from oxidative stress. The last two outcomes were identical to their mothers suggesting the inheritance of a template consistent with increased oxidative damage, whereas the frequency of mtDNA deletions in AU children was similar to that of their fathers.
   Conclusions: These results suggest that a combination of genetic and epigenetic factors, taking place during perinatal periods, results in a mtDNA template in children with autism similar to that expected for older individuals.
C1 [Napoli, Eleonora; Wong, Sarah; Giulivi, Cecilia] Univ Calif Davis, Dept Mol Biosci, Davis, CA 95616 USA.
   [Giulivi, Cecilia] Univ Calif Davis, Med Invest Neurodev Disorders MIND Inst, Davis, CA 95616 USA.
RP Giulivi, C (reprint author), Univ Calif Davis, Dept Mol Biosci, 1 Shields Ave,1120 Haring Hall, Davis, CA 95616 USA.
EM cgiulivi@ucdavis.edu
FU University of California Davis [2444]; Autism Speaks [R01-ES011269,,
   NIEHS R01-ES015359, NIEHS R01-ES020392]
FX We wish to express our gratitude to the children and their families who
   participated in this study; Ms Alicja Omanska-Klusek for technical
   assistance; Dr Flora Tassone for providing all samples utilized in this
   study; Dr Irva HertzPicciotto for providing diagnostic,
   sociodemographic, and comorbidity data, and Dr Isaac Pessah for
   providing input at early stages of the study. This study was performed
   under the funding from the 2008 M. I. N. D. Institute Pilot Research
   Grant, University of California Davis, # 2444 Autism Speaks, and NIEHS
   R01-ES011269, NIEHS R01-ES015359 and NIEHS R01-ES020392. The
   abovementioned funding agencies were not responsible for the design and
   conduct of the study, collection, management, analysis or interpretation
   of the data, or the preparation, review, or approval of this manuscript.
CR Albers DS, 2000, J NEURAL TRANSM-SUPP, P133
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4th
   Beckman KB, 1997, J BIOL CHEM, V272, P19633, DOI 10.1074/jbc.272.32.19633
   Betts J, 2006, NEUROPATH APPL NEURO, V32, P359, DOI 10.1111/j.1365-2990.2006.00731.x
   Boisse L, 2004, J NEUROSCI, V24, P4928, DOI 10.1523/JNEUROSCI.1077-04.2004
   Brandon MC, 2005, NUCLEIC ACIDS RES, V33, pD611
   Chabi B, 2005, BIOCHEM BIOPH RES CO, V332, P542, DOI 10.1016/j.bbrc.2005.04.153
   Chauhan A, 2012, NEUROCHEM RES, V37, P1681, DOI 10.1007/s11064-012-0775-4
   CORRALDEBRINSKI M, 1992, NAT GENET, V2, P324, DOI 10.1038/ng1292-324
   CORTOPASSI GA, 1992, P NATL ACAD SCI USA, V89, P7370, DOI 10.1073/pnas.89.16.7370
   Croteau DL, 1997, J BIOL CHEM, V272, P25409, DOI 10.1074/jbc.272.41.25409
   Davey GP, 1998, J BIOL CHEM, V273, P12753, DOI 10.1074/jbc.273.21.12753
   Ellis S, 2005, FASEB J, V19, P1519, DOI 10.1096/fj.04-3569fje
   Geier DA, 2009, J NEUROL SCI, V280, P101, DOI 10.1016/j.jns.2008.08.021
   Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
   Giulivi C, 1998, BBA-BIOENERGETICS, V1366, P265, DOI 10.1016/S0005-2728(98)00125-X
   GIULIVI C, 1995, ARCH BIOCHEM BIOPHYS, V316, P909, DOI 10.1006/abbi.1995.1122
   Giulivi C, 1997, REACTIVE OXYGEN SPEC, V77, P77
   Hao HL, 1999, HUM MOL GENET, V8, P1117, DOI 10.1093/hmg/8.6.1117
   He LP, 2002, NUCLEIC ACIDS RES, V30, DOI 10.1093/nar/gnf067
   Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
   HOLT IJ, 1989, ANN NEUROL, V26, P699, DOI 10.1002/ana.410260603
   Ingman M, 2006, NUCLEIC ACIDS RES, V34, pD749, DOI 10.1093/nar/gkj010
   James SJ, 2009, FASEB J, V23, P2374, DOI 10.1096/fj.08-128926
   James SJ, 2009, AM J CLIN NUTR, V89, P425, DOI 10.3945/ajcn.2008.26615
   Khrapko K, 1997, P NATL ACAD SCI USA, V94, P13798, DOI 10.1073/pnas.94.25.13798
   Kienhofer J, 2009, FASEB J, V23, P2034, DOI 10.1096/fj.08-113571
   Komulainen T, 2010, BMC NEUROL, V10, DOI 10.1186/1471-2377-10-29
   Kreutzer DA, 1998, P NATL ACAD SCI USA, V95, P3578, DOI 10.1073/pnas.95.7.3578
   LEE HC, 1994, BBA-MOL BASIS DIS, V1226, P37, DOI 10.1016/0925-4439(94)90056-6
   Le Page F, 1998, NUCLEIC ACIDS RES, V26, P1276, DOI 10.1093/nar/26.5.1276
   Lezza AMS, 1999, FASEB J, V13, P1083
   Lin MT, 2006, NATURE, V443, P787, DOI 10.1038/nature05292
   LINDAHL T, 1993, NATURE, V362, P709, DOI 10.1038/362709a0
   Loft S, 1999, METHOD ENZYMOL, V300, P166
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Marcelino LA, 1999, MUTAT RES-DNA REPAIR, V434, P177, DOI 10.1016/S0921-8777(99)00028-2
   Marcelino LA, 1998, CANCER RES, V58, P2857
   Melberg A, 2005, ACTA NEUROPATHOL, V110, P315, DOI 10.1007/s00401-005-1047-z
   Meng XM, 2005, NEUROLOGY, V64, P1644, DOI 10.1212/01.WNL.0000160391.58004.D4
   Ming X, 2008, AM J BIOCH BIOTECHNO, V4, P8
   Ming X, 2010, BRAIN DEV-JPN, V32, P105, DOI 10.1016/j.braindev.2008.12.017
   Morton BR, 2006, GENETICS, V172, P569, DOI 10.1534/genetics.105.049916
   Mullen E, 1995, MULLEN SCALES EARLY
   Napoli E, 2012, HUM MOL GENET, DOI [10.1093/hmg/dds503.epub 11/29/2012., DOI 10.1093/HMG/DDS503.EPUB]
   Napoli E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042504
   Parfait B, 1998, BIOCHEM BIOPH RES CO, V247, P57, DOI 10.1006/bbrc.1998.8666
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   PINZ KG, 1995, J BIOL CHEM, V270, P9202
   REID TM, 1994, ENVIRON HEALTH PERSP, V102, P57, DOI 10.2307/3431764
   Schmidt RJ, 2011, EPIDEMIOLOGY, V22, P476, DOI 10.1097/EDE.0b013e31821d0e30
   Shanks N, 2000, P NATL ACAD SCI USA, V97, P5645, DOI 10.1073/pnas.090571897
   Shelton JF, 2012, ENVIRON HEALTH PERSP, V120, P944, DOI 10.1289/ehp.1104553
   SHIBUTANI S, 1991, NATURE, V349, P431, DOI 10.1038/349431a0
   SPARROW SS, 1985, J PEDIATR PSYCHOL, V10, P215, DOI 10.1093/jpepsy/10.2.215
   Spencer SJ, 2005, BEHAV BRAIN RES, V164, P231, DOI 10.1016/j.bbr.2005.06.032
   Srivastava S, 2005, HUM MOL GENET, V14, P893, DOI 10.1093/hmg/ddi082
   Taylor RW, 2001, NUCLEIC ACIDS RES, V29, part. no., DOI 10.1093/nar/29.15.e74
   Wang Y, 2001, P NATL ACAD SCI USA, V98, P4022, DOI 10.1073/pnas.061013598
   Whittaker RG, 2007, DIABETOLOGIA, V50, P2085, DOI 10.1007/s00125-007-0779-9
   Wong TS, 2009, NUCLEIC ACIDS RES, V37, P568, DOI 10.1093/nar/gkn974
   WOOD ML, 1990, BIOCHEMISTRY-US, V29, P7024, DOI 10.1021/bi00482a011
   World Medical Association. World Medical Association Declaration of Helsinki, 2002, J POSTGRAD MED, V48, P206
   Yin PH, 2004, BRIT J CANCER, V90, P2390, DOI 10.1038/sj.bjc.6601838
   Yowe DL, 1998, GENE, V209, P23, DOI 10.1016/S0378-1119(97)00628-8
   Zeviani M, 2003, CURR OPIN GENET DEV, V13, P262, DOI 10.1016/S0959-437X(03)00052-2
   Zhang FK, 2004, GENOMICS, V84, P785, DOI 10.1016/j.ygeno.2004.06.015
NR 68
TC 15
Z9 15
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD JAN 25
PY 2013
VL 4
AR 2
DI 10.1186/2040-2392-4-2
PG 8
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254TY
UT WOS:000327191600001
PM 23347615
ER

PT J
AU Duffy, FH
   Eksioglu, YZ
   Rotenberg, A
   Madsen, JR
   Shankardass, A
   Als, H
AF Duffy, Frank H.
   Eksioglu, Yaman Z.
   Rotenberg, Alexander
   Madsen, Joseph R.
   Shankardass, Aditi
   Als, Heidelise
TI The frequency modulated auditory evoked response (FMAER), a technical
   advance for study of childhood language disorders: cortical source
   localization and selected case studies
SO BMC NEUROLOGY
LA English
DT Article
DE Frequency modulation; Auditory evoked response; FMAER; Cortical; Source
   analysis; Language disorder; Landau-Kleffner syndrome; Autism; Children;
   Epilepsy surgery
ID DEVELOPMENTAL DYSPHASIA; PRINCIPAL COMPONENTS; CHILDREN; TONES;
   STIMULATION; IMPAIRMENT; RESOLUTION; DEFICITS; APHASIA; EEG
AB Background: Language comprehension requires decoding of complex, rapidly changing speech streams. Detecting changes of frequency modulation (FM) within speech is hypothesized as essential for accurate phoneme detection, and thus, for spoken word comprehension. Despite past demonstration of FM auditory evoked response (FMAER) utility in language disorder investigations, it is seldom utilized clinically. This report's purpose is to facilitate clinical use by explaining analytic pitfalls, demonstrating sites of cortical origin, and illustrating potential utility.
   Results: FMAERs collected from children with language disorders, including Developmental Dysphasia, Landau-Kleffner syndrome (LKS), and autism spectrum disorder (ASD) and also normal controls - utilizing multi-channel reference-free recordings assisted by discrete source analysis - provided demonstratrions of cortical origin and examples of clinical utility. Recordings from inpatient epileptics with indwelling cortical electrodes provided direct assessment of FMAER origin. The FMAER is shown to normally arise from bilateral posterior superior temporal gyri and immediate temporal lobe surround. Childhood language disorders associated with prominent receptive deficits demonstrate absent left or bilateral FMAER temporal lobe responses. When receptive language is spared, the FMAER may remain present bilaterally. Analyses based upon mastoid or ear reference electrodes are shown to result in erroneous conclusions. Serial FMAER studies may dynamically track status of underlying language processing in LKS. FMAERs in ASD with language impairment may be normal or abnormal. Cortical FMAERs can locate language cortex when conventional cortical stimulation does not.
   Conclusion: The FMAER measures the processing by the superior temporal gyri and adjacent cortex of rapid frequency modulation within an auditory stream. Clinical disorders associated with receptive deficits are shown to demonstrate absent left or bilateral responses. Serial FMAERs may be useful for tracking language change in LKS. Cortical FMAERs may augment invasive cortical language testing in epilepsy surgical patients. The FMAER may be normal in ASD and other language disorders when pathology spares the superior temporal gyrus and surround but presumably involves other brain regions. Ear/mastoid reference electrodes should be avoided and multichannel, reference free recordings utilized. Source analysis may assist in better understanding of complex FMAER findings.
C1 [Duffy, Frank H.; Rotenberg, Alexander] Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA.
   [Duffy, Frank H.; Rotenberg, Alexander; Madsen, Joseph R.; Shankardass, Aditi; Als, Heidelise] Harvard Univ, Sch Med, Boston, MA 02115 USA.
   [Eksioglu, Yaman Z.] Golisano Childrens Hosp, Syracuse, NY 13202 USA.
   [Eksioglu, Yaman Z.] Upstate Med Univ, Syracuse, NY 13202 USA.
   [Madsen, Joseph R.] Boston Childrens Hosp, Dept Neurosurg, Boston, MA 02115 USA.
   [Shankardass, Aditi; Als, Heidelise] Boston Childrens Hosp, Dept Psychiat Psychol, Boston, MA 02115 USA.
RP Duffy, FH (reprint author), Boston Childrens Hosp, Dept Neurol, 300 Longwood Ave, Boston, MA 02115 USA.
EM fhd@sover.net
FU National Institutes of Health/National Institute of Child Health and
   Human Development [R01HD047730]; Intellectual and Developmental
   Disabilities Research Center (IDDRC) [P30HD018655]; Tommy Fuss Fund
FX The authors thank the research subjects and the patients, as well as
   their families for their participation in the studies performed. They
   further thank registered EEG technologists Herman Edwards, Jack Connolly
   and Sheryl Manganaro for the quality of their data acquisition and for
   their consistent efforts over the years. The authors thank Joseph
   Heydrich-Gonzalez, MD for making available several of the neurotypical
   control subjects in the 14 to 20 year old population. The professionals
   acknowledged performed their roles as part of their regular clinical and
   research obligations and were not additionally compensated for their
   contribution. This work was supported in part by National Institutes of
   Health/National Institute of Child Health and Human Development grant
   R01HD047730 to Heidelise Als, PhD and the Intellectual and Developmental
   Disabilities Research Center (IDDRC) grant P30HD018655 to Scott.
   Pomeroy, MD, PhD, Boston Children's Hospital and Harvard Medical School.
   The authors furthermore acknowledge support from the Tommy Fuss Fund to
   Joseph Gonzalez-Heydrich, MD, and thank the Chairmen of Neurology (Scott
   Pomeroy), Neurosurgery (Alan R. Cohen), and Psychiatry (David R. DeMaso)
   for their continuing support of these research efforts.
CR American Clinical Neurophysiology Society, 2006, J CLIN NEUROPHYSIOL, V23, P107
   BARTELS PH, 1981, ANAL QUANT CYTOL, V3, P83
   COOLEY W. W., 1971, MULTIVARIATE DATA AN
   de Ribaupierre S, 2012, EPILEPSIA, V53, P67, DOI 10.1111/j.1528-1167.2011.03329.x
   DUFFY FH, 1979, ANN NEUROL, V5, P309, DOI 10.1002/ana.410050402
   Duffy FH, 1999, CLIN ELECTROENCEPHAL, V30, P84
   Green GGR, 1979, J PHYSIOL-LONDON, V296, P21
   Green G.G.R., 1980, J PHYSL, V307
   GUTTMAN L, 1954, PSYCHOMETRIKA, V19, P149
   Hagenmuller F, 2011, HUM PSYCHOPHARM CLIN, V26, P147, DOI 10.1002/hup.1186
   Harpaz Y, 2009, CORTEX, V45, P1097, DOI 10.1016/j.cortex.2009.01.002
   JACKSON DA, 1993, ECOLOGY, V74, P2204, DOI 10.2307/1939574
   JAYAKAR P, 1992, J CLIN NEUROPHYSIOL, V9, P288, DOI 10.1097/00004691-199204010-00009
   KAY RH, 1972, J PHYSIOL-LONDON, V225, P657
   Kayser J, 2010, CLIN NEUROPHYSIOL, V121, P1973, DOI 10.1016/j.clinph.2010.04.030
   Lewine JD, 1999, PEDIATRICS, V104, P405, DOI 10.1542/peds.104.3.405
   Nagarajan S, 1999, P NATL ACAD SCI USA, V96, P6483, DOI 10.1073/pnas.96.11.6483
   Newman AJ, 2010, P NATL ACAD SCI USA, V107, P7539, DOI 10.1073/pnas.1003174107
   Nunez P. L., 1981, ELECT FIELDS BRAIN
   REGAN D, 1979, J ACOUST SOC AM, V65, P1249, DOI 10.1121/1.382792
   Saygin AP, 2003, BRAIN, V126, P928, DOI 10.1093/brain/awg082
   STEFANATOS GA, 1989, ARCH NEUROL-CHICAGO, V46, P871
   Stefanatos GA, 1997, EVOKED POTENTIAL, V104, P31, DOI 10.1016/S0168-5597(96)96042-6
   Stefanatos Gerry A., 2008, Seminars in Speech and Language, V29, P239, DOI 10.1055/s-0028-1082887
   STEFANATOS GA, 1993, ANN NY ACAD SCI, V682, P412, DOI 10.1111/j.1749-6632.1993.tb23009.x
   Takeoka M, 2004, NEUROLOGY, V63, P1289
   Talcott JB, 1999, NEUROREPORT, V10, P2045, DOI 10.1097/00001756-199907130-00010
   Tallal P., 1980, B ORTON SOC, V30, P170, DOI 10.1007/BF02653716
   TALLAL P, 1993, ANN NY ACAD SCI, V682, P27, DOI 10.1111/j.1749-6632.1993.tb22957.x
   Tallal P., 1993, ANN NEW YORK ACAD SC, V682
   TALLAL P, 1976, BRAIN LANG, V3, P305, DOI 10.1016/0093-934X(76)90025-0
   TALLAL P, 1980, NEUROPSYCHOLOGIA, V18, P273, DOI 10.1016/0028-3932(80)90123-2
   TOMBLIN JB, 1995, J SPEECH HEAR RES, V38, P387
   van Drongelen W, 2011, SIGNAL PROCESSING NE, V5
   Wright BA, 1997, NATURE, V387, P176, DOI 10.1038/387176a0
   Zangaladze A, 2008, EPILEPSIA, V49, P481, DOI 10.1111/j.1528-1167.2007.01307.x
NR 36
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2377
J9 BMC NEUROL
JI BMC Neurol.
PD JAN 25
PY 2013
VL 13
AR 12
DI 10.1186/1471-2377-13-12
PG 22
WC Clinical Neurology
SC Neurosciences & Neurology
GA 095MV
UT WOS:000315339500001
PM 23351174
ER

PT J
AU Kikuchi, M
   Yoshimura, Y
   Shitamichi, K
   Ueno, S
   Hirosawa, T
   Munesue, T
   Ono, Y
   Tsubokawa, T
   Haruta, Y
   Oi, M
   Niida, Y
   Remijn, GB
   Takahashi, T
   Suzuki, M
   Higashida, H
   Minabe, Y
AF Kikuchi, Mitsuru
   Yoshimura, Yuko
   Shitamichi, Kiyomi
   Ueno, Sanae
   Hirosawa, Tetsu
   Munesue, Toshio
   Ono, Yasuki
   Tsubokawa, Tsunehisa
   Haruta, Yasuhiro
   Oi, Manabu
   Niida, Yo
   Remijn, Gerard B.
   Takahashi, Tsutomu
   Suzuki, Michio
   Higashida, Haruhiro
   Minabe, Yoshio
TI A custom magnetoencephalography device reveals brain connectivity and
   high reading/decoding ability in children with autism
SO SCIENTIFIC REPORTS
LA English
DT Article
ID 2-TO 5-YEAR-OLD CHILDREN; HIGH-FUNCTIONING AUTISM; WORKING-MEMORY TASK;
   GAMMA-BAND ACTIVITY; SPECTRUM DISORDERS; VISUAL-CORTEX; SENTENCE
   COMPREHENSION; LANGUAGE PERFORMANCE; HIGH-FREQUENCY; FMRI
AB A subset of individuals with autism spectrum disorder (ASD) performs more proficiently on certain visual tasks than may be predicted by their general cognitive performances. However, in younger children with ASD (aged 5 to 7), preserved ability in these tasks and the neurophysiological correlates of their ability are not well documented. In the present study, we used a custom child-sized magnetoencephalography system and demonstrated that preserved ability in the visual reasoning task was associated with rightward lateralisation of the neurophysiological connectivity between the parietal and temporal regions in children with ASD. In addition, we demonstrated that higher reading/decoding ability was also associated with the same lateralisation in children with ASD. These neurophysiological correlates of visual tasks are considerably different from those that are observed in typically developing children. These findings indicate that children with ASD have inherently different neural pathways that contribute to their relatively preserved ability in visual tasks.
C1 [Kikuchi, Mitsuru; Yoshimura, Yuko; Munesue, Toshio; Oi, Manabu; Niida, Yo; Higashida, Haruhiro; Minabe, Yoshio] Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa 9208640, Japan.
   [Kikuchi, Mitsuru; Shitamichi, Kiyomi; Ueno, Sanae; Hirosawa, Tetsu; Munesue, Toshio; Ono, Yasuki; Minabe, Yoshio] Kanazawa Univ, Grad Sch Med Sci, Dept Psychiat, Kanazawa, Ishikawa 9208640, Japan.
   [Kikuchi, Mitsuru; Shitamichi, Kiyomi; Ueno, Sanae; Hirosawa, Tetsu; Munesue, Toshio; Ono, Yasuki; Minabe, Yoshio] Kanazawa Univ, Grad Sch Med Sci, Dept Neurobiol, Kanazawa, Ishikawa 9208640, Japan.
   [Kikuchi, Mitsuru; Yoshimura, Yuko; Munesue, Toshio; Oi, Manabu; Higashida, Haruhiro; Minabe, Yoshio] Chiba Univ, Hamamatsu Univ Sch Med, Dept Child Dev, United Grad Sch Child Dev,Osaka Univ,Kanazawa Uni, Kanazawa, Ishikawa 9208640, Japan.
   [Kikuchi, Mitsuru; Yoshimura, Yuko; Munesue, Toshio; Oi, Manabu; Higashida, Haruhiro; Minabe, Yoshio] Univ Fukui, Kanazawa, Ishikawa 9208640, Japan.
   [Remijn, Gerard B.] Kyushu Univ, Int Educ Ctr, Fukuoka 8158545, Japan.
   [Tsubokawa, Tsunehisa] Kanazawa Univ, Grad Sch Med Sci, Dept Anaesthesiol, Kanazawa, Ishikawa 9208640, Japan.
   [Haruta, Yasuhiro] Yokogawa Elect Corp, Dept MEG, Kanazawa, Ishikawa 9200177, Japan.
   [Takahashi, Tsutomu; Suzuki, Michio] Toyama Univ, Sch Med, Dept Neuropsychiat, Toyama 9300194, Japan.
RP Kikuchi, M (reprint author), Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa 9208640, Japan.
EM mitsuru@zc4.so-net.ne.jp
FU Hokuriku Innovation Cluster for Health Science (MEXT Program for
   Fostering Regional Innovation); Strategic Research Program for Brain
   Sciences from MEXT, Japan
FX This study was supported by the Hokuriku Innovation Cluster for Health
   Science (MEXT Program for Fostering Regional Innovation) and by the
   Strategic Research Program for Brain Sciences from MEXT, Japan. The
   authors declare that they have no conflicts of interest.
CR Anderson JS, 2011, BRAIN, V134, P3739, DOI 10.1093/brain/awr263
   [Anonymous], 1994, DIAGNOSTIC STAT MANU
   Beauchamp MS, 2012, NAT NEUROSCI, V15, P957, DOI 10.1038/nn.3131
   Bitan T, 2009, J COGNITIVE NEUROSCI, V21, P1135, DOI 10.1162/jocn.2009.21065
   Brem S, 2010, P NATL ACAD SCI USA, V107, P7939, DOI 10.1073/pnas.0904402107
   Brookes MJ, 2005, NEUROIMAGE, V26, P302, DOI 10.1016/j.neuroimage.2005.01.050
   Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
   Cohen L, 2003, CEREB CORTEX, V13, P1313, DOI 10.1093/cercor/bhg079
   Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
   De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
   Duncan J, 2000, SCIENCE, V289, P457, DOI 10.1126/science.289.5478.457
   Everts R, 2009, HUM BRAIN MAPP, V30, P473, DOI 10.1002/hbm.20523
   Eyler LT, 2012, BRAIN, V135, P949, DOI 10.1093/brain/awr364
   Fox PT, 2012, NEUROIMAGE, V61, P407, DOI 10.1016/j.neuroimage.2011.12.051
   Gage NM, 2009, J NEURODEV DISORD, V1, P205, DOI 10.1007/s11689-009-9010-2
   GASSER T, 1987, ELECTROEN CLIN NEURO, V67, P151, DOI 10.1016/0013-4694(87)90038-1
   Gregoriou GG, 2009, SCIENCE, V324, P1207, DOI 10.1126/science.1171402
   Gudmundsson S, 2007, CLIN NEUROPHYSIOL, V118, P2162, DOI 10.1016/j.clinph.2007.06.018
   Holz EM, 2010, NEUROIMAGE, V52, P326, DOI 10.1016/j.neuroimage.2010.04.003
   Hutsler J, 2003, TRENDS NEUROSCI, V26, P429, DOI 10.1016/S0166-2236(03)00198-X
   Jensen O, 2007, TRENDS NEUROSCI, V30, P317, DOI 10.1016/j.tins.2007.05.001
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164
   Kaufman AS, 1983, KAUFMAN ASSESSMENT B
   Keehn B, 2008, J INT NEUROPSYCH SOC, V14, P990, DOI 10.1017/S1355617708081356
   Keil A, 1999, J NEUROSCI, V19, P7152
   Kikuchi M, 2011, J NEUROSCI, V31, P14984, DOI 10.1523/JNEUROSCI.2785-11.2011
   Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
   Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028
   Kroger JK, 2002, CEREB CORTEX, V12, P477, DOI 10.1093/cercor/12.5.477
   Lee KH, 2006, NEUROIMAGE, V29, P578, DOI 10.1016/j.neuroimage.2005.07.036
   Lee PS, 2009, CEREB CORTEX, V19, P1787, DOI 10.1093/cercor/bhn209
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Manjaly ZM, 2007, NEUROIMAGE, V35, P283, DOI 10.1016/j.neuroimage.2006.11.036
   Morsanyi K, 2010, DEVELOPMENTAL SCI, V13, P578, DOI 10.1111/j.1467-7687.2009.00915.x
   Mottron L, 2011, NATURE, V479, P33, DOI 10.1038/479033a
   Newman TM, 2007, J AUTISM DEV DISORD, V37, P760, DOI 10.1007/s10803-006-0206-y
   Orekhova EV, 2007, BIOL PSYCHIAT, V62, P1022, DOI 10.1016/j.biopsych.2006.12.029
   Prabhakaran V, 1997, COGNITIVE PSYCHOL, V33, P43, DOI 10.1006/cogp.1997.0659
   Privman E, 2011, CEREB CORTEX, V21, P616, DOI 10.1093/cercor/bhq128
   Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305
   Rojas DC, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-11
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Samson F., 2011, HUM BRAIN MAPP
   Sauseng P, 2004, NEUROSCI LETT, V354, P123, DOI 10.1016/j.neulet.2003.10.002
   Schalock RL, 2007, INTELLECT DEV DISAB, V45, P116, DOI 10.1352/1934-9556(2007)45[116:TROMRU]2.0.CO;2
   Sederberg PB, 2003, J NEUROSCI, V23, P10809
   Sohal VS, 2009, NATURE, V459, P698, DOI 10.1038/nature07991
   Sokolov A, 1999, NEUROREPORT, V10, P1997, DOI 10.1097/00001756-199907130-00001
   Soulieres I, 2009, HUM BRAIN MAPP, V30, P4082, DOI 10.1002/hbm.20831
   Spreen O., 1998, COMPENDIUM NEUROPSYC
   Stroganova TA, 2012, CORTEX, V48, P701, DOI 10.1016/j.cortex.2011.02.016
   Sun LM, 2012, J NEUROSCI, V32, P9563, DOI 10.1523/JNEUROSCI.1073-12.2012
   Tallon-Baudry C, 1999, TRENDS COGN SCI, V3, P151, DOI 10.1016/S1364-6613(99)01299-1
   van der Mark S, 2011, NEUROIMAGE, V54, P2426, DOI 10.1016/j.neuroimage.2010.10.002
   Wang XJ, 2010, PHYSIOL REV, V90, P1195, DOI 10.1152/physrev.00035.2008
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
   Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
   Yoshimura Y, 2012, EUR J NEUROSCI, V35, P644, DOI 10.1111/j.1460-9568.2012.07998.x
   Zion-Golumbic E, 2007, CEREB CORTEX, V17, P1741, DOI 10.1093/cercor/bhl100
NR 60
TC 9
Z9 10
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 25
PY 2013
VL 3
AR 1139
DI 10.1038/srep01139
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 081WT
UT WOS:000314353800001
PM 23355952
ER

PT J
AU Said, CP
   Egan, RD
   Minshew, NJ
   Behrmann, M
   Heeger, DJ
AF Said, Christopher P.
   Egan, Ryan D.
   Minshew, Nancy J.
   Behrmann, Marlene
   Heeger, David J.
TI Normal binocular rivalry in autism: Implications for the
   excitation/inhibition imbalance hypothesis
SO VISION RESEARCH
LA English
DT Article
DE Binocular rivalry; Psychophysics; Computational model; Autism
ID VISUAL-PERCEPTION; TRAVELING-WAVES; CHILDREN; EPILEPSY; CORTEX; MODEL;
   HYPERSENSITIVITY; ABNORMALITIES; COMMUNICATION; INDIVIDUALS
AB Autism is characterized by disruption in multiple dimensions of perception, emotion, language and social cognition. Many hypotheses for the underlying neurophysiological basis have been proposed. Among these is the excitation/inhibition (E/I) imbalance hypothesis, which states that levels of cortical excitation and inhibition are disrupted in autism. We tested this theory in the visual system, because vision is one of the better understood systems in neuroscience, and because the Ell imbalance theory has been proposed to explain hypersensitivity to sensory stimuli in autism. We conducted two experiments on binocular rivalry, a well-studied psychophysical phenomenon that depends critically on excitation and inhibition levels in cortex. Using a computational model, we made specific predictions about how imbalances in excitation and inhibition levels would affect perception during two aspects of binocular rivalry: mixed perception (Experiment 1) and traveling waves (Experiment 2). We found no significant differences in either of these phenomena between high-functioning adults with autism and controls, and no evidence for a relationship between these measurements and the severity of autism. These results do not conclusively rule out an excitation/inhibition imbalance in the visual system of those with autism, but they suggest that such an imbalance, if it exists, is likely to be small in magnitude. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Said, Christopher P.; Heeger, David J.] NYU, Ctr Neural Sci, New York, NY 10003 USA.
   [Said, Christopher P.; Heeger, David J.] NYU, Dept Psychol, New York, NY 10003 USA.
   [Egan, Ryan D.; Behrmann, Marlene] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
   [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15260 USA.
   [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15260 USA.
RP Said, CP (reprint author), 21 Washington Sq N,Apt 4R, New York, NY 10011 USA.
EM chris.said@gmail.com
FU Simons Foundation Autism Research Initiative [177638]; NIH/NICHD
   University of Pittsburgh Autism Center of Excellence [HD055748]
FX This research was funded by a grant from the Simons Foundation Autism
   Research Initiative (177638) awarded to David Heeger and Marlene
   Behrmann and by the NIH/NICHD University of Pittsburgh Autism Center of
   Excellence (HD055748). We thank Caroline Elizabeth Robertson and Chris
   Baker for their comments on an earlier version of this manuscript.
CR Asperger H., 1991, AUTISM ASPERGER SYND
   Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
   Baron-Cohen Simon, 2000, UNDERSTANDING OTHER
   Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001
   Blake R., 2005, BINOCULAR RIVALRY
   Blake R, 2002, NAT REV NEUROSCI, V3, P13, DOI 10.1038/nrn701
   Brascamp JW, 2006, J VISION, V6, P1244, DOI 10.1167/6.11.8
   Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
   Dinstein I, 2012, NEURON, V75, P981, DOI 10.1016/j.neuron.2012.07.026
   Dinstein I, 2010, NEURON, V66, P461, DOI 10.1016/j.neuron.2010.03.034
   Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
   Gomot M, 2002, PSYCHOPHYSIOLOGY, V39, P577, DOI 10.1017/S0048577202394058
   Perreault A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019519
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Hasson U, 2009, AUTISM RES, V2, P220, DOI 10.1002/aur.89
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
   Jamain S, 2002, MOL PSYCHIATR, V7, P302, DOI 10.1038/sj/mp/4000979
   Jones RSP, 2003, J INTELLECT DEV DIS, V28, P112, DOI 10.1080/1366825031000147058
   Kang MS, 2010, J VISION, V10, DOI 10.1167/10.11.3
   Kanner L, 1943, NERV CHILD, V2, P217
   Kern JK, 2006, AUTISM, V10, P480, DOI 10.1177/1362361306066564
   Lee SH, 2007, NAT NEUROSCI, V10, P1048, DOI 10.1038/nn1939
   Lee SH, 2005, NAT NEUROSCI, V8, P22, DOI 10.1038/nn1365
   Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
   LEHKY SR, 1988, PERCEPTION, V17, P215, DOI 10.1068/p170215
   Levelt W. J. M., 1965, BINOCULAR RIVALRY
   Levisohn PM, 2007, EPILEPSIA, V48, P33, DOI 10.1111/j.1528-1167.2007.01399.x
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Markram Henry, 2007, Front Neurosci, V1, P77, DOI 10.3389/neuro.01.1.1.006.2007
   Milne E, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00051
   Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303
   Moldin S. O., 2006, UNDERSTANDING AUTISM
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613
   ROSSI PG, 1995, BRAIN DEV-JPN, V17, P169, DOI 10.1016/0387-7604(95)00019-8
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846
   Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Tomchek SD, 2007, AM J OCCUP THER, V61, P190
   Tong F, 1998, NEURON, V21, P753, DOI 10.1016/S0896-6273(00)80592-9
   Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6
   Vattikuti S, 2010, BIOL PSYCHIAT, V67, P672, DOI 10.1016/j.biopsych.2009.09.008
   Wheatstone C., 1838, PHILOS T ROY SOC LON, V128, P371, DOI DOI 10.1098/RSTL.1838.0019
   Williams DL, 2006, CHILD NEUROPSYCHOL, V12, P279, DOI 10.1080/09297040600681190
   Wilson HR, 2001, NATURE, V412, P907, DOI 10.1038/35091066
NR 52
TC 10
Z9 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0042-6989
J9 VISION RES
JI Vision Res.
PD JAN 25
PY 2013
VL 77
BP 59
EP 66
DI 10.1016/j.visres.2012.11.002
PG 8
WC Neurosciences; Ophthalmology
SC Neurosciences & Neurology; Ophthalmology
GA 076ZC
UT WOS:000313996700008
PM 23200868
ER

PT J
AU Gardner, DM
   Murphy, AL
   Kutcher, S
   Beaulieu, S
   Carandang, C
   Labelle, A
   Lalonde, P
   Malla, A
   Milliken, H
   O'Donovan, C
   Schaffer, A
   Soni, J
   Taylor, VH
   Williams, R
AF Gardner, David M.
   Murphy, Andrea L.
   Kutcher, Stan
   Beaulieu, Serge
   Carandang, Carlo
   Labelle, Alain
   Lalonde, Pierre
   Malla, Ashok
   Milliken, Heather
   O'Donovan, Claire
   Schaffer, Ayal
   Soni, Jorge
   Taylor, Valerie H.
   Williams, Richard
TI Evidence review and clinical guidance for the use of ziprasidone in
   Canada
SO ANNALS OF GENERAL PSYCHIATRY
LA English
DT Review
DE Ziprasidone; Expert consensus; Schizophrenia; Bipolar disorder;
   Depression; Anxiety; Dosing; Off-label
ID MAJOR DEPRESSIVE DISORDER; NEUROLEPTIC MALIGNANT SYNDROME; INDUCED
   WEIGHT-GAIN; LONG-TERM TREATMENT; BIPOLAR-I DISORDER; ATYPICAL
   ANTIPSYCHOTIC MEDICATION; PSYCHIATRY WFSBP GUIDELINES; INDUCED
   TARDIVE-DYSKINESIA; AUTISM SPECTRUM DISORDERS; ANXIETY TREATMENTS CANMAT
AB While indicated for schizophrenia and acute mania, ziprasidone's evidence base and use in clinical practice extends beyond these regulatory approvals. We, an invited panel of experts led by a working group of 3, critically examined the evidence and our collective experience regarding the effectiveness, tolerability and safety of ziprasidone across its clinical uses. There was no opportunity for manufacturer input into the content of the review. As anticipated, ziprasidone was found to be effective for its indicated uses, although its utility in mania and mixed states lacked comparative data. Beyond these uses, the available data were either unimpressive or were lacking. An attractive characteristic is its neutral effect on weight thereby providing patients with a non-obesogenic long-term treatment option. Key challenges in practice include the need for dosing on a full stomach and managing its early onset adverse effect of restlessness. Addressing these issues are critical to its long-term success
C1 [Gardner, David M.; Murphy, Andrea L.; Kutcher, Stan; Carandang, Carlo; Milliken, Heather; O'Donovan, Claire] Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada.
   [Beaulieu, Serge; Malla, Ashok] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Labelle, Alain] Univ Ottawa, Dept Psychiat, Ottawa, ON K1N 6N5, Canada.
   [Lalonde, Pierre] Hop Louis H Lafontaine, Ctr Rech Fernand Seguin, Montreal, PQ, Canada.
   [Schaffer, Ayal; Soni, Jorge; Taylor, Valerie H.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Williams, Richard] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
RP Gardner, DM (reprint author), Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada.
EM david.gardner@dal.ca
FU Pfizer; Astra Zeneca; Biovail; BMS; Eli Lilly; Janssen-Ortho; Lundbeck;
   Merck-Frosst; Novartis; Servier; Pfizer Canada
FX Dr. David Gardner has been involved with the advisory board for
   JanssenOrtho and has received education grant funding from Pfizer for
   this project. Dr. Serge Beaulieu has been a speaker for Astra Zeneca,
   Biovail, Bristol Myers Squibb (BMS), Eli Lilly, GlaxoSmithKline (GSK),
   Janssen-Ortho, Lundbeck, Organon, Oryx, Pfizer, Wyeth. He has acted on
   the advisory board and/or as a consultant for Astra Zeneca, BMS, Eli
   Lilly, GSK, Janssen-Ortho, Lundbeck, Oryx, Otsuka, Schering-Plough
   Merck, Pfizer. He has also received research support from Astra Zeneca,
   Biovail, BMS, Eli Lilly, Janssen-Ortho, Lundbeck, Merck-Frosst,
   Novartis, Pfizer, and Servier.This consensus project was supported by a
   grant from Pfizer Canada who is the manufacturer of ziprasidone. Other
   than providing funding for the consensus review Pfizer had no
   involvement in the project. No employee of Pfizer saw any content of the
   manuscript prior to its publications. We would like to thank Dave Carter
   of Multidimensional Healthcare as well as Christina Clark and Kathryn
   Landry for their logistical and research support throughout the project.
CR Addington DE, 2009, CAN J PSYCHIAT, V54, P46
   Addington DEN, 2004, J CLIN PSYCHIAT, V65, P1624
   Akkaya C, 2007, J PSYCHOPHARMACOL, V21, P550, DOI 10.1177/0269881106075273
   Alipour A, 2010, J CLIN PSYCHOPHARM, V30, P76, DOI 10.1097/JCP.0b013e3181c914d3
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Alptekin K, 2009, INT CLIN PSYCHOPHARM, V24, P229, DOI 10.1097/YIC.0b013e32832c2624
   ALTAR CA, 1986, BRAIN RES BULL, V16, P517
   Alvarez-Jimenez M, 2010, SCHIZOPHR RES, V116, P16, DOI 10.1016/j.schres.2009.10.012
   Ananth J, 2004, J PSYCHIATR NEUROSCI, V29, P467
   [Anonymous], 2010, PFIZ CAN INC ZELD PR
   Aparasu Rajender R, 2007, Curr Med Res Opin, V23, P49, DOI 10.1185/030079906X158075
   Ballard C, 2006, COCHRANE DB SYST REV, V1, P1, DOI DOI 10.1002/14651858.CD003476.PUB2
   Baptista T, 1999, ACTA PSYCHIAT SCAND, V100, P3, DOI 10.1111/j.1600-0447.1999.tb10908.x
   Barbee JG, 2004, J CLIN PSYCHIAT, V65, P975
   Bauer M, 2009, J CLIN PSYCHIAT, V70, P540
   Blair J, 2005, J AM ACAD CHILD PSY, V44, P73, DOI 10.1097/01.chi.0000145372.61239.bb
   Boidi G, 2007, HUM PSYCHOPHARM CLIN, V22, P299, DOI 10.1002/hup.844
   Borovicka MC, 2006, ANN PHARMACOTHER, V40, P139, DOI 10.1345/aph.1G470
   Boter H, 2010, J CLIN PSYCHIAT, V71, P58, DOI 10.4088/JCP.08m04506yel
   Boter H, 2009, SCHIZOPHR RES, V115, P97, DOI 10.1016/j.schres.2009.09.019
   Bowden CL, 2010, J CLIN PSYCHIAT, V71, P130, DOI 10.4088/JCP.09m05482yel
   Bravo Vergel Y, 2007, HEALTH TECHNOL ASSES, V11, pix
   Bremner JD, 2003, JAMA-J AM MED ASSOC, V289, P3125, DOI 10.1001/jama.289.23.3125
   Bristol-Myers Squibb Canada, 2011, BRIST MYERS SQUIBB C
   Byerly MJ, 2007, PSYCHIAT SERV, V58, P844, DOI 10.1176/appi.ps.58.6.844
   Bymaster FP, 2002, NEUROPSYCHOPHARMACOL, V27, P699, DOI 10.1016/S0893-133X(02)00346-9
   Calabrese JR, 2005, AM J PSYCHIAT, V162, P1351, DOI 10.1176/appi.ajp.162.7.1351
   Canada Vigilance Health Canada, 2010, ZELD SUMM REP ADV RE
   Canadian Psychiatric Association, 2005, CAN J PSYCHIAT S1, V50, p7S
   Cedars-Sinai Medical Center, TREATM MAJ DEPR DIS
   Chung AK, 2010, J PSYCHOPHARMACOL, V25, P646
   Cipriani A, 2010, J PSYCHOPHARMACOL, V24, P1729, DOI 10.1177/0269881109106900
   Citrome L, 2009, ADV THER, V26, P739, DOI 10.1007/s12325-009-0055-0
   Citrome L, 2009, SCHIZOPHR RES, V115, P115, DOI 10.1016/j.schres.2009.09.023
   Citrome L, 2011, EXPERT OPIN DRUG SAF, V10, P437, DOI 10.1517/14740338.2011.560114
   Citrome L, 2009, SCHIZOPHR RES, V111, P39, DOI 10.1016/j.schres.2009.03.009
   Cooper WO, 2006, AMBUL PEDIATR, V6, P79, DOI 10.1016/j.ambp.2005.11.002
   Cooper WO, 2004, ARCH PEDIAT ADOL MED, V158, P753, DOI 10.1001/archpedi.158.8.753
   Correll CU, 2005, J CLIN PSYCHIAT, V66, P1331
   Davidson M, 2009, AM J PSYCHIAT, V166, P675, DOI 10.1176/appi.ajp.2008.08060806
   De Hert M, 2011, EUR PSYCHIAT, V26, P144, DOI 10.1016/j.eurpsy.2010.09.011
   DelBello MP, 2008, J CHILD ADOL PSYCHOP, V18, P491, DOI 10.1089/cap.2008.008
   DeLeon A, 2004, CLIN THER, V26, P649, DOI 10.1016/S0149-2918(04)90066-5
   Deng C, 2010, PROG NEURO-PSYCHOPH, V34, P1, DOI 10.1016/j.pnpbp.2009.11.009
   Duke University, ZIPR VS SERTR HAL PS
   Dunner DL, 2007, J CLIN PSYCHIAT, V68, P1071
   Eker SS, 2009, J PSYCHOPHARMACOL, V23, P993, DOI 10.1177/0269881108093843
   Elbe Dean, 2008, J Can Acad Child Adolesc Psychiatry, V17, P220
   Fagiolini A, 2010, EXPERT OPIN PHARMACO, V11, P2199, DOI 10.1517/14656566.2010.507630
   Ferket BS, 2010, ARCH INTERN MED, V170, P27, DOI 10.1001/archinternmed.2009.434
   Foley DL, 2011, ARCH GEN PSYCHIAT, V68, P609, DOI 10.1001/archgenpsychiatry.2011.2
   Foussias G, 2010, CAN J PSYCHIAT, V55, P117
   Fox MH, 2000, AM J MED QUAL, V15, P126, DOI 10.1177/106286060001500402
   Galderisi S, 2009, SCHIZOPHR RES, V115, P104, DOI 10.1016/j.schres.2009.09.022
   Gardner DM, GARDNERS EFFECT SIZE
   Gardner DM, 2010, AM J PSYCHIAT, V167, P686, DOI 10.1176/appi.ajp.2009.09060802
   Gentile S, 2009, OBES REV, V10, P527, DOI 10.1111/j.1467-789X.2009.00589.x
   Gentile S, 2010, PSYCHOPHARMACOLOGY, V212, P119, DOI 10.1007/s00213-010-1939-z
   Gjerden P, 2010, EUR J CLIN PHARMACOL, V66, P911, DOI 10.1007/s00228-010-0839-9
   Goldberg TE, 2009, AM J PSYCHIAT, V166, P631, DOI 10.1176/appi.ajp.2009.09040497
   Goodwin GM, 2009, J PSYCHOPHARMACOL, V23, P346, DOI 10.1177/0269881109102919
   Goodwin R, 2001, PSYCHIATR SERV, V52, P1081, DOI 10.1176/appi.ps.52.8.1081
   Greenhill LL, 2003, J AM ACAD CHILD PSY, V42, P627, DOI 10.1097/01.CH1.0000046841.56865.37
   Grunze H, 2010, WORLD J BIOL PSYCHIA, V11, P81, DOI 10.3109/15622970903555881
   Grunze H, 2009, WORLD J BIOL PSYCHIA, V10, P85, DOI 10.1080/15622970902823202
   Gupta Sanjay, 2008, Prim Care Companion J Clin Psychiatry, V10, P254
   Haddad PM, 2002, DRUGS, V62, P1649, DOI 10.2165/00003495-200262110-00006
   Haddad PM, 2007, CNS DRUGS, V21, P911
   Haffner SM, 2006, OBESITY, V14, p121S, DOI 10.1038/oby.2006.291
   Harrigan EP, 2004, J CLIN PSYCHOPHARM, V24, P62, DOI 10.1097/01.jcp.0000104913.75206.62
   Hermes E, 2011, SCHIZOPHR RES, V128, P166, DOI 10.1016/j.schres.2011.01.022
   Hosojima H, 2006, J PSYCHOPHARMACOL, V20, P75, DOI 10.1177/0269881105056647
   Jerrell JM, 2008, J CHILD NEUROL, V23, P1392, DOI 10.1177/0883073808319070
   Jhirwal O P, 2003, Indian J Psychiatry, V45, P64
   Johnsen E, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-26
   Jordan MP, 2003, J AM ACAD CHILD PSY, V42, P4, DOI 10.1097/01.CHI.0000024910.60748.9A
   Joyce AT, 2006, SCHIZOPHR RES, V83, P285, DOI 10.1016/j.schres.2006.01.009
   Kahn RS, 2008, LANCET, V371, P1085, DOI 10.1016/S0140-6736(08)60486-9
   Kaushik S, 2009, J CLIN PSYCHIAT, V70, P1326, DOI 10.4088/JCP.08l04400
   Keating AM, 2005, CLIN NEUROPHARMACOL, V28, P83, DOI 10.1097/01.wnf.0000159952.64640.28
   Keck PE, 2007, J CLIN PSYCHIAT, V68, P1480
   Keck PE, 2003, AM J PSYCHIAT, V160, P741, DOI 10.1176/appi.ajp.160.4.741
   Keefe RSE, 2007, ARCH GEN PSYCHIAT, V64, P633, DOI 10.1001/archpsyc.64.6.633
   Kemmler G, 2005, ARCH GEN PSYCHIAT, V62, P1305, DOI 10.1001/archpsyc.62.12.1305
   Ketter TA, 2010, J PSYCHIATR RES, V44, P8, DOI 10.1016/j.jpsychires.2009.07.006
   Khaled LA, 2003, PAEDIAT CHILD HLT SA, V8, p6A
   Komossa K, 2010, COCHRANE DB SYST REV, V12
   Komossa K, 2009, COCHRANE DB SYST REV, V4
   Kroeze WK, 2003, NEUROPSYCHOPHARMACOL, V28, P519, DOI 10.1038/sj.npp.1300027
   Kutcher Stan, 2005, Neuropsychiatr Dis Treat, V1, P89, DOI 10.2147/nedt.1.2.89.61042
   Lam RW, 2009, J AFFECT DISORDERS, V117, pS26, DOI 10.1016/j.jad.2009.06.041
   Leibold J, 2004, CLIN THER, V26, P1105, DOI 10.1016/S0149-2918(04)90182-8
   Leucht S, 2009, LANCET, V373, P31, DOI [10.1016/S0140-6736(08)61764-X, 10.1016/S01406736(08)61764-X]
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Lincoln J, 2010, J PSYCHIATR PRACT, V16, P103, DOI 10.1097/01.pra.0000369971.64908.dc
   Loebel AD, 2007, J CLIN PSYCHIAT, V68, P1333
   Lombardo I, 2012, J CLIN PSYCHOPHARM, V32, P470, DOI 10.1097/JCP.0b013e31825ccde5
   Maayan L, 2010, NEUROPSYCHOPHARMACOL, V35, P1520, DOI 10.1038/npp.2010.21
   MacIntosh D, SWITCH RX SWITCHING
   Mamo D, 2004, AM J PSYCHIAT, V161, P818, DOI 10.1176/appi.ajp.161.5.818
   Massachusetts General Hospital, ZIPR AUGM SSRIS PAT
   Massachusetts General Hospital, 12 WEEK PLAC CONTR T
   Mazei MS, 2002, BRAIN RES, V936, P58, DOI 10.1016/S0006-8993(02)02542-8
   MELTZER HY, 1991, SCHIZOPHRENIA BULL, V17, P263
   Mendhekar DN, 2005, CAN J PSYCHIAT, V50, P567
   Meyer JM, 2005, SCHIZOPHR RES, V80, P9, DOI 10.1016/j.schres.2005.07.015
   Miceli JJ, 2010, PHARMACOTHERAPY, V30, P127, DOI 10.1592/phco.30.2.127
   Miller DD, 2008, BRIT J PSYCHIAT, V193, P279, DOI 10.1192/bjp.bp.108.050088
   Moeller O, 2007, PROG NEURO-PSYCHOPH, V31, P1440, DOI 10.1016/j.pnpbp.2007.06.021
   Mohan T, 2009, J CLIN PSYCHIAT, V70, P1054, DOI 10.4088/JCP.08l04657
   Moisan J, 2010, CLIN THER, V32, pS21, DOI 10.1016/j.clinthera.2010.01.003
   Muller DJ, 2012, PHARMACOGENOMICS J, V12, P156, DOI 10.1038/tpj.2010.65
   Murty RG, 2002, J CLIN PSYCHOPHARM, V22, P624, DOI 10.1097/00004714-200212000-00015
   Myers SM, 2007, EXPERT OPIN PHARMACO, V8, P1579, DOI 10.1517/14656566.811.1579
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   Nelson JC, 2009, AM J PSYCHIAT, V166, P980, DOI 10.1176/appi.ajp.2009.09030312
   Neuhut R, 2009, J CHILD ADOL PSYCHOP, V19, P415, DOI 10.1089/cap.2008.0130
   Nierenberg AA, 2006, AM J PSYCHIAT, V163, P210, DOI 10.1176/appi.ajp.163.2.210
   Nyhuis AW, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-75
   Olfson M, 2011, SCHIZOPHR B, V38, P845
   Olfson M, 2006, ARCH GEN PSYCHIAT, V63, P679, DOI 10.1001/archpsyc.63.6.679
   Ozen ME, 2007, WORLD J BIOL PSYCHIA, V8, P42, DOI 10.1080/15622970600774202
   Pae CU, 2007, J CLIN PSYCHIAT, V68, P399
   Palik E, 2005, DIABETES RES CLIN PR, V68, pS60, DOI 10.1016/j.diabres.2005.03.008
   Papakostas GI, 2004, J CLIN PSYCHIAT, V65, P217
   Pappadopulos E, 2002, SCHIZOPHRENIA BULL, V28, P111
   Park JM, 2008, MASSACHUSETTS GEN CO
   Parsons B, 2009, SCHIZOPHR RES, V110, P103, DOI 10.1016/j.schres.2008.09.025
   Patel NC, 2005, J CHILD ADOL PSYCHOP, V15, P938, DOI 10.1089/cap.2005.15.938
   Patel NC, 2005, J AM ACAD CHILD PSY, V44, P548, DOI 10.1097/01.chi.0000157543.74509.c8
   Patel NC, 2002, J CHILD ADOL PSYCHOP, V12, P221, DOI 10.1089/104454602760386905
   Patel NC, 2006, ANN PHARMACOTHER, V40, P205, DOI 10.1345/aph.1G203
   Patkar A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034757
   Penfold RB, 2010, PEDIATRICS, V125, P475, DOI 10.1542/peds.2009-1288
   Perez-Iglesias R, 2010, J CLIN PSYCHOPHARM, V30, P661, DOI 10.1097/JCP.0b013e3181fae248
   Perlis RH, 2006, J CLIN PSYCHIAT, V67, P509
   Pfizer, 2009, GEOD PRESCR INF
   Pfizer Canada, COMM INV FUND CRIT G
   Pfizer Inc, 6 WEEK DOUBL BLIND M
   Pfizer Inc, 6 WEEK RAND DOUBL BL
   Potkin SG, 2009, INT J NEUROPSYCHOPH, V12, P1233, DOI 10.1017/S1461145709000352
   Potkin SG, 2005, J CLIN PSYCHOPHARM, V25, P301, DOI 10.1097/01.jcp.0000169068.34322.70
   Praharaj SK, 2011, BRIT J CLIN PHARMACO, V71, P377, DOI 10.1111/j.1365-2125.2010.03783.x
   Procyshyn RM, 2010, J CLIN PSYCHIAT, V71, P566, DOI 10.4088/JCP.08m04912gre
   Ramos AE, 2003, J AM ACAD CHILD PSY, V42, P1013, DOI 10.1097/01.CHI.0000070257.24125.91
   Rani F, 2008, PEDIATRICS, V121, P1002, DOI 10.1542/peds.2007-2008
   Ratner Y, 2007, PROG NEURO-PSYCHOPH, V31, P1401, DOI 10.1016/j.pnpbp.2007.06.008
   Reynolds Gavin P, 2006, J Psychopharmacol, V20, P15, DOI 10.1177/1359786806066040
   Rocha FL, 2006, DEMENT GERIATR COGN, V22, P445, DOI 10.1159/000095804
   Rosenheck RA, 2009, SCHIZOPHR RES, V107, P22, DOI 10.1016/j.schres.2008.09.031
   Rossi A, 2011, POSTGRAD MED, V123, P135, DOI 10.3810/pgm.2011.01.2255
   Rummel-Kluge C, 2012, SCHIZOPHRENIA BULL, V38, P167, DOI 10.1093/schbul/sbq042
   Rummel-Kluge C, 2010, SCHIZOPHR RES, V123, P225, DOI 10.1016/j.schres.2010.07.012
   Sacchetti E, 2009, SCHIZOPHR RES, V110, P80, DOI 10.1016/j.schres.2009.02.017
   Sachs GS, 2011, J CLIN PSYCHIAT, V72, P1413, DOI 10.4088/JCP.09m05934
   Saldana SN, 2007, J CHILD ADOL PSYCHOP, V17, P259, DOI 10.1089/cap.2006.0053
   Sallee FR, 2000, J AM ACAD CHILD PSY, V39, P292, DOI 10.1097/00004583-200003000-00010
   Scherk H, 2007, ARCH GEN PSYCHIAT, V64, P442, DOI 10.1001/archpsyc.64.4.442
   Schirm E, 2001, PEDIATRICS, V108, DOI 10.1542/peds.108.2.e25
   Schmidt AW, 2001, EUR J PHARMACOL, V425, P197, DOI 10.1016/S0014-2999(01)01188-8
   Schotte A, 1996, PSYCHOPHARMACOLOGY, V124, P57, DOI 10.1007/BF02245606
   SEEGER TF, 1995, J PHARMACOL EXP THER, V275, P101
   Shah RR, 2005, CARDIAC SAFETY OF NONCARDIAC DRUGS, P259, DOI 10.1007/978-1-59259-884-7_15
   Sicard MN, 2010, PHARMACOGENOMICS, V11, P1561, DOI [10.2217/pgs.10.123, 10.2217/PGS.10.123]
   Simon V, 2009, J CLIN PSYCHIAT, V70, P1041, DOI 10.4088/JCP.08r04392
   Sinha P, 2007, NATL MED J INDIA, V20, P271
   Snarr BS, 2010, ANN PHARMACOTHER, V44, P760, DOI 10.1345/aph.1M621
   Sproule BA, 2010, CAN J PSYCHIAT, V55, P248
   Stahl SM, 2003, J CLIN PSYCHIAT, V64, P6
   Stahl S, 2010, J AFFECT DISORDERS, V122, P39, DOI 10.1016/j.jad.2009.06.023
   Stahl SM, 2010, J CLIN PSYCHOPHARM, V30, P425, DOI 10.1097/JCP.0b013e3181e69042
   Tan HH, 2009, AM J EMERG MED, V27, P607, DOI 10.1016/j.ajem.2008.04.020
   Tatsumi M, 1999, EUR J PHARMACOL, V368, P277, DOI 10.1016/S0014-2999(99)00005-9
   Taylor DM, 2000, ACTA PSYCHIAT SCAND, V101, P416, DOI 10.1034/j.1600-0447.2000.101006416.x
   TECOTT LH, 1995, NATURE, V374, P542, DOI 10.1038/374542a0
   Thase ME, 2006, J CLIN PSYCHOPHARM, V26, P600, DOI 10.1097/01.jcp.0000248603.76231.b7
   Tohen M, 2003, ARCH GEN PSYCHIAT, V60, P1079, DOI 10.1001/archpsyc.60.11.1079
   Velligan Dawn I, 2009, J Clin Psychiatry, V70 Suppl 4, P1
   Velligan D. I., 2009, J CLIN PSYCHIAT S4, V70, P47
   Velligan DI, 2007, PSYCHIAT SERV, V58, P1187, DOI 10.1176/appi.ps.58.9.1187
   Verdoux H, 2010, ACTA PSYCHIAT SCAND, V121, P4, DOI 10.1111/j.1600-0447.2009.01425.x
   Vieta E, 2010, J PSYCHOPHARMACOL, V24, P547, DOI 10.1177/0269881108099418
   Vitiello B, 2003, J AM ACAD CHILD PSY, V42, P634, DOI 10.1097/01.CH1/0000046840.90931.36
   Vitiello B, 2009, EUR NEUROPSYCHOPHARM, V19, P629, DOI 10.1016/j.euroneuro.2009.04.008
   Weiden PJ, 2003, J CLIN PSYCHOPHARM, V23, P595, DOI 10.1097/01.jcp.0000095347.32154.08
   Weiden PJ, 2008, NEUROPSYCHOPHARMACOL, V33, P985, DOI 10.1038/sj.npp.1301482
   Weinmann S, 2009, SCHIZOPHR RES, V113, P1, DOI 10.1016/j.schres.2009.05.018
   Weisler R, 2003, ADJUNCTIVE ZIPRASIDO
   Yatham LN, 2009, BIPOLAR DISORD, V11, P225, DOI 10.1111/j.1399-5618.2009.00672.x
   Yildiz A, 2011, NEUROPSYCHOPHARMACOL, V36, P375, DOI 10.1038/npp.2010.192
   Zito JM, 1998, J CHILD ADOL PSYCHOP, V8, P99, DOI 10.1089/cap.1998.8.99
   Zito JM, 1998, J AM ACAD CHILD PSY, V37, P179, DOI 10.1097/00004583-199802000-00010
   Zito JM, 2000, JAMA-J AM MED ASSOC, V283, P1025, DOI 10.1001/jama.283.8.1025
NR 193
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1744-859X
J9 ANN GEN PSYCHIATR
JI Ann. Gen. Psychiatr.
PD JAN 24
PY 2013
VL 12
AR 1
DI 10.1186/1744-859X-12-1
PG 19
WC Psychiatry
SC Psychiatry
GA 085HF
UT WOS:000314605200001
PM 23347694
ER

PT J
AU Jia, MW
   Liu, YL
   Shen, ZC
   Zhao, C
   Zhang, MX
   Yi, ZH
   Wen, CP
   Deng, YP
   Shi, TL
AF Jia, Meiwei
   Liu, Yanli
   Shen, Zhongchao
   Zhao, Chen
   Zhang, Meixia
   Yi, Zhenghui
   Wen, Chengping
   Deng, Youping
   Shi, Tieliu
TI HDAM: a resource of human disease associated mutations from next
   generation sequencing studies
SO BMC MEDICAL GENOMICS
LA English
DT Article; Proceedings Paper
CT International Conference on Bioinformatics and Computational Biology
   (BIOCOMP)
CY JUL 18-21, 2011
CL Las Vegas, NV
ID AUTISM SPECTRUM DISORDERS; TOOL; INHERITANCE; ONTOLOGY; NETWORK
AB Background: Next generation sequencing (NGS) technologies have greatly facilitated the rapid and economical detection of pathogenic mutations in human disorders. However, mutation descriptions are hard to be compared and integrated due to various reference sequences and annotation tools adopted in different articles as well as the nomenclature of diseases/traits.
   Description: The Human Disease Associated Mutation (HDAM) database is dedicated to collect, standardize and re-annotate mutations for human diseases discovered by NGS studies. In the current release, HDAM contains 1,114 mutations, located in 669 genes and associated with 125 human diseases through literature mining. All mutation records have uniform and unequivocal descriptions of sequence changes according to the Human Genome Sequence Variation Society (HGVS) nomenclature recommendations. Each entry displays comprehensive information, including mutation location in genome (hg18/hg19), gene functional annotation, protein domain annotation, susceptible diseases, the first literature report of the mutation and etc. Moreover, new mutation-disease relationships predicted by Bayesian network are also presented under each mutation.
   Conclusion: HDAM contains hundreds rigorously curated human mutations from NGS studies and was created to provide a comprehensive view of these mutations that confer susceptibility to the common disorders. HDAM can be freely accessed at http://www.megabionet.org/HDAM.
C1 [Jia, Meiwei; Liu, Yanli; Shen, Zhongchao; Zhao, Chen; Shi, Tieliu] E China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Ctr Bioinformat & Computat Biol, Shanghai 200241, Peoples R China.
   [Jia, Meiwei; Liu, Yanli; Shen, Zhongchao; Zhao, Chen; Shi, Tieliu] E China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China.
   [Zhang, Meixia] Sichuan Univ, W China Hosp, Dept Ophthalmol, Chengdu 610041, Sichuan, Peoples R China.
   [Yi, Zhenghui] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Schizophrenia Program, Shanghai 200030, Peoples R China.
   [Wen, Chengping] Zhejiang Univ Chinese Med, TCM Clin Basis Inst, Hangzhou 310053, Zhejiang, Peoples R China.
   [Deng, Youping] Rush Univ, Dept Internal Med, Med Ctr, Ctr Canc, Chicago, IL 60612 USA.
RP Shi, TL (reprint author), E China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Ctr Bioinformat & Computat Biol, Shanghai 200241, Peoples R China.
EM tieliushi01@gmail.com
CR Ashburner M, 2000, NAT GENET, V25, P25
   Ayme S, 2007, BUNDESGESUNDHEITSBLA, V50, P1477, DOI 10.1007/s00103-007-0381-9
   Chua HN, 2006, BIOINFORMATICS, V22, P1623, DOI 10.1093/bioinformatics/btl145
   den Dunnen JT, 2000, HUM MUTAT, V15, P7
   George RA, 2006, NUCLEIC ACIDS RES, V34, DOI 10.1093/nar/gkl707
   Goh KI, 2007, P NATL ACAD SCI USA, V104, P8685, DOI 10.1073/pnas.0701361104
   Goriely A, 2009, NAT GENET, V41, P1247, DOI 10.1038/ng.470
   Hamosh A, 2005, NUCLEIC ACIDS RES, V33, pD514
   Jiang T, 2011, SCI CHINA LIFE SCI, V54, P945, DOI 10.1007/s11427-011-4232-4
   Jmol, OP SOURC JAV VIEW CH
   Kent WJ, 2002, GENOME RES, V12, P656, DOI 10.1101/gr.229202
   Mailman MD, 2007, NAT GENET, V39, P1181
   Ng SB, 2010, NAT GENET, V42, P30, DOI 10.1038/ng.499
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Rhodes DR, 2005, NAT BIOTECHNOL, V23, P951, DOI 10.1038/nbt1103
   Roach JC, 2010, SCIENCE, V328, P636, DOI 10.1126/science.1186802
   Robinson PN, 2008, AM J HUM GENET, V83, P610, DOI 10.1016/j.ajhg.2008.09.017
   Rosenspire A, 2011, AUTISM RES, V4, P242, DOI 10.1002/aur.194
   Wildeman M, 2008, HUM MUTAT, V29, P6, DOI 10.1002/humu.20654
   Wu JY, 2011, SCI CHINA LIFE SCI, V54, P290, DOI 10.1007/s11427-011-4148-z
   Yandell M, 2008, PLOS COMPUT BIOL, V4, DOI 10.1371/journal.pcbi.1000218
   Yu L, 2010, J BIOINFORM COMPUT B, V8, P47, DOI 10.1142/S0219720010005191
NR 22
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1755-8794
J9 BMC MED GENOMICS
JI BMC Med. Genomics
PD JAN 23
PY 2013
VL 6
SU 1
AR S16
DI 10.1186/1755-8794-6-S1-S16
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 083OF
UT WOS:000314473300016
PM 23369322
ER

PT J
AU Stein, JL
   Parikshak, NN
   Geschwind, DH
AF Stein, Jason L.
   Parikshak, Neelroop N.
   Geschwind, Daniel H.
TI Rare Inherited Variation in Autism: Beginning to See the Forest and a
   Few Trees
SO NEURON
LA English
DT Editorial Material
ID DE-NOVO MUTATIONS; SPECTRUM DISORDERS; VARIANTS
AB In this issue of Neuron, two papers (Lim et al., 2013; Yu et al., 2013) use whole-exome sequencing (WES) to elucidate the contribution of inherited variation to the risk for autism by leveraging the increased penetrance of homozygous and compound heterozygous rare variants in autosomes and hemizygous rare variants in the X chromosome of males. Together, they expand our knowledge about the genetic architecture of ASD, verify previously identified genes, and identify novel mutations that will guide the discovery of the critical biological processes disrupted in autism.
C1 [Stein, Jason L.; Parikshak, Neelroop N.; Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA.
   [Stein, Jason L.; Parikshak, Neelroop N.; Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Autism Res & Treatment, Semel Inst, Los Angeles, CA 90095 USA.
RP Geschwind, DH (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA.
EM dhg@mednet.ucla.edu
CR Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Berg JM, 2012, GENOME BIOL, V13, DOI [10.1186/gb4034, 10.1186/gb-2012-13-7-247]
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hosmer D., 2000, APPL LOGISTIC REGRES, P164
   Klei L, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-9
   Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
   lossifov I., 2012, NEURON, V74, P285
   Luo R, 2012, AM J HUM GENET, V91, P38, DOI 10.1016/j.ajhg.2012.05.011
   MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
   Michaelson JJ, 2012, CELL, V151, P1431, DOI 10.1016/j.cell.2012.11.019
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Novarino G, 2012, SCIENCE, V338, P394, DOI 10.1126/science.1224631
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
NR 15
TC 18
Z9 19
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD JAN 23
PY 2013
VL 77
IS 2
BP 209
EP 211
DI 10.1016/j.neuron.2013.01.010
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA 079VD
UT WOS:000314199400001
PM 23352155
ER

PT J
AU Lipton, J
   Sahin, M
AF Lipton, Jonathan
   Sahin, Mustafa
TI Fragile X Syndrome Therapeutics: Translation, Meet Translational
   Medicine
SO NEURON
LA English
DT Editorial Material
ID AUTISM
AB Fragile X syndrome, a common cause of intellectual disability and autism, is thought to occur due to abnormal regulation of neuronal protein synthesis. A study by Osterweil et al. (2013), in this issue, demonstrates that the HMG-CoA reductase inhibitor lovastatin can normalize protein synthesis and also reduce audiogenic seizures in Fmr1 knockout mice.
C1 [Lipton, Jonathan; Sahin, Mustafa] Harvard Univ, Sch Med, Boston Childrens Hosp, FM Kirby Neurobiol Ctr,Dept Neurol, Boston, MA 02115 USA.
RP Sahin, M (reprint author), Harvard Univ, Sch Med, Boston Childrens Hosp, FM Kirby Neurobiol Ctr,Dept Neurol, Boston, MA 02115 USA.
EM mustafa.sahin@childrens.harvard.edu
CR Acosta MT, 2011, PEDIATR NEUROL, V45, P241, DOI 10.1016/j.pediatrneurol.2011.06.016
   ASHLEY CT, 1993, SCIENCE, V262, P563, DOI 10.1126/science.7692601
   Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
   Bassell GJ, 2008, NEURON, V60, P201, DOI 10.1016/j.neuron.2008.10.004
   Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
   Berry-Kravis E, 2010, AJIDD-AM J INTELLECT, V115, P461, DOI [10.1352/1944-7558-115.6.461, 10.1352/194475581156461]
   Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
   Gross C, 2012, NEUROPSYCHOPHARMACOL, V37, P178, DOI 10.1038/npp.2011.137
   Weng N, 2008, AM J MED GENET B, V147B, P1253, DOI 10.1002/ajmg.b.30765
   Zhao WF, 2004, J NEUROSCI, V24, P76, DOI 10.1523/JNEUROSCI.4515-03.2004
NR 10
TC 2
Z9 2
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD JAN 23
PY 2013
VL 77
IS 2
BP 212
EP 213
DI 10.1016/j.neuron.2013.01.009
PG 2
WC Neurosciences
SC Neurosciences & Neurology
GA 079VD
UT WOS:000314199400002
PM 23352156
ER

PT J
AU Lim, ET
   Raychaudhuri, S
   Sanders, SJ
   Stevens, C
   Sabo, A
   MacArthur, DG
   Neale, BM
   Kirby, A
   Ruderfer, DM
   Fromer, M
   Lek, M
   Liu, L
   Flannick, J
   Ripke, S
   Nagaswamy, U
   Muzny, D
   Reid, JG
   Hawes, A
   Newsham, I
   Wu, YQ
   Lewis, L
   Dinh, H
   Gross, S
   Wang, LS
   Lin, CF
   Valladares, O
   Gabriel, SB
   dePristo, M
   Altshuler, DM
   Purcell, SM
   State, MW
   Boerwinkle, E
   Buxbaum, JD
   Cook, EH
   Gibbs, RA
   Schellenberg, GD
   Sutcliffe, JS
   Devlin, B
   Roeder, K
   Daly, MJ
AF Lim, Elaine T.
   Raychaudhuri, Soumya
   Sanders, Stephan J.
   Stevens, Christine
   Sabo, Aniko
   MacArthur, Daniel G.
   Neale, Benjamin M.
   Kirby, Andrew
   Ruderfer, Douglas M.
   Fromer, Menachem
   Lek, Monkol
   Liu, Li
   Flannick, Jason
   Ripke, Stephan
   Nagaswamy, Uma
   Muzny, Donna
   Reid, Jeffrey G.
   Hawes, Alicia
   Newsham, Irene
   Wu, Yuanqing
   Lewis, Lora
   Dinh, Huyen
   Gross, Shannon
   Wang, Li-San
   Lin, Chiao-Feng
   Valladares, Otto
   Gabriel, Stacey B.
   dePristo, Mark
   Altshuler, David M.
   Purcell, Shaun M.
   State, Matthew W.
   Boerwinkle, Eric
   Buxbaum, Joseph D.
   Cook, Edwin H.
   Gibbs, Richard A.
   Schellenberg, Gerard D.
   Sutcliffe, James S.
   Devlin, Bernie
   Roeder, Kathryn
   Daly, Mark J.
CA NHLBI Exome Sequencing Project
TI Rare Complete Knockouts in Humans: Population Distribution and
   Significant Role in Autism Spectrum Disorders
SO NEURON
LA English
DT Article
ID COPY-NUMBER VARIATION; DE-NOVO MUTATIONS; CANDIDATE GENES; SEQUENCING
   DATA; VARIANTS; GENOME; EXOME; ASSOCIATION; FAMILIES; BRAIN
AB To characterize the role of rare complete human knockouts in autism spectrum disorders (ASDs), we identify genes with homozygous or compound heterozygous loss-of-function (LoF) variants (defined as nonsense and essential splice sites) from exome sequencing of 933 cases and 869 controls. We identify a 2-fold increase in complete knockouts of autosomal genes with low rates of LoF variation (<= 5% frequency) in cases and estimate a 3% contribution to ASD risk by these events, confirming this observation in an independent set of 563 probands and 4,605 controls. Outside the pseudoautosomal regions on the X chromosome, we similarly observe a significant 1.5-fold increase in rare hemizygous knockouts in males, contributing to another 2% of ASDs in males. Taken together, these results provide compelling evidence that rare autosomal and X chromosome complete gene knockouts are important inherited risk factors for ASD.
C1 [Lim, Elaine T.; MacArthur, Daniel G.; Neale, Benjamin M.; Kirby, Andrew; Ruderfer, Douglas M.; Fromer, Menachem; Lek, Monkol; Flannick, Jason; Ripke, Stephan; Altshuler, David M.; Purcell, Shaun M.; Daly, Mark J.] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA.
   [Flannick, Jason; Altshuler, David M.] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA.
   [Ruderfer, Douglas M.; Fromer, Menachem; Purcell, Shaun M.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
   [Lim, Elaine T.; Raychaudhuri, Soumya; Stevens, Christine; MacArthur, Daniel G.; Neale, Benjamin M.; Kirby, Andrew; Ruderfer, Douglas M.; Fromer, Menachem; Lek, Monkol; Flannick, Jason; Ripke, Stephan; Gabriel, Stacey B.; dePristo, Mark; Altshuler, David M.; Purcell, Shaun M.; Daly, Mark J.] Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.
   [Lim, Elaine T.; Neale, Benjamin M.; Ruderfer, Douglas M.; Fromer, Menachem; Ripke, Stephan; Purcell, Shaun M.; Daly, Mark J.] Broad Inst, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.
   [Lim, Elaine T.; Raychaudhuri, Soumya; MacArthur, Daniel G.; Neale, Benjamin M.; Kirby, Andrew; Ruderfer, Douglas M.; Fromer, Menachem; Lek, Monkol; Flannick, Jason; Altshuler, David M.; Purcell, Shaun M.; Daly, Mark J.] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
   [Lim, Elaine T.; Raychaudhuri, Soumya; MacArthur, Daniel G.; Neale, Benjamin M.; Kirby, Andrew; Ruderfer, Douglas M.; Fromer, Menachem; Lek, Monkol; Flannick, Jason; Altshuler, David M.; Purcell, Shaun M.; Daly, Mark J.] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA.
   [Lim, Elaine T.] Harvard Univ, Sch Med, Program Genet & Genom Biol & Biomed Sci, Boston, MA 02115 USA.
   [Ruderfer, Douglas M.; Fromer, Menachem; Purcell, Shaun M.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Raychaudhuri, Soumya] Brigham & Womens Hosp, Div Immunol Allergy & Rheumatol, Boston, MA 02115 USA.
   [Sanders, Stephan J.; State, Matthew W.] Yale Univ, Dept Psychiat, Sch Med, New Haven, CT 06520 USA.
   [Sanders, Stephan J.; State, Matthew W.] Yale Univ, Dept Genet, Sch Med, New Haven, CT 06520 USA.
   [Sabo, Aniko; Nagaswamy, Uma; Muzny, Donna; Reid, Jeffrey G.; Hawes, Alicia; Newsham, Irene; Wu, Yuanqing; Lewis, Lora; Dinh, Huyen; Gross, Shannon; Boerwinkle, Eric; Gibbs, Richard A.] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.
   [Ruderfer, Douglas M.; Fromer, Menachem; Purcell, Shaun M.] Mt Sinai Sch Med, Div Psychiat Genom, New York, NY 10029 USA.
   [Buxbaum, Joseph D.] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
   [Ruderfer, Douglas M.; Fromer, Menachem; Purcell, Shaun M.; Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA.
   [Ruderfer, Douglas M.; Fromer, Menachem; Purcell, Shaun M.; Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USA.
   [Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA.
   [Buxbaum, Joseph D.] Mt Sinai Sch Med, Friedman Brain Inst, New York, NY 10029 USA.
   [Liu, Li; Roeder, Kathryn] Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA.
   [Liu, Li; Roeder, Kathryn] Carnegie Mellon Univ, Lane Ctr Computat Biol, Pittsburgh, PA 15213 USA.
   [Wang, Li-San; Lin, Chiao-Feng; Valladares, Otto] Univ Penn, Penn Ctr Bioinformat, Philadelphia, PA 19104 USA.
   [Schellenberg, Gerard D.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Boerwinkle, Eric] Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Houston, TX 77030 USA.
   [Cook, Edwin H.] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA.
   [Sutcliffe, James S.] Vanderbilt Univ, Vanderbilt Brain Inst, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
   [Sutcliffe, James S.] Vanderbilt Univ, Vanderbilt Brain Inst, Dept Psychiat, Nashville, TN 37232 USA.
   [Devlin, Bernie] Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA 15260 USA.
RP Daly, MJ (reprint author), Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA.
EM mjdaly@atgu.mgh.harvard.edu
RI Altshuler, David/A-4476-2009; Sutcliffe, James/C-1348-2012; Liu,
   Li/G-1897-2015
OI Altshuler, David/0000-0002-7250-4107; Sutcliffe,
   James/0000-0001-5200-6007; 
FU National Institute of Mental Health (NIMH) repository [U24MH068457];
   Autism Genetic Resource Exchange (AGRE) Consortium [1U24MH081810];
   Autism Speaks; Simons Foundation; Autism Consortium; NIH [R01MH089208,
   R01MH089025, R01MH089004, R01MH089175, R01MH089482, P50HD055751,
   R01MH057881, R01MH061009]; Lung GO Sequencing Project [HL-102923]; WHI
   Sequencing Project [HL-102924]; Broad GO Sequencing Project [HL-102925];
   Seattle GO Sequencing Project [HL-102926]; Heart GO Sequencing Project
   [HL-103010];  [U54 HG003273];  [U54 HG003067]
FX We gratefully acknowledge the following resources and families who
   contributed to them: the National Institute of Mental Health (NIMH)
   repository (U24MH068457); Autism Genetic Resource Exchange (AGRE)
   Consortium, a program of Autism Speaks (1U24MH081810 to Clara M.
   Lajonchere); The Autism Simplex Collection (TASC) (grant from Autism
   Speaks); Simons Foundation Autism Research Initiative (SFARI) Simplex
   Collection (grant from the Simons Foundation); The Autism Consortium
   (grant from the Autism Consortium). For full citation of resources,
   please see Supplemental Information. This work was directly supported by
   NIH grants R01MH089208 (M.J.D.), R01MH089025 (J.D.B.), R01MH089004
   (G.D.S.), R01MH089175 (R.A.G.), and R01MH089482 (J.S.S.) and supported
   in part by NIH grants P50HD055751 (E.H.C.), R01MH057881 (S.D.), and
   R01MH061009 (J.S.S.). We acknowledge partial support from U54 HG003273
   (R.A.G.) and U54 HG003067 (E. Lander). We thank Thomas Lehner (NIMH),
   Adam Felsenfeld (NHGRI), and Patrick Bender (NIMH) for their support and
   contribution to the project. E.B., J.D.B., S.D., M.J.D., R.A.G., K.R.,
   A.S., G.D.S., and J.S.S. are lead investigators in the ARRA Autism
   Sequencing Collaboration (AASC). We would also like to thank the NHLBI
   GO Exome Sequencing Project and its ongoing studies that produced and
   provided exome variant calls for comparison: the Lung GO Sequencing
   Project (HL-102923), the WHI Sequencing Project (HL-102924), the Broad
   GO Sequencing Project (HL-102925), the Seattle GO Sequencing Project
   (HL-102926), and the Heart GO Sequencing Project (HL-103010).
CR [Anonymous], 2012, MMWR SURVEILL SUMM, V61, P1
   Casey JP, 2012, HUM GENET, V131, P565, DOI 10.1007/s00439-011-1094-6
   Celestino-Soper PBS, 2011, HUM MOL GENET, V20, P4360, DOI 10.1093/hmg/ddr363
   Celestino-Soper PBS, 2012, P NATL ACAD SCI USA, V109, P7974, DOI 10.1073/pnas.1120210109
   Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
   Challis D, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-8
   Constantino J.N., 2012, MOL PSYCHIAT
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Fromer M, 2012, AM J HUM GENET, V91, P597, DOI 10.1016/j.ajhg.2012.08.005
   Girirajan S, 2012, NEW ENGL J MED, V367, P1321, DOI 10.1056/NEJMoa1200395
   Gorlov IP, 2008, AM J HUM GENET, V82, P100, DOI 10.1016/j.ajhg.2007.09.006
   Gottipati S, 2011, NAT GENET, V43, P741, DOI 10.1038/ng.877
   Homer N, 2009, PLOS ONE, V4, pA95, DOI 10.1371/journal.pone.0007767
   Ishikawa T, 2012, NEUROSCIENCE, V214, P181, DOI 10.1016/j.neuroscience.2012.04.030
   Johansson M, 2010, RES DEV DISABIL, V31, P9, DOI 10.1016/j.ridd.2009.07.011
   JORDE LB, 1991, AM J HUM GENET, V49, P932
   Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   lossifov I., 2012, NEURON, V74, P285
   MacArthur DG, 2012, SCIENCE, V335, P823, DOI 10.1126/science.1215040
   McKenna A, 2010, GENOME RES, V20, P1297, DOI 10.1101/gr.107524.110
   McLaren W, 2010, BIOINFORMATICS, V26, P2069, DOI 10.1093/bioinformatics/btq330
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   Nava C, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.102
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Renieri A, 2009, BRAIN DEV-JPN, V31, P208, DOI 10.1016/j.braindev.2008.04.007
   RITVO ER, 1985, AM J PSYCHIAT, V142, P187
   Roll P, 2010, HUM MOL GENET, V19, P4848, DOI 10.1093/hmg/ddq415
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Speevak MD, 2011, AM J MED GENET B, V156B, P484, DOI 10.1002/ajmg.b.31186
   Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Yan D, 2010, J HUM GENET, V55, P327, DOI 10.1038/jhg.2010.29
   Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
   Zhang B, 2005, NUCLEIC ACIDS RES, V33, pW741, DOI 10.1093/nar/gki475
   Zweier C, 2009, AM J HUM GENET, V85, P655, DOI 10.1016/j.ajhg.2009.10.004
NR 42
TC 65
Z9 69
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD JAN 23
PY 2013
VL 77
IS 2
BP 235
EP 242
DI 10.1016/j.neuron.2012.12.029
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA 079VD
UT WOS:000314199400006
PM 23352160
ER

PT J
AU Yu, TW
   Chahrour, MH
   Coulter, ME
   Jiralerspong, S
   Okamura-Ikeda, K
   Ataman, B
   Schmitz-Abe, K
   Harmin, DA
   Adli, M
   Malik, AN
   D'Gama, AM
   Lim, ET
   Sanders, SJ
   Mochida, GH
   Partlow, JN
   Sunu, CM
   Felie, JM
   Rodriguez, J
   Nasir, RH
   Ware, J
   Joseph, RM
   Hill, RS
   Kwan, BY
   Al-Saffar, M
   Mukaddes, NM
   Hashmi, A
   Balkhy, S
   Gascon, GG
   Hisama, FM
   LeClair, E
   Poduri, A
   Oner, O
   Al-Saad, S
   Al-Awadi, SA
   Bastaki, L
   Ben-Omran, T
   Teebi, AS
   Al-Gazali, L
   Eapen, V
   Stevens, CR
   Rappaport, L
   Gabriel, SB
   Markianos, K
   State, MW
   Greenberg, ME
   Taniguchi, H
   Braverman, NE
   Morrow, EM
   Walsh, CA
AF Yu, Timothy W.
   Chahrour, Maria H.
   Coulter, Michael E.
   Jiralerspong, Sarn
   Okamura-Ikeda, Kazuko
   Ataman, Bulent
   Schmitz-Abe, Klaus
   Harmin, David A.
   Adli, Mazhar
   Malik, Athar N.
   D'Gama, Alissa M.
   Lim, Elaine T.
   Sanders, Stephan J.
   Mochida, Ganesh H.
   Partlow, Jennifer N.
   Sunu, Christine M.
   Felie, Jillian M.
   Rodriguez, Jacqueline
   Nasir, Ramzi H.
   Ware, Janice
   Joseph, Robert M.
   Hill, R. Sean
   Kwan, Benjamin Y.
   Al-Saffar, Muna
   Mukaddes, Nahit M.
   Hashmi, Asif
   Balkhy, Soher
   Gascon, Generoso G.
   Hisama, Fuki M.
   LeClair, Elaine
   Poduri, Annapurna
   Oner, Ozgur
   Al-Saad, Samira
   Al-Awadi, Sadika A.
   Bastaki, Laila
   Ben-Omran, Tawfeg
   Teebi, Ahmad S.
   Al-Gazali, Lihadh
   Eapen, Valsamma
   Stevens, Christine R.
   Rappaport, Leonard
   Gabriel, Stacey B.
   Markianos, Kyriacos
   State, Matthew W.
   Greenberg, Michael E.
   Taniguchi, Hisaaki
   Braverman, Nancy E.
   Morrow, Eric M.
   Walsh, Christopher A.
TI Using Whole-Exome Sequencing to Identify Inherited Causes of Autism
SO NEURON
LA English
DT Article
ID RHIZOMELIC CHONDRODYSPLASIA PUNCTATA; DE-NOVO MUTATIONS; GLYCINE
   CLEAVAGE SYSTEM; COPY-NUMBER VARIATION; COHEN-SYNDROME; SPECTRUM
   DISORDERS; NONKETOTIC HYPERGLYCINEMIA; CLINICAL VARIABILITY;
   CRYSTAL-STRUCTURE; PTS2 RECEPTOR
AB Despite significant heritability of autism spectrum disorders (ASDs), their extreme genetic heterogeneity has proven challenging for gene discovery. Studies of primarily simplex families have implicated de novo copy number changes and point mutations, but are not optimally designed to identify inherited risk alleles. We apply whole-exome sequencing (WES) to ASD families enriched for inherited causes due to consanguinity and find familial ASD associated with biallelic mutations in disease genes (AMT, PEX7, SYNE1, VPS13B, PAH, and POMGNT1). At least some of these genes show biallelic mutations in nonconsanguineous families as well. These mutations are often only partially disabling or present atypically, with patients lacking diagnostic features of the Mendelian disorders with which these genes are classically associated. Our study shows the utility of WES for identifying specific genetic conditions not clinically suspected and the importance of partial loss of gene function in ASDs.
C1 [Yu, Timothy W.; Chahrour, Maria H.; Coulter, Michael E.; Schmitz-Abe, Klaus; Mochida, Ganesh H.; Partlow, Jennifer N.; Sunu, Christine M.; Felie, Jillian M.; Rodriguez, Jacqueline; Hill, R. Sean; Al-Saffar, Muna; Markianos, Kyriacos; Walsh, Christopher A.] Boston Childrens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA.
   [Yu, Timothy W.; Chahrour, Maria H.; Coulter, Michael E.; Schmitz-Abe, Klaus; Mochida, Ganesh H.; Partlow, Jennifer N.; Sunu, Christine M.; Felie, Jillian M.; Rodriguez, Jacqueline; Hill, R. Sean; Al-Saffar, Muna; Markianos, Kyriacos; Walsh, Christopher A.] Boston Childrens Hosp, Manton Ctr Orphan Dis Res, Boston, MA 02115 USA.
   [Yu, Timothy W.; Chahrour, Maria H.; Coulter, Michael E.; Mochida, Ganesh H.; Partlow, Jennifer N.; Sunu, Christine M.; Felie, Jillian M.; Rodriguez, Jacqueline; Hill, R. Sean; Walsh, Christopher A.] Boston Childrens Hosp, Howard Hughes Med Inst, Boston, MA 02115 USA.
   [Yu, Timothy W.; Chahrour, Maria H.; Joseph, Robert M.; Rappaport, Leonard; Morrow, Eric M.; Walsh, Christopher A.] Autism Consortium, Boston, MA 02115 USA.
   [Yu, Timothy W.; Chahrour, Maria H.; Coulter, Michael E.; Schmitz-Abe, Klaus; D'Gama, Alissa M.; Mochida, Ganesh H.; Nasir, Ramzi H.; Ware, Janice; Hill, R. Sean; LeClair, Elaine; Poduri, Annapurna; Rappaport, Leonard; Markianos, Kyriacos; Walsh, Christopher A.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
   [Yu, Timothy W.; Mochida, Ganesh H.; Gascon, Generoso G.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA.
   [Yu, Timothy W.; Chahrour, Maria H.; Stevens, Christine R.; Gabriel, Stacey B.; Walsh, Christopher A.] MIT, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.
   [Yu, Timothy W.; Chahrour, Maria H.; Stevens, Christine R.; Gabriel, Stacey B.; Walsh, Christopher A.] Harvard Univ, Cambridge, MA 02142 USA.
   [Jiralerspong, Sarn; Braverman, Nancy E.] McGill Univ, Montreal Childrens Hosp, Res Inst, Dept Human Genet & Pediat, Montreal, PQ H3H 1P3, Canada.
   [Okamura-Ikeda, Kazuko; Taniguchi, Hisaaki] Univ Tokushima, Inst Enzyme Res, Tokushima 7708501, Japan.
   [Ataman, Bulent; Harmin, David A.; Malik, Athar N.; Greenberg, Michael E.] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA.
   [Adli, Mazhar] Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA.
   [Lim, Elaine T.] Massachusetts Gen Hosp, Ctr Human Genet Res, Analyt & Translat Genet Unit, Boston, MA 02114 USA.
   [Sanders, Stephan J.; State, Matthew W.] Yale Univ, Sch Med, Dept Genet, Ctr Human Genet & Genom, New Haven, CT 06510 USA.
   [Sanders, Stephan J.; State, Matthew W.] Yale Univ, Sch Med, Program Neurogenet, New Haven, CT 06510 USA.
   [Nasir, Ramzi H.; Ware, Janice; LeClair, Elaine; Rappaport, Leonard] Boston Childrens Hosp, Div Dev Med, Boston, MA 02115 USA.
   [Joseph, Robert M.] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA.
   [Kwan, Benjamin Y.] Univ Western Ontario, Schulich Sch Med & Dent, London, ON N6A 5C1, Canada.
   [Al-Saffar, Muna; Al-Gazali, Lihadh] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Paediat, Al Ain, U Arab Emirates.
   [Mukaddes, Nahit M.; Gascon, Generoso G.] Istanbul Univ, Dept Child Psychiat, Istanbul Fac Med, TR-34452 Istanbul, Turkey.
   [Hashmi, Asif] Armed Forces Hosp, King Abdulaziz Naval Base, Jubail Ind City 31951, Saudi Arabia.
   [Balkhy, Soher] King Faisal Specialist Hosp & Res Ctr, Dept Neurosci & Pediat, Jeddah 21499, Saudi Arabia.
   [Gascon, Generoso G.] Brown Univ, Sch Med, Providence, RI 02912 USA.
   [Hisama, Fuki M.] Univ Washington, Dept Med, Div Med Genet, Seattle, WA 98195 USA.
   [Poduri, Annapurna] Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA.
   [Oner, Ozgur] Dr Sami Ulus Childrens Hosp, Dept Child & Adolescent Psychiat, TR-06090 Ankara, Turkey.
   [Al-Saad, Samira] Kuwait Ctr Autism, Kuwait 73455, Kuwait.
   [Al-Awadi, Sadika A.; Bastaki, Laila] Kuwait Med Genet Ctr, Kuwait 72458, Kuwait.
   [Ben-Omran, Tawfeg; Teebi, Ahmad S.] Hamad Med Corp, Dept Pediat, Sect Clin & Metab Genet, Doha, Qatar.
   [Ben-Omran, Tawfeg; Teebi, Ahmad S.] Weill Cornell Med Coll, Dept Pediat, New York, NY 10065 USA.
   [Ben-Omran, Tawfeg; Teebi, Ahmad S.] Weill Cornell Med Coll, Dept Med Genet, New York, NY 10065 USA.
   [Ben-Omran, Tawfeg; Teebi, Ahmad S.] Weill Cornell Med Coll, Dept Pediat, Doha, Qatar.
   [Ben-Omran, Tawfeg; Teebi, Ahmad S.] Weill Cornell Med Coll, Dept Med Genet, Doha, Qatar.
   [Eapen, Valsamma] Univ New S Wales, Acad Unit Child Psychiat SW Sydney AUCS, Sydney, NSW 2170, Australia.
   [Morrow, Eric M.] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA.
   [Morrow, Eric M.] Brown Univ, Dept Psychiat & Human Behav, Providence, RI 02912 USA.
RP Yu, TW (reprint author), Boston Childrens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA.
EM timothy.yu@childrens.harvard.edu;
   christopher.walsh@childrens.harvard.edu
RI Morrow, Eric/J-2767-2013; Joseph, Roy/D-8530-2015
FU National Institute of Mental Health (NIMH); National Institute of Health
   (NIH) [T32 NS007484-08, T32 N5007473-12]; Clinical Investigator Training
   Program (CITP) at Harvard-MIT Health Sciences and Technology; Beth
   Israel Deaconess Medical Center; Pfizer, Inc.; Merck and Company, Inc.;
   Nancy Lurie Marks Junior Faculty MeRIT Fellowship; NARSAD; National
   Institutes of Neurological Disease and Stroke [K23NS069784]; National
   Institute of General Medical Sciences [T32GM07753]; National Institute
   of Mental Health [RO1 MH083565, 1RC2MH089952]; NIH [RO1 N5048276]; NIMH
   [1K23MH080954-01]; Dubai Harvard Foundation for Medical Research; Nancy
   Lurie Marks Foundation; Simons Foundation; Autism Consortium; Manton
   Center for Orphan Disease Research; ARRA Grand Opportunities
   [1RC2MH089952]
FX We are grateful to Ed Gilmore, Chiara Manzini, Jenny Yang, and Mark Daly
   for stimulating discussions and helpful comments on the manuscript and
   Thomas Lehner for support from the National Institute of Mental Health
   (NIMH). We are also grateful for the participation of the many families
   that enrolled in our studies as well as for the collaborative support of
   the Kuwait Center for Autism and the Dubai Autism Center. T.W.Y. was
   supported by a National Institute of Health (NIH) T32 grant (T32
   NS007484-08), the Clinical Investigator Training Program (CITP) at
   Harvard-MIT Health Sciences and Technology and Beth Israel Deaconess
   Medical Center in collaboration with Pfizer, Inc. and Merck and Company,
   Inc., and the Nancy Lurie Marks Junior Faculty MeRIT Fellowship. M.H.C.
   was supported by a NIH T32 grant (T32 N5007473-12). G.H.M. was supported
   by the Young Investigator Award of NARSAD as a NARSAD Lieber
   Investigator. A.P. was supported by the National Institutes of
   Neurological Disease and Stroke (K23NS069784). A.M.D. was supported by
   the National Institute of General Medical Sciences (T32GM07753).
   Research was supported by grants from the National Institute of Mental
   Health (RO1 MH083565; 1RC2MH089952) to C.A.W., the NIH to M.E.G. (RO1
   N5048276), the NIMH to E.M.M. (1K23MH080954-01), the Dubai Harvard
   Foundation for Medical Research, the Nancy Lurie Marks Foundation, the
   Simons Foundation, the Autism Consortium, and the Manton Center for
   Orphan Disease Research. Sequencing at the Broad Institute was supported
   by the ARRA Grand Opportunities grant 1RC2MH089952. C.A.W. is an
   Investigator of the Howard Hughes Medical Institute. T.W.Y. identified
   AMT, PEX7, and SYNE1 mutations, helped design AMT and PEX7 functional
   studies, designed and performed exome sequencing analyses for candidate
   genes, contributed to CNV analyses, and wrote the manuscript. M.H.C.
   designed and performed exome sequencing analyses for candidate genes,
   analyzed Sanger validation data and SSC exome data, and wrote the
   manuscript. M.E.C. helped analyze AU-1700 and AU-3500. S.J. designed
   PEX7 functional experiments with N.E.B., and S.J. performed them.
   K.O.-I. designed and performed AMT functional studies and analyzed
   results. B.A. designed and analyzed RNAseq, ChIPseq, and gPOR
   experiments. D.A.H. analyzed RNAseq and qPCR experiments. M.A. performed
   ChIPseq experiments, and A.N.M. analyzed the data. A.M.D. performed RACE
   experiments for SYNE1. K.S.-A. and K.M. designed the CNV analysis, and
   KS.-A. compiled the CNV catalog and identified pathogenic CNVs. E.T.L.
   and S.J.S. helped analyze SSC whole-exome data. G.H.M. performed
   clinical phenotyping of Middle Eastern families as well as detailed
   molecular analyses of AU-8600. J.N.P. organized clinical information and
   patient samples. C.M.S. assisted with exome sequencing analyses and
   performed follow-up Sanger validation. J.M.F. and J.R. performed
   follow-up Sanger validation. R.H.N. performed clinical phenotyping of
   AU-17800. J.W performed clinical phenotyping of AU-17700 and AU-17800.
   R.M.J. performed clinical phenotyping of AU-1600, AU-10000, and
   AU-10200. R.S.H. performed genome-wide linkage studies and homozygosity
   analyses. B.Y.K. assisted with characterization of the AMT mutation.
   MA-S. organized clinical information and patient samples and referred
   AU17700 and AU-17800. N.M.M. referred and clinically characterized
   AU-4200, AU-4400, AU-4900, AU-5700, AU-6100, AU-6200, AU-6300, AU-8600,
   AU11100, AU-11800, AU-11900, AU-12100, AU-12400, AU-14900, AU-15800,
   AU-16700, AU-20700, AU-22500, AU-23400, and AU-24300. A.H.referred and
   characterized AU-3500 and AU-3600. S.B. referred and characterized
   AU-1700. G.G. referred and characterized AU-1700, AU-3100, AU-4100, and
   AU-6000. F.M.H. helped characterize AU-17700 and AU-17800. E.L. and A.P.
   performed clinical phenotyping of AU-1600, AU-10000, and AU10200. 0.0.
   referred and characterized AU-13100, AU-13400, AU-18000, AU-20300, and
   AU-22000. S.A.-S., S.A.A.-A., and LB. referred and characterized
   AU-1600. S.A.-S. referred and characterized AU-9600. T.B.-0. and A.S.T.
   referred and characterized AU-21100. L.A.-G. and V.E. referred and
   characterized AU-3200. C.R.S. organized and coordinated exome
   sequencing. L.R. evaluated the second compound heterozygous PEX7 family.
   S.B.G. directed exome sequencing. KM. designed the CNV analysis. M.W.S.
   oversaw SSC exome analyses. M.E.G. oversaw SYNE1 RNAseq and qPCR
   experiments. H.T. designed and performed AMT functional experiments.
   N.E.B. designed PEX7 functional experiments, recruited the
   nonconsanguineous family with two sisters affected by PEX7 mutation, and
   contributed to interpretation of PEX7 sequencing data. E.M.M. helped
   characterize AU-1700, performed linkage studies on AU-1600, AU-1700, and
   AU-3500, helped design the exome sequencing experiment, and contributed
   to finding the SYNE1 mutation. C.A.W. directed the overall research and
   wrote the manuscript.
CR Adli M, 2011, NAT PROTOC, V6, P1656, DOI 10.1038/nprot.2011.402
   Applegarth D A, 2004, J Inherit Metab Dis, V27, P417, DOI 10.1023/B:BOLI.0000031222.38328.59
   Applegarth DA, 2001, MOL GENET METAB, V74, P139, DOI 10.1006/mgme.2001.3224
   Attali R, 2009, HUM MOL GENET, V18, P3462, DOI 10.1093/hmg/ddp290
   Baer K., 2009, FRONT MOL NEUROSCI, V2
   Bamshad MJ, 2011, NAT REV GENET, V12, P745, DOI 10.1038/nrg3031
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Braverman N, 2002, HUM MUTAT, V20, P284, DOI 10.1002/humu.10124
   Braverman N, 1997, NAT GENET, V15, P369, DOI 10.1038/ng0497-369
   Casey JP, 2012, HUM GENET, V131, P565, DOI 10.1007/s00439-011-1094-6
   Celestino-Soper PBS, 2012, P NATL ACAD SCI USA, V109, P7974, DOI 10.1073/pnas.1120210109
   Chahrour M, 2007, NEURON, V56, P422, DOI 10.1016/j.neuron.2007.10.001
   Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
   Cottrell JR, 2004, NEURON, V44, P677, DOI 10.1016/S0896-6273(04)00688-9
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Dinopoulos A, 2005, MOL GENET METAB, V86, P61, DOI 10.1016/j.ymgme.2005.07.016
   Douzgou S, 2011, CLIN GENET, V79, P501, DOI 10.1111/j.1399-0004.2011.01669.x
   Ernst J, 2011, NATURE, V473, P43, DOI 10.1038/nature09906
   Godfrey C, 2007, BRAIN, V130, P2725, DOI 10.1093/brain/awm212
   Grady RM, 2005, P NATL ACAD SCI USA, V102, P4359, DOI 10.1073/pnas.0500711102
   Gros-Louis F, 2007, NAT GENET, V39, P80, DOI 10.1038/ng1927
   Hagerman R., 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-12
   Haliloglu G, 2004, Acta Myol, V23, P137
   Hamosh AJM, 2001, METABOLIC MOL BASES, P2065
   Hehr U, 2007, NEUROGENETICS, V8, P279, DOI 10.1007/s10048-007-0096-y
   Heintzman ND, 2009, NATURE, V459, P108, DOI 10.1038/nature07829
   Hennies HC, 2004, AM J HUM GENET, V75, P138, DOI 10.1086/422219
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Keck T, 2009, REV NEUROSCIENCE, V20, P13
   Kolehmainen J, 2004, AM J HUM GENET, V75, P122, DOI 10.1086/422197
   Kou JQ, 2011, ACTA NEUROPATHOL, V122, P271, DOI 10.1007/s00401-011-0836-9
   Kryukov GV, 2007, AM J HUM GENET, V80, P727, DOI 10.1086/513473
   LANDER ES, 1987, SCIENCE, V236, P1567, DOI 10.1126/science.2884728
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
   lossifov I., 2012, NEURON, V74, P285
   Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
   McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
   Mochida GH, 2004, J MED GENET, V41, DOI 10.1136/jmg.2003.014779
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   Motley AM, 1997, NAT GENET, V15, P377, DOI 10.1038/ng0497-377
   Najmabadi H, 2011, NATURE, V478, P57, DOI 10.1038/nature10423
   Okamura-Ikeda K, 2005, J MOL BIOL, V351, P1146, DOI 10.1016/j.jmb.2005.06.056
   Okamura-Ikeda K, 2010, J BIOL CHEM, V285, P18684, DOI 10.1074/jbc.M110.110718
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Schienkiewitz A, 2011, ACTA PAEDIATR, V100, pe28, DOI 10.1111/j.1651-2227.2011.02173.x
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Seifert W, 2011, J BIOL CHEM, V286, P37665, DOI 10.1074/jbc.M111.267971
   Seifert W, 2006, J MED GENET, V43, DOI 10.1136/jmg.2005.039867
   Simpson JG, 2008, BIOCHEM SOC T, V36, P1359, DOI 10.1042/BST0361359
   Sklar P, 2011, NAT GENET, V43, P977, DOI 10.1038/ng.943
   Starr DA, 2002, SCIENCE, V298, P406, DOI 10.1126/science1075119
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   Stitziel NO, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-9-227
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   TSUKAMOTO T, 1994, J BIOL CHEM, V269, P6001
   van Bokhoven H, 2011, ANNU REV GENET, V45, P81, DOI 10.1146/annurev-genet-110410-132512
   Walsh CA, 2010, NEURON, V68, P245, DOI 10.1016/j.neuron.2010.09.042
   Walters RG, 2010, NATURE, V463, P671, DOI 10.1038/nature08727
   Wang K, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq603
   Watson MS, 2006, PEDIATRICS, V117, pS296, DOI DOI 10.1542/PEDS.2005-2633I
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Wiznitzer M, 2004, J CHILD NEUROL, V19, P675
   Woods CG, 2006, AM J HUM GENET, V78, P889, DOI 10.1086/503875
   Zecavati N, 2009, CURR NEUROL NEUROSCI, V9, P129, DOI 10.1007/s11910-009-0021-x
   Zhang QP, 2002, GENOMICS, V80, P473, DOI 10.1006/geno.2002.6859
NR 70
TC 87
Z9 91
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD JAN 23
PY 2013
VL 77
IS 2
BP 259
EP 273
DI 10.1016/j.neuron.2012.11.002
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA 079VD
UT WOS:000314199400009
PM 23352163
ER

PT J
AU Tian, Y
   Li, T
   Sun, MK
   Wan, DD
   Li, Q
   Li, PP
   Zhang, ZC
   Han, JH
   Xie, W
AF Tian, Yao
   Li, Tao
   Sun, Mingkuan
   Wan, Didi
   Li, Qian
   Li, Peipei
   Zhang, Zi Chao
   Han, Junhai
   Xie, Wei
TI Neurexin Regulates Visual Function via Mediating Retinoid Transport to
   Promote Rhodopsin Maturation
SO NEURON
LA English
DT Article
ID SYNAPTIC VESICLE EXOCYTOSIS; ACID-BINDING GLYCOPROTEIN; CYCLOPHILIN
   HOMOLOG NINAA; VITAMIN-A; IN-VIVO; DROSOPHILA-MELANOGASTER; GENETIC
   DISSECTION; CELL-SURVIVAL; PROTEIN; TRANSDUCTION
AB Neurexins are cell adhesion molecules involved in synapse formation and synaptic regulation. Mutations in the neurexin genes are linked to a number of neurodevelopmental disorders such as autism. Here, we show that the Drosophila homolog of alpha-Neurexin is critical for fly visual function. Lack of Neurexin leads to significantly impaired visual function due to reduced rhodopsin levels. We show that the decreased chromophore levels cause deficits in rhodopsin maturation and that Neurexin is required for retinoid transport. Using yeast two-hybrid screening, we identify that Neurexin interacts with apolipoprotein I (ApoL I), a product generated by cleavage of retinoid- and fatty acid-binding glycoprotein (RFABG) that function's in retinoid transport. Finally, we demonstrate that Neurexin is essential for the apolipoproteins level. Our results reveal a role for Neurexin in mediating retinoid transport and subsequent rhodopsin maturation and suggest that Neurexin regulates lipoprotein function.
C1 [Tian, Yao; Li, Tao; Sun, Mingkuan; Wan, Didi; Li, Qian; Li, Peipei; Zhang, Zi Chao; Han, Junhai; Xie, Wei] Southeast Univ, Key Lab Dev Genes & Human Dis, Inst Life Sci, Nanjing 210096, Jiangsu, Peoples R China.
RP Han, JH (reprint author), Southeast Univ, Key Lab Dev Genes & Human Dis, Inst Life Sci, Nanjing 210096, Jiangsu, Peoples R China.
EM junhaihan@seu.edu.cn; wei.xie@seu.edu.cn
RI ZHANG, ZICHAO/C-1764-2014
OI ZHANG, ZICHAO/0000-0003-3402-7757
FU National Natural Science Foundation of China [30930051, 30970663,
   91132706]; National Basic Research Program (973 Program) [2012CB517903];
   New-Century Training Program Foundation for Talent by the State
   Education Commission; Youth Foundation of Southeast University
FX We thank Dr. C.S. Zuker for providing ninaA<SUP>269</SUP> flies,
   anti-INAD antibody, and anti-NINAA antibody; Dr. Hong-sheng Li for
   providing anti-TRP antibody and anti-Arr2 antibody; Dr. Suzanne Eaton
   for providing anti-ApoL I antibody, anti-ApoL II antibody, and
   p[UAS-RFABG] transgenic flies; Bloomington Stock Center for the flies;
   Dr. Zhengping Jia, Dr. Li-Yang Chiang, Dr. Zikai Zhou, and members of
   the Han laboratory for their critical comments on the manuscript. This
   work was supported by the National Natural Science Foundation of China
   (Key program 30930051) and the National Basic Research Program (973
   Program) Grant (2012CB517903) to W.X. and the National Natural Science
   Foundation of China (30970663 and 91132706) and the New-Century Training
   Program Foundation for Talent by the State Education Commission and
   Youth Foundation of Southeast University to J.H.
CR BENZER S, 1967, P NATL ACAD SCI USA, V58, P1112, DOI 10.1073/pnas.58.3.1112
   Biederer T, 2000, J BIOL CHEM, V275, P39803, DOI 10.1074/jbc.C000656200
   Butz S, 1998, CELL, V94, P773, DOI 10.1016/S0092-8674(00)81736-5
   Cao JG, 2011, EMBO J, V30, P3701, DOI 10.1038/emboj.2011.254
   CARLSON A, 1992, BIOCHEMISTRY-US, V31, P9056, DOI 10.1021/bi00152a049
   Chen KY, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011115
   Clandinin TR, 2000, NEURON, V28, P427, DOI 10.1016/S0896-6273(00)00122-7
   COLLEY NJ, 1991, CELL, V67, P255, DOI 10.1016/0092-8674(91)90177-Z
   Corbett BA, 2007, MOL PSYCHIATR, V12, P292, DOI 10.1038/sj.mp.4001943
   Cunningham LL, 1999, EXP EYE RES, V68, P399, DOI 10.1006/exer.1998.0633
   Dean C, 2003, NAT NEUROSCI, V6, P708, DOI 10.1038/nn1074
   DOLPH PJ, 1993, SCIENCE, V260, P1910, DOI 10.1126/science.8316831
   DUNCAN T, 1994, ARCH BIOCHEM BIOPHYS, V312, P158, DOI 10.1006/abbi.1994.1294
   Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017
   Gu G, 2004, J BIOL CHEM, V279, P18608, DOI 10.1074/jbc.M400323200
   Han J, 2007, EMBO J, V26, P4966, DOI 10.1038/sj.emboj.7601929
   Han JH, 2006, CELL, V127, P847, DOI 10.1016/j.cell.2006.09.030
   Hardie RC, 2001, NATURE, V413, P186, DOI 10.1038/35093002
   HARRIS WA, 1976, J PHYSIOL-LONDON, V256, P415
   HARRIS WA, 1977, NATURE, V266, P648, DOI 10.1038/266648a0
   Jin MH, 2009, J NEUROSCI, V29, P1486, DOI 10.1523/JNEUROSCI.3882-08.2009
   JOHNSON EC, 1986, J GEN PHYSIOL, V88, P651, DOI 10.1085/jgp.88.5.651
   Kiefer C, 2002, P NATL ACAD SCI USA, V99, P10581, DOI 10.1073/pnas.162182899
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   Kutty RK, 1996, J BIOL CHEM, V271, P20641
   Li J, 2007, NEURON, V55, P741, DOI 10.1016/j.neuron.2007.08.002
   LUO LQ, 1994, GENE DEV, V8, P1787, DOI 10.1101/gad.8.15.1787
   Missler M, 1998, TRENDS GENET, V14, P20, DOI 10.1016/S0168-9525(97)01324-3
   Missler M, 2003, NATURE, V423, P939, DOI 10.1038/nature01755
   Montell C, 1999, ANNU REV CELL DEV BI, V15, P231, DOI 10.1146/annurev.cellbio.15.1.231
   Mosedale M, 2012, J BIOL CHEM, V287, P6350, DOI 10.1074/jbc.M111.299081
   Mukherjee K, 2008, CELL, V133, P328, DOI 10.1016/j.cell.2008.02.036
   Niemeyer BA, 1996, CELL, V85, P651, DOI 10.1016/S0092-8674(00)81232-5
   OTOUSA JE, 1985, CELL, V40, P839, DOI 10.1016/0092-8674(85)90343-5
   OZAKI K, 1993, NEURON, V10, P1113, DOI 10.1016/0896-6273(93)90059-Z
   Pacione LR, 2003, ANNU REV NEUROSCI, V26, P657, DOI 10.1146/annurev.neuro.26.041002.131416
   Pak W.L., 1979, P67
   Palczewski K, 1997, CURR OPIN NEUROBIOL, V7, P500, DOI 10.1016/S0959-4388(97)80029-3
   Panakova D, 2005, NATURE, V435, P58, DOI 10.1038/nature03504
   Paraoanu LE, 2006, NEUROSCI LETT, V395, P114, DOI 10.1016/j.neulet.2005.10.076
   PUSCHEL AW, 1995, J NEUROSCI, V15, P2849
   Rosenbaum EE, 2006, NEURON, V49, P229, DOI 10.1016/j.neuron.2005.12.011
   Rowen L, 2002, GENOMICS, V79, P587, DOI 10.1006/geno.2002.6734
   Sarfare S, 2005, J BIOL CHEM, V280, P11895, DOI 10.1074/jbc.M412236200
   Satoh AK, 2005, CURR BIOL, V15, P1722, DOI 10.1016/j.cub.2005.08.064
   Scheiffele P, 2003, ANNU REV NEUROSCI, V26, P485, DOI 10.1146/annurev.neuro.26.043002.094940
   Scheiffele P, 2000, CELL, V101, P657, DOI 10.1016/S0092-8674(00)80877-6
   SCOTT K, 1995, NEURON, V15, P919, DOI 10.1016/0896-6273(95)90182-5
   SHIEH BH, 1989, NATURE, V338, P67, DOI 10.1038/338067a0
   Shim K, 1997, EXP EYE RES, V65, P717, DOI 10.1006/exer.1997.0383
   STAMNES MA, 1991, CELL, V65, P219, DOI 10.1016/0092-8674(91)90156-S
   Stephenson R S, 1983, Symp Soc Exp Biol, V36, P477
   SUNG CH, 1994, J NEUROSCI, V14, P5818
   USHKARYOV YA, 1992, SCIENCE, V257, P50, DOI 10.1126/science.1621094
   Verstreken P, 2003, NEURON, V40, P733, DOI 10.1016/S0896-6273(03)00644-5
   von Lintig J, 2001, P NATL ACAD SCI USA, V98, P1130, DOI 10.1073/pnas.031576398
   von Lintig J, 2000, J BIOL CHEM, V275, P11915, DOI 10.1074/jbc.275.16.11915
   Voolstra O, 2010, J BIOL CHEM, V285, P2130, DOI 10.1074/jbc.M109.056101
   WALD G, 1968, NATURE, V219, P800, DOI 10.1038/219800a0
   Wang T, 2005, J NEUROSCI, V25, P5187, DOI 10.1523/JNEUROSCI.0995-05.2005
   Wang T, 2007, PFLUG ARCH EUR J PHY, V454, P821, DOI 10.1007/s00424-007-0251-1
   Wang T, 2007, J CELL BIOL, V177, P305, DOI 10.1083/jcb.200610081
   Wiest MM, 2009, PROSTAG LEUKOTR ESS, V80, P221, DOI 10.1016/j.plefa.2009.01.007
   Zahir FR, 2008, J MED GENET, V45, P239, DOI 10.1136/jmg.2007.054437
   Zeng XK, 2007, FEBS LETT, V581, P2509, DOI 10.1016/j.febslet.2007.04.068
   Zhang C, 2010, NEURON, V66, P403, DOI 10.1016/j.neuron.2010.04.008
   ZUKER CS, 1985, CELL, V40, P851, DOI 10.1016/0092-8674(85)90344-7
NR 67
TC 3
Z9 4
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
J9 NEURON
JI Neuron
PD JAN 23
PY 2013
VL 77
IS 2
BP 311
EP 322
DI 10.1016/j.neuron.2012.11.012
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 079VD
UT WOS:000314199400013
PM 23352167
ER

PT J
AU Sturm, V
   Fricke, O
   Buhrle, CP
   Lenartz, D
   Maarouf, M
   Treuer, H
   Mai, JK
   Lehmkuhl, G
AF Sturm, Volker
   Fricke, Oliver
   Buehrle, Christian P.
   Lenartz, Doris
   Maarouf, Mohammad
   Treuer, Harald
   Mai, Juergen K.
   Lehmkuhl, Gerd
TI DBS in the basolateral amygdala improves symptoms of autism and related
   self-injurious behavior: a case report and hypothesis on the
   pathogenesis of the disorder
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE autism; self-injurious behavior; amygdala; deep brain stimulation
ID SUBTHALAMIC NUCLEUS STIMULATION; TEMPORAL-LOBE EPILEPSY;
   PARKINSONS-DISEASE; PROJECTION NEURONS; EMOTION; INHIBITION; RELEVANCE;
   RESPONSES; BRAIN; MODEL
AB We treated a 13-year-old boy for life-threatening self-injurious behavior (SIB) and severe Kanner's autism with deep brain stimulation (DBS) in the amygdaloid complex as well as in the supra-amygdaloid projection system. Two DBS-electrodes were placed in both structures of each hemisphere. The stimulation contacts targeted the paralaminar, the basolateral (BL), the central amygdala as well as the supra-amygdaloid projection system. DBS was applied to each of these structures, but only stimulation of the BL part proved effective in improving SIB and core symptoms of the autism spectrum in the emotional, social, and even cognitive domains over a follow up of now 24 months. These results, which have been gained for the first time in a patient, support hypotheses, according to which the amygdala may be pivotal in the pathogeneses of autism and point to the special relevance of the BL part.
C1 [Sturm, Volker; Buehrle, Christian P.; Lenartz, Doris; Maarouf, Mohammad; Treuer, Harald] Univ Cologne, Dept Stereotact & Funct Neurosurg, D-50931 Cologne, Germany.
   [Fricke, Oliver; Lehmkuhl, Gerd] Univ Cologne, Dept Child & Adolescent Psychiat, D-50931 Cologne, Germany.
   [Mai, Juergen K.] Univ Dusseldorf, Dept Neuroanat, D-40225 Dusseldorf, Germany.
RP Sturm, V (reprint author), Univ Hosp Cologne, Dept Stereotact & Funct Neurosurg, Kerpener Str 62, D-50937 Cologne, Germany.
EM volker.sturm@uk-koeln.de
FU Medtronic Inc.
FX Volker Sturm is co-founder and shareholder in a start-up company (ANM
   GmbH, Cologne) aiming at the development and production of innovative
   Neurostimulators. He was supported by Medtronic Inc., with financial
   support of visits to some congresses. Medtronic Inc., also supported
   clinical DBS studies by providing impulse generators and DB Selectrodes.
   The other authors declare that the research was conducted in the absence
   of any commercial or financial relationships that could be construed as
   a potential conflict of interest.
CR Akert K., 1961, ELECTRICAL STIMULATI, P288
   ALHEID GF, 1988, NEUROSCIENCE, V27, P1, DOI 10.1016/0306-4522(88)90217-5
   Amaral DG, 2003, GENES BRAIN BEHAV, V2, P295, DOI 10.1034/j.1601-183X.2003.00043.x
   Bachevalier J., 2006, AMYGDALA, P509
   BACHEVALIER J, 1994, NEUROPSYCHOLOGIA, V32, P627, DOI 10.1016/0028-3932(94)90025-6
   BAIRD H W 3rd, 1960, Confin Neurol, V20, P26
   Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
   Benabid AL, 2001, J NEUROL S3, V248, pIII37, DOI 10.1007/PL00007825
   BENABID AL, 1994, STEREOT FUNCT NEUROS, V62, P76, DOI 10.1159/000098600
   Benabid AL, 2009, LANCET NEUROL, V8, P67, DOI 10.1016/S1474-4422(08)70291-6
   BORTHWICKDUFFY SA, 1994, J CONSULT CLIN PSYCH, V62, P17, DOI 10.1037//0022-006X.62.1.17
   Brockhaus H, 1938, J PSYCHOL NEUROL, V49, P1
   Constantino JN, 2005, SOCIAL RESPONSIVENES
   Davis M, 2001, MOL PSYCHIATR, V6, P13, DOI 10.1038/sj.mp.4000812
   Derwinska K, 2009, EUR J HUM GENET, V17, P267, DOI 10.1038/ejhg.2008.176
   FALCONER MA, 1964, ARCH NEUROL-CHICAGO, V10, P233
   DE MOLINA A. FERNANDEZ, 1959, JOUR PHYSIOL, V145, P251
   Freese J. L., 2009, HUMAN AMYGDALA, P3
   Guy W, 1976, DHEW PUBL, P218
   Harkin L. A., 1998, SCIENCE, V282, P1504
   Hensch TK, 1998, SCIENCE, V282, P1504, DOI 10.1126/science.282.5393.1504
   Hussman JP, 2001, J AUTISM DEV DISORD, V31, P247, DOI 10.1023/A:1010715619091
   Jamain S, 2002, MOL PSYCHIATR, V7, P302, DOI 10.1038/sj/mp/4000979
   Lang EJ, 1997, J NEUROPHYSIOL, V77, P341
   Lang EJ, 1998, NEUROSCIENCE, V83, P877, DOI 10.1016/S0306-4522(97)00420-X
   LeDoux J, 2003, CELL MOL NEUROBIOL, V23, P727, DOI 10.1023/A:1025048802629
   Le Jeune F, 2010, EUR J NUCL MED MOL I, V37, P1512, DOI 10.1007/s00259-010-1436-y
   Lochel D., 2007, MORPHOLOGISCHE MULTI
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X
   Luczywek E., 1976, ACTA NEUROCHIR SUPP, V23, P221
   Mai J.K., 2008, ATLAS HUMAN BRAIN, V3rd
   Markram K, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00224
   Markram K, 2008, NEUROPSYCHOPHARMACOL, V33, P901, DOI 10.1038/sj.npp.1301453
   McIntyre RS, 2011, J AFFECT DISORDERS, V128, pS1, DOI 10.1016/S0165-0327(10)00742-1
   Mempel E., 1979, 4 M EUR SOC STER FUN
   Morozov A., 2011, J NEUROSCI, V30, P339
   Narabayashi H, 1963, ARCH NEUROL-CHICAGO, V9, P11
   Narabayashi H., 1970, SPECIAL TOPICS STERE, P65
   Narabayashi H., 1979, 4 M EUR SOC STER FUN
   NARABAYA.H, 1966, CONFIN NEUROL, V27, P168
   Nuttin B, 1999, LANCET, V354, P1526, DOI 10.1016/S0140-6736(99)02376-4
   Oya H, 2009, STEREOT FUNCT NEUROS, V87, P219, DOI 10.1159/000225975
   Peron J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009919
   Pessoa L, 2010, NAT REV NEUROSCI, V11, P773, DOI 10.1038/nrn2920
   Phelps EA, 2006, ANNU REV PSYCHOL, V57, P27, DOI 10.1146/annurev.psych.56.091103.070234
   Popescu AT, 2009, NAT NEUROSCI, V12, P801, DOI 10.1038/nn.2305
   RACINE R, 1978, NEUROSURGERY, V3, P234
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Rutter M., 2006, AUTISM DIAGNOSTIC IN
   Sander D, 2003, REV NEUROSCIENCE, V14, P303
   Santos A, 2011, NEUROIMAGE, V54, P3111, DOI 10.1016/j.neuroimage.2010.11.024
   Schroeder S., 2001, MENT RETARD DEV D R, V17, P3
   Schuler V, 2001, NEURON, V31, P47, DOI 10.1016/S0896-6273(01)00345-2
   Schumann C. M., 2006, UNDERSTANDING AUTISM, P227
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   Voges J, 2002, J NEUROSURG, V96, P269, DOI 10.3171/jns.2002.96.2.0269
   Yilmazer-Hanke D.M., 2012, HUMAN NERVOUS SYSTEM, V3rd, P759
   Yilmazer-Hanke DM, 2007, EXP BRAIN RES, V177, P384, DOI 10.1007/s00221-006-0680-7
NR 59
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD JAN 21
PY 2013
VL 6
AR 341
DI 10.3389/fnhum.2012.00341
PG 10
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 079JR
UT WOS:000314166900001
ER

PT J
AU Mathersul, D
   McDonald, S
   Rushby, JA
AF Mathersul, Danielle
   McDonald, Skye
   Rushby, Jacqueline A.
TI Automatic facial responses to affective stimuli in high-functioning
   adults with autism spectrum disorder
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Autism; Asperger's; Affect; EMG; SCR; Evoked cardiac responses
ID TYPICALLY DEVELOPING-CHILDREN; AFFECTIVE STARTLE MODULATION;
   CEREBRAL-BLOOD-FLOW; ORIENTING RESPONSE; ASPERGER-SYNDROME; EMOTION
   RECOGNITION; FACE RECOGNITION; YOUNG-CHILDREN; REFLEX; EXPRESSIONS
AB Individuals with autism spectrum disorder (ASD) demonstrate atypical behavioural responses to affective stimuli, although the underlying mechanisms remain unclear. Investigating automatic responses to these stimuli may help elucidate these mechanisms. 18 high-functioning adults with ASDs and 18 typically developing controls viewed 54 extreme pleasant (erotica), extreme unpleasant (mutilations), and nonsocial neutral images from the International Affective Picture System (IAPS). Two-thirds of images received an acoustic startle probe 3 s post-picture onset. Facial electromyography (EMG) activity (orbicularis, zygomaticus, corrugator), skin conductance (SCR) and cardiac responses were recorded. The adults with ASDs demonstrated typical affective startle modulation and automatic facial EMG responses but atypical autonomic (SCRs and cardiac) responses, suggesting a failure to orient to, or a deliberate effort to disconnect from, socially relevant stimuli (erotica, mutilations). These results have implications for neural systems known to underlie affective processes, including the orbitofrontal cortex and amygdala. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Mathersul, Danielle; McDonald, Skye; Rushby, Jacqueline A.] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
RP Mathersul, D (reprint author), Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
EM dmathersul@psy.unsw.edu.au
RI McDonald, Skye/G-4118-2014
OI McDonald, Skye/0000-0003-0723-6094
FU Australian Postgraduate Award (APA); Australian National Health and
   Medical Research Council (NHMRC) [APP1013796]
FX DM is supported by an Australian Postgraduate Award (APA). JAR is
   supported by an Australian National Health and Medical Research Council
   (NHMRC) Postdoctoral Fellowship (Clinical Training; APP1013796). This
   research was funded by the Australian National Health and Medical
   Research Council (NHMRC). We would like to thank the individuals who
   gave their time to participate in this study, and the clinicians who
   assisted with participant recruitment.
CR Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6
   Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
   Allen NB, 1999, BIOL PSYCHIAT, V46, P542, DOI 10.1016/S0006-3223(99)00025-6
   Alpers GW, 2011, INT J PSYCHOPHYSIOL, V80, P173, DOI 10.1016/j.ijpsycho.2011.01.010
   American Psychiatric Association (APA), 2011, DSM 5 DEV
   Angrilli A, 2008, NEUROPSYCHOLOGIA, V46, P1179, DOI 10.1016/j.neuropsychologia.2007.10.018
   (APA) APA, 2000, DIAGN STAT MAN MENT
   Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014
   Azevedo TM, 2005, PSYCHOPHYSIOLOGY, V42, P255, DOI 10.1111/j.1469-8986.2005.00287.x
   Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Balaban M. T., 1999, STARTLE MODIFICATION, P21, DOI 10.1017/CBO9780511665523.004
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
   Barry RJ, 2008, BIOL PSYCHOL, V77, P304, DOI 10.1016/j.biopsycho.2007.11.002
   BARRY RJ, 1993, INT J PSYCHOPHYSIOL, V15, P39, DOI 10.1016/0167-8760(93)90093-5
   BARRY RJ, 1990, PAVLOVIAN J BIOL SCI, V25, P93
   Barry RJ, 1990, PAVLOVIAN J BIOL SCI, V25, P99
   Beall PM, 2008, J EXP CHILD PSYCHOL, V101, P206, DOI 10.1016/j.jecp.2008.04.004
   Ben Shalom D, 2006, J AUTISM DEV DISORD, V36, P395, DOI 10.1007/s10803-006-0077-2
   Berthoz S, 2005, EUR PSYCHIAT, V20, P291, DOI 10.1016/j.eurpsy.2004.06.013
   Blumenthal TD, 2005, PSYCHOPHYSIOLOGY, V42, P1, DOI 10.1111/j.1469-8986.2005.00271.x
   Bolte S, 2008, J AUTISM DEV DISORD, V38, P776, DOI 10.1007/s10803-007-0443-8
   BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
   Boucher J, 2000, J CHILD PSYCHOL PSYC, V41, P847, DOI 10.1017/S0021963099006149
   Boucher J, 1998, J CHILD PSYCHOL PSYC, V39, P171, DOI 10.1017/S0021963097001820
   Boucsein W., 1992, ELECTRODERMAL ACTIVI
   Bradley MM, 2005, PSYCHOL SCI, V16, P468
   BRADLEY MM, 1990, PSYCHOPHYSIOLOGY, V27, P513, DOI 10.1111/j.1469-8986.1990.tb01966.x
   Bradley MM, 2001, EMOTION, V1, P276, DOI 10.1037//1528-3542.1.3.276
   BRADLEY MM, 1994, J BEHAV THER EXP PSY, V25, P49, DOI 10.1016/0005-7916(94)90063-9
   CACIOPPO JT, 1986, J PERS SOC PSYCHOL, V50, P260, DOI 10.1037//0022-3514.50.2.260
   Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181
   Corona R, 1998, CHILD DEV, V69, P1494, DOI 10.1111/j.1467-8624.1998.tb06172.x
   Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Davis M, 1997, NEUROPSYCHIATRY LIMB, P71
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   DAWSON G, 1990, J ABNORM CHILD PSYCH, V18, P335, DOI 10.1007/BF00916569
   Dawson G, 2002, DEV PSYCHOPATHOL, V14, P581, DOI 10.1017/S0954579402003103
   De Martino B, 2008, J NEUROSCI, V28, P10746, DOI 10.1523/JNEUROSCI.2895-08.2008
   Dichter GS, 2008, J ABNORM PSYCHOL, V117, P1, DOI 10.1037/0021-843X.117.1.1
   Dichter GS, 2007, NEUROIMAGE, V35, P1219, DOI 10.1016/j.neuroimage.2006.12.038
   Dichter GS, 2010, J AUTISM DEV DISORD, V40, P858, DOI 10.1007/s10803-009-0925-y
   Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
   DIMBERG U, 1982, PSYCHOPHYSIOLOGY, V19, P643, DOI 10.1111/j.1469-8986.1982.tb02516.x
   FRIDLUND AJ, 1986, PSYCHOPHYSIOLOGY, V23, P567, DOI 10.1111/j.1469-8986.1986.tb00676.x
   Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
   GRAHAM FK, 1966, PSYCHOL BULL, V65, P305, DOI 10.1037/h0023258
   Happe F, 1996, NEUROREPORT, V8, P197, DOI 10.1097/00001756-199612200-00040
   Hatfield Elaine, 1994, EMOTIONAL CONTAGION
   Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14
   HODES RL, 1985, PSYCHOPHYSIOLOGY, V22, P545, DOI 10.1111/j.1469-8986.1985.tb01649.x
   Hubert BE, 2009, AUTISM, V13, P9, DOI 10.1177/1362361308091649
   Jansen LMC, 2006, J AUTISM DEV DISORD, V36, P891, DOI 10.1007/s10803-006-0124-z
   Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
   Kaviani H, 2004, J AFFECT DISORDERS, V83, P21, DOI 10.1016/j.jad.2004.04.007
   Kawakubo Y, 2007, CLIN NEUROPHYSIOL, V118, P1464, DOI 10.1016/j.clinph.2007.04.015
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Kuhl PK, 2005, DEVELOPMENTAL SCI, V8, pF1, DOI 10.1111/j.1467-7687.2004.00384.x
   Kylliainen A, 2012, J CHILD PSYCHOL PSYC, V53, P790, DOI 10.1111/j.1469-7610.2011.02522.x
   Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
   Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
   LANG PJ, 1990, PSYCHOL REV, V97, P377, DOI 10.1037//0033-295X.97.3.377
   LANG PJ, 1993, PSYCHOPHYSIOLOGY, V30, P261, DOI 10.1111/j.1469-8986.1993.tb03352.x
   LANG PJ, 1995, AM PSYCHOL, V50, P372, DOI 10.1037//0003-066X.50.5.372
   LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
   Loveland KA, 1997, DEV PSYCHOPATHOL, V9, P579
   Magnee MJCM, 2007, J CHILD PSYCHOL PSYC, V48, P1122, DOI 10.1111/j.1469-7610.2007.01779.x
   MALTZMAN I, 1977, J EXP PSYCHOL GEN, V106, P111, DOI 10.1037/0096-3445.106.2.111
   MALTZMAN I, 1984, J ABNORM PSYCHOL, V93, P41, DOI 10.1037/0021-843X.93.1.41
   Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
   McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
   Oberman LM, 2009, DEVELOPMENTAL SCI, V12, P510, DOI 10.1111/j.1467-7687.2008.00796.x
   Ohman A, 2005, PSYCHONEUROENDOCRINO, V30, P953, DOI 10.1016/j.psyneuen.2005.03.019
   Ohnishi T, 2000, BRAIN, V123, P1838, DOI 10.1093/brain/123.9.1838
   ORNITZ EM, 1993, J AUTISM DEV DISORD, V23, P619, DOI 10.1007/BF01046105
   OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   Phillips ML, 2003, BIOL PSYCHIAT, V54, P504, DOI 10.1016/S0006-3223(03)00168-9
   Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
   Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
   Ritvo RA, 2011, J AUTISM DEV DISORD, V41, P1076, DOI 10.1007/s10803-010-1133-5
   Ritvo RA, 2008, J AUTISM DEV DISORD, V38, P213, DOI 10.1007/s10803-007-0380-6
   Rolls E. T., 1999, BRAIN EMOTION
   Rushby JA, 2009, INT J PSYCHOPHYSIOL, V74, P120, DOI 10.1016/j.ijpsycho.2009.08.003
   Rushby JA, 2007, BIOL PSYCHOL, V75, P248, DOI 10.1016/j.biopsycho.2007.03.003
   Samson AC, 2012, EMOTION, V12, P659, DOI 10.1037/a0027975
   Saracino J, 2010, J DEV PHYS DISABIL, V22, P317, DOI 10.1007/s10882-010-9205-1
   Saunders JC, 2006, NEUROPSYCHOLOGY, V20, P224, DOI 10.1037/0894-4105.20.2.224
   Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
   Smith JC, 2005, BIOL PSYCHOL, V69, P247, DOI 10.1016/j.biopsycho.2004.09.001
   SOKOLOV EN, 1990, PAVLOVIAN J BIOL SCI, V25, P142
   Stel M, 2008, J AUTISM DEV DISORD, V38, P1250, DOI 10.1007/s10803-007-0505-y
   TANTAM D, 1989, J CHILD PSYCHOL PSYC, V30, P623, DOI 10.1111/j.1469-7610.1989.tb00274.x
   Tassinary LG, 2000, HDB PSYCHOPHYSIOLOGY, V2, P163
   Turpin G., 1983, ORIENTING HABITUATIO, P1
   Vaughan Van Hecke A., 2009, CHILD DEV, V80, P1118, DOI DOI 10.1111/J.1467-8624.2009.01320.X
   VRANA SR, 1988, J ABNORM PSYCHOL, V97, P487, DOI 10.1037/0021-843X.97.4.487
   Wang AT, 2007, ARCH GEN PSYCHIAT, V64, P698, DOI 10.1001/archpsyc.64.6.698
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Wilbarger JL, 2009, NEUROPSYCHOLOGIA, V47, P1323, DOI 10.1016/j.neuropsychologia.2009.01.025
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 106
TC 5
Z9 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 17
PY 2013
VL 109
BP 14
EP 22
DI 10.1016/j.physbeh.2012.10.008
PG 9
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA 095HH
UT WOS:000315324800003
PM 23142408
ER

PT J
AU Baharnoori, M
   Bhardwaj, SK
   Srivastava, LK
AF Baharnoori, Moogeh
   Bhardwaj, Sanjeev K.
   Srivastava, Lalit K.
TI Effect of Maternal Lipopolysaccharide Administration on the Development
   of Dopaminergic Receptors and Transporter in the Rat Offspring
SO PLOS ONE
LA English
DT Article
ID PRENATAL IMMUNE ACTIVATION; MEDIAL PREFRONTAL CORTEX;
   GAMMA-AMINOBUTYRIC-ACID; WORKING-MEMORY; HIPPOCAMPAL NEUROGENESIS;
   CORTICAL INTERNEURONS; COGNITIVE IMPAIRMENT; BACTERIAL-ENDOTOXIN;
   ANIMAL-MODELS; SCHIZOPHRENIA
AB Epidemiological evidence supports that maternal infection during gestation are notable risk factors for developmental mental illnesses including schizophrenia and autism. In prenatal lipopolysaccharide (LPS) model of immune activation in rats, the offspring exhibit significant impairments in behaviors mediated by central dopamine (DA) system. This study aimed to examine the temporal and regional pattern of postnatal DA development in the male offspring of pregnant Sprague-Dawley rats administered with 100 mu g/kg LPS or saline at gestational days 15/16. Using ligand autoradiography, D1 and D2 dopamine receptors (D1R, D2R) and dopamine transporter (DAT) binding levels were measured in the prefrontal cortex (PFC) and sub cortical regions (dorsal striatum and nucleus accumbens core and shell) at pre pubertal (P35) and post pubertal ages (P60). We found a significant decrease in D2R ligand [H-3] YM-90151-2 binding in the medial PFC (mPFC) in prenatal LPS-treated animals at P35 and P60 compared to respective saline groups. The decrease in D2R levels was not observed in the striatum or accumbens of maternal LPS-treated animals. No significant changes were observed in [H-3] SCH23390 binding to D1R. However, the level of [I-125] RTI-121 binding to DAT was selectively reduced in the nucleus accumbens core and shell at P35 in the prenatal LPS group. Immunohistochemical analysis showed that number of D2R immunopositive cells in infralimbic/prelimbic (IL/PL) part of mPFC was significantly reduced in the LPS group at P60. Prenatal LPS treatment did not significantly affect either the total number of mature neurons or parvalbumin (PV)- immunopositive interneurons in this region. However the number of PV and D2R co-labeled neurons was significantly reduced in the IL/PL subregion of PFC of LPS treated animals. Our data suggests D2R deficit in the PFC and PV interneurons may be relevant to understanding mechanisms of cortical dysfunctions described in prenatal infection animal models as well as schizophrenia.
C1 [Srivastava, Lalit K.] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada.
   Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
RP Srivastava, LK (reprint author), McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
EM lalit.srivastava@mcgill.ca
FU Canadian Institute of Health Research [ELA 80228]
FX This work was supported by team grant from Canadian Institute of Health
   Research # ELA 80228. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
CR Aalto S, 2005, J NEUROSCI, V25, P2471, DOI 10.1523/JNEUROSCI.2097-04.2005
   Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
   Baharnoori M, 2009, SCHIZOPHR RES, V107, P99, DOI 10.1016/j.schres.2008.10.003
   Beaulieu JM, 2011, PHARMACOL REV, V63, P182, DOI 10.1124/pr.110.002642
   Bitanihirwe BKY, 2010, INT J NEUROPSYCHOPH, V13, P981, DOI 10.1017/S1461145710000192
   Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
   Boksa P, 2008, J PSYCHIATR NEUROSCI, V33, P183
   Borrell J, 2002, NEUROPSYCHOPHARMACOL, V26, P204, DOI 10.1016/S0893-133X(01)00360-8
   BOUNDY VA, 1993, MOL PHARMACOL, V43, P666
   Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
   Cui K, 2009, SCHIZOPHR RES, V113, P288, DOI 10.1016/j.schres.2009.05.003
   Dick Danielle M, 2010, Dialogues Clin Neurosci, V12, P7
   Druzin MY, 2000, BEHAV BRAIN RES, V109, P99, DOI 10.1016/S0166-4328(99)00166-7
   Ducharme G, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029754
   Ernst M, 1997, LANCET, V350, P638, DOI 10.1016/S0140-6736(05)63326-0
   Fatemi SH, 2008, SCHIZOPHR RES, V99, P56, DOI 10.1016/j.schres.2007.11.018
   Flores G, 1998, BRAIN RES, V814, P34, DOI 10.1016/S0006-8993(98)01011-7
   Flores G, 1996, J NEUROSCI, V16, P7366
   Fortier ME, 2004, J PSYCHIAT RES, V38, P335, DOI 10.1016/j.jpsychires.2003.10.001
   Fortier ME, 2007, BEHAV BRAIN RES, V181, P270, DOI 10.1016/j.bbr.2007.04.016
   GOLDMANRAKIC PS, 1995, NEURON, V14, P477, DOI 10.1016/0896-6273(95)90304-6
   Guillin O, 2007, INT REV NEUROBIOL, V78, P1, DOI 10.1016/S0074-7742(06)78001-1
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hashimoto T, 2003, J NEUROSCI, V23, P6315
   Howard MW, 2003, CEREB CORTEX, V13, P1369, DOI 10.1093/cercor/bhg084
   Leviel V, 2011, J NEUROCHEM, V118, P475, DOI 10.1111/j.1471-4159.2011.07335.x
   Lewis DA, 2005, NAT REV NEUROSCI, V6, P312, DOI 10.1038/nrn1648
   Lewis DA, 2006, ARCH NEUROL-CHICAGO, V63, P1372, DOI 10.1001/archneur.63.10.1372
   Marin O, 2012, NAT REV NEUROSCI, V13, P107, DOI 10.1038/nrn3155
   Mendez P, 2011, NEURAL PLAST, DOI 10.1155/2011/976856
   Mengual E, 2002, SYNAPSE, V43, P151, DOI 10.1002/syn.10033
   Meyer U, 2008, NEUROPSYCHOPHARMACOL, V33, P441, DOI 10.1038/sj.npp.1301413
   Meyer U, 2008, BRAIN BEHAV IMMUN, V22, P469, DOI 10.1016/j.bbi.2007.09.012
   Meyer U, 2008, NEUROSCIENCE, V154, P701, DOI 10.1016/j.neuroscience.2008.04.031
   Meyer U, 2009, NEUROSCI BIOBEHAV R, V33, P1061, DOI 10.1016/j.neubiorev.2009.05.001
   Muly EC, 1998, J NEUROSCI, V18, P10553
   Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
   Nouel D, 2012, EUR NEUROPSYCHOPHARM, V22, P300, DOI 10.1016/j.euroneuro.2011.08.001
   O'Donnell P, 2010, NEUROTOX RES, V18, P306, DOI 10.1007/s12640-010-9157-3
   Ozawa K, 2006, BIOL PSYCHIAT, V59, P546, DOI 10.1016/j.biopsych.2005.07.031
   Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
   Paxinos G, 2007, RAT BRAIN STEREOTAXI, V6th
   Piontkewitz Y, 2012, BRAIN BEHAV IMMUN, V26, P353, DOI 10.1016/j.bbi.2011.11.004
   Riley B, 2011, SCHIZOPHRENIA, P245
   Romero E, 2010, MOL PSYCHIATR, V15, P372, DOI 10.1038/mp.2008.44
   Santana N, 2009, CEREB CORTEX, V19, P849, DOI 10.1093/cercor/bhn134
   SEEMAN P, 1987, SYNAPSE, V1, P133, DOI 10.1002/syn.890010203
   Sesack SR, 1998, J NEUROSCI, V18, P2697
   Sorensen HJ, 2009, SCHIZOPHRENIA BULL, V35, P631, DOI 10.1093/schbul/sbn121
   Tseng KY, 2008, J NEUROSCI, V28, P12691, DOI 10.1523/JNEUROSCI.4166-08.2008
   Tseng KY, 2007, CEREB CORTEX, V17, P1235, DOI 10.1093/cercor/bhl034
   van Os J, 2010, NATURE, V468, P203, DOI 10.1038/nature09563
   VINCENT SL, 1993, J NEUROSCI, V13, P2551
   Volk DW, 2000, ARCH GEN PSYCHIAT, V57, P237, DOI 10.1001/archpsyc.57.3.237
   Vuillermot S, 2010, J NEUROSCI, V30, P1270, DOI 10.1523/JNEUROSCI.5408-09.2010
   Zuckerman L, 2005, J PSYCHIAT RES, V39, P311, DOI 10.1016/j.jpsychires.2004.08.008
NR 56
TC 8
Z9 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 17
PY 2013
VL 8
IS 1
AR e54439
DI 10.1371/journal.pone.0054439
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 073JI
UT WOS:000313738900068
PM 23349891
ER

PT J
AU Wang, LF
   Li, J
   Ruan, YY
   Lu, TL
   Liu, CX
   Jia, MX
   Yue, WH
   Liu, J
   Bourgeron, T
   Zhang, D
AF Wang, Lifang
   Li, Jun
   Ruan, Yanyan
   Lu, Tianlan
   Liu, Chenxing
   Jia, Meixiang
   Yue, Weihua
   Liu, Jing
   Bourgeron, Thomas
   Zhang, Dai
TI Sequencing ASMT Identifies Rare Mutations in Chinese Han Patients with
   Autism
SO PLOS ONE
LA English
DT Article
ID DE-NOVO MUTATIONS; SPECTRUM DISORDERS; MELATONIN SYNTHESIS; PROTEIN
   FUNCTION; MOOD DISORDERS; GENE; PATHWAY; ASSOCIATION; CHILDREN; INSOMNIA
AB Melatonin is involved in the regulation of circadian and seasonal rhythms and immune function. Prior research reported low melatonin levels in autism spectrum disorders (ASD). ASMT located in pseudo-autosomal region 1 encodes the last enzyme of the melatonin biosynthesis pathway. A previous study reported an association between ASD and single nucleotide polymorphisms (SNPs) rs4446909 and rs5989681 located in the promoter of ASMT. Furthermore, rare deleterious mutations were identified in a subset of patients. To investigate the association between ASMT and autism, we sequenced all ASMT exons and its neighboring region in 398 Chinese Han individuals with autism and 437 healthy controls. Although our study did not detect significant differences of genotypic distribution and allele frequencies of the common SNPs in ASMT between patients with autism and healthy controls, we identified new rare coding mutations of ASMT. Among these rare variants, 4 were exclusively detected in patients with autism including a stop mutation (p.R115W, p.V166I, p.V179G, and p.W257X). These four coding variants were observed in 6 of 398 (1.51%) patients with autism and none in 437 controls (Chi-Square test, Continuity Correction p = 0.032, two-sided). Functional prediction of impact of amino acid showed that p.R115W might affect protein function. These results indicate that ASMT might be a susceptibility gene for autism. Further studies in larger samples are needed to better understand the degree of variation in this gene as well as to understand the biochemical and clinical impacts of ASMT/melatonin deficiency.
C1 [Wang, Lifang; Li, Jun; Ruan, Yanyan; Lu, Tianlan; Liu, Chenxing; Jia, Meixiang; Yue, Weihua; Liu, Jing; Zhang, Dai] Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China.
   [Wang, Lifang; Li, Jun; Ruan, Yanyan; Lu, Tianlan; Liu, Chenxing; Yue, Weihua; Zhang, Dai] Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China.
   [Zhang, Dai] Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China.
   [Bourgeron, Thomas] Inst Pasteur, CNRS, URA Genes Synapses & Cognit 2182, Paris, France.
   [Bourgeron, Thomas] Univ Paris Diderot, Paris, France.
RP Wang, LF (reprint author), Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China.
EM lifangwang@bjmu.edu.cn; daizhang@bjmu.edu.cn
FU National Basic Research Development Program of China (973 program)
   [2010CB833905]; National Natural Science Foundation [30870897,
   81071110]; Beijing Natural Science Foundation [7081005]
FX This work was supported by research grants from the National Basic
   Research Development Program of China (973 program 2010CB833905),
   National Natural Science Foundation (grant number 30870897 and
   81071110), and Beijing Natural Science Foundation (grant number:
   7081005). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
   Agez L, 2009, J PINEAL RES, V46, P95, DOI 10.1111/j.1600-079X.2008.00636.x
   Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Botros HG, 2012, J PINEAL RES
   Cai GQ, 2008, BMC MED GENOMICS, V1, DOI 10.1186/1755-8794-1-50
   Chaste P, 2011, J PINEAL RES, V51, P394, DOI 10.1111/j.1600-079X.2011.00902.x
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Etain B, 2012, HUM MOL GENET, V21, P4030, DOI 10.1093/hmg/dds227
   Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559
   Gabriel SB, 2002, SCIENCE, V296, P2225, DOI 10.1126/science.1069424
   Galecki P, 2010, J PINEAL RES, V48, P311, DOI 10.1111/j.1600-079X.2010.00754.x
   HALLIWELL B, 1992, ANN NEUROL, V32, pS10, DOI 10.1002/ana.410320704
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Jimenez-Jorge S, 2007, J PINEAL RES, V42, P240, DOI 10.1111/j.1600-079X.2006.00411.x
   Jonsson L, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-10
   Kripke Daniel F, 2011, J Circadian Rhythms, V9, P8, DOI 10.1186/1740-3391-9-8
   Kulman G, 2000, NEUROENDOCRINOL LETT, V21, P31
   Kumar P, 2009, NAT PROTOC, V4, P1073, DOI 10.1038/nprot.2009.86
   Kumar PNS, 2007, J CLIN PSYCHIAT, V68, P237
   LAM RW, 1990, PSYCHIAT RES, V33, P129, DOI 10.1016/0165-1781(90)90066-E
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   Maldonado MD, 2007, J PINEAL RES, V42, P1, DOI 10.1111/j.1600-079X.2006.00376.x
   Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
   Matys V, 2006, NUCLEIC ACIDS RES, V34, pD108, DOI 10.1093/nar/gkj143
   McCarthy MI, 2008, NAT REV GENET, V9, P356, DOI 10.1038/nrg2344
   Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Ng PC, 2003, NUCLEIC ACIDS RES, V31, P3812, DOI 10.1093/nar/gkg509
   Nir I, 1995, J AUTISM DEV DISORD, V25, P641, DOI 10.1007/BF02178193
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Pagan C, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-17
   Park HJ, 2011, J MOL NEUROSCI, V45, P304, DOI 10.1007/s12031-011-9522-6
   Perlis ML, 1997, J AFFECT DISORDERS, V42, P209, DOI 10.1016/S0165-0327(96)01411-5
   Rutter M, 2000, J ABNORM CHILD PSYCH, V28, P3, DOI 10.1023/A:1005113900068
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Srinivasan V, 2006, WORLD J BIOL PSYCHIA, V7, P138, DOI 10.1080/15622970600571822
   Srinivasan V, 2008, NEUROIMMUNOMODULAT, V15, P93, DOI 10.1159/000148191
   Taupin Philippe, 2008, Int J Med Sci, V5, P127
   Tennessen JA, 2012, SCIENCE, V337, P64, DOI 10.1126/science.1219240
   Toma C, 2007, MOL PSYCHIATR, V12, P977, DOI 10.1038/sj.mp.4002069
   Tordjman S, 2005, BIOL PSYCHIAT, V57, P134, DOI 10.1016/j.biopsych.2004.11.003
   Veenstra-Vanderweele J, 2003, J AM ACAD CHILD PSY, V42, P116, DOI 10.1097/01.CHI.0000024913.60748.41
   Wingender E, 2008, BRIEF BIOINFORM, V9, P326, DOI 10.1093/bib/bbn016
NR 44
TC 8
Z9 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 17
PY 2013
VL 8
IS 1
AR e53727
DI 10.1371/journal.pone.0053727
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 073JI
UT WOS:000313738900018
PM 23349736
ER

PT J
AU Bangash, MA
   Park, JM
   Melnikova, T
   Wang, DH
   Jeon, SK
   Lee, D
   Syeda, S
   Kim, J
   Kouser, M
   Schwartz, J
   Cui, YY
   Zhao, X
   Speed, HE
   Kee, SE
   Tu, JC
   Hu, JH
   Petralia, RS
   Linden, DJ
   Powell, CM
   Savonenko, A
   Xiao, B
   Worley, PF
AF Bangash, M. Ali
   Park, Joo Min
   Melnikova, Tatiana
   Wang, Dehua
   Jeon, Soo Kyeong
   Lee, Deidre
   Syeda, Sbaa
   Kim, Juno
   Kouser, Mehreen
   Schwartz, Joshua
   Cui, Yiyuan
   Zhao, Xia
   Speed, Haley E.
   Kee, Sara E.
   Tu, Jian Cheng
   Hu, Jia-Hua
   Petralia, Ronald S.
   Linden, David J.
   Powell, Craig M.
   Savonenko, Alena
   Xiao, Bo
   Worley, Paul F.
TI Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model
   of Autism (Retraction of vol 145, pg 758, 2011)
SO CELL
LA English
DT Correction
EM pworley@jhmi.edu
CR Bangash MA, 2011, CELL, V145, P758, DOI 10.1016/j.cell.2011.03.052
NR 1
TC 2
Z9 2
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
J9 CELL
JI Cell
PD JAN 17
PY 2013
VL 152
IS 1-2
BP 367
EP 367
DI 10.1016/j.cell.2012.12.039
PG 1
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 073CA
UT WOS:000313719800032
ER

PT J
AU Ebert, DH
   Greenberg, ME
AF Ebert, Daniel H.
   Greenberg, Michael E.
TI Activity-dependent neuronal signalling and autism spectrum disorder
SO NATURE
LA English
DT Review
ID X MENTAL-RETARDATION; DE-NOVO MUTATIONS; DENDRITIC SPINE MORPHOLOGY;
   LONG-TERM DEPRESSION; FRAGILE-X; MOUSE MODEL; SYNAPTIC PLASTICITY; BDNF
   TRANSCRIPTION; RETT-SYNDROME; FMRP PHOSPHORYLATION
AB Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder.
C1 [Ebert, Daniel H.; Greenberg, Michael E.] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA.
   [Ebert, Daniel H.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA 02114 USA.
RP Greenberg, ME (reprint author), Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA.
EM michael_greenberg@hms.harvard.edu
FU NIH [RO1NS048276, K08MH90306]; Rett Syndrome Research Trust
FX M.E.G. is supported by NIH grant RO1NS048276 and the Rett Syndrome
   Research Trust. D.H.E. is supported by NIH grant K08MH90306.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   BADING H, 1993, SCIENCE, V260, P181, DOI 10.1126/science.8097060
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Barbosa AC, 2008, P NATL ACAD SCI USA, V105, P9391, DOI 10.1073/pnas.0802679105
   Barrett CF, 2008, P NATL ACAD SCI USA, V105, P2157, DOI 10.1073/pnas.0710501105
   Bateup HS, 2011, J NEUROSCI, V31, P8862, DOI 10.1523/JNEUROSCI.1617-11.2011
   Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
   Bhakar AL, 2012, ANNU REV NEUROSCI, V35, P417, DOI 10.1146/annurev-neuro-060909-153138
   Bhat S, 2012, PROG NEUROBIOL, V99, P1, DOI 10.1016/j.pneurobio.2012.06.001
   Bingol B, 2011, NEURON, V69, P22, DOI 10.1016/j.neuron.2010.11.006
   Ceman S, 2003, HUM MOL GENET, V12, P3295, DOI 10.1093/hmg/ddg350
   Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
   Chao HT, 2007, NEURON, V56, P58, DOI 10.1016/j.neuron.2007.08.018
   Chen WG, 2003, SCIENCE, V302, P885, DOI 10.1126/science.1086446
   Choi YB, 2011, NEURON, V70, P468, DOI 10.1016/j.neuron.2011.03.020
   Chubykin AA, 2007, NEURON, V54, P919, DOI 10.1016/j.neuron.2007.05.029
   Cohen S, 2011, NEURON, V72, P72, DOI 10.1016/j.neuron.2011.08.022
   Cohen S, 2008, ANNU REV CELL DEV BI, V24, P183, DOI 10.1146/annurev.cellbio.24.110707.175235
   Dani VS, 2005, P NATL ACAD SCI USA, V102, P12560, DOI 10.1073/pnas.0506071102
   Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013
   Deng JV, 2010, NAT NEUROSCI, V13, P1128, DOI 10.1038/nn.2614
   Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
   Dolmetsch RE, 2001, SCIENCE, V294, P333, DOI 10.1126/science.1063395
   Ehlers MD, 2003, NAT NEUROSCI, V6, P231, DOI 10.1038/nn1013
   Ehninger D, 2008, NAT MED, V14, P843, DOI 10.1038/nm1788
   Etherton MR, 2011, EMBO J, V30, P2908, DOI 10.1038/emboj.2011.182
   Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106
   Flavell SW, 2008, NEURON, V60, P1022, DOI 10.1016/j.neuron.2008.11.029
   Flavell SW, 2006, SCIENCE, V311, P1008, DOI 10.1126/science.1122511
   Flavell SW, 2008, ANNU REV NEUROSCI, V31, P563, DOI 10.1146/annurev.neuro.31.060407.125631
   Giacometti E, 2007, P NATL ACAD SCI USA, V104, P1931, DOI 10.1073/pnas.0610593104
   GREENBERG ME, 1986, SCIENCE, V234, P80, DOI 10.1126/science.3749894
   Greer PL, 2008, NEURON, V59, P846, DOI 10.1016/j.neuron.2008.09.002
   Greer PL, 2010, CELL, V140, P704, DOI 10.1016/j.cell.2010.01.026
   Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
   Han JM, 2011, FEBS LETT, V585, P973, DOI 10.1016/j.febslet.2011.02.001
   Hardingham GE, 2001, NAT NEUROSCI, V4, P565, DOI 10.1038/88380
   Harlow EG, 2010, NEURON, V65, P385, DOI 10.1016/j.neuron.2010.01.024
   Hong EJ, 2008, NEURON, V60, P610, DOI 10.1016/j.neuron.2008.09.024
   Hou LF, 2006, NEURON, V51, P441, DOI 10.1016/j.neuron.2006.07.005
   Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699
   Hung AY, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009842
   Iijima T, 2011, CELL, V147, P1601, DOI 10.1016/j.cell.2011.11.028
   Jiang YH, 1998, NEURON, V21, P799, DOI 10.1016/S0896-6273(00)80596-6
   Kandel ER, 2001, SCIENCE, V294, P1030, DOI 10.1126/science.1067020
   Kang HJ, 1996, SCIENCE, V273, P1402, DOI 10.1126/science.273.5280.1402
   Kelleher RJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035003
   Kelleher RJ, 2004, CELL, V116, P467, DOI 10.1016/S0092-8674(04)00115-1
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Kim J, 2008, P NATL ACAD SCI USA, V105, P9087, DOI 10.1073/pnas.0803448105
   Kim TK, 2010, NATURE, V465, P182, DOI 10.1038/nature09033
   Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
   Lee SH, 2008, SCIENCE, V319, P1253, DOI 10.1126/science.1150541
   Li HD, 2011, NAT NEUROSCI, V14, P1001, DOI 10.1038/nn.2866
   Lin YX, 2008, NATURE, V455, P1198, DOI 10.1038/nature07319
   Luscher C, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005710
   Malenka RC, 2004, NEURON, V44, P5, DOI 10.1016/j.neuron.2004.09.012
   Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
   Missler M, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005694
   Moretti P, 2006, J NEUROSCI, V26, P319, DOI 10.1523/JNEUROSCI.2623-05.2006
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   Muddashetty RS, 2011, MOL CELL, V42, P673, DOI 10.1016/j.molcel.2011.05.006
   Naisbitt S, 1999, NEURON, V23, P569, DOI 10.1016/S0896-6273(00)80809-0
   Narayanan U, 2007, J NEUROSCI, V27, P14349, DOI 10.1523/JNEUROSCI.2969-07.2007
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Niere F, 2012, J NEUROSCI, V32, P5924, DOI 10.1523/JNEUROSCI.4650-11.2012
   Noutel J, 2011, NEURON, V70, P35, DOI 10.1016/j.neuron.2011.03.001
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Osterweil EK, 2010, J NEUROSCI, V30, P15616, DOI 10.1523/JNEUROSCI.3888-10.2010
   Park S, 2008, NEURON, V59, P70, DOI 10.1016/j.neuron.2008.05.023
   Pasca SP, 2011, NAT MED, V17, P1657, DOI 10.1038/nm.2576
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Pfeiffer BE, 2010, NEURON, V66, P191, DOI 10.1016/j.neuron.2010.03.017
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Pulipparacharuvil S, 2008, NEURON, V59, P621, DOI 10.1016/j.neuron.2008.06.020
   Sala C, 2001, NEURON, V31, P115, DOI 10.1016/S0896-6273(01)00339-7
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
   Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
   Sheng M, 2011, CSH PERSPECT BIOL, V3, DOI 10.1101/cshperspect.a005678
   Skene PJ, 2010, MOL CELL, V37, P457, DOI 10.1016/j.molcel.2010.01.030
   Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Thyagarajan A, 2010, CELL, V143, P456, DOI 10.1016/j.cell.2010.09.025
   van Woerden GM, 2007, NAT NEUROSCI, V10, P280, DOI 10.1038/nn1845
   Wallace ML, 2012, NEURON, V74, P793, DOI 10.1016/j.neuron.2012.03.036
   Waung MW, 2008, NEURON, V59, P84, DOI 10.1016/j.neuron.2008.05.014
   WIESEL TN, 1982, NATURE, V299, P583, DOI 10.1038/299583a0
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
   Yashiro K, 2009, NAT NEUROSCI, V12, P777, DOI 10.1038/nn.2327
   Zalfa F, 2003, CELL, V112, P317, DOI 10.1016/S0092-8674(03)00079-5
   Zhou J, 2012, CURR OPIN NEUROBIOL, V22, P873, DOI 10.1016/j.conb.2012.05.004
   Zhou ZL, 2006, NEURON, V52, P255, DOI 10.1016/j.neuron.2006.09.037
   Zoghbi HY, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a009886
NR 98
TC 89
Z9 93
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD JAN 17
PY 2013
VL 493
IS 7432
BP 327
EP 337
DI 10.1038/nature11860
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 071TA
UT WOS:000313615900039
PM 23325215
ER

PT J
AU Gkogkas, CG
   Khoutorsky, A
   Ran, I
   Rampakakis, E
   Nevarko, T
   Weatherill, DB
   Vasuta, C
   Yee, S
   Truitt, M
   Dallaire, P
   Major, F
   Lasko, P
   Ruggero, D
   Nader, K
   Lacaille, JC
   Sonenberg, N
AF Gkogkas, Christos G.
   Khoutorsky, Arkady
   Ran, Israeli
   Rampakakis, Emmanouil
   Nevarko, Tatiana
   Weatherill, Daniel B.
   Vasuta, Cristina
   Yee, Stephanie
   Truitt, Morgan
   Dallaire, Paul
   Major, Francois
   Lasko, Paul
   Ruggero, Davide
   Nader, Karim
   Lacaille, Jean-Claude
   Sonenberg, Nahum
TI Autism-related deficits via dysregulated eIF4E-dependent translational
   control
SO NATURE
LA English
DT Article
ID FRAGILE-X-SYNDROME; COPY-NUMBER VARIATION; TUBEROUS-SCLEROSIS;
   ULTRASONIC VOCALIZATIONS; INHIBITORY SYNAPSES; SYNAPTIC PLASTICITY;
   SPECTRUM DISORDERS; LEARNING-DEFICITS; REPRESSOR 4E-BP2; MOUSE MODELS
AB Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is thought to cause autism spectrum disorders (ASDs). The mammalian target of rapamycin (mTOR) is strongly implicated in ASDs by means of upstream signalling; however, downstream regulatory mechanisms are ill-defined. Here we show that knockout of the eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2)-an eIF4E repressor downstream of mTOR-or eIF4E overexpression leads to increased translation of neuroligins, which are postsynaptic proteins that are causally linked to ASDs. Mice that have the gene encoding 4E-BP2 (Eif4ebp2) knocked out exhibit an increased ratio of excitatory to inhibitory synaptic inputs and autistic-like behaviours (that is, social interaction deficits, altered communication and repetitive/stereotyped behaviours). Pharmacological inhibition of eIF4E activity or normalization of neuroligin 1, but not neuroligin 2, protein levels restores the normal excitation/inhibition ratio and rectifies the social behaviour deficits. Thus, translational control by eIF4E regulates the synthesis of neuroligins, maintaining the excitation-to-inhibition balance, and its dysregulation engenders ASD-like phenotypes.
C1 [Gkogkas, Christos G.; Khoutorsky, Arkady; Rampakakis, Emmanouil; Nevarko, Tatiana; Sonenberg, Nahum] McGill Univ, Dept Biochem, Montreal, PQ H3A 1A3, Canada.
   [Gkogkas, Christos G.; Khoutorsky, Arkady; Rampakakis, Emmanouil; Nevarko, Tatiana; Sonenberg, Nahum] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada.
   [Ran, Israeli; Weatherill, Daniel B.; Vasuta, Cristina; Lacaille, Jean-Claude] Univ Montreal, GRSNC, Montreal, PQ H3C 3J7, Canada.
   [Ran, Israeli; Weatherill, Daniel B.; Vasuta, Cristina; Lacaille, Jean-Claude] Univ Montreal, Dept Physiol, Montreal, PQ H3C 3J7, Canada.
   [Rampakakis, Emmanouil] JSS Med Res Inc, Montreal, PQ H4S 1N8, Canada.
   [Yee, Stephanie; Lasko, Paul] McGill Univ, Dept Biol, Montreal, PQ H3G 0B1, Canada.
   [Truitt, Morgan; Ruggero, Davide] Univ Calif San Francisco, Sch Med, San Francisco, CA 94158 USA.
   [Truitt, Morgan; Ruggero, Davide] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Dept Urol, San Francisco, CA 94158 USA.
   [Dallaire, Paul; Major, Francois] Univ Montreal, Dept Comp Sci, Montreal, PQ H3C 3J7, Canada.
   [Dallaire, Paul; Major, Francois] Univ Montreal, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada.
   [Nader, Karim] McGill Univ, Dept Psychol, Montreal, PQ H3A 1B1, Canada.
RP Sonenberg, N (reprint author), McGill Univ, Dept Biochem, Montreal, PQ H3A 1A3, Canada.
EM jean-claude.lacaille@umontreal.ca; nahum.sonenberg@mcgill.ca
RI Ran, Israeli/B-2432-2009; Lasko, Paul/C-6761-2014
OI Ran, Israeli/0000-0003-4824-6416; Lasko, Paul/0000-0002-4037-3501
FU Canadian Institutes of Health Research [MOP-114994, MOP-10848,
   MOP-93679, MOP-44050]; Autism Speaks [7109]; Fonds de la Recherche en
   Sante du Quebec (FRSQ; Groupe de Recherche sur le Systeme Nerveux
   Central); National Institutes of Health [NIH RO1 CA154916, NIH RO1
   CA140456]; Canada Research Chair in Cellular and Molecular
   Neurophysiology; Savoy Foundation
FX This work was supported by the Canadian Institutes of Health Research
   (N.S., MOP-114994; J.-C.L., MOP-10848; P.D. and F.M., MOP-93679; and
   P.L. and N.S., MOP-44050), Autism Speaks (Grant 7109 to N.S.), and the
   Fonds de la Recherche en Sante du Quebec (J.-C.L. FRSQ; Groupe de
   Recherche sur le Systeme Nerveux Central), and the National Institutes
   of Health (D.R.; NIH RO1 CA154916 and NIH RO1 CA140456). D.R. is a
   Leukemia & Lymphoma Society Scholar. J.-C.L. is the recipient of the
   Canada Research Chair in Cellular and Molecular Neurophysiology. I.R.
   was supported by a Fellowship of the Savoy Foundation. We thank Y.
   Svitkin, A. Parsyan, E. Petroulakis, R. Karni and V. Polunovski for
   advice; K. Gamache, A. Sylvestre, S. Perreault, C. Lister and I. Harvey
   for technical assistance; T. Alain for assistance with lentiviral
   titration; S. Hamdani for assistance with USVs; and W. Sossin and P.
   Skehel for critical reading of the manuscript.
CR Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   Banko JL, 2005, J NEUROSCI, V25, P9581, DOI 10.1523/JNEUROSCI.2423-05.2005
   Banko JL, 2007, NEUROBIOL LEARN MEM, V87, P248, DOI 10.1016/j.nlm.2006.08.012
   Bateup HS, 2011, J NEUROSCI, V31, P8862, DOI 10.1523/JNEUROSCI.1617-11.2011
   Bidinosti M, 2010, MOL CELL, V37, P797, DOI 10.1016/j.molcel.2010.02.022
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Chubykin AA, 2007, NEURON, V54, P919, DOI 10.1016/j.neuron.2007.05.029
   Cornew L, 2012, J AUTISM DEV DISORD, V42, P1884, DOI 10.1007/s10803-011-1431-6
   Dahlhaus R, 2010, HIPPOCAMPUS, V20, P305, DOI 10.1002/hipo.20630
   Ehninger D, 2008, NAT MED, V14, P843, DOI 10.1038/nm1788
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Graff JR, 2007, J CLIN INVEST, V117, P2638, DOI 10.1172/JCI32044
   Hay N, 2004, GENE DEV, V18, P1926, DOI 10.1101/gad.1212704
   Hoeffer CA, 2008, NEURON, V60, P832, DOI 10.1016/j.neuron.2008.09.037
   Hoeffer CA, 2012, GENES BRAIN BEHAV, V11, P332, DOI 10.1111/j.1601-183X.2012.00768.x
   Hoeffer CA, 2011, P NATL ACAD SCI USA, V108, P3383, DOI 10.1073/pnas.1013063108
   Jeste SS, 2008, J CHILD NEUROL, V23, P520, DOI 10.1177/0883073807309788
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   KOROMILAS AE, 1992, EMBO J, V11, P4153
   Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
   Larsson O, 2012, P NATL ACAD SCI USA, V109, P8977, DOI 10.1073/pnas.1201689109
   Levinson JN, 2005, NEURON, V48, P171, DOI 10.1016/j.neuron.2005.09.017
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Luikart BW, 2011, J NEUROSCI, V31, P4345, DOI 10.1523/JNEUROSCI.0061-11.2011
   Moerke NJ, 2007, CELL, V128, P257, DOI 10.1016/j.cell.2006.11.046
   Napoli I, 2008, CELL, V134, P1042, DOI 10.1016/j.cell.2008.07.031
   Neves-Pereira M, 2009, J MED GENET, V46, P759, DOI 10.1136/jmg.2009.066852
   Nowicki ST, 2007, J DEV BEHAV PEDIATR, V28, P133, DOI 10.1097/01.DBP.0000267563.18952.c9
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   PAUSE A, 1994, NATURE, V371, P762, DOI 10.1038/371762a0
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Petroulakis E, 2009, CANCER CELL, V16, P439, DOI 10.1016/j.ccr.2009.09.025
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Ruggero D, 2004, NAT MED, V10, P484, DOI 10.1038/nm1042
   Scattoni ML, 2009, NEUROSCI BIOBEHAV R, V33, P508, DOI 10.1016/j.neubiorev.2008.08.003
   Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   Uhlhaas PJ, 2012, NEURON, V75, P963, DOI 10.1016/j.neuron.2012.09.004
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
   Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
   Young DM, 2010, P NATL ACAD SCI USA, V107, P11074, DOI 10.1073/pnas.1005620107
   Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
   Zhou J., 2012, CURR OPIN NEUROBIOL
NR 46
TC 84
Z9 86
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD JAN 17
PY 2013
VL 493
IS 7432
BP 371
EP U113
DI 10.1038/nature11628
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 071TA
UT WOS:000313615900044
PM 23172145
ER

PT J
AU Santini, E
   Huynh, TN
   MacAskill, AF
   Carter, AG
   Pierre, P
   Ruggero, D
   Kaphzan, H
   Klann, E
AF Santini, Emanuela
   Huynh, Thu N.
   MacAskill, Andrew F.
   Carter, Adam G.
   Pierre, Philippe
   Ruggero, Davide
   Kaphzan, Hanoch
   Klann, Eric
TI Exaggerated translation causes synaptic and behavioural aberrations
   associated with autism
SO NATURE
LA English
DT Article
ID FRAGILE-X-SYNDROME; LONG-TERM DEPRESSION; PROTEIN-SYNTHESIS;
   TUBEROUS-SCLEROSIS; DENDRITIC SPINES; MUTANT MICE; INHIBITION; MEMORY;
   MODEL; DYSFUNCTIONS
AB Autism spectrum disorders (ASDs) are an early onset, heterogeneous group of heritable neuropsychiatric disorders with symptoms that include deficits in social interaction skills, impaired communication abilities, and ritualistic-like repetitive behaviours(1,2). One of the hypotheses for a common molecular mechanism underlying ASDs is altered translational control resulting in exaggerated protein synthesis(3). Genetic variants in chromosome 4q, which contains theEIF4E locus, have been described in patients with autism(4,5). Importantly, a rare single nucleotide polymorphism has been identified in autism that is associated with increased promoter activity in the EIF4E gene(6). Here we show that genetically increasing the levels of eukaryotic translation initiation factor 4E (eIF4E) in mice(7) results in exaggerated cap-dependent translation and aberrant behaviours reminiscent of autism, including repetitive and perseverative behaviours and social interaction deficits. Moreover, these autistic-like behaviours are accompanied by synaptic pathophysiology in the medial prefrontal cortex, striatumand hippocampus. The autistic-like behaviours displayed by the eIF4E-transgenic mice are corrected by intracerebroventricular infusions of the cap-dependent translation inhibitor 4EGI-1. Our findings demonstrate a causal relationship between exaggerated cap-dependent translation, synaptic dysfunction and aberrant behaviours associated with autism.
C1 [Santini, Emanuela; Huynh, Thu N.; MacAskill, Andrew F.; Carter, Adam G.; Kaphzan, Hanoch; Klann, Eric] NYU, Ctr Neural Sci, New York, NY 10003 USA.
   [Pierre, Philippe] Aix Marseille Univ, Ctr Immunol Marseille Luminy, F-13288 Marseille, France.
   [Pierre, Philippe] INSERM, U1104, F-13288 Marseille, France.
   [Pierre, Philippe] CNRS, URM 7280, F-13288 Marseille, France.
   [Ruggero, Davide] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Sch Med, Dept Urol, San Francisco, CA 94143 USA.
RP Klann, E (reprint author), NYU, Ctr Neural Sci, New York, NY 10003 USA.
EM eklann@cns.nyu.edu
RI Huynh, Thu/I-5864-2014
OI Huynh, Thu/0000-0002-7625-5101
FU National Institutes of Health (NIH) [NS034007, NS047384, NS078718];
   Department of Defense CDMRP [W81XWH-11-1-0389]; NIH [CA154916]; Wellcome
   Trust
FX We would like to thank J. LeDoux and members of his laboratory for their
   technical support and suggestions. We would also like to thank D. St
   Clair and Z. Miedzybrodzka for their comments on the manuscript. This
   research was supported by National Institutes of Health (NIH) grants
   NS034007, NS047384 and NS078718, and Department of Defense CDMRP award
   W81XWH-11-1-0389 (E. K.), NIH grant CA154916 (D. R.) and the Wellcome
   Trust (A.F.M.).
CR Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   Banko JL, 2007, NEUROBIOL LEARN MEM, V87, P248, DOI 10.1016/j.nlm.2006.08.012
   Blundell J, 2010, J NEUROSCI, V30, P2115, DOI 10.1523/JNEUROSCI.4517-09.2010
   Borgkvist A, 2006, MOL CELL NEUROSCI, V31, P293, DOI 10.1016/j.mcn.2005.09.018
   CALABRESI P, 1992, J NEUROSCI, V12, P4224
   Chalifoux JR, 2010, NEURON, V66, P101, DOI 10.1016/j.neuron.2010.03.012
   Chevere-Torres I, 2012, NEUROBIOL DIS, V45, P156, DOI 10.1016/j.nbd.2011.07.018
   Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
   Dumitriu D, 2011, NAT PROTOC, V6, P1391, DOI 10.1038/nprot.2011.389
   Ehninger D, 2008, NAT MED, V14, P843, DOI 10.1038/nm1788
   Errico F, 2008, MOL CELL NEUROSCI, V37, P335, DOI 10.1016/j.mcn.2007.10.007
   Fineberg NA, 2010, NEUROPSYCHOPHARMACOL, V35, P591, DOI 10.1038/npp.2009.185
   Franklin K.B.J., 2007, MOUSE BRAIN STEREOTA, V3rd
   Gingras AC, 2001, GENE DEV, V15, P2852
   Hoeffer CA, 2008, NEURON, V60, P832, DOI 10.1016/j.neuron.2008.09.037
   Hoeffer CA, 2011, P NATL ACAD SCI USA, V108, P3383, DOI 10.1073/pnas.1013063108
   Hou LF, 2006, NEURON, V51, P441, DOI 10.1016/j.neuron.2006.07.005
   Huber KM, 2000, SCIENCE, V288, P1254, DOI 10.1126/science.288.5469.1254
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
   Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
   Moerke NJ, 2007, CELL, V128, P257, DOI 10.1016/j.cell.2006.11.046
   Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
   Neves-Pereira M, 2009, J MED GENET, V46, P759, DOI 10.1136/jmg.2009.066852
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Qin M, 2005, J NEUROSCI, V25, P5087, DOI 10.1523/JNEUROSCI.0093-05.2005
   Qiu AQ, 2010, J AM ACAD CHILD PSY, V49, P539, DOI 10.1016/j.jaac.2010.02.012
   Rapin I, 2008, PEDIATR CLIN N AM, V55, P1129, DOI 10.1016/j.pcl.2008.07.005
   Ronesi JA, 2012, NAT NEUROSCI, V15, P431, DOI 10.1038/nn.3033
   Ruggero D, 2004, NAT MED, V10, P484, DOI 10.1038/nm1042
   Schmidt EK, 2009, NAT METHODS, V6, P275, DOI [10.1038/nmeth.1314, 10.1038/NMETH.1314]
   Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
   Yonan AL, 2003, AM J HUM GENET, V73, P886, DOI 10.1086/378778
   Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
NR 38
TC 58
Z9 59
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD JAN 17
PY 2013
VL 493
IS 7432
BP 411
EP U158
DI 10.1038/nature11782
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 071TA
UT WOS:000313615900053
PM 23263185
ER

PT J
AU Castro-Gago, M
   Perez-Gay, L
   Gomez-Lado, C
   Dacruz, D
   Barros-Angueira, F
AF Castro-Gago, Manuel
   Perez-Gay, Laura
   Gomez-Lado, Carmen
   Dacruz, David
   Barros-Angueira, Francisco
TI 16p11.2 microdeletion associated to early onset benign childhood
   seizures
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Letter
ID PAROXYSMAL KINESIGENIC DYSKINESIA; AUTISM; CONVULSIONS; DELETIONS;
   OBESITY
C1 [Castro-Gago, Manuel; Perez-Gay, Laura; Gomez-Lado, Carmen; Dacruz, David] Univ Santiago de Compostela, Hosp Clin Univ, Serv Neuropediat, Santiago De Compostela, A Coruna, Spain.
   [Barros-Angueira, Francisco] Fdn Publ Gallega Med Xen, Santiago De Compostela, A Coruna, Spain.
RP Castro-Gago, M (reprint author), Hosp Clin Univ, Serv Neuropediat, Choupana S-N, E-15706 Santiago De Compostela, A Coruna, Spain.
EM manuel.castro.gago@usc.es
CR Aicardi J, 2009, DIS NERVOUS SYSTEM C
   Bachmann-Gagescu R, 2010, GENET MED, V12, P641, DOI 10.1097/GIM.0b013e3181ef4286
   Ballif BC, 2007, NAT GENET, V39, P1071, DOI 10.1038/ng2107
   Barge-Schaapveld DQCM, 2011, AM J MED GENET A, V155A, P1066, DOI 10.1002/ajmg.a.33991
   Battaglia A, 2009, AM J MED GENET A, V149A, P1200, DOI 10.1002/ajmg.a.32847
   Bochukova EG, 2010, NATURE, V463, P666, DOI 10.1038/nature08689
   Caraballo R, 1997, REV NEUROLOGIA, V25, P682
   Caraballo RH, 2003, EPILEPTIC DISORD, V5, P45
   Ciuladaite Z, 2011, J APPL GENET, V52, P443, DOI 10.1007/s13353-011-0063-z
   Dale RC, 2011, NEUROLOGY, V77, P1401, DOI 10.1212/WNL.0b013e31823152d7
   Fejerman N., 2007, NEUROLOGIA PEDIAT
   Hanson E, 2010, J DEV BEHAV PEDIATR, V31, P649, DOI 10.1097/DBP.0b013e3181ea50ed
   Kumar RA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004582
   Lee HY, 2012, CELL REPORTS, V1, P1, DOI DOI 10.1016/J.CELREP.2011.1011.1001
   Lipton J, 2009, NEUROLOGY, V73, P479, DOI 10.1212/WNL.0b013e3181b16393
   Rosenfeld JA, 2010, J NEURODEV DISORD, V2, P26, DOI 10.1007/s11689-009-9037-4
   Sampson MG, 2010, AM J MED GENET A, V152A, P2618, DOI 10.1002/ajmg.a.33628
   Shen Y, 2010, AM J MED GENET B, V156, P225
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
NR 19
TC 0
Z9 1
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD JAN 16
PY 2013
VL 56
IS 2
BP 125
EP 127
PG 3
WC Clinical Neurology
SC Neurosciences & Neurology
GA 083AU
UT WOS:000314435900009
PM 23307360
ER

PT J
AU Classen, S
   Monahan, M
AF Classen, Sherrilene
   Monahan, Miriam
TI Evidence-Based Review on Interventions and Determinants of Driving
   Performance in Teens with Attention Deficit Hyperactivity Disorder or
   Autism Spectrum Disorder
SO TRAFFIC INJURY PREVENTION
LA English
DT Article
DE evidence-based practice; adolescents; attention deficit disorder with
   hyperactivity; pervasive disorders; automobile driving
ID YOUNG-ADULTS; DEFICIT/HYPERACTIVITY DISORDER; UNITED-STATES; ADHD;
   DRIVERS; AMPHETAMINE; SYMPTOMS; CHILDREN; INJURY
AB Objective: We conducted an evidence-based review of intervention studies and predictor studies related to driving outcomes in teens with attention deficithyperactivity disorder (ADHD) or autism spectrum disorder (ASD). Methods: Ten primary studies were classified using the American Academy of Neurology's criteria (class IIV, I = highest level of evidence). We provided recommendations including Level A: intervention/factors are effective/predictive or not; Level B: probably effective/predictive or not; Level C: possibly effective/predictive or not; Level U: no recommendations. Results: For the intervention studies we identified 1 Class II and 1 Class III study; for predictor studies, we identified 7 ADHD studies consisting of 1 Class II and 6 Class III studies. Only 1 Class III ASD study was found. In synopsizing the evidence, the following recommendations are made for the intervention studies pertaining to on-road performance in teens with ADHD: a multimodal intervention is possibly effective in improving driving performance (Level C); stimulants possibly do not affect driving negatively (Level C); no recommendations can be made for hazard perception training in ADHD or ASD (Level U). Consider the following recommendations useful for simulated driving performance: Stimulants possibly improve driving performance (Level C); ADHD diagnosis and being unmedicated possibly worsen driving performance (Level C); no recommendations for driving in low-stimulus conditions (Level U). From self-/proxy report, no recommendations can be made related to gender or ADHD subtype affecting adverse driving outcomes (Level U). Conclusion: Class I studies with Level A recommendations, currently lacking in the literature, are urgently needed to make clear the mechanism underlying driving performance outcomes in ADHD and ASD. Supplementary materials are available for this article. Go to the publisher's online edition of Traffic Injury Prevention for the following supplemental resource: Table: Evidence-based Synopsis of ADHD, ASD and Driving Performance: Variables, Sample, Findings & Rationale
C1 [Classen, Sherrilene; Monahan, Miriam] Univ Florida, Coll Publ Hlth & Hlth Profess, Inst Mobil Act & Participat, Gainesville, FL 32610 USA.
   [Classen, Sherrilene; Monahan, Miriam] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Occupat Therapy, Gainesville, FL 32610 USA.
RP Classen, S (reprint author), Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Occupat Therapy, POB 100164, Gainesville, FL 32610 USA.
EM sclassen@phhp.ufl.edu
FU UF&Shands Quasi Endowment Fund; Institute for Mobility, Activity and
   Participation
FX This study was funded by the 2011-2012 UF&Shands Quasi Endowment Fund
   (principal investigator: Classen). The Institute for Mobility, Activity
   and Participation provided infrastructure and support.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Barkley RA, 2002, J INT NEUROPSYCH SOC, V8, P655, DOI 10.1017/S1355617702801345
   Centers for Disease Control and Prevention, 2012, CDC EST 1 88 CHILDR
   Centers for Disease Control and Prevention, 2010, FACTS ADHD
   Centers for Disease Control and Prevention, 2008, TEEN DRIV FACT SHEET
   Visser S. N., 2010, Morbidity and Mortality Weekly Report, V59, P1439
   Classen S, 2009, AM J OCCUP THER, V63, P580
   Classen S, 2012, EPILEPSY BEHAV, V23, P103, DOI 10.1016/j.yebeh.2011.11.015
   Cooper HM, 1994, HDB RES SYNTHESIS
   Cox DJ, 2008, J CHILD ADOL PSYCHOP, V18, P1, DOI 10.1089/cap.2006.0141
   Di Stefano M, 2005, DRIVER REHABILITATIO, P255
   Edlund W, 2004, CLIN PRACTICE GUIDEL
   Fabiano GA, 2010, COGN BEHAV PRACT, V18, P267
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Iverson DJ, 2010, NEUROLOGY, V74, P1316, DOI 10.1212/WNL.0b013e3181da3b0f
   Jerome Laurence, 2006, J Can Acad Child Adolesc Psychiatry, V15, P105
   Kay GG, 2009, J ATTEN DISORD, V12, P316, DOI 10.1177/1087054708322986
   Martins S, 2004, J CHILD ADOL PSYCHOP, V14, P195, DOI 10.1089/1044546041649066
   McIntosh G, 2000, WMJ, V99, P31
   Monahan M, AM OCCUPATIONAL THER
   Monahan M, 2012, AM OCCUPATIONAL THER
   National Institute of Mental Health, 2011, WHAT IS AUT SPECTR D
   National Institute of Mental Health, 2011, ATT DEF HYP DIS ADHD
   Naumann RB, 2010, TRAFFIC INJ PREV, V11, P353, DOI 10.1080/15389588.2010.486429
   Oliver ML, 2012, J ATTEN DISORD, V16, P478, DOI 10.1177/1087054710397132
   Poulsen AA, 2010, AUST NZ J PSYCHIAT, V44, P528, DOI 10.3109/00048671003596048
   Reimer B, 2010, ACCIDENT ANAL PREV, V42, P842, DOI 10.1016/j.aap.2009.06.021
   Rosenbloom T, 2011, ACCIDENT ANAL PREV, V43, P128, DOI 10.1016/j.aap.2010.08.002
   Sheppard E., 2009, J AUTISM DEV DISORD, V40, P504, DOI 10.1007/s10803-009-0890-5
   Thompson AL, 2007, J PEDIATR PSYCHOL, V32, P745, DOI 10.1093/jpepsy/jsm002
   U.S. Census Bureau, 2011, POP AG SEX RAC HISP
   Weafer J, 2008, EXP CLIN PSYCHOPHARM, V16, P251, DOI 10.1037/1064-1297.16.3.251
NR 33
TC 6
Z9 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1538-9588
J9 TRAFFIC INJ PREV
JI Traffic Inj. Prev.
PD JAN 15
PY 2013
VL 14
IS 2
BP 188
EP 193
DI 10.1080/15389588.2012.700747
PG 6
WC Public, Environmental & Occupational Health; Transportation
SC Public, Environmental & Occupational Health; Transportation
GA 079YR
UT WOS:000314208600010
PM 23343028
ER

PT J
AU Bellman, M
   Byrne, O
   Sege, R
AF Bellman, Martin
   Byrne, Orlaith
   Sege, Robert
TI Developmental assessment of children
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Review
ID YOUNG-CHILDREN; PARENTS CONCERNS; CHILDHOOD; DISORDERS; SURVEILLANCE;
   ACCURACY; OUTCOMES; PROJECT; HEALTH; AUTISM
C1 [Bellman, Martin] Royal Free Hosp, Dept Paediat, London NW3 2QG, England.
   [Byrne, Orlaith] Birmingham Community Healthcare NHS Trust, Dept Child Hlth, Birmingham, W Midlands, England.
   [Sege, Robert] Boston Univ, Dept Pediat, Boston, MA 02215 USA.
RP Bellman, M (reprint author), Royal Free Hosp, Dept Paediat, Pond St, London NW3 2QG, England.
EM m.bellman@nhs.net
CR Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   BAX M, 1987, DEV MED CHILD NEUROL, V29, P40
   Bellman M, 1997, SCHEDULE GROWING SKI
   BELLMAN MH, 1985, CHILD CARE HLTH DEV, V11, P309, DOI 10.1111/j.1365-2214.1985.tb00472.x
   Blanchard LT, 2006, PEDIATRICS, V117, pE1202, DOI 10.1542/peds.2005-2606
   COCHRANE AL, 1971, BRIT MED BULL, V27, P3
   Duby JC, 2006, PEDIATRICS, V118, P405, DOI 10.1542/peds.2006-1231
   Department of Health, 2009, HLTH CHILD PROGR
   Engle PL, 2011, LANCET, V378, P1339, DOI 10.1016/S0140-6736(11)60889-1
   Glascoe FP, 1997, PEDIATRICS, V99, P522, DOI 10.1542/peds.99.4.522
   Glascoe FP, 1999, AMBULATORY CHILD HLT, V5, P197
   GLASCOE FP, 1993, J EARLY INTERVENTION, V17, P368
   Glascoe FP, 2000, CHILD CARE HLTH DEV, V26, P137, DOI 10.1046/j.1365-2214.2000.00173.x
   GLASCOE FP, 1992, PEDIATRICS, V89, P1221
   Gomby DS, 1995, FUTURE CHILD, V5, P6, DOI 10.2307/1602365
   Guralnik MJ, 1997, EFFECTIVENESS EARLY
   Hagan JF, 2008, BRIGHT FUTURES GUIDE, V3rd
   Heckman JJ, 2007, REV AGR ECON, V29, P446, DOI 10.1111/j.1467-9353.2007.00359.x
   Horridge KA, 2011, ARCH DIS CHILDHOOD-E, V96, P9, DOI 10.1136/adc.2009.182436
   Kelly Y, 2006, DEV MED CHILD NEUROL, V48, P824
   Klamer A, 2005, ACTA PAEDIATR, V94, P1327, DOI 10.1080/08035250510042825
   Kohler L, 2003, CHILD CARE HLTH DEV, V29, P551, DOI 10.1046/j.1365-2214.2003.00375.x
   KPMG, 2011, REV EV EFF EARL CHIL
   Lake A, 2011, LANCET, V378, P1277, DOI 10.1016/S0140-6736(11)61450-5
   McCain Margaret, 1999, REVERSING REAL BRAIN
   Nelson CA, 2007, SCIENCE, V318, P1937, DOI 10.1126/science.1143921
   Perry B, 2002, BRAIN MIND, V3, P79, DOI 10.1023/A:1016557824657
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Sharma A, 2011, ARCH DIS CHILDHOOD-E, V96, P162, DOI 10.1136/adc.2009.175901
   Sheridan M, 2007, BIRTH 5 YEARS CHILDR
   Sheridan MA, 2012, P NATL ACAD SCI USA, V109, P12927, DOI 10.1073/pnas.1200041109
   Shonkoff J. P., 2000, NEURONS NEIGHBORHOOD
   Squires J, 1997, J PEDIATR PSYCHOL, V22, P313, DOI 10.1093/jpepsy/22.3.313
   Voigt RG, 2007, CLIN PEDIATR, V46, P523, DOI 10.1177/0009922806299100
   Williams AN, 2004, DEV MED CHILD NEUROL, V46, P502, DOI 10.1017/S0012162204240828
   WILSON JMG, 1968, WHO CHRON, V22, P473
   Windsor J, 2011, CHILD DEV, V82, P1040, DOI 10.1111/j.1467-8624.2011.01604.x
NR 37
TC 4
Z9 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD JAN 15
PY 2013
VL 346
AR e8687
DI 10.1136/bmj.e8687
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA 075ER
UT WOS:000313867100006
PM 23321410
ER

PT J
AU Kim, SH
   Fonov, VS
   Dietrich, C
   Vachet, C
   Hazlett, HC
   Smith, RG
   Graves, MM
   Piven, J
   Gilmore, JH
   Dager, SR
   McKinstry, RC
   Paterson, S
   Evans, AC
   Collins, DL
   Gerig, G
   Styner, MA
AF Kim, Sun Hyung
   Fonov, Vladimir S.
   Dietrich, Cheryl
   Vachet, Clement
   Hazlett, Heather C.
   Smith, Rachel G.
   Graves, Michael M.
   Piven, Joseph
   Gilmore, John H.
   Dager, Stephen R.
   McKinstry, Robert C.
   Paterson, Sarah
   Evans, Alan C.
   Collins, D. Louis
   Gerig, Guido
   Styner, Martin Andreas
CA IBIS Network
TI Adaptive prior probability and spatial temporal intensity change
   estimation for segmentation of the one-year-old human brain
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE Myelination; Expectation Maximization algorithm; Tissue segmentation;
   Intensity growth map; Partial volume estimation
ID MAGNETIZATION-TRANSFER RATIO; WHITE-MATTER MATURATION;
   CEREBRAL-BLOOD-FLOW; NEONATAL BRAIN; MR-IMAGES; PRETERM SUBJECTS;
   CHILDREN; AUTISM; MODEL; CLASSIFICATION
AB The degree of white matter (WM) myelination is rather inhomogeneous across the brain. White matter appears differently across the cortical lobes in MR images acquired during early postnatal development. Specifically at 1-year of age, the gray/white matter contrast of MRT1 and T2 weighted images in prefrontal and temporal lobes is reduced as compared to the rest of the brain, and thus, tissue segmentation results commonly show lower accuracy in these lobes. In this novel work, we propose the use of spatial intensity growth maps (IGM) for T1 and 12 weighted images to compensate for local appearance inhomogeneity. The IGM captures expected intensity changes from 1 to 2 years of age, as appearance homogeneity is greatly improved by the age of 24 months. The IGM was computed as the coefficient of a voxel-wise linear regression model between corresponding intensities at 1 and 2 years. The proposed IGM method revealed low regression values of 1-10% in GM and CSF regions, as well as in WM regions at maturation stage of myelination at 1 year. However, in the prefrontal and temporal lobes we observed regression values of 20-25%, indicating that the IGM appropriately captures the expected large intensity change in these lobes mainly due to myelination. The IGM is applied to cross-sectional MRI datasets of 1-year-old subjects via registration, correction and tissue segmentation of the IGM-corrected dataset. We validated our approach in a small leave-one-out study of images with known, manual 'ground truth' segmentations. Published by Elsevier B.V.
C1 [Kim, Sun Hyung; Dietrich, Cheryl; Vachet, Clement; Hazlett, Heather C.; Smith, Rachel G.; Graves, Michael M.; Piven, Joseph; Gilmore, John H.; Styner, Martin Andreas] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA.
   [Fonov, Vladimir S.; Evans, Alan C.; Collins, D. Louis] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada.
   [Gerig, Guido] Univ Utah, Sci Comp & Imaging Inst, Sch Comp, Salt Lake City, UT USA.
   [Styner, Martin Andreas] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC USA.
   [Dager, Stephen R.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA.
   [McKinstry, Robert C.] Washington Univ, Dept Radiol, St Louis, MO USA.
   [Paterson, Sarah] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
RP Kim, SH (reprint author), Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA.
EM shykim@email.unc.edu
RI Pike, Bruce/K-5562-2014
OI Pike, Bruce/0000-0001-8924-683X
FU IBIS (Infant Brain Imaging Study) Network; NIH [HD055741, P50 MH 064065,
   MH070890, HD053000, U54 EB005149-01]; UNC Intellectual and Developmental
   Disabilities Research Center [P30 HD03110, R01 MH091645]
FX Funding was provided primarily from the IBIS (Infant Brain Imaging
   Study) Network, an NIH funded Autism Center of Excellence (HD055741)
   that consists of a consortium of 7 Universities in the U.S. and Canada.
   Clinical Sites: University of North Carolina: J. Piven (IBIS Network
   PI), H.C. Hazlett, C. Chappell; University of Washington: S.R. Dager, A.
   Estes; Washington University: K. Botteron, R.C. McKinstry, J.
   Contstantino, L Flake; Children's Hospital of Philadelphia: R. Schultz,
   S. Paterson; University of Alberta: L. Zwaigenbaum. Data Coordinating
   Center: Montreal Neurological Institute: A. Evans, L Collins, B. Pike,
   V.S. Fonov, R. Aleong, S. Das. Image Processing Core: University of
   Utah: G. Gerig; University of North Carolina: M.A. Styner. Statistical
   Analysis Core: University of North Carolina: H. Gu. Genetics Analysis
   Core: University of North Carolina: P. Sullivan, F. Wright.Additional
   support is provided by the following grants: NIH grants P50 MH 064065
   (JHG, MAS), MH070890 (JHG, MAS), HD053000 (JHG), and UNC Intellectual
   and Developmental Disabilities Research Center P30 HD03110 (MAS, SJS),
   R01 MH091645 (MAS), NIH Roadmap Grant U54 EB005149-01 (MAS).
CR AXEL L, 1987, AM J ROENTGENOL, V148, P418
   Caviness VS, 1996, CEREB CORTEX, V6, P726, DOI 10.1093/cercor/6.5.726
   Claude I, 2004, IEEE T BIO-MED ENG, V51, P617, DOI 10.1109/TBME.2003.821032
   Colby JB, 2011, NEUROIMAGE, V54, P25, DOI 10.1016/j.neuroimage.2010.08.014
   Collins DL, 1995, HUM BRAIN MAPP, V3, P190, DOI 10.1002/hbm.460030304
   COLLINS DL, 1994, J COMPUT ASSIST TOMO, V18, P192
   de Alejo RP, 2003, MAGN RESON IMAGING, V21, P901, DOI 10.1016/S0730-725X(03)00193-0
   Delignon Y, 1997, IEEE T IMAGE PROCESS, V6, P1364, DOI 10.1109/83.624951
   Fonov V, 2011, NEUROIMAGE, V54, P313, DOI 10.1016/j.neuroimage.2010.07.033
   Fonov VJA, 2010, MIAR
   Giedd JN, 1996, CEREB CORTEX, V6, P551, DOI 10.1093/cercor/6.4.551
   Gilmore JH, 2010, AM J PSYCHIAT, V167, P1083, DOI 10.1176/appi.ajp.2010.09101492
   Gilmore JH, 2007, J NEUROSCI, V27, P1255, DOI 10.1523/JNEUROSCI.3339-06.2007
   Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39
   Heimann T, 2009, IEEE T MED IMAGING, V28, P1251, DOI 10.1109/TMI.2009.2013851
   Kim JS, 2005, NEUROIMAGE, V27, P210, DOI 10.1016/j.neuroimage.2005.03.036
   Knickmeyer RC, 2008, J NEUROSCI, V28, P12176, DOI 10.1523/JNEUROSCI.3479-08.2008
   Merisaari H, 2009, J NEUROSCI METH, V182, P110, DOI 10.1016/j.jneumeth.2009.05.026
   Murakami JW, 1999, AM J NEURORADIOL, V20, P1406
   Neil J, 2002, NMR BIOMED, V15, P543, DOI 10.1002/nbm.784
   Nyul LG, 2000, IEEE T MED IMAGING, V19, P143, DOI 10.1109/42.836373
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Prastawa M, 2003, ACAD RADIOL, V10, P1341, DOI 10.1016/S1076-6332(03)00506-3
   Roche A, 2011, MED IMAGE ANAL, V15, P830, DOI 10.1016/j.media.2011.05.002
   Shaw P, 2006, NATURE, V440, P676, DOI 10.1038/nature04513
   Shen S, 2005, IEEE T INF TECHNOL B, V9, P459, DOI 10.1109/TITB.2005.847500
   Shi F, 2010, NEUROIMAGE, V49, P391, DOI 10.1016/j.neuroimage.2009.07.066
   Shi F, 2010, NEUROIMAGE, V51, P684, DOI 10.1016/j.neuroimage.2010.02.025
   Sled JG, 1998, IEEE T MED IMAGING, V17, P87, DOI 10.1109/42.668698
   Smith SM, 2002, HUM BRAIN MAPP, V17, P143, DOI 10.1002/hbm.10062
   Sowell ER, 2004, J NEUROSCI, V24, P8223, DOI 10.1523/JNEUROSCI.1798-04.2004
   Styner MLJ, 2008, INSIGHTJOURNAL, P1
   Takahashi T, 1999, AM J NEURORADIOL, V20, P917
   Tohka J, 2004, NEUROIMAGE, V23, P84, DOI 10.1016/j.neuroimage.2004.05.007
   Tokumaru AM, 1999, AM J NEURORADIOL, V20, P845
   Tzarouchi LC, 2009, NEUROIMAGE, V47, P1148, DOI 10.1016/j.neuroimage.2009.03.072
   van Ginneken BHT, 2007, WORKSH MED IM COMP C, P7
   Van Leemput K, 1999, IEEE T MED IMAGING, V18, P897, DOI 10.1109/42.811270
   Weisenfeld NI, 2009, NEUROIMAGE, V47, P564, DOI 10.1016/j.neuroimage.2009.04.068
   Xydis V, 2006, EUR RADIOL, V16, P215, DOI 10.1007/s00330-005-2796-8
   Xydis V, 2006, PEDIATR RADIOL, V36, P934, DOI 10.1007/s00247-006-0235-x
   Yirmiya N, 2010, J CHILD PSYCHOL PSYC, V51, P432, DOI 10.1111/j.1469-7610.2010.02214.x
   Zhang YY, 2001, IEEE T MED IMAGING, V20, P45, DOI 10.1109/42.906424
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 44
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD JAN 15
PY 2013
VL 212
IS 1
BP 43
EP 55
DI 10.1016/j.jneumeth.2012.09.018
PG 13
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 068UB
UT WOS:000313390600004
PM 23032117
ER

PT J
AU Moran, JM
AF Moran, Joseph M.
TI Lifespan development: The effects of typical aging on theory of mind
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Review
DE Aging; Theory of mind; Mentalizing; Cognitive deficits; Social
   neuroscience
ID HIGH-FUNCTIONING AUTISM; OLD-AGE; EXECUTIVE FUNCTION; PREFRONTAL CORTEX;
   ASPERGER-SYNDROME; SOCIAL COGNITION; MORAL JUDGMENT; EMOTION
   RECOGNITION; PERSPECTIVE-TAKING; FRONTAL-CORTEX
AB Whether typical aging is associated with impairments in social understanding is a topic of critical importance in characterizing the changes that occur in older adulthood. Theory of mind (ToM) refers to the ability to represent other's mental states, and has been tested in a variety of different paradigms in older adults. The overarching research question has been whether ToM abilities may rely on other cognitive abilities, such as processing speed or executive functioning, and as such declines in TOM may reflect a decline in general meta-representational abilities. Alternatively, ToM abilities may be relatively spared, suggesting the acquisition of a sort of social wisdom with advancing age. The preponderance of the evidence is in line with the first possibility: namely. ToM, as measured by paradigms involving faces, cartoons, stories, and videos is typically impaired in social aging, and these impairments are at least partly mediated by impairments in executive functions and fluid intelligence (but not typically by crystallized intelligence). Neuroimaging investigations suggest that older adults who perform as well as younger adults may activate compensatory mechanisms, but are impaired in the brain mechanisms most closely associated with ToM ability when their task performance is impaired. Recent methodological advances allowing continuous rather than categorical assessment of ToM show that ToM may be observed to function independently from general cognition in aging, but further investigation is needed to confirm this point. Implications of these findings for the longstanding discussion regarding Theory of Mind's endangered status as a special cognitive module are discussed. (C) 2012 Elsevier B.V. All rights reserved.
C1 Harvard Univ, Ctr Brain Sci, Dept Psychol, Cambridge, MA 02138 USA.
RP Moran, JM (reprint author), Harvard Univ, Ctr Brain Sci, Dept Psychol, 52 Oxford St,290-01, Cambridge, MA 02138 USA.
EM jmoran@wjh.harvard.edu
CR Adolphs R, 1999, TRENDS COGN SCI, V3, P469, DOI 10.1016/S1364-6613(99)01399-6
   Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
   Astington JW, 2002, NEW IDEAS PSYCHOL, V20, P131, DOI 10.1016/S0732-118X(02)00005-3
   Bailey PE, 2008, AGING MENT HEALTH, V12, P499, DOI 10.1080/13607860802224243
   Bailey PE, 2008, J GERONTOL B-PSYCHOL, V63, pP219
   Baird JA, 2004, NEW DIR CHILD ADOLES, V3, P7
   Baron-Cohen S., 1991, NATURAL THEORIES MIN, P233
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
   BARTSCH K, 1989, CHILD DEV, V60, P946, DOI 10.1111/j.1467-8624.1989.tb03526.x
   Bernstein DM, 2011, EXP AGING RES, V37, P481, DOI 10.1080/0361073X.2011.619466
   BIRCHWOOD M, 1990, BRIT J PSYCHIAT, V157, P853, DOI 10.1192/bjp.157.6.853
   Castelli I, 2010, NEUROPSYCHOLOGIA, V48, P2586, DOI 10.1016/j.neuropsychologia.2010.05.005
   Chandler M, 1996, SHIFTING INTERPRETIV
   Charlton RA, 2009, PSYCHOL AGING, V24, P338, DOI 10.1037/a0015225
   DUNBAR RIM, 1993, BEHAV BRAIN SCI, V16, P681
   Duval C, 2011, CONSCIOUS COGN, V20, P627, DOI 10.1016/j.concog.2010.10.025
   FLETCHER PC, 1995, COGNITION, V57, P109, DOI 10.1016/0010-0277(95)00692-R
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Gallagher HL, 2000, NEUROPSYCHOLOGIA, V38, P11, DOI 10.1016/S0028-3932(99)00053-6
   German TP, 2006, COGNITION, V101, P129, DOI 10.1016/j.cognition.2005.05.007
   Halberstadt J, 2011, PSYCHOL AGING, V26, P133, DOI 10.1037/a0021366
   HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093
   Happe FGE, 1998, DEV PSYCHOL, V34, P358, DOI 10.1037//0012-1649.34.2.358
   Hedden T, 2004, NAT REV NEUROSCI, V5, P87, DOI 10.1038/nrn1323
   Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
   Henry JD, 2006, NEUROPSYCHOLOGIA, V44, P1623, DOI 10.1016/j.neuropsychologia.2006.03.020
   Keightley ML, 2006, PSYCHOL AGING, V21, P558, DOI 10.1037/0882-7974.21.3.558
   Kelley WM, 1998, NEURON, V20, P927, DOI 10.1016/S0896-6273(00)80474-2
   Koenigs M, 2007, NATURE, V446, P908, DOI 10.1038/nature05631
   LESLIE AM, 1992, COGNITION, V43, P225, DOI 10.1016/0010-0277(92)90013-8
   LESLIE AM, 1994, COGNITION, V50, P211, DOI 10.1016/0010-0277(94)90029-9
   LEUNG EHL, 1981, DEV PSYCHOL, V17, P215, DOI 10.1037//0012-1649.17.2.215
   Li X, 2012, INT J PSYCHOL
   Ligneau-Herve C, 2005, J EXP PSYCHOL-APPL, V11, P53, DOI 10.1037/1076-898X.11.1.53
   MacPherson SE, 2002, PSYCHOL AGING, V17, P598, DOI 10.1037//0882-7974.17.4.598
   MANT CM, 1988, DEV PSYCHOL, V24, P343, DOI 10.1037/0012-1649.24.3.343
   Martin A, 2003, COGN NEUROPSYCHOL, V20, P575, DOI 10.1080/02643290342000005
   Maylor EA, 2002, BRIT J PSYCHOL, V93, P465, DOI 10.1348/000712602761381358
   McKinnon MC, 2007, COGNITION, V102, P179, DOI 10.1016/j.cognition.2005.12.011
   Miller SA, 2009, PSYCHOL BULL, V135, P749, DOI 10.1037/a0016854
   Mitchell JP, 2002, P NATL ACAD SCI USA, V99, P15238, DOI 10.1073/pnas.232395699
   Moran JM, 2011, P NATL ACAD SCI USA, V108, P2688, DOI 10.1073/pnas.1011734108
   Moran JM, 2012, J NEUROSCI, V32, P5553, DOI 10.1523/JNEUROSCI.5511-11.2012
   Pardini M, 2009, EXP AGING RES, V35, P98, DOI 10.1080/03610730802545259
   Perner J, 1989, Child Dev, V60, P688
   Pezzuti L, 2011, LIFE SPAN DISABILITY, V14, P31
   Phillips L. H., 2002, J GERONTOL B-PSYCHOL, V57, P526
   Phillips LH, 2011, COGNITION, V120, P236, DOI 10.1016/j.cognition.2011.05.003
   Piaget J., 1932, MORAL JUDGMENT CHILD
   Pratt MW, 1996, PSYCHOL AGING, V11, P66, DOI 10.1037/0882-7974.11.1.66
   PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
   Rakoczy H, 2012, BRIT J PSYCHOL, V103, P58, DOI 10.1111/j.2044-8295.2011.02040.x
   Ruffman T, 2008, NEUROSCI BIOBEHAV R, V32, P863, DOI 10.1016/j.neubiorev.2008.01.001
   Saltzman J, 2000, J INT NEUROPSYCH SOC, V6, P781, DOI 10.1017/S1355617700677056
   Saxe R, 2003, NEUROIMAGE, V19, P1835, DOI 10.1016/S1053-8119(03)00230-1
   SHULTZ TR, 1986, CHILD DEV, V57, P177, DOI 10.1111/j.1467-8624.1986.tb00018.x
   Slessor G, 2007, PSYCHOL AGING, V22, P639, DOI 10.1037/0882-7974.22.3.639
   Stone VE, 2006, SOC NEUROSCI-UK, V1, P309, DOI 10.1080/17470910601029221
   Stroop JR, 1935, J EXP PSYCHOL, V18, P643, DOI 10.1037/h0054651
   Sullivan S, 2004, BRIT J PSYCHOL, V95, P1, DOI 10.1348/000712604322779424
   Thompson-Schill SL, 1997, P NATL ACAD SCI USA, V94, P14792, DOI 10.1073/pnas.94.26.14792
   Uekermann J, 2006, J INT NEUROPSYCH SOC, V12, P184, DOI 10.1017/S1355617706060280
   Wang YF, 2006, PSYCHOLOGIA, V49, P228, DOI 10.2117/psysoc.2006.228
   WELLMAN HM, 1990, COGNITION, V35, P245, DOI 10.1016/0010-0277(90)90024-E
   WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5
   Young L, 2007, P NATL ACAD SCI USA, V104, P8235, DOI 10.1073/pnas.0701408104
   Young L, 2010, NEURON, V65, P845, DOI 10.1016/j.neuron.2010.03.003
   Zaitchik D, 2006, NEUROPSYCHOLOGY, V20, P11, DOI 10.1037/0894-4105.20.1.11
   ZAITCHIK D, 1990, COGNITION, V35, P41, DOI 10.1016/0010-0277(90)90036-J
   Zaitchik Deborah, 2004, Cogn Neuropsychiatry, V9, P301, DOI 10.1080/13546800344000246
   Zalla T, 2011, COGNITION, V121, P115, DOI 10.1016/j.cognition.2011.06.004
NR 74
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JAN 15
PY 2013
VL 237
BP 32
EP 40
DI 10.1016/j.bbr.2012.09.020
PG 9
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 051IG
UT WOS:000312119200005
PM 23000532
ER

PT J
AU Fairless, AH
   Katz, JM
   Vijayvargiya, N
   Dow, HC
   Kreibich, AS
   Berrettini, WH
   Abel, T
   Brodkin, ES
AF Fairless, Andrew H.
   Katz, Julia M.
   Vijayvargiya, Neha
   Dow, Holly C.
   Kreibich, Arati Sadalge
   Berrettini, Wade H.
   Abel, Ted
   Brodkin, Edward S.
TI Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Mouse; Social; Behavior; Development; Genetic; Environment
ID AUTISTIC-LIKE BEHAVIORS; INBRED MOUSE STRAINS; FRAGILE-X-SYNDROME;
   BTBR-T+TF/J MICE; ULTRASONIC COMMUNICATION; REPETITIVE BEHAVIOR;
   CORPUS-CALLOSUM; ADOLESCENT MICE; KNOCKOUT MICE; MODEL
AB BALB/cJ and C57BL/6J inbred mouse strains have been proposed as useful models of low and high levels of sociability (tendency to seek social interaction), respectively, based primarily on behaviors of similar to 30-day-old mice in the Social Approach Test (SAT). In the SAT, approach and sniffing behaviors of a test mouse toward an unfamiliar stimulus mouse are measured in a novel environment. However, it is unclear whether such results generalize to a familiar environment with a familiar social partner, such as with a littermate in a home cage environment. We hypothesized that C57BL/6J mice would show higher levels of social behaviors than BALB/cJ mice in the home cage environment, particularly at 30 days-of-age. We measured active and passive social behaviors in home cages by pairs of BALB/cJ or C57BL/6J littermates at ages 30, 41, and 69 days. The strains did not differ robustly in their active social behaviors. C57BL/6J mice were more passively social than BALB/cJ mice at 30 days, and C57BL/6J levels of passive social behaviors declined to BALB/cJ levels by 69 days. The differences in passive social behaviors at 30 days-of-age were primarily attributable to differences in huddling. These results indicate that different test conditions (SAT conditions vs. home cage conditions) elicit strain differences in distinct types of behaviors (approach/sniffing vs. huddling behaviors, respectively). Assessment of the more naturalistic social interactions in the familiar home cage environment with a familiar littermate will provide a useful component of a comprehensive assessment of social behaviors in mouse models relevant to autism. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Fairless, Andrew H.; Katz, Julia M.; Vijayvargiya, Neha; Dow, Holly C.; Kreibich, Arati Sadalge; Berrettini, Wade H.; Brodkin, Edward S.] Univ Penn, Ctr Neurobiol & Behav, Perelman Sch Med, Dept Psychiat,Translat Res Lab, Philadelphia, PA 19104 USA.
   [Abel, Ted] Univ Penn, Dept Biol, Lynch Lab 204G, Philadelphia, PA 19104 USA.
RP Brodkin, ES (reprint author), Univ Penn, Ctr Neurobiol & Behav, Perelman Sch Med, Dept Psychiat,Translat Res Lab, 125 S 31st St,Room 2220, Philadelphia, PA 19104 USA.
EM ebrodkin@mail.med.upenn.edu
FU National Institutes of Health [R01MH080718]; ARRA [3R01MH080718-03S1];
   Pennsylvania Department of Health (SAP) [4100043366]; Burroughs Wellcome
   Fund Career Award in the Biomedical Sciences;  [5-T32-MH017168]
FX This work was supported by National Institutes of Health Grants
   R01MH080718 (E.S.B.), ARRA supplement 3R01MH080718-03S1 (E.S.B.),
   5-T32-MH017168 (T.A., training grant supporting A.H.F.), Pennsylvania
   Department of Health (SAP# 4100043366), Burroughs Wellcome Fund Career
   Award in the Biomedical Sciences (E.S.B.). We thank Professors Tracy L.
   Bale, Julie A. Blendy, and Steven A. Thomas for their advice on the
   project. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institute of Mental Health or the National Institutes of Health. The
   Pennsylvania Department of Health specifically disclaims responsibility
   for any analyses, interpretations, or conclusions.
CR Bates D., 2010, IME4 LINEAR MIXED EF
   Blundell J, 2009, GENES BRAIN BEHAV, V8, P114, DOI 10.1111/j.1601-183X.2008.00455.x
   Blundell J, 2010, J NEUROSCI, V30, P2115, DOI 10.1523/JNEUROSCI.4517-09.2010
   Brodkin ES, 2004, BRAIN RES, V1002, P151, DOI 10.1016/j.brainres.2003.12.013
   Carter MD, 2011, AUTISM RES, V4, P57, DOI 10.1002/aur.180
   Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   Corbett BA, 2009, AUTISM RES, V2, P39, DOI 10.1002/aur.64
   Crawley JN, 2007, NEUROPEPTIDES, V41, P145, DOI 10.1016/j.npep.2007.02.002
   Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039
   Curley JP, 2010, BEHAV GENET, V40, P220, DOI 10.1007/s10519-010-9334-4
   Dahlhaus R, 2010, BEHAV BRAIN RES, V208, P96, DOI 10.1016/j.bbr.2009.11.019
   de Visser L, 2006, Genes Brain Behav, V5, P458, DOI 10.1111/j.1601-183X.2005.00181.x
   Defensor EB, 2011, BEHAV BRAIN RES, V217, P302, DOI 10.1016/j.bbr.2010.10.033
   Deutsch SI, 2011, BRAIN RES BULL, V84, P8, DOI 10.1016/j.brainresbull.2010.10.006
   Dissanayake C, 1997, J AUTISM DEV DISORD, V27, P295, DOI 10.1023/A:1025802515241
   Ehninger D, 2010, MOL PSYCHIAT
   Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106
   Fairless AH, 2008, BRAIN RES, V1230, P211, DOI 10.1016/j.brainres.2008.07.025
   Fairless AH, 2011, ANAT REC, V294, P1713, DOI 10.1002/ar.21318
   Gomot M, 2011, INT J PSYCHOPHYSIOLO
   Hamilton SM, 2011, BEHAV BRAIN RES, V218, P29, DOI 10.1016/j.bbr.2010.11.026
   Jacome LF, 2011, BRAIN RES BULL, V84, P12, DOI 10.1016/j.brainresbull.2010.10.010
   Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
   Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
   Kalueff AV, 2006, BEHAV PROCESS, V71, P8, DOI 10.1016/j.beproc.2005.09.004
   Knott F, 2007, J AUTISM DEV DISORD, V37, P1987, DOI 10.1007/s10803-006-0347-z
   Kumar M, BRAIN RES IN PRESS
   Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Fairless AH, 2012, BEHAV BRAIN RES, V228, P299, DOI [10.1016/j.bbr.2011.12.001, 10.1016/j.bbr.2.011.12.001]
   Liu ZH, 2009, NEUROSCI LETT, V454, P62, DOI 10.1016/j.neulet.2009.02.066
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   McNaughton CH, 2008, BEHAV NEUROSCI, V122, P293, DOI [10.1037/0735-7044.122.2.293, 10.1037/0735-7044A22.2.293]
   MITLER MM, 1977, BRAIN RES, V131, P129, DOI 10.1016/0006-8993(77)90033-6
   MONDRAGON R, 1987, BEHAV NEURAL BIOL, V47, P384, DOI 10.1016/S0163-1047(87)90500-0
   Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x
   Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
   Mundy P, 2010, AUTISM, V14, P408, DOI 10.1177/1362361310366315
   Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x
   Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Page DT, 2009, P NATL ACAD SCI USA, V106, P1989, DOI 10.1073/pnas.0804428106
   Panksepp JB, 2007, GENES BRAIN BEHAV, V6, P661, DOI 10.1111/j.1601-183X.2006.00295.x
   Panksepp JB, 2008, BEHAV BRAIN RES, V195, P239, DOI 10.1016/j.bbr.2008.09.010
   Panksepp JB, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000351
   Pearson BL, 2010, BEHAV BRAIN RES, V213, P189, DOI 10.1016/j.bbr.2010.04.054
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Pietropaolo Susanna, 2011, PLoS One, V6, pe17073, DOI 10.1371/journal.pone.0017073
   Pobbe RL, 2010, BEHAV BRAIN RES
   R Development Core Team, 2010, R LANG ENV STAT COMP
   Rutgers AH, 2004, J CHILD PSYCHOL PSYC, V45, P1123, DOI 10.1111/j.1469-7610.2004.t01-1-00305.x
   Ryan BC, 2010, BEHAV BRAIN RES, V208, P178, DOI 10.1016/j.bbr.2009.11.031
   Sala M, 2011, BIOL PSYCHIAT, V69, P875, DOI 10.1016/j.biopsych.2010.12.022
   Sankoorikal GMV, 2006, BIOL PSYCHIAT, V59, P415, DOI 10.1016/j.biopsych.2005.07.026
   Sarna JR, 2000, BEHAV BRAIN RES, V108, P39, DOI 10.1016/S0166-4328(99)00137-0
   Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201
   Smit-Rigter LA, 2010, FRONT BEHAV NEUROSCI, V4, DOI 10.3389/fnbeh.2010.00169
   Southwick C. H., 1968, Communications in Behavioral Biology, VA1, P49
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   TERRANOVA ML, 1993, DEV PSYCHOBIOL, V26, P467, DOI 10.1002/dev.420260805
   Wilcox RR, 2005, INTRO ROBUST ESTIMAT
   Yang M, 2009, EUR J NEUROSCI, V29, P1663, DOI 10.1111/j.1460-9568.2009.06714.x
   Yang M, 2007, INT J DEV NEUROSCI, V25, P515, DOI 10.1016/j.ijdevneu.2007.09.008
NR 66
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JAN 15
PY 2013
VL 237
BP 338
EP 347
DI 10.1016/j.bbr.2012.08.051
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 051IG
UT WOS:000312119200047
PM 22982070
ER

PT J
AU Lang, M
   Wither, RG
   Brotchie, JM
   Wu, CP
   Zhang, L
   Eubanks, JH
AF Lang, Min
   Wither, Robert G.
   Brotchie, Jonathan M.
   Wu, Chiping
   Zhang, Liang
   Eubanks, James H.
TI Selective preservation of MeCP2 in catecholaminergic cells is sufficient
   to improve the behavioral phenotype of male and female Mecp2-deficient
   mice
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID CPG-BINDING PROTEIN-2; RETT-SYNDROME; MOUSE MODEL; SUBSTANTIA-NIGRA;
   LIFE-SPAN; NEURONS; AUTISM; BRAIN; NOREPINEPHRINE; DEFICIENCY
AB Rett syndrome (RTT) is a neurodevelopmental disorder caused primarily by mutations of the X-linked MECP2 gene. Although the loss of MeCP2 function affects many neural systems, impairments of catecholaminergic function have been hypothesized to underlie several of the cardinal behavioral deficits of RTT patients and Mecp2-deficient mice. Although recent Mecp2 reactivation studies indicate that RTT may be a reversible condition, it remains unclear whether specifically preserving Mecp2 function within a specific system will be sufficient to convey beneficial effects. Here, we test whether the selective preservation of Mecp2 within catecholaminergic cells will improve the phenotype of Mecp2-deficient mice. Our results show that this targeted preservation of Mecp2 significantly improves the lifespan, phenotypic severity and cortical epileptiform discharge activity of both male and female Mecp2-deficient mice. Further, we found that the catecholaminergic preservation of Mecp2 also improves the ambulatory rate, rearing activity, motor coordination, anxiety and nest-building performances of Mecp2-deficient mice of each gender. Interestingly, our results also revealed a gender-specific improvement, as specific cortical and hippocampal electroencephalographic abnormalities were significantly improved in male, but not female, rescue mice. Collectively, these results support the role of the catecholaminergic system in the pathogenesis of RTT and provide proof-of-principle that restoring MeCP2 function within this specific system could represent a treatment strategy for RTT.
C1 [Lang, Min; Wither, Robert G.; Eubanks, James H.] Univ Hlth Network, Toronto Western Res Inst, Div Genet & Dev, Toronto, ON M5T 2S8, Canada.
   [Brotchie, Jonathan M.] Univ Hlth Network, Toronto Western Res Inst, Div Brain Imaging & Behav, Toronto, ON M5T 2S8, Canada.
   [Wu, Chiping; Zhang, Liang] Univ Hlth Network, Toronto Western Res Inst, Div Fundamental Neurosci, Toronto, ON M5T 2S8, Canada.
   [Lang, Min; Wither, Robert G.; Wu, Chiping; Zhang, Liang; Eubanks, James H.] Univ Toronto, Epilepsy Res Program, Toronto, ON M5S 1A8, Canada.
   [Zhang, Liang] Univ Toronto, Dept Neurol, Toronto, ON M5S 1A8, Canada.
   [Eubanks, James H.] Univ Toronto, Dept Surg Neurosurg, Toronto, ON M5S 1A8, Canada.
RP Eubanks, JH (reprint author), Univ Hlth Network, Toronto Western Res Inst, Div Genet & Dev, Mac 13-423,399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM jeubanks@uhnres.utoronto.ca
FU Canadian Institutes of Health Research [MOP-106481]; International Rett
   Syndrome Foundation [IRSF-2475]
FX This work was supported by the Canadian Institutes of Health Research
   (MOP-106481 to J.H.E.) and the International Rett Syndrome Foundation
   (IRSF-2475 to J.H.E. and L.Z.). M. L. was a recipient of a University of
   Toronto Entry Fellowship.
CR Alvarez-Saavedra M, 2007, HUM MOL GENET, V16, P2315, DOI 10.1093/hmg/ddm185
   Amir RE, 1999, NAT GENET, V23, P185
   Armstrong DD, 1998, J NEUROPATH EXP NEUR, V57, P1013, DOI 10.1097/00005072-199811000-00003
   Armstrong DD, 2002, MENT RETARD DEV D R, V8, P72, DOI 10.1002/mrdd.10027
   Belichenko PV, 2009, J COMP NEUROL, V514, P240, DOI 10.1002/cne.22009
   BELICHENKO PV, 1994, NEUROREPORT, V5, P1509, DOI 10.1097/00001756-199407000-00025
   Berger B, 1985, Brain Res, V355, P141
   Bjorklund A, 2007, TRENDS NEUROSCI, V30, P194, DOI 10.1016/j.tins.2007.03.006
   BRUHWYLER J, 1991, PHARMACOL BIOCHEM BE, V39, P367, DOI 10.1016/0091-3057(91)90193-6
   Chahrour M, 2007, NEURON, V56, P422, DOI 10.1016/j.neuron.2007.10.001
   Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906
   Cheval H, 2012, HUM MOL GENET, V21, P3806, DOI 10.1093/hmg/dds208
   D'Cruz JA, 2010, NEUROBIOL DIS, V38, P8, DOI 10.1016/j.nbd.2009.12.018
   Gantz SC, 2011, J NEUROSCI, V31, P12629, DOI 10.1523/JNEUROSCI.0684-11.2011
   Giacometti E, 2007, P NATL ACAD SCI USA, V104, P1931, DOI 10.1073/pnas.0610593104
   Glaze DG, 2004, MENT RETARD DEV D R, V10, P154, DOI 10.1002/mrdd.20030
   Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899
   Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
   HAGBERG B, 1983, ANN NEUROL, V14, P471, DOI 10.1002/ana.410140412
   HOKFELT T, 1984, SCIENCE, V225, P1326, DOI 10.1126/science.6147896
   Jellinger K, 1986, Am J Med Genet Suppl, V1, P259
   Johnston MV, 2001, BRAIN DEV-JPN, V23, pS206, DOI 10.1016/S0387-7604(01)00351-5
   Jugloff DGM, 2008, HUM MOL GENET, V17, P1386, DOI 10.1093/hmg/ddn026
   Julu POO, 1997, EUR CHILD ADOLES PSY, V6, P47
   Leontovich TA, 1999, NEUROBIOL DIS, V6, P77, DOI 10.1006/nbdi.1998.0234
   Liao WL, 2012, NEUROBIOL DIS, V46, P88, DOI 10.1016/j.nbd.2011.12.048
   Lioy DT, 2011, NATURE, V475, P497, DOI 10.1038/nature10214
   Morilak DA, 2005, PROG NEURO-PSYCHOPH, V29, P1214, DOI 10.1016/j.pnpbp.2005.08.007
   Mount RH, 2002, J INTELL DISABIL RES, V46, P619, DOI 10.1046/j.1365-2788.2002.00442.x
   NOMURA Y, 1985, BRAIN DEV-JPN, V7, P334
   Panayotis N, 2011, NEUROBIOL DIS, V41, P385, DOI 10.1016/j.nbd.2010.10.006
   Percy AK, 2011, ARCH NEUROL-CHICAGO, V68, P985, DOI 10.1001/archneurol.2011.149
   Percy AK, 2002, NEUROL CLIN, V20, P1125, DOI 10.1016/S0733-8619(02)00022-1
   Robinson L., 2012, BRAIN, V5, P5
   Roux JC, 2010, BEHAV GENET, V40, P59, DOI 10.1007/s10519-009-9303-y
   Roux JC, 2007, EUR J NEUROSCI, V25, P1915, DOI 10.1111/j.1460-9568.2007.05466.x
   Samaco RC, 2009, P NATL ACAD SCI USA, V106, P21966, DOI 10.1073/pnas.0912257106
   Savitt JM, 2005, J NEUROSCI, V25, P6721, DOI 10.1523/JNEUROSCI.0760-05.2005
   Segawa M, 1997, EUR CHILD ADOLES PSY, V6, P56
   Shiotsuki H, 2010, J NEUROSCI METH, V189, P180, DOI 10.1016/j.jneumeth.2010.03.026
   Stearns NA, 2007, NEUROSCIENCE, V146, P907, DOI 10.1016/j.neuroscience.2007.02.009
   Szczypka MS, 2001, NEURON, V30, P819, DOI 10.1016/S0896-6273(01)00319-1
   Taneja P, 2009, J NEUROSCI, V29, P12187, DOI 10.1523/JNEUROSCI.3156-09.2009
   Thomas SA, 1997, CELL, V91, P583, DOI 10.1016/S0092-8674(00)80446-8
   TORDA C, 1976, J NEUROSCI RES, V2, P193, DOI 10.1002/jnr.490020303
   Truett GE, 2000, BIOTECHNIQUES, V29, P52
   Verney C, 1982, Brain Res, V281, P41
   Viemari JC, 2005, J NEUROSCI, V25, P11521, DOI 10.1523/JNEUROSCI.4373-05.2005
   Ward CS, 2011, J NEUROSCI, V31, P10359, DOI 10.1523/JNEUROSCI.0057-11.2011
   Wither RG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035396
   Wu C, 2008, J NEUROSCI METH, V171, P126, DOI 10.1016/j.jneumeth.2008.03.001
   Zanella S, 2008, RESP PHYSIOL NEUROBI, V160, P116, DOI 10.1016/j.resp.2007.08.009
   ZOGHBI HY, 1989, ANN NEUROL, V25, P56, DOI 10.1002/ana.410250109
NR 53
TC 9
Z9 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD JAN 15
PY 2013
VL 22
IS 2
BP 358
EP 371
DI 10.1093/hmg/dds433
PG 14
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 058RP
UT WOS:000312651800013
PM 23077217
ER

PT J
AU Matsunami, N
   Hadley, D
   Hensel, CH
   Christensen, GB
   Kim, C
   Frackelton, E
   Thomas, K
   da Silva, RP
   Stevens, J
   Baird, L
   Otterud, B
   Ho, K
   Varvil, T
   Leppert, T
   Lambert, CG
   Leppert, M
   Hakonarson, H
AF Matsunami, Nori
   Hadley, Dexter
   Hensel, Charles H.
   Christensen, G. Bryce
   Kim, Cecilia
   Frackelton, Edward
   Thomas, Kelly
   da Silva, Renata Pellegrino
   Stevens, Jeff
   Baird, Lisa
   Otterud, Brith
   Ho, Karen
   Varvil, Tena
   Leppert, Tami
   Lambert, Christophe G.
   Leppert, Mark
   Hakonarson, Hakon
TI Identification of Rare Recurrent Copy Number Variants in High-Risk
   Autism Families and Their Prevalence in a Large ASD Population
SO PLOS ONE
LA English
DT Article
ID SPECTRUM DISORDERS; DE-NOVO; CHROMOSOMAL REARRANGEMENTS;
   MENTAL-RETARDATION; HIGH-FREQUENCY; TWIN PAIRS; GENES; LINKAGE;
   SCHIZOPHRENIA; LOCI
AB Structural variation is thought to play a major etiological role in the development of autism spectrum disorders (ASDs), and numerous studies documenting the relevance of copy number variants (CNVs) in ASD have been published since 2006. To determine if large ASD families harbor high-impact CNVs that may have broader impact in the general ASD population, we used the Affymetrix genome-wide human SNP array 6.0 to identify 153 putative autism-specific CNVs present in 55 individuals with ASD from 9 multiplex ASD pedigrees. To evaluate the actual prevalence of these CNVs as well as 185 CNVs reportedly associated with ASD from published studies many of which are insufficiently powered, we designed a custom Illumina array and used it to interrogate these CNVs in 3,000 ASD cases and 6,000 controls. Additional single nucleotide variants (SNVs) on the array identified 25 CNVs that we did not detect in our family studies at the standard SNP array resolution. After molecular validation, our results demonstrated that 15 CNVs identified in high-risk ASD families also were found in two or more ASD cases with odds ratios greater than 2.0, strengthening their support as ASD risk variants. In addition, of the 25 CNVs identified using SNV probes on our custom array, 9 also had odds ratios greater than 2.0, suggesting that these CNVs also are ASD risk variants. Eighteen of the validated CNVs have not been reported previously in individuals with ASD and three have only been observed once. Finally, we confirmed the association of 31 of 185 published ASD-associated CNVs in our dataset with odds ratios greater than 2.0, suggesting they may be of clinical relevance in the evaluation of children with ASDs. Taken together, these data provide strong support for the existence and application of high-impact CNVs in the clinical genetic evaluation of children with ASD.
C1 [Matsunami, Nori; Stevens, Jeff; Baird, Lisa; Otterud, Brith; Varvil, Tena; Leppert, Tami; Leppert, Mark] Univ Utah, Dept Human Genet, Salt Lake City, UT USA.
   [Hadley, Dexter; Kim, Cecilia; Frackelton, Edward; Thomas, Kelly; da Silva, Renata Pellegrino; Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
   [Hensel, Charles H.; Ho, Karen] Lineagen Inc, Salt Lake City, UT USA.
   [Christensen, G. Bryce; Lambert, Christophe G.] Golden Helix Inc, Bozeman, MT USA.
   [Hakonarson, Hakon] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.
RP Hakonarson, H (reprint author), Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.
EM hakonarson@email.chop.edu
FU National Institute of Mental Health [1U24MH081810]; Margaret Q.
   Landenberger Foundation; Lineagen, Inc.
FX All Utah subjects were ascertained and DNA collected with support from
   R01 MH 06359 from the National Institute of Mental Health and
   U19HD035476 from the National Institute of Child Health and Human
   Development. DNA was processed with support from GCRC M01-RR025764 from
   the National Center for Research Resources. The Autism Genetic Resource
   Exchange is a program of Autism Speaks and is supported, in part, by
   grant 1U24MH081810 from the National Institute of Mental Health to Clara
   M. Lajonchere (PI). Dr. Hakonaron is additionally supported by the
   Margaret Q. Landenberger Foundation. Additional funding for this study
   was provided by Lineagen, Inc. Scientific input into study design, data
   analysis, and preparation of the manuscript were provided by two authors
   who are Lineagen employees (CHH, KH). The remaining funders had no role
   in study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Bergboer JGM, 2012, J INVEST DERMATOL
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Biswas AK, 2012, CANCER RES, V72, P13, DOI 10.1158/0008-5472.CAN-11-2196
   Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
   Buxbaum JD, 2004, MOL PSYCHIATR, V9, P144, DOI 10.1038/sj.mp.4001465
   Camacho-Garcia RJ, 2012, NEUROBIOL DIS, V47, P135, DOI 10.1016/j.nbd.2012.03.031
   Carrie A, 1999, NAT GENET, V23, P25
   Ching MSL, 2010, AM J MED GENET B, V153B, P937, DOI 10.1002/ajmg.b.31063
   Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
   Cook EH, 1997, AM J HUM GENET, V60, P928
   Davis LK, 2009, J NEURODEV DISORD, V1, P292, DOI 10.1007/s11689-009-9013-z
   Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017
   Fernandez BA, 2010, J MED GENET, V47, P195, DOI 10.1136/jmg.2009.069369
   Gambino F, 2007, P NATL ACAD SCI USA, V104, P9063, DOI 10.1073/pnas.0701133104
   Girirajan S, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002334
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Grant SGN, 2012, CURR OPIN NEUROBIOL, V22, P522, DOI 10.1016/j.conb.2012.02.002
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Harrison V, 2011, AM J MED GENET A, V155A, P2826, DOI 10.1002/ajmg.a.34255
   Havik B, 2011, BIOL PSYCHIAT, V70, P35, DOI 10.1016/j.biopsych.2011.01.030
   Hedges DJ, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-2
   Hogart A, 2007, HUM MOL GENET, V16, P691, DOI 10.1093/hmg/ddm014
   Huang DW, 2008, NAT PROTOC, V4, P44, DOI DOI 10.1038/NPROT.2008.211
   Huang DW, 2009, NUCLEIC ACIDS RES, V37, P1, DOI 10.1093/nar/gkn923
   Bailey A, 1998, HUM MOL GENET, V7, P571
   Palferman S, 2001, AM J HUM GENET, V69, P570
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Jacquemont ML, 2006, J MED GENET, V43, P843, DOI 10.1136/jmg.2006.043166
   Kalia LV, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014695
   Kang JQ, 2013, J AUTISM DEV DISORD, V43, P68, DOI 10.1007/s10803-012-1543-7
   Kao WT, 2010, P NATL ACAD SCI USA, V107, P15619, DOI 10.1073/pnas.1005410107
   Kent WJ, 2002, GENOME RES, V12, P996, DOI 10.1101/gr.229102
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
   Kirov G, 2009, SCHIZOPHRENIA BULL, V35, P851, DOI 10.1093/schbul/sbp079
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Lionel AC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002464
   Manning M, 2010, GENET MED, V12, P742, DOI 10.1097/GIM.0b013e3181f8baad
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Martin Christa Lese, 2007, Curr Psychiatry Rep, V9, P141
   Michel M, 2012, DEV NEUROBIOL
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   Nunn C, 2006, SEMIN CELL DEV BIOL, V17, P390, DOI 10.1016/j.semcdb.2006.04.001
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Prescott SM, 2008, ANNU REV GENOM HUM G, V9, P347, DOI 10.1146/annurev.genom.9.081307.164441
   Price AL, 2006, NAT GENET, V38, P904, DOI 10.1038/ng1847
   Punia S, 2010, PHARMACOGENET GENOM, V20, P435, DOI 10.1097/FPC.0b013e32833ad3bb
   Qiao Y, 2009, J MED GENET, V46, P680, DOI 10.1136/jmg.2009.066795
   Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159
   Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
   Sahoo T, 2011, GENET MED, V13, P868, DOI 10.1097/GIM.0b013e3182217a06
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Schaaf CP, 2012, EUR J HUM GENET
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Shema E, 2011, MOL CELL, V42, P477, DOI 10.1016/j.molcel.2011.03.011
   Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
   Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
   Stone TW, 2012, FEBS J, V279, P1386, DOI 10.1111/j.1742-4658.2012.08487.x
   Sumioka A, 2003, BIOCHEM J, V374, P261, DOI 10.1042/BJ20030489
   Sun J, 2012, PSYCHIAT RES
   Swaminathan S, 2011, INT J ALZHEIMERS DIS, V10, DOI [10.4061/2011/729478, DOI 10.4061/2011/729478]
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Vilarino-Guell C, 2010, NEUROGENETICS, V11, P401, DOI 10.1007/s10048-010-0241-x
   Wang K, 2007, GENOME RES, V17, P1665, DOI 10.1101/gr.6861907
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Williams AL, 2011, J BIOL CHEM, V286, P14542, DOI 10.1074/jbc.M110.215624
   Wu YW, 2011, HUM GENET, V129, P611, DOI 10.1007/s00439-011-0955-3
   Xu L, 2011, BRIT J DERMATOL, V165, P882, DOI 10.1111/j.1365-2133.2011.10485.x
   Yalcin O, 2012, SEIZURE-EUR J EPILEP, V21, P79, DOI 10.1016/j.seizure.2011.12.002
   Yamamoto Y, 2010, J BIOL CHEM, V285, P40943, DOI 10.1074/jbc.M110.156893
NR 72
TC 13
Z9 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 14
PY 2013
VL 8
IS 1
AR e52239
DI 10.1371/journal.pone.0052239
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 087KE
UT WOS:000314759400013
PM 23341896
ER

PT J
AU Zurcher, NR
   Donnelly, N
   Rogier, O
   Russo, B
   Hippolyte, L
   Hadwin, J
   Lemonnier, E
   Hadjikhani, N
AF Zuercher, Nicole R.
   Donnelly, Nick
   Rogier, Ophelie
   Russo, Britt
   Hippolyte, Loyse
   Hadwin, Julie
   Lemonnier, Eric
   Hadjikhani, Nouchine
TI It's All in the Eyes: Subcortical and Cortical Activation during
   Grotesqueness Perception in Autism
SO PLOS ONE
LA English
DT Article
ID UPSIDE-DOWN FACES; SPECTRUM DISORDERS; THATCHER ILLUSION; FUNCTIONAL
   NEUROANATOMY; HUMAN BRAIN; FACIAL EXPRESSIONS; ASPERGER-SYNDROME;
   INVERTED FACES; FEARFUL FACES; CHILDREN
AB Atypical face processing plays a key role in social interaction difficulties encountered by individuals with autism. In the current fMRI study, the Thatcher illusion was used to investigate several aspects of face processing in 20 young adults with high-functioning autism spectrum disorder (ASD) and 20 matched neurotypical controls. "Thatcherized" stimuli were modified at either the eyes or the mouth and participants discriminated between pairs of faces while cued to attend to either of these features in upright and inverted orientation. Behavioral data confirmed sensitivity to the illusion and intact configural processing in ASD. Directing attention towards the eyes vs. the mouth in upright faces in ASD led to (1) improved discrimination accuracy; (2) increased activation in areas involved in social and emotional processing; (3) increased activation in subcortical face-processing areas. Our findings show that when explicitly cued to attend to the eyes, activation of cortical areas involved in face processing, including its social and emotional aspects, can be enhanced in autism. This suggests that impairments in face processing in autism may be caused by a deficit in social attention, and that giving specific cues to attend to the eye-region when performing behavioral therapies aimed at improving social skills may result in a better outcome.
C1 [Zuercher, Nicole R.; Rogier, Ophelie; Russo, Britt; Hippolyte, Loyse; Hadjikhani, Nouchine] Ecole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland.
   [Donnelly, Nick; Hadwin, Julie] Univ Southampton, Sch Psychol, Southampton, Hants, England.
   [Lemonnier, Eric] CHRU Brest Hop Bohars, Ctr Ressources Autisme Bretagne, Bohars, France.
   [Lemonnier, Eric] Univ Brest, CHRU Brest Hop Bohars, Bohars, France.
   [Hadjikhani, Nouchine] Harvard Univ, Sch Med, MGH HMS MIT A Martinos Ctr Biomed Imaging, Charlestown, MA USA.
RP Hadjikhani, N (reprint author), Ecole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland.
EM nouchine@nmr.mgh.harvard.edu
RI Hadjikhani, Nouchine/C-2018-2008; Centre d'imagerie Biomedicale,
   CIBM/B-5740-2012
OI Hadjikhani, Nouchine/0000-0003-4075-3106; 
FU Swiss National Science Foundation [PP00P3-130191]; Velux Stiftung;
   Centre d'Imagerie BioMedicale (CIBM) of the University of Lausanne
   (UNIL); Swiss Federal Institute of Technology Lausanne (EPFL);
   University of Geneva (UniGe); Centre Hospitalier Universitaire Vaudois
   (CHUV); Hopitaux Universitaires de Geneve (HUG); Leenaards Foundation;
   Jeantet Foundation
FX This work was supported by the Swiss National Science Foundation
   (PP00P3-130191 to NH) and by the Velux Stiftung; by the Centre
   d'Imagerie BioMedicale (CIBM) of the University of Lausanne (UNIL), the
   Swiss Federal Institute of Technology Lausanne (EPFL), the University of
   Geneva (UniGe), the Centre Hospitalier Universitaire Vaudois (CHUV), the
   Hopitaux Universitaires de Geneve (HUG) and the Leenaards and the
   Jeantet Foundations. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
CR (APA) APA, 2000, DIAGN STAT MAN MENT
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   BARTLETT JC, 1993, COGNITIVE PSYCHOL, V25, P281, DOI 10.1006/cogp.1993.1007
   Barton JJS, 2001, BRIT J PSYCHOL, V92, P527, DOI 10.1348/000712601162329
   Batki A, 2000, INFANT BEHAV DEV, V23, P223, DOI 10.1016/S0163-6383(01)00037-6
   Beckmann CF, 2003, NEUROIMAGE, V20, P1052, DOI 10.1016/S1053-8119(03)00435-X
   Birmingham E, 2008, VIS COGN, V16, P341, DOI 10.1080/13506280701434532
   Bouvier SE, 2006, CEREB CORTEX, V16, P183, DOI 10.1093/cercor/bhi096
   Brosch T, 2008, PSYCHOL SCI, V19, P362, DOI 10.1111/j.1467-9280.2008.02094.x
   Buckner RL, 2011, J NEUROPHYSIOL, V106, P2322, DOI 10.1152/jn.00339.2011
   Carbon CC, 2007, PERCEPTION, V36, P1635, DOI 10.1068/p5467
   Carbon CC, 2005, COGNITIVE BRAIN RES, V24, P544, DOI 10.1016/j.cogbrainres.2005.03.008
   Carbon CC, 2005, PERCEPTION, V34, P1117, DOI 10.1068/p5192
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   Cornes K, 2008, THESIS U SOUTHAMPTON
   Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   de Gelder BC, 2003, P NATL ACAD SCI USA, V100, P13105, DOI 10.1073/pnas.1735530100
   DIAMOND R, 1986, J EXP PSYCHOL GEN, V115, P107, DOI 10.1037/0096-3445.115.2.107
   Donnelly N, 2012, ATTEN PERCEPT PSYCHO, V74, P1475, DOI 10.3758/s13414-012-0330-z
   Donnelly N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023340
   Duvernoy H. M., 1999, HUMAN BRAIN SURFACE, V2nd
   Eimer M, 2000, COGNITIVE BRAIN RES, V10, P145, DOI 10.1016/S0926-6410(00)00038-0
   Elsabbagh M, 2009, BIOL PSYCHIAT, V65, P31, DOI 10.1016/j.biopsych.2008.09.034
   Fairhall SL, 2007, CEREB CORTEX, V17, P2400, DOI 10.1093/cercor/bhl148
   Frith U, 2003, PHILOS T R SOC B, V358, P459, DOI 10.1098/rstb.2002.1218
   Frith CD, 2012, ANNU REV PSYCHOL, V63, P287, DOI 10.1146/annurev-psych-120710-100449
   Grice SJ, 2005, CORTEX, V41, P342, DOI 10.1016/S0010-9452(08)70271-5
   Hadjikhani N, 2007, HUM BRAIN MAPP, V28, P441, DOI 10.1002/hbm.20283
   Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025
   Hadjikhani N, 2002, HUM BRAIN MAPP, V16, P176, DOI 10.1002/hbm.10043
   Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
   Haxby JV, 1999, NEURON, V22, P189, DOI 10.1016/S0896-6273(00)80690-X
   HILLIARD R D, 1973, Cortex, V9, P246
   Ishai A, 2005, BRAIN RES BULL, V67, P87, DOI 10.1016/j.brainresbull.2005.05.027
   Ishai A, 2008, NEUROIMAGE, V40, P415, DOI 10.1016/j.neuroimage.2007.10.040
   Itier RJ, 2004, CEREB CORTEX, V14, P132, DOI 10.1093/cercor/bhg111
   Jenkinson M, 2002, NEUROIMAGE, V17, P825, DOI 10.1006/nimg.2002.1132
   Johnson M, 2005, NAT NEUROSCI REV, V6, P2
   Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
   Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
   Kingstone A, 2004, BRAIN COGNITION, V55, P269, DOI 10.1016/j.bandc.2004.02.037
   Kliemann D, 2012, J NEUROSCI, V32, P9469, DOI 10.1523/JNEUROSCI.5294-11.2012
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Kylliainen A, 2006, EUR J NEUROSCI, V24, P2679, DOI 10.1111/j.1460-9568.2006.05132.x
   Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
   Lahaie A, 2006, NEUROPSYCHOLOGY, V20, P30, DOI 10.1037/0894-4105.20.1.30
   LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
   Lopez B, 2004, VIS COGN, V11, P673, DOI 10.1080/13506280344000437
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Maddock RJ, 1999, TRENDS NEUROSCI, V22, P310, DOI 10.1016/S0166-2236(98)01374-5
   Malcolm GL, 2004, PERCEPTION, V33, P1221, DOI 10.1068/p5372
   Maurer D, 2002, TRENDS COGN SCI, V6, P255, DOI 10.1016/S1364-6613(02)01903-4
   Meng M, 2012, P ROY SOC B-BIOL SCI, V279, P2052, DOI 10.1098/rspb.2011.1784
   Mestry N, 2012, NEUROPSYCHOLOGIA
   Mohanty A, 2009, J NEUROSCI, V29, P10563, DOI 10.1523/JNEUROSCI.1170-09.2009
   Morris JP, 2007, SOC COGN AFFECT NEUR, V2, P31, DOI 10.1093/scan/nsl023
   MORTON J, 1991, PSYCHOL REV, V98, P164, DOI 10.1037//0033-295X.98.2.164
   Nishimura M, 2008, VIS COGN, V16, P859, DOI 10.1080/13506280701538514
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   PERRETT DI, 1988, BEHAV BRAIN RES, V29, P245, DOI 10.1016/0166-4328(88)90029-0
   Phan KL, 2002, NEUROIMAGE, V16, P331, DOI 10.1006/nimg.2002.1087
   Pourtois G, 2004, CEREB CORTEX, V14, P619, DOI 10.1093/cercor/bhh023
   Raven J., 2003, MANUAL RAVENS PROGR
   Riby DM, 2009, Q J EXP PSYCHOL, V62, P189, DOI 10.1080/17470210701855629
   Ristic J, 2005, COGNITIVE BRAIN RES, V24, P715, DOI 10.1016/j.cogbrainres.2005.02.007
   Rossion Bruno, 2002, Behav Cogn Neurosci Rev, V1, P63, DOI 10.1177/1534582302001001004
   Rossion B, 2000, NEUROREPORT, V11, P69, DOI 10.1097/00001756-200001170-00014
   Rouse H, 2004, J CHILD PSYCHOL PSYC, V45, P1246, DOI 10.1111/j.1469-7610.2004.00317.x
   SCAPINELLO KF, 1970, PSYCHON SCI, V21, P329
   Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
   Senju A, 2005, NEUROPSYCHOLOGIA, V43, P1297, DOI 10.1016/j.neuropsychologia.2004.12.002
   Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009
   Smith SM, 2004, NEUROIMAGE, V23, pS208, DOI 10.1016/j.neuroimage.2004.07.051
   Smith SM, 2002, NEUROIMAGE, V17, P479, DOI 10.1006/nimg.2002.1040
   Sorger B, 2007, NEUROIMAGE, V35, P836, DOI 10.1016/j.neuroimage.2006.09.051
   Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925
   Sturzel F, 2000, PERCEPTION, V29, P937, DOI 10.1068/p2888
   Tamietto M, 2010, NAT REV NEUROSCI, V11, P697, DOI 10.1038/nrn2889
   THOMPSON P, 1980, PERCEPTION, V9, P483, DOI 10.1068/p090483
   VALENTINE T, 1988, BRIT J PSYCHOL, V79, P471
   Vlamings P.H., 2009, J VIS, V9, P11
   Vuilleumier P, 2003, NAT NEUROSCI, V6, P624, DOI 10.1038/nn1057
   Wechsler D., 2006, WECHSLER NONVERBAL S
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
   Winston JS, 2003, CURR BIOL, V13, P1824, DOI 10.1016/j.cub.2003.09.038
   Woolrich M, 2008, NEUROIMAGE, V41, P286, DOI 10.1016/j.neuroimage.2008.02.042
   Woolrich MW, 2009, NEUROIMAGE, V45, pS173, DOI 10.1016/j.neuroimage.2008.10.055
   Woolrich MW, 2004, NEUROIMAGE, V21, P1732, DOI 10.1016/j.neuroimage.2003.12.023
   Woolrich MW, 2001, NEUROIMAGE, V14, P1370, DOI 10.1006/nimg.2001.0931
   Worsley K.J., 2001, FUNCTIONAL MRI INTRO
   Yarbus A. L, 1967, EYE MOVEMENT VISION
   YIN RK, 1969, J EXP PSYCHOL, V81, P141, DOI 10.1037/h0027474
   Yovel G, 2004, NEURON, V44, P889, DOI 10.1016/j.neuron.2004.11.018
NR 99
TC 11
Z9 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 14
PY 2013
VL 8
IS 1
AR e54313
DI 10.1371/journal.pone.0054313
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 087KE
UT WOS:000314759400147
PM 23342130
ER

PT J
AU Catarino, A
   Andrade, A
   Churches, O
   Wagner, AP
   Baron-Cohen, S
   Ring, H
AF Catarino, Ana
   Andrade, Alexandre
   Churches, Owen
   Wagner, Adam P.
   Baron-Cohen, Simon
   Ring, Howard
TI Task- related functional connectivity in autism spectrum conditions: an
   EEG study using wavelet transform coherence
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum conditions; Interhemispheric coherence; Atypical
   connectivity; Wavelet transform coherence
ID FALSE DISCOVERY RATE; CORTICAL CONNECTIVITY; WHITE-MATTER; BRAIN
   CONNECTIVITY; FACE PERCEPTION; WORKING-MEMORY; TIME-COURSE; DISORDER;
   CHILDREN; UNDERCONNECTIVITY
AB Background: Autism Spectrum Conditions (ASC) are a set of pervasive neurodevelopmental conditions characterized by a wide range of lifelong signs and symptoms. Recent explanatory models of autism propose abnormal neural connectivity and are supported by studies showing decreased interhemispheric coherence in individuals with ASC. The first aim of this study was to test the hypothesis of reduced interhemispheric coherence in ASC, and secondly to investigate specific effects of task performance on interhemispheric coherence in ASC.
   Methods: We analyzed electroencephalography (EEG) data from 15 participants with ASC and 15 typical controls, using Wavelet Transform Coherence (WTC) to calculate interhemispheric coherence during face and chair matching tasks, for EEG frequencies from 5 to 40 Hz and during the first 400 ms post-stimulus onset.
   Results: Results demonstrate a reduction of interhemispheric coherence in the ASC group, relative to the control group, in both tasks and for all electrode pairs studied. For both tasks, group differences were generally observed after around 150 ms and at frequencies lower than 13 Hz. Regarding within-group task comparisons, while the control group presented differences in interhemispheric coherence between faces and chairs tasks at various electrode pairs (FT7-FT8, TP7-TP8, P7-P8), such differences were only seen for one electrode pair in the ASC group (T7-T8). No significant differences in EEG power spectra were observed between groups.
   Conclusions: Interhemispheric coherence is reduced in people with ASC, in a time and frequency specific manner, during visual perception and categorization of both social and inanimate stimuli and this reduction in coherence is widely dispersed across the brain.
   Results of within-group task comparisons may reflect an impairment in task differentiation in people with ASC relative to typically developing individuals.
   Overall, the results of this research support the value of WTC in examining the time-frequency microstructure of task-related interhemispheric EEG coherence in people with ASC.
C1 [Catarino, Ana; Wagner, Adam P.; Ring, Howard] Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge CB2 8AH, England.
   [Catarino, Ana; Andrade, Alexandre] Univ Lisbon, Fac Sci, Inst Biophys & Biomed Engn, P-1749016 Lisbon, Portugal.
   [Churches, Owen] Univ S Australia, Adelaide, SA 5001, Australia.
   [Wagner, Adam P.] Natl Inst Hlth Res NIHR Collaborat Leadership App, Peterborough, Cambs, England.
   [Baron-Cohen, Simon] Univ Cambridge, Autism Res Ctr, Dept Psychiat, Cambridge CB2 8AH, England.
   [Ring, Howard] Cambridgeshire & Peterborough NHS Fdn Trust, Fulbourn Hosp, Cambridge CB21 5EF, England.
RP Catarino, A (reprint author), Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Douglas House,18B Trumpington Rd, Cambridge CB2 8AH, England.
EM am.catarino@gmail.com
FU National Alliance for Autism Research (USA); Medical Research Council
   (MRC) UK; Fundacao para a Ciencia e Tecnologia (Foundation for Science
   and Technology), Portugal; Cambridge Australia Trust; National Institute
   for Health Research (NIHR); Collaborations for Leadership in Applied
   Health Research and Care (CLAHRC)
FX The authors would like to thank Dr Peter Watson for his contribution to
   the statistical analyses. This study was conducted in association with
   the NIHR Collaboration in Leadership in Applied Health Research and Care
   (CLAHRC) for Cambridgeshire and Peterborough NHS Foundation Trust. This
   study was supported by a grant to HR from the National Alliance for
   Autism Research (USA). SBC was supported by the Medical Research Council
   (MRC) UK and the Wellcome Trust during the period of this work. AC was
   supported by a grant from the Fundacao para a Ciencia e Tecnologia
   (Foundation for Science and Technology), Portugal. OC was supported by
   the Cambridge Australia Trust. APW and HR were supported by the National
   Institute for Health Research (NIHR) Collaborations for Leadership in
   Applied Health Research and Care (CLAHRC).
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4th
   Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190
   Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Barttfeld P, 2011, NEUROPSYCHOLOGIA, V49, P254, DOI 10.1016/j.neuropsychologia.2010.11.024
   Belmonte MK, 2004, MOL PSYCHIATR, V9, P646, DOI 10.1038/sj.mp.4001499
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289
   Bentin S, 1996, J COGNITIVE NEUROSCI, V8, P551, DOI 10.1162/jocn.1996.8.6.551
   Boger-Megiddo I, 2006, J AUTISM DEV DISORD, V36, P733, DOI 10.1007/s10803-006-0121-2
   Brock J, 2002, DEV PSYCHOPATHOL, V14, P209
   Broyd SJ, 2009, NEUROSCI BIOBEHAV R, V33, P279, DOI 10.1016/j.neubiorev.2008.09.002
   Buzsaki G, 2004, SCIENCE, V304, P1926, DOI 10.1126/science.1099745
   Casanova MF, 2009, PHILOS T R SOC B, V364, P1433, DOI 10.1098/rstb.2008.0331
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Catarino A, 2011, CLIN NEUROPHYSIOL, V122, P2375, DOI 10.1016/j.clinph.2011.05.004
   Chung MK, 2004, NEUROIMAGE, V23, P242, DOI 10.1016/j.neuroimage.2004.04.037
   Churches O, 2010, NEUROREPORT, V21, P399, DOI 10.1097/WNR.0b013e328334311b
   Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013
   Courchesne E, 2001, NEUROLOGY, V57, P245
   COURCHESNE E, 1993, AM J ROENTGENOL, V160, P387
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337
   Courchesne E, 2005, DEV PSYCHOPATHOL, V17, P577, DOI 10.1017/S0954579405050285
   Curran T, 2002, COGN AFFECT BEHAV NE, V2, P1, DOI 10.3758/CABN.2.1.1
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018
   Essl M, 1998, MED BIOL ENG COMPUT, V36, P399, DOI 10.1007/BF02523206
   FORMAN SD, 1995, MAGNET RESON MED, V33, P636, DOI 10.1002/mrm.1910330508
   Friston KJ, 2003, NEUROIMAGE, V19, P1273, DOI 10.1016/S1053-8119(03)00202-7
   FRITH U, 1989, BRIT J DISORD COMMUN, V24, P123
   Gastgeb HZ, 2006, CHILD DEV, V77, P1717, DOI 10.1111/j.1467-8624.2006.00969.x
   Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037
   Gidley Larson J. C., 2006, AUTISM NEUROLOGICAL, P231
   Grezes J, 2009, NEUROPSYCHOLOGIA, V47, P1816, DOI 10.1016/j.neuropsychologia.2009.02.021
   Grinsted A, CROSSWAVELET WAVELET
   Haueisen J, 2002, NEUROIMAGE, V15, P159, DOI 10.1006/nimg.2001.0962
   Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
   Hughes JR, 2007, EPILEPSY BEHAV, V11, P20, DOI 10.1016/j.yebeh.2007.03.010
   Ishai A, 2000, J COGNITIVE NEUROSCI, V12, P35, DOI 10.1162/089892900564055
   Isler JR, 2010, CLIN NEUROPHYSIOL, V121, P2035, DOI 10.1016/j.clinph.2010.05.004
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Klein A, 2006, IEEE T BIO-MED ENG, V53, P266, DOI 10.1109/TBME.2005.862535
   Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334
   Klem G H, 1999, Electroencephalogr Clin Neurophysiol Suppl, V52, P3
   Klinger L. G., 1995, LEARNING COGNITION A, P119
   Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054
   Lachaux JP, 2002, NEUROPHYSIOL CLIN, V32, P157, DOI 10.1016/S0987-7053(02)00301-5
   Lainhart JE, 1997, J AM ACAD CHILD PSY, V36, P282, DOI 10.1097/00004583-199702000-00019
   Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042
   Leveille C, 2010, AUTISM RES, V3, P280, DOI 10.1002/aur.155
   Leys C, 2010, J EXP SOC PSYCHOL, V46, P684, DOI 10.1016/j.jesp.2010.02.007
   Lieberman MD, 2009, SOC COGN AFFECT NEUR, V4, P423, DOI 10.1093/scan/nsp052
   Maraun D, 2007, PHYS REV E, V75, DOI 10.1103/PhysRevE.75.016707
   McDonald JH, 2009, HDB BIOL STAT
   Milne E, 2009, BIOL PSYCHIAT, V65, P22, DOI 10.1016/j.biopsych.2008.07.017
   Monk CS, 2010, J PSYCHIATR NEUROSCI, V35, P105, DOI 10.1503/jpn.090085
   Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012
   Neul JL, 2011, NAT MED, V17, P1353, DOI 10.1038/nm.2552
   Nunez P., 2006, ELECT FIELDS BRAIN N
   Nunez P. L, 2000, BEHAV BRAIN SCI, V23, P399, DOI 10.1017/s01 40525x00003253
   Nunez PL, 2000, BEHAV BRAIN SCI, V23, P371, DOI 10.1017/S0140525X00003253
   Nunez PL, 1999, CLIN NEUROPHYSIOL, V110, P469, DOI 10.1016/S1388-2457(98)00043-1
   Nunez PL, 1997, ELECTROEN CLIN NEURO, V103, P499, DOI 10.1016/S0013-4694(97)00066-7
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Owen AM, 2005, HUM BRAIN MAPP, V25, P46, DOI 10.1002/hbm.20131
   Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
   Raymaekers R, 2009, BRAIN RES, V1304, P113, DOI 10.1016/j.brainres.2009.09.068
   Rippon G, 2007, INT J PSYCHOPHYSIOL, V63, P164, DOI 10.1016/j.ijpsycho.2006.03.012
   Rousselet GA, 2007, NEUROIMAGE, V36, P843, DOI 10.1016/j.neuroimage.2007.02.052
   Russo N, 2010, AUTISM RES, V3, P253, DOI 10.1002/aur.152
   Sahyoun CP, 2010, NEUROPSYCHOLOGIA, V48, P86, DOI 10.1016/j.neuropsychologia.2009.08.013
   Samar VJ, 1999, BRAIN LANG, V66, P7, DOI 10.1006/brln.1998.2024
   SAWILOWSKY SS, 1990, REV EDUC RES, V60, P91
   Seger CA, 2010, NEUROIMAGE, V50, P644, DOI 10.1016/j.neuroimage.2009.11.083
   Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
   Soulieres I, 2007, J AUTISM DEV DISORD, V37, P481, DOI 10.1007/s10803-006-0172-4
   Srinivasan R, 2007, J NEUROSCI METH, V166, P41, DOI 10.1016/j.jneumeth.2007.06.026
   Sundaram SK, 2008, CEREB CORTEX, V18, P2659, DOI 10.1093/cercor/bhn031
   Tang YY, 2008, IEEE ENG MED BIO, P4114, DOI 10.1109/IEMBS.2008.4650114
   Torrence C, 1998, B AM METEOROL SOC, V79, P61, DOI 10.1175/1520-0477(1998)079<0061:APGTWA>2.0.CO;2
   Tsoneva Tsvetomira, 2011, Conf Proc IEEE Eng Med Biol Soc, V2011, P3828, DOI 10.1109/IEMBS.2011.6090952
   VanRullen R, 2001, J COGNITIVE NEUROSCI, V13, P454, DOI 10.1162/08989290152001880
   Vidal CN, 2006, BIOL PSYCHIAT, V60, P218, DOI 10.1016/j.biopsych.2005.11.011
   von Stein A, 2000, INT J PSYCHOPHYSIOL, V38, P301, DOI 10.1016/S0167-8760(00)00172-0
   Wass S, 2011, BRAIN COGNITION, V75, P18, DOI 10.1016/j.bandc.2010.10.005
   Wechsler D, 1999, WECHSLER ADULT INTEL
NR 87
TC 8
Z9 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD JAN 12
PY 2013
VL 4
AR 1
DI 10.1186/2040-2392-4-1
PG 14
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254TX
UT WOS:000327191500001
PM 23311570
ER

PT J
AU D'Angelo, E
   Casali, S
AF D'Angelo, Egidio
   Casali, Stefano
TI Seeking a unified framework for cerebellar function and dysfunction:
   from circuit operations to cognition
SO FRONTIERS IN NEURAL CIRCUITS
LA English
DT Review
DE cerebellum; cognition; motor control; timing; prediction; autism;
   schizophrenia; dyslexia
ID TRANSCRANIAL MAGNETIC STIMULATION; DORSOLATERAL PREFRONTAL CORTEX;
   VERBAL WORKING-MEMORY; CEREBRAL-BLOOD-FLOW;
   POSITRON-EMISSION-TOMOGRAPHY; MAJOR DEPRESSIVE DISORDER; CAUDAL
   FASTIGIAL NUCLEUS; IMAGINED HAND MOVEMENTS; MEDIAL FRONTAL-CORTEX;
   DEVELOPMENTAL DYSLEXIA
AB Following the fundamental recognition of its involvement in sensory-motor coordination and learning, the cerebellum is now also believed to take part in the processing of cognition and emotion. This hypothesis is recurrent in numerous papers reporting anatomical and functional observations, and it requires an explanation. We argue that a similar circuit structure in all cerebellar areas may carry out various operations using a common computational scheme. On the basis of a broad review of anatomical data, it is conceivable that the different roles of the cerebellum lie in the specific connectivity of the cerebellar modules, with motor, cognitive, and emotional functions (at least partially) segregated into different cerebro-cerebellar loops. We here develop a conceptual and operational framework based on multiple interconnected levels (a meta-levels hypothesis): from cellular/molecular to network mechanisms leading to generation of computational primitives, thence to high-level cognitive/emotional processing, and finally to the sphere of mental function and dysfunction. The main concept explored is that of intimate interplay between timing and learning (reminiscent of the "timing and learning machine" capabilities long attributed to the cerebellum), which reverberates from cellular to circuit mechanisms. Subsequently, integration within large-scale brain loops could generate the disparate cognitive/emotional and mental functions in which the cerebellum has been implicated. We propose, therefore, that the cerebellum operates as a general-purpose co-processor, whose effects depend on the specific brain centers to which individual modules are connected. Abnormal functioning in these loops could eventually contribute to the pathogenesis of major brain pathologies including not just ataxia but also dyslexia, autism, schizophrenia, and depression.
C1 [D'Angelo, Egidio; Casali, Stefano] Dept Brain & Behav Sci, I-27100 Pavia, Italy.
   [D'Angelo, Egidio] IRCCS C Mondino, Brain Connect Ctr, Pavia, Italy.
RP D'Angelo, E (reprint author), Dept Brain & Behav Sci, Via Forlanini 6, I-27100 Pavia, Italy.
EM dangelo@unipv.it; stefano.casali@unipv.it
FU European Union [CEREBNET FP7-ITN238686, REALNET FP7-ICT270434]; Italian
   Ministry of Health [RF-2008-1143418, RF-2009-1475845]
FX This work was supported by the European Union (CEREBNET FP7-ITN238686
   and REALNET FP7-ICT270434) and by the Italian Ministry of Health
   (RF-2008-1143418 and RF-2009-1475845) to Egidio D'Angelo.
CR Ackermann H, 1997, BRAIN LANG, V60, P323, DOI 10.1006/brln.1997.1826
   Addis DR, 2009, NEUROPSYCHOLOGIA, V47, P2222, DOI 10.1016/j.neuropsychologia.2008.10.026
   Ahissar E, 2000, NATURE, V406, P302, DOI 10.1038/35018568
   Alahyane N, 2008, CEREBELLUM, V7, P595, DOI 10.1007/s12311-008-0065-5
   ALBUS J S, 1971, Mathematical Biosciences, V10, P25, DOI 10.1016/0025-5564(71)90051-4
   Allen G, 1997, SCIENCE, V275, P1940, DOI 10.1126/science.275.5308.1940
   American Psychiatric Association [APA], 1994, DIAGN STAT MAN MENT, V4th
   Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884
   ANDERSSON G, 1978, EXP BRAIN RES, V32, P565
   Andreasen NC, 1996, P NATL ACAD SCI USA, V93, P9985, DOI 10.1073/pnas.93.18.9985
   Andreasen NC, 1998, SCHIZOPHRENIA BULL, V24, P203
   Apps R, 2005, NAT REV NEUROSCI, V6, P297, DOI 10.1038/nrn1646
   Apps R, 2009, NAT REV NEUROSCI, V10, P670, DOI 10.1038/nrn2698
   Argyropoulos GP, 2011, CEREBELLUM, V10, P540, DOI 10.1007/s12311-011-0269-y
   Arriada-Mendicoa N, 1999, REV NEUROLOGIA, V29, P1075
   BADDELEY A, 1984, J EXP PSYCHOL GEN, V113, P518, DOI 10.1037//0096-3445.113.4.518
   Balsters JH, 2008, NEUROIMAGE, V43, P388, DOI 10.1016/j.neuroimage.2008.07.010
   Bartolo P. D., 2011, CEREBELLUM, V10, P624
   Battaglia F, 2006, CLIN NEUROPHYSIOL, V117, P1009, DOI 10.1016/j.clinph.2006.01.008
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Bedny M, 2008, CEREB CORTEX, V18, P2574, DOI 10.1093/cercor/bhn018
   Beldarrain MG, 1997, EUR NEUROL, V37, P82
   Bell CC, 2008, ANNU REV NEUROSCI, V31, P1, DOI 10.1146/annurev.neuro.30.051606.094225
   Blackwood N, 2004, COGNITIVE BRAIN RES, V20, P46, DOI 10.1016/j.cogbrainres.2003.12.009
   Blakemore SJ, 2003, EXP BRAIN RES, V153, P239, DOI 10.1007/s00221-003-1597-z
   Blakemore SJ, 2001, NEUROREPORT, V12, P1879, DOI 10.1097/00001756-200107030-00023
   Blakemore SJ, 1999, NEUROIMAGE, V10, P448, DOI 10.1006/nimg.1999.0478
   Blakemore SJ, 1998, NAT NEUROSCI, V1, P635, DOI 10.1038/2870
   Blakemore SJ, 1998, J NEUROSCI, V18, P7511
   Boisgueheneuc F, 2006, BRAIN, V129, P3315, DOI 10.1093/brain/awl244
   Booth JR, 2007, BRAIN RES, V1133, P136, DOI 10.1016/j.brainres.2006.11.074
   Boso M, 2010, FUNCT NEUROL, V25, P15
   Bostan AC, 2010, NEUROPSYCHOL REV, V20, P261, DOI 10.1007/s11065-010-9143-9
   Bottmer C, 2005, PSYCHIAT RES-NEUROIM, V140, P239, DOI 10.1016/j.pscychresns.2005.02.011
   Bower JM, 2002, ANN NY ACAD SCI, V978, P135, DOI 10.1111/j.1749-6632.2002.tb07562.x
   Bower JM, 1997, PROG BRAIN RES, V114, P463
   Brighina F, 2006, NEUROSCI LETT, V397, P229, DOI 10.1016/j.neulet.2005.12.050
   Brunet E, 2000, NEUROIMAGE, V11, P157, DOI 10.1006/nimg.1999.0525
   Burguiere E, 2005, NAT NEUROSCI, V8, P1292, DOI 10.1038/nn1532
   Buzsaki G., 2006, RHYTHMS BRAIN
   Cerminara NL, 2010, J NEUROSCI, V30, P16065, DOI 10.1523/JNEUROSCI.4823-10.2010
   Churchland P., 1998, NEUROBIOLOGY MIND
   Churchland P. S., 1992, COMPUTATIONAL BRAIN
   Clower DM, 2001, J NEUROSCI, V21, P6283
   Clower DM, 2005, CEREB CORTEX, V15, P913, DOI 10.1093/cercor/bhh190
   Coghill RC, 1999, J NEUROPHYSIOL, V82, P1934
   Colnaghi S, 2010, FUNCT NEUROL, V25, P165
   Connor LT, 2006, NEUROPSYCHOLOGIA, V44, P171, DOI 10.1016/j.neuropsychologia.2005.05.019
   Cotterill RMJ, 2001, PROG NEUROBIOL, V64, P1, DOI 10.1016/S0301-0082(00)00058-7
   COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
   COURCHESNE E, 1994, NEUROLOGY, V44, P214
   Courchesne E, 1997, LEARN MEMORY, V4, P1, DOI 10.1101/lm.4.1.1
   Craik FIM, 1996, J EXP PSYCHOL GEN, V125, P159, DOI 10.1037/0096-3445.125.2.159
   Crespo-Facorro B, 1999, AM J PSYCHIAT, V156, P386
   Critchley H, 2000, HUM BRAIN MAPP, V9, P93, DOI 10.1002/(SICI)1097-0193(200002)9:2<93::AID-HBM4>3.0.CO;2-Z
   Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
   Cui S.-Z., 2000, NEUROREPORT, V11, P1
   D'Angelo E, 2011, J INTEGR NEUROSCI, V10, P317, DOI 10.1142/S0219635211002762
   D'Angelo E, 2010, FUNCT NEUROL, V25, P125
   D'Angelo E, 2009, NEUROSCIENCE, V162, P805, DOI 10.1016/j.neuroscience.2009.01.048
   D'Angelo E, 2011, BRAIN RES REV, V66, P5, DOI 10.1016/j.brainresrev.2010.10.002
   D'Angelo E, 2009, TRENDS NEUROSCI, V32, P30, DOI 10.1016/j.tins.2008.09.007
   D'Angelo E., 2010, BRAIN RES REV, V66, P5
   D'Angelo E, 2010, FRONT CELL NEUROSCI, V4, DOI 10.3389/fncel.2010.00131
   Dean P., 2004, BRAIN RES, V144, P61
   Debas K, 2010, P NATL ACAD SCI USA, V107, P17839, DOI 10.1073/pnas.1013176107
   Desmond JE, 2005, ANN NEUROL, V58, P553, DOI 10.1002/ana.20604
   Desmond JE, 1997, J NEUROSCI, V17, P9675
   De Zeeuw CI, 2011, NAT REV NEUROSCI, V12, P327, DOI 10.1038/nrn3011
   Diedrichsen J, 2010, TRENDS COGN SCI, V14, P31, DOI 10.1016/j.tics.2009.11.004
   DIENER HC, 1992, MOVEMENT DISORD, V7, P95, DOI 10.1002/mds.870070202
   Dieudonne S, 2000, J NEUROSCI, V20, P1837
   DOLAN RJ, 1993, J NEUROL NEUROSUR PS, V56, P1290, DOI 10.1136/jnnp.56.12.1290
   Doron KW, 2010, BRAIN RES, V1307, P63, DOI 10.1016/j.brainres.2009.10.029
   Douglas RJ, 2004, ANNU REV NEUROSCI, V27, P419, DOI 10.1146/annurev.neuro.27.070203.144152
   Doya K, 2000, CURR OPIN NEUROBIOL, V10, P732, DOI 10.1016/S0959-4388(00)00153-7
   Doyon J, 2003, NEUROPSYCHOLOGIA, V41, P252, DOI 10.1016/S0028-3932(02)00158-6
   Doyon J, 2002, P NATL ACAD SCI USA, V99, P1017, DOI 10.1073/pnas.022615199
   Doyon J, 1997, BRAIN COGNITION, V34, P218, DOI 10.1006/brcg.1997.0899
   Drepper J, 1999, BRAIN, V122, P87, DOI 10.1093/brain/122.1.87
   Dum RP, 2003, J NEUROPHYSIOL, V89, P634, DOI 10.1152/jn.00626.2002
   Eccles J.C., 1967, CEREBELLUM NEURAL MA
   Eckert MA, 2003, BRAIN, V126, P482, DOI 10.1093/brain/awg026
   Elston GN, 2002, PROG BRAIN RES, V136, P109
   Fales CL, 2008, BIOL PSYCHIAT, V63, P377, DOI 10.1016/j.biopsych.2007.06.012
   Fawcett A.J., 2004, ELECT J RES ED PSYCH, V2, P35
   Fink GR, 2000, NEUROLOGY, V54, P1324
   Fitzgerald PB, 2008, HUM BRAIN MAPP, V29, P683, DOI 10.1002/hbm.20426
   Flourens M.-J.-P., 1824, RECHERCHES EXPT PROP
   Foti F, 2010, CEREBELLUM, V9, P29, DOI 10.1007/s12311-009-0134-4
   Frings M, 2006, CEREBELLUM, V5, P206, DOI 10.1080/14734220600589251
   FRITH U, 1991, TRENDS NEUROSCI, V14, P433, DOI 10.1016/0166-2236(91)90041-R
   Frodl T., 2009, BIOL PSYCHIAT, V67, P161
   Fusar-Poli P, 2009, J PSYCHIATR NEUROSCI, V34, P418
   Gao ZY, 2012, NAT REV NEUROSCI, V13, P619, DOI 10.1038/nrn3312
   Garrard P, 2008, J NEUROL, V255, P398, DOI 10.1007/s00415-008-0680-6
   Gebhart AL, 2002, ANN NY ACAD SCI, V978, P318, DOI 10.1111/j.1749-6632.2002.tb07577.x
   Gerardin E, 2000, CEREB CORTEX, V10, P1093, DOI 10.1093/cercor/10.11.1093
   Ghajar J, 2009, NEUROSCIENTIST, V15, P232, DOI 10.1177/1073858408326429
   Goel V., 2004, COGNITION, V93, P109
   Goel V, 2000, NEUROIMAGE, V12, P504, DOI 10.1006/nimg.2000.0636
   Goel V, 2001, NEUROPSYCHOLOGIA, V39, P901, DOI 10.1016/S0028-3932(01)00024-0
   Goffart L, 2003, ANN NY ACAD SCI, V1004, P220, DOI 10.1196/annals.1303.019
   Gonul AS, 2004, PROG NEURO-PSYCHOPH, V28, P1015, DOI 10.1016/j.pnpbp.2004.05.036
   Gonzalez B, 2005, BEHAV NEUROSCI, V119, P622, DOI 10.1037/0735-7044.119.2.622
   Gottwald B, 2004, J NEUROL NEUROSUR PS, V75, P1524, DOI 10.1136/jnnp.2003.018093
   Grealy MA, 2011, NEUROPSYCHOLOGIA, V49, P271, DOI 10.1016/j.neuropsychologia.2010.09.031
   Grefkes C, 2004, NEUROIMAGE, V23, P1494, DOI 10.1016/j.neuroimage.2004.08.031
   Grefkes C, 2002, NEURON, V35, P173, DOI 10.1016/S0896-6273(02)00741-9
   Guerrasio L., 2009, J NEUROPHYSIOL, V103, P1988
   Guggisberg AG, 2008, FRONT HUM NEUROSCI, V1, DOI 10.3389/neuro.09.014.2007
   Habas C, 2009, J NEUROSCI, V29, P8586, DOI 10.1523/JNEUROSCI.1868-09.2009
   Habib M, 2000, BRAIN, V123, P2373, DOI 10.1093/brain/123.12.2373
   HAINES DE, 1990, J COMP NEUROL, V299, P106, DOI 10.1002/cne.902990108
   Hansel C, 2001, NAT NEUROSCI, V4, P467
   HASHIMOTO M, 1995, BRAIN, V118, P1185, DOI 10.1093/brain/118.5.1185
   HASHIMOTO T, 1995, J AUTISM DEV DISORD, V25, P1, DOI 10.1007/BF02178163
   He Y, 2004, LECT NOTES COMPUT SC, V3217, P907
   HEATH RG, 1974, EXP NEUROL, V45, P268, DOI 10.1016/0014-4886(74)90118-6
   HIER DB, 1978, ARCH NEUROL-CHICAGO, V35, P90
   Ishai A, 2000, NEURON, V28, P979, DOI 10.1016/S0896-6273(00)00168-9
   Ito M, 1984, CEREBELLUM NEURAL CO
   ITO M, 1993, TRENDS NEUROSCI, V16, P448, DOI 10.1016/0166-2236(93)90073-U
   Ito M, 2005, PROG BRAIN RES, V148, P95, DOI 10.1016/S0079-6123(04)48009-1
   Ito M, 2008, NAT REV NEUROSCI, V9, P304, DOI 10.1038/nrn2332
   Ivry R, 2000, HUM BRAIN MAPP, V9, P115, DOI 10.1002/(SICI)1097-0193(200003)9:3<115::AID-HBM1>3.0.CO;2-5
   Ivry R B, 1992, Curr Opin Neurobiol, V2, P212, DOI 10.1016/0959-4388(92)90015-D
   Ivry RB, 2002, ANN NY ACAD SCI, V978, P302, DOI 10.1111/j.1749-6632.2002.tb07576.x
   Ivry R B, 1989, J Cogn Neurosci, V1, P136, DOI 10.1162/jocn.1989.1.2.136
   Jackson PL, 2005, NEUROIMAGE, V24, P771, DOI 10.1016/j.neuroimage.2004.09.006
   Jacobson GA, 2008, TRENDS NEUROSCI, V31, P617, DOI 10.1016/j.tins.2008.09.005
   Johnson-Laird PN, 2001, TRENDS COGN SCI, V5, P434, DOI 10.1016/S1364-6613(00)01751-4
   JOHNSONLAIRD PN, 1980, COGNITIVE SCI, V4, P71, DOI 10.1207/s15516709cog0401_4
   Jorntell H, 2006, NEURON, V52, P227, DOI 10.1016/j.neuron.2006.09.032
   Justus T, 2005, BRAIN LANG, V95, P304, DOI 10.1016/j.bandl.2005.02.001
   Kelly RM, 2003, J NEUROSCI, V23, P8432
   Kim C. H., 2011, J PHYSL, V590, P273
   Klinke I, 2010, CEREBELLUM, V9, P433, DOI 10.1007/s12311-010-0183-8
   Koch G, 2009, PHILOS T R SOC B, V364, P1907, DOI 10.1098/rstb.2009.0018
   Koch G, 2009, NEUROLOGY, V73, P113, DOI 10.1212/WNL.0b013e3181ad5387
   Konarski JZ, 2005, J PSYCHIATR NEUROSCI, V30, P178
   Krienen FM, 2009, CEREB CORTEX, V19, P2485, DOI 10.1093/cercor/bhp135
   Kusunoki M, 2000, VISION RES, V40, P1459, DOI 10.1016/S0042-6989(99)00212-6
   Kyriakopoulos M, 2008, BIOL PSYCHIAT, V63, P519, DOI 10.1016/j.biopsych.2007.05.021
   Laine J, 1998, NEUROREPORT, V9, P2399, DOI 10.1097/00001756-199807130-00045
   Langdon R, 2001, COGNITIVE NEUROPSYCH, V6, P241
   LeBeau FEN, 2005, TRENDS NEUROSCI, V28, P552, DOI 10.1016/j.tins.2005.08.005
   Lefevre P, 1998, NEURAL NETWORKS, V11, P1175, DOI 10.1016/S0893-6080(98)00071-9
   Leggio MG, 2008, BRAIN, V131, P1332, DOI 10.1093/brain/awn040
   Leggio MG, 2000, J NEUROL NEUROSUR PS, V69, P102, DOI 10.1136/jnnp.69.1.102
   Leroi I, 2002, AM J PSYCHIAT, V159, P1306, DOI 10.1176/appi.ajp.159.8.1306
   Liu ZF, 2010, PSYCHIAT RES-NEUROIM, V182, P211, DOI 10.1016/j.pscychresns.2010.03.004
   Llinas R., 1998, BRAIN CLOSED SYSTEM
   Llinas RR, 2009, PHILOS T R SOC B, V364, P1301, DOI 10.1098/rstb.2008.0309
   Lotze M, 1999, J COGNITIVE NEUROSCI, V11, P491, DOI 10.1162/089892999563553
   Lubke J, 2007, BRAIN STRUCT FUNCT, V212, P3, DOI 10.1007/s00429-007-0144-2
   Luciani L, 1891, CERVELLETTO NUOVI ST
   Luft AR, 2005, CEREBELLUM, V4, P90, DOI 10.1080/14734220410019084
   Maddox WT, 2005, J COGNITIVE NEUROSCI, V17, P707, DOI 10.1162/0898929053747630
   Marien P, 1996, J NEUROL SCI, V144, P34, DOI 10.1016/S0022-510X(96)00059-7
   MARR D, 1969, J PHYSIOL-LONDON, V202, P437
   Matell MS, 2004, COGNITIVE BRAIN RES, V21, P139, DOI 10.1016/j.cogbrainres.2004.06.012
   Medina JF, 2000, NAT NEUROSCI, V3, P1205, DOI 10.1038/81486
   Mellet E, 2000, J COGNITIVE NEUROSCI, V12, P98, DOI 10.1162/08989290051137620
   Miall RC, 2002, BRAIN COGNITION, V48, P212, DOI 10.1006/brcg.2001.1314
   Middleton FA, 2001, J NEUROSCI, V21, P700
   Milad MR, 2002, NATURE, V420, P70, DOI 10.1038/nature01138
   Mills NP, 2005, AM J PSYCHIAT, V162, P1530, DOI 10.1176/appi.ajp.162.8.1530
   Moberget T, 2008, NEUROPSYCHOLOGIA, V46, P2569, DOI 10.1016/j.neuropsychologia.2008.03.016
   Molinari M, 2004, J NEUROL NEUROSUR PS, V75, P235
   Molinari M, 2002, NEUROSCIENCE, V111, P863, DOI 10.1016/S0306-4522(02)00024-6
   Monkul ES, 2008, PROG NEURO-PSYCHOPH, V32, P613, DOI [10.1016/j.pnpbp.2007.09.016, 10.1015/j.pnpbp.2007.09.016]
   MORGAN MA, 1993, NEUROSCI LETT, V163, P109, DOI 10.1016/0304-3940(93)90241-C
   Mugnaini E, 2011, BRAIN RES REV, V66, P220, DOI 10.1016/j.brainresrev.2010.10.001
   Nair DG, 2003, COGNITIVE BRAIN RES, V15, P250, DOI 10.1016/S0926-6410(02)00197-0
   Naito E, 2002, J NEUROSCI, V22, P3683
   Nicolson RI, 2001, TRENDS NEUROSCI, V24, P508, DOI 10.1016/S0166-2236(00)01896-8
   Nyberg L, 2010, P NATL ACAD SCI USA, V107, P22356, DOI 10.1073/pnas.1016823108
   Oberdick J, 2011, CEREBELLUM, V10, P301, DOI 10.1007/s12311-011-0306-x
   Ohtsuki G, 2009, FRONT CELL NEUROSCI, V3, DOI 10.3389/neuro.03.004.2009
   Oliveri M, 2005, NEUROSCI LETT, V376, P188, DOI 10.1016/j.neulet.2004.11.053
   Webster Brian R, 2006, NeuroRx, V3, P474, DOI 10.1016/j.nurx.2006.07.008
   Orban de Xivry JJ, 2007, J PHYSL, V584, P11
   O'Reilly JX, 2008, J NEUROSCI, V28, P2252, DOI 10.1523/JNEUROSCI.2742-07.2008
   Osherson D, 1998, NEUROPSYCHOLOGIA, V36, P369, DOI 10.1016/S0028-3932(97)00099-7
   Panouilleres M., 2011, HUM BRAIN MAPP, V33, P1512
   PascualLeone A, 1996, EXP BRAIN RES, V107, P479
   Passot J.-B., 2009, ADV COMPUT INTELL LE, P287
   PELLIONISZ A, 1982, NEUROSCIENCE, V7, P2949, DOI 10.1016/0306-4522(82)90224-X
   Peng J, 2010, EUR J RADIOL, V80, P395
   Pernet CR, 2009, BMC NEUROSCI, V10, DOI 10.1186/1471-2202-10-67
   Petacchi A, 2005, HUM BRAIN MAPP, V25, P118, DOI 10.1002/hbm.20137
   Petrides M, 2000, EXP BRAIN RES, V133, P44, DOI 10.1007/s002210000399
   Petrosini L, 1998, PROG NEUROBIOL, V56, P191, DOI 10.1016/S0301-0082(98)00036-7
   Petrosini L, 2007, NEUROSCIENTIST, V13, P335, DOI 10.1177/1073858407300687
   Pierce K, 2001, BIOL PSYCHIAT, V49, P655, DOI 10.1016/S0006-3223(00)01008-8
   Pijpers A, 2006, J NEUROSCI, V26, P12067, DOI 10.1523/JNEUROSCI.2905-06.2006
   Ploghaus A, 2003, TRENDS COGN SCI, V7, P197, DOI 10.1016/S1364-6613(03)00061-5
   Pochon JB, 2001, CEREB CORTEX, V11, P260, DOI 10.1093/cercor/11.3.260
   Prevosto V, 2010, CEREB CORTEX, V20, P214, DOI 10.1093/cercor/bhp091
   Rae C, 2002, NEUROPSYCHOLOGIA, V40, P1285, DOI 10.1016/S0028-3932(01)00216-0
   Ramnani N, 2004, NAT REV NEUROSCI, V5, P184, DOI 10.1038/nrn1343
   Ramnani N, 2006, CEREB CORTEX, V16, P811, DOI 10.1093/cercor/bhj024
   Ramus F, 2003, CURR OPIN NEUROBIOL, V13, P212, DOI 10.1016/S0959-4388(03)00035-7
   Ravizza SM, 2006, BRAIN, V129, P306, DOI 10.1093/brain/awh685
   Riby DM, 2008, NEUROPSYCHOLOGIA, V46, P2855, DOI 10.1016/j.neuropsychologia.2008.05.003
   Richter S, 2004, NEUROPSYCHOLOGIA, V42, P1235, DOI 10.1016/j.neuropsychologia.2004.01.006
   Ridderinkhof KR, 2004, SCIENCE, V306, P443, DOI 10.1126/science.1100301
   Ridler K, 2006, P NATL ACAD SCI USA, V103, P15651, DOI 10.1073/pnas.0602639103
   Rissman J, 2003, J COGNITIVE NEUROSCI, V15, P1160, DOI 10.1162/089892903322598120
   ROBINSON FR, 1993, J NEUROPHYSIOL, V70, P1741
   ROUILLER EM, 1994, J COMP NEUROL, V345, P185, DOI 10.1002/cne.903450204
   Ruigrok TJ, 2010, CEREBELLUM, V10, P464
   Rushworth MFS, 2006, CEREB CORTEX, V16, P1418, DOI 10.1093/cercor/bhj079
   RYDING E, 1993, COGNITIVE BRAIN RES, V1, P94, DOI 10.1016/0926-6410(93)90015-W
   Sacchetti B, 2005, NEUROSCIENTIST, V11, P217, DOI 10.1177/1073858405276428
   Salmi J, 2010, J COGNITIVE NEUROSCI, V22, P2663, DOI 10.1162/jocn.2009.21382
   Savitz J, 2009, NEUROSCI BIOBEHAV R, V33, P699, DOI 10.1016/j.neubiorev.2009.01.004
   Schaeken W, 1996, COGNITION, V60, P205, DOI 10.1016/0010-0277(96)00708-1
   Schmahmann J., 2006, BRAIN, V129, P288
   Schmahmann JD, 1998, BRAIN, V121, P561, DOI 10.1093/brain/121.4.561
   Schmahmann JD, 2004, J NEUROPSYCH CLIN N, V16, P367, DOI 10.1176/appi.neuropsych.16.3.367
   Schmitt JE, 2001, J PSYCHIAT RES, V35, P225, DOI 10.1016/S0022-3956(01)00024-3
   Schutter DJLG, 2005, J PSYCHIATR NEUROSCI, V30, P91
   Schweizer T. A., 2007, NEUROREHAB NEURAL RE, V22, P72, DOI 10.1177/1545968307305303
   Seger CA, 2000, NEUROPSYCHOLOGY, V14, P361, DOI 10.1037//0894-4105.14.3.361
   Shadmehr R, 2012, COMPUT NEUROSCI-MIT, P1
   Shenton ME, 2001, SCHIZOPHR RES, V49, P1, DOI 10.1016/S0920-9964(01)00163-3
   Shin JC, 2003, J COGNITIVE NEUROSCI, V15, P1232, DOI 10.1162/089892903322598175
   Silveri MC, 2001, J NEUROL NEUROSUR PS, V71, P114, DOI 10.1136/jnnp.71.1.114
   Smet H. J. D., 2007, FOLIA PHONIATR LOGO, V59, P165
   SNIDER RS, 1976, J NEUROSCI RES, V2, P133, DOI 10.1002/jnr.490020204
   Spitzer M., 1998, MIND NET MODEL LEARN
   Stein J, 2001, Dyslexia, V7, P12, DOI 10.1002/dys.186
   Stephan KE, 2009, SCHIZOPHRENIA BULL, V35, P509, DOI 10.1093/schbul/sbn176
   Strakowski SM, 2005, AM J PSYCHIAT, V162, P1697, DOI 10.1176/appi.ajp.162.9.1697
   Straube A., 2007, NEUROOPHTHALMOLOGY N
   Strick PL, 2009, ANNU REV NEUROSCI, V32, P413, DOI 10.1146/annurev.neuro.31.060407.125606
   Synofzik M, 2008, CURR BIOL, V18, P814, DOI 10.1016/j.cub.2008.04.071
   Synofzik M, 2010, BRAIN, V133, P262, DOI 10.1093/brain/awp291
   Szpunar KK, 2010, MEM COGNITION, V38, P531, DOI 10.3758/MC.38.5.531
   Szpunar KK, 2011, CORTEX, V47, P409, DOI 10.1016/j.cortex.2010.07.008
   Szwed M, 2003, NEURON, V40, P621, DOI 10.1016/S0896-6273(03)00671-8
   Takagi M, 2000, J NEUROPHYSIOL, V83, P2047
   TALLAL P, 1993, ANN NY ACAD SCI, V682, P27, DOI 10.1111/j.1749-6632.1993.tb22957.x
   Tavano A, 2010, CORTEX, V46, P907, DOI 10.1016/j.cortex.2009.07.017
   Tilikete C, 2006, EXP BRAIN RES, V174, P555, DOI 10.1007/s00221-006-0495-6
   Tononi G, 1998, SCIENCE, V282, P1846, DOI 10.1126/science.282.5395.1846
   Townsend J, 1999, J NEUROSCI, V19, P5632
   Tunik E, 2005, NAT NEUROSCI, V8, P505, DOI 10.1038/nn1430
   Turner BM, 2007, NEUROPSYCHOLOGIA, V45, P1331, DOI 10.1016/j.neuropsychologia.2006.09.023
   Uusisaari MY, 2012, CEREBELLUM, V11, P420, DOI 10.1007/s12311-011-0350-6
   Vandervert LR, 2003, NEW IDEAS PSYCHOL, V21, P15, DOI 10.1016/S0732-118X(01)00014-9
   Vandervert LR, 2007, HIGH ABIL STUD, V18, P89, DOI 10.1080/13598130701350940
   Vandervert LR, 2007, CREATIVITY RES J, V19, P1
   Voogd J., 2010, CEREBELLUM, V10, P334
   Wang S, 2008, NEUROBIOL DIS, V29, P52, DOI 10.1016/j.nbd.2007.07.027
   Watson Thomas C, 2009, Front Integr Neurosci, V3, P18, DOI 10.3389/neuro.07.018.2009
   WEINBERGER DR, 1986, ARCH GEN PSYCHIAT, V43, P114
   WEINBERGER DR, 1988, ARCH GEN PSYCHIAT, V45, P609
   Wiech K, 2008, TRENDS COGN SCI, V12, P306, DOI 10.1016/j.tics.2008.05.005
   Wolpert DM, 1998, TRENDS COGN SCI, V2, P338, DOI 10.1016/S1364-6613(98)01221-2
   Xiang HD, 2003, HUM BRAIN MAPP, V18, P208, DOI 10.1002/hbm.10095
   Yakusheva TA, 2007, NEURON, V54, P973, DOI 10.1016/j.neuron.2007.06.003
   Zhu JN, 2006, BRAIN RES REV, V52, P93, DOI 10.1016/j.brainresrev.2006.01.003
NR 265
TC 39
Z9 39
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5110
J9 FRONT NEURAL CIRCUIT
JI Front. Neural Circuits
PD JAN 10
PY 2013
VL 6
AR 116
DI 10.3389/fncir.2012.00116
PG 23
WC Neurosciences
SC Neurosciences & Neurology
GA 067UL
UT WOS:000313320500001
PM 23335884
ER

PT J
AU Gadow, KD
   DeVincent, CJ
   Siegal, VI
   Olvet, DM
   Kibria, S
   Kirsch, SF
   Hatchwell, E
AF Gadow, Kenneth D.
   DeVincent, Carla J.
   Siegal, Victoria I.
   Olvet, Doreen M.
   Kibria, Saniya
   Kirsch, Sarah F.
   Hatchwell, Eli
TI Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism
   spectrum disorder
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE 5-HTTLPR; Attention-deficit hyperactivity disorder; Autism spectrum
   disorder; Serotonin; SLC6A4 gene
ID SEROTONIN TRANSPORTER GENE; PERVASIVE DEVELOPMENTAL DISORDER;
   OPPOSITIONAL DEFIANT DISORDER; CHILD SYMPTOM INVENTORY-4; DSM-IV;
   SCORING ALGORITHMS; POLYMORPHIC REGION; CLINICAL PHENOTYPE;
   SCHIZOPHRENIA; EXPRESSION
AB Background: The aims of the present study were to examine the association between a common serotonin transporter gene (SLC6A4) polymorphism 5-HTTLPR/rs25531 with severity of attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) symptoms.
   Methods: Mothers and teachers completed a validated DSM-IV-referenced rating scale for ADHD and ASD symptoms in 118 children with ASD.
   Results: Analyses indicated that children with at least one copy of the S or L-G allele obtained significantly more severe maternal ratings of hyperactivity (p = 0.001; eta p(2) = 0.097) and impulsivity (p = 0.027; eta p(2) = 0.044) but not inattention (p= 0.061; eta p(2) = 0.032), controlling for ASD severity, than children homozygous for the L-A allele. Conversely, mothers' ratings indicated that children with L-A/L-A genotype had more severe ASD social deficits than S or L-G allele carriers (p = 0.003; eta p(2) = 0.081), controlling for ADHD symptom severity. Teachers' ratings though consistent with mothers' ratings of hyperactivity and social deficits were marginally significant (p = 0.07/p = 0.09). There was some evidence that the magnitude of parent-teacher agreement regarding symptom severity varied as a function of the child's genotype.
   Conclusion: The 5-HTTLPR/rs25531 polymorphism or its correlates may modulate severity of ADHD and ASD symptoms in children with ASD, but in different ways. These tentative, hypothesis-generating findings require replication with larger independent samples. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Gadow, Kenneth D.] SUNY Stony Brook, Dept Psychiat & Behav Sci, Stony Brook, NY 11794 USA.
   [DeVincent, Carla J.] SUNY Stony Brook, Dept Radiol, Stony Brook, NY 11794 USA.
   [Siegal, Victoria I.; Hatchwell, Eli] SUNY Stony Brook, Dept Pathol, Stony Brook, NY 11794 USA.
   [Olvet, Doreen M.] Columbia Univ, New York State Psychiat Inst, MIND, New York, NY 10032 USA.
   [Kibria, Saniya; Kirsch, Sarah F.] SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA.
RP Gadow, KD (reprint author), SUNY Stony Brook, Dept Psychiat & Behav Sci, Stony Brook, NY 11794 USA.
EM kenneth.gadow@stonybrook.edu; carla.devincent@stonybrook.edu;
   victoria.skaya@gmail.com; do2271@columbia.edu; skibria1@gmail.com;
   sarah.kirsch1@gmail.com; elihatchwell@gmail.com
FU National Institutes of Health (GCRC) [M01RR10710]; National Alliance for
   Autism Research; Matt and Debra Cody Center for Autism and Developmental
   Disorders
FX This study was supported, in part, by grants from the National
   Institutes of Health (GCRC grant no. M01RR10710), the National Alliance
   for Autism Research, the Matt and Debra Cody Center for Autism and
   Developmental Disorders, and charitable contributions. The authors wish
   to thank Dr. John Pomeroy for supervision of the clinical diagnoses,
   Drs. Patricia Whitaker-Azmitia, Efrain Azmitia, and Greg Perlman for
   their comments on the manuscript, and two anonymous reviewers for their
   suggestions.
CR ABRAMSON RK, 1989, J AUTISM DEV DISORD, V19, P397, DOI 10.1007/BF02212938
   Altamura C, 2007, CEREB CORTEX, V17, P1394, DOI 10.1093/cercor/bhl051
   Azmitia EC, 2011, NEUROPHARMACOLOGY, V60, P1347, DOI 10.1016/j.neuropharm.2011.02.002
   Belsky J, 2009, MOL PSYCHIATR, V14, P746, DOI 10.1038/mp.2009.44
   Bonnin A, 2011, NATURE, V472, P347, DOI 10.1038/nature09972
   Brummett BH, 2008, BEHAV GENET, V38, P34, DOI 10.1007/s10519-007-9172-1
   Brune CW, 2006, AM J PSYCHIAT, V163, P2148, DOI 10.1176/appi.ajp.163.12.2148
   Ciarleglio CM, 2011, NEUROSCIENCE, V197, P8, DOI 10.1016/j.neuroscience.2011.09.036
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Cook EH, 1997, MOL PSYCHIATR, V2, P247
   Crespi B, 2010, P NATL ACAD SCI USA, V107, P1736, DOI 10.1073/pnas.0906080106
   Crespi BJ, 2011, GENES BRAIN BEHAV, V10, P689, DOI 10.1111/j.1601-183X.2011.00710.x
   DeVincent CJ, 2009, AUTISM RES, V2, P312, DOI 10.1002/aur.106
   Devlin B, 2005, MOL PSYCHIATR, V10, P1110, DOI 10.1038/sj.mp.4001724
   Ebstein RP, 2006, MOL PSYCHIATR, V11, P427, DOI 10.1038/sj.mp.4001814
   Fan X, 2011, BEHAV NEUROSCIENCE A
   Fox E, 2011, BIOL PSYCHIAT, V70, P1049, DOI 10.1016/j.biopsych.2011.07.004
   Gadow K. D., 2002, CHILD SYMPTOM INVENT
   Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x
   Gadow KD, 2012, RES DEV DISABIL, V33, P1157, DOI 10.1016/j.ridd.2012.01.004
   Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079
   Gadow KD, 2012, J AUTISM DEV DISORD, V42, P1353, DOI 10.1007/s10803-011-1367-x
   Gadow KD, 2002, DEV MED CHILD NEUROL, V44, P330
   Gadow KD, 2011, SYMPTOM INVENTORIES
   Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1302, DOI 10.1007/s10803-007-0516-8
   Gadow KD, 1986, STONY BROOK CHILD PS
   Gadow KD, 2006, J AUTISM DEV DISORD, V36, P271, DOI 10.1007/s10803-005-0060-3
   Gadow KD, 2012, J AUTISM DEV DISORD, V42, P2285, DOI 10.1007/s10803-012-1473-4
   Gadow KD, 2008, J AUTISM DEV DISORD, V38, P419, DOI 10.1007/s10803-007-0408-y
   Gizer IR, 2009, HUM GENET, V126, P51, DOI 10.1007/s00439-009-0694-x
   Guerini FR, 2011, PHARMACOL RES, V64, P283, DOI 10.1016/j.phrs.2011.03.015
   Guttmann-Steinmetz S, 2010, J AUTISM DEV DISORD, V40, P1006, DOI 10.1007/s10803-010-0950-x
   Hariri AR, 2005, ARCH GEN PSYCHIAT, V62, P146, DOI 10.1001/archpsyc.62.2.146
   Heils A, 1996, J NEUROCHEM, V66, P2621
   Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA
   Hu VW, 2009, AUTISM RES, V2, P78, DOI 10.1002/aur.73
   Hu XZ, 2006, AM J HUM GENET, V78, P815, DOI 10.1086/503850
   Huang CH, 2008, AM J MED GENET B, V147B, P903, DOI 10.1002/ajmg.b.30720
   Kistner-Griffin E, 2011, AM J MED GENET B, V156B, P139, DOI 10.1002/ajmg.b.31146
   Klauck SM, 1997, HUM MOL GENET, V6, P2232
   Komers PE, 1997, CAN J ZOOL, V75, P161, DOI 10.1139/z97-023
   Kronenberg S, 2008, PHARMACOGENOMICS, V9, P1725, DOI 10.2217/14622416.9.11.1725
   Kuepper Y, 2012, GENES BRAIN BEHAV, V11, P643, DOI 10.1111/j.1601-183X.2012.00783.x
   Lam KSL, 2006, RES DEV DISABIL, V27, P254, DOI 10.1016/j.ridd.2005.03.003
   Landaas ET, 2010, GENES BRAIN BEHAV, V9, P449, DOI 10.1111/j.1601-183X.2010.00567.x
   Lecavalier L, 2009, J CHILD PSYCHOL PSYC, V50, P1246, DOI 10.1111/j.1469-7610.2009.02104.x
   Lecavalier L, 2009, J AUTISM DEV DISORD, V39, P278, DOI 10.1007/s10803-008-0622-2
   Lee LC, 2008, PAEDIATR PERINAT EP, V22, P172, DOI 10.1111/j.1365-3016.2007.00919.x
   LESCH KP, 1994, J NEURAL TRANSM-GEN, V95, P157, DOI 10.1007/BF01276434
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MacKenzie A, 1999, P NATL ACAD SCI USA, V96, P15251, DOI 10.1073/pnas.96.26.15251
   McNamara IM, 2008, BRAIN RES, V1189, P203, DOI 10.1016/j.brainres.2007.10.063
   Mulder EJ, 2005, AM J MED GENET B, V133B, P93, DOI 10.1002/ajmg.b.30122
   Murphy DGM, 2006, AM J PSYCHIAT, V163, P934, DOI 10.1176/appi.ajp.163.5.934
   Murphy DL, 2008, NEUROPHARMACOLOGY, V55, P932, DOI 10.1016/j.neuropharm.2008.08.034
   Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
   Piersma T, 2003, TRENDS ECOL EVOL, V18, P228, DOI 10.1016/S0169-5347(03)00036-3
   Praschak-Rieder N, 2007, BIOL PSYCHIAT, V62, P327, DOI 10.1016/j.biopsych.2006.09.022
   Ramocki MB, 2008, NATURE, V455, P912, DOI 10.1038/nature07457
   Rommelse NNJ, 2011, NEUROSCI BIOBEHAV R, V35, P1363, DOI 10.1016/j.neubiorev.2011.02.015
   Roohi J, 2009, J AUTISM DEV DISORD, V39, P67, DOI 10.1007/s10803-008-0600-8
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8
   Serretti A, 2006, CURR DRUG TARGETS, V7, P1659, DOI 10.2174/138945006779025419
   Shapiro A.K., 1988, GILLES TOURETTE SYND
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Sizoo B, 2010, WORLD J BIOL PSYCHIA, V11, P699, DOI 10.3109/15622975.2010.480985
   Sporn AL, 2004, BIOL PSYCHIAT, V55, P989, DOI 10.1016/j.biopsych.2004.01.019
   Tordjman S, 2001, MOL PSYCHIATR, V6, P434, DOI 10.1038/sj.mp.4000873
   Tudor ME, 2012, RES AUTISM SPECT DIS, V6, P1401, DOI 10.1016/j.rasd.2012.06.001
   Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109
   Wassink TH, 2007, ARCH GEN PSYCHIAT, V64, P709, DOI 10.1001/archpsyc.64.6.709
   Wendland JR, 2006, MOL PSYCHIATR, V11, P224, DOI 10.1038/sj.mp.4001789
   Whitaker-Azmitia PM, 2001, BRAIN RES BULL, V56, P479, DOI 10.1016/S0361-9230(01)00615-3
   Willeit M, 2010, NEUROIMAGE, V53, P878, DOI 10.1016/j.neuroimage.2010.04.030
   Wilson S. W., 1998, PHILOS T ROY SOC LON, V353, P199
   Zhang HP, 2010, PHYSIOL GENOMICS, V42, P85, DOI 10.1152/physiolgenomics.00220.2009
NR 77
TC 10
Z9 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JAN 10
PY 2013
VL 40
BP 292
EP 297
DI 10.1016/j.pnpbp.2012.10.019
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 096RR
UT WOS:000315422500043
PM 23123360
ER

PT J
AU Busa, T
   Chabrol, B
   Perret, O
   Longy, M
   Philip, N
AF Busa, Tiffany
   Chabrol, Brigitte
   Perret, Odile
   Longy, Michel
   Philip, Nicole
TI Novel PTEN germline mutation in a family with mild phenotype:
   Difficulties in genetic counseling
SO GENE
LA English
DT Article
DE PTEN; Familial macrocephaly; Genetic counseling
ID RILEY-RUVALCABA-SYNDROME; AUTISM SPECTRUM DISORDERS; COWDEN-SYNDROME;
   DEVELOPMENTAL DELAY; DISEASE; INDIVIDUALS
AB PTEN gene (phosphatase and tensin homolog deleted on chromosome ten, MIM 601628) is a tumor suppressor gene implicated in PTEN hamartoma tumor syndromes (PHTS) including Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome and Proteus-like syndrome. PTEN mutations have been more recently reported in children with macrocephaly and autism spectrum disorders or mental retardation, without other symptoms of PHTS. Although tumor risk has not been evaluated in these patients and their relatives, the same surveillance as for Cowden syndrome is usually proposed. We report a family including patients carrying a novel PTEN mutation and presenting with a mild phenotype consisting of macrocephaly, hypotonia during the first year of life and mild learning disabilities, without autistic features. None of these patients exhibited PTHS-related symptoms such as tumors, lipomas, vascular malformations or pigmented macules of the glans penis. This report raises the question of extending the indications of PTEN mutation screening to familial macrocephaly with learning disabilities. Detection of a mutation in this family led to difficult questions about surveillance, genetic counseling and familial information since the mother declined tumor screening and disclosure of genetic risk information to at-risk relatives. (c) 2012 Elsevier B.V. All rights reserved.
C1 [Busa, Tiffany; Perret, Odile; Philip, Nicole] CHU Timone Enfants, APHM, Unite Genet Clin, Marseille, France.
   [Chabrol, Brigitte] CHU Timone Enfants, APHM, Serv Neurol Pediat, Marseille, France.
   [Longy, Michel] Inst Bergonie, Lab Genet Mol, Bordeaux, France.
RP Busa, T (reprint author), Hop Enfants La Timone, APHM, Unite Genet Clin, Dept Genet Med, 264 Rue St Pierre, F-13385 Marseille 05, France.
EM tiffany.busa@ap-hm.fr; brigitte.chabrol@ap-hm.fr; odile.perret@ap-hm.fr;
   longy@bergonie.org; nicole.philip@ap-hm.fr
CR Boccone L, 2006, AM J MED GENET A, V140A, P1965, DOI 10.1002/ajmg.a.31396
   Bonneau D, 2000, HUM MUTAT, V16, P109, DOI 10.1002/1098-1004(200008)16:2<109::AID-HUMU3>3.0.CO;2-0
   Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646
   Buxbaum JD, 2007, AM J MED GENET B, V144B, P484, DOI 10.1002/ajmg.b.30493
   Dasouki MJ, 2001, AM J HUM GENET, V69, P280
   Delatycki MB, 2003, J MED GENET, V40, DOI 10.1136/jmg.40.8.e92
   Eng C, 2003, HUM MUTAT, V22, P183, DOI 10.1002/humu.10257
   GORLIN RJ, 1992, AM J MED GENET, V44, P307, DOI 10.1002/ajmg.1320440309
   Han SY, 2000, CANCER RES, V60, P3147
   Hendriks Y M C, 2003, Fam Cancer, V2, P79, DOI 10.1023/A:1025713815924
   Herman GE, 2007, AM J MED GENET A, V143A, P589, DOI 10.1002/ajmg.a.31619
   Lachlan KL, 2007, J MED GENET, V44, DOI 10.1136/jmg.2007.049981
   Li J, 1997, SCIENCE, V275, P1943, DOI 10.1126/science.275.5308.1943
   Marsh DJ, 1999, HUM MOL GENET, V8, P1461, DOI 10.1093/hmg/8.8.1461
   McBride KL, 2010, AUTISM RES, V3, P137, DOI 10.1002/aur.132
   Orrico A, 2009, CLIN GENET, V75, P195, DOI 10.1111/j.1399-0004.2008.01074.x
   Parisi MA, 2001, J MED GENET, V38, P52, DOI 10.1136/jmg.38.1.52
   Schwarz JM, 2010, NAT METHODS, V7, P575, DOI 10.1038/nmeth0810-575
   Varga EA, 2009, GENET MED, V11, P111, DOI 10.1097/GIM.0b013e31818fd762
   Williams CA, 2008, AM J MED GENET A, V146A, P2023, DOI 10.1002/ajmg.a.32434
   Wright EMMB, 2010, ARCH DIS CHILD, V95, P724, DOI 10.1136/adc.2009.160069
   Zori RT, 1998, AM J MED GENET, V80, P399, DOI 10.1002/(SICI)1096-8628(19981204)80:4<399::AID-AJMG18>3.0.CO;2-O
NR 22
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
J9 GENE
JI Gene
PD JAN 10
PY 2013
VL 512
IS 2
BP 194
EP 197
DI 10.1016/j.gene.2012.09.134
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA 073UP
UT WOS:000313768900004
PM 23124040
ER

PT J
AU Grimsley, JMS
   Gadziola, MA
   Wenstrup, JJ
AF Grimsley, Jasmine M. S.
   Gadziola, Marie A.
   Wenstrup, Jeffrey J.
TI Automated classification of mouse pup isolation syllables: from cluster
   analysis to an Excel-based "mouse pup syllable classification
   calculator"
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE cluster analysis; mouse pup calls; vocalization; isolation calls; mouse
   song; communication call
ID ULTRASONIC VOCALIZATIONS; MONGOLIAN GERBILS; MICE; BEHAVIOR; CALLS;
   AUTISM; MODEL; DISCRIMINATION; SOUNDS; RATS
AB Mouse pups vocalize at high rates when they are cold or isolated from the nest. The proportions of each syllable type produced carry information about disease state and are being used as behavioral markers for the internal state of animals. Manual classifications of these vocalizations identified 10 syllable types based on their spectro-temporal features. However, manual classification of mouse syllables is time consuming and vulnerable to experimenter bias. This study uses an automated cluster analysis to identify acoustically distinct syllable types produced by CBA/CaJ mouse pups, and then compares the results to prior manual classification methods. The cluster analysis identified two syllable types, based on their frequency bands, that have continuous frequency-time structure, and two syllable types featuring abrupt frequency transitions. Although cluster analysis computed fewer syllable types than manual classification, the clusters represented well the probability distributions of the acoustic features within syllables. These probability distributions indicate that some of the manually classified syllable types are not statistically distinct. The characteristics of the four classified clusters were used to generate a Microsoft Excel-based mouse syllable classifier that rapidly categorizes syllables, with over a 90% match, into the syllable types determined by cluster analysis.
C1 [Grimsley, Jasmine M. S.; Gadziola, Marie A.; Wenstrup, Jeffrey J.] NE Ohio Med Univ, Dept Anat & Neurobiol, Rootstown, OH 44272 USA.
   [Gadziola, Marie A.; Wenstrup, Jeffrey J.] Kent State Univ, Sch Biomed Sci, Kent, OH 44242 USA.
RP Grimsley, JMS (reprint author), NE Ohio Med Univ, Dept Anat & Neurobiol, 4209 State Route 44,POB 95, Rootstown, OH 44272 USA.
EM jgrimsley@neomed.edu
FU National Institute on Deafness and Other Communication Disorders [R01
   DC00937, DC00937-19S1]
FX We would like to thank Shobhana Sivaramakrishnan for the animals used in
   this study, and Emily Hazlett for her comments on the manuscript. This
   research was supported by grants from the National Institute on Deafness
   and Other Communication Disorders R01 DC00937 and DC00937-19S1.
CR BERRYMAN JC, 1976, Z TIERPSYCHOL, V41, P80
   Branchi I, 1998, DEV PSYCHOBIOL, V33, P249, DOI 10.1002/(SICI)1098-2302(199811)33:3<249::AID-DEV5>3.0.CO;2-R
   Brudzynski SM, 1999, DEV PSYCHOBIOL, V34, P195, DOI 10.1002/(SICI)1098-2302(199904)34:3<195::AID-DEV4>3.0.CO;2-S
   Chabout J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029401
   Chiu T., 2001, P 7 ACM SIGKDD INT C
   D'Amato FR, 2005, BEHAV GENET, V35, P103, DOI 10.1007/s10519-004-0860-9
   Elleithy K., 2010, ADV TECHNIQUES COMPU
   Grimsley JMS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017460
   Hahn ME, 2002, BEHAV GENET, V32, P267, DOI 10.1023/A:1019728813891
   Hahn ME, 1997, BEHAV GENET, V27, P133, DOI 10.1023/A:1025637408900
   Hammerschmidt K, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-40
   HOLMAN SD, 1991, DEV PSYCHOBIOL, V24, P103, DOI 10.1002/dev.420240204
   Holy TE, 2005, PLOS BIOL, V3, P2177, DOI 10.1371/journal.pbio.0030386
   Keller M, 2006, CHEM SENSES, V31, P315, DOI 10.1093/chemse/bjj035
   LIBERMAN AM, 1957, J EXP PSYCHOL, V54, P358, DOI 10.1037/h0044417
   Liu RC, 2003, J ACOUST SOC AM, V114, P3412, DOI 10.1121/1.1623787
   McAllister BB, 2012, NEUROSCIENCE, V226, P356, DOI 10.1016/j.neuroscience.2012.09.024
   Mercado E, 2005, J COMP PSYCHOL, V119, P90, DOI 10.1037/0735-7036.119.1.90
   Mooi E, 2011, CONCISE GUIDE TO MARKET RESEARCH: THE PROCESS, DATA, AND METHODS USING IBM SPSS STATISTICS, P1, DOI 10.1007/978-3-642-12541-6
   Nagy CM, 2012, BIOACOUSTICS, V21, P127, DOI 10.1080/09524622.2011.651829
   Panksepp JB, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000351
   Portfors CV, 2007, J AM ASSOC LAB ANIM, V46, P28
   Pozzi L, 2010, AM J PRIMATOL, V72, P337, DOI 10.1002/ajp.20786
   Ren Y., 2009, ALGORITHMS, V2, P1410
   Ricceri L, 2007, BEHAV BRAIN RES, V176, P40, DOI 10.1016/j.bbr.2006.08.024
   Rupniak NMJ, 2000, NEUROPHARMACOLOGY, V39, P1413, DOI 10.1016/S0028-3908(00)00052-6
   SALES GD, 1978, DEV PSYCHOBIOL, V11, P595, DOI 10.1002/dev.420110609
   Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067
   SPSS, 2001, SPSS WHIT PAP
   Sugimoto H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022093
   Takahashi N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014115
   Tan P.-N., 2006, INTRO DATA MINING, DOI Pearson Addison Wesley
   Theodoridis S., 1999, PATTERN RECOGNITION
   Wesson DW, 2008, CHEM SENSES, V33, P581, DOI 10.1093/chemse/bjn029
   Wetzel W, 1998, BEHAV BRAIN RES, V91, P29, DOI 10.1016/S0166-4328(97)00099-5
   Wohr M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020631
   Wohr M, 2008, BEHAV GENET, V38, P579, DOI 10.1007/s10519-008-9221-4
   Wohr M, 2011, GENES BRAIN BEHAV, V10, P35, DOI 10.1111/j.1601-183X.2010.00582.x
   Young DM, 2010, P NATL ACAD SCI USA, V107, P11074, DOI 10.1073/pnas.1005620107
   Zorrilla EP, 1997, DEV PSYCHOBIOL, V30, P141, DOI 10.1002/(SICI)1098-2302(199703)30:2<141::AID-DEV5>3.0.CO;2-Q
NR 40
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD JAN 9
PY 2013
VL 6
AR 89
DI 10.3389/fnbeh.2012.00089
PG 12
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 084FB
UT WOS:000314522000001
ER

PT J
AU Freeth, M
   Foulsham, T
   Kingstone, A
AF Freeth, Megan
   Foulsham, Tom
   Kingstone, Alan
TI What Affects Social Attention? Social Presence, Eye Contact and Autistic
   Traits
SO PLOS ONE
LA English
DT Article
ID SPECTRUM DISORDERS; FUNCTIONING AUTISM; VISUAL INFORMATION; GAZE
   ALLOCATION; PATTERNS; CONVERSATION; ENVIRONMENT; PERCEPTION; MOVEMENTS;
   COGNITION
AB Social understanding is facilitated by effectively attending to other people and the subtle social cues they generate. In order to more fully appreciate the nature of social attention and what drives people to attend to social aspects of the world, one must investigate the factors that influence social attention. This is especially important when attempting to create models of disordered social attention, e.g. a model of social attention in autism. Here we analysed participants' viewing behaviour during one-to-one social interactions with an experimenter. Interactions were conducted either live or via video (social presence manipulation). The participant was asked and then required to answer questions. Experimenter eye-contact was either direct or averted. Additionally, the influence of participant self-reported autistic traits was also investigated. We found that regardless of whether the interaction was conducted live or via a video, participants frequently looked at the experimenter's face, and they did this more often when being asked a question than when answering. Critical differences in social attention between the live and video interactions were also observed. Modifications of experimenter eye contact influenced participants' eye movements in the live interaction only; and increased autistic traits were associated with less looking at the experimenter for video interactions only. We conclude that analysing patterns of eye-movements in response to strictly controlled video stimuli and natural real-world stimuli furthers the field's understanding of the factors that influence social attention.
C1 [Freeth, Megan] Univ Sheffield, Dept Psychol, Sheffield S10 2TN, S Yorkshire, England.
   [Foulsham, Tom] Univ Essex, Dept Psychol, Colchester CO4 3SQ, Essex, England.
   [Kingstone, Alan] Univ British Columbia, Dept Psychol, Vancouver, BC V5Z 1M9, Canada.
RP Freeth, M (reprint author), Univ Sheffield, Dept Psychol, Sheffield S10 2TN, S Yorkshire, England.
EM m.freeth@sheffield.ac.uk
FU Economic and Social Research Council [PTA-026-27-2283]; Wellcome Trust
   VIP award; Leverhulme Early Career Fellowship [ECF/2010/0592];
   Commonwealth Fellowship from the Government of Canada; Natural Sciences
   and Engineering Research Council of Canada (NSERC) operating grant
FX MF was supported by Economic and Social Research Council
   (PTA-026-27-2283), a Wellcome Trust VIP award and a Leverhulme Early
   Career Fellowship (ECF/2010/0592). TF was supported by a Commonwealth
   Fellowship from the Government of Canada. AK was supported by a Natural
   Sciences and Engineering Research Council of Canada (NSERC) operating
   grant. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
CR Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Bird G, 2011, J AUTISM DEV DISORD, V41, P1556, DOI 10.1007/s10803-011-1183-3
   Birmingham E, 2008, Q J EXP PSYCHOL, V61, P986, DOI 10.1080/17470210701410375
   Brown-Schmidt S, 2008, COGNITIVE SCI, V32, P643, DOI 10.1080/03640210802066816
   Chen FS, 2011, J AUTISM DEV DISORD, V41, P1131, DOI 10.1007/s10803-010-1136-2
   Csibra G, 2006, ATTENTION PERFORM, P249
   Doherty-Sneddon G, 2005, MEM COGNITION, V33, P727, DOI 10.3758/BF03195338
   Doherty-Sneddon G, 2002, DEV PSYCHOL, V38, P438, DOI 10.1037//0012-1649.38.3.438
   Droll JA, 2009, VIS COGN, V17, P1159, DOI 10.1080/13506280902797125
   ELLSWORT.PC, 1972, J PERS SOC PSYCHOL, V21, P302, DOI 10.1037/h0032323
   Farroni T, 2002, P NATL ACAD SCI USA, V99, P9602, DOI 10.1073/pnas.152159999
   Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016
   Foulsham T, 2011, VISION RES, V51, P1920, DOI 10.1016/j.visres.2011.07.002
   Foulsham T, 2010, COGNITION, V117, P319, DOI 10.1016/j.cognition.2010.09.003
   Freeth M, 2010, J AUTISM DEV DISORD, V40, P534, DOI 10.1007/s10803-009-0893-2
   Freeth M, 2010, J EXP CHILD PSYCHOL, V105, P20, DOI 10.1016/j.jecp.2009.10.001
   Frischen A, 2007, PSYCHOL BULL, V133, P694, DOI 10.1037/0033-2909.133.4.694
   Gallup AC, 2012, BIOL LETTERS, V8, P520, DOI 10.1098/rsbl.2012.0160
   Glenberg AM, 1998, MEM COGNITION, V26, P651, DOI 10.3758/BF03211385
   GUERIN B, 1986, J EXP SOC PSYCHOL, V22, P38, DOI 10.1016/0022-1031(86)90040-5
   Hayhoe M, 2005, TRENDS COGN SCI, V9, P188, DOI 10.1016/j.tics.2005.02.009
   Kingstone A, 2008, BRIT J PSYCHOL, V99, P317, DOI 10.1348/000712607X251243
   KLEINKE CL, 1986, PSYCHOL BULL, V100, P78, DOI 10.1037//0033-2909.100.1.78
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Laidlaw K, J VISION IN PRESS, V11, P620
   Laidlaw KEW, 2011, P NATL ACAD SCI USA, V108, P5548, DOI 10.1073/pnas.1017022108
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Nadig A, 2010, NEUROPSYCHOLOGIA, V48, P2730, DOI 10.1016/j.neuropsychologia.2010.05.020
   Nakano T, 2010, P ROY SOC B-BIOL SCI, V277, P2935, DOI 10.1098/rspb.2010.0587
   Norbury CF, 2009, J CHILD PSYCHOL PSYC, V50, P834, DOI 10.1111/j.1469-7610.2009.02073.x
   Noris B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044144
   OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
   Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
   Ponkanen LM, 2011, SOC COGN AFFECT NEUR, V6, P486, DOI 10.1093/scan/nsq068
   Riby DM, 2008, NEUROPSYCHOLOGIA, V46, P2855, DOI 10.1016/j.neuropsychologia.2008.05.003
   Richardson DC, 2007, PSYCHOL SCI, V18, P407, DOI 10.1111/j.1467-9280.2007.01914.x
   Risko EF, CAMBRIDGE H IN PRESS
   Risko EF, 2011, ATTEN PERCEPT PSYCHO, V73, P291, DOI 10.3758/s13414-010-0042-1
   Risko Evan F, 2012, Front Hum Neurosci, V6, P143, DOI 10.3389/fnhum.2012.00143
   Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7
   Schilbach L., BEHAV BRAIN IN PRESS
   Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009
   Spezio ML, 2007, J NEUROSCI, V27, P3994, DOI 10.1523/JNEUROSCI.3789-06.2007
   Stein T, 2011, COGNITION, V119, P307, DOI 10.1016/j.cognition.2011.01.008
   Vatikiotis-Bateson E, 1998, PERCEPT PSYCHOPHYS, V60, P926, DOI 10.3758/BF03211929
   von Hofsten C, 2009, RES AUTISM SPECT DIS, V3, P556, DOI 10.1016/j.rasd.2008.12.003
NR 47
TC 9
Z9 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 9
PY 2013
VL 8
IS 1
AR e53286
DI 10.1371/journal.pone.0053286
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 070YR
UT WOS:000313551500058
PM 23326407
ER

PT J
AU Deane, EC
   Ilie, AE
   Sizdahkhani, S
   Das Gupta, M
   Orlowski, J
   McKinney, RA
AF Deane, Emily C.
   Ilie, Alina E.
   Sizdahkhani, Saman
   Das Gupta, Micaela
   Orlowski, John
   McKinney, R. Anne
TI Enhanced Recruitment of Endosomal Na+/H+ Exchanger NHE6 into Dendritic
   Spines of Hippocampal Pyramidal Neurons during NMDA Receptor-Dependent
   Long-Term Potentiation
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID LINKED MENTAL-RETARDATION; AMPA RECEPTORS; RECYCLING ENDOSOMES; SYNAPTIC
   PLASTICITY; GLUTAMATE TRANSPORT; ANGELMAN-SYNDROME; PLASMA-MEMBRANE;
   ENDOCYTIC ZONES; SLICE CULTURES; SMALL GTPASE
AB Postsynaptic endosomal trafficking has emerged as a principal regulatory mechanism of structural and functional plasticity of glutamatergic synapses. Recycling endosomes perform activity-dependent transport of AMPA receptors(AMPARs) and lipids to the postsynaptic membrane, activities that are known to contribute to long-term synaptic potentiation and hypothesized to subserve learning and memory processes in the brain. Recently, genetic defects in a widely expressed vesicular pH-regulating transporter, the Na+/H+ exchanger NHE6 isoform, have been implicated in neurodevelopmental disorders including severe X-linked mental retardation and autism. However, little information is available regarding the cellular properties of this transporter in the CNS. Here, we show by quantitative light microscopy that the protein abundance of NHE6 is developmentally regulated in area CA1 of the mouse hippocampus. Within pyramidal neurons, NHE6 was found to localize to discrete puncta throughout the soma and neurites, with noticeable accumulation at dendritic spines and presynaptic terminals. Dual immunolabeling of dendritic spines revealed that NHE6 partially colocalizes with typical markers of early and recycling endosomes as well as with the AMPAR subunit GluA1. Significantly, NHE6-containing vesicles exhibited enhanced translocation to dendritic spine heads during NMDA receptor (NMDAR)-dependent long-term potentiation. These data suggest that NHE6 may play a unique, previously unrecognized, role at glutamatergic synapses that are important for learning and memory.
C1 [Deane, Emily C.; Sizdahkhani, Saman; Das Gupta, Micaela; McKinney, R. Anne] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3G 0B1, Canada.
   [Ilie, Alina E.; Orlowski, John] McGill Univ, Dept Physiol, Montreal, PQ H3G 0B1, Canada.
   [McKinney, R. Anne] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 0B1, Canada.
RP McKinney, RA (reprint author), McGill Univ, Dept Pharmacol & Therapeut, Bellini Life Sci Complex,Room 167,3649 Promenade, Montreal, PQ H3G 0B1, Canada.
EM john.orlowski@mcgill.ca; anne.mckinney@mcgill.ca
FU Canadian Institutes of Health Research [MOP-86724, MOP-11221,
   MOP-111191]; ARSACS Foundation; Natural Sciences and Engineering
   Research Council of Canada; McGill Provost's Graduate Fellowship; Le
   Fonds de la Recherche en Sante de Quebec
FX This work was supported by Canadian Institutes of Health Research
   funding held by R. A. M. (MOP-86724) and J. O. (MOP-11221 and
   MOP-111191). E. C. D. held a McGill Provost's Graduate Fellowship and
   received funding from the ARSACS Foundation. M. D. G. received a Natural
   Sciences and Engineering Research Council of Canada Studentship. R. A.
   M. held a Le Fonds de la Recherche en Sante de Quebec Senior Salary
   Bursary during the period of this work. We thank Francois Charron,
   Philip K.-Y. Chang, David Verbich, Haider Altimini, and Tushare Jinadasa
   for their technical assistance. We also thank Dr. David Stellwagen for
   generously providing us with DNA constructs and Dr. Keith Murai for
   assistance with experimental design and for critical reading of this
   manuscript. We also acknowledge the technical assistance provided by the
   McGill Life Sciences Imaging Facility, the Electron Microscopy Facility
   of the Department of Pharmacology and Therapeutics (McGill University),
   and Genome Quebec.
CR Blanpied TA, 2002, NEURON, V36, P435, DOI 10.1016/S0896-6273(02)00979-0
   Bourne J, 2007, CURR OPIN NEUROBIOL, V17, P381, DOI 10.1016/j.conb.2007.04.009
   Brett CL, 2002, AM J PHYSIOL-CELL PH, V282, pC1031, DOI 10.1152/ajpcell.00420.2001
   Brown TC, 2005, NEURON, V45, P81, DOI 10.1016/j.neuron.2004.12.023
   Brown TC, 2007, J NEUROSCI, V27, P13311, DOI 10.1523/JNEUROSCI.4258-07.2007
   Burry RW, 2000, J HISTOCHEM CYTOCHEM, V48, P163
   CAMERON PL, 1991, J CELL BIOL, V115, P151, DOI 10.1083/jcb.115.1.151
   Chavez RA, 1996, J CELL BIOL, V133, P1177, DOI 10.1083/jcb.133.6.1177
   Cooney JR, 2002, J NEUROSCI, V22, P2215
   Coorssen JR, 1996, EMBO J, V15, P3787
   Dailey ME, 1996, J NEUROSCI, V16, P2983
   DAVIES J, 1986, BRAIN RES, V382, P169, DOI 10.1016/0006-8993(86)90127-7
   Dean C, 2012, MOL BIOL CELL, V23, P1715, DOI 10.1091/mbc.E11-08-0707
   De Paola V, 2003, NAT NEUROSCI, V6, P491, DOI 10.1038/nn1046
   Diering GH, 2011, MOL BIOL CELL, V22, P2246, DOI 10.1091/mbc.E11-01-0066
   Ehlers MD, 2000, NEURON, V28, P511, DOI 10.1016/S0896-6273(00)00129-X
   Engert F, 1999, NATURE, V399, P66
   Fiala JC, 1998, J NEUROSCI, V18, P8900
   Fiala JC, 2002, BRAIN RES REV, V39, P29, DOI 10.1016/S0165-0173(02)00158-3
   Fortin DA, 2010, J NEUROSCI, V30, P11565, DOI 10.1523/JNEUROSCI.1746-10.2010
   Gahwiler BH, 1997, TRENDS NEUROSCI, V20, P471, DOI 10.1016/S0166-2236(97)01122-3
   Gahwiler BH, 1998, CULTURING NERVE CELL
   Garbern JY, 2010, BRAIN, V133, P1391, DOI 10.1093/brain/awq071
   Gerges NZ, 2006, EMBO J, V25, P1623, DOI 10.1038/sj.emboj.7601065
   Gerges NZ, 2004, J BIOL CHEM, V279, P43870, DOI 10.1074/jbc.M404982200
   Gilfillan GD, 2008, AM J HUM GENET, V82, P1003, DOI 10.1016/j.ajhg.2008.01.013
   Goh GY, 2011, NAT NEUROSCI, V14, P1285, DOI 10.1038/nn.2898
   HARRIS KM, 1992, J NEUROSCI, V12, P2685
   Higgins D, 1998, CULTURING NERVE CELL
   Holtmaat AJGD, 2005, NEURON, V45, P279, DOI 10.1016/j.neuron.2005.01.003
   Jiang M, 2006, NAT PROTOC, V1, P695, DOI 10.1038/nprot.2006.86
   JOHNSON JW, 1987, NATURE, V325, P529, DOI 10.1038/325529a0
   Kasai H, 2010, TRENDS NEUROSCI, V33, P121, DOI 10.1016/j.tins.2010.01.001
   Kennedy MJ, 2006, ANNU REV NEUROSCI, V29, P325, DOI 10.1146/annurev.neuro.29.051605.112808
   Kennedy MJ, 2010, CELL, V141, P524, DOI 10.1016/j.cell.2010.02.042
   Kennedy MJ, 2011, NEURON, V69, P856, DOI 10.1016/j.neuron.2011.02.032
   Kopec CD, 2007, J NEUROSCI, V27, P13706, DOI 10.1523/JNEUROSCI.3503-07.2007
   Kopec CD, 2006, J NEUROSCI, V26, P2000, DOI 10.1523/JNEUROSCI.3918-05.2006
   Lau CG, 2010, J NEUROSCI, V30, P242, DOI 10.1523/JNEUROSCI.4933-08.2010
   Lein ES, NATURE, V445, P168
   Lin JW, 2000, NAT NEUROSCI, V3, P1282, DOI 10.1038/81814
   Lu J, 2007, NEURON, V55, P874, DOI 10.1016/j.neuron.2007.06.041
   Lu WY, 2001, NEURON, V29, P243, DOI 10.1016/S0896-6273(01)00194-5
   Lynch MA, 2004, PHYSIOL REV, V84, P87, DOI 10.1152/physrev.00014.2003
   Madrigal I, 2010, J HUM GENET, V55, P822, DOI 10.1038/jhg.2010.119
   Malenka RC, 1999, SCIENCE, V285, P1870, DOI 10.1126/science.285.5435.1870
   Matsuo N, 2008, SCIENCE, V319, P1104, DOI 10.1126/science.1149967
   McKinney RA, 2010, J PHYSIOL-LONDON, V588, P107, DOI 10.1113/jphysiol.2009.178905
   MORIMOTO T, 1995, NEURON, V15, P689, DOI 10.1016/0896-6273(95)90156-6
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   MUNDIGL O, 1993, J CELL BIOL, V122, P1207, DOI 10.1083/jcb.122.6.1207
   Nakamura N, 2005, J BIOL CHEM, V280, P1561, DOI 10.1074/jbc.M410041200
   Numata M, 1998, J BIOL CHEM, V273, P6951, DOI 10.1074/jbc.273.12.6951
   Ohgaki R, 2008, J BIOL CHEM, V283, P4417, DOI 10.1074/jbc.M705146200
   Park M, 2006, NEURON, V52, P817, DOI 10.1016/j.neuron.2006.09.040
   Park M, 2004, SCIENCE, V305, P1972, DOI 10.1126/science.1102026
   Penzes P, 2011, NAT NEUROSCI, V14, P285, DOI 10.1038/nn.2741
   Petrini EM, 2009, NEURON, V63, P92, DOI 10.1016/j.neuron.2009.05.025
   Prekeris R, 1998, J CELL BIOL, V143, P957, DOI 10.1083/jcb.143.4.957
   Racz B, 2004, NAT NEUROSCI, V7, P917, DOI 10.1038/nn1303
   Rasband W. S., 1997, IMAGEJ
   Richards DA, 2005, P NATL ACAD SCI USA, V102, P6166, DOI 10.1073/pnas.0501881102
   Roche KW, 2001, NAT NEUROSCI, V4, P794, DOI 10.1038/90498
   ROTIN D, 1989, AM J PHYSIOL, V257, pC1158
   SHAHI K, 1993, BRAIN RES, V627, P261, DOI 10.1016/0006-8993(93)90329-L
   Shepherd JD, 2007, ANNU REV CELL DEV BI, V23, P613, DOI 10.1146/annurev.cellbio.23.090506.123516
   Sorra KE, 2000, HIPPOCAMPUS, V10, P501, DOI 10.1002/1098-1063(2000)10:5<501::AID-HIPO1>3.0.CO;2-T
   Spacek J, 1997, J NEUROSCI, V17, P190
   Stromme P, 2011, BRAIN, V134, P3369, DOI 10.1093/brain/awr250
   Suh YH, 2010, NAT NEUROSCI, V13, P338, DOI 10.1038/nn.2488
   TABB JS, 1992, J BIOL CHEM, V267, P15412
   Takahashi Y, 2011, AM J MED GENET B, V156B, P799, DOI 10.1002/ajmg.b.31221
   Tzschach A, 2011, AM J MED GENET A, V155A, P2771, DOI 10.1002/ajmg.a.34230
   Ohgaki R, 2010, MOL BIOL CELL, V21, P1293, DOI 10.1091/mbc.E09-09-0767
   Wang ZP, 2008, CELL, V135, P535, DOI 10.1016/j.cell.2008.09.057
   Weisz OA, 2003, TRAFFIC, V4, P57, DOI 10.1034/j.1600-0854.2003.40201.x
   Wilson JM, 1997, J CELL BIOL, V136, P319, DOI 10.1083/jcb.136.2.319
   Xinhan Lou, 2011, Am J Physiol Cell Physiol, V301, pC1431, DOI 10.1152/ajpcell.00154.2011
   Yoshimori T, 1996, J CELL BIOL, V133, P247, DOI 10.1083/jcb.133.2.247
   Yuste R, 2004, NAT REV NEUROSCI, V5, P24, DOI 10.1038/nrn1300
   Yuste R, 2001, ANNU REV NEUROSCI, V24, P1071, DOI 10.1146/annurev.neuro.24.1.1071
NR 81
TC 10
Z9 10
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD JAN 9
PY 2013
VL 33
IS 2
BP 595
EP 610
DI 10.1523/JNEUROSCI.2583-12.2013
PG 16
WC Neurosciences
SC Neurosciences & Neurology
GA 071EN
UT WOS:000313569600022
PM 23303939
ER

PT J
AU Cardenas-Aguayo, MD
   Kazim, SF
   Grundke-Iqbal, I
   Iqbal, K
AF Cardenas-Aguayo, Maria del Carmen
   Kazim, Syed Faraz
   Grundke-Iqbal, Inge
   Iqbal, Khalid
TI Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse
   Hippocampal Primary Neuronal Cell Cultures
SO PLOS ONE
LA English
DT Article
ID NERVE GROWTH-FACTOR; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; PARTIAL
   AGONISTS; SMALL-MOLECULE; ADULT NEUROGENESIS; DENTATE GYRUS;
   SPINAL-CORD; IN-VITRO; BRAIN
AB The level of brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is down regulated in Alzheimer's disease (AD), Parkinson's disease (PD), depression, stress, and anxiety; conversely the level of this neurotrophin is increased in autism spectrum disorders. Thus, modulating the level of BDNF can be a potential therapeutic approach for nervous system pathologies. In the present study, we designed five different tetra peptides (peptides B-1 to B-5) corresponding to different active regions of BDNF. These tetra peptides were found to be non-toxic, and they induced the expression of neuronal markers in mouse embryonic day 18 (E18) primary hippocampal neuronal cultures. Additionally, peptide B-5 induced the expression of BDNF and its receptor, TrkB, suggesting a positive feedback mechanism. The BDNF peptides induced only a moderate activation (phosphorylation at Tyr 706) of the TrkB receptor, which could be blocked by the Trk's inhibitor, K252a. Peptide B-3, when combined with BDNF, potentiated the survival effect of this neurotrophin on H2O2-treated E18 hippocampal cells. Peptides B-3 and B-5 were found to work as partial agonists and as partial antagonists competing with BDNF to activate the TrkB receptor in a dose-dependent manner. Taken together, these results suggest that the described BDNF tetra peptides are neurotrophic, can modulate BDNF signaling in a partial agonist/antagonist way, and offer a novel therapeutic approach to neural pathologies where BDNF levels are dysregulated.
C1 [Cardenas-Aguayo, Maria del Carmen; Kazim, Syed Faraz; Grundke-Iqbal, Inge; Iqbal, Khalid] New York State Inst Basic Res Dev Disabil, Dept Neurochem, Staten Isl, NY 10314 USA.
   [Kazim, Syed Faraz] Suny Downstate Med Ctr, Neural & Behav Sci Grad Program, Brooklyn, NY 11203 USA.
RP Iqbal, K (reprint author), New York State Inst Basic Res Dev Disabil, Dept Neurochem, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM khalid.iqbal.ibr@gmail.com
FU New York State Office of People with Developmental Disabilities; EVER
   NeuroPharma GmbH, Unterach, Austria
FX Studies described in this article were supported in part by the New York
   State Office of People with Developmental Disabilities, and a research
   grant from EVER NeuroPharma GmbH, Unterach, Austria. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
CR Adessi C, 2002, CURR MED CHEM, V9, P963, DOI 10.2174/0929867024606731
   Ankeny DP, 2001, EXP NEUROL, V170, P85, DOI 10.1006/exnr.2001.7699
   Barkats M, 1998, PROG NEUROBIOL, V55, P333, DOI 10.1016/S0301-0082(98)00028-8
   Barrett GL, 2000, PROG NEUROBIOL, V61, P205, DOI 10.1016/S0301-0082(99)00056-8
   Kasarskis EJ, 1999, NEUROLOGY, V52, P1427
   Beck M, 2005, AMYOTROPH LATERAL SC, V6, P100, DOI 10.1080/14660820510028412
   Behl C, 2002, FREE RADICAL BIO MED, V33, P182, DOI 10.1016/S0891-5849(02)00883-3
   Binder DK, 2004, GROWTH FACTORS, V22, P123, DOI 10.1080/08977190410001723308
   Blanchard J, 2010, ACTA NEUROPATHOL, V120, P605, DOI 10.1007/s00401-010-0734-6
   Blanchard J, 2011, J NEUROPATH EXP NEUR, V70, P1070, DOI 10.1097/NEN.0b013e318236e9ad
   Blanchard J, 2010, J ALZHEIMERS DIS, V21, P1185, DOI [10.3233/JAD-2010-1000069, 10.3233/JAD-2010-100069]
   Bolognin S, 2012, ACTA NEUROPATHOL, V123, P133, DOI 10.1007/s00401-011-0908-x
   BOTHWELL M, 1995, ANNU REV NEUROSCI, V18, P223, DOI 10.1146/annurev.neuro.18.1.223
   Cardenas-Aguayo MD, 2003, J HEMATOTH STEM CELL, V12, P735
   Chao MV, 2002, NEURON, V33, P9, DOI 10.1016/S0896-6273(01)00573-6
   Chao MV, 2003, NAT REV NEUROSCI, V4, P299, DOI 10.1038/nrn1078
   Chohan MO, 2011, NEUROBIOL AGING, V32, P1420, DOI 10.1016/j.neurobiolaging.2009.08.008
   Correia CT, 2010, GENES BRAIN BEHAV, V9, P841, DOI 10.1111/j.1601-183X.2010.00627.x
   Cotman CW, 2002, TRENDS NEUROSCI, V25, P295, DOI 10.1016/S0166-2236(02)02143-4
   Counts SE, 2005, J NEUROPATH EXP NEUR, V64, P263
   Eglen R, 2011, PHARMACOL THERAPEUT, V130, P144, DOI 10.1016/j.pharmthera.2011.01.007
   Fletcher JM, 2009, BIOORGAN MED CHEM, V17, P2695, DOI 10.1016/j.bmc.2009.02.053
   Fryer RH, 1997, EXP NEUROL, V148, P616, DOI 10.1006/exnr.1997.6699
   Fumagalli F, 2006, PHARMACOGENOMICS J, V6, P95, DOI 10.1038/sj.tpj.6500360
   Fumagalli F, 2006, PHARMACOGENOMICS J, V6, P8, DOI 10.1038/sj.tpj.6500337
   Grundke-Iqbal I, 1988, Brain Res, V464, P43
   Haase G, 1998, J NEUROL SCI, V160, pS97, DOI 10.1016/S0022-510X(98)00207-X
   Harper MM, 2009, EXP EYE RES, V89, P538, DOI 10.1016/j.exer.2009.05.013
   HOYER D, 1993, TRENDS PHARMACOL SCI, V14, P270, DOI 10.1016/0165-6147(93)90129-8
   Ji YY, 2005, NAT NEUROSCI, V8, P164, DOI 10.1038/nn1381
   Kaplan DR, 2000, CURR OPIN NEUROBIOL, V10, P381, DOI 10.1016/S0959-4388(00)00092-1
   Lee J, 2000, J MOL NEUROSCI, V15, P99, DOI 10.1385/JMN:15:2:99
   Li B, 2010, FEBS LETT, V584, P3359, DOI 10.1016/j.febslet.2010.06.025
   Li N, 2010, ACTA PHARMACOL SIN, V31, P265, DOI 10.1038/aps.2010.3
   Lieberman JA, 2004, CNS DRUGS, V18, P251, DOI 10.2165/00023210-200418040-00005
   Longo FM, 2004, J ALZHEIMERS DIS, V6, pS13
   Longo FM, 2007, CURR ALZHEIMER RES, V4, P503, DOI 10.2174/156720507783018316
   Lubin FD, 2008, J NEUROSCI, V28, P10576, DOI 10.1523/JNEUROSCI.1786-08.2008
   Ma DK, 2009, SCIENCE, V323, P1074, DOI 10.1126/science.1166859
   Mandel RJ, 2010, CURR OPIN MOL THER, V12, P240
   Manfredsson FP, 2012, NEUROBIOL DIS
   Martinowich K, 2007, NAT NEUROSCI, V10, P1089, DOI 10.1038/nn1971
   Massa F, 2011, P NATL ACAD SCI USA, V108, P6644, DOI 10.1073/pnas.1016928108
   Massa SM, 2010, J CLIN INVEST, V120, P1774, DOI 10.1172/JCI41356
   Matsumoto T, 2008, NAT NEUROSCI, V11, P131, DOI 10.1038/nn2038
   Molina-Holgado F, 2008, CNS NEUROL DISORD-DR, V7, P110
   Nagahara AH, 2011, NAT REV DRUG DISCOV, V10, P209, DOI 10.1038/nrd3366
   Nakagawara A, 2001, CANCER LETT, V169, P107, DOI 10.1016/S0304-3835(01)00530-4
   O'Leary PD, 2003, J BIOL CHEM, V278, P25738, DOI 10.1074/jbc.M303209200
   PHILLIPS HS, 1991, NEURON, V7, P695, DOI 10.1016/0896-6273(91)90273-3
   Price RD, 2007, PHARMACOL THERAPEUT, V115, P292, DOI 10.1016/j.pharmthera.2007.03.005
   Simmons DA, 2009, P NATL ACAD SCI USA, V106, P4906, DOI 10.1073/pnas.0811228106
   Tapia-Arancibia L, 2008, BRAIN RES REV, V59, P201, DOI 10.1016/j.brainresrev.2008.07.007
   Tatebayashi Y, 1999, J NEUROSCI, V19, P5245
   Tsai SJ, 2007, MED HYPOTHESES, V68, P674, DOI 10.1016/j.mehy.2006.06.019
   Tsankova NM, 2006, NAT NEUROSCI, V9, P519, DOI 10.1038/nn1659
   Whitty A, 1999, CHEM BIOL, V6, pR107, DOI 10.1016/S1074-5521(99)80034-9
   Yang JM, 2009, NAT NEUROSCI, V12, P113, DOI 10.1038/nn.2244
   Yang T, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003604
   Young W, 2009, CELL TRANSPLANT, V18, P951, DOI 10.3727/096368909X471251
   Zhang W, 2008, NEUROSCIENCE, V152, P502, DOI 10.1016/j.neuroscience.2007.12.037
NR 61
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 8
PY 2013
VL 8
IS 1
AR e53596
DI 10.1371/journal.pone.0053596
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 069IY
UT WOS:000313429800062
ER

PT J
AU Eapen, V
   Crncec, R
   Walter, A
AF Eapen, Valsamma
   Crncec, Rudi
   Walter, Amelia
TI Clinical outcomes of an early intervention program for preschool
   children with Autism Spectrum Disorder in a community group setting
SO BMC PEDIATRICS
LA English
DT Article
DE Autism; Behavioral intervention; Early intervention; Cognitive function;
   Developmental outcomes
ID INTENSIVE BEHAVIORAL INTERVENTION; SOCIAL COMMUNICATION QUESTIONNAIRE;
   PERVASIVE DEVELOPMENTAL DISORDERS; YOUNG-CHILDREN; STABILITY; CHECKLIST
AB Background: Available evidence indicates that early intervention programs, such as the Early Start Denver Model (ESDM), can positively affect key outcomes for children with Autism Spectrum Disorder (ASD). However, programs involving resource intensive one-to-one clinical intervention are not readily available or deliverable in the community, resulting in many children with ASD missing out on evidence-based intervention during their early and most critical preschool years. This study evaluated the effectiveness of the ESDM for preschool-aged children with ASD using a predominantly group-based intervention in a community child care setting.
   Methods: Participants were 26 children (21 male) with ASD with a mean age of 49.6 months. The ESDM, a comprehensive early intervention program that integrates applied behaviour analysis with developmental and relationship-based approaches, was delivered by trained therapists during the child's attendance at a child care centre for preschool-aged children with ASD. Children received 15-20 hours of group-based, and one hour of one-to-one, ESDM intervention per week. The average intervention period was ten months. Outcome measures were administered pre- and post-intervention, and comprised a developmental assessment - the Mullen Scales of Early Learning (MSEL); and two parent-report questionnaires - the Social Communication Questionnaire (SCQ) and Vineland Adaptive Behaviours Scales-Second Edition (VABS-II).
   Results: Statistically significant post-intervention improvements were found in children's performance on the visual reception, receptive language and expressive language domains of the MSEL in addition to their overall intellectual functioning, as assessed by standardised developmental quotients. Parents reported significant increases in their child's receptive communication and motor skills on the VABS-II, and a significant decrease in autism-specific features on the SCQ. These effects were of around medium size, and appeared to be in excess of what may have been expected due to maturation. Nonetheless, these results need to be confirmed in a controlled study.
   Conclusions: This study suggests community dissemination of the ESDM using predominantly group-based intervention may be an effective intervention. Making the ESDM accessible to the wider ASD community in child care settings has the potential for significant clinical and economic benefits. Further studies are indicated in this area, including those with younger children, and which incorporate a control group and standardised ASD assessments.
C1 [Eapen, Valsamma; Crncec, Rudi; Walter, Amelia] Acad Unit Child Psychiat, South West Sydney Local Hlth Dist AUCS, Sydney, NSW, Australia.
   [Eapen, Valsamma; Crncec, Rudi; Walter, Amelia] Univ New S Wales, Sydney, NSW, Australia.
RP Eapen, V (reprint author), Acad Unit Child Psychiat, South West Sydney Local Hlth Dist AUCS, Sydney, NSW, Australia.
EM v.eapen@unsw.edu.au
FU Australian Government; management of KU Children's Services
FX KU Marcia Burgess Autism Specific Early Learning Childcare Centre in
   Liverpool, Australia, was established by KU Children's Services with the
   University of New South Wales (UNSW) as research partner. The authors
   would like to thank the staff and families who participated in the
   project and in particular Elizabeth Fulton who led the implementation of
   the ESDM curriculum at the centre; Kate Piromalli who assisted in
   setting up and collecting the data in the initial phase of the study;
   Warren Ryan for methodological advice; and Dr Roger Blackmore for his
   assistance with reliability checks and peer support. Prof. Sally Rogers,
   Dr. Laurie Vismara and Dr. Cynthia Zierhut of the MIND Institute UC
   Davis provided assistance with ESDM training and peer support. We would
   like to acknowledge the research funding from the Australian Government
   and the support provided by the management of KU Children's Services in
   conducting this research, especially Pam Macrossan.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Begovac I, 2009, PSYCHIAT DANUB, V21, P310
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d
   Charman T, 2003, INT J LANG COMM DIS, V38, P265, DOI 10.1080/136820310000104830
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
   Dietz C, 2007, EUR CHILD ADOLES PSY, V16, P405, DOI 10.1007/s00787-007-0614-3
   Dunlap WP, 1996, PSYCHOL METHODS, V1, P170, DOI 10.1037//1082-989X.1.2.170
   Eapen V, 2011, CURR OPIN PSYCHIATR, V24, P226, DOI 10.1097/YCO.0b013e328345927e
   Eikeseth S, 2012, RES AUTISM SPECT DIS, V6, P829, DOI 10.1016/j.rasd.2011.09.002
   Eikeseth S, 2002, BEHAV MODIF, V26, P49, DOI 10.1177/0145445502026001004
   Eldevik S, 2012, J AUTISM DEV DISORD, V42, P210, DOI 10.1007/s10803-011-1234-9
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Granpeesheh D, 2009, ANN CLIN PSYCHIATRY, V21, P162
   Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P606, DOI 10.1007/s10803-007-0427-8
   Magiati I, 2007, J CHILD PSYCHOL PSYC, V48, P803, DOI 10.1111/j.1469-7610.2007.01756.x
   Makrygianni MK, 2010, RES AUTISM SPECT DIS, V4, P577, DOI 10.1016/j.rasd.2010.01.014
   Mullen E, 1995, MULLEN SCALES EARLY
   Perry A, 2008, RES AUTISM SPECT DIS, V2, P621, DOI 10.1016/j.rasd.2008.01.002
   Perry A, 2011, RES AUTISM SPECT DIS, V5, P592, DOI 10.1016/j.rasd.2010.07.003
   Reichow B, 2012, J AUTISM DEV DISORD, V42, P512, DOI 10.1007/s10803-011-1218-9
   Rogers S. J., 2009, EARLY START DENVER M
   ROGERS SJ, 1989, J AM ACAD CHILD PSY, V28, P207, DOI 10.1097/00004583-198903000-00010
   ROGERS SJ, 1991, J AM ACAD CHILD PSY, V30, P483, DOI 10.1097/00004583-199105000-00021
   Rutter M., 2003, SOCIAL COMMUNICATION
   SAVILLE DJ, 1990, AM STAT, V44, P174, DOI 10.2307/2684163
   Skuse DH, 2005, BRIT J PSYCHIAT, V187, P568, DOI 10.1192/bjp.187.6.568
   Snow AV, 2008, AUTISM, V12, P627, DOI 10.1177/1362361308097116
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Vismara LA, 2010, ANNU REV CLIN PSYCHO, V6, P447, DOI 10.1146/annurev.clinpsy.121208.131151
   Vivanti G, 2012, J AUTISM DEV DISORD
   Wallace KS, 2010, J CHILD PSYCHOL PSYC, V51, P1300, DOI 10.1111/j.1469-7610.2010.02308.x
NR 35
TC 8
Z9 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD JAN 7
PY 2013
VL 13
AR 3
DI 10.1186/1471-2431-13-3
PG 9
WC Pediatrics
SC Pediatrics
GA 129OQ
UT WOS:000317851300001
PM 23294523
ER

PT J
AU Freitag, CM
   Cholemkery, H
   Elsuni, L
   Kroeger, AK
   Bender, S
   Kunz, CU
   Kieser, M
AF Freitag, Christine M.
   Cholemkery, Hannah
   Elsuni, Leyla
   Kroeger, Anne K.
   Bender, Stephan
   Kunz, Cornelia Ursula
   Kieser, Meinhard
TI The group-based social skills training SOSTA-FRA in children and
   adolescents with high functioning autism spectrum disorder - study
   protocol of the randomised, multi-centre controlled SOSTA - net trial
SO TRIALS
LA English
DT Article
DE Social skills training; Neural function; Moderating factors; Autism
   spectrum disorder
ID PSYCHIATRIC-DISORDERS; ASPERGERS-SYNDROME; INTERVENTION; POPULATION;
   PREVALENCE; EFFICACY; LOCF
AB Background: Group-based social skills training (SST) has repeatedly been recommended as treatment of choice in high-functioning autism spectrum disorder (HFASD). To date, no sufficiently powered randomised controlled trial has been performed to establish efficacy and safety of SST in children and adolescents with HFASD. In this randomised, multi-centre, controlled trial with 220 children and adolescents with HFASD it is hypothesized, that add-on group-based SST using the 12 weeks manualised SOSTA-FRA program will result in improved social responsiveness (measured by the parent rated social responsiveness scale, SRS) compared to treatment as usual (TAU). It is further expected, that parent and self reported anxiety and depressive symptoms will decline and pro-social behaviour will increase in the treatment group. A neurophysiological study in the Frankfurt HFASD subgroup will be performed pre- and post treatment to assess changes in neural function induced by SST versus TAU.
   Methods/design: The SOSTA - net trial is designed as a prospective, randomised, multi-centre, controlled trial with two parallel groups. The primary outcome is change in SRS score directly after the intervention and at 3 months follow-up. Several secondary outcome measures are also obtained. The target sample consists of 220 individuals with ASD, included at the six study centres.
   Discussion: This study is currently one of the largest trials on SST in children and adolescents with HFASD worldwide. Compared to recent randomised controlled studies, our study shows several advantages with regard to in- and exclusion criteria, study methods, and the therapeutic approach chosen, which can be easily implemented in non-university-based clinical settings.
C1 [Freitag, Christine M.; Cholemkery, Hannah; Elsuni, Leyla; Kroeger, Anne K.; Bender, Stephan] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
   [Bender, Stephan] Univ Dresden, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-01307 Dresden, Germany.
   [Kunz, Cornelia Ursula; Kieser, Meinhard] Heidelberg Univ, Inst Med Biometry & Informat, D-69120 Heidelberg, Germany.
RP Freitag, CM (reprint author), Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany.
EM C.Freitag@em.uni-frankfurt.de
FU German Research Foundation DFG (Deutsche Forschungsgemeinschaft
   [FR2069/2-1]
FX We thank the study participants and their parents for taking part in the
   trial. We thoroughly thank all participating centres of the SOSTA-net
   trial for their ongoing commitment and enthusiasm: Professor Dr Beate
   Herpertz-Dahlmann, Department of Child and Adolescent Psychiatry,
   Psychosomatics and Psychotherapy, University Hospital RWTH, Aachen,
   Germany; Professor Dr Alexander von Gontard, Susann Hanig, Department of
   Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy,
   Saarland University Hospital, Homburg/Saar, Germany; Professor Dr Gerd
   Lehmkuhl, Department of Child and Adolescent Psychiatry, Psychosomatics
   and Psychotherapy, Klinikum der Universit zu Koln, Cologne, Germany; Dr
   Louise Poustka, Department of Child and Adolescent Psychiatry,
   Psychosomatics and Psychotherapy, Central Institute of Mental Health,
   Mannheim, Germany, and Dr Regina Taurines, Department of Child and
   Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of
   Wuerzburg, Germany. The trial is supported by grant FR2069/2-1 of the
   German Research Foundation DFG (Deutsche Forschungsgemeinschaft).
CR Arbeitsgruppe Deutsche Child Behavior Checklist, 1999, DTSCH BEARB CHILD BE
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Beaumont R, 2008, J CHILD PSYCHOL PSYC, V49, P743, DOI 10.1111/j.1469-7610.2008.01920.x
   Bolte S., 2008, SKALA ERFASSUNG SOZI
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   DeRosier ME, 2011, J AUTISM DEV DISORD, V41, P1033, DOI 10.1007/s10803-010-1128-2
   Elashoff JD, 2007, NQUERY ADVISOR VERSI
   Frankel F, 2010, J AUTISM DEV DISORD, V40, P827, DOI 10.1007/s10803-009-0932-z
   Herbrecht E, 2009, EUR CHILD ADOLES PSY, V18, P327, DOI 10.1007/s00787-008-0734-4
   Koenig K, 2010, J AUTISM DEV DISORD, V40, P1209, DOI 10.1007/s10803-010-0979-x
   Lane P, 2008, PHARM STAT, V7, P93, DOI 10.1002/pst.267
   Laugeson EA, 2009, J AUTISM DEV DISORD, V39, P596, DOI 10.1007/s10803-008-0664-5
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lopata C, 2010, J AUTISM DEV DISORD, V40, P1297, DOI 10.1007/s10803-010-0989-8
   Mallinckrodt CH, 2008, DRUG INF J, V42, P303
   Maurer M, 1995, BIOMETRIE CHEM PHARM, V6, P3
   Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
   Rothenberger A, 2008, EUR CHILD ADOLES PSY, V17, P99, DOI 10.1007/s00787-008-1011-2
   Siddiqui O, 2009, J BIOPHARM STAT, V19, P227, DOI 10.1080/10543400802609797
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Solomon M, 2004, J AUTISM DEV DISORD, V34, P649, DOI 10.1007/s10803-004-5286-y
   STIENSMEIERPELS.J, 2000, DIKJ DEPRESSIONSINVE
   Tse J, 2007, J AUTISM DEV DISORD, V37, P1960, DOI 10.1007/s10803-006-0343-3
   UNNEWEHR S, 2009, KINDER DIPS DIAGNOST
   White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
NR 26
TC 5
Z9 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JAN 7
PY 2013
VL 14
AR 6
DI 10.1186/1745-6215-14-6
PG 12
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 083WH
UT WOS:000314495400001
PM 23289935
ER

PT J
AU Langridge, AT
   Glasson, EJ
   Nassar, N
   Jacoby, P
   Pennell, C
   Hagan, R
   Bourke, J
   Leonard, H
   Stanley, FJ
AF Langridge, Amanda T.
   Glasson, Emma J.
   Nassar, Natasha
   Jacoby, Peter
   Pennell, Craig
   Hagan, Ronald
   Bourke, Jenny
   Leonard, Helen
   Stanley, Fiona J.
TI Maternal Conditions and Perinatal Characteristics Associated with Autism
   Spectrum Disorder and Intellectual Disability
SO PLOS ONE
LA English
DT Article
ID URINARY-TRACT-INFECTIONS; MENTAL-RETARDATION; RISK-FACTORS;
   WESTERN-AUSTRALIA; OBSTETRIC COMPLICATIONS; DEVELOPMENTAL-DISABILITIES;
   DIAGNOSTIC SUBSTITUTION; HEAD CIRCUMFERENCE; MEDICAL CONDITIONS;
   POPULATION COHORT
AB Background: As well as being highly comorbid conditions, autism spectrum disorders (ASD) and intellectual disability (ID) share a number of clinically-relevant phenomena. This raises questions about similarities and overlap in diagnosis and aetiological pathways that may exist for both conditions.
   Aims: To examine maternal conditions and perinatal factors for children diagnosed with an ASD, with or without ID, and children with ID of unknown cause, compared with unaffected children.
   Methods: The study population comprised all live singleton births in Western Australia (WA) between January 1984 and December 1999 (N = 383,153). Univariate and multivariate multinomial logistic regression models were applied using a blocked modelling approach to assess the effect of maternal conditions, sociodemographic factors, labour and delivery characteristics and neonatal outcomes.
   Results: In univariate analyses mild-moderate ID was associated with pregnancy hypertension, asthma, urinary tract infection, some types of ante-partum haemorrhage, any type of preterm birth, elective C-sections, breech presentation, poor fetal growth and need for resuscitation at birth, with all factors showing an increased risk. Severe ID was positively associated with poor fetal growth and need for resuscitation, as well as any labour or delivery complication. In the multivariate analysis no maternal conditions or perinatal factors were associated with an increased risk of ASD without ID. However, pregnancy hypertension and small head circumference were associated with a reduced risk (OR = 0.64, 95% CI: 0.43, 0.94; OR = 0.58, 95% CI: 0.34, 0.96, respectively). For ASD with ID, threatened abortion before 20 weeks gestation and poor fetal growth were associated with an increased risk.
   Conclusion: Findings show that indicators of a poor intrauterine environment are associated with an elevated risk of ID, while for ASD, and particularly ASD without ID, the associations are much weaker. As such, these findings highlight the importance of accounting for the absence or presence of ID when examining ASD, if we are to improve our understanding of the causal pathways associated with these conditions.
C1 [Langridge, Amanda T.; Glasson, Emma J.; Nassar, Natasha; Jacoby, Peter; Bourke, Jenny; Leonard, Helen; Stanley, Fiona J.] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia.
   [Nassar, Natasha] Univ Sydney, Kolling Inst Med Res, Sydney, NSW 2006, Australia.
   [Hagan, Ronald] Univ Western Australia, Sch Womens & Infants Hlth, Dept Neonatol, Perth, WA 6009, Australia.
RP Langridge, AT (reprint author), Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia.
EM amandal@ichr.uwa.edu.au
RI Glasson, Emma/H-5339-2013; Leonard, Helen/A-1010-2013
OI Glasson, Emma/0000-0003-3996-9049; Leonard, Helen/0000-0001-6405-5834
FU Australian National Health and Medical Research Council (NHMRC)
   [572742]; NHMRC [572568, 632955]
FX Funding was provided by the Australian National Health and Medical
   Research Council (NHMRC, http://www.nhmrc.gov.au) Program Grant
   (572742), NHMRC Research Fellowship (572568 to HL) and NHMRC Career
   Development Fellowship (632955 to NN). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1987, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   [Anonymous], 2001, MEAS REM ACC REM IND
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Berger R, 2002, J SOC GYNECOL INVEST, V9, P319, DOI 10.1016/S1071-5576(02)00164-8
   Bertrand J, 2001, PEDIATRICS, V108, P1155, DOI 10.1542/peds.108.5.1155
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927
   Blair E, 2005, BMC PEDIAT, V5
   Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
   Broman S, 1987, PUBLIC HLTH REP, V102, P55
   BRYSON SE, 1988, J AM ACAD CHILD PSY, V27, P418, DOI 10.1097/00004583-198807000-00006
   Buchmayer S, 2009, PEDIATRICS, V124, pE817, DOI 10.1542/peds.2008-3582
   Burstyn I, 2010, CHRONIC DIS CAN, V30, P125
   Camp BW, 1998, EARLY HUM DEV, V50, P159, DOI 10.1016/S0378-3732(97)00034-9
   Coo H, 2008, J AUTISM DEV DISORD, V38, P1036, DOI 10.1007/s10803-007-0478-x
   Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950
   Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880
   Croen LA, 2005, ARCH PEDIAT ADOL MED, V159, P151, DOI 10.1001/archpedi.159.2.151
   Croen LA, 2011, J NEURODEV DISORD, V3, P307, DOI 10.1007/s11689-011-9093-4
   Croen LA, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.6.e86
   Crowther CA, 2003, JAMA-J AM MED ASSOC, V290, P2669, DOI 10.1001/jama.290.20.2669
   Dammann O, 2002, MENT RETARD DEV D R, V8, P46, DOI 10.1002/mrdd.10005
   Dammann O, 1997, PEDIATR RES, V42, P1, DOI 10.1203/00006450-199707000-00001
   DEYKIN EY, 1980, AM J DIS CHILD, V134, P860
   Drews CD, 1996, PEDIATRICS, V97, P547
   Eaton WW, 2001, J AUTISM DEV DISORD, V31, P279, DOI 10.1023/A:1010743203048
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
   Gardener H, 2011, PERINATAL NEONATAL R
   Gee V, 1994, VALIDATION STUDY W A
   Gillberg C, 2002, DEV MED CHILD NEUROL, V44, P296
   GILLBERG C, 1983, J AUTISM DEV DISORD, V13, P153, DOI 10.1007/BF01531816
   Glasson EJ, 2008, MED J AUSTRALIA, V188, P288
   Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
   HAGBERG B, 1983, BRAIN DEV-JPN, V5, P441
   Hallmayer J, 2011, ARCH GEN PSYCHIAT AR, V2011, P2076
   Heber R, 1961, AM J MENTAL DEFICIEN, V64
   Holman CDJ, 2008, AUST HEALTH REV, V32, P766
   Hornig M, 2001, MENT RETARD DEV D R, V7, P200, DOI 10.1002/mrdd.1028
   Hou JW, 1998, J INTELL DISABIL RES, V42, P137, DOI 10.1046/j.1365-2788.1998.00104.x
   Huleihel Mahmoud, 2004, Reprod Biol Endocrinol, V2, P17, DOI 10.1186/1477-7827-2-17
   Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6
   JONAS O, 1989, EUR J EPIDEMIOL, V5, P322, DOI 10.1007/BF00144832
   Juul-Dam N, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.4.e63
   Kohane IS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033224
   Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
   Leonard H, 2005, SOC SCI MED, V60, P1499, DOI 10.1016/j.socscimed.2004.08.014
   Leonard H, 2008, AM J EPIDEMIOL, V167, P103, DOI 10.1093/aje/kwm245
   Leonard H, 2010, RES AUTISM SPECT DIS, V4, P548, DOI 10.1016/j.rasd.2010.01.003
   Leonard H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017875
   Leonard H, 2006, ANN EPIDEMIOL, V16, P448, DOI 10.1016/j.annepidem.2005.05.002
   Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
   Mann JR, 2010, J AUTISM DEV DISORD, V40, P548, DOI 10.1007/s10803-009-0903-4
   McDermott S, 2001, J FAM PRACTICE, V50, P433
   McDermott S, 2000, OBSTET GYNECOL, V96, P113, DOI 10.1016/S0029-7844(00)00823-1
   McElrath TF, 2008, AM J EPIDEMIOL, V168, P980, DOI 10.1093/aje/kwn202
   MERVIS CA, 1995, PAEDIATR PERINAT EP, V9, P455, DOI 10.1111/j.1365-3016.1995.tb00168.x
   Murphy CC, 1998, MENT RETARD DEV D R, V4, P6, DOI 10.1002/(SICI)1098-2779(1998)4:1<6::AID-MRDD3>3.0.CO;2-P
   Nassar N, 2009, INT J EPIDEMIOL, V38, P1245, DOI 10.1093/ije/dyp260
   O'Roak BJ, 2008, AUTISM RES, V1, P4, DOI 10.1002/aur.3
   Petterson B, 2005, ANN HUM BIOL, V32, P237, DOI 10.1080/03014460500075035
   Pink B, 2006, INFORM PAPER INTRO S
   Pink B., 2008, SOCIOECONOMIC INDEXE
   Rapin I, 1997, NEW ENGL J MED, V337, P97, DOI 10.1056/NEJM199707103370206
   ROELEVELD N, 1992, PREV MED, V21, P110, DOI 10.1016/0091-7435(92)90010-F
   SALONEN JT, 1984, J MENT DEFIC RES, V28, P53
   Schieve LA, 2012, RES DEV DISABIL, V33, P467, DOI 10.1016/j.ridd.2011.10.008
   Shattuck PT, 2006, PEDIATRICS, V117, P1028, DOI 10.1542/peds.2005-1516
   StataCorp, 2009, STAT STAT SOFTW REL
   STREISSGUTH AP, 1990, ALCOHOL CLIN EXP RES, V14, P662, DOI 10.1111/j.1530-0277.1990.tb01224.x
   Stromme P, 2000, DEV MED CHILD NEUROL, V42, P76, DOI 10.1017/S0012162200000165
   Sussmann JE, 2009, BRIT J PSYCHIAT, V194, P224, DOI 10.1192/bjp.bp.106.033134
   TAYLOR DJ, 1985, LANCET, V1, P713
   Tuovinen S, 2011, ANN MED, V15, P15
   VanderWeele TJ, 2012, EPIDEMIOLOGY, V23, P1, DOI 10.1097/EDE.0b013e31823aca5d
   Volkmar FR, 2009, J CHILD PSYCHOL PSYC, V50, P108, DOI 10.1111/j.1469-7610.2008.02010.x
   Whitehouse AJO, 2011, J AUTISM DEV DISORD, V41, P122, DOI 10.1007/s10803-010-1019-6
   Williams K, 2008, CHILD CARE HLTH DEV, V34, P249, DOI 10.1111/j.1365-2214.2007.00796.x
   YearginAllsopp M, 1997, DEV MED CHILD NEUROL, V39, P142
   Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
NR 84
TC 6
Z9 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 7
PY 2013
VL 8
IS 1
AR e50963
DI 10.1371/journal.pone.0050963
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 069IS
UT WOS:000313429100004
PM 23308096
ER

PT J
AU Chen, XY
   Wang, H
   Xue, Y
   Chen, L
AF Chen, Xin-Yi
   Wang, Hua
   Xue, Yan
   Chen, Lei
TI Modulation of paraventricular firing rate by secretin in vivo
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Paraventricular nucleus; Secretin; Single unit recordings
ID BRAIN; PITUITARY; IDENTIFICATION; HYPOTHALAMUS; ACTIVATION; AUTISM;
   SYSTEM; MICE
AB The paraventricular nucleus (PVN) of hypothalamus is a major integrative center in homeostatic control. Morphological studies have revealed a high level of secretin and secretin receptor expression in the PVN. To investigate the direct electrophysiological effects of secretin in the PVN, in vivo extracellular recordings were performed in the present study. In 24 out of the 46 paraventricular neurons, micro-pressure ejection of secretin increased the firing rate from 3.07 +/- 0.43 Hz to 4.86 +/- 0.70 Hz. In another 8 out of the 46 paraventricular neurons, secretin decreased the firing rate from 2.61 +/- 0.46 Hz to 1.41 +/- 0.25 Hz. In the remaining 14 paraventricular neurons, secretin did not alter the firing rate significantly. The present findings provided direct electrophysiological evidence for the possible functions of secretin in the PVN. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Chen, Xin-Yi] Shandong Univ, Sch Med, Dept Physiol, Jinan 250012, Peoples R China.
   [Chen, Lei] Qingdao Univ, Dept Physiol, Fac Med, Qingdao 266071, Shandong, Peoples R China.
   [Wang, Hua] Binzhou Med Coll, Dept Physiol, Binzhou 264000, Peoples R China.
RP Chen, L (reprint author), Qingdao Univ, Dept Physiol, Fac Med, Qingdao 266071, Shandong, Peoples R China.
EM chenleiqd@163.com
FU Undergraduate Science and Technology Innovation Foundation in Shandong
   University [2011475]; National Natural Science Foundation of China
   [31070942, 81200872]
FX This work was supported by the grants from the Undergraduate Science and
   Technology Innovation Foundation in Shandong University (No. 2011475) to
   X.Y. Chen, the National Natural Science Foundation of China (Nos.
   31070942 and 81200872).
CR Bayliss WM, 1902, J PHYSIOL-LONDON, V28, P325
   CHARLTON CG, 1982, PEPTIDES, V3, P565, DOI 10.1016/0196-9781(82)90127-9
   Cheng CYY, 2011, NEUROPSYCHOPHARMACOL, V36, P459, DOI 10.1038/npp.2010.178
   Chu JYS, 2006, ANN NY ACAD SCI, V1070, P196, DOI 10.1196/annals.1317.012
   Chu JYS, 2007, MOL CELL BIOL, V27, P2499, DOI 10.1128/MCB.01088-06
   Chu JYS, 2009, P NATL ACAD SCI USA, V106, P15961, DOI 10.1073/pnas.0903695106
   FREMEAU RT, 1986, J NEUROCHEM, V46, P1947
   FREMEAU RT, 1983, J NEUROSCI, V3, P1620
   JIN HO, 1994, AM J PHYSIOL-GASTR L, V267, pG702
   Marty N, 2007, PHYSIOLOGY, V22, P241, DOI 10.1152/physiol.00010.2007
   MUTT V, 1979, LIFE SCI, V25, P1703, DOI 10.1016/0024-3205(79)90472-7
   ODONOHUE TL, 1981, P NATL ACAD SCI-BIOL, V78, P5221, DOI 10.1073/pnas.78.8.5221
   Paxinos G, 1986, RAT BRAIN STEREOTAXI, V2nd
   PETERSEN H, 1978, AM J PHYSIOL, V234, pE286
   RAYBOULD HE, 1993, AM J PHYSIOL, V265, pG540
   SAMSON WK, 1984, LIFE SCI, V34, P155, DOI 10.1016/0024-3205(84)90586-1
   SOLOMON TE, 1978, AM J PHYSIOL, V235, pE714
   Vaudry D, 2000, PHARMACOL REV, V52, P269
   Welch MG, 2004, CELL MOL NEUROBIOL, V24, P219, DOI 10.1023/B:CEMN.0000018618.59015.a2
   Welch MG, 2003, CELL MOL NEUROBIOL, V23, P817, DOI 10.1023/A:1025013322194
   Xue Y, 2007, EXP NEUROL, V205, P108, DOI 10.1016/j.expneurol.2007.01.031
   Yang B, 2004, AM J PHYSIOL-REG I, V286, pR927, DOI 10.1152/ajpregu.00600.2003
   Yung WH, 2001, J NEUROSCI, V21, P7063
NR 23
TC 0
Z9 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD JAN 4
PY 2013
VL 532
BP 29
EP 32
DI 10.1016/j.neulet.2012.10.055
PG 4
WC Neurosciences
SC Neurosciences & Neurology
GA 076DM
UT WOS:000313936700006
PM 23149133
ER

PT J
AU Sadakata, T
   Shinoda, Y
   Oka, M
   Sekine, Y
   Furuichi, T
AF Sadakata, Tetsushi
   Shinoda, Yo
   Oka, Megumi
   Sekine, Yukiko
   Furuichi, Teiichi
TI Autistic-like behavioral phenotypes in a mouse model with copy number
   variation of the CAPS2/CADPS2 gene
SO FEBS LETTERS
LA English
DT Article
DE Autism; Copy number variation; Social interaction; Anxiety
ID CA2+-DEPENDENT ACTIVATOR; NEUROTROPHIC FACTOR; SPECTRUM DISORDER;
   SECRETION; PROTEIN; MICE; BRAIN; RELEASE; FAMILY; CAPS
AB Ca2+-dependent activator protein for secretion 2 (CAPS2 or CADPS2) facilitates secretion and trafficking of dense-core vesicles. Recent genome-wide association studies of autism have identified several microdeletions due to copy number variation (CNV) in one of the chromosome 7q31.32 alleles on which the locus for CAPS2 is located in autistic patients. To evaluate the biological significance of reducing CAPS2 copy number, we analyzed CAPS2 heterozygous mice. Our present findings suggest that adequate levels of CAPS2 protein are critical for normal brain development and behavior, and that allelic changes due to CNV may contribute to autistic symptoms in combination with deficits in other autism-associated genes. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
C1 [Sadakata, Tetsushi; Oka, Megumi] Gunma Univ, Adv Sci Res Leaders Dev Unit, Gunma 3718511, Japan.
   [Sadakata, Tetsushi; Sekine, Yukiko; Furuichi, Teiichi] RIKEN Brain Sci Inst, Lab Mol Neurogenesis, Wako, Saitama 3510198, Japan.
   [Shinoda, Yo; Furuichi, Teiichi] Tokyo Univ Sci, Dept Appl Biol Sci, Noda, Chiba 2788510, Japan.
   [Sadakata, Tetsushi; Shinoda, Yo; Furuichi, Teiichi] JST CREST, Kawaguchi, Saitama 3320012, Japan.
RP Sadakata, T (reprint author), Gunma Univ, Adv Sci Res Leaders Dev Unit, Gunma 3718511, Japan.
EM sadakata-1024@umin.ac.jp; tfuruichi@rs.tus.ac.jp
FU Japan Foundation for Neuroscience and Mental Health; Naito Foundation;
   Narishige Neuroscience Research Foundation; Uehara Memorial Foundation;
   Yamada Science Foundation; Nakajima Foundation; Mother and Child Health
   Foundation; NOVARTIS Foundation for the Promotion of Science; Hamaguchi
   Foundation for the Advancement of Biochemistry, Scientific Research on
   Innovative Areas "Foundation of Synapse and Neurocircuit Pathology";
   Japan Science and Technology Agency (JST; CREST); Japanese Ministry of
   Education, Culture, Sports, Science and Technology (MEXT) [23110524,
   23700454]; Japan Society for the Promotion of Science (JSPS) [23300137,
   23240062]; Institute of Physical and Chemical Research (RIKEN); Program
   to Disseminate Tenure Tracking System of MEXT
FX We are grateful to Dr. Charles Yokoyama (RIKEN Brain Science Institute)
   for help in improving our manuscript. This study was supported by
   Grants-in-Aid for Scientific Research from Japan Foundation for
   Neuroscience and Mental Health, the Naito Foundation, the Narishige
   Neuroscience Research Foundation, the Uehara Memorial Foundation, the
   Yamada Science Foundation, the Nakajima Foundation, the Mother and Child
   Health Foundation, the NOVARTIS Foundation for the Promotion of Science,
   the Hamaguchi Foundation for the Advancement of Biochemistry, Scientific
   Research on Innovative Areas "Foundation of Synapse and Neurocircuit
   Pathology", the Japan Science and Technology Agency (JST; CREST), the
   Japanese Ministry of Education, Culture, Sports, Science and Technology
   (MEXT; grant numbers 23110524 and 23700454), the Japan Society for the
   Promotion of Science (JSPS; grant numbers 23300137 and 23240062), the
   Institute of Physical and Chemical Research (RIKEN); and the Program to
   Disseminate Tenure Tracking System of MEXT granted to Gunma University.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   American Psychiatric Association, 1994, TASK FORC DSM 4DIAGN
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Berwin B, 1998, NEURON, V21, P137, DOI 10.1016/S0896-6273(00)80521-8
   Bibel M, 2000, GENE DEV, V14, P2919, DOI 10.1101/gad.841400
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
   Cisternas FA, 2003, GENOMICS, V81, P279, DOI 10.1016/S0888-7543(02)00040-X
   Dean C, 2009, NAT NEUROSCI, V12, P767, DOI 10.1038/nn.2315
   Dulawa SC, 1999, J NEUROSCI, V19, P9550
   Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559
   Palferman S, 2001, HUM MOL GENET, V10, P973
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Lessmann V, 2003, PROG NEUROBIOL, V69, P341, DOI 10.1016/S0301-0082(03)00019-4
   Lu B, 2003, LEARN MEMORY, V10, P86, DOI 10.1101/lm.54603
   Matsuda N, 2009, J NEUROSCI, V29, P14185, DOI 10.1523/JNEUROSCI.1863-09.2009
   MONTGOMERY KC, 1955, J COMP PHYSIOL PSYCH, V48, P254, DOI 10.1037/h0043788
   Mowla SJ, 1999, J NEUROSCI, V19, P2069
   Muhle R., 2004, PEDIATRICS, V113, P472
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Renden R, 2001, NEURON, V31, P421, DOI 10.1016/S0896-6273(01)00382-8
   Sadakata T, 2004, J NEUROSCI, V24, P43, DOI 10.1523/JNEUROSCI.2528-03.2004
   Sadakata T, 2010, J BIOL CHEM, V285, P38710, DOI 10.1074/jbc.M110.137414
   Sadakata T, 2007, J CLIN INVEST, V117, P931, DOI 10.1172/JCI29031
   Sadakata T, 2009, CEREBELLUM, V8, P312, DOI 10.1007/s12311-009-0097-5
   Sadakata T, 2006, J COMP NEUROL, V495, P735, DOI 10.1002/cne.20947
   Sato Y, 2004, J NEUROSCI METH, V137, P111, DOI 10.1016/j.jneumeth.2004.02.014
   Shinoda Y., 2002, P NATL ACAD SCI USA, V108, P373
   Speidel D, 2003, J BIOL CHEM, V278, P52802, DOI 10.1074/jbc.M304727200
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Tandon A, 1998, NEURON, V21, P147, DOI 10.1016/S0896-6273(00)80522-X
   Tomemori Y, 2005, J NEUROCHEM, V92, P759, DOI 10.1111/j.1471-4159.2004.02924.x
   UCHIHASHI Y, 1994, PROG NEURO-PSYCHOPH, V18, P397
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   World Health Organisation, 1992, ICD 10 CLASS MENT BE
   Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
NR 38
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-5793
J9 FEBS LETT
JI FEBS Lett.
PD JAN 4
PY 2013
VL 587
IS 1
BP 54
EP 59
DI 10.1016/j.febslet.2012.10.047
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 063RC
UT WOS:000313016600009
PM 23159942
ER

PT J
AU Whiteley, P
   Shattock, P
   Knivsberg, AM
   Seim, A
   Reichelt, KL
   Todd, L
   Carr, K
   Hooper, M
AF Whiteley, Paul
   Shattock, Paul
   Knivsberg, Ann-Mari
   Seim, Anders
   Reichelt, Karl L.
   Todd, Lynda
   Carr, Kevin
   Hooper, Malcolm
TI Gluten- and casein-free dietary intervention for autism spectrum
   conditions
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Review
DE autism; brain; gastrointestinal; gluten; casein; diet; intervention;
   intestinal permeability
ID PERVASIVE DEVELOPMENTAL DISORDERS; CELIAC-DISEASE; INTESTINAL
   PERMEABILITY; GASTROINTESTINAL SYMPTOMS; ASPERGER-SYNDROME;
   CONTROLLED-TRIAL; YOUNG-CHILDREN; EPILEPSY; BLIND; AGE
AB Dietary intervention as a tool for maintaining and improving physical health and wellbeing is a widely researched and discussed topic. Speculation that diet may similarly affect mental health and wellbeing particularly in cases of psychiatric and behavioral symptomatology opens up various avenues for potentially improving quality of life. We examine evidence suggestive that a gluten-free (GF), casein-free (CF), or gluten- and casein-free diet (GFCF) can ameliorate core and peripheral symptoms and improve developmental outcome in some cases of autism spectrum conditions. Although not wholly affirmative, the majority of published studies indicate statistically significant positive changes to symptom presentation following dietary intervention. In particular, changes to areas of communication, attention, and hyperactivity are detailed, despite the presence of various methodological shortcomings. Specific characteristics of best- and non-responders to intervention have not been fully elucidated; neither has the precise mode of action for any universal effect outside of known individual cases of food-related co-morbidity. With the publication of controlled medium- and long-term group studies of a gluten- and casein-free diet alongside more consolidated biological findings potentially linked to intervention, the appearance of a possible diet-related autism phenotype seems to be emerging supportive of a positive dietary effect in some cases. Further debate on whether such dietary intervention should form part of best practice guidelines for autism spectrum conditions (ASCs) and onward representative of an autism dietary-sensitive enteropathy is warranted.
C1 [Whiteley, Paul; Shattock, Paul; Todd, Lynda; Carr, Kevin; Hooper, Malcolm] ESPA Res, Robert Luff Lab, Unit Business & Innovat Ctr 133I, Sunderland SR5 2TA, England.
   [Knivsberg, Ann-Mari] Univ Stavanger, Natl Ctr Reading Educ & Res, Stavanger, Norway.
   [Reichelt, Karl L.] Univ Oslo, Rikshosp, Med Ctr, Dept Pediat Res, N-0027 Oslo, Norway.
RP Whiteley, P (reprint author), ESPA Res, Robert Luff Lab, Unit Business & Innovat Ctr 133I, Sunderland Enterprise Pk, Sunderland SR5 2TA, England.
EM paul.whiteley@espa-research.org.uk
FU ESPA; Robert Luff Foundation [273810]
FX This review was fully funded by ESPA Research using part of a donation
   from the Robert Luff Foundation(charity number: 273810). The Foundation
   played no role in the content, formulation or conclusions reached of the
   manuscript.
CR Adams JB, 2011, BMC PEDIATR, V11, DOI 10.1186/1471-2431-11-111
   Afzal N, 2003, PEDIATRICS, V112, P939, DOI 10.1542/peds.112.4.939
   Arnold GL, 2003, J AUTISM DEV DISORD, V33, P449, DOI 10.1023/A:1025071014191
   Ashwood P, 2003, J CLIN IMMUNOL, V23, P504, DOI 10.1023/B:JOCI.0000010427.05143.bb
   ASPERGER H, 1961, ANN PAEDIATR-BASEL, V197, P346
   Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators, 2012, MMWR-MORBID MORTAL W, V61, P1
   Baieli S, 2003, J AUTISM DEV DISORD, V33, P201, DOI 10.1023/A:1022999712639
   Barcia G, 2008, J AUTISM DEV DISORD, V38, P407, DOI 10.1007/s10803-007-0480-3
   Biesiekierski JR, 2011, AM J GASTROENTEROL, V106, P508, DOI 10.1038/ajg.2010.487
   Boukthir Samir, 2010, Tunis Med, V88, P685
   Bowling FG, 2013, BIOCHEM GENET, V51, P147, DOI 10.1007/s10528-012-9550-0
   Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
   Cass H, 2008, ARCH DIS CHILD, V93, P745, DOI 10.1136/adc.2006.114389
   Visser S. N., 2010, Morbidity and Mortality Weekly Report, V59, P1439
   Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
   CLARK JH, 1993, JPEN-PARENTER ENTER, V17, P284, DOI 10.1177/0148607193017003284
   Clayton TA, 2012, FEBS LETT, V586, P956, DOI 10.1016/j.febslet.2012.01.049
   COOK JD, 1991, AM J CLIN NUTR, V53, P106
   Cornish E, 2002, J HUM NUTR DIET, V15, P261, DOI 10.1046/j.1365-277X.2002.00372.x
   CUMMINS AG, 1991, J GASTROEN HEPATOL, V6, P53, DOI 10.1111/j.1440-1746.1991.tb01145.x
   Curtin C, 2010, BMC PEDIATR, V10, DOI 10.1186/1471-2431-10-11
   Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
   de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
   De Santis A, 1997, J INTERN MED, V242, P421, DOI 10.1046/j.1365-2796.1997.00200.x
   DEufemia P, 1996, ACTA PAEDIATR, V85, P1076, DOI 10.1111/j.1651-2227.1996.tb14220.x
   DOHAN FC, 1969, BRIT J PSYCHIAT, V115, P595, DOI 10.1192/bjp.115.522.595
   Elder JH, 2006, J AUTISM DEV DISORD, V36, P413, DOI 10.1007/s10803-006-0079-0
   Evangeliou A, 2003, J CHILD NEUROL, V18, P113, DOI 10.1177/08830738030180020501
   Fasano A, 2012, CLIN GASTROENTEROL H, V10, P1096, DOI 10.1016/j.cgh.2012.08.012
   Fountain C, 2012, PEDIATRICS, V129, pE1112, DOI 10.1542/peds.2011-1601
   Francis K, 2005, DEV MED CHILD NEUROL, V47, P493, DOI 10.1017/S0012162205000952
   Genuis SJ, 2010, J CHILD NEUROL, V25, P114, DOI 10.1177/0883073809336127
   Grafodatskaya D, 2010, J AM ACAD CHILD PSY, V49, P794, DOI 10.1016/j.jaac.2010.05.005
   Hediger ML, 2008, J AUTISM DEV DISORD, V38, P848, DOI 10.1007/s10803-007-0453-6
   Herndon AC, 2009, J AUTISM DEV DISORD, V39, P212, DOI 10.1007/s10803-008-0606-2
   Hsu Chia-Lin, 2009, Chang Gung Med J, V32, P459
   Johnson CR, 2011, J DEV PHYS DISABIL, V23, P213, DOI 10.1007/s10882-010-9217-x
   Jyonouchi H, 2002, NEUROPSYCHOBIOLOGY, V46, P76, DOI 10.1159/000065416
   Kalyva E, 2009, J AUTISM DEV DISORD, V39, P480, DOI 10.1007/s10803-008-0648-5
   Kanner L, 1943, NERV CHILD, V2, P217
   Klei L, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-9
   Knivsberg AM, 2001, NUTR NEUROSCI, V4, P25
   Knivsberg AM, 1995, SCAND J EDUC RES, V39, P223, DOI 10.1080/0031383950390304
   KNIVSBERG A-M, 1990, Brain Dysfunction, V3, P315
   Knivsberg AM, 2002, NUTR NEUROSCI, V5, P251, DOI 10.1080/10281450290028945
   Kost NV, 2009, PEPTIDES, V30, P1854, DOI 10.1016/j.peptides.2009.06.025
   Kushak RI, 2011, AUTISM, V15, P285, DOI 10.1177/1362361310369142
   Latif A, 2002, AUTISM, V6, P103, DOI 10.1177/1362361302006001008
   Lee PR, 2011, EPILEPSY BEHAV, V21, P115, DOI 10.1016/j.yebeh.2011.03.008
   Lucarelli S, 1995, PANMINERVA MED, V37, P137
   Mariani P, 1998, J PEDIATR GASTR NUTR, V27, P519, DOI 10.1097/00005176-199811000-00004
   Martins Y, 2008, J AUTISM DEV DISORD, V38, P1878, DOI 10.1007/s10803-008-0583-5
   Mattila ML, 2011, J AM ACAD CHILD PSY, V50, P583, DOI 10.1016/j.jaac.2011.04.001
   Millward C, 2008, COCHRANE DB SYST REV, V2, DOI DOI 10.1002/14651858.CD003498.PUB3
   Mulloy A, 2010, RES AUTISM SPECT DIS, V4, P328, DOI 10.1016/j.rasd.2009.10.008
   Mulloy A, 2011, RES AUTISM SPECT DIS, V5, P86, DOI 10.1016/j.rasd.2010.07.004
   Neumeyer AM, 2013, J AUTISM DEV DISORD, V43, P1623, DOI 10.1007/s10803-012-1709-3
   Niederhofer H., 2011, PRIM CARE COMPANION, V13
   Nordahl CW, 2011, P NATL ACAD SCI USA, V108, P20195, DOI 10.1073/pnas.1107560108
   Novarino G, 2012, SCIENCE, V338, P394, DOI 10.1126/science.1224631
   Adams S. J., 2008, Journal of Human Nutrition and Dietetics, V21, P374, DOI 10.1111/j.1365-277X.2008.00881_2.x
   Oberman LM, 2012, EXPERT OPIN INV DRUG, V21, P1819, DOI 10.1517/13543784.2012.729819
   Parracho HMRT, 2005, J MED MICROBIOL, V54, P987, DOI 10.1099/jmm.0.46101-0
   Pavone L, 1997, BIOL PSYCHIAT, V42, P72, DOI 10.1016/S0006-3223(97)00267-9
   Pelsser LM, 2011, LANCET, V377, P494, DOI 10.1016/S0140-6736(10)62227-1
   Pennesi CM, 2012, NUTR NEUROSCI, V15, P85, DOI 10.1179/1476830512Y.0000000003
   Perrin James M, 2012, Pediatrics, V130 Suppl 2, pS77, DOI 10.1542/peds.2012-0900E
   Pratesi R, 2003, ACTA NEUROL SCAND, V108, P290, DOI 10.1046/j.1600-0404.2003.00082.x
   Reichelt Karl L., 2012, Microbial Ecology in Health and Disease, V23, P18958, DOI 10.3402/mehd.v23i0.18958
   Robertson MA, 2008, J AUTISM DEV DISORD, V38, P1066, DOI 10.1007/s10803-007-0482-1
   Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
   SEIM AR, 1995, MED HYPOTHESES, V45, P498, DOI 10.1016/0306-9877(95)90230-9
   Severance EG, 2012, SCHIZOPHR RES, V138, P48, DOI 10.1016/j.schres.2012.02.025
   Severance EG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050991
   Shattock Paul, 2002, Expert Opin Ther Targets, V6, P175
   Steffenburg S, 2003, DEV MED CHILD NEUROL, V45, P724, DOI 10.1017/S0012162203001361
   Stewart C, 2008, CHILD CARE HLTH DEV, V34, P276, DOI 10.1111/j.1365-2214.2007.00806.x
   Sun Z, 1999, AUTISM, V3, P67, DOI 10.1177/1362361399003001006
   Sun Z., 1999, AUTISM, V3, P85, DOI 10.1177/1362361399003001007
   Tomchek SD, 2007, AM J OCCUP THER, V61, P190
   Vojdani A, 2004, NUTR NEUROSCI, V7, P151, DOI 10.1080/10284150400004155
   Volkmar FR, 2004, J CHILD PSYCHOL PSYC, V45, P135, DOI 10.1046/j.0021-9630.2003.00317.x
   Wang L, 2009, BIOMARKERS, V14, P596, DOI 10.3109/13547500903183962
   Weintraub K, 2011, NATURE, V479, P22, DOI 10.1038/479022a
   Whiteley P, 1999, AUTISM, V3, P45, DOI 10.1177/1362361399003001005
   Whiteley P, 2010, NUTR NEUROSCI, V13, P87, DOI 10.1179/147683010X12611460763922
   Whiteley P., 2010, AUTISM INSIGHTS, V2, P1
   Whiteley P, 2010, AUTISM INSIGHTS, V2, P39
   Whiteley P, 2004, PEDIATR INT, V46, P531, DOI 10.1111/j.1442-200x.2004.01946.x
   Whyatt CP, 2012, J AUTISM DEV DISORD, V42, P1799, DOI 10.1007/s10803-011-1421-8
   Williams BL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024585
   Williams BL, 2012, MBIO, V3, DOI 10.1128/mBio.00261-11
   World Health Organization, 1992, 10 REV INT CLASS DIS
NR 93
TC 5
Z9 5
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD JAN 4
PY 2013
VL 6
AR 344
DI 10.3389/fnhum.2012.00344
PG 8
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 066IT
UT WOS:000313214800001
ER

PT J
AU Lee, K
   Kim, Y
   Lee, SJ
   Qiang, Y
   Lee, D
   Lee, HW
   Kim, H
   Je, HS
   Sudhof, TC
   Ko, J
AF Lee, Kangduk
   Kim, Yoonji
   Lee, Sung-Jin
   Qiang, Yuan
   Lee, Dongmin
   Lee, Hyun Woo
   Kim, Hyun
   Je, H. Shawn
   Suedhof, Thomas C.
   Ko, Jaewon
TI MDGAs interact selectively with neuroligin-2 but not other neuroligins
   to regulate inhibitory synapse development
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE inhibitory synapse formation; synaptic cell adhesion; autism;
   schizophrenia
ID CELL-ADHESION MOLECULES; IMMUNOGLOBULIN SUPERFAMILY; NEUREXIN BINDING;
   IN-VIVO; NEURONS; COMPLEX; PROTEIN; AUTISM; GENE; SCHIZOPHRENIA
AB The MAM domain-containing GPI anchor proteins MDGA1 and MDGA2 are Ig superfamily adhesion molecules composed of six IG domains, a fibronectin III domain, a MAM domain, and a GPI anchor. MDGAs contribute to the radial migration and positioning of a subset of cortical neurons during early neural development. However, MDGAs continue to be expressed in postnatal brain, and their functions during postnatal neural development remain unknown. Here, we demonstrate that MDGAs specifically and with a nanomolar affinity bind to neuroligin-2, a cell-adhesion molecule of inhibitory synapses, but do not bind detectably to neuroligin-1 or neuroligin-3. We observed no cell adhesion between cells expressing neuroligin-2 and MDGA1, suggesting a cis interaction. Importantly, RNAi-mediated knockdown of MDGAs increased the abundance of inhibitory but not excitatory synapses in a neuroligin-2-dependent manner. Conversely, overexpression of MDGA1 decreased the numbers of functional inhibitory synapses. Likewise, coexpression of both MDGA1 and neuroligin-2 reduced the synaptogenic capacity of neuroligin-2 in an artificial synapse-formation assay by abolishing the ability of neuroligin-2 to form an adhesion complex with neurexins. Taken together, our data suggest that MDGAs inhibit the activity of neuroligin-2 in controlling the function of inhibitory synapses and that MDGAs do so by binding to neuroligin-2.
C1 [Lee, Kangduk; Kim, Yoonji; Ko, Jaewon] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biochem, Seoul 120749, South Korea.
   [Lee, Sung-Jin; Suedhof, Thomas C.] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA.
   [Suedhof, Thomas C.] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA.
   [Qiang, Yuan; Je, H. Shawn] DUKE Natl Univ Singapore Grad Med Sch, Program Neurosci & Behav Disorders, Singapore 169857, Singapore.
   [Lee, Dongmin; Lee, Hyun Woo; Kim, Hyun] Korea Univ, Coll Med, Dept Anat & Neurosci, Seoul 136705, South Korea.
   [Je, H. Shawn] Natl Univ Singapore, Dept Physiol, Singapore 117597, Singapore.
RP Ko, J (reprint author), Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biochem, Seoul 120749, South Korea.
EM jaewonko@yonsei.ac.kr
FU TJ Park Junior Faculty Fellowship from the POSCO TJ Foundation; National
   Research Foundation of Korea [2011-0028337]; Simons Foundation [177850];
   Singapore National Medical Research Council; Singapore Ministry of
   Education; Korea Science and Engineering Foundation [2012-0005820]
FX We thank Drs. Eunjoon Kim (KAIST, Korea) and Dennis O'Leary (The Salk
   Institute) for the kind gifts of reagents and Dr. Ji Won Um (Yale
   University) for the critical comments on the manuscript. This work was
   supported by a TJ Park Junior Faculty Fellowship from the POSCO TJ
   Foundation (to J.K.) and by Grant 2011-0028337 from the National
   Research Foundation of Korea (to J.K.), Grant 177850 from the Simons
   Foundation (to T. C. S.), grants from the Singapore National Medical
   Research Council (to H.S.J.) and from the Singapore Ministry of
   Education (to H.S.J.), and Grant 2012-0005820 from the Korea Science and
   Engineering Foundation (to H.K.).
CR Arac D, 2007, NEURON, V56, P992, DOI 10.1016/j.neuron.2007.12.002
   Boucard AA, 2005, NEURON, V48, P229, DOI 10.1016/j.neuron.2005.08.026
   Boucard AA, 2012, J BIOL CHEM, V287, P9399, DOI 10.1074/jbc.M111.318659
   Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
   Chih B, 2006, NEURON, V51, P171, DOI 10.1016/j.neuron.2006.06.005
   Chubykin AA, 2007, NEURON, V54, P919, DOI 10.1016/j.neuron.2007.05.029
   Chubykin AA, 2005, J BIOL CHEM, V280, P22365, DOI 10.1074/jbc.M410723200
   De Juan C, 2002, ONCOGENE, V21, P3089, DOI 10.1038/sj/onc/1205383
   de Wit J, 2009, NEURON, V64, P799, DOI 10.1016/j.neuron.2009.12.019
   Dityatev A, 2008, NEURON GLIA BIOL, V4, P197, DOI 10.1017/S1740925X09990111
   Gibson JR, 2009, J NEUROSCI, V29, P13883, DOI 10.1523/JNEUROSCI.2457-09.2009
   Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
   Ichtchenko K, 1996, J BIOL CHEM, V271, P2676
   Ishikawa T, 2011, DEV DYNAM, V240, P96, DOI 10.1002/dvdy.22496
   Jedlicka P, 2011, CEREB CORTEX, V21, P357, DOI 10.1093/cercor/bhq100
   Joset P, 2011, NEURAL DEV, V6, DOI 10.1186/1749-8104-6-22
   Kahler AK, 2008, AM J MED GENET B, V147B, P1089, DOI 10.1002/ajmg.b.30726
   Katidou Markella, 2008, Biotechnology Journal, V3, P1564, DOI 10.1002/biot.200800281
   Ko J, 2011, J CELL BIOL, V194, P323, DOI 10.1083/jcb.201101072
   Ko J, 2012, MOL CELLS, V34, P335, DOI 10.1007/s10059-012-0113-3
   Ko J, 2009, EMBO J, V28, P3244, DOI 10.1038/emboj.2009.249
   Ko J, 2009, NEURON, V64, P791, DOI 10.1016/j.neuron.2009.12.012
   Krueger DD, 2012, CURR OPIN NEUROBIOL, V22, P412, DOI 10.1016/j.conb.2012.02.012
   Li JY, 2011, SCHIZOPHR RES, V125, P194, DOI 10.1016/j.schres.2010.11.002
   Lim SH, 2009, EMBO J, V28, P3564, DOI 10.1038/emboj.2009.289
   Lips ES, 2012, MOL PSYCHIATR, V17, P996, DOI 10.1038/mp.2011.117
   Litwack ED, 2004, MOL CELL NEUROSCI, V25, P263, DOI 10.1016/j.mcn.2003.10.016
   Margolis SS, 2010, CELL, V143, P442, DOI 10.1016/j.cell.2010.09.038
   Matsuda K, 2011, EUR J NEUROSCI, V33, P1447, DOI 10.1111/j.1460-9568.2011.07638.x
   Missler M, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005694
   Patel MR, 2009, SCIENCE, V323, P1500, DOI 10.1126/science.1169025
   Poulopoulos A, 2009, NEURON, V63, P628, DOI 10.1016/j.neuron.2009.08.023
   Scheiffele P, 2000, CELL, V101, P657, DOI 10.1016/S0092-8674(00)80877-6
   Soler-Llavina GJ, 2011, P NATL ACAD SCI USA, V108, P16502, DOI 10.1073/pnas.1114028108
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   Takeuchi A, 2006, J NEUROSCI, V26, P4460, DOI 10.1523/JNEUROSCI.4935-05.2006
   Takeuchi A, 2007, CEREB CORTEX, V17, P1531, DOI 10.1093/cercor/bhl064
   Taniguchi H, 2007, J NEUROSCI, V27, P2815, DOI 10.1523/JNEUROSCI.0032-07.2007
   Uemura T, 2010, CELL, V141, P1068, DOI 10.1016/j.cell.2010.04.035
   Varoqueaux F, 2006, NEURON, V51, P741, DOI 10.1016/j.neuron.2006.09.003
   Varoqueaux F, 2004, EUR J CELL BIOL, V83, P449, DOI 10.1078/0171-9335-00410
   Wills ZP, 2012, NEURON, V73, P466, DOI 10.1016/j.neuron.2011.11.029
   Xu JY, 2010, NAT NEUROSCI, V13, P22, DOI 10.1038/nn.2459
NR 44
TC 11
Z9 16
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JAN 2
PY 2013
VL 110
IS 1
BP 336
EP 341
DI 10.1073/pnas.1219987110
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 071XI
UT WOS:000313630300073
PM 23248271
ER

PT J
AU AlHorany, AK
   Younis, NA
   Bataineh, MZ
   Hassan, SA
AF AlHorany, Ahmed Kamel
   Younis, Najati Ahmad
   Bataineh, Marwan Zaid
   Hassan, Siti Aishah
TI Do Mothers of Children with Autism are at Higher Risk of Depression? A
   Systematic Review of Literature
SO LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION
LA English
DT Article
AB We aimed to systematically review studies that examine factors affecting depression among parents of children with disabilities, especially, the autistic children. Besides, we emphasized the effects of gender on depression among the parents. There were at least 27 articles reviewed. The related journal articles on factor affecting depression were downloaded with cut off limit from 1997 to 2013. The articles were then analyzed and organized according to the definitions of depression and various factor affecting depression. We found there was no conclusive evidence regarding the factors affecting the depression among parents of children with autism. There was conclusive evidence from the reviewed literature regarding gender effect, yet the number of article supporting it was small. Mothers of children with autism were more affected in the depression as compared to fathers. Finally, with conclusion we then suggest for future interventional study.
C1 [AlHorany, Ahmed Kamel; Hassan, Siti Aishah] Univ PutraMalaysia UPM, Fac Educ Studies, Dept Counselor Educ & Counseling Psychol, Upm Serdang 43400, Selangor Darul, Malaysia.
RP Hassan, SA (reprint author), Univ PutraMalaysia UPM, Fac Educ Studies, Dept Counselor Educ & Counseling Psychol, Upm Serdang 43400, Selangor Darul, Malaysia.
EM ah_horany2002@yahoo.com; najati_yunis@yahoo.com; marwanzaid76@yahoo.com;
   siti_aishahh@putra.upm.edu.my
NR 0
TC 0
Z9 0
PU MARSLAND PRESS
PI LANSING
PA PO BOX 21126, LANSING, MI 48909 USA
SN 1097-8135
J9 LIFE SCI J
JI Life Sci. J.
PY 2013
VL 10
IS 1
BP 3303
EP 3308
PG 6
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA 199MR
UT WOS:000322999200197
ER

PT J
AU Manti, E
   Scholte, EM
   Van Berckelaer-Onnes, IA
AF Manti, Eirini
   Scholte, Evert M.
   Van Berckelaer-Onnes, Ina A.
TI Exploration of teaching strategies that stimulate the growth of academic
   skills of children with ASD in special education school
SO EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
LA English
DT Article
DE autism spectrum disorders (ASD); cognition; academic growth; special
   needs education; teaching strategies; treatment factors
ID FOLLOW-UP; YOUNG-CHILDREN; AUTISTIC-CHILDREN; ATTACHMENT; OUTCOMES;
   DISORDER; INTERVENTION; PREDICTORS; BEHAVIOR
AB The cognitive growth of children with developmental disorders, like autism, can be seriously impaired due to the disorder. If so, in the Netherlands, these children can attend special schools where they are treated to ameliorate disorder symptoms and to stimulate cognitive growth. The aim of this paper was to identify teaching strategies that stimulate the growth of academic skills in children diagnosed with autism, attending a special needs education school in the Netherlands. Findings showed that the strongest underlying teaching strategy that predicted the academic growth of the children on the autism spectrum in the short and long term was the provision of structure in place, time and activities. It was further found that long-term academic gains were partly predicted by the emotional support from their teachers. The implications of the findings are discussed.
C1 [Manti, Eirini; Scholte, Evert M.; Van Berckelaer-Onnes, Ina A.] Leiden Univ, Dept Clin Child & Adolescence Studies, Leiden, Netherlands.
RP Scholte, EM (reprint author), Leiden Univ, Dept Clin Child & Adolescence Studies, Leiden, Netherlands.
EM scholte@fsw.leidenuniv.nl
CR American Psychiatric Association, 2001, DIAGN STAT MAN MENT, V4th
   Battistich V, 2004, J PRIM PREV, V24, P243, DOI [10.1023/B:J0PP.0000018048.38517.cd, DOI 10.1023/B:JOPP.0000018048.38517.CD]
   Birch SH, 1997, J SCHOOL PSYCHOL, V35, P61, DOI 10.1016/S0022-4405(96)00029-5
   Bowlby J., 1969, ATTACHMENT LOSS
   Campbell M, 1996, J AM ACAD CHILD PSY, V35, P134, DOI 10.1097/00004583-199602000-00005
   CAPPS L, 1994, DEV PSYCHOPATHOL, V6, P249, DOI 10.1017/S0954579400004569
   Charman T, 2004, AUTISM, V8, P89, DOI 10.1177/1362361304040641
   Dissanayake C, 1996, J CHILD PSYCHOL PSYC, V37, P149, DOI 10.1111/j.1469-7610.1996.tb01386.x
   Downs A, 2004, J AUTISM DEV DISORD, V34, P625, DOI 10.1007/s10803-004-5284-0
   Driessen G, 2008, EUR SOCIOL REV, V24, P527, DOI 10.1093/esr/jcn018
   Field A., 2005, DISCOVERING STAT USI, V2nd
   Hamre BK, 2001, CHILD DEV, V72, P625, DOI 10.1111/1467-8624.00301
   Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
   Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
   Howlin P, 2008, CAMBRIDGE TEXTBOOK OF EFFECTIVE TREATMENTS IN PSYCHIATRY, P775, DOI 10.1017/CBO9780511544392.054
   Klem AM, 2004, J SCHOOL HEALTH, V74, P262
   Kline P, 1999, HDB PSYCHOL TESTING
   VENTER A, 1992, J CHILD PSYCHOL PSYC, V33, P489, DOI 10.1111/j.1469-7610.1992.tb00887.x
   Lord C., 2006, CHILD ADOL PSYCH CL, P636
   Luyster R, 2007, J SPEECH LANG HEAR R, V50, P667, DOI 10.1044/1092-4388(2007/047)
   Manti E, 2011, EUR J SPEC NEEDS EDU, V26, P411, DOI 10.1080/08856257.2011.597172
   Mawhood L, 2000, J CHILD PSYCHOL PSYC, V41, P547, DOI 10.1017/S002196309900579X
   McGee GG, 1997, J AUTISM DEV DISORD, V27, P353, DOI 10.1023/A:1025849220209
   Mesibov G. B., 1997, AUTISM UNDERSTANDING, P65
   Miles J., 2001, APPL REGRESSION CORR
   National Research Council, 2001, ED CHILDR AUT
   Noland R., 2007, GROWING AUTISM WORKI, P205
   Nordin V, 1998, ACTA PSYCHIAT SCAND, V97, P99, DOI 10.1111/j.1600-0447.1998.tb09970.x
   Olley J. G., 2005, HDB AUTISM PERVASIVE, P834
   Ozonoff S, 1998, J AUTISM DEV DISORD, V28, P25, DOI 10.1023/A:1026006818310
   Quill K. A., 1995, TEACHING CHILDREN AU
   ROGERS SJ, 1991, J AM ACAD CHILD PSY, V30, P483, DOI 10.1097/00004583-199105000-00021
   Rogers SJ, 1998, J CLIN CHILD PSYCHOL, V27, P168, DOI 10.1207/s15374424jccp2702_4
   Rutgers AH, 2004, J CHILD PSYCHOL PSYC, V45, P1123, DOI 10.1111/j.1469-7610.2004.t01-1-00305.x
   Rutter M., 1979, CONGENITAL ACQUIRED, P247
   Rutter M., 1978, AUTISM REAPPRAISAL C, P1
   RUTTER M, 1973, J CHILD PSYCHOL PSYC, V14, P241
   Schopler E., 1997, HDB AUTISM PERVASIVE, P767
   Shadish W, 2002, EXPT QUASIEXPERIMENT
   Shapiro R., 1987, J AM ACAD CHILD ADOL, V26, P485
   Sherer MR, 2005, J CONSULT CLIN PSYCH, V73, P525, DOI 10.1037/0022-006X.73.3.525
   Weiss MJ, 1999, BEHAV INTERVENT, V14, P3, DOI 10.1002/(SICI)1099-078X(199901/03)14:1<3::AID-BIN25>3.0.CO;2-F
NR 42
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0885-6257
EI 1469-591X
J9 EUR J SPEC NEEDS EDU
JI Eur. J. Spec. Needs Educ.
PY 2013
VL 28
IS 1
BP 64
EP 77
DI 10.1080/08856257.2012.743729
PG 14
WC Education, Special
SC Education & Educational Research
GA AR5AO
UT WOS:000343597700005
ER

PT J
AU Kemp, S
   Petriwskyj, A
   Shakespeare-Finch, J
   Thorpe, K
AF Kemp, Steven
   Petriwskyj, Anne
   Shakespeare-Finch, Jane
   Thorpe, Karen
TI What if you're really different? Case studies of children with high
   functioning Autism participating in the Get REAL programme who had
   atypical learning trajectories
SO EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
LA English
DT Article
DE co-morbidity; experiential learning; high functioning; autism; ASD;
   group social skills; behaviour
ID SOCIAL-SKILLS INTERVENTIONS; SPECTRUM DISORDERS; ASPERGER-SYNDROME;
   CONTROLLED-TRIAL; DIFFICULTIES-QUESTIONNAIRE; ANXIETY DISORDERS;
   THERAPY; ADOLESCENTS; STRENGTHS; SAMPLE
AB Evaluation of the Get REAL programme in an inclusive primary school setting has indicated its effectiveness in promoting pro-social behaviour for children with high functioning Autism. However, two children with co-morbid diagnoses and complex personal circumstances showed less consistent improvements. In order to explain their unique trajectories, not readily derived from quantitative studies, an exploratory case study approach was used to examine contextual influences on patterns of progress. Multiple data sources included coded video footage from the Get REAL programme, school reports on conduct, and parents and classroom teacher reports using the Strengths and Difficulties Questionnaire. While results provide support for the efficacy of the Get REAL programme for the two children, they also highlight the value of co-ordinated strategies and collaborative individualised approaches in more complex cases. This paper outlines the Get REAL intervention and a range of other school and support agency strategies impacting progress.
C1 [Kemp, Steven; Shakespeare-Finch, Jane; Thorpe, Karen] Queensland Univ Technol, Sch Psychol & Counselling, Fac Hlth, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia.
   [Petriwskyj, Anne] Queensland Univ Technol, Fac Educ, Sch Early Childhood, Brisbane, Qld 4001, Australia.
RP Shakespeare-Finch, J (reprint author), Queensland Univ Technol, Sch Psychol & Counselling, Fac Hlth, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia.
EM j.shakespeare-finch@qut.edu.au
CR Attwood T., 2000, AUTISM, V4, P85, DOI DOI 10.1177/1362361300004001006
   Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Forlin C., 2011, BRIT J SPECIAL ED, V38, P135, DOI [10.1111/j.1467-8578.2011.00517.x, DOI 10.1111/J.1467-8578.2011.00517.X]
   Gillott A, 2001, AUTISM, V5, P277, DOI 10.1177/1362361301005003005
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Gould E, 2011, BEHAV INTERVENT, V26, P50, DOI 10.1002/bin.320
   Guldberg A., 2011, EUROPEAN J SPECIAL N, V26, P65, DOI DOI 10.1080/08856257.2011.543534
   Hartley SL, 2009, AUTISM, V13, P485, DOI 10.1177/1362361309335717
   Horner RH, 2002, J AUTISM DEV DISORD, V32, P423, DOI 10.1023/A:1020593922901
   Kemp S., J AUTISM DEV DISORDE
   Koning C., 2010, THESIS U ALBERTA
   Kuusikko S, 2008, J AUTISM DEV DISORD, V38, P1697, DOI 10.1007/s10803-008-0555-9
   Lang R, 2010, DEV NEUROREHABIL, V13, P53, DOI 10.3109/17518420903236288
   LeGoff DB, 2004, J AUTISM DEV DISORD, V34, P557, DOI 10.1007/s10803-004-2550-0
   MacNeil B. M., 2008, AUTISM SPECTRUM DISO, V3, P1, DOI [10.1016/j.rasd.2008.06.001, DOI 10.1016/J.RASD.2008.06.001]
   Manti E, 2011, EUR J SPEC NEEDS EDU, V26, P411, DOI 10.1080/08856257.2011.597172
   Mellor D, 2005, AUST PSYCHOL, V40, P215, DOI 10.1080/00050060500243475
   Merriam S., 2002, QUALITATIVE RES PRAC
   Nijmeijer JS, 2008, CLIN PSYCHOL REV, V28, P692, DOI 10.1016/j.cpr.2007.10.003
   Owens G, 2008, J AUTISM DEV DISORD, V38, P1944, DOI 10.1007/s10803-008-0590-6
   Parsons S., 2011, EUROPEAN J SPECIAL N, V26, P47, DOI 10.1080/08856257.2011.543532
   Reaven JA, 2009, FOCUS AUTISM DEV DIS, V24, P27, DOI 10.1177/1088357608327666
   Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0
   Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
   Rotheram-Fuller E, 2011, PSYCHOL SCHOOLS, V48, P263, DOI 10.1002/pits.20552
   Russell E, 2005, AUST NZ J PSYCHIAT, V39, P633, DOI 10.1080/j.1440-1614.2005.01637.x
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Sze K. M., 2007, J CONTEMP PSYCHOTHER, V37, P133, DOI 10.1007/s10879-007-9048-y
   Thomeer M., 2006, FOCUS AUTISM OTHER D, V21, P237, DOI DOI 10.1177/10883576060210040501
   White SW, 2010, CLIN CHILD FAM PSYCH, V13, P77, DOI 10.1007/s10567-009-0062-3
   White SW, 2010, FOCUS AUTISM DEV DIS, V25, P209, DOI 10.1177/1088357610380595
   Williams White S., 2006, J AUTISM DEV DISORD, V37, P1858, DOI [10.1007/s10803-006-0320-x, DOI 10.1007/S10803-006-0320-X]
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
NR 35
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0885-6257
EI 1469-591X
J9 EUR J SPEC NEEDS EDU
JI Eur. J. Spec. Needs Educ.
PY 2013
VL 28
IS 1
BP 91
EP 108
DI 10.1080/08856257.2012.749609
PG 18
WC Education, Special
SC Education & Educational Research
GA AR5AO
UT WOS:000343597700007
ER

PT J
AU Linton, AC
   Germundsson, P
   Heimann, M
   Danermark, B
AF Linton, Ann-Charlotte
   Germundsson, Per
   Heimann, Mikael
   Danermark, Berth
TI Teachers' social representation of students with Asperger diagnosis
SO EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
LA English
DT Article
DE Asperger diagnosis; mainstream teachers; drop-out; social
   representations; inclusion
ID SPECIAL-EDUCATION; CHILDREN; GENDER; SPECTRUM; BEHAVIOR; AUTISM;
   EXPERIENCES; DISORDERS; VIEWS; ADHD
AB While progress has been made for including students with disability into mainstream schools, trends point to problems for students with Asperger syndrome (AS) diagnosis who have a propensity to dropping out of school. Teachers' perceptions and understanding of AS will affect expectations and the attainment of educational targets. Thus, to avoid barriers to students' learning and participation, there is a need to shed light on teachers' perceptions and beliefs that bear on teachers educational provision for students with AS. The aim of the study was therefore to elucidate mainstream teachers' representations of students with AS by using the theoretical framework of Social Representation Theory and particularly looking at the effects of the sex of the teacher, grade level being taught and when the teachers received training themselves. Teachers in mainstream schools in Sweden were invited to complete a web-based questionnaire (N = 170). Data were collected through an association task where the participants were asked to produce up to five words or phrases for the stimulus phrase 'student with Asperger diagnosis'. The data were analysed through categorisation. We found that two-thirds of the macro-categories of mentions relate to 'disabling aspects', 'individual needs' and 'individual characteristics', while a third of the elements were tied to the environment and educational provision. Our results suggest that a medical approach dominates especially earlier trained teachers; however, there is a tendency to view the school environment as increasingly important. Representations about the disabling aspects decreased with the increase in the grades being taught, whereas the educational aspects increase with the increase in grades. Male teachers are more prone to relate to environmental aspects and educational provision while female teachers more often relate to needs and disability. We conclude that teachers tend to view AS from a medical approach but that the school environment is seen as increasingly important.
C1 [Linton, Ann-Charlotte] Linkoping Univ, Swedish Inst Disabil Res, Linkoping, Sweden.
   [Germundsson, Per] Malmo Univ, Dept Hlth & Welf Studies, Malmo, Sweden.
   [Linton, Ann-Charlotte; Heimann, Mikael] Linkoping Univ, Dept Behav Sci & Learning, Linkoping, Sweden.
   [Danermark, Berth] Univ Orebro, Swedish Inst Disabil Res, SE-70182 Orebro, Sweden.
RP Linton, AC (reprint author), Linkoping Univ, Swedish Inst Disabil Res, Linkoping, Sweden.
EM ann-charlotte.linton@oru.se
CR Abikoff HB, 2002, J ABNORM CHILD PSYCH, V30, P349, DOI 10.1023/A:1015713807297
   Abric J.-C., 2003, METHODES ETUDE REPRE
   Abric J.-C., 2001, REPRESENTATIONS SOCI, P42
   Alves-Mazzotti A., 2011, ED PROFESSIONALIZATI, P136
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Avramidis E., 2002, EUROPEAN J SPECIAL N, V17, P129, DOI DOI 10.1080/08856250210129056
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Batten A., 2005, IMPROVING SCH, V8, P93, DOI DOI 10.1177/1365480205049341
   Brewin BJ, 2008, FOCUS AUTISM DEV DIS, V23, P242, DOI 10.1177/1088357608322997
   Chitiyo M., 2011, J RES SPECIAL ED NEE, V11, P70, DOI 10.1111/j.1471-3802.2010.01181.x
   Coles EK, 2012, J ATTEN DISORD, V16, P101, DOI 10.1177/1087054710381481
   Demetriou H, 2009, EDUC STUD, V35, P449, DOI 10.1080/03055690902876552
   Doise W., 1992, B PSYCHOL, V45, P405
   Dworzynski K, 2012, J AM ACAD CHILD PSY, V51, P788, DOI 10.1016/j.jaac.2012.05.018
   Englund U., EUROPEAN J SOCIAL WO
   Eriksson A., 2009, THESIS GOTHENBURG U
   Farrell P., 2009, EUROPEAN J SPECIAL N, V24, P407
   Frederickson A., 2010, J RES SPECIAL ED NEE, V10, P63
   Germundsson P., 2011, LARARE SOCIALSEKRETE
   Haase M, 2008, BRIT J SOCIOL EDUC, V29, P597, DOI 10.1080/01425690802423270
   Harvey A., 2000, INCLUSION AUTISM IS
   Hattie J, 2012, VISIBLE LEARNING TEA
   Howarth C, 2006, BRIT J SOC PSYCHOL, V45, P65, DOI 10.1348/014466605X43777
   Humphrey N, 2008, AUTISM, V12, P23, DOI 10.1177/1362361307085267
   Humphrey N., 2008, J RES SPECIAL ED NEE, V8, P132
   Huws JC, 2011, BRIT J LEARN DISABIL, V39, P98, DOI 10.1111/j.1468-3156.2010.00624.x
   Isaksson J., 2007, EUROPEAN J SPECIAL N, V22, P75, DOI 10.1080/08856250601082323
   Jerlinder K, 2010, EUROPEAN J SPECIAL N, V25, P45, DOI 10.1080/08856250903450830
   JONES MG, 1990, J RES SCI TEACH, V27, P861, DOI 10.1002/tea.3660270906
   Jordan R, 2005, Pediatr Rehabil, V8, P104
   JOVCHELOVITCH S., 2007, KNOWLEDGE CONTEXT RE
   Martino WJ, 2008, CURRICULUM INQ, V38, P189, DOI 10.1111/j.1467-873X.2007.00405.x
   MCINTYRE LL, 1990, J EDUC RES, V83, P166
   Moliner P., 2002, REPRESENTATIONS SOCI
   Moores-Abdool W., 2010, ISSUES TEACHER ED, V19, P153
   Moscovici S, 2000, SOCIAL REPRESENTATIO
   Myles BS, 2003, CHILD ADOL PSYCH CL, V12, P123, DOI 10.1016/S1056-4993(02)00048-2
   Parsons S, 2010, INT J INCLUSIVE EDUC, V14, P67, DOI 10.1080/13603110802504135
   Parsons S., 2011, EUROPEAN J SPECIAL N, V26, P47, DOI 10.1080/08856257.2011.543532
   Pisula E, 2012, SCHOOL PSYCHOL INT, V33, P185, DOI 10.1177/0143034311415784
   Ratinaud P., 2012, LANGAGES, V3, P93
   RITTER DR, 1989, EXCEPT CHILDREN, V55, P559
   Sciutto M, 2012, FOCUS AUTISM DEV DIS, V27, P177, DOI 10.1177/1088357612450511
   Smith W. G., 2008, ED501717
   SOU, 1999, 199963 SOU MIN ED
   Sousa C. P., 2011, ED PROFESSIONALIZATI, P68
   Swedish National Agency for Education, 2009, SKOL ASP SYNDR ERF F
   Swedish National Agency for Education, 2008, RATT TILL UTB EL SOM
   Tapper K, 2000, AGGRESSIVE BEHAV, V26, P442, DOI 10.1002/1098-2337(200011)26:6<442::AID-AB3>3.0.CO;2-C
   Thomas G., 2007, DECONSTRUCTING SPECI
   Tideman M., 2004, STORA UTMANINGEN ATT
   UNESCO, 1994, AD WORLD C SPEC NEED
   Vialle W., 2000, HDB CHILD DEV
   Wagner W., 1999, ASIAN J SOC PSYCHOL, V2, P95, DOI [10.1111/1467-839X.00028, DOI 10.1111/1467-839X.00028]
   Wehmeyer M. L., 2006, SAGE HDB GENDER ED, P392
   Whannell R., 2011, AUSTR J TEACHER ED, V36, P22
   WING L, 1981, PSYCHOL MED, V11, P115
NR 57
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0885-6257
EI 1469-591X
J9 EUR J SPEC NEEDS EDU
JI Eur. J. Spec. Needs Educ.
PY 2013
VL 28
IS 4
BP 392
EP 412
DI 10.1080/08856257.2013.812404
PG 21
WC Education, Special
SC Education & Educational Research
GA AR5BH
UT WOS:000343599600002
ER

PT J
AU Seale, J
AF Seale, Jane
TI Touching the future of technology for autism: lessons from the HANDS
   project
SO EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
LA English
DT Book Review
C1 [Seale, Jane] Univ Exeter, Grad Sch Educ, Exeter, Devon, England.
RP Seale, J (reprint author), Univ Exeter, Grad Sch Educ, Exeter, Devon, England.
EM j.seale@exeter.ac.uk
CR Mintz J, 2012, AMB INTELL SMART ENV, V15, P1
NR 1
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0885-6257
EI 1469-591X
J9 EUR J SPEC NEEDS EDU
JI Eur. J. Spec. Needs Educ.
PY 2013
VL 28
IS 4
BP 525
EP 528
DI 10.1080/08856257.2013.844557
PG 6
WC Education, Special
SC Education & Educational Research
GA AR5BH
UT WOS:000343599600012
ER

PT J
AU Fallon, C
   Edwards, C
AF Fallon, Catherine
   Edwards, Carl
TI The confidence factor: a practical resource for use with pupils with
   special educational needs including autism spectrum disorders aged 11-16
SO SEX EDUCATION-SEXUALITY SOCIETY AND LEARNING
LA English
DT Book Review
C1 [Fallon, Catherine] Canterbury Christ Church Univ, Canterbury, Kent, England.
   [Edwards, Carl] Riverside Special Sch, Orpington, England.
RP Fallon, C (reprint author), Canterbury Christ Church Univ, Canterbury, Kent, England.
EM Catherine.Fallon@canterbury.ac.uk; Carl.Edwards@riverside.bromley.sch.uk
CR DUIGAN S, 2010, CONFIDENCE FACTOR PR
NR 1
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1468-1811
EI 1472-0825
J9 SEX EDUC-SEX SOC LEA
JI Sex Educ.-Sex. Soc. Learn.
PY 2013
VL 13
IS 1
BP 117
EP 118
DI 10.1080/14681811.2011.649990
PG 2
WC Education & Educational Research; Public, Environmental & Occupational
   Health
SC Education & Educational Research; Public, Environmental & Occupational
   Health
GA AR6QQ
UT WOS:000343708400010
ER

PT J
AU de Villiers, J
   Myers, B
   Stainton, RJ
AF de Villiers, Jessica
   Myers, Brooke
   Stainton, Robert J.
TI Revisiting pragmatic abilities in autism spectrum disorders A follow-up
   study with controls
SO PRAGMATICS & COGNITION
LA English
DT Article
DE autism spectrum disorder; pragmatics; pragmatic determinants of literal
   content
ID HIGH-FUNCTIONING AUTISM; PERVASIVE DEVELOPMENTAL DISORDERS;
   ASPERGER-SYNDROME; LANGUAGE; CHILDREN; DISCOURSE; ADULTS; COMMUNICATION;
   INDIVIDUALS; BEHAVIOR
AB In a 2007 paper, we argued that speakers with Autism Spectrum Disorders (ASDs) exhibit pragmatic abilities which are surprising given the usual understanding of communication in that group. That is, it is commonly reported that people diagnosed with an ASD have trouble with metaphor, irony, conversational implicature and other non-literal language. This is not a matter of trouble with knowledge and application of rules of grammar. The difficulties lie, rather, in successful communicative interaction. Though we did find pragmatic errors within literal talk, the transcribed conversations we studied showed many, many successes. A second paper reinforced our finding of a general level of success (de Villiers, Myers, and Stainton 2012). It considered differences within the class of pragmatically-inflected yet literal speech acts. The present paper carries our project forward. It overcomes some of the methodological limitations of the second paper, by increasing sample size, and looking at frequency of use rather than just seeming errors. It also includes a control sample. The emerging results are two-fold. On the one hand, there was a slight, statistically significant difference in frequency of use between our participants and the controls in four subcategories: indexicals, possessives, polysemy and degree on a scale. In all four, the participants diagnosed with ASDs had fewer occurrences overall, relative to controls. On the other hand, there was no significant difference in error rates between ASDs and controls - not in any of the eight categories of pragmatic determinants of literal content that we coded for. The upshot is that, though there were less-preferred forms for participants with ASDs, they do very well indeed with pragmatic determinants of literal content.
C1 [de Villiers, Jessica] Univ British Columbia, Dept English, Vancouver, BC V6T 1Z1, Canada.
   [Myers, Brooke] Univ British Columbia, Dept Educ & Counselling Psychol, Vancouver, BC V6T 1Z4, Canada.
   [Stainton, Robert J.] Univ Western Ontario, Dept Philosophy, London, ON N6A 5B8, Canada.
RP de Villiers, J (reprint author), Univ British Columbia, Dept English, 397-1873 East Mall, Vancouver, BC V6T 1Z1, Canada.
EM Jessicadevilliers@mail.ubc.ca; brookemyers@gmail.com; rstainto@uwo.ca
CR Adams C, 2002, J CHILD PSYCHOL PSYC, V43, P679, DOI 10.1111/1469-7610.00056
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Asp E., 2010, LANGUAGE BREAKS ANAL, DOI [10.1017/CBO9780511845352, DOI 10.1017/CBO9780511845352]
   Asp E., 2013, TWIN PARADO IN PRESS
   Bailey A, 1996, J CHILD PSYCHOL PSYC, V37, P89, DOI 10.1111/j.1469-7610.1996.tb01381.x
   Baltaxe CA, 1977, J PEDIATR PSYCHOL, V2, P176, DOI DOI 10.1093/JPEPSY/2.4.176
   BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
   Capps L., 1998, AUTISM, V2, P325, DOI DOI 10.1177/1362361398024002
   Carston R., 2002, THOUGHTS UTTERANCES, DOI [10.1002/9780470754603, DOI 10.1002/9780470754603]
   Colle L, 2008, J AUTISM DEV DISORD, V38, P28, DOI 10.1007/s10803-007-0357-5
   de Villiers J., 2007, MIDWEST STUD PHILOS, V31, P292, DOI DOI 10.1111/J.1475-4975.2007.00151.X
   De Villiers J, 2012, PRAGMATICS CONTEXT
   Dennis M, 2001, J AUTISM DEV DISORD, V31, P47, DOI 10.1023/A:1005661613288
   de Villiers J, 2007, J AUTISM DEV DISORD, V37, P1375, DOI 10.1007/s10803-006-0264-1
   Diehl JJ, 2009, APPL PSYCHOLINGUIST, V30, P385, DOI 10.1017/S0142716409090201
   Ezcurdia M., 2013, SEMANTICS PRAGMATICS
   FINE J, 1991, J CHILD PSYCHOL PSYC, V32, P771, DOI 10.1111/j.1469-7610.1991.tb01901.x
   FINE J, 1994, J AUTISM DEV DISORD, V24, P315, DOI 10.1007/BF02172230
   FRITH U, 1989, BRIT J DISORD COMMUN, V24, P123
   Ghaziuddin M, 1996, J AUTISM DEV DISORD, V26, P585, DOI 10.1007/BF02172348
   Gold R, 2010, BRAIN LANG, V113, P124, DOI [10.1016/j.bandl.2010.03.002, 10.1016/j.band1.2010.03.002]
   Grice H. P., 1975, SYNTAX SEMANTICS, P41, DOI DOI 10.1017/S0022226700005296
   HAPPE FGE, 1995, METAPHOR SYMB ACT, V10, P275, DOI 10.1207/s15327868ms1004_3
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kanner L, 1943, NERV CHILD, V2, P217
   Kelley E, 2006, J AUTISM DEV DISORD, V36, P807, DOI 10.1007/s10803-006-0111-4
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Mackay G., 2004, CHILD LANG TEACH THE, V20, P13, DOI 10.1191/0265659004ct261oa
   Martin I, 2004, J AUTISM DEV DISORD, V34, P311, DOI 10.1023/B:JADD.0000029553.52889.15
   Paul R, 2009, J AUTISM DEV DISORD, V39, P115, DOI 10.1007/s10803-008-0607-1
   Pijnacker J, 2009, J AUTISM DEV DISORD, V39, P607, DOI 10.1007/s10803-008-0661-8
   PRIZANT BM, 1981, J SPEECH HEAR DISORD, V46, P241
   Pulvermuller F, 2009, BRAIN LANG, V110, P81, DOI 10.1016/j.bandl.2008.12.001
   Pustejovsky James, 1995, GENERATIVE LEXICON
   Rajendran G, 2005, J AUTISM DEV DISORD, V35, P429, DOI 10.1007/s10803-005-5033-z
   Recanati Francois, 2004, LITERAL MEANING
   Russell J., 1997, AUTISM EXECUTIVE DIS, P256
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rydell Patrick J., 1994, Journal of Autism and Developmental Disorders, V24, P719, DOI 10.1007/BF02172282
   Scharfstein LA, 2011, J ABNORM CHILD PSYCH, V39, P865, DOI 10.1007/s10802-011-9498-2
   Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087)
   Sperber D, 1986, RELEVANCE
   SZATMARI P, 1989, J AUTISM DEV DISORD, V19, P213, DOI 10.1007/BF02211842
   TAGERFLUSBERG H, 1991, J CHILD PSYCHOL PSYC, V32, P1123, DOI 10.1111/j.1469-7610.1991.tb00353.x
   Tager-Flusberg H, 2001, INT REV RES MENT RET, V23, P185
   Tager-Flusberg H., 1993, UNDERSTANDING OTHER, P138
   Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
   VOLDEN J, 1991, J AUTISM DEV DISORD, V21, P109, DOI 10.1007/BF02284755
NR 48
TC 0
Z9 0
PU JOHN BENJAMINS PUBLISHING COMPANY
PI AMSTERDAM
PA PO BOX 36224, 1020 ME AMSTERDAM, NETHERLANDS
SN 0929-0907
EI 1569-9943
J9 PRAGMAT COGN
JI Pragmat. Cogn.
PY 2013
VL 21
IS 2
BP 253
EP 269
DI 10.1075/pc.21.2.01vil
PG 17
WC Linguistics; Language & Linguistics
SC Linguistics
GA AN7XJ
UT WOS:000340814000001
ER

PT S
AU Epley, N
   Schroeder, J
   Waytz, A
AF Epley, Nicholas
   Schroeder, Juliana
   Waytz, Adam
BE Gervais, SJ
TI Motivated Mind Perception: Treating Pets as People and People as Animals
SO OBJECTIFICATION AND (DE)HUMANIZATION
SE Nebraska Symposium on Motivation
LA English
DT Article; Proceedings Paper
CT 60th Nebraska Symposium on Motivation
CY 2012
CL Lincoln, NE
ID AUTISM SPECTRUM DISORDER; SOCIAL COGNITION; SECONDARY EMOTIONS; EMPATHIC
   ACCURACY; ANTHROPOMORPHISM; ATTRIBUTION; DEHUMANIZATION; CONSEQUENCES;
   KNOWLEDGE; FACE
AB Human beings have a sophisticated ability to reason about the minds of others, often referred to as using one's theory of mind or mentalizing. Just like any other cognitive ability, people engage in reasoning about other minds when it seems useful for achieving particular goals, but this ability remains disengaged otherwise. We suggest that understanding the factors that engage our ability to reason about the minds of others helps to explain anthropomorphism: cases in which people attribute minds to a wide range of nonhuman agents, including animals, mechanical and technological objects, and supernatural entities such as God. We suggest that engagement is guided by two basic motivations: (1) the motivation to explain and predict others' actions, and (2) the motivation to connect socially with others. When present, these motivational forces can lead people to attribute minds to almost any agent. When absent, the likelihood of attributing a mind to others, even other human beings, decreases. We suggest that understanding the factors that engage our theory of mind can help to explain the inverse process of dehumanization, and also why people might be indifferent to other people even when connecting to them would improve their momentary wellbeing.
C1 [Epley, Nicholas; Schroeder, Juliana] Univ Chicago, Chicago, IL 60637 USA.
EM epley@chicagobooth.edu
CR Abraham A., 2012, EFFECT MOBILE UNPUB
   Apperly IA, 2006, PSYCHOL SCI, V17, P841, DOI 10.1111/j.1467-9280.2006.01791.x
   Atran S, 2004, BEHAV BRAIN SCI, V27, P713
   Avery M. E., 1993, PAIN NEONATES
   Aydin N, 2012, J EXP SOC PSYCHOL, V48, P446, DOI 10.1016/j.jesp.2011.09.011
   Aydin N, 2010, PERS SOC PSYCHOL B, V36, P742, DOI 10.1177/0146167210367491
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Barr D. J., 2004, FIGURATIVE LANGUAGE
   Bastian B, 2010, J EXP SOC PSYCHOL, V46, P107, DOI 10.1016/j.jesp.2009.06.022
   Baumeister RF, 2011, ANNU REV PSYCHOL, V62, P331, DOI 10.1146/annurev.psych.093008.131126
   Bering JM, 2006, BEHAV BRAIN SCI, V29, P486
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Chamberlain B, 2007, J AUTISM DEV DISORD, V37, P230, DOI 10.1007/s10803-006-0164-4
   Chevallier C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031107
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   Chomsky Noam, 1957, SYNTACTIC STRUCTURES
   Cunningham WA, 2012, CURR DIR PSYCHOL SCI, V21, P54, DOI 10.1177/0963721411430832
   Dando-Collins Stephen, 2004, STANDING BEAR IS PER
   DECASPER AJ, 1980, SCIENCE, V208, P1174, DOI 10.1126/science.7375928
   Demoulin S, 2004, COGNITION EMOTION, V18, P71, DOI 10.1080/02699930244000444
   Dennett D, 1987, INTENTIONAL STANCE
   Diener E., 2002, PSYCHOL SCI, V13, P80
   Epley N., 2008, SOCIAL PERSONALITY P, V2, P1455, DOI DOI 10.1111/J.1751-9004.2008.00115.X
   Epley N, 2007, PSYCHOL REV, V114, P864, DOI 10.1037/0033-295X.114.4.864
   Epley N, 2008, PSYCHOL SCI, V19, P114, DOI 10.1111/j.1467-9280.2008.02056.x
   Epley N, 2008, SOC COGNITION, V26, P143, DOI 10.1521/soco.2008.26.2.143
   Epley Nicholas, 2010, HDB SOCIAL PSYCHOL, P498
   Farah MJ, 2007, AM J BIOETHICS, V7, P37, DOI 10.1080/15265160601064199
   Feith D., 2011, WALL STREET J
   FISKE ST, 1993, AM PSYCHOL, V48, P621, DOI 10.1037/0003-066X.48.6.621
   Fleeson W, 2002, J PERS SOC PSYCHOL, V83, P1409, DOI 10.1037//0022-3514.83.6.1409
   Gaunt R, 2002, J EXP SOC PSYCHOL, V38, P508, DOI 10.1016/S0022-1031(02)00014-8
   Gebauer JE, 2012, J PERS, V80, P465, DOI 10.1111/j.1467-6494.2011.00730.x
   Gilovich T., 1999, SOCIAL PSYCHOL EMOTI, P69, DOI 10.1037/10320-003
   Goff PA, 2008, J PERS SOC PSYCHOL, V94, P292, DOI 10.1037/0022-3514.94.2.292
   Gray HM, 2007, SCIENCE, V315, P619, DOI 10.1126/science.1134475
   Gray K, 2010, PERS SOC PSYCHOL REV, V14, P7, DOI 10.1177/1088868309350299
   Gruenfeld DH, 2008, J PERS SOC PSYCHOL, V95, P111, DOI 10.1037/0022-3514.95.1.111
   Guthrie Stewart Eliott, 1993, FACES CLOUDS
   Hall JA, 2008, PERS SOC PSYCHOL B, V34, P144, DOI 10.1177/0146167207309192
   Haque OS, 2012, PERSPECT PSYCHOL SCI, V7, P176, DOI 10.1177/1745691611429706
   Harris LT, 2006, PSYCHOL SCI, V17, P847, DOI 10.1111/j.1467-9280.2006.01793.x
   Harrison M. A., 2010, J SOCIAL EVOLUTIONAR, V4, P34
   Haslam N, 2013, NEBR SYM MOTIV, V60, P25, DOI 10.1007/978-1-4614-6959-9_2
   HEBB DO, 1946, PSYCHOL REV, V53, P88, DOI 10.1037/h0063033
   Heberlein AS, 2004, P NATL ACAD SCI USA, V101, P7487, DOI 10.1073/pnas.0308220101
   Heider F., 1958, PSYCHOL INTERPERSONA
   Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
   Herrmann E, 2007, SCIENCE, V317, P1360, DOI 10.1126/science.1146282
   Hill J. B., 2000, LEGACY LUNA STORY TR
   Horowitz Alexandra C, 2009, INSIDE DOG WHAT DOGS
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Hume David, 1957, NATURAL HIST RELIG
   Humphrey N., 2002, MIND MADE FLESH, P235
   Humphrey N.K., 1976, GROWING POINTS ETHOL
   Ickes W., 1997, EMPATHIC ACCURACY, P117
   Ickes W., 2003, EVERYDAY MIND READIN
   Ickes W, 2000, PERS RELATIONSHIP, V7, P95, DOI 10.1111/j.1475-6811.2000.tb00006.x
   Izuma K, 2011, P NATL ACAD SCI USA, V108, P17302, DOI 10.1073/pnas.1107038108
   Johnson SC, 2003, PHILOS T R SOC B, V358, P549, DOI 10.1098/rstb.2002.1237
   Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
   Kelley H. H., 1967, NEBRASKA S MOTIVATIO, V15, P192
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Kozak MN, 2006, J PERS SOC PSYCHOL, V90, P543, DOI 10.1037/0022-3514.90.4.543
   Kraus MW, 2010, PSYCHOL SCI, V21, P1716, DOI 10.1177/0956797610387613
   Krienen FM, 2010, J NEUROSCI, V30, P13906, DOI 10.1523/JNEUROSCI.2180-10.2010
   Lakoff G., 1980, METAPHORS WE LIVE BY
   Lesher J. H., 1992, XENOPHANES COLOPHON
   Leyens JP, 2000, PERS SOC PSYCHOL REV, V4, P186, DOI 10.1207/S15327957PSPR0402_06
   Locke J, 1997, ESSAY HUMAN UNDERSTA
   Luczak H, 2003, ERGONOMICS, V46, P1361, DOI 10.1080/00140130310001610883
   Martin A, 2003, COGN NEUROPSYCHOL, V20, P575, DOI 10.1080/02643290342000005
   McConnell AR, 2011, J PERS SOC PSYCHOL, V101, P1239, DOI 10.1037/a0024506
   Medin DL, 2004, PSYCHOL REV, V111, P960, DOI 10.1037/0033-295x.111.4.960
   MELTZOFF AN, 1977, SCIENCE, V198, P75, DOI 10.1126/science.198.4312.75
   Morewedge C. K., 2006, THESIS HARVARD U
   Morewedge CK, 2007, J PERS SOC PSYCHOL, V93, P1, DOI 10.1037/0022-3514.93.1.1
   Nickerson RS, 1999, PSYCHOL BULL, V125, P737, DOI 10.1037//0033-2909.125.6.737
   Norenzayan A, 2008, SCIENCE, V322, P58, DOI 10.1126/science.1158757
   Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
   Piaget J., 1929, CHILDS CONCEPTION WO
   Riby DM, 2008, NEUROPSYCHOLOGIA, V46, P2855, DOI 10.1016/j.neuropsychologia.2008.05.003
   Schroeder J., 2012, MISTAKENLY SEE UNPUB
   Serpell JA, 2003, SOC ANIM, V11, P83, DOI 10.1163/156853003321618864
   Shaw G., 1901, 3 PLAYS PURITANS
   Sherman G. D., 2012, CUTENESS CUES UNPUB
   Sherman GD, 2011, EMOT REV, V3, P245, DOI 10.1177/1754073911402396
   SHERROD LR, 1979, INFANT BEHAV DEV, V2, P279, DOI 10.1016/S0163-6383(79)80037-5
   Singer P. W., 2009, WIRED WAR ROBOTICS R
   Spitzer G., 2011, CLEVER APES EPISODE
   Sproull L, 1996, HUM-COMPUT INTERACT, V11, P97, DOI 10.1207/s15327051hci1102_1
   Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129
   Van Kleef G. A., 2009, PSYCHOL SCI, V19, P1315
   Wantanabe S., 2007, APPL ANIMAL BEHAV SC, V106, P193
   Waytz A, 2012, J EXP SOC PSYCHOL, V48, P70, DOI 10.1016/j.jesp.2011.07.012
   Waytz A., 2012, LONELINESS ANT UNPUB
   Waytz A, 2010, J PERS SOC PSYCHOL, V99, P410, DOI 10.1037/a0020240
   Waytz A, 2010, TRENDS COGN SCI, V14, P383, DOI 10.1016/j.tics.2010.05.006
   Waytz A, 2010, CURR DIR PSYCHOL SCI, V19, P58, DOI 10.1177/0963721409359302
   Waytz A, 2010, PERSPECT PSYCHOL SCI, V5, P219, DOI 10.1177/1745691610369336
   WHITE RW, 1959, PSYCHOL REV, V66, P297, DOI 10.1037/h0040934
   Xu XJ, 2009, J NEUROSCI, V29, P8525, DOI 10.1523/JNEUROSCI.2418-09.2009
NR 103
TC 5
Z9 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 0146-7875
BN 978-1-4614-6959-9; 978-1-4614-6958-2
J9 NEBR SYM MOTIV
JI Nebr. Symp. Motiv.
PY 2013
VL 60
BP 127
EP 152
DI 10.1007/978-1-4614-6959-9_6
PG 26
WC Psychology, Social
SC Psychology
GA BB0JZ
UT WOS:000340271100006
PM 23947281
ER

PT J
AU Charlot, L
   Beasley, JB
AF Charlot, Lauren
   Beasley, Joan B.
TI Intellectual Disabilities and Mental Health: United States-Based
   Research
SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE intellectual disabilities; autism spectrum disorder; applied behavior
   analysis; psychiatric disorders; psychopharmacological treatment; mental
   health
ID ABERRANT-BEHAVIOR-CHECKLIST; PSYCHOTROPIC MEDICATION USE; AUTISM
   SPECTRUM DISORDER; DEVELOPMENTAL-DISABILITIES; CHALLENGING BEHAVIORS;
   PSYCHIATRIC-DISORDERS; PEDIATRIC PSYCHOPHARMACOLOGY; DEPRESSIVE
   EQUIVALENTS; AGGRESSIVE BEHAVIORS; CLINICAL-PRACTICE
AB In the United States, research directed specifically at improving our understanding of the psychiatric assessment and treatment of individuals with intellectual disabilities ( ID) has grown, yet lags far behind efforts for typically developing children and adults. In the United States, a lack of a national approach to the mental health problems of people with ID has likely contributed to a lack of a clear and cohesive national research agenda for "dual diagnosis" of intellectual disabilities and mental health disorders. Despite these concerns, much has been learned and important progress has been made. This article provides an overview of the latest developments in research and social policy on behalf of persons with ID and mental health needs in the United States.
C1 [Charlot, Lauren] Univ Massachusetts, Sch Med, Dept Psychiat, Worcester, MA 01655 USA.
   [Beasley, Joan B.] Univ New Hampshire, Inst Disabil, Durham, NH 03824 USA.
RP Charlot, L (reprint author), Univ Massachusetts, Sch Med, Dept Psychiat, Worcester, MA 01655 USA.
EM CharlotL@ummhc.org
CR Achenbach T M, 2000, Pediatr Rev, V21, P265, DOI 10.1542/pir.21-8-265
   AMAN MG, 1985, AM J MENT DEF, V89, P485
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Beasley J. B., 2002, CONT DEV DISABILITIE, P35
   Braddock DL, 2011, STATE STATES DEV DIS
   Cain NN, 2003, J INTELL DISABIL RES, V47, P31, DOI 10.1046/j.1365-2788.2003.00458.x
   Cassidy SB, 2009, EUR J HUM GENET, V17, P3, DOI 10.1038/ejhg.2008.165
   Charlot L, 2008, J MENT HEALTH RES IN, V1, P238, DOI 10.1080/19315860802313947
   Charlot L, 2011, J INTELL DISABIL RES, V55, P199, DOI 10.1111/j.1365-2788.2010.01294.x
   Charlot L, 2007, J INTELL DISABIL RES, V51, P821, DOI 10.1111/j.1365-2788.2007.00972.x
   Charlot L. R., 2005, MOOD DISORDERS PEOPL, P17
   Charlot L. R., 2007, DIAGNOSTIC MANUAL IN, P271
   CHARLOT LR, 1993, AM J MENT RETARD, V98, P408
   Cordeiro L, 2011, J NEURODEV DISORD, V3, P57, DOI 10.1007/s11689-010-9067-y
   CRADDOCK N, 1994, J INTELL DISABIL RES, V38, P613
   Davis E, 2008, PSYCHIAT QUART, V79, P249, DOI 10.1007/s11126-008-9081-3
   Deutsch CK, 2008, DEV DISABIL RES REV, V14, P285, DOI 10.1002/ddrr.42
   Dossetor D., 2009, CURRENT PSYCHIAT REP, V11, P190
   Dykens EM, 2007, MENT RETARD DEV D R, V13, P272, DOI 10.1002/mrdd.20159
   EDELBROCK C, 1986, J CHILD PSYCHOL PSYC, V27, P181, DOI 10.1111/j.1469-7610.1986.tb02329.x
   Esbensen AJ, 2006, J INTELL DISABIL RES, V50, P248, DOI 10.1111/j.1365-2788.2005.00816.x
   Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P1339, DOI 10.1007/s10803-009-0750-3
   Esbensen AJ, 2003, J AUTISM DEV DISORD, V33, P617, DOI 10.1023/B:JADD.0000005999.27178.55
   Esbensen AJ, 2005, J INTELL DISABIL RES, V49, P481, DOI 10.1111/j.1365-2788.2005.00710.x
   Fletcher R., 2007, DIAGNOSTIC MANUAL IN
   Gardner W. I., 2012, HDB HIGH RISK CHALLE, P83
   Glahn DC, 2007, HUM BRAIN MAPP, V28, P488, DOI 10.1002/hbm.20401
   Hagerman R., 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-12
   Hagopian LP, 2008, J DEV PHYS DISABIL, V20, P467, DOI 10.1007/s10882-008-9114-8
   Harris J., 1998, DEV NEUROPSYCHIATRY, V2
   Hartley S. L., 2009, J MENTAL HLTH RES IN, V2, P11
   Hartley SL, 2009, AJIDD-AM J INTELLECT, V114, P147, DOI 10.1352/1944-7588-114.3.147
   Hess J, 2010, J MENT HEALTH RES IN, V3, P85, DOI 10.1080/19315861003690588
   Heyvaert M, 2010, J INTELL DISABIL RES, V54, P634, DOI 10.1111/j.1365-2788.2010.01291.x
   Hinton J., 2010, NADD B, V3, P58
   Hodapp RM, 2005, MENT RETARD DEV D R, V11, P340, DOI 10.1002/mrdd.20087
   Hunter R. H., 2008, PSYCHOL SERV, V5, P11, DOI 10.1037/1541-1559.5.1.11
   Hurley A. D., 2007, J INTELL DISABIL RES, V52, P905
   Jolin E. M., 2011, J AFFECT DISORDERS, V136, P222
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Kim S., 1999, POLICY RES BRIEF U M, V10, P1
   Kurtz PF, 2011, RES DEV DISABIL, V32, P2935, DOI 10.1016/j.ridd.2011.05.009
   LAINHART JE, 1994, J AUTISM DEV DISORD, V24, P587, DOI 10.1007/BF02172140
   Lakin C. K., 2007, MENTAL HLTH ASPECTS, V10, P78
   Lehrer D., 2009, MENT HLTH ASPECTS DE, V12, P23
   Levy SE, 2010, J DEV BEHAV PEDIATR, V31, P267, DOI 10.1097/DBP.0b013e3181d5d03b
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C, 2010, SOCIAL POLICY REPORT, V24, P1
   Lott IT, 2004, J INTELL DISABIL RES, V48, P563, DOI 10.1111/j.1365-2788.2004.00625.x
   LoVullo SV, 2009, RES DEV DISABIL, V30, P1288, DOI 10.1016/j.ridd.2009.05.004
   Lowry MA, 1998, J DEV PHYS DISABIL, V10, P387, DOI 10.1023/A:1021858622501
   Lubetsky M., 2011, J AUTISM DEV DISORD, V42, P1863
   Mandell D. S., 2008, PEDIATRICS, V121, P441
   Matson JL, 2010, RES DEV DISABIL, V31, P1570, DOI 10.1016/j.ridd.2010.05.005
   Matson J. L., 1998, DIAGNOSTIC ASSESSMEN
   Matson JL, 2009, RES DEV DISABIL, V30, P572, DOI 10.1016/j.ridd.2008.08.007
   Matson JL, 2011, CNS DRUGS, V25, P597, DOI 10.2165/11591700-000000000-00000
   MATSON JL, 1991, BRIT J PSYCHIAT, V159, P404, DOI 10.1192/bjp.159.3.404
   Matson JL, 2007, J INTELL DISABIL RES, V51, P25, DOI 10.1111/j.1365-2788.2006.00897.x
   Matson JL, 1998, RES DEV DISABIL, V19, P501, DOI 10.1016/S0891-4222(98)00021-3
   Matson JL, 2009, RES DEV DISABIL, V30, P603, DOI 10.1016/j.ridd.2008.10.001
   Matson JL, 2011, CURR OPIN PSYCHIATR, V24, P367, DOI 10.1097/YCO.0b013e3283422424
   Matson JL, 2012, RES DEV DISABIL, V33, P549, DOI 10.1016/j.ridd.2011.10.023
   McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142
   McDougle CJ, 2000, CHILD ADOL PSYCH CL, V9, P201
   McPheeters M. L., 2011, PEDIATRICS, V127, P1312
   Mitchell KJ, 2011, CURR OPIN NEUROBIOL, V21, P197, DOI 10.1016/j.conb.2010.08.009
   MOSS S, 1993, BRIT J PSYCHIAT, V163, P471, DOI 10.1192/bjp.163.4.471
   Munir K. M., 2009, PSYCHIATRY, V8, P448, DOI 10.1016/j.mppsy.2009.08.003
   Murphy NA, 2011, PEDIATRICS, V128, P795, DOI 10.1542/peds.2011-1467
   Myrbakk E, 2008, AM J MENT RETARD, V113, P54, DOI 10.1352/0895-8017(2008)113[54:SIWIDF]2.0.CO;2
   Neidert PL, 2010, PSYCHOL SERV, V7, P103, DOI 10.1037/a0018791
   Posey DJ, 2008, J CLIN INVEST, V118, P6, DOI 10.1172/JCI32483
   REISS S, 1994, J CONSULT CLIN PSYCH, V62, P28, DOI 10.1037//0022-006X.62.1.28
   REISS S, 1993, J INTELL DISABIL RES, V37, P287
   Research Units on Pediatric Psychopharmacology Autism Network, 2005, AM J PSYCHIAT, V62, P1361
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   ROBINS LN, 1982, PSYCHOL MED, V12, P855
   Rojahn J, 2011, RES DEV DISABIL, V32, P2309, DOI 10.1016/j.ridd.2011.07.035
   Rosenberg R. R., 2011, AUTISM RES TREAT, V2011, DOI DOI 10.1155/2011/874619
   Rowles BM, 2010, DEV DISABIL RES REV, V16, P273, DOI 10.1002/ddrr.120
   Royal College of Psychiatrists, 2001, DC LD DIAGN CRIT PSY
   Rubin I. L., 2007, MENTAL HLTH ASPECTS, V10, P1
   Ruedrich S, 2007, ACAD PSYCHIATR, V31, P430, DOI 10.1176/appi.ap.31.6.430
   Rutter M, 2011, J CHILD PSYCHOL PSYC, V52, P647, DOI 10.1111/j.1469-7610.2011.02367.x
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Shprintzen RJ, 2008, DEV DISABIL RES REV, V14, P3, DOI 10.1002/ddrr.2
   Singh NN, 2006, J EMOT BEHAV DISORD, V14, P169, DOI 10.1177/10634266060140030401
   Singh NN, 2009, J APPL RES INTELLECT, V22, P194, DOI 10.1111/j.1468-3148.2008.00488.x
   Singh NN, 2003, RES DEV DISABIL, V24, P158, DOI 10.1016/S0891-4222(03)00026-X
   Sohanpal SK, 2007, J INTELL DISABIL RES, V51, P750, DOI 10.1111/j.1365-2788.2006.00935.x
   Sturmey P, 2010, RES DEV DISABIL, V31, P1002, DOI 10.1016/j.ridd.2010.04.018
   Sturmey P, 2004, CLIN PSYCHOL PSYCHOT, V11, P222, DOI 10.1002/cpp.409
   Sturmey P., 2010, EUROPEAN PSYCHIAT RE, V3, P39
   Sullivan WF, 2011, CAN FAM PHYSICIAN, V57, P541
   Sverd J., 2003, J AUTISM DEV DISORD, V36, P1123
   Taylor JL, 2010, J AUTISM DEV DISORD, V40, P1431, DOI 10.1007/s10803-010-1005-z
   Tiger J. H., 2008, BEHAV ANAL PRACTICE, V1, P10
   Tsiouris JA, 2010, J INTELL DISABIL RES, V54, P1, DOI 10.1111/j.1365-2788.2009.01232.x
   Tsiouris JA, 2001, J INTELL DISABIL RES, V45, P115, DOI 10.1046/j.1365-2788.2001.00333.x
   Tsiouris JA, 2003, J INTELL DISABIL RES, V47, P14, DOI 10.1046/j.1365-2788.2003.00456.x
   Tsiouris JA, 2011, J INTELL DISABIL RES, V55, P636, DOI 10.1111/j.1365-2788.2011.01418.x
   Valdovinos MG, 2005, AM J MENT RETARD, V110, P164, DOI 10.1352/0895-8017(2005)110<164:MABSAP>2.0.CO;2
   van der Gaag R. J., 2005, J INDIVIDUAL ADOLESC, V3, P267
   Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008
   Vismara LA, 2010, ANNU REV CLIN PSYCHO, V6, P447, DOI 10.1146/annurev.clinpsy.121208.131151
   Weeden M, 2009, RES AUTISM SPECT DIS, V3, P905, DOI 10.1016/j.rasd.2009.06.004
   Wood JJ, 2011, EVIDENCE-BASED PRACTICES AND TREATMENTS FOR CHILDREN WITH AUTISM, P197, DOI 10.1007/978-1-4419-6975-0_7
   Zafar S., 2008, CLIN NEUROPSYCHIATRY, V5, P9
   Zimmerman M, 2002, AM J PSYCHIAT, V159, P469, DOI 10.1176/appi.ajp.159.3.469
NR 111
TC 2
Z9 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1931-5864
EI 1931-5872
J9 J MENT HEALTH RES IN
JI J. Ment. Health Res. Intellect. Disabil.
PY 2013
VL 6
IS 2
SI SI
BP 74
EP 105
DI 10.1080/19315864.2012.715724
PG 32
WC Education, Special; Psychiatry; Rehabilitation
SC Education & Educational Research; Psychiatry; Rehabilitation
GA AM2FE
UT WOS:000339664200002
ER

PT J
AU Lunsky, Y
   Lake, JK
   Balogh, R
   Weiss, J
   Morris, S
AF Lunsky, Yona
   Lake, Johanna K.
   Balogh, Robert
   Weiss, Jonathan
   Morris, Susan
TI A Review of Canadian Mental Health Research on Intellectual and
   Developmental Disabilities
SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE Canada; mental health; intellectual disability; psychiatric disorder;
   mental health services
ID AUTISM SPECTRUM DISORDERS; INTENSIVE BEHAVIORAL INTERVENTION; ONTARIO
   PSYCHIATRIC-HOSPITALS; EMERGENCY-DEPARTMENT VISITS; DUAL DIAGNOSIS;
   CONSENSUS-GUIDELINES; FAMILY ADJUSTMENT; GENERAL SERVICES; INDIVIDUALS;
   ADULTS
AB This article summarizes Canadian research in "dual diagnosis" spanning the past 20 years and places this research within a historical and policy context. Canadian researchers have made important contributions with regard to understanding inpatient and outpatient mental health services, families, autism, specific disorders and behaviors, aboriginal mental health, forensics, and emergencies. In this article, we aim to summarize several of these contributions. Following a summary of recent research findings, we offer some suggestions and directions for future research in our country.
C1 [Lunsky, Yona; Lake, Johanna K.; Balogh, Robert; Morris, Susan] Ctr Addict & Mental Hlth, Dual Diag Program, Toronto, ON M5V 2B4, Canada.
   [Weiss, Jonathan] York Univ, Dept Psychol, Toronto, ON M3J 2R7, Canada.
RP Lunsky, Y (reprint author), Ctr Addict & Mental Hlth, Dual Diag Program, 501 Queen St W, Toronto, ON M5V 2B4, Canada.
EM yona_lunsky@camh.net
CR ADDINGTON D, 1993, CAN J PSYCHIAT, V38, P134
   Aunos M, 2008, J APPL RES INTELLECT, V21, P320, DOI 10.1111/j.1468-3148.2008.00447.x
   Azimi K., 2011, J DEV DISABILITIES, V17, P47
   Balogh R, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007492
   Balogh R, 2010, J INTELL DISABIL RES, V54, P820, DOI 10.1111/j.1365-2788.2010.01311.x
   Balogh R. S., 2005, J APPL RES INTELLECT, V18, P181
   Balogh RS, 2013, J INTELL DISABIL RES, V57, P226, DOI 10.1111/j.1365-2788.2011.01528.x
   BEBKO JM, 1987, J AUTISM DEV DISORD, V17, P565, DOI 10.1007/BF01486971
   Bradley E, 2006, BRIT J PSYCHIAT, V189, P361, DOI 10.1192/bjp.bp.105.018127
   Bradley EA, 2004, J AUTISM DEV DISORD, V34, P151, DOI 10.1023/B:JADD.0000022606.97580.19
   BRISTOL MM, 1987, J AUTISM DEV DISORD, V17, P469, DOI 10.1007/BF01486964
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Bryson SE, 1998, MENT RETARD DEV D R, V4, P97, DOI 10.1002/(SICI)1098-2779(1998)4:2<97::AID-MRDD6>3.0.CO;2-U
   BURD L, 1994, PUBLIC HEALTH REP, V109, P688
   Burge P., 2009, J DEV DISABILITIES, V15, P96
   Burge P, 2002, CAN J PSYCHIAT, V47, P568
   Burge P, 2008, CAN FAM PHYSICIAN, V54, P568
   Burge P., 1998, SOCIAL WORKER, V66, P15
   Burge P, 2002, CAN J PSYCHIAT, V47, P243
   Cappadocia M. C., 2012, J AUTISM DEV DISORD, V42, P366
   Charlot L, 2011, J INTELL DISABIL RES, V55, P199, DOI 10.1111/j.1365-2788.2010.01294.x
   Chudley A. E., 2005, CANADIAN MED ASS J, V172, P1
   Clark C., 2008, J DEV DISABILITIES, V14, P95
   Clark E., 2004, J FETAL ALCOHOL SYND, V2, P1
   Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
   Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
   Endicott O. R., 1991, PERSONS INTELLECTUAL
   Feldman M., 2002, ETHICAL ISSUES SEXUA, P255
   Feldman M, 2012, J MENT HEALTH RES IN, V5, P66, DOI 10.1080/19315864.2011.587632
   Feldman M. A., 2010, COMPREHENSIVE COMPET
   Feldman MA, 2004, J INTELL DISABIL RES, V48, P60, DOI 10.1111/j.1365-2788.2004.00578.x
   Feldman MA, 2002, BEHAV THER, V33, P377, DOI 10.1016/S0005-7894(02)80034-X
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Fombonne E, 1999, PSYCHOL MED, V29, P769, DOI 10.1017/S0033291799008508
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   FREEMAN NL, 1991, J CHILD PSYCHOL PSYC, V32, P1025, DOI 10.1111/j.1469-7610.1991.tb01927.x
   Friedlander R, 2006, ISR J PSYCHIATR REL, V43, P275
   Friedlander RI, 2004, J INTELL DISABIL RES, V48, P540, DOI 10.1111/j.1365-2788.2004.00622.x
   Gough H, 2012, J POLICY PRACT INTEL, V9, P166, DOI 10.1111/j.1741-1130.2012.00347.x
   Griffiths D., 2003, SOCIOSEXUAL KNOWLEDG
   Griffiths D. M., 1989, CHANGING INAPPROPRIA
   Harris AJR, 2004, J APPL RES INTELLECT, V17, P235, DOI 10.1111/j.1468-3148.2004.00211.x
   Hassan S., 2003, 200301 CRIM RES CTR
   Health Canada Publications, 2003, STAT PROF HLTH 1 NAT
   Hensel J. M., 2011, STUDY HOSP PATIENT S
   Hensel J. M., 2011, J INTELL DISABIL RES, V56, P910, DOI 10.1111/j.1365-2788.2011.01493.x
   Hingsburger D., 1991, HABILITATIVE MENTAL, V10, P51
   Hundert J., 2000, INTENSIVE BEHAV INTE
   Iezzoni LI, 2002, MILBANK Q, V80, P347, DOI 10.1111/1468-0009.t01-1-00007
   Integrated Services for Children Division, 2000, PROGR GUID REG INT E
   Jones J, 2008, J POLICY PRACT INTEL, V5, P219, DOI 10.1111/j.1741-1130.2008.00183.x
   Jones J, 2007, INT J OFFENDER THER, V51, P723, DOI 10.1177/0306624X07299343
   Jones J., 2007, J DEV DISABILITIES
   Lazoff T, 2010, CAN J PSYCHIAT, V55, P715
   Lopes V., 2008, J DEV DISABILITIES, V14, P99
   Lougheed D., 2011, CLIN B DEV DISABILIT, V22, P1
   Lunsky Y, 2009, AJIDD-AM J INTELLECT, V114, P52, DOI 10.1352/2009.114:52-60
   Lunsky Y, 2006, PSYCHIAT SERV, V57, P77, DOI 10.1176/appi.ps.57.1.77
   Lunsky Y, 2011, J INTELL DISABIL RES, V55, P242, DOI 10.1111/j.1365-2788.2010.01307.x
   Lunsky Y, 2007, J APPL RES INTELLECT, V20, P439, DOI 10.1111/j.1468-3148.2007.00384.x
   Lunsky Y, 2011, PSYCHIAT SERV, V62, P830, DOI 10.1176/appi.ps.62.8.830
   Lunsky Y, 2008, J INTELL DISABIL RES, V52, P1003, DOI 10.1111/j.1365-2788.2008.01049.x
   Lunsky Y, 2012, CAN J PSYCHIAT, V57, P601
   Lunsky Y, 2011, AM J EMERG MED, V29, P463, DOI 10.1016/j.ajem.2010.12.028
   Lunsky Y, 2009, RES AUTISM SPECT DIS, V3, P1006, DOI 10.1016/j.rasd.2009.06.005
   Lunsky Y, 2012, PSYCHIAT SERV, V63, P287, DOI 10.1176/appi.ps.201100124
   Lunsky Y, 2010, CAN J PSYCHIAT, V55, P721
   MacMillan HL, 2003, CAN J PUBLIC HEALTH, V94, P168
   Martin L., 2007, J DEV DISABIL, V13, P89
   Masotti P, 2006, PLOS MED, V3, P24, DOI 10.1371/journal.pmed.0030008
   Masotti P., 2003, J FETAL ALCOHOL RES, V1, pe17
   McCain M, 1999, EARLY YEARS STUDY FI
   McConnell D., 2009, BRIT J LEARN DISABIL, V37, P66, DOI 10.1111/j.1468-3156.2008.00526.x
   Mental Health Commission of Canada, 2012, CHANG DIR CHANG LIV
   Minnes P, 2007, J APPL RES INTELLECT, V20, P539, DOI 10.1111/j.1468-3148.2007.00364.x
   Minnes P. M., 2004, J DEV DISABILITIES, V11, P47
   Morin D, 2010, CAN PSYCHOL, V51, P185, DOI 10.1037/a0020184
   Nachshen J. S., 2005, MENTAL HLTH ASPECTS, V8, P105
   Nachshen JS, 2003, J INTELL DISABIL RES, V47, P285, DOI 10.1046/j.1365-2788.2003.00490.x
   Nachshen JS, 2005, J INTELL DISABIL RES, V49, P889, DOI 10.1111/j.1365-2788.2005.00721.x
   National Center on Birth Defects and Developmental Disabilities Center for Disease Control & Department of Health and Human Services, 2004, FETAL ALCOHOL SYNDRO
   Perry A, 2008, RES AUTISM SPECT DIS, V2, P621, DOI 10.1016/j.rasd.2008.01.002
   Perry A., 2004, J DEV DISABILITIES, V11, P1
   Perry A., 2002, J DEV DISABILITIES, V9, P121
   Perry A, 2006, BEHAV INTERVENT, V21, P85, DOI 10.1002/bin.212
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Popova S, 2011, CAN J PUBLIC HEALTH, V102, P336
   Raina P, 2010, RES DEV DISABIL, V31, P218, DOI 10.1016/j.ridd.2009.09.008
   Roos NP, 1999, MED CARE, V37, pJS27, DOI 10.1097/00005650-199906001-00007
   Saeed H, 2003, J BEHAV HEALTH SER R, V30, P406, DOI 10.1007/BF02287428
   Shooshtari S., 2011, INT J FAMILY MED, DOI [10.1155/2011/319574, DOI 10.1155/2011/319574]
   Solish A, 2008, RES AUTISM SPECT DIS, V2, P728, DOI 10.1016/j.rasd.2008.03.001
   Stade Brenda, 2009, Can J Clin Pharmacol, V16, pe91
   Statistics Canada, 2010, AB POP SURP ON MILL
   Statistics Canada, 2011, 2006 CENS LANG
   Streissguth A. P., 1996, UNDERSTANDING OCCURR
   Sullivan WF, 2006, CAN FAM PHYSICIAN, V52, P1410
   Sullivan WF, 2011, CAN FAM PHYSICIAN, V57, P541
   Syeda M., 2011, J DEV DISABILITIES, V17, P64
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Temple V, 2010, J INTELL DISABIL RES, V54, P573, DOI 10.1111/j.1365-2788.2010.01282.x
   Tetroe J., 2007, FOCUS TECHNICAL BRIE, V18, P1
   Trute B, 2010, J INTELLECT DEV DIS, V35, P36, DOI 10.3109/13668250903496328
   Viecili MA, 2010, J MENT HEALTH RES IN, V3, P190, DOI 10.1080/19315864.2010.524725
   Watson S. L., 2008, J DEV DISABILITIES, V14, P1
   Watson SL, 2011, INT REV RES DEV DISA, V41, P31, DOI 10.1016/B978-0-12-386495-6.00002-3
   Weeks LE, 2009, J POLICY PRACT INTEL, V6, P180, DOI 10.1111/j.1741-1130.2009.00222.x
   Weiss J, 2010, J MENT HEALTH RES IN, V3, P145, DOI 10.1080/19315864.2010.490617
   Weiss JA, 2011, J MENT HEALTH RES IN, V4, P158, DOI 10.1080/19315864.2011.599013
   Weiss JA, 2009, J APPL RES INTELLECT, V22, P354, DOI 10.1111/j.1468-3148.2008.00468.x
   Weiss JA, 2012, AUTISM, V16, P261, DOI 10.1177/1362361311422708
   Weiss JA, 2011, J CHILD FAM STUD, V20, P521, DOI 10.1007/s10826-010-9419-y
   Weiss JA, 2008, AM J MENT RETARD, V113, P241, DOI 10.1352/0895-8017(2008)113[241:ROSOFM]2.0.CO;2
   Weiss JA, 2010, CAN PSYCHOL, V51, P177, DOI 10.1037/a0019733
   White S. E., 2009, J DEV DISABILITIES, V15, P89
   White SE, 2010, J MENT HEALTH RES IN, V3, P117, DOI 10.1080/19315864.2010.487632
   White S. E., 2011, J CHILD FAM STUD, V21, P457
NR 118
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1931-5864
EI 1931-5872
J9 J MENT HEALTH RES IN
JI J. Ment. Health Res. Intellect. Disabil.
PY 2013
VL 6
IS 2
SI SI
BP 106
EP 126
DI 10.1080/19315864.2012.700685
PG 21
WC Education, Special; Psychiatry; Rehabilitation
SC Education & Educational Research; Psychiatry; Rehabilitation
GA AM2FE
UT WOS:000339664200003
ER

PT J
AU Torr, J
AF Torr, Jennifer
TI Intellectual Disability and Mental Ill Health: A View of Australian
   Research
SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE intellectual disabilities; mental health; prevalence; lifespan;
   psychiatric assessment; psychiatric management; service provision;
   Australia
ID DEVELOPMENTAL BEHAVIOR CHECKLIST; YOUNG-PEOPLE; PSYCHIATRIC-CARE;
   POPULATION PREVALENCE; EMOTIONAL DISTURBANCE; CHILDREN; PSYCHOPATHOLOGY;
   DEPRESSION; ADULTS; AUTISM
AB This general review situates Australian research within a framework that quantifies and describes mental health needs of the population with intellectual disabilities across the life span, surveys service provision, and develops the evidence base to inform clinicians regarding assessment and management of psychopathology and psychiatric disorder in people with intellectual disabilities. In particular, Australian research has examined the prevalence, nature, associated factors, and trajectory of clinically significant psychopathology from childhood to adulthood. The Developmental Behavior Checklist and a suite of versions, including an adult version, have proven to be robust instruments in identifying and describing psychopathology in people with intellectual disabilities. Australian researchers have also examined aspects of psychiatric assessment in a population with cognitive and communication impairments, which has direct relevance to clinical practice. Surveys and audits of policy, real-life practice, and service structure and provision have identified serious deficiencies in the training of health professionals and the provision of mental health care to people of all ages with intellectual disabilities and mental ill health. In light of the weight of the evidence, state and federal governments are developing new service models and there are increasing opportunities for professional education and training.
C1 [Torr, Jennifer] Monash Univ, Ctr Dev Disabil Hlth Victoria, Notting Hill, Vic 3168, Australia.
RP Torr, J (reprint author), Monash Univ, Ctr Dev Disabil Hlth Victoria, Omnico Business Ctr, Bldg One,270 Ferntree Gully Rd, Notting Hill, Vic 3168, Australia.
EM Jenny.Torr@monash.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bennett C., 2000, AUSTRALAS PSYCHIATRY, V8, P238, DOI 10.1046/j.1440-1665.2000.00269.x
   Bontempo Daniel E, 2008, J Appl Meas, V9, P265
   Brereton A., 2007, DEV BEHAV CHECKLIST
   Brereton A. V., 2005, PRESHOOLERS AUTISM E
   Brereton AV, 2006, J AUTISM DEV DISORD, V36, P863, DOI 10.1007/s10803-006-0125-y
   Brereton AV, 2002, J AM ACAD CHILD PSY, V41, P1369, DOI 10.1097/01.CHI.0000024838.94814.A5
   BURVILL PW, 1988, AUST NZ J PSYCHIAT, V22, P436, DOI 10.3109/00048678809161354
   Cain N., 2010, MENTAL HLTH SERVICES, P37
   Carter W. J., 2006, REPORT HOUNOURABLE W
   Commonwealth of Australia, 2009, HELP CHILDR AUT
   Commonwealth of Australia, 2009, BETT START CHILDR DI
   d'Abrera C., 2008, INDEPENDENT PSYCHIAT
   Davis JP, 1997, AUST NZ J PSYCHIAT, V31, P243, DOI 10.3109/00048679709073827
   Dekker MC, 2002, J AUTISM DEV DISORD, V32, P601, DOI 10.1023/A:1021263216093
   Dekker MC, 2002, J INTELL DISABIL RES, V46, P61, DOI 10.1046/j.1365-2788.2002.00353.x
   Department of Human Services, 2009, MENT HLTH MATT VICT
   EDWARDS N, 2007, J INTELL DISABIL RES, V50, P75
   Einfeld S., 1999, J INTELLECT DEV DIS, V24, P349, DOI 10.1080/13668259900034111
   Einfeld S, 2007, J APPL RES INTELLECT, V20, P384, DOI 10.1111/j.1468-3148.2007.00381.x
   EINFELD S L, 1991, Australia and New Zealand Journal of Developmental Disabilities, V17, P147
   Einfeld SL, 2010, J MENT HEALTH RES IN, V3, P177, DOI 10.1080/19315864.2010.519098
   EINFELD SL, 1992, AUST NZ J PSYCHIAT, V26, P48, DOI 10.3109/00048679209068309
   EINFELD SL, 1994, AM J MED GENET, V51, P386, DOI 10.1002/ajmg.1320510417
   Einfeld SL, 1996, J INTELL DISABIL RES, V40, P99, DOI 10.1111/j.1365-2788.1996.tb00611.x
   Einfeld SL, 2006, JAMA-J AM MED ASSOC, V296, P1981, DOI 10.1001/jama.296.16.1981
   Einfeld SL, 1996, J INTELL DISABIL RES, V40, P91, DOI 10.1111/j.1365-2788.1996.tb00610.x
   Einfeld SL, 1999, AM J MED GENET, V82, P123, DOI 10.1002/(SICI)1096-8628(19990115)82:2<123::AID-AJMG4>3.0.CO;2-C
   Einfeld SL, 1999, J INTELL DISABIL RES, V43, P408, DOI 10.1046/j.1365-2788.1999.043005408.x
   Einfeld SL, 2010, J MENT HEALTH RES IN, V3, P202, DOI 10.1080/19315864.2010.524973
   Emerson E, 2010, J CHILD PSYCHOL PSYC, V51, P583, DOI 10.1111/j.1469-7610.2009.02179.x
   Emerson E, 2008, AUST NZ J PUBL HEAL, V32, P53, DOI 10.1111/j.1753-6405.2008.00166.x
   Emerson E, 2010, SOC PSYCH PSYCH EPID, V45, P579, DOI 10.1007/s00127-009-0100-y
   Emerson E, 2011, J CHILD PSYCHOL PSYC, V52, P1184, DOI 10.1111/j.1469-7610.2011.02413.x
   Gray KM, 2005, AUST NZ J PSYCHIAT, V39, P378, DOI 10.1111/j.1440-1614.2005.01585.x
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
   Hallmayer JF, 2005, AM J HUM GENET, V77, P468, DOI 10.1086/432816
   Herring S, 2006, J INTELL DISABIL RES, V50, P874, DOI 10.1111/j.1365-2788.2006.00904.x
   Human Rights and Equal Opportunity Commission, 1993, REPORT NATL INQUIRY, P659
   Jaunernig R., 1995, AUSTR NZ J DEV DISAB, V20, P51
   Jess G, 2008, J APPL RES INTELLECT, V21, P183, DOI 10.1111/j.1468-3148.2007.00394.x
   KPMG, 2009, NSW HLTH AN COSTS BE
   Lennox N, 1996, AUST NZ J PSYCHIAT, V30, P774, DOI 10.3109/00048679609065044
   Lennox N, 1995, AUST NZ J PSYCHIAT, V29, P632, DOI 10.3109/00048679509064978
   Lennox N., 2002, NOT SAME PAGE REPORT
   McCabe MP, 2006, J INTELL DISABIL RES, V50, P239, DOI 10.1111/j.1365-2788.2005.00772.x
   McGillivray JA, 2008, RES DEV DISABIL, V29, P524, DOI 10.1016/j.ridd.2007.09.005
   McGillivray JA, 2007, RES DEV DISABIL, V28, P59, DOI 10.1016/j.ridd.2005.11.001
   Mohr C, 2005, J INTELL DISABIL RES, V49, P469, DOI 10.1111/j.1365-2788.2005.00701.x
   Mohr C., 2012, J INTELLECT DEV DIS, P1
   Morgan VA, 2008, BRIT J PSYCHIAT, V193, P364, DOI 10.1192/bjp.bp.107.044461
   Moseley DS, 2011, J MENT HEALTH RES IN, V4, P229, DOI 10.1080/19315864.2011.595535
   PARMENTER T R, 1988, Australia and New Zealand Journal of Developmental Disabilities, V14, P9
   Phillips A, 2004, J INTELL DISABIL RES, V48, P142, DOI 10.1111/j.1365-2788.2004.00503.x
   RYAN M, 1991, Australia and New Zealand Journal of Developmental Disabilities, V17, P177
   SACHDEV PS, 1991, MED J AUSTRALIA, V155, P75
   Taffe JR, 2007, AM J MENT RETARD, V112, P31, DOI 10.1352/0895-8017(2007)112[31:SFOTDB]2.0.CO;2
   Thomas S., 2010, DISABILITY MENTAL HL
   Tonge B, 2000, AUST NZ J PSYCHIAT, V34, P80, DOI 10.1046/j.1440-1614.2000.00695.x
   Tonge B, 2006, J AM ACAD CHILD PSY, V45, P561, DOI 10.1097/01.chi.0000205701.48324.26
   Tonge B., 2011, SCREEING DEPRESSION
   Tonge BJ, 1996, J INTELL DISABIL RES, V40, P198, DOI 10.1046/j.1365-2788.1996.771771.x
   Torr J, 2008, J INTELL DISABIL RES, V52, P930, DOI 10.1111/j.1365-2788.2008.01103.x
   Torr J., 2000, PSYCHIAT INTELLECTUA
   Torr J, 2008, AUST NZ J PSYCHIAT, V42, P890, DOI 10.1080/00048670802345474
   Webber LS, 2011, J APPL RES INTELLECT, V24, P495, DOI 10.1111/j.1468-3148.2011.00635.x
   White P, 2005, AUST NZ J PSYCHIAT, V39, P395, DOI 10.1111/j.1440-1614.2005.01587.x
   World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 68
TC 2
Z9 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1931-5864
EI 1931-5872
J9 J MENT HEALTH RES IN
JI J. Ment. Health Res. Intellect. Disabil.
PY 2013
VL 6
IS 2
SI SI
BP 159
EP 178
DI 10.1080/19315864.2012.700686
PG 20
WC Education, Special; Psychiatry; Rehabilitation
SC Education & Educational Research; Psychiatry; Rehabilitation
GA AM2FE
UT WOS:000339664200005
ER

PT J
AU Geier, DA
   Kern, JK
   Geier, MR
AF Geier, David A.
   Kern, Janet K.
   Geier, Mark R.
TI A Comparison of the Autism Treatment Evaluation Checklist (ATEC) and the
   Childhood Autism Rating Scale (CARS) for the Quantitative Evaluation of
   Autism
SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE ASD; Asperger's; autistic disorder; PDD-NOS; CARS; ATEC
ID BEHAVIOR CHECKLIST; SPECTRUM DISORDERS; CHILDREN; SYMPTOMS; VALIDITY;
   DIAGNOSIS; DEFICITS
AB The purpose of this study was to evaluate scores generated from the Autism Treatment Evaluation Checklist (ATEC), a parent-rated measure, and those derived from professionally completed Childhood Autism Rating Scale (CARS) evaluations. A cohort of 56 participants diagnosed with an autism spectrum disorder was used for the study, and each child was evaluated independently by the parent using the ATEC and a health care professional using the CARS. The Spearman's rank correlation statistic. was used to evaluate the correlation between ATEC and CARS scores. It was observed that there was a significant correlation between total ATEC and CARS scores (rho = .71). Specific domains in the ATEC evaluation significantly correlated with CARS scores. Sensitivity, specificity, and receiver operating characteristic confirmed the association between CARS and ATEC domains. The results help to validate the utility of the parentally completed ATEC in comparison with an established, professional-related measure of autism.
C1 [Geier, David A.; Kern, Janet K.] Inst Chron Illnesses Inc, Silver Spring, MD 20905 USA.
   [Kern, Janet K.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
   [Geier, Mark R.] ASD Ctr LLC, Silver Spring, MD USA.
RP Kern, JK (reprint author), Inst Chron Illnesses Inc, 14 Redgate Court, Silver Spring, MD 20905 USA.
EM jkern@dfwair.net
CR Adams JB, 2011, BMC GASTROENTEROL, V11, DOI 10.1186/1471-230X-11-22
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Atladottir HO, 2010, ARCH PEDIAT ADOL MED, V164, P470, DOI 10.1001/archpediatrics.2010.9
   Ballabriga M. C., 1994, REV PSIQUIATRIA INFA, V4, P254
   Banaschewski T, 2011, NERVENARZT, V82, P573, DOI 10.1007/s00115-010-3239-6
   Chlebowski C, 2010, J AUTISM DEV DISORD, V40, P787, DOI 10.1007/s10803-009-0926-x
   Critchfield JW, 2011, GASTROENT RES PRACT, DOI 10.1155/2011/161358
   EAVES RC, 1993, J ABNORM CHILD PSYCH, V21, P481, DOI 10.1007/BF00916315
   FREEMAN BJ, 1986, J AM ACAD CHILD PSY, V25, P130, DOI 10.1016/S0002-7138(09)60610-5
   GARFIN DG, 1988, J AUTISM DEV DISORD, V18, P367, DOI 10.1007/BF02212193
   Hardan AY, 2003, J CHILD NEUROL, V18, P317, DOI 10.1177/08830738030180050801
   Jarusiewicz B., 2002, J NEUROTHERAPY, V6, P39, DOI [10.1300/j184v06n04_05, DOI 10.1300/J184V06N04_05]
   Kern JK, 2010, BIOMETALS, V23, P1043, DOI 10.1007/s10534-010-9349-6
   KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
   Lonsdale D, 2002, NEUROENDOCRINOL LETT, V23, P303
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Magiati I, 2011, J INTELL DISABIL RES, V55, P302, DOI 10.1111/j.1365-2788.2010.01359.x
   Minshew NJ, 2004, NEUROLOGY, V63, P2056
   Nikolov RN, 2009, J AUTISM DEV DISORD, V39, P405, DOI 10.1007/s10803-008-0637-8
   Pereira A, 2008, J PEDIAT, V84, P487, DOI [10.2223/JPED.1828, 10.1590/S0021-75572008000700004]
   Perry A, 2005, J AUTISM DEV DISORD, V35, P625, DOI 10.1007/s10803-005-0006-9
   Piek JP, 2004, HUM MOVEMENT SCI, V23, P475, DOI 10.1016/j.humov.2004.08.019
   Provost Beth, 2007, Phys Occup Ther Pediatr, V27, P21, DOI 10.1300/J006v27n03_03
   Rellini E, 2004, J AUTISM DEV DISORD, V34, P703, DOI 10.1007/s10803-004-5290-2
   Rimland B., 1999, AUTISM TREATMENT EVA
   Schieve L. A., 2011, RES DEV DISABIL, V33, P467
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Schopler E., 1994, CHILDHOOD AUTISM RAT
   SEVIN JA, 1991, J AUTISM DEV DISORD, V21, P417, DOI 10.1007/BF02206868
   South M, 2002, J AUTISM DEV DISORD, V32, P593, DOI 10.1023/A:1021211232023
   TEAL MB, 1986, J AUTISM DEV DISORD, V16, P485, DOI 10.1007/BF01531713
   Williams PG, 2004, J SLEEP RES, V13, P265
NR 32
TC 1
Z9 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1931-5864
EI 1931-5872
J9 J MENT HEALTH RES IN
JI J. Ment. Health Res. Intellect. Disabil.
PY 2013
VL 6
IS 4
BP 255
EP 267
DI 10.1080/19315864.2012.681340
PG 13
WC Education, Special; Psychiatry; Rehabilitation
SC Education & Educational Research; Psychiatry; Rehabilitation
GA AM2WP
UT WOS:000339712100001
ER

PT J
AU Ng, R
   Lai, P
   Levitin, DJ
   Bellugi, U
AF Ng, Rowena
   Lai, Philip
   Levitin, Daniel J.
   Bellugi, Ursula
TI Musicality Correlates With Sociability and Emotionality in Williams
   Syndrome
SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE social-emotionality; musicality; Williams syndrome
ID AUTISM SPECTRUM DISORDERS; YOUNG-CHILDREN; INDIVIDUALS; BEHAVIOR;
   ANXIETY; HYPERSOCIABILITY; RESPONSIVENESS; ADOLESCENTS; PERCEPTION;
   PHENOTYPE
AB Williams syndrome (WS) is a neurogenetic developmental disorder characterized by peaks and valleys of cognitive abilities. One peak that has been understudied is the affinity that many individuals with WS have with music. It remains unknown whether their high levels of musical interest, skill, and expressivity are related to their sociable personality or their verbal intelligence. We examined the relationships between musicality (musical interest, creativity, and expressivity), sociability (social-emotionality, social approach), and language comprehension in WS and typically developing (TD) controls. Findings suggest that emotion-expressivity through music in WS may be linked to sensitivity and responsivity to emotions of others, whereas general interest in music may be related to greater linguistic capacity in TD individuals. Musicality and sociability may be more closely related in WS relative to typical development. Implications for future interventions for this neurodevelopmental condition are discussed.
C1 [Ng, Rowena; Bellugi, Ursula] Salk Inst Biol Studies, Cognit Neurosci Lab, La Jolla, CA 92037 USA.
   [Lai, Philip] San Diego State Univ, Univ Calif San Diego, Joint Doctoral Program Language & Communicat Diso, San Diego, CA 92182 USA.
   [Levitin, Daniel J.] McGill Univ, Dept Psychol, Montreal, PQ H3A 2T5, Canada.
RP Ng, R (reprint author), Salk Inst Biol Studies, Cognit Neurosci Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA.
EM bellugi@salk.edu
CR American Academy of Pediatrics Committee on Genetics, 2001, HEALTH CARE SUPERVIS, V107, P1192
   Bellugi U., 1990, DEV PSYCHOPATHOL, V2, P367, DOI DOI 10.1017/S0954579400005782
   Bhatara A, 2010, AUTISM RES, V3, P214, DOI 10.1002/aur.147
   Bloom A., 1997, 60 MINUTES
   Chedd G., 2001, SCIENTIFIC AMERICAN
   Doyle TF, 2004, AM J MED GENET A, V124A, P263, DOI 10.1002/ajmg.a.20416
   Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd
   Dykens EM, 2005, AM J MENT RETARD, V110, P346, DOI 10.1352/0895-8017(2005)110[346:MAAIWS]2.0.CO;2
   Dykens EM, 2003, DEV NEUROPSYCHOL, V23, P291, DOI 10.1207/S15326942DN231&2_13
   Finnigan E, 2010, AUTISM, V14, P321, DOI 10.1177/1362361309357747
   GALABURDA AM, 1994, NEUROREPORT, V5, P753, DOI 10.1097/00001756-199403000-00004
   Haas BW, 2010, NEUROPSYCHOLOGIA, V48, P1283, DOI 10.1016/j.neuropsychologia.2009.12.030
   Hille Katrin, 2011, Adv Cogn Psychol, V7, P1, DOI 10.2478/v10053-008-0082-4
   Jarvinen-Pasley A, 2010, NEUROPSYCHOLOGIA, V48, P456, DOI 10.1016/j.neuropsychologia.2009.10.003
   Jarvinen-Pasley A, 2008, DEV PSYCHOPATHOL, V20, P1, DOI 10.1017/S0954579408000011
   Jones W, 2000, J COGNITIVE NEUROSCI, V12, P30, DOI 10.1162/089892900561968
   Katagiri J, 2009, J MUSIC THER, V46, P15
   Kent J., 2011, EMBRACEABLE
   Kim J, 2009, AUTISM, V13, P389, DOI 10.1177/1362361309105660
   Klein-Tasman BP, 2009, J DEV BEHAV PEDIATR, V30, P289, DOI 10.1097/DBP.0b013e3181ad1f9a
   Klein-Tasman BP, 2003, DEV NEUROPSYCHOL, V23, P269, DOI 10.1207/S15326942DN231&2_12
   Korenberg JR, 2000, J COGNITIVE NEUROSCI, V12, P89, DOI 10.1162/089892900562002
   Lai P. T., 2009, THESIS
   Lenhoff HM, 1997, SCI AM, V277, P68
   Levitin D. J., 2006, JOURNAL OF CHILD PSY, V46, P514
   Levitin D. J., 2006, WILLIAMSBEUREN SYNDR, P343
   Levitin DJ, 2005, ANN NY ACAD SCI, V1060, P325, DOI 10.1196/annals.1360.027
   Levitin DJ, 2003, NEUROIMAGE, V18, P74, DOI 10.1006/nimg.2002.1297
   Levitin DJ, 2004, CHILD NEUROPSYCHOL, V10, P223, DOI 10.1080/09297040490909288
   Levitin DJ, 2012, NEURON, V73, P633, DOI 10.1016/j.neuron.2012.01.017
   Lim HA, 2010, J MUSIC THER, V47, P2
   Losh M., 2000, NARRAT INQ, V10, P1
   Quintin EM, 2011, J AUTISM DEV DISORD, V41, P1240, DOI 10.1007/s10803-010-1146-0
   Quintin E.-M., 2012, CHILD NEUROPSYCHOL, V19, P250
   Reis SM, 2003, EXCEPT CHILDREN, V69, P293
   Sellinger MH, 2006, J DEV PHYS DISABIL, V18, P59, DOI 10.1007/s10882-006-9006-8
   Tager-Flusberg H, 2000, COGNITION, V76, P59, DOI 10.1016/S0010-0277(00)00069-X
   Thornton-Wells TA, 2010, AJIDD-AM J INTELLECT, V115, P172, DOI 10.1352/1944-7588-115.172
   Woodruff-Borden J, 2010, AM J MED GENET C, V154C, P277, DOI 10.1002/ajmg.c.30259
   Zitzer-Comfort C, 2007, DEVELOPMENTAL SCI, V10, P755, DOI 10.1111/j.1467-7687.2007.00626.x
NR 40
TC 2
Z9 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1931-5864
EI 1931-5872
J9 J MENT HEALTH RES IN
JI J. Ment. Health Res. Intellect. Disabil.
PY 2013
VL 6
IS 4
BP 268
EP 279
DI 10.1080/19315864.2012.683932
PG 12
WC Education, Special; Psychiatry; Rehabilitation
SC Education & Educational Research; Psychiatry; Rehabilitation
GA AM2WP
UT WOS:000339712100002
ER

PT J
AU Babic, MM
   Franc, I
   Leutar, Z
AF Babic, Marina Milic
   Franc, Iva
   Leutar, Zdravka
TI EARLY INTERVENTION EXPERIENCES OF PARENTS OF CHILDREN WITH DEVELOPMENTAL
   DISABILITIES
SO LJETOPIS SOCIJALNOG RADA
LA Croatian
DT Article
DE early intervention; children with developmental disabilities; family;
   social work
ID FAMILIES; PERSPECTIVE; AUTISM
AB Early intervention as a mode of support to children and families in early years of a child's life is aimed at enhancing the child's development. In addition to being focused on the child, early intervention also functions as a support to family members. The aim of this paper is to explore experiences of parents of children with developmental disabilities with the early intervention process. The conducted qualitative research included parents of children with developmental disabilities (N=13).
   Research results indicate which areas parents see as important for a successful early intervention and they include an interdisciplinary approach, competence and motivation of professionals and cooperation with families. Parents have identified the following disadvantages within the system: the lack of timely support and information, unprofessionalism and organisational difficulties. Parents describe social work in early intervention through experiences marked with parents' dissatisfaction with obtained information, i.e. relationship with professionals and the organisation of work. However, parents recognise the importance of the involvement of social work in the early intervention system and they describe the role of social workers as coordinators of the early support, providers of information and counsellors. Obtained findings may serve as guidelines for improving the existing early intervention system and for actualisation of the social work profession, the active participation of which can contribute to the improvement of early intervention for children and families.
C1 [Babic, Marina Milic; Franc, Iva; Leutar, Zdravka] Univ Zagreb, Fac Law, Dept Social Work, Zagreb 41000, Croatia.
RP Babic, MM (reprint author), Univ Zagreb, Fac Law, Dept Social Work, Zagreb 41000, Croatia.
EM marina.milic.babic@pravo.hr; avifranc@gmail.com; zdravka.leutar@pravo.hr
CR Alisauskiene S., 2009, BE PROFESSIONAL EARL
   Alliston L., 2007, PRINCIPLES PRACTICES
   Ammerman R., 1997, HDB PREVENTION TREAT, P157
   Bailey D. B., 2006, J EARLY INTERVENTION, V28, P226
   Bailey D. B., 2004, PEDIATRICS, V4, P886
   Bailey D. B., 1998, EXCEPT CHILDREN, V3, P1
   Blackman JA, 2002, INFANT YOUNG CHILD, V15, P11
   Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
   Brozovic B, 2003, BITI RODITELJ, P309
   Carlhed C, 2003, BRIT J DEV DISABIL, V49, P69
   Chang CL, 2007, EXPERT SYST APPL, V33, P407, DOI 10.1016/j.eswa.2006.05.007
   Cvetko J., 2004, AUTIZAM CASOPIS AUTI, V1, P19
   Dale N., 2004, WORKING FAMILIES CHI
   Darling R. B., 2007, ORDINARY FAMILIES SP, V3rd
   Dowling M., 2012, PARENTS PARTICIPATIO
   Dunst CJ, 2002, EXCEPT CHILDREN, V68, P361
   Franz P., 2000, INFANTS YOUNG CHILDR, V12, P32
   Gillham B., 2005, RES INTERVIEWING RAN
   Gupta A., 2004, ASIA PACIFIC DISABIL, V1, P22
   Guralnick MJ, 2011, INFANT YOUNG CHILD, V24, P6, DOI 10.1097/IYC.0b013e3182002cfe
   Heiman T, 2002, J DEV PHYS DISABIL, V14, P159, DOI 10.1023/A:1015219514621
   Helmink J. H., 2011, J EVAL CLIN PRACT, V18, P682
   Hodapp R. M, 2005, PARENTING ECOLOGICAL
   Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
   Iversen D. M., 2003, PEDIAT PHYS THERAPY, V15, P23
   Ivgac Pavlisa J., 2010, DRUS ISTRAZ, V1-2, P279
   Kosicek T., 2009, HRVATSKA REVIJA REHA, V1, P1
   Kraljevic R., 2010, HRVATSKA REVIJA REHA, V47, P41
   Sarimski K, 2013, EUR J SPEC NEEDS EDU, V28, P362, DOI 10.1080/08856257.2013.797706
   Leutar Zdravka, 2011, J Soc Work Disabil Rehabil, V10, P1, DOI 10.1080/1536710X.2011.546284
   Leutar Z, 2007, LJETOP SOC RADA, V14, P27
   Leutar Z., 2008, OBITELJI OSOBA INVAL
   Leutar Z., 2012, ZBORNIK RADOVA ZANST, P85
   Ljubesic M., 2004, GYNAECOLOGIA PERINAT, V13, P57
   Ljubesic M, 2012, PAEDIATR CROAT, V56, P202
   Ljubsic M., 2009, ZBORNIK SAZETAKA 1 H, P71
   Mackintosh VH, 2012, FOCUS AUTISM DEV DIS, V27, P51, DOI 10.1177/1088357611423542
   Majnemer A, 1998, Semin Pediatr Neurol, V5, P62, DOI 10.1016/S1071-9091(98)80020-X
   Mejaski Bosnjak V., 2013, TIMSKA DIJAGNOSTIKA
   Merkas M., 2011, ANALIZA STANJA PRAVA
   Middleton L., 1998, CHILD FAMILY SOCIAL, V3, P239
   Milas G., 2005, INSTRAZIVACKE METODE
   Milic Babic M., 2010, THESIS PRAVNI FAKULT
   Moeller MP, 2007, EAR HEARING, V28, P729
   Ngo H, 2012, SINGAP MED J, V53, P451
   Pelchat D, 1999, INT J NURS STUD, V36, P465, DOI 10.1016/S0020-7489(99)00047-4
   Prezant FP, 2006, DISABIL SOC, V21, P31, DOI 10.1080/09687590500373767
   Pritzlaff A., 2001, EXAMING COPING STRAT
   Ramey CT, 1998, AM PSYCHOL, V53, P109, DOI 10.1037/0003-066X.53.2.109
   Richardson K., 2011, DEALING STIGMA PAREN
   Roguljic G., 2010, ZADOVOLJSTVO RODITEL
   Scarborough AA, 2004, EXCEPT CHILDREN, V70, P469
   Sivric M, 2010, LJETOP SOC RADA, V17, P241
   Sloper R, 1998, CHILD CARE HLTH DEV, V2, P85
   Smith J. D., 2010, J TEACHER ED DIVISIO, V33, P131
   Spiker D, 2005, INT ISSUE EARLY INTE, P305
   Spittle A. J., 2012, EARLY DEV INTERVENTI
   Turnbull A. P., 2011, J EARLY INTERVENTION, V33, P200
   Vuksan Perovic V., 2013, ISKUSTVA SOCIJALNIH
NR 59
TC 0
Z9 0
PU UNIV ZAGREB FAC LAW DEPT SOCIAL WORK
PI ZAGREB
PA NAZOROVA 51, ZAGREB, 10000, CROATIA
SN 1846-5412
J9 LJETOP SOC RADA
JI Ljetop. Soc. Rada
PY 2013
VL 20
IS 3
BP 453
EP 480
PG 28
WC Social Work
SC Social Work
GA AM3UW
UT WOS:000339779300006
ER

PT J
AU Horovitz, M
   Matson, JL
   Hattier, MA
   Tureck, K
   Bamburg, JW
AF Horovitz, Max
   Matson, Johnny L.
   Hattier, Megan A.
   Tureck, Kimberly
   Bamburg, Jay W.
TI Challenging Behaviors in Adults With Intellectual Disability: The
   Effects of Race and Autism Spectrum Disorders
SO JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE race; ethnicity; challenging behaviors; autism spectrum disorders;
   ASD-BPA; intellectual disability
ID PERVASIVE DEVELOPMENTAL DISORDER; PDD-NOS; TOTAL POPULATION;
   YOUNG-CHILDREN; RISK-FACTORS; PREVALENCE; INFANTS; DIAGNOSIS;
   PSYCHOPATHOLOGY; STEREOTYPIES
AB Rates of challenging behaviors were assessed in 175 adults with intellectual disability (ID) or ID and a comorbid autism spectrum disorder (ASD). The relationship between ASD diagnosis, race, and challenging behaviors was assessed using the Autism Spectrum Disorders-Behavior Problems for Adults (ASD-BPA). Those with ASD and ID were found to exhibit significantly more challenging behaviors than those with ID alone. No significant main effect of race was found. However, a significant interaction between ASD diagnosis and race was found: In those with ASD, Caucasian participants exhibited more challenging behaviors than African Americans, whereas the opposite held true in those without ASD. Specific subscales of the ASD-BPA were also examined, with a significant interaction found on the Stereotypy subscale. Results and their implications are discussed.
C1 [Horovitz, Max; Matson, Johnny L.; Hattier, Megan A.; Tureck, Kimberly] Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
   [Bamburg, Jay W.] Pinecrest Supports & Serv Ctr, Pineville, LA USA.
RP Matson, JL (reprint author), Louisiana State Univ, Dept Psychol, 234 Audubon Hall, Baton Rouge, LA 70803 USA.
EM johnmatson@aol.com
CR American Psychiatric Association, 2000, DIAGNOSTIC AND STATI
   Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators, 2007, MMWR SURVEILL SUMM, V56, P12
   Baghdadli A, 2003, J INTELL DISABIL RES, V47, P622, DOI 10.1046/j.1365-2788.2003.00507.x
   BallabanGil K, 1996, PEDIATR NEUROL, V15, P217, DOI 10.1016/S0887-8994(96)00219-6
   Beadle-Brown J, 2006, J APPL RES INTELLECT, V19, P317, DOI 10.1111/j.1468-3148.2005.00289.x
   Bertrand J, 2001, PEDIATRICS, V108, P1155, DOI 10.1542/peds.108.5.1155
   Billstedt E, 2007, J CHILD PSYCHOL PSYC, V48, P1102, DOI 10.1111/j.1469-7610.2007.01774.x
   Borthwick-Duffy S. A., 1994, DESTRUCTIVE BEHAV DE, P3
   Cuccaro ML, 2007, AM J MED GENET B, V144B, P1022, DOI 10.1002/ajmg.b.30535
   Emerson E., 2001, CHALLENGING BEHAVIOR
   Epstein JN, 1998, J ABNORM CHILD PSYCH, V26, P109, DOI 10.1023/A:1022617821422
   Field A, 2005, DISCOVERING STATISTI, V2nd
   Fodstad JC, 2009, DEV NEUROREHABIL, V12, P152, DOI 10.1080/17518420902936748
   Goldman S, 2009, DEV MED CHILD NEUROL, V51, P30, DOI 10.1111/j.1469-8749.2008.03178.x
   Hattier MA, 2011, DEV NEUROREHABIL, V14, P221, DOI 10.3109/17518423.2011.573836
   Hill J, 2006, RES DEV DISABIL, V27, P517, DOI 10.1016/j.ridd.2005.07.001
   Holden B, 2006, RES DEV DISABIL, V27, P456, DOI 10.1016/j.ridd.2005.06.001
   Horner RH, 2002, J AUTISM DEV DISORD, V32, P423, DOI 10.1023/A:1020593922901
   HORNER RH, 1992, J ASSOC PERS SEVERE, V17, P154
   Horovitz M, 2011, DEV NEUROREHABIL, V14, P208, DOI 10.3109/17518423.2011.566596
   Horovitz M, 2010, DEV NEUROREHABIL, V13, P390, DOI 10.3109/17518423.2010.501431
   Jang JN, 2011, RES AUTISM SPECT DIS, V5, P1028, DOI 10.1016/j.rasd.2010.11.008
   Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
   Leech L., 2008, SPSS FOR INTRODUCTOR
   Levy A, 2011, RES AUTISM SPECT DIS, V5, P1271, DOI 10.1016/j.rasd.2011.01.023
   Macken J., 2009, J MENTAL HLTH RES IN, V2, P29
   Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
   Matson J, 2008, J INTELLECT DEV DIS, V33, P323, DOI 10.1080/13668250802492600
   Matson JL, 2008, J MENT HEALTH RES IN, V1, P34, DOI 10.1080/19315860701674498
   Matson J. L., 2006, AUTISM SPECTRUM DISO
   Wilkins J, 2007, INT REV RES MENT RET, V34, P321, DOI 10.1016/S0074-7750(07)34010-X
   Matson JL, 2008, RES AUTISM SPECT DIS, V2, P288, DOI 10.1016/j.rasd.2007.07.003
   Matson JL, 2008, J INTELLECT DEV DIS, V33, P36, DOI 10.1080/13668250701829837
   Matson JL, 2009, RES DEV DISABIL, V30, P572, DOI 10.1016/j.ridd.2008.08.007
   Matson JL, 2009, RES AUTISM SPECT DIS, V3, P207, DOI 10.1016/j.rasd.2008.05.006
   Matson JL, 2010, RES AUTISM SPECT DIS, V4, P626, DOI 10.1016/j.rasd.2009.12.006
   Matson JL, 2007, RES DEV DISABIL, V28, P567, DOI 10.1016/j.ridd.2006.08.001
   Matson JL, 1996, RES DEV DISABIL, V17, P135, DOI 10.1016/0891-4222(95)00044-5
   Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730
   Matson JL, 2010, J DEV PHYS DISABIL, V22, P331, DOI 10.1007/s10882-010-9188-y
   Matson JL, 2007, J DEV PHYS DISABIL, V19, P557, DOI 10.1007/s10882-007-9069-1
   McCarthy J, 2010, RES DEV DISABIL, V31, P362, DOI 10.1016/j.ridd.2009.10.009
   McTiernan A, 2011, RES AUTISM SPECT DIS, V5, P1215, DOI 10.1016/j.rasd.2011.01.009
   Murphy O, 2009, RES AUTISM SPECT DIS, V3, P474, DOI 10.1016/j.rasd.2008.09.008
   OLIVER C, 1987, J MENT DEFIC RES, V31, P147
   Reid R, 2001, J EMOT BEHAV DISORD, V9, P210, DOI 10.1177/106342660100900401
   Rojahn J., 2010, JOURNAL OF APPLIED R, V23, P179
   Sevin JA, 1995, J AUTISM DEV DISORD, V25, P561, DOI 10.1007/BF02178188
   Shattuck PT, 2007, J AUTISM DEV DISORD, V37, P1735, DOI 10.1007/s10803-006-0307-7
   Tsakanikos E, 2010, RES DEV DISABIL, V31, P410, DOI 10.1016/j.ridd.2009.10.007
   Tyrer F, 2006, J INTELL DISABIL RES, V50, P295, DOI 10.1111/j.1365-2788.2005.00774.x
   World Health Organization, 1992, INTERNATIONAL CLASSI
NR 52
TC 2
Z9 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1931-5864
EI 1931-5872
J9 J MENT HEALTH RES IN
JI J. Ment. Health Res. Intellect. Disabil.
PY 2013
VL 6
IS 1
BP 1
EP 13
DI 10.1080/19315864.2011.605989
PG 13
WC Education, Special; Psychiatry; Rehabilitation
SC Education & Educational Research; Psychiatry; Rehabilitation
GA AM2EX
UT WOS:000339663400001
ER

PT S
AU Fogassi, L
   Simone, L
AF Fogassi, Leonardo
   Simone, Luciano
BE Richardson, MJ
   Riley, MA
   Shockley, K
TI The Mirror System in Monkeys and Humans and its Possible Motor-Based
   Functions
SO PROGRESS IN MOTOR CONTROL: NEURAL, COMPUTATIONAL AND DYNAMIC APPROACHES
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Proceedings Paper
CT Official Scientific Meeting on Progress in Motor Control VIII of the
   International-Society-of-Motor-Control (ISMC)
CY JUL, 2011
CL Cincinnati, OH
SP Int Soc Motor Control
ID VENTRAL PREMOTOR CORTEX; AUTISM SPECTRUM DISORDERS; INFERIOR PARIETAL
   LOBULE; MACAQUE MONKEY; ACTION REPRESENTATION; TEMPORAL CORTEX; MAGNETIC
   STIMULATION; CORTICAL CONNECTIONS; ACTION ORGANIZATION; NEURON
   DYSFUNCTION
C1 [Fogassi, Leonardo; Simone, Luciano] Univ Parma, Dipartimento Neurosci, I-43100 Parma, Italy.
   [Fogassi, Leonardo; Simone, Luciano] Univ Parma, Ist Italiano Tecnol RTM, I-43100 Parma, Italy.
   [Fogassi, Leonardo] Univ Parma, Dipartimento Psicol, I-43100 Parma, Italy.
RP Fogassi, L (reprint author), Univ Parma, Dipartimento Neurosci, I-43100 Parma, Italy.
EM leonardo.fogassi@unipr.it
CR Arbib MA, 2005, BEHAV BRAIN SCI, V28, P105, DOI 10.1017/S0140525X05000038
   BARONCOHEN S, 1994, CAH PSYCHOL COGN, V13, P513
   Barraclough NE, 2006, PROG BRAIN RES, V154, P135, DOI 10.1016/S00079-6123(06)54007-5
   Bonini L, 2010, CEREB CORTEX, V20, P1372, DOI 10.1093/cercor/bhp200
   Bonini L, 2011, J NEUROSCI, V31, P5876, DOI 10.1523/JNEUROSCI.5186-10.2011
   Borra E, 2008, CEREB CORTEX, V18, P1094, DOI 10.1093/cercor/bhm146
   Brass M, 2007, CURR BIOL, V17, P2117, DOI 10.1016/j.cub.2007.11.057
   Buccino G, 2001, EUR J NEUROSCI, V13, P400, DOI 10.1046/j.1460-9568.2001.01385.x
   Buccino G, 2004, NEURON, V42, P323, DOI 10.1016/S0896-6273(04)00181-3
   Caggiano V, 2009, SCIENCE, V324, P403, DOI 10.1126/science.1166818
   Caggiano V, 2011, CURR BIOL, V21, P144, DOI 10.1016/j.cub.2010.12.022
   Calvo-Merino B, 2005, CEREB CORTEX, V15, P1243, DOI 10.1093/cercor/bhi007
   Cameirao MDS, 2011, RESTOR NEUROL NEUROS, V29, P287, DOI 10.3233/RNN-2011-0599
   Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
   Cattaneo L, 2009, J NEUROSCI, V29, P11134, DOI 10.1523/JNEUROSCI.2605-09.2009
   Chong TTJ, 2008, CURR BIOL, V18, P1576, DOI 10.1016/j.cub.2008.08.068
   Cisek P, 2005, NEURON, V45, P801, DOI 10.1016/j.neuron.2005.01.027
   Cochin S, 1999, EUR J NEUROSCI, V11, P1839, DOI 10.1046/j.1460-9568.1999.00598.x
   Corballis M. C., 2002, HAND MOUTH ORIGINS L
   Cross ES, 2006, NEUROIMAGE, V31, P1257, DOI 10.1016/j.neuroimage.2006.01.033
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   De Baene W, 2010, CEREB CORTEX, V20, P2145, DOI 10.1093/cercor/bhp277
   De Lange FP, 2008, CURR BIOL, V18, P454, DOI 10.1016/j.cub.2008.02.057
   DIPELLEGRINO G, 1992, EXP BRAIN RES, V91, P176
   Dinstein I, 2007, J NEUROPHYSIOL, V98, P1415, DOI 10.1152/jn.00238.2007
   Ertelt D, 2007, NEUROIMAGE, V36, pT164, DOI 10.1016/j.neuroimage.2007.03.043
   EVARTS EV, 1968, J NEUROPHYSIOL, V31, P14
   Fadiga L, 2002, EUR J NEUROSCI, V15, P399, DOI 10.1046/j.0953-816x.2001.01874.x
   FADIGA L, 1995, J NEUROPHYSIOL, V73, P2608
   Ferrari PF, 2003, EUR J NEUROSCI, V17, P1703, DOI 10.1046/j.1460-9568.2003.02601.x
   Ferrari PF, 2008, SOC NEUR ABSTR, V297, P13
   Ferrari PF, 2005, J COGNITIVE NEUROSCI, V17, P212, DOI 10.1162/0898929053124910
   Ferrari PF, 2006, PLOS BIOL, V4, P1501, DOI 10.1371/journal.pbio.0040302
   Filimon F, 2007, NEUROIMAGE, V37, P1315, DOI 10.1016/j.neuroimage.2007.06.008
   Fogassi L, 2011, WIRES COGN SCI, V2, P22, DOI 10.1002/wcs.89
   Fogassi L, 2005, SCIENCE, V308, P662, DOI 10.1126/science.1106138
   Fogassi L, 2007, CURR DIR PSYCHOL SCI, V16, P136, DOI 10.1111/j.1467-8721.2007.00491.x
   Frey SH, 2006, J NEUROSCI, V26, P13194, DOI 10.1523/JNEUROSCI.3914-06.2006
   Gallese V, 2002, ATTENTION PERFORM, V19, P334
   Gallese V, 1996, BRAIN, V119, P593, DOI 10.1093/brain/119.2.593
   Gangitano M, 2004, EUR J NEUROSCI, V20, P2193, DOI 10.1111/j.1460-9568.2004.03655.x
   Gazzola V, 2006, CURR BIOL, V16, P1824, DOI 10.1016/j.cub.2006.07.072
   Gazzola V, 2007, CURR BIOL, V17, P1235, DOI 10.1016/j.cub.2007.06.045
   Gazzola V, 2007, NEUROIMAGE, V35, P1674, DOI 10.1016/j.neuroimage.2007.02.003
   Gentilucci M, 2006, NEUROSCI BIOBEHAV R, V30, P949, DOI 10.1016/j.neubiorev.2006.02.004
   Gregoriou GG, 2006, J COMP NEUROL, V496, P422, DOI 10.1002/cne.20933
   Grezes J, 1998, COGNITIVE NEUROPSYCH, V15, P553, DOI 10.1080/026432998381023
   Grezes J, 2003, NEUROIMAGE, V18, P928, DOI 10.1016/S1053-8119(03)00042-9
   Grill-Spector K, 2006, TRENDS COGN SCI, V10, P14, DOI 10.1016/j.tics.2005.11.006
   GROSS CG, 1967, J NEUROPHYSIOL, V30, P833
   Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
   Hauk O, 2004, NEURON, V41, P301, DOI 10.1016/S0896-6273(03)00838-9
   Iacoboni M, 1999, SCIENCE, V286, P2526, DOI 10.1126/science.286.5449.2526
   Iacoboni M, 2005, PLOS BIOL, V3, P529, DOI 10.1371/journal.pbio.0030079
   Jeannerod M, 1988, NEURAL BEHAV ORG GOA
   JEANNEROD M, 1994, BEHAV BRAIN SCI, V17, P187
   Kaliukhovich DA, 2011, CEREB CORTEX, V21, P1547, DOI 10.1093/cercor/bhq207
   Kilner JM, 2009, J NEUROSCI, V29, P10153, DOI 10.1523/JNEUROSCI.2668-09.2009
   Kohler E, 2002, SCIENCE, V297, P846, DOI 10.1126/science.1070311
   Kohn A, 2007, J NEUROPHYSIOL, V97, P3155, DOI 10.1152/jn.00086.2007
   Koski L, 2002, CEREB CORTEX, V12, P847, DOI 10.1093/cercor/12.8.847
   Kraskov A, 2009, NEURON, V64, P922, DOI 10.1016/j.neuron.2009.12.010
   LIBERMAN AM, 1985, COGNITION, V21, P1, DOI 10.1016/0010-0277(85)90021-6
   Liepelt R, 2008, NEUROIMAGE, V43, P784, DOI 10.1016/j.neuroimage.2008.08.007
   Lingnau A, 2009, P NATL ACAD SCI USA, V106, P9925, DOI 10.1073/pnas.0902262106
   Lui F, 2008, SOC NEUROSCI, V3, P261, DOI 10.1080/17470910701458551
   McNeill D., 2000, LANGUAGE AND GESTURE
   Mukamel R., 2010, CURR BIOL, V20, P1
   Nelissen K, 2011, J NEUROSCI, V31, P3743, DOI 10.1523/JNEUROSCI.4803-10.2011
   Nelissen K, 2005, SCIENCE, V310, P332, DOI 10.1126/science.1115593
   Nishitani N, 2000, P NATL ACAD SCI USA, V97, P913, DOI 10.1073/pnas.97.2.913
   Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
   PANDYA DN, 1982, J COMP NEUROL, V204, P196, DOI 10.1002/cne.902040208
   Peeters R, 2009, J NEUROSCI, V29, P11523, DOI 10.1523/JNEUROSCI.2040-09.2009
   PERRETT DI, 1989, J EXP BIOL, V146, P87
   Petrides M, 2005, NATURE, V435, P1235, DOI 10.1038/nature03628
   Prather JF, 2008, NATURE, V451, P305, DOI 10.1038/nature06492
   Ramachandran VS, 2006, SCI AM, V295, P62
   Ringo JL, 1996, BEHAV BRAIN RES, V76, P191, DOI 10.1016/0166-4328(95)00197-2
   Rizzolatti G, 2009, COGNITIVE NEUROSCIEN, P625
   Rizzolatti G, 1997, CURR OPIN NEUROBIOL, V7, P562, DOI 10.1016/S0959-4388(97)80037-2
   Rizzolatti G, 1996, COGNITIVE BRAIN RES, V3, P131, DOI 10.1016/0926-6410(95)00038-0
   Rizzolatti G, 1996, EXP BRAIN RES, V111, P246
   Rizzolatti G, 2001, NEURON, V31, P889, DOI 10.1016/S0896-6273(01)00423-8
   Rizzolatti G, 1998, TRENDS NEUROSCI, V21, P188, DOI 10.1016/S0166-2236(98)01260-0
   Rizzolatti G, 2001, NAT REV NEUROSCI, V2, P661, DOI 10.1038/35090060
   Rochat MJ, 2010, EXP BRAIN RES, V204, P605, DOI 10.1007/s00221-010-2329-9
   Rosenbaum DA, 2007, HUM MOVEMENT SCI, V26, P525, DOI 10.1016/j.humov.2007.04.001
   Rozzi S, 2006, CEREB CORTEX, V16, P1389, DOI 10.1093/cercor/bhj076
   Rozzi S, 2008, EUR J NEUROSCI, V28, P1569, DOI 10.1111/j.1460-9568.2008.06395.x
   Shepherd SV, 2009, P NATL ACAD SCI USA, V106, P9489, DOI 10.1073/pnas.0900419106
   Shmuelof L, 2008, NAT NEUROSCI, V11, P1267, DOI 10.1038/nn.2196
   Tettamanti M, 2005, J COGNITIVE NEUROSCI, V17, P273, DOI 10.1162/0898929053124965
   Tkach D, 2007, J NEUROSCI, V27, P13241, DOI 10.1523/JNEUROSCI.2895-07.2007
   Umilta MA, 2008, P NATL ACAD SCI USA, V105, P2209, DOI 10.1073/pnas.0705985105
   Umilta MA, 2001, NEURON, V32, P91
   Visalberghi E., 1990, P247, DOI 10.1017/CBO9780511665486.011
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
   WOOLSEY C N, 1952, Res Publ Assoc Res Nerv Ment Dis, V30, P238
NR 99
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 0065-2598
BN 978-1-4614-5465-6; 978-1-4614-5464-9
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2013
VL 782
BP 87
EP 110
DI 10.1007/978-1-4614-5465-6_5
PG 24
WC Medicine, Research & Experimental; Clinical Neurology; Neurosciences
SC Research & Experimental Medicine; Neurosciences & Neurology
GA BA9DF
UT WOS:000339249300006
PM 23296482
ER

PT J
AU Roy, M
   Ohlmeier, MD
   Osterhagen, L
   Prox-Vagedes, V
   Dillo, W
AF Roy, Mandy
   Ohlmeier, Martin D.
   Osterhagen, Lasse
   Prox-Vagedes, Vanessa
   Dillo, Wolfgang
TI ASPERGER SYNDROME: A FREQUENT COMORBIDITY IN FIRST DIAGNOSED ADULT ADHD
   PATIENTS?
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE ADHD; Asperger syndrome; comorbidity; autism-spectrum quotient AQ;
   empathy quotient EQ
ID DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
   DISORDER; DOPAMINE TRANSPORTER; FUNCTIONING AUTISM; SPECTRUM DISORDER;
   MECHANISMS; BRAIN; METHYLPHENIDATE; ABNORMALITIES; ADOLESCENTS
AB Background: Because adult ADHD is often accompanied by psychiatric comorbidities, the diagnostic process should include a thorough investigation for comorbid disorders. Asperger-Syndrome is rarely reported in adult ADHD and commonly little attention is paid to this possible comorbidity.
   Subjects and methods: We investigated 53 adult ADHD-patients which visited our out patient clinic for first ADHD-diagnosis ( 17 females, 36 males; range of age: 18-56 years) for the frequency of a comorbid Asperger-Syndrome. Diagnosis of this autism-spectrum disorder was confirmed by applying the appropriate DSM-IV-criteria. Additionally we tested the power of the two screening-instruments "Autism-spectrum quotient" (AQ) and "Empathy quotient" (EQ) by Baron-Cohen for screening Asperger-Syndrome in adult ADHD.
   Results: Eight ADHD-patients were diagnosed with a comorbid Asperger-Syndrome (15.1%). The difference in AQ- and EQ-scores between pure ADHD-patients and comorbid patients was analysed, showing significantly higher scores in AQ and significant lower scores in EQ in comorbid patients.
   Conclusions: Results show that the frequency of Asperger- Syndrome seems to be substantially increased in adult ADHD (versus the prevalence of 0.06% in the general population), indicating that investigators of adult ADHD should also be attentive to autism-spectrum disorders. Especially the AQ seems to be a potential screening instrument for Asperger- Syndrome in adult ADHD-patients.
C1 [Roy, Mandy; Osterhagen, Lasse; Prox-Vagedes, Vanessa; Dillo, Wolfgang] Hannover Med Sch MHH, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany.
   [Ohlmeier, Martin D.] Ludwig Noll Hosp Klinikum Kassel, Dept Psychiat & Psychotherapy, Kassel, Germany.
RP Roy, M (reprint author), Hannover Med Sch MHH, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM Roy.Mandy@mh-hannover.de
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Attwood T, 2005, ASPERGER SYNDROM
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   BIEDERMAN J, 1992, ARCH GEN PSYCHIAT, V49, P728
   BIEDERMAN J, 1993, AM J PSYCHIAT, V150, P1792
   Brennan AR, 2008, ANN NY ACAD SCI, V1129, P236, DOI 10.1196/annals.1417.007
   Brieber S, 2007, J CHILD PSYCHOL PSYC, V48, P1251, DOI 10.1111/j.1469-7610.2007.01799.x
   Butler S F, 1995, Ann Clin Psychiatry, V7, P51, DOI 10.3109/10401239509149027
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Conners CK, 1999, CONNETS ADULT ADHD R
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   Dougherty DD, 1999, LANCET, V354, P2132, DOI 10.1016/S0140-6736(99)04030-1
   Dresel SHJ, 1999, J NUCL MED, V40, P660
   Dziobek I, 2011, NERVENARZT, V82, P564, DOI 10.1007/s00115-010-3240-0
   Ernst M, 1998, J NEUROSCI, V18, P5901
   Fangmeier T, 2011, NERVENARZT, V82, P628, DOI 10.1007/s00115-010-3121-6
   Faraone Stephen V, 2003, World Psychiatry, V2, P104
   Faraone SV, 1998, BIOL PSYCHIAT, V44, P951, DOI 10.1016/S0006-3223(98)00240-6
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279
   Gizer IR, 2009, HUM GENET, V126, P51, DOI 10.1007/s00439-009-0694-x
   Kahl KG, 2006, PRAXISHANDBUCH ADHS, P109
   Krause J, 2005, ADHS ERWACHSENENALTE
   Krause KH, 2003, NEUROSCI BIOBEHAV R, V27, P605, DOI 10.1016/j.neubiorev.2003.08.012
   Krause KH, 2000, NEUROSCI LETT, V285, P107, DOI 10.1016/S0304-3940(00)01040-5
   Lara C, 2009, BIOL PSYCHIAT, V65, P46, DOI 10.1016/j.biopsych.2008.10.005
   Lehrl S, 1993, MEHRFACHWAHL WORTSCH
   Masellis M, 2002, BEHAV BRAIN RES, V130, P85, DOI 10.1016/S0166-4328(01)00436-3
   Murphy DGM, 2002, ARCH GEN PSYCHIAT, V59, P885, DOI 10.1001/archpsyc.59.10.885
   Nieminen-von Wendt TS, 2004, NEUROREPORT, V15, P757
   Ohlmeier MD, 2008, ALCOHOL ALCOHOLISM, V43, P300, DOI 10.1093/alcalc/agn014
   Ohlmeier MD, 2007, PSYCHIAT PRAX, V34, P296, DOI 10.1055/s-2007-970972
   Remschmidt H., 2006, ASPERGER SYNDROM
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   Roy M, 2009, DTSCH ARZTEBL INT, V106, P59, DOI 10.3238/arztebl.2009.0059
   Roy M, 2009, J ATTEN DISORD, V12, P381, DOI 10.1177/1087054708320436
   Rubia K, 1999, AM J PSYCHIAT, V156, P891
   Sowell ER, 2003, LANCET, V362, P1699, DOI 10.1016/S0140-6736(03)14842-8
   Spencer TJ, 2007, BIOL PSYCHIAT, V62, P1059, DOI 10.1016/j.biopsych.2006.12.008
   Volkmar F. R., 2000, ASPERGER SYNDROME, P340
   WEINBERGER DR, 1993, J NEUROPSYCH CLIN N, V5, P241
   Williams DL, 2007, NEUROIMAG CLIN N AM, V17, P495, DOI 10.1016/j.nic.2007.07.007
   Williams JHG, 2006, NEUROPSYCHOLOGIA, V44, P610, DOI 10.1016/j.neuropsychologia.2005.06.010
NR 44
TC 1
Z9 1
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2013
VL 25
IS 2
BP 133
EP 141
PG 9
WC Psychiatry
SC Psychiatry
GA AK7TC
UT WOS:000338629600007
PM 23793277
ER

PT J
AU Politte, LC
   McDougle, CJ
AF Politte, Laura C.
   McDougle, Christopher J.
TI Phase II and III drugs for the treatment of fragile X syndrome
SO EXPERT OPINION ON ORPHAN DRUGS
LA English
DT Review
DE autism; FMRP; fragile X syndrome; GABA; GABA receptor agonists;
   glutamate; group 1 metabotropic glutamate receptors; intellectual
   disability; mGluR2/3 agonists; mGluR5 antagonists; NMDAR partial
   agonists; oxytocin; synaptic plasticity
ID MENTAL-RETARDATION PROTEIN; FOLIC-ACID TREATMENT; SITE PARTIAL AGONIST;
   SHORT-TERM-MEMORY; FMR1 KO MICE; MOUSE MODEL; DOUBLE-BLIND; METABOTROPIC
   GLUTAMATE; TREMOR/ATAXIA SYNDROME; MINOCYCLINE TREATMENT
AB Introduction: Fragile X syndrome (FXS), the most common inherited form of intellectual disability and autism, is caused by expansion of CGG trinucleotide repeats in FMR1 and marked reduction or absence of the gene product, FMRP. FMRP suppresses synaptic protein synthesis resulting from group 1 metabotropic glutamate receptor (mGluR) activation, a process critical to normal synaptic plasticity. FXS can be characterized as a disorder of synaptic plasticity with physical, cognitive and behavioral manifestations attributable to, at least in part, excessive mGluR activity and downstream effects.
   Areas covered: This paper reviews the 'mGluR theory' of FXS and the targeted drugs investigated in Phase II and III trials based on this theory of pathogenesis. A literature review was conducted using the PubMed database with search terms 'fragile X syndrome', 'mGluRs', 'pharmacotherapy' and specific drug-related terms. Other resources were identified by review of relevant reference lists and consultation with experts in the field.
   Expert opinion: While preclinical trials of targeted drugs in animal models of FXS have been encouraging, more studies are needed to determine clinical efficacy in humans. Challenges to clinical trial design and direction for future drug studies, including consideration of NMDA receptor partial agonists and mGluR2/3 agonists, are discussed.
C1 [Politte, Laura C.] Massachusetts Gen Hosp, Lexington, MA 02421 USA.
   [McDougle, Christopher J.] Lurie Ctr Autism, Lexington, MA 02421 USA.
RP Politte, LC (reprint author), Massachusetts Gen Hosp, Dept Psychiat, 1 Maguire Rd, Lexington, MA 02421 USA.
EM lpolitte@partners.org
CR Allingham-Hawkins Diane J., 1999, American Journal of Medical Genetics, V83, P322, DOI 10.1002/(SICI)1096-8628(19990402)83:4<322::AID-AJMG17>3.0.CO;2-B
   Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
   ARAI A, 1994, BRAIN RES, V638, P343, DOI 10.1016/0006-8993(94)90669-6
   Arai A, 1996, J PHARMACOL EXP THER, V278, P627
   ASHLEY CT, 1993, SCIENCE, V262, P563, DOI 10.1126/science.7692601
   Bailey DB, 2012, J DEV BEHAV PEDIATR, V33, P62, DOI 10.1097/DBP.0b013e318236c0e1
   Bear MF, 2005, GENES BRAIN BEHAV, V4, P393, DOI 10.1111/j.1601-183X.2005.00135.x
   Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009
   Bear MF, 2008, NEUROPSYCHOPHARMACOL, V33, P84, DOI 10.1038/sj.npp.1301610
   Berry-Kravis E, 2009, J MED GENET, V46, P266, DOI 10.1136/jmg.2008.063701
   Berry-Kravis E, 2011, J NEURODEV DISORD, V3, P193, DOI 10.1007/s11689-011-9074-7
   Berry-Kravis E, 2008, J DEV BEHAV PEDIATR, V29, P293, DOI 10.1097/DBP.0b013e31817dc447
   Berry-Kravis E, 2006, J CHILD ADOL PSYCHOP, V16, P525, DOI 10.1089/cap.2006.16.525
   Berry-Kravis EM, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004214
   Bilousova TV, 2009, J MED GENET, V46, P94, DOI 10.1136/jmg.2008.061796
   Bittel DC, 2007, GENET MED, V9, P464, DOI 10.1097/GIM.0b013e3180ca9a9a
   Brown MR, 2010, NAT NEUROSCI, V13, P819, DOI 10.1038/nn.2563
   Brown V, 2001, CELL, V107, P477, DOI 10.1016/S0092-8674(01)00568-2
   BROWN WT, 1986, ANN NY ACAD SCI, V477, P129, DOI 10.1111/j.1749-6632.1986.tb40329.x
   BROWN WT, 1986, AM J MED GENET, V23, P263, DOI 10.1002/ajmg.1320230120
   Brunberg JA, 2002, AM J NEURORADIOL, V23, P1757
   Choi CH, 2011, BRAIN RES, V1380, P106, DOI 10.1016/j.brainres.2010.11.032
   Comery TA, 1997, P NATL ACAD SCI USA, V94, P5401, DOI 10.1073/pnas.94.10.5401
   BAKKER CE, 1994, CELL, V78, P23
   Cordeiro L, 2011, J NEURODEV DISORD, V3, P57, DOI 10.1007/s11689-010-9067-y
   Darnell JC, 2001, CELL, V107, P489, DOI 10.1016/S0092-8674(01)00566-9
   deVries BBA, 1996, AM J HUM GENET, V58, P1025
   de Vrij FMS, 2008, NEUROBIOL DIS, V31, P127, DOI 10.1016/j.nbd.2008.04.002
   D'Hulst C, 2006, BRAIN RES, V1121, P238, DOI 10.1016/j.brainres.2006.08.115
   Dolen G, 2010, PHARMACOL THERAPEUT, V127, P78, DOI 10.1016/j.pharmthera.2010.02.008
   Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
   Dolen G, 2005, NEURON, V45, P642, DOI 10.1016/j.neuron.2005.02.021
   Erickson CA, 2010, J AUTISM DEV DISORD, V40, P1412, DOI 10.1007/s10803-010-0988-9
   Erickson CA, 2011, PSYCHOPHARMACOLOGY, V216, P85, DOI 10.1007/s00213-011-2194-7
   Erickson CA, 2011, BRAIN RES, V1380, P264, DOI 10.1016/j.brainres.2010.10.108
   Feng Y, 1997, MOL CELL, V1, P109, DOI 10.1016/S1097-2765(00)80012-X
   FISCH GS, 1988, AM J MED GENET, V30, P393, DOI 10.1002/ajmg.1320300139
   FROSTERISKENIUS U, 1986, AM J MED GENET, V23, P273, DOI 10.1002/ajmg.1320230121
   GILLBERG C, 1986, DEV MED CHILD NEUROL, V28, P624
   Goff DC, 2005, PSYCHOPHARMACOLOGY, V179, P144, DOI 10.1007/s00213-004-2032-2
   Goff DC, 2001, J CLIN PSYCHOPHARM, V21, P484, DOI 10.1097/00004714-200110000-00005
   Greco CM, 2002, BRAIN, V125, P1760, DOI 10.1093/brain/awf184
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
   Hagerman PJ, 2004, MENT RETARD DEV D R, V10, P25, DOI 10.1002/mrdd.20005
   Hagerman PJ, 2008, J MED GENET, V45, P498, DOI 10.1136/jmg.2008.059055
   HAGERMAN RJ, 1986, AM J MED GENET, V23, P241, DOI 10.1002/ajmg.1320230119
   HAGERMAN RJ, 1992, PEDIATRICS, V89, P395
   Hagerman RJ, 2001, NEUROLOGY, V57, P127
   Hagerman RJ, 2009, PEDIATRICS, V123, P378, DOI 10.1542/peds.2008-0317
   HAGERMAN RJ, 1988, AM J MED GENET, V30, P377, DOI 10.1002/ajmg.1320300138
   Hall SS, 2012, PSYCHONEUROENDOCRINO, V37, P509, DOI 10.1016/j.psyneuen.2011.07.020
   Hampson RE, 1998, J NEUROSCI, V18, P2740
   Hampson RE, 1998, J NEUROSCI, V18, P2748
   Hatton DD, 2006, AM J MED GENET A, V140A, P1804, DOI 10.1002/ajmg.a.31286
   Henderson C, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004218
   Heulens I, 2012, BEHAV BRAIN RES, V229, P244, DOI 10.1016/j.bbr.2012.01.031
   Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
   Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030
   Hopkins CR, 2011, ACS CHEM NEUROSCI, V2, P381, DOI 10.1021/cn200061g
   Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699
   Huber KM, 2000, SCIENCE, V288, P1254, DOI 10.1126/science.288.5469.1254
   Indiana University, 2011, AC YOUTH FRAG 10 SYN
   Jacquemont S, 2003, AM J HUM GENET, V72, P869, DOI 10.1086/374321
   Jacquemont S, 2006, J MED GENET, V43, P804, DOI 10.1136/jmg.2006.042374
   Jacquemont S, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001708
   Kesler SR, 2009, AM J MED GENET A, V149A, P403, DOI 10.1002/ajmg.a.32697
   Kinon BJ, 2011, J CLIN PSYCHOPHARM, V31, P349, DOI 10.1097/JCP.0b013e318218dcd5
   Kinon BJ, 2012, NEUROPHARMACOLOGY
   Kooy RF, 2003, TRENDS GENET, V19, P148
   LEJEUNE J, 1984, ANN GENET-PARIS, V27, P230
   Levenga J, 2011, NEUROBIOL DIS, V42, P311, DOI 10.1016/j.nbd.2011.01.022
   Li ZZ, 2001, NUCLEIC ACIDS RES, V29, P2276, DOI 10.1093/nar/29.11.2276
   Lindemann L, 2011, J PHARMACOL EXP THER, V339, P474, DOI 10.1124/jpet.111.185660
   Liu ZH, 2012, NEUROBIOL DIS, V45, P1145, DOI 10.1016/j.nbd.2011.12.037
   Liu Z-H, 2012, INT J NEUROPSYCHOPH, V14, P618
   Loesch DZ, 2003, AM J MED GENET A, V122A, P13, DOI 10.1002/ajmg.a.20214
   Loesch DZ, 2004, MENT RETARD DEV D R, V10, P31, DOI 10.1002/mrdd.20006
   Lu R, 2004, P NATL ACAD SCI USA, V101, P15201, DOI 10.1073/pnas.0404995101
   Lynch G, 2004, CURR OPIN PHARMACOL, V4, P4, DOI 10.1016/j.coph.2003.09.009
   Lynch G, 1997, EXP NEUROL, V145, P89, DOI 10.1006/exnr.1997.6447
   Martínez Raquel, 2005, Mol Diagn, V9, P157, DOI 10.2165/00066982-200509030-00006
   McBride SMJ, 2005, NEURON, V45, P753, DOI 10.1016/j.neuron.2005.01.038
   McDougle Christopher J, 2009, J AUTISM DEV DISORD, V39, P1629
   Michalon A, 2012, NEURON, V74, P49, DOI 10.1016/j.neuron.2012.03.009
   Min WW, 2009, NEUROPHARMACOLOGY, V56, P463, DOI 10.1016/j.neuropharm.2008.09.017
   Mines MA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009706
   Moskal JR, 2011, NEUROSCI BIOBEHAV R, V35, P1982, DOI 10.1016/j.neubiorev.2011.06.006
   Nakamoto M, 2007, P NATL ACAD SCI USA, V104, P15537, DOI 10.1073/pnas.0707484104
   Nathan Kline Institute for Psychiatric Research, 2012, D SER SCHIZ PRODR
   Naurex Inc., 2012, PHAS 2 DOUBL BLIND P
   NIH, 2012, SEARCH STX107 LIST R
   NIH, 2012, SEARCH RO4917523 LIS
   Nimchinsky EA, 2001, J NEUROSCI, V21, P5139
   Novartis, 2012, CLIN STUD ASS PHARM
   Novartis, 2012, LONG TERM SAF TOL ST
   Novartis, 2012, SAF EFF AFQ056 AD PA
   Novartis, 2012, LONG TERM SAF TOL EF
   Ortigas MC, 2010, J CLIN PSYCHOPHARM, V30, P642, DOI 10.1097/JCP.0b013e3181f1d10a
   Pacey LKK, 2011, J PHARMACOL EXP THER, V338, P897, DOI 10.1124/jpet.111.183327
   Pacey LKK, 2009, MOL PHARMACOL, V76, P18, DOI 10.1124/mol.109.056127
   Paribello C, 2010, BMC NEUROL, V10, DOI 10.1186/1471-2377-10-91
   Pascale E, 2003, J MED GENET, V40, DOI 10.1136/jmg.40.6.e76
   PECKNOLD JC, 1982, J CLIN PSYCHOPHARM, V2, P129
   Pesso R, 2000, PRENATAL DIAG, V20, P611, DOI 10.1002/1097-0223(200008)20:8<611::AID-PD881>3.0.CO;2-M
   Porter RHP, 2005, J PHARMACOL EXP THER, V229, P244
   Posey DJ, 2004, AM J PSYCHIAT, V161, P2115, DOI 10.1176/appi.ajp.161.11.2115
   Qin M, 2005, J NEUROSCI, V25, P5087, DOI 10.1523/JNEUROSCI.0093-05.2005
   Roberts JE, 2011, J NEURODEV DISORD, V3, P175, DOI 10.1007/s11689-011-9085-4
   Rotschafer SE, 2012, BRAIN RES, V1439, P7, DOI 10.1016/j.brainres.2011.12.041
   Rueda JR, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008476.pub2
   Sansone SM, 2012, J AUTISM DEV DISORD, V42, P1377, DOI 10.1007/s10803-011-1370-2
   Seaside Therapeutics, 2012, FIX DOS STUD EFF SAF
   Seaside Therapeutics, 2010, NEWS SEAS THER REP P
   Siller SS, 2011, DIS MODEL MECH, V4, P673, DOI 10.1242/dmm.008045
   Siller SS, 2012, NEURAL PLAST, V2012, P1
   SIOMI H, 1993, CELL, V74, P291, DOI 10.1016/0092-8674(93)90420-U
   Snyder EM, 2001, NAT NEUROSCI, V4, P1079, DOI 10.1038/nn746
   Spath MA, 2010, AM J MED GENET A, V152A, P387, DOI 10.1002/ajmg.a.33243
   Stanford University, 2012, RAND CONTR STUD DON
   STAUBLI U, 1994, P NATL ACAD SCI USA, V91, P777, DOI 10.1073/pnas.91.2.777
   STROM CM, 1992, AM J MED GENET, V44, P676, DOI 10.1002/ajmg.1320440529
   Suvrathan A, 2010, P NATL ACAD SCI USA, V107, P11591, DOI 10.1073/pnas.1002262107
   Tabolacci E, 2012, BMC MED GENET, V13, DOI 10.1186/1471-2350-13-13
   Tassone F, 2000, AM J HUM GENET, V66, P6, DOI 10.1086/302720
   Tassone F, 2000, AM J MED GENET, V91, P144, DOI 10.1002/(SICI)1096-8628(20000313)91:2<144::AID-AJMG14>3.0.CO;2-V
   Thomas AM, 2012, PSYCHOPHARMACOLOGY, V219, P47, DOI 10.1007/s00213-011-2375-4
   Torrioli MG, 1999, AM J MED GENET, V87, P366, DOI 10.1002/(SICI)1096-8628(19991203)87:4<366::AID-AJMG18>3.0.CO;2-F
   Torrioli MG, 2010, AM J MED GENET A, V152A, P1420, DOI 10.1002/ajmg.a.33484
   Torrioli MG, 2008, AM J MED GENET A, V146A, P803, DOI 10.1002/ajmg.a.32268
   Tranfaglia MR, 2011, DEV NEUROSCI-BASEL, V33, P337, DOI 10.1159/000329421
   Tsiouris JA, 2004, CNS DRUGS, V18, P687, DOI 10.2165/00023210-200418110-00001
   Turner G, 1996, AM J MED GENET, V64, P196, DOI 10.1002/(SICI)1096-8628(19960712)64:1<196::AID-AJMG35>3.0.CO;2-G
   University of California Davis, 2012, TRIAL MIN TREAT CHIL
   Utari A, 2010, AJIDD-AM J INTELLECT, V115, P433, DOI 10.1352/1944-7558-115.5.433
   Vanderklish PW, 2002, P NATL ACAD SCI USA, V99, P1639, DOI 10.1073/pnas.032681099
   Veloz MFV, 2012, GENES BRAIN BEHAV, V11, P325, DOI 10.1111/j.1601-183X.2011.00763.x
   VERHEIJ C, 1993, NATURE, V363, P722, DOI 10.1038/363722a0
   VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
   Wang HP, 2008, MOL BIOL CELL, V19, P105, DOI 10.1091/mbc.E07-06-0583
   Wei HE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036981
   Weiler IJ, 1997, P NATL ACAD SCI USA, V94, P5395, DOI 10.1073/pnas.94.10.5395
   WELLS TE, 1986, AM J MED GENET, V23, P291, DOI 10.1002/ajmg.1320230122
   Westmark CJ, 2010, INT J CLIN EXP PATHO, V3, P56
   Wirojanan J, 2009, J CLIN SLEEP MED, V5, P145
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
   Yan QJ, 2005, NEUROPHARMACOLOGY, V49, P1053, DOI 10.1016/j.neuropharm.2005.06.004
   Yuskaitis CJ, 2010, BIOCHEM PHARMACOL, V79, P632, DOI 10.1016/j.bcp.2009.09.023
   Zhang XL, 2008, NEUROPHARMACOLOGY, V55, P1238, DOI 10.1016/j.neuropharm.2008.08.018
   Zhang YQ, 2001, CELL, V107, P591, DOI 10.1016/S0092-8674(01)00589-X
NR 149
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 2167-8707
J9 EXPERT OPIN ORPHAN D
JI Exp. Opin. Orphan Drugs
PD JAN
PY 2013
VL 1
IS 1
BP 47
EP 65
DI 10.1517/21678707.2013.750240
PG 19
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AK1VM
UT WOS:000338205800005
ER

PT J
AU Broz, F
   Lehmann, H
   Mutlu, B
   Nakano, Y
AF Broz, Frank
   Lehmann, Hagen
   Mutlu, Bilge
   Nakano, Yukiko
TI Introduction to the Special Issue on Gaze in Human-Robot Communication
SO INTERACTION STUDIES
LA English
DT Editorial Material
ID UNIQUE MORPHOLOGY; ASPERGER-SYNDROME; NORMAL ADULTS; HUMAN EYE; AUTISM;
   HYPOTHESIS; INFANTS
C1 [Broz, Frank] Univ Plymouth, Sch Comp & Math, Plymouth PL4 8AA, Devon, England.
   [Lehmann, Hagen] Univ Hertfordshire, Sch Comp Sci, Hatfield AL10 9AB, Herts, England.
   [Mutlu, Bilge] Univ Wisconsin, Dept Comp Sci, Madison, WI 53706 USA.
   [Nakano, Yukiko] Seikei Univ, Dept Comp & Informat Sci, Tokyo, Japan.
RP Broz, F (reprint author), Univ Plymouth, Sch Comp & Math, Plymouth PL4 8AA, Devon, England.
EM frank.broz@plymouth.ac.uk; h.lehmann@herts.ac.uk; bilge@cs.wisc.edu;
   y.nakano@st.seikei.ac.jp
CR Argyle M., 1988, BODILY COMMUNICATION
   BARONCOHEN S, 1995, BRIT J DEV PSYCHOL, V13, P379
   BaronCohen S, 1997, VIS COGN, V4, P311, DOI 10.1080/713756761
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Broz F., 2012, P IEEE INT S ROB HUM
   Cassell J., 2000, EMBODIED CONVERSATIO
   Farroni T, 2003, J EXP CHILD PSYCHOL, V85, P199, DOI 10.1016/S0022-0965(03)00022-5
   KLEINKE CL, 1986, PSYCHOL BULL, V100, P78, DOI 10.1037//0033-2909.100.1.78
   Kobayashi H, 2001, J HUM EVOL, V40, P419, DOI 10.1006/jhev.2001.0468
   Kobayashi H, 1997, NATURE, V387, P767, DOI 10.1038/42842
   Meltzoff A. N, 2007, GAZE FOLLOWING ITS D, P217
   Mutlu B., 2009, P 4 ACM IEEE INT C H, P61, DOI DOI 10.1145/1514095.1514109
   Nakano Yukiko I., 2003, P 41 ANN M ASS COMP, V1, P553, DOI 10.3115/1075096.1075166
   Novick DG, 1996, ICSLP 96 - FOURTH INTERNATIONAL CONFERENCE ON SPOKEN LANGUAGE PROCESSING, PROCEEDINGS, VOLS 1-4, P1888
   Tomasello M, 2007, J HUM EVOL, V52, P314, DOI 10.1016/j.jhevo1.2006.10.001
   Trevarthen C, 2001, J CHILD PSYCHOL PSYC, V42, P3, DOI 10.1017/S0021963001006552
   Yu C., 2012, ACM T INTERACT INTEL, V1, P13
NR 17
TC 0
Z9 0
PU JOHN BENJAMINS PUBLISHING COMPANY
PI AMSTERDAM
PA PO BOX 36224, 1020 ME AMSTERDAM, NETHERLANDS
SN 1572-0373
EI 1572-0381
J9 INTERACT STUD
JI Interact. Stud.
PY 2013
VL 14
IS 3
SI SI
BP VII
EP XV
DI 10.1075/is.14.3.001int
PG 9
WC Communication; Linguistics
SC Communication; Linguistics
GA AK3UY
UT WOS:000338351400001
ER

PT J
AU Cassel, RS
   Saint-Georges, C
   Mahdhaoui, A
   Chetouani, M
   Laznik, MC
   Muratori, F
   Adrien, JL
   Cohen, D
AF Cassel, Raquel S.
   Saint-Georges, Catherine
   Mahdhaoui, Ammar
   Chetouani, Mohamed
   Laznik, Marie Christine
   Muratori, Filippo
   Adrien, Jean-Louis
   Cohen, David
TI Course of maternal prosodic incitation (motherese) during early
   development in autism
SO INTERACTION STUDIES
LA English
DT Article
DE Autism; motherese; early interaction; computational methods
ID EARLY ADOLESCENT OUTCOMES; NON-DEPRIVED ADOPTEES; 4-MONTH-OLD INFANTS;
   VOCAL BEHAVIOR; FATHER-INFANT; 1ST YEAR; SPEECH; LIFE; RECOGNITION;
   LANGUAGE
AB We examined the course of caregiver (CG) motherese and the course of the infant's response based on home movies from two single cases: a boy with typical development (TD) and a boy with autistic development (AD). We first blindly assessed infant CG interaction using the Observer computer-based coding procedure, then analyzed speech CG production using a computerized algorithm. Finally we fused the two procedures and filtered for co-occurrence. In this exploratory study we found that the course of CG parentese differed based on gender (father vs. mother) and child status (TD vs. AD). The course of an infant's response to CG vocalization differed according to the type of speech (motherese vs. other speech) and child status (TD vs. AD). Mothers spent more time interacting with infants, and fathers appeared to interact with their child preferentially between 12 and 18 months in the TD boy, but not in the AD boy. The TD boy responded equally well to motherese compared to other speech after 1 year of age. For the AD boy, the responses to both types of speech were lower than in the boy with TD and decreased from the second to the third semester.
C1 [Cassel, Raquel S.; Saint-Georges, Catherine; Cohen, David] Univ Paris 06, Grp Hosp Pitie Salpetriere, AP HP, Dept Child & Adolescent Psychiat, Paris, France.
   [Saint-Georges, Catherine; Mahdhaoui, Ammar; Chetouani, Mohamed; Cohen, David] Univ Paris 06, CNRS FRE 2507, Inst Syst Intelligents & Robot, Paris, France.
   [Laznik, Marie Christine] Assoc Sante Mentale 13eme, Dept Child & Adolescent Psychiat, Paris, France.
   [Muratori, Filippo] Univ Pisa, Sci Inst Stella Maris, I-56100 Pisa, Italy.
   [Cassel, Raquel S.; Adrien, Jean-Louis] Univ Paris 05, Inst Psychol, LPPS, EA 4057, Paris, France.
RP Cassel, RS (reprint author), Univ Paris 06, Grp Hosp Pitie Salpetriere, AP HP, Dept Child & Adolescent Psychiat, Paris, France.
EM david.cohen@psl.aphp.fr
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
   ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
   BLOOM K, 1975, J EXP CHILD PSYCHOL, V20, P51, DOI 10.1016/0022-0965(75)90025-9
   Braarud HC, 2008, SOC DEV, V17, P1074, DOI 10.1111/j.1467-9507.2007.00455.x
   CARREY NJ, 1995, J AM ACAD CHILD PSY, V34, P1655, DOI 10.1097/00004583-199512000-00016
   CLARKESTEWART KA, 1978, CHILD DEV, V49, P466, DOI 10.1111/j.1467-8624.1978.tb02337.x
   Croft C, 2007, J CHILD PSYCHOL PSYC, V48, P31, DOI 10.1111/j.1469-7610.2006.01689.x
   Crown CL, 2002, J PSYCHOLINGUIST RES, V31, P1, DOI 10.1023/A:1014301303616
   Feldman R, 2003, INFANT MENT HEALTH J, V24, P1, DOI 10.1002/imhj.10041
   FERNALD A, 1989, J CHILD LANG, V16, P477
   Fernald A., 1991, ANN CHILD DEV, V8, P43
   FERNALD A, 1985, INFANT BEHAV DEV, V8, P181, DOI 10.1016/S0163-6383(85)80005-9
   FERNALD A, 1987, INFANT BEHAV DEV, V10, P279, DOI 10.1016/0163-6383(87)90017-8
   FIELD T, 1978, DEV PSYCHOL, V14, P183
   Goldstein MH, 2003, P NATL ACAD SCI USA, V100, P8030, DOI 10.1073/pnas.1332441100
   Kaplan PS, 2004, DEV PSYCHOL, V40, P140, DOI 10.1037/0012-1649.40.2.140
   Kuhl PK, 2007, DEVELOPMENTAL SCI, V10, P110, DOI 10.1111/j.1467-7687.2007.00572.x
   LAMB ME, 1977, CHILD DEV, V48, P167, DOI 10.1111/j.1467-8624.1977.tb04257.x
   LAMB ME, 1977, DEV PSYCHOL, V13, P637, DOI 10.1037//0012-1649.13.6.637
   Laznik M. C., 2005, COMMENCEMENT TAIT VO, P171
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Maestro S, 2005, PSYCHOPATHOLOGY, V38, P26, DOI 10.1159/000083967
   Mahdhaoui A, 2011, INT J METH PSYCH RES, V20, pE6, DOI 10.1002/mpr.332
   Muratori F, 2011, RES AUTISM SPECT DIS, V5, P408, DOI 10.1016/j.rasd.2010.06.003
   Muratori F, 2011, EPIDEMIOL PSYCH SCI, V20, P329, DOI 10.1017/S204579601100045X
   Niwano K., 2003, JPN J SPEC ED, V40, P663
   PAPOUSEK M, 1991, INFANT BEHAV DEV, V14, P415, DOI 10.1016/0163-6383(91)90031-M
   Parke R. D., 1980, FATHER INFANT RELATI, P44
   REBELSKY F, 1971, CHILD DEV, V42, P63, DOI 10.1111/j.1467-8624.1971.tb03618.x
   Rutter M., 2003, ADI R AUTISM DIAGNOS, DOI [10.1111/j.1469-7610.2006.01688.x, DOI 10.1111/J.1469-7610.2006.01688.X]
   Rutter M, 2007, J CHILD PSYCHOL PSYC, V48, P1200, DOI 10.1111/j.1469-7610.2007.01792.x
   Saint-Georges C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078103
   Saint-Georges C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022393
   Saint-Georges C, 2010, RES AUTISM SPECT DIS, V4, P355, DOI 10.1016/j.rasd.2009.10.017
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Schuller B, 2007, INTERSPEECH 2007: 8TH ANNUAL CONFERENCE OF THE INTERNATIONAL SPEECH COMMUNICATION ASSOCIATION, VOLS 1-4, P881
   Shute B., 1999, ED PSYCHOL, V19, P221, DOI 10.1080/0144341990190208
   STONE WL, 1994, ARCH PEDIAT ADOL MED, V148, P174
   Werner E, 2000, J AUTISM DEV DISORD, V30, P157, DOI 10.1023/A:1005463707029
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 40
TC 0
Z9 0
PU JOHN BENJAMINS PUBLISHING COMPANY
PI AMSTERDAM
PA PO BOX 36224, 1020 ME AMSTERDAM, NETHERLANDS
SN 1572-0373
EI 1572-0381
J9 INTERACT STUD
JI Interact. Stud.
PY 2013
VL 14
IS 3
SI SI
BP 480
EP 495
DI 10.1075/is.14.3.08cas
PG 16
WC Communication; Linguistics
SC Communication; Linguistics
GA AK3UY
UT WOS:000338351400009
ER

PT J
AU Buse, M
   Giuffre, M
   Martines, M
   Piro, E
   Piccione, M
   Corsello, G
AF Buse, Martina
   Giuffre, Mario
   Martines, Manuela
   Piro, Ettore
   Piccione, Maria
   Corsello, Giovanni
TI 16P11.2 MICRODELETION/MICRODUPLICATION SYNDROME: FURTHER
   CHARACTERIZATION OF A CRITICAL REGION FOR NEUROPSYCHIATRIC DEVELOPMENT
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE 16p11.2; a-CGH; language delay; dysmorphic features
ID COMPARATIVE-GENOMIC-HYBRIDIZATION; STRUCTURAL VARIATION; CANDIDATE
   GENES; ARRAY-CGH; AUTISM; DELETION; MICRODUPLICATION; MICRODELETION;
   RETARDATION; ASSOCIATION
AB Several studies have shown the importance of Copy Number Variations (CNVs) in the etiology of autism spectrum disorders (ASDs). In particular, a CNV of about 550 Kb in 16p11.2 has recently been described in up to 1% of autistic patients. Deletions and mutual duplications of this region have also been associated with neurocognitive abnormalities, impairment in social interaction, language delay, congenital anomalies, minor dysmorphisms, respectively micro- and macrocephaly.
   We report 4 patients with 16p11.2 microdeletion and one patient with 16p11.2 microduplication. All patients have language delay and dysmorphic features, even if there is no common phenotype.
   Even in our experience, the identification by array-CGH of cryptic chromosomal abnormalities and de novo pathological CNVs helped us to make a more accurate genotype-phenotype correlation and to establish individualized diagnostic and therapeutic strategies.
C1 [Buse, Martina; Giuffre, Mario; Piro, Ettore; Piccione, Maria; Corsello, Giovanni] Univ Palermo, Dipartimento Sci Promoz Salute & Materno Infantil, I-90133 Palermo, Italy.
   [Martines, Manuela] CRR Malattie Rare AOOR Villa Sofia Cervello Paler, Palermo, Italy.
RP Buse, M (reprint author), Via A Giordano 3, I-90127 Palermo, Italy.
CR Cipolla D, 2011, J MATERN-FETAL NEO M, V24, P23, DOI 10.3109/14767058.2011.607567
   Corsello G, 2012, J MATERN-FETAL NEO M, V25, P25, DOI 10.3109/14767058.2012.664943
   David Sabrina, 2013, Front Biosci (Elite Ed), V5, P768
   Ghebranious N, 2007, AM J MED GENET A, V143A, P1462, DOI 10.1002/ajmg.a.31837
   Ghirri P, 2009, ITAL J PEDIATR, V35, DOI 10.1186/1824-7288-35-18
   Giuffre M, 2011, AREA PEDIAT, V12, P25
   Giuffrè Mario, 2012, BMC Pediatr, V12, P64, DOI 10.1186/1471-2431-12-64
   Giuffre M, 2012, J MATERN-FETAL NEO M, V25, P6, DOI 10.3109/14767058.2012.712350
   Gribble SM, 2005, J MED GENET, V42, P8, DOI 10.1136/jmg.2004.024141
   Isidor B, 2013, EUR J HUM GENET, V21, P784, DOI 10.1038/ejhg.2012.252
   Konyukh M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017289
   Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376
   Kumar RA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004582
   Lo Iacono M, 2011, OPEN TISSUE ENG REGE, V4, P72
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Piccione M, 2009, AM J MED GENET A, V149A, P1837, DOI 10.1002/ajmg.a.32952
   Piccione M, 2012, AM J MED GENET A, V158A, P1427, DOI 10.1002/ajmg.a.35334
   Piccione M, 2012, MINERVA PEDIATR, V64, P59
   Piccione M, 2012, EUR J MED GENET, V55, P238, DOI 10.1016/j.ejmg.2012.01.014
   Piccione M, 2011, AM J MED GENET A, V155A, P3054, DOI 10.1002/ajmg.a.34275
   Piccione M, 2012, AM J MED GENET A, V158A, P150, DOI 10.1002/ajmg.a.34308
   Schierz IAM, 2011, AM J PERINAT, V28, P177, DOI 10.1055/s-0030-1265829
   Schierz IAM, 2014, AM J PERINAT, V31, P49, DOI 10.1055/s-0033-1334447
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Shaw-Smith C, 2004, J MED GENET, V41, P241, DOI 10.1136/jmg.2003.017731
   Stankiewicz P, 2010, ANNU REV MED, V61, P437, DOI 10.1146/annurev-med-100708-204735
   Striano P, 2012, ARCH NEUROL-CHICAGO, V69, P322, DOI 10.1001/archneurol.2011.1999
   Viaggi CD, 2012, J APPL GENET, V3, P285
   Vissers LE, 2003, ARRAY BASED COMP GEN
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
NR 30
TC 3
Z9 3
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2013
VL 29
IS 2
BP 241
EP 246
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AJ8BI
UT WOS:000337927100018
ER

PT J
AU Piro, E
   Buse, M
   Sciarrabone, GM
   Antona, V
   Martines, M
   Ballacchino, A
   Piccione, M
   Corsello, G
AF Piro, Ettore
   Buse, Martina
   Sciarrabone, Giustina Maria
   Antona, Vincenzo
   Martines, Manuela
   Ballacchino, Antonella
   Piccione, Maria
   Corsello, Giovanni
TI COPY NUMBER VARIATIONS IN THE ETIOLOGY OF AUTISM SPECTRUM DISORDERS
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Autism spectrum disorders; a-CGH; genomic variants
ID COMPARATIVE-GENOMIC-HYBRIDIZATION; SENSORINEURAL HEARING-LOSS;
   ARRAY-CGH; CONGENITAL-MALFORMATIONS; DELETION; PREVALENCE; INFANTS;
   16P11.2; GENE; MICRODUPLICATION
AB Autism Spectrum Disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders, characterized by qualitative impairment in social interaction and communication and restricted, repetitive and stereotyped patterns of behavior, interests and activities. They have a multifactorial etiology, but today different studies are showing the central role of genetics. Different genetic alterations were detected: chromosomal abnormalities, mutations, trinucleotide repeats and copy number variations (CNVs).
   Several studies identified many CNVs associated with ASDs and possible candidate genes, whose loss or gain could have a key role in the etiopathogenesis of these disorders. In particular, they seem to be involved in neurogenesis, neuronal migration, differentiation and degeneration.
   We want emphasize that the final phenotype is variable, related not only to the genetic background but also to environmental factors.
C1 [Piro, Ettore; Buse, Martina; Sciarrabone, Giustina Maria; Antona, Vincenzo; Piccione, Maria; Corsello, Giovanni] Univ Palermo, Dipartimento Sci Promoz Salute & Materno Infantil, I-90133 Palermo, Italy.
   [Martines, Manuela] CRR Malattie Rare AOOR Villa Sofia Cervello Paler, Palermo, Italy.
   [Ballacchino, Antonella] Univ Palermo, Dipartimento Biopatol & Biotecnol Med & Forenzi D, Sez Audiol, I-90133 Palermo, Italy.
RP Piccione, M (reprint author), Via A Giordano 3, I-90127 Palermo, Italy.
CR Bijlsma EK, 2009, EUR J MED GENET, V52, P77, DOI 10.1016/j.ejmg.2009.03.006
   Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
   Cipolla D, 2011, J MATERN-FETAL NEO M, V24, P23, DOI 10.3109/14767058.2011.607567
   Corsello G, 2012, J MATERN-FETAL NEO M, V25, P25, DOI 10.3109/14767058.2012.664943
   David Sabrina, 2013, Front Biosci (Elite Ed), V5, P768
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
   Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x
   Ghirri P, 2009, ITAL J PEDIATR, V35, DOI 10.1186/1824-7288-35-18
   Giuffre M, 2011, AREA PEDIAT, V12, P25
   Giuffrè Mario, 2012, BMC Pediatr, V12, P64, DOI 10.1186/1471-2431-12-64
   Giuffrè Mario, 2013, Antimicrob Resist Infect Control, V2, P8, DOI 10.1186/2047-2994-2-8
   Giuffre M, 2012, J MATERN-FETAL NEO M, V25, P6, DOI 10.3109/14767058.2012.712350
   Guerra DJ, 2011, AUTISM RES TREATMENT, V2011, DOI [10.1155/2011/398636, DOI 10.1155/2011/398636]
   Hanson E, 2010, J DEV BEHAV PEDIATR, V31, P649, DOI 10.1097/DBP.0b013e3181ea50ed
   Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
   Lo Iacono M, 2011, OPEN TISSUE ENG REGE, V4, P72
   Lopez-Atalaya JP, 2012, J MED GENET, V49, P66, DOI 10.1136/jmedgenet-2011-100354
   lsidor B, 2012, EUR J HUM GENET, DOI [10.1038/ejhg.2012.252., DOI 10.1038/EJHG.2012.252]
   Mammina C, 2007, AM J INFECT CONTROL, V35, P222, DOI 10.1016/j.ajic.2006.04.210
   Martines F, 2012, INT J PEDIATR OTORHI, V76, P1285, DOI 10.1016/j.ijporl.2012.05.020
   Martines F, 2007, INT J PEDIATR OTORHI, V71, P107, DOI 10.1016/j.ijporl.2006.09.011
   Martines F, 2013, INT J PEDIATR OTORHI, V77, P707, DOI 10.1016/j.ijporl.2013.01.023
   Martines F, 2013, INT J PEDIATR OTORHI, V77, P513, DOI 10.1016/j.ijporl.2012.12.023
   Martines F, 2012, INT J PEDIATR OTORHI, V76, P423, DOI 10.1016/j.ijporl.2011.12.024
   Mulhe R, 2004, PEDIATRICS, V113, pe427
   Piccione M, 2009, AM J MED GENET A, V149A, P1837, DOI 10.1002/ajmg.a.32952
   Piccione M, 2012, AM J MED GENET A, V158A, P1427, DOI 10.1002/ajmg.a.35334
   Piccione M, 2012, MINERVA PEDIATR, V64, P59
   Piccione M, 2012, EUR J MED GENET, V55, P238, DOI 10.1016/j.ejmg.2012.01.014
   Piccione M, 2011, AM J MED GENET A, V155A, P3054, DOI 10.1002/ajmg.a.34275
   Piccione M, 2012, AM J MED GENET A, V158A, P150, DOI 10.1002/ajmg.a.34308
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Puccio G, 2013, ITAL J PEDIATR, V39, DOI 10.1186/1824-7288-39-23
   Salvago P, 2013, EUR ARCH OTO-RHINO-L, V270, P3049, DOI 10.1007/s00405-013-2379-2
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Schierz IAM, 2011, AM J PERINAT, V28, P177, DOI 10.1055/s-0030-1265829
   Schierz IAM, 2014, AM J PERINAT, V31, P49, DOI 10.1055/s-0033-1334447
   Shaw-Smith C, 2004, J MED GENET, V41, P241, DOI 10.1136/jmg.2003.017731
   Striano P, 2012, ARCH NEUROL-CHICAGO, V69, P322, DOI 10.1001/archneurol.2011.1999
   Varga EA, 2009, GENET MED, V11, P111, DOI 10.1097/GIM.0b013e31818fd762
   Viaggi CD, 2012, J APPL GENET, V53, P285, DOI 10.1007/s13353-012-0097-x
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
NR 43
TC 2
Z9 2
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2013
VL 29
IS 2
BP 337
EP 342
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA AJ8BI
UT WOS:000337927100037
ER

PT J
AU Shaffer, C
AF Shaffer, Cheryl
TI Parenting Stress in Mothers of Preschool-Age Children Recently Diagnosed
   With Autism Spectrum Disorder: A National Quantitative Study and
   Implications for Nurses
SO JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1078-3903
EI 1532-5725
J9 J AM PSYCHIAT NURSES
JI J. Am. Psych. Nurses Assoc.
PD JAN-FEB
PY 2013
VL 19
IS 1
BP 25
EP 25
PG 1
WC Nursing; Psychiatry
SC Nursing; Psychiatry
GA AJ2QX
UT WOS:000337505400049
ER

PT S
AU Vasquez, K
   Kuizon, S
   Junaid, M
   El Idrissi, A
AF Vasquez, Kizzy
   Kuizon, Salomon
   Junaid, Mohammed
   El Idrissi, Abdeslem
BE ElIdrissi, A
   LAmoreaux, WJ
TI The Effect of Folic Acid on GABA(A)-B 1 Receptor Subunit
SO TAURINE 8, VOL 1: THE NERVOUS SYSTEM, IMMUNE SYSTEM, DIABETES AND THE
   CARDIOVASCULAR SYSTEM
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Proceedings Paper
CT 18th International Taurine Meeting
CY APR 07-13, 2012
CL Marrakesh, MOROCCO
SP Taisho Pharmaceut Co Ltd
ID SERVICES TASK-FORCE; NEURAL-TUBE DEFECTS; SUPPLEMENTATION; PREVENTION
AB Autism contains a spectrum of behavioral and cognitive disturbances of childhood development that is manifested by deficits in social interaction, impaired communication, repetitive behavior, and/or restricted interest. Much research has been dedicated to finding the genes that are responsible for autism, but less than 10% of the cases can be attributed to one gene. Autism prevalence has increased in the last decade and there may be environmental components that are leading to this increase. There are reports of disruption of epigenetic mechanisms controlling the regulation of gene expression as probable cause for autism. Folic acid (FA) is prescribed to women during pregnancy, and can cause epigenetic changes. GABAergic pathway is involved in inhibitory neurotransmission in the central nervous system and plays a crucial role during early embryonic development. Autism may entail defect or deregulation of the GABAergic receptor pathway in the brain. Gamma-aminobutyric acid (type A) beta 1 receptor (GABRB1) disruption has been implicated in autism. In the present study, we investigated GABRB1 expression in response to FA supplementation in neuronal cells. Western blot analysis showed GABRB1 protein levels increased in the FA-treated cells in a concentration-dependent manner. FA-dependent increased expression of GABRB1 was further confirmed at the mRNA level using quantitative RT-PCR. These results suggest that epigenetic control of gene expression may affect the expression of GABRB1 and disrupt inhibitory synaptic transmission during embryonic development.
C1 [Vasquez, Kizzy; El Idrissi, Abdeslem] CUNY Coll Staten Isl, Dept Biol, Staten Isl, NY 10314 USA.
   [Vasquez, Kizzy; El Idrissi, Abdeslem] CUNY, Grad Sch, New York, NY USA.
   [Vasquez, Kizzy; Kuizon, Salomon; Junaid, Mohammed] New York State Inst Basic Res, Dept Struct Neurobiol, Staten Isl, NY 10314 USA.
RP Vasquez, K (reprint author), CUNY Coll Staten Isl, Dept Biol, Staten Isl, NY 10314 USA.
EM kizzyv@gmail.com
FU New York State Office for People with Developmental Disabilities; City
   University of New York; College of Staten Island; Louis Stokes Alliance
   for Minority Participation a division of National Science Foundation
   (NSF)
FX This study is supported by funds from the New York State Office for
   People with Developmental Disabilities, The City University of New York,
   The College of Staten Island, and Louis Stokes Alliance for Minority
   Participation a division of National Science Foundation (NSF). Financial
   assistance to Kizzy Vasquez is gratefully acknowledged.
CR Beard CM, 2011, MED HYPOTHESES, V77, P15, DOI 10.1016/j.mehy.2011.03.013
   Bekkers MBM, 2012, EUR RESPIR J, V39, P1468, DOI 10.1183/09031936.00094511
   Calonge N, 2009, ANN INTERN MED, V150, P626
   Fatemi SH, 2010, J AUTISM DEV DISORD, V40, P743, DOI 10.1007/s10803-009-0924-z
   Huang ZJ, 2007, NAT REV NEUROSCI, V8, P673, DOI 10.1038/nrn2188
   Junaid MA, 2011, BIOCHEM BIOPH RES CO, V412, P688, DOI 10.1016/j.bbrc.2011.08.027
   Kuizon S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011929
   McLennan Y, 2011, CURR GENOMICS, V12, P216, DOI 10.2174/138920211795677886
   MMWR, 1992, MMWR-MORBID MORTAL W, V41, P1
   Olsen RW, 2009, NEUROPHARMACOLOGY, V56, P141, DOI 10.1016/j.neuropharm.2008.07.045
   Pfeiffer CM, 2004, CLIN CHEM, V50, P423, DOI 10.1373/clinchem.2003.026955
   Wolff T, 2009, ANN INTERN MED, V150, P632
   Zhang AY, 2009, BIOCHEM BIOPH RES CO, V379, P920, DOI 10.1016/j.bbrc.2008.12.172
NR 13
TC 2
Z9 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 0065-2598
BN 978-1-4614-6130-2; 978-1-4614-6129-6
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2013
VL 775
BP 101
EP 109
DI 10.1007/978-1-4614-6130-2_8
PG 9
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA BA7JC
UT WOS:000337591500008
PM 23392927
ER

PT J
AU De Araujo, G
   Lerner, R
   Hoffmann, C
   Laznik, MC
AF De Araujo, Gabriela
   Lerner, Rogerio
   Hoffmann, Christian
   Laznik, Marie-Christine
TI A STUDY OF THE DEVELOPMENT OF THE BROTHERS AND SISTERS OF AUTISTIC
   CHILDREN
SO PSYCHIATRIE DE L ENFANT
LA French
DT Article
DE Sibling group; Autism; Subject; Development; Psychoanalysis
ID SIBLINGS; COMMUNICATION; BEHAVIORS
AB This article presents the first conclusions of research whose aim is to study the developmental process of brothers and sisters of autistic children and to analyse the difficulties involved. Our basis is the psychoanalytical hypothesis that a subject constructs himself by means of the instinctual relationship he establishes with the Other. When this instinctual relationship with the Other is not set into place, we can observe a difficulty in the constitution of the subject. Autism is the consequence of the non-installation of this link due to several factors. We suppose that among the siblings of an autistic child, there will be obstacles to the installation of this link. To verify this hypothesis, we use clinical indicators of risk for infantile development (IRDI) and the signs of the Research program on Autism (PREAUT) in order to analyse six clinical cases of brothers and sisters of autistic children.
C1 [De Araujo, Gabriela; Hoffmann, Christian] Univ Paris 07, Sorbonne Paris Cite, F-75221 Paris 05, France.
   [De Araujo, Gabriela; Lerner, Rogerio] Univ Sao Paulo, BR-05508 Sao Paulo, Brazil.
RP De Araujo, G (reprint author), Al Casa Branca 799-53G, BR-01408001 Sao Paulo, Brazil.
EM lela_araujo@hotmail.com
CR Ajuriag-uerra J., 1984, PSYCHOPATHOLOGIE ENF
   Ansermet F., 1999, CLIN ORIGINE ENFANT
   Benson PR, 2008, RES AUTISM SPECT DIS, V2, P583, DOI 10.1016/j.rasd.2007.12.002
   Brazelton T. B., 1983, NAISSANCE FAMILLE CO
   Clouard C, 2007, PSYCHIAT ENFANT, V50, P571
   COSNIER J, 1984, PSYCHIAT ENFANT, V27, P107
   Crespin G., 2004, CLIN PRECOCE NASCIME
   Crespin G., 2004, CAHIERS PREAUT, V1, P4149
   Crespin G., 2007, EPOPEE SYMBOLIQUE NO
   Freud S., 2010, OBRAS COMPLETAS, V12, P13150
   Freud S, 1968, METAPSYCHOLOGIE, P11
   Goldberg WA, 2005, J AUTISM DEV DISORD, V35, P657, DOI 10.1007/s10803-005-0009-6
   Golse B, 2007, PSYCHIAT ENFANT, V50, P29
   Gorwood P., 2005, AUTISME ETAT LIEUX H, P71
   Haag G., 2005, REV FRANCAISE PSYCHO, V27, P113
   Hochmann J., 2005, AUTISME ETAT LIEUX H, P107
   Hochmann J., 2007, REV FRANCAISE PSYCHA, V71
   Hoffmann C., 1992, CLIN AUTISME, P9
   Houzel D., 2003, ENFANT SES PARENTS P, P293
   Kupfer M. C., 2008, PSICANALISE COM CRIA, P221
   Lacan J., 1999, ECRITS, P235
   Lacan J., 1973, SEMINAIRE, P113
   Laznik M. C., 2007, LANGAGE VOIX PAROLE, P38
   Laznik M. C., 2004, VOZ SEREIA
   Laznik M. C., 2000, CELIBATAIRE REV PSYC, P67
   Laznik M. C., 2000, REV PSYCHANALYSE ENF, V28, P103
   Laznik M. C., 2006, CONTRASTE REV ANECAM, P53
   Lerner R., 2008, PSICANALISE COM CRIA
   Muratori F., 2005, COMMENCEMENT ETAIT V, P182
   Osborne LA, 2008, RES AUTISM SPECT DIS, V2, P249, DOI 10.1016/j.rasd.2007.06.004
   Pilowsky T, 2007, J AUTISM DEV DISORD, V37, P537, DOI 10.1007/s10803-006-0185-z
   Tardif C., 2007, AUTISME
   Trevarthen C, 2003, PSYCHIAT ENFANT, V46, P471
   Trouve J.-N., 2004, CAHIERS PREAUT, V1, P11
   Trouve J.-N., 2002, DIALOGUE RECHERCHES, V157, P63
   Winnicott D. W., 1989, PEDIAT PSYCHANALYSE, P285
   Yirmiya N, 2006, J CHILD PSYCHOL PSYC, V47, P511, DOI 10.1111/j.1469-7610.2005.01528.x
NR 37
TC 0
Z9 0
PU PRESSES UNIV FRANCE
PI PARIS CEDEX 14
PA 6 AVENUE REILLE, 75685 PARIS CEDEX 14, FRANCE
SN 0079-726X
J9 PSYCHIAT ENFANT
JI Psychiatr. Enfant
PY 2013
VL 56
IS 1
BP 147
EP 173
PG 27
WC Psychiatry
SC Psychiatry
GA AI7LM
UT WOS:000337072100006
ER

PT J
AU Donville, B
AF Donville, Barbara
TI THE STRANGE LOOP OF STEREROTYPIES
SO PSYCHIATRIE DE L ENFANT
LA French
DT Article
DE Autism; Strange loop; Articulated body; Fragmented body; Imitation;
   Intentionality; Repetition; Stereotypie; Subjectivity; Temporality
AB One of the characteristic traits commonly cited in autism is the stereotypie. In this article, on the basis of the clinical observation of an autistic child who was educated in our care, we will attempt to show that the autistic stereotypic is not a kind of repetition but what Douglas Hofstadter calls a "strange loop".
RP Donville, B (reprint author), 7 Rrue Commandant Leandri, F-75015 Paris, France.
EM barbara.donville@free.fr
CR Badiou Alain, 1988, ETRE EVENEMENT
   Deleuze G., 1968, DIFFERENCE REPETITIO
   Hofstadter D., 1985, GODEL ESCHER BACH BR
   PENROSE LS, 1958, BRIT J PSYCHOL, V49, P31
NR 4
TC 0
Z9 0
PU PRESSES UNIV FRANCE
PI PARIS CEDEX 14
PA 6 AVENUE REILLE, 75685 PARIS CEDEX 14, FRANCE
SN 0079-726X
J9 PSYCHIAT ENFANT
JI Psychiatr. Enfant
PY 2013
VL 56
IS 1
BP 175
EP 193
PG 19
WC Psychiatry
SC Psychiatry
GA AI7LM
UT WOS:000337072100007
ER

PT J
AU Miller, L
   McIntosh, RD
AF Miller, L.
   McIntosh, R. D.
TI Visual and proprioceptive cue weighting in children with Developmental
   Coordination Disorder, Autism Spectrum Disorder and typical development
SO I-PERCEPTION
LA English
DT Meeting Abstract
C1 [Miller, L.; McIntosh, R. D.] Univ Edinburgh, Edinburgh EH8 9YL, Midlothian, Scotland.
EM L.Miller-8@sms.ed.ac.uk
NR 0
TC 0
Z9 0
PU PION LTD
PI LONDON
PA 207 BRONDESBURY PARK, LONDON NW2 5JN, ENGLAND
SN 2041-6695
J9 I-PERCEPTION
JI I-Perception
PY 2013
VL 4
IS 7
BP 486
EP 486
PG 1
WC Psychology, Experimental
SC Psychology
GA AI0VM
UT WOS:000336568300011
ER

PT J
AU Van de Cruys, S
   de-Wit, L
   Evers, K
   Boets, B
   Wagemans, J
AF Van de Cruys, Sander
   de-Wit, Lee
   Evers, Kris
   Boets, Bart
   Wagemans, Johan
TI Weak priors versus overfitting of predictions in autism: Reply to
   Pellicano and Burr (TICS, 2012)
SO I-PERCEPTION
LA English
DT Editorial Material
DE autism; vision; perception; predictive coding; priors; Bayes
ID MISMATCH NEGATIVITY; PERCEPTION; WORLD
AB Pellicano and Burr (2012) argue that a Bayesian framework can help us understand the perceptual peculiarities in autism. We agree, but we think that their assumption of uniformly flat or equivocal priors in autism is not empirically supported. Moreover, we argue that any full account has to take into consideration not only the nature of priors in autism, but also how these priors are constructed or learned. We argue that predictive coding provides a more constrained framework that very naturally explains how priors are constructed in autism leading to strong, but overfitted, and non-generalizable predictions.
C1 [Van de Cruys, Sander; de-Wit, Lee; Evers, Kris; Boets, Bart; Wagemans, Johan] Univ Louvain, Dept Expt Psychol, Louvain, Belgium.
RP Van de Cruys, S (reprint author), Univ Louvain, Dept Expt Psychol, Tiensestr 102, Louvain, Belgium.
EM sander.vandecruys@ppw.kuleuven.be; lee.dewit@ppw.kuleuven.be;
   kris.evers@ppw.kuleuven.be; bart.boets@ppw.kuleuven.be;
   johan.wagemans@ppw.kuleuven.be
RI Van de Cruys, Sander/F-8996-2015
OI Van de Cruys, Sander/0000-0003-4831-7800
CR Brock J, 2012, TRENDS COGN SCI, V16, P573, DOI 10.1016/j.tics.2012.10.005
   Ciesielski KT, 1997, CHILD NEUROPSYCHOL, V3, P1, DOI 10.1080/09297049708401364
   Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018
   Feldman J, 2013, TOP COGN SCI, V5, P13, DOI 10.1111/tops.12003
   Ferri R, 2003, CLIN NEUROPHYSIOL, V114, P1671, DOI 10.1016/S1388-2457(03)00153-6
   Friston KJ, 2010, NAT REV NEUROSCI, V11, P127, DOI 10.1038/nrn2787
   Friston KJ, 2013, TRENDS COGN SCI, V17, P1, DOI 10.1016/j.tics.2012.11.003
   Kok P, 2012, CEREB CORTEX, V22, P2197, DOI 10.1093/cercor/bhr310
   Kujala T, 2007, BIOL PSYCHOL, V75, P109, DOI 10.1016/j.biopsycho.2006.12.007
   Mitchell P, 2004, INFANT CHILD DEV, V13, P185, DOI 10.1002/icd.348
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Pellicano E, 2012, TRENDS COGN SCI, V16, P504, DOI 10.1016/j.tics.2012.08.009
NR 12
TC 5
Z9 5
PU PION LTD
PI LONDON
PA 207 BRONDESBURY PARK, LONDON NW2 5JN, ENGLAND
SN 2041-6695
J9 I-PERCEPTION
JI I-Perception
PY 2013
VL 4
IS 2
BP 95
EP 97
DI 10.1068/i0580ic
PG 3
WC Psychology, Experimental
SC Psychology
GA AI0UN
UT WOS:000336565700002
PM 23755353
ER

PT J
AU Ronay, R
   Carney, DR
AF Ronay, Richard
   Carney, Dana R.
TI Testosterone's Negative Relationship With Empathic Accuracy and
   Perceived Leadership Ability
SO SOCIAL PSYCHOLOGICAL AND PERSONALITY SCIENCE
LA English
DT Article
DE nonverbal behavior; person perception; psychophysiology; social
   cognition; interpersonal processes
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; FETAL TESTOSTERONE;
   PERSPECTIVE-TAKING; PREFRONTAL CORTEX; NEURAL MECHANISMS; SOCIAL
   COGNITION; EYES TEST; BEHAVIOR; MIND
AB Two studies examine the relationship between naturally occurring levels of circulating testosterone and empathic accuracy. In Study 1, the authors find that higher endogenous levels of testosterone are negatively related to the accuracy with which people infer the thoughts and feelings of others. In Study 2, the authors use 360 data collected in the field to show that individuals with higher levels of endogenous testosterone are evaluated by their real-world professional colleagues as functioning with lower levels of empathic accuracy. Furthermore, the authors report evidence that this negative relationship between testosterone and perceived empathic accuracy has downstream consequences for perceptions of one's leadership skills and abilities.
C1 [Ronay, Richard] Columbia Univ, New York, NY USA.
   [Carney, Dana R.] Univ Calif Berkeley, Haas Sch Business, Berkeley, CA 94720 USA.
RP Ronay, R (reprint author), Columbia Business Sch, 7X Uris Hall, New York, NY 10027 USA.
EM r.ronay@columbia.edu
CR Anderson SW, 1999, NAT NEUROSCI, V2, P1032
   Baron-Cohen S., 2003, ESSENTIAL DIFFERENCE
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
   Batson CD, 2001, EUR J SOC PSYCHOL, V31, P25, DOI 10.1002/ejsp.26
   Carney DR, 2007, J RES PERS, V41, P1054, DOI 10.1016/j.jrp.2007.01.004
   Carney DR, 2010, J EXP SOC PSYCHOL, V46, P668, DOI 10.1016/j.jesp.2010.02.003
   Chapman E, 2006, SOC NEUROSCI, V1, P135, DOI 10.1080/17470910600992239
   Dabbs J. M., 2000, HEROES ROGUES LOVERS
   DAVIS MH, 1987, J PERS SOC PSYCHOL, V53, P397, DOI 10.1037/0022-3514.53.2.397
   Decety J, 2011, EMOT REV, V3, P92, DOI 10.1177/1754073910374662
   Emmelot-Vonk MH, 2008, JAMA-J AM MED ASSOC, V299, P39, DOI 10.1001/jama.2007.51
   Galinsky AD, 2000, J PERS SOC PSYCHOL, V78, P708, DOI 10.1037//0022-3514.78.4.708
   Galinsky AD, 2008, PSYCHOL SCI, V19, P378, DOI 10.1111/j.1467-9280.2008.02096.x
   Gleason KA, 2009, PERS SOC PSYCHOL B, V35, P997, DOI 10.1177/0146167209336605
   Granger DA, 1999, HORM BEHAV, V35, P18, DOI 10.1006/hbeh.1998.1492
   Hall J. A., 1984, NONVERBAL SEX DIFFER
   Hall J. A., 2005, HDB NONVERBAL BEHAV, P237
   Hayes AF, 2009, COMMUN MONOGR, V76, P408, DOI 10.1080/03637750903310360
   Hermans EJ, 2006, PSYCHONEUROENDOCRINO, V31, P859, DOI 10.1016/j.psyneuen.2006.04.002
   Ickes W., 1997, EMPATHIC ACCURACY
   Iyengar S., 2008, RIO COPA NEGOTIATION
   Jaccard J., 2003, INTERACTION EFFECTS
   LEVENSON RW, 1992, J PERS SOC PSYCHOL, V63, P234, DOI 10.1037/0022-3514.63.2.234
   Lutchmaya S, 2002, INFANT BEHAV DEV, V25, P327, DOI 10.1016/S0163-6383(02)00094-2
   Lutchmaya S, 2002, INFANT BEHAV DEV, V24, P418
   Mazur A, 1998, BEHAV BRAIN SCI, V21, P353
   Mehta PH, 2010, J COGNITIVE NEUROSCI, V22, P2357, DOI 10.1162/jocn.2009.21389
   Mitchell JP, 2009, PHILOS T R SOC B, V364, P1309, DOI 10.1098/rstb.2008.0318
   NOLLER P, 1994, J NONVERBAL BEHAV, V18, P199, DOI 10.1007/BF02170026
   NORMAN WT, 1966, J PERS SOC PSYCHOL, V4, P681, DOI 10.1037/h0024002
   NOWICKI S, 1992, J GENET PSYCHOL, V153, P385
   Preacher KJ, 2004, BEHAV RES METH INS C, V36, P717, DOI 10.3758/BF03206553
   REGAN DT, 1975, J PERS SOC PSYCHOL, V32, P850, DOI 10.1037//0022-3514.32.5.850
   Rubin RS, 2005, ACAD MANAGE J, V48, P845
   Schultheiss O.C., 2009, METHODS SOCIAL NEURO, P17
   Seitz RJ, 2006, NEUROPSYCHOLOGY, V20, P743, DOI 10.1037/0894-4105.20.6.743
   Stanton SJ, 2009, J RES PERS, V43, P942, DOI 10.1016/j.jrp.2009.04.001
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   TOI M, 1982, J PERS SOC PSYCHOL, V43, P281, DOI 10.1037/0022-3514.43.2.281
   van Honka J, 2011, P NATL ACAD SCI USA, V108, P3448, DOI 10.1073/pnas.1011891108
   van Honk J, 2007, PSYCHOL SCI, V18, P663, DOI 10.1111/j.1467-9280.2007.01955.x
   Zaki J., NATURE NEUR IN PRESS
   Zaki J, 2009, ANN NY ACAD SCI, V1167, P16, DOI 10.1111/j.1749-6632.2009.04601.x
   Zaki J, 2011, PSYCHOL INQ, V22, P159, DOI 10.1080/1047840X.2011.551743
NR 46
TC 8
Z9 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1948-5506
EI 1948-5514
J9 SOC PSYCHOL PERS SCI
JI Soc. Psychol. Personal Sci.
PD JAN
PY 2013
VL 4
IS 1
BP 92
EP 99
DI 10.1177/1948550612442395
PG 8
WC Psychology, Social
SC Psychology
GA AH9BR
UT WOS:000336434700013
ER

PT J
AU Abdallah, MW
   Hougaard, DM
   Norgaard-Pedersen, B
   Grove, J
   Bonefeld-Jorgensen, EC
   Mortensen, EL
AF Abdallah, M. W.
   Hougaard, D. M.
   Norgaard-Pedersen, B.
   Grove, J.
   Bonefeld-Jorgensen, E. C.
   Mortensen, E. L.
TI INFECTIONS DURING PREGNANCY AND AFTER BIRTH, AND THE RISK OF AUTISM
   SPECTRUM DISORDERS: A REGISTER-BASED STUDY UTILIZING A DANISH HISTORIC
   BIRTH COHORT
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Abdallah, M. W.] Aarhus Univ HLTH, Sect Epidemiol, Aarhus, Denmark.
   [Abdallah, M. W.; Hougaard, D. M.; Norgaard-Pedersen, B.] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark.
   [Abdallah, M. W.] Univ Rostock, Rostock Univ Hosp, Dept Psychiat & Psychotherapy, D-18055 Rostock, Germany.
   [Grove, J.] Aarhus Univ HLTH, Dept Biomed, Aarhus, Denmark.
   [Grove, J.] Aarhus Univ HLTH, Bioinformat Res Ctr BiRC, Aarhus, Denmark.
   [Bonefeld-Jorgensen, E. C.] Aarhus Univ HLTH, Ctr Arctic Environm Med, Aarhus, Denmark.
   [Bonefeld-Jorgensen, E. C.] Aarhus Univ HLTH, Unit Cellular & Mol Toxicol, Aarhus, Denmark.
   [Mortensen, E. L.] Univ Copenhagen, Inst Publ Hlth, Copenhagen, Denmark.
   [Mortensen, E. L.] Univ Copenhagen, Ctr Healthy Aging, Copenhagen, Denmark.
RI Bonefeld-Jorgensen, Eva Cecilie/A-1682-2015
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 869
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460600326
ER

PT J
AU Ali, D
   Effat, S
   El Serafi, D
AF Ali, D.
   Effat, S.
   El Serafi, D.
TI MOTOR DISTURBANCES IN AUTISTIC CHILDREN: CROSS SECTIONAL, CONTROLLED
   STUDY
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
DE Motor deficits; Essential feature; Autism; Children
C1 [Ali, D.] Prince Sultan Humanitarian City, Psychiat, Riyadh, Saudi Arabia.
   [Ali, D.; Effat, S.; El Serafi, D.] Ain Shams Univ, Cairo, Egypt.
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 1188
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460600560
ER

PT J
AU Derguy, C
   Bouvard, M
   M'bailara, K
   Ferreira, AD
   Croise, A
   Michel, G
AF Derguy, C.
   Bouvard, M.
   M'bailara, K.
   Ferreira, A. Denis
   Croise, A.
   Michel, G.
TI HAVING A CHILD WITH AUTISM: WHAT KIND OF NEEDS AND SUPPORT EXPECTATIONS
   FOR PARENTS?
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Derguy, C.; M'bailara, K.; Ferreira, A. Denis; Croise, A.; Michel, G.] Univ Bordeaux Segalen, Lab EA 4139, Bordeaux, France.
   [Derguy, C.; Bouvard, M.] Ctr Ressources Autisme Aquitaine, Bordeaux, France.
   [M'bailara, K.] Hosp Charles Perrens, Bordeaux, France.
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 2648
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460602082
ER

PT J
AU Dokukina, TV
AF Dokukina, T. V.
TI ASPECTS OF DISBALANCE MACRO- AND MICROELEMENTS IN CHILDREN WITH AUTISM
   SPECTRUM DISORDERS IN BELARUS
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Dokukina, T. V.] Belarusian State Univ, Republican Res & Pract Ctr Mental Hlth, Minsk, Byelarus.
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 1955
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460601599
ER

PT J
AU Fitzgerald, M
AF Fitzgerald, M.
TI Overlap autism and schizophrenia
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 592
DI 10.1016/S0924-9338(13)75865-6
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460600154
ER

PT J
AU Iakimova, G
   Mardaga, S
   Couvreux, M
   Hun, S
   Serret, S
   Askenazy, F
AF Iakimova, G.
   Mardaga, S.
   Couvreux, M.
   Hun, S.
   Serret, S.
   Askenazy, F.
TI CAN A TRAINING WITH VIDEO GAME OF SOCIAL COGNITION ENHANCE
   NEUROCOGNITIVE PROCESSES OF EMOTIONAL PERCEPTION IN AUTISM SPECTRUM?
   INSIGHTS OF EVENT-RELATED POTENTIALS
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Iakimova, G.; Mardaga, S.; Couvreux, M.] Univ Nice Sophia Antipolis, Lab Anthropol & Psychol Cognit & Sociales, F-06189 Nice, France.
   [Hun, S.; Serret, S.; Askenazy, F.] CHU Lenval, Serv Univ Psychiat Enfant & Adolescent, Hop Pediat, Ctr Ressources Autisme, Nice, France.
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 2263
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460601830
ER

PT J
AU Jedrzejczyk-Goral, B
   Flisiak-Antonijczuk, H
   Kalinowski, R
AF Jedrzejczyk-Goral, B.
   Flisiak-Antonijczuk, H.
   Kalinowski, R.
TI THE FREQUENCY OF DIFFERENT TYPES OF SEIZURES IN CHILDREN SUFFERED FROM
   AUTISM AND EPILEPSY
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Jedrzejczyk-Goral, B.; Flisiak-Antonijczuk, H.; Kalinowski, R.] Neuropsychiat Ctr Neuromed, Wroclaw, Poland.
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 1925
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460601576
ER

PT J
AU Kotrotsiou, E
   Dragioti, E
   Kitta, M
   Bakou, E
   Albani, E
   Mantzoukas, S
   Gouva, M
AF Kotrotsiou, E.
   Dragioti, E.
   Kitta, M.
   Bakou, E.
   Albani, E.
   Mantzoukas, S.
   Gouva, M.
TI DISCRIMINATION OF FAMILY ENVIRONMENT AMONG PARENTS OF CHILDREN WITH
   DIABETES AND PARENTS OF CHILDREN WITH AUTISM
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Kotrotsiou, E.] Higher Technol Educ Inst Larissa, Sch Hlth, Larisa, Greece.
   [Dragioti, E.] Sotiria Hosp, Dept Psychiat, Athens, Greece.
   [Kitta, M.; Bakou, E.; Albani, E.] Univ Thessaly, Med Sch Postgrad Program Primary Care Hlth, Larisa, Greece.
   [Mantzoukas, S.; Gouva, M.] Higher Technol Educ Inst Epirus, Sch Hlth, Ioannina, Greece.
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 1877
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460601539
ER

PT J
AU Lam, PWK
AF Lam, P. W. K.
TI COMORBID AUTISM SPECTRUM DISORDER AND PROBLEM BEHAVIOURS: A CASE STUDY
   OF HOME-BASED SENSORY INTEGRATIVE THERAPY
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Lam, P. W. K.] Christian Family Serv Ctr, Integrated Rehabil Serv, Hong Kong, Hong Kong, Peoples R China.
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 1193
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460600565
ER

PT J
AU Shtayermman, O
AF Shtayermman, O.
TI Stress and marital satisfaction of parents to children diagnosed with
   autism
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 343
DI 10.1016/S0924-9338(13)75737-7
PG 2
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460600026
ER

PT J
AU van der Ven, E
   Termorshuizen, F
   Laan, W
   Breetvelt, E
   van Os, J
   Selten, JP
AF van der Ven, E.
   Termorshuizen, F.
   Laan, W.
   Breetvelt, E.
   van Os, J.
   Selten, J. -P.
TI An incidence study of diagnosed autism-spectrum disorders among
   immigrants to the netherlands
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 826
DI 10.1016/S0924-9338(13)76001-2
PG 2
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460600290
ER

PT J
AU Woolf, R
   Carroll, L
   Ibrahim, Y
   Owen, M
   O' Donovan, M
AF Woolf, R.
   Carroll, L.
   Ibrahim, Y.
   Owen, M.
   O' Donovan, M.
TI LARGE-SCALE MUTATION SCREENING OF THE PUTATIVE AUTISM SUSCEPTIBILITY
   GENE SCN2A IN SCHIZOPHRENIA
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Woolf, R.; Carroll, L.; Ibrahim, Y.; Owen, M.; O' Donovan, M.] MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales.
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 2788
PG 1
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460602183
ER

PT J
AU Yoshimasu, K
AF Yoshimasu, K.
TI Childhood autism, adhd, and mercury exposures: a meta-analysis
SO EUROPEAN PSYCHIATRY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PY 2013
VL 28
SU 1
MA 763
DI 10.1016/S0924-9338(13)75968-6
PG 2
WC Psychiatry
SC Psychiatry
GA AG5LN
UT WOS:000335460600257
ER

PT J
AU Grubb, MA
   Behrmann, M
   Egan, R
   Minshew, NJ
   Heeger, DJ
   Carrasco, M
AF Grubb, Michael A.
   Behrmann, Marlene
   Egan, Ryan
   Minshew, Nancy J.
   Heeger, David J.
   Carrasco, Marisa
TI Exogenous spatial attention: Evidence for intact functioning in adults
   with autism spectrum disorder
SO JOURNAL OF VISION
LA English
DT Article
DE covert attention; exogenous attention; crowding; visual search; contrast
   sensitivity; adults; autism; ASD
ID SUPERIOR VISUAL-SEARCH; COVERT ATTENTION; CONTRAST SENSITIVITY; OBJECT
   RECOGNITION; TIME-COURSE; PERFORMANCE; ENHANCEMENT; ECCENTRICITY;
   RESOLUTION; REFLEXIVE
AB Deficits or atypicalities in attention have been reported in individuals with autism spectrum disorder (ASD), yet no consensus on the nature of these deficits has emerged. We conducted three experiments that paired a peripheral precue with a covert discrimination task, using protocols for which the effects of covert exogenous spatial attention on early vision have been well established in typically developing populations. Experiment 1 assessed changes in contrast sensitivity, using orientation discrimination of a contrast-defined grating; Experiment 2 evaluated the reduction of crowding in the visual periphery, using discrimination of a letter-like figure with flanking stimuli at variable distances; and Experiment 3 assessed improvements in visual search, using discrimination of the same letter-like figure with a variable number of distractor elements. In all three experiments, we found that exogenous attention modulated visual discriminability in a group of high-functioning adults with ASD and that it did so in the same way and to the same extent as in a matched control group. We found no evidence to support the hypothesis that deficits in exogenous spatial attention underlie the emergence of core ASD symptomatology.
C1 [Grubb, Michael A.; Heeger, David J.; Carrasco, Marisa] NYU, Dept Psychol, New York, NY 10003 USA.
   [Grubb, Michael A.; Heeger, David J.; Carrasco, Marisa] NYU, Ctr Neural Sci, New York, NY 10003 USA.
   [Behrmann, Marlene; Egan, Ryan] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
   [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
   [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA.
RP Carrasco, M (reprint author), NYU, Dept Psychol, 6 Washington Pl, New York, NY 10003 USA.
EM marisa.carrasco@nyu.edu
FU NIH [R01-EY019693]; SFARI [177638]; ACE [HD055748]; Autism Speaks
   predoctoral fellowship [7831]
FX This research was supported by NIH grant R01-EY019693 to DH and MC, by
   SFARI grant 177638 to DH and MB, by ACE grant HD055748 to NM, and by
   Autism Speaks predoctoral fellowship 7831 to MG.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003
   Anton-Erxleben K, 2013, NAT REV NEUROSCI, V14, P188, DOI 10.1038/nrn3443
   Baldassi S, 2009, VISION RES, V49, P2151, DOI 10.1016/j.visres.2009.06.007
   Cameron EL, 2002, VISION RES, V42, P949, DOI 10.1016/S0042-6989(02)00039-1
   Carrasco M, 2011, VISION RES, V51, P1484, DOI 10.1016/j.visres.2011.04.012
   Carrasco M, 1998, J EXP PSYCHOL HUMAN, V24, P673, DOI 10.1037//0096-1523.24.2.673
   Carrasco M, 2004, VISION RES, V44, P1351, DOI 10.1016/j.visres.2003.11.026
   Carrasco M, 2001, P NATL ACAD SCI USA, V98, P5363, DOI 10.1073/pnas.081074098
   Carrasco M, 2006, VISION RES, V46, P2028, DOI 10.1016/j.visres.2005.12.015
   Carrasco M, 2004, NAT NEUROSCI, V7, P308, DOI 10.1038/nn1194
   Carrasco M, 2000, VISION RES, V40, P1203, DOI 10.1016/S0042-6989(00)00024-9
   Chawarska K, 2003, CHILD DEV, V74, P1108, DOI 10.1111/1467-8624.00595
   Constable PA, 2010, CLIN OPTOMETRY, V2, P93
   Fan J., 2012, NEUROSCIENCE AUTISM, P281
   Giordano AM, 2009, J VISION, V9, DOI 10.1167/9.3.30
   Grubb MA, 2013, AUTISM RES, V6, P108, DOI 10.1002/aur.1269
   Haist F, 2005, DEV NEUROPSYCHOL, V27, P425, DOI 10.1207/s15326942dn2703_7
   Herrmann K, 2010, NAT NEUROSCI, V13, P1554, DOI 10.1038/nn.2669
   Hopfinger JB, 1998, PSYCHOL SCI, V9, P441, DOI 10.1111/1467-9280.00083
   Iarocci G, 2004, J AUTISM DEV DISORD, V34, P257, DOI 10.1023/B:JADD.0000029548.84041.69
   Kanner L, 1943, NERV CHILD, V2, P217
   Keehn B, 2013, NEUROSCI BIOBEHAV R, V37, P164, DOI 10.1016/j.neubiorev.2012.11.014
   Keita L, 2010, AUTISM RES, V3, P333, DOI 10.1002/aur.164
   Kimchi R, 2008, PSYCHOL SCI, V19, P660, DOI 10.1111/j.1467-9280.2008.02140.x
   Levi DM, 2008, VISION RES, V48, P635, DOI 10.1016/j.visres.2007.12.009
   Liu TS, 2005, NEURON, V45, P469, DOI 10.1016/j.neuron.2004.12.039
   Liu TS, 2007, VISION RES, V47, P108, DOI 10.1016/j.visres.2006.09.017
   MULLER HJ, 1989, J EXP PSYCHOL HUMAN, V15, P315, DOI 10.1037/0096-1523.15.2.315
   NACHMIAS J, 1967, J OPT SOC AM, V57, P421, DOI 10.1364/JOSA.57.000421
   NAKAYAMA K, 1989, VISION RES, V29, P1631, DOI 10.1016/0042-6989(89)90144-2
   O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719
   O'Riordan MA, 2004, AUTISM, V8, P229, DOI 10.1177/1362361304045219
   Pelli DG, 2008, NAT NEUROSCI, V11, P1129, DOI 10.1038/nn.2187
   Pestilli F, 2009, VISION RES, V49, P1144, DOI 10.1016/j.visres.2008.09.018
   Renner P, 2006, CHILD NEUROPSYCHOL, V12, P361, DOI 10.1080/09297040600770753
   Robertson CE, 2013, J NEUROSCI, V33, P6776, DOI 10.1523/JNEUROSCI.5120-12.2013
   Rolfs M, 2012, J NEUROSCI, V32, P13744, DOI 10.1523/JNEUROSCI.2676-12.2012
   Scolari M, 2007, J VISION, V7, DOI 10.1167/7.2.7
   Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005
   Townsend J, 2010, HANDBOOK OF MEDICAL NEUROPSYCHOLOGY: APPLICATIONS OF COGNITIVE NEUROSCIENCE, P165, DOI 10.1007/978-1-4419-1364-7_10
   Townsend J, 1996, J Int Neuropsychol Soc, V2, P541
   WATSON AB, 1983, PERCEPT PSYCHOPHYS, V33, P113, DOI 10.3758/BF03202828
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Yeshurun Y, 1998, NATURE, V396, P72
   Yeshurun Y, 2010, J VISION, V10, DOI 10.1167/10.10.16
NR 46
TC 4
Z9 4
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 1534-7362
J9 J VISION
JI J. Vision
PY 2013
VL 13
IS 14
AR 9
DI 10.1167/13.14.9
PG 13
WC Ophthalmology
SC Ophthalmology
GA AG8IN
UT WOS:000335662100009
ER

PT J
AU Pop, CA
   Simut, RE
   Pintea, S
   Saldien, J
   Rusu, AS
   Vanderfaeillie, J
   David, DO
   Lefeber, D
   Vanderborght, B
AF Pop, Cristina A.
   Simut, Ramona E.
   Pintea, Sebastian
   Saldien, Jelle
   Rusu, Alina S.
   Vanderfaeillie, Johan
   David, Daniel O.
   Lefeber, Dirk
   Vanderborght, Bram
TI SOCIAL ROBOTS VS. COMPUTER DISPLAY: DOES THE WAY SOCIAL STORIES ARE
   DELIVERED MAKE A DIFFERENCE FOR THEIR EFFECTIVENESS ON ASD CHILDREN?
SO JOURNAL OF EDUCATIONAL COMPUTING RESEARCH
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM;
   ASSISTED-INSTRUCTION; TEACHING-CHILDREN; ASPERGER-SYNDROME;
   VIRTUAL-REALITY; PEOPLE; SKILLS; INTERVENTION; RECOGNIZE
AB Background and Objectives: The aim of this exploratory study is to test whether social stories presented by a social robot have a greater effect than ones presented on a computer display in increasing the independency in expressing social abilities of children with autism spectrum disorders (ASD). Although much progress has been made in developing interventions to improve social skills of children with ASD, a number of unresolved problems still remain. Social robots received increased attention as assisting tools for improving social skills on children with ASD. Methods: Twenty children with ASD (age between 4 and 9 years old) were randomly allocated to three groups: control group (n = 7), computer-presented social stories (n = 6), and robot assisted therapy (n = 7). Results: Overall, our data indicate that using the social robot to implement social story intervention was more effective for improving the independency of expressing social abilities for the participants, than the computer screen. Limitations: Future studies should include a bigger sample size, more intervention sessions, and a follow-up session in order to see if the effect persists in time. Conclusions: The preliminary outcomes of this exploratory research provide empirical bases for further investigations regarding the effectiveness of robot assisted therapy in improving social skills for children with autism through future randomized clinical trials.
C1 [Pop, Cristina A.; Simut, Ramona E.; Pintea, Sebastian; Saldien, Jelle; Rusu, Alina S.; Vanderfaeillie, Johan; David, Daniel O.; Lefeber, Dirk; Vanderborght, Bram] Univ Babes Bolyai, Cluj Napoca 400015, Cluj, Romania.
RP Pop, CA (reprint author), Univ Babes Bolyai, Dept Clin Psychol & Psychotherapy, 37 Republicii St, Cluj Napoca 400015, Cluj, Romania.
EM pop.cristina@ubbcluj.ro
RI David, Daniel/N-1285-2014
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Azevedo R, 1995, J EDUC COMPUT RES, V13, P111, DOI 10.2190/9LMD-3U28-3A0G-FTQT
   Bainbridge WA, 2008, 2008 17TH IEEE INTERNATIONAL SYMPOSIUM ON ROBOT AND HUMAN INTERACTIVE COMMUNICATION, VOLS 1 AND 2, P701, DOI 10.1109/ROMAN.2008.4600749
   Barron A. E., 2006, HDB RES LITERACY TEC
   Barry L. M., 2004, FOCUS AUTISM OTHER D, V19, P45, DOI DOI 10.1177/10883576040190010601
   BERNARD-OPITZ V, 1990, Annals Academy of Medicine Singapore, V19, P611
   Bernard-Opitz V, 2001, J AUTISM DEV DISORD, V31, P377, DOI 10.1023/A:1010660502130
   Billard A, 2003, ROBOT AUTON SYST, V42, P259, DOI 10.1016/S0921-8890(02)00380-9
   Blischak DM, 2003, TOP LANG DISORD, V23, P293
   Breazeal C., 2004, P INT C INT ROB SYST, V4, P3559, DOI DOI 10.1109/IR0S.2004.1389967
   Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
   Dautenhahn K, 2004, PRAGMAT COGN, V12, P1, DOI DOI 10.1075/PC.12.1.03DAU
   David D., 2010, RATIONAL IRRATIONAL
   Diehl JJ, 2012, RES AUTISM SPECT DIS, V6, P249, DOI 10.1016/j.rasd.2011.05.006
   Ferrari Ester, 2009, RO-MAN 2009 - The 18th IEEE International Symposium on Robot and Human Interactive Communication, DOI 10.1109/ROMAN.2009.5326251
   Fitzgerald G, 2008, J EDUC COMPUT RES, V38, P201, DOI 10.2190/EC.38.2.e
   Francois D, 2009, INTERACT STUD, V10, P324, DOI 10.1075/is.10.3.04fra
   Giannopulu I, 2010, NEUROREHABILITATION, V27, P305, DOI 10.3233/NRE-2010-0613
   Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305
   Goris K, 2011, INT J HUM ROBOT, V8, P481, DOI 10.1142/S0219843611002563
   Gray C., 2000, NEW SOCIAL STORY BOO
   Gray C. A, 2004, JENISON AUTISM J, V15, P2
   Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
   Hadwin J., 1999, TEACHING CHILDREN AU
   Happe F. G. E., 2005, HDB AUTISM PERVASIVE, V1, P640
   Inan FA, 2010, TEACH TEACH EDUC, V26, P540, DOI 10.1016/j.tate.2009.06.017
   Jones EA, 2006, BEHAV MODIF, V30, P782, DOI 10.1177/0145445506289392
   Kim EE, 2012, CURR MED IMAGING REV, V8, P1
   Kokina A, 2010, J AUTISM DEV DISORD, V40, P812, DOI 10.1007/s10803-009-0931-0
   Kozima H, 2009, INT J SOC ROBOT, V1, P3, DOI 10.1007/s12369-008-0009-8
   Leyzberg D., 2012, P 34 ANN C COGN SCI
   Lord C., 2001, DIVISION BEHAV SOCIA
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MACDUFF GS, 1993, J APPL BEHAV ANAL, V26, P89, DOI 10.1901/jaba.1993.26-89
   Moore D, 2000, INNOV EDUC TRAIN INT, V37, P218
   Moore D., 2000, J ED MEDIA, V25, P169
   Moore M, 2000, J AUTISM DEV DISORD, V30, P359, DOI 10.1023/A:1005535602064
   Myles B. S., 1999, FOCUS AUTISM OTHER D, V14, P82, DOI 10.1177/108835769901400203
   OZONOFF S, 1995, NEUROPSYCHOLOGY, V9, P491, DOI 10.1037//0894-4105.9.4.491
   Parsons S, 2002, J INTELL DISABIL RES, V46, P430, DOI 10.1046/j.1365-2788.2002.00425.x
   Quill KA, 1997, J AUTISM DEV DISORD, V27, P697, DOI 10.1023/A:1025806900162
   Ramdoss S., 2011, J BEHAV ED, V20, P55, DOI 10.1007/s10864-010-9112-7
   Ricks DJ, 2010, IEEE INT CONF ROBOT, P4354, DOI 10.1109/ROBOT.2010.5509327
   Robins B, 2006, INTERACTION STUDIES, V7, P509, DOI 10.1075/is.7.3.16rob
   Robins B, 2010, 2010 IEEE RO-MAN, P704, DOI 10.1109/ROMAN.2010.5598641
   Saldien J, 2010, INT J SOC ROBOT, V2, P377, DOI 10.1007/s12369-010-0067-6
   Sansosti FJ, 2008, J POSIT BEHAV INTERV, V10, P162, DOI 10.1177/1098300708316259
   Scassellati B., 2005, IEEE INT WORKSH ROB, P585, DOI DOI 10.1109/R0MAN.2005.1513843
   Scassellati B, 2012, ANNU REV BIOMED ENG, V14, P275, DOI 10.1146/annurev-bioeng-071811-150036
   Scattone D, 2007, PSYCHOL SCHOOLS, V44, P717, DOI 10.1002/pits.20260
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Shane HC, 2008, J AUTISM DEV DISORD, V38, P1499, DOI 10.1007/s10803-007-0527-5
   Silver M, 2001, AUTISM, V5, P299, DOI 10.1177/1362361301005003007
   Strickland D, 1997, ST HEAL T, V44, P81
   Swaggart B. L., 1995, FOCUS AUTISTIC BEHAV, V10, P1
   Tapus Adriana, 2009, RO-MAN 2009 - The 18th IEEE International Symposium on Robot and Human Interactive Communication, DOI 10.1109/ROMAN.2009.5326211
   Tapus A, 2012, INTERACT STUD, V13, P315, DOI 10.1075/is.13.3.01tap
   Vanderborght B, 2012, INTERACT STUD, V13, P348, DOI 10.1075/is.13.3.02van
   Wainer J., 2007, IEEE P INT WORKSH RO, P872
   Williams C, 2002, AUTISM, V6, P71, DOI 10.1177/1362361302006001006
   Wilson J, 1988, HDB HUMAN COMPUTER I, P859
NR 61
TC 1
Z9 1
PU BAYWOOD PUBL CO INC
PI AMITYVILLE
PA 26 AUSTIN AVE, PO BOX 337, AMITYVILLE, NY 11701 USA
SN 0735-6331
EI 1541-4140
J9 J EDUC COMPUT RES
JI J. Educ. Comput. Res.
PY 2013
VL 49
IS 3
BP 381
EP 401
DI 10.2190/EC.49.3.f
PG 21
WC Education & Educational Research
SC Education & Educational Research
GA AF7MY
UT WOS:000334900400006
ER

PT J
AU Tavares, P
   Mouga, S
   Oliveira, G
   Castelo-Branco, M
AF Tavares, P.
   Mouga, S.
   Oliveira, G.
   Castelo-Branco, M.
TI Preserved first-order configural and holistic face processing in
   high-functioning adults with autism: an EEG/ERP study
SO PERCEPTION
LA English
DT Meeting Abstract
C1 [Tavares, P.; Mouga, S.; Oliveira, G.; Castelo-Branco, M.] Univ Coimbra, Fac Med, IBILI, P-3000 Coimbra, Portugal.
EM pmtavares@fmed.uc.pt
NR 0
TC 0
Z9 0
PU PION LTD
PI LONDON
PA 207 BRONDESBURY PARK, LONDON NW2 5JN, ENGLAND
SN 0301-0066
EI 1468-4233
J9 PERCEPTION
JI Perception
PY 2013
VL 42
SU S
BP 81
EP 81
PG 1
WC Psychology; Psychology, Experimental
SC Psychology
GA AF7NE
UT WOS:000334901000253
ER

PT J
AU Ainsworth, K
   Garrod, O
   Jack, RE
   Holcomb, C
   Adolphs, R
   Schyns, P
   Simmons, D
AF Ainsworth, K.
   Garrod, O.
   Jack, R. E.
   Holcomb, C.
   Adolphs, R.
   Schyns, P.
   Simmons, D.
TI Perceptions of Facial Expressions of Emotion in Autism Spectrum
   Disorders: Reading the "minds eye" Using Reverse Correlation
SO PERCEPTION
LA English
DT Meeting Abstract
C1 [Ainsworth, K.; Garrod, O.; Jack, R. E.; Schyns, P.; Simmons, D.] Univ Glasgow, Sch Psychol, Glasgow G12 8QQ, Lanark, Scotland.
   [Holcomb, C.; Adolphs, R.] CALTECH, Pasadena, CA 91125 USA.
EM kirstya@psy.gla.ac.uk
RI Simmons, David/A-4916-2012
NR 0
TC 0
Z9 0
PU PION LTD
PI LONDON
PA 207 BRONDESBURY PARK, LONDON NW2 5JN, ENGLAND
SN 0301-0066
EI 1468-4233
J9 PERCEPTION
JI Perception
PY 2013
VL 42
SU S
BP 82
EP 82
PG 1
WC Psychology; Psychology, Experimental
SC Psychology
GA AF7NE
UT WOS:000334901000254
ER

PT J
AU Pereverzeva, D
AF Pereverzeva, D.
TI Diagnostic and correction of visual object recognition in preschool
   children with Autism spectrum disorders (ASD)
SO PERCEPTION
LA English
DT Meeting Abstract
C1 [Pereverzeva, D.] Moscow State Univ Psychol & Educ, Ctr Neurobiol Diag Hereditary Mental Disorders Ch, Moscow, Russia.
EM dasha.pereverzeva@gmail.com
NR 0
TC 0
Z9 0
PU PION LTD
PI LONDON
PA 207 BRONDESBURY PARK, LONDON NW2 5JN, ENGLAND
SN 0301-0066
EI 1468-4233
J9 PERCEPTION
JI Perception
PY 2013
VL 42
SU S
BP 82
EP 82
PG 1
WC Psychology; Psychology, Experimental
SC Psychology
GA AF7NE
UT WOS:000334901000256
ER

PT J
AU Whitaker, L
   Jones, CR
   Wilkins, A
   Roberson, D
AF Whitaker, L.
   Jones, C. R.
   Wilkins, A.
   Roberson, D.
TI Individuals with autism spectrum disorders benefit from the addition of
   coloured tints when discriminating intensities of facial expressions
SO PERCEPTION
LA English
DT Meeting Abstract
C1 [Whitaker, L.; Jones, C. R.; Wilkins, A.; Roberson, D.] Univ Essex, Psychol Dept, Colchester CO4 3SQ, Essex, England.
EM lwhita@essex.ac.uk
NR 0
TC 0
Z9 0
PU PION LTD
PI LONDON
PA 207 BRONDESBURY PARK, LONDON NW2 5JN, ENGLAND
SN 0301-0066
EI 1468-4233
J9 PERCEPTION
JI Perception
PY 2013
VL 42
SU S
BP 82
EP 82
PG 1
WC Psychology; Psychology, Experimental
SC Psychology
GA AF7NE
UT WOS:000334901000255
ER

PT J
AU Lord, C
   Jones, RM
AF Lord, Catherine
   Jones, Rebecca M.
BE Walkup, JT
   Shaffer, D
   Lee, FS
TI New strategies and findings for behavioral interventions in autism
   spectrum disorders
SO CHILDHOOD ONSET DEVELOPMENTAL DISORDERS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 92nd Annual Conference of the
   Association-for-Research-in-Nervous-and-Mental-Disease (ARNMD) on
   Childhood Onset Developmental Disorders
CY DEC, 2012
CL New York, NY
SP Assoc Res Nervous & Mental Dis
DE autism spectrum disorders; behavioral interventions; caregiver training;
   parent-mediated training
ID RANDOMIZED CONTROLLED-TRIAL; YOUNG-CHILDREN; RESEARCH UNITS; DENVER
   MODEL; RISPERIDONE; PREDICTORS; DISABILITY; ABILITIES; PATTERNS;
   TODDLERS
AB Behavioral interventions are the major source of change for children with autism spectrum disorders and a major cost to families and government. In the last 5 years, a number of carefully designed intervention studies have provided new information about the effects of caregiver training and direct instruction on behavior treatments. Outcomes of these interventions are neither easily assessed nor simple, but are dependent on child characteristics as well as caregiver skills and attitudes. Some interventions aimed at specific skills have similar results, yet there is growing evidence that child interventions may have different effects than caregiver training, although both may affect outcomes in the long term. New research strategies and findings are discussed, with a focus on how underlying behaviors and specific components may contribute to intervention outcomes.
C1 [Lord, Catherine; Jones, Rebecca M.] NewYork Presbyterian Hosp, Weill Cornell Med Coll, Westchester Div, Dept Psychiat,Ctr Autism & Dev Brain, White Plains, NY 10605 USA.
RP Lord, C (reprint author), NewYork Presbyterian Hosp, Weill Cornell Med Coll, Westchester Div, Dept Psychiat,Ctr Autism & Dev Brain, White Plains, NY 10605 USA.
EM cal2028@med.cornell.edu
CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
   Anderson D., J CHILD PSY IN PRESS
   Anderson DK, 2009, J ABNORM CHILD PSYCH, V37, P1019, DOI 10.1007/s10802-009-9326-0
   Anderson DK, 2007, J CONSULT CLIN PSYCH, V75, P594, DOI 10.1037/0022-006X.75.4.594
   Anderson DK, 2011, AJIDD-AM J INTELLECT, V116, P381, DOI 10.1352/1944-7558-116.5.381
   Arnold LE, 2010, J CHILD ADOL PSYCHOP, V20, P83, DOI 10.1089/cap.2009.0022
   Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
   Cohen H, 2006, J DEV BEHAV PEDIATR, V27, pS145, DOI 10.1097/00004703-200604002-00013
   Coolican J, 2010, J CHILD PSYCHOL PSYC, V51, P1321, DOI 10.1111/j.1469-7610.2010.02326.x
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Dichter GS, 2012, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095
   Frankel F, 2010, J AUTISM DEV DISORD, V40, P827, DOI 10.1007/s10803-009-0932-z
   Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237
   Gotham K, 2012, PEDIATRICS, V130, pE1278, DOI 10.1542/peds.2011-3668
   Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
   Hayward D, 2009, AUTISM, V13, P613, DOI 10.1177/1362361309340029
   Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
   Jahromi LB, 2009, J AUTISM DEV DISORD, V39, P395, DOI 10.1007/s10803-008-0636-9
   Kasari C, 2012, J AM ACAD CHILD PSY, V51, P487, DOI 10.1016/j.jaac.2012.02.019
   Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
   Lampi KM, 2012, J PEDIATR-US, V161, P830, DOI 10.1016/j.jpeds.2012.04.058
   Landa Rebecca J, 2012, Pediatrics, V130 Suppl 2, pS186, DOI 10.1542/peds.2012-0900Q
   LORD C, 1986, J AUTISM DEV DISORD, V16, P249, DOI 10.1007/BF01531658
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   McDougle CJ, 2000, CHILD ADOL PSYCH CL, V9, P201
   McGovern CW, 2005, J CHILD PSYCHOL PSYC, V46, P401, DOI 10.1111/j.1469-7610.2004.00361.x
   Mefford HC, 2012, NEW ENGL J MED, V366, P733, DOI 10.1056/NEJMra1114194
   Oosterling I, 2010, J AUTISM DEV DISORD, V40, P1447, DOI 10.1007/s10803-010-1004-0
   Rogers SJ, 2006, J AUTISM DEV DISORD, V36, P1007, DOI 10.1007/s10803-006-0142-x
   Rogers SJ, 2012, J AM ACAD CHILD PSY, V51, P1052, DOI 10.1016/j.jaac.2012.08.003
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   Scahill L, 2013, J AUTISM DEV DISORD, V43, P739, DOI 10.1007/s10803-012-1689-3
   Schreibman L., 2007, SCI FICTION AUTISM
   STAHMER AC, 1995, J AUTISM DEV DISORD, V25, P123, DOI 10.1007/BF02178500
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   State MW, 2012, SCIENCE, V337, P1301, DOI 10.1126/science.1224989
   Vernon TW, 2012, J AUTISM DEV DISORD, V42, P2702, DOI 10.1007/s10803-012-1535-7
   Volden J, 2007, J AUTISM DEV DISORD, V37, P1139, DOI 10.1007/s10803-006-0256-1
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Zarembo A., 2011, LOS ANGELES TIMES
NR 40
TC 0
Z9 0
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2013
VL 1304
BP 70
EP 76
DI 10.1111/nyas.12311
PG 7
WC Clinical Neurology; Pediatrics; Psychology
SC Neurosciences & Neurology; Pediatrics; Psychology
GA BA2LC
UT WOS:000333582200005
PM 24279894
ER

PT J
AU He, ZX
   O'Roak, B
   Smith, J
   Wang, G
   Hooker, S
   Santos-Cortez, R
   Li, B
   Kan, MY
   Krumm, N
   Nickerson, D
   Shendure, J
   Eichler, E
   Leal, S
AF He, Zongxiao
   O'Roak, Brian
   Smith, Joshua
   Wang, Gao
   Hooker, Stanley
   Santos-Cortez, Regie
   Li, Biao
   Kan, Mengyuan
   Krumm, Nik
   Nickerson, Deborah
   Shendure, Jay
   Eichler, Evan
   Leal, Suzanne
TI Rare Variant Extensions of the Transmission Disequilibrium Test:
   Application to Autism Exome Sequence Data
SO HUMAN HEREDITY
LA English
DT Meeting Abstract
CT 42nd European Mathematical Genetics Meeting (EMGM)
CY APR 01-02, 2014
CL Cologne, GERMANY
C1 [He, Zongxiao; Wang, Gao; Hooker, Stanley; Santos-Cortez, Regie; Li, Biao; Kan, Mengyuan; Leal, Suzanne] Baylor Coll Med, Dept Mol & Human Genet, Ctr Stat Genet, Houston, TX 77030 USA.
   [O'Roak, Brian; Smith, Joshua; Krumm, Nik; Nickerson, Deborah; Shendure, Jay; Eichler, Evan] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA USA.
EM suzannemleal@gmail.com
NR 0
TC 0
Z9 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0001-5652
EI 1423-0062
J9 HUM HERED
JI Hum. Hered.
PY 2013
VL 76
IS 2
BP 92
EP 92
PG 1
WC Genetics & Heredity
SC Genetics & Heredity
GA AD6BD
UT WOS:000333337100022
ER

PT J
AU Ionita-Laza, I
   Capanu, M
   De Rubeis, S
   McCallum, K
   Buxbaum, J
AF Ionita-Laza, Iuliana
   Capanu, Marinela
   De Rubeis, Silvia
   McCallum, Kenneth
   Buxbaum, Joseph
TI Identification of Rare Causal Variants in Sequence-Based Studies:
   Methods and Applications to Gene VPS13B, Involved in Cohen Syndrome and
   Autism
SO HUMAN HEREDITY
LA English
DT Meeting Abstract
CT 42nd European Mathematical Genetics Meeting (EMGM)
CY APR 01-02, 2014
CL Cologne, GERMANY
C1 [Ionita-Laza, Iuliana; McCallum, Kenneth] Columbia Univ, New York, NY USA.
   [Capanu, Marinela] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
   [De Rubeis, Silvia; Buxbaum, Joseph] Mt Sinai Sch Med, New York, NY USA.
EM ii2135@columbia.edu
NR 0
TC 0
Z9 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0001-5652
EI 1423-0062
J9 HUM HERED
JI Hum. Hered.
PY 2013
VL 76
IS 2
BP 93
EP 93
PG 1
WC Genetics & Heredity
SC Genetics & Heredity
GA AD6BD
UT WOS:000333337100023
ER

PT J
AU Burns, TG
   King, TZ
   Spencer, KS
AF Burns, Thomas G.
   King, Tricia Z.
   Spencer, Katherine S.
TI Mullen Scales of Early Learning: The Utility in Assessing Children
   Diagnosed With Autism Spectrum Disorders, Cerebral Palsy, and Epilepsy
SO APPLIED NEUROPSYCHOLOGY-CHILD
LA English
DT Article
DE autism; cerebral palsy; epilepsy; MSEL; pediatrics
ID WEIGHT PRETERM INFANTS; COGNITIVE FUNCTION; EARLY-INTERVENTION;
   YOUNG-CHILDREN; PROFILE; PERFORMANCE; LIMITATIONS; AGE
AB A group of 47 patients diagnosed with neurodevelopmental disorders were compared to 47 age-, gender-, and racially matched typically developing children to examine the frequency of impairment across domains of the Mullen Scales of Early Learning (MSEL). The MSEL is a comprehensive measure of cognitive functioning designed to assess infants and preschool children between the ages of birth to 68 months. In the neurodevelopmental group, the sample was composed of children 2 to 4 years of age who were diagnosed with autism spectrum disorders (ASD; n = 19), cerebral palsy (CP; n = 14), and epilepsy (EPI; n = 14). A sample of 47 matched controls, taken from the normative sample of the MSEL, was used as a comparison group. Each one of the clinical groups comprising the neurodevelopmental sample demonstrated statistically significant delays across domains relative to the respective matched control group (p < .001). Children failed to demonstrate a "signature" profile for a diagnosis of ASD, CP, or EPI. The clinical sensitivity of the MSEL and the need for obtaining specific intervention services for children diagnosed with these conditions are presented. Finally, these results are discussed within the context of the clinical sensitivity of the MSEL in working with these clinical populations.
C1 [Burns, Thomas G.; Spencer, Katherine S.] Childrens Healthcare Atlanta, Dept Neuropsychol, Neurosci Div, Atlanta, GA 30342 USA.
   [Burns, Thomas G.] Emory Univ, Sch Med, Atlanta, GA USA.
   [King, Tricia Z.] Georgia State Univ, Dept Psychol, Atlanta, GA 30303 USA.
RP Burns, TG (reprint author), Childrens Healthcare Atlanta, Dept Neuropsychol, Neurosci Div, 1001 Johnson Ferry Rd, Atlanta, GA 30342 USA.
EM Thomas.burns@choa.org
FU Hellen Ingram Plummer Charitable Foundation; Friends Research Fund from
   Children's Healthcare of Atlanta [01061]
FX This study was supported partially by the Hellen Ingram Plummer
   Charitable Foundation and the Friends Research Fund from Children's
   Healthcare of Atlanta (01061).
CR Akshoomoff N, 2006, CHILD NEUROPSYCHOL, V12, P269, DOI 10.1080/09297040500473714
   ALDENKAMP AP, 1993, NEUROLOGY, V43, P41
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Bassan H, 2007, PEDIATRICS, V120, P785, DOI 10.1542/peds.2007-0211
   Beckung E, 2002, DEV MED CHILD NEUROL, V44, P309
   BENNETT FC, 1991, PEDIATR CLIN N AM, V38, P1513
   BROOKSGUNN J, 1992, J PEDIATR-US, V120, P350, DOI 10.1016/S0022-3476(05)80896-0
   Mayes Susan Dickerson, 2006, J Atten Disord, V9, P486, DOI 10.1177/1087054705283616
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Donders J, 2008, J INT NEUROPSYCH SOC, V14, P651, DOI 10.1017/S1355617708080752
   Dumont R, 2000, J PSYCHOEDUC ASSESS, V18, P381, DOI 10.1177/073428290001800409
   Glascoe F P, 2000, Pediatr Rev, V21, P272, DOI 10.1542/pir.21-8-272
   Gosselin J, 2002, DEV MED CHILD NEUROL, V44, P323
   Hadders-Algra M, 2010, DEV MED CHILD NEUROL, V52, P87, DOI 10.1111/j.1469-8749.2009.03305.x
   Humphrey A, 2004, EUR CHILD ADOLES PSY, V13, P159, DOI 10.1007/s00787-004-0383-1
   Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
   Krakowiak P, 2008, J SLEEP RES, V17, P197, DOI 10.1111/j.1365-2869.2008.00650.x
   Lord C, 2004, J CHILD PSYCHOL PSYC, V45, P936, DOI 10.1111/j.1469-7610.2004.t01-1-00287.x
   Malhi P., 1999, INDIAN PEDIATR, V36, P569
   McConachie H, 2005, J AUTISM DEV DISORD, V35, P167, DOI 10.1007/s10803-005-1995-0
   McManus Beth M, 2007, Pediatr Phys Ther, V19, P275, DOI 10.1097/PEP.0b013e3181575190
   Mervis CB, 2000, BRAIN COGNITION, V44, P604, DOI 10.1006/brcg.2000.1232
   Morgan AM, 1996, PEDIATRICS, V98, P692
   Mullen E, 1995, MULLEN SCALES EARLY
   MURPHY CC, 1995, EPILEPSIA, V36, P866, DOI 10.1111/j.1528-1157.1995.tb01629.x
   National Research Council, 2001, ED CHILDR AUT
   Noreau L, 2010, ARCH PHYS MED REHAB, V91, P44
   O'Leary SD, 2006, CHILD NEUROPSYCHOL, V12, P173, DOI 10.1080/09297040500276844
   Richler J, 2007, J AUTISM DEV DISORD, V37, P73, DOI 10.1007/s10803-006-0332-6
   Ropper A. H., 2005, ADAMS VICTORS PRINCI
   Tabachnick B., 2001, USING MULTIVARIATE S
   Taylor J, 2010, EPILEPSIA, V51, P48, DOI 10.1111/j.1528-1167.2009.02195.x
   Van Naarden Braun K., 2007, MMWR-MORBID MORTAL W, V56, P1
   Wallace SJ, 2001, DEV MED CHILD NEUROL, V43, P713, DOI 10.1017/S0012162201001281
   Webster-Stratton C, 2010, PSYCHOL SCHOOLS, V47, P36, DOI 10.1002/pits.20450
   Westerveld M., 2010, PEDIAT NEUROPSYCHOLO, P71
   Wolf MJ, 2002, ACTA PAEDIATR, V91, P930, DOI 10.1080/080352502760148667
   Yeargin-Allsopp M., 2007, MMWR-MORBID MORTAL W, V56, P12
NR 39
TC 1
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 2162-2965
EI 2162-2973
J9 APPL NEUROPSYCH-CHIL
JI Appl. Neuropsychol.-Child
PY 2013
VL 2
IS 1
BP 33
EP 42
DI 10.1080/21622965.2012.682852
PG 10
WC Clinical Neurology; Psychology
SC Neurosciences & Neurology; Psychology
GA AD0SV
UT WOS:000332945300006
PM 23427775
ER

PT J
AU Shaheen, S
AF Shaheen, Sandra
TI Motor Assessment in Pediatric Neuropsychology: Relationships to
   Executive Function
SO APPLIED NEUROPSYCHOLOGY-CHILD
LA English
DT Article
DE action sequences; dyspraxia; executive control; motor assessment; soft
   neurological signs
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
   DISORDER; NORMAL CHILDREN; CEREBELLUM; AUTISM; COORDINATION; MOVEMENT;
   ADHD; INHIBITION; IMPAIRMENT
AB Executive function often refers to control behaviors such as "initiating," "sustaining," "inhibiting," and "switching." These mechanisms contribute to regulation of thinking and emotion but can be observed most clearly in the motor system. Neuropsychology has been influenced by "top-down" models of cognitive control that emerged from information-processing theories of cognition. In fact, neural models provide evidence that control processes are highly interactive within the cortico-striatal-cerebellar circuits. Cognition unfolds in response to motor-driven adaptation, and evidence exists for similar firing of brain cells and circuits during "imagined action" as in actual motor behavior. The motor system develops early and yet is not routinely assessed in neuropsychological evaluation of children with neurodevelopmental disorders. This article reviews some of the approaches to motor assessment that have sensitivity to neurodevelopmental disorders, and advocates for inclusion of motor assessment, particularly in evaluating control processes independent of culture, language, and other confounders.
C1 [Shaheen, Sandra] Boston Childrens Hosp, Dept Psychol, Boston, MA USA.
   [Shaheen, Sandra] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
RP Shaheen, S (reprint author), 319 Longwood Ave, Boston, MA 02115 USA.
EM longwoodneuro@earthlink.net
CR Alvarez JA, 2006, NEUROPSYCHOL REV, V16, P17, DOI 10.1007/s11065-006-9002-x
   Andrup G., 2008, NUBU 4 16 NEVROMOTOR
   Baron IS, 2004, NEUROPSYCHOLOGICAL E
   Bellebaum C, 2007, CEREBELLUM, V6, P184, DOI 10.1080/14734220601169707
   Berquin PC, 1998, NEUROLOGY, V50, P1087
   Berthier NE, 2010, INFANT BEHAV DEV, V33, P555, DOI 10.1016/j.infbeh.2010.07.007
   Birkett EE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042820
   Byers-Heinlein K, 2010, PSYCHOL SCI, V21, P343, DOI 10.1177/0956797609360758
   Castellanos F. X., 2001, STIMULANT DRUGS ADHD, P243
   Castellanos FX, 2006, TRENDS COGN SCI, V10, P117, DOI 10.1016/j.tics.2006.01.011
   Cisak P., 2010, ANNU REV NEUROSCI, V33, P269
   Decety J, 1996, COGNITIVE BRAIN RES, V3, P87, DOI 10.1016/0926-6410(95)00033-X
   Denckla M. B., 1994, FRAMES REFERENCE ASS, P117
   Denckla M. B., 1997, DEV PREFRONTAL CORTE, P283
   DENCKLA MB, 1985, PSYCHOPHARMACOL BULL, V21, P773
   DENCKLA MB, 1973, DEV MED CHILD NEUROL, V15, P635
   DENCKLA MB, 1992, HDB DEV NEUROPSYCHOL, V6, P455
   DENCKLA MB, 1974, DEV MED CHILD NEUROL, V16, P729
   Diamond A, 2011, SCIENCE, V333, P959, DOI 10.1126/science.1204529
   Diamond A, 2000, CHILD DEV, V71, P44, DOI 10.1111/1467-8624.00117
   Diamond A, 2007, SCIENCE, V318, P1387, DOI 10.1126/science.1151148
   Efstratopoulou M, 2012, RES DEV DISABIL, V33, P196, DOI 10.1016/j.ridd.2011.08.033
   EIMAS PD, 1971, SCIENCE, V171, P303, DOI 10.1126/science.171.3968.303
   Falck-Ytter T, 2006, NAT NEUROSCI, V9, P878, DOI 10.1038/nn1729
   Gershon RC, 2010, LANCET NEUROL, V9, P138, DOI 10.1016/S1474-4422(09)70335-7
   Giedd JN, 2001, ANN NY ACAD SCI, V931, P33
   Guillot A., 2012, FRONT HUM NEUROSCI, V6, P1
   Halperin JM, 2013, J ATTEN DISORD, V17, P711, DOI 10.1177/1087054711435681
   Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd
   Holm L, 2013, J EXP PSYCHOL HUMAN, V39, P365, DOI 10.1037/a0029142
   Horton Jr A. M., 1997, NEUROPSYCHOLOGY HDB, P221
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Korkman M., 2007, NEPSY 2 EDITION NEPS
   Koziol L., 2011, SUBCORTICAL STRUCTUR
   Koziol LF, 2012, CEREBELLUM, V11, P505, DOI 10.1007/s12311-011-0321-y
   Larson JCG, 2007, DEV NEUROPSYCHOL, V32, P543
   Lezak MD, 2012, NEUROPSYCHOLOGICAL A, V5th
   MacNeil LK, 2012, NEUROPSYCHOLOGY, V26, P165, DOI 10.1037/a0026955
   Mahone EM, 2006, J INT NEUROPSYCH SOC, V12, P622, DOI 10.1017/S1355617706060814
   MELTZOFF AN, 1977, SCIENCE, V198, P75, DOI 10.1126/science.198.4312.75
   Montessori M., 1986, DISCOVERY CHILD
   Mostofsky SH, 2007, BRAIN, V130, P2117, DOI 10.1093/brain/awm129
   Mostofsky SH, 2003, PERCEPT MOTOR SKILL, V97, P1315, DOI 10.2466/PMS.97.8.1315-1331
   Mostofsky SH, 1998, J CHILD NEUROL, V13, P434
   Nayate A, 2005, BRAIN RES BULL, V67, P327, DOI 10.1016/j.brainresbull.2005.07.011
   Njiokiktjien C., 2010, BRAIN LESION LOCALIZ, P157
   Nussbaum N. L., 2008, HDB CLIN CHILD NEURO, P247
   Pasini A, 2012, ACTA PAEDIATR, V101, pE15, DOI 10.1111/j.1651-2227.2011.02436.x
   Pezzulo G, 2011, MIND LANG, V26, P78, DOI 10.1111/j.1468-0017.2010.01411.x
   Poore M. A., 2009, PERSPECT SPEECH SCI, V19, P44
   Rigoli D, 2012, ARCH CLIN NEUROPSYCH, V27, P766, DOI 10.1093/arclin/acs061
   Rivkin MJ, 2003, PEDIATR NEUROL, V28, P89, DOI 10.1016/S0887-8994(02)00492-7
   Roeder MB, 2008, CHILD NEUROPSYCHOL, V14, P249, DOI 10.1080/09297040701370016
   Rubia K, 2003, J ABNORM CHILD PSYCH, V31, P301, DOI 10.1023/A:1023233630774
   RUTTER M, 1976, PSYCHOL MED, V6, P313
   Sanders Richard D, 2010, Psychiatry (Edgmont), V7, P38
   Schmahmann JD, 2004, J NEUROPSYCH CLIN N, V16, P367, DOI 10.1176/appi.neuropsych.16.3.367
   Schmahmann JD, 1997, INT REV NEUROBIOL, V41, P31
   Semrud-Clickman M., 2009, CHILD NEUROPSYCHOLOG
   Skirbekk B, 2012, PSYCHIAT RES, V198, P135, DOI 10.1016/j.psychres.2011.12.008
   Strauss E., 2006, COMPENDIUM NEUROPSYC
   Stray LL, 2009, BEHAV BRAIN FUNCT, V5, DOI 10.1186/1744-9081-5-21
   Sutera S., 2007, J AUTISM DEV DISORD, V37, P89
   Udal AH, 2009, BEHAV BRAIN FUNCT, V5, DOI 10.1186/1744-9081-5-47
   Venetsanou F, 2011, RES DEV DISABIL, V32, P1, DOI 10.1016/j.ridd.2010.09.006
   Waber DP, 2000, DEV NEUROPSYCHOL, V17, P181, DOI 10.1207/S15326942DN1702_03
   WOLFF PH, 1973, SEMIN PSYCHIAT, V5, P105
NR 67
TC 2
Z9 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 2162-2965
EI 2162-2973
J9 APPL NEUROPSYCH-CHIL
JI Appl. Neuropsychol.-Child
PY 2013
VL 2
IS 2
SI SI
BP 116
EP 124
DI 10.1080/21622965.2013.792668
PG 9
WC Clinical Neurology; Psychology
SC Neurosciences & Neurology; Psychology
GA AD0TF
UT WOS:000332946300006
PM 23745952
ER

PT J
AU Isquith, PK
   Roth, RM
   Gioia, G
AF Isquith, Peter K.
   Roth, Robert M.
   Gioia, Gerard
TI Contribution of Rating Scales to the Assessment of Executive Functions
SO APPLIED NEUROPSYCHOLOGY-CHILD
LA English
DT Article
DE ecological validity; executive function; measurement; psychometric;
   rating scales
ID TRAUMATIC BRAIN-INJURY; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
   DEFICIT HYPERACTIVITY DISORDER; PERFORMANCE-BASED MEASURES; AUTISM
   SPECTRUM DISORDERS; WORKING-MEMORY; NEUROPSYCHOLOGICAL ASSESSMENT;
   FUNCTION IMPAIRMENTS; ECOLOGICAL VALIDITY; CORTICAL THICKNESS
AB Executive functions play a vital role in the everyday functioning of healthy individuals across the lifespan and have been implicated in a wide variety of clinical conditions. Historically, the assessment of executive functions in clinical and research settings relied on performance-based measures. A number of authors have argued, however, that such measures have limited ecological validity. In response to this limitation of performance-based measures, several rating scales have been developed that seek to gauge a person's or their knowledgeable informant's (e. g., parent or teacher) subjective view of executive functioning in everyday life. In this article we review evidence supporting the use of rating scales of executive function including profiles in clinical populations, biological correlates, relationships to relevant outcome measures such as academic performance, and correlations with performance-based measures. We conclude that performance-based and rating scale measures provide complementary information with respect to a child's executive functions, offering a more comprehension view than either approach alone.
C1 [Isquith, Peter K.; Roth, Robert M.] Geisel Sch Med Dartmouth, Dept Psychiat, Neuropsychol Program, Lebanon, NH 03756 USA.
   [Gioia, Gerard] Childrens Natl Med Ctr, Div Neuropsychol, Washington, DC 20010 USA.
RP Isquith, PK (reprint author), Geisel Sch Med Dartmouth, Dept Psychiat, Neuropsychol Program, One Med Ctr Dr, Lebanon, NH 03756 USA.
EM peter@qpsych.com
CR Anderson VA, 2002, CHILD NEUROPSYCHOL, V8, P231
   Anderson V, 2005, J INT NEUROPSYCH SOC, V11, P817, DOI 10.1017/S1355617705051052
   Anderson V., 2008, EXECUTIVE FUNCTIONS, P123
   Antshel KM, 2005, PSYCHIAT RES-NEUROIM, V138, P235, DOI 10.1016/j.pscychresns.2005.02.003
   Bodnar LE, 2007, CHILD NEUROPSYCHOL, V13, P345, DOI 10.1080/09297040600899867
   Brown TM, 2008, CHILD NEUROPSYCHOL, V14, P118, DOI 10.1080/09297040601147605
   Burgess P, 1997, METHODOLOGY FRONTAL, P81
   Chapman LA, 2010, REHABIL PSYCHOL, V55, P48, DOI 10.1037/a0018418
   Christ SE, 2010, NEUROPSYCHOLOGY, V24, P590, DOI 10.1037/a0019176
   Clark CAC, 2010, DEV PSYCHOL, V46, P1176, DOI 10.1037/a0019672
   Conklin HM, 2008, BRAIN INJURY, V22, P847, DOI 10.1080/02699050802403565
   Culberton W. C., 2000, TOWER LONDON DX
   Delis DC, 2001, DELIS KAPLAN EXECUTI
   Diamond A., 1988, THOUGHT LANGUAGE, P337
   Donders J, 2010, J NEUROPSYCHOL, V4, P197, DOI 10.1348/174866409X478970
   Ferrier D., 1886, FUNCTIONS BRAIN
   Franzen MD, 1996, ECOLOGICAL VALIDITY, P91
   Garlinghouse MA, 2010, SCHIZOPHR RES, V120, P71, DOI 10.1016/j.schres.2010.02.1067
   Ghassabian A, 2013, J CHILD PSYCHOL PSYC, V54, P96, DOI 10.1111/j.1469-7610.2012.02590.x
   Gioia GA, 2010, J HEAD TRAUMA REHAB, V25, P433, DOI 10.1097/HTR.0b013e3181fbc272
   Gioia GA, 2000, BRIEF BEHAV RATING I
   Gioia GA, 2004, DEV NEUROPSYCHOL, V25, P135, DOI 10.1207/s15326942dn2501&2_8
   Gioia GA, 2002, CHILD NEUROPSYCHOL, V8, P121
   Goldberg E, 2000, J CLIN EXP NEUROPSYC, V22, P56, DOI 10.1076/1380-3395(200002)22:1;1-8;FT056
   Grace J, 2002, FRONTAL SYSTEMS BEHA
   Holmes Bernstein J, 2007, EXECUTIVE FUNCTION E, P39
   Holmes-Bernstein J., 1990, NEUROPSYCHOLOGY, P311
   Isquith PK, 2004, DEV NEUROPSYCHOL, V26, P403, DOI 10.1207/s15326942dn2601_3
   Jarratt KP, 2005, APPL NEUROPSYCHOL, V12, P83, DOI 10.1207/s15324826an1202_4
   Kaplan E., 1988, CLIN NEUROPSYCHOLOGY, P129
   Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
   Kenworthy L, 2009, CHILD NEUROPSYCHOL, V15, P425, DOI 10.1080/09297040802646983
   Kenworthy LE, 2005, DEV NEUROPSYCHOL, V28, P809, DOI 10.1207/s15326942dn2803_4
   Kesler SR, 2011, ARCH NEUROL-CHICAGO, V68, P1447, DOI 10.1001/archneurol.2011.245
   Locascio G, 2010, J LEARN DISABIL-US, V43, P441, DOI 10.1177/0022219409355476
   MacAllister WS, 2012, CHILD NEUROPSYCHOL, V18, P404, DOI 10.1080/09297049.2011.613812
   Mahone EM, 2009, J INT NEUROPSYCH SOC, V15, P31, DOI 10.1017/S1355617708090164
   Mahone EM, 2002, ARCH CLIN NEUROPSYCH, V17, P643, DOI 10.1016/S0887-6177(01)00168-8
   Mahone EM, 2007, CLIN NEUROPSYCHOL, V21, P569, DOI 10.1080/13854040600762724
   Maillard-Wermelinger A, 2009, DEV NEUROREHABIL, V12, P330, DOI [10.3109/17518420903087251, 10.1080/17518420903087251]
   Mangeot S, 2002, CHILD NEUROPSYCHOL, V8, P271, DOI 10.1076/chin.8.4.271.13503
   Mares D, 2007, CAN J PSYCHIAT, V52, P527
   McAuley T, 2010, J INT NEUROPSYCH SOC, V16, P495, DOI 10.1017/S1355617710000093
   McCandless Stephen, 2007, J Atten Disord, V10, P381, DOI 10.1177/1087054706292115
   McCauley JL, 2010, J CHILD PSYCHOL PSYC, V51, P84, DOI 10.1111/j.1469-7610.2009.02134.x
   McDonald B. C., BRAIN BEHAV IN PRESS
   Merkley TL, 2008, J NEUROTRAUM, V25, P1343, DOI 10.1089/neu.2008.0615
   Nadebaum C, 2007, DEV NEUROPSYCHOL, V32, P703
   Parrish J, 2007, DEV MED CHILD NEUROL, V49, P412
   Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
   Reddy LA, 2011, SCHOOL PSYCHOL QUART, V26, P45, DOI 10.1037/a0022585
   Reynolds C. R., 1992, BEHAV ASSESSMENT SYS
   Rotenberg-Shpigelman S., 2008, ISRAELI J OCCUPATION, V17, P77
   Sbordone R. J., 1996, ECOLOGICAL VALIDITY, P15
   Silver CH, 2000, J HEAD TRAUMA REHAB, V15, P973
   Slick DJ, 2006, CHILD NEUROPSYCHOL, V12, P181, DOI 10.1080/09297040600611320
   STUSS DT, 1984, PSYCHOL BULL, V95, P3, DOI 10.1037//0033-2909.95.1.3
   Stuss DT, 1986, FRONTAL LOBES
   Sullivan Jeremy R, 2007, J Atten Disord, V11, P398, DOI 10.1177/1087054707299399
   Toplak ME, 2009, CHILD NEUROPSYCHOL, V15, P53, DOI 10.1080/09297040802070929
   Turkstra Lyn S., 2005, Seminars in Speech and Language, V26, P215, DOI 10.1055/s-2005-922101
   Vriezen ER, 2002, CHILD NEUROPSYCHOL, V8, P296, DOI 10.1076/chin.8.4.296.13505
   Waber DP, 2006, DEV NEUROPSYCHOL, V29, P459, DOI 10.1207/s15326942dn2903_5
   WELSH MC, 1988, DEV NEUROPSYCHOL, V4, P199
   WELSH MC, 1991, DEV NEUROPSYCHOL, V7, P131
   Wilde EA, 2012, INT J DEV NEUROSCI, V30, P267, DOI 10.1016/j.ijdevneu.2012.01.003
   Wilson B.A., 1996, BEHAV ASSESSMENT DYS
   Wozniak JR, 2007, ARCH CLIN NEUROPSYCH, V22, P555, DOI 10.1016/j.acn.2007.03.004
   Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103
NR 69
TC 10
Z9 10
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 2162-2965
EI 2162-2973
J9 APPL NEUROPSYCH-CHIL
JI Appl. Neuropsychol.-Child
PY 2013
VL 2
IS 2
SI SI
BP 125
EP 132
DI 10.1080/21622965.2013.748389
PG 8
WC Clinical Neurology; Psychology
SC Neurosciences & Neurology; Psychology
GA AD0TF
UT WOS:000332946300007
PM 23442015
ER

PT J
AU Sireteanu, A
   Volosciuc, M
   Gramescu, M
   Gorduza, EV
   Vulpoi, C
   Frunza, I
   Rusu, C
AF Sireteanu, A.
   Volosciuc, M.
   Gramescu, M.
   Gorduza, E., V
   Vulpoi, C.
   Frunza, I
   Rusu, C.
TI DICENTRIC CHROMOSOME 14;18 PLUS TWO ADDITIONAL CNVs IN A GIRL WITH
   MICROFORM HOLOPROSENCEPHALY AND TURNER STIGMATA
SO BALKAN JOURNAL OF MEDICAL GENETICS
LA English
DT Article
DE 18p-syndrome; Holoprosencephaly (HPE); Single nucleotide polymorphism
   (SNP) array; 16p11.2 duplication
ID MOLECULAR CHARACTERIZATION; 16P11.2; 18P; REARRANGEMENTS; ASSOCIATION;
   DELETION; AUTISM
AB We report a 20-year-old female with features evocative of Turner syndrome (short stature, broad trunk, mild webbed neck), dysmorphic face, minor features of holo-prosencephaly (HPE), small hands and feet, excessive hair growth on anterior trunk and intellectual disability. Cytogenetic analysis identified a pseudodicentric 14;18 chromosome. Genome wide single nucleotide polymorphism (SNP) array showed a terminal deletion of approximately 10.24 Mb, from 18p11.32 to 18p11.22, flanked by a duplication of approximately 1.15 Mb, from 18p11.22 to 18p11.21. In addition, the SNP array revealed a duplication of 516 kb in 16p11.2. We correlated the patient's clinical findings with the features mentioned in the literature for these copy number variations. This case study shows the importance of microarray analysis in the detection of cryptic chromosomal rearrangements in patients with intellectual disability and multiple congenital anomalies.
C1 [Sireteanu, A.; Gorduza, E., V; Rusu, C.] Grigore T Popa Univ Med & Pharm, Dept Med Genet, Iasi 700115, Romania.
   [Volosciuc, M.] Sf Maria Childrens Hosp, Ctr Med Genet, Iasi, Romania.
   [Vulpoi, C.] Grigore T Popa Univ Med & Pharm, Dept Endocrinol, Iasi 700115, Romania.
   [Frunza, I] CF Hosp, Dept Neurol, Iasi, Romania.
RP Rusu, C (reprint author), Grigore T Popa Univ Med & Pharm, Dept Med Genet, Str Univ 16, Iasi 700115, Romania.
EM abcrusu@gmail.com
CR Bendavid C, 2009, HUM MUTAT, V30, P1175, DOI 10.1002/humu.21016
   Brenk CH, 2007, EUR J HUM GENET, V15, P35, DOI 10.1038/sj.ejhg.5201718
   de Grouchy J, 1963, CR HEBD ACAD SCI, V256, P1028
   Digilio MC, 2000, AM J MED GENET, V94, P198, DOI 10.1002/1096-8628(20000918)94:3<198::AID-AJMG4>3.0.CO;2-9
   Fernandez BA, 2010, J MED GENET, V47, P195, DOI 10.1136/jmg.2009.069369
   Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
   Kumar RA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004582
   Lemyre E, 2001, J MED GENET, V38, P76, DOI 10.1136/jmg.38.1.76
   Marical H, 2007, AM J MED GENET A, V143A, P2192, DOI 10.1002/ajmg.a.31881
   McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
   Ming JE, 2002, AM J HUM GENET, V71, P1017, DOI 10.1086/344412
   Portnoi MF, 2007, CLIN DYSMORPHOL, V16, P247, DOI 10.1097/MCD.0b013e328235a572
   Rosenfeld JA, 2013, GENET MED, V15, P478, DOI 10.1038/gim.2012.164
   Schaaf CP, 2011, EUR J HUM GENET, V19, P152, DOI 10.1038/ejhg.2010.168
   Schinzel A., 2001, CATALOGUE UNBALANCED
   Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
   SUMNER AT, 1972, EXP CELL RES, V75, P304, DOI 10.1016/0014-4827(72)90558-7
   Tsukahara M, 2001, AM J MED GENET, V99, P67, DOI 10.1002/1096-8628(20010215)99:1<67::AID-AJMG1118>3.0.CO;2-V
   Turleau C, 2008, ORPHANET J RARE DIS, V3, DOI 10.1186/1750-1172-3-4
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Wester U, 2006, AM J MED GENET A, V140A, P1164, DOI 10.1002/ajmg.a.31260
NR 21
TC 0
Z9 0
PU MACEDONIAN ACAD SCIENCES ARTS
PI SKOPJE
PA BULEVAR KRSTE MISIRKOV 2, P. O. B. 428, SKOPJE, 1000, MACEDONIA
SN 1311-0160
J9 BALK J MED GENET
JI Balk. J. Med. Gen.
PY 2013
VL 16
IS 2
BP 67
EP 72
DI 10.2478/bjmg-2013-0034
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA AD0RV
UT WOS:000332942700010
PM 24778566
ER

PT J
AU Nousen, EK
   Franco, JG
   Sullivan, EL
AF Nousen, Elizabeth K.
   Franco, Juliana G.
   Sullivan, Elinor L.
TI Unraveling the Mechanisms Responsible for the Comorbidity between
   Metabolic Syndrome and Mental Health Disorders
SO NEUROENDOCRINOLOGY
LA English
DT Article
DE Obesity; Metabolic syndrome Diabetes; Schizophrenia; Bipolar disorder;
   Depression
ID HEART-RATE-VARIABILITY; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
   CORTICOTROPIN-RELEASING-FACTOR; HIGH-FAT DIET; DEFICIT HYPERACTIVITY
   DISORDER; NUTRITION EXAMINATION SURVEY; AUTISM SPECTRUM DISORDER; TYPE-2
   DIABETES-MELLITUS; NIGHT EATING SYNDROME; BODY-MASS INDEX
AB The increased prevalence and high comorbidity of metabolic syndrome (MetS) and mental health disorders (MHDs) have prompted investigation into the potential contributing mechanisms. There is a bidirectional association between MetS and MHDs including schizophrenia, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological mechanisms that explain the high comorbidity between these two disorders. Inflammation is a state shared by both disorders, and it contributes to disruptions of neuroregulatory systems (including the serotonergic, dopaminergic, and neuropeptide Y systems) as well as dysregulation of the hypothalamic-pituitary-adrenal axis. MetS in pregnant women also exposes the developing fetal brain to inflammatory factors that predispose the offspring to MetS and psychopathologies. Due to the shared nature of these conditions, treatment should address aspects of both mental health and metabolic disorders. Additionally, interventions that can interrupt the transfer of increased risk of the disorders to the next generation need to be developed. (C) 2013 S. Karger AG, Basel
C1 [Nousen, Elizabeth K.; Franco, Juliana G.; Sullivan, Elinor L.] Oregon Natl Primate Res Ctr, Div Diabet Obes & Metab, Beaverton, OR USA.
   [Sullivan, Elinor L.] Univ Portland, Dept Biol, Portland, OR 97203 USA.
RP Sullivan, EL (reprint author), Univ Portland, 5000 N Willamette Blvd, Portland, OR 97203 USA.
EM sullivae@up.edu
FU Murdock Charitable Trust; Murdock College Research Program for Life
   Science [2011273:HVP]; Oregon Clinical and Translational Research
   Institute (OCTRI) [UL1TR000128]; National Center for Advancing
   Translational Sciences (NCATS) at the National Institutes of Health
   (NIH)
FX This publication was supported by the Murdock Charitable Trust, Murdock
   College Research Program for Life Science, grant No. 2011273:HVP and
   Oregon Clinical and Translational Research Institute (OCTRI), grant No.
   (UL1TR000128) from the National Center for Advancing Translational
   Sciences (NCATS) at the National Institutes of Health (NIH). The content
   is solely the responsibility of the authors and does not necessarily
   represent the official views of the NIH.
CR Aarts S, 2009, EUR J EPIDEMIOL, V24, P641, DOI 10.1007/s10654-009-9385-0
   Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Ahmed AT, 2011, ADV THER, V28, P389, DOI 10.1007/s12325-011-0015-3
   Al-Ayadhi Laila Y, 2005, Neurosciences (Riyadh), V10, P155
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alesci S, 2005, J CLIN ENDOCR METAB, V90, P2522, DOI 10.1210/jc.2004-1667
   Alfonsson S, 2012, OBES SURG, V22, P918, DOI 10.1007/s11695-011-0569-9
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Allison DB, 2009, AM J PREV MED, V36, P341, DOI 10.1016/j.amepre.2008.11.020
   Almandil NB, 2013, PEDIATR DRUGS, V15, P139, DOI 10.1007/s40272-013-0016-6
   ANDREWS N, 1994, EUR J PHARMACOL, V264, P259, DOI 10.1016/0014-2999(94)00473-0
   Appelhans BM, 2012, J ACAD NUTR DIET, V112, P693, DOI 10.1016/j.jand.2012.02.006
   Arborelius L, 1999, J ENDOCRINOL, V160, P1, DOI 10.1677/joe.0.1600001
   Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P840, DOI 10.1016/j.bbi.2010.09.002
   Assoumou HGN, 2010, REJUV RES, V13, P653, DOI 10.1089/rej.2010.1019
   Bailer UF, 2012, INT J EAT DISORDER, V45, P263, DOI 10.1002/eat.20937
   Bajaj Sarita, 2012, Indian J Endocrinol Metab, V16, P759, DOI 10.4103/2230-8210.100670
   Baldo BA, 2007, PSYCHOPHARMACOLOGY, V191, P439, DOI 10.1007/s00213-007-0741-z
   Basu S, 2011, OBESITY, V19, P476, DOI 10.1038/oby.2010.215
   Bauer S, 2007, NAT REV NEUROSCI, V8, P221, DOI 10.1038/nrn2054
   Beckers S, 2008, MOL GENET METAB, V95, P110, DOI 10.1016/j.ymgme.2008.06.008
   Bensenor IM, 2012, GEN HOSP PSYCHIAT, V34, P268, DOI 10.1016/j.genhosppsych.2011.12.010
   Bilbo SD, 2010, FASEB J, V24, P2104, DOI 10.1096/fj.09-144014
   Bisschop MI, 2004, J CLIN EPIDEMIOL, V57, P187, DOI 10.1016/j.jclinepi.2003.01.001
   BJORNTORP P, 1995, METABOLISM, V44, P21, DOI 10.1016/0026-0495(95)90315-1
   BLACK DW, 1992, AM J PSYCHIAT, V149, P227
   BLUNDELL JE, 1974, EUR J PHARMACOL, V28, P81, DOI 10.1016/0014-2999(74)90115-0
   BLUNDELL JE, 1975, J PHARM PHARMACOL, V27, P31
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
   Boyle JP, 2010, POPUL HEALTH METR, V8, DOI 10.1186/1478-7954-8-29
   Bremmer MA, 2008, J AFFECT DISORDERS, V106, P249, DOI 10.1016/j.jad.2007.07.002
   Brunoni AR, 2011, PROG NEURO-PSYCHOPH, V35, P96, DOI 10.1016/j.pnpbp.2010.09.010
   Buehler MR, 2011, MED HYPOTHESES, V76, P863, DOI 10.1016/j.mehy.2011.02.038
   Buss C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037758
   Byerly MS, 2009, AM J PHYSIOL-REG I, V296, pR1180, DOI 10.1152/ajpregu.90813.2008
   Caberlotto L, 1999, NEUROREPORT, V10, P1747, DOI 10.1097/00001756-199906030-00022
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251
   Carpiniello B, 2012, EAT WEIGHT DISORD-ST, V17, pE259, DOI 10.3275/8809
   Centers for Disease Control and Prevention, 2011, NAT DIAB FACT SHEET
   Cervenka S, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.40
   Challier JC, 2008, PLACENTA, V29, P274, DOI 10.1016/j.placenta.2007.12.010
   Champaneri S, 2010, CURR DIABETES REP, V10, P396, DOI 10.1007/s11892-010-0148-9
   Chen AY, 2010, OBESITY, V18, P210, DOI 10.1038/oby.2009.185
   Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9
   Cleator J, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2012.16
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Coppola V, 2004, NEUROREPORT, V15, P2665, DOI 10.1097/00001756-200412030-00022
   Cortese S, 2013, PEDIATRICS, V131, pE1731, DOI 10.1542/peds.2012-0540
   Coste SC, 2001, PEPTIDES, V22, P733, DOI 10.1016/S0196-9781(01)00386-2
   Czeglédi Edit, 2012, Psychiatr Hung, V27, P361
   Danner M, 2003, PSYCHOSOM MED, V65, P347, DOI 10.1097/01.PSY.0000041542.29808.01
   Das UN, 2001, NUTRITION, V17, P953, DOI 10.1016/S0899-9007(01)00672-4
   Dean B, 2012, CURR TOP MED CHEM, V12, P2375
   Deng T, 2013, CELL METAB, V17, P411, DOI 10.1016/j.cmet.2013.02.009
   Dentino AN, 1999, J AM GERIATR SOC, V47, P6
   Deuschle M, 2013, CURR OPIN PSYCHIATR, V26, P60, DOI 10.1097/YCO.0b013e32835a4206
   de Zwaan M, 2001, INT J OBESITY, V25, pS51, DOI 10.1038/sj/ijo/0801699
   Dixon JB, 2003, ARCH INTERN MED, V163, P2058, DOI 10.1001/archinte.163.17.2058
   Docet MF, 2012, EAT WEIGHT DISORD-ST, V17, pE132
   Donev Rossen, 2010, Atten Defic Hyperact Disord, V2, P257, DOI 10.1007/s12402-010-0038-7
   Duncan GE, 2004, DIABETES CARE, V27, P2438, DOI 10.2337/diacare.27.10.2438
   El-Ansary A, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-265
   Ellman LM, 2010, SCHIZOPHR RES, V121, P46, DOI 10.1016/j.schres.2010.05.014
   El-Tarras AE, 2012, MOL BIOL REP, V39, P11081, DOI 10.1007/s11033-012-2012-2
   Erhart M, 2012, EUR CHILD ADOLES PSY, V21, P39, DOI 10.1007/s00787-011-0230-0
   Ernst C, 2012, ARCH GEN PSYCHIAT, V69, P1238, DOI 10.1001/archgenpsychiatry.2012.660
   Faludi Gabor, 2012, Neuropsychopharmacol Hung, V14, P221
   Favalli G, 2012, J PSYCHIATR RES, V46, P1, DOI 10.1016/j.jpsychires.2011.09.022
   Felicio AC, 2010, PSYCHOPHARMACOLOGY, V211, P27, DOI 10.1007/s00213-010-1867-y
   Fillman SG, 2013, MOL PSYCHIATR, V18, P206, DOI 10.1038/mp.2012.110
   Flegal KM, 2012, JAMA-J AM MED ASSOC, V307, P491, DOI 10.1001/jama.2012.39
   Fleming J P, 2005, Eat Weight Disord, V10, pe10
   FOLTIN RW, 1989, APPETITE, V12, P145, DOI 10.1016/0195-6663(89)90103-7
   Fowler-Brown AG, 2012, OBESITY, V20, P1922, DOI 10.1038/oby.2011.311
   Fredriksson A, 2004, NEUROTOX RES, V6, P435
   Frias AE, 2011, ENDOCRINOLOGY, V152, P2456, DOI 10.1210/en.2010-1332
   Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x
   GEYER MA, 1976, BRAIN RES, V106, P257, DOI 10.1016/0006-8993(76)91024-6
   GHOSH MN, 1973, BRIT J PHARMACOL, V48, pP328
   Gibson EL, 2012, BEHAV PHARMACOL, V23, P442, DOI 10.1097/FBP.0b013e328357bd4e
   Goines PE, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-13
   Gong Y, 2012, CNS NEUROSCI THER, V18, P461, DOI 10.1111/j.1755-5949.2012.00324.x
   Gray J, 2006, DANCING TIMES, V96, P55
   Grilo CM, 2012, INT J EAT DISORDER, V45, P787, DOI 10.1002/eat.22011
   GRINKER JA, 1980, PHARMACOL BIOCHEM BE, V12, P265, DOI 10.1016/0091-3057(80)90367-6
   Grover S, 2013, NORD J PSYCHIAT
   Halfon N, 2013, ACAD PEDIATR, V13, P6, DOI 10.1016/j.acap.2012.10.007
   Halford JCG, 1996, PHYSIOL BEHAV, V60, P933, DOI 10.1016/0031-9384(96)00073-X
   Hall FS, 2003, NEUROPSYCHOPHARMACOL, V28, P1485, DOI 10.1038/sj.npp.1300192
   Hallden S, 2013, HEART, V99, P949, DOI 10.1136/heartjnl-2013-303634
   Hamlyn J, 2013, NEUROBIOL DIS, V53, P3, DOI 10.1016/j.nbd.2012.10.023
   Hasnain M, 2012, POSTGRAD MED, V124, P154, DOI 10.3810/pgm.2012.07.2577
   HEILIG M, 1989, PSYCHOPHARMACOLOGY, V98, P524, DOI 10.1007/BF00441953
   Heo M, 2006, INT J OBESITY, V30, P513, DOI 10.1038/sj.ijo.0803122
   HOFFMAN BJ, 1989, FEBS LETT, V247, P453, DOI 10.1016/0014-5793(89)81390-0
   Hori H, 2012, THESCIENTIFICWORLDJO, V2012
   Hotta K, 2009, J HUM GENET, V54, P727, DOI 10.1038/jhg.2009.106
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Hyman Susan L, 2012, Pediatrics, V130 Suppl 2, pS145, DOI 10.1542/peds.2012-0900L
   Ieda M., 2013, EUR ARCH PSYCHIAT CL
   JONES AP, 1990, PHYSIOL BEHAV, V47, P1107, DOI 10.1016/0031-9384(90)90359-C
   Jones A P, 1995, Brain Res Dev Brain Res, V88, P127
   Karlsson J, 2003, INT J OBESITY, V27, P617, DOI 10.1038/sj.ijo.0802272
   Kasen S, 2008, INT J OBESITY, V32, P558, DOI 10.1038/sj.ijo.0803736
   Kask A, 1998, NEUROREPORT, V9, P2713, DOI 10.1097/00001756-199808240-00005
   Kemp AH, 2013, INT J PSYCHOPHYSIOL, V89, P288, DOI 10.1016/j.ijpsycho.2013.06.018
   Kemp AH, 2010, BIOL PSYCHIAT, V67, P1067, DOI 10.1016/j.biopsych.2009.12.012
   KENNETT GA, 1988, PSYCHOPHARMACOLOGY, V96, P93, DOI 10.1007/BF02431539
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P617, DOI 10.1001/archpsyc.62.6.617
   Kinzl Johann F, 2012, Neuropsychiatr, V26, P159, DOI 10.1007/s40211-012-0036-4
   Kivimaki M, 2010, DIABETES CARE, V33, P1471, DOI 10.2337/dc09-2359
   Kiyohara Chikako, 2009, Environmental Health and Preventive Medicine, V14, P71, DOI 10.1007/s12199-008-0073-6
   Klinitzke G, 2013, J AFFECT DISORDERS, V145, P277, DOI 10.1016/j.jad.2012.07.010
   Knol MJ, 2009, DIABETOLOGIA, V52, P425, DOI 10.1007/s00125-008-1249-8
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178
   Koskinen T, 2009, DIABETIC MED, V26, P354, DOI 10.1111/j.1464-5491.2009.02686.x
   Krakowiak P, 2012, PEDIATRICS, V129, pE1121, DOI 10.1542/peds.2011-2583
   Kubistova A, 2012, PSYCHIAT DANUB, V24, pS153
   Kuromitsu J, 2001, Brain Res Gene Expr Patterns, V1, P17
   Lagace DC, 2007, AM J PSYCHIAT, V164, P205, DOI 10.1176/appi.ajp.164.2.205
   Lee K, 2011, J KOREAN ACAD NURS, V41, P788, DOI 10.4040/jkan.2011.41.6.788
   Lee MD, 1997, PSYCHOPHARMACOLOGY, V131, P264, DOI 10.1007/s002130050292
   Leonard H, 2006, ANN EPIDEMIOL, V16, P448, DOI 10.1016/j.annepidem.2005.05.002
   Li WJ, 2013, AM J MED GENET B, V162, P538, DOI 10.1002/ajmg.b.32183
   Licht CMM, 2010, BIOL PSYCHIAT, V68, P861, DOI 10.1016/j.biopsych.2010.06.032
   Lopez-Pantoja JL, 2012, ACTAS ESP PSIQUIATRI, V40, P266
   <IT>Centers for Disease Control and Prevention (CDC)</IT>, 2010, BEH RISK FACT SURV S
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Madan I, 2010, J PERINAT MED, V38, P275, DOI 10.1515/JPM.2010.001
   Maddi SR, 2001, OBES SURG, V11, P680, DOI 10.1381/09608920160558605
   Maddi SR, 1997, OBES SURG, V7, P397, DOI 10.1381/096089297765555377
   Mangge H, 2013, OBESITY SILVER SPRIN
   Mansur RB, 2013, PROG NEURO-PSYCHOPH, V43, P66, DOI 10.1016/j.pnpbp.2012.12.004
   MCGUIRK J, 1991, BEHAV PHARMACOL, V2, P113
   McKernan DP, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.37
   McLaren L, 2008, SOC PSYCH PSYCH EPID, V43, P63, DOI 10.1007/s00127-007-0269-x
   Mezuk B, 2013, HEALTH PSYCHOL, V32, P254, DOI 10.1037/a0029014
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Milano W, 2012, J PHARM PHARMACOL, V64, P2, DOI 10.1111/j.2042-7158.2011.01353.x
   Min KB, 2008, PACE, V31, P584, DOI 10.1111/j.1540-8159.2008.01045.x
   Monje ML, 2003, SCIENCE, V302, P1760, DOI 10.1126/science.1088417
   Morales-Medina JC, 2010, BRAIN RES, V1314, P194, DOI 10.1016/j.brainres.2009.09.077
   Morrison CD, 2007, NUTR REV, V65, P517, DOI 10.1301/nr.2007.dec.517-534
   Muller MB, 2004, NEUROENDOCRINOLOGY, V79, P1, DOI 10.1159/000076041
   Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
   Narayanan NS, 2010, FRONT NEUROENDOCRIN, V31, P104, DOI 10.1016/j.yfrne.2009.10.004
   Nawa H, 2012, METHODS MOL BIOL, V829, P445, DOI 10.1007/978-1-61779-458-2_28
   NEMEROFF CB, 1988, ARCH GEN PSYCHIAT, V45, P577
   NEMEROFF CB, 1984, SCIENCE, V226, P1342, DOI 10.1126/science.6334362
   Nemeroff CB, 2012, NAT REV CARDIOL, V9, P526, DOI 10.1038/nrcardio.2012.91
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Nichols GA, 2003, DIABETES CARE, V26, P744, DOI 10.2337/diacare.26.3.744
   Nonogaki K, 1998, NAT MED, V4, P1152, DOI 10.1038/2647
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   Oades RD, 1998, PSYCHIAT RES, V80, P177, DOI 10.1016/S0165-1781(98)00064-X
   Oades RD, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-48
   O'Connor PJ, 2009, ANN FAM MED, V7, P328, DOI 10.1370/afm.964
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Oh KS, 2003, YONSEI MED J, V44, P787
   Oken E, 2003, OBES RES, V11, P496, DOI 10.1038/oby.2003.69
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Pagoto SL, 2009, OBESITY, V17, P539, DOI 10.1038/oby.2008.587
   Pan A, 2010, ARCH INTERN MED, V170, P1884, DOI 10.1001/archinternmed.2010.356
   Papageorgiou GM, 2002, OBES SURG, V12, P534, DOI 10.1381/096089202762252307
   Pasqualetti M, 1999, NEUROSCIENCE, V92, P601, DOI 10.1016/S0306-4522(99)00011-1
   Pattarachotanant N, 2010, GENET MOL RES, V9, P565, DOI 10.4238/vol9-1gmr757
   PAZOS A, 1985, BRAIN RES, V346, P205, DOI 10.1016/0006-8993(85)90856-X
   Peleg-Raibstein D, 2012, BEHAV BRAIN RES, V233, P398, DOI 10.1016/j.bbr.2012.05.027
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(03)01811-5
   Peterhansel C, 2013, OBES REV, V14, P369, DOI 10.1111/obr.12014
   Petry NM, 2008, PSYCHOSOM MED, V70, P288, DOI 10.1097/PSY.0b013e3181651651
   Peyrot M, 1997, DIABETES CARE, V20, P585, DOI 10.2337/diacare.20.4.585
   Pickering RP, 2011, J CLIN PSYCHIAT, V72, P1494, DOI 10.4088/JCP.10m06077gry
   PLAGEMANN A, 1992, EXP CLIN ENDOCRINOL, V99, P91
   Pouwer F, 2003, DIABETOLOGIA, V46, P892, DOI 10.1007/s00125-003-1124-6
   Prasad A, 1996, PHYSIOL BEHAV, V60, P1039
   Raadsheer PC, 1994, NEUROENDOCRINOLOGY, V60, P436
   Radaelli T, 2003, DIABETES, V52, P2951, DOI 10.2337/diabetes.52.12.2951
   Raghanti MA, 2013, AM J PRIMATOL, V75, P415, DOI 10.1002/ajp.22082
   Ray GT, 2009, MED CARE, V47, P105, DOI 10.1097/MLR.0b013e31817e18c0
   Raygada M, 1998, J NUTR, V128, P2505
   Rimmer JH, 2010, J INTELL DISABIL RES, V54, P787, DOI 10.1111/j.1365-2788.2010.01305.x
   Roberts KA, 2011, PLACENTA, V32, P247, DOI 10.1016/j.placenta.2010.12.023
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.08022204
   Robinson M, 2013, J DEV ORIG HLTH DIS, V4, P42, DOI 10.1017/S2040174412000578
   Rodriguez A, 2008, INT J OBESITY, V32, P550, DOI 10.1038/sj.ijo.0803741
   Rodriguez A, 2010, J CHILD PSYCHOL PSYC, V51, P134, DOI 10.1111/j.1469-7610.2009.02133.x
   Rofey DL, 2009, CHILD PSYCHIAT HUM D, V40, P517, DOI 10.1007/s10578-009-0141-1
   ROGERS PJ, 1979, PSYCHOPHARMACOLOGY, V66, P159, DOI 10.1007/BF00427624
   Sailer CF, 1976, SCIENCE, V192, P385
   Sajdyk TJ, 2004, NEUROPEPTIDES, V38, P225, DOI 10.1016/j.npep.2004.05.006
   Sampaio Leonardo Augusto Negreiros Parente Capela, 2012, Front Psychiatry, V3, P87, DOI 10.3389/fpsyt.2012.00087
   Sasayama D, 2013, J PSYCHIATR RES, V47, P401, DOI 10.1016/j.jpsychires.2012.12.001
   Scott KM, 2008, INT J OBESITY, V32, P192, DOI 10.1038/sj.ijo.0803701
   Sha HB, 2007, PHYSIOL GENOMICS, V31, P252, DOI 10.1152/physiolgenomics.00093.2007
   Simerly RB, 2008, PHYSIOL BEHAV, V94, P79, DOI 10.1016/j.physbeh.2007.11.023
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
   Soares-Miranda L, 2012, DIABETES-METAB RES, V28, P363, DOI 10.1002/dmrr.2281
   Soares-Miranda L, 2012, CIRC-ARRHYTHMIA ELEC, V5, P728, DOI 10.1161/CIRCEP.111.966259
   Spencer TJ, 2013, BIOL PSYCHIAT, V74, P84, DOI 10.1016/j.biopsych.2012.11.010
   Spindelegger C, 2009, MOL PSYCHIATR, V14, P1040, DOI 10.1038/mp.2008.35
   Staal WG, 2012, J AUTISM DEV DISORD, V42, P885, DOI 10.1007/s10803-011-1312-z
   Stanley SH, 2012, AUST J PRIM HEALTH, V18, P258, DOI 10.1071/PY11045
   STENZELPOORE MP, 1992, ENDOCRINOLOGY, V130, P3378, DOI 10.1210/en.130.6.3378
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Sullivan E. L., 2012, PHYSL BEHAV, DOI 10.1016/j.physbeh.2012.07.014
   Sullivan EL, 2011, NEUROENDOCRINOLOGY, V93, P1, DOI 10.1159/000322038
   Sullivan EL, 2010, FORUM NUTR, V63, P186, DOI 10.1159/000264406
   Sullivan EL, 2010, J NEUROSCI, V30, P3826, DOI 10.1523/JNEUROSCI.5560-09.2010
   Sullivan GM, 2006, BIOL PSYCHIAT, V60, P500, DOI 10.1016/j.biopsych.2005.11.022
   Sun MM, 2013, PSYCHIAT GENET, V23, P124, DOI 10.1097/YPG.0b013e328360c866
   Sun Xiaomian, 2008, Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, V25, P327
   Sysko R, 2012, J CLIN PSYCHIAT, V73, P1351, DOI 10.4088/JCP.12m07690
   TECOTT LH, 1995, NATURE, V374, P542, DOI 10.1038/374542a0
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   Tohmi M, 2004, NEUROSCI RES, V50, P67, DOI 10.1016/j.neures.2004.05.010
   Toker S, 2005, J OCCUP HEALTH PSYCH, V10, P344, DOI 10.1037/1076-8998.10.4.344
   Tonhajzerova I, 2009, INDIAN J MED RES, V130, P44
   Tozuka Y, 2010, NEUROCHEM INT, V57, P235, DOI 10.1016/j.neuint.2010.05.015
   Tyler CV, 2011, AJIDD-AM J INTELLECT, V116, P371, DOI 10.1352/1944-7558-116.5.371
   Unger TJ, 2007, J NEUROSCI, V27, P14265, DOI 10.1523/JNEUROSCI.3308-07.2007
   Valiengo L, 2013, DEPRESS ANXIETY, V30, P646, DOI 10.1002/da.22079
   Valtonen MK, 2012, SCAND J PUBLIC HEALT, V40, P674, DOI 10.1177/1403494812461730
   Vander Wal JS, 2012, CLIN PSYCHOL REV, V32, P49, DOI 10.1016/j.cpr.2011.11.001
   van der Wee NJ, 2008, J NUCL MED, V49, P757, DOI 10.2967/jnumed.107.045518
   Vogelzangs N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.8
   Volkow ND, 2008, NEUROIMAGE, V42, P1537, DOI 10.1016/j.neuroimage.2008.06.002
   Vucetic Z, 2010, ENDOCRINOLOGY, V151, P4756, DOI 10.1210/en.2010-0505
   Wallace JM, 2008, PLACENTA, V29, P718, DOI 10.1016/j.placenta.2008.05.006
   Wang GJ, 2009, J ADDICT MED, V3, P8, DOI 10.1097/ADM.0b013e31819a86f7
   Wang GJ, 2001, LANCET, V357, P354, DOI 10.1016/S0140-6736(00)03643-6
   Waring ME, 2008, PEDIATRICS, V122, pE1, DOI 10.1542/peds.2007-1955
   Watanabe Y, 2013, PSYCHIAT CLIN NEUROS, V67, P123, DOI 10.1111/pcn.12018
   Watanabe Y, 2010, PSYCHIAT CLIN NEUROS, V64, P217, DOI 10.1111/j.1440-1819.2010.02094.x
   Wei HG, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-52
   Wei HG, 2012, BBA-MOL BASIS DIS, V1822, P831, DOI 10.1016/j.bbadis.2012.01.011
   Weiss R, 2011, DIABETES CARE, V34, pS171, DOI 10.2337/dc11-s214
   WRIGHT DE, 1995, J COMP NEUROL, V351, P357, DOI 10.1002/cne.903510304
   Wu H, 2011, J NEUROPSYCH CLIN N, V23, P63, DOI 10.1176/appi.neuropsych.23.1.63
   Wu J, 2012, MOL NEUROBIOL, V45, P605, DOI 10.1007/s12035-012-8278-5
   Zhao G, 2009, INT J OBESITY, V33, P257, DOI 10.1038/ijo.2008.268
   Zhao GX, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-130
   Zhong WJ, 2010, DEPRESS ANXIETY, V27, P846, DOI 10.1002/da.20666
   Zhou QY, 1995, CELL, V83, P1197, DOI 10.1016/0092-8674(95)90145-0
NR 247
TC 4
Z9 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PY 2013
VL 98
IS 4
BP 254
EP 266
DI 10.1159/000355632
PG 13
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA AC3MW
UT WOS:000332426900002
PM 24080959
ER

PT J
AU James, AC
   James, G
   Cowdrey, FA
   Soler, A
   Choke, A
AF James, Anthony C.
   James, Georgina
   Cowdrey, Felicity A.
   Soler, Angela
   Choke, Aislinn
TI Cognitive behavioural therapy for anxiety disorders in children and
   adolescents
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Cognitive Therapy; Anxiety Disorders [therapy]; Randomized Controlled
   Trials as Topic; Adolescent; Child; Humans
ID RANDOMIZED CLINICAL-TRIAL; AUTISM SPECTRUM DISORDERS; GENERALIZED SOCIAL
   PHOBIA; 1-YEAR FOLLOW-UP; CHILDHOOD ANXIETY; ANXIOUS CHILDREN; PARENTAL
   INVOLVEMENT; EARLY INTERVENTION; DEPRESSIVE-DISORDERS; FAMILY MODALITIES
AB Background
   A previous Cochrane review (James 2005) showed that cognitive behavioural therapy (CBT) was effective in treating childhood anxiety disorders; however, questions remain regarding (1) the relative efficacy of CBT versus non-CBT active treatments; (2) the relative efficacy of CBT versus medication and the combination of CBT and medication versus placebo; and (3) the long-term effects of CBT.
   Objectives
   To examine (1) whether CBT is an effective treatment for childhood and adolescent anxiety disorders in comparison with (a) wait-list controls; (b) active non-CBT treatments (i.e. psychological placebo, bibliotherapy and treatment as usual (TAU)); and (c) medication and the combination of medication and CBT versus placebo; and (2) the long-term effects of CBT.
   Search methods
   Searches for this review included the Cochrane Central Register of Controlled Trials (CENTRAL) and the Cochrane Depression, Anxiety and Neurosis Group Register, which consists of relevant randomised controlled trials from the bibliographic databases The Cochrane Library (1970 to July 2012), EMBASE, (1970 to July 2012) MEDLINE (1970 to July 2012) and PsycINFO (1970 to July 2012).
   Selection criteria
   All randomised controlled trials (RCTs) of CBT versus waiting list, active control conditions, TAU or medication were reviewed. All participants must have met the criteria of the Diagnostic and Statistical Manual (DSM) or the International Classification of Diseases (ICD) for an anxiety diagnosis, excluding simple phobia, obsessive-compulsive disorder, post-traumatic stress disorder and elective mutism.
   Data collection and analysis
   The methodological quality of included trials was assessed by three reviewers independently. For the dichotomous outcome of remission of anxiety diagnosis, the odds ratio (OR) with 95% confidence interval (CI) based on the random-effects model, with pooling of data via the inverse variance method of weighting, was used. Significance was set at P < 0.05. Continuous data on each child's anxiety symptoms were pooled using the standardised mean difference (SMD).
   Main results
   Forty-one studies consisting of 1806 participants were included in the analyses. The studies involved children and adolescents with anxiety of mild to moderate severity in university and community clinics and school settings. For the primary outcome of remission of any anxiety diagnosis for CBT versus waiting list controls, intention-to-treat (ITT) analyses with 26 studies and 1350 participants showed an OR of 0.13 (95% CI 0.09 to 0.19, Z = 10.26, P < 0.0001), but with evidence of moderate heterogeneity (P = 0.04, I-2 = 33%). The number needed to treat (NNT) was 6.0 (95% CI 7.5 to 4.6). No difference in outcome was noted between individual, group and family/parental formats. ITT analyses revealed that CBT was no more effective than non-CBT active control treatments (six studies, 426 participants) or TAU in reducing anxiety diagnoses (two studies, 88 participants). The few controlled follow-up studies (n = 4) indicate that treatment gains in the remission of anxiety diagnosis are not statistically significant.
   Authors' conclusions
   Cognitive behavioural therapy is an effective treatment for childhood and adolescent anxiety disorders; however, the evidence suggesting that CBT is more effective than active controls or TAU or medication at follow-up, is limited and inconclusive.
C1 [James, Anthony C.; Cowdrey, Felicity A.] Univ Oxford, Dept Psychiat, Oxford, England.
   [James, Anthony C.; Choke, Aislinn] Warneford Hosp, Highfield Family & Adolescent Unit, Oxford OX3 7JX, England.
   [James, Georgina] Univ Durham, Sch Med Pharm & Hlth, Stockton On Tees, England.
   [Soler, Angela] Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England.
RP James, AC (reprint author), Warneford Hosp, Highfield Family & Adolescent Unit, Oxford OX3 7JX, England.
EM anthony.james@psych.ox.ac.uk
FU Oxford Healthcare NHS Foundation Trust, UK; Oxford University Department
   of Psychiatry, Warneford Hospital, Oxford, UK
FX Internal sourcesOxford Healthcare NHS Foundation Trust, UK.Oxford
   University Department of Psychiatry, Warneford Hospital, Oxford, UK.
CR Achenbach T, 1991, PROGRAM MANUAL CHILD
   Alfano, 2009, J AM ACAD CHILD ADOL, V48, P945
   Altman DG, 2012, STAT MED
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1987, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   American Psychiatric Association, 1980, DIAGN STAT MAN MENT
   [Anonymous], 2009, STAT IC 11 1 11
   Baer S, 2005, J AM ACAD CHILD PSY, V44, P258, DOI 10.1097/00004583-200503000-00010
   Barrett P, 2001, BRIT J CLIN PSYCHOL, V40, P399, DOI 10.1348/014466501163887
   Barrett PM, 1998, J CLIN CHILD PSYCHOL, V27, P459, DOI 10.1207/s15374424jccp2704_10
   Barrett PM, 1996, J CONSULT CLIN PSYCH, V64, P333, DOI 10.1037/0022-006X.64.2.333
   Barrington J, 2005, BEHAV CHANGE, V22, P29
   Beesdo K, 2007, ARCH GEN PSYCHIAT, V64, P903, DOI 10.1001/archpsyc.64.8.903
   BEIDEL DC, 1995, PSYCHOL ASSESSMENT, V7, P73, DOI 10.1037/1040-3590.7.1.73
   Beidel DC, 2007, J AM ACAD CHILD PSY, V46, P1622, DOI 10.1097/chi.0b013e318154bb57
   Beidel P, 2001, J CONSULT CLIN PSYCH, V68, P1072
   Bernstein GA, 2005, J AM ACAD CHILD PSY, V44, P1118, DOI 10.1097/01.chi.0000177323.40005.a1
   Birmaher B, 1999, SCREEN CHILD ANXIETY
   Bisson J, 2007, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD003388.pub3], DOI 10.1002/14651858.CD003388.PUB3]]
   Bittner A, 2007, J CHILD PSYCHOL PSYC, V48, P1174, DOI 10.1111/j.1469-7610.2007.01812.x
   BLAGG NR, 1984, BEHAV RES THER, V22, P119, DOI 10.1016/0005-7967(84)90100-1
   Breinholst S, 2012, J ANXIETY DISORD, V26, P416, DOI 10.1016/j.janxdis.2011.12.014
   Cartwright-Hatton S, 2011, J AM ACAD CHILD PSY, V50, P242, DOI 10.1016/j.jaac.2010.12.015
   Cartwright-Hatton S, 2004, BRIT J CLIN PSYCHOL, V43, P421, DOI 10.1348/0144665042388928
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Chan AW, 2005, BRIT MED J, V330, P753, DOI 10.1136/bmj.38356.424606.8F
   Chiu AW, 2009, J CHILD PSYCHOL PSYC, V50, P751, DOI 10.1111/j.1469-7610.2008.01996.x
   Chu BC, 2007, CLIN CHILD FAM PSYCH, V10, P352, DOI 10.1007/s10567-007-0028-2
   Cobham VE, 2012, J CONSULT CLIN PSYCH, V80, P465, DOI 10.1037/a0028205
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Compton SN, 2004, J AM ACAD CHILD PSY, V43, P930, DOI 10.1097/01.chi.0000127589.57468.bf
   Cornwall E, 1996, BEHAV CHANGE, V13, P223
   Costello EJ, 2004, PHOBIC AND ANXIETY DISORDERS IN CHILDREN AND ADOLESCENTS: A CLINICIANS GUIDE TO EFFECTIVE PSYCHOSOCIAL AND PHARMACOLOGICAL INTERVENTIONS, P61
   Dadds MR, 1997, J CONSULT CLIN PSYCH, V65, P627, DOI 10.1037/0022-006X.65.4.627
   Dadds MR, 1999, J CONSULT CLIN PSYCH, V67, P145, DOI 10.1037//0022-006X.67.1.145
   Essau C A, 2004, Versicherungsmedizin, V56, P123
   Flannery-Schroeder EC, 2000, COGNITIVE THER RES, V24, P251, DOI 10.1023/A:1005500219286
   Flannery-Schroeder EC, 1998, DISS ABSTR INT, V58, P5642
   Flannery-Schroeder EC, 2005, COGNITIVE THERAPY RE, V29, P253
   Flannery-Schroeder E, 2005, COGNITIVE THER RES, V29, P253, DOI 10.1007/s10608-005-3168-z
   Flannery-Schroeder EC, 1998, DISS ABSTR INT, V58, P5642
   Ford T, 2003, J AM ACAD CHILD PSY, V42, P1203, DOI 10.1097/01.chi.0000081820.25107.ae
   Forman EM, 2007, BEHAV MODIF, V31, P772, DOI 10.1177/0145445507302202
   Galla BM, 2012, CHILD PSYCHIAT HUM D, V43, P219, DOI 10.1007/s10578-011-0258-x
   Gallagher HM, 2004, J ANXIETY DISORD, V18, P459, DOI 10.1016/S0887-6185(03)00027-6
   Garcia-Lopez LJ, 2006, J ANXIETY DISORD, V20, P175, DOI 10.1016/j.janxdis.2005.01.003
   Gil-Bernal F, 2009, ANUARIO PSICOLOGIA, V40, P89
   Ginsburg GS, 2012, CHILD YOUTH CARE FOR, V41, P1, DOI 10.1007/s10566-011-9156-4
   Ginsburg GS, 2002, J AM ACAD CHILD PSY, V41, DOI 10.1097/00004583-200207000-00007
   Gould RL, 2012, J AM GERIATR SOC, V60, P218, DOI 10.1111/j.1532-5415.2011.03824.x
   Grave J, 2004, CLIN PSYCHOL REV, V24, P399, DOI 10.1016/j.cpr.2004.03.002
   Grills AE, 2003, J AM ACAD CHILD PSY, V42, P30, DOI 10.1097/01.CHI.0000024899.60748.EE
   Guy W, 1976, ECDEU ASSESSMENT MAN, P218
   Hayward C, 2000, J AM ACAD CHILD PSY, V39, P721, DOI 10.1097/00004583-200006000-00010
   Health Services Research Unit, 2004, DAT ICCS SPREADSH EM
   Herbert JD, 2009, J ANXIETY DISORD, V23, P167, DOI 10.1016/j.janxdis.2008.06.004
   Higgins JPT, COCHRANE HDB SYSTEMA
   Hill RM, 2011, CLIN PSYCHOL REV, V31, P1133, DOI 10.1016/j.cpr.2011.07.008
   Hirshfeld-Becker DR, 2010, J CONSULT CLIN PSYCH, V78, P498, DOI 10.1037/a0019055
   Holland D, 1995, DIAGNOSTIC INTERVIEW
   Holmes JM, 2006, P 29 AUSTRL ASS COGN
   Hudson JL, 2009, J AM ACAD CHILD PSY, V48, P533, DOI 10.1097/CHI.0b013e31819c2401
   Ipser JC, 2009, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD005170.pub2], DOI 10.1002/14651858.CD005170.PUB2]]
   James A, 2005, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD004690.pub2], DOI 10.1002/14651858.CD004690.PUB2]]
   Jansen M, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-16
   Joormann J, 2002, Z KL PSYCH PSYCHOTH, V31, P284, DOI 10.1026//1616-3443.31.4.284
   Kendall PC, 1997, J CONSULT CLIN PSYCH, V65, P366, DOI 10.1037/0022-006X.65.3.366
   KENDALL PC, 1994, J CONSULT CLIN PSYCH, V62, P100, DOI 10.1037/0022-006X.62.1.100
   Kendall PC, 2009, J CONSULT CLIN PSYCH, V77, P517, DOI 10.1037/a0013686
   Kendall PC, 2001, J AM ACAD CHILD PSY, V40, P787, DOI 10.1097/00004583-200107000-00013
   KENDALL PC, 1990, J ABNORM CHILD PSYCH, V18, P255, DOI 10.1007/BF00916564
   Kendall PC, 2008, J CONSULT CLIN PSYCH, V76, P282, DOI 10.1037/0022-006X.76.2.282
   King NJ, 1998, J AM ACAD CHILD PSY, V37, P395, DOI 10.1097/00004583-199804000-00017
   KOVACS M, 1989, ARCH GEN PSYCHIAT, V46, P776
   KUSHNER MG, 1990, AM J PSYCHIAT, V147, P685
   La Greca A, 1998, MANUAL SOCIAL ANXIET
   Lang R, 2010, DEV NEUROREHABIL, V13, P53, DOI 10.3109/17518420903236288
   Last CG, 1996, J AM ACAD CHILD PSY, V35, P1502, DOI 10.1097/00004583-199611000-00019
   Last CG, 1998, J AM ACAD CHILD PSY, V37, P404, DOI 10.1097/00004583-199804000-00018
   Last CG, 1997, J AM ACAD CHILD PSY, V36, P645, DOI 10.1097/00004583-199705000-00015
   Lau WY, 2010, BEHAV RES THER, V48, P1067, DOI 10.1016/j.brat.2010.07.007
   LAUPACIS A, 1988, NEW ENGL J MED, V318, P1728, DOI 10.1056/NEJM198806303182605
   Leong J, 2009, EUR CHILD ADOLES PSY, V18, P231, DOI 10.1007/s00787-008-0723-7
   Liber JM, 2010, J ABNORM CHILD PSYCH, V38, P683, DOI 10.1007/s10802-010-9394-1
   Lowry-Webster HM, 2003, BEHAV CHANGE, V20, P25, DOI 10.1375/bech.20.1.25.24843
   Masia-Warner C, 2011, DEPRESS ANXIETY, V28, P551
   Masia Warner Carrie, 2007, J Child Psychol Psychiatry, V48, P676, DOI 10.1111/j.1469-7610.2007.01737.x
   Masia-Warner C, 2005, J ABNORM CHILD PSYCH, V33, P707, DOI 10.1007/s10802-005-7649-z
   McNally Keehn RH, 2012, J AUTISM DEV DISORDE
   Melfsen S., 2011, CHILD ADOL PSYCH CL, V5, P1, DOI [10.1186/1753-2000-5-5, DOI 10.1186/1753-2000-5-5]
   Mendlowitz SL, 1999, J AM ACAD CHILD PSY, V38, P1223, DOI 10.1097/00004583-199910000-00010
   MENZIES RG, 1993, BEHAV RES THER, V31, P9, DOI 10.1016/0005-7967(93)90037-U
   Mifsud C, 2005, J AM ACAD CHILD PSY, V44, P996, DOI 10.1097/01.chi.0000175294.13441.87
   Moher D, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2535
   Muris P, 2002, J BEHAV THER EXP PSY, V33, P143, DOI 10.1016/S0005-7916(02)00025-3
   Myers K, 2002, J AM ACAD CHILD PSY, V41, P634, DOI 10.1097/00004583-200206000-00004
   Nauta MH, 2003, J AM ACAD CHILD PSY, V42, P1270, DOI 10.1097/01.chi.0000085752.71002.93
   O'Kearney RT, 2006, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD004856.pub2], DOI 10.1002/14651858.CD004856.PUB2]]
   Olivares J, 2005, PSICOTHEMA, V17, P1
   Ollendick TH, 1998, J CLIN CHILD PSYCHOL, V27, P156, DOI 10.1207/s15374424jccp2702_3
   Ordeig MT, 2004, P 32 C BRIT ASS BEH
   Otte Christian, 2011, Dialogues Clin Neurosci, V13, P413
   Peters JL, 2008, J CLIN EPIDEMIOL, V61, P991, DOI 10.1016/j.jclinepi.2007.11.010
   Pine DS, 2009, NEUROPSYCHOPHARMACOL, V34, P213, DOI 10.1038/npp.2008.113
   RAO JNK, 1992, BIOMETRICS, V48, P577, DOI 10.2307/2532311
   Reaven J, 2011, BRAIN RES, V1380, P255, DOI 10.1016/j.brainres.2010.09.075
   Reaven J, 2012, J CHILD PSYCHOL PSYC, V53, P410, DOI 10.1111/j.1469-7610.2011.02486.x
   Reynolds CR, 1985, REVISED CHILDRENS MA
   Reynolds S, 2012, CLIN PSYCHOL REV, V32, P251, DOI 10.1016/j.cpr.2012.01.005
   Rosa-Alcazar AI, 2007, TER PSICOL, V25, P63
   Saavedra LM, 2010, J CHILD PSYCHOL PSYC, V51, P924, DOI 10.1111/j.1469-7610.2010.02242.x
   Sanchez-Garcia R, 2009, AN PSICOL-SPAIN, V25, P241
   Sauter FM, 2009, CLIN CHILD FAM PSYCH, V12, P310, DOI 10.1007/s10567-009-0058-z
   Schneider S, 2011, PSYCHOTHER PSYCHOSOM, V80, P206, DOI 10.1159/000323444
   Schneier F, 1992, ARCH GEN PSYCHIAT, V48, P282, DOI DOI 10.1001/ARCHPSYC.1992.01820040034004
   Scott RW, 2005, J NATL MED ASSOC, V97, P13
   Seligman LD, 2011, CHILD ADOL PSYCH CL, V20, P217, DOI 10.1016/j.chc.2011.01.003
   Seligman LD, 2004, J CLIN CHILD ADOLESC, V33, P557, DOI 10.1207/s15374424jccp3303_13
   Settipani CA, 2012, J ANXIETY DISORD, V26, P459, DOI 10.1016/j.janxdis.2012.01.010
   Shortt AL, 2001, J CLIN CHILD PSYCHOL, V30, P525, DOI 10.1207/S15374424JCCP3004_09
   Silverman WK, 1987, ANXIETY DISORDER INT
   Silverman WK, 1999, J CONSULT CLIN PSYCH, V67, P995, DOI 10.1037//0022-006X.67.6.995
   Silverman WK, 2008, J CLIN CHILD ADOLESC, V37, P105, DOI 10.1080/15374410701817907
   Silverman WK, 1999, J CONSULT CLIN PSYCH, V67, P675, DOI 10.1037/0022-006X.67.5.675
   Silverman WK, 1996, ANXIETY PHOBIC DISOR
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Spence SH, 1997, J ABNORM PSYCHOL, V106, P280, DOI 10.1037//0021-843X.106.2.280
   Spence SH, 2000, J CHILD PSYCHOL PSYC, V41, P713, DOI 10.1017/S0021963099005934
   Spence SH, 2006, J CONSULT CLIN PSYCH, V74, P614, DOI 10.1037/0022-006X.74.3.614
   Spielberger C. D., 1973, STATE TRAIT ANXIETY
   Sung M, 2011, CHILD PSYCHIAT HUM D, V42, P634, DOI 10.1007/s10578-011-0238-1
   Suveg C, 2009, J ANXIETY DISORD, V23, P341, DOI 10.1016/j.janxdis.2009.01.003
   Thyrer BA, 1991, BEHAV MODIF, V15, P310
   Treadwell KRH, 1996, J CONSULT CLIN PSYCH, V64, P941, DOI 10.1037/0022-006X.64.5.941
   Walkup JT, 2008, NEW ENGL J MED, V359, P2753, DOI 10.1056/NEJMoa0804633
   WARREN R, 1984, ADOLESCENCE, V19, P893
   Waters AM, 2009, BEHAV RES THER, V47, P654, DOI 10.1016/j.brat.2009.04.008
   Weisz JR, 2012, ARCH GEN PSYCHIAT, V69, P274, DOI 10.1001/archgenpsychiatry.2011.147
   White SW, 2012, J AUTISM DEV DISORD, P1573
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Wood JJ, 2009, CHILD PSYCHIAT HUM D, V40, P301, DOI 10.1007/s10578-009-0127-z
   World Health Organisation, 1992, ICD 10 CLASS MENT BE
   World Health Organization, 1978, ICF 9 CLASS MENT BEH
NR 145
TC 7
Z9 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2013
IS 6
AR CD004690
DI 10.1002/14651858.CD004690.pub3
PG 107
WC Medicine, General & Internal
SC General & Internal Medicine
GA 174AH
UT WOS:000321124500003
ER

PT J
AU Nicholas, D
   Clarke, M
   Ghali, L
   Macintosh, C
AF Nicholas, David
   Clarke, Margaret
   Ghali, Laura
   Macintosh, Chris
TI Building online support for parents of youth and adults with Autism
   Spectrum Disorder using qualitative methods
SO INTERNATIONAL JOURNAL OF QUALITATIVE METHODS
LA English
DT Meeting Abstract
C1 [Nicholas, David; Clarke, Margaret; Ghali, Laura; Macintosh, Chris] Univ Calgary, Calgary, AB T2N 1N4, Canada.
NR 0
TC 0
Z9 0
PU UNIV ALBERTA, INT INST QUALITATIVE METHODOLOGY
PI EDMONTON
PA 5-217, EDMONTON CLINIC HEALTH ACAD, 11405 87 AVENUE, EDMONTON, AB T6G
   1C9, CANADA
SN 1609-4069
J9 INT J QUAL METH
JI Int. J. Qual. Meth.
PY 2013
VL 12
BP 736
EP 737
PG 2
WC Social Sciences, Interdisciplinary
SC Social Sciences - Other Topics
GA AB9CV
UT WOS:000332088100070
ER

PT J
AU Yukselen, A
   Yaban, EH
AF Yukselen, Arzu
   Yaban, E. Helin
TI Social Competence of Integrated Children With Mild Intellectual
   Disability
SO HACETTEPE UNIVERSITESI EGITIM FAKULTESI DERGISI-HACETTEPE UNIVERSITY
   JOURNAL OF EDUCATION
LA Turkish
DT Article
DE intellectual disability; integrated programs; social competence; problem
   behaviors
ID BEHAVIOR RATING FORM; EXTERNALIZING PROBLEMS; DEVELOPMENTAL DELAYS;
   EMOTIONAL-PROBLEMS; PEER RELATIONSHIPS; DOWN-SYNDROME; FRIENDSHIPS;
   DISORDERS; CHILDHOOD; AUTISM
AB This study examines the social competence of integrated children with mild intellectual disability (ID) by comparing parents' and teachers' ratings. The relationships between social behaviors and age and whether these behaviors vary as a function of years of teaching experience and type of integration are also investigated. Data is obtained through self-report questionnaires completed by parents and teachers of 106 4-18 years aged integrated children with ID from Ankara, Turkey. Descriptive analysis results indicate that correlations between parents' and teachers' reports range from low to moderate. Prosocial behaviors increase along with age although the relationships vary with respect to parents' and teachers' ratings. Parents' reports of hyperactivity/overly sensitive scores differentiate according to years of teaching experience and type of integration. Teachers' reports of self-isolated/ritualistic and insecure/anxious scores vary based on years of teaching experience. Effect of type of integration on teachers' reports of self-isolated/ritualistic scores is found.
C1 [Yukselen, Arzu; Yaban, E. Helin] Hacettepe Univ, Saglik Bilimleri Fak, Ankara, Turkey.
RP Yukselen, A (reprint author), Hacettepe Univ, Saglik Bilimleri Fak, Ankara, Turkey.
EM aipek@hacettepe.edu.tr; helinyaban@gmail.com
CR ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
   Akcamete G., 2004, OZEL GEREKSINIMLI OG
   Aman M, 2008, INT CLIN PSYCHOPHARM, V23, P232, DOI 10.1097/YIC.0b013e3282f94ad0
   Aman MG, 1996, RES DEV DISABIL, V17, P41, DOI 10.1016/0891-4222(95)00039-9
   Ang R. P., 2003, CHILD CARE PRACTICE, V9, P5, DOI DOI 10.1080/13575270302169
   Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156
   Bierman KL, 2000, J CLIN CHILD PSYCHOL, V29, P526, DOI 10.1207/S15374424JCCP2904_6
   Diamond K. E., 1994, EARLY ED DEV, V5, P301, DOI 10.1207/s15566935eed0504_5
   Elliott S., 2001, EXCEPTIONALITY, V9, P19, DOI 10.1080/09362835.2001.9666989
   Freeman SFN, 2002, AM J MENT RETARD, V107, P16, DOI 10.1352/0895-8017(2002)107<0016:CAQOTP>2.0.CO;2
   Gresham F. M., 2000, ASSESSMENT EFFECTIVE, V26, P51, DOI 10.1177/073724770002600107
   Guralnick M. J., 1996, DOWNS SYNDROME PSYCH, P147
   Guralnick M. J., 1990, J EARLY INTERVENTION, V14, P3, DOI 10.1177/105381519001400101
   GURALNICK MJ, 1995, AM J MENT RETARD, V99, P457
   Guralnick MJ, 2007, J APPL DEV PSYCHOL, V28, P64, DOI 10.1016/j.appdev.2006.10.004
   Guralnick MJ, 1996, CHILD DEV, V67, P471
   Hardiman S, 2009, RES DEV DISABIL, V30, P397, DOI 10.1016/j.ridd.2008.07.006
   HOWING PT, 1990, SOC WORK, V35, P460
   HYMEL S, 1990, CHILD DEV, V61, P2004, DOI 10.1111/j.1467-8624.1990.tb03582.x
   Innes FK, 1999, TOP EARLY CHILD SPEC, V19, P103, DOI 10.1177/027112149901900204
   KUPERSMIDT JB, 1990, CHILD DEV, V61, P1350, DOI 10.1111/j.1467-8624.1990.tb02866.x
   Lecavalier L, 2004, J AUTISM DEV DISORD, V34, P709, DOI 10.1007/s10803-004-5291-1
   Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
   Milfont TL, 2004, J ENVIRON PSYCHOL, V24, P289, DOI 10.1016/j.jenvp.2004.09.001
   Mircea CE, 2010, J MENT HEALTH RES IN, V3, P51, DOI 10.1080/19315860903520515
   Montano Z, 2011, J CHILD FAM STUD, V20, P473, DOI 10.1007/s10826-010-9414-3
   Neuharth-Pritchett S., 2006, J RES CHILDHOOD ED
   Okagaki L, 1998, EARLY CHILD RES Q, V13, P67, DOI 10.1016/S0885-2006(99)80026-X
   PARKER JG, 1987, PSYCHOL BULL, V102, P357, DOI 10.1037//0033-2909.102.3.357
   PECK CA, 1992, J EARLY INTERVENTION, V16, P53
   Renk K, 2004, CLIN PSYCHOL REV, V24, P239, DOI 10.1016/j.cpr.2004.01.004
   Rojahn J, 1993, Ann Clin Psychiatry, V5, P163, DOI 10.3109/10401239309148980
   Rubin K. H., 1992, HDB SOCIAL DEV LIFES, P283
   Sigman M, 1999, MONOGR SOC RES CHILD, V64, P1, DOI 10.1111/1540-5834.00002
   Tasse MJ, 1996, RES DEV DISABIL, V17, P59, DOI 10.1016/0891-4222(95)00037-2
   Tasse MJ, 2000, AM J MENT RETARD, V105, P252, DOI 10.1352/0895-8017(2000)105<0252:CPATRO>2.0.CO;2
   van der Ende J, 2012, PSYCHOL ASSESSMENT, V24, P293, DOI 10.1037/a0025500
   WILLIAMS GA, 1992, AM J MENT RETARD, V96, P373
   Yukselen A., 2005, COCUK GELISIMI VE EG, V2, P1
   Yukselen A., 2003, THESIS HACETTEPE U A
NR 40
TC 0
Z9 0
PU HACETTEPE UNIV
PI ANKARA
PA HACETTEPE UNIV, ANKARA, 6532, TURKEY
SN 1300-5340
J9 HACET U EGITIM FAK
JI Hacet. Univ. Egit. Fak. Derg.
PY 2013
VL 28
IS 3
BP 454
EP 468
PG 15
WC Education & Educational Research
SC Education & Educational Research
GA AB3AC
UT WOS:000331662700034
ER

PT J
AU Saemundsen, E
   Magnusson, P
   Georgsdottir, I
   Egilsson, E
   Rafnsson, V
AF Saemundsen, Evald
   Magnusson, Pall
   Georgsdottir, Ingibjorg
   Egilsson, Erlendur
   Rafnsson, Vilhjalmur
TI Prevalence of autism spectrum disorders in an Icelandic birth cohort
SO BMJ OPEN
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; EPILEPSY; CHILDREN
AB Objectives: A steady increase in the prevalence of autism spectrum disorders (ASD) has been reported in studies based on different methods, requiring adjustment for participation and missing data. Recent studies with high ASD prevalence rates rarely report on co-occurring medical conditions. The aim of the study was to describe the prevalence of clinically confirmed cases of ASD in Iceland and concomitant medical conditions.
   Design: The cohort is based on a nationwide database on ASD among children born during 1994-1998.
   Participants: A total of 267 children were diagnosed with ASD, 197 boys and 70 girls. Only clinically confirmed cases were included. All received physical and neurological examination, standardised diagnostic workup for ASD, as well as cognitive testing. ASD diagnosis was established by interdisciplinary teams. Information on medical conditions and chromosomal testing was obtained by record linkage with hospital registers.
   Setting: Two tertiary institutions in Iceland. The population registry recorded 22 229 children in the birth cohort.
   Results: Prevalence of all ASD was 120.1/10 000 (95% CI 106.6 to 135.3), for boys 172.4/10 000 (95% CI 150.1 to 198.0) and for girls 64.8/10 000 (95% CI 51.3 to 81.8). Prevalence of all medical conditions was 17.2% (95% CI 13.2 to 22.2), including epilepsy of 7.1% (95% CI 4.6 to 10.8). The proportion of ASD cases with cognitive impairment (intellectual quotient <70) was 45.3%, but only 34.1% were diagnosed with intellectual disability (ID). Children diagnosed earlier or later did not differ on mean total score on a standardised interview for autism.
   Conclusions: The number of clinically verified cases is larger than in previous studies, yielding a prevalence of ASD on a similar level as found in recent non-clinical studies. The prevalence of co-occurring medical conditions was high, considering the low proportion of ASD cases that also had ID. Earlier detection is clearly desirable in order to provide counselling and treatment.
C1 [Saemundsen, Evald; Georgsdottir, Ingibjorg] State Diagnost & Counselling Ctr, Div Autism, Kopavogur, Iceland.
   [Saemundsen, Evald] Univ Iceland, Fac Med, Reykjavik, Iceland.
   [Magnusson, Pall; Egilsson, Erlendur] Landspitali Univ Hosp, Dept Child & Adolescent Psychiat, Reykjavik, Iceland.
   [Rafnsson, Vilhjalmur] Univ Iceland, Fac Med, Dept Prevent Med, Reykjavik, Iceland.
RP Saemundsen, E (reprint author), State Diagnost & Counselling Ctr, Div Autism, Kopavogur, Iceland.
EM evald@greining.is
FU Freemasons Fund of the Icelandic Order of Freemasons
FX This work was partly supported by the Freemasons Fund of the Icelandic
   Order of Freemasons. The sponsors played no role in the design and
   conduct of the study; in the collection, analysis and interpretation of
   the data, or in the preparation, review or approval of the manuscript.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Bayley N, 1993, MANUAL BAYLEY SCALES
   Boltor PF, 2011, BRIT J PSYCHIAT, V198, P289, DOI 10.1192/bjp.bp.109.076877
   Bolton PF, 2009, J NEURODEV DISORD, V1, P102, DOI 10.1007/s11689-009-9021-z
   Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
   Cohen D, 2005, J AUTISM DEV DISORD, V35, P103, DOI 10.1007/s10803-004-1038-2
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Gudmundsson E, 2003, MANUAL WECHSLER PRES
   Harris SW, 2008, AM J MENT RETARD, V113, P427, DOI 10.1352/2008.113:427-438
   Jonsdottir SL, 2007, J AUTISM DEV DISORD, V37, P1361, DOI 10.1007/s10803-006-0282-z
   Kawamura Y, 2008, PSYCHIAT CLIN NEUROS, V62, P152, DOI 10.1111/j.1440-1819.2008.01748.x
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Kocovska E, 2012, J AUTISM DEV DISORD, V42, P1959, DOI 10.1007/s10803-012-1444-9
   Lord C., 2001, AUTISM DIAGNOSTIC OB
   Magnusson GT, 1977, LAEKNABLADID, V63, P237
   Magnusson P, 2001, J AUTISM DEV DISORD, V31, P153, DOI 10.1023/A:1010795014548
   McDonald ME, 2010, ENVIRON SCI TECHNOL, V44, P2112, DOI 10.1021/es902057k
   Newcombe R, 2003, STAT CONFIDENCE, P105
   Posserud M, 2010, SOC PSYCH PSYCH EPID, V45, P319, DOI 10.1007/s00127-009-0087-4
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Salvarsdottir K, 2006, ICELANDIC STANDARDIZ
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168
   Statistics Iceland, CHILDR PREPR I SEX A
   Statistics Iceland, POP SEX AG 1841 2010
   Wechsler D., 1992, WECHSLER INTELLIGENC
   Wechsler D., 1989, MANUAL WECHSLER PRES
   Whiteley P, 2010, AUTISM INSIGHTS, V2, P17
   WHO, 1993, ICD 10 CLASS MENT BE
   WHO, GLOB HLTH OBS DAT RE
NR 34
TC 6
Z9 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2013
VL 3
IS 6
AR e002748
DI 10.1136/bmjopen-2013-002748
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 301WA
UT WOS:000330561600030
ER

PT J
AU Ozen, A
   Ergenekon, Y
   Ulke-Kurkcuoglu, B
   Genc, D
AF Ozen, Arzu
   Ergenekon, Yasemin
   Ulke-Kurkcuoglu, Burcu
   Genc, Derya
TI OPINIONS OF SPECIAL EDUCATION TEACHERS ABOUT ACTIVITY-BASED INTERVENTION
SO HACETTEPE UNIVERSITESI EGITIM FAKULTESI DERGISI-HACETTEPE UNIVERSITY
   JOURNAL OF EDUCATION
LA English
DT Article
DE Developmental disabilities; early intervention; activity-based
   intervention; teacher opinions; special education teachers
ID SMALL-GROUP INSTRUCTION; CONSTANT-TIME DELAY;
   DEVELOPMENTAL-DISABILITIES; EMBEDDED INSTRUCTION; PLAY SKILLS; CHILDREN;
   AUTISM; PRESCHOOLERS; ACQUISITION; SETTINGS
AB This study aims to determine whether or not teachers working with children with developmental disabilities use daily routines, transitions and, planned play activities that are among the basic elements of Activity-Based Intervention (ABI) into instruction. The study also investigates how the teachers implement instructional procedures in order to teach target skills and concepts to their students if they use these activities into instruction. Semi-structured interviews were conducted with participants, and data were analyzed via inductive analysis technique in the study. At the end of analyses, three main themes and sub-themes were identified. Findings of the study showed that teachers have limitations in using ABI strategies systematically in their classes. In spite of these limitations they deliver positive opinions regarding ABI applications. Offering ABI strategies as an alternative instruction to teachers working with students with developmental disabilities and improving their competence to conduct these strategies may contribute both to increase in successful practices and occur a positive atmosphere in the classroom settings.
C1 [Ozen, Arzu; Ergenekon, Yasemin; Ulke-Kurkcuoglu, Burcu; Genc, Derya] Anadolu Univ, Eskisehir, Turkey.
RP Ozen, A (reprint author), Anadolu Univ, Eskisehir, Turkey.
EM aozen@anadolu.edu.tr; yergenek@anadolu.edu.tr;
   bulkekurkcuoglu@anadolu.edu.tr; deryagenc@anadolu.edu.tr
CR Alberto PA, 2009, APPL BEHAV ANAL TEAC
   Bakkaloglu H, 2008, KURAM UYGUL EGIT BIL, V8, P393
   Barton EE, 2008, TOP EARLY CHILD SPEC, V28, P109, DOI 10.1177/0271121408318799
   Bricker D., 2001, INFANT TODDLER INTER, V11, P11
   Bricker D., 1998, ACTIVITY BASED APPRO
   Buysse V, 1996, J EARLY INTERVENTION, V20, P189
   Colozzi GA, 2008, EDUC TRAIN DEV DISAB, V43, P226
   Creswell J. W., 2005, ED RES PLANNING COND, V2nd
   Daugherty S, 2001, TOP EARLY CHILD SPEC, V21, P213, DOI 10.1177/027112140102100402
   FOX L, 1993, TOP EARLY CHILD SPEC, V13, P308
   Garfinkle AN, 2002, TOP EARLY CHILD SPEC, V22, P26, DOI 10.1177/027112140202200103
   Gazdag G, 1990, J EARLY INTERVENTION, V14, P62
   Horn E, 2000, TOP EARLY CHILD SPEC, V20, P208, DOI 10.1177/027112140002000402
   Hunter K., 2004, J POSIT BEHAV INTERV, V6, P214
   Kerr M. M., 1998, STRATEGIES MANAGING
   Kurt O, 2008, TOP EARLY CHILD SPEC, V28, P53, DOI 10.1177/0271121408316046
   Lieber J., 1993, EARLY EDUC DEV, V4, P148, DOI 10.1207/s15566935eed0403_1
   Macy M. G., 2007, EARLY CHILD DEV CARE, V177, P107, DOI [10.1080/03004430500337265, DOI 10.1080/03004430500337265]
   McBride BJ, 2003, TOP EARLY CHILD SPEC, V23, P5, DOI 10.1177/027112140302300102
   McDonnell A. P., 1999, TOP EARLY CHILD SPEC, V19, P203
   McDonnell J, 2006, EDUC TRAIN DEV DISAB, V41, P125
   McDonnell J., 2004, ED TREATMENT CHILDRE, V27, P46
   Morrison RS, 2002, J EARLY INTERVENTION, V25, P58, DOI 10.1177/105381510202500106
   National Autism Center, 2009, NAT STAND REP
   Pretti-Frontczak K., 2004, ACTIVITY BASED APPRO
   Ridgley R., 2002, YOUNG EXCEPTIONAL CH, V6, P18, DOI 10.1177/109625060200600103
   Sewell TJ, 1998, J EARLY INTERVENTION, V21, P132
   Thomas DR, 2003, GEN INDUCTIVE APPROA
   Venn M. L., 1993, EARLY CHILDHOOD RES, V8, P277, DOI DOI 10.1016/S0885-2006(05)80068-7
   WARREN SF, 1992, J EARLY INTERVENTION, V16, P235
   Wilbers J. S., 1994, INCLUDING CHILDREN S, P151
   Wolery M, 2002, TOP EARLY CHILD SPEC, V22, P14, DOI 10.1177/027112140202200102
NR 32
TC 0
Z9 0
PU HACETTEPE UNIV
PI ANKARA
PA HACETTEPE UNIV, ANKARA, 6532, TURKEY
SN 1300-5340
J9 HACET U EGITIM FAK
JI Hacet. Univ. Egit. Fak. Derg.
PY 2013
IS 44
BP 262
EP 274
PG 13
WC Education & Educational Research
SC Education & Educational Research
GA 301SQ
UT WOS:000330552800023
ER

PT J
AU Kajta, M
   Wojtowicz, AK
AF Kajta, Malgorzata
   Wojtowicz, Anna K.
TI Impact of endocrine-disrupting chemicals on neural development and the
   onset of neurological disorders
SO PHARMACOLOGICAL REPORTS
LA English
DT Review
DE estrogen receptors; aryl hydrocarbon receptors; PPAR gamma; RXR; fetal
   basis of adult-onset disease; nervous system
ID ARYL-HYDROCARBON RECEPTOR; POLYCYCLIC AROMATIC-HYDROCARBONS;
   BLOOD-BRAIN-BARRIER; BISPHENOL-A; SEXUAL-DIFFERENTIATION; IN-UTERO;
   POLYCHLORINATED-BIPHENYLS; HIPPOCAMPAL NEUROGENESIS; LACTATIONAL
   EXPOSURE; PARKINSONS-DISEASE
AB Even though high doses of organic pollutants are toxic, relatively low concentrations have been reported to cause long-term alterations in functioning of individual organisms, populations and even next generations. Among these pollutants are dioxins, polychlorinated biphenyls, pesticides, brominated flame retardants, plasticizers (bisphenol A, nonylphenol, and phthalates) as well as personal care products and drugs. In addition to toxic effects, they are able to interfere with hormone receptors, hormone synthesis or hormone conversion. Because these chemicals alter hormone-dependent processes and disrupt functioning of the endocrine glands, they have been classified as endocrine-disrupting chemicals (EDCs). Because certain EDCs are able to alter neural transmission and the formation of neural networks, the term neural-disrupting chemicals has been introduced, thus implicating EDCs in the etiology of neurological disorders. Recently, public concern has been focused on the effects of EDCs on brain function, concomitantly with an increase in neuropsychiatric disorders, including autism, attention deficit and hyperactivity disorder as well as learning disabilities and aggressiveness. Several lines of evidence suggest that exposure to EDCs is associated with depression and could result in neural degeneration. EDCs act via several classes of receptors with the best documented mechanisms being reported for nuclear steroid and xenobiotic receptors. Low doses of EDCs have been postulated to cause incomplete methylation of specific gene regions in the young brain and to impair neural development and brain functions across generations. Efforts are needed to develop systematic epidemiological studies and to investigate the mechanisms of action of EDCs in order to fully understand their effects on wildlife and humans.
C1 [Kajta, Malgorzata; Wojtowicz, Anna K.] Polish Acad Sci, Inst Pharmacol, Dept Expt Neuroendocrinol, PL-31343 Krakow, Poland.
   [Wojtowicz, Anna K.] Univ Agr, Lab Genom & Biotechnol, PL-30274 Krakow, Poland.
RP Kajta, M (reprint author), Polish Acad Sci, Inst Pharmacol, Dept Expt Neuroendocrinol, Smetna 12, PL-31343 Krakow, Poland.
EM kajta@if-pan.krakow.pl
CR Anway MD, 2005, SCIENCE, V308, P1466, DOI 10.1126/science.1108190
   Bauer B, 2006, MOL PHARMACOL, V70, P1212, DOI 10.1124/mol.106.023796
   Braun JM, 2009, ENVIRON HEALTH PERSP, V117, P1945, DOI 10.1289/ehp.0900979
   Briz V, 2011, TOXICOL SCI, V120, P413, DOI 10.1093/toxsci/kfr019
   Brown JS, 2009, SCHIZOPHRENIA BULL, V35, P256, DOI 10.1093/schbul/sbm147
   Chen WQ, 2011, NEUROTOXICOLOGY, V32, P355, DOI 10.1016/j.neuro.2011.03.008
   Cho SJ, 2002, MOL CELLS, V14, P238
   Collins LL, 2008, TOXICOL SCI, V103, P125, DOI 10.1093/toxsci/kfn017
   Crews D, 2010, HORM-INT J ENDOCRINO, V9, P41
   Darras VM, 2008, CEREBELLUM, V7, P26, DOI 10.1007/s12311-008-0004-5
   Day M, 2005, BEHAV BRAIN RES, V164, P128, DOI 10.1016/j.bbr.2005.05.011
   de Joode BV, 2001, LANCET, V357, P1014
   Devi CB, 2005, INT J DEV NEUROSCI, V23, P375, DOI 10.1016/j.ijdevneu.2004.11.003
   Dong W, 2004, TOXICOL SCI, V77, P109, DOI 10.1093/toxsci/kfh023
   Duffard R, 2002, ANN NY ACAD SCI, V965, P305
   Edwards SC, 2010, ENVIRON HEALTH PERSP, V118, P1326, DOI 10.1289/ehp.0901070
   Eriksson P, 2000, NEUROTOXICOLOGY, V21, P37
   Fitsanakis VA, 2006, NEUROCHEM INT, V48, P426, DOI 10.1016/j.neuint.2005.10.012
   Fitzgerald EF, 2008, ENVIRON HEALTH PERSP, V116, P209, DOI 10.1289/ehp.10432
   Gassmann K, 2010, ENVIRON HEALTH PERSP, V118, P1571, DOI 10.1289/ehp.0901545
   Gilbert ME, 2012, NEUROTOXICOLOGY, V33, P842, DOI 10.1016/j.neuro.2011.11.005
   Gordon MD, 2006, J BIOL CHEM, V281, P22429, DOI 10.1074/jbc.R600015200
   Hatcher-Martin JM, 2012, NEUROTOXICOLOGY, V33, P1298, DOI 10.1016/j.neuro.2012.08.002
   Herbstman JB, 2010, ENVIRON HEALTH PERSP, V118, P712, DOI 10.1289/ehp.0901340
   Hu VW, 2012, NEUROTOXICOLOGY, V33, P1434, DOI 10.1016/j.neuro.2012.07.009
   Huang SPC, 2010, TOXICOL SCI, V114, P124, DOI 10.1093/toxsci/kfp296
   Ibrahim WNW, 2013, TOXICOL APPL PHARM, V269, P51, DOI 10.1016/j.taap.2013.03.003
   Ikeda M, 2005, TOXICOL APPL PHARM, V205, P98, DOI 10.1016/j.taap.2004.09.010
   Ishido M, 2007, TOXICOL LETT, V173, P66, DOI 10.1016/j.toxlet.2007.06.014
   Ishido M, 2010, TOXICOL IN VITRO, V24, P552, DOI 10.1016/j.tiv.2009.11.005
   Jang YJ, 2012, TOXICOLOGY, V296, P73, DOI 10.1016/j.tox.2012.03.007
   Jones DC, 2008, BIOCHEM PHARMACOL, V76, P569, DOI 10.1016/j.bcp.2008.05.010
   Kajta M, 2003, ENDOCRINE, V21, P3, DOI 10.1385/ENDO:21:1:3
   Kajta M, 2007, NEUROSCIENCE, V145, P592, DOI 10.1016/j.neuroscience.2006.11.059
   Kajta M, 2009, NEUROSCIENCE, V158, P811, DOI 10.1016/j.neuroscience.2008.10.045
   Kakeyama M, 2001, NEUROREPORT, V12, P4009, DOI 10.1097/00001756-200112210-00031
   Kawajiri K, 2007, ARCH BIOCHEM BIOPHYS, V464, P207, DOI 10.1016/j.abb.2007.03.038
   Ki YW, 2013, TOXICOL LETT, V218, P235, DOI 10.1016/j.toxlet.2013.02.003
   Kim J, 2013, OCCUP ENVIRON MED, V70, P303, DOI 10.1136/oemed-2012-101005
   Kubo K, 2001, NEUROSCI LETT, V304, P73, DOI 10.1016/S0304-3940(01)01760-8
   Kubo K, 2003, NEUROSCI RES, V45, P345, DOI 10.1016/S0168-0102(02)00251-1
   Kuchiiwa S, 2002, NEUROSCI LETT, V317, P73, DOI 10.1016/S0304-3940(01)02434-X
   Latchney SE, 2013, J NEUROCHEM, V125, P430, DOI 10.1111/jnc.12130
   Latchney SE, 2011, STEM CELLS DEV, V20, P313, DOI 10.1089/scd.2009.0529
   le Maire A, 2009, EMBO REP, V10, P367, DOI 10.1038/embor.2009.8
   Lim CK, 2009, TOXICOLOGY, V264, P145, DOI 10.1016/j.tox.2009.08.015
   Lin CH, 2009, J NEUROCHEM, V111, P777, DOI 10.1111/j.1471-4159.2009.06364.x
   Barrett DH, 2003, MIL MED, V168, P153
   Nayar T, 2002, EXP TOXICOL PATHOL, V53, P461
   Ogiue-Ikeda M, 2008, BRAIN RES REV, V57, P363, DOI 10.1016/j.brainresrev.2007.06.010
   Okada M, 2010, INT J MOL SCI, V11, P4114, DOI 10.3390/ijms11104114
   O'Reilly EJ, 2010, AM J EPIDEMIOL, V171, P876, DOI 10.1093/aje/kwq023
   Parihar VK, 2013, NEUROPSYCHOPHARMACOL, V38, P2348, DOI 10.1038/npp.2013.158
   Parron T, 2011, TOXICOL APPL PHARM, V256, P379, DOI 10.1016/j.taap.2011.05.006
   Perera FP, 2006, ENVIRON HEALTH PERSP, V114, P1287, DOI 10.1289/ehp.9084
   Perlman WR, 2005, BIOL PSYCHIAT, V58, P812, DOI 10.1016/j.biopsych.2005.04.047
   Poimenova A, 2010, NEUROSCIENCE, V167, P741, DOI 10.1016/j.neuroscience.2010.02.051
   Rocha-Amador D, 2009, NEUROTOXICOLOGY, V30, P1149, DOI 10.1016/j.neuro.2009.09.003
   Ross SJM, 2010, NEUROTOXICOL TERATOL, V32, P452, DOI 10.1016/j.ntt.2010.03.004
   Salama J, 2003, ENVIRON HEALTH PERSP, V111, P1278, DOI 10.1289/ehp.6126
   Sanchez-Martin FJ, 2011, J NEUROCHEM, V118, P153, DOI 10.1111/j.1471-4159.2011.07291.x
   Santiago RM, 2010, PROG NEURO-PSYCHOPH, V34, P1104, DOI 10.1016/j.pnpbp.2010.06.004
   Shutoh Y, 2009, J TOXICOL SCI, V34, P469
   Soudi M, 2005, TOXICOLOGY, V214, P113
   Suzuki T, 2003, NEUROSCIENCE, V117, P639, DOI 10.1016/S0306-4522(02)00935-1
   Wang L, 2003, P NATL ACAD SCI USA, V100, P703, DOI 10.1073/pnas.242735799
   Wang XQ, 2010, MOL PHARMACOL, V78, P376, DOI 10.1124/mol.110.063685
   Weiss B, 2011, J NEUROL SCI, V305, P11, DOI 10.1016/j.jns.2011.03.014
   Weisskopf MG, 2013, AM J EPIDEMIOL, V178, P1051, DOI 10.1093/aje/kwt089
   Westberg L, 2008, J PSYCHIATR NEUROSCI, V33, P319
   Wilson ME, 2008, FRONT NEUROENDOCRIN, V29, P375, DOI 10.1016/j.yfrne.2008.03.002
   Wojtowicz AK, 2014, NEUROTOX RES, V25, P311, DOI 10.1007/s12640-013-9434-z
   Xu XH, 2010, TOXICOL APPL PHARM, V249, P188, DOI 10.1016/j.taap.2010.09.007
   Yi JH, 2008, BRAIN RES, V1244, P164, DOI 10.1016/j.brainres.2008.09.074
   Yu L, 2011, J HAZARD MATER, V192, P1860, DOI 10.1016/j.jhazmat.2011.07.027
NR 75
TC 5
Z9 5
PU POLISH ACAD SCIENCES INST PHARMACOLOGY
PI KRAKOW
PA SMETNA 12, 31-343 KRAKOW, POLAND
SN 1734-1140
J9 PHARMACOL REP
JI Pharmacol. Rep.
PY 2013
VL 65
IS 6
BP 1632
EP 1639
PG 8
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AA2UK
UT WOS:000330949400021
PM 24553011
ER

PT J
AU Maria, P
   Antona, V
   Graziano, L
   Consiglio, V
   Salzano, E
   Vecchio, D
   Lauricella, SA
   Corsello, G
AF Maria, Piccione
   Antona, Vincenzo
   Graziano, Luciano
   Consiglio, Valeria
   Salzano, Emanuela
   Vecchio, Davide
   Lauricella, Salvatrice Antonia
   Corsello, Giovanni
TI X-LINKED INTELLECTUAL DISABILITY
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE intellectual disability X-linked; syndromic forms; dysmorphic features
ID SENSORINEURAL HEARING-LOSS; COPY NUMBER VARIATIONS; MENTAL-RETARDATION;
   RETT-SYNDROME; EXPRESSIVE LANGUAGE; RISK-FACTORS; EPILEPSY; AUTISM;
   ADOLESCENTS; PROFILES
AB The intellectual disability is found in approximately 2-3% of the population in a mild-to-moderate form and 0.5-1% in a moderate-to-severe form. The mutations on the chromosome X are responsible for both syndromic and non-syndromic intellectual disability. In the syndromic forms behavioral disorders, autism and/or seizures are frequent.
C1 [Maria, Piccione; Antona, Vincenzo; Graziano, Luciano; Salzano, Emanuela; Vecchio, Davide; Corsello, Giovanni] Univ Palermo, Dipartimento Sci Promoz Salute & Materno Infantil, I-90133 Palermo, Italy.
   [Consiglio, Valeria] CRR Malattie Rare AOOR Villa Sofia Cervello Paler, Palermo, Italy.
   [Lauricella, Salvatrice Antonia] Lab Citogenet Med AOOR Villa Sofia Cervello Paler, Palermo, Italy.
RP Maria, P (reprint author), Via A Giordano 3, I-90127 Palermo, Italy.
CR Bahi-Buisson N, 2013, HAND CLINIC, V111, P281, DOI 10.1016/B978-0-444-52891-9.00031-2
   Bao XH, 2013, DEV MED CHILD NEUROL, V55, P553, DOI 10.1111/dmcn.12093
   Bassani S, 2013, NEUROSCIENTIST, V19, P541, DOI 10.1177/1073858413493972
   Buse M, 2013, ACTA MEDICA MEDITERR, V29, P241
   Coffee B, 2009, AM J HUM GENET, V85, P503, DOI 10.1016/j.ajhg.2009.09.007
   Cook D, 2013, DEV NEUROBIOL, DOI 10.1002/dneu.22096
   des Portes V, 2013, HAND CLINIC, V111, P297, DOI 10.1016/B978-0-444-52891-9.00035-X
   Dolce A, 2013, PEDIATR NEUROL, V48, P337, DOI 10.1016/j.pediatrneurol.2012.11.001
   Finestack LH, 2010, J SPEECH LANG HEAR R, V53, P1334, DOI 10.1044/1092-4388(2010/09-0125)
   Gibbons R, 2006, ORPHANET J RARE DIS, V1, DOI 10.1186/1750-1172-1-15
   Graziano F, 2013, ACTA MEDICA MEDITERR, V29, P333
   Guillén-Navarro E, 2006, Rev Neurol, V42 Suppl 1, pS45
   Iwase S, 2011, NAT STRUCT MOL BIOL, V18, P769, DOI 10.1038/nsmb.2062
   Kover ST, 2010, J INTELL DISABIL RES, V54, P246, DOI 10.1111/j.1365-2788.2010.01255.x
   Mari F, 2005, HUM MOL GENET, V14, P1935, DOI 10.1093/hmg/ddi198
   Martines F, 2011, INT J PEDIATR OTORHI, V75, P754, DOI 10.1016/j.ijporl.2011.01.031
   Martines F, 2013, INT J PEDIATR OTORHI, V77, P513, DOI 10.1016/j.ijporl.2012.12.023
   McDuffie A, 2012, AJIDD-AM J INTELLECT, V117, P18, DOI 10.1352/1944-7558-117.1.18
   Piro E, 2013, ITAL J PEDIATR, V14, P32
   Piro E, 2013, ACTA MEDICA MEDITERR, V29, P317
   Piro E, 2013, ACTA MEDICA MEDITERR, V29, P337
   Piro E, 2013, ACTA MEDICA MEDITERR, V29, P327
   Raymond FL, 2006, J MED GENET, V43, P193, DOI 10.1136/jmg.2005.033043
   Ricciardi S, 2012, NAT CELL BIOL, V14, P911, DOI 10.1038/ncb2566
   Salvago P, 2013, EUR ARCH OTO-RHINO-L, V270, P3049, DOI 10.1007/s00405-013-2379-2
   Stromme P, 2002, NAT GENET, V30, P441, DOI 10.1038/ng862
   Tabolacci Elisabetta, 2013, Methods Mol Biol, V1010, P141, DOI 10.1007/978-1-62703-411-1_10
   Thienpont B, 2007, EUR J HUM GENET, V15, P1094, DOI 10.1038/sj.ejhg.5201878
NR 28
TC 0
Z9 0
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2013
VL 29
IS 4
BP 799
EP 802
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 295YB
UT WOS:000330151200033
ER

PT J
AU Wiaderkiewicz, J
   Glowacka, M
   Grabowska, M
   Barski, JJ
AF Wiaderkiewicz, Jan
   Glowacka, Marta
   Grabowska, Marta
   Barski, Jaroslaw-Jerzy
TI Ultrasonic vocalizations (USV) in the three standard laboratory mouse
   strains: Developmental analysis
SO ACTA NEUROBIOLOGIAE EXPERIMENTALIS
LA English
DT Article
DE USV; laboratory mouse; inbred strains; development
ID INBRED STRAINS; YOUNG MICE; AUTISM; CALLS; MODEL; REPERTOIRE; PATTERNS;
   AGE
AB Mice, similarly to some other rodent species, communicate with specialized sounds in the ultrasonic range called ultrasonic vocalizations (USV). Evaluation of this behavioral activity enables estimation of the social interactions in animal models of autistic spectrum disorders (ASD). Because transgenic mouse models are generated, in most cases, on the mixed 129SV/C57BL6 genetic background, we were interested if parameters that characterize USV differ between these two mouse strains. In addition, we wanted to compare these strains with the BALB/c line. In order to analyze USV, we applied the standard isolation test to newborn animals and compared standard parameters. Obtained results indicate clear differences between the 129SV and C57BL6 strains in respect to all analyzed USV parameters. Both strains behave also differently when compared with the BALB/c strain. For this reason in experiments utilizing transgenic animals, contribution of various genetic backgrounds has to be carefully considered.
C1 [Wiaderkiewicz, Jan; Glowacka, Marta; Grabowska, Marta; Barski, Jaroslaw-Jerzy] Med Univ Silesia, Ctr Med Expt, Katowice, Poland.
   [Wiaderkiewicz, Jan; Glowacka, Marta; Grabowska, Marta; Barski, Jaroslaw-Jerzy] Med Univ Silesia, Fac Med Katowice, Dept Physiol, Katowice, Poland.
RP Barski, JJ (reprint author), Med Univ Silesia, Ctr Med Expt, Katowice, Poland.
EM jbarski@sum.edu.pl
CR ATCHLEY WR, 1991, SCIENCE, V254, P554, DOI 10.1126/science.1948030
   BELL RW, 1972, BEHAV BIOL, V7, P805, DOI 10.1016/S0091-6773(72)80172-X
   ELWOOD RW, 1982, DEV PSYCHOBIOL, V15, P221, DOI 10.1002/dev.420150306
   HAHN ME, 1987, BEHAV GENET, V17, P155, DOI 10.1007/BF01065994
   Hahn ME, 1997, BEHAV GENET, V27, P133, DOI 10.1023/A:1025637408900
   Hahn ME, 1998, BEHAV GENET, V28, P315, DOI 10.1023/A:1021679615792
   Hofer M. A., 2002, CURR PROTOC NEUROSCI, V8, P14, DOI [DOI 10.1002/0471142301.NS0814S17, 10.1002/0471142301.ns0814s17.:Unit]
   Roubertoux PL, 1996, BEHAV GENET, V26, P427, DOI 10.1007/BF02359487
   Scattoni ML, 2008, BEHAV BRAIN RES, V187, P371, DOI 10.1016/j.bbr.2007.09.034
   Scattoni ML, 2013, BEHAV BRAIN RES, V251, P35, DOI 10.1016/j.bbr.2012.12.028
   Scattoni ML, 2010, HBK BEHAV NEUROSCI, V19, P89, DOI 10.1016/B978-0-12-374593-4.00010-3
   Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067
   Scattoni ML, 2009, NEUROSCI BIOBEHAV R, V33, P508, DOI 10.1016/j.neubiorev.2008.08.003
   Thornton LM, 2005, BEHAV GENET, V35, P73, DOI 10.1007/s10519-004-0857-4
   Young DM, 2010, P NATL ACAD SCI USA, V107, P11074, DOI 10.1073/pnas.1005620107
   Zippelius H. M., 1956, Naturwissenschaften, V43, P502
NR 16
TC 0
Z9 0
PU NENCKI INST EXPERIMENTAL BIOLOGY
PI WARSAW
PA UL PASTEURA 3, 02-093 WARSAW, POLAND
SN 0065-1400
EI 1689-0035
J9 ACTA NEUROBIOL EXP
JI Acta Neurobiol. Exp.
PY 2013
VL 73
IS 4
BP 557
EP 563
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 296RO
UT WOS:000330203300011
PM 24457645
ER

PT S
AU Martino, D
   Madhusudan, N
   Zis, P
   Cavanna, AE
AF Martino, Davide
   Madhusudan, Namrata
   Zis, Panagiotis
   Cavanna, Andrea E.
BE Martino, D
   Cavanna, AE
TI An Introduction to the Clinical Phenomenology of Tourette Syndrome
SO ADVANCES IN THE NEUROCHEMISTRY AND NEUROPHARMACOLOGY OF TOURETTE
   SYNDROME
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID OBSESSIVE-COMPULSIVE DISORDER; DEFICIT HYPERACTIVITY DISORDER; DEEP
   BRAIN-STIMULATION; QUALITY-OF-LIFE; ATTENTION-DEFICIT/HYPERACTIVITY
   DISORDER; AUTISM SPECTRUM DISORDERS; IMPULSE-CONTROL DISORDERS; GTS-QOL
   DEVELOPMENT; TIC DISORDERS; SENSORY PHENOMENA
AB Tourette syndrome (TS) is the primary tic disorder that reaches most commonly medical attention and monitoring, with an estimated prevalence close to 1% between 5 and 18 years of age. Motor and phonic tics are the core features of TS. In addition to their well-characterized phenomenology, tics display a peculiar variability overtime, which is strongly influenced by a variety of contextual factors. The sensory phenomena of TS are increasingly recognized as another crucial symptom of TS and consist of premonitory urges and somatic hypersensitivity. A relevant proportion of patients with TS display complex, tic-like, repetitive behaviors that include echophenomena, coprophenomena, and nonobscene socially inappropriate behaviors (NOSIBs). The burden of behavioral comorbidities is very important in determining the degree of disability of TS patients. Only a small minority of TS patients presents exclusively with a tic disorder. Obsessive-compulsive symptoms and related disorder (OCD) are common in TS, and the clinical distinction between compulsions and complex tics may be difficult in some cases. Probably, the presence of comorbid attention deficit hyperactivity disorder (ADHD) is the main determinant of cognitive dysfunction in TS patients and influences heavily also the risk of developing disruptive behaviors. Affective disorders, impulse control disorders, autism spectrum disorders, and personality disorders complete the wide psychopathological spectrum of this condition, but have been less investigated than OCD and ADHD. The complexity of the burette spectrum has been confirmed by cluster and factor analytical approaches, and is likely to inform the study of the genetic basis of this disorder, as well as future reappraisal of its nosography, with the development of novel clinical subtypes.
C1 [Martino, Davide] Queen Elizabeth Hosp, London, England.
   [Martino, Davide] Queen Mary Univ London, Ctr Neurosci & Trauma, London, England.
   [Martino, Davide; Zis, Panagiotis] Kings Coll Hosp London, London, England.
   [Madhusudan, Namrata; Cavanna, Andrea E.] Univ Birmingham, Dept Neuropsychiat, Birmingham, W Midlands, England.
   [Madhusudan, Namrata; Cavanna, Andrea E.] BSMHFT, Birmingham, W Midlands, England.
   [Cavanna, Andrea E.] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England.
   [Cavanna, Andrea E.] UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London, England.
RP Martino, D (reprint author), Queen Elizabeth Hosp, London, England.
EM davidemartino@nhs.net
CR Albin RL, 2006, TRENDS NEUROSCI, V29, P175, DOI 10.1016/j.tins.2006.01.001
   Alsobrook JP, 2002, AM J PSYCHIAT, V159, P291, DOI 10.1176/appi.ajp.159.2.291
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Banaschewski T, 2003, DEV MED CHILD NEUROL, V45, P700, DOI 10.1017/S0012162203001294
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   Belluscio BA, 2011, MOVEMENT DISORD, V26, P2538, DOI 10.1002/mds.23977
   Bernabei M, 2010, IEEE ENG MED BIO, P422, DOI 10.1109/IEMBS.2010.5627374
   Biermann-Ruben K, 2012, NEUROIMAGE, V63, P119, DOI 10.1016/j.neuroimage.2012.06.059
   Bloch MH, 2009, J AM ACAD CHILD PSY, V48, P884, DOI 10.1097/CHI.0b013e3181b26e9f
   Bloch Michael H, 2006, Arch Pediatr Adolesc Med, V160, P65, DOI 10.1001/archpedi.160.1.65
   Bloch MH, 2005, NEUROLOGY, V65, P1253, DOI 10.1212/01.wnl.0000180957.98702.69
   Bloch MH, 2006, J CHILD PSYCHOL PSYC, V47, P551, DOI 10.1111/j.1469-7610.2006.01561.x
   Braff DL, 2001, PSYCHOPHARMACOLOGY, V156, P234, DOI 10.1007/s002130100810
   Budman CL, 1998, J CLIN PSYCHIAT, V59, P576, DOI 10.4088/JCP.v59n1103
   Burd L, 2001, J CHILD NEUROL, V16, P431, DOI 10.1177/088307380101600609
   BURD L, 1986, J AM ACAD CHILD PSY, V25, P552, DOI 10.1016/S0002-7138(10)60016-7
   BURD L, 1984, ARCH NEUROL-CHICAGO, V41, P1236
   Burd Larry, 2005, BMC Pediatr, V5, P34, DOI 10.1186/1471-2431-5-34
   Carter AS, 2000, J CHILD PSYCHOL PSYC, V41, P215, DOI 10.1017/S0021963099005156
   Cath DC, 2011, EUR CHILD ADOLES PSY, V20, P155, DOI 10.1007/s00787-011-0164-6
   Cavanna A. E., 2012, J CHILD NEUROL, V28, P1305
   Cavanna AE, 2008, BRAIN DEV-JPN, V30, P308, DOI 10.1016/j.braindev.2007.08.012
   Cavanna AE, 2007, ACTA NEUROL SCAND, V116, P385, DOI 10.1111/j.1600-0404.2007.00879.x
   Cavanna AE, 2013, BEHAV NEUROL, V27, P95, DOI 10.3233/BEN-120274
   Cavanna AE, 2011, J NEUROL NEUROSUR PS, V82, P1320, DOI 10.1136/jnnp.2010.225029
   Cavanna AE, 2008, NEUROLOGY, V71, P1410, DOI 10.1212/01.wnl.0000327890.02893.61
   Cavanna AE, 2009, J NEUROPSYCH CLIN N, V21, P13, DOI 10.1176/appi.neuropsych.21.1.13
   Cavanna AE, 2012, EUR J PAEDIATR NEURO, V16, P605, DOI 10.1016/j.ejpn.2012.02.004
   Cavanna AE, 2009, WORLD J BIOL PSYCHIA, V10, P1037, DOI [10.1080/15622970802049767, 10.3109/15622970802049767]
   Cavanna AE, 2013, NEUROSCI BIOBEHAV R, V37, P1008, DOI 10.1016/j.neubiorev.2012.10.011
   Clarke RA, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.75
   COHEN AJ, 1992, J CLIN PSYCHIAT, V53, P319
   Cohen SC, 2013, NEUROSCI BIOBEHAV R, V37, P997, DOI 10.1016/j.neubiorev.2012.11.013
   Coles ME, 2003, BEHAV RES THER, V41, P681, DOI 10.1016/S0005-7967(02)00044-X
   COMINGS DE, 1987, AM J HUM GENET, V41, P701
   Conelea CA, 2008, J PSYCHOSOM RES, V65, P487, DOI 10.1016/j.jpsychores.2008.04.010
   Crossley E., 2013, BRAIN DEV       0128
   Cubo E, 2013, J PEDIATR-US, V163, P217, DOI 10.1016/j.jpeds.2012.12.030
   Debes NMMM, 2008, J CHILD NEUROL, V23, P1017, DOI 10.1177/0883073808316370
   Eapen V, 2004, ACTA NEUROL SCAND, V109, P255, DOI 10.1046/j.1600-0404.2003.00228.x
   Eapen Valsamma, 2008, Prim Care Companion J Clin Psychiatry, V10, P103
   Eddy Clare M, 2011, Ther Adv Neurol Disord, V4, P25, DOI 10.1177/1756285610390261
   Eddy CM, 2011, J NEUROL, V258, P291, DOI 10.1007/s00415-010-5754-6
   Eddy CM, 2011, MOVEMENT DISORD, V26, P735, DOI 10.1002/mds.23434
   Eddy CM, 2012, J NEUROPSYCH CLIN N, V24, P458, DOI 10.1176/appi.neuropsych.11080181
   Eddy CM, 2013, COMPR PSYCHIAT, V54, P105, DOI 10.1016/j.comppsych.2012.07.004
   Eddy CM, 2009, J PSYCHOSOM RES, V67, P503, DOI 10.1016/j.jpsychores.2009.08.001
   ERENBERG G, 1986, CLEV CLIN J MED, V53, P127
   Erenberg Gerald, 2005, Semin Pediatr Neurol, V12, P217, DOI 10.1016/j.spen.2005.12.003
   Felling RJ, 2011, J NEUROSCI, V31, P12387, DOI 10.1523/JNEUROSCI.0150-11.2011
   Fernandez TV, 2012, BIOL PSYCHIAT, V71, P392, DOI 10.1016/j.biopsych.2011.09.034
   Finis J, 2012, MOVEMENT DISORD, V27, P562, DOI 10.1002/mds.24913
   FISHER CM, 1988, NEUROLOGY, V38, P1868
   FORD RA, 1989, PSYCHOL MED, V19, P627
   Frank M, 2013, BEHAV NEUROL, V27, P105, DOI 10.3233/BEN-120309
   Frank MC, 2011, J NEUROL SCI, V310, P276, DOI 10.1016/j.jns.2011.06.032
   FRANKEL M, 1986, NEUROLOGY, V36, P378
   Freeman RD, 2009, DEV MED CHILD NEUROL, V51, P218, DOI 10.1111/j.1469-8749.2008.03135.x
   Freeman RD, 2000, DEV MED CHILD NEUROL, V42, P436, DOI 10.1017/S0012162200000839
   Ganos C, 2012, MOVEMENT DISORD, V27, P1222, DOI 10.1002/mds.25103
   Ganos C, 2012, J NEUROL NEUROSUR PS, V83, P975, DOI 10.1136/jnnp-2012-303033
   GEORGE MS, 1993, AM J PSYCHIAT, V150, P93
   Gillberg C, 2004, EUR CHILD ADOLES PSY, V13, P80, DOI 10.1007/s00787-004-1008-4
   Grados MA, 2008, BIOL PSYCHIAT, V64, P219, DOI 10.1016/j.biopsych.2008.01.019
   Gunther J, 2012, PSYCHIAT RES, V200, P593, DOI 10.1016/j.psychres.2012.04.034
   Hariz MI, 2010, EUR J NEUROSCI, V32, P1128, DOI 10.1111/j.1460-9568.2010.07415.x
   Hassan N, 2012, FUNCT NEUROL, V27, P23
   Jankovic J, 2001, NEW ENGL J MED, V345, P1184, DOI 10.1056/NEJMra010032
   Jankovic J, 1997, NEUROL CLIN, V15, P267, DOI 10.1016/S0733-8619(05)70311-X
   KANE MJ, 1994, J AM ACAD CHILD PSY, V33, P805, DOI 10.1097/00004583-199407000-00005
   Kano Y, 2008, CNS SPECTRUMS, V13, P325
   Kendler KS, 2006, AM J PSYCHIAT, V163, P109, DOI 10.1176/appi.ajp.163.1.109
   Khalifa N, 2003, DEV MED CHILD NEUROL, V45, P315, DOI 10.1017/S0012162203000598
   Khalifa Najah, 2005, Acta Paediatr, V94, P1608, DOI 10.1080/08035250510043879
   Kircanski K, 2010, J ABNORM CHILD PSYCH, V38, P777, DOI 10.1007/s10802-010-9410-5
   Kurlan R., 2013, TOURETTE SYNDROME, P395
   Kurlan R, 1996, J NEUROPSYCH CLIN N, V8, P311
   LANG AE, 1993, ANN NEUROL, V33, P212, DOI 10.1002/ana.410330212
   Leckman J. F., 1998, TOURETTES SYNDROME T, P23
   Leckman JF, 2013, TOURETTE SYNDROME, P3
   LECKMAN JF, 1993, AM J PSYCHIAT, V150, P98
   Leckman JF, 2002, LANCET, V360, P1577, DOI 10.1016/S0140-6736(02)11526-1
   Leckman JF, 1998, PEDIATRICS, V102, P14, DOI 10.1542/peds.102.1.14
   LECKMAN JF, 1994, AM J PSYCHIAT, V151, P675
   Lin HQ, 2007, J CHILD PSYCHOL PSYC, V48, P157, DOI 10.1111/j.1469-7610.2006.01687.x
   Lin HQ, 2010, BIOL PSYCHIAT, V67, P684, DOI 10.1016/j.biopsych.2009.08.020
   Lombroso PJ, 2008, BRAIN DEV-JPN, V30, P231, DOI 10.1016/j.braindev.2007.09.001
   Mariam N, 2012, J CHILD NEUROL, V27, P1250, DOI 10.1177/0883073811432887
   Mathews CA, 2007, BIOL PSYCHIAT, V61, P292, DOI 10.1016/j.biopsych.2006.02.009
   Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
   Miguel EC, 2003, J PSYCHOSOM RES, V55, P49, DOI 10.1016/S0022-3999(02)00583-4
   Miguel E C, 2001, Adv Neurol, V85, P43
   Montgomery M A, 1982, Adv Neurol, V35, P335
   Muller N, 1997, PSYCHIAT RES, V70, P105, DOI 10.1016/S0165-1781(97)02658-9
   Muller-Vahl KR, 2011, EUR CHILD ADOLES PSY, V20, P209, DOI 10.1007/s00787-011-0166-4
   Neal M., 2013, PSYCHIAT RES    0710
   Packer LE, 1997, NEUROL CLIN, V15, P457, DOI 10.1016/S0733-8619(05)70326-1
   Pappert EJ, 2003, NEUROLOGY, V61, P936
   PAULS DL, 1986, ARCH GEN PSYCHIAT, V43, P1180
   Peterson BS, 1998, BIOL PSYCHIAT, V44, P1337, DOI 10.1016/S0006-3223(98)00176-0
   Pick A, 1924, BRAIN, V47, P417, DOI 10.1093/brain/47.4.417
   Piedad J. C. P., 2012, NEUROSURGERY, V71, P173
   Porta M, 2009, NEUROLOGY, V73, P1375, DOI 10.1212/WNL.0b013e3181bd809b
   Prado HD, 2008, CNS SPECTRUMS, V13, P425
   Prado HD, 2007, CNS SPECTRUMS, V12, P95
   Pringsheim T, 2012, CAN J PSYCHIAT, V57, P133
   Rizzo R, 2013, EUR J PAEDIATR NEURO, V17, P421, DOI 10.1016/j.ejpn.2013.01.005
   Rizzo R, 2007, BRAIN DEV-JPN, V29, P413, DOI 10.1016/j.braindev.2006.12.003
   Rizzo R, 2012, BRAIN DEV-JPN, V34, P667, DOI 10.1016/j.braindev.2011.11.006
   ROBERTS JMA, 1989, J AUTISM DEV DISORD, V19, P271, DOI 10.1007/BF02211846
   ROBERTSON MM, 1988, BRIT J PSYCHIAT, V152, P383, DOI 10.1192/bjp.152.3.383
   Robertson MM, 1997, BRIT J PSYCHIAT, V171, P283, DOI 10.1192/bjp.171.3.283
   Robertson MM, 2006, EUR CHILD ADOLES PSY, V15, P1, DOI 10.1007/s00787-006-0505-z
   Robertson MM, 2007, PSYCHIAT GENET, V17, P143, DOI 10.1097/YPG.0b013e328015b937
   Robertson MM, 2007, NEUROCASE, V13, P446, DOI 10.1080/13554790802001395
   Robertson MM, 2006, J PSYCHOSOM RES, V61, P349, DOI 10.1016/j.jpsychores.2006.07.019
   Robertson MM, 1999, NEUROLOGY, V53, P2108
   Robertson MM, 2000, BRAIN, V123, P425, DOI 10.1093/brain/123.3.425
   Robertson MM, 2008, TOURETTE SYNDROME FA
   Roessner V, 2011, EUR CHILD ADOLES PSY, V20, P173, DOI 10.1007/s00787-011-0163-7
   Shapiro A.K., 1988, GILLES TOURETTE SYND
   Shapiro AK, 1978, GILLES TOURETTE SYND
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Simpson HA, 2011, CURR PSYCHIAT REP, V13, P351, DOI 10.1007/s11920-011-0223-1
   Singer HS, 2010, CURR TREAT OPTION NE, V12, P539, DOI 10.1007/s11940-010-0095-4
   Singer HS, 2005, LANCET NEUROL, V4, P149, DOI 10.1016/S1474-4422(05)01012-4
   Smith KRM, 2010, RES DEV DISABIL, V31, P1062, DOI 10.1016/j.ridd.2010.04.003
   Snijders AH, 2006, J NEUROL NEUROSUR PS, V77, P787, DOI 10.1136/jnnp.2005.084657
   SPENCER T, 1995, J AM ACAD CHILD PSY, V34, P1133, DOI 10.1097/00004583-199509000-00009
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   Steeves T, 2012, CAN J PSYCHIAT, V57, P144
   Storch EA, 2004, CHILD PSYCHIAT HUM D, V35, P107, DOI 10.1007/s10578-004-1880-7
   Sukhodolsky DG, 2003, J AM ACAD CHILD PSY, V42, P98, DOI 10.1097/01.CHI.0000024904.60748.3A
   Termine C, 2011, EUR J PAEDIATR NEURO, V15, P95, DOI 10.1016/j.ejpn.2011.01.002
   Verdellen C, 2011, EUR CHILD ADOLES PSY, V20, P197, DOI 10.1007/s00787-011-0167-3
   Waldon K., 2012, BEHAV NEUROL, V26, P265
   Woods DW, 2005, J DEV BEHAV PEDIATR, V26, P397, DOI 10.1097/00004703-200512000-00001
   Worbe Y, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012959
   Wright A, 2012, J NEUROPSYCH CLIN N, V24, P16, DOI 10.1176/appi.neuropsych.10010013
   ZAUSMER DM, 1954, ARCH DIS CHILD, V29, P537
NR 140
TC 3
Z9 3
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-411546-0
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 112
BP 1
EP 33
DI 10.1016/B978-0-12-411546-0.00001-9
PG 33
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA BJQ00
UT WOS:000329549300002
PM 24295616
ER

PT S
AU Paschou, P
   Fernandez, TV
   Sharp, F
   Heiman, GA
   Hoekstra, PJ
AF Paschou, Peristera
   Fernandez, Thomas V.
   Sharp, Frank
   Heiman, Gary A.
   Hoekstra, Pieter J.
BE Martino, D
   Cavanna, AE
TI Genetic Susceptibility and Neurotransmitters in Tourette Syndrome
SO ADVANCES IN THE NEUROCHEMISTRY AND NEUROPHARMACOLOGY OF TOURETTE
   SYNDROME
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID OBSESSIVE-COMPULSIVE DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
   TRYPTOPHAN HYDROXYLASE-2 GENE; DOPAMINE-D4 RECEPTOR LOCUS; SEROTONIN
   TRANSPORTER GENE; AUTISM SPECTRUM DISORDERS; HISTAMINE H-3; TIC
   SEVERITY; TRANSMISSION-DISEQUILIBRIUM; NEUROPSYCHIATRIC DISORDERS
AB Family studies have consistently shown that Tourette syndrome (TS) is a familial disorder and twin studies have clearly indicated a genetic contribution in the etiology of TS. Whereas early segregation studies of TS suggested a single-gene autosomal dominant disorder, later studies have pointed to more complex models including additive and multifactorial inheritance and likely interaction with genetic factors. While the exact cellular and molecular base of TS is as yet elusive, neuroanatomical and neurophysiological studies have pointed to the involvement of cortico-striato-thalamocortical circuits and abnormalities in dopamine, glutamate, gamma-aminobutyric acid, and serotonin neurotransmitter systems, with the most consistent evidence being available for involvement of dopamine-related abnormalities, that is, a reduction in tonic extracellular dopamine levels along with hyperresponsive spike-dependent dopamine release, following stimulation. Genetic and gene expression findings are very much supportive of involvement of these neurotransmitter systems. Moreover, intriguingly, genetic work on a two-generation pedigree has opened new research pointing to a role for histamine, a so far rather neglected neurotransmitter, with the potential of the development of new treatment options. Future studies should be aimed at directly linking neurotransmitter-related genetic and gene expression findings to imaging studies (imaging genetics), which enables a better understanding of the pathways and mechanisms through which the dynamic interplay of genes, brain, and environment shapes the TS phenotype.
C1 [Paschou, Peristera] Democritus Univ Thrace, Dept Mol Biol & Genet, Alexandroupolis, Greece.
   [Fernandez, Thomas V.] Yale Univ Sch Med, Ctr Child Study, New Haven, CT USA.
   [Sharp, Frank] Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA.
   [Sharp, Frank] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
   [Heiman, Gary A.] Rutgers State Univ, Dept Genet, Piscataway, NJ USA.
   [Hoekstra, Pieter J.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
RP Hoekstra, PJ (reprint author), Univ Groningen, Dept Psychiat, Univ Med Ctr Groningen, Groningen, Netherlands.
EM p.hoekstra@accare.nl
RI Fernandez, Thomas/D-4295-2009; Hoekstra, Pieter/O-4396-2014
OI Fernandez, Thomas/0000-0003-0830-022X; 
CR Adamczyk A, 2011, PSYCHIAT GENET, V21, P90, DOI 10.1097/YPG.0b013e328341a307
   ANDERSON GM, 1992, ARCH GEN PSYCHIAT, V49, P584
   Barr CL, 1996, AM J MED GENET, V67, P301, DOI 10.1002/(SICI)1096-8628(19960531)67:3<301::AID-AJMG6>3.0.CO;2-P
   Bloch M, 2011, CURR OPIN NEUROL, V24, P119, DOI 10.1097/WCO.0b013e328344648c
   Bolton D, 2007, PSYCHOL MED, V37, P39, DOI 10.1017/S0033291706008816
   Breedveld GJ, 2010, NEUROGENETICS, V11, P417, DOI 10.1007/s10048-010-0244-7
   Brioni JD, 2011, J PHARMACOL EXP THER, V336, P38, DOI 10.1124/jpet.110.166876
   Burd L, 2009, J CHILD NEUROL, V24, P170, DOI 10.1177/0883073808322666
   Canitano R, 2007, AUTISM, V11, P19, DOI 10.1177/1362361307070992
   Cavallini MC, 2000, PSYCHIAT RES, V97, P93, DOI 10.1016/S0165-1781(00)00220-1
   COMINGS DE, 1991, JAMA-J AM MED ASSOC, V266, P1793, DOI 10.1001/jama.266.13.1793
   Comings DE, 1996, AM J MED GENET, V67, P264, DOI 10.1002/(SICI)1096-8628(19960531)67:3<264::AID-AJMG4>3.0.CO;2-N
   COMINGS DE, 1990, AM J MED GENET, V36, P418, DOI 10.1002/ajmg.1320360410
   Craig AM, 2007, CURR OPIN NEUROBIOL, V17, P43, DOI 10.1016/j.conb.2007.01.011
   Crane J, 2011, AM J MED GENET B, V156B, P108, DOI 10.1002/ajmg.b.31134
   Curtis D, 2004, PSYCHIAT GENET, V14, P83, DOI 10.1097/01.ygp.0000107927.32051.f5
   Debes NMMM, 2010, EUR J MED GENET, V53, P171, DOI 10.1016/j.ejmg.2010.05.001
   Dehning S, 2010, PSYCHIAT GENET, V20, P35, DOI 10.1097/YPG.0b013e32833511ce
   Diaz-Anzaldua A, 2004, MOL PSYCHIATR, V9, P272, DOI 10.1038/sj.mp.4001411
   Ellender TJ, 2011, J NEUROSCI, V31, P15340, DOI 10.1523/JNEUROSCI.3144-11.2011
   Ercan-Sencicek AG, 2010, NEW ENGL J MED, V362, P1901, DOI 10.1056/NEJMoa0907006
   Faraone SV, 2005, BIOL PSYCHIAT, V57, P1313, DOI 10.1016/j.biopsych.2004.11.024
   Fernandez TV, 2012, BIOL PSYCHIAT, V71, P392, DOI 10.1016/j.biopsych.2011.09.034
   Ferrada C, 2008, NEUROPHARMACOLOGY, V55, P190, DOI 10.1016/j.neuropharm.2008.05.008
   First M. B., 1996, STRUCTURED CLIN INTE
   Gade R, 1998, MOL PSYCHIATR, V3, P50, DOI 10.1038/sj.mp.4000326
   GELERNTER J, 1994, ARCH NEUROL-CHICAGO, V51, P397
   Grice DE, 1996, AM J HUM GENET, V59, P644
   Gunther J, 2012, PSYCHIAT RES, V200, P593, DOI 10.1016/j.psychres.2012.04.034
   Guo Y, 2012, PSYCHIAT GENET, V22, P300, DOI 10.1097/YPG.0b013e32835862b1
   Haas HL, 2008, PHYSIOL REV, V88, P1183, DOI 10.1152/physrev.00043.2007
   Hebebrand J, 1997, AM J HUM GENET, V61, P238
   Herzberg I, 2010, PSYCHIAT GENET, V20, P179, DOI 10.1097/YPG.0b013e32833a215a
   HYDE TM, 1992, NEUROLOGY, V42, P652
   Ji WZ, 2008, NAT GENET, V40, P592, DOI 10.1038/ng.118
   Johansen CT, 2010, NAT GENET, V42, P684, DOI 10.1038/ng.628
   Karagiannidis I, 2013, J MED GENET, V50, P760, DOI 10.1136/jmedgenet-2013-101637
   Kataoka Y, 2010, J COMP NEUROL, V518, P277, DOI 10.1002/cne.22206
   Knight S, 2010, AM J MED GENET B, V153B, P656, DOI 10.1002/ajmg.b.31035
   Kubota Y, 2002, J NEUROCHEM, V83, P837, DOI 10.1046/j.1471-4159.2002.01189.x
   Laurin N, 2009, AM J MED GENET B, V150B, P95, DOI 10.1002/ajmg.b.30779
   Lawson-Yuen A, 2008, EUR J HUM GENET, V16, P614, DOI 10.1038/sj.ejhg.5202006
   Lebois EP, 2011, CURR TOP MED CHEM, V11, P648
   Leckman J. F., 1995, NEUROPSYCHOPHARMACOL, V12, P73
   Lee CC, 2005, PEDIATR NEUROL, V33, P272, DOI 10.1016/j.pediatrneurol.2005.05.005
   Lerner A, 2012, BRAIN, V135, P1926, DOI 10.1093/brain/aws104
   Lesch KP, 1996, SCIENCE, V274, P1527, DOI 10.1126/science.274.5292.1527
   Liao IH, 2010, PHARMACOGENOMICS, V11, P1733, DOI [10.2217/pgs.10.160, 10.2217/PGS.10.160]
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Lit L, 2008, J PSYCHIATR RES, V43, P319, DOI 10.1016/j.jpsychires.2008.03.012
   Lit L, 2007, AM J MED GENET B, V144B, P958, DOI 10.1002/ajmg.b.30550
   Liu SG, 2011, CNS NEUROSCI THER, V17, P793, DOI 10.1111/j.1755-5949.2011.00274.x
   Mathews CA, 2011, J AM ACAD CHILD PSY, V50, P46, DOI 10.1016/j.jaac.2010.10.004
   Merette C, 2000, AM J HUM GENET, V67, P1008, DOI 10.1086/303093
   Mossner R, 2007, MOL PSYCHIATR, V12, P617, DOI 10.1038/sj.mp.4002004
   Mossner R, 2006, INT J NEUROPSYCHOPH, V9, P437, DOI 10.1017/S1461145705005997
   Moya PR, 2013, MOVEMENT DISORD, V28, P1263, DOI 10.1002/mds.25460
   Munoz KE, 2009, J AM ACAD CHILD PSY, V48, P356, DOI 10.1097/CHI.0b013e31819aad07
   Munzar P, 2004, NEUROPSYCHOPHARMACOL, V29, P705, DOI 10.1038/sj.npp.1300380
   Nag A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059061
   NOTHEN MM, 1994, AM J MED GENET, V54, P249, DOI 10.1002/ajmg.1320540311
   Ohtsu H, 2001, FEBS LETT, V502, P53, DOI 10.1016/S0014-5793(01)02663-1
   O'Rourke JA, 2009, J PSYCHOSOM RES, V67, P533, DOI 10.1016/j.jpsychores.2009.06.006
   O'Rourke JA, 2011, AM J MED GENET B, V156B, P553, DOI 10.1002/ajmg.b.31195
   Ozbay F, 2006, AM J MED GENET B, V141B, P673, DOI 10.1002/ajmg.b.30393
   Pauls D. L., 1991, AM J HUM GENET, V48, P154
   PAULS DL, 1986, NEW ENGL J MED, V315, P993, DOI 10.1056/NEJM198610163151604
   PAULS DL, 1986, ARCH GEN PSYCHIAT, V43, P1177
   PAULS DL, 1995, AM J PSYCHIAT, V152, P76
   Poot M, 2010, NEUROGENETICS, V11, P81, DOI 10.1007/s10048-009-0205-1
   PRICE RA, 1985, ARCH GEN PSYCHIAT, V42, P815
   Rodenas-Cuadrado P., EUROPEAN J IN PRESS
   Rowe DC, 1998, BEHAV GENET, V28, P215, DOI 10.1023/A:1021427314941
   Seuchter SA, 2000, GENET EPIDEMIOL, V18, P33, DOI 10.1002/(SICI)1098-2272(200001)18:1<33::AID-GEPI3>3.0.CO;2-2
   Sharp FR, 2011, J CEREBR BLOOD F MET, V31, P1513, DOI 10.1038/jcbfm.2011.45
   SINGER HS, 1991, ANN NEUROL, V30, P558, DOI 10.1002/ana.410300408
   Singer HS, 2002, AM J PSYCHIAT, V159, P1329, DOI 10.1176/appi.ajp.159.8.1329
   State MW, 2011, CURR OPIN GENET DEV, V21, P302, DOI 10.1016/j.gde.2011.01.007
   Stewart SE, 2006, J AM ACAD CHILD PSY, V45, P1354, DOI 10.1097/01.chi.0000235075.25038.5a
   Swerdlow NR, 2001, BIOL PSYCHIAT, V50, P578, DOI 10.1016/S0006-3223(01)01164-7
   Tang Y, 2004, ANN NEUROL, V56, P808, DOI 10.1002/ana.20291
   Tarnok Z, 2007, AM J MED GENET B, V144B, P900, DOI 10.1002/ajmg.b.30517
   Tian YF, 2011, BRAIN RES, V1381, P228, DOI 10.1016/j.brainres.2011.01.026
   Tian YF, 2011, AM J MED GENET B, V156B, P72, DOI 10.1002/ajmg.b.31140
   Tian YF, 2012, BMC MED GENOMICS, V5, DOI 10.1186/1755-8794-5-49
   Verkerk AJMH, 2006, MOL PSYCHIATR, V11, P954, DOI 10.1038/sj.mp.4001877
   Verkerk AJMH, 2003, GENOMICS, V82, P1, DOI 10.1016/S0888-7543(03)00097-1
   Voyiaziakis E, 2011, MOL PSYCHIATR, V16, P108, DOI 10.1038/mp.2009.100
   Walkup JT, 1996, AM J HUM GENET, V59, P684
   Walther DJ, 2003, SCIENCE, V299, P76, DOI 10.1126/science.1078197
   Wang ZS, 2011, AM J PSYCHIAT, V168, P1326, DOI 10.1176/appi.ajp.2011.09111692
   Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104
   Wong DF, 2008, NEUROPSYCHOPHARMACOL, V33, P1239, DOI 10.1038/sj.npp.1301528
   Wu Ke, 2012, Pharmacol Biochem Behav, V100, P726, DOI 10.1016/j.pbb.2011.10.007
   Xu XH, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-10
   Yoon DY, 2007, AM J MED GENET B, V144B, P605, DOI 10.1002/ajmg.b.30466
   Young SE, 2002, AM J MED GENET, V114, P144, DOI 10.1002/ajmg.10155
NR 97
TC 2
Z9 2
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-411546-0
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 112
BP 155
EP 177
DI 10.1016/B978-0-12-411546-0.00006-8
PG 23
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA BJQ00
UT WOS:000329549300007
PM 24295621
ER

PT J
AU Daud, MKM
   Noor, SSM
   Yusoff, MNCM
   Abd Rahman, N
   Zakaria, MN
AF Daud, M. K. Md
   Noor, S. S. M.
   Yusoff, M. N. C. M.
   Abd Rahman, N.
   Zakaria, M. N.
TI Gender differences in coping skills of parents with hearing-impaired
   children
SO B-ENT
LA English
DT Article
DE Hearing loss; sensorineural; coping skills; gender; parents
ID MOTHERS; SPIRITUALITY; STRATEGIES; INFANTS; AUTISM
AB Objective: To assess differences between the coping strategies of the mothers and fathers with hearing-impaired children.
   Methodology: A cross-sectional study was conducted looking at parents of children with moderate to profound hearing impairment. The parents with more than one child with a hearing impairment, the parents of children with additional disabilities and syndromes, single parents, and parents with their own hearing impairments were excluded from the study. A Brief COPE Scale questionnaire translated into Malay was used to assess the coping strategies. The questionnaire includes 28 items and was rated using a four-point Likert scale. Independent t-testing was used to compare the coping strategies of mothers and fathers. Simple linear regression was used to determine the association between age and coping strategies.
   Results: There were 72 participants. The number of mothers and fathers was equal. Religion, active coping and acceptance were the highest three scores in the domains, while substance use and behavioural disengagement were least used in both groups. The domains of religion, seeking emotional support and seeking instrumental support scored significantly higher in mothers than in fathers (p<0.05). There was a significant difference between the two groups in terms of problem-focused strategies (p = 0.016) but not in terms of emotional-focused strategies (p = 0.134). There were significant negative linear correlations between age and seeking emotional support, humour and instrumental support (p<0.05).
   Conclusion: There were gender differences in the coping strategies among parents with hearing-impaired children. These are important factors that should be considered when counselling and establishing support groups for the parents of these children.
C1 [Daud, M. K. Md] Univ Sains Malaysia, Sch Med Sci, Dept Otorhinolaryngol, Kubang Kerian 16150, Kelantan, Malaysia.
   [Yusoff, M. N. C. M.] Univ Sains Malaysia, Sch Med Sci, Dept Neurosci, Kubang Kerian 16150, Kelantan, Malaysia.
   [Noor, S. S. M.; Zakaria, M. N.] Univ Sains Malaysia, Sch Hlth Sci, Kubang Kerian 16150, Kelantan, Malaysia.
   [Abd Rahman, N.] Univ Sains Malaysia, Sch Dent Sci, Kubang Kerian 16150, Kelantan, Malaysia.
RP Daud, MKM (reprint author), Univ Sains Malaysia, Sch Med Sci, Dept Otorhinolaryngol Head & Neck Surg, Hlth Campus, Kubang Kerian 16150, Kelantan, Malaysia.
EM khairi@kck.usm.my
CR Austenfeld JL, 2004, J PERS, V72, P1335, DOI 10.1111/j.1467-6494.2004.00299.x
   Azar R, 2001, J Pediatr Nurs, V16, P418, DOI 10.1053/jpdn.2001.27878
   Broger B, 2011, J PEDIATR HEALTH CAR, V25, P96, DOI 10.1016/j.pedhc.2009.09.004
   Bussing A, 2007, INT J PSYCHIAT MED, V37, P39, DOI 10.2190/60W7-1661-2623-6042
   Cunningham M, 2003, PEDIATRICS, V111, P436, DOI 10.1542/peds.111.2.436
   Ekas NV, 2009, J AUTISM DEV DISORD, V39, P706, DOI 10.1007/s10803-008-0673-4
   Fontana A, 1998, BEHAV MED, V24, P5
   Glidden LM, 2006, J INTELL DISABIL RES, V50, P949, DOI 10.1111/j.1365-2788.2006.00929.x
   Hastings RP, 2005, AUTISM, V9, P377, DOI 10.1177/1362361305056078
   Heaman D J, 1995, J Pediatr Nurs, V10, P311, DOI 10.1016/S0882-5963(05)80049-1
   Hintermair Manfred, 2004, J Deaf Stud Deaf Educ, V9, P15, DOI 10.1093/deafed/enh005
   Hoekstra-Weebers JEHM, 1998, PSYCHO-ONCOL, V7, P26, DOI 10.1002/(SICI)1099-1611(199801/02)7:1<26::AID-PON315>3.0.CO;2-0
   Kemper AR, 2000, ARCH PEDIAT ADOL MED, V154, P484
   Khairi M, 2005, J LARYNGOL OTOL, V119, P678
   Khairi MDM, 2011, INT J PEDIATR OTORHI, V75, P513, DOI 10.1016/j.ijporl.2011.01.009
   Mednick L, 2009, J UROLOGY, V181, P1312, DOI 10.1016/j.juro.2008.10.051
   Khairi MDM, 2009, SINGAP MED J, V50, pE324
   Speleman K, 2012, B-ENT, V8, P1
   Sullivan A, 2002, SYNDROME RES PRACTIC, V8, P67
   Yusoff N, 2009, MJP ONLINE, V18, P1
NR 20
TC 0
Z9 0
PU ROYAL BELGIAN SOC EAR, NOSE, THROAT, HEAD & NECK SURGERY
PI LEUVEN
PA PO BOX 1248, LEUVEN, 00000, BELGIUM
SN 0001-6497
J9 B-ENT
JI B-ENT
PY 2013
VL 9
IS 4
BP 319
EP 323
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 297NK
UT WOS:000330262000010
ER

PT S
AU Sapede, D
   Cau, E
AF Sapede, Dora
   Cau, Elise
BE Thomas, P
TI The Pineal Gland from Development to Function
SO ENDOCRINE GLAND DEVELOPMENT AND DISEASE
SE Current Topics in Developmental Biology
LA English
DT Review; Book Chapter
ID SMITH-MAGENIS-SYNDROME; PHOTORECEPTOR CONSERVED ELEMENTS; LEFT-RIGHT
   ASYMMETRY; TALPA-EUROPAEA L; BREAST-CANCER; MELATONIN SUPPRESSION;
   ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CIRCADIAN CLOCK; GENE-EXPRESSION
AB The pineal gland is a small neuroendocrine organ whose main and most conserved function is the nighttime secretion of melatonin. In lower vertebrates, the pineal gland is directly photosensitive. In contrast, in higher vertebrates, the direct photosensitivity of the pineal gland had been lost. Rather, the action of this gland as a relay between environmental light conditions and body functions involves reception of light information by the retina. In parallel to this sensory regression, the pineal gland (and its accessory organs) appears to have lost several functions in relation to light and temperature, which are important in lower vertebrate species. In humans, the functions of the pineal gland overlap with the functions of melatonin. They are extremely widespread and include general effects both on cell protection and on more precise functions, such as sleep and immunity. Recently, the role of melatonin has received a considerable amount of attention due to increased cancer risk in shift workers and the discovery that patients suffering from neurodegenerative diseases, autism, or depression exhibit abnormal melatonin rhythms.
C1 [Sapede, Dora; Cau, Elise] Univ Toulouse, UPS, CBD, Toulouse, France.
   [Sapede, Dora; Cau, Elise] CNRS, CBD UMR 5547, Toulouse, France.
RP Cau, E (reprint author), Univ Toulouse, UPS, CBD, Toulouse, France.
EM elise.cau@univ-tlse3.fr
CR Acuna-Castroviejo D., 1997, LIFE SCI, V60, pL23
   Adi N., 2010, MED SCI MONITOR, V16, pBR61
   AMES BN, 1993, P NATL ACAD SCI USA, V90, P7915, DOI 10.1073/pnas.90.17.7915
   Antolin I, 2002, BRAIN RES, V943, P163, DOI 10.1016/S0006-8993(02)02551-9
   Appelbaum L, 2005, J BIOL CHEM, V280, P11544, DOI 10.1074/jbc.M412935200
   Appelbaum L, 2006, MOL CELL ENDOCRINOL, V252, P27, DOI 10.1016/j.mce.2006.03.021
   Appelbaum L, 2004, MOL ENDOCRINOL, V18, P1210, DOI 10.1210/me.2003-0439
   ARAKI M, 1992, DEV BIOL, V149, P440, DOI 10.1016/0012-1606(92)90298-U
   Asaoka Y, 2002, P NATL ACAD SCI USA, V99, P15456, DOI 10.1073/pnas.232444199
   Bailey MJ, 2005, MOL BRAIN RES, V134, P345, DOI 10.1016/j.molbrainres.2004.11.003
   Barth KA, 1999, DEVELOPMENT, V126, P4977
   BECKERANDRE M, 1994, J BIOL CHEM, V269, P28531
   Beskonakli E, 2001, NEUROSURG REV, V24, P26, DOI 10.1007/PL00011962
   Blackshaw S, 1997, J NEUROSCI, V17, P8083
   Blask DE, 2003, BREAST CANCER RES TR, V79, P313, DOI 10.1023/A:1024030518065
   Blickenstaff R T, 1994, Bioorg Med Chem, V2, P1057, DOI 10.1016/S0968-0896(00)82055-6
   Borbély A A, 1982, Hum Neurobiol, V1, P195
   Bordet R, 2003, CLIN NEUROPHARMACOL, V26, P65, DOI 10.1097/00002826-200303000-00005
   Brainard GC, 2001, J NEUROSCI, V21, P6405
   BREDER CM, 1950, SCIENCE, V111, P10, DOI 10.1126/science.111.2871.10
   Bubenik GA, 2002, DIGEST DIS SCI, V47, P2336, DOI 10.1023/A:1020107915919
   Carpizo R, 2006, J PEDIATR-US, V149, P409, DOI 10.1016/j.jpeds.2006.04.055
   CARSKADON MA, 1982, NEUROBIOL AGING, V3, P321, DOI 10.1016/0197-4580(82)90020-3
   Cau E, 2003, DEVELOPMENT, V130, P2455, DOI 10.1242/dev.00452
   Cau E, 2009, NEURAL DEV, V4, DOI 10.1186/1749-8104-4-36
   Cau E, 2008, DEVELOPMENT, V135, P2391, DOI 10.1242/dev.013482
   Cermakian N, 2000, P NATL ACAD SCI USA, V97, P4339, DOI 10.1073/pnas.97.8.4339
   Chaudhury D, 2002, BEHAV BRAIN RES, V133, P95, DOI 10.1016/S0166-4328(01)00471-5
   Chaurasia SS, 2005, J NEUROCHEM, V92, P158, DOI 10.1111/j.1471-4159.2004.02874.x
   Clanton JA, 2013, DEVELOPMENT, V140, P323, DOI 10.1242/dev.083709
   Concha ML, 2001, J ANAT, V199, P63, DOI 10.1046/j.1469-7580.2001.19910063.x
   Concha ML, 2003, NEURON, V39, P423, DOI 10.1016/S0896-6273(03)00437-9
   Costa EJX, 1995, J PINEAL RES, V19, P123, DOI 10.1111/j.1600-079X.1995.tb00180.x
   CSABA G, 1975, ENDOCRINOL EXP, V9, P59
   Danilova N, 2004, FASEB J, V18, P751, DOI 10.1096/fj.03-0544fje
   Dauchy RT, 1997, LAB ANIM SCI, V47, P511
   Dauchy RT, 1999, CANCER LETT, V144, P131, DOI 10.1016/S0304-3835(99)00207-4
   D'Autilia S, 2010, P NATL ACAD SCI USA, V107, P6352, DOI 10.1073/pnas.1000854107
   de Borsetti NH, 2011, DEV BIOL, V358, P251, DOI 10.1016/j.ydbio.2011.07.038
   De Leersnyder H, 2006, MOL CELL ENDOCRINOL, V252, P88, DOI 10.1016/j.mce.2006.03.043
   Doi M, 2001, P NATL ACAD SCI USA, V98, P8089, DOI 10.1073/pnas.141090998
   Dubocovich ML, 1999, ADV EXP MED BIOL, V460, P181
   Dufourcq P, 2004, GENE EXPR PATTERNS, V4, P53, DOI 10.1016/S1567-133X(03)00148-0
   DYKENS JA, 1987, J NEUROCHEM, V49, P1222, DOI 10.1111/j.1471-4159.1987.tb10014.x
   EDGAR DM, 1993, J NEUROSCI, V13, P1065
   EKSTROM P, 1988, NEUROSCIENCE, V25, P1061, DOI 10.1016/0306-4522(88)90059-0
   Ekstrom P, 2003, PHILOS T ROY SOC B, V358, P1679, DOI 10.1098/rstb.2003.1303
   ENGBRETSON GA, 1991, J COMP NEUROL, V314, P799, DOI 10.1002/cne.903140412
   ENGBRETSON GA, 1990, VISUAL NEUROSCI, V5, P395
   ENGBRETSON GA, 1976, J EXP ZOOL, V198, P29, DOI 10.1002/jez.1401980105
   Estivill-Torrus G, 2001, MECH DEVELOP, V109, P215, DOI 10.1016/S0925-4773(01)00527-5
   FALCON J, 1981, J COMP PHYSIOL, V144, P127
   Fernandes AM, 2012, CURR BIOL, V22, P2042, DOI 10.1016/j.cub.2012.08.016
   FIRTH BT, 1980, NATURE, V285, P399, DOI 10.1038/285399a0
   Flynn-Evans EE, 2009, CANCER CAUSE CONTROL, V20, P1753, DOI 10.1007/s10552-009-9405-0
   Forsell J, 2001, J EXP BIOL, V204, P2517
   FOSTER RG, 1982, J COMP PHYSIOL, V145, P413
   Frigato E, 2006, NATURWISSENSCHAFTEN, V93, P379, DOI 10.1007/s00114-006-0119-9
   Furukawa T, 1999, NAT GENET, V23, P466, DOI 10.1038/70591
   Gamse JT, 2003, DEVELOPMENT, V130, P1059, DOI 10.1242/dev.00270
   Gamse JT, 2002, NAT GENET, V30, P117, DOI 10.1038/ng793
   Ganguly S, 2001, P NATL ACAD SCI USA, V98, P8083, DOI 10.1073/pnas.141118798
   Ganguly S, 2005, P NATL ACAD SCI USA, V102, P1222, DOI 10.1073/pnas.0406871102
   GUNDY GC, 1975, SCIENCE, V190, P671, DOI 10.1126/science.1237930
   Hansen J, 2001, J NATL CANCER I, V93, P1513
   Hardeland R, 2003, J PINEAL RES, V34, P233
   Hardeland R, 2012, J PINEAL RES, V52, P139, DOI 10.1111/j.1600-079X.2011.00934.x
   HARMAN D, 1994, ANN NY ACAD SCI, V717, P1, DOI 10.1111/j.1749-6632.1994.tb12069.x
   HARMAN D, 1993, DRUG AGING, V3, P60, DOI 10.2165/00002512-199303010-00006
   Haupt Ygal, 1997, Leukemia (Basingstoke), V11, P337
   Hofman MA, 2000, CHRONOBIOL INT, V17, P245, DOI 10.1081/CBI-100101047
   HUANG SK, 1992, CELL TISSUE RES, V267, P493, DOI 10.1007/BF00319371
   Hughes RJ, 1997, SLEEP, V20, P124
   Jamieson D, 2000, J EXP BIOL, V203, P1857
   JENGELESKI CA, 1989, BRAIN RES, V481, P378, DOI 10.1016/0006-8993(89)90818-4
   Karolczak M, 2005, ENDOCRINE, V27, P89, DOI 10.1385/ENDO:27:2:089
   Kliukiene J, 2001, BRIT J CANCER, V84, P397, DOI 10.1054/bjoc.2000.1617
   KORF HW, 1992, ACTA NEUROPATHOL, V83, P482
   Koyanagi M, 2004, P NATL ACAD SCI USA, V101, P6687, DOI 10.1073/pnas.0400819101
   Krauss A, 2003, VISION RES, V43, P1273, DOI 10.1016/S0042-6989(03)00090-7
   Kulman G, 2000, NEUROENDOCRINOL LETT, V21, P31
   Kunz D, 1999, NEUROPSYCHOPHARMACOL, V21, P765, DOI 10.1016/S0893-133X(99)00069-X
   KUSMIC C, 1993, MICRON, V24, P279, DOI 10.1016/0968-4328(93)90054-5
   Lahti T, 2012, ANN MED, V44, P847, DOI 10.3109/07853890.2012.727018
   Lavie P, 1997, J BIOL RHYTHM, V12, P657, DOI 10.1177/074873049701200622
   LEWY AJ, 1980, J CLIN ENDOCR METAB, V50, P204
   Lincoln G, 2002, P NATL ACAD SCI USA, V99, P13890, DOI 10.1073/pnas.212517599
   Liu C, 1997, NEURON, V19, P91, DOI 10.1016/S0896-6273(00)80350-5
   Lyssenko V, 2009, NAT GENET, V41, P82, DOI 10.1038/ng.288
   MACHADO CRS, 1969, SCIENCE, V164, P442, DOI 10.1126/science.164.3878.442
   Mano H, 2007, PHOTOCHEM PHOTOBIOL, V83, P11, DOI 10.1562/2006-02-24-IR-813
   Mano H, 1999, MOL BRAIN RES, V73, P110, DOI 10.1016/S0169-328X(99)00242-9
   MARCHIAFAVA PL, 1993, PROG BRAIN RES, V95, P3, DOI 10.1016/S0079-6123(08)60352-0
   Maronde E, 2007, TRENDS ENDOCRIN MET, V18, P142, DOI 10.1016/j.tem.2007.03.001
   Masai I, 1997, NEURON, V18, P43, DOI 10.1016/S0896-6273(01)80045-3
   McCurry SM, 2011, J AM GERIATR SOC, V59, P1393, DOI 10.1111/j.1532-5415.2011.03519.x
   Mediavilla MD, 1999, LIFE SCI, V65, P415, DOI 10.1016/S0024-3205(99)00262-3
   MEINIEL A, 1980, CELL TISSUE RES, V207, P407
   MEINIEL A, 1976, J NEURAL TRANSM, V39, P139, DOI 10.1007/BF01248772
   MEISSL H, 1986, COMP BIOCHEM PHYS A, V84, P467, DOI 10.1016/0300-9629(86)90350-6
   Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016
   MENDELSON WB, 1980, BRAIN RES, V201, P240, DOI 10.1016/0006-8993(80)90793-3
   MENENDEZPELAEZ A, 1993, J PINEAL RES, V15, P59, DOI 10.1111/j.1600-079X.1993.tb00511.x
   Mishima K, 2001, J CLIN ENDOCR METAB, V86, P129, DOI 10.1210/jc.86.1.129
   Møller M, 1979, Prog Brain Res, V52, P103, DOI 10.1016/S0079-6123(08)62915-5
   Moller M, 2002, CELL TISSUE RES, V309, P139, DOI 10.1007/s00441-002-0580-5
   Moller M, 1997, BIOL CELL, V89, P561, DOI 10.1016/S0248-4900(98)80160-3
   MOORE RY, 1988, BRAIN RES, V457, P395, DOI 10.1016/0006-8993(88)90715-9
   MORRIS M, 1990, J PINEAL RES, V9, P133, DOI 10.1111/j.1600-079X.1990.tb00701.x
   Muller HL, 2002, J CLIN ENDOCR METAB, V87, P3993, DOI 10.1210/jc.87.8.3993
   Murphy PJ, 1996, J CLIN NEUROPHYSIOL, V13, P2, DOI 10.1097/00004691-199601000-00002
   Nelson RJ, 1996, Q REV BIOL, V71, P511, DOI 10.1086/419555
   Neuhauss SCF, 1999, J NEUROSCI, V19, P8603
   Nir I, 1995, J AUTISM DEV DISORD, V25, P641, DOI 10.1007/BF02178193
   Nishida A, 2003, NAT NEUROSCI, V6, P1255, DOI 10.1038/nn1155
   Nishio SI, 2008, MOL ENDOCRINOL, V22, P23, DOI 10.1210/me.2007-0170
   NORDLUND JJ, 1977, J CLIN ENDOCR METAB, V45, P768
   Nosjean O, 2000, J BIOL CHEM, V275, P31311, DOI 10.1074/jbc.M005141200
   OKSCHE A, 1965, Prog Brain Res, V10, P3
   Oren M, 2003, CELL DEATH DIFFER, V10, P431, DOI 10.1038/sj.cdd.4401183
   Pandi-Perumal SR, 2008, PROG NEUROBIOL, V85, P335, DOI 10.1016/j.pneurobio.2008.04.001
   Pappolla MA, 2000, J NEURAL TRANSM, V107, P203, DOI 10.1007/s007020050018
   PERENTES E, 1986, ACTA NEUROPATHOL, V71, P224
   Peschke E, 2002, J PINEAL RES, V33, P63, DOI 10.1034/j.1600-079X.2002.02919.x
   PEVET P, 1977, J NEURAL TRANSM, V40, P47, DOI 10.1007/BF01250280
   PEVET P, 1976, J ULTRA MOL STRUCT R, V57, P22, DOI 10.1016/S0022-5320(76)80051-2
   PEVET P, 1980, CELL TISSUE RES, V206, P417
   PHILLIPS JA, 1988, PHYSIOL BEHAV, V42, P103, DOI 10.1016/0031-9384(88)90268-5
   Pierce LX, 2008, BRAIN RES, V1223, P11, DOI 10.1016/j.brainres.2008.05.020
   Plouhinec JL, 2004, GENE EXPR PATTERNS, V5, P11, DOI 10.1016/j.modgep.2004.06.010
   Plouhinec JL, 2003, MOL BIOL EVOL, V20, P513, DOI 10.1093/molbev/msg085
   POEGGELER B, 1993, EXPERIENTIA, V49, P611, DOI 10.1007/BF01923940
   Poirel VJ, 2003, NEUROSCIENCE, V120, P745, DOI 10.1016/S0306-4522(03)00344-0
   QUAY W B, 1965, Prog Brain Res, V10, P49
   Quillien A, 2011, DEVELOPMENT, V138, P2293, DOI 10.1242/dev.060988
   Rawashdeh O, 2012, FRONT MOL NEUROSCI, V5, DOI 10.3389/fnmol.2012.00027
   Rawashdeh O, 2007, SCIENCE, V318, P1144, DOI 10.1126/science.1148564
   Regan JC, 2009, NEURON, V61, P27, DOI 10.1016/j.neuron.2008.11.030
   Reid K, 1996, J SLEEP RES, V5, P150, DOI 10.1046/j.1365-2869.1996.t01-1-00006.x
   Reiter R J, 1980, Endocr Rev, V1, P109
   REITER RJ, 1991, MOL CELL ENDOCRINOL, V79, pC153, DOI 10.1016/0303-7207(91)90087-9
   Reiter RJ, 2002, NEUROENDOCRINOL LETT, V23, P9
   REITER RJ, 1992, CHRONOBIOL INT, V9, P314, DOI 10.3109/07420529209064541
   REPPERT SM, 1994, NEURON, V13, P1177, DOI 10.1016/0896-6273(94)90055-8
   Reppert SM, 1996, TRENDS PHARMACOL SCI, V17, P100, DOI 10.1016/0165-6147(96)10005-5
   REPPERT SM, 1995, P NATL ACAD SCI USA, V92, P8734, DOI 10.1073/pnas.92.19.8734
   Roussigne M, 2009, DEVELOPMENT, V136, P1549, DOI 10.1242/dev.034793
   Sakai K, 2012, BIOCHEMISTRY-US, V51, P1933, DOI 10.1021/bi2018283
   Santoro R, 2012, ONCOGENE, V31, P2931, DOI 10.1038/onc.2011.469
   Sauer LA, 1997, J NUTR, V127, P1412
   Schernhammer ES, 2006, EPIDEMIOLOGY, V17, P108, DOI 10.1097/01.ede.0000190539.03500.c1
   Schernhammer ES, 2001, J NATL CANCER I, V93, P1563
   Schernhammer ES, 2008, J NATL CANCER I, V100, P898, DOI 10.1093/jnci/djn171
   SCHMID HA, 1993, GERONTOLOGY, V39, P189
   Senthilan PR, 2012, CELL, V150, P1042, DOI 10.1016/j.cell.2012.06.043
   Shen WL, 2011, SCIENCE, V331, P1333, DOI 10.1126/science.1198904
   Shiraki T, 2010, PHOTOCH PHOTOBIO SCI, V9, P1498, DOI 10.1039/c0pp00199f
   Sigurdardottir LG, 2012, CANCER EPIDEM BIOMAR, V21, P1002, DOI 10.1158/1055-9965.EPI-12-0116
   SKENE DJ, 1990, BRAIN RES, V528, P170, DOI 10.1016/0006-8993(90)90214-V
   Slominski A, 2008, TRENDS ENDOCRIN MET, V19, P17, DOI 10.1016/j.tem.2007.10.007
   Snelson CD, 2008, DEVELOPMENT, V135, P1693, DOI 10.1242/dev.016576
   Srinivasan V, 2005, Immun Ageing, V2, P17, DOI 10.1186/1742-4933-2-17
   Staiger H, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003962
   Stehle JH, 2011, J PINEAL RES, V51, P17, DOI 10.1111/j.1600-079X.2011.00856.x
   Stoykova A, 1996, DEVELOPMENT, V122, P3453
   Su CY, 2006, SCIENCE, V311, P1617, DOI 10.1126/science.1123802
   Takanaka Y, 1998, J NEUROCHEM, V70, P908
   Takanaka Y, 2002, J NEUROSCI, V22, P4357
   Tan DX, 2003, J PINEAL RES, V34, P75, DOI 10.1034/j.1600-079X.2003.02111.x
   TAN DX, 1994, CARCINOGENESIS, V15, P215, DOI 10.1093/carcin/15.2.215
   TAN DX, 1993, CANCER LETT, V70, P65, DOI 10.1016/0304-3835(93)90076-L
   Tansey MG, 2007, EXP NEUROL, V208, P1, DOI 10.1016/j.expneurol.2007.07.004
   Thapan K, 2001, J PHYSIOL-LONDON, V535, P261, DOI 10.1111/j.1469-7793.2001.t01-1-00261.x
   Tordjman S, 2005, BIOL PSYCHIAT, V57, P134, DOI 10.1016/j.biopsych.2004.11.003
   Tynes T, 1996, CANCER CAUSE CONTROL, V7, P197, DOI 10.1007/BF00051295
   TZISCHINSKY O, 1994, SLEEP, V17, P638
   UNDERWOOD H, 1987, Journal of Biological Rhythms, V2, P195, DOI 10.1177/074873048700200303
   Unger T, 1999, EMBO J, V18, P1805, DOI 10.1093/emboj/18.7.1805
   Vatine G, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000223
   Vatine G, 2011, FEBS LETT, V585, P1485, DOI 10.1016/j.febslet.2011.04.007
   VIGH B, 1993, ARCH HISTOL CYTOL, V56, P485, DOI 10.1679/aohc.56.485
   Vigh B, 2002, HISTOL HISTOPATHOL, V17, P555
   VIGHTEICHMANN I, 1989, EXP BIOL, V48, P203
   Wada S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039003
   WEAVER DR, 1993, J CLIN ENDOCR METAB, V76, P295, DOI 10.1210/jc.76.2.295
   Whitmore D, 1998, NAT NEUROSCI, V1, P701
   WIESENBERG I, 1995, NUCLEIC ACIDS RES, V23, P327, DOI 10.1093/nar/23.3.327
   Williams SR, 2012, AM J HUM GENET, V90, P941, DOI 10.1016/j.ajhg.2012.04.013
   WILSON BW, 1978, LIFE SCI, V23, P1019, DOI 10.1016/0024-3205(78)90661-6
   WILSON SW, 1991, DEVELOPMENT, V112, P723
   WILSON SW, 1990, DEVELOPMENT, V108, P121
   Wyatt JK, 2006, SLEEP, V29, P609
   Yoshizawa M, 2008, J EXP BIOL, V211, P292, DOI 10.1242/jeb.012864
   Zawilska JB, 2000, J PINEAL RES, V29, P1, DOI 10.1034/j.1600-079X.2000.290101.x
   Zeitzer JM, 2000, J CLIN ENDOCR METAB, V85, P2189, DOI 10.1210/jc.85.6.2189
   Zhang C, 2010, P NATL ACAD SCI USA, V107, P20164, DOI 10.1073/pnas.1014941107
   Zhang J, 1999, AM J PATHOL, V154, P1423, DOI 10.1016/S0002-9440(10)65396-5
   ZHDANOVA IV, 1995, CLIN PHARMACOL THER, V57, P552, DOI 10.1016/0009-9236(95)90040-3
   Ziv L, 2007, EXP EYE RES, V84, P92, DOI 10.1016/j.exer.2006.09.004
NR 199
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0070-2153
BN 978-0-12-416021-7
J9 CURR TOP DEV BIOL
JI Curr. Top. Dev. Biol.
PY 2013
VL 106
BP 171
EP 215
DI 10.1016/B978-0-12-416021-7.00005-5
PG 45
WC Developmental Biology
SC Developmental Biology
GA BJQ44
UT WOS:000329678700006
PM 24290350
ER

PT J
AU Andrade, C
AF Andrade, Chittaranjan
TI Antidepressant Use in Pregnancy and Risk of Autism Spectrum Disorders: A
   Critical Examination of the Evidence
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Editorial Material
C1 Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataki, India.
RP Andrade, C (reprint author), Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataki, India.
EM candrade@psychiatrist.com
CR Andrade Chittaranjan, 2011, Indian J Psychiatry, V53, P362, DOI 10.4103/0019-5545.91912
   Croen LA, 2011, ARCH GEN PSYCHIAT, V68, P1104, DOI 10.1001/archgenpsychiatry.2011.73
   Rai D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2059
NR 3
TC 1
Z9 1
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PY 2013
VL 74
IS 9
BP 940
EP 941
DI 10.4088/JCP.13ac08607
PG 2
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 296LA
UT WOS:000330185300012
PM 24107768
ER

PT S
AU Becker, EBE
   Stoodley, CJ
AF Becker, Esther B. E.
   Stoodley, Catherine J.
BE Konopka, G
TI Autism Spectrum Disorder and the Cerebellum
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID TUBEROUS SCLEROSIS COMPLEX; FRAGILE-X-SYNDROME;
   LHERMITTE-DUCLOS-DISEASE; HIGH-FUNCTIONING AUTISM; FETAL-BRAIN PROTEINS;
   RETT-SYNDROME; PURKINJE-CELLS; ANGELMAN-SYNDROME; MOUSE MODELS; LANGUAGE
   DISORDER
AB The cerebellum has been long known for its importance in motor learning and coordination. Recently, anatomical, clinical, and neuroimaging studies strongly suggest that the cerebellum supports cognitive functions, including language and executive functions, as well as affective regulation. Furthermore, the cerebellum has emerged as one of the key brain regions affected in autism. Here, we discuss our current understanding of the role of the cerebellum in autism, including evidence from genetic, molecular, clinical, behavioral, and neuroimaging studies. Cerebellar findings in autism suggest developmental differences at multiple levels of neural structure and function, indicating that the cerebellum is an important player in the complex neural underpinnings of autism spectrum disorder, with behavioral implications beyond the motor domain.
C1 [Becker, Esther B. E.] Univ Oxford, Dept Physiol, MRC Funct Genom Unit, Oxford, England.
   [Stoodley, Catherine J.] Amer Univ, Dept Psychol, Washington, DC 20016 USA.
RP Becker, EBE (reprint author), Univ Oxford, Dept Physiol, MRC Funct Genom Unit, Oxford, England.
EM esther.becker@dpag.ox.ac.uk; stoodley@american.edu
CR Albrecht U, 1997, NAT GENET, V17, P75, DOI 10.1038/ng0997-75
   Aldinger KA, 2013, AM J MED GENET A, V161A, P131, DOI 10.1002/ajmg.a.35700
   Allen G, 2003, AM J PSYCHIAT, V160, P262, DOI 10.1176/appi.ajp.160.2.262
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   Backman SA, 2001, NAT GENET, V29, P396, DOI 10.1038/ng782
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   Ballif BA, 2004, CURR BIOL, V14, P606, DOI 10.1016/j.cub.2004.03.038
   Balsters JH, 2010, NEUROIMAGE, V49, P2045, DOI 10.1016/j.neuroimage.2009.10.045
   Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
   Baudouin SJ, 2012, SCIENCE, V338, P128, DOI 10.1126/science.1224159
   BAUMAN ML, 1995, NEUROLOGY, V45, P1581
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Belichenko NP, 2008, J COMP NEUROL, V508, P184, DOI 10.1002/cne.21673
   Belmonte MK, 2010, J CHILD PSYCHOL PSYC, V51, P259, DOI 10.1111/j.1469-7610.2009.02153.x
   Ben-Shachar S, 2009, HUM MOL GENET, V18, P2431, DOI 10.1093/hmg/ddp181
   Berg JM, 2012, GENOME BIOL, V13, DOI [10.1186/gb4034, 10.1186/gb-2012-13-7-247]
   Betancur C, 2009, TRENDS NEUROSCI, V32, P402, DOI 10.1016/j.tins.2009.04.003
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Bhat AN, 2012, INFANT BEHAV DEV, V35, P838, DOI 10.1016/j.infbeh.2012.07.019
   Bockers TM, 2001, J BIOL CHEM, V276, P40104, DOI 10.1074/jbc.M102454200
   Boer K, 2008, NEUROPATHOLOGY, V28, P577, DOI 10.1111/j.1440-1789.2008.00920.x
   Bolduc ME, 2009, DEV MED CHILD NEUROL, V51, P256, DOI 10.1111/j.1469-8749.2008.03224.x
   Bolduc ME, 2012, CEREBELLUM, V11, P531, DOI 10.1007/s12311-011-0312-z
   Bolduc ME, 2011, DEV MED CHILD NEUROL, V53, P409, DOI 10.1111/j.1469-8749.2011.03929.x
   Boukhtouche F, 2006, J NEUROSCI, V26, P1531, DOI 10.1523/JNEUROSCI.4636-05.2006
   Bozdagi O, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-15
   Braunschweig D, 2008, NEUROTOXICOLOGY, V29, P226, DOI 10.1016/j.neuro.2007.10.010
   Braunschweig D, 2012, ARCH NEUROL-CHICAGO, V69, P693, DOI 10.1001/archneurol.2011.2506
   Braunschweig D, 2012, J AUTISM DEV DISORD, V42, P1435, DOI 10.1007/s10803-011-1378-7
   Brielmaier J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040914
   Buckner RL, 2011, J NEUROPHYSIOL, V106, P2322, DOI 10.1152/jn.00339.2011
   Caria A, 2011, CEREB CORTEX, V21, P2838, DOI 10.1093/cercor/bhr084
   Catani M, 2008, NEUROIMAGE, V41, P1184, DOI 10.1016/j.neuroimage.2008.03.041
   Cauda F, 2011, J NEUROL NEUROSUR PS, V82, P1304, DOI 10.1136/jnnp.2010.239111
   Chang CH, 2010, RES DEV DISABIL, V31, P1536, DOI 10.1016/j.ridd.2010.06.003
   Cheh MA, 2006, BRAIN RES, V1116, P166, DOI 10.1016/j.brainres.2006.07.086
   Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906
   Cheron G, 2005, NEUROSCIENCE, V130, P631, DOI 10.1016/j.neuroscience.2004.09.013
   Cheung C, 2009, J CHILD PSYCHOL PSYC, V50, P1102, DOI 10.1111/j.1469-7610.2009.02086.x
   Cisternas FA, 2003, GENOMICS, V81, P279, DOI 10.1016/S0888-7543(02)00040-X
   Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005
   Cornish K, 2005, BRAIN COGNITION, V57, P53, DOI 10.1016/j.bandc.2004.08.020
   COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Courchesne E., 2012, AUTISM SPECTRUM DISO
   Critchley H, 2000, HUM BRAIN MAPP, V9, P93, DOI 10.1002/(SICI)1097-0193(200002)9:2<93::AID-HBM4>3.0.CO;2-Z
   Croen LA, 2008, BIOL PSYCHIAT, V64, P583, DOI 10.1016/j.biopsych.2008.05.006
   Dalton P, 2003, ANN NEUROL, V53, P533, DOI 10.1002/ana.10557
   DeLorey TM, 1998, J NEUROSCI, V18, P8505
   DeLorey TM, 2008, BEHAV BRAIN RES, V187, P207, DOI 10.1016/j.bbr.2007.09.009
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Di Martino A., 2013, MOL PSYCHIAT
   Diedrichsen J, 2009, NEUROIMAGE, V46, P39, DOI 10.1016/j.neuroimage.2009.01.045
   Diedrichsen J, 2006, NEUROIMAGE, V33, P127, DOI 10.1016/j.neuroimage.2006.05.056
   Dindot SV, 2008, HUM MOL GENET, V17, P111, DOI 10.1093/hmg/ddm288
   Duerden EG, 2012, AUTISM RES, V5, P49, DOI 10.1002/aur.235
   Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
   Ecker C, 2010, NEUROIMAGE, V49, P44, DOI 10.1016/j.neuroimage.2009.08.024
   Egawa K, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004655
   Ellegood J, 2010, NEUROIMAGE, V53, P1023, DOI 10.1016/j.neuroimage.2010.03.038
   Eluvathingal TJ, 2006, J CHILD NEUROL, V21, P846, DOI 10.2310/7010.2006.00192
   Eppig JT, 2012, NUCLEIC ACIDS RES, V40, pD881, DOI 10.1093/nar/gkr974
   Esposito G, 2011, BRAIN DEV-JPN, V33, P367, DOI 10.1016/j.braindev.2010.07.006
   Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9
   Fatemi SH, 2008, J AUTISM DEV DISORD, V39, P223
   Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P171, DOI 10.1023/A:1019861721160
   Fatemi SH, 2005, BIOL PSYCHIAT, V57, P777, DOI 10.1016/j.biopsych.2004.12.018
   Flanagan JE, 2012, AM J OCCUP THER, V66, P577, DOI 10.5014/ajot.2012.004192
   Fournier KA, 2010, GAIT POSTURE, V32, P6, DOI 10.1016/j.gaitpost.2010.02.007
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Freitag CM, 2007, J AUTISM DEV DISORD, V37, P948, DOI 10.1007/s10803-006-0235-6
   Frith U, 1991, AUTISM ASPERGER SYND
   Fujita E, 2008, P NATL ACAD SCI USA, V105, P3117, DOI 10.1073/pnas.0712298105
   Furge KA, 2000, ONCOGENE, V19, P5582, DOI 10.1038/sj.onc.1203859
   Gaffrey MS, 2007, NEUROPSYCHOLOGIA, V45, P1672, DOI 10.1016/j.neuropsychologia.2007.01.008
   Gepner B, 2002, TRENDS COGN SCI, V6, P455, DOI 10.1016/S1364-6613(02)02004-1
   Gernsbacher MA, 2008, J CHILD PSYCHOL PSYC, V49, P43, DOI 10.1111/j.1469-7610.2007.01820.x
   Gidley Larson J. C., 2006, AUTISM NEUROLOGICAL, P231
   Gilbert SJ, 2008, NEUROPSYCHOLOGIA, V46, P2281, DOI 10.1016/j.neuropsychologia.2008.03.025
   Goffin D, 2012, NAT NEUROSCI, V15, P274, DOI 10.1038/nn.2997
   Goines P, 2011, BRAIN BEHAV IMMUN, V25, P514, DOI 10.1016/j.bbi.2010.11.017
   Gold DA, 2007, BRAIN RES, V1140, P19, DOI 10.1016/j.brainres.2005.11.080
   Gomot M, 2006, NEUROIMAGE, V29, P475, DOI 10.1016/j.neuroimage.2005.07.027
   Gowen E, 2013, J AUTISM DEV DISORD, V43, P323, DOI 10.1007/s10803-012-1574-0
   Greco CM, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-2
   Green D, 2009, DEV MED CHILD NEUROL, V51, P311, DOI 10.1111/j.1469-8749.2008.03242.x
   Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054
   Greffou S, 2012, J AUTISM DEV DISORD, V42, P961, DOI 10.1007/s10803-011-1326-6
   Groen WB, 2010, CEREB CORTEX, V20, P1937, DOI 10.1093/cercor/bhp264
   Groszer M, 2008, CURR BIOL, V18, P354, DOI 10.1016/j.cub.2008.01.060
   Gutmann DH, 2000, ACTA NEUROPATHOL, V99, P223
   Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899
   Haist F, 2005, DEV NEUROPSYCHOL, V27, P425, DOI 10.1207/s15326942dn2703_7
   Hallahan B, 2009, PSYCHOL MED, V39, P337, DOI 10.1017/S0033291708003383
   HALLETT M, 1993, ARCH NEUROL-CHICAGO, V50, P1304
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Harris GJ, 2006, BRAIN COGNITION, V61, P54, DOI 10.1016/j.bandc.2005.12.015
   HEATH RG, 1977, J NERV MENT DIS, V165, P300
   Heck DH, 2008, HUM MOL GENET, V17, P2181, DOI 10.1093/hmg/ddn117
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   Herculano-Houzel S, 2010, FRONT NEUROANAT, V4, DOI 10.3389/fnana.2010.00012
   Hesling I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011571
   Heuer L, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.48
   Hilton CL, 2012, AUTISM, V16, P430, DOI 10.1177/1362361311423018
   Hodge SM, 2010, J AUTISM DEV DISORD, V40, P300, DOI 10.1007/s10803-009-0872-7
   HONDA S, 1995, MOL BRAIN RES, V32, P197, DOI 10.1016/0169-328X(95)00075-4
   Hong SE, 2000, NAT GENET, V26, P93
   Ieraci A, 2002, P NATL ACAD SCI USA, V99, P15200, DOI 10.1073/pnas.222362099
   Ingram JL, 2000, NEUROTOXICOL TERATOL, V22, P319, DOI 10.1016/S0892-0362(99)00083-5
   Jeste SS, 2011, CURR OPIN NEUROL, V24, P132, DOI 10.1097/WCO.0b013e3283446450
   Jiang YH, 2013, NEURON, V78, P8, DOI 10.1016/j.neuron.2013.03.016
   Jiang YH, 1998, NEURON, V21, P799, DOI 10.1016/S0896-6273(00)80596-6
   JONES V, 1985, J AUTISM DEV DISORD, V15, P37, DOI 10.1007/BF01837897
   Jordan C, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-36
   Kaufmann WE, 2003, J CHILD NEUROL, V18, P463, DOI 10.1177/08830738030180070501
   Kemper TL, 1998, J NEUROPATH EXP NEUR, V57, P645, DOI 10.1097/00005072-199807000-00001
   Kleinhans NM, 2007, BRAIN RES, V1162, P85, DOI 10.1016/j.brainres.2007.04.081
   Knaus TA, 2008, J INT NEUROPSYCH SOC, V14, P967, DOI 10.1017/S1355617708081216
   Koekkoek SKE, 2005, NEURON, V47, P339, DOI 10.1016/j.neuron.2005.07.005
   Kuemerle B, 1997, J NEUROSCI, V17, P7881
   Kwon CH, 2001, NAT GENET, V29, P404, DOI 10.1038/ng781
   Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
   LAURIE DJ, 1992, J NEUROSCI, V12, P4151
   Limperopoulos C, 2010, PEDIATR RES, V68, P145, DOI 10.1203/00006450-201011001-00282
   Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
   Limperopoulos C, 2007, PEDIATRICS, V120, P584, DOI 10.1542/peds.2007-1041
   Linkenauger SA, 2012, AUTISM RES, V5, P352, DOI 10.1002/aur.1248
   MacNeil LK, 2012, NEUROPSYCHOLOGY, V26, P165, DOI 10.1037/a0026955
   MARIANI J, 1977, PHILOS T ROY SOC B, V281, P1, DOI 10.1098/rstb.1977.0121
   Marino S, 2002, DEVELOPMENT, V129, P3513
   MILLEN KJ, 1994, DEVELOPMENT, V120, P695
   Minshew NJ, 2004, NEUROLOGY, V63, P2056
   Miura K, 2002, NEUROBIOL DIS, V9, P149, DOI 10.1006/nbdi.2001.0463
   Molloy CA, 2003, J AUTISM DEV DISORD, V33, P643, DOI 10.1023/B:JADD.0000006001.00667.4c
   Moran Matthew F, 2013, Front Integr Neurosci, V7, P14, DOI 10.3389/fnint.2013.00014
   Mosconi MW, 2010, ARCH GEN PSYCHIAT, V67, P830, DOI 10.1001/archgenpsychiatry.2010.87
   Mosconi MW, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063709
   Mostofsky SH, 1998, NEUROLOGY, V50, P121
   Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
   Mostofsky SH, 2000, J INT NEUROPSYCH SOC, V6, P752, DOI 10.1017/S1355617700677020
   Mullaney BC, 2004, NEUROSCIENCE, V123, P939, DOI 10.1016/j.neuroscience.2003.11.025
   Muller RA, 2003, AM J PSYCHIAT, V160, P1847, DOI 10.1176/appi.ajp.160.10.1847
   MURAKAMI JW, 1989, ARCH NEUROL-CHICAGO, V46, P689
   MURAKAMI JW, 1992, AM J ROENTGENOL, V159, P177
   Mychasiuk R, 2012, DEV NEUROSCI-BASEL, V34, P268, DOI 10.1159/000341786
   Nickl-Jockschat T, 2012, HUM BRAIN MAPP, V33, P1470, DOI 10.1002/hbm.21299
   Noterdaeme M, 2002, EUR CHILD ADOLES PSY, V11, P219, DOI 10.1007/s00787-002-0285-z
   OLDFORS A, 1990, PEDIATR NEUROL, V6, P310, DOI 10.1016/0887-8994(90)90022-S
   Ozonoff S, 1999, J CHILD NEUROL, V14, P636, DOI 10.1177/088307389901401003
   Paakki JJ, 2010, BRAIN RES, V1321, P169, DOI 10.1016/j.brainres.2009.12.081
   Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
   Papadopoulos N, 2012, AUTISM, V16, P627, DOI 10.1177/1362361311418692
   Park TJ, 2008, J NEUROSCI, V28, P13551, DOI 10.1523/JNEUROSCI.4323-08.2008
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Peca J, 2012, CURR OPIN NEUROBIOL, V22, P866, DOI 10.1016/j.conb.2012.02.015
   Pierce K, 2001, BIOL PSYCHIAT, V49, P655, DOI 10.1016/S0006-3223(00)01008-8
   Pitskel NB, 2011, J AUTISM DEV DISORD, V41, P1686, DOI 10.1007/s10803-011-1197-x
   Radonovich K J, 2013, Front Integr Neurosci, V7, P28, DOI 10.3389/fnint.2013.00028
   Radyushkin K, 2009, GENES BRAIN BEHAV, V8, P416, DOI 10.1111/j.1601-183X.2009.00487.x
   Reith RM, 2013, NEUROBIOL DIS, V51, P93, DOI 10.1016/j.nbd.2012.10.014
   Reith RM, 2011, NEUROBIOL DIS, V43, P113, DOI 10.1016/j.nbd.2011.02.014
   Reynolds S, 2012, DEV NEUROSCI-BASEL, V34, P258, DOI 10.1159/000336646
   Rice DS, 2001, ANNU REV NEUROSCI, V24, P1005, DOI 10.1146/annurev.neuro.24.1.1005
   Rinehart NJ, 2006, J AUTISM DEV DISORD, V36, P757, DOI 10.1007/s10803-006-0118-x
   Rinehart NJ, 2006, DEV MED CHILD NEUROL, V48, P819, DOI 10.1017/S0012162206001769
   Riva D, 2013, CEREBELLUM, V12, P676, DOI 10.1007/s12311-013-0469-8
   Riva D, 2000, BRAIN, V123, P1051, DOI 10.1093/brain/123.5.1051
   Rodier P, 1996, MENTAL RETARD DEV DI, V2, P249, DOI 10.1002/(SICI)1098-2779(1996)2:4<249::AID-MRDD9>3.0.CO;2-L
   Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162
   Rogers Tiffany D, 2013, Front Syst Neurosci, V7, P15, DOI 10.3389/fnsys.2013.00015
   Rogers TD, 2013, CEREBELLUM, V12, P547, DOI 10.1007/s12311-013-0462-2
   Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
   Roullet FI, 2010, NEUROSCIENCE, V170, P514, DOI 10.1016/j.neuroscience.2010.06.069
   Roy S, 2011, BEHAV NEUROSCI, V125, P962, DOI 10.1037/a0025920
   Sabaratnam M, 2000, J INTELL DISABIL RES, V44, P81, DOI 10.1046/j.1365-2788.2000.00261.x
   Sadakata T, 2004, J NEUROSCI, V24, P43, DOI 10.1523/JNEUROSCI.2528-03.2004
   Sadakata T, 2007, J CLIN INVEST, V117, P931, DOI 10.1172/JCI29031
   Sadakata T, 2007, J NEUROSCI, V27, P2472, DOI 10.1523/JNEUROSCI.2279-06.2007
   Schmahmann JD, 1998, BRAIN, V121, P561, DOI 10.1093/brain/121.4.561
   Schmahmann JD, 2007, CEREBELLUM, V6, P254, DOI 10.1080/14734220701490995
   Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
   Schulte-Ruther M, 2011, SOC NEUROSCI-UK, V6, P1, DOI 10.1080/17470911003708032
   SEARS LL, 1994, J AUTISM DEV DISORD, V24, P737, DOI 10.1007/BF02172283
   Shafritz KM, 2008, BIOL PSYCHIAT, V63, P974, DOI 10.1016/j.biopsych.2007.06.028
   Shu WG, 2005, P NATL ACAD SCI USA, V102, P9643, DOI 10.1073/pnas.0503739102
   SIDMAN RL, 1962, SCIENCE, V137, P610, DOI 10.1126/science.137.3530.610
   Silani G, 2008, SOC NEUROSCI, V3, P97, DOI 10.1080/17470910701577020
   Singer HS, 2008, J NEUROIMMUNOL, V194, P165, DOI 10.1016/j.jneuroim.2007.11.004
   Sivaswamy L, 2010, J CHILD NEUROL, V25, P1223, DOI 10.1177/0883073809358765
   Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019
   Speidel D, 2003, J BIOL CHEM, V278, P52802, DOI 10.1074/jbc.M304727200
   Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006
   Steinmetz JE, 2001, INTEGR PHYS BEH SCI, V36, P220, DOI 10.1007/BF02734095
   Stieglitz Ham Heidi, 2011, J Autism Dev Disord, V41, P1, DOI 10.1007/s10803-010-1011-1
   Stooclley C. J., 2012, SOC NEUR ANN M NEW O
   Stoodley CJ, 2012, CEREBELLUM, V11, P352, DOI 10.1007/s12311-011-0260-7
   Stoodley CJ, 2009, NEUROIMAGE, V44, P489, DOI 10.1016/j.neuroimage.2008.08.039
   Stoodley CJ, 2010, CORTEX, V46, P831, DOI 10.1016/j.cortex.2009.11.008
   Sweet HO, 1996, MAMM GENOME, V7, P798, DOI 10.1007/s003359900240
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Takarae Y, 2007, PSYCHIAT RES-NEUROIM, V156, P117, DOI 10.1016/j.pseychresns.2007.03.008
   Takarae Y, 2004, BRAIN, V127, P2584, DOI 10.1093/brain/awh307
   Takarae Y, 2004, J NEUROL NEUROSUR PS, V75, P1359, DOI 10.1136/jnnp.2003.022491
   Tavano A, 2007, BRAIN, V130, P2646, DOI 10.1093/brain/awm201
   Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
   Tesink CMJY, 2011, NEUROPSYCHOLOGIA, V49, P1095, DOI 10.1016/j.neuropsychologia.2011.01.018
   Tobia MJ, 2009, BEHAV NEUROSCI, V123, P665, DOI 10.1037/a0015662
   Travers BG, 2012, AUTISM RES, V5, P289, DOI 10.1002/aur.1243
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   Vaughn J, 2013, AM J NEURORADIOL, V34, P655, DOI 10.3174/ajnr.A3260
   Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
   Vollm BA, 2006, NEUROIMAGE, V29, P90, DOI 10.1016/j.neuroimage.2005.07.022
   Wagner GC, 2006, J AUTISM DEV DISORD, V36, P779, DOI 10.1007/s10803-006-0117-y
   Wang AT, 2007, ARCH GEN PSYCHIAT, V64, P698, DOI 10.1001/archpsyc.64.6.698
   Webb SJ, 2009, PSYCHIAT RES-NEUROIM, V172, P61, DOI 10.1016/j.pscychresns.2008.06.001
   Weber AM, 2000, J AUTISM DEV DISORD, V30, P511, DOI 10.1023/A:1005679108529
   WEGIEL J, 2010, NEUROPSYCHOL REV, V119, P755, DOI DOI 10.1007/S00401-010-0655-4
   Weisenfeld NI, 2013, PEDIATR NEUROL, V48, P105, DOI 10.1016/j.pediatrneurol.2012.10.011
   Whitney ER, 2009, J NEUROSCI RES, V87, P2245, DOI 10.1002/jnr.22056
   Whitney ER, 2008, CEREBELLUM, V7, P406, DOI 10.1007/s12311-008-0043-y
   Whyatt CP, 2012, J AUTISM DEV DISORD, V42, P1799, DOI 10.1007/s10803-011-1421-8
   Wills S, 2009, BRAIN BEHAV IMMUN, V23, P64, DOI 10.1016/j.bbi.2008.07.007
   Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
   Yang M., 2011, J NEUROSCI, V32, P6525
   Yochum CL, 2008, BRAIN RES, V1203, P126, DOI 10.1016/j.brainres.2008.01.055
   Yu KK, 2011, J PSYCHIATR NEUROSCI, V36, P412, DOI 10.1503/jpn.100138
   Ziats MN, 2013, CEREBELLUM, V12, P776, DOI 10.1007/s12311-013-0483-x
   Zimmerman AW, 2007, BRAIN BEHAV IMMUN, V21, P351, DOI 10.1016/j.bbi.2006.08.005
   Zwaigenbaum L, 2013, BEHAV BRAIN RES, V251, P133, DOI 10.1016/j.bbr.2013.04.004
NR 231
TC 5
Z9 5
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 1
EP 34
DI 10.1016/B978-0-12-418700-9.00001-0
PG 34
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100002
PM 24290381
ER

PT S
AU Konopka, G
AF Konopka, Genevieve
BE Konopka, G
TI The Neurobiology of Autism: Integrating Genetics, Brain Development,
   Behavior, and the Environment PREFACE
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Editorial Material; Book Chapter
C1 UT Southwestern Med Ctr, Dept Neurosci, Dallas, TX 75390 USA.
RP Konopka, G (reprint author), UT Southwestern Med Ctr, Dept Neurosci, Dallas, TX 75390 USA.
NR 0
TC 1
Z9 1
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP XI
EP XII
PG 2
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100001
PM 24290391
ER

PT S
AU Wilkinson, B
   Campbell, DB
AF Wilkinson, Brent
   Campbell, Daniel B.
BE Konopka, G
TI Contribution of Long Noncoding RNAs to Autism Spectrum Disorder Risk
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID X-CHROMOSOME INACTIVATION; SMALL INTERFERING RNAS; GENE-EXPRESSION;
   CELL-PROLIFERATION; ENDOGENOUS SIRNAS; PROSTATE-CANCER; MESSENGER-RNAS;
   BC200 RNA; NEURODEVELOPMENTAL DISORDERS; HEPATOCELLULAR-CARCINOMA
AB Accumulating evidence indicates that long noncoding RNAs (IncRNAs) contribute to autism spectrum disorder (ASD) risk. Although a few IncRNAs have long been recognized to have important functions, the vast majority of this class of molecules remains uncharacterized. Because IncRNAs are more abundant in human brain than protein-coding RNAs, it is likely that they contribute to brain disorders, including ASD. We review here the known functions of IncRNAs and the potential contributions of IncRNAs to ASD.
C1 [Wilkinson, Brent] Univ So Calif, Program Biol & Biomed Sci, Los Angeles, CA 90089 USA.
   [Wilkinson, Brent; Campbell, Daniel B.] Univ So Calif, Zilkha Neurogenet Inst, Los Angeles, CA USA.
   [Campbell, Daniel B.] Univ So Calif, Dept Psychiat & Behav Sci, Los Angeles, CA USA.
RP Campbell, DB (reprint author), Univ So Calif, Program Biol & Biomed Sci, Los Angeles, CA 90089 USA.
EM dbcampbe@med.usc.edu
CR Altuvia Y, 2005, NUCLEIC ACIDS RES, V33, P2697, DOI 10.1093/nar/gki567
   Alvarez-Garcia I, 2005, DEVELOPMENT, V132, P4653, DOI 10.1242/dev.02073
   Amaral PP, 2009, RNA, V15, P2013, DOI 10.1261/rna.1705309
   Amiri A, 2012, J NEUROSCI, V32, P5880, DOI 10.1523/JNEUROSCI.5462-11.2012
   Anderson SA, 1997, SCIENCE, V278, P474, DOI 10.1126/science.278.5337.474
   Ashley-Koch AE, 2007, PSYCHIAT GENET, V17, P221, DOI 10.1097/YPG.0b013e32809c2f75
   Atwal J. K., 2011, SCI TRANSL MED, V3, P1, DOI DOI 10.1126/SCITRANSLMED.3002254
   Babiarz JE, 2008, GENE DEV, V22, P2773, DOI 10.1101/gad.1705308
   Barry G., 2013, MOL PSYCHIAT
   Berezikov E, 2005, CELL, V120, P21, DOI 10.1016/j.cell.2004.12.031
   Bernard D, 2010, EMBO J, V29, P3082, DOI 10.1038/emboj.2010.199
   Bertone P, 2004, SCIENCE, V306, P2242, DOI 10.1126/science.1103388
   Birney E, 2007, NATURE, V447, P799, DOI 10.1038/nature05874
   Bond AM, 2009, NAT NEUROSCI, V12, P1020, DOI 10.1038/nn.2371
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   BROWN CJ, 1992, CELL, V71, P527, DOI 10.1016/0092-8674(92)90520-M
   BROWN SDM, 1991, BIOESSAYS, V13, P607, DOI 10.1002/bies.950131112
   Burnett JC, 2012, CHEM BIOL, V19, P60, DOI 10.1016/j.chembiol.2011.12.008
   Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646
   Cai HB, 2001, NAT NEUROSCI, V4, P233, DOI 10.1038/85064
   Cairns P, 1997, CANCER RES, V57, P4997
   Carninci P, 2006, NAT GENET, V38, P626, DOI 10.1038/ng1789
   Carthew RW, 2009, CELL, V136, P642, DOI 10.1016/j.cell.2009.01.035
   Chan AS, 2002, ONCOGENE, V21, P3029, DOI 10.1038/sj/onc/1205460
   Chan WL, 2013, NUCLEIC ACIDS RES, V41, P3734, DOI 10.1093/nar/gkt047
   Cheng J, 2005, SCIENCE, V308, P1149, DOI 10.1126/science.1108625
   Chodroff RA, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-7-r72
   Chung WJ, 2008, CURR BIOL, V18, P795, DOI 10.1016/j.cub.2008.05.006
   Core LJ, 2008, SCIENCE, V322, P1845, DOI 10.1126/science.1162228
   de la Grange P, 2010, NUCLEIC ACIDS RES, V38, P2825, DOI 10.1093/nar/gkq008
   Djebali S, 2012, NATURE, V489, P101, DOI 10.1038/nature11233
   Eastwood SL, 2006, AM J PSYCHIAT, V163, P540, DOI 10.1176/appi.ajp.163.3.540
   Egan MF, 2003, CELL, V112, P257, DOI 10.1016/S0092-8674(03)00035-7
   Elbashir SM, 2001, EMBO J, V20, P6877, DOI 10.1093/emboj/20.23.6877
   Ellis P, 2004, DEV NEUROSCI-BASEL, V26, P148, DOI 10.1159/000082134
   Faghihi MA, 2008, NAT MED, V14, P723, DOI 10.1038/nm1784
   Fantes J, 2003, NAT GENET, V33, P461, DOI 10.1038/ng1120
   Fatemi SH, 2011, ANAT REC, V294, P1635, DOI 10.1002/ar.21299
   Favaro R, 2009, NAT NEUROSCI, V12, P1248, DOI 10.1038/nn.2397
   Feng JC, 2006, GENE DEV, V20, P1470, DOI 10.1101/gad.1416106
   Ferri ALM, 2004, DEVELOPMENT, V131, P3805, DOI 10.1242/dev.01204
   Friedman RC, 2009, GENOME RES, V19, P92, DOI 10.1101/gr.082701.108
   Gadow KD, 2009, J AUTISM DEV DISORD, V39, P1542, DOI 10.1007/s10803-009-0794-4
   Garber KB, 2008, EUR J HUM GENET, V16, P666, DOI 10.1038/ejhg.2008.61
   Grant SGN, 2012, CURR OPIN NEUROBIOL, V22, P522, DOI 10.1016/j.conb.2012.02.002
   Grosso AR, 2008, NUCLEIC ACIDS RES, V36, P4823, DOI 10.1093/nar/gkn463
   Guidi S, 2008, BRAIN PATHOL, V18, P180, DOI 10.1111/j.1750-3639.2007.00113.x
   Guo HL, 2010, NATURE, V466, P835, DOI 10.1038/nature09267
   Gupta RA, 2010, NATURE, V464, P1071, DOI 10.1038/nature08975
   Hock C, 2000, ARCH NEUROL-CHICAGO, V57, P846, DOI 10.1001/archneur.57.6.846
   Hogart A, 2007, HUM MOL GENET, V16, P691, DOI 10.1093/hmg/ddm014
   Horch HW, 2002, NAT NEUROSCI, V5, P1177, DOI 10.1038/nn927
   Horder J, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.53
   Horsthemke B, 2008, AM J MED GENET A, V146A, P2041, DOI 10.1002/ajmg.a.32364
   Howells DW, 2000, EXP NEUROL, V166, P127, DOI 10.1006/exnr.2000.7483
   Hsieh J, 2010, NEUROBIOL DIS, V39, P73, DOI 10.1016/j.nbd.2010.01.008
   Hu V.W., 2013, FUTURE NEUROL, V8, P29, DOI [10.2217/fnl.12.83, DOI 10.2217/FNL.12.83]
   Hu VW, 2009, AUTISM RES, V2, P78, DOI 10.1002/aur.73
   Huttenlocher PR, 1997, J COMP NEUROL, V387, P167, DOI 10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z
   Hutvagner G, 2002, SCIENCE, V297, P2056, DOI 10.1126/science.1073827
   Ibanez-Ventoso C, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002818
   Impagnatiello F, 1998, P NATL ACAD SCI USA, V95, P15718, DOI 10.1073/pnas.95.26.15718
   Investigators Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal & Prevention Centers for Disease Control, 2012, MMWR SURVEILL SUMM, V61, P1
   Ishibashi M, 2013, ONCOL REP, V29, P946, DOI 10.3892/or.2012.2219
   Jalali S, 2012, BIOL DIRECT, V7, DOI 10.1186/1745-6150-7-25
   Ji P, 2003, ONCOGENE, V22, P8031, DOI 10.1038/sj.onc.1206928
   Jiang J, 2013, NATURE, V500, P296, DOI 10.1038/nature12394
   Johnsson P, 2013, NAT STRUCT MOL BIOL, V20, P440, DOI 10.1038/nsmb.2516
   Kapranov P, 2007, SCIENCE, V316, P1484, DOI 10.1126/science.1138341
   Katoh-Semba R, 2007, INT J DEV NEUROSCI, V25, P367, DOI 10.1016/j.ijdevneu.2007.07.002
   Keniry A, 2012, NAT CELL BIOL, V14, P659, DOI 10.1038/ncb2521
   Kerin T., 2012, SCI TRANSL MED, V4, DOI DOI 10.1126/SCITRANSLMED.300347
   Khalil AM, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001486
   Kim VN, 2009, NAT REV MOL CELL BIO, V10, P126, DOI 10.1038/nrm2632
   Kishino T, 1997, NAT GENET, V15, P70, DOI 10.1038/ng0197-70
   Kogo R, 2011, CANCER RES, V71, P6320, DOI 10.1158/0008-5472.CAN-11-1021
   Krebs MO, 2000, MOL PSYCHIATR, V5, P558, DOI 10.1038/sj.mp.4000749
   Krek A, 2005, NAT GENET, V37, P495, DOI 10.1038/ng1536
   Kuwajima T, 2006, J NEUROSCI, V26, P5383, DOI 10.1523/JNEUROSCI.1262-06.2006
   Ladd PD, 2007, HUM MOL GENET, V16, P3174, DOI 10.1093/hmg/ddm293
   Lai EC, 2002, NAT GENET, V30, P363, DOI 10.1038/ng865
   Lander ES, 2001, NATURE, V409, P860, DOI 10.1038/35057062
   Law AJ, 2007, HUM MOL GENET, V16, P129, DOI 10.1093/hmg/ddl449
   LEE RC, 1993, CELL, V75, P843, DOI 10.1016/0092-8674(93)90529-Y
   Lewis DA, 2005, NAT REV NEUROSCI, V6, P312, DOI 10.1038/nrn1648
   Li HW, 2002, SCIENCE, V296, P1319, DOI 10.1126/science.1070948
   Li J, 1997, SCIENCE, V275, P1943, DOI 10.1126/science.275.5308.1943
   Lin MY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023356
   Lipovich L., 2013, CEREBRAL CORTEX
   Lipovich L, 2012, GENETICS, V192, P1133, DOI 10.1534/genetics.112.145128
   Liu QR, 2006, BRAIN RES, V1067, P1, DOI 10.1016/j.brainres.2005.10.004
   Loesch DZ, 2011, GENET MED, V13, P392, DOI 10.1097/GIM.0b013e3182064362
   Luteijn MJ, 2013, NAT REV GENET, V14, P523, DOI 10.1038/nrg3495
   Lytle JR, 2007, P NATL ACAD SCI USA, V104, P9667, DOI 10.1073/pnas.0703820104
   MARTIGNETTI JA, 1993, P NATL ACAD SCI USA, V90, P11563, DOI 10.1073/pnas.90.24.11563
   Martinez J, 2002, CELL, V110, P563, DOI 10.1016/S0092-8674(02)00908-X
   Matera AG, 2007, NAT REV MOL CELL BIO, V8, P209, DOI 10.1038/nrm2124
   Mattick JS, 2005, HUM MOL GENET, V14, pR121, DOI 10.1093/hmg/ddi101
   Meng LY, 2012, HUM MOL GENET, V21, P3001, DOI 10.1093/hmg/dds130
   Mercer TR, 2008, P NATL ACAD SCI USA, V105, P716, DOI 10.1073/pnas.0706729105
   Mercer TR, 2009, NAT REV GENET, V10, P155, DOI 10.1038/nrg2521
   Millar JK, 2000, HUM MOL GENET, V9, P1415, DOI 10.1093/hmg/9.9.1415
   Ming GL, 2005, ANNU REV NEUROSCI, V28, P223, DOI 10.1146/annurev.neuro.28.051804.101459
   Morikawa T, 2010, NEUROCHEM INT, V57, P691, DOI 10.1016/j.neuint.2010.08.012
   Moseley ML, 2006, NAT GENET, V38, P758, DOI 10.1038/ng1827
   Muddashetty RS, 2002, J MOL BIOL, V321, P433, DOI 10.1016/S0022-2836(02)00655-1
   Mus E, 2007, P NATL ACAD SCI USA, V104, P10679, DOI 10.1073/pnas.0701532104
   Nagano T, 2008, SCIENCE, V322, P1717, DOI 10.1126/science.1163802
   Nagano T, 2011, CELL, V145, P178, DOI 10.1016/j.cell.2011.03.014
   Nakata K, 2009, P NATL ACAD SCI USA, V106, P15873, DOI 10.1073/pnas.0903413106
   Neves-Pereira M, 2005, MOL PSYCHIATR, V10, P208, DOI 10.1038/sj.mp.4001575
   Ng SY, 2012, EMBO J, V31, P522, DOI 10.1038/emboj.2011.459
   Nicholls RD, 2001, ANNU REV GENOM HUM G, V2, P153, DOI 10.1146/annurev.genom.2.1.153
   Nieto R, 2013, Front Psychiatry, V4, P45, DOI 10.3389/fpsyt.2013.00045
   O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
   Pang KC, 2006, TRENDS GENET, V22, P1, DOI 10.1016/j.tig.2005.10.003
   Pearson JC, 2005, NAT REV GENET, V6, P893, DOI 10.1038/nrg1726
   Penny GD, 1996, NATURE, V379, P131, DOI 10.1038/379131a0
   Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850
   Petanjek Z, 2011, P NATL ACAD SCI USA, V108, P13281, DOI 10.1073/pnas.1105108108
   Plath K, 2003, SCIENCE, V300, P131, DOI 10.1126/science.1084274
   Poliseno L, 2010, NATURE, V465, P1033, DOI 10.1038/nature09144
   Pollard KS, 2006, NATURE, V443, P167, DOI 10.1038/nature05113
   Ponjavic J, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000617
   Ponting CP, 2009, CELL, V136, P629, DOI 10.1016/j.cell.2009.02.006
   Pruunsild P, 2007, GENOMICS, V90, P397, DOI 10.1016/j.ygeno.2007.05.004
   Qin R, 2013, NEOPLASMA, V60, P486, DOI 10.4149/neo_2013_063
   Reif A, 2006, MOL PSYCHIATR, V11, P514, DOI 10.1038/sj.mp.4001791
   Ricci S, 2013, NEUROTOX RES, V24, P491, DOI 10.1007/s12640-013-9393-4
   Rinn JL, 2007, CELL, V129, P1311, DOI 10.1016/j.cell.2007.05.022
   Rinn JL, 2012, ANNU REV BIOCHEM, V81, P145, DOI 10.1146/annurev-biochem-051410-092902
   Ross-Inta C, 2010, BIOCHEM J, V429, P545, DOI 10.1042/BJ20091960
   Rougeulle C, 1998, NAT GENET, V19, P15, DOI 10.1038/ng0598-15
   Samaco RC, 2005, HUM MOL GENET, V14, P483, DOI 10.1093/hmg/ddi045
   Sayed D, 2011, PHYSIOL REV, V91, P827, DOI 10.1152/physrev.00006.2010
   Seila AC, 2008, SCIENCE, V322, P1849, DOI 10.1126/science.1162253
   Singer O, 2005, NAT NEUROSCI, V8, P1343, DOI 10.1038/nn1531
   Sleutels F, 2002, NATURE, V415, P810
   Song R, 2011, P NATL ACAD SCI USA, V108, P13159, DOI 10.1073/pnas.1108567108
   St Pourcain Beate, 2010, Am J Psychiatry, V167, P1364, DOI 10.1176/appi.ajp.2010.09121789
   Sullivan PF, 2003, ARCH GEN PSYCHIAT, V60, P1187, DOI 10.1001/archpsyc.60.12.1187
   Taft RJ, 2007, BIOESSAYS, V29, P288, DOI 10.1002/bies.20544
   Tam OH, 2008, NATURE, V453, P534, DOI 10.1038/nature06904
   Tanaka JI, 2008, SCIENCE, V319, P1683, DOI 10.1126/science.1152864
   Taylor MS, 2003, GENOMICS, V81, P67, DOI 10.1016/S0888-7543(02)00026-5
   Carninci P, 2005, SCIENCE, V309, P1559, DOI 10.1126/science.1112014
   TIEDGE H, 1993, J NEUROSCI, V13, P2382
   Tripathi V, 2010, MOL CELL, V39, P925, DOI 10.1016/j.molcel.2010.08.011
   Uhde CW, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008641
   Vallot C, 2013, NAT GENET, V45, P239, DOI 10.1038/ng.2530
   Vlietstra RJ, 1998, CANCER RES, V58, P2720
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Wang KC, 2011, MOL CELL, V43, P904, DOI 10.1016/j.molcel.2011.08.018
   Wang PJ, 2012, J CELL BIOCHEM, V113, P1868, DOI 10.1002/jcb.24055
   Wang XH, 2006, SCIENCE, V312, P452, DOI 10.1126/science.1125694
   Watanabe T, 2008, NATURE, V453, P539, DOI 10.1038/nature06908
   Watson P, 2001, J MED GENET, V38, P224, DOI 10.1136/jmg.38.4.224
   Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
   Wheeler E, 2013, NAT GENET, V45, P513, DOI 10.1038/ng.2607
   Wienholds E, 2005, FEBS LETT, V579, P5911, DOI 10.1016/j.febslet.2005.07.070
   Winter J, 2009, NAT CELL BIOL, V11, P228, DOI 10.1038/ncb0309-228
   Wonders CP, 2006, NAT REV NEUROSCI, V7, P687, DOI 10.1038/nrn1954
   Xia J, 2013, HUM MOL GENET, V22, P737, DOI 10.1093/hmg/dds481
   Yamasaki K., 2003, Human Molecular Genetics, V12, P837, DOI 10.1093/hmg/ddg106
   Yang N, 2006, NAT STRUCT MOL BIOL, V13, P763, DOI 10.1038/nsmb1141
   Ying L, 2013, MOL BIOSYST, V9, P407, DOI 10.1039/c2mb25386k
   Yotova IY, 2008, GENOMICS, V92, P464, DOI 10.1016/j.ygeno.2008.08.004
   Zhang X, 2003, J CLIN ENDOCR METAB, V88, P5119, DOI 10.1210/jc.2003-030222
   Zhang X, 2010, CANCER RES, V70, P2350, DOI 10.1158/0008-5472.CAN-09-3885
   Zhao J, 2005, J CLIN ENDOCR METAB, V90, P2179, DOI 10.1210/jc.2004-1848
   Ziats MN, 2013, J MOL NEUROSCI, V49, P589, DOI 10.1007/s12031-012-9880-8
   Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
NR 173
TC 2
Z9 3
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 35
EP 59
DI 10.1016/B978-0-12-418700-9.00002-2
PG 25
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100003
PM 24290382
ER

PT S
AU Maloney, SE
   Rieger, MA
   Dougherty, JD
AF Maloney, Susan E.
   Rieger, Michael A.
   Dougherty, Joseph D.
BE Konopka, G
TI Identifying Essential Cell Types and Circuits in Autism Spectrum
   Disorders
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID DE-NOVO MUTATIONS; OBSESSIVE-COMPULSIVE DISORDER; TRANSLATIONAL
   PROFILING APPROACH; COMMON GENETIC-VARIANTS; RETT-SYNDROME; KNOCKOUT
   MICE; MOUSE MODEL; REPETITIVE BEHAVIOR; MUTANT MICE; SEROTONIN
   TRANSPORTER
AB Autism spectrum disorder (ASD) is highly genetic in its etiology, with potentially hundreds of genes contributing to risk. Despite this heterogeneity, these disparate genetic lesions may result in the disruption of a limited number of key cell types or circuits-information which could be leveraged for the design of therapeutic interventions. While hypotheses for cellular disruptions can be identified by postmortem anatomical analysis and expression studies of ASD risk genes, testing these hypotheses requires the use of animal models. In this review, we explore the existing evidence supporting the contribution of different cell types to ASD, specifically focusing on rodent studies disrupting serotonergic, GABAergic, cerebellar, and striatal cell types, with particular attention to studies of the sufficiency of specific cellular disruptions to generate ASD-related behavioral abnormalities. This evidence suggests multiple cellular routes can create features of the disorder, though it is currently unclear if these cell types converge on a final common circuit. We hope that in the future, systematic studies of cellular sufficiency and genetic interaction will help to classify patients into groups by type of cellular disruptions which suggest tractable therapeutic targets.
C1 [Maloney, Susan E.; Rieger, Michael A.; Dougherty, Joseph D.] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63130 USA.
   [Maloney, Susan E.; Rieger, Michael A.; Dougherty, Joseph D.] Washington Univ, Dept Psychiat, Sch Med, St Louis, MO USA.
RP Dougherty, JD (reprint author), Washington Univ, Sch Med, Dept Genet, St Louis, MO 63130 USA.
EM jdougherty@genetics.wustl.edu
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Adachi M, 2009, J NEUROSCI, V29, P4218, DOI 10.1523/JNEUROSCI.4225-08.2009
   Alenina N, 2009, P NATL ACAD SCI USA, V106, P10332, DOI 10.1073/pnas.0810793106
   Allen G, 2004, BIOL PSYCHIAT, V56, P269, DOI 10.1016/j.biophsych.2004.06.005
   Alvarez-Saavedra M, 2007, HUM MOL GENET, V16, P2315, DOI 10.1093/hmg/ddm185
   Amiri A, 2012, J NEUROSCI, V32, P5880, DOI 10.1523/JNEUROSCI.5462-11.2012
   ANDERSON GM, 1987, J CHILD PSYCHOL PSYC, V28, P885, DOI 10.1111/j.1469-7610.1987.tb00677.x
   Angoa-Perez M, 2012, J NEUROCHEM, V121, P974, DOI 10.1111/j.1471-4159.2012.07739.x
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Arakawa H, 2008, NEUROSCI BIOBEHAV R, V32, P1236, DOI 10.1016/j.neubiorev.2008.05.012
   Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
   Azmitia EC, 2011, NEUROPHARMACOLOGY, V60, P1347, DOI 10.1016/j.neuropharm.2011.02.002
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
   Ballas N, 2009, NAT NEUROSCI, V12, P311, DOI 10.1038/nn.2275
   Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
   Beaulieu JM, 2008, P NATL ACAD SCI USA, V105, P1333, DOI 10.1073/pnas.0711496105
   Berg JM, 2012, GENOME BIOL, V13, DOI [10.1186/gb4034, 10.1186/gb-2012-13-7-247]
   Betancur C, 2002, MOL PSYCHIATR, V7, P67, DOI 10.1038/sj/mp/4000923
   Bozdagi O, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-15
   Brielmaier J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040914
   BULFONE A, 1995, NEURON, V15, P63, DOI 10.1016/0896-6273(95)90065-9
   Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011
   Canitano R, 2011, PROG NEURO-PSYCHOPH, V35, P18, DOI 10.1016/j.pnpbp.2010.10.015
   Carrasco M, 2012, PEDIATRICS, V129, pE1301, DOI 10.1542/peds.2011-3285
   Carter MD, 2011, AUTISM RES, V4, P57, DOI 10.1002/aur.180
   Chahrour MH, 2012, PLOS GENET, V8, P236, DOI 10.1371/journal.pgen.1002635
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Cheh MA, 2006, BRAIN RES, V1116, P166, DOI 10.1016/j.brainres.2006.07.086
   Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906
   Chen WJA, 1998, ALCOHOL, V15, P33, DOI 10.1016/S0741-8329(97)00084-0
   Ching H, 2012, COCHRANE DB SYST REV, V5
   BAKKER CE, 1994, CELL, V78, P23
   Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008
   Cook EH, 1998, AM J HUM GENET, V62, P1077, DOI 10.1086/301832
   COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
   Crawley Jacqueline N, 2012, Dialogues Clin Neurosci, V14, P293
   Dani VS, 2005, P NATL ACAD SCI USA, V102, P12560, DOI 10.1073/pnas.0506071102
   Deane CM, 2002, MOL CELL PROTEOMICS, V1, P349, DOI 10.1074/mcp.M100037-MCP200
   DeLorey TM, 1998, J NEUROSCI, V18, P8505
   DeLorey TM, 2008, BEHAV BRAIN RES, V187, P207, DOI 10.1016/j.bbr.2007.09.009
   Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
   Dougherty JD, 2010, NUCLEIC ACIDS RES, V38, P4218, DOI 10.1093/nar/gkq130
   Dougherty JD, 2013, J NEUROSCI, V33, P2732, DOI 10.1523/JNEUROSCI.4762-12.2013
   Doyle JP, 2008, CELL, V135, P749, DOI 10.1016/j.cell.2008.10.029
   du Plessis L, 2011, BRIEF BIOINFORM, V12, P723, DOI 10.1093/bib/bbr002
   Ellegood Jacob, 2012, Front Psychiatry, V3, P37, DOI 10.3389/fpsyt.2012.00037
   Englund C, 2005, J NEUROSCI, V25, P247, DOI 10.1523/JNEUROSCI.2899-04.2005
   Fazzari P, 2007, BMC DEV BIOL, V7, DOI 10.1186/1471-213X-7-55
   Ferland RJ, 2003, J COMP NEUROL, V460, P266, DOI 10.1002/cne.10654
   Fisher SE, 2009, TRENDS GENET, V25, P166, DOI 10.1016/j.tig.2009.03.002
   Folstein S. E., 2003, NOVART FDN SYMP, V251, P80
   Folstein S. E., 2003, NOVART FDN SYMP, V251, P281
   Folstein S. E., 2003, NOVART FDN SYMP, V251, P109
   Folstein SE, 2003, NOVART FDN SYMP, V251, P70
   Fyffe SL, 2008, NEURON, V59, P947, DOI 10.1016/j.neuron.2008.07.030
   Gaub S, 2010, GENES BRAIN BEHAV, V9, P390, DOI 10.1111/j.1601-183X.2010.00570.x
   GERFEN CR, 1992, TRENDS NEUROSCI, V15, P133, DOI 10.1016/0166-2236(92)90355-C
   Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
   Gharani N, 2004, MOL PSYCHIATR, V9, P474, DOI 10.1038/sj.mp.4001498
   Giacometti E, 2007, P NATL ACAD SCI USA, V104, P1931, DOI 10.1073/pnas.0610593104
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Goffinet A M, 1984, Brain Res, V319, P261
   Gofflot Françoise, 2011, Curr Protoc Mouse Biol, V1, P1, DOI 10.1002/9780470942390.mo100103
   Gong SC, 2007, J NEUROSCI, V27, P9817, DOI 10.1523/JNEUROSCI.2707-07.2007
   GONZALORUIZ A, 1990, BRAIN RES BULL, V25, P919, DOI 10.1016/0361-9230(90)90189-7
   Gregorios-Pippas L, 2009, J NEUROPHYSIOL, V101, P1507, DOI 10.1152/jn.90730.2008
   Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899
   Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hamdan FF, 2010, AM J HUM GENET, V87, P671, DOI 10.1016/j.ajhg.2010.09.017
   Han S, 2012, NATURE, V489, P385, DOI 10.1038/nature11356
   Heiman M, 2008, CELL, V135, P738, DOI 10.1016/j.cell.2008.10.028
   Hendricks TJ, 2003, NEURON, V37, P233, DOI 10.1016/S0896-6273(02)01167-4
   Hofer M. A., 2002, CURR PROTOC NEUROSCI, V8, P14, DOI [DOI 10.1002/0471142301.NS0814S17, 10.1002/0471142301.ns0814s17.:Unit]
   Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Joung JK, 2013, NAT REV MOL CELL BIO, V14, P49, DOI 10.1038/nrm3486
   JOYNER AL, 1991, SCIENCE, V251, P1239, DOI 10.1126/science.1672471
   Jugloff DGM, 2008, HUM MOL GENET, V17, P1386, DOI 10.1093/hmg/ddn026
   Kalueff AV, 2007, GENES BRAIN BEHAV, V6, P389, DOI 10.1111/j.1601-183X.2006.00270.x
   Kane MJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048975
   KEMP JM, 1970, BRAIN, V93, P525, DOI 10.1093/brain/93.3.525
   Kirov G, 2012, MOL PSYCHIATR, V17, P142, DOI 10.1038/mp.2011.154
   Kirsten TB, 2012, J NEUROSCI RES, V90, P1903, DOI 10.1002/jnr.23089
   Klei L, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-9
   Koekkoek SKE, 2005, NEURON, V47, P339, DOI 10.1016/j.neuron.2005.07.005
   Kron M, 2012, J NEUROSCI, V32, P13860, DOI 10.1523/JNEUROSCI.2159-12.2012
   Kuppenbender KD, 2000, J COMP NEUROL, V419, P407, DOI 10.1002/(SICI)1096-9861(20000417)419:4<407::AID-CNE1>3.0.CO;2-I
   Kyzar EJ, 2012, BRAIN RES BULL, V89, P168, DOI 10.1016/j.brainresbull.2012.08.004
   Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
   LESCH KP, 1993, J NEUROCHEM, V60, P2319, DOI 10.1111/j.1471-4159.1993.tb03522.x
   Liljelund Patricia, 2005, Brain Res Dev Brain Res, V157, P150
   Limperopoulos C., 2012, CEREBRAL CORTEX
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luikenhuis S, 2004, P NATL ACAD SCI USA, V101, P6033, DOI 10.1073/pnas.0401626101
   Maezawa I, 2009, J NEUROSCI, V29, P5051, DOI [10.1523/JNEUROSCI.0324-09.2009, 10.1523/JNEUROSCI.324-09.2009]
   Markram H, 2004, NAT REV NEUROSCI, V5, P793, DOI 10.1038/nrn1519
   MCDOUGLE CJ, 1993, BIOL PSYCHIAT, V33, P547, DOI 10.1016/0006-3223(93)90011-2
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   McGraw CM, 2011, SCIENCE, V333, P186, DOI 10.1126/science.1206593
   Michaelson JJ, 2012, CELL, V151, P1431, DOI 10.1016/j.cell.2012.11.019
   Miczek KA, 2004, ANN NY ACAD SCI, V1036, P336, DOI 10.1196/annals.1330.021
   Middleton FA, 2001, J NEUROSCI, V21, P700
   Middleton FA, 2000, BRAIN COGNITION, V42, P183, DOI 10.1006/brcg.1999.1099
   MILLEN KJ, 1994, DEVELOPMENT, V120, P695
   Mosienko V, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.44
   Mossner R, 2006, NEUROSCI LETT, V401, P49, DOI 10.1016/j.neulet.2006.02.081
   Moy SS, 2008, BEHAV BRAIN RES, V191, P118, DOI 10.1016/j.bbr.2008.03.015
   Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x
   Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029
   Moy SS, 2006, AM J MED GENET C, V142C, P40, DOI 10.1002/ajmg.c.30081
   Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
   Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
   Mukamel Z, 2011, J NEUROSCI, V31, P11437, DOI 10.1523/JNEUROSCI.0181-11.2011
   Mullen BR, 2013, ASN NEURO, V5, P27, DOI 10.1042/AN20120060
   Nagy A, 2000, GENESIS, V26, P99, DOI 10.1002/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.3.CO;2-2
   Nakao T, 2005, PSYCHIAT RES-NEUROIM, V139, P101, DOI 10.1016/j.pscychresns.2004.12.004
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Newbury DF, 2010, NEURON, V68, P309, DOI 10.1016/j.neuron.2010.10.001
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Oswald DP, 2007, J CHILD ADOL PSYCHOP, V17, P348, DOI 10.1089/cap.2006.17303
   Page LA, 2009, PSYCHIAT RES-NEUROIM, V174, P202, DOI 10.1016/j.pscychresns.2009.05.002
   Panksepp JB, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000351
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Pellis SM, 1999, DEV PSYCHOBIOL, V34, P175, DOI 10.1002/(SICI)1098-2302(199904)34:3<175::AID-DEV2>3.0.CO;2-#
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Persico AM, 2013, BEHAV BRAIN RES, V251, P95, DOI 10.1016/j.bbr.2013.06.012
   Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850
   Pesold C, 1998, P NATL ACAD SCI USA, V95, P3221, DOI 10.1073/pnas.95.6.3221
   Peterson TC, 2012, BEHAV NEUROSCI, V126, P551, DOI 10.1037/a0028701
   Peyron C, 2000, NAT MED, V6, P991
   Rauch SL, 1997, J NEUROPSYCH CLIN N, V9, P568
   Reith RM, 2013, NEUROBIOL DIS, V51, P93, DOI 10.1016/j.nbd.2012.10.014
   RITVO ER, 1986, AM J PSYCHIAT, V143, P862
   Riva D, 2013, CEREBELLUM, V12, P676, DOI 10.1007/s12311-013-0469-8
   Rogers JT, 2013, J PSYCHOPHARMACOL, V27, P386, DOI 10.1177/0269881112463468
   Rogers TD, 2013, CEREBELLUM, V12, P547, DOI 10.1007/s12311-013-0462-2
   Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Saab CY, 2003, BRAIN RES REV, V42, P85, DOI 10.1016/S0165-0173(03)00151-6
   Salinger WL, 2003, BEHAV NEUROSCI, V117, P1257, DOI 10.1037/0735-7044.117.6.1257
   Samaco RC, 2009, P NATL ACAD SCI USA, V106, P21966, DOI 10.1073/pnas.0912257106
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sarna JR, 2003, PROG NEUROBIOL, V70, P473, DOI 10.1016/S0301-0082(03)00114-X
   Scattoni ML, 2008, BEHAV BRAIN RES, V187, P371, DOI 10.1016/j.bbr.2007.09.034
   Scattoni ML, 2013, BEHAV BRAIN RES, V251, P35, DOI 10.1016/j.bbr.2012.12.028
   Scattoni ML, 2011, GENES BRAIN BEHAV, V10, P44, DOI 10.1111/j.1601-183X.2010.00623.x
   Schaevitz LR, 2010, PHYSIOL BEHAV, V100, P255, DOI 10.1016/j.physbeh.2009.12.025
   SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8
   Schmahmann JD, 1998, BRAIN, V121, P561, DOI 10.1093/brain/121.4.561
   Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2
   Sen B, 2010, GENES BRAIN BEHAV, V9, P248, DOI 10.1111/j.1601-183X.2009.00556.x
   Shahbazian MD, 2002, NEURON, V35, P243, DOI 10.1016/S0896-6273(02)00768-7
   Sheng M, 2000, J CELL SCI, V113, P1851
   Shu WG, 2005, P NATL ACAD SCI USA, V102, P9643, DOI 10.1073/pnas.0503739102
   Sillitoe RV, 2008, J NEUROSCI, V28, P12150, DOI 10.1523/JNEUROSCI.2059-08.2008
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Staal WG, 2012, J AUTISM DEV DISORD, V42, P885, DOI 10.1007/s10803-011-1312-z
   Stocco A, 2010, PSYCHOL REV, V117, P541, DOI 10.1037/a0019077
   Takahashi K, 2003, J NEUROSCI RES, V73, P61, DOI 10.1002/jnr.10638
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Tamura S, 2004, NEUROSCIENCE, V124, P261, DOI 10.1016/j.neuroscience.2003.11.036
   Taniguchi H, 2011, NEURON, V71, P995, DOI 10.1016/j.neuron.2011.07.026
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   Trouillas P, 1997, J NEUROL SCI, V145, P205, DOI 10.1016/S0022-510X(96)00231-6
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   Ubeda-Banon I, 2007, BMC NEUROSCI, V8, DOI 10.1186/1471-2202-8-103
   Ugarte SD, 2000, NEUROSCIENCE, V95, P795
   van den Heuvel OA, 2005, ARCH GEN PSYCHIAT, V62, P301, DOI 10.1001/archpsyc.62.3.301
   Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109
   Vernes SC, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002145
   Verpelli C, 2011, J BIOL CHEM, V286, P34839, DOI 10.1074/jbc.M111.258384
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   WAGSTAFF J, 1991, AM J HUM GENET, V49, P330
   Waider J, 2013, HISTOCHEM CELL BIOL, V139, P267, DOI 10.1007/s00418-012-1029-x
   Wang HY, 2013, CELL, V153, P910, DOI 10.1016/j.cell.2013.04.025
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Wang XM, 2011, HUM MOL GENET, V20, P3093, DOI 10.1093/hmg/ddr212
   Wegiel J, 2013, BRAIN RES, V1512, P106, DOI 10.1016/j.brainres.2013.03.037
   Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
   Welch JM, 2004, J COMP NEUROL, V472, P24, DOI 10.1002/cne.20060
   Whiteside SP, 2004, PSYCHIAT RES-NEUROIM, V132, P69, DOI 10.1016/j.pscychresns.2004.07.001
   Willins DL, 1997, SYNAPSE, V27, P79, DOI 10.1002/(SICI)1098-2396(199709)27:1<79::AID-SYN8>3.0.CO;2-A
   Wohr M, 2013, BEHAV BRAIN RES, V251, P5, DOI 10.1016/j.bbr.2013.05.047
   YAMAMOTO T, 1992, BRAIN RES, V579, P315, DOI 10.1016/0006-8993(92)90067-J
   Yang M, 2012, J NEUROSCI, V32, P6525, DOI 10.1523/JNEUROSCI.6107-11.2012
   Zhang L, 2008, HIPPOCAMPUS, V18, P294, DOI 10.1002/hipo.20389
   Zhang S, 2007, NEUROSCIENCE, V148, P34, DOI 10.1016/j.neuroscience.2007.05.029
   Zhou FC, 2002, BRAIN RES, V942, P109, DOI 10.1016/S0006-8993(02)02709-9
NR 193
TC 1
Z9 1
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 61
EP 96
DI 10.1016/B978-0-12-418700-9.00003-4
PG 36
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100004
PM 24290383
ER

PT S
AU Lepp, S
   Anderson, A
   Konopka, G
AF Lepp, Stephanie
   Anderson, Ashley
   Konopka, Genevieve
BE Konopka, G
TI Connecting Signaling Pathways Underlying Communication to ASD
   Vulnerability
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID AUTISM SPECTRUM DISORDERS; DE-NOVO MUTATIONS; ESSENTIAL TRANSCRIPTIONAL
   REGULATOR; ZINC-FINGER NUCLEASES; FOXP2 GENE; SPEECH DELAY; HUMAN
   GENOME; LANGUAGE IMPAIRMENT; SUSCEPTIBILITY GENE; HUMAN BRAIN
AB Language is a human-specific trait that likely facilitated the rapid increase in higher cognitive function in our species. A consequence of the selective pressures that have permitted language and cognition to flourish in humans is the unique vulnerability of humans to developing cognitive disorders such as autism. Therefore, progress in understanding the genetic and molecular mechanisms of language evolution should provide insight into such disorders. Here, we discuss the few genes that have been identified in both autism-related pathways and language. We also detail the use of animal models to uncover the function of these genes at a mechanistic and circuit level. Finally, we present the use of comparative genomics to identify novel genes and gene networks involved in autism. Together, all of these approaches will allow for a broader and deeper view of the molecular brain mechanisms involved in the evolution of language and the gene disruptions associated with autism.
C1 [Lepp, Stephanie; Anderson, Ashley; Konopka, Genevieve] UT Southwestern Med Ctr, Dept Neurosci, Dallas, TX 75390 USA.
RP Konopka, G (reprint author), UT Southwestern Med Ctr, Dept Neurosci, Dallas, TX 75390 USA.
EM genevieve.konopka@utsouthwestern.edu
CR Abrahams BS, 2007, P NATL ACAD SCI USA, V104, P17849, DOI 10.1073/pnas.0706128104
   Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
   Alarcon M, 2002, AM J HUM GENET, V70, P60, DOI 10.1086/338241
   Al-Murrani A, 2012, CASE REP GENET, V2012
   Anderson GR, 2012, P NATL ACAD SCI USA, V109, P18120, DOI 10.1073/pnas.1216398109
   Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
   Arriaga G, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046610
   Arriaga G, 2013, BRAIN LANG, V124, P96, DOI 10.1016/j.bandl.2012.10.002
   Bacon C, 2012, HUM GENET, V131, P1687, DOI 10.1007/s00439-012-1193-z
   Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
   Barttfeld P, 2011, NEUROPSYCHOLOGIA, V49, P254, DOI 10.1016/j.neuropsychologia.2010.11.024
   Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835
   Benavides-Piccione R, 2002, J NEUROCYTOL, V31, P337, DOI 10.1023/A:1024134312173
   Berg JM, 2012, GENOME BIOL, V13, DOI [10.1186/gb4034, 10.1186/gb-2012-13-7-247]
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Dunham I, 2012, NATURE, V489, P57, DOI 10.1038/nature11247
   Bowers J. M., 2012, AUTISM OPEN ACCESS S, VS1
   Bowers JM, 2013, J NEUROSCI, V33, P3276, DOI 10.1523/JNEUROSCI.0425-12.2013
   Bowers JM, 2012, DIS MARKERS, V33, P251, DOI 10.3233/DMA-2012-0919
   Campbell AJ, 2010, BRIT J HAEMATOL, V149, P221, DOI 10.1111/j.1365-2141.2009.08070.x
   Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27
   Carr CW, 2010, EUR J HUM GENET, V18, P1216, DOI 10.1038/ejhg.2010.96
   Casey JP, 2012, HUM GENET, V131, P565, DOI 10.1007/s00439-011-1094-6
   Chien YL, 2011, PROG NEURO-PSYCHOPH, V35, P1512, DOI 10.1016/j.pnpbp.2011.04.010
   Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
   Crespi B, 2007, P ROY SOC B-BIOL SCI, V274, P2801, DOI 10.1098/rspb.2007.0876
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P261, DOI 10.1017/S0140525X08004214
   Crespi B, 2008, BIOL REV, V83, P441, DOI 10.1111/j.1469-185X.2008.00050.x
   Crosson B, 2013, BRAIN LANG, V126, P73, DOI 10.1016/j.bandl.2012.06.011
   Crow TJ, 1997, SCHIZOPHR RES, V28, P127, DOI 10.1016/S0920-9964(97)00110-2
   Dasen JS, 2008, CELL, V134, P304, DOI 10.1016/j.cell.2008.06.019
   De Felipe J., 2001, J NEUROSCI, V21, P163
   Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
   Dumontheil I, 2008, DEV MED CHILD NEUROL, V50, P168, DOI 10.1111/j.1469-8749.2008.02026.x
   Eagleson KL, 2011, AUTISM RES, V4, P68, DOI 10.1002/aur.172
   Ehret G, 2005, BEHAV GENET, V35, P19, DOI 10.1007/s10519-004-0853-8
   Enard W, 2009, CELL, V137, P961, DOI 10.1016/j.cell.2009.03.041
   Enard W, 2002, NATURE, V418, P869, DOI 10.1038/nature01025
   Feng XM, 2010, BLOOD, V115, P510, DOI 10.1182/blood-2009-07-232694
   Ferland RJ, 2003, J COMP NEUROL, V460, P266, DOI 10.1002/cne.10654
   Feuk L, 2006, AM J HUM GENET, V79, P965, DOI 10.1086/508902
   Ford Anastasia A, 2013, Front Neuroanat, V7, P8, DOI 10.3389/fnana.2013.00008
   French CA, 2007, GENESIS, V45, P440, DOI 10.1002/dvg.20305
   Gaj T, 2013, TRENDS BIOTECHNOL, V31, P397, DOI 10.1016/j.tibtech.2013.04.004
   Gaub S, 2010, GENES BRAIN BEHAV, V9, P390, DOI 10.1111/j.1601-183X.2010.00570.x
   Gauthier J, 2003, AM J MED GENET A, V118A, P172, DOI 10.1002/ajmg.a.10105
   Geurts AM, 2009, SCIENCE, V325, P433, DOI 10.1126/science.1172447
   Gibney SM, 2013, J NEUROIMMUNE PHARM, V8, P900, DOI 10.1007/s11481-013-9462-8
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Gong XH, 2004, AM J MED GENET B, V127B, P113, DOI 10.1002/ajmg.b.20162
   Cong L, 2013, SCIENCE, V339, P819, DOI 10.1126/science.1231143
   Haesler S, 2007, PLOS BIOL, V5, P2885, DOI 10.1371/journal.pbio.0050321
   Hahn ME, 2005, BEHAV GENET, V35, P31, DOI 10.1007/s10519-004-0854-7
   Hahn ME, 1998, BEHAV GENET, V28, P315, DOI 10.1023/A:1021679615792
   Hamdan FF, 2010, AM J HUM GENET, V87, P671, DOI 10.1016/j.ajhg.2010.09.017
   Hammerschmidt K, 2009, BIOL LETTERS, V5, P589, DOI 10.1098/rsbl.2009.0317
   Hauser MD, 2002, SCIENCE, V298, P1569, DOI 10.1126/science.298.5598.1569
   Hawrylycz MJ, 2012, NATURE, V489, P391, DOI 10.1038/nature11405
   Hilliard AT, 2012, NEURON, V73, P537, DOI 10.1016/j.neuron.2012.01.005
   Holy TE, 2005, PLOS BIOL, V3, P2177, DOI 10.1371/journal.pbio.0030386
   Horn D, 2010, HUM MUTAT, V31, pE1851, DOI 10.1002/humu.21362
   Hu H, 2006, NAT IMMUNOL, V7, P819, DOI 10.1038/ni1358
   Huang GY, 2011, CELL CYCLE, V10, P1059, DOI 10.4161/cc.10.7.15233
   Jackman C, 2009, PEDIATR NEUROL, V40, P310, DOI 10.1016/j.pediatrneurol.2008.10.013
   Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   JONAS S, 1982, J COMMUN DISORD, V15, P31, DOI 10.1016/0021-9924(82)90042-9
   Keller SS, 2009, BRAIN LANG, V109, P29, DOI 10.1016/j.bandl.2008.11.005
   King BH, 2011, BRAIN RES, V1380, P34, DOI 10.1016/j.brainres.2010.11.031
   Konopka G, 2012, MOL PSYCHIATR, V17, P202, DOI 10.1038/mp.2011.60
   Konopka G, 2009, NATURE, V462, P213, DOI 10.1038/nature08549
   Konopka G, 2012, NEURON, V75, P601, DOI 10.1016/j.neuron.2012.05.034
   Kos M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046995
   Kotz SA, 2009, CORTEX, V45, P982, DOI 10.1016/j.cortex.2009.02.010
   Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
   Langfelder P, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-559
   Laroche F, 2008, PSYCHIAT GENET, V18, P295, DOI 10.1097/YPG.0b013e3283060fa5
   LeBlanc JJ, 2011, NEURAL PLAST, DOI 10.1155/2011/921680
   Li H, 2005, BRAIN DEV-JPN, V27, P207, DOI 10.1016/j.braindev.2004.06.002
   Li SR, 2004, MOL CELL BIOL, V24, P809, DOI 10.1128/MCB.24.2.809-822.2004
   Li T, 2011, NUCLEIC ACIDS RES, V39, P6315, DOI 10.1093/nar/gkr188
   Li XB, 2009, CURR OPIN PSYCHIATR, V22, P131, DOI 10.1097/YCO.0b013e328324bc43
   Li XP, 2010, PSYCHIAT GENET, V20, P113, DOI 10.1097/YPG.0b013e32833a216f
   Lieberman P, 2002, YEARB PHYS ANTHROPOL, V45, P36, DOI 10.1002/ajpa.10171
   Lin PI, 2012, RES DEV DISABIL, V33, P1533, DOI 10.1016/j.ridd.2012.03.004
   Lipkind D, 2013, NATURE, V498, P104, DOI 10.1038/nature12173
   Liu XL, 2012, GENOME RES, V22, P611, DOI 10.1101/gr.127324.111
   Mali P, 2013, SCIENCE, V339, P823, DOI 10.1126/science.1232033
   Maricic T, 2013, MOL BIOL EVOL, V30, P844, DOI 10.1093/molbev/mss271
   Marson A, 2007, NATURE, V445, P931, DOI 10.1038/nature05478
   Marui T, 2005, NEUROSCI RES, V53, P91, DOI 10.1016/j.neures.2005.05.003
   Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
   Michel M, 2012, DEV NEUROBIOL, V72, P1277, DOI 10.1002/dneu.22044
   Moehle EA, 2007, P NATL ACAD SCI USA, V104, P3055, DOI 10.1073/pnas.0611478104
   Moles A, 2007, BEHAV BRAIN RES, V182, P223, DOI 10.1016/j.bbr.2007.01.020
   Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
   Moorman S, 2012, P NATL ACAD SCI USA, V109, P12782, DOI 10.1073/pnas.1207207109
   MORICE RD, 1983, PSYCHIAT RES, V9, P233, DOI 10.1016/0165-1781(83)90048-3
   Mukamel Z, 2011, J NEUROSCI, V31, P11437, DOI 10.1523/JNEUROSCI.0181-11.2011
   Nair A, 2013, BRAIN, V136, P1942, DOI 10.1093/brain/awt079
   Nelson CS, 2013, NUCLEIC ACIDS RES, V41, P5991, DOI 10.1093/nar/gkt259
   Newbury DF, 2002, AM J HUM GENET, V70, P1318, DOI 10.1086/339931
   OJEMANN GA, 1991, J NEUROSCI, V11, P2281
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Panaitof SC, 2010, J COMP NEUROL, V518, P1995, DOI 10.1002/cne.22318
   Pariani MJ, 2009, EUR J MED GENET, V52, P123, DOI 10.1016/j.ejmg.2009.03.012
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Penn D. C., 2008, BEHAV BRAIN SCI, V31, P130
   Penn DC, 2008, BEHAV BRAIN SCI, V31, P109, DOI 10.1017/S0140525X08003543
   Penzes P, 2013, J NEUROCHEM, V126, P165, DOI 10.1111/jnc.12261
   Petkov Christopher I, 2012, Front Evol Neurosci, V4, P12, DOI 10.3389/fnevo.2012.00012
   Pinker S, 2005, COGNITION, V95, P201, DOI 10.1016/j.cognition.2004.08.004
   Poliak S, 2003, J CELL BIOL, V162, P1149, DOI 10.1083/jcb.200305018
   Poliak S, 1999, NEURON, V24, P1037, DOI 10.1016/S0896-6273(00)81049-1
   POMERANTZ SM, 1983, PHYSIOL BEHAV, V31, P91, DOI 10.1016/0031-9384(83)90101-4
   Poot M, 2010, NEUROGENETICS, V11, P81, DOI 10.1007/s10048-009-0205-1
   Premack D, 2007, P NATL ACAD SCI USA, V104, P13861, DOI 10.1073/pnas.0706147104
   Rapoport JL, 2005, MOL PSYCHIATR, V10, P434, DOI 10.1038/sj.mp.4001642
   Richler E, 2006, PSYCHIAT GENET, V16, P19, DOI 10.1097/01.ypg.0000180683.18665.ef
   Rogers Tiffany D, 2013, Front Syst Neurosci, V7, P15, DOI 10.3389/fnsys.2013.00015
   Roll P, 2010, HUM MOL GENET, V19, P4848, DOI 10.1093/hmg/ddq415
   Rousso DL, 2008, NEURON, V59, P226, DOI 10.1016/j.neuron.2008.06.025
   Sakai Y, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002166
   Sanjuan J, 2005, SCHIZOPHR RES, V73, P253, DOI 10.1016/j.schres.2004.05.012
   Sanjuan J, 2006, PSYCHIAT GENET, V16, P67, DOI 10.1097/01.ypg.0000185029.35558.bb
   Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
   Scott-Van Zeeland AA, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3001344
   Shepherd GMG, 2013, NAT REV NEUROSCI, V14, P278, DOI 10.1038/nrn3469
   Shi F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063131
   Shu WG, 2005, P NATL ACAD SCI USA, V102, P9643, DOI 10.1073/pnas.0503739102
   Shu WG, 2001, J BIOL CHEM, V276, P27488, DOI 10.1074/jbc.M100636200
   Spiteri E, 2007, AM J HUM GENET, V81, P1144, DOI 10.1086/522237
   Spocter MA, 2010, P ROY SOC B-BIOL SCI, V277, P2165, DOI 10.1098/rspb.2010.0011
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   Strauss KA, 2006, NEW ENGL J MED, V354, P1370, DOI 10.1056/NEJMoa052773
   Sugranyes G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025322
   Surmeli G, 2011, CELL, V147, P653, DOI 10.1016/j.cell.2011.10.012
   Takahashi K, 2008, J NEUROSCI RES, V86, P3106, DOI 10.1002/jnr.21770
   Takahashi K, 2008, J COMP NEUROL, V509, P180, DOI 10.1002/cne.21740
   Takahashi K, 2003, J NEUROSCI RES, V73, P61, DOI 10.1002/jnr.10638
   Tang B, 2012, HUM MOL GENET, V21, P3097, DOI 10.1093/hmg/dds132
   Teramitsu I, 2004, J NEUROSCI, V24, P3152, DOI 10.1523/JNEUROSCI.5589-03.2004
   Tolosa A, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-114
   Toma C, 2013, PSYCHIAT GENET, V23, P82, DOI 10.1097/YPG.0b013e32835d6fc6
   Tsui D, 2013, J NEUROSCI, V33, P244, DOI 10.1523/JNEUROSCI.1665-12.2013
   van Os J, 2009, LANCET, V374, P635, DOI 10.1016/S0140-6736(09)60995-8
   Vargha-Khadem F, 2005, NAT REV NEUROSCI, V6, P131, DOI 10.1038/nrn1605
   VARGHAKHADEM F, 1995, P NATL ACAD SCI USA, V92, P930, DOI 10.1073/pnas.92.3.930
   Vernes SC, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002145
   Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
   Vernes SC, 2007, AM J HUM GENET, V81, P1232, DOI 10.1086/522238
   Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Walker RM, 2012, HUM MOL GENET, V21, P2862, DOI 10.1093/hmg/dds111
   Walsh CA, 2010, NEURON, V68, P245, DOI 10.1016/j.neuron.2010.09.042
   Wang B, 2004, DEVELOPMENT, V131, P4477, DOI 10.1242/dev.01287
   Wang Guang-Zhong, 2013, Transcription, V4, P102
   Wassink TH, 2002, AM J MED GENET, V114, P566, DOI 10.1002/ajmg.10415
   Watkins KE, 2002, BRAIN, V125, P452, DOI 10.1093/brain/awf058
   Wei CL, 2006, CELL, V124, P207, DOI 10.1016/j.cell.2005.10.043
   Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
   Xu L, 2011, NUCLEIC ACIDS RES, V40, pD1016
   Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
   Zhang B, 2005, STAT APPL GENET MO B, V4, DOI 10.2202/1544-6115.1128
   Zhang JZ, 2002, GENETICS, V162, P1825
   Zweier C, 2009, AM J HUM GENET, V85, P655, DOI 10.1016/j.ajhg.2009.10.004
NR 169
TC 2
Z9 2
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 97
EP 133
DI 10.1016/B978-0-12-418700-9.00004-6
PG 37
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100005
PM 24290384
ER

PT S
AU Peng, Y
   Huentelman, M
   Smith, C
   Qiu, SF
AF Peng, Yun
   Huentelman, Matthew
   Smith, Christopher
   Qiu, Shenfeng
BE Konopka, G
TI MET Receptor Tyrosine Kinase as an Autism Genetic Risk Factor
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID HEPATOCYTE GROWTH-FACTOR; FACTOR-SCATTER FACTOR;
   INFLAMMATORY-BOWEL-DISEASE; HIGH-FUNCTIONING AUTISM; C-MET; SPECTRUM
   DISORDER; FACTOR/SCATTER FACTOR; HIPPOCAMPAL-NEURONS; NEUROTROPHIC
   FACTOR; AXONAL GROWTH
AB In this chapter, we will briefly discuss recent literature on the role of MET receptor tyrosine kinase (RTK) in brain development and how perturbation of MET signaling may alter normal neurodevelopmental outcomes. Recent human genetic studies have established MET as a risk factor for autism, and the molecular and cellular underpinnings of this genetic risk are only beginning to emerge from obscurity. Unlike many autism risk genes that encode synaptic proteins, the spatial and temporal expression pattern of MET RTK indicates this signaling system is ideally situated to regulate neuronal growth, functional maturation, and establishment of functional brain circuits, particularly in those brain structures involved in higher levels of cognition, social skills, and executive functions.
C1 [Peng, Yun; Qiu, Shenfeng] Univ Arizona, Dept Basic Med Sci, Coll Med, Phoenix, AZ 85004 USA.
   [Huentelman, Matthew] Translat Genom Res Inst, Neurogen Div, Phoenix, AZ USA.
   [Smith, Christopher] Southwest Autism Res Ctr, Phoenix, AZ USA.
RP Qiu, SF (reprint author), Univ Arizona, Dept Basic Med Sci, Coll Med, Phoenix, AZ 85004 USA.
EM sqiu@email.arizona.edu
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Akimoto M, 2004, NEUROSCIENCE, V128, P155, DOI 10.1016/j.neuroscience.2004.06.031
   Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
   Aldinger Kimberly A, 2011, Neuron, V72, P418, DOI 10.1016/j.neuron.2011.10.007
   Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190
   Arthur LG, 2004, J PEDIATR SURG, V39, P139, DOI 10.1016/j.jpedsurg.2003.10.001
   Bai L, 2012, NAT NEUROSCI, V15, P862, DOI 10.1038/nn.3109
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Beilmann M, 2000, BLOOD, V95, P3964
   Birchmeier C, 2003, NAT REV MOL CELL BIO, V4, P915, DOI 10.1038/nrm1261
   BLADT F, 1995, NATURE, V376, P768, DOI 10.1038/376768a0
   Boccaccio C, 1998, NATURE, V391, P285, DOI 10.1038/34657
   BOTTARO DP, 1991, SCIENCE, V251, P802, DOI 10.1126/science.1846706
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   Bradke F, 2000, CURR OPIN NEUROBIOL, V10, P574, DOI 10.1016/S0959-4388(00)00124-0
   BRONNERFRASER M, 1995, TRENDS GENET, V11, P423, DOI 10.1016/S0168-9525(00)89136-2
   Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103
   Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180
   Campbell DB, 2009, PEDIATRICS, V123, P1018, DOI 10.1542/peds.2008-0819
   Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27
   Caton A, 2000, DEVELOPMENT, V127, P1751
   Clement JP, 2012, CELL, V151, P709, DOI 10.1016/j.cell.2012.08.045
   Constantino JN, 2013, MOL PSYCHIATR, V18, P137, DOI 10.1038/mp.2012.9
   COOPER CS, 1984, NATURE, V311, P29, DOI 10.1038/311029a0
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   CRAIG AM, 1994, ANNU REV NEUROSCI, V17, P267, DOI 10.1146/annurev.neuro.17.1.267
   Davey F, 2000, MOL CELL NEUROSCI, V15, P79, DOI 10.1006/mcne.1999.0803
   DIRENZO MF, 1993, ONCOGENE, V8, P219
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Eagleson KL, 2013, J COMP NEUROL, V521, P3241, DOI 10.1002/cne.23343
   Eagleson KL, 2005, J COMP NEUROL, V489, P449, DOI 10.1002/cne.20647
   Ebens A, 1996, NEURON, V17, P1157, DOI 10.1016/S0896-6273(00)80247-0
   Ebert DH, 2013, NATURE, V493, P327, DOI 10.1038/nature11860
   FALETTO DL, 1992, ONCOGENE, V7, P1149
   Fan SJ, 2001, MOL CELL BIOL, V21, P4968, DOI 10.1128/MCB.21.15.4968-4984.2001
   Furge KA, 2000, ONCOGENE, V19, P5582, DOI 10.1038/sj.onc.1203859
   Garzotto D, 2008, J NEUROSCI, V28, P5901, DOI 10.1523/JNEUROSCI.1083-08.2008
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Giacobini P, 2007, J NEUROSCI, V27, P431, DOI 10.1523/JNEUROSCI.4979-06.2007
   Gorski JA, 2002, J NEUROSCI, V22, P6309
   Gual P, 2000, ONCOGENE, V19, P1509, DOI 10.1038/sj.onc.1203514
   Gutierrez H, 2004, DEVELOPMENT, V131, P3717, DOI 10.1242/dev.01209
   Hong SS, 2011, PSYCHIAT RES-NEUROIM, V194, P333, DOI 10.1016/j.pscychresns.2011.03.009
   Huh CG, 2004, P NATL ACAD SCI USA, V101, P4477, DOI 10.1073/pnas.0306068101
   Ido A, 2005, J GASTROENTEROL, V40, P925, DOI 10.1007/s00535-005-1705-x
   Ieraci A, 2002, P NATL ACAD SCI USA, V99, P15200, DOI 10.1073/pnas.222362099
   Bailey A, 1998, HUM MOL GENET, V7, P571
   Palferman S, 2001, HUM MOL GENET, V10, P973
   Ishigaki A, 2007, J NEUROPATH EXP NEUR, V66, P1037, DOI 10.1097/nen.0b013e318159886b
   Jackson PB, 2009, AUTISM RES, V2, P232, DOI 10.1002/aur.87
   Judson MC, 2011, CEREB CORTEX, V21, P1613, DOI 10.1093/cercor/bhq223
   Judson MC, 2011, J NEURODEV DISORD, V3, P282, DOI 10.1007/s11689-011-9081-8
   Judson MC, 2009, J COMP NEUROL, V513, P511, DOI 10.1002/cne.21969
   Judson MC, 2010, J COMP NEUROL, V518, P4463, DOI 10.1002/cne.22467
   JUNG W, 1994, J CELL BIOL, V126, P485, DOI 10.1083/jcb.126.2.485
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Kana RK, 2009, SOC NEUROSCI-UK, V4, P135, DOI 10.1080/17470910802198510
   Kawas LH, 2013, NANOMED-NANOTECHNOL, V9, P428, DOI 10.1016/j.nano.2012.08.008
   Kitamura K, 2007, J NEUROSCI RES, V85, P2332, DOI 10.1002/jnr.21372
   KRASNOSELSKY A, 1994, J NEUROSCI, V14, P7284
   Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
   Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
   Lim CS, 2008, CELL SIGNAL, V20, P825, DOI 10.1016/j.cellsig.2007.12.013
   Luo L, 2008, NEURON, V57, P634, DOI 10.1016/j.neuron.2008.01.002
   Maina F, 1997, GENE DEV, V11, P3341, DOI 10.1101/gad.11.24.3341
   Maina F, 1996, CELL, V87, P531, DOI 10.1016/S0092-8674(00)81372-0
   Maina F, 2001, MOL CELL, V7, P1293, DOI 10.1016/S1097-2765(01)00261-1
   Maina F, 1998, NEURON, V20, P835, DOI 10.1016/S0896-6273(00)80466-3
   MARSHALL CJ, 1995, CELL, V80, P179, DOI 10.1016/0092-8674(95)90401-8
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Matsuzaki M, 2001, NAT NEUROSCI, V4, P1086, DOI 10.1038/nn736
   Miyazawa T, 1998, J CEREBR BLOOD F MET, V18, P345
   Monga SPS, 2002, CANCER RES, V62, P2064
   Moumen A, 2007, HEPATOLOGY, V45, P1210, DOI 10.1002/hep.21604
   Mueller BK, 1999, ANNU REV NEUROSCI, V22, P351, DOI 10.1146/annurev.neuro.22.1.351
   Mukamel Z, 2011, J NEUROSCI, V31, P11437, DOI 10.1523/JNEUROSCI.0181-11.2011
   Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024
   NALDINI L, 1991, MOL CELL BIOL, V11, P1793
   NALDINI L, 1991, EMBO J, V10, P2867
   O'Brien LE, 2004, DEV CELL, V7, P21, DOI 10.1016/j.devcel.2004.06.001
   Okunishi K, 2005, J IMMUNOL, V175, P4745
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Petreanu L, 2007, NAT NEUROSCI, V10, P663, DOI 10.1038/nn1891
   Piggot J, 2009, NEUROSCIENCE, V164, P247, DOI 10.1016/j.neuroscience.2009.05.054
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   PONZETTO C, 1994, CELL, V77, P261, DOI 10.1016/0092-8674(94)90318-2
   Ponzetto C, 1996, J BIOL CHEM, V271, P14119
   Powell EM, 2001, NEURON, V30, P79, DOI 10.1016/S0896-6273(01)00264-1
   Powell EM, 2003, J NEUROSCI, V23, P622
   Powell EM, 2003, DEV NEUROSCI-BASEL, V25, P197, DOI 10.1159/000072268
   Pozo K, 2010, NEURON, V66, P337, DOI 10.1016/j.neuron.2010.04.028
   Qiu SF, 2012, DEV NEUROSCI-BASEL, V34, P88, DOI 10.1159/000336644
   Qiu SF, 2011, J NEUROSCI, V31, P5855, DOI 10.1523/JNEUROSCI.6569-10.2011
   Robinson DR, 2000, ONCOGENE, V19, P5548, DOI 10.1038/sj.onc.1203957
   Roccisana J, 2005, DIABETES, V54, P2090, DOI 10.2337/diabetes.54.7.2090
   Royal I, 2000, MOL BIOL CELL, V11, P1709
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Rudie JD, 2012, NEURON, V75, P904, DOI 10.1016/j.neuron.2012.07.010
   Sahyoun CP, 2010, NEUROPSYCHOLOGIA, V48, P86, DOI 10.1016/j.neuropsychologia.2009.08.013
   Salian-Mehta S, 2013, MOL CELL ENDOCRINOL, V374, P92, DOI 10.1016/j.mce.2013.04.018
   SCHMIDT C, 1995, NATURE, V373, P699, DOI 10.1038/373699a0
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Segarra J, 2006, J BIOL CHEM, V281, P4771, DOI 10.1074/jbc.M508298200
   Shukla DK, 2011, NEUROPSYCHOLOGIA, V49, P1378, DOI 10.1016/j.neuropsychologia.2011.02.022
   Shukla DK, 2011, J CHILD PSYCHOL PSYC, V52, P286, DOI 10.1111/j.1469-7610.2010.02342.x
   Sousa I, 2009, EUR J HUM GENET, V17, P749, DOI 10.1038/ejhg.2008.215
   STREIT A, 1995, DEVELOPMENT, V121, P813
   Sun W, 2002, J NEUROSCI, V22, P6537
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Tahara Y, 2003, J PHARMACOL EXP THER, V307, P146, DOI 10.1124/jpet.103.054106
   TAKAISHI K, 1994, ONCOGENE, V9, P273
   TEMPEST PR, 1988, BRIT J CANCER, V58, P3, DOI 10.1038/bjc.1988.150
   TessierLavigne M, 1996, SCIENCE, V274, P1123, DOI 10.1126/science.274.5290.1123
   Thanseem I, 2010, NEUROSCI RES, V68, P137, DOI 10.1016/j.neures.2010.06.014
   Thewke DP, 1999, BRAIN RES, V821, P356, DOI 10.1016/S0006-8993(99)01115-4
   Thomas C, 2011, CORTEX, V47, P863, DOI 10.1016/j.cortex.2010.07.006
   Turrigiano GG, 2000, CURR OPIN NEUROBIOL, V10, P358, DOI 10.1016/S0959-4388(00)00091-X
   Tyndall SJ, 2006, CELL CYCLE, V5, P1560, DOI 10.4161/cc.5.14.2918
   Tyndall SJ, 2007, J NEUROSCI RES, V85, P2343, DOI 10.1002/jnr.21390
   UEHARA Y, 1995, NATURE, V373, P702, DOI 10.1038/373702a0
   Walsh CA, 2008, CELL, V135, P396, DOI 10.1016/j.cell.2008.10.015
   Wong VV, 1997, J BIOL CHEM, V272, P5187
   Wu HH, 2013, DEV NEUROSCI-BASEL, V35, P1, DOI 10.1159/000346367
   Yamamoto Y, 1997, DEVELOPMENT, V124, P2903
   Yang XM, 1998, J NEUROSCI, V18, P8369
   Yashiro K, 2009, NAT NEUROSCI, V12, P777, DOI 10.1038/nn.2327
   Yonan AL, 2003, AM J HUM GENET, V73, P886, DOI 10.1086/378778
NR 128
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 135
EP 165
DI 10.1016/B978-0-12-418700-9.00005-8
PG 31
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100006
PM 24290385
ER

PT S
AU Kwan, KY
AF Kwan, Kenneth Y.
BE Konopka, G
TI Transcriptional Dysregulation of Neocortical Circuit Assembly in ASD
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID AUTISM SPECTRUM DISORDERS; DEVELOPING CEREBRAL-CORTEX; DE-NOVO
   MUTATIONS; CENTRAL-NERVOUS-SYSTEM; SUBCORTICAL PROJECTION NEURONS; GENE
   FEZ-LIKE; WHITE-MATTER; RADIAL GLIA; HUMAN BRAIN; INTELLECTUAL
   DISABILITY
AB Autism spectrum disorders (ASDs) impair social cognition and communication, key higher-order functions centered in the human neocortex. The assembly of neocortical circuitry is a precisely regulated developmental process susceptible to genetic alterations that can ultimately affect cognitive abilities. Because ASD is an early onset neurodevelopmental disorder that disrupts functions executed by the neocortex, miswiring of neocortical circuits has been hypothesized to be an underlying mechanism of ASD. This possibility is supported by emerging genetic findings and data from imaging studies. Recent research on neocortical development has identified transcription factors as key determinants of neocortical circuit assembly, mediating diverse processes including neuronal specification, migration, and wiring. Many of these TFs (TBR1, SOX5, FEZF2, and SATB2) have been implicated in ASD. Here, I will discuss the functional roles of these transcriptional programs in neocortical circuit development and their neurobiological implications for the emerging etiology of ASD.
C1 Univ Michigan, Dept Human Genet, MBNI, Ann Arbor, MI 48109 USA.
RP Kwan, KY (reprint author), Univ Michigan, Dept Human Genet, MBNI, Ann Arbor, MI 48109 USA.
EM kykwan@umich.edu
CR Alcamo EA, 2008, NEURON, V57, P364, DOI 10.1016/j.neuron.2007.12.012
   Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032
   ALLENDOERFER KL, 1994, ANNU REV NEUROSCI, V17, P185, DOI 10.1146/annurev.neuro.17.1.185
   Anderson SA, 1997, SCIENCE, V278, P474, DOI 10.1126/science.278.5337.474
   Ang ESBC, 2003, J NEUROSCI, V23, P5805
   ANGEVINE JB, 1961, NATURE, V192, P766, DOI 10.1038/192766b0
   ANGEVINE JB, 1970, ANAT REC, V166, P257, DOI 10.1002/ar.1091660214
   Anthony TE, 2004, NEURON, V41, P881, DOI 10.1016/S0896-6273(04)00140-0
   Anton ES, 1999, NEURON, V22, P277, DOI 10.1016/S0896-6273(00)81089-2
   Arlotta P, 2005, NEURON, V45, P207, DOI 10.1016/j.neuron.2004.12.036
   Baranek C, 2012, P NATL ACAD SCI USA, V109, P3546, DOI 10.1073/pnas.1108718109
   Bedogni F, 2010, P NATL ACAD SCI USA, V107, P13129, DOI 10.1073/pnas.1002285107
   Ben-David E, 2011, HUM MOL GENET, V20, P3632, DOI 10.1093/hmg/ddr283
   Bentivoglio M, 1999, BRAIN RES BULL, V49, P305, DOI 10.1016/S0361-9230(99)00065-9
   Bowers JM, 2012, DIS MARKERS, V33, P251, DOI 10.3233/DMA-2012-0919
   Britanova O, 2008, NEURON, V57, P378, DOI 10.1016/j.neuron.2007.12.028
   Casanova MF, 2002, NEUROLOGY, V58, P428
   Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552
   CAVINESS VS, 1982, DEV BRAIN RES, V4, P293, DOI 10.1016/0165-3806(82)90141-9
   CAVINESS VS, 1995, TRENDS NEUROSCI, V18, P379, DOI 10.1016/0166-2236(95)93933-O
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Chen B, 2008, P NATL ACAD SCI USA, V105, P11382, DOI 10.1073/pnas.0804918105
   Chen B, 2005, P NATL ACAD SCI USA, V102, P17184, DOI 10.1073/pnas.0508732102
   Chen JG, 2005, P NATL ACAD SCI USA, V102, P17792, DOI 10.1073/pnas.0509032102
   Chonchaiya Weerasak, 2009, Adv Pediatr, V56, P165, DOI 10.1016/j.yapd.2009.08.008
   Clancy B, 2007, NEUROINFORMATICS, V5, P79, DOI 10.1385/NI:5:1:1
   Colantuoni C, 2011, NATURE, V478, P519, DOI 10.1038/nature10524
   Comery TA, 1997, P NATL ACAD SCI USA, V94, P5401, DOI 10.1073/pnas.94.10.5401
   Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
   D'Arcangelo G, 1998, BIOESSAYS, V20, P235, DOI 10.1002/(SICI)1521-1878(199803)20:3<235::AID-BIES7>3.3.CO;2-4
   DECARLOS JA, 1992, J NEUROSCI, V12, P1194
   DEFELIPE J, 1992, PROG NEUROBIOL, V39, P563, DOI 10.1016/0301-0082(92)90015-7
   De la Rossa A, 2013, NAT NEUROSCI, V16, P193, DOI 10.1038/nn.3299
   Del Rio JA, 2000, CEREB CORTEX, V10, P784, DOI 10.1093/cercor/10.8.784
   de Rouvroit CL, 1998, BIOCHEM PHARMACOL, V56, P1403
   Enard W, 2002, NATURE, V418, P869, DOI 10.1038/nature01025
   Englund C, 2005, J NEUROSCI, V25, P247, DOI 10.1523/JNEUROSCI.2899-04.2005
   Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006
   Fishell G, 2008, NEURON, V57, P333, DOI [10.1016/j.neuron.2008.01.018, 10.1016/i.neuron.2008.01.018]
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Girirajan S, 2013, AM J HUM GENET, V92, P221, DOI 10.1016/j.ajhg.2012.12.016
   Glaser B, 2003, AM J MED GENET A, V116A, P66, DOI 10.1002/ajmg.a.10878
   Gray PA, 2004, SCIENCE, V306, P2255, DOI 10.1126/science.1104935
   Guillemot F, 2007, PROG NEUROBIOL, V83, P37, DOI 10.1016/j.penurobio.2007.02.009
   Hamdan FF, 2010, AM J HUM GENET, V87, P671, DOI 10.1016/j.ajhg.2010.09.017
   Han WQ, 2011, P NATL ACAD SCI USA, V108, P3041, DOI 10.1073/pnas.1016723108
   Hashimoto H, 2000, MECH DEVELOP, V97, P191, DOI 10.1016/S0925-4773(00)00418-4
   Haubensak W, 2004, P NATL ACAD SCI USA, V101, P3196, DOI 10.1073/pnas.0308600100
   Hebert JM, 2008, NAT REV NEUROSCI, V9, P678, DOI 10.1038/nrn2463
   HERRMANN K, 1994, EUR J NEUROSCI, V6, P1729, DOI 10.1111/j.1460-9568.1994.tb00565.x
   Hevner RF, 2006, NEUROSCI RES, V55, P223, DOI 10.1016/j.neures.2006.03.004
   Hevner RF, 2001, NEURON, V29, P353, DOI 10.1016/S0896-6273(01)00211-2
   Hirata T, 2004, DEV DYNAM, V230, P546, DOI 10.1002/dvdy.20068
   Hirata T, 2006, DEVELOPMENT, V133, P3993, DOI 10.1242/dev.02585
   Hoerder-Suabedissen A, 2013, P NATL ACAD SCI USA, V110, P3555, DOI 10.1073/pnas.1218510110
   Holt R, 2010, EUR J HUM GENET, V18, P1013, DOI 10.1038/ejhg.2010.69
   Huang XL, 2010, AM J MED GENET A, V152A, P2112, DOI 10.1002/ajmg.a.33497
   Hutsler JJ, 2010, BRAIN RES, V1309, P83, DOI 10.1016/j.brainres.2009.09.120
   Hutsler JJ, 2007, BIOL PSYCHIAT, V61, P449, DOI 10.1016/j.biopsych.2006.01.015
   Ingalhalikar M, 2011, NEUROIMAGE, V57, P918, DOI 10.1016/j.neuroimage.2011.05.023
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Ip BK, 2011, CEREB CORTEX, V21, P1395, DOI 10.1093/cercor/bhq219
   Irwin SA, 2000, CEREB CORTEX, V10, P1038, DOI 10.1093/cercor/10.10.1038
   Jessell TM, 2000, NAT REV GENET, V1, P20, DOI 10.1038/35049541
   Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
   Johnson MB, 2009, NEURON, V62, P494, DOI 10.1016/j.neuron.2009.03.027
   JONES EG, 1986, J NEUROSURG, V65, P135, DOI 10.3171/jns.1986.65.2.0135
   Joshi PS, 2008, NEURON, V60, P258, DOI 10.1016/j.neuron.2008.08.006
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Kalscheuer VM, 2007, HUM GENET, V121, P501, DOI 10.1007/s00439-006-0284-0
   Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
   Kelemenova S, 2010, PSYCHIAT GENET, V20, P137, DOI 10.1097/YPG.0b013e32833a1eb3
   Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99
   Kerjan G, 2007, TRENDS GENET, V23, P623, DOI 10.1016/j.tig.2007.09.003
   Konopka G, 2012, MOL PSYCHIATR, V17, P202, DOI 10.1038/mp.2011.60
   Konopka G, 2009, NATURE, V462, P213, DOI 10.1038/nature08549
   Konopka G, 2012, NEURON, V75, P601, DOI 10.1016/j.neuron.2012.05.034
   KOSTOVIC I, 1990, J COMP NEUROL, V297, P441, DOI 10.1002/cne.902970309
   KOSTOVIC I, 1980, J NEUROCYTOL, V9, P219, DOI 10.1007/BF01205159
   Kowalczyk T, 2009, CEREB CORTEX, V19, P2439, DOI 10.1093/cercor/bhn260
   Krepischi AC, 2010, EPILEPSIA, V51, P2457, DOI 10.1111/j.1528-1167.2010.02742.x
   Kumar A, 2010, CEREB CORTEX, V20, P2103, DOI 10.1093/cercor/bhp278
   Kwan KY, 2008, P NATL ACAD SCI USA, V105, P16021, DOI 10.1073/pnas.0806791105
   Kwan KY, 2012, CELL, V149, P899, DOI 10.1016/j.cell.2012.02.060
   Kwan KY, 2012, DEVELOPMENT, V139, P1535, DOI 10.1242/dev.069963
   Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
   Lai T, 2008, NEURON, V57, P232, DOI 10.1016/j.neuron.2007.12.023
   Lamb AN, 2012, HUM MUTAT, V33, P728, DOI 10.1002/humu.22037
   Lange N, 2010, AUTISM RES, V3, P350, DOI 10.1002/aur.162
   Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042
   Lefebvre V, 2007, INT J BIOCHEM CELL B, V39, P2195, DOI 10.1016/j.biocel.2007.05.019
   Leone DP, 2008, CURR OPIN NEUROBIOL, V18, P28, DOI 10.1016/j.conb.2008.05.006
   Leoyklang P, 2007, HUM MUTAT, V28, P732, DOI 10.1002/humu.20515
   Li H, 2008, AM J MED GENET B, V147B, P194, DOI 10.1002/ajmg.b.30584
   Liu JS, 2011, CURR NEUROL NEUROSCI, V11, P171, DOI 10.1007/s11910-010-0176-5
   Liu XD, 2009, EUR J HUM GENET, V17, P228, DOI 10.1038/ejhg.2008.148
   Lodato S, 2011, NEURON, V69, P763, DOI 10.1016/j.neuron.2011.01.015
   Lu HY, 2009, AM J MED GENET A, V149A, P2321, DOI 10.1002/ajmg.a.33030
   Lui JH, 2011, CELL, V146, P18, DOI 10.1016/j.cell.2011.06.030
   MacDonald JL, 2013, COMPREHENSIVE DEVELOPMENTAL NEUROSCIENCE: PATTERNING AND CELL TYPE SPECIFICATION IN THE DEVELOPING CNS AND PNS, P475, DOI 10.1016/B978-0-12-397265-1.00098-8
   Magri C, 2011, EUR J MED GENET, V54, P361, DOI 10.1016/j.ejmg.2010.12.011
   Malatesta P, 2003, NEURON, V37, P751, DOI 10.1016/S0896-6273(03)00116-8
   Mallamaci A, 2006, EUR J NEUROSCI, V23, P847, DOI 10.1111/j.1460-9568.2006.04634.x
   Manzini MC, 2011, CURR OPIN GENET DEV, V21, P333, DOI 10.1016/j.gde.2011.01.006
   Marin O, 2003, ANNU REV NEUROSCI, V26, P441, DOI 10.1146/annurev.neuro.26.041002.131058
   MARINPADILLA M, 1992, J COMP NEUROL, V321, P223, DOI 10.1002/cne.903210205
   MARINPADILLA M, 1978, ANAT EMBRYOL, V152, P109, DOI 10.1007/BF00315920
   MARINPAD.M, 1971, Z ANAT ENTWICKLUNGS, V134, P117, DOI 10.1007/BF00519296
   Markram H, 2004, NAT REV NEUROSCI, V5, P793, DOI 10.1038/nrn1519
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   McKenna WL, 2011, J NEUROSCI, V31, P549, DOI 10.1523/JNEUROSCI.4131-10.2011
   Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
   Michaelson JJ, 2012, CELL, V151, P1431, DOI 10.1016/j.cell.2012.11.019
   Miyata T, 2004, DEVELOPMENT, V131, P3133, DOI 10.1242/dev.01173
   Miyoshi G, 2007, J NEUROSCI, V27, P7786, DOI 10.1523/JNEUROSCI.1807-07.2007
   Miyoshi G, 2010, J NEUROSCI, V30, P1582, DOI 10.1523/JNEUROSCI.4515-09.2010
   Miyoshi G, 2011, CEREB CORTEX, V21, P845, DOI 10.1093/cercor/bhq155
   MOLLIVER ME, 1973, BRAIN RES, V50, P403, DOI 10.1016/0006-8993(73)90741-5
   Molyneaux BJ, 2007, NAT REV NEUROSCI, V8, P427, DOI 10.1038/nrn2151
   Molyneaux BJ, 2005, NEURON, V47, P817, DOI 10.1016/j.neuron.2005.08.030
   Monuki ES, 2001, NAT NEUROSCI, V4, P1199, DOI 10.1038/nn752
   Mountcastle VB, 1997, BRAIN, V120, P701, DOI 10.1093/brain/120.4.701
   Nadarajah B, 2002, NAT REV NEUROSCI, V3, P423, DOI 10.1038/nrn845
   Nagae LM, 2012, AM J NEURORADIOL, V33, P1720, DOI 10.3174/ajnr.A3037
   NAGAI T, 1995, AM J MED GENET, V55, P16, DOI 10.1002/ajmg.1320550106
   Nakashima N, 2010, BRAIN DEV-JPN, V32, P98, DOI 10.1016/j.braindev.2008.12.021
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   NIEUWENHUYS R, 1994, ANAT EMBRYOL, V190, P307
   Noctor SC, 2004, NAT NEUROSCI, V7, P136, DOI 10.1038/nn1172
   Noctor SC, 2008, J COMP NEUROL, V508, P28, DOI 10.1002/cne.21669
   NORTHCUTT RG, 1995, TRENDS NEUROSCI, V18, P373
   OLEARY DDM, 1993, NEURON, V10, P991, DOI 10.1016/0896-6273(93)90049-W
   Oldham MC, 2008, NAT NEUROSCI, V11, P1271, DOI 10.1038/nn.2207
   O'Leary DDM, 2008, CURR OPIN NEUROBIOL, V18, P90, DOI 10.1016/j.conb.2008.05.011
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Palumbo O, 2013, GENE, V516, P107, DOI 10.1016/j.gene.2012.12.073
   Palumbo O, 2012, MOL CYTOGENET, V5, DOI 10.1186/1755-8166-5-1
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850
   Peters A, 2010, NEUROCHEMICAL BASIS OF AUTISM: FROM MOLECULES TO MINICOLUMNS, P45, DOI 10.1007/978-1-4419-1272-5_4
   Polleux F, 2007, NAT REV NEUROSCI, V8, P331, DOI 10.1038/nrn2118
   Prasad A, 2012, G3-GENES GENOM GENET, V2, P1665, DOI 10.1534/g3.112.004689
   RAKIC P, 1974, SCIENCE, V183, P425, DOI 10.1126/science.183.4123.425
   RAKIC P, 1976, NATURE, V261, P467, DOI 10.1038/261467a0
   RAKIC P, 1988, SCIENCE, V241, P170, DOI 10.1126/science.3291116
   RAKIC P, 1995, TRENDS NEUROSCI, V18, P383, DOI 10.1016/0166-2236(95)93934-P
   RAKIC P, 1971, BRAIN RES, V33, P471, DOI 10.1016/0006-8993(71)90119-3
   Rash BG, 2006, CURR OPIN NEUROBIOL, V16, P25, DOI 10.1016/j.conb.2006.01.004
   Rauch A, 2012, LANCET, V380, P1674, DOI 10.1016/S0140-6736(12)61480-9
   Rice DS, 2001, ANNU REV NEUROSCI, V24, P1005, DOI 10.1146/annurev.neuro.24.1.1005
   Rosenfeld JA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006568
   Rosenfeld JA, 2010, GENET MED, V12, P694, DOI 10.1097/GIM.0b013e3181f0c5f3
   Rouaux C, 2013, NAT CELL BIOL, V15, P214, DOI 10.1038/ncb2660
   Rubenstein JLR, 2011, J CHILD PSYCHOL PSYC, V52, P339, DOI 10.1111/j.1469-7610.2010.02307.x
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x
   Saito T, 2011, CEREB CORTEX, V21, P588, DOI 10.1093/cercor/bhq125
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Schaaf CP, 2011, HUM MOL GENET, V20, P3366, DOI 10.1093/hmg/ddr243
   Schanze I, 2013, EUR J MED GENET, V56, P108, DOI 10.1016/j.ejmg.2012.11.001
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Serajee FJ, 2006, GENOMICS, V87, P75, DOI 10.1016/j.ygeno.2005.09.008
   Sessa A, 2010, GENE DEV, V24, P1816, DOI 10.1101/gad.575410
   Shim SB, 2012, NATURE, V486, P74, DOI 10.1038/nature11094
   Shukla DK, 2010, J AM ACAD CHILD PSY, V49, P1269, DOI 10.1016/j.jaac.2010.08.018
   Skaar DA, 2005, MOL PSYCHIATR, V10, P563, DOI 10.1038/sj.mp.4001614
   Srinivasan K, 2012, P NATL ACAD SCI USA, V109, P19071, DOI 10.1073/pnas.1216793109
   State MW, 2012, SCIENCE, V337, P1301, DOI 10.1126/science.1224989
   Strauss KA, 2006, NEW ENGL J MED, V354, P1370, DOI 10.1056/NEJMoa052773
   Stumm M, 2007, PRENATAL DIAG, V27, P475, DOI 10.1002/pd.1703
   Sultana R, 2002, GENOMICS, V80, P129, DOI 10.1006/geno.2002.6810
   Sundaram SK, 2008, CEREB CORTEX, V18, P2659, DOI 10.1093/cercor/bhn031
   Tabata H, 2009, CEREB CORTEX, V19, P2092, DOI 10.1093/cercor/bhn227
   Takatsuki S, 2010, AM J MED GENET A, V152A, P1020, DOI 10.1002/ajmg.a.33362
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Tarabykin V, 2001, DEVELOPMENT, V128, P1983
   Thornton GK, 2009, TRENDS GENET, V25, P501, DOI 10.1016/j.tig.2009.09.011
   Tissir F, 2003, NAT REV NEUROSCI, V4, P496, DOI 10.1038/nrn1113
   Traylor R. N., 2012, MOL SYNDROMOL, V3, P102
   UPPAL N, 2013, NEUROSCIENCE AUTISM, P313
   Valiente M, 2010, CURR OPIN NEUROBIOL, V20, P68, DOI 10.1016/j.conb.2009.12.003
   Van Buggenhout G, 2005, EUR J MED GENET, V48, P276, DOI 10.1016/j.ejmg.2005.05.005
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
   Weinstein M, 2011, HUM BRAIN MAPP, V32, P534, DOI 10.1002/hbm.21042
   Weiss LA, 2003, MOL PSYCHIATR, V8, P186, DOI 10.1038/sj.mp.4001241
   Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447
   Wonders CP, 2006, NAT REV NEUROSCI, V7, P687, DOI 10.1038/nrn1954
   Xu Q, 2004, J NEUROSCI, V24, P2612, DOI 10.1523/JNEUROSCI.5667-03.2004
   Yokota Y, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000794
   Zhang L., 2011, CEREB CORTEX, V22, P1510
NR 193
TC 2
Z9 3
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 167
EP 205
DI 10.1016/B978-0-12-418700-9.00006-X
PG 39
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100007
PM 24290386
ER

PT S
AU Chukoskie, L
   Townsend, J
   Westerfield, M
AF Chukoskie, Leanne
   Townsend, Jeanne
   Westerfield, Marissa
BE Konopka, G
TI Motor Skill in Autism Spectrum Disorders: A Subcortical View
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID DEVELOPMENTAL COORDINATION DISORDER; HIGH-FUNCTIONING AUTISM;
   ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
   DISORDER; PURSUIT EYE-MOVEMENT; BASAL GANGLIA; POSTURAL CONTROL;
   ASPERGER-SYNDROME; INFANTILE-AUTISM; CEREBRAL-CORTEX
AB The earliest observable symptoms of autism spectrum disorders (ASDs) involve motor behavior. There is a growing awareness of the developmental importance of impaired motor function in ASD and its association with social skill. Compromised motor function requires increased attention, leaving fewer resources available for processing environmental stimuli and learning. This knowledge suggests that the motor system which we know to be trainable-may be a gateway to improving outcomes of individuals living with ASD. In this review, we suggest a framework borrowed from machine learning to examine where, why, and how motor skills are different in individuals with ASD.
C1 [Chukoskie, Leanne; Westerfield, Marissa] Univ Calif San Diego, Inst Neural Computat, San Diego, CA 92103 USA.
   [Townsend, Jeanne] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.
RP Chukoskie, L (reprint author), Univ Calif San Diego, Inst Neural Computat, San Diego, CA 92103 USA.
EM lchukoskie@ucsd.edu
CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
   Abrams DA, 2013, P NATL ACAD SCI USA, V110, P12060, DOI 10.1073/pnas.1302982110
   Allen G, 1997, SCIENCE, V275, P1940, DOI 10.1126/science.275.5308.1940
   Allen G, 2004, BIOL PSYCHIAT, V56, P269, DOI 10.1016/j.biophsych.2004.06.005
   Ameis SH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028044
   Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI 10.1017/CBO9780511526770.002
   Association AP, 2013, DIAGN STAT MAN MENT
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   Balleine BW, 2007, J NEUROSCI, V27, P8161, DOI 10.1523/JNEUROSCI.1554-07.2007
   Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
   Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063
   Bauman ML, 1994, NEUROBIOLOGY AUTISM, P119
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Belmonte Matthew K, 2013, Front Integr Neurosci, V7, P47, DOI 10.3389/fnint.2013.00047
   Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004
   Berg P, 2012, PEDIATR PHYS THER, V24, P78, DOI 10.1097/PEP.0b013e31823e05e6
   Bhat AN, 2012, INFANT BEHAV DEV, V35, P838, DOI 10.1016/j.infbeh.2012.07.019
   Bilder D, 2013, J AUTISM DEV DISORD, V43, P1196, DOI 10.1007/s10803-012-1664-z
   BLACK JE, 1990, P NATL ACAD SCI USA, V87, P5568, DOI 10.1073/pnas.87.14.5568
   Bostan AC, 2013, TRENDS COGN SCI, V17, P241, DOI 10.1016/j.tics.2013.03.003
   Brown TT, 2012, NEUROPSYCHOL REV, V22, P313, DOI 10.1007/s11065-012-9214-1
   BUSHNELL EW, 1993, CHILD DEV, V64, P1005, DOI 10.1111/j.1467-8624.1993.tb04184.x
   Calhoun M, 2011, CLIN BIOMECH, V26, P200, DOI 10.1016/j.clinbiomech.2010.09.013
   Carper RA, 2000, BRAIN, V123, P836, DOI 10.1093/brain/123.4.836
   Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
   Chang CH, 2010, RES DEV DISABIL, V31, P1536, DOI 10.1016/j.ridd.2010.06.003
   Chang J. O., 2013, CLIN J SPOR IN PRESS
   Cherng RJ, 2009, GAIT POSTURE, V29, P204, DOI 10.1016/j.gaitpost.2008.08.003
   Chukoskie L, 2013, P NATL ACAD SCI USA, V110, P10438, DOI 10.1073/pnas.1301216110
   Chukoskie L, 2009, J NEUROPHYSIOL, V102, P3225, DOI 10.1152/jn.90692.2008
   Ciesielski K. T., 1990, 5 INT CHILD NEUR C T
   Ciesielski KT, 1997, NEUROPSYCHOLOGIA, V35, P643, DOI 10.1016/S0028-3932(96)00119-4
   CIESIELSKI KT, 1994, ACTA NEUROBIOL EXP, V54, P151
   Clark RA, 2010, GAIT POSTURE, V31, P307, DOI 10.1016/j.gaitpost.2009.11.012
   Clemson L, 2012, BRIT MED J, V345, DOI 10.1136/bmj.e4547
   Conner JM, 2003, NEURON, V38, P819, DOI 10.1016/S0896-6273(03)00288-5
   COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
   Courchesne E, 2001, NEUROLOGY, V57, P245
   COURCHESNE E, 1987, ARCH NEUROL-CHICAGO, V44, P335
   COURCHESNE E, 1994, AM J ROENTGENOL, V162, P123
   David Fabian J, 2012, Front Integr Neurosci, V6, P122, DOI 10.3389/fnint.2012.00122
   Daw ND, 2005, NAT NEUROSCI, V8, P1704, DOI 10.1038/nn1560
   Dayan E, 2011, NEURON, V72, P443, DOI 10.1016/j.neuron.2011.10.008
   DeLorey TM, 2008, BEHAV BRAIN RES, V187, P207, DOI 10.1016/j.bbr.2007.09.009
   Desmond JE, 1998, TRENDS COGN SCI, V2, P355, DOI 10.1016/S1364-6613(98)01211-X
   Desrochers TM, 2010, P NATL ACAD SCI USA, V107, P20512, DOI 10.1073/pnas.1013470107
   Deutsch JE, 2008, PHYS THER, V88, P1196, DOI 10.2522/ptj.20080062
   Dewey D, 2007, J INT NEUROPSYCH SOC, V13, P246, DOI 10.1017/S1355617707070270
   Dichter Gabriel S, 2012, Dialogues Clin Neurosci, V14, P319
   Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029
   Di Martino A, 2013, BIOL PSYCHIAT, V74, P623, DOI 10.1016/j.biopsych.2013.02.011
   Dowell LR, 2009, NEUROPSYCHOLOGY, V23, P563, DOI 10.1037/a0015640
   Doya K, 2000, CURR OPIN NEUROBIOL, V10, P732, DOI 10.1016/S0959-4388(00)00153-7
   Doya K, 1999, NEURAL NETWORKS, V12, P961, DOI 10.1016/S0893-6080(99)00046-5
   Doyon J, 2003, NEUROPSYCHOLOGIA, V41, P252, DOI 10.1016/S0028-3932(02)00158-6
   Durisko C, 2010, CORTEX, V46, P896, DOI 10.1016/j.cortex.2009.09.009
   Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   Elsabbagh M, 2009, J CHILD PSYCHOL PSYC, V50, P637, DOI 10.1111/j.1469-7610.2008.02051.x
   Esposito G, 2011, BRAIN DEV-JPN, V33, P367, DOI 10.1016/j.braindev.2010.07.006
   Estes A, 2011, AUTISM RES, V4, P212, DOI 10.1002/aur.193
   Fabbri-Destro M, 2009, EXP BRAIN RES, V192, P521, DOI 10.1007/s00221-008-1578-3
   Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9
   Fink GR, 2000, NEUROLOGY, V54, P1324
   Flanagan JE, 2012, AM J OCCUP THER, V66, P577, DOI 10.5014/ajot.2012.004192
   Fournier KA, 2010, GAIT POSTURE, V32, P6, DOI 10.1016/j.gaitpost.2010.02.007
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Fu M, 2012, NATURE, V483, P92, DOI 10.1038/nature10844
   Fuentes CT, 2009, NEUROLOGY, V73, P1532, DOI 10.1212/WNL.0b013e3181c0d48c
   FULKERSON SC, 1980, PERCEPT MOTOR SKILL, V50, P331
   GAFFNEY GR, 1987, AM J DIS CHILD, V141, P1330
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   GHAZIUDDIN M, 1994, J INTELL DISABIL RES, V38, P519
   Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x
   Gillberg C, 2010, J AUTISM DEV DISORD, V40, P352, DOI 10.1007/s10803-009-0883-4
   Glazebrook CM, 2008, J AUTISM DEV DISORD, V38, P114, DOI 10.1007/s10803-007-0369-1
   Glazebrook CM, 2006, MOTOR CONTROL, V10, P244
   Glazebrook CM, 2009, AUTISM, V13, P411, DOI 10.1177/1362361309105659
   Granacher U, 2013, SPORTS MED, V43, P627, DOI 10.1007/s40279-013-0041-1
   Graybiel Ann M., 1995, Trends in Neurosciences, V18, P60, DOI 10.1016/0166-2236(95)93871-T
   Graybiel AM, 1995, CURR OPIN NEUROBIOL, V5, P733, DOI 10.1016/0959-4388(95)80100-6
   GRAYBIEL AM, 1994, SCIENCE, V265, P1826, DOI 10.1126/science.8091209
   Green D, 2009, DEV MED CHILD NEUROL, V51, P311, DOI 10.1111/j.1469-8749.2008.03242.x
   GREENOUGH WT, 1985, BEHAV NEURAL BIOL, V44, P301, DOI 10.1016/S0163-1047(85)90310-3
   Greenspan SI, 2008, PEDIATRICS, V121, P828, DOI 10.1542/peds.2007-3833
   Greffou S, 2012, J AUTISM DEV DISORD, V42, P961, DOI 10.1007/s10803-011-1326-6
   Grissmer D, 2010, DEV PSYCHOL, V46, P1008, DOI 10.1037/a0020104
   Haas RH, 1996, J CHILD NEUROL, V11, P84
   HALLETT M, 1993, ARCH NEUROL-CHICAGO, V50, P1304
   Hallgato E, 2013, CORTEX, V49, P1073, DOI 10.1016/j.cortex.2012.01.002
   Happe F, 2012, GERONTOLOGY, V58, P70, DOI 10.1159/000329720
   Hardan AY, 2003, J CHILD NEUROL, V18, P317, DOI 10.1177/08830738030180050801
   HASHIMOTO T, 1995, J AUTISM DEV DISORD, V25, P1, DOI 10.1007/BF02178163
   Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356
   Hautzel H, 2009, NEUROIMAGE, V47, P2073, DOI 10.1016/j.neuroimage.2009.06.005
   Havermann K, 2010, J NEUROPHYSIOL, V103, P3302, DOI 10.1152/jn.00970.2009
   Hikosaka O, 2002, CURR OPIN NEUROBIOL, V12, P217, DOI 10.1016/S0959-4388(02)00307-0
   Hilton CL, 2012, AUTISM, V16, P430, DOI 10.1177/1362361311423018
   Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040
   HOUK JC, 1995, CEREB CORTEX, V5, P95, DOI 10.1093/cercor/5.2.95
   Hsu Hung-Chih, 2004, Chang Gung Med J, V27, P750
   Huang H J, 2001, Pediatr Phys Ther, V13, P133, DOI 10.1097/00001577-200110000-00005
   Huurnink A, 2013, J BIOMECH, V46, P1392, DOI 10.1016/j.jbiomech.2013.02.018
   Hwang EJ, 2013, FRONT NEURAL CIRCUIT, V7, DOI 10.3389/fncir.2013.00121
   Ilg W, 2012, NEUROLOGY, V79, P2056, DOI 10.1212/WNL.0b013e3182749e67
   Iverson JM, 2005, PSYCHOL SCI, V16, P367, DOI 10.1111/j.0956-7976.2005.01542.x
   Izawa J, 2012, AUTISM RES, V5, P124, DOI 10.1002/aur.1222
   Janicki MP, 2008, DISABIL HEALTH J, V1, P116, DOI 10.1016/j.dhjo.2008.02.004
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Jelsma J, 2013, DEV NEUROREHABIL, V16, P27, DOI 10.3109/17518423.2012.711781
   Johnson BP, 2013, NEUROSCIENCE, V243, P76, DOI 10.1016/j.neuroscience.2013.03.051
   Johnson Beth P, 2012, Front Integr Neurosci, V6, P99, DOI 10.3389/fnint.2012.00099
   Kanner L, 1943, NERV CHILD, V2, P217
   Kates WR, 1998, ANN NEUROL, V43, P782, DOI 10.1002/ana.410430613
   Kaufmann WE, 2003, J CHILD NEUROL, V18, P463, DOI 10.1177/08830738030180070501
   Kawakubo Y, 2007, CLIN NEUROPHYSIOL, V118, P1464, DOI 10.1016/j.clinph.2007.04.015
   Kellermann T, 2012, J NEUROSCI, V32, P11453, DOI 10.1523/JNEUROSCI.0678-12.2012
   Kemper TL, 1998, J NEUROPATH EXP NEUR, V57, P645, DOI 10.1097/00005072-199807000-00001
   Kleim JA, 1998, NEUROBIOL LEARN MEM, V69, P274, DOI 10.1006/nlme.1998.3827
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Klintsova AY, 2002, BRAIN RES, V937, P83, DOI 10.1016/S0006-8993(02)02492-7
   Klintsova AY, 1998, BRAIN RES, V800, P48, DOI 10.1016/S0006-8993(98)00495-8
   KOHENRAZ R, 1992, J AUTISM DEV DISORD, V22, P419, DOI 10.1007/BF01048244
   Kopp S, 2010, RES DEV DISABIL, V31, P350, DOI 10.1016/j.ridd.2009.09.017
   Kording K. P., 2006, NOVART FDN SYMP, V270, P198
   Kording K. P., 2006, NOVART FDN SYMP, V270, P232
   Körding Konrad P, 2006, Novartis Found Symp, V270, P191
   Kravitz AV, 2010, NATURE, V466, P622, DOI 10.1038/nature09159
   Kravitz AV, 2012, PHYSIOLOGY, V27, P167, DOI 10.1152/physiol.00004.2012
   Kreitzer AC, 2008, NEURON, V60, P543, DOI 10.1016/j.neuron.2008.11.005
   Kreitzer AC, 2007, NATURE, V445, P643, DOI 10.1038/nature05506
   Kuhn G, 2010, PSYCHOL SCI, V21, P1487, DOI 10.1177/0956797610383435
   Kushki A, 2011, J AUTISM DEV DISORD, V41, P1706, DOI 10.1007/s10803-011-1206-0
   LAJOIE Y, 1993, EXP BRAIN RES, V97, P139
   Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x
   Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x
   Langen M, 2007, BIOL PSYCHIAT, V62, P262, DOI 10.1016/j.biopsych.2006.09.040
   Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018
   Larson JCG, 2008, BRAIN, V131, P2894, DOI 10.1093/brain/awn226
   Larson JCG, 2008, AUTISM RES, V1, P341, DOI 10.1002/aur.54
   Laufer Y, 2008, GAIT POSTURE, V27, P347, DOI 10.1016/j.gaitpost.2007.04.013
   Le TH, 1998, J NEUROPHYSIOL, V79, P1535
   Lee KJ, 2013, J NEUROSCI, V33, P9794, DOI 10.1523/JNEUROSCI.0848-12.2013
   Levitt JG, 1999, PROG NEURO-PSYCHOPH, V23, P625, DOI 10.1016/S0278-5846(99)00021-4
   Libertus K, 2011, DEVELOPMENTAL SCI, V14, P1355, DOI 10.1111/j.1467-7687.2011.01084.x
   Libertus K, 2010, VISION RES, V50, P2750, DOI 10.1016/j.visres.2010.09.001
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   MANJIVIONA J, 1995, J AUTISM DEV DISORD, V25, P23, DOI 10.1007/BF02178165
   Mari M, 2003, PHILOS T ROY SOC B, V358, P393, DOI 10.1098/rstb.2002.1205
   Maski KP, 2011, CURR OPIN PEDIATR, V23, P609, DOI 10.1097/MOP.0b013e32834c9282
   Mayes SD, 2003, J AUTISM DEV DISORD, V33, P329, DOI 10.1023/A:1024462719081
   McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150
   McPartland JC, 2011, J AUTISM DEV DISORD, V41, P148, DOI 10.1007/s10803-010-1033-8
   Miles JH, 2000, AM J MED GENET, V91, P245, DOI 10.1002/(SICI)1096-8628(20000410)91:4<245::AID-AJMG1>3.0.CO;2-2
   Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002
   Minshew NJ, 2004, NEUROLOGY, V63, P2056
   Molloy CA, 2003, J AUTISM DEV DISORD, V33, P643, DOI 10.1023/B:JADD.0000006001.00667.4c
   Moruzzi S, 2011, J AUTISM DEV DISORD, V41, P1665, DOI 10.1007/s10803-011-1199-8
   Mosconi MW, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063709
   Mostofsky SH, 2006, J INT NEUROPSYCH SOC, V12, P314, DOI 10.1017/S1355617706060437
   Mostofsky SH, 2011, NEUROSCIENTIST, V17, P437, DOI 10.1177/1073858410392381
   Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
   Mukaetova-Ladinska EB, 2012, INT J GERIATR PSYCH, V27, P109, DOI 10.1002/gps.2711
   Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
   MURAKAMI JW, 1989, ARCH NEUROL-CHICAGO, V46, P689
   Murphy DGM, 2011, BRAIN RES, V1380, P22, DOI 10.1016/j.brainres.2010.10.042
   Nakamura K, 2006, J NEUROSCI, V26, P5360, DOI 10.1523/JNEUROSCI.4853-05.2006
   Naviaux RK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057380
   Nayate A, 2012, J AUTISM DEV DISORD, V42, P707, DOI 10.1007/s10803-011-1299-5
   Nazarali N, 2009, J AUTISM DEV DISORD, V39, P1401, DOI 10.1007/s10803-009-0756-x
   Niv Y, 2007, PSYCHOPHARMACOLOGY, V191, P507, DOI 10.1007/s00213-006-0502-4
   Nobile M, 2011, AUTISM, V15, P263, DOI 10.1177/1362361309356929
   Nowinski CV, 2005, PSYCHIAT RES, V137, P11, DOI 10.1016/j.psychres.2005.07.005
   O'Halloran CJ, 2012, J CLIN EXP NEUROPSYC, V34, P35, DOI 10.1080/13803395.2011.614599
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Ozonoff S, 2008, J AUTISM DEV DISORD, V38, P644, DOI 10.1007/s10803-007-0430-0
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Perry W, 2007, BIOL PSYCHIAT, V61, P482, DOI 10.1016/j.biopsych.2005.09.025
   Piek JP, 2004, HUM MOVEMENT SCI, V23, P475, DOI 10.1016/j.humov.2004.08.019
   Piven J, 2011, J AM GERIATR SOC, V59, P2151, DOI 10.1111/j.1532-5415.2011.03632.x
   Planinsec J, 2002, PERCEPT MOTOR SKILL, V94, P415, DOI 10.2466/PMS.94.2.415-423
   Provost Beth, 2007, Phys Occup Ther Pediatr, V27, P21, DOI 10.1300/J006v27n03_03
   Qiu AQ, 2010, J AM ACAD CHILD PSY, V49, P539, DOI 10.1016/j.jaac.2010.02.012
   Radonovich K J, 2013, Front Integr Neurosci, V7, P28, DOI 10.3389/fnint.2013.00028
   Ramstrand N, 2012, TECHNOL HEALTH CARE, V20, P531, DOI 10.3233/THC-2012-0696
   Redgrave P, 2010, NAT REV NEUROSCI, V11, P760, DOI 10.1038/nrn2915
   Reilly DS, 2008, J MOTOR BEHAV, V40, P90, DOI 10.3200/JMBR.40.2.90-102
   Rinehart NJ, 2006, J AUTISM DEV DISORD, V36, P757, DOI 10.1007/s10803-006-0118-x
   Rinehart NJ, 2006, EUR CHILD ADOLES PSY, V15, P256, DOI 10.1007/s00787-006-0530-y
   RITVO ER, 1986, AM J PSYCHIAT, V143, P862
   Rodier PM, 1996, J COMP NEUROL, V370, P247, DOI 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2
   SAITOH O, 1995, NEUROLOGY, V45, P317
   Schlosser R, 1998, J NEUROL NEUROSUR PS, V64, P492, DOI 10.1136/jnnp.64.4.492
   Schmitz C, 2003, NEUROSCI LETT, V348, P17, DOI 10.1016/S0304-3940(03)00644-X
   Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122
   Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2
   Sejnowski TJ, 2010, P NATL ACAD SCI USA, V107, P20151, DOI 10.1073/pnas.1014954107
   Shadmehr R, 2010, J NEUROSCI, V30, P10507, DOI 10.1523/JNEUROSCI.1343-10.2010
   Shadmehr R, 2008, EXP BRAIN RES, V185, P359, DOI 10.1007/s00221-008-1280-5
   Shadmehr R, 2010, CURR OPIN NEUROBIOL, V20, P726, DOI 10.1016/j.conb.2010.08.017
   Shavelle RM, 2001, J AUTISM DEV DISORD, V31, P569, DOI 10.1023/A:1013247011483
   Sherrington Catherine, 2011, N S W Public Health Bull, V22, P78, DOI 10.1071/NB10056
   Shetreat-Klein M., 2012, BRAIN DEV
   Shi LM, 2009, BRAIN BEHAV IMMUN, V23, P116, DOI 10.1016/j.bbi.2008.07.012
   Shih CH, 2010, RES DEV DISABIL, V31, P936, DOI 10.1016/j.ridd.2010.03.004
   Shmuelof L, 2011, NEURON, V72, P469, DOI 10.1016/j.neuron.2011.10.017
   Shukla DK, 2010, NEUROSCI LETT, V476, P46, DOI 10.1016/j.neulet.2010.03.080
   Stoodley CJ, 2012, NEUROIMAGE, V59, P1560, DOI 10.1016/j.neuroimage.2011.08.065
   Sutera S, 2007, J AUTISM DEV DISORD, V37, P98, DOI 10.1007/s10803-006-0340-6
   Takarae Y, 2007, PSYCHIAT RES-NEUROIM, V156, P117, DOI 10.1016/j.pseychresns.2007.03.008
   Takarae Y, 2004, BRAIN, V127, P2584, DOI 10.1093/brain/awh307
   Takarae Y, 2004, J NEUROL NEUROSUR PS, V75, P1359, DOI 10.1136/jnnp.2003.022491
   Teitelbaum O, 2004, P NATL ACAD SCI USA, V101, P11909, DOI 10.1073/pnas.0403919101
   Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982
   Todorov E, 2002, NAT NEUROSCI, V5, P1226, DOI 10.1038/nn963
   Travers BG, 2013, J AUTISM DEV DISORD, V43, P1568, DOI 10.1007/s10803-012-1702-x
   Tsai CL, 2009, CHILD CARE HLTH DEV, V35, P551, DOI 10.1111/j.1365-2214.2009.00974.x
   Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310
   van Batenburg-Eddes T, 2013, J DEV BEHAV PEDIATR, V34, P326, DOI 10.1097/DBP.0b013e3182961e80
   van Swieten LM, 2010, J EXP PSYCHOL HUMAN, V36, P493, DOI 10.1037/a0017177
   Vernazza-Martin S, 2005, J AUTISM DEV DISORD, V35, P91, DOI 10.1007/s10803-004-1037-3
   VILENSKY JA, 1981, ARCH NEUROL-CHICAGO, V38, P646
   Fehlow P, 1993, Padiatr Grenzgeb, V31, P259
   Weimer AK, 2001, J DEV BEHAV PEDIATR, V22, P92
   Weiss Michael J, 2013, Front Integr Neurosci, V7, P33, DOI 10.3389/fnint.2013.00033
   Whittingham K, 2010, RES DEV DISABIL, V31, P1346, DOI 10.1016/j.ridd.2010.07.006
   WILLIAMS RS, 1980, ARCH NEUROL-CHICAGO, V37, P749
   Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447
   Wuang YP, 2011, RES DEV DISABIL, V32, P312, DOI 10.1016/j.ridd.2010.10.002
   Xiang HD, 2003, HUM BRAIN MAPP, V18, P208, DOI 10.1002/hbm.10095
   Yin HH, 2005, EUR J NEUROSCI, V22, P505, DOI 10.1111/j.1460-9568.2005.04219.x
   Zikopoulos B, 2010, J NEUROSCI, V30, P14595, DOI 10.1523/JNEUROSCI.2257-10.2010
   ZILBOVICIUS M, 1995, NEUROLOGY, V45, pA162
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 235
TC 3
Z9 3
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 207
EP 249
DI 10.1016/B978-0-12-418700-9.00007-1
PG 43
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100008
PM 24290387
ER

PT S
AU Bill, BR
   Lowe, JK
   DyBuncio, CT
   Fogel, BL
AF Bill, Brent R.
   Lowe, Jennifer K.
   DyBuncio, Christina T.
   Fogel, Brent L.
BE Konopka, G
TI Orchestration of Neurodevelopmental Programs by RBFOX1: Implications for
   Autism Spectrum Disorder
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID GENOME-WIDE ASSOCIATION; COPY NUMBER VARIANTS; RNA-BINDING MOTIFS;
   SPLICING FACTORS; CAENORHABDITIS-ELEGANS; MENTAL-RETARDATION; CANDIDATE
   GENES; INCREASE RISK; PROTEIN; SCHIZOPHRENIA
AB Neurodevelopmental and neuropsychiatric disorders result from complex interactions between critical genetic factors and as-yet-unknown environmental components. To gain clinical insight, it is critical to develop a comprehensive understanding of these genetic components. RBFOX1, an RNA splicing factor, regulates expression of large genetic networks during early neuronal development, and haploinsufficiency causes severe neurodevelopmental phenotypes including autism spectrum disorder (ASD), intellectual disability, and epilepsy. Genomic testing in individuals and large patient cohorts has identified phenotypically similar cases possessing copy number variations in RBFOX1, implicating the gene as an important cause of neurodevelopmental disease. However, a significant proportion of the observed structural variation is inherited from phenotypically normal individuals, raising questions regarding overall pathogenicity of variation at the RBFOX1 locus. In this chapter, we discuss the molecular, cellular, and clinical evidence supporting the role of RBFOX1 in neurodevelopment and present a comprehensive model for the contribution of structural variation in RBFOX1 to ASD.
C1 [Bill, Brent R.; Lowe, Jennifer K.; DyBuncio, Christina T.] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Autism Res & Treatment, Dept Psychiat, Los Angeles, CA 90095 USA.
   [Bill, Brent R.; Lowe, Jennifer K.; DyBuncio, Christina T.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90024 USA.
   [Lowe, Jennifer K.; DyBuncio, Christina T.; Fogel, Brent L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA.
RP Fogel, BL (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA.
EM bfogel@ucla.edu
CR Amir-Zilberstein L, 2012, NEURON, V73, P279, DOI 10.1016/j.neuron.2011.11.019
   Andersen CL, 2011, INT J CANCER, V129, P1848, DOI 10.1002/ijc.25841
   Bajpai R, 2004, GENE EXPR PATTERNS, V5, P113, DOI 10.1016/j.modgep.2004.05.005
   Bass AJ, 2011, NAT GENET, V43, P964, DOI 10.1038/ng.936
   Bhalla K, 2004, J HUM GENET, V49, P308, DOI 10.1007/s10038-004-0145-4
   Bill BR, 2009, CURR OPIN GENET DEV, V19, P271, DOI 10.1016/j.gde.2009.04.004
   Chen-Plotkin AS, 2008, HUM MOL GENET, V17, P1349, DOI 10.1093/hmg/ddn023
   Damianov A, 2010, RNA, V16, P405, DOI 10.1261/rna.1838210
   Davis LK, 2012, AM J MED GENET A, V158A, P1654, DOI 10.1002/ajmg.a.35396
   Day A, 2007, GENOME BIOL, V8, DOI 10.1186/gb-2007-8-6-r112
   Day A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0008491
   Elia J, 2010, MOL PSYCHIATR, V15, P637, DOI 10.1038/mp.2009.57
   Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9
   Fogel BL, 2012, HUM MOL GENET, V21, P4171, DOI 10.1093/hmg/dds240
   Fogel BL, 2011, UNCOMMON CAUSES MOVE, P198
   Fogel BL, 2012, NEUROLOGY CLIN PRACT, P704
   Gallagher TL, 2011, DEV BIOL, V359, P251, DOI 10.1016/j.ydbio.2011.08.025
   Gehman LT, 2011, NAT GENET, V43, P706, DOI 10.1038/ng.841
   Hamshere ML, 2009, BRIT J PSYCHIAT, V195, P23, DOI 10.1192/bjp.bp.108.061424
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   HODGKIN J, 1994, DEVELOPMENT, V120, P3681
   Holsboer F, 2008, EUR J PHARMACOL, V583, P350, DOI 10.1016/j.ejphar.2007.12.032
   Hu J, 2013, P NATL ACAD SCI USA, V110, P14520, DOI 10.1073/pnas.1308610110
   Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
   Stone JL, 2008, NATURE, V455, P237, DOI 10.1038/nature07239
   Jin Y, 2003, EMBO J, V22, P905, DOI 10.1093/emboj/cdg089
   KOHANNIM O, 2012, P IEEE INT S BIOM IM, P1160
   Kuroyanagi H, 2009, CELL MOL LIFE SCI, V66, P3895, DOI 10.1007/s00018-009-0120-5
   Lal D, 2013, EPILEPSIA, V54, P265, DOI 10.1111/epi.12084
   Lee JA, 2009, GENE DEV, V23, P2284, DOI 10.1101/gad.1837009
   Lee Y, 2012, PSYCHIAT GENET, V22, P206, DOI 10.1097/YPG.0b013e328353ae3d
   Le-Niculescu H, 2009, AM J MED GENET B, V150B, P155, DOI 10.1002/ajmg.b.30887
   Lim C, 2013, SCIENCE, V340, P875, DOI 10.1126/science.1234785
   Lim J, 2006, CELL, V125, P801, DOI 10.1016/j.cell.2006.03.032
   Linnebacher M, 2013, ONCOL LETT, V5, P173, DOI 10.3892/ol.2012.1006
   Ma LJ, 2010, DIABETES, V59, P2837, DOI 10.2337/db09-1604
   Martin CL, 2007, AM J MED GENET B, V144B, P869, DOI 10.1002/ajmg.b.30530
   Mazzone L, 2012, ANN GEN PSYCHIATR, V11, DOI 10.1186/1744-859X-11-16
   Melhem N, 2011, BIOL PSYCHIAT, V70, P1115, DOI 10.1016/j.biopsych.2011.08.009
   Meyer KJ, 2012, PSYCHIAT GENET, V22, P137, DOI 10.1097/YPG.0b013e32834dc3f5
   Mikhail FM, 2011, AM J MED GENET A, V155A, P2386, DOI 10.1002/ajmg.a.34177
   Obayashi T, 2011, NUCLEIC ACIDS RES, V39, pD1016, DOI 10.1093/nar/gkq1147
   Pescosolido Matthew F, 2012, Dialogues Clin Neurosci, V14, P239
   Pistoni M, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003186
   Priebe L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064035
   Ray D, 2013, NATURE, V499, P172, DOI 10.1038/nature12311
   Richdale AL, 2009, SLEEP MED REV, V13, P403, DOI 10.1016/j.smrv.2009.02.003
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Shibata H, 2000, HUM MOL GENET, V9, P1303, DOI 10.1093/hmg/9.9.1303
   Stambolian D, 2013, HUM MOL GENET, V22, P2754, DOI 10.1093/hmg/ddt116
   Stevens SJC, 2011, AM J MED GENET A, V155A, P2739, DOI 10.1002/ajmg.a.34274
   Sun SY, 2012, RNA, V18, P274, DOI 10.1261/rna.030486.111
   Takahashi K, 2006, CELL, V126, P663, DOI 10.1016/j.cell.2006.07.024
   Underwood JG, 2005, MOL CELL BIOL, V25, P10005, DOI 10.1128/MCB.25.22.10005-10016.2005
   Usha N, 2010, DEV BIOL, V341, P389, DOI 10.1016/j.ydbio.2010.02.039
   Van Den Bossche MJ, 2013, AM J MED GENET B, V162B, P273, DOI 10.1002/ajmg.b.32146
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Vrijenhoek T, 2008, AM J HUM GENET, V83, P504, DOI 10.1016/j.ajhg.2008.09.011
   Wang ET, 2008, NATURE, V456, P470, DOI 10.1038/nature07509
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Wintle RF, 2011, AUTISM RES, V4, P89, DOI 10.1002/aur.173
   Xu B, 2008, NAT GENET, V40, P880, DOI 10.1038/ng.162
   Yeo GW, 2007, PLOS COMPUT BIOL, V3, P1951, DOI 10.1371/journal.pcbi.0030196
   Yeo GW, 2007, PLOS GENET, V3, pe85
   Yi SJ, 2005, MOL BIOL EVOL, V22, P1223, DOI 10.1093/molbev/msi106
   Zhang CL, 2008, GENE DEV, V22, P2550, DOI 10.1101/gad.1703108
   Zhao WW, 2013, MOL CYTOGENET, V6, DOI 10.1186/1755-8166-6-26
   Zhou HL, 2008, MOL CELL BIOL, V28, P5507, DOI 10.1128/MCB.00530-08
NR 68
TC 2
Z9 2
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 251
EP 267
DI 10.1016/B978-0-12-418700-9.00008-3
PG 17
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100009
PM 24290388
ER

PT S
AU Hsiao, EY
AF Hsiao, Elaine Y.
BE Konopka, G
TI Immune Dysregulation in Autism Spectrum Disorder
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID MAJOR HISTOCOMPATIBILITY COMPLEX; CONGENITAL CYTOMEGALOVIRUS-INFECTION;
   DORSOLATERAL PREFRONTAL CORTEX; LYMPHOBLASTOID CELL-LINES;
   FRAGILE-X-SYNDROME; GENE-EXPRESSION; MATERNAL AUTOANTIBODIES;
   BRAIN-DEVELOPMENT; TWIN PAIRS; MICROGLIAL ACTIVATION
AB Autism spectrum disorder (ASD) is a highly heterogeneous disorder diagnosed based on the presence and severity of core abnormalities in social communication and repetitive behavior, yet several studies converge on immune dysregulation as a feature of ASD. Widespread alterations in immune molecules and responses are seen in the brains and periphery of ASD individuals, and early life immune disruptions are associated with ASD. This chapter discusses immune-related environmental and genetic risk factors for ASD, emphasizing population-wide studies and animal research that reveal potential mechanistic pathways involved in the development of ASD-related symptoms. It further reviews immunologic pathologies seen in ASD individuals and how such abnormalities can impact neurodevelopment and behavior. Finally, it evaluates emerging evidence for an immune contribution to the pathogenesis of ASD and a potential role for immunomodulatory effects in current treatments for ASD.
C1 CALTECH, Div Chem & Chem Engn, Div Biol & Biol Engn, Pasadena, CA 91125 USA.
RP Hsiao, EY (reprint author), CALTECH, Div Chem & Chem Engn, Div Biol & Biol Engn, Pasadena, CA 91125 USA.
EM ehsiao@caltech.edu
CR Abazyan B, 2010, BIOL PSYCHIAT, V68, P1172, DOI 10.1016/j.biopsych.2010.09.022
   Abdallah MW, 2012, TURK PSIKIYATR DERG, V23, P229, DOI 10.5080/u6847
   Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
   AL-Ayadhi LY, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-158
   Arrode-Bruses G, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-83
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Ashwood P, 2008, J NEUROIMMUNOL, V204, P149, DOI 10.1016/j.jneuroim.2008.07.006
   Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
   Ashwood P, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019299
   Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
   Atladottir HO, 2012, PEDIATRICS, V130, pE1447, DOI 10.1542/peds.2012-1107
   Atladottir HO, 2009, PEDIATRICS, V124, P687, DOI 10.1542/peds.2008-2445
   Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
   Baharnoori M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054439
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Basterzi AD, 2010, PROG NEURO-PSYCHOPH, V34, P70, DOI 10.1016/j.pnpbp.2009.09.025
   Bauman M. D., 2011, 2011 NEUR M PLANN SO
   Bauman MD, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.47
   Bauman ML, 2010, NEUROTHERAPEUTICS, V7, P320, DOI 10.1016/j.nurt.2010.06.001
   Bilbo SD, 2013, HORM BEHAV, V63, P684, DOI 10.1016/j.yhbeh.2013.02.017
   Bitzer-Quintero O K, 2012, NEURAL PLAST, V2012, DOI DOI 10.1155/2012/348642
   Braunschweig D, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.50
   Braunschweig D, 2012, J NEUROIMMUNOL, V252, P56, DOI 10.1016/j.jneuroim.2012.08.002
   Braunschweig D, 2012, ARCH NEUROL-CHICAGO, V69, P693, DOI 10.1001/archneurol.2011.2506
   Braunschweig D, 2012, J AUTISM DEV DISORD, V42, P1435, DOI 10.1007/s10803-011-1378-7
   Breece E, 2013, BRAIN BEHAV IMMUN, V31, P69, DOI 10.1016/j.bbi.2012.10.006
   Brown AS, 2012, DEV NEUROBIOL, V72, P1272, DOI 10.1002/dneu.22024
   Brown AS, 2013, MOL PSYCHIAT
   Brown RS, 2009, CURR OPIN PEDIATR, V21, P523, DOI 10.1097/MOP.0b013e32832cf824
   Brynskikh A, 2008, BRAIN BEHAV IMMUN, V22, P861, DOI 10.1016/j.bbi.2007.12.008
   Campbell DB, 2009, PEDIATRICS, V123, P1018, DOI 10.1542/peds.2008-0819
   Careaga Milo, 2012, Methods Mol Biol, V934, P219, DOI 10.1007/978-1-62703-071-7_12
   Carpentier PA, 2011, AM J PATHOL, V178, P2802, DOI 10.1016/j.ajpath.2011.02.042
   Cecchelli C., 2010, CASE REPORT MED, V2010
   Chaste Pauline, 2012, Dialogues Clin Neurosci, V14, P281
   Chen ML, 2011, IMMUNOL LETT, V140, P81, DOI 10.1016/j.imlet.2011.06.011
   Chen ML, 2012, INT IMMUNOPHARMACOL, V12, P197, DOI 10.1016/j.intimp.2011.11.011
   Chen SK, 2010, CELL, V141, P775, DOI 10.1016/j.cell.2010.03.055
   CHESS S, 1971, J AUTISM CHILD SCHIZ, V1, P33, DOI 10.1007/BF01537741
   Ching H, 2012, COCHRANE DB SYST REV, V5
   Chow ML, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002592
   Comi AM, 1999, J CHILD NEUROL, V14, P388, DOI 10.1177/088307389901400608
   Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
   Corbett BA, 2007, MOL PSYCHIATR, V12, P292, DOI 10.1038/sj.mp.4001943
   Coury Daniel L, 2012, Pediatrics, V130 Suppl 2, pS160, DOI 10.1542/peds.2012-0900N
   Crespi BJ, 2011, GENES BRAIN BEHAV, V10, P689, DOI 10.1111/j.1601-183X.2011.00710.x
   Cushman J, 2003, CLIN DIAGN LAB IMMUN, V10, P13, DOI 10.1128/CDLI.10.13-18.2003
   Dalton P, 2003, ANN NEUROL, V53, P533, DOI 10.1002/ana.10557
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   de Lacy N, 2013, ANNU REV CLIN PSYCHO, V9, P555, DOI 10.1146/annurev-clinpsy-050212-185627
   Delorme R, 2013, NAT MED, V19, P685, DOI 10.1038/nm.3193
   Derecki NC, 2012, NATURE, V484, P105, DOI 10.1038/nature10907
   Deutsch SI, 2012, BRAIN RES, V1439, P96, DOI 10.1016/j.brainres.2011.12.040
   Deverman BE, 2009, NEURON, V64, P61, DOI 10.1016/j.neuron.2009.09.002
   Ehninger D, 2012, MOL PSYCHIATR, V17, P62, DOI 10.1038/mp.2010.115
   Elmer BM, 2012, TRENDS NEUROSCI, V35, P660, DOI 10.1016/j.tins.2012.08.001
   Enstrom AM, 2009, BRAIN BEHAV IMMUN, V23, P124, DOI 10.1016/j.bbi.2008.08.001
   Fidler DJ, 2000, DEV MED CHILD NEUROL, V42, P737, DOI 10.1017/S0012162200001365
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Forrest CM, 2012, MOL BRAIN, V5, DOI 10.1186/1756-6606-5-22
   Fox E, 2012, DEV NEUROBIOL, V72, P1327, DOI 10.1002/dneu.22052
   Frick LR, 2009, BRAIN BEHAV IMMUN, V23, P36, DOI 10.1016/j.bbi.2008.06.010
   Garay PA, 2012, BRAIN BEHAV IMMUN, V31, P54
   Garay Paula A, 2010, Front Synaptic Neurosci, V2, P136, DOI 10.3389/fnsyn.2010.00136
   Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012
   Garbett KA, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.24
   Ginsberg MR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044736
   Giovanoli S, 2013, SCIENCE, V339, P1095, DOI 10.1126/science.1228261
   Girard S, 2010, J IMMUNOL, V184, P3997, DOI 10.4049/jimmunol.0903349
   Glatt S. J., 2012, J AM ACAD CHILD ADOL, V51, pe932
   Goines P, 2011, BRAIN BEHAV IMMUN, V25, P514, DOI 10.1016/j.bbi.2010.11.017
   Goines PE, 2013, NEUROTOXICOL TERATOL, V36, P67, DOI 10.1016/j.ntt.2012.07.006
   Gregg JP, 2008, GENOMICS, V91, P22, DOI 10.1016/j.ygeno.2007.09.003
   Grigorenko EL, 2008, PEDIATRICS, V122, pE438, DOI 10.1542/peds.2007-3604
   Gupta S, 2010, J CLIN IMMUNOL, V30, pS90, DOI 10.1007/s10875-010-9402-9
   Hagerman R, 2012, RESULTS PROBL CELL D, V54, P297, DOI 10.1007/978-3-642-21649-7_17
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hamlyn J, 2013, NEUROBIOL DIS, V53, P3, DOI 10.1016/j.nbd.2012.10.023
   Hardan AY, 2002, J CHILD ADOL PSYCHOP, V12, P237, DOI 10.1089/104454602760386923
   Harvey L, 2012, DEV NEUROBIOL, V72, P1335, DOI 10.1002/dneu.22043
   Heo Y, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020912
   Heuer L, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.48
   Heuer L, 2008, AUTISM RES, V1, P275, DOI 10.1002/aur.42
   Heuer LS, 2012, J NEUROIMMUNOL, V251, P94, DOI 10.1016/j.jneuroim.2012.07.001
   Hohnadel E, 2007, NEUROPHARMACOLOGY, V52, P542, DOI 10.1016/j.neuropharm.2006.08.025
   Hollander E, 2012, AM J PSYCHIAT, V169, P292, DOI 10.1176/appi.ajp.2011.10050764
   Hsiao E. Y., 2012, AUTISM, pS1
   Hsiao EY, 2012, DEV NEUROBIOL, V72, P1317, DOI 10.1002/dneu.22045
   Hsiao EY, 2011, BRAIN BEHAV IMMUN, V25, P604, DOI 10.1016/j.bbi.2010.12.017
   Hsiao EY, 2012, P NATL ACAD SCI USA, V109, P12776, DOI 10.1073/pnas.1202556109
   Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775
   Hu VW, 2009, AUTISM RES, V2, P78, DOI 10.1002/aur.73
   Strange A, 2012, BIOL PSYCHIAT, V72, P620, DOI 10.1016/j.biopsych.2012.05.035
   IVARSSON SA, 1990, NEUROPEDIATRICS, V21, P102, DOI 10.1055/s-2008-1071471
   Jia PL, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002587
   Jonakait GM, 2012, DEV NEUROBIOL, V72, P857, DOI 10.1002/dneu.20969
   Kanne SM, 2011, J AUTISM DEV DISORD, V41, P926, DOI 10.1007/s10803-010-1118-4
   KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100
   Keil A, 2010, EPIDEMIOLOGY, V21, P805, DOI 10.1097/EDE.0b013e3181f26e3f
   Kim DJ, 2001, INT J NEUROSCI, V111, P11, DOI 10.3109/00207450108986549
   Kipnis J, 2004, P NATL ACAD SCI USA, V101, P8180, DOI 10.1073/pnas.0402268101
   Kohane IS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033224
   Kong SW, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049475
   Kotturi Maya F, 2009, Immunome Res, V5, P3, DOI 10.1186/1745-7580-5-3
   Lee B. K., 2012, IMFAR TOR CAN
   Li XH, 2009, J NEUROIMMUNOL, V207, P111, DOI 10.1016/j.jneuroim.2008.12.002
   Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011
   Mandal M, 2011, BRAIN BEHAV IMMUN, V25, P863, DOI 10.1016/j.bbi.2010.09.011
   Martin LA, 2008, BRAIN BEHAV IMMUN, V22, P806, DOI 10.1016/j.bbi.2007.12.007
   McCusker RH, 2013, J EXP BIOL, V216, P84, DOI 10.1242/jeb.073411
   Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
   Meyer U, 2009, NEUROSCI BIOBEHAV R, V33, P1061, DOI 10.1016/j.neubiorev.2009.05.001
   Michel M, 2012, DEV NEUROBIOL, V72, P1277, DOI 10.1002/dneu.22044
   MOMBAERTS P, 1994, INT IMMUNOL, V6, P1061, DOI 10.1093/intimm/6.7.1061
   Momeni N, 2012, AUTISM RES TREAT, V2012
   Morgan JT, 2012, BRAIN RES, V1456, P72, DOI 10.1016/j.brainres.2012.03.036
   Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
   Morris CM, 2009, PEDIATR NEUROL, V41, P288, DOI [10.1016/j.pediatrneurol.2009.04.014, 10.1016/j.pediatrneuro1.2009.04.014]
   Mostafa GA, 2013, J NEUROIMMUNOL, V255, P70, DOI 10.1016/j.jneuroim.2012.10.002
   Mostafa GA, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-71
   Napolioni V, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-38
   Needleman LA, 2012, DEV NEUROBIOL, V72, P1288, DOI 10.1002/dneu.22046
   Nicolson R, 2006, J CHILD ADOL PSYCHOP, V16, P621, DOI 10.1089/cap.2006.16.621
   Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
   Noh HJ, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003523
   Nordahl CW, 2013, BRAIN BEHAV IMMUN, V30, P61, DOI 10.1016/j.bbi.2013.01.084
   Nunez MJ, 2006, NEUROSCI LETT, V396, P247, DOI 10.1016/j.neulet.2005.11.042
   Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
   Onore CE, 2012, BIOL PSYCHIAT, V72, P1020, DOI 10.1016/j.biopsych.2012.05.004
   Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
   Patterson PH, 2012, BRAIN BEHAV IMMUN, V26, P393, DOI 10.1016/j.bbi.2011.09.008
   Pavlov VA, 2009, BRAIN BEHAV IMMUN, V23, P41, DOI 10.1016/j.bbi.2008.06.011
   Posey DJ, 2004, AM J PSYCHIAT, V161, P2115, DOI 10.1176/appi.ajp.161.11.2115
   Ramos PS, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-4
   Ratnayake U, 2012, BRAIN BEHAV IMMUN, V26, P1288, DOI 10.1016/j.bbi.2012.08.011
   Richtand NM, 2012, PHYSIOL BEHAV, V106, P171, DOI 10.1016/j.physbeh.2012.02.004
   Rogoz Z, 2009, PHARMACOL REP, V61, P1050
   Rosen NJ, 2007, PEDIATRICS, V119, pE61, DOI 10.1542/peds.2006-1788
   Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
   Ross HE, 2013, BRAIN BEHAV IMMUN, V31, P76, DOI 10.1016/j.bbi.2012.12.021
   Rotschafer SE, 2012, BRAIN RES, V1439, P7, DOI 10.1016/j.brainres.2011.12.041
   Rout UK, 2012, EUR CHILD ADOLES PSY, V21, P141, DOI 10.1007/s00787-012-0245-1
   Ruff JS, 2012, ADV EXP MED BIOL, V738, P290, DOI 10.1007/978-1-4614-1680-7_17
   Sacco R, 2012, AUTISM RES, V5, P137, DOI 10.1002/aur.1226
   Sarachana T, 2010, GENOME MED, V2, DOI 10.1186/gm144
   Saxena V, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048835
   Schneider T, 2008, PSYCHONEUROENDOCRINO, V33, P728, DOI 10.1016/j.psyneuen.2008.02.011
   Seno MMG, 2011, BRAIN RES, V1380, P85, DOI 10.1016/j.brainres.2010.09.046
   Shatz CJ, 2009, NEURON, V64, P40, DOI 10.1016/j.neuron.2009.09.044
   Singer HS, 2009, J NEUROIMMUNOL, V211, P39, DOI 10.1016/j.jneuroim.2009.03.011
   Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168
   STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
   Stephan AH, 2012, ANNU REV NEUROSCI, V35, P369, DOI 10.1146/annurev-neuro-061010-113810
   Sturm T, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2610
   Suzuki K, 2013, JAMA PSYCHIAT, V70, P49, DOI 10.1001/jamapsychiatry.2013.272
   Swedo S. E., 2010, IMFAR PHIL PA
   Sweeten TL, 2004, J AUTISM DEV DISORD, V34, P583, DOI 10.1007/s10803-004-2552-y
   Tang B, 2013, BRAIN BEHAV IMMUN, V30, P168, DOI 10.1016/j.bbi.2013.01.086
   Tetreault NA, 2012, J AUTISM DEV DISORD, V42, P2569, DOI 10.1007/s10803-012-1513-0
   Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
   Torres AR, 2012, AUTISM RES TREAT, V2012, DOI DOI 10.1155/2012/959073
   Tremblay ME, 2011, J NEUROSCI, V31, P16064, DOI 10.1523/JNEUROSCI.4158-11.2011
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Vijai J, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003220
   Vincent A, 2011, LANCET NEUROL, V10, P759, DOI 10.1016/S1474-4422(11)70096-5
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Vojdani A, 2008, J NEUROIMMUNOL, V205, P148, DOI 10.1016/j.jneuroim.2008.09.005
   Vuillermot S, 2012, J NEUROSCI, V32, P436, DOI 10.1523/JNEUROSCI.4831-11.2012
   WARREN RP, 1987, J AM ACAD CHILD PSY, V26, P333, DOI 10.1097/00004583-198705000-00008
   Wei HG, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-52
   Wong C. C., 2013, MOL PSYCHIAT
   Yamashita Y, 2003, J AUTISM DEV DISORD, V33, P455, DOI 10.1023/A:1025023131029
   Yeargin-Allsopp M, 2002, MOL PSYCHIATR, V7, pS9, DOI 10.1038/sj.mp.4001164
   Young Adam M H, 2011, Front Psychiatry, V2, P27, DOI 10.3389/fpsyt.2011.00027
   Zerbo O, 2012, J AUTISM DEV DISORD, DOI [10.1007/s10803-012-1540-x, DOI 10.1007/S10803-012-1540-X]
   Zerrate MC, 2007, J PHARMACOL EXP THER, V322, P16, DOI 10.1124/jpet.107.121483
   Zhang XY, 2004, J CLIN PSYCHIAT, V65, P940
   Ziats MN, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-10
NR 178
TC 5
Z9 6
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 269
EP 302
DI 10.1016/B978-0-12-418700-9.00009-5
PG 34
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100010
PM 24290389
ER

PT S
AU Miyauchi, S
   Voineagu, I
AF Miyauchi, Shingo
   Voineagu, Irina
BE Konopka, G
TI Autism Susceptibility Genes and the Transcriptional Landscape of the
   Human Brain
SO NEUROBIOLOGY OF AUTISM
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID COPY NUMBER VARIATION; DE-NOVO MUTATIONS; LYMPHOBLASTOID CELL-LINES;
   SPECTRUM DISORDERS; FUNCTIONAL IMPACT; EXPRESSION; GENETICS; REVEALS;
   GENOME; ASSOCIATION
AB Autism is the most severe end of a spectrum of neurodevelopmental conditions, autism spectrum disorders (ASD). ASD are genetically heterogeneous, and hundreds of genes have been implicated in the etiology of the disease. Here, we discuss the contribution of brain transcriptome studies in advancing our understanding of the genetic mechanisms of ASD and review recent work characterizing the spatial and temporal variation of the human brain transcriptome, with a focus on the relevance of these data to autism susceptibility genes.
C1 [Miyauchi, Shingo; Voineagu, Irina] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia.
RP Miyauchi, S (reprint author), Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia.
EM i.voineagu@unsw.edu.au
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Anitha A, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-12
   Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Banerjee-Basu S, 2010, DIS MODEL MECH, V3, P133, DOI 10.1242/dmm.005439
   Cantor RM, 2009, CURR PSYCHIAT REP, V11, P137
   Carayol J, 2011, BIOL PSYCHIAT, V70, P880, DOI 10.1016/j.biopsych.2011.05.020
   Chow ML, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002592
   Colantuoni C, 2011, NATURE, V478, P519, DOI 10.1038/nature10524
   Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
   Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
   Enstrom AM, 2009, BRAIN BEHAV IMMUN, V23, P124, DOI 10.1016/j.bbi.2008.08.001
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
   Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012
   Ginsberg MR, 2013, SCI REP-UK, V3, DOI 10.1038/srep01831
   Gregg JP, 2008, GENOMICS, V91, P22, DOI 10.1016/j.ygeno.2007.09.003
   Guryev V, 2008, NAT GENET, V40, P538, DOI 10.1038/ng.141
   Hawrylycz MJ, 2012, NATURE, V489, P391, DOI 10.1038/nature11405
   Henrichsen CN, 2009, NAT GENET, V41, P424, DOI 10.1038/ng.345
   Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118
   Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775
   Hu VW, 2009, AUTISM RES, V2, P78, DOI 10.1002/aur.73
   Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
   KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100
   Kim S. H., 2013, NEUROSCIENCE AUTISM, P25
   Li XH, 2012, BRAIN RES BULL, V88, P543, DOI 10.1016/j.brainresbull.2012.05.017
   Lintas C., 2010, NEUROBIOL DIS, V45, P57
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   Morrow EM, 2010, J AM ACAD CHILD PSY, V49, P1091, DOI 10.1016/j.jaac.2010.08.009
   Murdoch JD, 2013, CURR OPIN GENET DEV, V23, P310, DOI 10.1016/j.gde.2013.02.003
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
   Nord AS, 2011, EUR J HUM GENET, V19, P727, DOI 10.1038/ejhg.2011.24
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Provenzano G, 2012, DIS MARKERS, V33, P225, DOI 10.3233/DMA-2012-0917
   Purcell AE, 2001, NEUROLOGY, V57, P1618
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Skuse DH, 2012, J AM ACAD CHILD PSY, V51, P344, DOI 10.1016/j.jaac.2012.02.009
   Song RR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025603
   Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Voineagu I, 2012, NEUROBIOL DIS, V45, P69, DOI 10.1016/j.nbd.2011.07.017
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
   Wiznitzer M, 2004, J CHILD NEUROL, V19, P675
   Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
   Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
   Zhou X, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027428
   Ziats MN, 2013, J MOL NEUROSCI, V49, P589, DOI 10.1007/s12031-012-9880-8
NR 56
TC 2
Z9 2
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-418700-9
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2013
VL 113
BP 303
EP 318
DI 10.1016/B978-0-12-418700-9.00010-1
PG 16
WC Neurosciences
SC Neurosciences & Neurology
GA BJP98
UT WOS:000329549100011
PM 24290390
ER

PT J
AU Langdon, PE
   Murphy, GH
   Wilson, E
   Shepstone, L
   Fowler, D
   Heavens, D
   Malovic, A
   Russell, A
AF Langdon, Peter E.
   Murphy, Glynis H.
   Wilson, Edward
   Shepstone, Lee
   Fowler, David
   Heavens, David
   Malovic, Aida
   Russell, Alexandra
TI Asperger syndrome and anxiety disorders (PAsSA) treatment trial: a study
   protocol of a pilot, multicentre, single-blind, randomised crossover
   trial of group cognitive behavioural therapy
SO BMJ OPEN
LA English
DT Article
DE Asperger Sydrome; Anxiety disorders < PSYCHIATRY; Cognitive Behavioural
   Therapy; Randomised Control Trial; Protocol
ID AUTISM SPECTRUM DISORDERS; SOCIAL PHOBIA SCALE; PSYCHOMETRIC PROPERTIES;
   PANIC DISORDER; RATING SCALE; PRIMARY-CARE; CHILDREN; ADULTS;
   AGORAPHOBIA; HEALTH
AB Introduction A number of studies have established that children, adolescents and adults with Asperger syndrome (AS) and high functioning autism (HFA) have significant problems with anxiety. Cognitive behavioural therapy (CBT) is an effective treatment for anxiety in a variety of clinical populations. There is a growing interest in exploring the effectiveness of CBT for people with AS who have mental health problems, but currently there are no known clinical trials involving adults with AS or HFA. Studies with children who have AS have reported some success. The current study aims to examine whether modified group CBT for clinically significant anxiety in an AS population is likely to be efficacious.
   Methods and analysis This study is a randomised, single-blind crossover trial. At least 36 individuals will be recruited and randomised into a treatment arm or a waiting-list control arm. During treatment, individuals will receive 3 sessions of individual CBT, followed by 21 sessions of group CBT. Primary outcome measures focus on anxiety. Secondary outcome measures focus on everyday social and psychiatric functioning, additional measures of anxiety and fear, depression, health-related quality of life and treatment cost. Assessments will be administered at pregroup and postgroup and at follow-up by researchers who are blinded to group allocation. The trial aims to find out whether or not psychological treatments for anxiety can be adapted and used to successfully treat the anxiety experienced by people with AS. Furthermore, we aim to determine whether this intervention represents good value for money.
   Ethics and dissemination The trial received a favourable ethical opinion from a National Health Service (NHS) Research Ethics Committee. All participants provided written informed consent. Findings will be shared with all trial participants, and the general public, as well as the scientific community.
   Trial Registration ISRCTN 30265294 (DOI: 10.1186/ISRCTN30265294), UKCRN 8370.
C1 [Langdon, Peter E.; Russell, Alexandra] Univ E Anglia, Dept Psychol Sci, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England.
   [Langdon, Peter E.; Russell, Alexandra] Hertfordshire Partnership NHS Fdn Trust, Broadland Clin, Norwich, Norfolk, England.
   [Murphy, Glynis H.; Malovic, Aida] Univ Kent, Tizard Ctr, Canterbury, Kent, England.
   [Wilson, Edward; Shepstone, Lee] Univ E Anglia, Norwich Med Sch, Dept Populat Hlth & Primary Care, Norwich NR4 7TJ, Norfolk, England.
   [Fowler, David; Heavens, David] Norfolk & Suffolk NHS Fdn Trust, Norwich, Norfolk, England.
RP Langdon, PE (reprint author), Univ E Anglia, Dept Psychol Sci, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England.
EM P.Langdon@uea.ac.uk
RI Wilson, Ed/N-9341-2014
OI Wilson, Ed/0000-0002-8369-1577
FU National Institute for Health Research (NIHR) [PB-PG-1208-18024];
   National Institute for Health Research Postdoctoral Fellowship
FX This article presents independent research funded by the National
   Institute for Health Research (NIHR) Research for Patient Benefit
   programme (Grant Reference: PB-PG-1208-18024). The views expressed are
   those of the author(s) and not necessarily those of the National Health
   Service (NHS), the National Institute for Health Research or the
   Department of Health. PEL is funded by a National Institute for Health
   Research Postdoctoral Fellowship.
CR Brazier J, 2002, J HEALTH ECON, V21, P271, DOI 10.1016/S0167-6296(01)00130-8
   Brown EJ, 1997, PSYCHOL ASSESSMENT, V9, P21, DOI 10.1037/1040-3590.9.1.21
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Cardaciotto L, 2004, COGN BEHAV PRACT, V11, P75, DOI 10.1016/S1077-7229(04)80009-9
   Chalfant AM, 2007, J AUTISM DEV DISORD, V37, P1842, DOI 10.1007/s10803-006-0318-4
   Connor KM, 2000, BRIT J PSYCHIAT, V176, P379, DOI 10.1192/bjp.176.4.379
   Curtis L., 2009, UNIT COSTS HLTH SOCI
   Department of Health, 2010, FULF REW LIV
   Department of Health, 2011, NHS REF COSTS 2009 2
   Dolan P, 1997, MED CARE, V35, P1095, DOI 10.1097/00005650-199711000-00002
   Fenwick E, 2001, HEALTH ECON, V10, P779, DOI 10.1002/hec.635
   Gillott Alinda, 2007, J Intellect Disabil, V11, P359, DOI 10.1177/1744629507083585
   Gillott A, 2004, J INTELL DISABIL RES, V48, P335
   Gould RA, 1997, CLIN PSYCHOL-SCI PR, V4, P291
   Green J, 2000, J AUTISM DEV DISORD, V30, P279, DOI 10.1023/A:1005523232106
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Heavens D, 2012, PEOPLE ASPERGER SYND
   HEIMBERG RG, 1992, BEHAV THER, V23, P53, DOI 10.1016/S0005-7894(05)80308-9
   Heimberg RG, 1999, PSYCHOL MED, V29, P199, DOI 10.1017/S0033291798007879
   Jarbrink K, 2003, J AUTISM DEV DISORD, V33, P395, DOI 10.1023/A:1025058711465
   Jarbrink K, 2001, AUTISM, V5, P7, DOI 10.1177/1362361301005001002
   Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
   MARKS IM, 1979, BEHAV RES THER, V17, P263, DOI 10.1016/0005-7967(79)90041-X
   National Institute for Health and Care Excellence, 2012, AUT REC REF DIAGN MA, V142
   Ooi YP, 2008, SINGAP MED J, V49, P215
   POWER KG, 1990, BRIT J GEN PRACT, V40, P289
   POWER KG, 1990, J ANXIETY DISORD, V4, P267, DOI 10.1016/0887-6185(90)90026-6
   Power KG, 2000, CLIN PSYCHOL PSYCHOT, V7, P37, DOI 10.1002/(SICI)1099-0879(200002)7:1<37::AID-CPP224>3.0.CO;2-J
   RESCORLA LA, 1986, J AM ACAD CHILD PSY, V25, P162, DOI 10.1016/S0002-7138(09)60222-3
   Roberge P, 2008, BEHAV MODIF, V32, P333, DOI 10.1177/0145445507309025
   Rowa K, 2005, CAN J PSYCHIAT, V50, P308
   Russell E, 2005, AUST NZ J PSYCHIAT, V39, P633, DOI 10.1080/j.1440-1614.2005.01637.x
   Rutter M, 1988, DIAGNOSIS ASSESSMENT, P239
   Schleismann KD, 2011, COGN BEHAV PRACT, V18, P515, DOI 10.1016/j.cbpra.2010.08.004
   Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x
   Spek AA, 2013, RES DEV DISABIL, V34, P246, DOI 10.1016/j.ridd.2012.08.009
   SZATMARI P, 1995, J AM ACAD CHILD PSY, V34, P1662, DOI 10.1097/00004583-199512000-00017
   TANTAM D, 1988, BRIT J PSYCHIAT, V153, P783, DOI 10.1192/bjp.153.6.783
   Weiss JA, 2010, CLIN PSYCHOL PSYCHOT, V17, P438, DOI 10.1002/cpp.694
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
NR 41
TC 0
Z9 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2013
VL 3
IS 7
AR e003449
DI 10.1136/bmjopen-2013-003449
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 291CO
UT WOS:000329805500066
ER

PT J
AU Weismer, SE
AF Weismer, Susan Ellis
TI Developmental Language Disorders: Challenges and Implications of
   Cross-Group Comparisons
SO FOLIA PHONIATRICA ET LOGOPAEDICA
LA English
DT Article
DE Developmental language disorders; Cross-group comparison; Specific
   language impairment; Autism spectrum disorders
ID AUTISM SPECTRUM DISORDERS; AUTOMATED VOCAL ANALYSIS; NON-WORD
   REPETITION; STATES-OF-AMERICA; SHORT-TERM-MEMORY; CULTURAL DIFFERENCES;
   ASSOCIATION CORTEX; INFANTILE-AUTISM; ITALIAN CHILDREN; SHARED ETIOLOGY
AB Historically, specific language impairment (SLI) and language deficits associated with autism spectrum disorders (ASD) have been viewed as distinct developmental language disorders. However, over the last decade or so, a considerable amount of research has explored general similarities or specific areas of overlap between children with SLI and ASD based on language and cognitive profiles, neuroimaging findings, and genetic research. The clinical classification schemes that are used to identify the children necessarily influence the extent to which SLI and ASD are viewed as overlapping or distinct conditions. Yet, the criteria used to diagnose these two populations vary across countries and even across investigators within a given country. This necessarily impacts the findings from comparative investigations of these groups. With these challenges in mind, clinical implications of evidence for similarities and distinctions between children with SLI and ASD will be discussed with respect to differential diagnosis and treatment. (C) 2013 S. Karger AG, Basel
C1 Univ Wisconsin, Dept Commun Sci & Disorders, Waisman Ctr, Madison, WI 53705 USA.
RP Weismer, SE (reprint author), Univ Wisconsin, Dept Commun Sci & Disorders, Waisman Ctr, 1500 Highland Ave, Madison, WI 53705 USA.
EM ellisweismer@wisc.edu
FU NIH [R01DC011750]
FX Support provided by NIH grant R01DC011750.
CR Akbar M, 2013, RES AUTISM SPECT DIS, V7, P494, DOI 10.1016/j.rasd.2012.09.001
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   [Anonymous], 2005, ICD10 WHO
   BARTAK L, 1975, BRIT J PSYCHIAT, V126, P127, DOI 10.1192/bjp.126.2.127
   Bartlett CW, 2012, BIOL PSYCHIAT, V72, P692, DOI 10.1016/j.biopsych.2012.05.019
   Bishop D., 2000, SPEECH LANGUAGE IMPA, P99
   Bishop D. V. M., 2008, UNDERSTANDING DEV LA, P67
   Bishop DVM, 1997, PSYCHOLOGY
   Bishop DVM, 2010, BEHAV GENET, V40, P618, DOI 10.1007/s10519-010-9381-x
   Bishop DVM, 2004, AM J MED GENET B, V128B, P54, DOI 10.1002/ajmg.b.30039
   Bishop DVM, 2000, DEV PSYCHOPATHOL, V12, P177, DOI 10.1017/S0954579400002042
   Bishop DVM, 1996, J CHILD PSYCHOL PSYC, V37, P391, DOI 10.1111/j.1469-7610.1996.tb01420.x
   Bishop DVM, 2003, NOVART FDN SYMP, V251, P213
   Bishop DVM, 2002, J CHILD PSYCHOL PSYC, V43, P917, DOI 10.1111/1469-7610.00114
   BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
   Buxbaum JD, 2001, AM J HUM GENET, V68, P1514, DOI 10.1086/320588
   CANTWELL DP, 1989, J AUTISM DEV DISORD, V19, P19, DOI 10.1007/BF02212715
   Caselli MC, 2008, NEUROPSYCHOLOGY, V22, P27, DOI 10.1037/0894-4105.22.1.27
   Charman T, 2010, FOLIA PHONIATR LOGO, V62, P166, DOI 10.1159/000314032
   Conti-Ramsden G, 1999, INT J LANG COMM DIS, V34, P359
   Conti-Ramsden G., 1999, AUTISM, V3, P371, DOI 10.1177/1362361399003004005
   Conti-Ramsden G, 2004, J SPEECH LANG HEAR R, V47, P145, DOI 10.1044/1092-4388(2004/013)
   Conti-Ramsden G, 2006, J CHILD PSYCHOL PSYC, V47, P621, DOI 10.1111/j.1469-7610.2005.01584.x
   De Fosse L, 2004, ANN NEUROL, V56, P757, DOI 10.1002/ana.20275
   Demouy J, 2011, RES AUTISM SPECT DIS, V5, P1402, DOI 10.1016/j.rasd.2011.01.026
   Eigsti IM, 2011, RES AUTISM SPECT DIS, V5, P681, DOI 10.1016/j.rasd.2010.09.001
   Eigsti IM, 2012, CHILD NEUROPSYCHOL, V18, P600, DOI 10.1080/09297049.2011.639757
   Ellis Weismer S, HDB COMMUNI IN PRESS
   Falcaro M, 2008, GENES BRAIN BEHAV, V7, P393, DOI 10.1111/j.1601-183X.2007.00364.x
   Fisher SE, 2007, FOLIA PHONIATR LOGO, V59, P130, DOI 10.1159/000101771
   Folstein SE, 2000, AM J HUM GENET, V67, P278, DOI 10.1086/303034
   Fujiki M, 2009, HDB CHILD LANGUAGE D, P406
   Geurts HM, 2008, J AUTISM DEV DISORD, V38, P1931, DOI 10.1007/s10803-008-0587-1
   Happe F, 2011, J AM ACAD CHILD PSY, V50, P540, DOI 10.1016/j.jaac.2011.03.015
   Herbert MR, 2003, DEVELOPMENTAL SCI, V6, pF11, DOI 10.1111/1467-7687.00291
   Herbert MR, 2002, ANN NEUROL, V52, P588, DOI 10.1002/ana.10349
   Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032
   Herbert MR, 2005, BRAIN, V128, P213, DOI 10.1093/brain/awh330
   Hodge SM, 2010, J AUTISM DEV DISORD, V40, P300, DOI 10.1007/s10803-009-0872-7
   Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
   Insel T, 2013, DIRECTORS BLOG TRANS
   Jarrold C, 2002, J SPEECH LANG HEAR R, V45, P531, DOI 10.1044/1092-4388(2002/042)
   Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
   Leonard L., 2009, HDB CHILD LANGUAGE D, P308
   Leonard L. B., 2000, CHILDREN SPECIFIC LA
   Leyfer OT, 2008, AUTISM RES, V1, P284, DOI 10.1002/aur.43
   Lord C, 2003, AUTISM DIAGNOSTIC OB
   Lord C., 2004, DEV LANGUAGE DISORDE, P1
   Loucas T, 2008, J CHILD PSYCHOL PSYC, V49, P1184, DOI 10.1111/j.1469-7610.2008.01951.x
   Mandy WPL, 2012, J AM ACAD CHILD PSY, V51, P41, DOI 10.1016/j.jaac.2011.10.013
   Manolitsi M, 2011, CHILD LANG TEACH THE, V27, P39, DOI 10.1177/0265659010369991
   Marini A, 2008, NEUROPSYCHOLOGIA, V46, P2816, DOI 10.1016/j.neuropsychologia.2008.05.013
   Matson JL, 2012, RES AUTISM SPECT DIS, V6, P971, DOI 10.1016/j.rasd.2011.07.019
   McGregor KK, 2012, J AUTISM DEV DISORD, V42, P35, DOI 10.1007/s10803-011-1210-4
   Montgomery JW, 2010, AM J SPEECH-LANG PAT, V19, P78, DOI 10.1044/1058-0360(2009/09-0028)
   Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133
   Norbury CF, 2013, DEV PSYCHOL, V49, P45, DOI 10.1037/a0027446
   O'Brien EK, 2003, AM J HUM GENET, V72, P1536, DOI 10.1086/375403
   Oller DK, 2010, P NATL ACAD SCI USA, V107, P13354, DOI 10.1073/pnas.1003882107
   Pappas S, 2013, NATL I MENTAL HLTH
   Paul R, LATE TALKER IN PRESS
   Paul R, 2008, RES AUTISM SPECT DIS, V2, P110, DOI 10.1016/j.rasd.2007.04.001
   Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9
   Pickles A, 2013, J AUTISM DEV DISORD, V43, P156, DOI 10.1007/s10803-012-1556-2
   Rapin I, 2003, HDB NEUROPSYCHOLOGY, V8
   Reisinger LM, 2011, J AUTISM DEV DISORD, V41, P1694, DOI 10.1007/s10803-011-1196-y
   Rice M., 2000, SPEECH LANGUAGE IMPA, P17
   Riches NG, 2011, J COMMUN DISORD, V44, P23, DOI 10.1016/j.jcomdis.2010.06.003
   Roberts JA, 2004, APPL PSYCHOLINGUIST, V25, P429, DOI 10.1017/S0142716404001201
   Rutter M, 1994, AUTISM DIAGNOSTIC IN
   St Clair MC, 2010, BRIT J DEV PSYCHOL, V28, P109, DOI 10.1348/026151009X480158
   Tager-Flusberg H, 2003, PHILOS T ROY SOC B, V358, P303, DOI 10.1098/rstb.2002.1198
   Taylor LJ, 2012, J AUTISM DEV DISORD, V42, P2067, DOI 10.1007/s10803-012-1456-5
   Thurm A, 2007, J AUTISM DEV DISORD, V37, P1721, DOI 10.1007/s10803-006-0300-1
   Tierney CD, 2012, J DEV BEHAV PEDIATR, V33, P272, DOI 10.1097/DBP.0b013e31824ea235
   Tomblin J. B., 2011, INT J LANG COMM DIS, V46, P127, DOI [DOI 10.1111/J.1460-6984.2011.00017.X, 10.1111/j.1460-6984.2011.00017.x]
   Tomblin JB, 2003, INT J LANG COMM DIS, V38, P235, DOI 10.1080/1368282031000086363
   Verhoeven JS, 2012, CEREB CORTEX, V22, P2263, DOI 10.1093/cercor/bhr292
   Warburton P, 2000, AM J MED GENET, V96, P228, DOI 10.1002/(SICI)1096-8628(20000403)96:2<228::AID-AJMG20>3.0.CO;2-G
   Warren SF, 2010, J AUTISM DEV DISORD, V40, P555, DOI 10.1007/s10803-009-0902-5
   Weismer SE, 2011, J AUTISM DEV DISORD, V41, P1065, DOI 10.1007/s10803-010-1134-4
   Whitehouse AJO, 2007, J CHILD PSYCHOL PSYC, V48, P822, DOI 10.1111/j.1469-7610.2007.01765.x
   Whitehouse AJO, 2008, J COMMUN DISORD, V41, P319, DOI 10.1016/j.jcomdis.2008.01.002
   Williams D, 2013, J AUTISM DEV DISORD, V43, P404, DOI 10.1007/s10803-012-1579-8
   Williams D, 2008, PSYCHOL BULL, V134, P944, DOI [10.1037/a0013743, 10.1037/0013743]
   Zachor D, 2011, DEV NEUROREHABIL, V14, P215, DOI 10.3109/17518423.2011.568468
NR 87
TC 3
Z9 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7762
EI 1421-9972
J9 FOLIA PHONIATR LOGO
JI Folia Phoniatr. Logop.
PY 2013
VL 65
IS 2
BP 68
EP 77
DI 10.1159/000353896
PG 10
WC Audiology & Speech-Language Pathology; Otorhinolaryngology;
   Rehabilitation
SC Audiology & Speech-Language Pathology; Otorhinolaryngology;
   Rehabilitation
GA 295QM
UT WOS:000330130600003
ER

PT J
AU Brand, T
   Barzynski, E
   Fuhrlander, S
   Hecke, D
   Schultz-Venrath, U
AF Brand, Tanja
   Barzynski, Elke
   Fuhrlaender, Sarah
   Hecke, Dagmar
   Schultz-Venrath, Ulrich
TI Psychodynamic Versus Mentalization Based Group Psychotherapy - Mental
   Health Services Research in a Day Hospital
SO GRUPPENPSYCHOTHERAPIE UND GRUPPENDYNAMIK
LA German
DT Article
DE mentalization based group psychotherapy; psychodynamic group
   psychotherapy; manual; adherence; day clinic
ID BORDERLINE PERSONALITY-DISORDER; INPATIENT GROUP-PSYCHOTHERAPY;
   RANDOMIZED CONTROLLED-TRIAL; EMOTIONAL AWARENESS SCALE; SPECTRUM
   QUOTIENT AQ; FOLLOW-UP; TREATMENT INTEGRITY; CLINICAL-TRIAL; VERSION;
   AUTISM
AB Group psychotherapy research in a day treatment setting is confronted with a series of problems. At the same time group psychotherapy research offers great potential, based on the common outlook of clinicians and researchers, to conceptualize, to implement and to explore group psychotherapies. This will be demonstrated on a current research project, which compares mentalisation based (MGBT) and psychodynamic group psychotherapy (PDGT) in the same day hospital. Initially we shall focus on the problem of adherence to a hands-on approach in both group psychotherapies, with special reference to the differences of interventions in group sequences. After this we we will outline our concept of the study design.
RP Schultz-Venrath, U (reprint author), Univ Witten Herdecke, Kooperat Klin, Klin Psychiat Psychotherapie & Psychosomat, Evangel Krankenhaus, Ferrenbergstr 24, D-51465 Bergisch Gladbach, Germany.
EM schultzvenrath@freenet.de
CR Anthony E. J., 1957, GROUP PSYCHOTHERAPY
   Bales D., 2012, HDB MENTALIZING MENT, P197
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Bateman A, 2009, AM J PSYCHIAT, V166, P1355, DOI 10.1176/appi.ajp.2009.09040539
   Bateman A, 1999, AM J PSYCHIAT, V156, P1563
   Bateman A, 2008, AM J PSYCHIAT, V165, P631, DOI 10.1176/appi.ajp.2007.07040636
   Bateman A, 2001, AM J PSYCHIAT, V158, P36, DOI 10.1176/appi.ajp.158.1.36
   Bateman A., 2012, HDB MENTALIZING MENT, P81
   Beutler L. E., 1994, HDB PSYCHOTHERAPY BE, P229
   Blackmore C., 2009, SYSTEMATIC REV EFFIC
   Blackmore C., 2012, GROUP ANAL, V45, P46
   Bolm T, 2012, PSYCHOTHER PSYCH MED, V62, P195, DOI 10.1055/s-0032-1311580
   Burlingame G. M., 2013, BERGIN GARFIELDS HDB, P640
   Burrow T, 1928, BRIT J MED PSYCHOL, V8, P198
   Burrow T, 1926, IMAGO, V12, P211
   COWEN EL, 1978, J CONSULT CLIN PSYCH, V46, P792, DOI 10.1037//0022-006X.46.4.792
   CREED F, 1989, BRIT J PSYCHIAT, V154, P341, DOI 10.1192/bjp.154.3.341
   Dziobek I, 2006, J AUTISM DEV DISORD, V36, P623, DOI 10.1007/s10803-006-0107-0
   Eikelmann B., 1999, PSYCHIAT TAGESKLINIK
   Eikelmann B, 2010, NERVENARZT, V81, P355, DOI 10.1007/s00115-009-2898-7
   Foulkes S. H., 1975, GROUP ANAL PSYCHOTHE
   Foulkes S. H., 1955, GRUPPENANALYTISCHE P, P94
   Foulkes SH, 1964, THERAPEUTIC GROUP AN
   Franke G. H., 2002, SYMPTOM CHECKLIST LR
   Freitag CM, 2007, Z KL PSYCH PSYCHOTH, V36, P280, DOI 10.1026/1616-3443.36.4.280
   Gullestad FS, 2012, PSYCHOTHER RES, V22, P426, DOI 10.1080/10503307.2012.662608
   Gullestad FS, 2013, PSYCHOTHER RES, V23, P674, DOI 10.1080/10503307.2012.684103
   Horn W, 1983, LEISTUNGSPRUFUNGSSYS
   Horowitz L. M., 2000, INVENTAR ERFASSUNG I
   Kallert TW, 2005, PSYCHIAT PRAX, V32, P132, DOI 10.1055/s-2004-834712
   Karterud S., 2012, MANUAL MENTALISERING
   Karterud S, 2013, PSYCHOTHER RES, V23, P705, DOI 10.1080/10503307.2012.708795
   Kauff P. F., 2012, WILEY BLACKWELL HDB, P13
   Kennard D., 2000, ARBEITSBUCH GRUPPENA
   Kosters M, 2006, GROUP DYN-THEOR RES, V10, P146, DOI 10.1037/1089-2699.10.2.146
   Kosters M, 2007, GRUPPENPSYCHOTHER GR, V43, P181
   Kuchenhoff J., 1998, TEILSTATIONARE PSYCH
   LANE RD, 1990, J PERS ASSESS, V55, P124, DOI 10.1207/s15327752jpa5501&2_12
   Lorentzen S, 2013, BRIT J PSYCHIAT, V203, P280, DOI 10.1192/bjp.bp.112.113688
   Lorentzen S., 2014, GROUP ANAL PSYCHOTHE
   Lorentzen S, 2014, J PSYCHIATR MENT HLT, V21, P219, DOI 10.1111/jpm.12072
   Lorentzen S., 2011, GROUP ANAL, V45, P28
   MacKenzie KR, 1997, TIME MANAGED GROUP P
   Marshall M, 2003, COCHRANE DB SYST REV
   Mattke D., 2012, GRUPPENPSYCHOTHERAPI, P405
   Ogrodniczuk JS, 2001, HARVARD REV PSYCHIAT, V9, P105
   Perepletchikova F, 2007, J CONSULT CLIN PSYCH, V75, P829, DOI 10.1037/0022-006X.75.6.829
   Perepletchikova F, 2011, CLIN PSYCHOL-SCI PR, V18, P148
   Pines M., 2010, GRUPPENPSYCHOTHERAPI, P264
   PIPER WE, 1993, HOSP COMMUNITY PSYCH, V44, P757
   Richter D., 1999, P 3 WORKSH SOFTW VIS, P1
   Schepank H., 1995, BEEINTRACHTIGUNGS SC
   Schuklenk U, 2011, P 3 AIAA ATM SPAC EN, P1
   Schultz-Venrath U., 2013, LEHRBUCH MENTALISIER
   Schultz-Venrath U, 2008, GRUPPENPSYCHOTHER GR, V44, P135
   Schultz-Venrath U, 2013, GRUPPENPSYCHOTHER GR, V49, P277
   Schultz-Venrath U., 2010, GRUPPENPSYCHOTHERAPI, P320
   Skarderud F., 2012, HDB MENTALIZING MENT, P347, DOI [10.1176/appi.ajp.2011.11101525, DOI 10.1176/APPI.AJP.2011.11101525]
   Staun L., 2012, THESIS U PSYCHOSOMAT
   Strauss B, 2012, Z PSYCHOSOM MED PSYC, V58, P394
   Subic-Wrana C, 2001, PSYCHOTHERAPEUT, V46, P176, DOI 10.1007/s002780100157
   Taubner S, 2011, PSYCHIATRY, V74, P49, DOI 10.1521/psyc.2011.74.1.49
   Tschuschke V., 1990, GRUPPENPSYCHOTHERAPI, V26, P340
   Wittchen H. U., 1997, SKID STRUKTURIERTES
   Zeeck A, 2009, PSYCHOTHER PSYCH MED, V59, P354, DOI 10.1055/s-2008-1067542
NR 65
TC 1
Z9 1
PU VANDENHOECK & RUPRECHT
PI GOTTINGEN
PA THEATERSTRASSE 13,, D-37073 GOTTINGEN, GERMANY
SN 0017-4947
J9 GRUPPENPSYCHOTHER GR
JI Gruppenpsychother. Gruppendyn.
PY 2013
VL 49
IS 4
BP 350
EP 369
PG 20
WC Psychology, Clinical
SC Psychology
GA 292EQ
UT WOS:000329885400005
ER

PT J
AU Claudon, P
   Floquet, B
   Muguet, V
   Recouvreur, B
   Maire, S
   Dekkoumi, S
   Lawson, FB
AF Claudon, Philippe
   Floquet, Brigitte
   Muguet, Vanessa
   Recouvreur, Beatrice
   Maire, Sylvie
   Dekkoumi, Sonia
   Lawson, Festus Body
TI A METHOD FOR CLINICAL CASE STUDY IN CHILD PSYCHIATRY: ANALYSIS OF THE
   EXPRESSION OF SELF AND OF "ONE'S OWN BODY" IN THE AUTISTIC CHILD AT AGE
   7 BY WAY OF THE PRESENTATION OF 15 PERSON-DRAWINGS
SO PSYCHIATRIE DE L ENFANT
LA French
DT Article
DE Autism; Body; Person-drawings; Clinical method
ID MOTHER; BABY
AB We present a clinical case study of a severely autistic child, observed during a therapeutic workshop of body-mediation (baths and massages) over a period of 15 sessions. To carry this study out, we propose a method of clinical analysis based on a psychosomatic approach of the functioning of thought process and identity. This method makes it possible to observe and concretely evaluate the effects of a therapeutic workshop on children presenting severe developmental difficulties. The study makes reference to original, pictoral, clinical material in the form of 15 spontaneous person-drawings done during the 15 sessions. The therapeutic and clinical possibilities of this type of work are discussed.
C1 [Claudon, Philippe] Univ Lorraine, MCU HDR Psychopathol, F-54000 Nancy, France.
   [Floquet, Brigitte; Lawson, Festus Body] Ctr Psychotherap Nancy Laxou, Nancy, France.
   [Maire, Sylvie] CMPP Nancy, Nancy, France.
   [Claudon, Philippe; Dekkoumi, Sonia] Univ Lorraine, F-54000 Nancy, France.
RP Claudon, P (reprint author), Univ Lorraine, 23 Bvd Albert 1er, F-54000 Nancy, France.
EM Philippe.claudon@univ-lorraine.fr
CR Ajuriaguerra J. de, 1962, REV SUISSE PSYCHOL P, V21, P1137
   Anzieu D., 1994, PENSER MOI PEAU MOI
   Bion W. R., 1979, AUX SOURCES EXPERIEN
   Bullinger A., 1997, NEUROPSYCHIAT ENFAN, V45, P652
   Bullinger A., 1997, NEUROPSYCHIATR ENF A, V45, P11
   Bullinger A., 2000, ENFANCE, V3, P213
   Ciccone A., 2005, NEUROPSYCHIAT ENFAN, V53, P24, DOI 10.1016/j.neurenf.2005.01.002
   Ciccone A., 2005, NEUROPSYCHIATR ENF A, V53, P1, DOI 10.1016/j.neurenf.2005.01.003
   Ciccone A., 2007, BEBE TEMPS
   Ciccone A., 2001, NAISANCE VIE PSYCHIQ
   Claudon P, 2008, PSYCHIAT ENFANT, V51, P125
   Claudon Ph., 2003, NEUROPSYCHIATR ENF A, V51, P336
   Gauthier J. M., 1999, CORPS ENFANT PSYCHOT
   Gauthier J. M., 2002, OBSERVATION PSYCHOTH
   Golse B, 2006, ETRE BEBE
   Golse B., 2005, AUTISME ETAT LIEUX H
   Golse B., 1995, INFORM PSYCHIAT, V71, P18
   Haag G., 1985, NEUROPSYCHIATR ENF A, V33, P2
   HAAG G, 1985, NEUROPSYCHIAT ENFAN, V33, P107
   Haag G, 1995, PSYCHIAT ENFANT, V38, P495
   Houzel D., 2005, CONCEPT ENVELOPPE PS
   Joly F., 2008, JULIAN AJURIAGUERRA, V1
   Lebovici S., 1983, NOURRISSON MERE PSYC
   Marcelli D, 1996, PSYCHIAT ENFANT, V39, P5
   MARCELLI D, 1992, PSYCHIAT ENFANT, V35, P57
   Mellier D., 2004, CHAMP PSYCHOSOMATIQU, V30, P27
   Nadel J., 2005, NEUROPSYCHIATR ENF A, V53, P378, DOI 10.1016/j.neurenf.2005.09.021
   Neisser U., 1993, PERCEIVED SELF ECOLO, P3
   Prat R., 2007, REV FRANCAISE PSYCHO, V71, P97
   Rochat Ph., 1993, PSYCHOL FRANCAISE, V38, P41
   Sami-Ali, 1998, CORPS REELS CORPS IM
   Stern D., 1989, MONDE INTERPERSONNEL
   Wallon H., 1941, EVOLUTION PSYCHOL EN
   Wallon H., 1942, ACTE PENSEE
   Weber M., 2009, DEVENIR, V21, P61
   Winnicott D. W., 1989, TRAITEMENT PSYCHANAL
   Winnicott D. W., 1975, JEU REALITE ESPACE P
   Winnicott D. W., 1976, PEDIAT PSYCHANALYSE
   Wolfs J., 2007, DEVENIR, V19, P47
NR 39
TC 0
Z9 0
PU PRESSES UNIV FRANCE
PI PARIS CEDEX 14
PA 6 AVENUE REILLE, 75685 PARIS CEDEX 14, FRANCE
SN 0079-726X
J9 PSYCHIAT ENFANT
JI Psychiatr. Enfant
PY 2013
VL 56
IS 2
BP 603
EP 638
PG 36
WC Psychiatry
SC Psychiatry
GA 292IB
UT WOS:000329894300013
ER

PT J
AU Figueroa, AM
   Juarez-Ramirez, R
AF Mejia Figueroa, Andres
   Juarez-Ramirez, Reyes
TI Teaching Human-Computer Interaction through developing Applications in
   Collaboration between Academy and Autism Organizations
SO INTERNATIONAL JOURNAL OF ENGINEERING EDUCATION
LA English
DT Article
DE collaboration between academia and autism organizations; user-centered
   design; teaching Human-Computer Interaction
AB Human-Computer Interaction is a discipline that is getting more interest nowadays, not only because the proliferation of computer science but also due the proliferation of new technological devices that require user-friendly interfaces. Furthermore, new technology is enabling us to attend needs of special groups with specific impairments, such as autistic users. Most efforts have been made in order to integrate curricula for this discipline; also most efforts have been made in the teaching context of these themes. However, it is necessary to continue improving teaching practices, integrating research and good practices from real environments. In this paper we present some experiences in teaching Human-Computer Interaction and Usability Engineering in conjunction with Software Development. Our teaching experiences involve real projects in collaboration with a specialized organization in autism. This teaching environment allows students to interact with end users, making sense of how useful is applying user interface design principles in order to facilitate the life of users with special capabilities.
C1 [Mejia Figueroa, Andres; Juarez-Ramirez, Reyes] Autonomous Univ Baja Calif, Ensenada 22390, Baja California, Mexico.
RP Figueroa, AM (reprint author), Autonomous Univ Baja Calif, Calzada Univ 14418,Parque Ind Int Tijuana, Ensenada 22390, Baja California, Mexico.
EM mejia.andres@uabc.edu.mx; reyesjua@uabc.edu.mx
CR Aberg J, 2010, ITICSE 2010: PROCEEDINGS OF THE 2010 ACM SIGCSE ANNUAL CONFERENCE ON INNOVATION AND TECHNOLOGY IN COMPUTER SCIENCE EDUCATION, P3
   Fischer G, 2001, USER MODEL USER-ADAP, V11, P65, DOI 10.1023/A:1011145532042
   Greenberg S., 1996, INTERACTIONS, V3, P62, DOI 10.1145/234813.234820
   Inzunza S., 2011, P 2011 INT C UNC REA, V1, P107
   McCrickard D. S., 2004, ACM SIGCSE B, V36, P31, DOI 10.1145/1028174.971314
   Mejia A., 2012, P CUBE INT INF TECHN, P598
   Nielsen J., 1993, USABILITY ENG, P115
   Plimmer B., 2006, ACM SIGCSE B, V38, P53, DOI 10.1145/1140123.1140141
   Ramsden P, 2003, LEARNING TEACH HIGHE
   Thimbleby H, 2009, LECT NOTES COMPUT SC, V5614, P625, DOI 10.1007/978-3-642-02707-9_71
   Winograd T., 1990, CHI 90 P SIGCHI C HU, P443
NR 11
TC 0
Z9 0
PU TEMPUS PUBLICATIONS
PI DURRUS, BANTRY
PA IJEE , ROSSMORE,, DURRUS, BANTRY, COUNTY CORK 00000, IRELAND
SN 0949-149X
J9 INT J ENG EDUC
JI Int. J. Eng. Educ
PY 2013
VL 29
IS 3
SI SI
BP 666
EP 673
PG 8
WC Education, Scientific Disciplines; Engineering, Multidisciplinary
SC Education & Educational Research; Engineering
GA 291ER
UT WOS:000329811000014
ER

PT J
AU Salem, AM
   Ismail, S
   Zarouk, WA
   Baky, OA
   Sayed, AA
   Abd El-Hamid, S
   Salem, S
AF Salem, Ahmed M.
   Ismail, Samira
   Zarouk, Waheba A.
   Baky, Olwya Abdul
   Sayed, Ahmed A.
   Abd El-Hamid, Sawsan
   Salem, Sohair
TI Genetic Variants of Neurotransmitter-Related Genes and miRNAs in
   Egyptian Autistic Patients
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID DOPAMINE-D-2 RECEPTOR POLYMORPHISM; MONOAMINE-OXIDASE-A; FUNCTIONAL
   POLYMORPHISM; THERAPEUTIC RESPONSE; SPECTRUM DISORDERS; INTRON 13; B
   GENE; ASSOCIATION; MAOA; CHILDREN
AB Autism is a neurodevelopmental disorder with indisputable evidence for a genetic component. This work studied the association of autism with genetic variations in neurotransmitter-related genes, including MAOA uVNTR, MAOB rs1799836, and DRD2 TaqI A in 53 autistic patients and 30 healthy individuals. The study also analyzed sequence variations of miR-431 and miR-21. MAOA uVNTR was genotyped by PCR, MAOB and DRD2 polymorphisms were analyzed by PCR-based RFLP, and miR-431 and miR-21 were sequenced. Low expressing allele of MAOA uVNTR was frequently higher in female patients compared to that in controls (OR = 2.25). MAOB G allele frequency was more significantly increased in autistic patients than in controls (P < 0.001 for both males and females). DRD2 A1+ genotype increased autism risk (OR = 5.1). Severity of autism tends to be slightly affected by MAOA/B genotype. Plasma MAOB activity was significantly reduced in G than in A allele carrying males. There was no significant difference in patients and maternal plasma MAOA/B activity compared to controls. Neither mutations nor SNPs in miR-431 and miR-21 were found among studied patients. This study threw light on some neurotransmitter-related genes suggesting their potential role in Autism pathogenesis that warrants further studies and much consideration.
C1 [Salem, Ahmed M.; Sayed, Ahmed A.] Ain Shams Univ, Dept Biochem, Cairo, Egypt.
   [Ismail, Samira] Natl Res Ctr, Dept Clin Genet, Giza, Egypt.
   [Zarouk, Waheba A.; Abd El-Hamid, Sawsan; Salem, Sohair] Natl Res Ctr, Dept Mol Genet, Giza, Egypt.
   [Baky, Olwya Abdul] Ain Shams Univ, Dept Child Psychiat, Cairo, Egypt.
RP Salem, S (reprint author), Natl Res Ctr, Dept Mol Genet, Giza, Egypt.
EM ssalem_nrc@hotmail.com
CR Abu-Elneel K, 2008, NEUROGENETICS, V9, P153, DOI 10.1007/s10048-008-0133-5
   Alia-Klein N, 2008, J NEUROSCI, V28, P5099, DOI 10.1523/JNEUROSCI.0925-08.2008
   Al-Salehi SM, 2009, TRANSCULT PSYCHIATRY, V46, P340, DOI 10.1177/1363461509105823
   Ambros V, 2004, NATURE, V431, P350, DOI 10.1038/nature02871
   Balciuniene J, 2002, HUM GENET, V110, P1
   Bolte S, 2007, J AUTISM DEV DISORD, V37, P243, DOI 10.1007/s10803-006-0165-3
   Bortolato M, 2013, INT J NEUROPSYCHOPH, V16, P869, DOI 10.1017/S1461145712000715
   Bortolato M, 2011, INT REV NEUROBIOL, V100, P13, DOI 10.1016/B978-0-12-386467-3.00002-9
   Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
   Cohen IL, 2011, CLIN GENET, V79, P355, DOI 10.1111/j.1399-0004.2010.01471.x
   Cohen IL, 2003, CLIN GENET, V64, P190, DOI 10.1034/j.1399-0004.2003.00115.x
   Datta A. K., 2009, CASES J, V2
   Davis LK, 2008, AM J MED GENET B, V147B, P1145, DOI 10.1002/ajmg.b.30738
   DeFrancesco L, 2001, SCIENTIST, V15, P16
   Dlugos AM, 2009, J NEURAL TRANSM, V116, P1323, DOI 10.1007/s00702-009-0281-2
   El Sawy M. A., 2011, INT J PSYCHOL COUNSE, V3, P130
   Essa M. M., 2011, INT J BIOL MED RES, V2, P811
   Filic V, 2005, J NEUROL SCI, V228, P149, DOI 10.1016/j.jns.2004.11.045
   Floresco SB, 2006, NEUROPSYCHOPHARMACOL, V31, P297, DOI 10.1038/sj.npp.1300825
   Fowler JS, 2007, BIOL PSYCHIAT, V62, P355, DOI 10.1016/j.biopsych.2006.08.038
   Garpenstrand H, 2000, J NEURAL TRANSM, V107, P523, DOI 10.1007/s007020070075
   Gasso P, 2008, NEUROPSYCHOBIOLOGY, V58, P65, DOI 10.1159/000159774
   Hettinger J. A., 2012, BEHAV BRAIN FUNCTION, V8
   KURTH JH, 1993, ANN NEUROL, V33, P368, DOI 10.1002/ana.410330406
   Lauritsen MB, 2001, ACTA PSYCHIAT SCAND, V103, P411, DOI 10.1034/j.1600-0447.2001.00086.x
   Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
   Pivac N, 2006, LIFE SCI, V79, P45, DOI 10.1016/j.lfs.2005.12.030
   Rodriguez-Revenga L, 2007, AM J MED GENET A, V143A, P916, DOI 10.1002/ajmg.a.31521
   Sabol SZ, 1998, HUM GENET, V103, P273, DOI 10.1007/s004390050816
   Saltik S, 2012, NOBEL MED, V8, P113
   Sambrook J, 2001, MOL CLONING, V3
   Sarachana T, 2010, GENOME MED, V2
   Sasanfar R., 2010, MOL AUTISM, V1
   Schmidt LG, 2000, J NEURAL TRANSM, V107, P681, DOI 10.1007/s007020070069
   Suzuki A, 2000, PHARMACOGENETICS, V10, P335, DOI 10.1097/00008571-200006000-00007
   Suzuki A, 2001, EUR ARCH PSY CLIN N, V251, P57, DOI 10.1007/s004060170053
   Tassone F, 2011, AUTISM RES, V4, P250, DOI 10.1002/aur.196
   Troost PW, 2005, J AM ACAD CHILD PSY, V44, P1137, DOI 10.1097/01.chi.0000177055.11229.76
   Wang TJ, 2007, PROG NEURO-PSYCHOPH, V31, P108, DOI 10.1016/j.pnpbp.2006.08.010
   Wei Y.-L., 2011, BEHAV BRAIN FUNCTION, V7
   Wu RM, 2001, NEUROLOGY, V56, P375
   Zhang JP, 2010, AM J PSYCHIAT, V167, P763, DOI 10.1176/appi.ajp.2009.09040598
   Zhu Z, 2009, ACTA BIOCH BIOPH SIN, V41, P407, DOI 10.1093/abbs/gmp023
NR 43
TC 0
Z9 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 670621
DI 10.1155/2013/670621
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 289PH
UT WOS:000329693900001
ER

PT J
AU Bennett, SM
   Keller, AE
   Walkup, JT
AF Bennett, Shannon M.
   Keller, Alex E.
   Walkup, John T.
BE Walkup, JT
   Shaffer, D
   Lee, FS
TI The future of tic disorder treatment
SO CHILDHOOD ONSET DEVELOPMENTAL DISORDERS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 92nd Annual Conference of the
   Association-for-Research-in-Nervous-and-Mental-Disease (ARNMD) on
   Childhood Onset Developmental Disorders
CY DEC, 2012
CL New York, NY
SP Assoc Res Nervous & Mental Dis
DE Tourette syndrome; behavior therapy; tic disorders; psychopharmacology
ID AUTISM SPECTRUM DISORDERS; INTENSIVE BEHAVIORAL TREATMENT; RANDOMIZED
   CONTROLLED-TRIAL; YOUNG-CHILDREN; RESEARCH UNITS; DENVER MODEL;
   INTERVENTIONS; RISPERIDONE; PREDICTORS; DISABILITY
AB Competing theories on the etiology and treatment of chronic tic disorders and Tourette syndrome have long made the search for efficacious intervention more challenging for patients and families seeking to reduce functional impairment related to tic symptoms. These symptoms were historically posited to be either psychological in origin, leading to the long tradition of psychoanalytic psychotherapy for tics, or biological in nature, particularly since the advent of successful treatments using neuroleptic medications. Current thinking about the phenomenology of tic disorders comes from growing empirical evidence as well as advances in neuroscience and genetics research and reveals a biological vulnerability that is exacerbated by physiological arousal related to environmental or interpersonal stress. This manuscript summarizes the evolution of this knowledge base and describes current best-practice recommendations for patients, families, and clinicians.
C1 Weill Cornell Med Coll, Div Child & Adolescent Psychiat, New York, NY USA.
   New York Presbyterian Hosp, New York, NY USA.
RP Walkup, JT (reprint author), 525 E 68th St,Rm F-1109, New York, NY 10065 USA.
EM Jtw9001@med.cornell.edu
CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
   Anderson D., J CHILD PSY IN PRESS
   Anderson DK, 2009, J ABNORM CHILD PSYCH, V37, P1019, DOI 10.1007/s10802-009-9326-0
   Anderson DK, 2007, J CONSULT CLIN PSYCH, V75, P594, DOI 10.1037/0022-006X.75.4.594
   Anderson DK, 2011, AJIDD-AM J INTELLECT, V116, P381, DOI 10.1352/1944-7558-116.5.381
   Arnold LE, 2010, J CHILD ADOL PSYCHOP, V20, P83, DOI 10.1089/cap.2009.0022
   Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
   Cohen H, 2006, J DEV BEHAV PEDIATR, V27, pS145, DOI 10.1097/00004703-200604002-00013
   Coolican J, 2010, J CHILD PSYCHOL PSYC, V51, P1321, DOI 10.1111/j.1469-7610.2010.02326.x
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Dichter GS, 2012, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095
   Frankel F, 2010, J AUTISM DEV DISORD, V40, P827, DOI 10.1007/s10803-009-0932-z
   Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237
   Gotham K, 2012, PEDIATRICS, V130, pE1278, DOI 10.1542/peds.2011-3668
   Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
   Hayward D, 2009, AUTISM, V13, P613, DOI 10.1177/1362361309340029
   Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
   Jahromi LB, 2009, J AUTISM DEV DISORD, V39, P395, DOI 10.1007/s10803-008-0636-9
   Kasari C, 2012, J AM ACAD CHILD PSY, V51, P487, DOI 10.1016/j.jaac.2012.02.019
   Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
   Lampi KM, 2012, J PEDIATR-US, V161, P830, DOI 10.1016/j.jpeds.2012.04.058
   Landa Rebecca J, 2012, Pediatrics, V130 Suppl 2, pS186, DOI 10.1542/peds.2012-0900Q
   LORD C, 1986, J AUTISM DEV DISORD, V16, P249, DOI 10.1007/BF01531658
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   McDougle CJ, 2000, CHILD ADOL PSYCH CL, V9, P201
   McGovern CW, 2005, J CHILD PSYCHOL PSYC, V46, P401, DOI 10.1111/j.1469-7610.2004.00361.x
   Mefford HC, 2012, NEW ENGL J MED, V366, P733, DOI 10.1056/NEJMra1114194
   Oosterling I, 2010, J AUTISM DEV DISORD, V40, P1447, DOI 10.1007/s10803-010-1004-0
   Rogers SJ, 2006, J AUTISM DEV DISORD, V36, P1007, DOI 10.1007/s10803-006-0142-x
   Rogers SJ, 2012, J AM ACAD CHILD PSY, V51, P1052, DOI 10.1016/j.jaac.2012.08.003
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   Scahill L, 2013, J AUTISM DEV DISORD, V43, P739, DOI 10.1007/s10803-012-1689-3
   Schreibman L., 2007, SCI FICTION AUTISM
   STAHMER AC, 1995, J AUTISM DEV DISORD, V25, P123, DOI 10.1007/BF02178500
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   State MW, 2012, SCIENCE, V337, P1301, DOI 10.1126/science.1224989
   Vernon TW, 2012, J AUTISM DEV DISORD, V42, P2702, DOI 10.1007/s10803-012-1535-7
   Volden J, 2007, J AUTISM DEV DISORD, V37, P1139, DOI 10.1007/s10803-006-0256-1
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Zarembo A., 2011, LOS ANGELES TIMES
NR 40
TC 2
Z9 2
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2013
VL 1304
BP 32
EP 39
DI 10.1111/nyas.12296
PG 8
WC Clinical Neurology; Pediatrics; Psychology
SC Neurosciences & Neurology; Pediatrics; Psychology
GA BJQ16
UT WOS:000329608800005
PM 24175754
ER

PT J
AU Purzycki, BG
   Sosis, R
AF Purzycki, Benjamin G.
   Sosis, Richard
TI The extended religious phenotype and the adaptive coupling of ritual and
   belief
SO ISRAEL JOURNAL OF ECOLOGY & EVOLUTION
LA English
DT Article
DE cognition; extended phenotype; niche construction; religion; ritual
ID SIGNALING THEORY; NICHE CONSTRUCTION; GOD CONCEPTS; MALE DISPLAY;
   EVOLUTION; COOPERATION; AUTISM; MIND; ANTHROPOLOGY; HYPOTHESIS
AB In this paper, we consider the idea that religion is a transsomatic adaptation. At the genic level, the religious system constitutes an extended phenotype that has been fashioned by natural selection to overcome socioecological challenges inherent in human sociality, primarily problems of cooperation and coordination. At the collective level, the religious system constitutes a cognitive niche. We begin our discussion focusing on the former and concentrate our attention on the "sacred coupling" of supernatural agency and ritual behavior. We detail the complex connections between genes, cognitive faculties, and their expression in religious contexts, followed by a discussion of how religious ritual functions to maintain relative social order. We conclude with a discussion about the relevance of niche construction theory for understanding the adaptive nature of religious systems.
C1 [Purzycki, Benjamin G.] Univ British Columbia, Ctr Human Evolut Cognit & Culture, Vancouver, BC V6T 1Z2, Canada.
   [Sosis, Richard] Univ Connecticut, Dept Anthropol, Storrs, CT 06269 USA.
RP Purzycki, BG (reprint author), Univ British Columbia, Ctr Human Evolut Cognit & Culture, 1871 West Mall, Vancouver, BC V6T 1Z2, Canada.
EM bgpurzycki@alumni.ubc.ca
FU SSHRC; CTI Fellowship; ESRC Large Grant [REF RES-060-25-0085]
FX Purzycki thanks the SSHRC-funded Cultural Evolution of Religion Research
   Consortium (CERC) for support during the preparation of this work. Sosis
   thanks and acknowledges support from a CTI Fellowship (Evolution and
   Human Nature) and an ESRC Large Grant (REF RES-060-25-0085) entitled
   "Ritual, Community, and Conflict." The authors thank Leon Loveridge,
   John Shaver, and the reviewers for their helpful comments on an earlier
   draft of this paper.
CR Alcorta CS, 2005, HUM NATURE-INT BIOS, V16, P323, DOI 10.1007/s12110-005-1014-3
   Atkinson QD, 2011, EVOL HUM BEHAV, V32, P50, DOI 10.1016/j.evolhumbehav.2010.09.002
   Atran S, 1998, BEHAV BRAIN SCI, V21, P547
   Atran Scott, 2002, GODS WE TRUST EVOLUT
   Axelrod R., 1984, EVOLUTION COOPERATIO
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Barrett J. L., 2012, BORN BELIEVERS SCI C
   Barrett J. L., 2008, J COGNITION CULTURE, V8, P149, DOI DOI 10.1163/156770908X289251
   Barrett JL, 1996, COGNITIVE PSYCHOL, V31, P219, DOI 10.1006/cogp.1996.0017
   Barrett Justin L., 2004, WHY WOULD ANYONE BEL
   Bering J. M., 2005, J COGNITION CULTURE, V1, P118, DOI 10.1163/1568537054068679
   Bering J. M., 2011, BELIEF INSTINCT PSYC
   BINFORD LR, 1962, AM ANTIQUITY, V28, P217, DOI 10.2307/278380
   Bird RB, 2005, CURR ANTHROPOL, V46, P221
   Blume M., 2010, NATURE GOD EVOLUTION, P159
   Blume M, 2009, FRONT COLLECT, P117, DOI 10.1007/978-3-642-00128-4_8
   BORGIA G, 1995, EMU, V95, P1
   BORGIA G, 1995, ANIM BEHAV, V49, P1291, DOI 10.1006/anbe.1995.0161
   Bouchard TJ, 2004, CURR DIR PSYCHOL SCI, V13, P148, DOI 10.1111/j.0963-7214.2004.00295.x
   Bouchard TJ, 2003, J NEUROBIOL, V54, P4, DOI 10.1002/neu.10160
   Boyer Pascal, 2002, CURRENT APPROACHES C, P68
   Boyer Pascal, 2001, RELIG EXPLAINED EVOL
   Brown D. E., 1991, HUMAN UNIVERSALS
   Bulbulia J, 2011, RELIGION, V41, P363, DOI 10.1080/0048721X.2011.604508
   Bulbulia J, 2012, BIOL PHILOS, V27, P1, DOI 10.1007/s10539-011-9295-x
   Bulbulia J, 2008, METH THEORY STUD REL, V20, P67, DOI 10.1163/157006808X260241
   Bulbulia J., 2008, EVOLUTION RELIG STUD
   Cosmides L., 2000, HDB EMOTIONS, P91
   Cronk L, 2005, SOC SCI INFORM, V44, P603, DOI 10.1177/0539018405058203
   CRONK L, 1994, ZYGON, V29, P81, DOI 10.1111/j.1467-9744.1994.tb00651.x
   Dawkins R., 1982, EXTENDED PHENOTYPE L
   DAWKINS R, 1979, PROC R SOC SER B-BIO, V205, P489, DOI 10.1098/rspb.1979.0081
   Dawkins R, 2004, BIOL PHILOS, V19, P377, DOI 10.1023/B:BIPH.0000036180.14904.96
   Dawkins Richard, 2006, GOD DELUSION
   DIAMOND J, 1987, ETHOLOGY, V74, P177
   Durkheim E., 1915, ELEMENTARY FORMS REL
   El-Fishawy P, 2010, PSYCHIAT CLIN N AM, V33, P83, DOI 10.1016/j.psc.2009.12.002
   Feierman JR, 2009, FRONT COLLECT, P51, DOI 10.1007/978-3-642-00128-4_4
   Fincher CL, 2012, BEHAV BRAIN SCI, V35, P61, DOI 10.1017/S0140525X11000021
   Frejka T, 2008, EUR J POPUL, V24, P5, DOI 10.1007/s10680-007-9121-y
   Gallagher HL, 2003, TRENDS COGN SCI, V7, P77, DOI 10.1016/S1364-6613(02)00025-6
   Gathercole Susan, 1997, COGNITIVE MODELS MEM, P13
   Geertz C., 1973, INTERPRETATION CULTU
   Guthrie Stewart, 1995, FACES CLOUDS NEW THE
   GUTHRIE S, 1980, CURR ANTHROPOL, V21, P181, DOI 10.1086/202429
   Hauser M.D., 1996, EVOLUTION COMMUNICAT
   Hunter P, 2009, EMBO REP, V10, P212, DOI 10.1038/embor.2009.18
   IANNACCONE LR, 1995, J SCI STUD RELIG, V34, P76, DOI 10.2307/1386524
   IANNACCONE LR, 1992, J POLIT ECON, V100, P271, DOI 10.1086/261818
   Jablonka E, 2004, BIOL PHILOS, V19, P353, DOI 10.1023/B:BIPH.0000036112.02199.7b
   Johnson DDP, 2005, HUM NATURE-INT BIOS, V16, P410, DOI 10.1007/s12110-005-1017-0
   Jordan Peter, 2003, MAT CULTURE SACRED L
   Kantner J, 2012, J ANTHROPOL ARCHAEOL, V31, P66, DOI 10.1016/j.jaa.2011.10.003
   Kapogiannis D, 2009, PLOS ONE, V4
   Kaufmann E., 2010, SHALL RELIG INHERIT
   Koenig L. B., 2006, GOD SCI MEET BRAIN E, V1, P31
   Kydd D., 2008, EVOLUTION RELIG STUD, P93
   Lahti DC, 2009, FRONT COLLECT, P67, DOI 10.1007/978-3-642-00128-4_5
   Laland KN, 2000, BEHAV BRAIN SCI, V23, P131, DOI 10.1017/S0140525X00002417
   Laland KN, 2004, BIOL PHILOS, V19, P313, DOI 10.1023/B:BIPH.0000036113.38737.d8
   LOFFREDO C A, 1986, American Naturalist, V128, P773, DOI 10.1086/284605
   Malley B., 1995, METHOD THEORY STUDY, V7, P5, DOI 10.1163/157006895X00180
   Malley BE, 1997, METHOD THEORY STUDY, V9, P389, DOI 10.1163/157006897X00359
   Moran JM, 2011, P NATL ACAD SCI USA, V108, P2688, DOI 10.1073/pnas.1011734108
   Norenzayan A, 2008, SCIENCE, V322, P58, DOI 10.1126/science.1158757
   Norenzayan A., 2012, PLOS ONE, V7
   Odling-Smee FJ, 1996, BEHAV PROCESS, V35, P195
   Otte D., 1974, Annual Rev Ecol Syst, V5, P385, DOI 10.1146/annurev.es.05.110174.002125
   Peoples HC, 2012, HUM NATURE-INT BIOS, V23, P253, DOI 10.1007/s12110-012-9148-6
   Pinker S., 2012, EDGE
   Pinker S., 2002, BLANK SLATE MODERN D
   PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
   Purzycki B. G., 2011, RELIG BRAIN BEHAV, V1, P31
   Purzycki BG, 2009, FRONT COLLECT, P243, DOI 10.1007/978-3-642-00128-4_17
   Purzycki BG, 2010, NATURE GOD EVOLUTION, P37
   Purzycki BG, 2012, THESIS U CONNECTICUT
   Purzycki BG, 2012, COGNITIVE SCI, V36, P846, DOI 10.1111/j.1551-6709.2012.01242.x
   Purzycki BG, EVOLUTION RELIG CRIT
   Purzycki BG, 2013, CURR ANTHROPOL, V54, P381, DOI 10.1086/670526
   Purzycki BG, 2013, COGNITION, V129, P163, DOI 10.1016/j.cognition.2013.06.010
   Pyysiainen I, 2010, TRENDS COGN SCI, V14, P104, DOI 10.1016/j.tics.2009.12.007
   Rappaport Roy A., 1999, RITUAL RELIG MAKING
   Ridley M., 2004, AGILE GENE NATURE TU
   Roes FL, 2003, EVOL HUM BEHAV, V24, P126, DOI 10.1016/S1090-5138(02)00134-4
   Ruffle BJ, 2007, BE J ECON ANAL POLI, V7
   Ruffle BJ, DO RELIG CONTEXTS EL
   Sanderson Stephen, 2008, EVOLUTION RELIG STUD, P67
   Schloss Jeffrey P., 2011, RELIG BRAIN BEHAV, V1, P46
   Searcy WA, 2005, MG BEH ECOL, P1
   Shariff AF, 2007, PSYCHOL SCI, V18, P803, DOI 10.1111/j.1467-9280.2007.01983.x
   Shweder R, 1987, EMERGENCE MORALITY Y, P1
   Shweder R. A., 1997, MORALITY HLTH, P119
   Sierksma F., 1963, HIST RELIGIONS, V2, P227, DOI 10.1086/462462
   Soler M, 2012, EVOL HUM BEHAV, V33, P346, DOI 10.1016/j.evolhumbehav.2011.11.004
   Sorensen Jesper, 2004, EVOLUTION COGNITION, V10, P61
   Sosis R., 2005, INTERDISCIPLINARY J, V1, P1
   Sosis R, 2007, EVOL HUM BEHAV, V28, P234, DOI 10.1016/j.evolhumbehav.2007.02.007
   Sosis R, 2003, CROSS-CULT RES, V37, P211, DOI 10.1177/1069397103251426
   Sosis R, 2004, RES ECON ANTHROPOL, V23, P89, DOI 10.1016/S0190-1281(04)23004-9
   Sosis R, 2003, CURR ANTHROPOL, V44, P713, DOI 10.1086/379260
   Sosis R., 2009, J COGNITION CULTURE, V9, P339
   Stark R, 2001, J SCI STUD RELIG, V40, P619, DOI 10.1111/0021-8294.00081
   Swanson GE, 1960, BIRTH GODS ORIGIN PR
   Tan JHW, 2008, J ECON PSYCHOL, V29, P832, DOI 10.1016/j.joep.2008.03.002
   Tooby J, 1987, PRIMATE MODELS HOMIN, P183
   Tooby J, 1992, ADAPTED MIND EVOLUTI, P163
   Turner J. S., 2000, EXTENDED ORGANISM PH
   Turner JS, 2004, BIOL PHILOS, V19, P327, DOI 10.1023/B:BIPH.0000036115.65522.a1
   Vivanti G, 2011, DEV PSYCHOL, V47, P841, DOI 10.1037/a0023105
   Voland E, 2009, FRONT COLLECT, P1, DOI 10.1007/978-3-642-00128-4
   WALLACE AFC, 1956, AM ANTHROPOL, V58, P264, DOI 10.1525/aa.1956.58.2.02a00040
   Watanabe H., 1972, HUNTERS GATHERERS TO, P448
   White L., 1952, EVOLUTION CULTURE
   Wilson David Sloan, 2002, DARWINS CATHEDRAL EV
   Zahavi A, 1997, HANDICAP PRINCIPLE M
   Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004
NR 116
TC 2
Z9 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1565-9801
EI 2224-4662
J9 ISR J ECOL EVOL
JI Isr. J. Ecol. Evol.
PY 2013
VL 59
IS 2
SI SI
BP 99
EP 108
DI 10.1080/15659801.2013.825433
PG 10
WC Ecology; Evolutionary Biology
SC Environmental Sciences & Ecology; Evolutionary Biology
GA 285IX
UT WOS:000329388500006
ER

PT S
AU Hodapp, RM
   Goldman, SE
   Urbano, RC
AF Hodapp, Robert M.
   Goldman, Samantha E.
   Urbano, Richard C.
BE Urbano, RC
TI Using Secondary Datasets in Disability Research: Special Issues, Special
   Promise
SO USING SECONDARY DATASETS TO UNDERSTAND PERSONS WITH DEVELOPMENTAL
   DISABILITIES AND THEIR FAMILIES
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID FRAGILE-X-SYNDROME; AUTISM SPECTRUM DISORDER; MILD INTELLECTUAL
   DEFICITS; DOWN-SYNDROME; DEVELOPMENTAL-DISABILITIES; MENTAL-RETARDATION;
   CHRONIC DISEASE; NATIONAL-SURVEY; ADULT SIBLINGS; YOUNG-ADULTS
AB This chapter describes how secondary datasets and analyses can be helpful within the field of intellectual and developmental disabilities. Beginning with definitional issues, we discuss the ways in which secondary datasets have both advantages (cost-effective data collection, personal advantages, growing numbers of such datasets) and disadvantages (researcher not involved in sampling procedures, constructs examined, or questions posed). Recent years have seen increasing numbers of intellectual disability articles analyzing large-scale databases, but the subfield retains a feel of being wide but shallow. Current initiatives focus on generating registries, databanks, and other large-scale datasets, and we describe here three such initiatives (Project IAN, National Fragile X Survey, NDAR). Increasingly, large-scale, secondary datasets are helping researchers address the need for information concerning individuals with intellectual disabilities and their families.
C1 [Hodapp, Robert M.; Goldman, Samantha E.; Urbano, Richard C.] Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
   [Hodapp, Robert M.; Goldman, Samantha E.] Vanderbilt Univ, Peabody Coll, Dept Special Educ, Nashville, TN 37203 USA.
   [Urbano, Richard C.] Vanderbilt Univ, Sch Med, Vanderbilt Kennedy Ctr, Dept Pediat Dev Med, Nashville, TN 37212 USA.
RP Hodapp, RM (reprint author), Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
EM robert.hodapp@vanderbilt.edu
CR Abidin RR, 1995, PARENTING STRESS IND
   [Anonymous], 2009, SHARING DATA VIA NAT
   Bailey DB, 2010, AJIDD-AM J INTELLECT, V115, P447, DOI [10.1352/1944-7558-115.6.447, 10.1352/194475581156447]
   Balogh R, 2010, J INTELL DISABIL RES, V54, P820, DOI 10.1111/j.1365-2788.2010.01311.x
   Berry-Kravis E, 2010, AJIDD-AM J INTELLECT, V115, P461, DOI [10.1352/1944-7558-115.6.461, 10.1352/194475581156461]
   Bishop E., 2009, OVERVIEW NATL FRAGIL
   Bouck EC, 2010, J INTELL DISABIL RES, V54, P1093, DOI 10.1111/j.1365-2788.2010.01339.x
   Bouck EC, 2012, J INTELL DISABIL RES, V56, P1175, DOI 10.1111/j.1365-2788.2011.01517.x
   Brooks-Gunn J, 2000, CHILD DEV, V71, P257, DOI 10.1111/1467-8624.00141
   Brown M, 2012, J INTELL DISABIL RES, V56, P1161, DOI 10.1111/j.1365-2788.2011.01511.x
   Burke MM, 2011, AJIDD-AM J INTELLECT, V116, P233, DOI 10.1352/1944-7558-116.3.233
   Burke MM, 2012, AJIDD-AM J INTELLECT, V117, P33, DOI 10.1352/1944-7558-117.1.33
   Charlot L, 2011, J INTELL DISABIL RES, V55, P199, DOI 10.1111/j.1365-2788.2010.01294.x
   Chou YC, 2010, AJIDD-AM J INTELLECT, V115, P406, DOI 10.1352/1944-7558-115.5.406
   Chowdhury M, 2010, J INTELL DISABIL RES, V54, P281, DOI 10.1111/j.1365-2788.2010.01259.x
   Cimera RE, 2010, AJIDD-AM J INTELLECT, V115, P19, DOI 10.1352/1944-7558-115.1.19
   Cooper SA, 2011, J INTELL DISABIL RES, V55, P313, DOI 10.1111/j.1365-2788.2010.01361.x
   Cordray D. S., 2001, INT ENCY SOCIAL BEHA, P13777
   Couzens D, 2011, AJIDD-AM J INTELLECT, V116, P181, DOI 10.1352/1944-7558-116.3.181
   Daniels AM, 2012, J AUTISM DEV DISORD, V42, P257, DOI 10.1007/s10803-011-1236-7
   de Graaf G, 2011, J INTELL DISABIL RES, V55, P462, DOI 10.1111/j.1365-2788.2011.01398.x
   de Kuijper G, 2010, J INTELL DISABIL RES, V54, P659, DOI 10.1111/j.1365-2788.2010.01275.x
   Department of Health and Human Services (US) Health Resources and Services Administration, 2008, NAT SURV CHILDR SPEC
   DUNCAN GJ, 1991, DEV PSYCHOL, V27, P949, DOI 10.1037//0012-1649.27.6.949
   Ellis JW, 2013, INTELLECT DEV DISAB, V51, P102, DOI 10.1352/1934-9556-51.2.102
   Emerson E, 2010, AJIDD-AM J INTELLECT, V115, P30, DOI 10.1352/1944-7558-115.1.30
   Esbensen AJ, 2010, AJIDD-AM J INTELLECT, V115, P277, DOI 10.1352/1944-7558-115.4.277
   Esbensen AJ, 2011, AJIDD-AM J INTELLECT, V116, P3, DOI 10.1352/1944-7558-116.1.3
   Fang J, 2011, J INTELL DISABIL RES, V55, P537, DOI 10.1111/j.1365-2788.2011.01401.x
   Finlayson J, 2010, J INTELL DISABIL RES, V54, P966, DOI 10.1111/j.1365-2788.2010.01319.x
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Forster S, 2011, J INTELL DISABIL RES, V55, P190, DOI 10.1111/j.1365-2788.2010.01373.x
   Fortuna RJ, 2012, ACAD PEDIATR, V12, P405, DOI 10.1016/j.acap.2012.04.002
   Freidman H. S., 2011, LONGEVITY PROJECT SU
   Fujiura GT, 2013, INTELLECT DEV DISAB, V51, P83, DOI 10.1352/1934-9556-51.2.083
   Fujiura GT, 1998, AM J MENT RETARD, V103, P225, DOI 10.1352/0895-8017(1998)103<0225:DOFH>2.0.CO;2
   Fujiura GT, 2000, EXCEPT CHILDREN, V66, P187
   Glaser B., 1963, AM BEHAV SCI, V6, P11
   Goldman SE, 2011, J INTELL DISABIL RES, V55, P85, DOI 10.1111/j.1365-2788.2010.01349.x
   Graham DJ, 2005, LANCET, V365, P475, DOI 10.1016/S0140-6736(05)17864-7
   Greenhoot AF, 2012, J COGN DEV, V13, P2, DOI 10.1080/15248372.2012.646613
   Hall D, 2012, NEUROINFORMATICS, V10, P331, DOI 10.1007/s12021-012-9151-4
   Hamrick SEG, 2010, AJIDD-AM J INTELLECT, V115, P421, DOI 10.1352/1944-7558-115-5.421
   Hartley SL, 2011, AJIDD-AM J INTELLECT, V116, P16, DOI 10.1352/1944-7558-116.1.16
   Hayes SA, 2013, J AUTISM DEV DISORD, V43, P629, DOI 10.1007/s10803-012-1604-y
   Heller T, 2012, AJIDD-AM J INTELLECT, V117, P464, DOI 10.1352/1944-7558-117.6.464
   Hodapp RM, 2010, INTELLECT DEV DISAB, V48, P52, DOI 10.1352/1934-9556-48.1.52
   Hodapp RM, 2012, INT REV RES DEV DISA, V42, P109, DOI 10.1016/B978-0-12-394284-5.00005-X
   Hodapp RM, 2009, INT REV RES MENT RET, V37, P131, DOI 10.1016/S0074-7750(09)37005-6
   Hodapp RM, 2008, J POLICY PRACT INTEL, V5, P187, DOI 10.1111/j.1741-1130.2008.00172.x
   Hofferth SL, 2005, J MARRIAGE FAM, V67, P891, DOI 10.1111/j.1741-3737.2005.00182.x
   Hsieh K, 2012, AJIDD-AM J INTELLECT, V117, P442, DOI 10.1352/1944-7558-117.6.442
   Idler EL, 1997, J HEALTH SOC BEHAV, V38, P21, DOI 10.2307/2955359
   Iezzoni LI, 2002, MILBANK Q, V80, P347, DOI 10.1111/1468-0009.t01-1-00007
   Isaacs B, 2012, J INTELL DISABIL RES, V56, P17, DOI 10.1111/j.1365-2788.2011.01392.x
   John O. P., 1992, J PERS, V60, P175
   Jones L, 2012, LANCET, V380, P899, DOI 10.1016/S0140-6736(12)60692-8
   Kalb LG, 2012, J AM MED INFORM ASSN, V19, P668, DOI 10.1136/amiajnl-2012-000863
   Kern ML, 2009, ANN BEHAV MED, V37, P154, DOI 10.1007/s12160-009-9095-6
   Kern ML, 2008, HEALTH PSYCHOL, V27, P505, DOI 10.1037/0278-6133.27.5.505
   Kogan M. D., 2009, PEDIATRICS, V124, P1
   Heller T, 2009, INTELLECT DEV DISAB, V47, P208, DOI 10.1352/1934-9556-47.3.208
   Kuppens S, 2010, AJIDD-AM J INTELLECT, V115, P327, DOI 10.1352/1944-7558-115.4.327
   Leonard H, 2002, MENT RETARD DEV D R, V8, P117, DOI 10.1002/mrdd.10031
   Lindsay W, 2012, J INTELL DISABIL RES, V56, P326, DOI 10.1111/j.1365-2788.2011.01428.x
   Lindsay WR, 2010, AJIDD-AM J INTELLECT, V115, P250, DOI 10.1352/1944-7558-115.3.250
   Lipsey M. W., 2001, APPL SOCIAL RES METH, V49
   MCCALL RB, 1991, DEV PSYCHOL, V27, P911, DOI 10.1037/0012-1649.27.6.911
   McConkey R, 2011, AJIDD-AM J INTELLECT, V116, P305, DOI 10.1352/1944-7558-116.4.305
   McManus BM, 2011, AJIDD-AM J INTELLECT, V116, P246, DOI 10.1352/1944-7558-116.3.246
   Mitchell G, 2012, PERSPECT PSYCHOL SCI, V7, P109, DOI 10.1177/1745691611432343
   Morin D, 2012, AJIDD-AM J INTELLECT, V117, P455, DOI 10.1352/1944-7558-117.6.455
   Muthen BO, 1997, PSYCHOL METHODS, V2, P371, DOI 10.1037//1082-989X.2.4.371
   National Institutes of Health, 2007, SCI UPDATE      1030
   Obi O, 2011, AJIDD-AM J INTELLECT, V116, P360, DOI 10.1352/1944-7558-116.5.360
   Olley JG, 2013, INTELLECT DEV DISAB, V51, P117, DOI 10.1352/1934-9556-51.2.117
   Orsmond GI, 2000, AM J MENT RETARD, V105, P486, DOI 10.1352/0895-8017(2000)105<0486:BASOAW>2.0.CO;2
   Ouyang L, 2010, J INTELL DISABIL RES, V54, P918, DOI 10.1111/j.1365-2788.2010.01320.x
   Parish S, 2012, AJIDD-AM J INTELLECT, V117, P304, DOI 10.1352/1944-7558-117.4.304
   Parish SL, 2008, EXCEPT CHILDREN, V75, P71
   Parish SL, 2012, AJIDD-AM J INTELLECT, V117, P400, DOI 10.1352/1944-7558-117.5.400
   Paton C, 2011, J INTELL DISABIL RES, V55, P665, DOI 10.1111/j.1365-2788.2011.01421.x
   Povee K, 2012, J INTELL DISABIL RES, V56, P961, DOI 10.1111/j.1365-2788.2012.01561.x
   Rammstedt B, 2007, J RES PERS, V41, P203, DOI 10.1016/j.jrp.2006.02.001
   Raspa M, 2010, AJIDD-AM J INTELLECT, V115, P482, DOI [10.1352/1944-7558-115.6.482, 10.1352/194475581156482]
   Reid KA, 2011, J INTELL DISABIL RES, V55, P172, DOI 10.1111/j.1365-2788.2010.01360.x
   Rimmer JH, 2010, J INTELL DISABIL RES, V54, P787, DOI 10.1111/j.1365-2788.2010.01305.x
   Risdal D, 2004, RES PRACT PERS SEV D, V29, P95, DOI 10.2511/rpsd.29.2.95
   Roizen NJ, 2010, INT REV RES MENT RET, V39, P3, DOI 10.1016/S0074-7750(10)39001-X
   Rosenberg RE, 2009, J AUTISM DEV DISORD, V39, P1099, DOI 10.1007/s10803-009-0723-6
   Schalock RL, 2013, INTELLECT DEV DISAB, V51, P86, DOI 10.1352/1934-9556-51.2.086
   Seltzer MM, 2011, AJIDD-AM J INTELLECT, V116, P479, DOI 10.1352/1944-7558-116.6.479
   Smith AK, 2011, J GEN INTERN MED, V26, P920, DOI 10.1007/s11606-010-1621-5
   Smith E, 2008, BRIT J EDUC STUD, V56, P323, DOI 10.1111/j.1467-8527.2008.00405.x
   Sondenaa E, 2010, J INTELL DISABIL RES, V54, P161, DOI 10.1111/j.1365-2788.2009.01230.x
   Stancliffe RJ, 2011, AJIDD-AM J INTELLECT, V116, P401, DOI 10.1352/1944-7558-116.6.401
   Symons FJ, 2010, AJIDD-AM J INTELLECT, V115, P473, DOI [10.1352/1944-7558-115.6.473, 10.1352/194475581156473]
   Tanner-Smith E. T., 2013, ADVERSE HLTH E UNPUB
   Taylor JL, 2010, AJIDD-AM J INTELLECT, V115, P340, DOI 10.1352/1944-7558-115.4.340
   Taylor JL, 2012, AJIDD-AM J INTELLECT, V117, P67, DOI 10.1352/1944-7558-117.1.67
   Taylor JL, 2011, AJIDD-AM J INTELLECT, V116, P263, DOI 10.1352/1944-7558-116.3.263
   Terman L., 1925, GENETIC STUDIES GENI
   Terman L., 1959, GIFTED GROUP MIDLIFE
   Tyler CV, 2011, AJIDD-AM J INTELLECT, V116, P371, DOI 10.1352/1944-7558-116.5.371
   Urv TK, 2010, AJIDD-AM J INTELLECT, V115, P265, DOI 10.1352/1944-7558-115.4.265
   van Dijk E, 2012, J INTELL DISABIL RES, V56, P204, DOI 10.1111/j.1365-2788.2011.01458.x
   Verdine BN, 2008, AM J MENT RETARD, V113, P343, DOI 10.1352/2008.113:342-355
   Wade C, 2011, AJIDD-AM J INTELLECT, V116, P419, DOI 10.1352/1944-7558-116.6.419
   Wisconsin Longitudinal Study, 2013, WLS GRADUATES SIBLIN
   Xenitidis K, 2010, J INTELL DISABIL RES, V54, P668, DOI 10.1111/j.1365-2788.2010.01270.x
   Yang P, 2011, J INTELL DISABIL RES, V55, P453, DOI 10.1111/j.1365-2788.2011.01396.x
   Zablotsky B, 2012, AJIDD-AM J INTELLECT, V117, P316, DOI 10.1352/1944-7558-117.4.316
   Zheng X, 2012, J INTELL DISABIL RES, V56, P212, DOI 10.1111/j.1365-2788.2011.01470.x
NR 113
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-407760-7
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 45
BP 1
EP 34
DI 10.1016/B978-0-12-407760-7.00001-3
PG 34
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BJN47
UT WOS:000329255200002
ER

PT S
AU Novikova, SI
   Richman, DM
   Supekar, K
   Barnard-Brak, L
   Hall, D
AF Novikova, S. I.
   Richman, D. M.
   Supekar, K.
   Barnard-Brak, L.
   Hall, D.
BE Urbano, RC
TI NDAR: A Model Federal System for Secondary Analysis in Developmental
   Disabilities Research
SO USING SECONDARY DATASETS TO UNDERSTAND PERSONS WITH DEVELOPMENTAL
   DISABILITIES AND THEIR FAMILIES
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID ABERRANT BEHAVIOR CHECKLIST; AUTISM SPECTRUM DISORDERS;
   SELF-INJURIOUS-BEHAVIOR; EXECUTIVE FUNCTIONS; MISSING DATA; CHILDREN;
   CLASSIFICATION; INDIVIDUALS; SEVERITY; ADHD
AB The National Database for Autism Research (NDAR) is a human-subject data repository on tens of thousands of research participants. Approved researchers have access to an unprecedented volume of item-level clinical, genomic, and imaging data. Data are shared quickly using both a common data standard and innovative tools for experiment definition, which provide the level of detail needed for efficient use of the repository. As described, early adopters have used it to conduct secondary data analysis. Now, with an ever-increasing volume of research data being made available, and new methods for data query, data download, and computation in place, this initiative is becoming vital to those interested in scientific discovery in autism or is being used as a model by other research communities.
C1 [Novikova, S. I.; Hall, D.] OMNITEC Solut Inc, NIMH, Natl Database Autism Res, Rockville, MD USA.
   [Richman, D. M.; Barnard-Brak, L.] Texas Tech Univ, Lubbock, TX 79409 USA.
   [Supekar, K.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
RP Novikova, SI (reprint author), OMNITEC Solut Inc, NIMH, Natl Database Autism Res, Rockville, MD USA.
EM svetlana.novikova@nih.gov
CR Allison PD, 2003, J ABNORM PSYCHOL, V112, P545, DOI 10.1037/0021-843X.112.4.545
   AMAN MG, 1985, AM J MENT DEF, V89, P485
   AMAN MG, 1985, AM J MENT DEF, V89, P492
   [Anonymous], 2007, NIH FUNDS NEW PROGR
   [Anonymous], 2009, SHARING DATA VIA NAT
   [Anonymous], AUTISM
   Arron K, 2011, J INTELL DISABIL RES, V55, P109, DOI 10.1111/j.1365-2788.2010.01337.x
   Barkley RA, 1997, PSYCHOL BULL, V121, P65, DOI 10.1037//0033-2909.121.1.65
   Brinkley J, 2007, J AUTISM DEV DISORD, V37, P1949, DOI 10.1007/s10803-006-0327-3
   Bruininks R., 1996, SCALES INDEPENDENT B
   Byrne B. M., 2011, STRUCTURAL EQUATION
   Chang Chih-Chung, 2011, ACM T SYS TECH, V2, P27
   De Martino F, 2008, NEUROIMAGE, V43, P44, DOI 10.1016/j.neuroimage.2008.06.037
   Enders CK, 2001, STRUCT EQU MODELING, V8, P128, DOI 10.1207/S15328007SEM0801_7
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Frederick K. E., 2012, INT J RES METHOD ED, V35, P31
   Good CD, 2001, NEUROIMAGE, V14, P21, DOI 10.1006/nimg.2001.0786
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Hall D, 2012, NEUROINFORMATICS, V10, P331, DOI 10.1007/s12021-012-9151-4
   Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
   Johnson SB, 2010, J AM MED INFORM ASSN, V17, P689, DOI 10.1136/jamia.2009.002063
   Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
   Lambek R, 2010, J CHILD PSYCHOL PSYC, V51, P895, DOI 10.1111/j.1469-7610.2010.02248.x
   Lohr S., 2010, SAMPLING DESIGN ANAL
   Lopez BR, 2005, J AUTISM DEV DISORD, V35, P445, DOI 10.1007/s10803-005-5035-x
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   MARSHBURN EC, 1992, J AUTISM DEV DISORD, V22, P357, DOI 10.1007/BF01048240
   Muthen L. K., 2008, MPLUS USERS GUIDE
   National Longitudinal Transition Study (NLTS-2), 2005, NLTS 2 DAT DOC DICT
   Oliver C., 2011, J AUTISM DEV DISORD, V37, P1
   Piwowar HA, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000308
   Poline JB, 2012, FRONT NEUROINFORM, V6, DOI 10.3389/fninf.2012.00009
   Richards C, 2012, J INTELL DISABIL RES, V56, P476, DOI 10.1111/j.1365-2788.2012.01537.x
   Richman DM, 2013, J INTELL DISABIL RES, V57, P429, DOI 10.1111/j.1365-2788.2012.01628.x
   Savage CJ, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007078
   Schermelleh-Engel K., 2003, METHODS PSYCHOL RES, V8, P23
   Smith E, 2008, USING SECONDARY DATA
   Special Education Elementary Longitudinal Study (SEELS), 2005, SEELS DAT DOC DICT I
   Supekar K., 2013, 2013 INT M IN PRESS
   Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278
   Uddin LQ, 2011, BIOL PSYCHIAT, V70, P833, DOI 10.1016/j.biopsych.2011.07.014
   Uddin LQ, 2013, JAMA PSYCHIAT, V70, P869, DOI 10.1001/jamapsychiatry.2013.104
   Valdes K., 2007, SPECIAL ED ELEMENTAR
   van den Wittenboer G., 2003, RECENT DEV STRUCTURA
   Weston R, 2006, COUNS PSYCHOL, V34, P719, DOI 10.1177/0011000006286345
NR 45
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-407760-7
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 45
BP 123
EP 153
DI 10.1016/B978-0-12-407760-7.00003-7
PG 31
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BJN47
UT WOS:000329255200004
ER

PT S
AU Griffin, MM
   Steinbrecher, TD
AF Griffin, Megan M.
   Steinbrecher, Trisha D.
BE Urbano, RC
TI Large-Scale Datasets in Special Education Research
SO USING SECONDARY DATASETS TO UNDERSTAND PERSONS WITH DEVELOPMENTAL
   DISABILITIES AND THEIR FAMILIES
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID AUTISM SPECTRUM DISORDER; EARLY INTERVENTION;
   DEVELOPMENTAL-DISABILITIES; STUDENTS; CHILDREN; YOUTH; PARTICIPATION;
   PREVALENCE; SERVICES
AB Large-scale datasets are integral to building a national understanding of the educational experiences of children and youth with disabilities. These datasets often include a wealth of variables, and many allow the researcher to examine change over time; however, implementing large-scale dataset studies can be challenging for both novice and experienced researchers. In this chapter, we begin by reviewing several large-scale, national datasets related to education that include children and youth with disabilities. We then outline a variety of benefits, challenges, and considerations for investigators who are in the initial stages of conducting research with large-scale datasets. Next, we present an example detailing the preliminary steps in analyzing large-scale data. The chapter concludes with a brief discussion of other datasets that do not focus on educational issues; we address their potential utility for special education researchers, and discuss recently developed resources to assist new investigators in using these data sources.
C1 [Griffin, Megan M.; Steinbrecher, Trisha D.] Univ New Mexico, Dept Educ Specialties, Special Educ Program, Albuquerque, NM 87131 USA.
RP Griffin, MM (reprint author), Univ New Mexico, Dept Educ Specialties, Special Educ Program, Albuquerque, NM 87131 USA.
EM griffinm@unm.edu
CR [Anonymous], DAT TABL
   Aud S., 2012, 2012045 NCES US DEP
   Bailey DB, 2004, PEDIATRICS, V113, P887, DOI 10.1542/peds.113.4.887
   Bouck EC, 2011, EDUC TRAIN AUTISM DE, V46, P399
   Bowman-Perrott L., 2011, J EMOT BEHAV DISORD, V21, P83
   Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
   Brown T. A., 2006, CONFIRMATORY FACTOR
   Buckley J. A., 2007, 2007005 NCES
   Butterworth J., 2012, STATEDATA NATL REPOR
   Daley TC, 2009, EXCEPT CHILDREN, V75, P412
   Early Childhood Longitudinal Study (ECLS) Program, SAMPL SEL
   Feinberg E, 2011, J DEV BEHAV PEDIATR, V32, P284, DOI 10.1097/DBP.0b013e3182142fbd
   Feinberg E, 2012, MATERN CHILD HLTH J, V16, P336, DOI 10.1007/s10995-010-0715-3
   Fuchs L., 2008, J DISABIL POLICY STU, V19, P153, DOI DOI 10.1177/1044207308327471
   Graham J. W., 2003, HDB PSYCHOL RES METH, V2, P87, DOI DOI 10.1002/0471264385.WEI0204
   Graham JW, 2007, PREV SCI, V8, P206, DOI 10.1007/s11121-007-0070-9
   Griffin M. M., 2013, J SPECIAL ED
   Gullo D. F., 2013, EARLY CHILDHOOD ED J, P1
   Halle T, 2009, DISPARITIES EARLY LE
   Hamiliton L. S., 2006, MAKING SENSE DATA DR
   Hebbeler K., 2007, EARLY INTERVENTION I
   Hibel J, 2010, SOCIOL EDUC, V83, P312, DOI 10.1177/0038040710383518
   Hodapp RM, 2009, INT REV RES MENT RET, V37, P131, DOI 10.1016/S0074-7750(09)37005-6
   Karpur A., 2013, NEW RES TOOLS EXPLOR
   Kline R. B., 2005, PRINCIPLES PRACTICE, V2nd
   Kluwin TN, 2006, AM ANN DEAF, V151, P121, DOI 10.1353/aad.2006.0028
   Little R. J., 1987, STAT ANAL MISSING DA
   Markowitz J., 2006, PRESCHOOLERS CHARACT
   MCGREW KS, 1993, EDUC EVAL POLICY AN, V15, P339, DOI 10.3102/01623737015003339
   Morgan PL, 2012, EDUC RESEARCHER, V41, P339, DOI 10.3102/0013189X12459678
   Morgan PL, 2010, J SPEC EDUC, V43, P236, DOI 10.1177/0022466908323007
   National Center for Education Statistics (NCES), 2001, 2001035 NCES
   Newman L., 2010, COMPARISONS TIME OUT
   Newman L., 2005, FAMILY INVOLVEMENT E
   Newman L., 2011, 20123000 NCSER US DE
   Rosenberg SA, 2008, PEDIATRICS, V121, pE1503, DOI 10.1542/peds.2007-1680
   Sagebrush Corporation, 2004, DAT DRIV DEC MAK POW
   Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
   Shattuck PT, 2011, ARCH PEDIAT ADOL MED, V165, P141, DOI 10.1001/archpediatrics.2010.279
   Shattuck PT, 2012, PEDIATRICS, V129, P1042, DOI 10.1542/peds.2011-2864
   Shogren KA, 2012, INTELLECT DEV DISAB, V50, P16, DOI 10.1352/1934-9556-50.1.16
   SRI International, NLTS2 STUD DES SAMPL
   Steinbrecher T. D., 2012, DISS ABSTR INT A, P73
   Steinbrecher TD, 2013, EXCEPT CHILDREN, V79, P313
   Stump K. N., 2008, MISSING DATA LARGE D
   Tabachnick B., 2007, USING MULTIVARIATE S, V5th
   Tourangeau K, 2006, 2006032 NCES
   Vanderwood M, 1998, EXCEPT CHILDREN, V64, P359
   Wagner M, 2012, J DISABIL POLICY STU, V23, P140, DOI 10.1177/1044207311425384
   Wagner M., 2004, OVERVIEW FINDINGS WA
   Wagner M, 2012, PSYCHIATR REHABIL J, V35, P199, DOI 10.2975/35.3.2012.199.208
   West J., 2001, KINDERGARTEN YEAR
   West J., 2004, 2005036 NCES US DEP
   Woythaler MA, 2011, PEDIATRICS, V127, pE622, DOI 10.1542/peds.2009-3598
NR 54
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-407760-7
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 45
BP 155
EP 183
DI 10.1016/B978-0-12-407760-7.00004-9
PG 29
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BJN47
UT WOS:000329255200005
ER

PT S
AU Parish, SL
   Magana, S
   Swaine, JG
   Son, E
AF Parish, Susan L.
   Magana, Sandra
   Swaine, Jamie G.
   Son, Esther
BE Urbano, RC
TI Studying Racial and Ethnic Health Care Disparities Among Children with
   Intellectual and Developmental Disabilities Using the National Survey of
   Children with Special Health Care Needs
SO USING SECONDARY DATASETS TO UNDERSTAND PERSONS WITH DEVELOPMENTAL
   DISABILITIES AND THEIR FAMILIES
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID FAMILY-CENTERED CARE; MEDICAL HOME; UNITED-STATES; FINANCIAL BURDEN;
   LATINO CHILDREN; AUTISM; ACCESS; QUALITY; SERVICES; YOUTH
AB Background:There is strong evidence that racial and ethnic minorities have worse health care and health outcomes in the United States. However, little is known about racial and ethnic disparities among children with intellectual and developmental disabilities.
   Method: Using data from the 2009/2010 National Survey of Children with Special Health Care Needs, we examined racial and ethnic disparities in the receipt of a medical home among children with intellectual and developmental disabilities, whether these disparities are moderated by family income, and the impact of parent's language on disparities among the Latino sample. Descriptive bivariate and multivariate logistic regression analyses were performed.
   Results: There were significant racial disparities in health outcomes between Black and White children and Latino and non-Latino White children. The majority of children in the study, regardless of race or ethnicity, did not meet the criteria for having a medical home. Only 31% of White, 23% of Black children, and 22% of Latino children had a medical home. Racial and ethnic disparities in usual source of care were exacerbated at lower income levels. Surprisingly, Spanish-speaking Latino parents were more likely to report their child had a personal doctor than English-speaking Latino parents.
   Conclusion: This study provides evidence of racial and ethnic health care disparities among children with intellectual and developmental disabilities. Furthermore, this study provides troubling evidence of the small percentage of children in this population who meet medical home criteria. Assertive policy and practice measures are needed not only to reduce racial and ethnic disparities but also to increase the number of children with intellectual and developmental disabilities who have a medical home.
C1 [Parish, Susan L.; Swaine, Jamie G.; Son, Esther] Brandeis Univ, Heller Sch Social Policy & Management, Lurie Inst Disabil Policy, Boston, MA USA.
   [Magana, Sandra] Univ Illinois, Dept Disabil & Human Dev, Chicago, IL USA.
   [Swaine, Jamie G.] Univ N Carolina, Sch Social Work, Chapel Hill, NC USA.
RP Parish, SL (reprint author), Brandeis Univ, Heller Sch Social Policy & Management, Lurie Inst Disabil Policy, Boston, MA USA.
EM slp@Brandeis.edu
CR Acevedo-Garcia D, 2008, HEALTH AFFAIR, V27, P321, DOI [10.1377/hlthaff.27.2.321, 10.1077/hlthaff.27.2.321]
   Agency for Health care Research and Quality, 2011, AHRQ PUBL, V10(11)-EHC063-EF
   American Academy of Family Physicians American Academy of Pediatrics American College of Physicians & American Osteopathic Association, 2007, JOINT PRINC PAT CTR
   Sia CJ, 2002, PEDIATRICS, V110, P184
   DICKENS MD, 1992, PEDIATRICS, V90, P774
   American Academy of Pediatrics Medical Home Initiatives for Children With Special Needs Project Advisory Committee, 2004, PEDIATRICS, V113, P1545
   Berdahl T, 2010, ACAD PEDIATR, V10, P95, DOI 10.1016/j.acap.2009.12.005
   Blumberg SJ, 2008, VITAL HLTH STAT, V1, P1
   Centers for Disease Control and Prevention National Center for Health Statistics, 2011, 2009 2010 NAT SURV C
   Coker TR, 2010, PEDIATRICS, V125, P1159, DOI 10.1542/peds.2009-1994
   Commission on Social Determinants of Health, 2008, CLOS GAP GEN HLTH EQ
   Cooley WC, 2009, PEDIATRICS, V124, P358, DOI 10.1542/peds.2008-2600
   DeCamp LR, 2011, J HEALTH CARE POOR U, V22, P1151, DOI 10.1353/hpu.2011.0113
   Flores G, 2010, PEDIATRICS, V125, pE979, DOI 10.1542/peds.2010-0188
   Heidgerken AD, 2005, J AUTISM DEV DISORD, V35, P323, DOI 10.1007/s10803-005-3298-x
   Homer CJ, 2008, PEDIATRICS, V122, pE922, DOI 10.1542/peds.2007-3762
   Kenney MK, 2011, ACAD PEDIATR, V11, P144, DOI 10.1016/j.acap.2010.08.001
   Lee E. S., 2006, ANAL COMPLEX SURVEY, V2nd
   Lin Sue C, 2012, Pediatrics, V130 Suppl 2, pS191, DOI 10.1542/peds.2012-0900R
   Long WE, 2012, PEDIATRICS, V129, P87, DOI 10.1542/peds.2011-1739
   Magana S, 2012, INTELLECT DEV DISAB, V50, P287, DOI 10.1352/1934-9556-50.4.287
   McPherson M, 1998, PEDIATRICS, V102, P137, DOI 10.1542/peds.102.1.137
   Miles DR, 2011, DISABIL HEALTH J, V4, P185, DOI 10.1016/j.dhjo.2011.03.004
   Montes G, 2011, ACAD PEDIATR, V11, P297, DOI 10.1016/j.acap.2011.02.002
   Nageswaran S, 2011, MATERN CHILD HLTH J, V15, P634, DOI 10.1007/s10995-010-0597-4
   National Institute on Disability and Rehabilitation Research, 2006, FED RES         0215, V71, P8166
   Nelson A., 2002, UNEQUAL TREATMENT CO
   Osypuk TL, 2010, HEALTH PLACE, V16, P1113, DOI 10.1016/j.healthplace.2010.07.002
   Parish S, 2012, AJIDD-AM J INTELLECT, V117, P304, DOI 10.1352/1944-7558-117.4.304
   Parish S, 2012, INTELLECT DEV DISAB, V50, P190, DOI 10.1352/1934-9556-50.3.190
   Parish SL, 2012, INTELLECT DEV DISAB, V50, P441, DOI 10.1352/1934-9556-50.06.441
   Patient-Centered Medical Homes, 2010, HLTH AFF
   Raphael JL, 2009, ACAD PEDIATR, V9, P221, DOI 10.1016/j.acap.2009.01.011
   Reichard A, 2004, MENT RETARD, V42, P181, DOI 10.1352/0047-6765(2004)42<181:POPFAC>2.0.CO;2
   Sia C, 2004, PEDIATRICS, V113, P1473
   Strickland B, 2004, PEDIATRICS, V113, P1485
   Strickland BB, 2009, PEDIATRICS, V123, pE996, DOI 10.1542/peds.2008-2504
   Strickland BB, 2011, PEDIATRICS, V127, P604, DOI 10.1542/peds.2009-3555
   The Child and Adolescent Health Measurement Initiative, 2009, MEAS MED HOM CHILDR
   Thomas KC, 2012, MATERN CHILD HLTH J, V16, P1636, DOI 10.1007/s10995-011-0862-1
   U. S. Department of Health and Human Services, 2011, HHS ACT PLAN RED RAC
   U. S. Department of Health and Human Services, 2000, HLTH PEOPL 2010, V2nd
   U. S. Department of Health and Human Services. Office of Disease Prevention and Health Promotion, HLTH PEOPL 2020
   U.S. Department of Health and Human Services, 2002, SURG GEN C HLTH DISP
   US Department of Health and Human Services Office of the Surgeon General, 2005, SURG GEN CALL ACT IM
   Yu Stella M, 2009, Pediatrics, V124 Suppl 4, pS414, DOI 10.1542/peds.2009-1255M
   Yu SM, 2006, AM J PUBLIC HEALTH, V96, P1449, DOI 10.2105/AJPH.2005.069500
NR 47
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-407760-7
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 45
BP 185
EP 224
DI 10.1016/B978-0-12-407760-7.00005-0
PG 40
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BJN47
UT WOS:000329255200006
ER

PT S
AU Leonard, H
   Glasson, E
   Bebbington, A
   Hammond, G
   Croft, D
   Pikora, T
   Fairthorne, J
   O'Donnell, M
   O'Leary, C
   Hansen, M
   Watson, L
   Francis, RW
   Carter, KW
   McKenzie, A
   Bower, C
   Bourke, J
AF Leonard, Helen
   Glasson, Emma
   Bebbington, Ami
   Hammond, Geoff
   Croft, Deirdre
   Pikora, Terri
   Fairthorne, Jenny
   O'Donnell, Melissa
   O'Leary, Colleen
   Hansen, Michele
   Watson, Linda
   Francis, Richard W.
   Carter, Kim W.
   McKenzie, Anne
   Bower, Carol
   Bourke, Jenny
BE Urbano, RC
TI Application of Population-Based Linked Data to the Study of Intellectual
   Disability and Autism
SO USING SECONDARY DATASETS TO UNDERSTAND PERSONS WITH DEVELOPMENTAL
   DISABILITIES AND THEIR FAMILIES
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID FETAL ALCOHOL SYNDROME; IN-VITRO FERTILIZATION; INTRACYTOPLASMIC SPERM
   INJECTION; NEURAL-TUBE DEFECTS; WESTERN-AUSTRALIA; CEREBRAL-PALSY;
   SPECTRUM DISORDERS; MENTAL-RETARDATION; BIRTH-DEFECTS; CHILD
   MALTREATMENT
AB Data linkage is the bringing together of specific datasets from different sources using demographic information on individuals within a population. In Western Australia, systematic record linkages between multiple datasets including births, deaths, and hospital morbidity have occurred since 1997. Linkage to other population datasets related to intellectual disability and autism provides an infrastructure to undertake research in this area. The purpose of this chapter is to use the Western Australian experience to describe the potential of data linkage to improve the understanding of the epidemiology of intellectual disability and autism.
   Information is provided on the core datasets and specific disability registers available in Western Australia. Some recently developed novel initiatives are also described. One of these involves the linkage of data from a number of other Western Australian jurisdictions such as education, child protection, and justice in addition to health. The other uses a federated approach, developed by the bioinformatics team at the Tele-thon Institute for Child Health Research, to enable analysis of autism risk factors from international population-based datasets without the data leaving its home base.
   Examples of published research examining both determinants and outcomes of intellectual disability and autism are reported as well as information on several studies, which are in the planning stages. We also include a section on some of the challenges of data management and describe some of the statistical techniques that have been used.
   Studies investigating sociodemographic factors, prenatal growth, alcohol exposure, and maternal physical health have identified risk factors associated with intellectual disability and autism. Analyses of outcomes for these children have shown an increased risk of hospitalizations from two to ten times that of the rest of the population. For those with Down syndrome, a quarter of their admissions occurred in the first year of life, with upper respiratory tract infections being the most common cause. Non-Aboriginal children with intellectual disability were shown to have a threefold risk of substantiated child maltreatment and Aboriginal children a twofold risk, after taking parental factors into account. Linked data studies using population data on intellectual disability and autism can help understand the complex multidimensional factors contributing to different outcomes for this particularly vulnerable and underresearched population and provide valuable information for informing policies and programs.
C1 [Leonard, Helen; Glasson, Emma; Bebbington, Ami; Hammond, Geoff; Croft, Deirdre; Pikora, Terri; Fairthorne, Jenny; O'Donnell, Melissa; O'Leary, Colleen; Hansen, Michele; Watson, Linda; Francis, Richard W.; Carter, Kim W.; McKenzie, Anne; Bower, Carol; Bourke, Jenny] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Perth, WA, Australia.
   [McKenzie, Anne] Univ Western Australia, Sch Populat Hlth, Perth, WA, Australia.
RP Leonard, H (reprint author), Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Perth, WA, Australia.
EM hleonard@ichr.uwa.edu.au
RI O'Donnell, Melissa/H-5555-2014; Leonard, Helen/A-1010-2013
OI Leonard, Helen/0000-0001-6405-5834
CR ABEL EL, 1986, LANCET, V2, P1222
   ABEL EL, 1987, DRUG ALCOHOL DEPEN, V19, P51, DOI 10.1016/0376-8716(87)90087-1
   ACHESON ED, 1964, BRIT J PREV SOC MED, V18, P8
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   ANDERSEN PK, 1982, ANN STAT, V10, P1100, DOI 10.1214/aos/1176345976
   ATKINSON S, 1983, DEV MED CHILD NEUROL, V25, P693
   Australian Bureau of Statistics, 2008, AUSTR SOC TRENDS FAM
   Australian Institute of Health and Welfare, 2008, AUSTR I HLTH WELF B, V67
   Badawi N, 2005, DEV MED CHILD NEUROL, V47, P293, DOI 10.1017/S0012162205000575
   Badawi N, 1998, DEV MED CHILD NEUROL, V40, P520
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Balogh R, 2010, J INTELL DISABIL RES, V54, P820, DOI 10.1111/j.1365-2788.2010.01311.x
   Balogh RS, 2005, J APPL RES INTELLECT, V18, P181, DOI 10.1111/j.1468-3148.2005.00247.x
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Bay B, 2013, FERTIL STERIL, V100, P844, DOI 10.1016/j.fertnstert.2013.05.034
   Bebbington A., 2013, BMJ OPEN, V3
   Bertrand J, 2001, PEDIATRICS, V108, P1155, DOI 10.1542/peds.108.5.1155
   Blair E, 2001, DEV MED CHILD NEUROL, V43, P508, DOI 10.1017/S0012162201000949
   Bourke J, 2008, J PEDIATR-US, V153, P320, DOI 10.1016/j.jpeds.2008.02.047
   BOWER C, 1989, MED J AUSTRALIA, V150, P613
   Bower C, 2000, J PAEDIATR CHILD H, V36, P574, DOI 10.1046/j.1440-1754.2000.00575.x
   BOWER C, 1989, MED J AUSTRALIA, V150, P61
   Bower C, 2011, W AUSTR REGISTER DEV
   Bower C, 2001, TERATOLOGY, V63, P23, DOI 10.1002/1096-9926(200101)63:1<23::AID-TERA1004>3.0.CO;2-S
   Bower C., 2006, REPORT BIRTH DEFECTS, V14
   BOWER C, 1992, MED J AUSTRALIA, V156, P520
   Centers for Disease Control and Prevention, 2004, FET ALC SYND GUID RE
   Chudley AE, 2005, CAN MED ASSOC J, V172, pS1, DOI 10.1503/cmaj.1040302
   Cleves M. A., 2004, INTRO SURVIVAL ANAL
   Colvin J, 2005, PEDIATRICS, V116, pE356, DOI 10.1542/peds.2004-2845
   Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880
   Daniels J, 2008, PEDIATRICS, V121, P1357
   Data Linkage Western Australia, 2010, EN HLTH MED RES W AU
   Department of Health, 2006, GUID COMPL NOT CAS A
   Dyke P, 2013, J INTELLECT DEV DIS, V38, P149, DOI 10.3109/13668250.2013.789099
   Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x
   Fairthorne J., 2013, RECENT ADV AUTISM SP, P387
   Fitzgerald P., 2013, PLOS ONE, V13
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Francis R. W., 2013, BIOINFORMATICS
   Glasson E, 2008, J INTELLECT DEV DIS, V33, P285, DOI 10.1080/13668250802441409
   Glasson EJ, 2008, MED J AUSTRALIA, V188, P288
   Glasson EJ, 2004, MED J AUSTRALIA, V181, P514
   Glasson EJ, 2002, J PAEDIATR CHILD H, V38, P321, DOI 10.1046/j.1440-1754.2002.00859.x
   Glasson EJ, 2008, INT J EPIDEMIOL, V37, P30, DOI 10.1093/ije/dym136
   Gronborg T. K., 2013, J AUTISM DEV DISORDE
   Heagerty PJ, 2000, STAT SCI, V15, P1
   HEBER R, 1961, AM J MENT DEF, V65, P499
   Hemsley B, 2007, J AGING STUD, V21, P239, DOI 10.1016/j.jaging.2006.12.001
   Holman CDJ, 1999, AUST NZ J PUBL HEAL, V23, P453, DOI 10.1111/j.1467-842X.1999.tb01297.x
   Holman CDJ, 2008, AUST HEALTH REV, V32, P766
   Hvidtjorn D, 2009, ARCH PEDIAT ADOL MED, V163, P72, DOI 10.1001/archpediatrics.2008.507
   Iacono T, 2003, RES DEV DISABIL, V24, P247, DOI 10.1016/S0891-4222(03)00041-6
   Kallen B, 2005, FERTIL STERIL, V84, P605, DOI 10.1016/j.fertnstert.2005.03.035
   KALUCY M, 1994, PAEDIATR PERINAT EP, V8, P334, DOI 10.1111/j.1365-3016.1994.tb00467.x
   Klemetti R, 2006, PEDIATRICS, V118, P1819, DOI 10.1542/peds.2006-0735
   Kurinczuk JJ, 2002, J PAEDIATR CHILD H, V38, P187, DOI 10.1046/j.1440-1754.2002.00812.x
   Langridge AT, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0050963
   Last JM, 1995, DICT EPIDEMIOLOGY
   LEE EW, 1992, NATO ADV SCI I E-APP, V211, P237
   Leonard H, 2002, MENT RETARD DEV D R, V8, P117, DOI 10.1002/mrdd.10031
   Leonard H, 2005, SOC SCI MED, V60, P1499, DOI 10.1016/j.socscimed.2004.08.014
   Leonard H, 2008, AM J EPIDEMIOL, V167, P103, DOI 10.1093/aje/kwm245
   Leonard H, 2010, RES AUTISM SPECT DIS, V4, P548, DOI 10.1016/j.rasd.2010.01.003
   Leonard H, 2003, PAEDIATR PERINAT EP, V17, P58, DOI 10.1046/j.1365-3016.2003.00469.x
   Leonard H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017875
   Leonard H, 2006, ANN EPIDEMIOL, V16, P448, DOI 10.1016/j.annepidem.2005.05.002
   Leonard S, 2000, PAEDIATR PERINAT EP, V14, P163
   Leunens L, 2006, HUM REPROD, V21, P2922, DOI 10.1093/humrep/del266
   Mansell J, 2006, J INTELLECT DEV DIS, V31, P65, DOI 10.1080/13668250600686726
   Mattson SN, 1997, J PEDIATR-US, V131, P718, DOI 10.1016/S0022-3476(97)70099-4
   May PA, 2009, DEV DISABIL RES REV, V15, P176, DOI 10.1002/ddrr.68
   Morgan VA, 2008, BRIT J PSYCHIAT, V193, P364, DOI 10.1192/bjp.bp.107.044461
   Nassar N, 2009, INT J EPIDEMIOL, V38, P1245, DOI 10.1093/ije/dyp260
   O'Leary C. M., 2012, DEV MED CHILD NEUROL, V55
   O'Brien J, 2001, AUST J SOC ISSUES, V36, P51
   O'Donnell M, 2010, INT J EPIDEMIOL, V39, P921, DOI 10.1093/ije/dyq005
   O'Leary CM, 2012, DEV MED CHILD NEUROL, V54, P224, DOI 10.1111/j.1469-8749.2011.04201.x
   PALMER L, 1995, PAEDIATR PERINAT EP, V9, P171, DOI 10.1111/j.1365-3016.1995.tb00132.x
   Petterson B, 2007, PAEDIATR PERINAT EP, V21, P65, DOI 10.1111/j.1365-3016.2007.00774.x
   PETTERSON B, 1993, BRIT MED J, V307, P1239
   Petterson B, 2005, ANN HUM BIOL, V32, P237, DOI 10.1080/03014460500075035
   Pinborg A, 2010, FERTIL STERIL, V94, P1320, DOI 10.1016/j.fertnstert.2009.05.091
   Ponjaert-Kristoffersen I, 2004, HUM REPROD, V19, P2791, DOI 10.1093/humrep/deh511
   Rabe-Hesketh S, 2008, MULTILEVEL LONGITUDI
   Raudenbush S. W., 2002, HIERARCHICAL LINEAR, V2nd
   Sanchez-Albisua I, 2007, DEV MED CHILD NEUROL, V49, P129
   Singer S, 1999, AM J MED GENET, V83, P382, DOI 10.1002/(SICI)1096-8628(19990423)83:5<382::AID-AJMG8>3.0.CO;2-A
   So SA, 2007, J INTELL DISABIL RES, V51, P1030, DOI 10.1111/j.1365-2788.2007.01013.x
   STANLEY FJ, 1994, PAEDIATR PERINAT EP, V8, P433, DOI 10.1111/j.1365-3016.1994.tb00482.x
   STANLEY FJ, 1993, DEV MED CHILD NEUROL, V35, P191
   Steinhausen HC, 1998, ALCOHOL CLIN EXP RES, V22, P334, DOI 10.1111/j.1530-0277.1998.tb03657.x
   Sullivan PM, 2000, CHILD ABUSE NEGLECT, V24, P1257, DOI 10.1016/S0145-2134(00)00190-3
   Sullivan PM, 1998, CHILD ABUSE NEGLECT, V22, P271, DOI 10.1016/S0145-2134(97)00175-0
   Sutcliffe AG, 2001, LANCET, V357, P2080, DOI 10.1016/S0140-6736(00)05180-1
   Thomas K, 2011, J PEDIATR-US, V158, P194, DOI 10.1016/j.jpeds.2010.08.045
   Urbanowicz A, 2011, RES AUTISM SPECT DIS, V5, P722, DOI 10.1016/j.rasd.2010.08.006
   Lantman-de Valk HMJV, 2005, J APPL RES INTELLECT, V18, P325, DOI 10.1111/j.1468-3148.2005.00265.x
   Watson L, 2006, REPORT W AUSTR CEREB
   Westat Inc, 1993, REP MALTR CHILDR DIS
   WHITE H, 1980, ECONOMETRICA, V48, P817, DOI 10.2307/1912934
   Williams RL, 2000, BIOMETRICS, V56, P645, DOI 10.1111/j.0006-341X.2000.00645.x
   YearginAllsopp M, 1997, DEV MED CHILD NEUROL, V39, P142
NR 103
TC 2
Z9 2
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-407760-7
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 45
BP 281
EP 327
DI 10.1016/B978-0-12-407760-7.00008-6
PG 47
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BJN47
UT WOS:000329255200009
ER

PT S
AU Urbano, RC
AF Urbano, Richard C.
BE Urbano, RC
TI Large-Scale Datasets Referenced in Volume 45 of the International Review
   of Research in Developmental Disabilities
SO USING SECONDARY DATASETS TO UNDERSTAND PERSONS WITH DEVELOPMENTAL
   DISABILITIES AND THEIR FAMILIES
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID SPECIAL-EDUCATION; DOWN-SYNDROME; PREDICTORS; CHILDREN; AUTISM
AB This chapter characterizes over 20 datasets referenced in this volume and reviews recurring themes across this volume. Six themes addressed by one or more authors are presented: coverage (variables measured and ages of subjects), definition of intellectual disabilities/developmental disabilities (ID/DD) (variables used to identify type of ID/DD and individuals affected), missing variables (information not recorded or reported), missing data (values not reported on existing variables), data harmonization (consistent definition and coding of variables across datasets), and-sample characteristics (sampling biases and subject selection). In addition, two tables summarize selected characteristics of each dataset: abbreviated dataset name, age range, measurement domains, countries of data collection, representative publications, complete dataset name, and home page Web address.
C1 Vanderbilt Univ, Sch Med, Vanderbilt Kennedy Ctr, Dept Pediat Dev Med, Nashville, TN 37212 USA.
RP Urbano, RC (reprint author), Vanderbilt Univ, Sch Med, Vanderbilt Kennedy Ctr, Dept Pediat Dev Med, Nashville, TN 37212 USA.
EM richard.urbano@vanderbilt.edu
CR Bailey DB, 2010, AJIDD-AM J INTELLECT, V115, P447, DOI [10.1352/1944-7558-115.6.447, 10.1352/194475581156447]
   Bailey DB, 2004, PEDIATRICS, V113, P887, DOI 10.1542/peds.113.4.887
   Bebbington A., 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2012-002356
   Bilder DA, 2013, AJIDD-AM J INTELLECT, V118, P156, DOI 10.1352/1944-7558-118.2.156
   Buckley J. A., 2007, 2007005 NCES
   Daley TC, 2009, EXCEPT CHILDREN, V75, P412
   Feinberg E, 2011, J DEV BEHAV PEDIATR, V32, P284, DOI 10.1097/DBP.0b013e3182142fbd
   Glasson EJ, 2008, INT J EPIDEMIOL, V37, P30, DOI 10.1093/ije/dym136
   Graham DJ, 2005, LANCET, V365, P475, DOI 10.1016/S0140-6736(05)17864-7
   Griffin M. M., 2013, J SPECIAL ED
   Griffin M. M, 2013, INT REV RES MENT RET, V45, P135
   Hall D, 2012, NEUROINFORMATICS, V10, P331, DOI 10.1007/s12021-012-9151-4
   Hibel J, 2010, SOCIOL EDUC, V83, P312, DOI 10.1177/0038040710383518
   Hodapp RM, 2010, INTELLECT DEV DISAB, V48, P52, DOI 10.1352/1934-9556-48.1.52
   Holman CDJ, 2008, AUST HEALTH REV, V32, P766
   Kalb LG, 2012, J AM MED INFORM ASSN, V19, P668, DOI 10.1136/amiajnl-2012-000863
   Leonard H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017875
   McCallion P., 2009, SAGE HDB SOCIAL WORK
   Nageswaran S, 2011, MATERN CHILD HLTH J, V15, P634, DOI 10.1007/s10995-010-0597-4
   Newman L., 2010, COMPARISONS TIME OUT
   Park G., 2013, FINANCIAL ED CAPABIL
   Richman DM, 2013, J INTELL DISABIL RES, V57, P429, DOI 10.1111/j.1365-2788.2012.01628.x
   Seltzer MM, 2005, AM J MENT RETARD, V110, P451, DOI 10.1352/0895-8017(2005)110[451:LCIOMI]2.0.CO;2
   Supekar K., 2013, 2013 INT M IN PRESS
   Uddin LQ, 2013, JAMA PSYCHIAT, V70, P869, DOI 10.1001/jamapsychiatry.2013.104
   Urbano RC, 2007, AM J MENT RETARD, V112, P261, DOI 10.1352/0895-8017(2007)112[261:DIFOCW]2.0.CO;2
   Wagner M., 2004, OVERVIEW FINDINGS WA
   Woythaler MA, 2011, PEDIATRICS, V127, pE622, DOI 10.1542/peds.2009-3598
   Zhu JL, 2013, AM J MED GENET A, V161A, P650, DOI 10.1002/ajmg.a.35711
NR 29
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-407760-7
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 45
BP 329
EP 342
DI 10.1016/B978-0-12-407760-7.00009-8
PG 14
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BJN47
UT WOS:000329255200010
ER

PT J
AU Sforza, C
   de Menezes, M
   Ferrario, VF
AF Sforza, Chiarella
   de Menezes, Marcio
   Ferrario, Virgilio F.
TI Soft- and hard-tissue facial anthropometry in three dimensions: what's
   new
SO JOURNAL OF ANTHROPOLOGICAL SCIENCES
LA English
DT Review
DE Human face; Morphometrics; 3D analysis
ID BEAM COMPUTED-TOMOGRAPHY; UNILATERAL CLEFT-LIP; AUTISM SPECTRUM
   DISORDERS; NORTH SUDANESE SUBJECTS; AGE-RELATED-CHANGES; 3-DIMENSIONAL
   ANALYSIS; DOWN-SYNDROME; GEOMETRIC MORPHOMETRICS; SEXUAL-DIMORPHISM;
   HUMAN FACE
AB In the last few years, technology has provided new instruments for the three-dimensional analysis of human facial morphology. Currently, quantitative assessments of dimensions, spatial positions and relative proportions of distinctive facial features can be obtained for both soft-and hard- (skeletal and dental) tissues. New mathematical tools allow to fuse digital data obtained from various image analyzers, thus providing quantitative information for anatomical and anthropometric descriptions, medical evaluations (clinical genetics, orthodontics, maxillo-facial and plastic surgery), and forensic medicine.
C1 [Sforza, Chiarella; Ferrario, Virgilio F.] Univ Milan, LAFAS, FARC, Dipartimento Sci Biomed Salute,Fac Med & Chirurg, I-20122 Milan, Italy.
   [de Menezes, Marcio] Univ Fed Rio Grande do Sul, Dept Prevent & Social Dent, BR-90046900 Porto Alegre, RS, Brazil.
   [de Menezes, Marcio] State Univ Amazonas, Sch Hlth Sci, Manaus, Amazonas, Brazil.
RP Sforza, C (reprint author), Univ Milan, LAFAS, FARC, Dipartimento Sci Biomed Salute,Fac Med & Chirurg, I-20122 Milan, Italy.
EM chiarella.sforza@unimi.it
CR Abed Y, 2009, ANGLE ORTHOD, V79, P235, DOI 10.2319/030608-133.1
   Abel RL, 2011, COMPUT GRAPH-UK, V35, P878, DOI 10.1016/j.cag.2011.03.001
   Aboul-Hosn Centenero S, 2012, J CRANIOMAXILLOFAC S, V40, P162
   Adams GL, 2004, AM J ORTHOD DENTOFAC, V126, P397, DOI 10.1016/j.ajodo.2004.03.023
   Aeria G, 2010, FORENSIC SCI INT, V201, P118, DOI 10.1016/j.forsciint.2010.03.005
   Aldridge K, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-15
   Aldridge K, 2005, AM J MED GENET A, V138A, P247, DOI 10.1002/ajmg.a.30959
   Allanson JE, 2011, AM J MED GENET A, V155A, P1563, DOI 10.1002/ajmg.a.34027
   Arca S, 2012, J FORENSIC SCI, V57, P765, DOI 10.1111/j.1556-4029.2011.02018.x
   Aynechi N, 2011, ANGLE ORTHOD, V81, P245, DOI 10.2319/041810-210.1
   Badawi-Fayad J, 2007, ANAT REC, V290, P268, DOI 10.1002/ar.20442
   Baik HS, 2010, AM J ORTHOD DENTOFAC, V138, P167, DOI 10.1016/j.ajodo.2010.02.022
   Baynam G, 2011, TWIN RES HUM GENET, V14, P305, DOI 10.1375/twin.14.4.305
   Bechtold TE, 2012, J OROFAC ORTHOP, V73, P126, DOI 10.1007/s00056-011-0060-1
   Berneburg M, 2012, ORTHOD CRANIOFAC RES, V15, P103
   Bigoni L, 2010, HOMO, V61, P16, DOI 10.1016/j.jchb.2009.09.004
   Binelli M., 2010, FORENSIC SCI INT, V200
   Bock MT, 2006, J ROY STAT SOC C-APP, V55, P77, DOI 10.1111/j.1467-9876.2005.00532.x
   Boehringer S, 2011, EUR J HUM GENET, V19, P1192, DOI 10.1038/ejhg.2011.110
   Bottino A, 2012, IEEE T BIO-MED ENG, V59, P3439, DOI 10.1109/TBME.2012.2217496
   Boulanger P, 2009, IEEE ENG MED BIO, P3525, DOI 10.1109/IEMBS.2009.5334718
   Breitsprecher L, 1999, ANN ANAT, V181, P19, DOI 10.1016/S0940-9602(99)80080-6
   Buck U, 2011, INT J LEGAL MED, V125, P785, DOI 10.1007/s00414-010-0518-5
   Cadoni M., 2010, 18 EUR SIGN PROC C E, V23-27, P1670
   Calignano F, 2011, AESTHET PLAST SURG, V35, P289, DOI 10.1007/s00266-010-9579-6
   Cattaneo C, 2009, FORENSIC SCI INT, V183, pE21, DOI 10.1016/j.forsciint.2008.09.005
   Cattaneo C, 2012, INT J LEGAL MED, V126, P139, DOI 10.1007/s00414-011-0564-7
   Cevidanes LHC, 2010, AM J ORTHOD DENTOFAC, V137, pS120, DOI 10.1016/j.ajodo.2009.04.021
   Chakravarty MM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020241
   CLAES P, 2012, THEOR BIOL MED MODEL, V9, P1
   Claes P, 2011, J ANAT, V219, P444, DOI 10.1111/j.1469-7580.2011.01411.x
   Claes P, 2012, J ANAT, V221, P97, DOI 10.1111/j.1469-7580.2012.01528.x
   De Greef S, 2006, FORENSIC SCI INT, V159, pS126, DOI 10.1016/j.forsciint.2006.02.034
   Claes P, 2010, FORENSIC SCI INT, V201, P138, DOI 10.1016/j.forsciint.2010.03.008
   Claes P, 2012, INT J ORAL MAX SURG, V41, P324, DOI 10.1016/j.ijom.2011.10.019
   Damstra J, 2011, AM J ORTHOD DENTOFAC, V140, P886, DOI 10.1016/j.ajodo.2010.03.032
   Deli R, 2010, J CRANIOFAC SURG, V21, P87, DOI 10.1097/SCS.0b013e3181c3ba74
   Deli R, 2011, J CRANIOFAC SURG, V22, P54, DOI 10.1097/SCS.0b013e3181f6c4a1
   Dellavia C, 2008, EUR J ORAL SCI, V116, P305, DOI 10.1111/j.1600-0722.2008.00550.x
   Dellavia C, 2010, ANGLE ORTHOD, V80, P733, DOI 10.2319/101909-584.1
   de Menezes M, 2010, J ORAL MAXIL SURG, V68, P2129, DOI 10.1016/j.joms.2009.09.036
   De Menezes M, 2011, INT J ORAL MAX SURG, V40, P856, DOI 10.1016/j.ijom.2011.03.004
   de Menezes M, 2009, ANGLE ORTHOD, V79, P1070, DOI [10.2319/111008-570, 10.2319/111008-570.1]
   Deo D, 2010, J COMPUT INF SCI ENG, V10, DOI 10.1115/1.3330420
   Desai S., 2009, AM J ORTHOD DENTOFAC, V136
   Dimaggio FR, 2007, AM J ORTHOD DENTOFAC, V132, P475, DOI 10.1016/j.ajodo.2005.10.029
   Dirven R, 2008, ACTA OTO-LARYNGOL, V128, P1248, DOI 10.1080/00016480801901717
   Dong Y, 2010, J PLAST RECONSTR AES, V63, P1832, DOI 10.1016/j.bjps.2009.11.035
   Douglas TS, 2010, AM J MED GENET A, V152A, P528, DOI 10.1002/ajmg.a.33276
   Driessen JP, 2011, INT J PEDIATR OTORHI, V75, P579, DOI 10.1016/j.ijporl.2011.01.023
   Elton S, 2008, J ANTHROPOL SCI, V86, P209
   English J. D., 2010, AM J ORTHOD DENTOFAC, V137, p[S56, e51]
   Evison M, 2010, J FORENSIC SCI, V55, P159, DOI 10.1111/j.1556-4029.2009.01213.x
   Fang F, 2011, PLAST RECONSTR SURG, V127, P874, DOI 10.1097/PRS.0b013e318200afdb
   Fang SY, 2011, COMPUT AIDED DESIGN, V43, P1729, DOI 10.1016/j.cad.2011.06.014
   Ferrario V. F., 2007, EUR J HISTOCHEM S1, V51, P45
   Ferrario VF, 2009, J ORAL MAXIL SURG, V67, P1832, DOI 10.1016/j.joms.2009.04.080
   Fourie Z, 2012, EUR J RADIOL, V81, pE524, DOI 10.1016/j.ejrad.2011.06.001
   Fourie Z, 2011, FORENSIC SCI INT, V207, P127, DOI 10.1016/j.forsciint.2010.09.018
   Fourie Z, 2011, CLEFT PALATE-CRAN J, V48, P623, DOI 10.1597/10-076
   Friess M, 2012, J ANTHROPOL SCI, V90, P7, DOI 10.4436/jass.90004
   Garvin HM, 2012, AM J PHYS ANTHROPOL, V147, P661, DOI 10.1002/ajpa.22036
   Germec-Cakan D, 2010, J CRANIOFAC SURG, V21, P1393, DOI 10.1097/SCS.0b013e3181ec6976
   Ghoddousi H, 2007, INT J ORAL MAX SURG, V36, P250, DOI 10.1016/j.ijom.2006.10.001
   Gor T, 2010, AM J ORTHOD DENTOFAC, V137, P424, DOI 10.1016/j.ajodo.2008.12.022
   Gupta S, 2010, INT J COMPUT VISION, V90, P331, DOI 10.1007/s11263-010-0360-8
   Gwilliam JR, 2006, EUR J ORTHODONT, V28, P408, DOI 10.1093/ejo/cjl024
   Hajeer M Y, 2004, J Orthod, V31, P62, DOI 10.1179/146531204225011346
   Hammond P, 2012, HUM MUTAT, V33, P817, DOI 10.1002/humu.22054
   Hammond P, 2008, MOL PSYCHIATR, V13, P614, DOI 10.1038/mp.2008.18
   Han K, 2010, J CRANIO MAXILL SURG, V38, P96, DOI 10.1016/j.jcms.2009.04.003
   Harrison JA, 2004, BRIT J ORAL MAX SURG, V42, P8, DOI 10.1016/S0266-4356(03)00192-X
   Heike CL, 2010, HEAD FACE MED, V6, DOI 10.1186/1746-160X-6-18
   Hennessy RJ, 2005, J ANAT, V207, P283, DOI 10.1111/j.1469-7580.2005.00444.x
   Herrmann F. R., 2010, AM J ORTHOD DENTOFAC, V137
   Hwang HS, 2012, J FORENSIC SCI, V57, P443, DOI 10.1111/j.1556-4029.2011.02007.x
   Iblher N, 2008, J PLAST RECONSTR AES, V61, P1170, DOI 10.1016/j.bjps.2008.06.001
   Incrapera AK, 2010, ANGLE ORTHOD, V80, P58, DOI 10.2319/111408-583.1
   Jalil MA, 2012, INT J NANOMED, V7, P773, DOI 10.2147/IJN.S27625
   Ji YR, 2010, J ANAT, V217, P501, DOI 10.1111/j.1469-7580.2010.01286.x
   Joe PS, 2012, J OCCUP ENVIRON HYG, V9, P81, DOI 10.1080/15459624.2011.640557
   Katsumata A, 2005, ORAL SURG ORAL MED O, V99, P212, DOI 10.1016/j.tripleo.2004.06.072
   Kau CH, 2006, J ORAL MAXIL SURG, V64, P1086, DOI 10.1016/j.joms.2006.03.013
   Keller SS, 2009, J ANTHROPOL SCI, V87, P127
   Kimoto K, 2007, J ORAL REHABIL, V34, P201, DOI 10.1111/j.1365-2842.2006.01663.x
   Kochel J., 2010, J OROFAC ORTHOP, V71, P40
   Kovacs L, 2006, J PLAST RECONSTR AES, V59, P1193, DOI 10.1016/j.bjps.2005.10.025
   Kullmer O, 2008, J ANTHROPOL SCI, V86, P205
   Lee WJ, 2012, J FORENSIC SCI, V57, P318, DOI 10.1111/j.1556-4029.2011.01971.x
   Li SZ, 2007, IEEE T PATTERN ANAL, V29, P627, DOI 10.1109/TPAMI.2007.1014
   Lubbers HT, 2012, BRIT J ORAL MAX SURG, V50, P171, DOI 10.1016/j.bjoms.2010.12.002
   Lynch M., 2000, GEOGRAPHERS CRAFT PR
   Maal TJJ, 2010, J ORAL MAXIL SURG, V68, P2391, DOI 10.1016/j.joms.2009.10.017
   Maal TJJ, 2008, INT J ORAL MAX SURG, V37, P641, DOI 10.1016/j.ijom.2008.04.012
   Maal TJJ, 2011, INT J ORAL MAX SURG, V40, P1252, DOI 10.1016/j.ijom.2011.02.033
   Mallett XDG, 2010, J FORENSIC SCI, V55, P1025, DOI 10.1111/j.1556-4029.2010.01425.x
   Maravelakis E., 2011, ANGLE ORTHOD, V81, P169
   McGhee J, 2010, J ANAT, V216, P264, DOI 10.1111/j.1469-7580.2009.01165.x
   Mehta RP, 2008, OTOLARYNG HEAD NECK, V138, P468, DOI 10.1016/j.otohns.2007.12.017
   Merchan P, 2011, SENSORS-BASEL, V11, P8497, DOI 10.3390/s110908497
   Moro A, 2009, J CRANIOFAC SURG, V20, P417, DOI 10.1097/SCS.0b013e31819b96a5
   Mutsvangwa T. E., 2010, AM J MED GENET A, V152A, P32
   Mutsvangwa TEM, 2011, ANN ANAT, V193, P100, DOI 10.1016/j.aanat.2010.10.008
   Nakasima A, 2005, AM J ORTHOD DENTOFAC, V127, P282, DOI 10.1016/j.ajodo.2003.11.030
   Papadopoulos MA, 2002, ORAL SURG ORAL MED O, V93, P382, DOI 10.1067/moe.2002.121385
   Pellegrini A, 2011, J ANTHROPOL SCI, V89, P139, DOI 10.4436/jass.89013
   Penna V, 2009, PLAST RECONSTR SURG, V124, P624, DOI 10.1097/PRS.0b013e3181addc06
   Popat H, 2010, OTOLARYNG HEAD NECK, V142, P867, DOI 10.1016/j.otohns.2010.03.003
   Primozic J, 2009, EUR J ORTHODONT, V31, P352, DOI 10.1093/ejo/cjp041
   Ramieri GA, 2006, DENTOMAXILLOFAC RAD, V35, P158, DOI 10.1259/dmfr/43516583
   Ramieri GA, 2008, INT J ORAL MAX SURG, V37, P810, DOI 10.1016/j.ijom.2008.05.006
   Rangel FA, 2008, AM J ORTHOD DENTOFAC, V134, P820, DOI 10.1016/j.ajodo.2007.11.026
   Ritz-Timme S., 2011, FORENSIC SCI INT, V207
   Rosati R, 2012, INT J ORAL MAX SURG, V41, P1344, DOI 10.1016/j.ijom.2012.04.002
   Rosati R, 2010, AM J ORTHOD DENTOFAC, V138, P84, DOI 10.1016/j.ajodo.2009.10.035
   Rosati R, 2012, INT J ORAL SCI, V4, P34, DOI 10.1038/ijos.2012.2
   Sawyer AR, 2009, AESTHET PLAST SURG, V33, P497, DOI 10.1007/s00266-008-9191-1
   Sawyer AR, 2009, OTOLARYNG HEAD NECK, V140, P76, DOI 10.1016/j.otohns.2008.09.007
   Schaaf H, 2010, NEUROPEDIATRICS, V41, P24, DOI 10.1055/s-0030-1255060
   Schwenzer-Zimmerer K, 2008, J CRANIO MAXILL SURG, V36, P431, DOI 10.1016/j.jcms.2008.05.003
   See M. S., 2007, EUR J PLAST SURG, V29, P387
   See MS, 2008, J ORAL MAXIL SURG, V66, P1410, DOI 10.1016/j.joms.2007.12.041
   Seeberger R, 2012, J CRANIO MAXILL SURG, V40, P156, DOI 10.1016/j.jcms.2011.03.003
   Sforza C, 2011, J CRANIOFAC SURG, V22, P297, DOI 10.1097/SCS.0b013e3181f7dd8c
   Sforza C, 2009, ANGLE ORTHOD, V79, P17, DOI 10.2319/122707-605.1
   SFORZA C, 2011, FORENSIC SCI INT, V204
   Sforza C, 2008, ANGLE ORTHOD, V78, P799, DOI 10.2319/091207-431.1
   Sforza C., 2009, FORENSIC SCI INT, V185
   Sforza C, 2010, SYMMETRY-BASEL, V2, P1925, DOI 10.3390/sym2041925
   Sforza C, 2012, J CRANIO MAXILL SURG, V40, P473, DOI 10.1016/j.jcms.2011.07.004
   Sforza C, 2011, ANGLE ORTHOD, V81, P107, DOI 10.2319/042510-222.1
   Sforza C, 2012, CLEFT PALATE-CRAN J, V49, P477, DOI 10.1597/10-207
   Sforza C, 2010, INT J ORAL MAX SURG, V39, P990, DOI 10.1016/j.ijom.2010.05.011
   Sforza C, 2007, ANGLE ORTHOD, V77, P1025, DOI 10.2319/100206-400.1
   Sforza C., 2009, FORENSIC SCI INT, V187
   Sforza C, 2009, EUR J ORAL SCI, V117, P695, DOI 10.1111/j.1600-0722.2009.00685.x
   Sforza C, 2012, J CRANIOFAC SURG, V23, P198, DOI 10.1097/SCS.0b013e3182418eba
   Sforza C, 2012, INT J ORAL MAX SURG, V41, P986, DOI 10.1016/j.ijom.2012.02.019
   Sforza Chiarella, 2010, Italian Journal of Anatomy and Embryology, V115, P141
   SFORZA C, 2006, J ANTHROPOL SCI, V84, P97
   Sforza C, 2010, J CRANIO MAXILL SURG, V38, P409, DOI 10.1016/j.jcms.2009.10.018
   Shearer B. M., 2012, FORENSIC SCI INT, V10
   Simanca E, 2011, J CRANIOFAC SURG, V22, P1622, DOI 10.1097/SCS.0b013e31822e8ca0
   Sisk M. L., 2010, FIN INT C GIG IM SCI
   Smeets D, 2010, FORENSIC SCI INT, V201, P125, DOI 10.1016/j.forsciint.2010.03.023
   Starbuck J, 2011, AM J PHYS ANTHROPOL, V146, P560, DOI 10.1002/ajpa.21583
   Sumner TA, 2009, J ANTHROPOL SCI, V87, P219
   Swennen GRJ, 2009, J ORAL MAXIL SURG, V67, P2080, DOI 10.1016/j.joms.2009.06.007
   Tartaglia GM, 2009, J APPL ORAL SCI, V17, P487, DOI 10.1590/S1678-77572009000500025
   Tollefson TT, 2007, ARCH FACIAL PLAST S, V9, P113, DOI 10.1001/archfaci.9.2.113
   Trotman CA, 2011, AM J ORTHOD DENTOFAC, V140, P895, DOI 10.1016/j.ajodo.2011.07.014
   Van der Geld P, 2008, EUR J ORTHODONT, V30, P366, DOI 10.1093/ejo/cjn009
   van Loon B, 2010, INT J ORAL MAX SURG, V39, P534, DOI 10.1016/j.ijom.2010.03.022
   Verze L, 2011, J CRANIOFAC SURG, V22, P2304, DOI 10.1097/SCS.0b013e318232a7f0
   Verze L, 2011, J CRANIOFAC SURG, V22, P60, DOI 10.1097/SCS.0b013e3181f6c46d
   Vezzetti E, 2010, J PLAST RECONSTR AES, V63, P218, DOI 10.1016/j.bjps.2008.09.031
   Walters M, 2013, INT J ORAL MAX SURG, V42, P36, DOI 10.1016/j.ijom.2012.05.021
   Wang B, 2011, J PLAST RECONSTR AES, V64, P34, DOI 10.1016/j.bjps.2010.03.053
   Weinberg SM, 2009, ORTHOD CRANIOFAC RES, V12, P271, DOI 10.1111/j.1601-6343.2009.01462.x
   Weinberg SM, 2004, CLEFT PALATE-CRAN J, V41, P507, DOI 10.1597/03-066.1
   Wilkinson C, 2010, J ANAT, V216, P235, DOI 10.1111/j.1469-7580.2009.01182.x
   Zhuang ZQ, 2010, ANN OCCUP HYG, V54, P391, DOI 10.1093/annhyg/meq007
   Zhuang ZQ, 2010, ERGONOMICS, V53, P661, DOI 10.1080/00140130903581656
   Zreaqat M, 2012, INT J ORAL MAX SURG, V41, P783, DOI 10.1016/j.ijom.2012.02.003
NR 164
TC 4
Z9 5
PU IST ITALIANO ANTROPOLOGIA
PI ROMA
PA UNIV SAPIENZA, DIPARTIMENTO DI BIOLOGIA ANIMALE E DELL UOMO, PE LE A
   MORO 5, ROMA, 00185, ITALY
SN 1827-4765
EI 2037-0644
J9 J ANTHROPOL SCI
JI J. Anthropol. Sci.
PY 2013
VL 91
BP 159
EP 184
DI 10.4436/JASS.91007
PG 26
WC Anthropology
SC Anthropology
GA 278KW
UT WOS:000328890200008
PM 23833019
ER

PT J
AU Ciccoli, L
   De Felice, C
   Paccagnini, E
   Leoncini, S
   Pecorelli, A
   Signorini, C
   Belmonte, G
   Guerranti, R
   Cortelazzo, A
   Gentile, M
   Zollo, G
   Durand, T
   Valacchi, G
   Rossi, M
   Hayek, J
AF Ciccoli, Lucia
   De Felice, Claudio
   Paccagnini, Eugenio
   Leoncini, Silvia
   Pecorelli, Alessandra
   Signorini, Cinzia
   Belmonte, Giuseppe
   Guerranti, Roberto
   Cortelazzo, Alessio
   Gentile, Mariangela
   Zollo, Gloria
   Durand, Thierry
   Valacchi, Giuseppe
   Rossi, Marcello
   Hayek, Joussef
TI Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and
   beta-Actin Alterations: An Unrecognized Triad in Classical Autism
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID RETT-SYNDROME; SPECTRUM DISORDERS; LIPID-PEROXIDATION; STRESS; BLOOD;
   IRON; CELL; CHILDREN; REGION; BRAIN
AB Autism spectrum disorders (ASDs) are a complex group of neurodevelopment disorders steadily rising in frequency and treatment refractory, where the search for biological markers is of paramount importance. Although red blood cells (RBCs) membrane lipidomics and rheological variables have been reported to be altered, with some suggestions indicating an increased lipid peroxidation in the erythrocyte membrane, to date no information exists on how the oxidative membrane damage may affect cytoskeletal membrane proteins and, ultimately, RBCs shape in autism. Here, we investigated RBC morphology by scanning electron microscopy in patients with classical autism, that is, the predominant ASDs phenotype (age range: 6-26 years), nonautistic neurodevelopmental disorders (i.e., "positive controls"), and healthy controls (i.e., "negative controls"). A high percentage of altered RBCs shapes, predominantly elliptocytes, was observed in autistic patients, but not in both control groups. The RBCs altered morphology in autistic subjects was related to increased erythrocyte membrane F-2-isoprostanes and 4-hydroxynonenal protein adducts. In addition, an oxidative damage of the erythrocyte membrane beta-actin protein was evidenced. Therefore, the combination of erythrocyte shape abnormalities, erythrocyte membrane oxidative damage, and beta-actin alterations constitutes a previously unrecognized triad in classical autism and provides new biological markers in the diagnostic workup of ASDs.
C1 [Ciccoli, Lucia; Leoncini, Silvia; Pecorelli, Alessandra; Signorini, Cinzia; Zollo, Gloria] Univ Siena, Dept Mol & Dev Med, I-53100 Siena, Italy.
   [De Felice, Claudio] Univ Hosp, AOUS, Neonatal Intens Care Unit, I-53100 Siena, Italy.
   [Paccagnini, Eugenio] Univ Siena, Dept Life Sci, I-53100 Siena, Italy.
   [Leoncini, Silvia; Pecorelli, Alessandra; Cortelazzo, Alessio; Zollo, Gloria; Hayek, Joussef] Univ Hosp, Child Neuropsychiat Unit, I-53100 Siena, Italy.
   [Belmonte, Giuseppe] Univ Hosp, Med Surg & Neurosci Dept, I-53100 Siena, Italy.
   [Guerranti, Roberto] Univ Hosp, AOUS, Clin Pathol Lab Unit, I-53100 Siena, Italy.
   [Guerranti, Roberto; Cortelazzo, Alessio] Univ Siena, Dept Med Biotechnol, I-53100 Siena, Italy.
   [Durand, Thierry] UM1, UM2, CNRS, IBMM,UMR 5247, F-34093 Montpellier 5, France.
   [Valacchi, Giuseppe] Univ Ferrara, I-44100 Ferrara, Italy.
   [Valacchi, Giuseppe] Kyung Hee Univ, Dept Food & Nutr, Seoul 130701, South Korea.
   [Rossi, Marcello] Univ Hosp, AOUS, Resp Pathophysiol & Rehabil Unit, I-53100 Siena, Italy.
RP De Felice, C (reprint author), Univ Hosp, AOUS, Neonatal Intens Care Unit, Viale M Bracci 16, I-53100 Siena, Italy.
EM geniente@gmail.com
FU Tuscany Region (Bando Salute, "Antioxidants (-3 Polyunsaturated Fatty
   Acids, lipoic acid) supplementation in Rett syndrome: A novel approach
   to therapy"), Italy
FX The present research project has been funded by the Tuscany Region
   (Bando Salute 2009, "Antioxidants (omega-3 Polyunsaturated Fatty Acids,
   lipoic acid) supplementation in Rett syndrome: A novel approach to
   therapy"), Italy. The authors sincerely thank Drs. Pierluigi Tosi,
   Silvia Briani, and Roberta Croci from the Administrative Direction of
   the Azienda Ospedaliera Senese for continued support to their studies
   and the Azienda Ospedaliera Senese for prior purchasing of the gas
   spectrometry instrumentation. We thank Roberto Faleri (Central Medical
   Library, University of Siena, Siena, Italy) for online bibliographic
   assistance. The authors sincerely thank the professional singer Matteo
   Setti (http://www.matteosetti.com/) for having serendipitously triggered
   the scientific studies on hypoxia-related oxidative stress in Rett girls
   and autistic children, as well as his many charity concerts and
   continued interest and support in the scientific aspects of our
   research.
CR An XL, 2005, BIOCHEMISTRY-US, V44, P10681, DOI 10.1021/bi047331z
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
   Barcellini W, 2011, BLOOD TRANSFUS-ITALY, V9, P274, DOI 10.2450/2011.0086-10
   Bessis M., 1977, REINTERPRETATION FRO
   Brown CM, 2011, PROSTAG LEUKOTR ESS, V84, P25, DOI 10.1016/j.plefa.2010.09.007
   Chahrour M, 2007, NEURON, V56, P422, DOI 10.1016/j.neuron.2007.10.001
   Chauhan A, 2012, NEUROCHEM RES, V37, P1681, DOI 10.1007/s11064-012-0775-4
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Cheever TR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017768
   Cheever TR, 2013, INT REV CEL MOL BIO, V301, P157, DOI 10.1016/B978-0-12-407704-1.00004-X
   CHIEN S, 1987, ANNU REV PHYSIOL, V49, P177, DOI 10.1146/annurev.ph.49.030187.001141
   Ciccoli Lucia, 2008, P167, DOI 10.1007/978-1-4020-8399-0_8
   Ciccoli L, 2012, BBA-GEN SUBJECTS, V1820, P511, DOI 10.1016/j.bbagen.2011.12.002
   Ciccoli L., 1999, Toxicology Letters (Shannon), V110, P57, DOI 10.1016/S0378-4274(99)00138-1
   CICCOLI L, 1994, EXP MOL PATHOL, V60, P108, DOI 10.1006/exmp.1994.1010
   De Felice C, 2012, ANN NY ACAD SCI, V1259, P121, DOI 10.1111/j.1749-6632.2012.06611.x
   De Felice C, 2009, FREE RADICAL BIO MED, V47, P440, DOI 10.1016/j.freeradbiomed.2009.05.016
   DODGE JT, 1963, ARCH BIOCHEM BIOPHYS, V100, P119, DOI 10.1016/0003-9861(63)90042-0
   Dubinina EE, 2010, BIOCHEMISTRY-MOSCOW+, V75, P1069, DOI 10.1134/S0006297910090014
   Fombonne E, 2001, PEDIATRICS, V107, P411, DOI 10.1542/peds.107.2.411
   Frustaci, 2012, FREE RADICAL BIO MED, V52, P2128
   Gallagher P. G., 2009, HEMATOLOGY BASIC PRI, P623
   Ghezzo A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066418
   Grillo E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056599
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   Herguner S, 2012, EUR J PEDIATR, V171, P143, DOI 10.1007/s00431-011-1506-6
   James SJ, 2004, AM J CLIN NUTR, V80, P1611
   Kumar V, 2010, ROBBINS COTRAN PATHO
   LAEMMLI UK, 1970, NATURE, V227, P680, DOI 10.1038/227680a0
   Laszlo A, 2013, IDEGGYOGY SZEMLE, V66, P23
   Leoncini S, 2011, REDOX REP, V16, P145, DOI 10.1179/1351000211Y.0000000004
   Lucantoni G, 2006, ANTIOXID REDOX SIGN, V8, P1171, DOI 10.1089/ars.2006.8.1171
   Miyake K, 2012, ADV EXP MED BIOL, V724, P91, DOI 10.1007/978-1-4614-0653-2_7
   Naviaux RK, 2012, J PHARMACOL EXP THER, V342, P608, DOI 10.1124/jpet.112.192120
   Nunomura W, 2006, FRONT BIOSCI, V11, P1522, DOI 10.2741/1901
   Palmieri L, 2010, BBA-BIOENERGETICS, V1797, P1130, DOI 10.1016/j.bbabio.2010.04.018
   Pecorelli A, 2011, CLIN BIOCHEM, V44, P368, DOI 10.1016/j.clinbiochem.2011.01.007
   Pecorelli A, 2013, BRAIN DEV-JPN, V35, P146, DOI 10.1016/j.braindev.2012.03.011
   Prohaska R, 2012, NEUROBIOL DIS, V46, P607, DOI 10.1016/j.nbd.2012.03.006
   Rocha S, 2005, EUR J HAEMATOL, V74, P374, DOI 10.1111/j.1600-0609.2004.00385.x
   Sajdel-Sulkowska EM, 2011, CEREBELLUM, V10, P43, DOI 10.1007/s12311-010-0223-4
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Signorini C, 2011, CLIN CHIM ACTA, V412, P1399, DOI 10.1016/j.cca.2011.04.016
   Srour MA, 2000, CLIN HEMORHEOL MICRO, V23, P13
   Testa C, 2012, ASN NEURO, V4, P223, DOI 10.1042/AN20120015
   Villagonzalo KA, 2010, EXPERT OPIN THER TAR, V14, P1301, DOI 10.1517/14728222.2010.528394
   Walters J, 2000, LAB HEMATOL, V6, P83
   Weintraub K, 2011, NATURE, V479, P22, DOI 10.1038/479022a
NR 50
TC 0
Z9 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
AR 432616
DI 10.1155/2013/432616
PG 11
WC Cell Biology; Immunology
SC Cell Biology; Immunology
GA 279TX
UT WOS:000328983400001
ER

PT J
AU Jahja, R
   Huijbregts, SCJ
   de Sonneville, LMJ
   van der Meere, JJ
   Bosch, AM
   Hollak, CEM
   Rubio-Gozalbo, ME
   Brouwers, MCGJ
   Hofstede, FC
   de Vries, MC
   Janssen, MCH
   van der Ploeg, AT
   Langendonk, JG
   van Spronsen, FJ
AF Jahja, Rianne
   Huijbregts, Stephan C. J.
   de Sonneville, Leo M. J.
   van der Meere, Jaap J.
   Bosch, Annet M.
   Hollak, Carla E. M.
   Rubio-Gozalbo, M. Estela
   Brouwers, Martijn C. G. J.
   Hofstede, Floris C.
   de Vries, Maaike C.
   Janssen, Mirian C. H.
   van der Ploeg, Ans T.
   Langendonk, Janneke G.
   van Spronsen, Francjan J.
TI Mental health and social functioning in early treated Phenylketonuria:
   The PKU-COBESO study
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Article
DE PKU-COBESO; Phenylketonuria; Childhood phenylalanine; Mental health;
   Social functioning
ID ASPERGER-SYNDROME; EXECUTIVE FUNCTION; CHILDREN; AUTISM; ADULTS;
   ADOLESCENTS; PUNISHMENT; PROFILE; MEMORY; REWARD
AB This article presents a new Dutch multicenter study ("PKU-COBESO") into cognitive and behavioral sequelae of early and continuously treated Phenylketonuria (PKU) patients. Part of the study sample will consist of young adult PKU patients who have participated in a large neuropsychological study approximately 10 years ago, when they were 7-to-15-year-olds (Huijbregts et al., 2002 [1]). Their neurocognitive development will be mapped in association with their earlier and continued metabolic history, taking into account possible changes in, for instance, medication.
   A second part of the sample will consist of PKU patients between the ages of 7 and approximately 40 years (i.e., born in or after 1974, when neonatal screening was introduced in The Netherlands), who have not participated in the earlier neuropsychological study. Again, their cognitive functioning will be related to their metabolic history. With respect to aspects of cognition, there will be an emphasis on executive functioning. The concept of executive functioning will however be extended with further emphasis on the impact of cognitive deficits on the daily lives of PKU patients, aspects of social cognition, social functioning, and behavior/mental health (i.e., COgnition, BEhavior, SOcial functioning: COBESO).
   In addition to a description of the PKU-COBESO study, some preliminary results with respect to mental health and social functioning will be presented in this article. Thirty adult PKU patients (mean age 27.8, SD 6.4) and 23 PKU patients under the age of 18 years (mean age 11.0, SD 33) were compared to 14 (mean age 26.9 years, SD 5.9) and 7 matched controls (mean age 10.5, SD 2.6) respectively, with respect to their scores on the Adult Self-Report or Child Behavior Checklist (measuring mental health problems) and the Social Skills Checklist or Social Skills Rating System (measuring social skills).
   Whereas there were very few significant group differences (except for mental health problems in the internalizing spectrum for adult PKU patients), possibly due to the small control groups, several significant associations between mental health problems and Phe levels were observed for the PKU patients. Childhood Phe levels and internalizing problems for adult PKU patients were related; concurrent Phe was associated with both internalizing and externalizing behavioral problems for those under the age of 18. These preliminary results underline the importance of early dietary adherence. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Jahja, Rianne; van Spronsen, Francjan J.] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Groningen, Netherlands.
   [Huijbregts, Stephan C. J.; de Sonneville, Leo M. J.] Leiden Univ, Leiden Inst Brain & Cognit, Dept Clin Child & Adolescent Studies, Leiden, Netherlands.
   [van der Meere, Jaap J.] Univ Groningen, Dept Dev & Clin Neuropsychol, Groningen, Netherlands.
   [Bosch, Annet M.; Hollak, Carla E. M.] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands.
   [Rubio-Gozalbo, M. Estela; Brouwers, Martijn C. G. J.] Univ Limburg, Acad Hosp Maastricht, Maastricht, Netherlands.
   [Hofstede, Floris C.] Univ Med Ctr Utrech, Wilhelmina Childrens Hosp, Utrecht, Netherlands.
   [de Vries, Maaike C.; Janssen, Mirian C. H.] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands.
   [van der Ploeg, Ans T.; Langendonk, Janneke G.] Erasmus MC, Rotterdam, Netherlands.
RP Jahja, R (reprint author), Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Div Metab Dis CA33, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM jahjar@umcg.nl
RI rubio, estela/H-1833-2011
FU ZorgOnderzoek Nederland [28-2719]; Dutch PKU Research Foundation;
   NutsOhra Fund; University Medical Center Groningen, the Netherlands
FX ZorgOnderzoek Nederland (no. 28-2719), the Dutch PKU Research
   Foundation, NutsOhra Fund, and the University Medical Center Groningen,
   the Netherlands.
CR Achenbach TM, 2003, MANUAL ASEBA ADULT F
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Anjema K, 2011, MOL GENET METAB, V104, P231, DOI 10.1016/j.ymgme.2011.05.017
   Arnold GL, 1998, ACTA PAEDIATR, V87, P565, DOI 10.1080/08035259850158308
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Blau N, 2010, LANCET, V376, P1417, DOI 10.1016/S0140-6736(10)60961-0
   Cappelletti S., 2013, J DEV BEHAV PEDIATR, P1
   CARVER CS, 1994, J PERS SOC PSYCHOL, V67, P319, DOI 10.1037/0022-3514.67.2.319
   Catroppa C., 2008, EXECUTIVE FUNCTIONS, P439
   Channon S, 2005, NEUROPSYCHOLOGY, V19, P679, DOI 10.1037/0894-4105.19.5.679
   Christ SE, 2010, MOL GENET METAB, V99, pS22, DOI 10.1016/j.ymgme.2009.10.007
   de Sonneville LMJ, 2010, MOL GENET METAB, V99, pS10, DOI 10.1016/j.ymgme.2009.10.177
   DeRoche K, 2008, DEV NEUROPSYCHOL, V33, P474, DOI 10.1080/87565640802101482
   de Sonneville LMJ, 1999, COMP PSYCH, V6, P187
   Gioia GA, 2000, BEHAV RATING INVENTO
   Gresham F. M., 1990, SOCIAL SKILLS RATING
   Huijbregts SCJ, 2003, NEUROPSYCHOLOGY, V17, P369, DOI 10.1037/0894-4105.17.3.369
   Huijbregts SCJ, 2002, NEUROSCI BIOBEHAV R, V26, P697, DOI 10.1016/S0149-7634(02)00040-4
   Kolb B., 2003, FUNDAMENTALS HUMAN N
   Kort W., 2008, CELF 4 NL CLIN EV LA
   Luman M, 2012, J ABNORM CHILD PSYCH, V40, P145, DOI 10.1007/s10802-011-9547-x
   Novotni M., 2000, NOVOTNI SOCIAL SKILL
   Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x
   Peters B. D., 2013, BIOL PSYCHI IN PRESS
   Roth R, 2005, BRIEF A BEHAV RATING
   Smith I, 2000, EUR J PEDIATR, V159, pS89, DOI 10.1007/PL00014392
   ten Hoedt AE, 2011, J INHERIT METAB DIS, V34, P165, DOI 10.1007/s10545-010-9253-9
   Van Manen T. G., 2007, SOCIAAL COGNITIEVE V
   Verrips GHW, 2000, CHILD CARE HLTH DEV, V26, P457, DOI 10.1046/j.1365-2214.2000.00181.x
   Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   Weglage J, 2000, J INHERIT METAB DIS, V23, P487, DOI 10.1023/A:1005664231017
   White DA, 2001, NEUROPSYCHOLOGY, V15, P221, DOI 10.1037/0894-4105.15.2.221
   ZIMET GD, 1988, J PERS ASSESS, V52, P30, DOI 10.1207/s15327752jpa5201_2
NR 36
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
EI 1096-7206
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PY 2013
VL 110
SU S
BP S57
EP S61
DI 10.1016/j.ymgme.2013.10.011
PG 5
WC Biochemistry & Molecular Biology; Genetics & Heredity; Medicine,
   Research & Experimental
SC Biochemistry & Molecular Biology; Genetics & Heredity; Research &
   Experimental Medicine
GA 278GG
UT WOS:000328876600009
PM 24183792
ER

PT J
AU Gerhant, A
   Olajossy, M
   Olajossy-Hilkesberger, L
AF Gerhant, Aneta
   Olajossy, Marcin
   Olajossy-Hilkesberger, Luiza
TI Neuroanatomical, genetic and neurochemical aspects of infantile autism
SO PSYCHIATRIA POLSKA
LA Polish
DT Article
DE infantile autism; neuroanatomy; neurotramsmiters
ID SEROTONIN TRANSPORTER GENE; SPECTRUM DISORDERS; REPETITIVE BEHAVIORS;
   CHILDREN; BRAIN; METAANALYSIS; OXYTOCIN; LINKAGE; ABNORMALITIES;
   ADOLESCENTS
AB Infantile autism is a neurodevelopmental disorder characterized by impairments in communication, reciprocal social interaction and restricted repetitive behaviors or interests. Although the cause of these disorders is not yet known, studies strongly suggest a genetic basis with a complex mode of inheritance. The etiopathogenetic processes of autism are extremely complex, which is reflected in the varying course and its symptomatology. Trajectories of brain development and volumes of its structures are aberrant in autistic patients. It is suggested that disturbances in sertotoninergic, gabaergic, glutaminergic, cholinergic and dopaminergic neurotransmission can be responsible for symptoms of autism as well as can disturb the development of the young brain. The objective of this article is to present the results of reasearch on neuroanatomical, neurochemical and genetic aspects of autism.
C1 [Gerhant, Aneta] Wojewodzki Szpital Nerwowo & Psychicznie Chorych, PL-21305 Suchowola, Poland.
   [Olajossy, Marcin; Olajossy-Hilkesberger, Luiza] Katedra & Klin Psychiat UM, Lublin, Poland.
RP Gerhant, A (reprint author), Wojewodzki Szpital Nerwowo & Psychicznie Chorych, PL-21305 Suchowola, Poland.
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   [Anonymous], 1998, KLAS ZAB PSYCH ZAB Z
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Blatt GJ, 2001, J AUTISM DEV DISORD, V31, P537, DOI 10.1023/A:1013238809666
   Bradford Y, 2001, AM J MED GENET, V105, P539, DOI 10.1002/ajmg.1497
   Brune CW, 2006, AM J PSYCHIAT, V163, P2148, DOI 10.1176/appi.ajp.163.12.2148
   Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9
   Chung MK, 2004, NEUROIMAGE, V23, P242, DOI 10.1016/j.neuroimage.2004.04.037
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Deutsch SI, 2010, CLIN NEUROPHARMACOL, V33, P114, DOI 10.1097/WNF.0b013e3181d6f7ad
   Ernst M, 1997, LANCET, V350, P638, DOI 10.1016/S0140-6736(05)63326-0
   Farzin F, 2006, J DEV BEHAV PEDIATR, V27, pS137, DOI 10.1097/00004703-200604002-00012
   Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0
   Fombonne Eric, 2009, Mcgill J Med, V12, P73
   GILLBERG C, 1983, J AUTISM DEV DISORD, V13, P383, DOI 10.1007/BF01531587
   Green LA, 2001, BIOL PSYCHIAT, V50, P609, DOI 10.1016/S0006-3223(01)01139-8
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
   Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040
   Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
   Huang CH, 2008, AM J MED GENET B, V147B, P903, DOI 10.1002/ajmg.b.30720
   Hussman JP, 2001, J AUTISM DEV DISORD, V31, P247, DOI 10.1023/A:1010715619091
   KORNHUBER J, 1989, LIFE SCI, V45, P745, DOI 10.1016/0024-3205(89)90094-5
   Kumar RA, 2009, CURR NEUROL NEUROSCI, V9, P188, DOI 10.1007/s11910-009-0029-2
   LaSalle JM, 2009, EPIGENOMICS-UK, V1, P119, DOI [10.2217/epi.09.13, 10.2217/EPI.09.13]
   Lee M, 2002, BRAIN, V125, P1483, DOI 10.1093/brain/awf160
   Levisohn PM, 2007, EPILEPSIA, V48, P33, DOI 10.1111/j.1528-1167.2007.01399.x
   Losh M, 2008, J NEUROPATH EXP NEUR, V67, P829, DOI 10.1097/NEN.0b013e318184482d
   Losh M, 2008, AM J MED GENET B, V147B, P424, DOI 10.1002/ajmg.b.30612
   Makkonen I, 2008, DEV MED CHILD NEUROL, V50, P593, DOI 10.1111/j.1469-8749.2008.03027.x
   Martin-Ruiz CM, 2004, MOL BRAIN RES, V123, P81, DOI 10.1016/j.molbrainres.2004.01.003
   McBride P. Anne, 1998, Journal of the American Academy of Child and Adolescent Psychiatry, V37, P767, DOI 10.1097/00004583-199807000-00017
   Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3
   Molloy CA, 2005, MOL PSYCHIATR, V10, P741, DOI 10.1038/sj.mp.4001691
   Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
   Myers SM, 2007, EXPERT OPIN PHARMACO, V8, P1579, DOI 10.1517/14656566.811.1579
   NARAYAN M, 1993, BIOL PSYCHIAT, V33, P630, DOI 10.1016/0006-3223(93)90102-J
   Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
   Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
   Perkins T, 2010, J CLIN NEUROSCI, V17, P1239, DOI 10.1016/j.jocn.2010.01.026
   Perry EK, 2001, AM J PSYCHIAT, V158, P1058, DOI 10.1176/appi.ajp.158.7.1058
   Pisula E., 2005, MALE DZIECKO AUTYZME
   Robinson PD, 2001, AM J MED GENET, V100, P30, DOI 10.1002/ajmg.1187
   RUTTER M, 1994, J CHILD PSYCHOL PSYC, V35, P311, DOI 10.1111/j.1469-7610.1994.tb01164.x
   Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004
   Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007
   Shinohe A, 2006, PROG NEURO-PSYCHOPH, V30, P1472, DOI 10.1016/j.pnpbp.2006.06.013
   Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Szatmari P, 1998, J AUTISM DEV DISORD, V28, P351, DOI 10.1023/A:1026096203946
   Tordjman S, 2001, MOL PSYCHIATR, V6, P434, DOI 10.1038/sj.mp.4000873
   Trikalinos TA, 2006, MOL PSYCHIATR, V11, P29, DOI 10.1038/sj.mp.4001750
   Wciorka J., 2008, KRYTERIA DIAGNOSTYCZ
   Webb SJ, 2009, PSYCHIAT RES-NEUROIM, V172, P61, DOI 10.1016/j.pscychresns.2008.06.001
   Whitaker-Azmitia PM, 2001, BRAIN RES BULL, V56, P479, DOI 10.1016/S0361-9230(01)00615-3
   Wills S, 2011, MOL AUTISM, V26, P2
NR 55
TC 1
Z9 1
PU WYDAWNICZY POLSKIEGO TOWARZYSTWA
PI CRACOW
PA LENARTOWICZA 14 STRREET,, CRACOW, 31-138, POLAND
SN 0033-2674
J9 PSYCHIATR POL
JI Psychiatr. Pol.
PY 2013
VL 47
IS 6
BP 1101
EP 1111
PG 11
WC Psychiatry
SC Psychiatry
GA 278QM
UT WOS:000328904800012
PM 25007541
ER

PT J
AU Fu, XY
   Mei, Z
   Sun, LX
AF Fu, Xiaoyan
   Mei, Zhu
   Sun, Lixin
TI Association between the g.296596G > A genetic variant of RELN gene and
   susceptibility to autism in a Chinese Han population
SO GENETICS AND MOLECULAR BIOLOGY
LA English
DT Article
DE autism; susceptibility; association analysis; RELN gene; genetic
   variants
ID REELIN GENE; SPECTRUM DISORDER; SEROTONIN TRANSPORTER; COMMERCIAL
   CATTLE; CANDIDATE GENE; POLYMORPHISMS; ALLELES; LINKAGE; OXTR; REPEAT
AB Autism is a childhood neuro-developmental disorder, and Reelin (RELN) is an important candidate gene for influencing autism. This study aimed at investigating the influence of genetic variants of the RELN gene on autism susceptibility. In this study, 205 autism patients and 210 healthy controls were recruited and the genetic variants of the RELN gene were genotyped by the created restriction site-polymerase chain reaction (CRS-PCR) method. The influence of genetic variants on autism susceptibility was analyzed by association analysis, and the g.296596G > A genetic variant in exon10 of the RELN gene was detected. The frequencies of allele/genotype in autistic patients were significantly different from those in healthy controls, and a statistically significant association was detected between this genetic variant and autism susceptibility. Our data lead to the inference that the g.296596G > A genetic variant in the RELN gene has a potential influence on autism susceptibility in the Chinese Han population.
C1 [Fu, Xiaoyan; Mei, Zhu; Sun, Lixin] Tongji Univ, Tongji Hosp, Dept Pediat, Shanghai 200065, Peoples R China.
RP Fu, XY (reprint author), Tongji Univ, Tongji Hosp, Dept Pediat, 389 Xincun Rd, Shanghai 200065, Peoples R China.
EM xiaoyanfu_12@sina.com
CR Ashley-Koch AE, 2007, PSYCHIAT GENET, V17, P221, DOI 10.1097/YPG.0b013e32809c2f75
   Bartlett CW, 2005, INT J DEV NEUROSCI, V23, P221, DOI 10.1016/j.ijdevneu.2004.10.004
   Bonora E, 2003, MOL PSYCHIATR, V8, P885, DOI 10.1038/sj.mp.4001310
   Cook EH, 1997, MOL PSYCHIATR, V2, P247
   Devlin B, 2004, AM J MED GENET B, V126B, P46, DOI 10.1002/ajmg.b.20125
   Dutta S, 2008, NEUROSCI LETT, V441, P56, DOI 10.1016/j.neulet.2008.06.022
   Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
   Gharani N, 2004, MOL PSYCHIATR, V9, P474, DOI 10.1038/sj.mp.4001498
   HALIASSOS A, 1989, NUCLEIC ACIDS RES, V17, P3606, DOI 10.1093/nar/17.9.3606
   He YQ, 2011, PSYCHIAT RES, V187, P462, DOI 10.1016/j.psychres.2010.04.051
   Holt R, 2010, EUR J HUM GENET, V18, P1013, DOI 10.1038/ejhg.2010.69
   Palferman S, 2001, AM J HUM GENET, V69, P570
   Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
   Krebs MO, 2002, MOL PSYCHIATR, V7, P801, DOI 10.1038/sj.mp.4001071
   Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087
   Li H, 2008, AM J MED GENET B, V147B, P194, DOI 10.1002/ajmg.b.30584
   Li J, 2004, AM J MED GENET B, V126B, P51, DOI 10.1002/ajmg.b.20122
   Monaco AP, 2001, LANCET, pS3
   Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850
   PETIT E, 1995, J MED GENET, V32, P269, DOI 10.1136/jmg.32.4.269
   Serajee FJ, 2006, GENOMICS, V87, P75, DOI 10.1016/j.ygeno.2005.09.008
   Skaar DA, 2005, MOL PSYCHIATR, V10, P563, DOI 10.1038/sj.mp.4001614
   Tian P, 2012, NEUROL INDIA, V60, P581, DOI 10.4103/0028-3886.105190
   Turner M, 2000, MOL MED TODAY, V6, P238, DOI 10.1016/S1357-4310(00)01712-3
   Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
   Yirmiya N, 2001, AM J MED GENET, V105, P381, DOI 10.1002/ajmg.1365
   Yuan ZR, 2012, GENE, V505, P190, DOI 10.1016/j.gene.2012.05.010
   Yuan ZR, 2013, MOL BIOL REP, V40, P1947, DOI 10.1007/s11033-012-2251-2
   Yuan ZR, 2013, MOL BIOL REP, V40, P7, DOI 10.1007/s11033-012-1934-z
   Zhang H, 2002, MOL PSYCHIATR, V7, P1012, DOI 10.1038/sj.mp.4001124
   Zhao Chun-Jiang, 2003, Yichuan, V25, P327
   Zhong H, 2003, J Med Genet, V40, pe4, DOI 10.1136/jmg.40.1.e4
NR 32
TC 0
Z9 0
PU SOC BRASIL GENETICA
PI RIBEIRAO PRET
PA RUA CAP ADELMIO NORBET DA SILVA, 736, ALTO DA BOA VISTA, 14025-670
   RIBEIRAO PRET, BRAZIL
SN 1415-4757
EI 1678-4685
J9 GENET MOL BIOL
JI Genet. Mol. Biol.
PY 2013
VL 36
IS 4
BP 486
EP 489
PG 4
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 275UI
UT WOS:000328702800003
PM 24385848
ER

PT J
AU Mbati, L
AF Mbati, Lydia
TI Online Social Media Applications for Constructivism and Observational
   Learning
SO INTERNATIONAL REVIEW OF RESEARCH IN OPEN AND DISTANCE LEARNING
LA English
DT Article
DE Learning management systems; online social media; constructivism;
   observational learning
ID VIDEO; CHILDREN; AUTISM; MODEL; TEACHERS; SELF
AB Web 2.0 technologies have a range of possibilities for fostering constructivist learning and observational learning. This is due to the available applications which allow for synchronous and asynchronous interaction and the sharing of knowledge between users. Web 2.0 tools include online social media applications which have potential pedagogical benefits. Despite these potential benefits, there is inadequate utilization of online social media applications in learning management systems for pedagogical purposes. Reasons cited for the limited uptake of online social media applications in learning management systems include the lack of consideration regarding the pedagogical benefits of these applications (Christie & Garrote-Jurado, 2009, pp. 273-279). There is limited information regarding experiences of the use of online social media that foster constructivist and observational learning. Using a qualitative meta-ethnographic approach, this article explores the experiences of students and instructors regarding online social media applications for constructivism and observational learning. Constructivist criteria (Baviskar, Hartle, & Whitney, 2009, pp. 543-544) and observational learning, based on Bandura's (2001, pp. 265-299) social cognitive theory, formed the theoretical grounding for this research. The findings suggest that discussion forums are ideal for the stimulation of constructivism and observational learning in online learning programmes.
C1 Univ S Africa, ZA-0001 Pretoria, South Africa.
RP Mbati, L (reprint author), Univ S Africa, ZA-0001 Pretoria, South Africa.
CR Al-Fadhli S, 2009, ASSESS EVAL HIGH EDU, V34, P529, DOI 10.1080/02602930802117032
   Bandura A, 2001, MEDIA PSYCHOL, V3, P265, DOI 10.1207/S1532785XMEP0303_03
   Bandura A., 1986, SOCIAL FDN THOUGHT A
   Black Elizabeth L., 2010, J LIB ADM, V50, P458
   Boster M., 2009, THESIS WALDEN U MINN
   Charlop M. H., 2010, ED TREATMENT CHILDRE, V33, P371, DOI DOI 10.1353/ETC.0.0104
   Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
   Chen CH, 2011, BRIT J EDUC TECHNOL, V42, pE5, DOI 10.1111/j.1467-8535.2010.01143.x
   Clark R., 2008, E LEARNING SCI INSTR, V2nd
   Coates H., 2005, TERTIARY ED MANAGEME, V11, P19, DOI DOI 10.1007/511233-004-3567-9
   Craig SD, 2009, J EDUC PSYCHOL, V101, P779, DOI 10.1037/a0016601
   Dalsgaard C., 2006, SOCIAL SOFTWARE E LE
   DeArment C., 2002, THESIS U PITTSBURGH
   Geiger KB, 2010, J APPL BEHAV ANAL, V43, P279, DOI 10.1901/jaba.2010.43-279
   Hare R. D., 1988, QUALITATIVE RES METH, VII
   Hershey M., 2010, SOCIAL MEDIA REVOLUT
   Christie M, 2009, European Journal of Engineering Education, V34, DOI 10.1080/03043790903038841
   Juwah C., 2010, I OPEN DISTANCE LEAR
   Keen D, 2007, J DEV PHYS DISABIL, V19, P291, DOI 10.1007/s10882-007-9044-x
   LeBlanc L. A., 2010, ED TREATMENT CHILDRE, V33, P333
   Liang JC, 2008, EDUC TECHNOL SOC, V11, P226
   Loyens SMM, 2007, STUD HIGH EDUC, V32, P581, DOI 10.1080/03075070701573765
   Menard L. B., 2010, THESIS U S FLORIDA T
   Ndon U. T., 2006, THESIS U WISCONSIN M
   Ng'ambi D, 2012, EDUC TECHNOL SOC, V15, P181
   Nikopoulos CK, 2003, BEHAV INTERVENT, V18, P87, DOI 10.1002/bin.129
   Pritchard A., 2005, WAYS LEARNING LEARNI
   Sherer M, 2001, BEHAV MODIF, V25, P140, DOI 10.1177/0145445501251008
   Siemens G., 2009, HDB EMERGING TECHNOL
   Stefanone MA, 2010, J BROADCAST ELECTRON, V54, P508, DOI 10.1080/08838151.2010.498851
   Sultan WH, 2011, EDUC TECHNOL SOC, V14, P149
   Whitney T., 2009, INT J SCI ED, V31, P542
   Yang YF, 2010, BRIT J EDUC TECHNOL, V41, P287, DOI 10.1111/j.1467-8535.2009.00934.x
   Yi MY, 2003, INFORM SYST RES, V14, P146, DOI 10.1287/isre.14.2.146.16016
NR 34
TC 0
Z9 0
PU ATHABASCA UNIV PRESS
PI ATHABASCA
PA 1 UNIVERSITY DR, ATHABASCA, AB T9S 3A3, CANADA
SN 1492-3831
J9 INT REV RES OPEN DIS
JI Int. Rev. Res. Open Distance Learn.
PY 2013
VL 14
IS 5
BP 166
EP 184
PG 19
WC Education & Educational Research
SC Education & Educational Research
GA 273MO
UT WOS:000328539200010
ER

PT J
AU Vorsanova, SG
   Iourov, IY
   Voinova, VY
   Kurinnaya, OS
   Zelenova, MA
   Demidova, IA
   Ulas, EV
   Yurov, YB
AF Vorsanova, S. G.
   Iourov, I. Y.
   Voinova, V. Y.
   Kurinnaya, O. S.
   Zelenova, M. A.
   Demidova, I. A.
   Ulas, E. V.
   Yurov, Y. B.
TI Subchromosomal microdeletion identified by molecular karyotyping using
   DNA microarrays (array CGH) in Rett syndrome girls negative for MECP2
   gene mutations
SO ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA
LA Russian
DT Article
DE Rett syndrome; autism; mental retardation; genome; DNA microarrays;
   molecular karyotyping; genomic and chromosomal abnormalities
ID RUSSIAN COHORT; DELETIONS; DIAGNOSIS; DISEASES; CHILDREN
AB Molecular karyotyping using DNA microarrays (array CGH) was applied for identification of subchromosomal microdeletions in a cohort of 12 girls with clinical features of RETT syndrome, but negative for MECP2 gene mutations. Recurrent microdeletions of MECP2 gene in chromosome X (locus Xq28) were identified in 5 girls of 12 studied. Probably RTT girls with subchromosomic microdeletions in Xq28 could represent a special subtype of the disease, which appears as clinically milder than the classic form of disease. In one case, an atypical form of RTT was associated with genomic abnormalities affecting CDKL5 gene and region critical for microdeletion Prader-Willi and Angelman syndromes (15q11.2). In addition, data are presented for the first time that genetic variation in regions 3p13, 3q27.1, and 1q21.1-1q21.2 could associate with RTT-like clinical manifestations. Without application of molecular karyotyping technology and bioinformatic method of assessing the pathogenic significance of genomic rearrangements these RU-like girls negative for MECP2 gene mutations were considered as cases of idiopathic mental retardation associated with autism. It should be noted that absence of intragenic mutations in MECP2 gene is not sufficient criteria to reject the clinical diagnosis of RTT. To avoid errors in the genetic diagnosis of this genetically heterogeneous brain disease molecular cytogenetic studies using high resolution oligonucleotide array CGH (molecular karyotyping) are needed.
C1 [Vorsanova, S. G.] Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia.
   Minist Hlth, Inst Paediat & Paediat Surg, Moscow, Russia.
   Moscow City Univ Psychol & Educ, Moscow, Russia.
RP Vorsanova, SG (reprint author), Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia.
EM svorsanova@mail.ru
RI Iourov, Ivan/O-7684-2014
OI Iourov, Ivan/0000-0002-4134-8367
CR [Anonymous], 2001, BRAIN DEV, V23, P196
   Dastidar SG, 2012, J NEUROSCI, V32, P2846, DOI 10.1523/JNEUROSCI.5841-11.2012
   Florian C., 2012, MOL SYNDROMOL, V2, p[3, 153]
   Hardwick SA, 2007, EUR J HUM GENET, V15, P1218, DOI 10.1038/sj.ejhg.5201911
   Horn D, 2012, MOL SYNDROMOL, V2, P213, DOI 10.1159/000330916.
   Iourov IY, 2012, MOL CYTOGENET, V5, DOI 10.1186/1755-8166-5-46
   Iourov IY, 2008, CURR GENOMICS, V9, P452, DOI 10.2174/138920208786241216
   Mefford HC, 2008, NEW ENGL J MED, V359, P1685, DOI 10.1056/NEJMoa0805384
   Ravn Kirstine, 2005, Hum Mutat, V25, P324, DOI 10.1002/humu.9320
   Scala E, 2007, AM J MED GENET A, V143A, P2775, DOI 10.1002/ajmg.a.32002
   Smeets EE, 2012, MOL SYNDROMOL, V2, P113
   Tiganov AS, 2012, VESTNIK RAMN, V9, P45
   VARSANOVA SG, 2008, GETEROKHROMATINOVYE, P300
   VARSANOVA SG, 2006, MEDITSINSKAYA TSITOG, P300
   VOINOVA VY, 2009, MED GENET, V8, P9
   Vorsanova S. G., 2001, BRAIN DEV, V23, P191
   Vorsanova SG, 2010, CURR GENOMICS, V11, P440, DOI 10.2174/138920210793176010
   Vorsanova SG, 2004, J PEDIAT NEUROL, V2, P179
   Vorsanova SG, 1996, NEUROREPORT, V8, P187, DOI 10.1097/00001756-199612200-00038
   VORSANOVA SG, 2013, FUNDAENTAL RES, V4, P356
   Vorsanova S. G., 2006, Rossiiskii Vestnik Perinatologii i Pediatrii, V51, P23
   Vorsanova SG, 2002, ZH NEVROPATOL PSIKH, V102, P23
   Weng SM, 2011, PEDIATR NEONATOL, V52, P309, DOI 10.1016/j.pedneo.2011.08.002
   Yurov IY, 2005, Z NEVROL PSIKHIATRII, V105, P4
   YUROV IY, 2012, KLIN GENETIKA PERINA, V1, P50
   YUROV IY, 2012, SOVR PROBLEMY NAUKI, V3, P5
   YUROV IY, 2007, VOPROSY SOVREMENNOY, V6, P38
NR 27
TC 0
Z9 0
PU IZDATELSTVO MEDITSINA
PI MOSCOW
PA PETROVERIGSKII PER 6-8, K-142 MOSCOW, RUSSIA
SN 1997-7298
J9 ZH NEVROL PSIKHIATR
JI Z. Nevrol. Psikhiatrii Im S S Korsakova
PY 2013
VL 113
IS 10
BP 63
EP 68
PG 6
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 268QJ
UT WOS:000328185300012
PM 24300809
ER

PT J
AU Popa-Wagner, A
   Mitran, S
   Sivanesan, S
   Chang, E
   Buga, AM
AF Popa-Wagner, Aurel
   Mitran, Smaranda
   Sivanesan, Senthilkumar
   Chang, Edwin
   Buga, Ana-Maria
TI ROS and Brain Diseases: The Good, the Bad, and the Ugly
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID DEFICIT HYPERACTIVITY DISORDER; RECEPTOR-GAMMA AGONISTS; FOCAL
   CEREBRAL-ISCHEMIA; CYTOCHROME-C-OXIDASE; OXIDATIVE STRESS PARAMETERS;
   AUTISM SPECTRUM DISORDERS; HYPERBARIC-OXYGEN THERAPY; AMYLOID
   BETA-PEPTIDE; TOLL-LIKE RECEPTOR-4; NF-KAPPA-B
AB The brain is a major metabolizer of oxygen and yet has relatively feeble protective antioxidant mechanisms. This paper reviews the Janus-faced properties of reactive oxygen species. It will describe the positive aspects of moderately induced ROS but it will also outline recent research findings concerning the impact of oxidative and nitrooxidative stress on neuronal structure and function in neuropsychiatric diseases, including major depression. A common denominator of all neuropsychiatric diseases including schizophrenia and ADHD is an increased inflammatory response of the brain caused either by an exposure to proinflammatory agents during development or an accumulation of degenerated neurons, oxidized proteins, glycated products, or lipid peroxidation in the adult brain. Therefore, modulation of the prooxidant-antioxidant balance provides a therapeutic option which can be used to improve neuroprotection in response to oxidative stress. We also discuss the neuroprotective role of the nuclear factor erythroid 2-related factor (Nrf2) in the aged brain in response to oxidative stressors and nanoparticle-mediated delivery of ROS-scavenging drugs. The antioxidant therapy is a novel therapeutic strategy. However, the available drugs have pleiotropic actions and are not fully characterized in the clinic. Additional clinical trials are needed to assess the risks and benefits of antioxidant therapies for neuropsychiatric disorders.
C1 [Popa-Wagner, Aurel; Buga, Ana-Maria] Univ Rostock, Sch Med, Dept Psychiat, D-18147 Rostock, Germany.
   [Mitran, Smaranda; Buga, Ana-Maria] Univ Med & Pharm, Ctr Clin & Expt Med, Craiova 200349, Romania.
   [Sivanesan, Senthilkumar] Iowa State Univ Sci & Technol, Coll Vet Med, Dept Biomed Sci, Ames, IA 50011 USA.
   [Chang, Edwin] Stanford Univ, Sch Med, MIPS, Canary Ctr Stanford Canc Early Detect, Palo Alto, CA 94304 USA.
RP Popa-Wagner, A (reprint author), Univ Rostock, Sch Med, Dept Psychiat, Gehlsheimer Str 20, D-18147 Rostock, Germany.
EM aurel.popa-wagner@med.uni-rostock.de
RI Popa-Wagner, Aurel/E-2541-2013
FU UEFISCDI; PN-II-PCCA [80]; UEFISCDI FLARE2
FX This study was supported by UEFISCDI, PN-II-PCCA-2011 Grant no. 80, to
   Aurel Popa-Wagner and UEFISCDI FLARE2 to Ana-Maria Buga.
CR Akyol O, 2002, PROG NEURO-PSYCHOPH, V26, P995, DOI 10.1016/S0278-5846(02)00220-8
   Arranz MJ, 2007, MOL PSYCHIATR, V12, P707, DOI 10.1038/sj.mp.4002009
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Atkins CM, 1999, J NEUROSCI, V19, P7241
   Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   Badjatia N, 2012, STROKE, V43, P691, DOI 10.1161/STROKEAHA.111.636035
   Balistreri CR, 2009, J CLIN IMMUNOL, V29, P406, DOI 10.1007/s10875-009-9297-5
   Ben- David E, 2012, PLOS GENETICS, V8
   Bennet L, 2006, ADV EXP MED BIOL, V573, P204
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Bilbo SD, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.014.2009
   Bjelakovic G, 2007, JAMA-J AM MED ASSOC, V297, P842, DOI 10.1001/jama.297.8.842
   BlumDegen D, 1995, NEUROSCI LETT, V202, P17, DOI 10.1016/0304-3940(95)12192-7
   Boess FG, 2004, NEUROPHARMACOLOGY, V47, P1081, DOI 10.1016/j.neuropharm.2004.07.040
   Bornemann KD, 2001, AM J PATHOL, V158, P63, DOI 10.1016/S0002-9440(10)63945-4
   Bosetti F, 2002, NEUROBIOL AGING, V23, P371, DOI 10.1016/S0197-4580(01)00314-1
   Bouayed J, 2007, EUR J PHARMACOL, V564, P146, DOI 10.1016/j.ejphar.2007.02.055
   Bouayed J, 2009, OXID MED CELL LONGEV, V2, P63
   Bousquet M, 2011, AGEING RES REV, V10, P453, DOI 10.1016/j.arr.2011.03.001
   Buga AM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050985
   Bulut M, 2007, J PSYCHIATR NEUROSCI, V32, P435
   Bulut M, 2013, PSYCHIAT RES, V209, P638, DOI 10.1016/j.psychres.2013.02.025
   Campbell N. A., 2005, BIOLOGY
   Cardoso SM, 2004, NEUROBIOL AGING, V25, P105, DOI 10.1016/S0197-4580(03)00033-2
   Caso JR, 2007, CIRCULATION, V115, P1599, DOI 10.1161/CIRCULATIONAHA.106.603431
   Caso JR, 2008, STROKE, V39, P1314, DOI 10.1161/STROKEAHA.107.498212
   Ceylan M, 2010, PROG NEURO-PSYCHOPH, V34, P1491, DOI 10.1016/j.pnpbp.2010.08.010
   Chen G, 2013, AM J MED SCI, V345, P369, DOI 10.1097/MAJ.0b013e318271c031
   Chen SD, 2011, INT J MOL SCI, V12, P7199, DOI 10.3390/ijms12107199
   Chen ZY, 2006, SCIENCE, V314, P140, DOI 10.1126/science.1129663
   Cheng MY, 2011, TRANSL STROKE RES, V2, P92, DOI 10.1007/s12975-010-0060-2
   Chez MG, 2007, PEDIATR NEUROL, V36, P361, DOI 10.1016/j.pediatrneurol.2007.01.012
   Chuang DM, 2011, FRONT MOL NEUROSCI, V4, DOI 10.3389/fnmol.2011.00015
   Chungpaibulpatana Jessada, 2008, Journal of the Medical Association of Thailand, V91, P1232
   Cribbs DH, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-179
   Cristalli DO, 2012, J NEUROL SCI, V314, P48, DOI 10.1016/j.jns.2011.11.001
   Cui JK, 2000, FASEB J, V14, P955
   Dagda RK, 2009, J BIOL CHEM, V284, P13843, DOI 10.1074/jbc.M808515200
   del Zoppo GJ, 2000, THROMB RES, V98, pV73
   Dinkova-Kostova AT, 2002, P NATL ACAD SCI USA, V99, P11908, DOI 10.1073/pnas.172398899
   Dodd S, 2013, PROG NEURO-PSYCHOPH, V42, P135, DOI 10.1016/j.pnpbp.2012.11.007
   DOLE M, 1965, J GEN PHYSIOL, V49, P5, DOI 10.1085/jgp.49.1.5
   Drechsel DA, 2012, NEUROTOX RES, V22, P251, DOI 10.1007/s12640-012-9322-y
   Droge W, 2002, PHYSIOL REV, V82, P47
   Durand T, 2013, BIOCHIMIE, V95, P86, DOI 10.1016/j.biochi.2012.09.017
   Dwivedi Y, 2003, ARCH GEN PSYCHIAT, V60, P804, DOI 10.1001/archpsyc.60.8.804
   Fischer MT, 2012, BRAIN, V135, P886, DOI 10.1093/brain/aws012
   Flatow J, 2013, BIOL PSYCHIAT, V74, P400, DOI 10.1016/j.biopsych.2013.03.018
   Fredericks CA, 2010, BRAIN BEHAV IMMUN, V24, P350, DOI 10.1016/j.bbi.2009.10.014
   Frye R. E., 2013, TRANSLATIONAL PSYCHI, V3
   Gallagher DA, 2009, CURR TOP MED CHEM, V9, P860
   Gan L, 2012, J NEUROSCI, V32, P17775, DOI 10.1523/JNEUROSCI.3049-12.2012
   Gill R, 2010, FREE RADICAL BIO MED, V48, P1121, DOI 10.1016/j.freeradbiomed.2010.01.006
   Gilmore JH, 2004, NEUROPSYCHOPHARMACOL, V29, P1221, DOI 10.1038/sj.npp.1300446
   Godinez-Rubi M, 2013, OXID MED CELL LONGEV, DOI 10.1155/2013/297357
   Gonsette RE, 2008, J NEUROL SCI, V274, P48, DOI 10.1016/j.jns.2008.06.029
   Gonzalez-Scarano F, 1999, ANNU REV NEUROSCI, V22, P219, DOI 10.1146/annurev.neuro.22.1.219
   Grillo RW, 2007, J PSYCHIAT RES, V41, P31, DOI 10.1016/j.jpsychires.2006.01.005
   Gu F., 2013, TRANSLATIONAL PSYCHI, V3
   Guglielmotto M, 2009, THESCIENTIFICWORLDJO, V9, P781, DOI 10.1100/tsw.2009.93
   Gulec M, 2012, PROG NEURO-PSYCHOPH, V37, P247, DOI 10.1016/j.pnpbp.2012.02.011
   Halliwell B, 2006, J NEUROCHEM, V97, P1634, DOI 10.1111/j.1471-4159.2006.03907.x
   Hansson MJ, 2008, FREE RADICAL BIO MED, V45, P284, DOI 10.1016/j.freeradbiomed.2008.04.021
   Haraguchi T, 2010, BRAIN RES, V1353, P125, DOI 10.1016/j.brainres.2010.07.017
   Harari OA, 2010, ANN NY ACAD SCI, V1207, P32, DOI 10.1111/j.1749-6632.2010.05735.x
   Harris J, 2012, TEACHING SUBJECT: COMPOSITION SINCE 1966, P32
   Haxaire C, 2012, AGING CELL, V11, P336, DOI 10.1111/j.1474-9726.2012.00792.x
   Hirsch EC, 2009, LANCET NEUROL, V8, P382, DOI 10.1016/S1474-4422(09)70062-6
   Hong F, 2005, CHEM RES TOXICOL, V18, P1917, DOI 10.1021/tx0502138
   Hovatta I, 2010, NEUROSCI RES, V68, P261, DOI 10.1016/j.neures.2010.08.007
   Hoyer-Hansen M, 2010, TRENDS MOL MED, V16, P295, DOI 10.1016/j.molmed.2010.04.005
   Hu DY, 2006, J NEUROSCI, V26, P3933, DOI 10.1523/JNEUROSCI.5566-05.2006
   Hu XM, 2012, J NEUROIMMUNE PHARM, V7, P187, DOI 10.1007/s11481-011-9309-0
   Ilic TV, 1999, FUNCT NEUROL, V14, P141
   Iyengar R. L., 2013, AM J MED, V126
   Jenner P, 2006, NEUROLOGY, V66, pS24
   Ji Q, 2011, J SURG RES, V168, pE95, DOI 10.1016/j.jss.2011.01.057
   Jiang H, 2011, BIOL PHARM BULL, V34, P1194, DOI 10.1248/bpb.34.1194
   Jin JJ, 2008, J NEUROINFLAMM, V5, DOI 10.1186/1742-2094-5-23
   Joglar B, 2009, J NEUROCHEM, V109, P656, DOI 10.1111/j.1471-4159.2009.05999.x
   Johnson AW, 2013, P NATL ACAD SCI USA, V110, P12462, DOI 10.1073/pnas.1307925110
   Jorgensen A, 2013, J AFFECT DISORDERS, V149, P355, DOI 10.1016/j.jad.2013.02.011
   Joseph C, 2012, J CEREBR BLOOD F MET, V32, P1632, DOI 10.1038/jcbfm.2012.65
   Joshi K, 2006, PROSTAG LEUKOTR ESS, V74, P17, DOI 10.1016/j.plefa.2005.10.001
   Kaidery NA, 2013, ANTIOXID REDOX SIGN, V18, P139, DOI 10.1089/ars.2011.4491
   Kalaria RN, 1996, NEUROBIOL AGING, V17, P687
   KALRA J, 1992, MOL CELL BIOCHEM, V112, P181
   Kamat CD, 2008, J ALZHEIMERS DIS, V15, P473
   Kano S., 2012, MOL PSYCHIATR, V18, P740
   Kaufman J, 2006, BIOL PSYCHIAT, V59, P673, DOI 10.1016/j.biopsych.2005.10.026
   Kaundal RK, 2010, DRUG NEWS PERSPECT, V23, P241, DOI 10.1358/dnp.2010.23.4.1437710
   Khairova R, 2012, MOL MED REP, V5, P680, DOI 10.3892/mmr.2011.732
   Kishi T, 2012, J CARDIOL, V60, P489, DOI 10.1016/j.jjcc.2012.08.004
   Kitazawa M, 2004, ANN NY ACAD SCI, V1035, P85, DOI 10.1196/annals.1332.006
   Kosenko EA, 2012, CNS NEUROL DISORD-DR, V11, P926
   Kouti L, 2013, EUR REV MED PHARMACO, V17, P964
   Kubera M, 2011, J NEUROIMMUNOL, V240, P34, DOI 10.1016/j.jneuroim.2011.09.006
   Kulak A, 2013, ANTIOXID REDOX SIGN, V18, P1428, DOI 10.1089/ars.2012.4858
   Lakhan SE, 2009, J TRANSL MED, V7, DOI 10.1186/1479-5876-7-97
   L'Episcopo F., 2013, J NEUROSCI, V33, P1462
   Lee WC, 2012, BIOCHEM BIOPH RES CO, V425, P842, DOI 10.1016/j.bbrc.2012.08.002
   Lemasters JJ, 2009, BBA-BIOENERGETICS, V1787, P1395, DOI 10.1016/j.bbabio.2009.06.009
   Leuner K, 2012, MOL NEUROBIOL, V46, P194, DOI 10.1007/s12035-012-8300-y
   Leuner K, 2012, MOL NEUROBIOL, V46, P186, DOI 10.1007/s12035-012-8307-4
   Li JJ, 2012, BRAIN RES, V1486, P103, DOI 10.1016/j.brainres.2012.09.031
   Li Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035122
   Liaury K., 2012, J NEUROINFLAMMATION, V9
   Lim CM, 2009, J NEUROSCI RES, V87, P1037, DOI 10.1002/jnr.21899
   Love S, 1999, BRAIN PATHOL, V9, P119
   Lu SP, 2007, FREE RADICAL BIO MED, V42, P936, DOI 10.1016/j.freeradbiomed.2006.11.027
   Macchi F., 2013, J NEUROINFLAMMATION, V10
   Maes Michael, 2012, Inflammopharmacology, V20, P127, DOI 10.1007/s10787-011-0111-7
   Mancuso M, 2003, EXP NEUROL, V182, P421, DOI 10.1016/S0014-4886(03)00092-X
   Marazziti D, 2012, EUR REV MED PHARMACO, V16, P270
   Markesbery WR, 1999, BRAIN PATHOL, V9, P133
   Masood A, 2008, J PHARMACOL EXP THER, V326, P369, DOI 10.1124/jpet.108.137208
   McCracken E, 2000, J CEREBR BLOOD F MET, V20, P1529
   Mehta SL, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-79
   Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
   Michel TM, 2012, CURR PHARM DESIGN, V18, P5890
   Michel TM, 2011, WORLD J BIOL PSYCHIA, V12, P588, DOI 10.3109/15622975.2010.526146
   Milani P, 2013, OXID MED CELL LONGEV, V2013
   Ming X, 2008, J CHILD NEUROL, V23, P6, DOI 10.1177/0883073807307102
   Monji A, 2013, PROG NEURO-PSYCHOPH, V42, P115, DOI 10.1016/j.pnpbp.2011.12.002
   Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
   Nagotani S, 2005, STROKE, V36, P670, DOI 10.1161/01.STR.0000155732.27333.3c
   Najjar S., 2013, BIOL PSYCHIAT
   Ng F, 2008, INT J NEUROPSYCHOPH, V11, P851, DOI 10.1017/S1461145707008401
   Nichols TC, 2004, DRUG NEWS PERSPECT, V17, P99, DOI 10.1358/dnp.2004.17.2.829042
   Okun E, 2007, J NEUROCHEM, V102, P1232, DOI 10.1111/j.1471-4159.2007.04615.x
   Opii WO, 2007, J NEUROTRAUM, V24, P772, DOI 10.1089/neu.2006.0229
   Pabon MM, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-9
   Pandya CD, 2013, PROG NEURO-PSYCHOPH, V46, P214, DOI 10.1016/j.pnpbp.2012.10.017
   Panov A, 2007, AM J PHYSIOL-CELL PH, V292, pC708, DOI 10.1152/ajpcell.00202.2006
   Park SW, 2007, J PHARMACOL EXP THER, V320, P1002, DOI 10.1124/jpet.106.113472
   Pedrini M, 2011, NEUROSCI LETT, V491, P207, DOI 10.1016/j.neulet.2011.01.039
   Pereira MP, 2005, J NEUROPATH EXP NEUR, V64, P797
   Perez-de-Puig I, 2013, NEUROSCIENCE, V243, P22, DOI 10.1016/j.neuroscience.2013.03.046
   Pignitter M, 2006, FREE RADICAL BIO MED, V41, P455, DOI 10.1016/j.freeradbiomed.2006.04.004
   POLVANI S, 2012, PPAR RES
   Post RM, 2007, NEUROSCI BIOBEHAV R, V31, P858, DOI 10.1016/j.neubiorev.2007.04.003
   Potvin S, 2008, BIOL PSYCHIAT, V63, P801, DOI 10.1016/j.[)iopsych.2007-09.024
   Pradillo JM, 2009, J NEUROCHEM, V109, P287, DOI 10.1111/j.1471-4159.2009.05972.x
   Puertas MC, 2012, EXP GERONTOL, V47, P625, DOI 10.1016/j.exger.2012.05.019
   Qin LY, 2013, GLIA, V61, P855, DOI 10.1002/glia.22479
   Rasola A, 2010, FEBS LETT, V584, P1989, DOI 10.1016/j.febslet.2010.02.022
   Ratanayake U., 2013, FRONTIERS NEUROSCIEN, V17
   Reynolds AD, 2009, J IMMUNOL, V182, P4137, DOI 10.4049/jimmunol.0803982
   Rich PR, 2003, BIOCHEM SOC T, V31, P1095
   Richardson AJ, 2005, PEDIATRICS, V115, P1360, DOI 10.1542/peds.2004-2164
   Rose S, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.61
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P389, DOI 10.1038/mp.2011.165
   Rossignol DA, 2006, MED HYPOTHESES, V67, P216, DOI 10.1016/j.mehy.2006.02.009
   Sanders LH, 2013, FREE RADICAL BIO MED, V62, P111, DOI 10.1016/j.freeradbiomed.2013.01.003
   Selley ML, 1998, FREE RADICAL BIO MED, V25, P169, DOI 10.1016/S0891-5849(98)00021-5
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Sen S, 2003, NEUROPSYCHOPHARMACOL, V28, P397, DOI 10.1038/sj.npp.1300053
   Sklar P, 2002, MOL PSYCHIATR, V7, P579, DOI 10.1038/sj.mp.4001058
   Son TG, 2013, BIOCHEM BIOPH RES CO, V433, P602, DOI 10.1016/j.bbrc.2013.03.041
   Suzuki Y, 2012, SCI REP-UK, V2, DOI 10.1038/srep00896
   Talarowska M, 2012, NEUROSCI LETT, V510, P127, DOI 10.1016/j.neulet.2012.01.018
   Tang SC, 2008, EXP NEUROL, V213, P114, DOI 10.1016/j.expneurol.2008.05.014
   Tobe EH, 2013, NEUROPSYCH DIS TREAT, V9, P567, DOI 10.2147/NDT.S44282
   Tsaluchidu S, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-S1-S5
   Tuohimaa P, 2009, Psychoneuroendocrinology, V34 Suppl 1, pS278, DOI 10.1016/j.psyneuen.2009.07.003
   Tureyen K, 2007, J NEUROCHEM, V101, P41, DOI 10.1111/j.1471-4159.2006.04376.x
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Verri M, 2012, INT J IMMUNOPATH PH, V25, P345
   VERSACE A, 2013, MOL PSYCHIAT
   Wang X, 2013, ANTIOXID REDOX SIGN, V18, P1444, DOI 10.1089/ars.2012.4907
   Wang XH, 2009, ANTIMICROB AGENTS CH, V53, P1395, DOI 10.1128/AAC.01087-08
   Wang XY, 2003, MOL NEUROBIOL, V28, P229, DOI 10.1385/MN:28:3:229
   Washida K, 2010, STROKE, V41, P1798, DOI 10.1161/STROKEAHA.110.583948
   Wehner NG, 2009, BIRTH DEFECTS RES B, V86, P108, DOI 10.1002/bdrb.20191
   Wei ZL, 2011, STROKE, V42, P2589, DOI 10.1161/STROKEAHA.111.614834
   Werner C, 2004, EUR J NEUROSCI, V20, P3498, DOI 10.1111/j.1460-9568.2004.03793.x
   Wu DC, 2003, P NATL ACAD SCI USA, V100, P6145, DOI 10.1073/pnas.0937239100
   Xu F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055080
   Yoshitomi T, 2011, BIOMATERIALS, V32, P8021, DOI 10.1016/j.biomaterials.2011.07.014
   Younessi Parisa, 2011, Iran J Med Sci, V36, P154
   Zeis T, 2009, BRAIN PATHOL, V19, P459, DOI 10.1111/j.1750-3639.2008.00231.x
   Zhang W, 2012, J NEUROL SCI, V315, P67, DOI 10.1016/j.jns.2011.11.032
NR 182
TC 0
Z9 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2013
DI 10.1155/2013/963520
PG 14
WC Cell Biology
SC Cell Biology
GA 271GC
UT WOS:000328378800001
ER

PT J
AU Bergeron, JDL
   Deslauriers, J
   Grignon, S
   Fortier, LC
   Lepage, M
   Sfroh, T
   Poyart, C
   Sebire, G
AF Bergeron, J. D. L.
   Deslauriers, J.
   Grignon, S.
   Fortier, L. C.
   Lepage, M.
   Sfroh, T.
   Poyart, C.
   Sebire, G.
TI White Matter Injury and Autistic-Like Behavior Predominantly Affecting
   Male Rat Offspring Exposed to Group B Streptococcal Maternal
   Inflammation
SO DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Autism; Group B streptococcus; Dysmyelination; Gestational inflammation
ID EXTREMELY PRETERM INFANTS; IMMUNE ACTIVATION; SPECTRUM DISORDERS;
   SCHIZOPHRENIA RESEARCH; PREPULSE INHIBITION; PRENATAL INFECTION;
   BRAIN-DEVELOPMENT; CEREBRAL-PALSY; MOTOR DEFICITS; ANIMAL-MODEL
AB The impact of the group B streptococcus (GBS)-induced maternal inflammation on offspring's brain has not yet been investigated despite GBS being one of the most frequent bacteria colonizing or infecting pregnant women. According to our hypothesis GBS-induced maternal immune activation plays a role in offspring perinatal brain damage and subsequent neurodisabilities such as autism. Using a new preclinical rat model of maternal inflammation triggered by inactivated GBS, we demonstrated placental, neuropathological and behavioral impacts on offspring. GBS-exposed placentas presented cystic lesions and polymorphonuclear infiltration located within the decidual/maternal side of the placenta, contrasting with macrophagic infiltration and necrotic areas located in the labyrinth/fetal compartment of the placenta after lipopolysaccharide-induced maternal inflammation. Brain damage featured lateral ventricles widening, predominately in the male, reduction of periventricular external capsules thickness, oligodendrocyte loss, and disorganization of frontoparietal subcortical tissue with no glial proliferation. Autistic hallmarks were found in offspring exposed to GBS, namely deficits in motor behavior, social and communicative impairments, i.e. profound defects in the integration and response to both acoustic and chemical signals that are predominant modes of communication in rats. Surprisingly, only male offspring were affected by these combined autistic-like traits. Our results show for the first time that materno-fetal inflammatory response to GBS plays a role in the induction of placental and cerebral insults, remarkably recapitulating cardinal features of human autism such as gender dichotomy and neurobehavioral traits. Unlike other models of prenatal inflammatory brain damage (induced by viral/toll-like receptor 3 (TLR3) or Gram-negative/TLR4), maternal inflammation resulting from GBS/TLR2 interactions induced a distinctive pattern of chorioamnionitis and cerebral injuries. These results also provide important evidence that beyond genetic influences, modifiable environmental factors play a role in both the occurrence of autism and its gender imbalance. (C) 2013 S. Karger AG, Basel
C1 [Bergeron, J. D. L.; Sebire, G.] Univ Sherbrooke, Dept Pediat, Sherbrooke, PQ J1K 2R1, Canada.
   [Deslauriers, J.; Grignon, S.] Univ Sherbrooke, Dept Physiol & Biophys, Sherbrooke, PQ J1K 2R1, Canada.
   [Grignon, S.] Univ Sherbrooke, Dept Psychiat, Sherbrooke, PQ J1K 2R1, Canada.
   [Fortier, L. C.] Univ Sherbrooke, Dept Microbiol, Sherbrooke, PQ J1K 2R1, Canada.
   [Lepage, M.] Univ Sherbrooke, Dept Med Nucl & Radiobiol, Sherbrooke, PQ J1K 2R1, Canada.
   [Sfroh, T.] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada.
   [Sfroh, T.] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ, Canada.
   McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada.
   [Poyart, C.] Univ Sorbonne Paris Descartes, Inst Cochin, Paris, France.
   [Poyart, C.] INSERM, U1016, Paris, France.
   [Poyart, C.] Hop Univ Paris Ctr Cochin Hotel Dieu Broca, AP HP, Serv Bacteriol, Ctr Natl Reference Streptocoques, Paris, France.
RP Sebire, G (reprint author), 3001 12eme Ave Nord, Sherbrooke, PQ J1H 5N4, Canada.
EM Guillaume.Sebire@USherbrooke.ca
RI Lepage, Martin/F-5743-2014
FU Fonds de la Recherche du Quebec-Sante (FRQ-S); Canadian Institutes of
   Health Research (CIHR); Foundation of Stars; Centre de Recherche
   Clinique Etienne Le Bel du CHUS
FX This work was supported by a scholarship from Fonds de la Recherche du
   Quebec-Sante (FRQ-S), a grant from the Canadian Institutes of Health
   Research (CIHR), and a grant from the Foundation of Stars to G.S. G.S.,
   M.L., L.C.F. and S.G. are members of the FRSQ-funded Centre de Recherche
   Clinique Etienne Le Bel du CHUS. G.S. and S.G. are members of the Centre
   de Neurosciences de l'Universite de Sherbrooke. G.S. is a member of the
   Centre de Recherche Mere & Enfant de l'Universite de Sherbrooke.
CR Abdallah MW, 2012, TURK PSIKIYATR DERG, V23, P229, DOI 10.5080/u6847
   Waldorf KMA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028972
   Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
   Atladottir HO, 2012, PEDIATRICS, V130, pE1447, DOI 10.1542/peds.2012-1107
   Baharnoori M, 2012, SCHIZOPHRENIA BULL, V38, P444, DOI 10.1093/schbul/sbq098
   Barnea-Goraly N, 2010, ARCH GEN PSYCHIAT, V67, P1052, DOI 10.1001/archgenpsychiatry.2010.123
   Bell MJ, 2002, J NEUROSCI RES, V70, P570, DOI 10.1002/jnr.10423
   Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
   Brochu ME, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-55
   Chabrier S, 2010, EUR J PAEDIATR NEURO, V14, P206, DOI 10.1016/j.ejpn.2009.05.004
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Du X, 2011, PLOS ONE, V6
   Fichorova RN, 2011, MBIO, V2, DOI 10.1128/mBio.00280-10
   Fortier ME, 2007, BEHAV BRAIN RES, V181, P270, DOI 10.1016/j.bbr.2007.04.016
   Girard S, 2012, BRAIN BEHAV IMMUN, V26, P1331, DOI 10.1016/j.bbi.2012.09.001
   Girard S, 2010, J IMMUNOL, V184, P3997, DOI 10.4049/jimmunol.0903349
   Girard S, 2009, NEUROSCIENCE, V158, P673, DOI 10.1016/j.neuroscience.2008.10.032
   Granholm AC, 2011, BRAIN PATHOL, V21, P330, DOI 10.1111/j.1750-3639.2010.00457.x
   GREGORY EH, 1971, PHYSIOL BEHAV, V6, P573, DOI 10.1016/0031-9384(71)90208-3
   Hagberg H, 2012, ANN NEUROL, V71, P444, DOI 10.1002/ana.22620
   Henneke P, 2008, J IMMUNOL, V180, P6149
   Kak V, 2012, MED CLIN N AM, V96, P455, DOI 10.1016/j.mcna.2012.04.002
   Kannan S, 2011, DEV NEUROSCI-BASEL, V33, P231, DOI 10.1159/000328125
   Kannan S, 2012, SCI TRANSL MED, V18, P130
   Kenyon S, 2008, LANCET, V372, P1319, DOI 10.1016/S0140-6736(08)61203-9
   Kim-Fine S, 2012, J MATERN-FETAL NEO M, V25, P2470, DOI 10.3109/14767058.2012.684165
   Kuban KCK, 2009, J PEDIATR-US, V154, P535, DOI 10.1016/j.jpeds.2008.10.011
   LANCEFIELD RC, 1975, J EXP MED, V142, P165, DOI 10.1084/jem.142.1.165
   Larroque B, 2008, LANCET, V371, P813, DOI 10.1016/S0140-6736(08)60380-3
   Larsen JW, 2008, AM J OBSTET GYNECOL, V198, P440, DOI 10.1016/j.ajog.2007.11.030
   Leviton A, 2010, PEDIATR RES, V67, P95, DOI 10.1203/PDR.0b013e3181bf5fab
   Limperopoulos C, 2008, PEDIATRICS, V121, P758, DOI 10.1542/peds.2007-2158
   Makinodan M, 2008, J NEUROSCI RES, V86, P2190, DOI 10.1002/jnr.21673
   Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011
   McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332
   Meyer U, 2012, NEUROPHARMACOLOGY, V62, P1308, DOI 10.1016/j.neuropharm.2011.01.009
   Nelson Karin B., 2000, Current Opinion in Neurology, V13, P133, DOI 10.1097/00019052-200004000-00004
   Pang Y, 2000, J NEUROSCI RES, V62, P510, DOI 10.1002/1097-4547(20001115)62:4<510::AID-JNR5>3.0.CO;2-F
   Parent AJ, 2012, BEHAV BRAIN RES, V229, P160, DOI 10.1016/j.bbr.2012.01.001
   Perry W, 2007, BIOL PSYCHIAT, V61, P482, DOI 10.1016/j.biopsych.2005.09.025
   Rousset CI, 2006, PEDIATR RES, V59, P428, DOI 10.1203/01.pdr.0000199905.08848.55
   Saadani-Makki F., 2008, AM J OBSTET GYNECOL, V199, P651
   Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
   Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
   Stephens BE, 2012, J DEV BEHAV PEDIATR, V33, P535, DOI 10.1097/DBP.0b013e31825fd0af
   Swerdlow NR, 2008, PSYCHOPHARMACOLOGY, V199, P331, DOI 10.1007/s00213-008-1072-4
   Umeda T, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015500
   Wass S, 2011, BRAIN COGNITION, V75, P18, DOI 10.1016/j.bandc.2010.10.005
   Wennekamp J, 2008, IMMUNOL REV, V225, P114, DOI 10.1111/j.1600-065X.2008.00673.x
   Whitaker A. H., 2011, PEDIATRICS, V1, P883
NR 50
TC 2
Z9 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0378-5866
EI 1421-9859
J9 DEV NEUROSCI-BASEL
JI Dev. Neurosci.
PY 2013
VL 35
IS 6
BP 504
EP 515
DI 10.1159/000355656
PG 12
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 268PW
UT WOS:000328184000006
PM 24246964
ER

PT J
AU Reissner, C
   Runkel, F
   Missler, M
AF Reissner, Carsten
   Runkel, Fabian
   Missler, Markus
TI Neurexins
SO GENOME BIOLOGY
LA English
DT Review
ID EXCITATORY SYNAPSE FORMATION; AUTISM SPECTRUM DISORDER; CELL-SURFACE
   PROTEINS; ALPHA-NEUREXINS; BETA-NEUREXINS; LIGAND-BINDING; CA2+
   CHANNELS; LNS DOMAIN; POSTSYNAPTIC DIFFERENTIATION; PRESYNAPTIC
   DIFFERENTIATION
AB The neurexin family of cell adhesion proteins consists of three members in vertebrates and has homologs in several invertebrate species. In mammals, each neurexin gene encodes an alpha-neurexin in which the extracellular portion is long, and a beta-neurexin in which the extracellular portion is short. As a result of alternative splicing, both major isoforms can be transcribed in many variants, contributing to distinct structural domains and variability. Neurexins act predominantly at the presynaptic terminal in neurons and play essential roles in neurotransmission and differentiation of synapses. Some of these functions require the formation of trans-synaptic complexes with postsynaptic proteins such as neuroligins, LRRTM proteins or cerebellin. In addition, rare mutations and copy-number variations of human neurexin genes have been linked to autism and schizophrenia, indicating that impairments of synaptic function sustained by neurexins and their binding partners may be relevant to the pathomechanism of these debilitating diseases.
C1 [Reissner, Carsten; Runkel, Fabian; Missler, Markus] Univ Munster, Inst Anat & Mol Neurobiol, D-48149 Munster, Germany.
RP Reissner, C (reprint author), Univ Munster, Inst Anat & Mol Neurobiol, D-48149 Munster, Germany.
EM creissn@uni-muenster.de; markus.missler@uni-muenster.de
FU Deutsche Forschungsgemeinschaft [SFB629, TPB11]
FX This work is supported by Deutsche Forschungsgemeinschaft grant number
   SFB629, TPB11 (MM).
CR Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Aoto J, 2013, CELL, V154, P75, DOI 10.1016/j.cell.2013.05.060
   Arac D, 2007, NEURON, V56, P992, DOI 10.1016/j.neuron.2007.12.002
   Arons MH, 2012, J NEUROSCI, V32, P14966, DOI 10.1523/JNEUROSCI.2215-12.2012
   Atasoy D, 2007, P NATL ACAD SCI USA, V104, P2525, DOI 10.1073/pnas.0611003104
   Banovic D, 2010, NEURON, V66, P724, DOI 10.1016/j.neuron.2010.05.020
   Beglopoulos V, 2005, MOL CELL BIOL, V25, P7278, DOI 10.1128/MCB.25.16.7278-7288.2005
   Berninghausen O, 2007, J NEUROCHEM, V103, P1855, DOI 10.1111/j.1471-4159.2007.04918.x
   Biederer T, 2000, J BIOL CHEM, V275, P39803, DOI 10.1074/jbc.C000656200
   Biswas S, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003542
   Bolliger MF, 2001, BIOCHEM J, V356, P581, DOI 10.1042/0264-6021:3560581
   Bottos A, 2011, CELL MOL LIFE SCI, V68, P2655, DOI 10.1007/s00018-011-0664-z
   Bottos A, 2009, P NATL ACAD SCI USA, V106, P20782, DOI 10.1073/pnas.0809510106
   Boucard AA, 2005, NEURON, V48, P229, DOI 10.1016/j.neuron.2005.08.026
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   Brodskiĭ L I, 1995, Biokhimiia, V60, P1221
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Chen F, 2011, STRUCTURE, V19, P779, DOI 10.1016/j.str.2011.03.012
   Chen X, 2008, NAT STRUCT MOL BIOL, V15, P50, DOI 10.1038/nsmb1350
   Chih B, 2004, HUM MOL GENET, V13, P1471, DOI 10.1093/hmg/ddh158
   Chih B, 2006, NEURON, V51, P171, DOI 10.1016/j.neuron.2006.06.005
   Chih B, 2005, SCIENCE, V307, P1324, DOI 10.1126/science.1107470
   Ching MSL, 2010, AM J MED GENET B, V153B, P937, DOI 10.1002/ajmg.b.31063
   Chubykin AA, 2007, NEURON, V54, P919, DOI 10.1016/j.neuron.2007.05.029
   Clarris HJ, 2002, INT J DEV BIOL, V46, P649
   Comoletti D, 2006, BIOCHEMISTRY-US, V45, P12816, DOI 10.1021/bi0614131
   Comoletti D, 2004, J NEUROSCI, V24, P4889, DOI 10.1523/JNEUROSCI.0468-04.2004
   Comoletti D, 2010, STRUCTURE, V18, P1044, DOI 10.1016/j.str.2010.06.005
   Dean C, 2003, NAT NEUROSCI, V6, P708, DOI 10.1038/nn1074
   de Wit J, 2009, NEURON, V64, P799, DOI 10.1016/j.neuron.2009.12.019
   Di Biase V, 2011, J NEUROSCI, V31, P13682, DOI 10.1523/JNEUROSCI.2300-11.2011
   Doherty JL, 2012, CLIN GENET, V81, P103, DOI 10.1111/j.1399-0004.2011.01773.x
   Dudanova I, 2006, J NEUROSCI, V26, P10599, DOI 10.1523/JNEUROSCI.1913-06.2006
   Dudanova I, 2007, J COMP NEUROL, V502, P261, DOI 10.1002/cne.21305
   Etherton M, 2011, P NATL ACAD SCI USA, V108, P13764, DOI 10.1073/pnas.1111093108
   Etherton MR, 2011, EMBO J, V30, P2908, DOI 10.1038/emboj.2011.182
   Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106
   Ey E, 2011, AUTISM RES, V4, P5, DOI 10.1002/aur.175
   Fabrichny IP, 2007, NEURON, V56, P979, DOI 10.1016/j.neuron.2007.11.013
   Fairless R, 2008, J NEUROSCI, V28, P12969, DOI 10.1523/JNEUROSCI.5294-07.2008
   Feinberg EH, 2008, NEURON, V57, P353, DOI 10.1016/j.neuron.2007.11.030
   Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017
   Fu Y, 2010, P NATL ACAD SCI USA, V107, P22699, DOI 10.1073/pnas.1011233108
   Futai K, 2007, NAT NEUROSCI, V10, P186, DOI 10.1038/nn1837
   Geppert M, 1998, J BIOL CHEM, V273, P1705, DOI 10.1074/jbc.273.3.1705
   Gjorlund MD, 2012, FASEB J, V26, P4174, DOI 10.1096/fj.11-202242
   Graf ER, 2004, CELL, V119, P1013, DOI 10.1016/j.cell.2004.11.035
   Graf ER, 2006, J NEUROSCI, V26, P4256, DOI 10.1523/JNEUROSCI.1253-05.2006
   Haklai-Topper L, 2011, GENE EXPR PATTERNS, V11, P144, DOI 10.1016/j.gep.2010.10.008
   Hata Y, 1996, J NEUROSCI, V16, P2488
   Ho A, 2008, J NEUROSCI, V28, P14392, DOI 10.1523/JNEUROSCI.2481-08.2008
   Hoppa MB, 2012, NATURE, V486, P122, DOI 10.1038/nature11033
   Hu ZT, 2012, SCIENCE, V337, P980, DOI 10.1126/science.1224896
   Hussain NK, 2005, SCIENCE, V307, P1207, DOI 10.1126/science.1110011
   ICHTCHENKO K, 1995, CELL, V81, P435, DOI 10.1016/0092-8674(95)90396-8
   Ichtchenko K, 1996, J BIOL CHEM, V271, P2676
   Iijima T, 2011, CELL, V147, P1601, DOI 10.1016/j.cell.2011.11.028
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Kaeser PS, 2011, CELL, V144, P282, DOI 10.1016/j.cell.2010.12.029
   Kang YH, 2008, J BIOL CHEM, V283, P2323, DOI 10.1074/jbc.M703957200
   Kattenstroth G, 2004, P NATL ACAD SCI USA, V101, P2607, DOI 10.1073/pnas.0308626100
   Keren H, 2010, NAT REV GENET, V11, P345, DOI 10.1038/nrg2776
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   Kirov G, 2009, SCHIZOPHRENIA BULL, V35, P851, DOI 10.1093/schbul/sbp079
   Knight D, 2011, MOL NEUROBIOL, V44, P426, DOI 10.1007/s12035-011-8213-1
   Ko J, 2009, NEURON, V64, P791, DOI 10.1016/j.neuron.2009.12.012
   Koehnke J, 2010, NEURON, V67, P61, DOI 10.1016/j.neuron.2010.06.001
   Koehnke J, 2008, STRUCTURE, V16, P410, DOI 10.1016/j.str.2007.12.024
   Koehnke J, 2008, P NATL ACAD SCI USA, V105, P1873, DOI 10.1073/pnas.0711701105
   Lee H, 2010, J NEUROSCI, V30, P11435, DOI 10.1523/JNEUROSCI.2946-10.2010
   Leone P, 2010, EMBO J, V29, P2461, DOI 10.1038/emboj.2010.123
   Levinson DF, 2012, AM J PSYCHIAT, V169, P963, DOI [10.1176/appl.ajp.2012.11091423, 10.1176/appi.ajp.2012.11091423]
   Li C, 2007, NEUROSCI LETT, V426, P192, DOI 10.1016/j.neulet.2007.08.065
   Matsuda K, 2011, EUR J NEUROSCI, V33, P1447, DOI 10.1111/j.1460-9568.2011.07638.x
   Maximov A, 1999, J BIOL CHEM, V274, P24453, DOI 10.1074/jbc.274.35.24453
   Miller MT, 2011, STRUCTURE, V19, P767, DOI 10.1016/j.str.2011.03.011
   Missler M, 1998, J NEUROSCI, V18, P3630
   Missler M, 1998, TRENDS GENET, V14, P20, DOI 10.1016/S0168-9525(97)01324-3
   Missler M, 2003, NATURE, V423, P939, DOI 10.1038/nature01755
   Missler M, 1998, J BIOL CHEM, V273, P34716, DOI 10.1074/jbc.273.52.34716
   Mosedale M, 2012, J BIOL CHEM, V287, P6350, DOI 10.1074/jbc.M111.299081
   Nam CI, 2005, P NATL ACAD SCI USA, V102, P6137, DOI 10.1073/pnas.0502038102
   Occhi G, 2002, BIOCHEM BIOPH RES CO, V298, P151, DOI 10.1016/S0006-291X(02)02403-8
   OCONNOR VM, 1993, FEBS LETT, V326, P255, DOI 10.1016/0014-5793(93)81802-7
   Owald D, 2012, NAT NEUROSCI, V15, P1219, DOI 10.1038/nn.3183
   Owen MJ, 2009, CURR OPIN GENET DEV, V19, P266, DOI 10.1016/j.gde.2009.02.008
   Patzke H, 2000, MOL CELL NEUROSCI, V15, P561, DOI 10.1006/mcne.2000.0853
   Petrenko AG, 1996, J NEUROSCI, V16, P4360
   Poulopoulos A, 2012, BIOCHEM J, V446, P321, DOI 10.1042/BJ20120808
   PUSCHEL AW, 1995, J NEUROSCI, V15, P2849
   Reichelt AC, 2012, NEUROPHARMACOLOGY, V62, P1519, DOI 10.1016/j.neuropharm.2011.01.024
   Reissner C, 2011, STRUCTURE, V19, P749, DOI 10.1016/j.str.2011.05.005
   Reissner C, 2008, P NATL ACAD SCI USA, V105, P15124, DOI 10.1073/pnas.0801639105
   Rissone A, 2007, MOL BIOL EVOL, V24, P236, DOI 10.1093/molbev/msl147
   Rowen L, 2002, GENOMICS, V79, P587, DOI 10.1006/geno.2002.6734
   Rozic G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018579
   Rozic-Kotliroff G, 2007, BIOCHEM BIOPH RES CO, V352, P226, DOI 10.1016/j.bbrc.2006.11.008
   Rudenko G, 2001, TRENDS BIOCHEM SCI, V26, P363, DOI 10.1016/S0968-0004(01)01832-1
   Rudenko G, 1999, CELL, V99, P93, DOI 10.1016/S0092-8674(00)80065-3
   Scheiffele P, 2000, CELL, V101, P657, DOI 10.1016/S0092-8674(00)80877-6
   Shapiro-Reznik M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037894
   Shen KC, 2008, STRUCTURE, V16, P422, DOI 10.1016/j.str.2008.01.005
   Siddiqui TJ, 2010, J NEUROSCI, V30, P7495, DOI 10.1523/JNEUROSCI.0470-10.2010
   Sons MS, 2006, NEUROSCIENCE, V138, P433, DOI 10.1016/j.neuroscience.2005.11.040
   Stoltenberg Scott F, 2011, Drug Alcohol Depend, V119, pe31, DOI 10.1016/j.drugalcdep.2011.05.025
   Striegel AR, 2012, J NEUROSCI, V32, P1253, DOI 10.1523/JNEUROSCI.4652-11.2012
   Suckow AT, 2008, ENDOCRINOLOGY, V149, P6006, DOI 10.1210/en.2008-0274
   Suckow AT, 2012, J BIOL CHEM, V287, P19816, DOI 10.1074/jbc.M111.280537
   Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456
   USHKARYOV YA, 1994, J BIOL CHEM, V269, P11987
   Sugita S, 2001, J CELL BIOL, V154, P435, DOI 10.1083/jcb.200105003
   Sun MK, 2011, J NEUROSCI, V31, P687, DOI 10.1523/JNEUROSCI.3854-10.2011
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Tabuchi K, 2002, GENOMICS, V79, P849, DOI 10.1006/geno.2002.6780
   Tanaka H, 2012, CELL REPORTS, V2, P101, DOI 10.1016/j.celrep.2012.06.009
   Tanaka H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019411
   Taniguchi H, 2007, J NEUROSCI, V27, P2815, DOI 10.1523/JNEUROSCI.0032-07.2007
   Uemura T, 2010, CELL, V141, P1068, DOI 10.1016/j.cell.2010.04.035
   ULLRICH B, 1995, NEURON, V14, P497, DOI 10.1016/0896-6273(95)90306-2
   USHKARYOV YA, 1992, SCIENCE, V257, P50, DOI 10.1126/science.1621094
   USHKARYOV YA, 1993, P NATL ACAD SCI USA, V90, P6410, DOI 10.1073/pnas.90.14.6410
   Vaags AK, 2012, AM J HUM GENET, V90, P133, DOI 10.1016/j.ajhg.2011.11.025
   Varoqueaux F, 2006, NEURON, V51, P741, DOI 10.1016/j.neuron.2006.09.003
   Varoqueaux F, 2004, EUR J CELL BIOL, V83, P449, DOI 10.1078/0171-9335-00410
   Wizemann H, 2003, J MOL BIOL, V332, P635, DOI 10.1016/S0022-2836(03)00848-9
   Yasumura M, 2012, J NEUROCHEM, V121, P705, DOI 10.1111/j.1471-4159.2011.07631.x
   Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
   Yoshida-Moriguchi T, 2010, SCIENCE, V327, P88, DOI 10.1126/science.1180512
   Zeng XK, 2007, FEBS LETT, V581, P2509, DOI 10.1016/j.febslet.2007.04.068
   Zhang C, 2010, NEURON, V66, P403, DOI 10.1016/j.neuron.2010.04.008
   Zhang WQ, 2005, J NEUROSCI, V25, P4330, DOI 10.1523/JNEUROSCI.0497-05.2005
   Zhou HY, 2005, J BIOL CHEM, V280, P13841, DOI 10.1074/jbc.M411065200
NR 132
TC 8
Z9 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1465-6906
EI 1474-760X
J9 GENOME BIOL
JI Genome Biol.
PY 2013
VL 14
IS 9
AR 213
DI 10.1186/gb-2013-14-9-213
PG 15
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 268UI
UT WOS:000328195700017
PM 24083347
ER

PT J
AU Ro, M
   Won, S
   Kang, H
   Kim, SY
   Lee, SK
   Nam, M
   Bang, HJ
   Yang, JW
   Choi, KS
   Kim, SK
   Chung, JH
   Kwack, K
AF Ro, MyungJa
   Won, SeongSik
   Kang, HyunJun
   Kim, Su-Yeon
   Lee, Seung Ku
   Nam, Min
   Bang, Hee Jung
   Yang, Jae Won
   Choi, Kyung-Sik
   Kim, Su Kang
   Chung, Joo-Ho
   Kwack, KyuBum
TI Association of the FGA and SLC6A4 Genes with Autistic Spectrum Disorder
   in a Korean Population
SO NEUROPSYCHOBIOLOGY
LA English
DT Article
DE Autism spectrum disorder; Polymorphism; Childhood Autism Rating Scale;
   SLC6A4; FGA
ID SEROTONIN TRANSPORTER GENE; MYOCARDIAL-INFARCTION; BRAIN-DEVELOPMENT;
   POLYMORPHISMS; HAPLOTYPES; FIBRINOGEN; LINKAGE; MICE; HYPERSEROTONEMIA;
   VARIANTS
AB Background: Autism spectrum disorder (ASD) is a neurobiological disorder characterized by distinctive impairments in cognitive function, language, and behavior. Linkage and population studies suggest a genetic association between solute carrier family 6 member 4 (SLC6A4) variants and ASD. Method: Logistic regression was used to identify associations between single-nucleotide polymorphisms (SNPs) and ASD with 3 alternative models (additive, dominant, and recessive). Linear regression analysis was performed to determine the influence of SNPs on Childhood Autism Rating Scale (CARS) scores as a quantitative phenotype. Results: In the present study, we examined the associations of SNPs in the SLC6A4 gene and the fibrinogen alpha chain (FGA) gene. Logistic regression analysis showed a significant association between the risk of ASD and rs2070025 and rs2070011 in the FGA gene. The gene-gene interaction between SLC6A4 and FGA was not significantly associated with ASD susceptibility. However, polymorphisms in both SLC6A4 and the FGA gene significantly affected the symptoms of ASD. Conclusion: Our findings indicate that FGA and SLC6A4 gene interactions may contribute to the phenotypes of ASD rather than the incidence of ASD. (C) 2013 S. Karger AG, Basel
C1 [Ro, MyungJa; Won, SeongSik; Kang, HyunJun; Kim, Su-Yeon; Lee, Seung Ku; Kwack, KyuBum] CHA Univ, Coll Life Sci, Dept Biomed Sci, Songnam, South Korea.
   [Nam, Min] Ewha Womans Univ, Seoul Metropolitan Childrens Hosp, Dept Psychiat, Seoul, South Korea.
   [Bang, Hee Jung] Ewha Womans Univ, Coll Social Sci, Dept Psychol, Seoul, South Korea.
   [Kim, Su Kang; Chung, Joo-Ho] Kyung Hee Univ, Sch Med, Kohwang Med Res Inst, Seoul, South Korea.
   [Yang, Jae Won] Korea Univ, Ansan Hosp, Coll Med, Dept Psychiat, Ansan, South Korea.
   [Choi, Kyung-Sik] Joongbu Univ, Dept Elementary Special Educ, Coll Social Sci, Chungnam, South Korea.
RP Kwack, K (reprint author), CHA Univ, Coll Life Sci, Dept Biomed Sci, 222 Yatapdong, Songnam 463836, Gyeonggido, South Korea.
EM kbkwack@cha.ac.kr
FU Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of
   Korea [A040002]
FX This study was supported by a grant from the Korea Health 21 R&D
   Project, Ministry of Health and Welfare, Republic of Korea (A040002).
CR Anderson GM, 2002, J AM ACAD CHILD PSY, V41, P1513, DOI 10.1097/01.CHI.0000024874.60748.28
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Ben-David E, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002556
   Carneiro AMD, 2008, J CLIN INVEST, V118, P1544, DOI 10.1172/JCI33374
   Casey JP, 2012, HUM GENET, V131, P565, DOI 10.1007/s00439-011-1094-6
   Cho IH, 2007, BRAIN RES, V1139, P34, DOI 10.1016/j.brainres.2007.01.002
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Cook EH, 1997, MOL PSYCHIATR, V2, P247
   Costa E, 2008, METABOLISM S2, V57, pS40
   Coutinho AM, 2004, MOL PSYCHIATR, V9, P264, DOI 10.1038/sj.mp.4001409
   Coutinho AM, 2007, HUM GENET, V121, P243, DOI 10.1007/s00439-006-0301-3
   Ellis SJ, 2010, CELL TISSUE RES, V339, P121, DOI 10.1007/s00441-009-0828-4
   Faras H, 2010, ANN SAUDI MED, V30, P295, DOI 10.4103/0256-4947.65261
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559
   Gingrich JA, 2001, PSYCHOPHARMACOLOGY, V155, P1, DOI 10.1007/s002130000573
   Holmes A, 2003, GENES BRAIN BEHAV, V2, P365, DOI 10.1046/j.1601-183X.2003.00050.x
   Jacquemin B, 2008, J AM COLL CARDIOL, V52, P941, DOI 10.1016/j.jacc.2008.06.016
   Lazary J, 2008, BIOL PSYCHIAT, V64, P498, DOI 10.1016/j.biopsych.2008.03.030
   Mannila MN, 2007, J INTERN MED, V261, P138, DOI 10.1111/j.1365-2796.2006.01749.x
   Marioni RE, 2011, BEHAV GENET, V41, P691, DOI 10.1007/s10519-011-9449-2
   McCauley JL, 2004, AM J MED GENET B, V127B, P104, DOI 10.1002/ajmg.b.20151
   Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0
   Rafnsson SB, 2007, J AM GERIATR SOC, V55, P700, DOI 10.1111/j.1532-5415.2007.01158.x
   Rivas G, 1996, J MOL RECOGNIT, V9, P31, DOI 10.1002/(SICI)1099-1352(199601)9:1<31::AID-JMR237>3.3.CO;2-F
   Seneviratne C, 2009, ALCOHOL CLIN EXP RES, V33, P332, DOI 10.1111/j.1530-0277.2008.00837.x
   Sodhi MSK, 2004, INT REV NEUROBIOL, V59, P111
   Su SY, 2009, CIRC-CARDIOVASC GENE, V2, P614, DOI 10.1161/CIRCGENETICS.109.870386
   Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648
   Taniai H, 2008, AM J MED GENET B, V147B, P844, DOI 10.1002/ajmg.b.30740
   Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109
   Weiss LA, 2006, HUM GENET, V120, P93, DOI 10.1007/s00439-006-0196-z
   Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
   Whitaker-Azmitia PM, 2005, INT J DEV NEUROSCI, V23, P75, DOI 10.1016/j.ijdevneu.2004.07.022
   Wray NR, 2009, BIOL PSYCHIAT, V66, P468, DOI 10.1016/j.biopsych.2009.04.030
   Wu SP, 2005, NEUROSCI LETT, V381, P1, DOI 10.1016/j.neulet.2005.01.073
   Yoo HJ, 2009, KOREAN J BIOL PSYCHI, V16, P121
   Zafeiriou DI, 2009, CURR NEUROPHARMACOL, V7, P150, DOI 10.2174/157015909788848848
NR 39
TC 1
Z9 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0302-282X
EI 1423-0224
J9 NEUROPSYCHOBIOLOGY
JI Neuropsychobiology
PY 2013
VL 68
IS 4
BP 212
EP 220
DI 10.1159/000355299
PG 9
WC Neurosciences; Psychiatry; Psychology
SC Neurosciences & Neurology; Psychiatry; Psychology
GA 270IK
UT WOS:000328311900004
PM 24192574
ER

PT J
AU Dudova, I
   Hrdlicka, M
AF Dudova, Iva
   Hrdlicka, Michal
TI Olfactory functions are not associated with autism severity in autism
   spectrum disorders
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE autism spectrum disorders; psychopathology; Sniffin' Sticks; odor
   threshold; odor identification; odor pleasantness
ID ODOR DISCRIMINATION; EEG ABNORMALITIES; CHILDHOOD AUTISM; CHILDREN;
   IDENTIFICATION; CLASSIFICATION; ABILITY
AB Background: Changes in olfactory functions have been found in many neurodegenerative and psychiatric disorders, including autism spectrum disorders (ASDs). The aim of the present study was to evaluate the relationship between olfactory functions (odor-detection thresholds, odor identification, and odor preference) and autism severity and sensory-related behavior in children and adolescents with ASD.
   Subjects and methods: Our sample consisted of 35 high-functioning patients with ASD (mean age 10.8 +/- 3.6 years, 31 boys). Olfactory testing (threshold and identification) used the Sniffin' Sticks test. Odor pleasantness was assessed on a 5-point scale using the Identification part of the Sniffin' Sticks test. The severity of autistic psychopathology was measured using the Childhood Autism Rating Scale (CARS).
   Results: Using Spearman's correlation, we found no significant correlations between autism severity (as expressed by total CARS score) and odor-detection thresholds (R=0.144, P=0.409), odor identification (R=0.07, P=0.966), or odor pleasantness (R=-0.046, P=0.794). There was also no significant relationship between CARS item 9 ("Taste, smell, and touch response and use") and odor-detection thresholds (R=0.170, P=0.330), odor identification (R=0.282, P=0.100), or odor pleasantness (R=0.017, P=0.923).
   Conclusion: We did not find any significant relationship between the severity of autistic psychopathology and olfactory functions.
C1 [Dudova, Iva; Hrdlicka, Michal] Univ Hosp Motol, Dept Child Psychiat, Prague, Czech Republic.
RP Dudova, I (reprint author), Charles Univ Prague, Dept Child Psychiat, Fac Med 2, Univ Hosp Motol, 84 5 Uvalu, Prague 15006, Czech Republic.
EM iva.dudova@lfmotol.cuni.cz
FU Ministry of Education, Youth and Sports, Czech Republic [COST LD11028];
   Ministry of Health, Czech Republic (conceptual development of research
   organization, University Hospital Motol, Prague, Czech Republic)
   [00064203]
FX This study was supported by the Ministry of Education, Youth and Sports,
   Czech Republic (research grant COST LD11028) and by the Ministry of
   Health, Czech Republic (conceptual development of research organization,
   University Hospital Motol, Prague, Czech Republic 00064203). The authors
   would like to thank Thomas Secrest, MSc for his assistance with the
   English version of the manuscript.
CR Bennetto L, 2007, BIOL PSYCHIAT, V62, P1015, DOI 10.1016/j.biopsych.2007.04.019
   Ben Shalom D, 2006, J AUTISM DEV DISORD, V36, P395, DOI 10.1007/s10803-006-0077-2
   Brewer WJ, 2008, RES AUTISM SPECT DIS, V2, P612, DOI 10.1016/j.rasd.2008.01.003
   Brewer WJ, 2006, OLFACTION AND THE BRAIN, P1, DOI 10.1017/CBO9780511543623
   Chiappedi M, 2010, ITAL J PEDIATR, V36, DOI 10.1186/1824-7288-36-10
   Dudova I, 2011, EUR CHILD ADOLES PSY, V20, P333, DOI 10.1007/s00787-011-0177-1
   Dunn W, 2002, INFANT TODDLER SENSO
   Ekinci O, 2010, EPILEPSY BEHAV, V17, P178, DOI 10.1016/j.yebeh.2009.11.014
   Guerini FR, 2011, PHARMACOL RES, V64, P283, DOI 10.1016/j.phrs.2011.03.015
   Hrdlicka M, 2004, STUD PSYCHOL, V46, P229
   Hrdlicka M, 2011, J AUTISM DEV DISORD, V41, P524, DOI 10.1007/s10803-010-1084-x
   Hummel T, 1997, CHEM SENSES, V22, P39, DOI 10.1093/chemse/22.1.39
   Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
   Kobal G, 2000, EUR ARCH OTO-RHINO-L, V257, P205, DOI 10.1007/s004050050223
   Kulisek R, 2008, NEUROENDOCRINOL LETT, V29, P512
   Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   May T, 2011, J AUTISM DEV DISORD, V41, P837, DOI 10.1007/s10803-010-1101-0
   Schecklmann M, 2013, J NEURAL TRANSM, V120, P121, DOI 10.1007/s00702-012-0855-2
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Suzuki Y, 2003, J NEUROPSYCH CLIN N, V15, P105, DOI 10.1176/appi.neuropsych.15.1.105
   Tavassoli T, 2012, J AUTISM DEV DISORD, V42, P905, DOI 10.1007/s10803-011-1321-y
   Vodicka J, 2007, RHINOLOGY, V45, P164
   Hartley-McAndrew Michelle, 2010, Neurol Int, V2, pe10, DOI 10.4081/ni.2010.e10
   World Health Organization, 1992, INT CLASSIFICATION D
NR 25
TC 3
Z9 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1176-6328
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2013
VL 9
BP 1847
EP 1850
DI 10.2147/NDT.S54893
PG 4
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 262MN
UT WOS:000327739600001
PM 24399878
ER

PT J
AU Lopes, DC
   Del Prette, ZAP
   Del Prette, A
AF Lopes, Daniele Carolina
   Pereira Del Prette, Zilda Aparecida
   Del Prette, Almir
TI Multimedia Resources to Teach Social Skills to Children with Low
   Academic Achievement
SO PSICOLOGIA-REFLEXAO E CRITICA
LA Portuguese
DT Article
DE Low academic performance; social skills; audiovisual resources
ID LEARNING-DISABILITIES; STUDENTS; BEHAVIOR; INTERVENTIONS; ADOLESCENTS;
   COMPETENCE; AUTISM
AB Social skills programs using audiovisual or multimedia resources may help to overcome social skills deficits and low academic performance. This study evaluated the effects of a program based on video vignettes of RMHSC-Del-Prette on social skills repertoire and academic performance of children with low academic achievement. Under an experimental design, 14 children were assessed with the Social Skills Rating System before and after interventions composed by 22 sessions. Experimental Group showed significantly higher gains than the Control Group in social skills and academic performance. The usefulness of RMHSC-Del-Prette in social skills programs and issues related to its dissemination in the school context are discussed.
C1 [Lopes, Daniele Carolina; Pereira Del Prette, Zilda Aparecida; Del Prette, Almir] Univ Fed Sao Carlos, BR-13565905 Sao Carlos, SP, Brazil.
RP Lopes, DC (reprint author), Univ Fed Sao Carlos, Ctr Educ & Ciencias Humanas, Lab Interacao Social, Dept Psicol,Grp RIHS, Rd Washington Luiz,Km 235, BR-13565905 Sao Carlos, SP, Brazil.
EM danielecalopes@hotmail.com
CR Arnold DH, 2012, EARLY CHILD RES Q, V27, P376, DOI 10.1016/j.ecresq.2011.12.009
   August G., 2001, J CONSULT CLIN PSYCH, V69, P641
   Bandeira Marina, 2006, Estud. psicol. (Natal), V11, P199, DOI 10.1590/S1413-294X2006000200009
   Bandeira M., 2006, INTERACAO PSICOLOGIA, V10, P53
   Bandeira Marina, 2009, Psic.: Teor. e Pesq., V25, P271, DOI 10.1590/S0102-37722009000200016
   Barreto S. O., 2011, PSICO PORTO ALEGRE, V42, P503
   Brigman G., 2007, PROFESSIONAL SCH COU, V10, P279
   Caprara GV, 2000, PSYCHOL SCI, V11, P302, DOI 10.1111/1467-9280.00260
   Cartledge G, 2005, LEARN DISABILITY Q, V28, P179, DOI 10.2307/1593623
   Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
   Cia Fabiana, 2009, Estud. psicol. (Campinas), V26, P45, DOI 10.1590/S0103-166X2009000100005
   Comodo C. N., 2011, PSICOLOGIA TEORIA PR, V13, P34
   Del Prette A., 2005, PSICOLOGIA HABILIDAD
   Del Prette A., 2003, HABILIDADES SOCIAIS, P83
   Del Prette A, 2005, SISTEMA MULTIMIDIA H
   Del Prette A, 2006, ESTUDOS HABILIDADES, P47
   DelPrette A., 2001, PSICOLOGIA RELACOES
   Del Prette ZAP, 2012, SCHOOL PSYCHOL INT, V33, P615, DOI 10.1177/0020715211430373
   Dilworth JE, 2002, J SCHOOL PSYCHOL, V40, P329
   Diperna JC, 2006, PSYCHOL SCHOOLS, V43, P7, DOI 10.1002/pits.20125
   Feitosa F. B., 2011, ESTUDOS PESQUISAS PS, V11, P442
   Gresham F. M., 2007, SOCIAL SKILLS IMPROV
   Gresham F. M., 1990, SOCIAL SKILLS RATING
   Gresham F. M., 2009, PSICOLOGIA HABILIDAD, P17
   Gresham FM, 2004, SCHOOL PSYCHOL REV, V33, P326
   Hennessey BA, 2007, J SCHOOL PSYCHOL, V45, P349, DOI 10.1016/j.jsp.2006.11.007
   Herrera G, 2008, AUTISM, V12, P143, DOI 10.1177/1362361307086657
   Instituto Brasileiro de Opiniao Publica e Estatistica & Associacao Brasileira de Empresas de Pesquisa, 2005, CRIT CLASS EC BRAS
   Kavale KA, 2004, LEARN DISABILITY Q, V27, P31, DOI 10.2307/1593630
   Kilian J. M, 2011, IMPROVING SCH, V14, P65
   Kirner C., 2006, FUNDAMENTOS TECNOLOG, P2
   Lane KL, 2006, EXCEPT CHILDREN, V72, P153
   Malecki C. K., 2002, SCHOOL PSYCHOL QUART, V17, P1, DOI DOI 10.1521/SCPQ.17.1.1.19902
   Meier C. R., 2006, ED TREATMENT CHILDRE, V29, P409
   Miles SB, 2006, CHILD DEV, V77, P103, DOI 10.1111/j.1467-8624.2006.00859.x
   Molina Renata Cristina Moreno, 2006, Psico-USF, V11, P53, DOI 10.1590/S1413-82712006000100007
   Murta SG, 2007, PSICOL-REFLEX CRIT, V20, P1, DOI 10.1590/S0102-79722007000100002
   Park KM, 2011, PSYCHIAT RES, V189, P166, DOI 10.1016/j.psychres.2011.04.003
   Parsons LD., 2006, TEACHING EXCEPTIONAL, V39, P32
   Parsons S, 2006, COMPUT EDUC, V47, P186, DOI 10.1016/j.compedu.2004.10.003
   Ray CE, 2006, SCHOOL PSYCHOL REV, V35, P493
   Reed FDD, 2011, RES AUTISM SPECT DIS, V5, P1003, DOI 10.1016/j.rasd.2011.01.022
   Samadzadeh M., 2011, PROCEDIA SOCIAL BEHA, V28, P286
   Santos P. L., 2006, ESTUD PSICOL-NATAL, V11, P101
   Stein LM, 1994, TDE TESTE DESEMPENHO
   WENTZEL KR, 1991, CHILD DEV, V62, P1066, DOI 10.1111/j.1467-8624.1991.tb01589.x
NR 46
TC 0
Z9 0
PU UNIV FEDERAL RIO GRANDE SUL
PI PORTO ALEGRE RS
PA INST PSICOLOGIA, PPG EM PSICOLOGIA DA UFRGS, RUA RAMIRO BARCELOS 2600,
   PORTO ALEGRE RS, 90035-003, BRAZIL
SN 0102-7972
J9 PSICOL-REFLEX CRIT
JI Psicol.-Reflex. Crit.
PY 2013
VL 26
IS 3
BP 451
EP 458
PG 8
WC Psychology, Multidisciplinary
SC Psychology
GA 262CE
UT WOS:000327710900004
ER

PT J
AU Arthanat, S
   Curtin, C
   Knotak, D
AF Arthanat, Sajay
   Curtin, Christine
   Knotak, David
TI Comparative Observations of Learning Engagement by Students With
   Developmental Disabilities Using an iPad and Computer: A Pilot Study
SO ASSISTIVE TECHNOLOGY
LA English
DT Article
DE assistive technology; developmental disability; education; iPad; single
   subject design
AB This study examined the use of the Apple iPad for learning by children with developmental disabilities (DD), including those on the autism spectrum. A single case design was used to record the participation of four students with DD when taught with their standard computer at baseline, followed by the introduction of the iPad. A six-component participation scale was developed to quantify observations of these students during the learning sessions. Visual analysis of data indicated no differences in participation with the iPad as compared to the computer for three of the four subjects. One subject appeared to have notably higher participation with the iPad. Individual variations were identified in each student along with some common concerns with attention, task persistence, and goal directed behavior with use of the iPad. Student academic scores improved during the course of iPad use. Nevertheless, the findings drawn from this pilot study do not justify the use of the iPad over the computer (and vice versa) for achieving academic goals in students with DD. The need to document best practices and barriers in use of emerging touch-tablet devices to support individualized education was clearly evident.
C1 [Arthanat, Sajay; Curtin, Christine] Univ New Hampshire, Coll Hlth & Human Serv, Durham, NH 03824 USA.
   [Knotak, David] Crotched Mt Rehabil Ctr, Greenfield, NH USA.
RP Arthanat, S (reprint author), Univ New Hampshire, Coll Hlth & Human Serv, 4 Lib Way,Hewitt Hall, Durham, NH 03824 USA.
EM sajay.arthanat@unh.edu
CR Akhutina T, 2003, DISABIL REHABIL, V25, P1361, DOI 10.1080/09638280310001616358
   Betz Goose K E, 1998, MANUAL FACILITATE CL
   Buchanan R., 2010, ACCESSIBILITY IPAD 1
   Durfee JL, 1999, AM J OCCUP THER, V53, P214
   Flores M, 2012, AUGMENT ALTERN COMM, V28, P74, DOI 10.3109/07434618.2011.644579
   Gordon M., 2011, STAMFORD ADVOCA 0208
   Hager E. B., 2010, NY TIMES
   Handley-More D, 2003, AM J OCCUP THER, V57, P139
   Hu W., 2011, NY TIMES
   Jacklin A, 2005, BRIT J SPECIAL ED, V32, P202, DOI 10.1111/j.1467-8578.2005.00398.x
   Jowett EL, 2012, DEV NEUROREHABIL, V15, P304, DOI 10.3109/17518423.2012.682168
   Kratochwill T. R., 2010, SINGLE CASE DESIGNS
   Learmonth M, 2010, AD MARKETING IN 0607
   McDonough C., 2006, RES DEV DISABIL, V27, P175
   Mott Michael S, 2010, Disabil Rehabil Assist Technol, V5, P94, DOI 10.3109/17483100903387291
   Shimizu H, 2010, RES DEV DISABIL, V31, P1448, DOI 10.1016/j.ridd.2010.06.013
   Sughrue K. M, 2011, 60 MINUTES
   U. S. Census Bureau, 2006, AM COMM SURV
   U.S. Department of Education, 2004, BUILD LEG IDEA 2004
   U.S. Department of Health and Human Services Centers for Disease Control and Prevention, 2011, AUT SPECTR DIS DAT S
   World Health Organisation, 2001, INT CLASS FUNCT DIS
NR 21
TC 0
Z9 0
PU R E S N A PRESS
PI ARLINGTON
PA 1700 MOORE ST, STE 1540, ARLINGTON, VA 22209-1903 USA
SN 1040-0435
EI 1949-3614
J9 ASSIST TECHNOL
JI Assist. Technol.
PY 2013
VL 25
IS 4
BP 204
EP 213
DI 10.1080/10400435.2012.761293
PG 10
WC Rehabilitation
SC Rehabilitation
GA 257OM
UT WOS:000327394300003
PM 24620703
ER

PT J
AU Dudova, I
   Hrdlicka, M
AF Dudova, Iva
   Hrdlicka, Michal
TI Use of ADI-R and ADOS in diagnostics of autism
SO CESKOSLOVENSKA PSYCHOLOGIE
LA Czech
DT Article
DE autism spectrum disorders; diagnosis; ADI-R; ADOS
ID SPECTRUM DISORDERS; OBSERVATION SCHEDULE; CHILDHOOD AUTISM;
   RATING-SCALE; COMBINING INFORMATION; MULTIPLE SOURCES; INTERVIEW;
   CHILDREN; CLASSIFICATION
AB The authors discuss two "gold standard" methods for the diagnosis of autism spectrum disorders: ADI-R (Autism Diagnostic Interview-Revised) and ADOS (Autism Diagnostic Observation Schedule), and review comparative studies that evaluate the methods. Some of the studies found the instruments to be diagnostically equivalent, other studies slightly favored ADOS. Sensitivity of both methods was high even when used alone. However, the combined use of ADI-R and ADOS led to higher diagnostic specificity. The authors also present two cases describing the parallel clinical use of ADI-R and ADOS as part of the diagnosis of two boys aged 8.8 and 4.2 years, respectively. Both cases effectively demonstrate the following theoretical assumption: whereas the reliability of both methods is comparable under optimal conditions, the use of ADI-R is significantly limited in cases when the cooperation of the parent(s) or caregiver is unreliable, limited, or impossible. In such cases, examination using ADOS is preferred.
C1 [Dudova, Iva; Hrdlicka, Michal] LF UK, Detska Psychiat Klin 2, FN Motol, Prague, Czech Republic.
RP Dudova, I (reprint author), Detska Psychiat Klin, V Uvalu 84, Prague 15006 5, Motol, Czech Republic.
EM iva.dudova@lfmotol.cuni.cz
CR Beranova S, 2012, CESK PSYCHOL, V56, P167
   Chamak B, 2008, PSYCHOTHER PSYCHOSOM, V77, P271, DOI 10.1159/000140086
   Buitelaar JK, 1999, J AUTISM DEV DISORD, V29, P33, DOI 10.1023/A:1025966532041
   Cicchetti DV, 2008, J AUTISM DEV DISORD, V38, P764, DOI 10.1007/s10803-007-0448-3
   de Bildt A, 2004, J AUTISM DEV DISORD, V34, P129
   Gray KM, 2008, J AUTISM DEV DISORD, V38, P657, DOI 10.1007/s10803-007-0432-y
   Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
   Hrdlicka M, 2011, CESK PSYCHOL, V55, P82
   Ivar Lovaas O., 1987, J CONSULT CLIN PSYCH, V55, P3, DOI DOI 10.1037//0022-006X.55.13
   Kim SH, 2012, J CHILD PSYCHOL PSYC, V53, P143, DOI 10.1111/j.1469-7610.2011.02458.x
   Le Couteur A, 2008, J AUTISM DEV DISORD, V38, P362, DOI 10.1007/s10803-007-0403-3
   Lord C., 1997, AUTISM PERVASIVE DEV, P460
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Papanikolaou K, 2009, J AUTISM DEV DISORD, V39, P414, DOI 10.1007/s10803-008-0639-6
   Pilowsky T, 1998, J AUTISM DEV DISORD, V28, P143, DOI 10.1023/A:1026092632466
   Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
   Rutter M., 2002, CHILD ADOLESCENT PSY
   RUTTER M, 1970, SEMIN PSYCHIAT, V2, P435
   Saemundsen E, 2003, J AUTISM DEV DISORD, V33, P319, DOI 10.1023/A:1024410702242
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
NR 21
TC 0
Z9 0
PU ACADEMIA
PI PRAGUE 1
PA PUBL HOUSE CZECH ACAD SCI VODICKOVA 40, PRAGUE 1 112 29, CZECH REPUBLIC
SN 0009-062X
EI 1804-6436
J9 CESK PSYCHOL
JI Cesk. Psychol.
PY 2013
VL 57
IS 5
BP 488
EP 495
PG 8
WC Psychology, Multidisciplinary
SC Psychology
GA 252IW
UT WOS:000326999400007
ER

PT J
AU Leeds, CA
   Jensvold, ML
AF Leeds, Charles Austin
   Jensvold, Mary Lee
TI The communicative functions of five signing chimpanzees (Pan
   troglodytes)
SO PRAGMATICS & COGNITION
LA English
DT Article
DE American Sign Language; Chimpanzee; communicative function;
   cross-fostered
ID CROSS-FOSTERED CHIMPANZEES; YOUNG-CHILDREN; INTENTIONS; LANGUAGE; AGE;
   UTTERANCES; PHYLOGENY; PROFILES; SPEECH; AUTISM
AB Speech act theory describes units of language as acts which function to change the behavior or beliefs of the partner. Therefore, with every utterance an individual seeks a communicative goal that is the underlying motive for the utterance's production; this is the utterance's function. Studies of deaf and hearing human children classify utterances into categories of communicative function. This study classified signing chimpanzees' utterances into the categories used in human studies. The chimpanzees utilized all seven categories of communicative functions and used them in ways that resembled human children. The chimpanzees' utterances functioned to answer questions, request objects and actions, describe objects and events, make statements about internal states, accomplish tasks such as initiating games, protest interlocutor behavior, and as conversational devices to maintain and initiate conversation.
C1 [Leeds, Charles Austin] Case Western Reserve Univ, Cleveland Metropk Zoo, Cleveland, OH 44109 USA.
   [Jensvold, Mary Lee] Cent Washington Univ, Ellensburg, WA USA.
RP Leeds, CA (reprint author), Case Western Reserve Univ, Cleveland Metropk Zoo, 3900 Wildlife Way, Cleveland, OH 44109 USA.
EM Charles.austin.leeds@gmail.com; Jensvold@cwu.edu
CR Akhtar N., 2007, SOCIOEMOTIONAL DEV T, P201
   Aureli T, 2009, COGNITIVE DEV, V24, P1, DOI 10.1016/j.cogdev.2008.07.003
   Austin J., 1962, DO THINGS WORDS
   Barachetti C, 2010, EARLY EDUC DEV, V21, P595, DOI 10.1080/10409280903150336
   Becker J. A., 1982, LANGUAGE DEV LANGUAG, V2, P1
   Bodamer MD, 2002, J COMP PSYCHOL, V116, P12, DOI 10.1037//0735-7036.116.1.12
   Bodamer MD, 1994, HUMAN EVOLUTION, V9, P281, DOI DOI 10.1007/BF02435515
   Brown R., 1973, 1 LANGUAGE EARLY STA
   Bruce S. M., 2004, RE VIEW, V36, P81, DOI 10.3200/REVU.36.2.81-92
   CARPENTER RL, 1983, LANG SPEECH, V26, P101
   COGGINS TE, 1987, J SPEECH HEAR DISORD, V52, P44
   Covington V. C., 1973, SIGN LANGUAGE STUDIE, V2, P29
   DAY PS, 1986, J COMMUN DISORD, V19, P367, DOI 10.1016/0021-9924(86)90027-4
   Dore J., 1973, ANN NY ACAD SCI, V98, P456
   Dore J., 1977, DISCOURSE PRODUCTION, V1, P227
   Dore J., 1977, CHILD DISCOURSE, P139
   Dore J., 1975, J CHILD LANG, V2, P21
   DORE J, 1974, J PSYCHOLINGUIST RES, V3, P343, DOI 10.1007/BF01068169
   DRUMM P, 1986, AM J PSYCHOL, V99, P1, DOI 10.2307/1422301
   Ervin-Tripp Suzanne, 1977, CHILD DISCOURSE, P165
   FLAX J, 1991, J CHILD LANG, V18, P3
   FOUTS DH, 1994, NATO ADV SCI INST SE, V78, P271
   Fouts R. S., 1989, TEACHING SIGN LANGUA, P281
   Fouts R. S., 1984, SIGN LANGUAGE STUDIE, V42, P1
   Fouts R. S., 1987, COGNITION LANGUAGE C, V2, P57
   Fouts R. S., 1989, HOUSING CARE PSYCHOL, P376
   Fouts R. S., 1975, HOMINISATION VERHALT, P137
   Fouts R. S., 1976, SIGN LANG STUD, V13, P319
   Fouts Roger S., 1993, GREAT APE PROJECT, P28
   Fouts R.S., 1989, P293
   FOUTS RS, 1982, CHILD NURTURANCE, V3, P159
   FURROW D, 1984, CHILD DEV, V55, P355, DOI 10.2307/1129948
   GARDNER RA, 1969, SCIENCE, V165, P664, DOI 10.1126/science.165.3894.664
   Gardner B.T., 1989, P181
   GARDNER BT, 1994, NATO ADV SCI INST SE, V78, P223
   GARDNER BT, 1975, J EXP PSYCHOL GEN, V104, P244, DOI 10.1037//0096-3445.104.3.244
   FOUTS RS, 1994, NATO ADV SCI INST SE, V78, P257
   Gardner R.A., 1989, P1
   Gardner R A, 1978, Ann N Y Acad Sci, V309, P37, DOI 10.1111/j.1749-6632.1978.tb29441.x
   GARDNER RA, 1988, BEHAV BRAIN SCI, V11, P429
   Garvey C., 1975, CHILD LANGUAGE, V1, P41
   Goodall J, 1986, CHIMPANZEES GOMBE PA
   Hartmann JQ, 2011, INT J COMP PSYCHOL, V24, P177
   Jeanes R. C., 2000, J DEAF STUD DEAF EDU, V5, P237, DOI DOI 10.1093/DEAFED/5.3.237
   Jensvold M. L., 2002, J COMP PSYCHOL, V114, P335
   John AE, 2010, J SPEECH LANG HEAR R, V53, P950, DOI 10.1044/1092-4388(2009/08-0234)
   KEENAN EO, 1975, J PSYCHOLINGUIST RES, V4, P365, DOI 10.1007/BF01067065
   Keenan E. O., 1977, CHILD DISCOURSE, P125
   Krause MA, 1997, J COMP PSYCHOL, V111, P330, DOI 10.1037/0735-7036.111.4.330
   Kuczaj Stan A., 1982, LANGUAGE DEV LANGUAG, V2, P397
   Leitten L, 2012, INTERACT STUD, V13, P147, DOI 10.1075/is.13.2.01lei
   Lonborg S. D., 1991, J COUNS PSYCHOL, V34, P394
   Lyn H, 2011, LANG COMMUN, V31, P63, DOI 10.1016/j.langcom.2010.11.001
   MacRoy-Higgins M, 2012, COMM DISORD Q, V33, P242, DOI 10.1177/1525740112447942
   Miles L. W., 1976, ORIGINS EVOLUTION LA, V280, P592
   Morissette P., 1995, JOINT ATTENTION ITS, P85
   NICHOLAS JG, 2003, J DEAF STUDIES DEAF, V0008
   Nicholas JG, 1997, J SPEECH LANG HEAR R, V40, P1314
   Ninio A., 1994, J COMMUN DISORD, V27, P158
   PATTERSON F, 1988, J PRAGMATICS, V12, P35, DOI 10.1016/0378-2166(88)90018-5
   Rivas E, 2005, J COMP PSYCHOL, V119, P404, DOI 10.1037/0735-7036.119.4.404
   RUVOLO M, 1994, P NATL ACAD SCI USA, V91, P8900, DOI 10.1073/pnas.91.19.8900
   Searle J., 1969, SPEECH ACTS ESSAY PH
   SIBLEY CG, 1984, J MOL EVOL, V20, P2, DOI 10.1007/BF02101980
   Stamps J, 2003, ANIM BEHAV, V66, P1, DOI 10.1006/anbe.2003.2180
   STANYON R, 1986, AM J PHYS ANTHROPOL, V69, P489, DOI 10.1002/ajpa.1330690408
   Terrace H., 1979, NIM
   Terrace H. S., 1980, CHILDRENS LANGUAGE, V2, P371
   The Chimpanzee Sequencing and Analysis Consortium, 2005, SCIENCE, V437, P69, DOI [10.1038/nature04072, DOI 10.1038/NATURE04072]
   van Cantfort T.E., 1989, P198
   WEDELLMONNIG J, 1980, CHILD DEV, V51, P766, DOI 10.1111/j.1467-8624.1980.tb02612.x
   WETHERBY AM, 1988, J SPEECH HEAR RES, V31, P240
   WETHERBY AM, 1992, J SPEECH HEAR RES, V35, P130
   WETHERBY AM, 1984, J SPEECH HEAR RES, V27, P364
   WETHERBY AM, 1986, J AUTISM DEV DISORD, V16, P295, DOI 10.1007/BF01531661
   WETHERBY AM, 1989, J SPEECH HEAR DISORD, V54, P148
   Ziatas K, 2003, DEV PSYCHOPATHOL, V15, P73, DOI 10.1017/S0954579403000051
NR 77
TC 1
Z9 1
PU JOHN BENJAMINS PUBLISHING COMPANY
PI AMSTERDAM
PA PO BOX 36224, 1020 ME AMSTERDAM, NETHERLANDS
SN 0929-0907
EI 1569-9943
J9 PRAGMAT COGN
JI Pragmat. Cogn.
PY 2013
VL 21
IS 1
BP 224
EP 247
DI 10.1075/pc.21.1.10lee
PG 24
WC Linguistics; Language & Linguistics
SC Linguistics
GA 255YC
UT WOS:000327275000010
ER

PT J
AU Steinhausen, HC
AF Steinhausen, Hans-Christoph
TI What happens to children and adolescents with mental disorders? Findings
   from long-term outcome research
SO ZEITSCHRIFT FUR KINDER-UND JUGENDPSYCHIATRIE UND PSYCHOTHERAPIE
LA German
DT Review
DE mental disorders; childhood; adolescence; course; prognosis
ID DEFICIT-HYPERACTIVITY DISORDER; FOLLOW-UP; CONDUCT DISORDER;
   PSYCHIATRIC-PATIENTS; SPECTRUM DISORDERS; YOUNG ADULTHOOD; ELECTIVE
   MUTISM; EUROPE 2010; METAANALYSIS; CHILDHOOD
AB What happens to children and adolescents with mental disorders? Findings from long-term outcome research Research on the long-term outcome of mental disorders originating in childhood and adolescence is an important part of developmental psychopathology. After a brief sketch of relevant terms of outcome research, the first part of this review reports findings based on heterotypic cohort studies. The major second part of this review presents findings based on long-term outcome studies dealing with homotypic diagnostic groups. In particular, the review focuses on the course and prognosis of ADHD, anxiety disorders, depression, conduct disorders, eating disorders, autism spectrum disorders, schizophrenia, and selective mutism. Findings mainly support the vulnerability hypothesis regarding mental disorders with early manifestation in childhood and adolescence as frequent precursors of mental disorders in adulthood. The discussion focuses on the impact of early manifesting disorders in the frame of general mental morbidity and of the effect of interventions, which is not yet sufficiently discernible.
C1 Univ Krankenhaus Aalborg, Psychiat Krankenhaus Aalborg, Forschungseinheit Kinder & Jugendpsychiat, DK-9000 Aalborg, Denmark.
RP Steinhausen, HC (reprint author), Univ Krankenhaus Aalborg, Psychiat Krankenhaus Aalborg, Forschungseinheit Kinder & Jugendpsychiat, DK-9000 Aalborg, Denmark.
EM hces@rn.dk
CR Aebi M., EUROPEAN CH IN PRESS
   Andersen S. A., BMC PSYCHIA IN PRESS
   Antonovsky A., 1979, UNRAVELING MYTHERY H
   Beesdo-Baum K, 2012, ACTA PSYCHIAT SCAND, V126, P411, DOI 10.1111/j.1600-0447.2012.01886.x
   Brandeis D., 2010, BIOL PSYCHIAT, V67, P608
   Clemmensen L, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-150
   Dphnert M., 2013, J CHILD PSYCHOL PSYC, V54, P260
   Drechsler R, 2005, J CHILD PSYCHOL PSYC, V46, P824, DOI 10.1111/j.1469-7610.2004.00384.x
   Eschmann S, 2007, Z KL PSYCH PSYCHOTH, V36, P270, DOI 10.1026/1616-3443.36.4.270
   Faraone SV, 2006, PSYCHOL MED, V36, P159, DOI 10.1017/S003329170500471X
   Farrington D. P., 1999, RISKS OUTCOMES DEV P, P165
   Frick P., 1999, HDB DISRUPTIVE BEHAV
   Gustavsson A, 2011, EUR NEUROPSYCHOPHARM, V21, P718, DOI 10.1016/j.euroneuro.2011.08.008
   Hansson K, 2004, NORD J PSYCHIAT, V58, P5, DOI 10.1080/08039480310000734
   HARRINGTON R, 1990, ARCH GEN PSYCHIAT, V47, P465
   Harrison G, 2001, BRIT J PSYCHIAT, V178, P506, DOI 10.1192/bjp.178.6.506
   HEGARTY JD, 1994, AM J PSYCHIAT, V151, P1409
   Henninger NA, 2013, AUTISM, V17, P103, DOI 10.1177/1362361312441266
   Humphreys KL, 2013, JAMA PSYCHIAT, V70, P740, DOI 10.1001/jamapsychiatry.2013.1273
   Jaffee SR, 2002, ARCH GEN PSYCHIAT, V59, P215, DOI 10.1001/archpsyc.59.3.215
   Jobe TH, 2005, CAN J PSYCHIAT, V50, P892
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kossowsky J, 2013, AM J PSYCHIAT, V170, P768, DOI 10.1176/appi.ajp.2012.12070893
   LARSEN FW, 1990, ACTA PSYCHIAT SCAND, V81, P39, DOI 10.1111/j.1600-0447.1990.tb06446.x
   Lauritsen M. B., 2013, SYSTEMATIC QUA UNPUB
   Lichtenstein P, 2012, NEW ENGL J MED, V367, P2006, DOI 10.1056/NEJMoa1203241
   NYLANDER I, 1979, Acta Paediatrica Scandinavica Supplement, P1
   Olino TM, 2010, J ABNORM CHILD PSYCH, V38, P1139, DOI 10.1007/s10802-010-9427-9
   Olsson M, 2006, NORD J PSYCHIAT, V60, P469, DOI 10.1080/08039480601022041
   OSTMAN O, 1991, ACTA PSYCHIAT SCAND, V84, P40, DOI 10.1111/j.1600-0447.1991.tb01419.x
   OTTO G, 1978, ACTA PSYCHIAT SCAND, P5
   Remschmidt H, 2001, EUR ARCH PSY CLIN N, V251, P284, DOI 10.1007/PL00007547
   Robins L. N., 1966, DEVIANT CHILDREN GRO
   Sawyer AM, 2011, J CONSULT CLIN PSYCH, V79, P643, DOI 10.1037/a0024862
   Schweinhart L. J., 2005, LIFETIME EFFECTS HIG, V40
   Scott S., 2006, CLIN HDB CHILD ADOLE, P522
   Spohr HL, 2007, J PEDIATR-US, V150, P175, DOI 10.1016/j.jpeds.2006.11.044
   SPOHR HL, 1993, LANCET, V341, P907, DOI 10.1016/0140-6736(93)91207-3
   Steinhausen H. C., 2003, EUROPEAN CHILD AD S1, V12, P91
   Steinhausen HC, 2009, AM J PSYCHIAT, V166, P1331, DOI 10.1176/appi.ajp.2009.09040582
   Steinhausen HC, 2003, J AM ACAD CHILD PSY, V42, P1085, DOI 10.1097/01.CHI.0000070241.24125.A3
   Steinhausen HC, 2002, AM J PSYCHIAT, V159, P1284, DOI 10.1176/appi.ajp.159.8.1284
   Steinhausen HC, 2006, J AFFECT DISORDERS, V96, P49, DOI 10.1016/j.jad.2006.05.019
   Steinhausen H.-C., 2010, HDB ADHS GRUNDLAGEN, P152
   Steinhausen HC, 1998, PSYCHOL MED, V28, P375, DOI 10.1017/S0033291797005989
   Steinhausen HC, 1997, EUR CHILD ADOLES PSY, V6, P107
   STORMMATHISEN A, 1994, ACTA PSYCHIAT SCAND, V89, P416, DOI 10.1111/j.1600-0447.1994.tb01539.x
   Taylor Julie Lounds, 2012, COMP EFFECTIVENESS R, V65
   THOMSEN PH, 1990, ACTA PSYCHIAT SCAND, V81, P89, DOI 10.1111/j.1600-0447.1990.tb06456.x
   Weissman M., 1999, ARCH GEN PSYCHIAT, V56, P784
   Wittchen H. U., 1997, DIA X MANUAL INSTRUK
   Wittchen HU, 2011, EUR NEUROPSYCHOPHARM, V21, P655, DOI 10.1016/j.euroneuro.2011.07.018
NR 52
TC 2
Z9 2
PU VERLAG HANS HUBER
PI BERN 9
PA LANGGASS-STRASSE 76, CH-3000 BERN 9, SWITZERLAND
SN 1422-4917
EI 1664-2880
J9 Z KINDER JUG-PSYCH
JI Z. Kinder-und Jugendpsy. Psychother.
PY 2013
VL 41
IS 6
BP 419
EP 431
DI 10.1024/1422-4917/a000258
PG 13
WC Psychiatry
SC Psychiatry
GA 254RF
UT WOS:000327183600007
PM 24240498
ER

PT J
AU Taylor, B
   Jick, H
   MacLaughlin, D
AF Taylor, Brent
   Jick, Hershel
   MacLaughlin, Dean
TI Prevalence and incidence rates of autism in the UK: time trend from
   2004-2010 in children aged 8 years
SO BMJ OPEN
LA English
DT Article
ID PRACTICE RESEARCH DATABASE; UNITED-KINGDOM; RUBELLA VACCINATION;
   BREAST-CANCER; MUMPS; MEASLES; EPIDEMIOLOGY; POPULATION; DISORDERS;
   DIAGNOSIS
AB Objectives To update UK studies begun in the early 1990s on the annual prevalence and incidence rates of autism in children; undertaken in response to a March 2012 press release, widely covered by the media, from the US Centre for Disease Control (CDC) reporting that the autism prevalence rate in 2008 in 8-year-old US children was 1 in 88, a 78% increase from a CDC estimate in 2004. This finding suggested a continuation of the dramatic increase in children diagnosed as autistic, which occurred in the 1990s.
   Design Population study using the UK General Practice Research Database (GPRD).
   Methods Annual autism prevalence rates were estimated for children aged 8years in 2004-2010 by dividing the number diagnosed as autistic in each or any previous year by the number of children active in the study population that year. We also calculated annual incidence rates for children aged 2-8years, by dividing the number newly diagnosed in 2004-2010 by the same denominators.
   Results Annual prevalence rates for each year were steady at approximately 3.8/1000 boys and 0.8/1000 girls. Annual incidence rates each year were also steady at about 1.2/1000 boys and 0.2/1000 girls.
   Conclusions Following a fivefold increase in the annual incidence rates of autism during the 1990s in the UK, the incidence and prevalence rates in 8-year-old children reached a plateau in the early 2000s and remained steady through 2010. Whether prevalence rates have increased from the early 2000s in the USA remains uncertain.
C1 [Taylor, Brent] UCL Inst Child Hlth, Gen & Adolescent Paediat Unit, London, England.
   [Jick, Hershel; MacLaughlin, Dean] Boston Univ, Sch Med, Boston Collaborat Drug Surveillance Program, Lexington, MA 02215 USA.
RP Jick, H (reprint author), Boston Univ, Sch Med, Boston Collaborat Drug Surveillance Program, Lexington, MA 02215 USA.
EM hjick@bu.edu
CR Baird G, LANCET
   Black C, 2002, BRIT MED J, V325, P419, DOI 10.1136/bmj.325.7361.419
   Carey M., 2012, SUMMARY CDC AUTISM P, P1
   Charman T, 2009, INT J EPIDEMIOL, V38, P1234, DOI 10.1093/ije/dyp256
   Dales L, 2001, JAMA-J AM MED ASSOC, V285, P1183, DOI 10.1001/jama.285.9.1183
   Department of Developmental Services, 1999, CHANG POP PERS AUT P
   Department of Developmental Services, 2003, AUT SPECTR DIS CHANG
   DERBY LE, 1993, MED J AUSTRALIA, V158, P596
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Fisch GS, 2012, AM J MED GENET C, V160C, P91, DOI 10.1002/ajmg.c.31325
   Fombonne E, 2004, BMC PUBLIC HEALTH, V4, DOI 10.1186/1471-2458-4-5
   Hagberg KW, 2010, EPIDEMIOLOGY, V21, P426, DOI 10.1097/EDE.0b013e3181d61dd9
   Jick H, 2009, EPIDEMIOLOGY, V20, P656, DOI 10.1097/EDE.0b013e3181b056f5
   Jick H, 1992, PHARMACOEPIDEM DR S, V1, P347, DOI 10.1002/pds.2630010607
   Jick H, 2012, PHARMACOTHERAPY, V32, P970, DOI 10.1002/phar.1141
   JICK H, 1991, BRIT MED J, V302, P766
   Jick H, EPIDEMIOL RES INT, V2011, DOI [10.1155/2011/381597, DOI 10.1155/2011/381597]
   Jick H, 2004, BRIT J GEN PRACT, V54, P345
   Jick H, 2003, EPIDEMIOLOGY, V14, P630, DOI 10.1097/01.EDE.0000082044.88833.c4
   Jick SS, 2009, OBSTET GYNECOL, V113, P74, DOI 10.1097/AOG.0b013e31818fdde4
   Kaye JA, 2001, BRIT MED J, V322, P460, DOI 10.1136/bmj.322.7284.460
   Kaye JA, 2000, BRIT J CANCER, V83, P1556, DOI 10.1054/bjoc.2000.1493
   Keyes KM, 2012, INT J EPIDEMIOL, V41, P495, DOI 10.1093/ije/dyr193
   King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
   Lingam R, 2003, ARCH DIS CHILD, V88, P666, DOI 10.1136/adc.88.8.666
   Liu KY, 2010, AM J SOCIOL, V115, P1387
   Lord C, 2011, NATURE, V474, P166, DOI 10.1038/474166a
   Madsen KM, 2002, NEW ENGL J MED, V347, P1477, DOI 10.1056/NEJMoa021134
   Mazumdar S, 2010, HEALTH PLACE, V16, P539, DOI 10.1016/j.healthplace.2009.12.014
   Melero Montes MM, 2000, EPIDEMIOLOGY, V12, P123
   Smeeth L, 2004, LANCET, V364, P963, DOI 10.1016/S0140-6736(04)17020-7
   Taylor B, 2006, CHILD CARE HLTH DEV, V32, P511, DOI 10.1111/j.1365-2214.2006.00655.x
   Taylor B, 2002, BRIT MED J, V324, P393, DOI 10.1136/bmj.324.7334.393
   Taylor B, 1999, LANCET, V353, P2026, DOI 10.1016/S0140-6736(99)01239-8
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   Wakefield AJ, 1998, LANCET, V351, P637, DOI 10.1016/S0140-6736(97)11096-0
   Williams E, 2008, DEV MED CHILD NEUROL, V50, P672, DOI 10.1111/j.1469-8749.2008.03042.x
   Yergin-Allsop M, 2003, JAMA-J AM MED ASSOC, V289, P49
NR 38
TC 11
Z9 11
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2013
VL 3
IS 10
AR e003219
DI 10.1136/bmjopen-2013-003219
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 250UY
UT WOS:000326882800035
PM 24131525
ER

PT J
AU van Boxtel, JJA
   Lu, HJ
AF van Boxtel, Jeroen J. A.
   Lu, Hongjing
TI A biological motion toolbox for reading, displaying, and manipulating
   motion capture data in research settings
SO JOURNAL OF VISION
LA English
DT Article
DE biological motion; motion capture; toolbox
ID AUTISTIC SPECTRUM DISORDERS; POINT-LIGHT DISPLAYS; STIMULUS SET;
   PERCEPTION; RECOGNITION; CHILDREN; RESPONSES; LANGUAGE; EMOTION; INFANTS
AB Biological motion research is an increasingly active field, with a great potential to contribute to a wide range of applications, such as behavioral monitoring/motion detection in surveillance situations, intention inference in social interactions, and diagnostic tools in autism research. In recent years, a large amount of motion capture data has become freely available online, potentially providing rich stimulus sets for biological motion research. However, there currently does not exist an easy-to-use tool to extract, present and manipulate motion capture data in the MATLAB environment, which many researchers use to program their experiments. We have developed the Biomotion Toolbox, which allows researchers to import motion capture data in a variety of formats, to display actions using Psychtoolbox 3, and to manipulate action displays in specific ways (e. g., inversion, three-dimensional rotation, spatial scrambling, phase-scrambling, and limited lifetime). The toolbox was designed to allow researchers with a minimal level of MATLAB programming skills to code experiments using biological motion stimuli.
C1 [van Boxtel, Jeroen J. A.; Lu, Hongjing] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA.
   [van Boxtel, Jeroen J. A.] Monash Univ, Fac Med Nursing & Hlth Sci, Clayton, Vic 3800, Australia.
   [Lu, Hongjing] Univ Calif Los Angeles, Dept Stat, Los Angeles, CA USA.
RP van Boxtel, JJA (reprint author), Monash Univ, Sch Psychol & Psychiat, Clayton, Vic 3800, Australia.
EM j.j.a.vanboxtel@gmail.com
RI van Boxtel, Jeroen/O-7624-2014
OI van Boxtel, Jeroen/0000-0003-2643-0474
FU National Science Foundation [NSF BCS-0843880]; NSF [EIA-0196217]
FX This project was supported by a grant from the National Science
   Foundation (NSF BCS-0843880). The motion-capture data used in the sample
   code was obtained from http://mocap.cs.cmu.edu, which was created with
   funding from NSF EIA-0196217.
CR Beintema JA, 2002, P NATL ACAD SCI USA, V99, P5661, DOI 10.1073/pnas.082483699
   BERTENTHAL BI, 1987, J EXP PSYCHOL HUMAN, V13, P577, DOI 10.1037/0096-1523.13.4.577
   Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434
   Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357
   Carter EJ, 2006, SOC NEUROSCI, V1, P396, DOI 10.1080/17470910601041382
   Chang DHF, 2009, J VISION, V9, DOI 10.1167/9.1.19
   Chouchourelou A, 2006, SOC NEUROSCI, V1, P63, DOI 10.1080/17470910600630599
   DITTRICH WH, 1993, PERCEPTION, V22, P15, DOI 10.1068/p220015
   Dittrich WH, 1996, PERCEPTION, V25, P727, DOI 10.1068/p250727
   FOX R, 1982, SCIENCE, V218, P486, DOI 10.1126/science.7123249
   Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025
   Grossman E, 2000, J COGNITIVE NEUROSCI, V12, P711, DOI 10.1162/089892900562417
   Guerra-Filho G, 2012, IMAGE VISION COMPUT, V30, P251, DOI 10.1016/j.imavis.2011.12.002
   HERMAN LM, 1990, J EXP PSYCHOL GEN, V119, P215, DOI 10.1037//0096-3445.119.2.215
   Herrington JD, 2007, RES AUTISM SPECT DIS, V1, P14, DOI 10.1016/j.rasd.2006.07.002
   Hirai M, 2008, J VISION, V8, DOI 10.1167/8.16.2
   Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y
   Iacoboni M, 2004, NEUROIMAGE, V21, P1167, DOI 10.1016/j.neuroimage.2003.11.013
   JOHANSSO.G, 1973, PERCEPT PSYCHOPHYS, V14, P201, DOI 10.3758/BF03212378
   Kaiser MD, 2012, DEV COGN NEUROS-NETH, V2, P25, DOI 10.1016/j.dcn.2011.05.005
   Ma YL, 2006, BEHAV RES METHODS, V38, P134, DOI 10.3758/BF03192758
   Manera V, 2010, BEHAV RES METHODS, V42, P168, DOI 10.3758/BRM.42.1.168
   Matsuzaki N, 2008, PERCEPTION, V37, P1560, DOI 10.1068/p5769
   Muller M., 2007, CG20072 U BONN
   Murphy P, 2009, NEUROPSYCHOLOGIA, V47, P3225, DOI 10.1016/j.neuropsychologia.2009.07.026
   Norman JF, 2004, PSYCHOL AGING, V19, P219, DOI 10.1037/0882-7974.19.1.219
   ORAM MW, 1994, J COGNITIVE NEUROSCI, V6, P99, DOI 10.1162/jocn.1994.6.2.99
   Parron C, 2008, AUTISM, V12, P261, DOI 10.1177/1362361307089520
   Pavlova M, 2000, PERCEPT PSYCHOPHYS, V62, P889, DOI 10.3758/BF03212075
   Pelli DG, 1997, SPATIAL VISION, V10, P437, DOI 10.1163/156856897X00366
   Pelphrey KA, 2008, ANN NY ACAD SCI, V1145, P283, DOI 10.1196/annals.1416.007
   Pilz KS, 2010, VISION RES, V50, P211, DOI 10.1016/j.visres.2009.11.014
   POIZNER H, 1981, J EXP PSYCHOL HUMAN, V7, P430, DOI 10.1037//0096-1523.7.2.430
   Pollick FE, 2001, COGNITION, V82, pB51, DOI 10.1016/S0010-0277(01)00147-0
   Pollick FE, 2003, PERCEPTION, V32, P813, DOI 10.1068/p3319
   Regolin L., 2000, ANIMAL COGNITION, V3, P53, DOI 10.1007/s100710050050
   Roether C., 2009, J VISION, V8, P1, DOI DOI 10.1167/9.6.15
   SUMI S, 1984, PERCEPTION, V13, P283, DOI 10.1068/p130283
   Thurman S. M., 2013, J VISION, V13, P1, DOI [10.1167/13.2.8., DOI 10.1167/13.2.8.[]
   van Boxtel JJA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037085
   van Boxtel JJA, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00209
   van Boxtel J. J., 2011, J VISION, V11, P1, DOI [10.1167/11.7.19., DOI 10.1167/11.7.19.[]
   Vangeneugden J, 2009, CEREB CORTEX, V19, P593, DOI 10.1093/cercor/bhn109
   Vanrie J, 2004, BEHAV RES METH INS C, V36, P625, DOI 10.3758/BF03206542
NR 44
TC 3
Z9 3
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 1534-7362
J9 J VISION
JI J. Vision
PY 2013
VL 13
IS 12
AR 7
DI 10.1167/13.12.7
PG 16
WC Ophthalmology
SC Ophthalmology
GA 247LS
UT WOS:000326619500007
ER

PT J
AU Kocourkova, J
   Dudova, I
   Koutek, J
AF Kocourkova, Jana
   Dudova, Iva
   Koutek, Jiri
TI Asperger syndrome related suicidal behavior: two case studies
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE Asperger syndrome; suicidal behavior; adolescence
ID AUTISM SPECTRUM DISORDERS; DIAGNOSIS; CHILDREN
AB Asperger syndrome hinders adaptation to developmental challenges during childhood and adolescence, particularly with regard to interpersonal relationships. Individuals with Asperger syndrome display lack of empathy and limited ability to understand social and emotional exchanges with other people. Individuals with Asperger syndrome are significantly exposed to the risk of suicidal behavior, especially during adolescence. The authors describe cases of suicidal behavior in two adolescent boys with Asperger syndrome.
C1 [Kocourkova, Jana; Dudova, Iva; Koutek, Jiri] Charles Univ Prague, Fac Med 2, Univ Hosp Motol, Dept Child Psychiat, Prague 15006, Czech Republic.
RP Kocourkova, J (reprint author), Charles Univ Prague, Fac Med 2, Univ Hosp Motol, Dept Child Psychiat, V Uvalu 84, Prague 15006, Czech Republic.
EM jana.kocourkova@lfmotol.cuni.cz
FU Ministry of Health, Czech Republic
FX This paper was written within the Programme for the Development of
   Fields of Study at Charles University (P07 Psychosocial Aspects of the
   Quality of Human Life), supported by the Ministry of Health, Czech
   Republic. Conceptual development of research: University Hospital Motol,
   Prague, Czech Republic 00064203.
CR Deprey L, 2009, ASSESSMENT AUTISM SP
   Fitzgerald M, 2007, CRISIS, V28, P1, DOI 10.1027/0227-5910.28.1.1
   Gothelf D, 1998, J AM ACAD CHILD PSY, V37, P1279, DOI 10.1097/00004583-199812000-00011
   HRDLICKA M., 2004, DETSKY AUTISMUS
   Kaplan H. I., 1998, SYNOPSIS PSYCHIAT
   Kato K, 2013, GEN HOSP PSYCHIAT, V35, P50, DOI 10.1016/j.genhosppsych.2012.09.006
   Kenny C, 2001, SUICIDAL CHILDREN AD
   King R. A., 2003, SUICIDE CHILDREN ADO
   Lainhart JE, 1999, INT REV PSYCHIATR, V11, P278, DOI 10.1080/09540269974177
   Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
   McConachie H, 2005, J AUTISM DEV DISORD, V35, P167, DOI 10.1007/s10803-005-1995-0
   Miller JN, 2011, TXB AUTISM SPECTRUM
   Raja Michele, 2011, Clin Pract Epidemiol Ment Health, V7, P97, DOI 10.2174/1745017901107010097
   Shtayermman Oren, 2007, Issues Compr Pediatr Nurs, V30, P87, DOI 10.1080/01460860701525089
   Shtayermman O., 2008, J HUMAN BEHAV SOCIAL, V18, P301, DOI 10.1080/10911350802427548
   Spencer L, 2011, AM J PSYCHIAT, V168, P890, DOI 10.1176/appi.ajp.2011.10091261
   THOROVA K., 2006, PORUCHY AUTISTICKEHO
   Woodbury-Smith MR, 2009, EUR CHILD ADOLES PSY, V18, P2, DOI 10.1007/s00787-008-0701-0
NR 18
TC 0
Z9 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1176-6328
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2013
VL 9
BP 1815
EP 1819
DI 10.2147/NDT.549289
PG 5
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 254SW
UT WOS:000327188300001
PM 24294002
ER

PT J
AU Frei, A
AF Frei, Andreas
TI Attempted homicide as a consequence of misunderstood familial solidarity
   in a case of "Asperger-Syndrome" A case report
SO RECHT & PSYCHIATRIE
LA German
DT Article
DE Autistic spectrum disorder; pervasive developmental disorder; Asperger
   syndrome; Theory of Mind; homicide
ID MIND; DISORDERS; PSYCHOPATHY; AUTISM; CHILD
AB Mr. M was a young man of 18 years who had achieved little in his private as well as his professional life. He was assessed by a forensic psychiatrist after he had tried to kill a younger girl from the neighbourhood whom he suspected to intrude in and hence disturb his intact family-life. He was diagnosed to suffer from mixed personality disorder with schizoid and avoidant traits, and in-patient treatment in a forensic psychiatric hospital instead of prison was recommended. On the occasion of a new assessment concerning medico-legal prognosis the diagnosis was changed to pervasive developmental disorder, Asperger syndrome. Violent offences perpetrated by patients suffering from pervasive developmental or autistic spectrum disorder are often characterized by a wish for social contact associated with social naivete which may cause frustration and aggression. This lack of social skills is referred to as a Theory of Mind deficit.
C1 Luzerner Psychiat, Forens Dienst, CH-6005 Luzern, Switzerland.
RP Frei, A (reprint author), Luzerner Psychiat, Forens Dienst, Voltastr 42, CH-6005 Luzern, Switzerland.
CR Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
   Baron-Cohen S, 2005, J AUTISM DEV DISORD, V35, P807, DOI 10.1007/s10803-005-0026-5
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Berney T, 2004, ADV PSYCHIAT TREATME, P341, DOI DOI 10.1192/APT.10.5.341
   Dolan M, 2004, PSYCHOL MED, V34, P1093, DOI 10.1017/S0033291704002028
   Dose M, 2010, FORTSCHR NEUROL PSYC, V78, P233, DOI 10.1055/s-0028-1109588
   ERMER A, 2001, RECHT PSYCHIATR, V19, P73
   Forstl H, 2007, THEORY MIND NEUROBIO
   GHAZIUDDIN M, 2011, J AUTISM DEV DISORD, V40, P1146
   Gillberg C, 1998, BRIT J PSYCHIAT, V172, P200, DOI 10.1192/bjp.172.3.200
   GONZALES CABEZA S, 1998, D35114 I FOR PSYCH H
   HALFON N, 2013, J AM MED ASS PAEDIAT, V3, P1, DOI [10.1001/jamapediatrics.2013.2188, DOI 10.1001/JAMAPEDIATRICS.2013.2188]
   Hare R. D., 2003, MANUAL REVISED PSYCH
   Hart S. D., 1995, HARE PSYCHOPATHY CHE
   Kaland N, 2011, RES AUTISM SPECT DIS, V5, P984, DOI 10.1016/j.rasd.2011.01.011
   Krippl M, 2011, NERVENARZT, V82, P843, DOI 10.1007/s00115-010-3073-x
   KROBER HL, 2010, HDB FORENSISCH PSYCH, V2, P158
   Kumbier E, 2010, NERVENARZT, V81, P55, DOI 10.1007/s00115-009-2820-3
   MURRIE D. C., 2002, INT J FORENSIC MENTA, V1, P59, DOI DOI 10.1080/14999013.2002.10471161
   PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515
   SASS H, 1983, NERVENARZT, V54, P557
   SCRAGG P, 1994, BRIT J PSYCHIAT, V165, P679, DOI 10.1192/bjp.165.5.679
   Silva JA, 2002, J FORENSIC SCI, V47, P1347
   Siponmaa L, 2001, J AM ACAD PSYCHIATRY, V29, P420
   SOKOL DK, 2004, J NEUROIMAGING, V14, P8, DOI DOI 10.1177/1051228403258145
   Steinbock H, 2008, RECHT PSYCHIATR, V26, P135
   TANTAM D, 1988, BRIT J PSYCHIAT, V153, P777, DOI 10.1192/bjp.153.6.777
   VITT-MUGG V, 2003, SEXUELL SADISTISCHE
   Vollm BA, 2006, NEUROIMAGE, V29, P90, DOI 10.1016/j.neuroimage.2005.07.022
   WING L, 1981, PSYCHOL MED, V11, P115
NR 30
TC 0
Z9 0
PU PSYCHIATRIE VERLAG GMBH
PI BONN
PA THOMAS-MANN-STRASSE 49A, BONN, 53111, GERMANY
SN 0724-2247
J9 RECHT PSYCHIATR
JI Recht Psychiatr.
PY 2013
VL 31
IS 4
BP 202
EP 207
PG 6
WC Criminology & Penology; Psychiatry
SC Criminology & Penology; Psychiatry
GA 253AK
UT WOS:000327053800004
ER

PT J
AU Wang, M
   Reid, D
AF Wang, Michelle
   Reid, Denise
TI Using the Virtual Reality-Cognitive Rehabilitation Approach to Improve
   Contextual Processing in Children with Autism
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID SINGLE-SUBJECT RESEARCH; HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS;
   ASPERGER-SYNDROME; CENTRAL COHERENCE; FLEXIBILITY; ADOLESCENTS;
   ENVIRONMENTS; OBJECTS; ADULTS
AB Background. This pilot study investigated the efficacy of a novel virtual reality-cognitive rehabilitation (VR-CR) intervention to improve contextual processing of objects in children with autism. Previous research supports that children with autism show deficits in contextual processing, as well as deficits in its elementary components: abstraction and cognitive flexibility. Methods. Four children with autism participated in a multiple-baseline, single-subject study. The children were taught how to see objects in context by reinforcing attention to pivotal contextual information. Results. All children demonstrated statistically significant improvements in contextual processing and cognitive flexibility. Mixed results were found on the control test and changes in context-related behaviours. Conclusions. Larger-scale studies are warranted to determine the effectiveness and usability in comprehensive educational programs.
C1 [Wang, Michelle] Queens Univ, Off Undergrad Med Educ, Kingston, ON K7L 3N6, Canada.
   [Reid, Denise] Univ Toronto, Virtual Real & Neurorehabil Lab, Toronto, ON M5G 1V7, Canada.
RP Wang, M (reprint author), Queens Univ, Off Undergrad Med Educ, 80 Barrie St, Kingston, ON K7L 3N6, Canada.
EM mwang@qmed.ca
FU Canadian Institutes in Health Research; William Courtney Clayton
   Paediatric Research Award; Ontario Council of Graduate Studies Autism
   Scholar's Award
FX This study has been supported by the following Grants awarded to the
   first author: Canadian Institutes in Health Research 2008-09 Master's
   Award, Hilda and William Courtney Clayton Paediatric Research Award
   2008-09, and Ontario Council of Graduate Studies Autism Scholar's Award
   2009-10. This paper was prepared from a Masters thesis by the first
   author. The authors give thanks to Bloorview Kids Rehab, Autism Ontario
   and the Geneva Centre for help with recruitment. Special thanks to Fan
   (Mimi) Zhang for technical support, and Luigi Girolametto and Tom Chau
   for their mentorship and valuable feedback throughout the project.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Bar M, 2004, NAT REV NEUROSCI, V5, P617, DOI 10.1038/nrn1476
   Berg EA, 1948, J GEN PSYCHOL, V39, P15
   Berger HJC, 2003, J CLIN EXP NEUROPSYC, V25, P502, DOI 10.1076/jcen.25.4.502.13870
   BERGER HJC, 1993, J AUTISM DEV DISORD, V23, P341, DOI 10.1007/BF01046224
   Blaye A, 2001, BRIT J DEV PSYCHOL, V19, P395, DOI 10.1348/026151001166173
   Burdea G. C., 2003, VIRTUAL REALITY TECH
   Butler RW, 2007, PEDIATRIC NEUROPSYCHOLOGICAL INTERVENTION: A CRITICAL REVIEW OF SCIENCE AND PRACTICE, P444
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   GRANT DA, 1948, J EXP PSYCHOL, V38, P404, DOI 10.1037/h0059831
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Jacques S., 2001, ROLES LABELLING ABST
   Jolliffe T, 2001, VIS COGN, V8, P67
   Kaland N, 2008, J AUTISM DEV DISORD, V38, P1161, DOI 10.1007/s10803-007-0474-1
   Klinger LG, 2001, DEV PSYCHOPATHOL, V13, P111, DOI 10.1017/S0954579401001080
   Logan LR, 2008, DEV MED CHILD NEUROL, V50, P99, DOI 10.1111/j.1469-8749.2007.02005.x
   Lopez BR, 2005, J AUTISM DEV DISORD, V35, P445, DOI 10.1007/s10803-005-5035-x
   Minshew NJ, 2002, NEUROPSYCHOLOGY, V16, P327, DOI 10.1037//0894-4105.16.3.327
   Mitchell P, 2007, J AUTISM DEV DISORD, V37, P589, DOI 10.1007/s10803-006-0189-8
   Ozonoff S., 1991, SPECIFYING NATURE PR
   PRIOR M, 1990, J AUTISM DEV DISORD, V20, P581, DOI 10.1007/BF02216063
   Rice Catherine, 2009, Morbidity and Mortality Weekly Report, V58, P1
   Rizzo AA, 1997, ST HEAL T, V44, P123
   Rizzo AA, 2004, NEUROPSYCHOL REHABIL, V14, P207, DOI 10.1080/09602010343000183
   Roid G., 1997, LEITER INT PERFORMAN
   Ropar D, 2007, J AUTISM DEV DISORD, V37, P270, DOI 10.1007/s10803-006-0166-2
   Rose FD, 2000, ERGONOMICS, V43, P494, DOI 10.1080/001401300184378
   Schopler E., 1988, CHILDHOOD AUTISM RAT
   Scruggs TE, 1998, BEHAV MODIF, V22, P221, DOI 10.1177/01454455980223001
   Self T, 2007, TOP LANG DISORD, V27, P242
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Strickland D, 1996, J AUTISM DEV DISORD, V26, P651, DOI 10.1007/BF02172354
   Wang M., 2009, J CYBER THERAPY REHA, V2, P95
   Witmer BG, 2005, PRESENCE-TELEOP VIRT, V14, P298, DOI 10.1162/105474605323384654
NR 34
TC 0
Z9 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 716890
DI 10.1155/2013/716890
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 256SN
UT WOS:000327334300001
ER

PT J
AU Huguet, G
   Ey, E
   Bourgeron, T
AF Huguet, Guillaume
   Ey, Elodie
   Bourgeron, Thomas
BE Chakravarti, A
   Green, E
TI The Genetic Landscapes of Autism Spectrum Disorders
SO ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 14
SE Annual Review of Genomics and Human Genetics
LA English
DT Review; Book Chapter
DE copy-number variant; synapse; de novo mutation; animal models
ID DE-NOVO MUTATIONS; COPY NUMBER VARIATION; PRADER-WILLI-SYNDROME;
   IDIOPATHIC GENERALIZED EPILEPSY; SCAFFOLDING PROTEIN SHANK3;
   FRAGILE-X-SYNDROME; MENTAL-RETARDATION; ANGELMAN SYNDROME; MICRODELETION
   SYNDROME; RETT-SYNDROME
AB The autism spectrum disorders (ASD) are characterized by impairments in social interaction and stereotyped behaviors. For the majority of individuals with ASD, the causes of the disorder remain unknown; however, in up to 25% of cases, a genetic cause can be identified. Chromosomal rearrangements as well as rare and de novo copy-number variants are present in similar to 10-20% of individuals with ASD, compared with 1-2% in the general population and/or unaffected siblings. Rare and de novo coding-sequence mutations affecting neuronal genes have also been identified in similar to 5-10% of individuals with ASD. Common variants such as single-nucleotide polymorphisms seem to contribute to ASD susceptibility, but, taken individually, their effects appear to be small. Despite a heterogeneous genetic landscape, the genes implicated thus far-which are involved in chromatin remodeling, metabolism, mRNA translation, and synaptic function-seem to converge in common pathways affecting neuronal and synaptic homeostasis. Animal models developed to study these genes should lead to a better understanding of the diversity of the genetic landscapes of ASD.
C1 [Huguet, Guillaume; Ey, Elodie; Bourgeron, Thomas] Inst Pasteur, Human Genet & Cognit Funct Unit, F-75015 Paris, France.
   [Huguet, Guillaume; Ey, Elodie; Bourgeron, Thomas] Inst Pasteur, CNRS, URA Genes Synapses & Cognit 2182, F-75015 Paris, France.
   [Huguet, Guillaume; Ey, Elodie; Bourgeron, Thomas] Univ Paris Diderot, Sorbonne Paris Cite, Human Genet & Cognit Funct Unit, F-75013 Paris, France.
RP Huguet, G (reprint author), Inst Pasteur, Human Genet & Cognit Funct Unit, F-75015 Paris, France.
EM thomasb@pasteur.fr
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Alkan C, 2011, NAT REV GENET, V12, P363, DOI 10.1038/nrg2958
   Amir RE, 1999, NAT GENET, V23, P185
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
   Arons MH, 2012, J NEUROSCI, V32, P14966, DOI 10.1523/JNEUROSCI.2215-12.2012
   Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
   Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
   Ballif BC, 2007, NAT GENET, V39, P1071, DOI 10.1038/ng2107
   Battaglia A, 2009, AM J MED GENET A, V149A, P1200, DOI 10.1002/ajmg.a.32847
   Baudouin SJ, 2012, SCIENCE, V338, P128, DOI 10.1126/science.1224159
   Ben-Shachar S, 2009, J MED GENET, V46, P382, DOI 10.1136/jmg.2008.064378
   Berkel S, 2011, HUM MOL GENET, V21, P344
   Bijlsma EK, 2009, EUR J MED GENET, V52, P77, DOI 10.1016/j.ejmg.2009.03.006
   Bittel DC, 2006, PEDIATRICS, V118, pE1276, DOI 10.1542/peds.2006.0424
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   Burnside R, 2011, HUM GENET, V130, P517, DOI 10.1007/s00439-011-0970-4
   Butler MG, 2008, AM J MED GENET A, V146A, P854, DOI 10.1002/ajmg.a.32249
   Camacho-Garcia RJ, 2012, NEUROBIOL DIS, V47, P135, DOI 10.1016/j.nbd.2012.03.031
   Casey JP, 2011, HUM GENET, V131, P565
   Celestino-Soper PBS, 2012, P NATL ACAD SCI USA, V109, P7974, DOI 10.1073/pnas.1120210109
   Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22
   Chih B, 2004, HUM MOL GENET, V13, P1471, DOI 10.1093/hmg/ddh158
   Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009
   Coleman M., 2012, AUTISMS
   BAKKER CE, 1994, CELL, V78, P23
   Cook EH, 1997, AM J HUM GENET, V60, P928
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   Davies G, 2011, MOL PSYCHIATR, V16, P996, DOI 10.1038/mp.2011.85
   Depienne C, 2007, J MED GENET, V44, P452, DOI 10.1136/jmg.2006.047092
   Depienne C, 2009, BIOL PSYCHIAT, V66, P349, DOI 10.1016/j.biopsych.2009.01.025
   Derecki NC, 2012, NATURE, V484, P105, DOI 10.1038/nature10907
   Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002
   Dibbens LM, 2009, HUM MOL GENET, V18, P3626, DOI 10.1093/hmg/ddp311
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Durand CM, 2011, MOL PSYCHIATR, V17, P71
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Ey E, 2012, GENES BRAIN BEHAV, V11, P928, DOI 10.1111/j.1601-183X.2012.00849.x
   Ey E, 2010, AUTISM RES, V4, P5
   Fernandez BA, 2010, J MED GENET, V47, P195, DOI 10.1136/jmg.2009.069369
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896
   Gauthier J, 2010, P NATL ACAD SCI USA, V107, P7863, DOI 10.1073/pnas.0906232107
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Golzio C, 2012, NATURE, V485, P363, DOI 10.1038/nature11091
   Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hartley SL, 2005, AM J MED GENET A, V136A, P140, DOI 10.1002/ajmg.a.30771
   Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Stone JL, 2008, NATURE, V455, P237, DOI 10.1038/nature07239
   Itsara A, 2010, GENOME RES, V20, P1469, DOI 10.1101/gr.107680.110
   Jacquemont ML, 2006, J MED GENET, V43, P843, DOI 10.1136/jmg.2006.043166
   Jacquemont S, 2011, NATURE, V478, P97, DOI 10.1038/nature10406
   Jacquemont S, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001708
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Kanner L, 1943, NERV CHILD, V2, P217
   Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017
   Kirov G, 2008, HUM MOL GENET, V17, P458, DOI 10.1093/hmg/ddm323
   Kishino T, 1997, NAT GENET, V15, P70, DOI 10.1038/ng0197-70
   Klei L, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-9
   Kong A, 2012, NATURE, V488, P471, DOI 10.1038/nature11396
   Konyukh M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017289
   Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376
   Kumar RA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004582
   Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
   LeBlanc JJ, 2011, NEURAL PLAST, DOI 10.1155/2011/921680
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
   Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
   Mabb AM, 2011, TRENDS NEUROSCI, V34, P293, DOI 10.1016/j.tins.2011.04.001
   Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   Matsuura T, 1997, NAT GENET, V15, P74, DOI 10.1038/ng0197-74
   Miller DT, 2009, J MED GENET, V46, P242, DOI 10.1136/jmg.2008.059907
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   Napoli I, 2008, CELL, V134, P1042, DOI 10.1016/j.cell.2008.07.031
   Nava C, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.102
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Neves-Pereira M, 2009, J MED GENET, V46, P759, DOI 10.1136/jmg.2009.066852
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Pagnamenta AT, 2009, EUR J HUM GENET, V17, P687, DOI 10.1038/ejhg.2008.228
   Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   PIERETTI M, 1991, CELL, V66, P817, DOI 10.1016/0092-8674(91)90125-I
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Ramocki MB, 2008, NATURE, V455, P912, DOI 10.1038/nature07457
   Rujescu D, 2009, HUM MOL GENET, V18, P988, DOI 10.1093/hmg/ddn351
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
   Schenck A, 2003, NEURON, V38, P887, DOI 10.1016/S0896-6273(03)00354-4
   Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Sharp AJ, 2008, NAT GENET, V40, P322, DOI 10.1038/ng.93
   Shinawi M, 2009, NAT GENET, V41, P1269, DOI 10.1038/ng.481
   Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851
   Skafidas E, 2014, MOL PSYCHIATR, V19, P504, DOI 10.1038/mp.2012.126
   Somerville MJ, 2005, NEW ENGL J MED, V353, P1694, DOI 10.1056/NEJMoa051962
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Sutcliffe JS, 1997, GENOME RES, V7, P368
   Szafranski P, 2010, HUM MUTAT, V31, P840, DOI 10.1002/humu.21284
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221
   Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007
   van Bon BWM, 2009, J MED GENET, V46, P511, DOI 10.1136/jmg.2008.063412
   Van der Aa N, 2009, EUR J MED GENET, V52, P94, DOI 10.1016/j.ejmg.2009.02.006
   van der Zwaag B, 2010, AM J MED GENET B, V153B, P960, DOI 10.1002/ajmg.b.31055
   Veltman MWM, 2005, PSYCHIAT GENET, V15, P243, DOI 10.1097/00041444-200512000-00006
   Verhoeven WMA, 2012, NEUROPSYCH DIS TREAT, V8, P175, DOI 10.2147/NDT.S30506
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Vorstman JA, 2010, MOL PSYCHIATR, V16, P442
   Vorstman JAS, 2006, MOL PSYCHIATR, V11, P18, DOI 10.1038/sj.mp.4001757
   Vucurovic K, 2012, EUR J MED GENET, V55, P625, DOI 10.1016/j.ejmg.2012.07.009
   Waddington CH, 1942, NATURE, V150, P563, DOI 10.1038/150563a0
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
   Woltereck R, 1909, VERH DTSCH ZOOL GES, V19, P110
   Won H, 2012, NATURE, V486, P261, DOI 10.1038/nature11208
   Yamasaki K., 2003, Human Molecular Genetics, V12, P837, DOI 10.1093/hmg/ddg106
   Yang JA, 2010, NAT GENET, V42, P565, DOI 10.1038/ng.608
   Yaspan BL, 2011, HUM GENET, V129, P563, DOI 10.1007/s00439-011-0956-2
   Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
   Zweier C, 2009, AM J HUM GENET, V85, P655, DOI 10.1016/j.ajhg.2009.10.004
NR 134
TC 40
Z9 42
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 1527-8204
BN 978-0-8243-3714-8
J9 ANNU REV GENOM HUM G
JI Annu. Rev. Genomics Hum. Genet.
PY 2013
VL 14
BP 191
EP 213
DI 10.1146/annurev-genom-091212-153431
PG 23
WC Genetics & Heredity
SC Genetics & Heredity
GA BHU05
UT WOS:000326658500009
PM 23875794
ER

PT J
AU Yi, L
   Fan, YB
   Quinn, PC
   Feng, C
   Huang, D
   Li, J
   Mao, GQ
   Lee, K
AF Yi, Li
   Fan, Yuebo
   Quinn, Paul C.
   Feng, Cong
   Huang, Dan
   Li, Jiao
   Mao, Guoquan
   Lee, Kang
TI Abnormality in face scanning by children with autism spectrum disorder
   is limited to the eye region: Evidence from multi-method analyses of eye
   tracking data
SO JOURNAL OF VISION
LA English
DT Article
DE autism spectrum disorder; face processing; face recognition; eye
   movements; eye tracking
ID DIAGNOSTIC INTERVIEW; FACIAL EXPRESSIONS; NEURAL CIRCUITRY;
   YOUNG-CHILDREN; RECOGNITION; INDIVIDUALS; FIXATION; LOOKING; IMPAIRMENT;
   MOVEMENTS
AB There has been considerable controversy regarding whether children with autism spectrum disorder (ASD) and typically developing children (TD) show different eye movement patterns when processing faces. We investigated ASD and age-and IQ-matched TD children's scanning of faces using a novel multi-method approach. We found that ASD children spent less time looking at the whole face generally. After controlling for this difference, ASD children's fixations of the other face parts, except for the eye region, and their scanning paths between face parts were comparable either to the age-matched or IQ-matched TD groups. In contrast, in the eye region, ASD children's scanning differed significantly from that of both TD groups: (a) ASD children fixated significantly less on the right eye (from the observer's view); (b) ASD children's fixations were more biased towards the left eye region; and (c) ASD children fixated below the left eye, whereas TD children fixated on the pupil region of the eye. Thus, ASD children do not have a general abnormality in face scanning. Rather, their abnormality is limited to the eye region, likely due to their strong tendency to avoid eye contact.
C1 [Yi, Li; Li, Jiao; Mao, Guoquan] Sun Yat Sen Univ, Dept Psychol, Guangzhou 510275, Guangdong, Peoples R China.
   [Fan, Yuebo] Guangzhou Cana Sch, Guangzhou, Guangdong, Peoples R China.
   [Fan, Yuebo; Huang, Dan] Guangzhou Rehabil & Res Ctr Children ASD, Guangzhou, Guangdong, Peoples R China.
   [Quinn, Paul C.] Univ Delaware, Dept Psychol, Newark, DE USA.
   [Feng, Cong] Sun Yat Sen Univ, Dept Philosophy, Guangzhou 510275, Guangdong, Peoples R China.
   [Feng, Cong] Sun Yat Sen Univ, Inst Log & Cognit, Guangzhou 510275, Guangdong, Peoples R China.
   [Lee, Kang] Univ Toronto, Dr Eric Jackman Inst Child Study, Toronto, ON, Canada.
RP Lee, K (reprint author), Univ Toronto, Dr Eric Jackman Inst Child Study, Toronto, ON, Canada.
EM yili5@mail.sysu.edu.cn; kang.lee@utoronto.ca
FU Humanity and Social Science Youth Foundation of the Ministry of
   Education of China [12YJC190034]; Foundation for Distinguished Young
   Talents in Higher Education of Guangdong, China [WYM10117]; National
   Natural Science Foundation of China [31200779]; Fundamental Research
   Funds for the Central Universities [13wkpy40]; Scientific Research
   Foundation for the Returned Overseas Chinese Scholar of the Ministry of
   Education of China; National Institutes of Health [R01HD046526,
   R01HD060595]; Natural Sciences and Engineering Research Council of
   Canada (NSERC)
FX This work was supported by grants from the Humanity and Social Science
   Youth Foundation of the Ministry of Education of China (12YJC190034),
   the Foundation for Distinguished Young Talents in Higher Education of
   Guangdong, China (WYM10117), the National Natural Science Foundation of
   China (31200779), the Fundamental Research Funds for the Central
   Universities (13wkpy40), the Scientific Research Foundation for the
   Returned Overseas Chinese Scholar of the Ministry of Education of China,
   and grants from National Institutes of Health (R01HD046526 and
   R01HD060595) and Natural Sciences and Engineering Research Council of
   Canada (NSERC). The authors are grateful to Shanghai Psytech Electronic
   Technology Co. Ltd., Chigangyuan Kindergarten, Yongxing Primary School,
   Xiaofeng Jie, Xianmai Wang, Tanzhi Hou, Jiao Li, Yunyi Li, Hui Wang, and
   Naiqi Xiao, for their generous assistance in completing the studies.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
   BAHILL AT, 1981, INVEST OPHTH VIS SCI, V21, P116
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Bar-Haim Y, 2006, J AUTISM DEV DISORD, V36, P131, DOI 10.1007/s10803-005-0046-1
   Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
   Caldara R, 2011, BEHAV RES METHODS, V43, P864, DOI 10.3758/s13428-011-0092-x
   Chauvin A, 2005, J VISION, V5, P659, DOI 10.1167/5.9.1
   Chawarska K, 2010, ARCH GEN PSYCHIAT, V67, P178, DOI 10.1001/archgenpsychiatry.2009.194
   Chawarska K, 2009, J AUTISM DEV DISORD, V39, P1663, DOI 10.1007/s10803-009-0803-7
   Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
   de Wit TCJ, 2008, RES AUTISM SPECT DIS, V2, P651, DOI 10.1016/j.rasd.2008.01.004
   FALCKYTTER T, 2011, BRAIN RES, V189, P209, DOI DOI 10.1016/B978-0-444-53884-0.00026-9
   Falck-Ytter T, 2008, AUTISM RES, V1, P297, DOI 10.1002/aur.45
   Falck-Ytter T, 2010, DEVELOPMENTAL SCI, V13, P864, DOI 10.1111/j.1467-7687.2009.00942.x
   Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Hernandez N, 2009, NEUROPSYCHOLOGIA, V47, P1004, DOI 10.1016/j.neuropsychologia.2008.10.023
   HOBSON RP, 1988, PSYCHOL MED, V18, P911
   Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
   Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142
   Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Koldewyn K., 2011, NEUROSCI BIOBEHAV R, V36, P1060, DOI [10.1016/j.neubiorev.2011.12.008, DOI 10.1016/J.NEUBI0REV.2011.12.008]
   LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x
   Monk CS, 2010, J PSYCHIATR NEUROSCI, V35, P105, DOI 10.1503/jpn.090085
   Morita T, 2012, SOC NEUROSCI-UK, V7, P223, DOI 10.1080/17470919.2011.598945
   Nakano T, 2010, P ROY SOC B-BIOL SCI, V277, P2935, DOI 10.1098/rspb.2010.0587
   Pellicano E, 2007, CURR BIOL, V17, P1508, DOI 10.1016/j.cub.2007.07.065
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
   Powell WR, 2009, LATERALITY, V14, P545, DOI 10.1080/13576500802680336
   Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7
   Salvucci D. D., 2000, P EYE TRACK RES APPL, P71, DOI DOI 10.1145/355017.355028
   SHIMOJO E, 2013, 13 ANN M VIS SCI SOC
   Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925
   van der Geest JN, 2002, J AUTISM DEV DISORD, V32, P69, DOI 10.1023/A:1014832420206
   Vlamings PHJM, 2010, CHILD DEV, V81, P1304, DOI 10.1111/j.1467-8624.2010.01470.x
NR 45
TC 2
Z9 2
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 1534-7362
J9 J VISION
JI J. Vision
PY 2013
VL 13
IS 10
DI 10.1167/13.10.5
PG 13
WC Ophthalmology
SC Ophthalmology
GA 247LB
UT WOS:000326617800005
ER

PT J
AU Ginsburg, F
   Rapp, R
AF Ginsburg, Faye
   Rapp, Rayna
BE Brenneis, D
   Strier, KB
TI Disability Worlds
SO ANNUAL REVIEW OF ANTHROPOLOGY, VOL 42
SE Annual Review of Anthropology
LA English
DT Article; Book Chapter
DE disability studies; impairment; embodiment; reflexivity
ID AUTISM; PERSPECTIVES; CHILDREN; GENDER; TECHNOLOGIES; ANTHROPOLOGY;
   IMPAIRMENT; SEXUALITY; HISTORY; KINSHIP
AB Disability is a profoundly relational category, shaped by social conditions that exclude full participation in society. What counts as an impairment in different sociocultural settings is highly variable. Recently, new approaches by disability scholars and activists show that disability is not simply lodged in the body, but created by the social and material conditions that "dis-able" the full participation of those considered atypical. Historically, anthropological studies of disability were often intellectually segregated, considered the province of those in medical and applied anthropology. We show the growing incorporation of disability in the discipline on its own terms by bringing in the social, activist, reflexive, experiential, narrative, and phenomenological dimensions of living with particular impairments. We imagine a broad future for critical anthropological studies of disability and argue that as a universal aspect of human life this topic should be foundational to the field.
C1 [Ginsburg, Faye; Rapp, Rayna] NYU, Dept Anthropol, New York, NY 10003 USA.
RP Ginsburg, F (reprint author), NYU, Dept Anthropol, New York, NY 10003 USA.
EM Faye.ginsburg@nyu.edu; rayna.rapp@nyu.edu
CR Ablon J., 1988, LIVING DIFFERENCE FA
   Ablon J., 2010, BRITTLE BONES STOUT
   Ablon Joan, 1984, LITTLE PEOPLE AM SOC
   Addlakha R, 2013, DISABILITY STUDIES I
   Angrosino M., 1997, OPPORTUNITY HOUSE ET
   ANGROSINO MV, 1994, J CONTEMP ETHNOGR, V23, P14, DOI 10.1177/089124194023001002
   Becker G., 1980, GROWING OLD SILENCE
   Berube M., 1996, LIFE WE KNOW IT FATH
   Biehl Joao Guilherme, 2005, VITA LIFE ZONE SOCIA
   Block P, 2000, SEX DISABIL, V18, P239, DOI 10.1023/A:1005642226413
   Block P., 2001, J DISABIL POLICY STU, V12, P18, DOI 10.1177/104420730101200103
   Blume S., 2009, ARTIFICIAL EAR COCHL
   Boellstorff T, 2008, COMING OF AGE IN SECOND LIFE: AN ANTHROPOLOGIST EXPLORES THE VIRTUALLY HUMAN, P1
   Bumiller K, 2008, SIGNS, V33, P967, DOI 10.1086/528848
   Canguilhem G., 1991, NORMAL PATHOLOGICAL
   Charlton JI., 1998, NOTHING DISABILITY O
   Cohen Lawrence, 1998, NO AGING INDIA ALZHE
   Cohen Lawrence, 2006, THINKING DEMENTIA CU
   Coleman EG, 2010, ANNU REV ANTHROPOL, V39, P487, DOI 10.1146/annurev.anthro.012809.104945
   Colligan SE, 1994, ANTHR WORK REV, V15, P5, DOI 10.1525/awr.1994.15.2-3.5
   Comfort Nathaniel, 2012, SCI HUMAN PERFECTION
   Couser G. Thomas, 2009, SIGNIFYING BODIES DI
   Crews Douglas E, 2006, J Physiol Anthropol, V25, P113, DOI 10.2114/jpa2.25.113
   Csordas T., 2002, BODY MEANING HEALING
   Cushing P., 2002, HYPATIA, V17, P173, DOI 10.2979/HYP.2002.17.3.173
   Cushing P., 2010, PARADOX DISABILITY R, P75
   Das V, 2001, PUBLIC CULTURE, V13, P511, DOI 10.1215/08992363-13-3-511
   Davis Lennard, 2013, DISABILITY STUDIES R
   Deshen SA., 1992, BLIND PEOPLE PRIVATE
   Devlieger P., 2003, RETHINKING DISABILIT
   Dossa P., 2009, RACIALIZED BODIES DI
   Drolsbaugh M., 2008, DEAF
   Edgerton R. B., 1967, CLOAK COMPETENCE STI
   Eide A., 2011, DISABILITY POVERTY G
   Fadiman A., 1998, SPIRIT CATCHES YOU Y
   Fine M., 1981, J SOCIOLOGY SOCIAL W, V8, P233
   Fineman MA., 2005, AUTONOMY MYTH THEORY
   Finger A., 1999, DUE STORY DISABILITY
   Fitzgerald MH, 1996, REHABILITATION ED, V10, P247
   Fjord L, 2009, HUM ORGAN, V68, P64
   Fjord LL., 1996, ANTHR HUMANISM, V21, P55, DOI 10.1525/ahu.1996.21.1.55
   Frank G., 2000, VENUS WHEELS 2 DECAD
   Franklin S, 2006, BORN MADE ETHNOGRAPH
   Friedner M., 2008, ECON POLIT WEEKLY, V43, P17
   Friedner M, 2010, SIGN LANGUAGE STUDIE, V10, P336
   Friedner M, 2013, ANTIPODE, V45, P43, DOI 10.1111/j.1467-8330.2012.00990.x
   Friedner M, 2012, SENSES SOC, V7, P72, DOI 10.2752/174589312X13173255802120
   Garland-Thomson Rosemarie, 2009, STARING WE LOOK
   Geurts KL, 2009, KORPER DINGE BEWEGUN, P97
   Ginsburg F., 2012, DIGITAL ANTHR, P101
   Ginsburg F, 2010, AM ANTHROPOL, V112, P518
   Goggin G, 2007, INFORM SOC, V23, P159, DOI 10.1080/01972240701323572
   Goggin G., 2003, DIGITAL DISABILITY S
   Gold G, 2008, ANTHR NEWS, V49, P27, DOI 10.1525/an.2008.49.4.27.2
   Greenhalgh S, 2001, MEDICAL GAZE FACTS F
   Grinker Roy Richard, 2007, UNSTRANGE MINDS REMA
   Grinker RR, 2010, ETHOS, V38, P172, DOI 10.1111/j.1548-1352.2009.01087.x
   Groce NE, 2000, AM ANTHROPOL, V102, P818, DOI 10.1525/aa.2000.102.4.818
   Groce NE, 1985, EVERYONE HERE SPOKE
   Gwaltney JL., 1970, THRICE SHY CULTURAL
   Habib D., 2009, INCLUDING SAMUEL DOC
   Haldane H., 2010, ANTHR TODAY, V26, P24, DOI DOI 10.1111/J.1467-8322.2010.00738.X
   Hiddinga A, 2011, LANG SOC, V40, P483, DOI 10.1017/S0047404511000480
   Hiddinga A, 2010, MED ANTHROPOL, V22, P225
   Hogle LF, 2005, ANNU REV ANTHROPOL, V34, P695, DOI 10.1146/annurev.anthro.33.070203.144020
   Holzer B, 2001, DISABILITY DIFFERENT
   Hubert J, 2010, MADNESS DISABILITY S
   Ingstad B., 1995, DISABILITY CULTURE
   Ingstad B., 2007, DISABILITY LOCAL GLO
   Ingstad Benedicte, 2007, DISABILITY LOCAL GLO, P33
   Jackson Jean E., 2000, CAMP PAIN TALKING CH
   Kasnitz D., 2001, DISABILITY STUDIES Q, V21, P2
   Kasnitz D., 2008, PRACTICING ANTHR, V30, P28
   Kaufman SR, 2010, ETHOS, V38, P8, DOI 10.1111/j.1548-1352.2009.01079.x
   Keating E, 2010, ANNU REV ANTHROPOL, V39, P115, DOI 10.1146/annurev.anthro.012809.105026
   Kent M., 2010, ROUTL STUD NEW MEDIA
   Kim Hall, 2011, FEMINIST DISABILITY
   Kittay E. F., 1999, LOVES LABOR ESSAYS W
   Kohrman M, 2005, BODIES OF DIFFERENCE: EXPERIENCES OF DISABILITY AND INSTITUTIONAL ADVOCACY IN THE MAKING OF MODERN CHINA, P1, DOI 10.1525/california/9780520226449.001.0001
   Kusters A, 2010, J DEAF STUD DEAF EDU, V15, P3, DOI 10.1093/deafed/enp026
   Laclave M, 2001, DISABIL STUD Q, V21, P152
   Ladd P., 2003, UNDERSTANDING DEAF C
   Landsman G., 2004, CONSUMING MOTHERHOOD, P100
   Landsman G., 2009, RECONSTRUCTING MOTHE
   Lane H., 1996, JOURNEY DEAF WORLD
   Lane Harlan, 1999, MASK BENEVOLENCE DIS
   Layne LL, 1996, MED ANTHROPOL Q, V10, P624, DOI 10.1525/maq.1996.10.4.02a00130
   Le Clair J., 2011, SPORT SOC, V14, P1300
   Le Clair J. M., 2011, SPORT SOC, V14, P1072
   Le Clair J.M, 2011, SPORT SOC, V14, P1116
   Linton S., 2005, MY BODY POLITIC MEMO
   Linton S., 1998, CLAIMING DISABILITY
   Livingston Julie, 2003, Med Anthropol, V22, P205, DOI 10.1080/01459740306771
   Livingston J, 2006, RADICAL HIST REV, P111
   Livingston J., 2005, DEBILITY MORAL IMAGI
   Lock M, 2006, PUBLIC UNDERST SCI, V15, P277, DOI 10.1177/0963662506059259
   Lock M., 1993, ENCOUNTERS AGING MYT
   Lock Margaret, 2002, TWICE DEAD ORGAN TRA
   Longmore P., 2001, NEW DISABILITY HIST
   MacMakin M, 2011, LAND OF THE UNCONQUERABLE: THE LIVES OF CONTEMPORARY AFGHAN WOMEN, P200
   Manderson L., 2011, SURFACE TENSIONS SUR
   Martin E, 2007, BIPOLAR EXPEDITION: MANIA AND DEPRESSION IN AMERICAN CULTURE, P1
   Mattingly C, 2010, PARADOX OF HOPE: JOURNEYS THROUGH A CLINICAL BORDERLAND, P1
   Mattingly C., 2000, NARRATIVE CULTURAL C
   Mattingly Cheryl, 1998, HEALING DRAMAS CLIN
   McRuer Robert, 2012, SEX DISABILITY
   Miller D., 2011, TALES FACEBOOK
   Monaghan Leila, 2003, MANY WAYS BE DEAF IN
   Murphy R., 2001, BODY SILENT DIFFEREN
   Myerhoff B., 1985, HER OWN TIME
   Nakamura K, 2009, HUM ORGAN, V68, P82
   Nakamura K., 2013, DISABILITY SOUL ETHN
   Nakamura Karen, 2010, BETHEL COMMUNITY SCH
   Nakamura Karen, 2006, DEAF JAPAN SIGNING P
   Nussbaum Martha, 2006, FRONTIERS JUSTICE DI
   Nussbaum M, 2001, NEW YORK REV BOOKS, V48, P34
   Ochs E, 2004, DISCOURSE STUD, V6, P147, DOI 10.1177/1461445604041766
   Ochs E, 2010, ETHOS, V38, P69, DOI 10.1111/j.1548-1352.2009.01082.x
   O'Toole CJ, 2002, SEX DISABIL, V20, P89, DOI 10.1023/A:1015290522277
   Panitch M., 2007, DISABILITY MOTHERS O
   Parens Erik, 2000, PRENATAL TESTING DIS
   Phillips S. D., 2011, DISABILITY MOBILE CI
   Priestley M., 2001, DISABILITY LIFE COUR
   Prince DE, 2010, ETHOS, V38, P56, DOI 10.1111/j.1548-1352.2009.01081.x
   Rapp R, 2011, ANTHROPOL QUART, V84, P379
   Rapp R, 2012, MED ANTHR INTERSECTI, P163
   Rapp R., 2000, TESTING WOMEN TESTIN
   Rapp R, 2007, REPROD DISRUPTIONS G, V11, P98
   Rapp R, 2001, PUBLIC CULTURE, V13, P533, DOI 10.1215/08992363-13-3-533
   Rapp R, 2011, IDENTITY STUD SOC SC, P166
   Roberts DE, 2009, SIGNS, V34, P783
   Rouse C, 2004, AM ETHNOL, V31, P514, DOI 10.1525/ae.2004.31.4.514
   Rouse CM, 2009, UNCERTAIN SUFFERING: RACIAL HEALTH CARE DISPARITIES AND SICKLE CELL DISEASE, P1
   Rousso H., 2013, DONT CALL ME INSPIRA
   Russell Marta, 2002, RAMPS DISABILITY END
   Samerski S, 2009, SIGNS, V34, P735
   Senghas RJ, 2002, ANNU REV ANTHROPOL, V31, P69, DOI 10.1146/annurev.anthro.31.020402.101302
   Shakespeare T, 2005, SOCIOL HEALTH ILL, V27, P138, DOI 10.1111/j.1467-9566.2005.00435.x
   Shakespeare Tom, 1998, DISABILITY READER SO
   Shapiro J. P., 1993, NO PITY PEOPLE DISAB
   Shuman A, 2011, J AM FOLKLORE, V124, P147
   Shuttleworth RP, 2004, MED ANTHROPOL Q, V18, P139, DOI 10.1525/maq.2004.18.2.139
   Silverman C, 2012, UNDERSTANDING AUTISM: PARENTS, DOCTORS, AND THE HISTORY OF A DISORDER, P1
   Silverman C, 2008, BIOSOCIETIES, V3, P325, DOI 10.1017/S1745855208006236
   Snyder SL, 2008, CAN J FILM STUD, V17, P11
   Solomon A, 2012, FAR TREE PARENTS CHI
   Solomon O, 2010, ANNU REV ANTHROPOL, V39, P241, DOI 10.1146/annurev.anthro.012809.105012
   Solomon O, 2010, ETHOS, V38, P143, DOI 10.1111/j.1548-1352.2009.01085.x
   Solomon O, 2010, ETHOS, V38, P1, DOI 10.1111/j.1548-1352.2009.01078.x
   Teruyama J., 2011, CTR ADV RES LOGIC SE, V12, P259
   Tilley L, 2011, INT J PALEOPATHOL, V1, P35, DOI 10.1016/j.ijpp.2011.02.003
   Trachtman I., 2008, PRAYING LIOR
   Varenne H., 1998, SUCCESSFUL FAILURE S
   Ville I, 2007, SCAND J DISABIL RES, V9, P138, DOI 10.1080/15017410701685877
   Wendell S., 1996, REJECTED BODY FEMINI
   Wentzell EA, 2012, MEDICAL ANTHR INTERS
   Winance M, 2009, DISABILITY SOC READE
NR 157
TC 1
Z9 1
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0084-6570
BN 978-0-8243-1942-7
J9 ANNU REV ANTHROPOL
JI Annu. Rev. Anthropol.
PY 2013
VL 42
BP 53
EP 68
DI 10.1146/annurev-anthro-092412-155502
PG 16
WC Anthropology
SC Anthropology
GA BHU69
UT WOS:000326694800005
ER

PT J
AU Kousoulidou, L
   Moutafi, M
   Nicolaides, P
   Hadjiloizou, S
   Christofi, C
   Paradesiotou, A
   Anastasiadou, V
   Sismani, C
   Patsalis, PC
AF Kousoulidou, Ludmila
   Moutafi, Maria
   Nicolaides, Paola
   Hadjiloizou, Stavros
   Christofi, Christos
   Paradesiotou, Anna
   Anastasiadou, Violetta
   Sismani, Carolina
   Patsalis, Philippos C.
TI Screening of 50 Cypriot Patients with Autism Spectrum Disorders or
   Autistic Features Using 400K Custom Array-CGH
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
AB Autism spectrum disorders (ASDs) comprise a distinct entity of neurodevelopmental disorders with a strong genetic component. Despite the identification of several candidate genes and causative genomic copy number variations (CNVs), the majority of ASD cases still remain unresolved. We have applied microarray-based comparative genomic hybridization (array-CGH) using Agilent 400K custom array in the first Cyprus population screening for identification of ASD-associated CNVs. A cohort of 50 ASD patients (G1), their parents (G2), 50 ethnically matched normal controls (G3), and 80 normal individuals having children with various developmental and neurological conditions (G4) were tested. As a result, 14 patients were found to carry 20 potentially causative aberrations, two of which were de novo. Comparison of the four population groups revealed an increased rate of rare disease-associated variants in normal parents of children with autism. The above data provided additional evidence, supporting the complexity of ASD aetiology in comparison to other developmental disorders involving cognitive impairment. Furthermore, we have demonstrated the rationale of a more targeted approach combining accurate clinical description with high-resolution population-oriented genomic screening for defining the role of CNVs in autism and identifying meaningful associations on the molecular level.
C1 [Kousoulidou, Ludmila; Moutafi, Maria; Anastasiadou, Violetta; Sismani, Carolina; Patsalis, Philippos C.] Cyprus Inst Neurol & Genet, CY-1683 Nicosia, Cyprus.
   [Nicolaides, Paola; Hadjiloizou, Stavros; Christofi, Christos] Cyprus Paediat Neurol Inst, CY-2047 Nicosia, Cyprus.
   [Paradesiotou, Anna; Anastasiadou, Violetta] Archbishop Makareios III Hosp, CY-2012 Nicosia, Cyprus.
RP Patsalis, PC (reprint author), Cyprus Inst Neurol & Genet, POB 23462, CY-1683 Nicosia, Cyprus.
EM patsalis@cing.ac.cy
FU Telethon Fund; European Regional Development Fund; Republic of Cyprus
   through the Research Promotion Foundation;  [gammaGammaEIA/0506/29]; 
   [gammaGammaEIA/DeltagammaGammaEIA/0308(BIE)/18]; 
   [PiPOSigmaBASigmaH/EPgammaETheta/ 0308/04]
FX The authors are grateful to all patients and volunteers for
   participating in the study and to the Cyprus Autism Association and the
   Cyprus Ministry of Education for assistance in patient recruitment. This
   work was funded by Telethon Fund 2009 and by Grant gamma Gamma
   EIA/0506/29, gamma Gamma EIA/Delta gamma Gamma EIA/0308(BIE)/18, and Pi
   PO Sigma BA Sigma H/EP gamma E Theta/ 0308/04, which are cofinanced by
   the European Regional Development Fund and the Republic of Cyprus
   through the Research Promotion Foundation.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Engel SM, 2011, EPIDEMIOLOGY, V22, P486, DOI 10.1097/EDE.0b013e31821daf1c
   Fombonne E, 2003, JAMA-J AM MED ASSOC, V289, P87, DOI 10.1001/jama.289.1.87
   Klei L, 2012, MOL AUTISM, V3
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Williams JM, 2009, AM J MED GENET A, V149A, P1758, DOI 10.1002/ajmg.a.32941
NR 9
TC 0
Z9 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2013
AR 843027
DI 10.1155/2013/843027
PG 5
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 247TV
UT WOS:000326645600001
ER

PT J
AU Ghanizadeh, A
AF Ghanizadeh, Ahmad
TI Increased Glutamate and Homocysteine and Decreased Glutamine Levels in
   Autism: A Review and Strategies for Future Studies of Amino Acids in
   Autism
SO DISEASE MARKERS
LA English
DT Review
ID SPECTRUM DISORDERS; OXIDATIVE STRESS; CHILDREN; PLASMA; SERUM;
   INFLAMMATION; PROFILES; FAMILIES; PARIETAL
AB There are many reports about the significant roles of some amino acids in neurobiology and treatment of autism. This is a critical review of amino acids levels in autism. No published review article about the level of amino acids in autism was found. The levels of glutamate and homocystein are increased in autism while the levels of glutamine and tryptophan are decreased. Findings regarding the plasma levels of taurine and lysine are controversial. The urinary levels of homocysteine and essential amino acids in both the untreated and treated autistic children are significantly less than those in the controls. The current literature suffers from many methodological shortcomings which needed to be considered in future studies. Some of them are age, gender, developmental level, autism symptoms severity, type of autism spectrum disorders, medical comorbidities, intelligent quotient, diet, concomitant medications, body mass index, and technical method of assessment of amino acids.
C1 [Ghanizadeh, Ahmad] Shiraz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Shiraz, Iran.
   [Ghanizadeh, Ahmad] Shiraz Univ Med Sci, Sch Med, Dept Psychiat, Shiraz, Iran.
RP Ghanizadeh, A (reprint author), Shiraz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Shiraz, Iran.
EM ghanizadeha@hotmail.com
CR Adams JB, 2006, J ALTERN COMPLEM MED, V12, P59, DOI 10.1089/acm.2006.12.59
   Ahearn WH, 2001, J AUTISM DEV DISORD, V31, P505, DOI 10.1023/A:1012221026124
   Aldred S, 2003, J AUTISM DEV DISORD, V33, P93, DOI 10.1023/A:1022238706604
   ALFREDSSON G, 1988, BIOL PSYCHIAT, V23, P689, DOI 10.1016/0006-3223(88)90052-2
   Ali A, 2011, ACTA BIOCHIM POL, V58, P547
   Arnold GL, 2003, J AUTISM DEV DISORD, V33, P449, DOI 10.1023/A:1025071014191
   Bienenstock J, 2010, CLIN EXP IMMUNOL, V160, P85, DOI 10.1111/j.1365-2249.2010.04124.x
   Blaylock RL, 2009, CURR MED CHEM, V16, P157
   Clayton TA, 2012, FEBS LETT, V586, P956, DOI 10.1016/j.febslet.2012.01.049
   Evans C, 2008, NUTR NEUROSCI, V11, P9, DOI 10.1179/147683008X301360
   Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0
   Fatemi SH, 2008, PROG NEURO-PSYCHOPH, V32, P911, DOI 10.1016/j.pnpbp.2007.11.004
   Ghanizadeh A, 2010, ARCH MED RES, V41, P651, DOI 10.1016/j.arcmed.2010.10.012
   Ghanizadeh A, 2012, J RES MED SCI, V17, P368
   Ghanizadeh A, 2011, INT J HYPERTHER, V27, P737, DOI 10.3109/02656736.2011.604665
   GHANIZADEH A, 2009, IRAN J PSYCHIAT, V4, P165
   Ghanizadeh A, 2011, NEUROCHEM RES, V36, P922, DOI 10.1007/s11064-010-0381-2
   Ghanizadeh A, 2012, CURR MED CHEM, V19, P4000
   GHANIZADEH A, 2010, INT J DEV NEUROSCIEN, V28
   Herndon AC, 2009, J AUTISM DEV DISORD, V39, P212, DOI 10.1007/s10803-008-0606-2
   James SJ, 2004, AM J CLIN NUTR, V80, P1611
   Johnson CR, 2008, J DEV PHYS DISABIL, V20, P437, DOI 10.1007/s10882-008-9111-y
   Kaluzna-Czaplinska J, 2011, ACTA BIOCHIM POL, V58, P31
   Kral T. V. E., 2013, J PEDIAT NURSING
   Levy SE, 2007, BIOL PSYCHIAT, V61, P492, DOI 10.1016/j.biopsych.2006.07.013
   Louis P, 2012, DIGEST DIS SCI, V57, P1987, DOI 10.1007/s10620-012-2286-1
   MacDermot KD, 2005, AM J HUM GENET, V76, P1074, DOI 10.1086/430841
   Mattila ML, 2010, J AUTISM DEV DISORD, V40, P1080, DOI 10.1007/s10803-010-0958-2
   Mazurek MO, 2013, J ABNORM CHILD PSYCH, V41, P165, DOI 10.1007/s10802-012-9668-x
   MORENO H, 1992, INVEST CLIN, V33, P13
   Moreno-Fuenmayor H, 1996, Invest Clin, V37, P113
   Page LA, 2006, AM J PSYCHIAT, V163, P2189, DOI 10.1176/appi.ajp.163.12.2189
   Pasca SP, 2006, LIFE SCI, V78, P2244, DOI 10.1016/j.lfs.2005.09.040
   PERRY TL, 1978, BIOL PSYCHIAT, V13, P575
   ROLF LH, 1993, ACTA PSYCHIAT SCAND, V87, P312, DOI 10.1111/j.1600-0447.1993.tb03378.x
   Schwarz E, 2011, MOL PSYCHIATR, V16, P1213, DOI 10.1038/mp.2010.102
   Sheldon AL, 2007, NEUROCHEM INT, V51, P333, DOI 10.1016/j.neuint.2007.03.012
   SHIMMURA C, 2011, PLOS ONE, V6
   Shinohe A, 2006, PROG NEURO-PSYCHOPH, V30, P1472, DOI 10.1016/j.pnpbp.2006.06.013
   Tidmarsh L, 2003, CAN J PSYCHIAT, V48, P517
   Tirouvanziam R, 2011, J AUTISM DEV DISORD, V42, P827, DOI 10.1007/s10803-011-1314-x
   Tu WJ, 2012, J CLIN BIOCHEM NUTR, V51, P248, DOI 10.3164/jcbn.12-45
   Zimmer MH, 2012, J AUTISM DEV DISORD, V42, P549, DOI 10.1007/s10803-011-1268-z
NR 43
TC 4
Z9 4
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2013
DI 10.1155/2013/536521
PG 6
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 238WW
UT WOS:000325983500001
PM 24167375
ER

PT J
AU Bilgic, A
   Congologlu, A
   Herguner, S
   Turkoglu, S
   Bahali, K
   Gurkan, K
   Durukan, I
   Turkbay, T
AF Bilgic, Ayhan
   Congologlu, Ayhan
   Herguner, Sabri
   Turkoglu, Serhat
   Bahali, Kayhan
   Gurkan, Kagan
   Durukan, Ibrahim
   Turkbay, Tumer
TI Use of Complementary and Alternative Medicine in Children with Autism
   Spectrum Disorders: A Multicenter Study
SO NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
LA English
DT Article
DE Autism spectrum disorder; autism; complementary and alternative
   medicine; treatment
ID PERVASIVE DEVELOPMENTAL DISORDERS; THERAPIES; FAMILIES; PARENTS
AB Introduction: This study examined the prevalence of the use of different complementary and alternative medicine (CAM) strategies, families' attitudes and belief systems about the use of these strategies, and the economic burden of these strategies placed on family income in families of children with autism spectrum disorders (ASD).
   Method: A questionnaire survey concerning the use of CAM in children with ASD was administered to parents in the five different geographic locations in Turkey.
   Results: Of the 172 respondents, 56% had used at least one CAM therapy. The most frequently used CAM intervention was spiritual healing. Among the most reported reasons for seeking CAM were dissatisfaction with conventional interventions and a search for ways to enhance the effectiveness of conventional treatments. The most frequently reported source of recommendation for CAM was advice from family members. The mean economic burden of the CAM methods was a total of 4,005 Turkish lira ($2,670) in the sample using CAM. The CAM usage rate was lower in parents who suspected genetic/congenital factors for the development of ASD.
   Conclusion: This study observed the importance of socioeconomic and cultural factors as well as parents' beliefs about the etiology of ASD in treatment decisions about CAM.
C1 [Bilgic, Ayhan; Herguner, Sabri] Selcuk Univ, Meram Sch Med, Dept Child & Adolescent Psychiat, Konya, Turkey.
   [Congologlu, Ayhan; Durukan, Ibrahim; Turkbay, Tumer] Gulhane Mil Med Acad, Dept Child & Adolescent Psychiat, Ankara, Turkey.
   [Turkoglu, Serhat] Ordu Govt Hosp, Dept Child & Adolescent Psychiat, Ordu, Turkey.
   [Bahali, Kayhan] Bakirkoy Prof Dr Mazhar Osman Mental Hlth & Neuro, Dept Child & Adolescent Psychiat, Istanbul, Turkey.
   [Gurkan, Kagan] Ankara Univ, Sch Med, Dept Child & Adolescent Psychiat, TR-06100 Ankara, Turkey.
RP Bilgic, A (reprint author), Selcuk Univ, Meram Sch Med, Dept Child & Adolescent Psychiat, Konya, Turkey.
EM bilgicayhan@yahoo.com
RI Bilgic, Ayhan/K-5936-2013
CR Akins RS, 2010, NEUROTHERAPEUTICS, V7, P307, DOI 10.1016/j.nurt.2010.05.002
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   [Anonymous], 1992, D ADAM PSIKIYATRI VE, V5, P24
   Astin JA, 1998, JAMA-J AM MED ASSOC, V279, P1548, DOI 10.1001/jama.279.19.1548
   Bilgic A, 2011, NOROPSIKIYATRI ARS, V48, P188, DOI 10.4274/Npa.Y5922
   Cohen MH, 2005, PEDIATRICS, V115, P774, DOI 10.1542/peds.2004-1093
   Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
   Hanson E, 2007, J AUTISM DEV DISORD, V37, P628, DOI 10.1007/s10803-006-0192-0
   Harrington JW, 2006, J DEV BEHAV PEDIA S2, V27, P156
   Kilincaslan A, 2011, NOROPSIKIYATRI ARS, V48, P94, DOI 10.4274/npa.y5591
   Lazoff T, 2010, CAN J PSYCHIAT, V55, P715
   Levy SE, 2005, MENT RETARD DEV D R, V11, P131, DOI 10.1002/mrdd.20062
   Levy SE, 2003, J DEV BEHAV PEDIATR, V24, P418, DOI 10.1097/00004703-200312000-00003
   Levy SE, 2003, PEDIATR ANN, V32, P685
   Liptak Gregory S, 2006, J Pediatr Health Care, V20, P245, DOI 10.1016/j.pedhc.2005.12.008
   Nickel RE, 1996, INFANT YOUNG CHILD, V8, P29
   Petry JJ, 2004, J ALTERN COMPLEM MED, V10, P939
   Sandler AD, 2001, PEDIATRICS, V107, P598
   Senel HG, 2010, J AUTISM DEV DISORD, V40, P494, DOI 10.1007/s10803-009-0891-4
   Sibinga EMS, 2004, CLIN PEDIATR, V43, P367, DOI 10.1177/000992280404300408
   Steyaert JG, 2008, EUR J PEDIATR, V167, P1091, DOI 10.1007/s00431-008-0764-4
   Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050
   Wong HHL, 2006, J AUTISM DEV DISORD, V36, P901, DOI 10.1007/s10803-006-0131-0
   Wong WC, 2009, J AUTISM DEV DISORD, V39, P454
NR 24
TC 0
Z9 0
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI CAD 22-2, FINDIKZADE, ISTANBUL 34093, TURKEY
SN 1300-0667
J9 NOROPSIKIYATRI ARS
JI Noropsikiyatri Ars.
PY 2013
VL 50
IS 3
BP 237
EP 243
DI 10.4274/Npa.y6389
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 238SM
UT WOS:000325969200008
ER

PT J
AU Vorsanova, SG
   Iourov, IY
   Kurinnaya, OS
   Voinova, VY
   Yurov, YB
AF Vorsanova, S. G.
   Iourov, I. Yu
   Kurinnaya, O. S.
   Voinova, V. Yu
   Yurov, Yu B.
TI Genomic abnormalities in children with mental retardation and autism:
   the use of comparative genomic hybridization in situ (HRCGH) and
   molecular karyotyping with DNA-microchips (array CGH)
SO ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA
LA Russian
DT Article
DE autism; mental retardation; genetic diagnostics; genome; DNA microarray;
   molecular karyotyping; comparative genomic hybridization; genomic and
   chromosome abnormalities
ID BRAIN
AB Genomic abnormalities occur with high frequency in children with mental retardation and autistic spectrum disorders (ADS). Molecular karyotyping using DNA microarrays is a new technology for diagnosis of genomic and chromosomal abnormalities in autism implemented in the fields of biological psychiatry and medical genetics. We carried out a comparative analysis of the frequency and spectrum of genome abnormalities in children with mental retardation and autism of unknown etiology using high-resolution comparative genomic methods for hybridization (HRCGH) and molecular karyotyping (array CGH). In a study of 100 children with autism, learning difficulties and congenital malformations by HRCGH, we identified genomic rearrangements in 46% of cases. Using array CGH we examined 50 children with autism. In 44 cases out of 50 (88%), different genomic abnormalities and genomic variations (CNV - copy number variations) were identified. Unbalanced genomic rearrangements, including deletions and duplications, were found in 23 cases out of 44 (52%). These data suggest that genomic abnormalities which are not detectable by common methods of chromosome analysis are often discovered by molecular cytogenetic techniques in children autism spectrum disorders. In addition, 54 children with idiopathic mental retardation and congenital malformations (31 boys and 23 girls) without autism spectrum disorders were examined using molecular karyotyping and microarray containing an increased number of DNA samples for genomic loci of chromosome X. Deletions and duplications affecting different regions of the chromosome X were detected in 11 out of 54 children (20.4%).
C1 [Vorsanova, S. G.] Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia.
   Moscow Res Inst Pediatris & Childrens Surg, Moscow, Russia.
   Moscow City Psychol & Pedag Univ, Moscow, Russia.
RP Vorsanova, SG (reprint author), Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia.
EM y_yurov@yahoo.com
RI Iourov, Ivan/O-7684-2014
OI Iourov, Ivan/0000-0002-4134-8367
CR Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
   [Anonymous], 2001, BRAIN DEV, V23, P196
   Bejjani BA, 2006, J MOL DIAGN, V8, P528, DOI 10.2353/jmoldx.2006.060029
   Emanuel BS, 2007, NAT REV GENET, V8, P869, DOI 10.1038/nrg2136
   Filges I., 2012, MOL CYTOGENET, V17, p[1, 38]
   Gao J., 2012, MOL CYTOGENET, V16, p[1, 33]
   Iourov IY, 2010, CURR GENOMICS, V11, P387, DOI 10.2174/138920210793176065
   Iourov I.Y., 2012, MOL CYTOGENET, V5, P46
   Iourov IY, 2009, HUM MOL GENET, V18, P2656, DOI 10.1093/hmg/ddp207
   Iourov I.Y., 2011, EUROPEAN J HUMAN GEN, V19, P135
   Iourov IY, 2008, CURR GENOMICS, V9, P452, DOI 10.2174/138920208786241216
   Mefford HC, 2012, NEW ENGL J MED, V366, P733, DOI 10.1056/NEJMra1114194
   Park S. J., 2011, MOL CYTOGENET, V9, P12
   Rafati M., 2012, MOL CYTOGENET, V29, P9
   Stankiewicz P, 2007, CURR OPIN GENET DEV, V17, P182, DOI 10.1016/j.gde.2007.04.009
   Tiganov AS, 2012, VESTNIK RAMN, V9, P45
   Valli R, 2011, MOL CYTOGENET, V9, P4
   Vorsanova S. C., 1998, AM J HUM GENET, V63, P154
   Vorsanova SG, 2010, MOL CYTOGENET, V3, DOI 10.1186/1755-8166-3-1
   Vorsanova SG, 2010, CURR GENOMICS, V11, P440, DOI 10.2174/138920210793176010
   Vorsanova SG, 1996, NEUROREPORT, V8, P187, DOI 10.1097/00001756-199612200-00038
   VORSANOVA SG, 2013, FUNDAENTAL RES, V4, P356
   VORSANOVA SG, 2008, GETEROKHROMATINOVYE, P300
   Vorsanova S G, 2005, Tsitol Genet, V39, P30
   YUROV IY, 2010, SLOZHNYE DIAGNOSTICH, P116
   YUROV IY, 2012, SOVREMENNYE PROBLEMY, P3
   Yurov YB, 2007, J MED GENET, V44, P521, DOI 10.1136/jmg.2007.049312
   YUROV YB, 2012, KLIN GENETIKA PERINA, V1, P50
   YUROV YB, 2005, KLIN LAB DIAGNOSTIKA, V11, P21
   YUROV YB, 2001, VESTN RAMN, V7, P26
NR 30
TC 1
Z9 1
PU IZDATELSTVO MEDITSINA
PI MOSCOW
PA PETROVERIGSKII PER 6-8, K-142 MOSCOW, RUSSIA
SN 1997-7298
J9 ZH NEVROL PSIKHIATR
JI Z. Nevrol. Psikhiatrii Im S S Korsakova
PY 2013
VL 113
IS 8
BP 46
EP 49
PG 6
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 242RQ
UT WOS:000326260100008
PM 24077551
ER

PT J
AU Paseual, R
   Bustamante, C
AF Paseual, Rodrigo
   Bustamante, Carlos
TI Early postweaning social isolation but not environmental enrichment
   modifies vermal Purkinje cell dendritic outgrowth in rats
SO ACTA NEUROBIOLOGIAE EXPERIMENTALIS
LA English
DT Article
DE Purkinje cell dendrites; environmental enrichment; social isolation;
   anxiety-like behaviors
ID ELEVATED PLUS-MAZE; CEREBELLAR CORTEX; PLASTICITY; EXERCISE; AUTISM;
   SYNAPTOGENESIS; ANGIOGENESIS; HYPERTROPHY; HIPPOCAMPUS; DISORDERS
AB In the present study, we analyzed the effects of enriched, social and isolated experiences on vermal Purkinje cell of the rat, together with anxiety-like behavior in the elevated-plus maze. Sprague-Dawley male rats were randomly submitted to either enriched, social, or isolated environments during the early postweaning period (postnatal days 22-32) and were then behaviorally evaluated in the elevated-plus maze and euthanized for histological analysis. Vermal Purkinje cells (sub-lobules VIa and VIb) were sampled, drawn under camera lucida and morphometrically assessed using the Sholl's concentric ring method. Data obtained indicate that environmental enrichment did not significantly modify the Purkinje cell dendritic branching. On the contrary, Purkinje cell of animals reared in social isolation exhibited a significant reduction in dendritic arborization, which was closely associated with anxiety-like behaviors. The data obtained indicate that, although environmental stimulation in normal animals does not produce significant changes in vermal Purkinje cell dendritic arborization, these cells are vulnerable to early stressful experiences, which is in close association with anxiety-like behaviors.
C1 [Paseual, Rodrigo; Bustamante, Carlos] Pontificia Univ Catolica Valparaiso, Fac Ciencias, Escuela Kinesiol, Lab Neurociencias, Valparaiso, Chile.
RP Paseual, R (reprint author), Pontificia Univ Catolica Valparaiso, Fac Ciencias, Escuela Kinesiol, Lab Neurociencias, Valparaiso, Chile.
EM rodrigo.pascual@ucv.cl
FU  [PUCV-VRIEA 127.706/2008]
FX This research was supported by Grant PUCV-VRIEA 127.706/2008
CR ANDERSON BJ, 1994, GLIA, V11, P73, DOI 10.1002/glia.440110110
   Anderson BJ, 1996, NEUROBIOL LEARN MEM, V66, P221, DOI 10.1006/nlme.1996.0062
   Beversdorf DQ, 2005, J AUTISM DEV DISORD, V35, P471, DOI 10.1007/s10803-005-5037-8
   BLACK JE, 1990, P NATL ACAD SCI USA, V87, P5568, DOI 10.1073/pnas.87.14.5568
   DelBello MP, 1999, NEUROPSYCHOPHARMACOL, V21, P63, DOI 10.1016/S0893-133X(99)00026-3
   Devonshire IM, 2010, NEUROSCIENCE, V170, P662, DOI 10.1016/j.neuroscience.2010.07.029
   DIAMOND MC, 1972, J NEUROBIOL, V3, P47, DOI 10.1002/neu.480030105
   Federmeier KD, 2002, NEUROSCI LETT, V332, P180, DOI 10.1016/S0304-3940(02)00759-0
   FLOETER MK, 1979, SCIENCE, V206, P227, DOI 10.1126/science.113873
   HEATH RG, 1978, BIOL PSYCHIAT, V13, P501
   HEATH RG, 1974, EXP NEUROL, V45, P268, DOI 10.1016/0014-4886(74)90118-6
   Ichimiya T, 2001, BIOL PSYCHIAT, V49, P20, DOI 10.1016/S0006-3223(00)01081-7
   Kaufmann WE, 2003, J CHILD NEUROL, V18, P463, DOI 10.1177/08830738030180070501
   Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004
   Kleim JA, 1997, NEUROBIOL LEARN MEM, V67, P29, DOI 10.1006/nlme.1996.3742
   Kleim JA, 1997, J NEUROSCI, V17, P717
   LARSELL O, 1952, J COMP NEUROL, V97, P281, DOI 10.1002/cne.900970204
   Leuner B, 2010, ANNU REV PSYCHOL, V61, P111, DOI 10.1146/annurev.psych.093008.100359
   Li M, 2012, AM J PSYCHIAT, V158, P952
   Mackie S, 2007, AM J PSYCHIAT, V164, P647, DOI 10.1176/appi.ajp.164.4.647
   McKay BE, 2005, J PHYSIOL-LONDON, V567, P829, DOI 10.1113/jphysiol.2005.089383
   Nithianantharajah J, 2006, NAT REV NEUROSCI, V7, P697, DOI 10.1038/nrn1970
   Pascual R, 1998, BIOL NEONATE, V73, P47, DOI 10.1159/000013959
   Pascual R, 1999, NEUROSCI LETT, V272, P171, DOI 10.1016/S0304-3940(99)00608-4
   PELLOW S, 1986, PHARMACOL BIOCHEM BE, V24, P525, DOI 10.1016/0091-3057(86)90552-6
   PYSH JJ, 1979, SCIENCE, V206, P230, DOI 10.1126/science.482938
   Sacchetti B, 2005, NEUROSCIENTIST, V11, P217, DOI 10.1177/1073858405276428
   Schutter DJLG, 2005, CEREBELLUM, V4, P290, DOI 10.1080/14734220500348584
   SHOLL DA, 1953, J ANAT, V87, P387
   Snider R S, 1976, Trans Am Neurol Assoc, V101, P295
   SUPPLE WF, 1990, BRAIN RES, V509, P17, DOI 10.1016/0006-8993(90)90303-S
   SUPPLE WF, 1990, BEHAV NEUROSCI, V104, P934
   Tavano A, 2007, BRAIN, V130, P2646, DOI 10.1093/brain/awm201
   van Praag H, 2000, NAT REV NEUROSCI, V1, P191, DOI 10.1038/35044558
   Walf AA, 2007, NAT PROTOC, V2, P322, DOI 10.1038/nprot.2007.44
   Will B, 2004, PROG NEUROBIOL, V72, P167, DOI 10.1016/j.pneurobio.2004.03.001
NR 36
TC 0
Z9 0
PU NENCKI INST EXPERIMENTAL BIOLOGY
PI WARSAW
PA UL PASTEURA 3, 02-093 WARSAW, POLAND
SN 0065-1400
EI 1689-0035
J9 ACTA NEUROBIOL EXP
JI Acta Neurobiol. Exp.
PY 2013
VL 73
IS 3
BP 387
EP 393
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 241YW
UT WOS:000326205600007
ER

PT J
AU Miller, J
   Ward, K
AF Miller, Jenny
   Ward, Karen
TI Academic-community partnerships in rural and frontier communities:
   improving services for children with autism and other developmental
   disabilities in Alaska
SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
LA English
DT Article
C1 [Miller, Jenny] Univ Alaska Anchorage, Dept Hlth Sci, Anchorage, AK 99508 USA.
   [Ward, Karen] Univ Alaska Anchorage, Ctr Human Dev, Anchorage, AK USA.
RP Miller, J (reprint author), Univ Alaska Anchorage, Dept Hlth Sci, Anchorage, AK 99508 USA.
EM jenny.miller@uaa.alaska.edu
CR Centers for Disease Control and Prevention, STRAT PLAN AUT SPECT
NR 1
TC 0
Z9 0
PU CO-ACTION PUBLISHING
PI JARFALLA
PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN
SN 1239-9736
EI 2242-3982
J9 INT J CIRCUMPOL HEAL
JI Int. J. Circumpolar Health
PY 2013
VL 72
SU 1
BP 395
EP 396
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 235LZ
UT WOS:000325721900123
ER

PT J
AU Troili, GM
   Businaro, R
   Massoni, F
   Ricci, L
   Petrone, L
   Ricci, P
   Ricci, S
AF Troili, G. M.
   Businaro, R.
   Massoni, F.
   Ricci, L.
   Petrone, L.
   Ricci, P.
   Ricci, S.
TI Investigation on a group of autistic children: risk factors and medical
   social considerations
SO CLINICA TERAPEUTICA
LA Italian
DT Article
DE autism; risk analysis; medical social considerations
ID SPECTRUM DISORDERS; AUTOIMMUNE-DISEASES; CORTICAL UNDERCONNECTIVITY;
   PESTICIDES; EXPOSURE; MERCURY; BEHAVIOR; WASTE; TASK; FMRI
AB Aims. The aim of this work is to study the association between autism in a group of autistic children and risk factors for specific familiar diseases and developmental disease in the early years of life, through a medical social investigation.
   Materials and Methods. For this study, we have submitted an anamnestic questionnaire to 29 autistic children and their families in a South Italy region (Basilicata), collecting data about children and their parents.
   Results. The results show that many children have a family history of autoimmune diseases (psoriasis, rheumatoid arthritis, celiac disease, Takayasu's arteritis), allergies and food intolerances, suggesting a putative involvement of the immune system in autism etiopathogenesis. Analyzing residences areas of patients, Potenza and Matera, with their environmental factors (radioactive waste repositories, incinerators, intensive farming), we demonstrate that the particular territorial characteristics don't affect autism.
   Conclusions. Autistic disorder is a spectrum of neurologic disorders complex both in etiopathogenesis and healthcare. So we aim to continue the study already undertaken on cytokines of autistic subjects serum and to extend it through biomolecular approaches assessing the presence of specific genetic polymorphisms in order to identify the physiopathogenetic mechanisms underlying the disease and to evaluate the predictive risk with the aim to improve care interventions.
C1 [Troili, G. M.; Massoni, F.; Ricci, L.; Petrone, L.; Ricci, P.; Ricci, S.] Univ Roma La Sapienza, Dipartimento Sci Anat Istol Med Legali & Apparato, Rome, Italy.
   [Businaro, R.] Univ Roma La Sapienza, Dipartimento Sci & Biotecnol Medicochirurg, Rome, Italy.
RP Ricci, S (reprint author), Univ Roma La Sapienza, Dipartimento Sci Anat Istol Med Legali & Apparato, Rome, Italy.
EM serafino.ricci@uniroma1.it
CR Agenzia regionale per la protezione dell'ambiente di basilicata (ARPAB) Dipartimento Provinciale di Potenza, 2011, CAMP MON CON CAMP PA
   AL-Ayadhi LY, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-158
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   [Anonymous], 2012, MED T PROM EKOL, V39, P8
   Atladottir HO, 2009, PEDIATRICS, V124, P687, DOI 10.1542/peds.2008-2445
   Bilbo SD, 2012, AUTISM RES TREAT, V2012
   Biri A, 2006, PLACENTA, V27, P327, DOI 10.1016/j.placenta.2005.01.002
   Boulanger LM, 2009, NEURON, V64, P93, DOI 10.1016/j.neuron.2009.09.001
   Braunschweig D, 2012, J AUTISM DEV DISORD, V42, P1435, DOI 10.1007/s10803-011-1378-7
   Bremer AA, 2012, PEDIATRICS
   Businaro R., 2012, CURR GERONTOL GERIAT, V2012, DOI DOI 10.1155/2012/986823
   Clarke C, 2012, HLTH ED RE
   Croen LA, 2005, ARCH PEDIAT ADOL MED, V159, P151, DOI 10.1001/archpedi.159.2.151
   Damarla SR, 2010, AUTISM RES, V3, P273, DOI 10.1002/aur.153
   Dhillon S, 2011, CURR GENOMICS, V12, P322, DOI 10.2174/138920211796429745
   Flore LA, 2012, SEMIN PEDIATR NEUROL, V19, P173, DOI 10.1016/j.spen.2012.09.004
   Gagnaire B, 2011, REV ENVIRON CONTAM T, V210, P35, DOI 10.1007/978-1-4419-7615-4_2
   Garay Paula A, 2010, Front Synaptic Neurosci, V2, P136, DOI 10.3389/fnsyn.2010.00136
   Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672
   Garrecht M, 2011, TOXICOL ENVIRON CHEM, V93, P1251, DOI 10.1080/02772248.2011.580588
   Geier DA, 2012, INT J ENV RES PUB HE, V9, P4486, DOI 10.3390/ijerph9124486
   Gerber JS, 2009, CLIN INFECT DIS, V48, P456, DOI 10.1086/596476
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   Istituto Nazionale di Economia Agraria (INEA), 2009, ASP EC AGR IRR BAS
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007
   Kalkbrenner AE, 2010, EPIDEMIOLOGY, V21, P631, DOI 10.1097/EDE.0b013e3181e65d76
   Keil A, 2010, EPIDEMIOLOGY, V21, P805, DOI 10.1097/EDE.0b013e3181f26e3f
   Kern JK, 2012, ACTA NEUROBIOL EXP, V72, P113
   Kim SM, 2010, PSYCHIAT INVEST, V7, P122, DOI 10.4306/pi.2010.7.2.122
   Kirillov V. F., 2010, Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, P8
   Kirkland A, 2012, SOC STUD SCI, V42, P237, DOI 10.1177/0306312711435832
   Kodavanti P.R., 2006, DOSE-RESPONSE, V3, P273
   Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326
   Mariussen E, 2003, NEUROCHEM INT, V43, P533, DOI 10.1016/S0197-0186(03)00044-5
   Massoni F, 2013, NEUROTOXICITY RES
   McGovern V, 2007, ENVIRON HEALTH PERSP, V115, pA504
   Mikhailov AI, 2005, MED T PROM EKOL, V11, P36
   Mrozek-Budzyn Dorota, 2011, Przegl Epidemiol, V65, P491
   Newschaffer CJ, 2002, EPIDEMIOL REV, V24, P137, DOI 10.1093/epirev.mxf010
   Nicoletti W, 1991, ARGOMENTI MED SOCIAL
   Pennesi CM, 2012, NUTR NEUROSCI, V15, P85, DOI 10.1179/1476830512Y.0000000003
   Polsek D, 2011, TRANSL NEUROSCI, V2, P256, DOI 10.2478/s13380-011-0024-3
   Ricci S, 2011, NEUROIMMUNOMODULAT, V18, P402
   Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
   Rosas LG, 2008, CURR OPIN PEDIATR, V20, P191, DOI 10.1097/MOP.0b013e3282f60a7d
   Sarra MV, 2012, ZACCHIA, V30, P189
   Schipul SE, 2011, FRONT SYST NEUROSCI, V22, P5
   Shelton JF, 2012, ENVIRON HEALTH PERSP, V120, P944, DOI 10.1289/ehp.1104553
   Sokolowski K, 2012, FRONT MOL NEUROSCI, V5, DOI 10.3389/fnmol.2012.00055
   Sul D, 2009, TOXICOLOGY, V255, P65, DOI 10.1016/j.tox.2008.10.006
   Tanne JH, 2012, BRIT MED J, V344, DOI 10.1136/bmj.e2768
   van Velzen D, 2002, WASTE MANAGE RES, V20, P556
   Viberg H, 2003, TOXICOL APPL PHARM, V192, P95, DOI 10.1016/S0041-008X(03)00217-5
   Wei HG, 2012, BBA-MOL BASIS DIS, V1822, P831, DOI 10.1016/j.bbadis.2012.01.011
NR 55
TC 0
Z9 0
PU SOC EDITRICE UNIV
PI ROME
PA VIA G B MORGAGNI 1, ROME, 10061, ITALY
SN 0009-9074
EI 1972-6007
J9 CLIN TER
JI Clin. Ter.
PY 2013
VL 164
IS 4
SU S
BP E273
EP E278
DI 10.7417/CT.2013.1587
PG 6
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 234CN
UT WOS:000325617700005
PM 24045522
ER

PT J
AU Oono, IP
   Honey, EJ
   McConachie, H
AF Oono, Inalegwu P.
   Honey, Emma J.
   McConachie, Helen
TI Parent-mediated early intervention for young children with autism
   spectrum disorders (ASD)
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; HOME-BASED INTERVENTION; INTENSIVE
   BEHAVIORAL TREATMENT; STONES TRIPLE P; DEVELOPMENTAL DELAY; JOINT
   ATTENTION; COMPREHENSIVE TREATMENTS; TRAINING INTERVENTION;
   PRESCHOOL-CHILDREN; PROGRAM
AB Background
   Young children with autism spectrum disorders (ASD) have impairments in the areas of communication and social interaction and often display repetitive or non-compliant behaviour. This early pattern of difficulties is a challenge for parents. Therefore, approaches that help parents develop strategies for interaction and management of behaviour are an obvious route for early intervention in ASD. This review updates a Cochrane review first published in 2002 but is based on a new protocol.
   Objectives
   To assess the effectiveness of parent-mediated early interventions in terms of the benefits for both children with ASD and their parents and to explore some potential moderators of treatment effect.
   Search methods
   We searched a range of psychological, educational and biomedical databases including CENTRAL, MEDLINE, Embase, PsycINFO and ERIC in August 2012. As this is an update of a previous review, we limited the search to the period following the original searches in 2002. Bibliographies and reference lists of key articles were searched, field experts were contacted and key journals were handsearched.
   Selection criteria
   We included only randomised controlled trials of early intervention for children with ASD. The interventions in the experimental condition were mediated by parents; the control conditions included no treatment, treatment as usual, waiting list, alternative child-centred intervention not mediated by parents, or alternative parent-mediated intervention of hypothesised lesser effect than the experimental condition.
   Data collection and analysis
   Two review authors (HM and IPO) independently screened articles identified in the search and decided which articles should be retrieved in full. For each included study, two review authors (IPO and EH) extracted and recorded data, using a piloted data collection form. Two review authors (IPO and HM) assessed the risk of bias in each study. We performed data synthesis and analysis using The Cochrane Collaboration's Review Manager 5.1 software.
   Main results
   The review includes 17 studies from six countries (USA, UK, Australia, Canada, Thailand and China), which recruited 919 children with ASD. Not all 17 studies could be compared directly or combined in meta-analyses due to differences in the theoretical basis underpinning interventions, the duration and intensity of interventions, and the outcome measurement tools used. Data from subsets of 10 studies that evaluated interventions to enhance parent interaction style and thereby facilitate children's communication were included in meta-analyses. The largest meta-analysis combined data from 316 participants in six studies and the smallest combined data from 55 participants in two studies. Findings from the remaining seven studies were reported narratively.
   High risk of bias was evident in the studies in relation to allocation concealment and incomplete outcome data; blinding of participants was not possible.
   Overall, we did not find statistical evidence of gains from parent-mediated approaches in most of the primary outcomes assessed (most aspects of language and communication -whether directly assessed or reported; frequency of child initiations in observed parent-child interaction; child adaptive behaviour; parents' stress), with findings largely inconclusive and inconsistent across studies. However, the evidence for positive change in patterns of parent-child interaction was strong and statistically significant (shared attention: standardised mean difference (SMD) 0.41; 95% confidence interval (CI) 0.14 to 0.68, P value < 0.05; parent synchrony: SMD 0.90; 95% CI 0.56 to 1.23, P value < 0.05). Furthermore, there is some evidence suggestive of improvement in child language comprehension, reported by parents (vocabulary comprehension: mean difference (MD 36.26; 95% CI 1.31 to 71.20, P value < 0.05). In addition, there was evidence suggesting a reduction in the severity of children's autism characteristics (SMD -0.30, 95% CI -0.52 to -0.08, P value < 0.05). However, this evidence of change in children's skills and difficulties as a consequence of parent-mediated intervention is uncertain, with small effect sizes and wide CIs, and the conclusions are likely to change with future publication of high-quality RCTs.
   Authors' conclusions
   The review finds some evidence for the effectiveness of parent-mediated interventions, most particularly in proximal indicators within parent-child interaction, but also in more distal indicators of child language comprehension and reduction in autism severity. Evidence of whether such interventions may reduce parent stress is inconclusive. The review reinforces the need for attention to be given to early intervention service models that enable parents to contribute skilfully to the treatment of their child with autism. However, practitioners supporting parent-mediated intervention require to monitor levels of parent stress. The ability to draw conclusions from studies would be improved by researchers adopting a common set of outcome measures as the quality of the current evidence is low.
C1 [Oono, Inalegwu P.; McConachie, Helen] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
   [Honey, Emma J.] Northumberland Tyne & Wear NHS Fdn Trust, Complex Neurodev Disorders Serv, Newcastle Upon Tyne, Tyne & Wear, England.
RP McConachie, H (reprint author), Newcastle Univ, Inst Hlth & Soc, Sir James Spence Inst, Victoria Rd, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
EM h.r.mcconachie@newcastle.ac.uk
FU The Nuffield Foundation, UK
FX External sourcesThe Nuffield Foundation, UK.
CR Adamson LB, 2004, CHILD DEV, V75, P1171, DOI 10.1111/j.1467-8624.2004.00732.x
   Aldred C, 2012, J AUTISM DEV DISORD, V42, P447, DOI 10.1007/s10803-011-1248-3
   Aldred C, 2004, J CHILD PSYCHOL PSYC, V45, P1420, DOI 10.1111/j1469-7610.2004.00338.x
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Balkom H, 2010, CHILD LANG TEACH THE, V23, P221
   Boyd AB, 2011, J EARLY INTERVENTION, V32, P75
   Brozek J, 2008, GRADEPRO 3 2 WINDOWS
   Carter AS, 2011, J CHILD PSYCHOL PSYC, V52, P741, DOI 10.1111/j.1469-7610.2011.02395.x
   Casenhiser DM, 2013, AUTISM, V17, P220, DOI 10.1177/1362361311422052
   Charman T, 2010, FOLIA PHONIATR LOGO, V62, P166, DOI 10.1159/000314032
   Cunningham AB, 2012, J AUTISM DEV DISORD, V42, P593, DOI 10.1007/s10803-011-1280-3
   Dawson G, 1997, EFFECTIVENESS EARLY, V102, P319
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Diggle T., 2002, COCHRANE DB SYST REV, V2002, DOI [10.1002/14651858, DOI 10.1002/14651858.CD003496]
   Drew A, 2002, EUR CHILD ADOLES PSY, V11, P266, DOI 10.1007/s00787-002-0299-6
   Eldevik S, 2009, J CLIN CHILD ADOLESC, V38, P439, DOI 10.1080/15374410902851739
   Frankel F, 2010, J AUTISM DEV DISORD, V40, P843
   Gantman A, 2012, J AUTISM DEV DISORD, V42, P1094, DOI 10.1007/s10803-011-1350-6
   Giarelli Ellen, 2005, Pediatr Nurs, V31, P389
   Green J, 2010, LANCET, V375, P2152, DOI 10.1016/S0140-6736(10)60587-9
   Gulsrud AC, 2010, J AUTISM DEV DISORD, V40, P227, DOI 10.1007/s10803-009-0861-x
   Higgins JPT, 2011, COCHRANE HDB SYSTEMA
   Howlin P, 1987, TREATMENT AUTISTIC C
   Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41
   Jocelyn LJ, 1998, J DEV BEHAV PEDIATR, V19, P326, DOI 10.1097/00004703-199810000-00002
   Kaale A, 2012, J CHILD PSYCHOL PSYC, V53, P97, DOI 10.1111/j.1469-7610.2011.02450.x
   Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x
   Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
   Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5
   Koegel R. L., 1995, TEACHING CHILDREN AU
   Koegel RL, 1996, J AUTISM DEV DISORD, V26, P347, DOI 10.1007/BF02172479
   Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
   Lopata C, 2010, J AUTISM DEV DISORD, V40, P1297, DOI 10.1007/s10803-010-0989-8
   Lord C, 1994, PRESCHOOL ED PROGRAM
   Lovaas O. I., 1981, TEACHING DEV DISABLE
   Magiati I, 2011, RES AUTISM SPECT DIS, V5, P1016, DOI 10.1016/j.rasd.2010.11.007
   McConachie H, 2005, J PEDIATR-US, V147, P335, DOI 10.1016/j.jpeds.2005.03.056
   MCEACHIN JJ, 1993, AM J MENT RETARD, V97, P359
   Nefdt N, 2010, J POSIT BEHAV INTERV, V12, P23, DOI 10.1177/1098300709334796
   Oosterling I, 2010, J AUTISM DEV DISORD, V40, P1447, DOI 10.1007/s10803-010-1004-0
   Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
   Pajareya K, 2011, AUTISM, V15, P563, DOI 10.1177/1362361310386502
   Prizant B M, 1997, HDB AUTISM PERVASIVE
   Prizant Barry, 1998, Seminars in Speech and Language, V19, P329, DOI 10.1055/s-2008-1064053
   Reichow B, 2012, J AUTISM DEV DISORD, V42, P512, DOI 10.1007/s10803-011-1218-9
   Reuters Thomson, ENDNOTE WEB VERS X5
   Rickards AL, 2007, J DEV BEHAV PEDIATR, V28, P308, DOI 10.1097/DBP.0b013e318032792e
   Rickards AL, 2009, CHILD CARE HLTH DEV, V35, P593, DOI 10.1111/j.1365-2214.2009.00953.x
   Roberts J, 2011, RES AUTISM SPECT DIS, V5, P1553, DOI 10.1016/j.rasd.2011.03.001
   ROGERS SJ, 1991, TOP EARLY CHILD SPEC, V11, P29
   Rogers SJ, 1998, J CLIN CHILD PSYCHOL, V27, P168, DOI 10.1207/s15374424jccp2702_4
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Rogers SJ, 1998, MENT RETARD DEV D R, V4, P104
   Romski M, 2010, J SPEECH LANG HEAR R, V53, P350, DOI 10.1044/1092-4388(2009/08-0156)
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   SCHOPLER E, 1971, J AUTISM CHILD SCHIZ, V1, P87, DOI 10.1007/BF01537746
   Shin JY, 2009, J INTELL DISABIL RES, V53, P339, DOI 10.1111/j.1365-2788.2008.01151.x
   Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771
   Siller M, 2012, J AUTISM DEV DISORDE
   Silva LMT, 2009, AM J OCCUP THER, V63, P423
   Silva LMT, 2011, AM J OCCUP THER, V65, P550, DOI 10.5014/ajot.2011.000661
   Smith IM, 2010, AJIDD-AM J INTELLECT, V115, P504, DOI [10.1352/1944-7558-115.6.504, 10.1352/194475581156504]
   Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
   Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
   Smith T, 1999, CLIN PSYCHOL-SCI PR, V6, P33, DOI 10.1093/clipsy/6.1.33
   Sofronoff K, 2011, RES DEV DISABIL, V32, P2253, DOI 10.1016/j.ridd.2011.07.046
   Sung M, 2011, CHILD PSYCHIAT HUM D, V42, P634, DOI 10.1007/s10578-011-0238-1
   Tang MH, 2011, J CHIN MED ASSOC, V74, P259, DOI 10.1016/j.jcma.2011.04.005
   The Nordic Cochrane Centre The Cochrane Collaboration, 2011, REV MAN REVMAN 5 1
   Tonge B, AUTISM IN PRESS
   Tonge B, 2006, J AM ACAD CHILD PSY, V45, P561, DOI 10.1097/01.chi.0000205701.48324.26
   Turner LM, 2007, J CHILD PSYCHOL PSYC, V48, P793, DOI 10.1111/j.1469-7610.2007.01744.x
   Vriend JL, 2011, J PEDIATR PSYCHOL, V36, P1017, DOI 10.1093/jpepsy/jsr044
   Warren Z., 2011, COMP EFFECTIVENESS R, V26
   Warreyn P, SEE WHAT I SEE DO I
   Whalen C, 2010, AUTISM, V14, P179, DOI 10.1177/1362361310363282
   Whittingham K, 2009, J ABNORM CHILD PSYCH, V37, P469, DOI 10.1007/s10802-008-9285-x
   Wong VCN, 2010, J AUTISM DEV DISORD, V40, P677, DOI 10.1007/s10803-009-0916-z
   World Health Organization, 2014, INT CLASS DIS REL HL
   Yoder P, 2006, J CONSULT CLIN PSYCH, V74, P426, DOI 10.1037/0022-006X.74.3.426
NR 81
TC 5
Z9 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2013
IS 4
AR CD009774
DI 10.1002/14651858.CD009774.pub2
PG 101
WC Medicine, General & Internal
SC General & Internal Medicine
GA 167SK
UT WOS:000320654500034
ER

PT J
AU Brentani, H
   de Paula, CS
   Bordini, D
   Rolim, D
   Sato, F
   Portolese, J
   Pacifico, MC
   McCracken, JT
AF Brentani, Helena
   de Paula, Cristiane Silvestre
   Bordini, Daniela
   Rolim, Deborah
   Sato, Fabio
   Portolese, Joana
   Pacifico, Maria Clara
   McCracken, James T.
TI Autism spectrum disorders: an overview on diagnosis and treatment
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE Autistic disorder; pervasive development disorders; diagnosis, treatment
ID PERVASIVE DEVELOPMENTAL DISORDERS; PLACEBO-CONTROLLED TRIAL; DEFICIT
   HYPERACTIVITY DISORDER; DOUBLE-BLIND; BEHAVIORAL SYMPTOMS; REPETITIVE
   BEHAVIORS; LANGUAGE IMPAIRMENT; PRESCHOOL-CHILDREN; CROSSOVER TRIAL;
   RATING-SCALE
AB Pervasive developmental disorders are now commonly referred to as autism spectrum disorders (ASDs). ASDs present with a range of severity and impairments, and often are a cause of severe disability, representing a major public health concern. The diagnostic criteria require delays or abnormal functioning in social interaction, language, and/or imaginative play within the first 3 years of life, resulting in a deviation from the developmental pattern expected for the age. Because establishing a diagnosis of ASD is possible as early as 18-24 months of age, clinicians should strive to identify and begin intervention in children with ASD as soon as signs are manifest. Increasing efforts are underway to make ASD screening universal in pediatric healthcare. Given the crucial importance of early identification and multiple modalities of treatment for ASD, this review will summarize the diagnostic criteria, key areas for assessment by clinicians, specific scales and instruments for assessment, and discussion of evidence-based treatment programs and the role of specific drug therapies for symptom management.
C1 [Brentani, Helena] Univ Sao Paulo, Sch Med, Dept Psychiat, BR-05403010 Sao Paulo, Brazil.
   [Brentani, Helena; Rolim, Deborah; Sato, Fabio; Portolese, Joana; Pacifico, Maria Clara] Univ Sao Paulo, Sch Med, Inst Psychiat, Autism Spectrum Program, BR-05403010 Sao Paulo, Brazil.
   [de Paula, Cristiane Silvestre; Bordini, Daniela] Univ Fed Sao Paulo, Dept Psychiat, Child & Adolescent Psychiat Unit, Sao Paulo, Brazil.
   [de Paula, Cristiane Silvestre] Univ Presbiteriana Mackenzie, Hlth & Biol Sci Ctr, Grad Program Dev Disorders, Sao Paulo, Brazil.
   [McCracken, James T.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
RP Brentani, H (reprint author), Univ Sao Paulo, Rua Dr Ovidio Pires Campos S-N, BR-05403010 Sao Paulo, Brazil.
EM helena.brentani@gmail.com
FU Seaside Therapeutics; Roche; Otsuka
FX James T. McCracken receives a research grant from Seaside Therapeutics,
   Roche, and Otsuka, works as a consultant for Roche, and has some works
   with Roche and Novartis. The other authors report no conflicts of
   interest.
CR AMAN MG, 1985, AM J MENT DEF, V89, P485
   Aman MG, 2008, J CHILD ADOL PSYCHOP, V18, P227, DOI 10.1089/cap.2007.0133
   Aman MG, 2003, J AUTISM DEV DISORD, V33, P527, DOI 10.1023/A:1025883612879
   Aman MG, 2008, CHILD ADOL PSYCH CL, V17, P713, DOI 10.1016/j.chc.2008.06.009
   American Psychiatric Association, 2002, MAN DIAGN EST TRANST
   ANDERSON LT, 1984, AM J PSYCHIAT, V141, P1195
   ANDERSON LT, 1989, J AUTISM DEV DISORD, V19, P227, DOI 10.1007/BF02211843
   [Anonymous], 2009, MMWR SURVEILL SUMM, V58, P1
   [Anonymous], 2007, MMWR SURVEILL SUMM, V56, P12
   Baghdadli A, 2003, J INTELL DISABIL RES, V47, P622, DOI 10.1046/j.1365-2788.2003.00507.x
   Barbaro J, 2010, J DEV BEHAV PEDIATR, V31, P376, DOI 10.1097/DBP.0b013e3181df7f3c
   Becker MM, 2012, ARQ NEURO-PSIQUIAT, V70, P185, DOI 10.1590/S0004-282X2012000300006
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Bishop D., 2000, SPEECH LANGUAGE IMPA, P99
   Bishop DVM, 2010, BEHAV GENET, V40, P618, DOI 10.1007/s10519-010-9381-x
   Boltor PF, 2011, BRIT J PSYCHIAT, V198, P289, DOI 10.1192/bjp.bp.109.076877
   Bonanno DG, 2001, ANN PHARMACOTHER, V35, P563
   Canitano R, 2011, PROG NEURO-PSYCHOPH, V35, P18, DOI 10.1016/j.pnpbp.2010.10.015
   Chen NC, 2001, J CLIN PSYCHIAT, V62, P479
   Cohen SA, 2004, J CLIN PSYCHIAT, V65, P110
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Cooper J. O., 2007, APPL BEHAV ANAL
   Corcoran J, 2000, RES SOCIAL WORK PRAC, V10, P547
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P1339, DOI 10.1007/s10803-009-0750-3
   Eugene Arnold L, 2012, EVID BASED MENT HLTH, V15, P96
   Fiedorowicz JG, 2012, CURR PSYCHIAT REV, V8, P25
   Fombonne E., 2006, UNDERSTANDING AUTISM, P25
   Fombonne E, 2009, J AM ACAD CHILD PSY, V48, P463, DOI 10.1097/CHI.0b013e31819e40c0
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Forehand R., 2002, J CHILD FAM STUD, V11, P377, DOI 10.1023/A:1020913422609
   Frith U, 2003, PHILOS T R SOC B, V358, P459, DOI 10.1098/rstb.2002.1218
   Frye RE, 2011, BMC PEDIATR, V11, DOI 10.1186/1471-2431-11-37
   Gencer O, 2008, EUR CHILD ADOLES PSY, V17, P217, DOI 10.1007/s00787-007-0656-6
   Ghaziuddin M., 1992, EUROPEAN CHILD ADOLE, V1, P209
   Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68
   Gray KM, 2005, AUST NZ J PSYCHIAT, V39, P378, DOI 10.1111/j.1440-1614.2005.01585.x
   Guerreiro MM, 2009, TRATADO FONOAUDIOLOG, P323
   Gurrieri F, 2012, AM J MED GENET C, V160C, P104, DOI 10.1002/ajmg.c.31326
   Guthrie W, 2012, J CHILD PSYCHOL PSYC
   Handen BL, 2000, J AUTISM DEV DISORD, V30, P245, DOI 10.1023/A:1005548619694
   Harfterkamp M, 2012, J AM ACAD CHILD PSY, V51, P733, DOI 10.1016/j.jaac.2012.04.011
   Heimann SW, 1999, J AM ACAD CHILD PSY, V38, P496, DOI 10.1097/00004583-199905000-00004
   Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627
   Hollander E, 2012, AM J PSYCHIAT, V169, P292, DOI 10.1176/appi.ajp.2011.10050764
   Hollander E, 2010, NEUROPSYCHOPHARMACOL, V35, P990, DOI 10.1038/npp.2009.202
   Horrigan JP, 1997, J AM ACAD CHILD PSY, V36, P1166, DOI 10.1097/00004583-199709000-00007
   Kaplan G, 2012, PEDIATR CLIN N AM, V59, P175, DOI 10.1016/j.pcl.2011.10.005
   King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30
   Klin Ami, 2006, Rev Bras Psiquiatr, V28 Suppl 1, pS3, DOI 10.1590/S1516-44462006000500002
   Kolevzon A, 2006, J CLIN PSYCHIAT, V67, P407
   KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
   Lecavalier L, 2006, J AUTISM DEV DISORD, V36, P1101, DOI 10.1007/s10803-006-0147-5
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2004, J CHILD PSYCHOL PSYC, V45, P936, DOI 10.1111/j.1469-7610.2004.t01-1-00287.x
   Lotter V., 1966, SOC PSYCHIAT, P124, DOI DOI 10.1007/BF00584048
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Luby J, 2006, J CHILD ADOL PSYCHOP, V16, P575, DOI 10.1089/cap.2006.16.575
   Malone RP, 2001, J AM ACAD CHILD PSY, V40, P887, DOI 10.1097/00004583-200108000-00009
   Malone RP, 2007, J CHILD ADOL PSYCHOP, V17, P779, DOI 10.1089/cap.2006.0126
   Malow Beth A, 2012, Pediatrics, V130 Suppl 2, pS106, DOI 10.1542/peds.2012-0900I
   Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658
   Martin A, 1999, J CHILD ADOL PSYCHOP, V9, P99, DOI 10.1089/cap.1999.9.99
   McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P1001
   McDougle CJ, 2008, J CLIN PSYCHIAT, V69, P15
   McDougle CJ, 2002, J AM ACAD CHILD PSY, V41, P921, DOI 10.1097/00004583-200208000-00010
   McGregor KK, 2012, J AUTISM DEV DISORD, V42, P35, DOI 10.1007/s10803-011-1210-4
   Miral S, 2008, EUR CHILD ADOLES PSY, V17, P1, DOI 10.1007/s00787-007-0620-5
   Nagaraj R, 2006, J CHILD NEUROL, V21, P450, DOI 10.2310/7010.2006.00099
   National Research Council, 2001, ED CHILDR AUT
   Nazzer A., 2011, PEDIATR CLIN N AM, V58, P85
   Nikolov R, 2006, REV BRAS PSIQUIATR, V28, pS39, DOI 10.1590/S1516-44462006000500006
   Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
   Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Ozonoff S, 2012, J CHILD PSYCHOL PSYC, V53, P1092, DOI 10.1111/j.1469-7610.2012.02614.x
   Pandina GJ, 2007, J AUTISM DEV DISORD, V37, P367, DOI 10.1007/s10803-006-0234-7
   Pastorello LM, 1996, FONOAUDIOLOGIA DISTU, P45
   Paul R., 2008, AUTISM SPECTRUM DISO, P76
   Paul R, 2007, J SPEECH LANG HEAR R, V50, P1350, DOI 10.1044/1092-4388(2007/094)
   Paul R., 2011, TXB AUTISM SPECTRUM, P147
   Paul R., 2007, LANGUAGE DISORDERS D, P163
   Paula CS, 2011, J AUTISM DEV DISORD, V41, P1738, DOI 10.1007/s10803-011-1200-6
   Perissinoto J., 2003, CONHECIMENTOS ESSENT
   Pickett E, 2009, COGN BEHAV NEUROL, V22, P1, DOI 10.1097/WNN.0b013e318190d185
   Potenza MN, 1999, J CLIN PSYCHOPHARM, V19, P37, DOI 10.1097/00004714-199902000-00008
   QUINTANA H, 1995, J AUTISM DEV DISORD, V25, P283, DOI 10.1007/BF02179289
   Reaven J, 2012, J CHILD PSYCHOL PSYC, V53, P410, DOI 10.1111/j.1469-7610.2011.02486.x
   Reisinger LM, 2011, J AUTISM DEV DISORD, V41, P1694, DOI 10.1007/s10803-011-1196-y
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266
   Rezaei V, 2010, PROG NEURO-PSYCHOPH, V34, P1269, DOI 10.1016/j.pnpbp.2010.07.005
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
   Rossignol DA, 2011, DEV MED CHILD NEUROL, V53, P783, DOI 10.1111/j.1469-8749.2011.03980.x
   Schopler E., 1986, CHILDHOOD AUTISM RAT
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Shea S, 2004, PEDIATRICS, V114, pE634, DOI 10.1542/peds.2003-0264-F
   Siegel M, 2012, J AUTISM DEV DISORD, V42, P1592, DOI 10.1007/s10803-011-1399-2
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Soorya L, 2008, CHILD ADOL PSYCH CL, V17, P753, DOI 10.1016/j.chc.2008.06.003
   Soorya LV, 2011, TXB AUTISM SPECTRUM, P525
   Souders MC, 2009, SLEEP, V32, P1566
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Sun Jing, 2012, Int J Adolesc Med Health, V24, P291, DOI 10.1515/ijamh.2012.042
   Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335
   Tomblin B, 2011, INT J LANG COMM DIS, V46, P127, DOI 10.1111/j.1460-6984.2011.00017.x
   Troost PW, 2005, J AM ACAD CHILD PSY, V44, P1137, DOI 10.1097/01.chi.0000177055.11229.76
   Vismara LA, 2010, ANNU REV CLIN PSYCHO, V6, P447, DOI 10.1146/annurev.clinpsy.121208.131151
   Volkmar FR, 2008, WORLD PSYCHIATRY, V7, P19
   Warren Z, 2011, AGENCY HEALTHCARE RE
   Wetherby A. M., 2008, AUTISM SPECTRUM DISO, P170
   Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y
   Whitehouse AJO, 2007, J CHILD PSYCHOL PSYC, V48, P822, DOI 10.1111/j.1469-7610.2007.01765.x
   Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x
   Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606
NR 119
TC 5
Z9 5
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PY 2013
VL 35
SU 1
BP S62
EP S72
DI 10.1590/1516-4446-2013-S104
PG 11
WC Psychiatry
SC Psychiatry
GA 235SX
UT WOS:000325742100008
PM 24142129
ER

PT J
AU Siniscalco, D
   Bradstreet, JJ
   Sych, N
   Antonucci, N
AF Siniscalco, Dario
   Bradstreet, James Jeffrey
   Sych, Nataliia
   Antonucci, Nicola
TI Perspectives on the Use of Stem Cells for Autism Treatment
SO STEM CELLS INTERNATIONAL
LA English
DT Review
ID MESENCHYMAL STROMAL CELLS; AMNIOTIC EPITHELIAL-CELLS; SPECTRUM
   DISORDERS; CELLULAR-THERAPY; IMMUNOMODULATORY PROPERTIES; REGENERATIVE
   MEDICINE; INTERNATIONAL-SOCIETY; NEUROTROPHIC FACTORS; PURKINJE-CELLS;
   PLURIPOTENCY
AB Autism and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders. ASDs are clinically defined by deficits in communication, social skills, and repetitive and/or restrictive interests and behaviours. With the prevalence rates for ASDs rapidly increasing, the need for effective therapies for autism is a priority for biomedical research. Currently available medications do not target the core symptoms, can have markedly adverse side-effects, and are mainly palliative for negative behaviours. The development of molecular and regenerative interventions is progressing rapidly, and medicine holds great expectations for stem cell therapies. Cells could be designed to target the observed molecular mechanisms of ASDs, that is, abnormal neurotransmitter regulation, activated microglia, mitochondrial dysfunction, blood-brain barrier disruptions, and chronic intestinal inflammation. Presently, the paracrine, secretome, and immunomodulatory effects of stem cells would appear to be the likely mechanisms of application for ASD therapeutics. This review will focus on the potential use of the various types of stem cells: embryonic, induced pluripotential, fetal, and adult stem cells as targets for ASD therapeutics.
C1 [Siniscalco, Dario] Univ Naples 2, Dept Expt Med, I-80138 Naples, Italy.
   [Siniscalco, Dario] La Forza Silenzio, Ctr Autism, I-81036 Caserta, Italy.
   [Siniscalco, Dario] Cancellautismo, I-50132 Florence, Italy.
   [Bradstreet, James Jeffrey] Chateau Elan, Int Child Dev Resource Ctr, Braselton, GA 30517 USA.
   [Sych, Nataliia] Cell Therapy Ctr EmCell, Clin Dept, UA-04073 Kiev, Ukraine.
   [Antonucci, Nicola] Biomed Ctr Autism Res & Treatment, I-70126 Bari, Italy.
RP Siniscalco, D (reprint author), Univ Naples 2, Dept Expt Med, Via S Maria di Costantinopoli 16, I-80138 Naples, Italy.
EM dariosin@uab.edu
CR Abdulrazzak H, 2010, J R SOC INTERFACE, V7, pS689, DOI 10.1098/rsif.2010.0347.focus
   Aleckovic M, 2008, REPROD BIOMED ONLINE, V17, P270
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Aronin CEP, 2010, BIRTH DEFECTS RES C, V90, P67, DOI 10.1002/bdrc.20174
   Arthur A, 2009, J CELL PHYSIOL, V218, P237, DOI 10.1002/jcp.21592
   Ashwood P, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019299
   Aznar J, 2011, J PHYSIOL BIOCHEM, V67, P141, DOI 10.1007/s13105-010-0064-0
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Bernstein P, 2013, BIOTECHNOL PROGR, V29, P206, DOI 10.1002/btpr.1668
   Beyer Nardi N, 2006, HANDB EXP PHARM, V174, P249
   Blake J., 2013, S DAKOTA MED
   Blum B, 2008, ADV CANCER RES, V100, P133, DOI 10.1016/S0065-230X(08)00005-5
   Bradstreet JJ, 2010, ALTERN MED REV, V15, P15
   Brooke G, 2007, SEMIN CELL DEV BIOL, V18, P846, DOI 10.1016/j.semcdb.2007.09.012
   Buxbaum Joseph D, 2009, Dialogues Clin Neurosci, V11, P35
   Callaway E., 2011, NATURE
   Carvalho MM, 2011, CURR STEM CELL RES T, V6, P221
   Chang YK, 2011, J BIOMED SCI, V18, DOI 10.1186/1423-0127-18-54
   Chen PM, 2011, J BIOMED SCI, V18, DOI 10.1186/1423-0127-18-49
   Courchesne E, 2001, NEUROLOGY, V57, P245
   Coury D, 2010, CURR OPIN NEUROL, V23, P131, DOI 10.1097/WCO.0b013e32833722fa
   Dazzi F, 2008, EUR J IMMUNOL, V38, P1479, DOI 10.1002/eji.200838433
   Dennis C., 2006, NATURE
   Dominici M, 2006, CYTOTHERAPY, V8, P315, DOI 10.1080/14653240600855905
   Drago D., 2013, BIOCHIMIE
   Enstrom AM, 2010, BRAIN BEHAV IMMUN, V24, P64, DOI 10.1016/j.bbi.2009.08.001
   Evans M, 2011, NAT REV MOL CELL BIO, V12, P680, DOI 10.1038/nrm3190
   Frenette PS, 2013, ANNU REV IMMUNOL, V31, P285, DOI 10.1146/annurev-immunol-032712-095919
   Galende E, 2010, CELL REPROGRAM, V12, P117, DOI 10.1089/cell.2009.0077
   Giuliani M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019988
   Goya RL, 2011, NEUROBIOL DIS, V41, P407, DOI 10.1016/j.nbd.2010.10.008
   Guillot PV, 2007, STEM CELLS, V25, P646, DOI 10.1634/stemcells.20060208
   Gupta S, 2010, J CLIN IMMUNOL, V30, pS90, DOI 10.1007/s10875-010-9402-9
   Hell RCR, 2009, NEUROBIOL DIS, V33, P290, DOI 10.1016/j.nbd.2008.10.017
   Hoogduijn MJ, 2010, INT IMMUNOPHARMACOL, V10, P1496, DOI 10.1016/j.intimp.2010.06.019
   Hsu YC, 2007, CELL TRANSPLANT, V16, P133
   Huang SS, 2011, CELL REPROGRAM, V13, P465, DOI 10.1089/cell.2011.0045
   Jackson SA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010706
   Klemmt PAB, 2011, EXPERT OPIN BIOL TH, V11, P1297, DOI 10.1517/14712598.2011.587800
   Ksizek K., 2009, REJUV RES, V12, P105
   Le Blanc K, 2005, CYTOTHERAPY, V7, P36, DOI 10.1080/14653240510018118
   Leeb C, 2011, CELL PROLIFERAT, V44, P9, DOI 10.1111/j.1365-2184.2010.00725.x
   Li Li, 2011, Front Med, V5, P33, DOI 10.1007/s11684-011-0114-1
   Locke M, 2011, STEM CELLS, V29, P404, DOI 10.1002/stem.593
   Lok C, 2012, NATURE, V481, P130, DOI 10.1038/481130a
   Majumdar MK, 1998, J CELL PHYSIOL, V176, P57, DOI 10.1002/(SICI)1097-4652(199807)176:1<57::AID-JCP7>3.0.CO;2-7
   Martino G, 2011, BRAIN, V134, P1585, DOI 10.1093/brain/awr115
   McCracken JT, 2005, J CLIN PSYCHIAT, V66, P32
   Meirelles LD, 2009, CYTOKINE GROWTH F R, V20, P419, DOI 10.1016/j.cytogfr.2009.10.002
   Meyerrose T, 2010, ADV DRUG DELIVER REV, V62, P1167, DOI 10.1016/j.addr.2010.09.013
   Ming X, 2008, J CHILD NEUROL, V23, P6, DOI 10.1177/0883073807307102
   Miyake K, 2012, ADV EXP MED BIOL, V724, P91, DOI 10.1007/978-1-4614-0653-2_7
   Nakamura Y, 2011, INT J HEMATOL, V93, P5, DOI 10.1007/s12185-010-0742-2
   Newman Robert E., 2009, Inflammation & Allergy Drug Targets, V8, P110
   Ng ES, 2005, BLOOD, V106, P1601, DOI 10.1182/blood-2005-03-0987
   Oblak AL, 2011, AUTISM RES, V4, P200, DOI 10.1002/aur.188
   Pan HC, 2009, J BIOMED SCI, V16, DOI 10.1186/1423-0127-16-75
   Pascucci L, 2011, VET IMMUNOL IMMUNOP, V144, P499, DOI 10.1016/j.vetimm.2011.07.017
   Pera MF, 2011, NATURE, V471, P46, DOI 10.1038/471046a
   Pera MF, 2000, J CELL SCI, V113, P5
   Piroth T., 2013, CELL TRANSPLANTATION
   Razavi S, 2013, DEV GROWTH DIFFER, V55, P648, DOI 10.1111/dgd.12072
   Sakuragawa N, 2001, JPN J PHARMACOL, V85, P20, DOI 10.1254/jjp.85.20
   Senju S, 2010, INT J HEMATOL, V91, P392, DOI 10.1007/s12185-010-0520-1
   Short B, 2003, ARCH MED RES, V34, P565, DOI 10.1016/j.arcmed.2003.09.007
   Siniscalco D, 2010, CELL MOL LIFE SCI, V67, P655, DOI 10.1007/s00018-009-0202-4
   Siniscalco D, 2012, STEM CELLS DEV, V21, P668, DOI 10.1089/scd.2011.0609
   Siniscalco D, 2012, J AUTISM DEV DISORD, V42, P1403, DOI 10.1007/s10803-011-1373-z
   Siniscalco D., 2013, J AUTISM DEV DISORDE
   Siniscalco Dario, 2011, Front Integr Neurosci, V5, P79, DOI 10.3389/fnint.2011.00079
   Siniscalco D, 2010, METHODS MOL BIOL, V617, P337, DOI 10.1007/978-1-60327-323-7_25
   Siniscalco Dario, 2008, Ther Adv Respir Dis, V2, P173, DOI 10.1177/1753465808092340
   Siniscalco D, 2013, MED HYPOTHESES, V81, P1, DOI 10.1016/j.mehy.2013.03.024
   Siniscalco D, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/480289
   Siniscalco Dario, 2012, J Cell Physiol, V227, P2283, DOI 10.1002/jcp.22945
   Siniscalco D., 2012, AUTISM, V2, P2
   Sotiropoulou Panagiota A., 2007, V407, P225, DOI 10.1007/978-1-59745-536-7_16
   Stevens H. E., 2010, FRONT NEUROSCI, V4, P59, DOI DOI 10.3389/FNINS.2010.00059
   Suzuki K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020470
   Tang Chad, 2013, Methods Mol Biol, V1029, P17, DOI 10.1007/978-1-62703-478-4_2
   Tatara R., 2011, CYTOTHERAPY, V13, P689
   Uchida S, 2000, J NEUROSCI RES, V62, P585, DOI 10.1002/1097-4547(20001115)62:4<585::AID-JNR13>3.0.CO;2-U
   Whitney ER, 2009, J NEUROSCI RES, V87, P2245, DOI 10.1002/jnr.22056
   Williams K, 2010, COCHRANE DB SYST REV, V8
   Witkowska-Zimny M, 2011, CELL MOL BIOL LETT, V16, P493, DOI 10.2478/s11658-011-0019-7
   Witkowska-Zimny M, 2011, CELL MOL BIOL LETT, V16, P236, DOI 10.2478/s11658-011-0005-0
   Yabut O, 2011, AGING-US, V3, P494
   Zemel'ko V I, 2013, Tsitologiia, V55, P101
   Zheng GP, 2013, WORLD J PEDIATR, V9, P197, DOI 10.1007/s12519-013-0425-1
   Zhou CH, 2011, CELL IMMUNOL, V272, P33, DOI 10.1016/j.cellimm.2011.09.010
NR 90
TC 1
Z9 1
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1687-966X
EI 1687-9678
J9 STEM CELLS INT
JI Stem Cells Int.
PY 2013
DI 10.1155/2013/262438
PG 7
WC Cell & Tissue Engineering
SC Cell Biology
GA 238HW
UT WOS:000325937200001
ER

PT J
AU Careaga, M
   Hansen, RL
   Hertz-Piccotto, I
   Van de Water, J
   Ashwood, P
AF Careaga, Milo
   Hansen, Robin L.
   Hertz-Piccotto, Irva
   Van de Water, Judy
   Ashwood, Paul
TI Increased Anti-Phospholipid Antibodies in Autism Spectrum Disorders
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID SYSTEMIC LUPUS-ERYTHEMATOSUS; ANTICARDIOLIPIN ANTIBODIES; IMMUNE
   DYSFUNCTION; INFECTIOUS ORIGIN; BRAIN-TISSUE; CHILDREN; AUTOANTIBODIES;
   BINDING; MYELIN; SERUM
AB Autism spectrum disorders (ASD) are characterized by impairments in communication, social interactions, and repetitive behaviors. While the etiology of ASD is complex and likely involves the interplay of genetic and environmental factors, growing evidence suggests that immune dysfunction and the presence of autoimmune responses including autoantibodies may play a role in ASD. Anti-phospholipid antibodies are believed to occur from both genetic and environmental factors and have been linked to a number of neuropsychiatric symptoms such as cognitive impairments, anxiety, and repetitive behaviors. In the current study, we investigated whether there were elevated levels of anti-phospholipid antibodies in a cross-sectional analysis of plasma of young children with ASD compared to age-matched typically developing (TD) controls and children with developmental delays (DD) other than ASD. We found that levels of anti-cardiolipin, beta 2-glycoprotein 1, and anti-phosphoserine antibodies were elevated in children with ASD compared with age-matched TD and DD controls. Further, the increase in antibody levels was associated with more impaired behaviors reported by parents. This study provides the first evidence for elevated production of anti-phospholipid antibodies in young children with ASD and provides a unique avenue for future research into determining possible pathogenic mechanisms that may underlie some cases of ASD.
C1 [Careaga, Milo; Ashwood, Paul] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95817 USA.
   [Careaga, Milo; Hansen, Robin L.; Hertz-Piccotto, Irva; Van de Water, Judy; Ashwood, Paul] Univ Calif Davis, MIND Inst, Davis, CA 95817 USA.
   [Hansen, Robin L.] Univ Calif Davis, Dept Pediat, Davis, CA 95817 USA.
   [Hertz-Piccotto, Irva] Univ Calif Davis, Div Epidemiol, Dept Publ Hlth Sci, Davis, CA 95817 USA.
   [Van de Water, Judy] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95817 USA.
RP Ashwood, P (reprint author), Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95817 USA.
EM pashwood@ucdavis.edu
CR American Psychiatric Association, 2000, TASK FORC D I DIAGN
   Andreoli L, 2012, ARTHRITIS RHEUM-US, V64, P342, DOI 10.1002/art.33341
   [Anonymous], 2008, MMWR-MORBID MORTAL W, V38, P1
   Ashwood P, 2008, J NEUROIMMUNOL, V204, P149, DOI 10.1016/j.jneuroim.2008.07.006
   Atladottir HO, 2012, PAEDIATR PERINAT EP, V26, P373, DOI 10.1111/j.1365-3016.2012.01296.x
   Avcin T, 2002, CLIN EXP RHEUMATOL, V20, P101
   Berkun Y, 2008, ISR MED ASSOC J, V10, P45
   Blank M, 2004, J CLIN IMMUNOL, V24, P12, DOI 10.1023/B:JOCI.0000018058.28764.ce
   Careaga M, 2010, NEUROTHERAPEUTICS, V7, P283, DOI 10.1016/j.nurt.2010.05.003
   Cervera R, 2002, ARTHRITIS RHEUM, V46, P1019, DOI 10.1002/art.10187
   Chapman J, 1999, LUPUS, V8, P127, DOI 10.1191/096120399678847524
   Enstrom A, 2009, BRAIN BEHAV IMMUN, V23, P389, DOI 10.1016/j.bbi.2008.12.005
   Enstrom AM, 2009, CURR OPIN INVEST DR, V10, P463
   Erkan Doruk, 2011, Pathophysiology, V18, P93, DOI 10.1016/j.pathophys.2010.04.010
   Goines P, 2011, BRAIN BEHAV IMMUN, V25, P514, DOI 10.1016/j.bbi.2010.11.017
   Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
   Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
   KHALILI A, 1991, CLIN EXP IMMUNOL, V85, P365
   KHAMASHTA MA, 1988, ANN RHEUM DIS, V47, P681, DOI 10.1136/ard.47.8.681
   Kirkman NJ, 2008, J AUTISM DEV DISORD, V38, P333, DOI 10.1007/s10803-007-0398-9
   Lavazza T, 2007, CLIN EXP RHEUMATOL, V25, P147
   Libbey JE, 2008, J AUTISM DEV DISORD, V38, P324, DOI 10.1007/s10803-007-0400-6
   LONG AA, 1991, THROMB HAEMOSTASIS, V66, P520
   Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661
   Menachem A, 2009, ANN NY ACAD SCI, V1173, P422, DOI 10.1111/j.1749-6632.2009.04876.x
   Miesbach W, 2006, CLIN NEUROL NEUROSUR, V108, P135, DOI 10.1016/j.clineuro.2005.03.005
   Mostafa GA, 2008, J CHILD NEUROL, V23, P1413, DOI 10.1177/0883073808319321
   Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
   Rosen NJ, 2007, PEDIATRICS, V119, pE61, DOI 10.1542/peds.2006-1788
   Rossi CC, 2011, BRAIN BEHAV IMMUN, V25, P1123, DOI 10.1016/j.bbi.2011.02.011
   Sanna G, 2003, RHEUMATOLOGY, V42, P200, DOI 10.1093/rheumatology/keg080
   Shoenfeld Y, 2006, ANN RHEUM DIS, V65, P2, DOI 10.1136/ard.2005.045443
   Shoenfeld Y, 2003, LUPUS, V12, P436, DOI 10.1191/0961203303lu409oa
   Shoenfeld Y, 1998, LUPUS, V7, pS158
   Singh VK, 2004, J BIOMED SCI, V11, P607, DOI 10.1159/000079672
   SINGH VK, 1993, BRAIN BEHAV IMMUN, V7, P97, DOI 10.1006/brbi.1993.1010
   Singh VK, 1997, PEDIATR NEUROL, V17, P88, DOI 10.1016/S0887-8994(97)00045-3
   Sokol DK, 2007, J NEUROIMMUNOL, V190, P151, DOI 10.1016/j.jneuroim.2007.08.002
   STEINHAUSEN HC, 1992, J CHILD PSYCHOL PSYC, V33, P731, DOI 10.1111/j.1469-7610.1992.tb00908.x
   SUN KH, 1992, ANN RHEUM DIS, V51, P707, DOI 10.1136/ard.51.6.707
   TODD RD, 1985, P NATL ACAD SCI USA, V82, P612, DOI 10.1073/pnas.82.2.612
   Wills S., 2011, MOL AUTISM, V2
   Wills S, 2009, BRAIN BEHAV IMMUN, V23, P64, DOI 10.1016/j.bbi.2008.07.007
   Wills S, 2007, ANN NY ACAD SCI, V1107, P79, DOI 10.1196/annals.1381.009
   Zambon M., 2012, HEMOCOAGULATIVE PROB, P209
   Zandman-Goddard G, 2007, SEMIN ARTHRITIS RHEU, V36, P297, DOI 10.1016/j.semarthrit.2006.11.003
   Ziporen L, 1997, J CLIN INVEST, V100, P613, DOI 10.1172/JCI119572
NR 47
TC 7
Z9 7
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 0962-9351
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
AR 935608
DI 10.1155/2013/935608
PG 7
WC Cell Biology; Immunology
SC Cell Biology; Immunology
GA 230GP
UT WOS:000325325400001
ER

PT J
AU Carminati, GG
   Lehotkay, R
   Martin, F
   Carminati, F
AF Carminati, Giuliana Galli
   Lehotkay, Rachel
   Martin, Franois
   Carminati, Federico
TI An Hypothesis about Jung's Collective Unconscious and Animal-assisted
   Therapy
SO NEUROQUANTOLOGY
LA English
DT Article
DE Jung's collective unconscious; Animal-assisted therapy; autism spectrum
   disorder; intellectual disability; behavioural disorders
ID QUANTUM-MECHANICS; ENVIRONMENTAL DECOHERENCE; FACILITATED THERAPY; MIND
   EFFORTS; CHILDREN; DEPRESSION; CONSCIOUSNESS; DISABILITIES; AUTISM; DOGS
AB Jung has described the collective unconscious as a layered structure starting from a central fire (Jung 1925), and composed by several groups (layers) of beings arriving progressively to the individual. In this schema Jung describes animal ancestors as one of the more ancient groups involved in human development. We relate this vision of the unconscious to our clinical experience with animal assisted therapy. Although properly speaking, animal-assisted therapy is not a new technique, we have adapted the approach to a specific context of intervention as a complement to conventional therapy, where the animal plays an intermediary role between therapist and patient. In case of patients presenting psychiatric disorders, animal-assisted therapy with a dog permitted a significant decrease in behavioural troubles with a real improvement of mood. Animal assisted therapy, used in the context of other therapeutic mediations, appears to have a significant impact in the population with severe autism spectrum disorders that cannot be easily treated verbally. In this study we explore the hypothesis that the improvement of the relationship with the others, obtained via the animal, can be related to a rewinding of the patient's unconscious to very primitive phases of his development. The patient relinks himself with a very ancient (temporally far and yet present) component of his unconscious. The present study offers elements of reflexion involving the therapeutic process in animal-assisted therapy and the Jungian theory of the collective unconscious.
C1 [Carminati, Giuliana Galli] Assoc TRAvail Groupal Therapeut & Social ASTRAG &, CH-1202 Geneva, Swityerland, Switzerland.
   [Lehotkay, Rachel] Univ Hosp Geneva, Dept Psychiat, Adult Psychiat Serv, Mental Dev Psychiat Unit, Geneva, Switzerland.
   [Martin, Franois] CNRS, F-75700 Paris, France.
   [Carminati, Federico] CERN, CH-1211 Geneva 23, Switzerland.
RP Carminati, GG (reprint author), Assoc TRAvail Groupal Therapeut & Social ASTRAG &, Rue Tronchin 4, CH-1202 Geneva, Swityerland, Switzerland.
EM giuliana.gallicarminati@hotmail.com; rachel.lehotkay@hcuge.ch;
   martin@lpthe.jussieu.fr; Federico.Carminati@cern.ch
CR Adler A., 1964, INDIVIDUAL PSYCHOL A
   Altmanspacher H., 2011, STANFORD ENCY PHILOS
   Altschuler E L, 1999, Ann Clin Psychiatry, V11, P29, DOI 10.3109/10401239909147045
   [Anonymous], 1987, ANTHROZOOS, V1, P41
   Antonioli C, 2005, BRIT MED J, V331, P1231, DOI 10.1136/bmj.331.7527.1231
   Aristotle, METAPHYSICS
   Athy AL, 2006, DISS ABSTR INT A, V66, P2498
   Baaquie BE, 2005, NEUROQUANTOLOGY, V3, P7
   Banks MR, 2005, ANTHROZOOS, V18, P396, DOI 10.2752/089279305785593983
   Barker SB, 1998, PSYCHIATR SERV, V49, P797
   Baudouin C, 1950, INSTINCT ESPRIT
   Baun MM, 2000, HDB ANIMAL ASSISTED, P237
   Beck F, 1998, B JAPANESE COGN SCI, V5, P95
   Bird A, 2007, NATURE, V447, P396, DOI 10.1038/nature05913
   Bouchard C, 1995, EFFECTS BENEFIQUES A
   BRICKEL C M, 1986, Clinical Gerontologist, V5, P309, DOI 10.1300/J018v05n03_06
   Carminati GG, 2007, RES AUTISM SPECT DIS, V1, P256, DOI 10.1016/j.rasd.2006.11.001
   Carminati GG, 2012, FRONT COLLECT, P289, DOI 10.1007/978-3-642-23157-5_11
   Corson S. A., 1980, ETHOLOGY NONVERBAL C, P83
   CORSON SA, 1977, COMPR PSYCHIAT, V18, P61, DOI 10.1016/S0010-440X(77)80008-4
   de Montaigne M., 1580, ESSAYS
   Descartes R., 1637, DISCOURS METHODE
   Drawe HL, 2001, DISS ABSTR INT B, V61, P6130
   Duncan SL, 2000, HDB ANIMAL ASSISTED, P303
   Eccles J.C., 1994, SELF CONTROLS ITS BR, P197
   Emerson RW, 1993, SELF RELIANCE
   Emerson RW, 1995, NATURE 1836 OXFORD C
   EVERETT H, 1957, REV MOD PHYS, V29, P454, DOI 10.1103/RevModPhys.29.454
   Ewing C. A., 2007, CHILD YOUTH CARE FOR, V36, P59, DOI [10.1007/s10566-006-9031-x, DOI 10.1007/S10566-006-9031-X]
   FOLSE EB, 1994, ANTHROZOOS, V7, P188
   FRIEDMANN E, 1983, J NERV MENT DIS, V171, P461, DOI 10.1097/00005053-198308000-00002
   FRIEDMANN E, 1980, PUBLIC HEALTH REP, V95, P307
   Carminati GG, 2004, EUR J PSYCHIAT, V18, P106
   Galli Carminati G., 1998, PSYCHOTHERAPIES, VXVIII
   Galli Carminati G, 2008, PHYS PART NUCLEI, V39, P560
   Galli Carminati G, 2008, REV MED SUISSE QUA S, V4, P542
   Galli Carminati G, 2007, ARCH SUISS NEUROL, V158, P233
   Georgiev D, 2012, NEUROQUANTOLOGY, V10, P374
   Heisenberg W, 1971, PHYSICS, P101
   Hogenson GB, 2001, J ANAL PSYCHOL, V46, P591, DOI 10.1111/1465-5922.00269
   Holcomb R, 1997, ANTHROZOOS, V10, P32
   JENKINS JL, 1986, PSYCHOL REP, V58, P21
   Jessen J, 1996, PSYCHOL REP, V78, P339
   Johnson Steven, 2001, EMERGENCE CONNECTED
   Jung C., 1959, ARCHETYPES COLLECTIV
   Jung C. G., 1960, STRUCTURE DYNAMICS P
   Jung Carl G., 1993, SYNCHRONICITY ACAUSA
   Jung CG, 1961, FREUD PSYCHOANALYSIS
   Jung CG, 1971, RACINES CONSCIENCE T, P167
   Jung CG, 1991, BOLLINGEN SERIES
   Jung CG, 1991, ANAL PSYCHOL
   Katcher A, 1998, ENVIRONMENT AND MENTAL HEALTH, P193
   Khrennikov A., 2002, CLASSICAL QUANTUM ME
   Kruger K. A., 2006, HDB ANIMAL ASSISTED, V2nd, P21
   La Mettrie J., 1747, HOMME MACHINE
   Lehotkay R., 2008, 1 C RES RET MENT RRM
   Lehotkay R., 2012, ETAPES SOINS GENEVE, P63
   Lehotkay R., 2009, THERAPIES EXTREME, P143
   Lehotkay R, 2009, C PET THER 2009 ZOOT
   Lehotkay R., 2009, ARCH SUISSE NEUROLOG, V160, P105
   Le Roux MC, 2009, PSYCHOGERIATRICS, V9, P23, DOI 10.1111/j.1479-8301.2009.00268.x
   LEVINSON BM, 1984, J CONTEMP PSYCHOTHER, V14, P131, DOI 10.1007/BF00946311
   Levinson B. M., 1969, PET ORIENTED CHILD P
   Limond JA, 1997, ANTHROZOOS, V10, P84
   Lockwood R., 1983, NEW PERSPECTIVES OUR, P64
   MADER B, 1989, CHILD DEV, V60, P1529, DOI 10.1111/j.1467-8624.1989.tb04023.x
   Mallon G. P., 1994, CHILD YOUTH CARE FOR, V23, P89, DOI 10.1007/BF02209256
   Martin F, 2009, J COSMOLOGY, V3, P580
   Martin F, 2002, WESTERN J NURS RES, V24, P657, DOI 10.1177/019394502236639
   Martin F, 2013, NEUROQUANTOLOGY, V11, P16
   McVarish CA, 1995, DISS ABSTR INT B, V55, P3019
   Meier CA, 2001, ATOM ARCHETYPE PAULI, P1580
   Menskii MB, 2000, USP FIZ NAUK+, V170, P631
   MENSKII MB, 2005, USP FIZ NAUK, V175, P413, DOI 10.3367/UFNr.0175.200504c.0413
   Mensky MB, 2007, OPT SPECTROSC+, V103, P461, DOI 10.1134/S0030400X07090159
   Mensky MB, 2007, NEUROQUANTOLOGY, V5, P363
   Mensky MB, 2005, HUMAN QUANTUM WORLD
   Messent P, 1983, NEW PERSPECTIVES OUR, P37
   Morgan TD, 2009, DISS ABSTR INT B, V69, P4435
   MUSCHEL IJ, 1984, SOC CASEWORK-JCSW, V65, P451
   Nielsen JA, 1989, ANTHROZOOS, V3, P119
   Nietzsche Friedrich, 1885, THUS SPOKE ZARATHUST
   ORLOV YF, 1982, INT J THEOR PHYS, V21, P37, DOI 10.1007/BF01880263
   Pavlides M., 2008, ANIMAL ASSISTED INTE
   Penrose R., 1994, SHADOWS MIND
   Penrose R., 1990, EMPERORS NEW MIND
   Prothmann A, 2009, ANTHROZOOS, V22, P161, DOI 10.2752/175303709X434185
   REDEFER LA, 1989, J AUTISM DEV DISORD, V19, P461, DOI 10.1007/BF02212943
   Sams MJ, 2006, AM J OCCUP THER, V60, P268
   Sato Y, 2003, SEISHIN IGAKU CLIN P, V45, P659
   Scholl S, 2008, THERAPEUTIC COMMUNIT, V29, P297
   Schopenhauer Arthur, 1966, WORLD WILL REPRESENT
   Schrodinger E, 1935, P CAMB PHILOS SOC, V31, P555
   Schwartz A, 2002, ANTHROZOOS, V15, P290
   Serpell J., 2000, HDB ANIMAL ASSISTED, P3
   Serpell J. A., 2004, CAN ANIMALS HELP HUM
   Seth AK, 2006, P NATL ACAD SCI USA, V103, P10799, DOI 10.1073/pnas.0604347103
   Sheldrake R, 2000, J SCI EXPLORATION, V14, P233
   Somervill JW, 2009, N AM J PSYCHOL, V11, P111
   Soutar-Freeman BM, 2003, DISS ABSTR INT B, V63, P5503
   Stapp H. P., 1993, MIND MATTER QUANTUM
   Stapp HP, 2001, FOUND PHYS, V31, P1465, DOI 10.1023/A:1012682413597
   Stapp HP, 2012, NEUROQUANTOLOGY, V10, P601
   Stevens A., 1996, EVOLUTIONARY PSYCHIA
   Stevens A., 1990, JUNG
   Stevens A, 1998, J ANAL PSYCHOL, V43, P345, DOI 10.1111/1465-5922.00033
   Taylor R. R., 2009, OCCUPATIONAL THERAPY, V25, P192, DOI 10.1150/01642120902859287
   Turner SF, 2003, DISS ABSTR INT B, V63, P3944
   Whiten A, 1999, NATURE, V399, P682, DOI 10.1038/21415
   World Health Organisation, 1994, ICD 10 INT STAT CLAS
   Zurek W. H., 2007, ARXIV07072832V1
   Zurek WH, 1998, ARXIVQUANTPH9805065
NR 112
TC 0
Z9 0
PU ANKA PUBLISHER
PI BORNOVA
PA 116-11 SOK NO.10 K 2 D 2, BORNOVA, IZMIR 35050, TURKEY
SN 1303-5150
J9 NEUROQUANTOLOGY
JI NeuroQuantology
PY 2013
VL 11
IS 3
BP 451
EP 465
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA 228QM
UT WOS:000325201400010
ER

PT J
AU Schipper, M
   Kullik, A
   Samson, AC
   Koglin, U
   Petermann, F
AF Schipper, Marc
   Kullik, Angelika
   Samson, Andrea C.
   Koglin, Ute
   Petermann, Franz
TI Emotion dysregulation in childhood
SO PSYCHOLOGISCHE RUNDSCHAU
LA German
DT Article
DE emotion dysregulation; internalizing and externalizing disorders; autism
   spectrum disorder (ASD); childhood
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; ANXIETY DISORDERS;
   ASPERGER-SYNDROME; INDIVIDUAL-DIFFERENCES; AGGRESSIVE-BEHAVIOR;
   MATERNAL-BEHAVIOR; MIDDLE CHILDHOOD; YOUNG-PEOPLE; CHILDREN
AB Emotion dysregulation is considered in the context of anxiety disorders and aggressive behavior in childhood; an additional focus lies on the role of emotion regulation in autism spectrum disorder. Several dysfunctional regulation strategies are identified. A brief overview on emotion dysregulation in child psychopathology is provided. Based on the reported findings the question whether and in how far dysfunctional regulation strategies can be viewed as a transdiagnostical factor is raised.
C1 [Schipper, Marc; Kullik, Angelika; Koglin, Ute; Petermann, Franz] Univ Bremen, Zentrum Klin Psychol & Rehabil, D-28359 Bremen, Germany.
   [Samson, Andrea C.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
RP Schipper, M (reprint author), Univ Bremen, Zentrum Klin Psychol & Rehabil, Grazer Str 2 U 6, D-28359 Bremen, Germany.
EM marc.schipper@uni-bremen.de
CR Aldao A, 2010, CLIN PSYCHOL REV, V30, P217, DOI 10.1016/j.cpr.2009.11.004
   Aldao A., 2010, J ABNORM PSYCHOL, V121, P276
   Bar-Haim Y, 2011, EMOTION, V11, P215, DOI 10.1037/a0022602
   Barnow S, 2012, PSYCHOL RUNDSCH, V63, P111, DOI 10.1026/0033-3042/a000119
   Blandon AY, 2008, DEV PSYCHOL, V44, P1110, DOI 10.1037/0012-1649.44.4.1110
   Blandon AY, 2010, DEV PSYCHOPATHOL, V22, P119, DOI 10.1017/S0954579409990307
   Bower JE, 2005, ANN BEHAV MED, V29, P236, DOI 10.1207/s15324796abm2903_10
   Calkins SD, 1999, SOC DEV, V8, P310, DOI 10.1111/1467-9507.00098
   Carthy T, 2010, BEHAV RES THER, V48, P384, DOI 10.1016/j.brat.2009.12.013
   Casey RJ, 1996, EMOTIONAL DEVELOPMENT IN ATYPICAL CHILDREN, P161
   Cisler JM, 2010, J PSYCHOPATHOL BEHAV, V32, P68, DOI 10.1007/s10862-009-9161-1
   CRICK NR, 1994, PSYCHOL BULL, V115, P74, DOI 10.1037/0033-2909.115.1.74
   Crockenberg SC, 2008, DEV PSYCHOPATHOL, V20, P37, DOI 10.1017/S0954579408000023
   Dorn C, 2013, PSYCHOL RUNDSCH, V64, P217, DOI 10.1026/0033-3042/a000176
   Eisenberg N, 2001, CHILD DEV, V72, P1112, DOI 10.1111/1467-8624.00337
   Feng X, 2008, J CHILD PSYCHOL PSYC, V49, P132, DOI 10.1111/j.1469-7610.2007.01828.x
   FERGUSSON DM, 1993, PEDIATRICS, V92, P815
   Garnefski N, 2002, J ADOLESCENCE, V25, P603, DOI 10.1006/jado.0507
   Gross JJ, 2003, J PERS SOC PSYCHOL, V85, P348, DOI 10.1037/0022-3514.85.2.348
   Gross JJ, 2002, PSYCHOPHYSIOLOGY, V39, P281, DOI 10.1017/S0048577201393198
   Halligan SL, 2013, DEV PSYCHOPATHOL, V25, P391, DOI 10.1017/S0954579412001137
   Hannesdottir DK, 2010, DEV PSYCHOBIOL, V52, P197, DOI 10.1002/dev.20425
   Helmsen J, 2012, CHILD PSYCHIAT HUM D, V43, P87, DOI 10.1007/s10578-011-0252-3
   Hill AL, 2006, DEV PSYCHOL, V42, P913, DOI 10.1037/0012-1649.42.5.913
   Hudson JL, 2011, J AM ACAD CHILD PSY, V50, P1255, DOI 10.1016/j.jaac.2011.09.009
   Jahromi LB, 2012, J CHILD PSYCHOL PSYC, V53, P1250, DOI 10.1111/j.1469-7610.2012.02560.x
   Jahromi LB, 2013, RES AUTISM SPECT DIS, V7, P235, DOI 10.1016/j.rasd.2012.08.012
   Kim J, 2010, J CHILD PSYCHOL PSYC, V51, P706, DOI 10.1111/j.1469-7610.2009.02202.x
   Kim-Spoon J, 2013, CHILD DEV, V84, P512, DOI 10.1111/j.1467-8624.2012.01857.x
   Koglin U, 2008, Z PSYCHIATR PSYCH PS, V56, P133, DOI 10.1024/1661-4747.56.2.133
   Konstantareas MM, 2006, J AUTISM DEV DISORD, V36, P143, DOI 10.1007/s10803-005-0051-4
   Kullik A., 2012, EMOTIONSREGULATION K
   Kullik A, 2012, Z PSYCHIATR PSYCH PS, V60, P165, DOI 10.1024/1661-4747/a000113
   Kullik A, 2013, FORTSCHR NEUROL PSYC, V81, P35, DOI 10.1055/s-0032-1330320
   Laurent AC, 2004, TOP LANG DISORD, V24, P286
   Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x
   Lewis MD, 2006, ANN NY ACAD SCI, V1094, P164, DOI 10.1196/annals.1376.017
   Losh M, 2006, DEV PSYCHOL, V42, P809, DOI 10.1037/0012-1649.42.5.809
   Marsee MA, 2007, J ABNORM CHILD PSYCH, V35, P969, DOI 10.1007/s10802-007-9147-y
   Mazefsky CA, 2012, CHILD DEV PERSPECT, V6, P92, DOI 10.1111/j.1750-8606.2011.00229.x
   Otterpohl N, 2012, KINDH ENTWICKL, V21, P47, DOI 10.1026/0942-5403/a000069
   Petermann F, 2011, KINDH ENTWICKL, V20, P186, DOI 10.1026/0942-5403/a000055
   Petermann F, 2002, Z KLIN PSYCH PSYCHIA, V50, P1
   Petermann F, 2012, KINDH ENTWICKL, V21, P77, DOI 10.1026/0942-5403/a000073
   Poustka L, 2012, KINDH ENTWICKL, V21, P81, DOI 10.1026/0942-5403/a000074
   Prizant B. M., 2011, AUTISM SPECTRUM Q, V1, P29
   Quek LH, 2012, J CLIN PSYCHOL, V68, P1142, DOI 10.1002/jclp.21888
   Rieffe C, 2011, AUTISM, V15, P655, DOI 10.1177/1362361310366571
   Roll J, 2012, CHILD PSYCHIAT HUM D, V43, P909, DOI 10.1007/s10578-012-0303-4
   Samson AC, 2012, EMOTION, V12, P659, DOI 10.1037/a0027975
   Scarpa A, 2011, BEHAV COGN PSYCHOTH, V39, P495, DOI 10.1017/S1352465811000063
   Schipper M, 2013, SOC NEUROSCI-UK, V8, P101, DOI 10.1080/17470919.2012.761650
   Schmidt MH, 2012, KINDH ENTWICKL, V21, P245, DOI 10.1026/0942-5403/a000091
   Schwenck C, 2012, J CHILD PSYCHOL PSYC, V53, P651, DOI 10.1111/j.1469-7610.2011.02499.x
   Shafir D., 2008, HDB DEPRESSION CHILD, P149
   Sofronoff K, 2007, J AUTISM DEV DISORD, V37, P1203, DOI 10.1007/s10803-006-0262-3
   Suveg C, 2011, CHILD PSYCHIAT HUM D, V42, P507, DOI 10.1007/s10578-011-0223-8
   Suveg C, 2004, J CLIN CHILD ADOLESC, V33, P750, DOI 10.1207/s15374424jccp3304_10
   Thompson R., 2007, HDB EMOTION REGULATI, V50, P3, DOI DOI 10.1080/00140130600971135
   Thompson R A, 1994, Monogr Soc Res Child Dev, V59, P25, DOI 10.2307/1166137
   Klin A, 2003, CHILD ADOL PSYCH CL, V12, P1, DOI 10.1016/S1056-4993(02)00052-4
   Wahlstedt C, 2008, DEV NEUROPSYCHOL, V33, P160, DOI 10.1080/87565640701884253
   Wiedebusch S, 2011, KINDH ENTWICKL, V20, P209, DOI 10.1026/0942-5403/a000058
   Witthoft J, 2011, Z PSYCHIATR PSYCH PS, V59, P11, DOI 10.1024/1661-4747/a000048
   Zimmermann LK, 2003, J GENET PSYCHOL, V164, P389
NR 65
TC 1
Z9 1
PU HOGREFE & HUBER PUBLISHERS
PI GOTTINGEN
PA ROHNSWEG 25, D-37085 GOTTINGEN, GERMANY
SN 0033-3042
J9 PSYCHOL RUNDSCH
JI Psychol. Rundsch.
PY 2013
VL 64
IS 4
BP 228
EP 234
DI 10.1026/0033-3042/a000175
PG 7
WC Psychology, Multidisciplinary
SC Psychology
GA 226AO
UT WOS:000325006800005
ER

PT J
AU Rutter, P
   Taylor, D
   Branford, D
AF Rutter, Paul
   Taylor, Denise
   Branford, Dave
TI Mental Health Curricula at Schools of Pharmacy in the United Kingdom and
   Recent Graduates' Readiness to Practice
SO AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
LA English
DT Article
DE mental health; pharmacy education; graduate; curriculum
ID RISK-FACTORS; SCHIZOPHRENIA; DISORDERS; STUDENTS; NONADHERENCE;
   MEDICATION; ATTITUDES; PEOPLE; BURDEN
AB Objective. To assess mental health education in the undergraduate pharmacy curricula in the United Kingdom and gauge how well prepared graduates are to manage mental health patients.
   Method. The authors conducted semi-structured telephone interviews with pharmacy educators and administered an electronic self-administered survey instrument to pharmacy graduates.
   Results. The mental health conditions of depression, schizophrenia, bipolar disorder, and Parkinson disease were taught, in detail, by all schools, but more specialized areas of mental health (eg, personality disorder, autism) were generally not taught. Just 5 of 19 schools attempted to teach the broader social aspects of mental health. A third of the schools provided experiential learning opportunities. Graduates and recently registered pharmacists stated that undergraduate education had prepared them adequately with regard to knowledge on conditions and treatment options, but that they were not as well prepared to talk with mental health patients and deal with practical drug management-related issues.
   Conclusion. The mental health portion of the undergraduate pharmacy curricula in colleges and schools of pharmacy in the United Kingdom is largely theoretical, and pharmacy students have little exposure to mental health patients. Graduates identified an inability to effectively communicate with these patients and manage common drug management-related issues.
C1 [Rutter, Paul] Wolverhampton Univ, Wolverhampton WV1 1SB, England.
   [Taylor, Denise] Coll Mental Hlth Pharm, Oxford, England.
   [Branford, Dave] Derbyshire Healthcare Natl Hlth Serv Fdn Trust, Derby, England.
RP Rutter, P (reprint author), Wolverhampton Univ, Dept Pharm, Wulfruna St, Wolverhampton WV1 1SB, England.
EM paul.rutter@wlv.ac.uk
FU College of Mental Health Pharmacy
FX This work was supported by a grant from The College of Mental Health
   Pharmacy.
CR [Anonymous], 2012, BMC MED EDUC, V12, P120
   Ascher-Svanum H, 2006, J CLIN PSYCHIAT, V67, P1114
   Bell JS, 2008, PHARM WORLD SCI, V30, P595, DOI 10.1007/s11096-008-9211-x
   Bell JS, 2006, AM J PHARM EDUC, V70
   Brandford D, 1990, PHARM J, V245, P591
   Cates ME, 2007, AM J PHARM EDUC, V71
   Couture S., 2003, J MENTAL HLTH, V12, P291, DOI DOI 10.1080/09638231000118276
   Department of Health, NAT SERV FRAM MENT H
   Department of Health, NO HLTH MENT HLTH CR
   Dipaula BA, 2011, AM J PHARM EDUC, V75
   Druss BG, 2009, MOL PSYCHIATR, V14, P728, DOI 10.1038/mp.2008.13
   Greenberg PE, 1999, J CLIN PSYCHIAT, V60, P427
   Lacro JP, 2002, J CLIN PSYCHIAT, V63, P892
   National Institute of Mental Health, MENT HLTH MED
   Patten SB, 2012, BMC MED EDUC, V12, DOI 10.1186/1472-6920-12-120
   Royal Pharmaceutical Society of Great Britain, PHARM WORKF CENS 200
   Wittchen HU, 2011, EUR NEUROPSYCHOPHARM, V21, P655, DOI 10.1016/j.euroneuro.2011.07.018
NR 17
TC 0
Z9 0
PU AMER ASSOC COLL PHARMACY
PI ALEXANDRIA
PA 1426 PRINCE STREET, ALEXANDRIA, VA 22314-2815 USA
SN 0002-9459
J9 AM J PHARM EDUC
JI Am. J. Pharm. Educ.
PY 2013
VL 77
IS 7
AR 147
PG 7
WC Education, Scientific Disciplines; Pharmacology & Pharmacy
SC Education & Educational Research; Pharmacology & Pharmacy
GA 217RZ
UT WOS:000324379300012
PM 24052650
ER

PT J
AU Giulivi, C
   Napoli, E
   Schwartzer, J
   Careaga, M
   Ashwood, P
AF Giulivi, Cecilia
   Napoli, Eleonora
   Schwartzer, Jared
   Careaga, Milo
   Ashwood, Paul
TI Gestational Exposure to a Viral Mimetic Poly(I:C) Results in
   Long-Lasting Changes in Mitochondrial Function by Leucocytes in the
   Adult Offspring
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; PREECLAMPSIA-LIKE SYMPTOMS; PRONE BB RAT;
   PRENATAL INFECTION; MATERNAL INFECTION; BRAIN-DEVELOPMENT;
   GENE-EXPRESSION; INNATE IMMUNITY; OXIDATIVE-PHOSPHORYLATION;
   ELECTRON-TRANSPORT
AB Maternal immune activation (MIA) is a potential risk factor for autism spectrum disorder ( ASD) and schizophrenia ( SZ). In rodents, MIA results in changes in cytokine profiles and abnormal behaviors in the offspring that model these neuropsychiatric conditions. Given the central role that mitochondria have in immunity and other metabolic pathways, we hypothesized that MIA will result in a fetal imprinting that leads to postnatal deficits in the bioenergetics of immune cells. To this end, splenocytes from adult offspring exposed gestationally to the viral mimic poly(I: C) were evaluated for mitochondrial outcomes. Asignificant decrease in mitochondrial ATP production was observed in poly( I: C)-treated mice (45% of controls) mainly attributed to a lower complex I activity. No differences were observed between the two groups in the coupling of electron transport to ATP synthesis, or the oxygen uptake under uncoupling conditions. Concanavalin A-(ConA-) stimulated splenocytes from poly(I: C) animals showed no statistically significant changes in cytokine levels compared to controls. The present study reports for the first time that MIA activation by poly(I: C) at early gestation, which can lead to behavioral impairments in the offspring similar to SZ and ASD, leads to long-lasting effects in the bioenergetics of splenocytes of adult offspring.
C1 [Giulivi, Cecilia; Napoli, Eleonora] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA.
   [Giulivi, Cecilia; Schwartzer, Jared; Careaga, Milo; Ashwood, Paul] Univ Calif Davis, Med Invest Neurodev Disorders MIND Inst, Davis, CA 95616 USA.
   [Careaga, Milo; Ashwood, Paul] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA.
RP Giulivi, C (reprint author), Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA.
EM cgiulivi@ucdavis.edu
FU fromthe Simons Foundation [271406]; NIEHS [R01ES011269, R01-ES015359,
   R01-ES020392]; Autism Speaks Foundation; NARSAD Foundation; Jane
   Botsford Johnson Foundation; Peter Emch Foundation
FX This study was performed under the funding fromthe Simons Foundation
   (no. 271406 to Cecilia Giulivi), NIEHS R01ES011269, R01-ES015359, and
   R01-ES020392, Autism Speaks Foundation, NARSAD Foundation, Jane Botsford
   Johnson Foundation, and Peter Emch Foundation. The abovementioned
   funding agencies were not responsible for the design and conduct of the
   study; collection, management, analysis, and interpretation of the data;
   and preparation, review, or approval of this paper. The authors of this
   publication declare that they have no conflicting financial interest in
   relation to the work described. Cecilia Giulivi, designed this study
   andwrote the paper; EleonoraNapoli performed all work related to
   mitochondrial outcomes, contributed to the writing of the paper, and
   analyzed the data; Jared Schwartzer and Milo Careaga performed the
   animal exposures, immune response, collected the cells utilized in this
   study, and reviewed the paper; Paul Ashwood designed the treatment of
   animals and contributed to the writing of the paper.
CR Abrahams VM, 2004, J IMMUNOL, V173, P4286
   Arnoult D, 2011, EMBO REP, V12, P901, DOI 10.1038/embor.2011.157
   Arrode-Bruses G., 2012, J NEUROINFLAMMATION, V9
   Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
   Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
   Bauerfeld CP, 2012, J IMMUNOL, V188, P2847, DOI 10.4049/jimmunol.1102157
   Brown AS, 2011, SCHIZOPHRENIA BULL, V37, P284, DOI 10.1093/schbul/sbq146
   Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
   Brown AS, 2004, ARCH GEN PSYCHIAT, V61, P774, DOI 10.1001/archpsyc.61.8.774
   Brown AS, 2004, AM J PSYCHIAT, V161, P889, DOI 10.1176/appi.ajp.161.5.889
   Burgueno AL, 2013, J NUTR BIOCHEM, V24, P6, DOI 10.1016/j.jnutbio.2011.12.008
   Burlak C, 2006, MOL CELL PROTEOMICS, V5, P620, DOI 10.1074/mcp.M500336-MCP200
   Burton A, 2012, J REPROD IMMUNOL, V93, P9, DOI 10.1016/j.jri.2011.11.005
   Calder PC, 1999, AMINO ACIDS, V17, P227, DOI 10.1007/BF01366922
   Carta S, 2012, ANN RHEUM DIS, V71, P1577, DOI 10.1136/annrheumdis-2012-201340
   Chatterjee P, 2011, HYPERTENSION, V58, P489, DOI 10.1161/HYPERTENSIONAHA.111.172114
   Chauhan A, 2011, J NEUROCHEM, V117, P209, DOI 10.1111/j.1471-4159.2011.07189.x
   Chugani DC, 1999, PROG NEURO-PSYCHOPH, V23, P635, DOI 10.1016/S0278-5846(99)00022-6
   Cipolla MJ, 2011, REPROD SCI, V18, P1211, DOI 10.1177/1933719111410712
   Clancy B, 2007, NEUROTOXICOLOGY, V28, P931, DOI 10.1016/j.neuro.2007.01.014
   Cloonan SM, 2012, CURR OPIN IMMUNOL, V24, P32, DOI 10.1016/j.coi.2011.11.001
   Curi R, 1999, BRAZ J MED BIOL RES, V32, P15
   Deverman BE, 2009, NEURON, V64, P61, DOI 10.1016/j.neuron.2009.09.002
   ERNSTER L, 1981, J CELL BIOL, V91, P227, DOI DOI 10.1083/JCB.91.3.227S
   EWEL CH, 1992, DIABETES, V41, P1016, DOI 10.2337/diabetes.41.8.1016
   Farina GA, 2010, J INVEST DERMATOL, V130, P2583, DOI 10.1038/jid.2010.200
   Fortier ME, 2007, BEHAV BRAIN RES, V181, P270, DOI 10.1016/j.bbr.2007.04.016
   Fossati G, 2003, J IMMUNOL, V170, P1964
   Fukatsu K, 2001, SHOCK, V15, P318, DOI 10.1097/00024382-200115040-00012
   Garay P. A, 2010, FRONTIERS SYNAPTIC N, V2
   Garay PA, 2013, BRAIN BEHAV IMMUN, V31, P54, DOI 10.1016/j.bbi.2012.07.008
   Garcia AP, 2013, PEPTIDES, V39, P59, DOI 10.1016/j.peptides.2012.11.005
   Genestier AL, 2005, J CLIN INVEST, V115, P3117, DOI 10.1172/JCI22684
   Gilmore JH, 2004, NEUROPSYCHOPHARMACOL, V29, P1221, DOI 10.1038/sj.npp.1300446
   Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
   Gregg JP, 2008, GENOMICS, V91, P22, DOI 10.1016/j.ygeno.2007.09.003
   Guleria I, 2000, NAT MED, V6, P589
   Hamlyn J, 2013, NEUROBIOL DIS, V53, P3, DOI 10.1016/j.nbd.2012.10.023
   HATEFI Y, 1985, ANNU REV BIOCHEM, V54, P1015, DOI 10.1146/annurev.biochem.54.1.1015
   Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15
   Hwang HS, 2008, CIRCULATION, V118, pS288
   Jewell CM, 2011, P NATL ACAD SCI USA, V108, P15745, DOI 10.1073/pnas.1105200108
   Koga K, 2009, AM J REPROD IMMUNOL, V61, P196, DOI 10.1111/j.1600-0897.2008.00682.x
   Liu TF, 2012, J LEUKOCYTE BIOL, V92, P499, DOI 10.1189/jlb.0212078
   Lombard J, 1998, MED HYPOTHESES, V50, P497, DOI 10.1016/S0306-9877(98)90270-5
   Maianski NA, 2004, CELL DEATH DIFFER, V11, P143, DOI 10.1038/sj.cdd.4401320
   Malanski N. A, 2003, BLOOD, V101, P1987
   Mandal M, 2011, BRAIN BEHAV IMMUN, V25, P863, DOI 10.1016/j.bbi.2010.09.011
   Meyer U, 2005, NEUROSCI BIOBEHAV R, V29, P913, DOI 10.1016/j.neubiorev.2004.10.012
   Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
   MINSHEW NJ, 1993, BIOL PSYCHIAT, V33, P762, DOI 10.1016/0006-3223(93)90017-8
   Mor G, 2005, CRIT REV IMMUNOL, V25, P375, DOI 10.1615/CritRevImmunol.v25.i5.30
   Napoli E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042504
   Napoli E., 2013, MOL AUTISM, V4
   Napoli E, 2013, TOXICOL SCI, V132, P196, DOI 10.1093/toxsci/kfs339
   Newsholme P, 2001, J NUTR S, V131
   Oka T, 2012, NATURE, V485, P251, DOI 10.1038/nature10992
   Oliveira G, 2005, DEV MED CHILD NEUROL, V47, P185, DOI 10.1017/S0012162205000332
   Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
   Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
   Patterson PH, 2012, BRAIN BEHAV IMMUN, V26, P393, DOI 10.1016/j.bbi.2011.09.008
   Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
   Patterson PH, 2011, PEDIAT RES 2, V69, P34, DOI 10.1203/PDR.0b013e318212b80f
   Piantadosi CA, 2012, BBA-GEN SUBJECTS, V1820, P532, DOI 10.1016/j.bbagen.2012.01.003
   Pineda A, 2011, ARCH MED RES, V42, P382, DOI 10.1016/j.arcmed.2011.08.003
   Pithon-Curi T. C, 1997, AM J PHYSIOL, V273, pC1124
   Pithon-Curi TC, 2002, CLIN SCI, V103, P403
   RUSTIN P, 1994, CLIN CHIM ACTA, V228, P35, DOI 10.1016/0009-8981(94)90055-8
   Sasai M, 2006, J IMMUNOL, V177, P8676
   Scheel-Toellner D, 2004, BLOOD, V104, P2557, DOI 10.1182/blood-2004-01-0191
   Schwartzer J. J, 2013, TRANSLATIONAL PSYCHI, V3
   SERREZE DV, 1989, J AUTOIMMUN, V2, P759, DOI 10.1016/0896-8411(89)90003-6
   Seth RB, 2006, CELL RES, V16, P141, DOI 10.1038/sj.cr.7310019
   Shi HX, 2011, PLOS PATHOG, V7, DOI 10.1371/journal.ppat.1002057
   Smith SEP, 2007, J NEUROSCI, V27, P10695, DOI 10.1523/JNEUROSCI.2178-07.2007
   Sobel DO, 1998, J AUTOIMMUN, V11, P343, DOI 10.1006/jaut.1998.0203
   SOBEL DO, 1992, DIABETES, V41, P515, DOI 10.2337/diabetes.41.4.515
   Subramanian N, 2013, CELL, V153, P348, DOI 10.1016/j.cell.2013.02.054
   Suliman HB, 2005, FASEB J, V19, P1531, DOI 10.1096/fj.04-3500fje
   Sweeney T. E., 2010, PLOS ONE, V5
   Sweeney TE, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025249
   THOMAS VA, 1991, DIABETES, V40, P255, DOI 10.2337/diabetes.40.2.255
   Tinsley JH, 2009, AM J HYPERTENS, V22, P1314, DOI 10.1038/ajh.2009.185
   Walker CK, 2013, BIOL PSYCHIAT, V74, P204, DOI 10.1016/j.biopsych.2013.03.006
   West AP, 2011, NAT REV IMMUNOL, V11, P389, DOI 10.1038/nri2975
   Wills S, 2007, ANN NY ACAD SCI, V1107, P79, DOI 10.1196/annals.1381.009
   Yassad A, 2000, CYTOKINE, V12, P1288, DOI 10.1006/cyto.1999.0729
NR 87
TC 3
Z9 3
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 0962-9351
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
AR 609602
DI 10.1155/2013/609602
PG 8
WC Cell Biology; Immunology
SC Cell Biology; Immunology
GA 225IH
UT WOS:000324955200001
ER

PT J
AU Williams, K
   Brignell, A
   Randall, M
   Silove, N
   Hazell, P
AF Williams, Katrina
   Brignell, Amanda
   Randall, Melinda
   Silove, Natalie
   Hazell, Philip
TI Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum
   disorders (ASD)
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Age Factors; Autistic Disorder [drug therapy; psychology]; Citalopram
   [therapeutic use]; Fenfluramine [therapeutic use]; Fluoxetine
   [therapeutic use]; Fluvoxamine [therapeutic use]; Obsessive-Compulsive
   Disorder [drug therapy]; Randomized Controlled Trials as Topic;
   Serotonin Uptake Inhibitors [therapeutic use]; Adult; Child; Humans
ID OBSESSIVE-COMPULSIVE SCALE; PERVASIVE DEVELOPMENTAL DISORDERS;
   DOUBLE-BLIND; REPETITIVE BEHAVIORS; MEDICATION USE; CHILDREN; PLACEBO;
   FLUOXETINE; CLOMIPRAMINE; CHILDHOOD
AB Background
   Autism spectrum disorders (ASD) are characterised by abnormalities in social interaction and communication skills, as well as stereotypic behaviours and restricted activities and interests. Selective serotonin reuptake inhibitors (SSRIs) are prescribed for the treatment of conditions often comorbid with ASD such as depression, anxiety and obsessive-compulsive behaviours.
   Objectives
   To determine if treatment with an SSRI:
   1. improves the core features of autism (social interaction, communication and behavioural problems);
   2. improves other non-core aspects of behaviour or function such as self-injurious behaviour;
   3. improves the quality of life of adults or children and their carers;
   4. has short-and long-term effects on outcome;
   5. causes harm.
   Search methods
   We searched the following databases up until March 2013: CENTRAL, Ovid MEDLINE, Embase, CINAHL, PsycINFO, ERIC and Sociological Abstracts. We also searched ClinicalTrials.gov and the International Clinical Trials Registry Platform (ICTRP). This was supplemented by searching reference lists and contacting known experts in the field.
   Selection criteria
   Randomised controlled trials (RCTs) of any dose of oral SSRI compared with placebo, in people with ASD.
   Data collection and analysis
   Two authors independently selected studies for inclusion, extracted data and appraised each study's risk of bias.
   Main results
   Nine RCTs with a total of 320 participants were included. Four SSRIs were evaluated: fluoxetine (three studies), fluvoxamine (two studies), fenfluramine (two studies) and citalopram (two studies). Five studies included only children and four studies included only adults. Varying inclusion criteria were used with regard to diagnostic criteria and intelligence quotient of participants. Eighteen different outcome measures were reported. Although more than one study reported data for Clinical Global Impression (CGI) and obsessive-compulsive behaviour (OCB), different tool types or components of these outcomes were used in each study. As such, data were unsuitable for meta-analysis, except for one outcome (proportion improvement). One large, high-quality study in children showed no evidence of positive effect of citalopram. Three small studies in adults showed positive outcomes for CGI and OCB; one study showed improvements in aggression, and another in anxiety.
   Authors' conclusions
   There is no evidence of effect of SSRIs in children and emerging evidence of harm. There is limited evidence of the effectiveness of SSRIs in adults from small studies in which risk of bias is unclear.
C1 [Williams, Katrina; Brignell, Amanda; Randall, Melinda] Univ Melbourne, Dept Paediat, Royal Childrens Hosp, Parkville, Vic 3052, Australia.
   [Williams, Katrina] Royal Childrens Hosp, Clin Off 3W, Parkville, Vic 3052, Australia.
   [Williams, Katrina] Murdoch Childrens Res Inst, Parkville, Vic, Australia.
   [Silove, Natalie] Childrens Hosp Westmead, Child Dev Unit, Westmead, NSW, Australia.
   [Hazell, Philip] Sydney Med Sch, Discipline Psychiat, Concord West, Australia.
RP Williams, K (reprint author), Univ Melbourne, Dept Paediat, Royal Childrens Hosp, Parkville, Vic 3052, Australia.
EM katrina.williams@rch.org.au
RI Williams, Katrina/B-6828-2015
OI Williams, Katrina/0000-0002-1686-4458
FU Small Grants Scheme, The Children's Hospital at Westmead, Sydney,
   Australia; Financial Markets Foundation for Children, Australia;
   Department of Health and Aging, Australia; Cochrane Entities
FX Internal sourcesSmall Grants Scheme, The Children's Hospital at
   Westmead, Sydney, Australia.External sourcesFinancial Markets Foundation
   for Children, Australia.Department of Health and Aging,
   Australia.Cochrane Entities funding
CR Aman MG, 2005, J CHILD ADOL PSYCHOP, V15, P116, DOI 10.1089/cap.2005.15.116
   American Psychiatric Association, 1987, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT
   American Psychiatric Association, 1980, DIAGN STAT MAN MENT
   BARTHELEMY C, 1989, J AUTISM DEV DISORD, V19, P241, DOI 10.1007/BF02211844
   Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
   Bodfish J.W., 1999, REPETITIVE BEHAV SCA
   Branford D, 1998, J INTELL DISABIL RES, V42, P301, DOI 10.1046/j.1365-2788.1998.00144.x
   Buchsbaum MS, 2001, INT J NEUROPSYCHOPH, V4, P119
   Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008
   Doyle J J, 2001, Value Health, V4, P16, DOI 10.1046/j.1524-4733.2001.004001016.x
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1012
   GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
   GORDON CT, 1993, ARCH GEN PSYCHIAT, V50, P441
   Greenhill LL, 2004, J AM ACAD CHILD PSY, V43, P1488, DOI 10.1097/01.chi.0000142668.29191.13
   Gringras P, 2000, AUTISM, V4, P229, DOI 10.1177/1362361300004003002
   Guy W., 1976, ECDEU ASSESSMENT MAN
   Higgins JPT, 2002, STAT MED, V21, P1539, DOI 10.1002/sim.1186
   Higgins JPT, 2011, COCHRANE HDB SYSTEMA
   Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627
   Hollander E, 2012, AM J PSYCHIAT, V169, P292, DOI 10.1176/appi.ajp.2011.10050764
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Humble M, 2001, BIOL PSYCHIAT, V49, P360, DOI 10.1016/S0006-3223(00)00956-2
   Hurwitz R, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008372.pub2
   Jesner OS, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005040.pub2
   King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30
   King BH, 2006, CHILD ADOL PSYCH CL, V15, P161, DOI 10.1016/j.chc.2005.08.005
   Lefebvre C, 2011, COCHRANE HDB SYSTEMA
   LEVENTHAL BL, 1993, J NEUROPSYCH CLIN N, V5, P307
   Mandell DS, 2008, PEDIATRICS, V121, pE441, DOI 10.1542/peds.2007-0984
   McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P1001
   McDougle CJ, 1998, J CLIN PSYCHOPHARM, V18, P62, DOI 10.1097/00004714-199802000-00010
   McKay D, 2003, PSYCHOL ASSESSMENT, V15, P578, DOI 10.1037/1040-3590.15.4.578
   Murray ML, 2005, BRIT MED J, V330, P1151, DOI 10.1136/bmj.330.7500.1151
   Nemeroff CB, 2007, ARCH GEN PSYCHIAT, V64, P466, DOI 10.1001/archpsyc.64.4.466
   Oswald DP, 2007, J CHILD ADOL PSYCHOP, V17, P348, DOI 10.1089/cap.2006.17303
   Peral M, 1999, J AM ACAD CHILD PSY, V38, P1472, DOI 10.1097/00004583-199912000-00005
   Remington G, 2001, J CLIN PSYCHOPHARM, V21, P440, DOI 10.1097/00004714-200108000-00012
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   Rosenberg RE, 2010, J AUTISM DEV DISORD, V40, P342, DOI 10.1007/s10803-009-0878-1
   Sanchez LE, 1996, J AM ACAD CHILD PSY, V35, P537, DOI 10.1097/00004583-199604000-00021
   SAXENA PR, 1995, PHARMACOL THERAPEUT, V66, P339, DOI 10.1016/0163-7258(94)00005-N
   Scahill L, 2012, J AUTISM DEV DISORD, V42, P432, DOI 10.1007/s10803-011-1251-8
   Scahill L, 2006, J AM ACAD CHILD PSY, V45, P1114, DOI 10.1097/01.chi.0000220854.79144.e7
   Sinha Y, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003681.pub3
   Sugie Y, 2005, J AUTISM DEV DISORD, V35, P377, DOI 10.1007/s10803-005-3305-2
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   The Nordic Cochrane Centre The Cochrane Collaboration, 2012, REV MAN REVMAN 5 2
   Williams JG, 2006, ARCH DIS CHILD, V91, P8, DOI 10.1136/adc.2004.062083
   Williams K, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004677.pub2
   World Health Organization, 1993, INT CLASS DIS ICD 10
NR 53
TC 5
Z9 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2013
IS 8
AR CD004677
DI 10.1002/14651858.CD004677.pub3
PG 51
WC Medicine, General & Internal
SC General & Internal Medicine
GA 211RT
UT WOS:000323928600027
ER

PT J
AU Al-Ayadhi, LY
   Elamin, NE
AF Al-Ayadhi, Laila Y.
   Elamin, Nadra Elyass
TI Camel Milk as a Potential Therapy as an Antioxidant in Autism Spectrum
   Disorder (ASD)
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID INCREASED LIPID-PEROXIDATION; RANDOMIZED CONTROLLED-TRIAL; OXIDATIVE
   STRESS; SUPEROXIDE-DISMUTASE; PARKINSONS-DISEASE; ENERGY-METABOLISM;
   GLYCEMIC CONTROL; CHILDREN; MYELOPEROXIDASE; ENZYMES
AB Extensive studies have demonstrated that oxidative stress plays a vital role in the pathology of several neurological diseases, including autism spectrum disorder (ASD); those studies proposed that GSH and antioxidant enzymes have a pathophysiological role in autism. Furthermore, camel milk has emerged to have potential therapeutic effects in autism. The aim of the current study was to evaluate the effect of camel milk consumption on oxidative stress biomarkers in autistic children, by measuring the plasma levels of glutathione, superoxide dismutase, and myeloperoxidase before and 2 weeks after camel milk consumption, using the ELISA technique. All measured parameters exhibited significant increase after camel milk consumption (P < 0.5). These findings suggest that camel milk could play an important role in decreasing oxidative stress by alteration of antioxidant enzymes and nonenzymatic antioxidant molecules levels, as well as the improvement of autistic behaviour as demonstrated by the improved Childhood Autism Rating Scale (CARS).
C1 [Al-Ayadhi, Laila Y.] King Saud Univ, Dept Physiol, Fac Med, Riyadh 11461, Saudi Arabia.
   [Elamin, Nadra Elyass] King Saud Univ, Fac Med, Autism Res & Treatment Ctr, Shaik Al Amodi Autism Res Chair, Riyadh 11461, Saudi Arabia.
RP Al-Ayadhi, LY (reprint author), King Saud Univ, Dept Physiol, Fac Med, POB 2925, Riyadh 11461, Saudi Arabia.
EM ayadh2@gmail.com
CR Agrawal RP, 2005, DIABETES RES CLIN PR, V68, P176, DOI 10.1016/j.diabres.2004.12.007
   Agrawal RP, 2011, EUR J CLIN NUTR, V65, P1048, DOI 10.1038/ejcn.2011.98
   Akyol O, 2002, PROG NEURO-PSYCHOPH, V26, P995, DOI 10.1016/S0278-5846(02)00220-8
   Al-Ayadhi L. Y., 2013, J NEUROINFLAMMATION, V10
   AL-Ayadhi L. Y., 2012, J NEUROINFLAMMATION, V9
   El-Ansary A, 2010, CLIN BIOCHEM, V43, P63, DOI 10.1016/j.clinbiochem.2009.09.008
   Al-Gadani Y, 2009, CLIN BIOCHEM, V42, P1032, DOI 10.1016/j.clinbiochem.2009.03.011
   Al-Humaid A. I., 2010, American Journal of Food Technology, V5, P22
   Al-Mosalem OA, 2009, CLIN BIOCHEM, V42, P949, DOI 10.1016/j.clinbiochem.2009.04.006
   Al-wabel N. A., 2012, WEBMEDCENTRAL VET ME, V3
   Al-Yafee YA, 2011, BMC NEUROL, V11, DOI 10.1186/1471-2377-11-139
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Andreazza AC, 2008, J AFFECT DISORDERS, V111, P135, DOI 10.1016/j.jad.2008.04.013
   Anthony A. K., 2009, J CLIN EXP GASTROENT, V2, P85
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
   Bolte S, 2002, CHILD PSYCHIAT HUM D, V33, P165, DOI 10.1023/A:1020734325815
   Bostantjopoulou S, 1997, FUNCT NEUROL, V12, P63
   CASTELLOE P, 1993, J AUTISM DEV DISORD, V23, P229, DOI 10.1007/BF01046217
   Chauhan A, 2004, LIFE SCI, V75, P2539, DOI 10.1016/j.lfs.2004.04.038
   Choi DK, 2005, J NEUROSCI, V25, P6594, DOI 10.1523/JNEUROSCI.0970-05.2005
   Christen Y, 2000, AM J CLIN NUTR, V71, p621S
   El Heni J., 2011, ECOTOXICOLOGY ENV SA, V74, P2099
   Faber S, 2009, BIOMARKERS, V14, P171, DOI 10.1080/13547500902783747
   Green PS, 2004, J NEUROCHEM, V90, P724, DOI 10.1111/j.1471-4159.2004.02527.x
   Horvath K, 2002, CURR OPIN PEDIATR, V14, P583, DOI 10.1097/01.MOP.0000030221.71203.46
   Kannan K, 2000, PATHOPHYSIOLOGY, V7, P153, DOI DOI 10.1016/S0928-4680(00)00053-5
   Kappeler S, 1998, J DAIRY RES, V65, P209, DOI 10.1017/S0022029997002847
   Kappeler S, 1998, THESIS SWISS FEDERAL
   Klevay L., 2003, P 1 INT BIOM S TRAC
   Knivsberg AM, 1995, SCAND J EDUC RES, V39, P223, DOI 10.1080/0031383950390304
   Knivsberg AM, 2002, NUTR NEUROSCI, V5, P251, DOI 10.1080/10281450290028945
   Kurutas EB, 2005, MEDIAT INFLAMM, P390, DOI 10.1155/MI.2005.390
   Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X
   McGinnis W. R., 2005, INTEGRATIVE MED, V3, P42
   McGinnis WR, 2004, ALTERN THER HEALTH M, V10, P22
   Meguid NA, 2011, BIOL TRACE ELEM RES, V143, P58, DOI 10.1007/s12011-010-8840-9
   Mohamed HE, 2005, J ANIM PHYSIOL AN N, V89, P35, DOI 10.1111/j.1439-0396.2004.00507.x
   Momeni N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.19
   Nagra RM, 1997, J NEUROIMMUNOL, V78, P97, DOI 10.1016/S0165-5728(97)00089-1
   Powell S.R, 2000, J NUTR, V130, P1447
   Rahman I, 2005, ANTIOXID REDOX SIGN, V7, P42, DOI 10.1089/ars.2005.7.42
   Rose S, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.61
   Russo A. J., 2009, NUTR METABOLIC INSIG, V2, P27
   Saltanat Heinayat, 2009, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, V25, P431
   Schopler E, 2008, CHILDHOOD AUTISM RAT
   Shabo Y, 2005, ISRAEL MED ASSOC J, V7, P796
   Shabo Y., 2005, J ENDOCRINE GENETICS, V4, P67
   Shohami E, 1997, J CEREBR BLOOD F MET, V17, P1007
   Sogut S, 2003, CLIN CHIM ACTA, V331, P111, DOI 10.1016/S0009-8981(03)00119-0
   Veenstra-VanderWeele J, 2004, MOL PSYCHIATR, V9, P819, DOI 10.1038/sj.mp.4001505
   White JF, 2003, EXP BIOL MED, V228, P639
   Yagil R., 2004, CAMEL MILK AUTOIMMUN
   Yorbik O, 2002, PROSTAG LEUKOTR ESS, V67, P341, DOI 10.1054/plef.439
   Zafra O, 2011, ENVIRON MICROBIOL, V13, P960, DOI 10.1111/j.1462-2920.2010.02401.x
   Zoroglu SS, 2004, EUR ARCH PSY CLIN N, V254, P143, DOI 10.1007/s00406-004-0456-7
NR 56
TC 1
Z9 1
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1741-427X
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
AR 602834
DI 10.1155/2013/602834
PG 8
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 215ED
UT WOS:000324191300001
ER

PT J
AU Walters, JB
   Hughes, TL
   Sutton, LR
   Marshall, SN
   Crothers, LM
   Lehman, C
   Paserba, D
   Talkington, V
   Taormina, R
   Huang, A
AF Walters, Jessica Bleil
   Hughes, Tammy L.
   Sutton, Lawrence R.
   Marshall, Stephanie N.
   Crothers, Laura M.
   Lehman, Cathryn
   Paserba, Dave
   Talkington, Vanessa
   Taormina, Rochelle
   Huang, Ann
TI Maltreatment and Depression in Adolescent Sexual Offenders with an
   Autism Spectrum Disorder
SO JOURNAL OF CHILD SEXUAL ABUSE
LA English
DT Article
DE emotional abuse; emotional neglect; treatment needs; adolescents
ID ABUSE; CHILDREN; IMPACT; VICTIMIZATION; DISABILITIES; PERSPECTIVE;
   BEHAVIORS; COMMUNITY
AB This study examined the self-reported presence and severity of abuse, neglect, and depressive symptoms for 43 adolescents adjudicated delinquent due to a sexual offense. Twenty-seven of the adolescent sexual offenders were also diagnosed with an autism spectrum disorder, and 16 did not carry an autism spectrum disorder diagnosis. Both groups reported moderate to high levels of abuse and neglect. Adolescent sexual offenders with an autism spectrum disorder reported significantly higher depressive symptoms than those without an autism spectrum disorder. Furthermore, of the group with an autism spectrum disorder, those reporting severe levels of emotional abuse and/or emotional neglect were more likely to also have depressive symptoms. Results suggest a need to tailor treatment programs to match the unique needs of sexual offenders.
C1 [Walters, Jessica Bleil; Sutton, Lawrence R.; Lehman, Cathryn; Paserba, Dave; Talkington, Vanessa; Taormina, Rochelle] Duquesne Univ, Pittsburgh, PA 15258 USA.
   [Walters, Jessica Bleil; Hughes, Tammy L.; Huang, Ann] Duquesne Univ, Dept Counseling Psychol & Special Educ, Pittsburgh, PA 15258 USA.
   [Marshall, Stephanie N.] Duquesne Univ, Sch Psychol Program, Pittsburgh, PA 15258 USA.
   [Crothers, Laura M.] Duquesne Univ, Dept Counseling Psychol & Special Educ, Sch Psychol, Pittsburgh, PA 15258 USA.
RP Walters, JB (reprint author), Duquesne Univ, Dept Counseling Psychol & Special Educ, 102C Canevin Hall, Pittsburgh, PA 15258 USA.
EM bleilj@hotmail.com
CR AllardDansereau C, 1997, CHILD ABUSE NEGLECT, V21, P965, DOI 10.1016/S0145-2134(97)00057-4
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   AMMERMAN RT, 1989, CHILD ABUSE NEGLECT, V13, P335, DOI 10.1016/0145-2134(89)90073-2
   Beck A. T., 1996, BECK DEPRESSION INVE, V2nd
   BECKER JV, 1991, CHILD ABUSE NEGLECT, V15, P531, DOI 10.1016/0145-2134(91)90037-E
   Bernstein D. P., 1997, CHILDHOOD TRAUMA QUE
   Bray-Garretson H., 2004, SEXUAL ADDICTION COM, V11, P265, DOI DOI 10.1080/10720160490900614
   Briere J., 1991, NEW DIR MENT HLTH SE, V51, P3
   BROWNE A, 1986, PSYCHOL BULL, V99, P66, DOI 10.1037//0033-2909.99.1.66
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Burton DL, 2002, CHILD ABUSE NEGLECT, V26, P893, DOI 10.1016/S0145-2134(02)00360-5
   Cashwell C. S., 1997, J MENTAL HLTH COUNSE, V19, P346
   DAY K, 1994, BRIT J PSYCHIAT, V165, P630, DOI 10.1192/bjp.165.5.630
   FREEMANLONGO RE, 1986, CHILD ABUSE NEGLECT, V10, P411, DOI 10.1016/0145-2134(86)90017-7
   Fujikawa Y., 2002, JAPANESE J CHILD ADO, V43, P280
   Ghaziuddin M, 2002, J AUTISM DEV DISORD, V32, P299, DOI 10.1023/A:1016330802348
   Gorman-Smith D., 1992, SEXUAL ABUSE CHILDRE, V1, P285
   Griffiths D. M., 1989, CHANGING INAPPROPRIA
   Hanson R. K., 1988, ANN SEX RES, V1, P485, DOI 10.1007/BF00854712
   Haracopos D., 1999, AUTISM SEXUALITY A D
   Haskins BG, 2006, J AM ACAD PSYCHIATRY, V34, P374
   Hilton N. Z., 1993, INT J OFFENDER THER, V37, P287, DOI DOI 10.1177/0306624X9303700402
   Howlin P, 2000, AUTISM, V4, P63, DOI DOI 10.1177/1362361300004001005
   Jonson-Reid M, 2001, AM J ORTHOPSYCHIAT, V71, P120, DOI 10.1037//0002-9432.71.1.120
   KENDALLTACKETT KA, 1993, PSYCHOL BULL, V113, P164, DOI 10.1037//0033-2909.113.1.164
   Koller R, 2000, SEX DISABIL, V18, P125, DOI 10.1023/A:1005567030442
   Konstantareas MM, 1997, J AUTISM DEV DISORD, V27, P397, DOI 10.1023/A:1025805405188
   Lee JKP, 2002, CHILD ABUSE NEGLECT, V26, P73, DOI 10.1016/S0145-2134(01)00304-0
   Mandell DS, 2005, CHILD ABUSE NEGLECT, V29, P1359, DOI 10.1016/j.chiabu.2005.06.006
   Mansell S., 1996, AURORA PROJECT THERA
   Mansell S, 1998, MENT RETARD, V36, P12, DOI 10.1352/0047-6765(1998)036<0012:CFASAC>2.0.CO;2
   Mash E. J., 1996, CHILD PSYCHOPATHOLOG
   Mullen PE, 1996, CHILD ABUSE NEGLECT, V20, P7, DOI 10.1016/0145-2134(95)00112-3
   MURRIE D. C., 2002, INT J FORENSIC MENTA, V1, P59, DOI DOI 10.1080/14999013.2002.10471161
   Myles B. S., 2000, ASPERGERS SYNDROME D
   O'Callaghan D, 1998, CHILD ABUSE REV, V7, P435, DOI DOI 10.1002/(SICI)1099-0852(199811/12)7:6<435::AID-CAR517>3.3.C0;2-6
   Pennsylvania Department of Public Welfare, 2007, PENNS AUT ASS DIAGN
   Price D., 2003, SEXUAL ADDICTION COM, V10, P225, DOI DOI 10.1080/10720160390268924
   Rasmussen LA, 2013, J CHILD SEX ABUS, V22, P119, DOI 10.1080/10538712.2013.744646
   Realmuto GM, 1999, J AUTISM DEV DISORD, V29, P121, DOI 10.1023/A:1023088526314
   Riser DK, 2013, J CHILD SEX ABUS, V22, P9, DOI 10.1080/10538712.2013.735355
   Ryan G, 1996, J AM ACAD CHILD PSY, V35, P17, DOI 10.1097/00004583-199601000-00008
   Shirk S. R., 1996, CHANGE PROCESSES CHI
   Snyder H. N., 2006, JUVENILE OFFENDERS V
   Snyder H. N., 1999, JUVENILE OFFENDERS V
   Sobsey D., 1997, DEV DISABILITIES B, V25, P77
   Sobsey D., 1994, VIOLENCE ABUSE LIVES
   Stokes MA, 2005, AUTISM, V9, P266, DOI 10.1177/1362361305053258
   Sullivan PM, 2000, CHILD ABUSE NEGLECT, V24, P1257, DOI 10.1016/S0145-2134(00)00190-3
   Sutton L. R., FOCUS AUTIS IN PRESS
   Thalheimer W., 2002, CALCULATE EFFECT SIZ
   Tyler Kimberly A, 2006, Violence Vict, V21, P287, DOI 10.1891/vivi.21.3.287
   Veneziano C, 2000, J INTERPERS VIOLENCE, V15, P363, DOI 10.1177/088626000015004002
   Veneziano C., 2002, TRAUMA VIOLENCE ABUS, V3, P247, DOI 10.1177/1524838002237329
   WORLING JR, 1995, INT J OFFENDER THER, V39, P276, DOI 10.1177/0306624X9503900308
NR 55
TC 5
Z9 5
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1053-8712
EI 1547-0679
J9 J CHILD SEX ABUS
JI J. Child Sex. Abus.
PD JAN 1
PY 2013
VL 22
IS 1
SI SI
BP 72
EP 89
DI 10.1080/10538712.2013.735357
PG 18
WC Psychology, Clinical; Family Studies
SC Psychology; Family Studies
GA 210WG
UT WOS:000323864900005
ER

PT J
AU Rotta, NT
AF Rotta, Newra Tellechea
TI Autism spectrum disorder and specific language disorder are two
   different entities or a continuum of neuropsychological manifestations?
SO MEDICINA-BUENOS AIRES
LA Spanish
DT Article
DE autism; language; DSM-IV; DSM-V
ID WILLIAMS-SYNDROME; IMPAIRMENT; CHILDREN; ASSOCIATION; VALIDATION;
   INTERVIEW
AB Autism spectrum disorder and specific language disorder are two different entities or a continuum of neuropsychological manifestations? Follow-up of children with delayed language development underscores the fact that, in several cases, language difficulties coexist with other symptoms such as social behavior changes. Autism spectrum disorder (ASD) and language specific disorder (LSD) are developmental disorders that are defined differently, but have some common language and social behavior characteristics which impose diagnostic difficulties. For this reason it is believed that they may share not only symptomatic but also ethiological aspects. With that in mind, we performed a literature search of works that discussed and, with their results, clarified this issue. Although several studies have allowed clearer and frequent diagnosis of both ASD and LSD, many cases persist in which the question in this article's title cannot be clearly answered, especially in children younger than two years of age.
C1 Univ Fed Rio Grande do Sul, BR-90430181 Porto Alegre, RS, Brazil.
RP Rotta, NT (reprint author), Univ Fed Rio Grande do Sul, Rua Mariante,239-202 Rio Branco, BR-90430181 Porto Alegre, RS, Brazil.
EM nrotta@terra.com.br
CR Abeduto L, 2004, DEV LANGUAGE DISORDE
   Allen D, 2002, NEUROBIOLOGY INFANTI, P73
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   [Anonymous], 2011, DSM5 DEV 299 00 AUT
   Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075
   Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
   Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
   Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
   Constantino JN, 2009, J AM ACAD CHILD PSY, V48, P97, DOI 10.1097/CHI.0b013e318193069e
   Fischer S.E, 2005, APPL PSICHOLINQUISTI, V26, P111
   Frazier TW, 2010, ASSESSMENT, V17, P308, DOI 10.1177/1073191109356534
   Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
   Frombonne E., 2000, J AUTISM DEV DISORD, V30, P365
   Frombonne E., 2009, PEDIATR RES, V65, P591
   Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Herbert MR, 2002, ANN NEUROL, V52, P588, DOI 10.1002/ana.10349
   Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032
   Herbert MR, 2005, BRAIN, V128, P213, DOI 10.1093/brain/awh330
   Herbert MR, 2003, DEVELOPMENTAL SCI, V6, P11
   Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199
   Lee H, 2010, AM J MED GENET B, V153B, P1119, DOI 10.1002/ajmg.b.31103
   Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x
   Mervis CB, 2004, DEV LANGUAGE DISORDE
   Mildenberger K, 2001, EUR CHILD ADOLES PSY, V10, P248
   Muller RA, 2005, APPL PSYCHOLINGUIST, V26, P65, DOI 10.1017/S014271640505006X
   Phillips C, 2005, APPL PSYCHOLINGUIST, V26, P79, DOI 10.1017/S0142716405050071
   Rapin I., 2010, CLIN DEV MED, V139
   Rescorla L., 2003, SOC RES CHILD DEV AB, V9, P566
   Rice M L, 2005, LANGUAGE SYMPTOMS DE
   Rice ML, 2005, DEV LANGUAGE DISORDE
   Rice ML, 2005, APPL PSYCHOLINGUIST, V26, P7, DOI 10.1017/S0142716405050034
   Rice ML, 2004, J SPEECH LANG HEAR R, V47, P816, DOI 10.1044/1092-4388(2004/061)
   Ronald A, 2008, J CHILD PSYCHOL PSYC, V35, P539
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Santosh PJ, 2009, EUR CHILD ADOLES PSY, V18, P521, DOI 10.1007/s00787-009-0004-0
   Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008
   Tanner L., 2010, ABC NEWS HLTH
   Williams D, 2013, J AUTISM DEV DISORD, V43, P404, DOI 10.1007/s10803-012-1579-8
NR 39
TC 0
Z9 0
PU MEDICINA (BUENOS AIRES)
PI BUENOS AIRES
PA DONATO ALVAREZ 3150, 1427 BUENOS AIRES, ARGENTINA
SN 0025-7680
J9 MEDICINA-BUENOS AIRE
JI Med.-Buenos Aires
PY 2013
VL 73
SU 1
BP 10
EP 15
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 215PF
UT WOS:000324222000003
ER

PT J
AU Riesgo, RD
   Ranzan, MMBJ
   Winckler, MIB
   Ohlweiler, L
AF Riesgo, Rudimar Dos Santos
   Becker Josiane Ranzan, Michele Michelin
   Bragatti Winckler, Maria Isabel
   Ohlweiler, Lygia
TI Follow up of patients with developmental delay and autistic spectrum
   disorder
SO MEDICINA-BUENOS AIRES
LA Spanish
DT Article
DE autism; adult; follow up; prognosis
ID RECEPTIVE LANGUAGE DISORDER; EARLY ADULT LIFE; CHILDHOOD; ADOLESCENCE;
   TRANSLATION; VALIDATION; INTERVIEW; VALIDITY; BEHAVIOR; OUTCOMES
AB Follow up of patients with developmental delay and autistic spectrum disorder. The evolution of autism symptoms during life were revised, from childhood to adulthood. Little information is available. After a search in PubMed, no more than 40 publications address this issue. The review was divided into two parts: a) how change the three main symptoms of autism change; b) how change the other autism-associated symptoms. The three main symptoms, called "Triad of Wing" (communication problems, social skills deficits, and a restricted repertoire of interests) do not change significantly during lifetime. The diagnosis of autism remains stable during lifetime, and 80% of children continue with this diagnosis in adulthood. Furthermore, it is difficult to establish first diagnostic of autism in adults. In relation to the associated symptoms, one of the earliest are sleep disturbances and one of the most prevalent is both bipolar and anxiety disorders. Sleep disturbances are age-limited and disappear easily. Bipolar disorders are usually more severe in children with autism when compared to children without autism. The mood transitions are faster in autistic children. Anxiety is usually more intense in cognitive preserved autistic patients and tends to increase with age. The two main prognostic factors for autism in adults are: a) total IQ above 70. b) functional language before 6 years of age.
C1 [Riesgo, Rudimar Dos Santos; Becker Josiane Ranzan, Michele Michelin; Bragatti Winckler, Maria Isabel; Ohlweiler, Lygia] Univ Fed Rio Grande do Sul, HCPA, Unidade Neuropediat, Porto Alegre, RS, Brazil.
RP Riesgo, RD (reprint author), Rua Gen Rondon,165 Casa 13, BR-91900120 Porto Alegre, RS, Brazil.
EM rriesgo@hcpa.ufrgs.br
CR ABRAMSON RK, 1992, J AM ACAD CHILD PSY, V31, P370, DOI 10.1097/00004583-199203000-00030
   Arora M, 2011, SOUTH MED J, V104, P264, DOI 10.1097/SMJ.0b013e31820c015d
   Association A.P., 2002, MAN DIAGN EST TRANST, P73
   Becker MM, 2012, ARQ NEURO-PSIQUIAT, V70, P185, DOI 10.1590/S0004-282X2012000300006
   Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
   Cederlund M, 2010, RES DEV DISABIL, V31, P287, DOI 10.1016/j.ridd.2009.09.006
   Gottfried C., 2011, AUTISM SPECTRUM DISO, P23
   Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
   Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Kanner L, 1943, NERV CHILD, V2, P217
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Marteleto MRF, 2005, REV BRAS PSIQUIATR, V27, P295, DOI 10.1590/S1516-44462005000400008
   Mawhood L, 2000, J CHILD PSYCHOL PSYC, V41, P547, DOI 10.1017/S002196309900579X
   Pereira A, 2008, J PEDIAT, V84, P487, DOI [10.2223/JPED.1828, 10.1590/S0021-75572008000700004]
   Rotta NT, 2005, ROTINAS NEUROPEDIATR, P161
   RUTTER M, 1967, BRIT J PSYCHIAT, V113, P1183, DOI 10.1192/bjp.113.504.1183
   Sato FP, 2009, REV BRAS PSIQUIATR, V31, P30, DOI 10.1590/S1516-44462009000100008
   Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b
   Stahlberg O, 2004, J NEURAL TRANSM, V111, P891, DOI 10.1007/s00702-004-0115-1
   SZATMARI P, 1995, J AM ACAD CHILD PSY, V34, P1662, DOI 10.1097/00004583-199512000-00017
NR 21
TC 0
Z9 0
PU MEDICINA (BUENOS AIRES)
PI BUENOS AIRES
PA DONATO ALVAREZ 3150, 1427 BUENOS AIRES, ARGENTINA
SN 0025-7680
J9 MEDICINA-BUENOS AIRE
JI Med.-Buenos Aires
PY 2013
VL 73
SU 1
BP 16
EP 19
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 215PF
UT WOS:000324222000004
ER

PT J
AU Arberas, C
   Ruggieri, V
AF Arberas, Claudia
   Ruggieri, Victor
TI Autism and epigenetic. A model of explanation for the understanding of
   the genesis in autism spectrum disorders
SO MEDICINA-BUENOS AIRES
LA Spanish
DT Article
DE autism; epigenetic; Rett syndrome; fragile X syndrome; Angelman syndrome
ID FRAGILE-X-SYNDROME; DNA METHYLATION; DEVELOPMENTAL DISORDERS;
   ENVIRONMENTAL SIGNALS; ADULT HYPERTENSION; RETT-SYNDROME; MEMORY; MECP2;
   EXPRESSION; PLACENTA
AB Autism and epigenetic. Autism spectrum disorders are characterized by impairment of social integration and language development and restricted interests. Autism spectrum disorders manifest during childhood and may have a varying clinical expression over the years related to different therapeutic approaches, behavior-modifying drugs, and environmental factors, among others. So far, the genetic alterations identified are not sufficient to explain the genesis of all these processes, as many of the mutations found are also present in unaffected individuals. Findings on the underlying biological and pathophysiological mechanisms of entities strongly associated with autism spectrum disorders, such as Rett, fragile X, Angelman, and fetal alcohol syndromes, point to the role of epigenetic changes in disorders of neurodevelopment. Epigenetic phenomena are normal biological processes necessary for cell and thus human life, especially related to embryonic development. Different phenomena that affect epigenetic processes (changes that change operation or expression of a gene, without modifying the DNA structure) have also been shown to be important in the genesis of neurodevelopmental disorders. Alterations in the epigenetic mechanism may be reversible, which may explain the variation in the autism phenotype over time. Here we analyze the normal epigenetic mechanisms, autism spectrum disorders, their association with specific entities associated with altered epigenetic mechanisms, and possible therapeutic approaches targeting these alterations.
C1 [Arberas, Claudia] Hosp Ninos Dr Ricardo Gutierrez, Secc Genet Med, Buenos Aires, DF, Argentina.
   [Ruggieri, Victor] Hosp Pediat Prof Dr JP Garrahan, Serv Neurol, RA-1245 Buenos Aires, DF, Argentina.
RP Ruggieri, V (reprint author), Hosp Pediat Prof Dr JP Garrahan, Serv Neurol, Combate de los Pozos 1881, RA-1245 Buenos Aires, DF, Argentina.
EM victorruggieri@gmail.com
CR Adegbola A, 2008, AM J MED GENET A, V146A, P505, DOI 10.1002/ajmg.a.32142
   Allan AM, 2008, HUM MOL GENET, V17, P2047, DOI 10.1093/hmg/ddn102
   Allis C. D., 2007, EPIGENETICS, P23
   Amir RE, 1999, NAT GENET, V23, P185
   Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Barrett RM, 2008, LEARN MEMORY, V15, P460, DOI 10.1101/lm.917508
   Bartel DP, 2004, CELL, V116, P281, DOI 10.1016/S0092-8674(04)00045-5
   Bayley A, 1998, J AUTISM DEV DISORD, V28, P369
   Bell JT, 2011, TRENDS GENET, V27, P116, DOI 10.1016/j.tig.2010.12.005
   Berger SL, 2009, GENE DEV, V23, P781, DOI 10.1101/gad.1787609
   Bockmuhl Y., 2010, EPIGENETICS, V5, P194
   BOYES J, 1991, CELL, V64, P1123, DOI 10.1016/0092-8674(91)90267-3
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Costa F, 2010, CANC MANAG RES, V2, P255
   Dolen G, 2009, J NEURODEV DISORD, V1, P133, DOI 10.1007/s11689-009-9015-x
   Dolen G, 2005, NEURON, V45, P642, DOI 10.1016/j.neuron.2005.02.021
   Emmitte KA, 2013, EXPERT OPIN THER PAT, V23, P393, DOI 10.1517/13543776.2013.760544
   Folstein Susan, 1996, Current Opinion in Pediatrics, V8, P339, DOI 10.1097/00008480-199608000-00007
   Gluckman PD, 2008, NEW ENGL J MED, V359, P61, DOI 10.1056/NEJMra0708473
   Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
   Hagerman PJ, 2008, J MED GENET, V45, P498, DOI 10.1136/jmg.2008.059055
   Hagerman RJ, 2008, CURR PEDIAT REV, V4, P40, DOI DOI 10.2174/157339608783565770
   Haig D, 2004, COLD SPRING HARB SYM, V69, P67, DOI 10.1101/sqb.2004.69.67
   Healy A, 2011, ACS CHEM NEUROSCI, V2, P402, DOI 10.1021/cn200019z
   Hendrich B, 1998, MOL CELL BIOL, V18, P6538
   Herceg Z, 2012, EPIGENOMICS, V3, P383
   Jaenisch R, 2003, NAT GENET, V33, P245, DOI 10.1038/ng1089
   Kaminen-Ahola N, 2010, PLOS GENET, V6, P1
   Kanner L, 1943, NERV CHILD, V2, P217
   Kubota T, 2010, J PHARMACOL SCI, V113, P3, DOI 10.1254/jphs.09R20FM
   Kuzawa C, 2008, EVOLUTION HLTH DIS, P253
   LaSalle JM, 2007, EPIGENETICS, V2, P5
   LeCouteur A, 1996, J CHILD PSYCHOL PSYC, V37, P785
   Levenson JM, 2005, NAT REV NEUROSCI, V6, P108, DOI 10.1038/nrn1604
   Maccani MA, 2009, AM J REPROD IMMUNOL, V62, P78, DOI 10.1111/j.1600-0897.2009.00716.x
   McGowan PO, 2008, BRAIN RES, V1237, P12, DOI 10.1016/j.brainres.2008.07.074
   McQuown SC, 2010, CURR PSYCHIAT REP, V12, P145, DOI 10.1007/s11920-010-0099-5
   Mehler MF, 2009, BRAIN RES REV, V59, P388, DOI 10.1016/j.brainresrev.2008.11.001
   Mehler MF., 2008, BRAIN RES REV, V59, P388
   MOHANDAS T, 1981, SCIENCE, V211, P393, DOI 10.1126/science.6164095
   Monk D, 2006, P NATL ACAD SCI USA, V103, P6623, DOI 10.1073/pnas.0511031103
   Na ES, 2013, NEUROPSYCHOPHARMACOL, V38, P212, DOI 10.1038/npp.2012.116
   Quinlan J, 2007, J AM SOC NEPHROL, V18, P1915, DOI 10.1681/ASN.2006101107
   Ramos PS, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-4
   Ravnskjaer Kim, 2012, Epigenetics, V7, P522, DOI 10.4161/epi.19933
   Resendiz M, 2013, EPIGENOMICS-UK, V5, P73, DOI [10.2217/epi.12.80, 10.2217/EPI.12.80]
   Ruggieri V., 2011, AUTISMO DIAGNOSTICO, P147
   Ruggieri V, 2007, MEDICINA-BUENOS AIRE, V67, P569
   Santos-Reboucas CB, 2007, EUR J HUM GENET, V15, P10, DOI 10.1038/sj.ejhg.5201727
   Schanen NC, 2006, HUM MOL GENET, V15, P138, DOI DOI 10.1093/HMG/DDL213
   Sherman S, 2005, GENET MED, V7, P584, DOI 10.1097/01.GIM.0000182468.22666.dd
   Skinner MK, 2009, EPIGENOMICS-UK, V1, P111, DOI 10.2217/EPI.09.11
   Szulwach KE, 2010, J CELL BIOL, V189, P127, DOI 10.1083/jcb.200908151
   Szyf M, 2009, ANNU REV PHARMACOL, V49, P243, DOI 10.1146/annurev-pharmtox-061008-103102
   Tuchman R., 2013, REV NEUROL S1, V56, P3
   Turner BM, 2002, CELL, V111, P285, DOI 10.1016/S0092-8674(02)01080-2
   Vehaskari VM, 2007, PEDIATR NEPHROL, V22, P490, DOI 10.1007/s00467-006-0353-6
   Vehaskari VM, 2001, KIDNEY INT, V59, P238, DOI 10.1046/j.1523-1755.2001.00484.x
   Waddington CH, 1940, J GENET, V41, P75, DOI 10.1007/BF02982977
   Wakeling EL, 2010, J MED GENET, V47, P760, DOI 10.1136/jmg.2010.079111
   Weksberg R, 2010, EUR J HUM GENET, V18, P8, DOI 10.1038/ejhg.2009.106
   Wolff GL, 1998, FASEB J, V12, P949
   Yasui DH, 2007, P NATL ACAD SCI USA, V4, P1916
   Zachariah RM, 2012, NEURAL PLAST, DOI 10.1155/2012/415825
   Zang Y, 2009, GENOME BIOL, V10, P138
   Zhao XY, 2007, EPIGENETICS, V2, P126
NR 67
TC 1
Z9 1
PU MEDICINA (BUENOS AIRES)
PI BUENOS AIRES
PA DONATO ALVAREZ 3150, 1427 BUENOS AIRES, ARGENTINA
SN 0025-7680
J9 MEDICINA-BUENOS AIRE
JI Med.-Buenos Aires
PY 2013
VL 73
SU 1
BP 20
EP 29
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA 215PF
UT WOS:000324222000005
PM 24072048
ER

PT J
AU Vogeley, K
AF Vogeley, Kai
TI A Social Cognitive Perspective on 'Understanding' and 'Explaining'
SO PSYCHOPATHOLOGY
LA English
DT Article
DE 'General Psychopathology' ('Allgemeine Psychopathologie');
   'Understanding' ('Verstehen'); 'Explaining' ('Erklaren'); Ambiguity;
   Social psychology; Social neuroscience
ID BRAIN; NEUROSCIENCE; AUTISM; GAZE; EYES; MIND
AB One essential methodological dichotomy introduced by Karl Jaspers into the field of psychopathology is the difference between 'understanding' ('Verstehen') and 'explaining' (Erklaren'). Jaspers emphasizes a critical epistemological divide between both methods: whereas 'explaining' relates to the attempt to consider mental disorders as consequences of impersonal natural laws, 'understanding' refers to the empathic appreciation of conflicts, hopes, and desires of an individual person. This distinction is related to the difference between 'persons' and 'things' according to Fritz Heider, founder of the so-called 'attribution theory' in social psychology that deals with our ability to ascribe mental states to others. Whereas the behavior of persons is based on psychological rules that are inherently characterized by ambiguity and uncertainty and are thus only partly predictable, the behavior of things is based on natural laws and is therefore fully predictable. This suggests a close resemblance of both accounts where 'understanding' is related to the do-main of persons and 'explaining' is related to the domain of things or physical objects. Recently, understanding others has also become a central topic of modern cognitive neuroscience, constituting 'social neuroscience' targeted at explaining our human capacity of ascribing mental states to others. This shows that this distinction introduced by Jaspers still is an important and fundamental differentiation for various research fields dealing with communication and interaction between persons. (C) 2013 S. Karger AG, Basel
C1 Univ Hosp Cologne, Dept Psychiat, DE-50924 Cologne, Germany.
RP Vogeley, K (reprint author), Univ Hosp Cologne, Dept Psychiat, Kerpener Str 62, DE-50924 Cologne, Germany.
EM kai.vogeley@uk-koeln.de
RI Vogeley, K/E-4860-2012
OI Vogeley, K/0000-0002-5891-5831
CR Argyle Michael, 1976, GAZE AND MUTUAL GAZE
   Becchio C, 2010, CURR DIR PSYCHOL SCI, V19, P183, DOI 10.1177/0963721410370131
   Bente G, 2008, BEHAV RES METHODS, V40, P269, DOI 10.3758/BRM.40.1.269
   Biocca F, 2003, PRESENCE-TELEOP VIRT, V12, P456, DOI 10.1162/105474603322761270
   Burgoon J. K., 1996, NONVERBAL COMMUNICAT
   Cacioppo JT, 2004, SAGE HDB METHODS SOC, P383
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
   Frith U, 2010, PHILOS T R SOC B, V365, P165, DOI 10.1098/rstb.2009.0160
   Georgescu AL, HUM BRAIN M IN PRESS
   Hacking Ian, 1999, SOCIAL CONSTRUCTION
   Han SH, 2013, ANNU REV PSYCHOL, V64, P335, DOI 10.1146/annurev-psych-071112-054629
   Heider F., 1958, PSYCHOL INTERPERSONA
   Jaspers K., 1997, GEN PSYCHOPATHOLOGY
   Kelley H. H., 1967, NEBRASKA S MOTIVATIO, V15, P192
   Kitayama S., 2007, HDB CULTURAL PSYCHOL
   Kupke C, 2008, J PHILOS PSYCHIAT, V1, P1
   Kuzmanovic B, 2009, NEUROIMAGE, V46, P1154, DOI 10.1016/j.neuroimage.2009.03.037
   Kuzmanovic B, 2011, RES AUTISM SPECT DIS, V5, P604, DOI 10.1016/j.rasd.2010.07.005
   Mitchell JP, 2009, TRENDS COGN SCI, V13, P246, DOI 10.1016/j.tics.2009.03.008
   Ochsner KN, 2001, AM PSYCHOL, V56, P717, DOI 10.1037//0003-066X.56.9.717
   Rizzolatti G, 2010, NAT REV NEUROSCI, V11, P264, DOI 10.1038/nrn2805
   Sanfey AG, 2003, SCIENCE, V300, P1755, DOI 10.1126/science.1082976
   Schilbach L, 2010, J COGNITIVE NEUROSCI, V22, P2702, DOI 10.1162/jocn.2009.21401
   Schilbach L, 2006, NEUROPSYCHOLOGIA, V44, P718, DOI 10.1016/j.neuropsychologia.2005.07.017
   Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
   Shamay-Tsoory SG, 2004, J CLIN EXP NEUROPSYC, V26, P1113, DOI 10.1080/13803390490515531
   Tomasello M, 2009, WHY WE COOPERATE, P1
   Vogeley K, 2001, NEUROIMAGE, V14, P170, DOI 10.1006/nimg.2001.0789
   VOGELEY K, 2009, NEUROPSYCHOLOGY MENT, P408, DOI 10.1017/CBO9780511642197.035
   Vogeley K, 2009, TRENDS COGN SCI, V13, P511, DOI 10.1016/j.tics.2009.09.006
   Wilms M, 2010, SOC COGN AFFECT NEUR, V5, P98, DOI 10.1093/scan/nsq024
   Zahavi D, 2003, J CONSCIOUSNESS STUD, V10, P53
NR 32
TC 1
Z9 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0254-4962
J9 PSYCHOPATHOLOGY
JI Psychopathology
PY 2013
VL 46
IS 5
BP 295
EP 300
DI 10.1159/000351839
PG 6
WC Psychiatry
SC Psychiatry
GA 213UH
UT WOS:000324085400004
PM 23859833
ER

PT J
AU Andersson, GW
   Miniscalco, C
   Gillberg, C
AF Andersson, Gunilla Westman
   Miniscalco, Carmela
   Gillberg, Christopher
TI Autism in Preschoolers: Does Individual Clinician's First Visit
   Diagnosis Agree with Final Comprehensive Diagnosis?
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID SPECTRUM DISORDERS; COMMUNICATION DISORDERS; INTERRATER RELIABILITY;
   CHILDREN; INTERVIEW; TODDLERS
AB Comprehensive clinical diagnosis based on all available information is considered the "gold standard" in autism spectrum disorders (ASD). We examined agreement across independent assessments (clinical judgment) of 34 young children (age 24-46 months) with suspected ASD, assessed by a multidisciplinary team, and final comprehensive clinical diagnosis. Agreement across settings and between each clinician's assessment and final diagnosis was moderate. The poorest fit was found at assessment in connection with psychological evaluation and the best with preschool observation and parent interview. Some individual clinicians had good and others had poor fit with final diagnosis. Disagreement across assessments was pronounced for girls. The findings suggest that multidisciplinary assessments remain important and that comprehensive clinical diagnosis should still be regarded as the gold standard in ASD.
C1 [Andersson, Gunilla Westman; Miniscalco, Carmela; Gillberg, Christopher] Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, S-41119 Gothenburg, Sweden.
RP Andersson, GW (reprint author), Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Kungsgatan 12, S-41119 Gothenburg, Sweden.
EM gunilla.andersson@gnc.gu.se
FU Annmari and Per Ahlqvist Foundation; Wilhelm and Martina Lundgren
   Foundation; Swedish Science Council [B41-f 1883/09]; ALF
FX The authors want to thank the staff at the CNC, all the children, and
   parents, for their help in making this study possible. Anders Pehrson
   and Nils-Gunnar Pehrson, and Statistiska konsultgruppen gave advice and
   performed the statistical analyses. The study was supported by grants
   from the Annmari and Per Ahlqvist Foundation, the Wilhelm and Martina
   Lundgren Foundation, and the Swedish Science Council (Grant no. B41-f
   1883/09) and ALF for Christopher Gillberg.
CR Alin-Akerman B., 1991, GRIFFITHS DEV SCALES
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Andersson GW, 2013, RES DEV DISABIL, V34, P413, DOI 10.1016/j.ridd.2012.08.025
   Andersson GW, 2013, SCI WORLD J, DOI 10.1155/2013/384745
   Arvidsson E., 2011, SVENSK NORMERING SPR
   Caronna EB, 2008, ARCH DIS CHILD, V93, P518, DOI 10.1136/adc.2006.115337
   Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022
   Coleman M., 2012, AUTISMS
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Edwards S., 1997, REYNELL DEV LANGUAGE
   Fernell Elisabeth, 2013, Clin Epidemiol, V5, P33, DOI 10.2147/CLEP.S41714
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Huerta M, 2012, PEDIATR CLIN N AM, V59, P103, DOI 10.1016/j.pcl.2011.10.018
   Kadesjo B, 2001, J CHILD PSYCHOL PSYC, V42, P487, DOI 10.1017/S0021963001007090
   Klin A, 2000, J AUTISM DEV DISORD, V30, P163, DOI 10.1023/A:1005415823867
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Nygren G., 2012, J AUTISM DEV DISORD, V42, P1498, DOI DOI 10.1007/S10803-012-1488-X
   Nygren G, 2009, J AUTISM DEV DISORD, V39, P730, DOI 10.1007/s10803-008-0678-z
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   SHAFFER D, 1983, ARCH GEN PSYCHIAT, V40, P1228
   Sipes M, 2011, RES AUTISM SPECT DIS, V5, P1465, DOI 10.1016/j.rasd.2011.02.007
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Steiner AM, 2012, J AUTISM DEV DISORD, V42, P1183, DOI 10.1007/s10803-011-1376-9
   Sullivan M, 2007, J AUTISM DEV DISORD, V37, P37, DOI 10.1007/s10803-006-0335-3
   Tasse MJ, 2013, INTELLECT DEV DISAB, V51, P127, DOI 10.1352/1934-9556-51.2.127
   WHO, 1993, ICD 10 CLASS MENT BE
   Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
NR 27
TC 0
Z9 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 716267
DI 10.1155/2013/716267
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 218GG
UT WOS:000324420200001
ER

PT J
AU Sharma, A
   Gokulchandran, N
   Sane, H
   Nagrajan, A
   Paranjape, A
   Kulkarni, P
   Shetty, A
   Mishra, P
   Kali, M
   Biju, H
   Badhe, P
AF Sharma, Alok
   Gokulchandran, Nandini
   Sane, Hemangi
   Nagrajan, Anjana
   Paranjape, Amruta
   Kulkarni, Pooja
   Shetty, Akshata
   Mishra, Priti
   Kali, Mrudula
   Biju, Hema
   Badhe, Prerna
TI Autologous Bone Marrow Mononuclear Cell Therapy for Autism: An Open
   Label Proof of Concept Study
SO STEM CELLS INTERNATIONAL
LA English
DT Article
ID SPINAL-CORD-INJURY; LUMBAR PUNCTURE TECHNIQUE; SPECTRUM DISORDERS;
   STEM-CELLS; SOCIAL BRAIN; RELATIVE SENSITIVITY; RATING-SCALE; CHILDREN;
   INTERVENTIONS; DEPRESSION
AB Cellular therapy is an emerging therapeutic modality with a great potential for the treatment of autism. Recent findings show that the major underlying pathogenetic mechanisms of autism are hypoperfusion and immune alterations in the brain. So conceptually, cellular therapy which facilitates counteractive processes of improving perfusion by angiogenesis and balancing inflammation by immune regulation would exhibit beneficial clinical effects in patients with autism. This is an open label proof of concept study of autologous bone marrow mononuclear cells (BMMNCs) intrathecal transplantation in 32 patients with autism followed by multidisciplinary therapies. All patients were followed up for 26 months (mean 12.7). Outcome measures used were ISAA, CGI, and FIM/Wee-FIM scales. Positron Emission Tomography-Computed Tomography (PET-CT) scan recorded objective changes. Out of 32 patients, a total of 29 (91%) patients improved on total ISAA scores and 20 patients (62%) showed decreased severity on CGI-I. The difference between pre- and postscores was statistically significant (P<0.001) on Wilcoxon matched-pairs signed rank test. On CGI-II 96% of patients showed global improvement. The efficacy was measured on CGI-III efficacy index. Few adverse events including seizures in three patients were controlled with medications. The encouraging results of this leading clinical study provide future directions for application of cellular therapy in autism.
C1 [Sharma, Alok; Gokulchandran, Nandini; Badhe, Prerna] Surana Sethia Hosp & Res Ctr, NeuroGen Brain & Spine Inst, Dept Med Serv & Clin Res, Bombay 400071, Maharashtra, India.
   [Sane, Hemangi; Kulkarni, Pooja] Surana Sethia Hosp & Res Ctr, NeuroGen Brain & Spine Inst, Dept Res & Dev, Bombay 400071, Maharashtra, India.
   [Nagrajan, Anjana; Paranjape, Amruta; Shetty, Akshata; Mishra, Priti; Kali, Mrudula; Biju, Hema] Surana Sethia Hosp & Res Ctr, NeuroGen Brain & Spine Inst, Dept NeuroRehabil, Bombay 400071, Maharashtra, India.
RP Kulkarni, P (reprint author), Surana Sethia Hosp & Res Ctr, NeuroGen Brain & Spine Inst, Dept Res & Dev, Sion Trombay Rd, Bombay 400071, Maharashtra, India.
EM poojakul28@gmail.com
CR Allison T, 2000, TRENDS COGN SCI, V4, P267, DOI 10.1016/S1364-6613(00)01501-1
   Anagnostou E, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-4
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Bradstreet JJ, 2010, ALTERN MED REV, V15, P15
   BROTHERS L, 1990, BEHAV BRAIN RES, V41, P199, DOI 10.1016/0166-4328(90)90108-Q
   Callera F, 2006, EXP HEMATOL, V34, P130, DOI 10.1016/j.exphem.2005.11.006
   Callera F, 2007, STEM CELLS DEV, V16, P461, DOI 10.1089/scd.2007.0083
   Carlson RV, 2004, BRIT J CLIN PHARMACO, V57, P695, DOI 10.1111/j.1365-2125.2004.02103.x
   Case-Smith J, 2008, AM J OCCUP THER, V62, P416
   Chen G., 2013, J TRANSL MED, V26, P21
   Chugani DC, 2012, PEDIATR CLIN N AM, V59, P63, DOI 10.1016/j.pcl.2011.10.002
   Cohly HHP, 2005, INT REV NEUROBIOL, V71, P317, DOI 10.1016/S0074-7742(05)71013-8
   Connolly AM, 2006, BIOL PSYCHIAT, V59, P354, DOI 10.1016/j.biopsych.2005.07.004
   Frith U, 2010, PHILOS T R SOC B, V365, P165, DOI 10.1098/rstb.2009.0160
   Fujita Y, 2010, STROKE, V41, P2938, DOI 10.1161/STROKEAHA.110.596379
   Galuska László, 2002, Orv Hetil, V143, P1302
   Gatto L., 2010, FRONTLINE SYNAPTIC N, V7, P2
   Geffner LF, 2008, CELL TRANSPLANT, V17, P1277
   Gerrard P., 2013, ARCH PHYS MED REHABI
   Glover LE, 2012, TRANSL STROKE RES, V3, P90, DOI 10.1007/s12975-011-0127-8
   Gotts SJ, 2012, BRAIN, V135, P2711, DOI 10.1093/brain/aws160
   Gray S, 2012, NEUROPHARMACOLOGY, V68, P136
   Grove JE, 2004, STEM CELLS, V22, P487, DOI 10.1634/stemcells.22-4-487
   Hashimoto T, 2000, PEDIATR NEUROL, V23, P416, DOI 10.1016/S0887-8994(00)00224-1
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   Hollander E, 2012, AM J PSYCHIAT, V169, P292, DOI 10.1176/appi.ajp.2011.10050764
   Ichim TE, 2007, J TRANSL MED, V5, DOI 10.1186/1479-5876-5-30
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Jordan I, 2012, PSYCHOPHARMACOLOGY, V223, P357, DOI 10.1007/s00213-012-2723-z
   Kadouri A, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-7
   Khan A, 2002, INT CLIN PSYCHOPHARM, V17, P281, DOI 10.1097/00004850-200211000-00003
   Khan AA, 2008, TRANSPL P, V40, P1140, DOI 10.1016/j.transproceed.2008.03.111
   Kishk NA, 2010, NEUROREHAB NEURAL RE, V24, P702, DOI 10.1177/1545968310369801
   Kopetz P. B., 2012, J SOCIAL SCI, V8, P196, DOI DOI 10.3844/JSSP.2012.196.201
   Leucht S, 2006, NEUROPSYCHOPHARMACOL, V31, P406, DOI 10.1038/sj.npp.1300873
   Meng JH, 2011, NEUROMUSCULAR DISORD, V21, P4, DOI 10.1016/j.nmd.2010.10.004
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   Nakano-Doi A, 2010, STEM CELLS, V28, P1292, DOI 10.1002/stem.454
   Natrajan P., 2008, SCI REPORT RES PROJE
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   Pelacho B, 2011, J CARDIOVASC TRANSL, V4, P154, DOI 10.1007/s12265-010-9245-z
   Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
   Petit I, 2002, NAT IMMUNOL, V3, P687, DOI 10.1038/ni813
   Prabhakar S, 2012, NEUROL INDIA, V60, P465, DOI 10.4103/0028-3886.103185
   Prasad K, 2012, INDIAN J MED RES, V136, P221
   SCHIFTER T, 1994, J CHILD NEUROL, V9, P155
   Sharma A, 2012, CELL TRANSPLANT, V21, pS79, DOI 10.3727/096368912X633798
   Siniscalco D, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/480289
   Siniscalco D., 2012, J REGEN MED, V1, P1
   Siniscalco D., 2012, AUTISM, V2, P2
   Stigler KA, 2012, PSYCHOPHARMACOLOGY, V223, P237, DOI 10.1007/s00213-012-2711-3
   Sykova E, 2006, CELL MOL NEUROBIOL, V26, P1113, DOI 10.1007/s10571-006-9007-2
   Theoharides TC, 2012, BBA-MOL BASIS DIS, V1822, P34, DOI 10.1016/j.bbadis.2010.12.017
   Theoharides TC, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-168
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Verhoeven JS, 2010, NEURORADIOLOGY, V52, P3, DOI 10.1007/s00234-009-0583-y
   Vojdani A, 2004, NUTR NEUROSCI, V7, P151, DOI 10.1080/10284150400004155
   Zhu B., 2013, CURR OPIN CHEM ENG, V2, P3, DOI 0. 11016/j.coche.2012.11.002.
   Zilbovicius M, 2000, AM J PSYCHIAT, V157, P1988, DOI 10.1176/appi.ajp.157.12.1988
   Zilbovicius M, 2006, REV BRAS PSIQUIATR, V28, pS21, DOI 10.1590/S1516-44462006000500004
NR 60
TC 1
Z9 1
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1687-966X
J9 STEM CELLS INT
JI Stem Cells Int.
PY 2013
DI 10.1155/2013/623875
PG 13
WC Cell & Tissue Engineering
SC Cell Biology
GA 215KB
UT WOS:000324207600001
ER

PT J
AU Cheng, Y
   Corbin, JG
   Levy, RJ
AF Cheng, Ying
   Corbin, Joshua G.
   Levy, Richard J.
TI Programmed Cell Death Is Impaired in the Developing Brain of Fmr1
   Mutants
SO DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Programmed cell death; Apoptosis; Brain; Development; Fragile X
   syndrome; Autism
ID FRAGILE-X-SYNDROME; NERVOUS-SYSTEM; CYTOCHROME-C; MOUSE MODEL; MICE;
   APOPTOSIS; AUTISM; MITOCHONDRIA; PROTEIN; CORTEX
AB Fragile X syndrome (FXS), due to transcriptional silencing of fragile X mental retardation protein (FMRP), is characterized by excess synaptic connections and impaired dendrite maturation. Programmed cell death (PCD) is critical for synaptogenesis and elimination of aberrant neuronal connections in the developing brain; however, the role of FMRP in PCD is unknown. The aim of this work was to assess the intrinsic apoptosis pathway in the developing brain of Fmr1 mutants. To accomplish this, we evaluated two different Fmr1 mutant strains of 10-day-old male mice compared with appropriate controls. We performed immunohistochemistry for activated caspase-3 and TUNEL assays, quantified the number of neurons in neocortex and hippocampus, determined cytochrome c peroxidase activity, measured the amount of cytochrome c release from forebrain mitochondria, and assessed levels of key pro- and antiapoptotic mediators with immunoblot analysis. Both Fmr1 mutant strains demonstrated decreased apoptosis in neocortex, hippocampus, and basolateral amygdala, impaired cytochrome c and procaspase-9 release from mitochondria despite intact Bax translocation, increased expression of the antiapoptotic protein, BCL-xL, and increased number of neurons. Taken together, the data suggest that PCD is impaired due to increased BCL-xL expression and is associated with excess neurons in the developing brain of FMRP-deficient mice. It is possible that deficient PCD prevents neuron elimination and results in abnormal retention of developmentally transient neurons. Thus, defective PCD may contribute to the excess synaptic connections known to exist in Fmr1 mutants and could play a role in the behavioral phenotype of children with FXS. Copyright (C) 2013 S. Karger AG, Basel
C1 [Cheng, Ying; Levy, Richard J.] George Washington Univ, Sch Med & Hlth Sci, Div Anesthesiol & Pain Med, Childrens Natl Med Ctr, Washington, DC 20052 USA.
   [Corbin, Joshua G.] Childrens Natl Med Ctr, Ctr Neurosci Res, Childrens Res Inst, Washington, DC 20010 USA.
RP Levy, RJ (reprint author), Childrens Natl Med Ctr, Div Anesthesiol & Pain Med, 111 Michigan Ave NW, Washington, DC 20010 USA.
EM rlevy@cnmc.org
CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   Brodkin ES, 2008, BEHAV NEUROSCI, V122, P483, DOI 10.1037/0735-7044.122.2.483
   Budimirovic DB, 2011, DEV NEUROSCI-BASEL, V33, P379, DOI 10.1159/000330213
   Bureau I, 2008, J NEUROSCI, V28, P5178, DOI 10.1523/JNEUROSCI.1076-08.2008
   Callan MA, 2010, HUM MOL GENET, V19, P3068, DOI 10.1093/hmg/ddq213
   Chan WY, 2002, ANAT REC, V267, P261, DOI 10.1002/ar.10100
   Cheng Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032029
   Clancy B, 2007, NEUROTOXICOLOGY, V28, P931, DOI 10.1016/j.neuro.2007.01.014
   Comery TA, 1997, P NATL ACAD SCI USA, V94, P5401, DOI 10.1073/pnas.94.10.5401
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638
   el Bekay R, 2007, EUR J NEUROSCI, V26, P3169, DOI 10.1111/j.1460-9568.2007.05939.x
   FERRER I, 1990, NEUROSCI RES, V8, P60, DOI 10.1016/0168-0102(90)90058-M
   FERRER I, 1990, NEUROSCIENCE, V39, P451, DOI 10.1016/0306-4522(90)90281-8
   Franklin KBJ, 1997, MOUSE BRAIN STEREOTA, V1st
   Gatto CL, 2011, DEV BIOL, V356, P291, DOI 10.1016/j.ydbio.2011.05.001
   He LH, 2003, P NATL ACAD SCI USA, V100, P1022, DOI 10.1073/pnas.0333594100
   Hornig M, 2004, MOL PSYCHIATR, V9, P833, DOI 10.1038/sj.mp.4001529
   JACOBS EE, 1960, J BIOL CHEM, V235, P531
   Kim NH, 2004, B KOR CHEM SOC, V25, P1889
   Kim WR, 2011, DEV GROWTH DIFFER, V53, P225, DOI 10.1111/j.1440-169X.2010.01226.x
   Klintsova AY, 2007, ALCOHOL CLIN EXP RES, V31, P2073, DOI 10.1111/j.1530-0277.2007.00528.x
   Kwon MS, 2010, KOREAN J PHYSIOL PHA, V14, P257, DOI 10.4196/kjpp.2010.14.5.257
   Llambi F, 2011, MOL CELL, V44, P517, DOI 10.1016/j.molcel.2011.10.001
   Luscher C, 2010, NEURON, V65, P445, DOI 10.1016/j.neuron.2010.01.016
   Olmos-Serrano JL, 2010, J NEUROSCI, V30, P9929, DOI 10.1523/JNEUROSCI.1714-10.2010
   Olmos-Serrano JL, 2011, DEV NEUROSCI-BASEL, V33, P395, DOI 10.1159/000332884
   OZAWA T, 1980, P NATL ACAD SCI-BIOL, V77, P5084, DOI 10.1073/pnas.77.9.5084
   Paxinos G, 2007, ATLAS DEV MOUSE BRAI
   Precht TA, 2005, CELL DEATH DIFFER, V12, P255, DOI 10.1038/sj.cdd.4401552
   Renault TT, 2013, INT J BIOCHEM CELL B, V45, P64, DOI 10.1016/j.biocel.2012.09.022
   Rice D, 2000, ENVIRON HEALTH PERSP, V108, P511, DOI 10.2307/3454543
   Sanno H, 2010, J NEUROSCI, V30, P4221, DOI 10.1523/JNEUROSCI.3318-09.2010
   Sen P, 2003, MOL CELL BIOCHEM, V253, P241, DOI 10.1023/A:1026020101379
   Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010
   Singh BK, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034200
   Stenqvist A, 2005, EMBO REP, V6, P973, DOI 10.1038/sj.embor.7400512
   Tanaka M, 2002, J BACTERIOL, V184, P840
   Vanderhaeghen P, 2010, CSH PERSPECT BIOL, V2, DOI 10.1101/cshperspect.a001859
   Zang JB, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000758
NR 40
TC 2
Z9 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0378-5866
J9 DEV NEUROSCI-BASEL
JI Dev. Neurosci.
PY 2013
VL 35
IS 4
BP 347
EP 358
DI 10.1159/000353248
PG 12
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 210TH
UT WOS:000323857000007
PM 23900139
ER

PT J
AU Voineagu, I
   Yoo, HJ
AF Voineagu, Irina
   Yoo, Hee Jeong
TI Current Progress and Challenges in the Search for Autism Biomarkers
SO DISEASE MARKERS
LA English
DT Review
ID DE-NOVO MUTATIONS; EARLY BEHAVIORAL INTERVENTION; SPECTRUM DISORDERS;
   GENE-EXPRESSION; OXIDATIVE STRESS; YOUNG-CHILDREN; MITOCHONDRIAL
   DYSFUNCTION; CHROMOSOMAL MICROARRAY; MICROGLIAL ACTIVATION;
   PSYCHIATRIC-DISORDERS
AB Autism spectrum disorders (ASD) encompass a range of neurodevelopmental conditions that are clinically and etiologically very heterogeneous. ASD is currently diagnosed entirely on behavioral criteria, but intensive research efforts are focused on identifying biological markers for disease risk and early diagnosis. Here, we discuss recent progress toward identifying biological markers for ASD and highlight specific challenges as well as ethical aspects of translating ASD biomarker research into the clinic.
C1 [Voineagu, Irina] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia.
   [Yoo, Hee Jeong] Seoul Natl Univ, Dept Psychiat, Bundang Hosp, Gyeonggi 441701, South Korea.
RP Yoo, HJ (reprint author), Seoul Natl Univ, Dept Psychiat, Bundang Hosp, Gyeonggi 441701, South Korea.
EM hjyoo@snu.ac.kr
FU NARSAD; Japanese Society for Promotion of Science; Ministry of Health
   and Welfare, Republic of Korea [A120029]
FX This work was supported by a NARSAD Young Investigator Award (I.
   Voineagu), a grant-in-aid from the Japanese Society for Promotion of
   Science (I. Voineagu), and a Korea Healthcare Technology R&D Project
   (A120029) from the Ministry of Health and Welfare, Republic of Korea (H.
   J. Yoo).
CR Abney M, 2001, AM J HUM GENET, V68, P1302, DOI 10.1086/320112
   Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Anderson Jeffrey S, 2011, Brain, V134, P3742, DOI 10.1093/brain/awr263
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Ashwood P, 2008, J NEUROIMMUNOL, V204, P149, DOI 10.1016/j.jneuroim.2008.07.006
   Association A. P., 2000, DIAGN STAT MAN MENT, VFourth
   Atkinson J, 2001, CLIN PHARMACOL THER, V69, P89
   Austin DW, 2008, J TOXICOL ENV HEAL A, V71, P1349, DOI 10.1080/15287390802271723
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Barnard-Brak L, 2011, PEDIATR NEUROL, V44, P97, DOI 10.1016/j.pediatrneurol.2010.09.011
   Barton M. L., 2013, NEUROSCIENCE AUTISM, P39
   Beaudet AL, 2013, CHILD DEV, V84, P121, DOI 10.1111/cdev.12050
   Ben Itzchak E, 2008, RES DEV DISABIL, V29, P447, DOI 10.1016/j.ridd.2007.08.003
   Bosl W, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-18
   Boulanger LM, 2009, NEURON, V64, P93, DOI 10.1016/j.neuron.2009.09.001
   Brun CC, 2009, HUM BRAIN MAPP, V30, P3887, DOI 10.1002/hbm.20814
   Cantor RM, 2009, CURR PSYCHIAT REP, V11, P137
   Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099
   Center for Disease Control, 2010, PUBL HLTH GEN GEN TE
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Connolly AM, 2006, BIOL PSYCHIAT, V59, P354, DOI 10.1016/j.biopsych.2005.07.004
   Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005
   Correia C, 2006, J AUTISM DEV DISORD, V36, P1137, DOI 10.1007/s10803-006-0138-6
   Croonenberghs J, 2002, PSYCHOL MED, V32, P1457, DOI 10.1017/S0033291702006037
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
   Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
   Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
   Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010
   Ecker C, 2013, MOL PSYCHIATR, V18, P435, DOI 10.1038/mp.2012.102
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Enstrom AM, 2009, BRAIN BEHAV IMMUN, V23, P124, DOI 10.1016/j.bbi.2008.08.001
   Froehlich W., 2013, J AUTISM DEV DISORDE
   Frustaci A, 2012, FREE RADICAL BIO MED, V52, P2128, DOI 10.1016/j.freeradbiomed.2012.03.011
   Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012
   Glatt SJ, 2012, J AM ACAD CHILD PSY, V51, P934, DOI [10.1016/j.jaac.2012.07.007, 10.1016/j.jaac.2011.07.007]
   Goines P, 2011, BRAIN BEHAV IMMUN, V25, P514, DOI 10.1016/j.bbi.2010.11.017
   Gregg JP, 2008, GENOMICS, V91, P22, DOI 10.1016/j.ygeno.2007.09.003
   Griffin R., 2011, BMC MED, V9
   Grigorenko EL, 2008, PEDIATRICS, V122, pE438, DOI 10.1542/peds.2007-3604
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Heil K. M., 2013, CURRENT PSYCHIAT REP, V15
   Heyer NJ, 2012, AUTISM RES, V5, P84, DOI 10.1002/aur.236
   Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118
   Hu VW, 2009, AUTISM RES, V2, P67, DOI 10.1002/aur.72
   Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775
   Hu VW, 2012, DIS MARKERS, V33, P277, DOI 10.3233/DMA-2012-0916
   Hubl D, 2003, NEUROLOGY, V61, P1232
   Ingalhalikar M, 2011, NEUROIMAGE, V57, P918, DOI 10.1016/j.neuroimage.2011.05.023
   James SJ, 2004, AM J CLIN NUTR, V80, P1611
   James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366
   Jiao Y, 2011, ADV MED SCI-POLAND, V56, P334, DOI 10.2478/v10039-011-0042-y
   Jordan BR, 2010, J MED ETHICS, V36, P440, DOI 10.1136/jme.2009.031385
   Kanner L, 1943, NERV CHILD, V2, P217
   KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100
   Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052
   Kim S. H., 2013, NEUROSCIENCE AUTISM, P25
   Kong SW, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049475
   Lange N, 2010, AUTISM RES, V3, P350, DOI 10.1002/aur.162
   Lattin J.M., 2003, ANAL MULTIVARIATE DA
   Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
   Lintas C, 2012, NEUROBIOL DIS, V45, P57, DOI 10.1016/j.nbd.2010.11.010
   Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
   McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   Minshew NJ, 2010, CURR OPIN NEUROL, V23, P124, DOI 10.1097/WCO.0b013e32833782d4
   Molloy CA, 2006, J NEUROIMMUNOL, V172, P198, DOI 10.1016/j.jneuroim.2005.11.007
   Momeni N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.19
   Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069
   Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
   Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   Okada K, 2007, PROG NEURO-PSYCHOPH, V31, P187, DOI 10.1016/j.pnpbp.2006.08.020
   Oliveira G, 2005, DEV MED CHILD NEUROL, V47, P185, DOI 10.1017/S0012162205000332
   Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   Palmen SJMC, 2005, PSYCHOL MED, V35, P561, DOI 10.1017/S0033291704003496
   Pelphrey KA, 2007, SOC COGN AFFECT NEUR, V2, P140, DOI 10.1093/scan/nsm010
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059
   Ratajczak HV, 2011, J IMMUNOTOXICOL, V8, P80, DOI 10.3109/1547691X.2010.538749
   Redcay E, 2008, BIOL PSYCHIAT, V64, P589, DOI 10.1016/j.biopsych.2008.05.020
   Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Rommelse NNJ, 2011, J AUTISM DEV DISORD, V41, P44, DOI 10.1007/s10803-010-1026-7
   Rose S, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.61
   Rossi CC, 2011, BRAIN BEHAV IMMUN, V25, P1123, DOI 10.1016/j.bbi.2011.02.011
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P389, DOI 10.1038/mp.2011.165
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8
   Scherer SW, 2011, HUM GENET, V130, P123, DOI 10.1007/s00439-011-1037-2
   Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
   Schwarz E, 2011, MOL PSYCHIATR, V16, P1213, DOI 10.1038/mp.2010.102
   Skafidas E., 2012, MOL PSYCHIAT
   Skuse DH, 2012, J AM ACAD CHILD PSY, V51, P344, DOI 10.1016/j.jaac.2012.02.009
   Smith S. E. P., 2011, SCI TRANSLATIONAL ME, V3
   State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x
   Stigler K. A., 2013, NEUROSCIENCE AUTISM, P251
   Suzuki K, 2013, JAMA PSYCHIAT, V70, P49, DOI 10.1001/jamapsychiatry.2013.272
   Theoharides T. C., 2013, J NEUROINFLAMMATION, V10
   Uddin LQ, 2011, BIOL PSYCHIAT, V70, P833, DOI 10.1016/j.biopsych.2011.07.014
   van Daalen E, 2007, PEDIATR NEUROL, V37, P324, DOI 10.1016/j.pediatrneurol.2007.06.006
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Voineagu I, 2012, NEUROBIOL DIS, V45, P69, DOI 10.1016/j.nbd.2011.07.017
   Walsh P, 2011, NAT REV NEUROSCI, V12, P603, DOI 10.1038/nrn3113
   Webb SJ, 2006, J AUTISM DEV DISORD, V36, P881, DOI 10.1007/s10803-006-0126-x
   Weiss LA, 2005, AM J HUM GENET, V76, P33, DOI 10.1086/426697
   Weissman JR, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003815
   Werling DM, 2013, CURR OPIN NEUROL, V26, P146, DOI 10.1097/WCO.0b013e32835ee548
   Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005
   Wills S, 2009, BRAIN BEHAV IMMUN, V23, P64, DOI 10.1016/j.bbi.2008.07.007
   Wills S, 2007, ANN NY ACAD SCI, V1107, P79, DOI 10.1196/annals.1381.009
   Woods JS, 2010, ENVIRON HEALTH PERSP, V118, P1450, DOI 10.1289/ehp.0901713
   Yap IKS, 2010, J PROTEOME RES, V9, P2996, DOI 10.1021/pr901188e
   Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
NR 121
TC 0
Z9 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 0278-0240
J9 DIS MARKERS
JI Dis. Markers
PY 2013
BP 55
EP 65
DI 10.1155/2013/476276
PG 11
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 212LZ
UT WOS:000323986200001
PM 24167349
ER

PT J
AU Masri, AT
   Al Suluh, N
   Nasir, R
AF Masri, Amira T.
   Al Suluh, Najati
   Nasir, Ramzi
TI Diagnostic delay of autism in Jordan: review of 84 cases
SO LIBYAN JOURNAL OF MEDICINE
LA English
DT Letter
ID DISORDERS; CHILDREN; PROFILE
C1 [Masri, Amira T.; Al Suluh, Najati] Univ Jordan, Div Child Neurol, Dept Pediat, Fac Med, Amman, Jordan.
   [Nasir, Ramzi] Harvard Univ, Sch Med, Dept Dev Behav Pediat, Boston Childrens Hosp, Boston, MA USA.
RP Masri, AT (reprint author), Univ Jordan, Div Child Neurol, Dept Pediat, Fac Med, Amman, Jordan.
EM masriamira69@hotmail.com
CR Afifi M. M., 2005, Eastern Mediterranean Health Journal, V11, P319
   Al-Farsi YM, 2011, J AUTISM DEV DISORD, V41, P821, DOI 10.1007/s10803-010-1094-8
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT, P69
   Eapen V, 2007, J TROP PEDIATRICS, V53, P202, DOI 10.1093/tropej/fml091
   Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239
   Hamamy HA, 2007, SAUDI MED J, V28, P1015
   Kalra Veena, 2005, Indian Journal of Pediatrics, V72, P227, DOI 10.1007/BF02859263
   Masri A, 2011, BRAIN DEV-JPN, V33, P810, DOI 10.1016/j.braindev.2010.12.002
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   Samadi S. A., 2011, AUTISM RES TREAT, DOI [10.1155/2011/145359, DOI 10.1155/2011/145359]
   Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
   Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050
NR 12
TC 0
Z9 0
PU CO-ACTION PUBLISHING
PI JARFALLA
PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN
SN 1993-2820
J9 LIBYAN J MED
JI Libyan J. Med.
PY 2013
VL 8
AR 21725
DI 10.3402/ljm.v8i0.21725
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 208SM
UT WOS:000323699800001
PM 23962635
ER

PT J
AU Pino-Lopez, M
   Romero-Ayuso, DM
AF Pino-Lopez, Manuel
   Romero-Ayuso, Dulce M.
TI Autism Spectrum Disorders and Parental Occupational Exposures
SO REVISTA ESPANOLA DE SALUD PUBLICA
LA Spanish
DT Article
DE Environment; Autism; Electromagnetic Fields; Occupational Exposure;
   Genetics; Early Intervention; Solvents; Night Work
ID BREAST-CANCER; ELECTROMAGNETIC-RADIATION; ORGANIC-SOLVENTS;
   UNITED-STATES; RISK; CHILDREN; CELLS; NIGHT; MECHANISMS; TOXICITY
AB Background: Studies of siblings and twins suggest a genetic component of autism that does not fully explain its current increase. The aim is to investigate whether environmental factors such as exposure to occupational hazards (night work, handling of solvents and/or electromagnetic fields) increases the likelihood of autism spectrum disorders (ASD) in children.
   Methods: Observational case control study by analyzing the records of 206 children (age between 16 and 36 months) evaluated in the Early Intervention Service of Ciudad Real (70 with ASD and 136 unaffected children). To assess the risk of ASD associated with night work, handling of solvents and/or electromagnetic fields, odds ratio (OR) were calculated with 95% confidence intervals (CI).
   Results: The risk of ASD is multiplied by 2.22 when one parent works in the studied occupations (OR=2.22, 95% CI=1.42-3.48), high-lighting work with solvents (OR=2.81, 95% CI=1.28-6.17) and night work (OR=2.18, 95% CI=1.21-3.93). It is multiplied by 3 if the mother's job is one of these occupations (OR=3, 95% CI=1.44-6.26), standing out night work (OR=3.47, 95% CI=1.39-8.63), and handling of solvents (OR=2.88, 95% CI=1.28-6.17); whereas it is multiplied by 1.94 if the father works in these occupations (OR=1.94, 95% CI=1.07-3.53), standing out handling of solvents (OR=2.81, 95% CI=1.01-7.86). A positive association between the educational level of parents and ASD is found.
   Conclusions: The results show a significant relationship between the exposure of the parents to occupational hazards and ASD in the children, suggesting the involvement of genetic alterations caused by environmental factors in the origin of the disorder.
C1 [Pino-Lopez, Manuel] Consejeria Sanidad & Asuntos Sociales Junta Comun, Ctr Base Atenc Personas Con Discapacidad Ciudad R, Ciudad Real, Spain.
   [Romero-Ayuso, Dulce M.] Univ Castilla La Mancha, Fac Terapia Ocupac Logopedia & Enfermeria, Dept Psicol, E-13071 Ciudad Real, Spain.
RP Pino-Lopez, M (reprint author), C Zancara 27, Ciudad Real 13002, Spain.
EM manuelpino.6@gmail.com
CR Alter MD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016715
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Artigas-Pallares J, 2010, REV NEUROL, V50, P591
   Bertrand J, 2001, PEDIATRICS, V108, P1155, DOI 10.1542/peds.108.5.1155
   Blask DE, 2011, J PINEAL RES, V51, P259, DOI 10.1111/j.1600-079X.2011.00888.x
   Cassini C, 2011, INT J OCCUP MED ENV, V24, P308, DOI 10.2478/s13382-011-0030-2
   Centers for Disease Control and Prevention, 2012, MORBIDITY MORTALITY
   Chia SE, 2002, OCCUP ENVIRON MED, V59, P149, DOI 10.1136/oem.59.3.149
   Colt JS, 1998, ENVIRON HEALTH PERSP, V106, P909, DOI 10.2307/3434208
   Cordier S, 2008, BASIC CLIN PHARMACOL, V102, P176, DOI 10.1111/j.1742-7843.2007.00162.x
   Costa G, 1996, APPL ERGON, V27, P9, DOI 10.1016/0003-6870(95)00047-X
   Durkin MS, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011551
   Fritschi L, 2011, MED HYPOTHESES, V77, P430, DOI 10.1016/j.mehy.2011.06.002
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   Hooiveld M, 2006, OCCUP ENVIRON MED, V63, P538, DOI 10.1136/oem.2005.026013
   Julvezi J, 2009, IND HEALTH, V47, P459, DOI 10.2486/indhealth.47.459
   Kane RC, 2004, MED HYPOTHESES, V62, P195, DOI 10.1016/S0306/9877(03)00309-8
   Kinney DK, 2009, MED HYPOTHESES, V74, P102
   Lai H, 2004, ENVIRON HEALTH PERSP, V112, P687, DOI 10.1289/ehp.6355
   Laslo-Baker D, 2004, ARCH PEDIAT ADOL MED, V158, P956, DOI 10.1001/archpedi.158.10.956
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Lindbohm ML, 2009, INT J CANCER, V124, P2954, DOI 10.1002/ijc.24309
   LOOMIS DP, 1994, J NATL CANCER I, V86, P921, DOI 10.1093/jnci/86.12.921
   Mattison DR, 2010, CURR OPIN PEDIATR, V22, P208, DOI 10.1097/MOP.0b013e32833779bf
   Mazur-Kolecka B, 2009, NEUROTOX RES, V16, P87, DOI 10.1007/s12640-009-9052-y
   McCanlies EC, 2012, J AUTISM DEV DISORD, V42, P2323, DOI 10.1007/s10803-012-1468-1
   Ministerio de Economia y Hacienda, 2010, B OFICIAL ESTADO, V306
   Muhle R., 2004, PEDIATRICS, V113, P472
   Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Robins DL, 2008, AUTISM, V12, P537, DOI 10.1177/1362361308094502
   Schanen NC, 2006, HUM MOL GENET, V15, P138, DOI DOI 10.1093/HMG/DDL213
   Schernhammer ES, 2011, AM J OBSTET GYNECOL, V205, p476e1
   Schernhammer ES, 2001, J NATL CANCER I, V93, P1563
   Sharifian Akbar, 2005, J Circadian Rhythms, V3, P15, DOI 10.1186/1740-3391-3-15
   Silva CLM, 2007, BRIT J PHARMACOL, V151, P195, DOI 10.1038/sj.bjp.0707225
   Smulevich VB, 1999, INT J CANCER, V83, P718, DOI 10.1002/(SICI)1097-0215(19991210)83:6<718::AID-IJC3>3.0.CO;2-T
   Tamura H, 2008, J PINEAL RES, V44, P280, DOI [10.1111/j.1600-079X.2007.00524.x, 10.1111/j.1600-079X.2007.00524.X]
   Thornton IM, 2006, MED HYPOTHESES, V67, P378, DOI 10.1016/j.mehy.2006.01.032
   Yama B, 2012, J AUTISM DEV DISORD, V42, P23, DOI 10.1007/s10803-011-1211-3
NR 40
TC 1
Z9 2
PU MINISTERIO DE SANIDAD Y CONSUMO
PI MADRID
PA PASEO DEL PRADO 18-20, MADRID, 28071, SPAIN
SN 1135-5727
J9 REV ESP SALUD PUBLIC
JI Rev. Esp. Salud Publica
PD JAN-FEB
PY 2013
VL 87
IS 1
BP 73
EP 85
PG 13
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 195YM
UT WOS:000322739800008
PM 23748659
ER

PT J
AU Deriziotis, P
   Fisher, SE
AF Deriziotis, Pelagia
   Fisher, Simon E.
TI Neurogenomics of speech and language disorders: the road ahead
SO GENOME BIOLOGY
LA English
DT Review
DE exome; genome; FOXP2; functional validation; language; next-generation
   sequencing; neurodevelopmental disorders; speech
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; SHORT-TERM-MEMORY;
   MENTAL-RETARDATION; CHILDHOOD-APRAXIA; INHERITED SPEECH; FOXP2
   EXPRESSION; INTELLECTUAL DISABILITY; DEVELOPMENTAL SPEECH;
   SUSCEPTIBILITY GENE
AB Next-generation sequencing is set to transform the discovery of genes underlying neurodevelopmental disorders, and so off er important in sights into the biological bases of spoken language. Success will depend on functional assessments in neuronal cell lines, animal models and humans themselves.
C1 [Deriziotis, Pelagia; Fisher, Simon E.] Max Planck Inst Psycholinguist, NL-6525 XD Nijmegen, Netherlands.
   [Fisher, Simon E.] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 EN Nijmegen, Netherlands.
RP Fisher, SE (reprint author), Max Planck Inst Psycholinguist, Wundtlaan 1, NL-6525 XD Nijmegen, Netherlands.
EM simon.fisher@mpi.nl
RI Fisher, Simon/E-9130-2012; Derizioti, Pelagia/C-3857-2015
OI Fisher, Simon/0000-0002-3132-1996; Derizioti,
   Pelagia/0000-0001-5544-8345
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
   Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005
   Alcock KJ, 2000, BRAIN LANG, V75, P17, DOI 10.1006/brln.2000.2322
   Anderson GR, 2012, P NATL ACAD SCI USA, V109, P18120, DOI 10.1073/pnas.1216398109
   Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015
   Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
   Barry JG, 2007, GENES BRAIN BEHAV, V6, P66, DOI 10.1111/j.1601-183X.2006.00232.x
   Bartlett CW, 2002, AM J HUM GENET, V71, P45, DOI 10.1086/341095
   Bartlett CW, 2004, HUM HERED, V57, P10, DOI 10.1159/000077385
   Belton E, 2003, HUM BRAIN MAPP, V18, P194, DOI 10.1002/hbm.10093
   Dunham I, 2012, NATURE, V489, P57, DOI 10.1038/nature11247
   Bishop D, 2009, ANN NY ACAD SCI, V1156, P1, DOI 10.1111/j.1749-6632.2009.04419.x
   Bishop DVM, 2010, BEHAV GENET, V40, P618, DOI 10.1007/s10519-010-9381-x
   Bishop DVM, 2008, GENES BRAIN BEHAV, V7, P365, DOI 10.1111/j.1601-183X.2007.00360.x
   BISHOP DVM, 1995, DEV MED CHILD NEUROL, V37, P56
   Bishop DVM, 2001, PHILOS T R SOC B, V356, P369, DOI 10.1098/rstb.2000.0770
   Boyle AP, 2012, GENOME RES, V22, P1790, DOI 10.1101/gr.137323.112
   Buxbaum JD, 2012, NEURON, V76, P1052, DOI 10.1016/j.neuron.2012.12.008
   Newbury DF, 2004, AM J HUM GENET, V74, P1225
   Cooper GM, 2011, NAT REV GENET, V12, P628, DOI 10.1038/nrg3046
   Dennis Emily L, 2011, Brain Connect, V1, P447, DOI 10.1089/brain.2011.0064
   Drayna D, 2011, J NEURODEV DISORD, V3, P374, DOI 10.1007/s11689-011-9090-7
   Enard W, 2002, NATURE, V418, P869, DOI 10.1038/nature01025
   Enard W, 2011, CURR OPIN NEUROBIOL, V21, P415, DOI 10.1016/j.conb.2011.04.008
   Falcaro M, 2008, GENES BRAIN BEHAV, V7, P393, DOI 10.1111/j.1601-183X.2007.00364.x
   Falivelli G, 2012, HUM MOL GENET, V21, P4761, DOI 10.1093/hmg/dds320
   Ferland RJ, 2003, J COMP NEUROL, V460, P266, DOI 10.1002/cne.10654
   Fisher SE, 2003, ANNU REV NEUROSCI, V26, P57, DOI 10.1146/annurev.neuro.26.041002.131144
   Fisher SE, 1998, NAT GENET, V18, P168, DOI 10.1038/ng0298-168
   Fisher SE, 2009, TRENDS GENET, V25, P166, DOI 10.1016/j.tig.2009.03.002
   Fisher SE, 2006, NAT REV GENET, V7, P9, DOI 10.1038/nrg1747
   Fisher SE, 2002, NAT REV NEUROSCI, V3, P767, DOI 10.1038/nrn936
   Fowler DM, 2010, NAT METHODS, V7, P741, DOI 10.1038/nmeth.1492
   French CA, 2012, MOL PSYCHIATR, V17, P1077, DOI 10.1038/mp.2011.105
   Friedman JI, 2008, MOL PSYCHIATR, V13, P261, DOI 10.1038/sj.mp.4002049
   Gilissen C, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-9-228
   Graham SA, 2013, CURR OPIN NEUROBIOL, V23, P43, DOI 10.1016/j.conb.2012.11.006
   Green RE, 2010, SCIENCE, V328, P710, DOI 10.1126/science.1188021
   Gregor A, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-106
   Groszer M, 2008, CURR BIOL, V18, P354, DOI 10.1016/j.cub.2008.01.060
   Haesler S, 2004, J NEUROSCI, V24, P3164, DOI 10.1523/JNEUROSCI.4369-03.2004
   Haesler S, 2007, PLOS BIOL, V5, P2885, DOI 10.1371/journal.pbio.0050321
   Hamdan FF, 2010, AM J HUM GENET, V87, P671, DOI 10.1016/j.ajhg.2010.09.017
   Hoischen A, 2011, NAT GENET, V43, P729, DOI 10.1038/ng.868
   Hoischen A, 2010, NAT GENET, V42, P483, DOI 10.1038/ng.581
   Horn D, 2010, HUM MUTAT, V31, pE1851, DOI 10.1002/humu.21362
   Collins FS, 2004, NATURE, V431, P931, DOI 10.1038/nature03001
   Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009
   Kamal M, 2009, MOL IMMUNOL, V46, P991, DOI 10.1016/j.molimm.2008.09.034
   Kang C, 2010, NEW ENGL J MED, V362, P677, DOI 10.1056/NEJMoa0902630
   Kang CS, 2011, ANNU REV GENOM HUM G, V12, P145, DOI 10.1146/annurev-genom-090810-183119
   Kos M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046995
   Kurt S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033130
   Kurt S, 2009, BRAIN RES, V1289, P30, DOI 10.1016/j.brainres.2009.06.092
   Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076
   Lai CSL, 2003, BRAIN, V126, P2455, DOI 10.1093/brain/awg247
   Lai CSL, 2000, AM J HUM GENET, V67, P357, DOI 10.1086/303011
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   Lee WS, 2011, J BIOL CHEM, V286, P39786, DOI 10.1074/jbc.M111.295899
   LEWIS BA, 1992, J SPEECH HEAR RES, V35, P1086
   Lewis BA, 2007, AM J SPEECH-LANG PAT, V16, P108, DOI 10.1044/1058-0360(2007/015)
   Li SR, 2004, MOL CELL BIOL, V24, P809, DOI 10.1128/MCB.24.2.809-822.2004
   Liegeois F, 2003, NAT NEUROSCI, V6, P1230, DOI 10.1038/nn1138
   Lim ET, 2013, NEURON, V77, P235, DOI 10.1016/j.neuron.2012.12.029
   MacDermot KD, 2005, AM J HUM GENET, V76, P1074, DOI 10.1086/430841
   Maricic T, 2012, MOL BIOL EVOL, V30, P844, DOI DOI 10.1093/MOLBEV/MSS271
   Marseglia G, 2012, EUR J MED GENET, V55, P216, DOI 10.1016/j.ejmg.2012.01.005
   Meyer M, 2012, SCIENCE, V338, P222, DOI 10.1126/science.1224344
   Miller JE, 2008, J NEUROPHYSIOL, V100, P2015, DOI 10.1152/jn.90415.2008
   Monaco AP, 2007, ANN HUM GENET, V71, P660, DOI 10.1111/j.1469-1809.2007.00361.x
   Mukamel Z, 2011, J NEUROSCI, V31, P11437, DOI 10.1523/JNEUROSCI.0181-11.2011
   Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011
   NEILS J, 1986, PERCEPT MOTOR SKILL, V63, P655
   Newbury D. F., 2012, EUR J HUM GENET, V21, P361
   Newbury DF, 2010, NEURON, V68, P309, DOI 10.1016/j.neuron.2010.10.001
   Newbury DF, 2002, AM J HUM GENET, V70, P1318, DOI 10.1086/339931
   Newbury DF, 2011, BEHAV GENET, V41, P90, DOI 10.1007/s10519-010-9424-3
   Newbury DF, 2009, AM J HUM GENET, V85, P264, DOI 10.1016/j.ajhg.2009.07.004
   Newbury DF, 2005, TRENDS COGN SCI, V9, P528, DOI 10.1016/j.tics.2005.09.002
   Ng PC, 2003, NUCLEIC ACIDS RES, V31, P3812, DOI 10.1093/nar/gkg509
   Ng SB, 2010, NAT GENET, V42, P790, DOI 10.1038/ng.646
   Nippold MA, 2012, AM J SPEECH-LANG PAT, V21, P183, DOI 10.1044/1058-0360(2012/11-0078)
   Oakley K, 2012, BLOOD, V119, P6099, DOI 10.1182/blood-2011-10-388710
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Pal DK, 2011, CURR OPIN NEUROL, V24, P126, DOI 10.1097/WCO.0b013e328344634a
   Patwardhan RP, 2012, NAT BIOTECHNOL, V30, P265, DOI 10.1038/nbt.2136
   Patwardhan RP, 2009, NAT BIOTECHNOL, V27, P1173, DOI 10.1038/nbt.1589
   PINKER S, 1990, BEHAV BRAIN SCI, V13, P707
   Pitt JN, 2010, SCIENCE, V330, P376, DOI 10.1126/science.1192001
   Poliak S, 2003, J CELL BIOL, V162, P1149, DOI 10.1083/jcb.200305018
   Prasse JE, 2008, AM FAM PHYSICIAN, V77, P1271
   Raca G, 2013, EUR J HUM GENET, V21, P455, DOI 10.1038/ejhg.2012.165
   Raskind Wendy H, 2012, Front Psychol, V3, P601, DOI 10.3389/fpsyg.2012.00601
   Raza MH, 2012, HUM GENET, V132, P385
   Raza MH, 2012, HUM GENET, V131, P311, DOI 10.1007/s00439-011-1134-2
   Riaz N, 2005, AM J HUM GENET, V76, P647, DOI 10.1086/429226
   Roll P, 2010, HUM MOL GENET, V19, P4848, DOI 10.1093/hmg/ddq415
   Ruzzo EK, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-3-150
   Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945
   Scharff C, 2013, CURR OPIN NEUROBIOL, V23, P29, DOI 10.1016/j.conb.2012.10.001
   Schulz SB, 2010, GENES BRAIN BEHAV, V9, P732, DOI 10.1111/j.1601-183X.2010.00607.x
   Shriberg LD, 2011, J SPEECH LANG HEAR R, V54, P487, DOI 10.1044/1092-4388(2010/10-0068)
   Shriberg LD, 2008, AM J MED GENET A, V146A, P2227, DOI 10.1002/ajmg.a.32363
   Shu WG, 2007, DEVELOPMENT, V134, P1991, DOI 10.1242/dev.02846
   Shu WG, 2001, J BIOL CHEM, V276, P27488, DOI 10.1074/jbc.M100636200
   Sirmaci A, 2011, AM J HUM GENET, V89, P289, DOI 10.1016/j.ajhg.2011.06.007
   Newbury DF, 2002, AM J HUM GENET, V70, P384
   Spiteri E, 2007, AM J HUM GENET, V81, P1144, DOI 10.1086/522237
   Stein MB, 2011, BIOL PSYCHIAT, V69, P825, DOI 10.1016/j.biopsych.2010.11.008
   Strauss KA, 2006, NEW ENGL J MED, V354, P1370, DOI 10.1056/NEJMoa052773
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Teramitsu I, 2006, J NEUROSCI, V26, P7390, DOI 10.1523/JNEUROSCI.1662-06.2006
   Teramitsu I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008548
   Teramitsu I, 2004, J NEUROSCI, V24, P3152, DOI 10.1523/JNEUROSCI.5589-03.2004
   Thevenon J, 2013, EUR J HUM GENET, V21, P82, DOI 10.1038/ejhg.2012.116
   TOMBLIN JB, 1989, J SPEECH HEAR DISORD, V54, P287
   Tomblin JB, 1997, J SPEECH LANG HEAR R, V40, P1245
   Tomblin JB, 1998, J SPEECH LANG HEAR R, V41, P188
   Van der Aa N, 2009, EUR J MED GENET, V52, P94, DOI 10.1016/j.ejmg.2009.02.006
   Veltman JA, 2012, NAT REV GENET, V13, P565, DOI 10.1038/nrg3241
   Verkerk AJMH, 2003, GENOMICS, V82, P1, DOI 10.1016/S0888-7543(03)00097-1
   Vernes SC, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002145
   Vernes SC, 2009, EUR J HUM GENET, V17, P1354, DOI 10.1038/ejhg.2009.43
   Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
   Vernes SC, 2007, AM J HUM GENET, V81, P1232, DOI 10.1086/522238
   Vernes SC, 2006, HUM MOL GENET, V15, P3154, DOI 10.1093/hmg/ddl392
   Villanueva P, 2008, REV MED CHILE, V136, P186, DOI [/S0034-98872008000200007, 10.4067/S0034-98872008000200007]
   Villanueva P, 2011, EUR J HUM GENET, V19, P687, DOI 10.1038/ejhg.2010.251
   Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
   Walker RM, 2012, HUM MOL GENET, V21, P2862, DOI 10.1093/hmg/dds111
   Wang Y, 2002, P NATL ACAD SCI USA, V99, P14464, DOI 10.1073/pnas.182532999
   Watkins KE, 2002, BRAIN, V125, P452, DOI 10.1093/brain/awf058
   Watkins KE, 2002, BRAIN, V125, P465, DOI 10.1093/brain/awf057
   Whalley HC, 2011, AM J MED GENET B, V156B, P941, DOI 10.1002/ajmg.b.31241
   White SA, 2006, J NEUROSCI, V26, P10376, DOI 10.1523/JNEUROSCI.3379-06.2006
   Whitehouse AJO, 2011, GENES BRAIN BEHAV, V10, P451, DOI 10.1111/j.1601-183X.2011.00684.x
   Xiang MH, 2005, J BIOL CHEM, V280, P11608, DOI 10.1074/jbc.M413116200
   Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002
   Zweier C, 2009, AM J HUM GENET, V85, P655, DOI 10.1016/j.ajhg.2009.10.004
NR 140
TC 8
Z9 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1465-6906
J9 GENOME BIOL
JI Genome Biol.
PY 2013
VL 14
IS 4
AR 204
DI 10.1186/gb-2013-14-4-204
PG 12
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 192XN
UT WOS:000322521300015
PM 23597266
ER

PT J
AU Dickerson, P
   Robins, B
   Dautenhahn, K
AF Dickerson, Paul
   Robins, Ben
   Dautenhahn, Kerstin
TI Where the action is A conversation analytic perspective on interaction
   between a humanoid robot, a co-present adult and a child with an ASD
SO INTERACTION STUDIES
LA English
DT Article
DE autism; assessment; autistic spectrum disorder; experiment; conversation
   analysis; interaction; humanoid robot; sequences; sequence of
   interaction; socio-emotional reciprocity
ID ASPERGER-SYNDROME; AUTISM; SPECTRUM; RECOGNITION; ATTENTION; TASK; MIND
AB This paper examines interaction involving a child with an Autistic Spectrum Disorder, a humanoid robot and a co-present adult. In this paper data from one child (collected as part of the ROBOSKIN project) is analysed in order to evaluate the potential contributions of a conversation analytic perspective to the examination of data relating to socio-emotional reciprocity. The paper argues for the value of treating all interaction as potentially relevant, looking without carefully pre-defined target behaviours and examining behaviour within its specific sequence of interaction. Adopting this approach, the paper suggests, enables noticings and observations that might not be available from perspectives that rely on the coding of pre-specified behaviours in isolation. Treating all interaction as potentially relevant brought into view interactions that might otherwise be dismissed or ignored - because they occurred before, or after, the trial itself. Being informed by the value of unmotivated looking - rather than pre-specified coding schemes - enabled highly relevant behaviour that was not anticipated within the trials to be analysed. Finally, seeing sequence as important meant that behaviours were appreciated in their intricate detail, enabling a more precise understanding than might be available if they were considered separately from that sequential environment.
C1 [Dickerson, Paul] Univ Roehampton, Whitelands Coll, Dept Psychol, London SW14 4JD, England.
   [Robins, Ben; Dautenhahn, Kerstin] Univ Hertfordshire, Sch Comp Sci, Adapt Syst Res Grp, Hatfield AL10 9AB, Herts, England.
RP Dickerson, P (reprint author), Univ Roehampton, Whitelands Coll, Dept Psychol, Holybourne Ave, London SW14 4JD, England.
EM P.Dickerson@roehampton.ac.uk; b.robins@herts.ac.uk;
   k.dautenhahn@herts.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
   Boraston Z, 2007, NEUROPSYCHOLOGIA, V45, P1501, DOI 10.1016/j.neuropsychologia.2006.11.010
   Dautenhahn Kerstin, 2009, Applied Bionics and Biomechanics, V6, DOI 10.1080/11762320903123567
   Dickerson P., 2007, GESTURE, V7, P271, DOI 10.1075/gest.7.3.02dic
   Frith U., 1994, SOCIAL DEV, V3, P108, DOI DOI 10.1111/J.1467-9507.1994.TB00031.X
   Gliga T, 2012, CHILD DEV, V83, P926, DOI 10.1111/j.1467-8624.2012.01750.x
   Goodwin C., 2003, CONVERSATION BRAIN D
   Haakana M, 2010, J PRAGMATICS, V42, P1499, DOI 10.1016/j.pragma.2010.01.010
   HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x
   Jefferson Gail, 2004, CONVERSATION ANAL ST, P13
   Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0
   Lesh N., 2004, INT US INT IUI 04 MA
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489
   Robins B, 2012, INTERACT STUD, V13, P189, DOI 10.1075/is.13.2.03rob
   Robins B., 2009, P 2 INT C ADV COMP H
   Robins B, 2004, INTERACT STUD, V5, P161, DOI 10.1075/is.5.2.02rob
   SACKS H, 1974, LANGUAGE, V50, P696, DOI 10.2307/412243
   Sacks Harvey, 1984, STRUCTURES SOCIAL AC, P21
   Schegloff E.A., 2007, SEQUENCE ORG INTERAC, V1
   Schegloff Emanuel A, 2003, CONVERSATION BRAIN D, P21
   Shamay-Tsoory SG, 2008, J AUTISM DEV DISORD, V38, P1451, DOI 10.1007/s10803-007-0515-9
   Stribling P., 2005, ISSUES APPL LINGUIST, V15, P3
   Stribling P, 2007, INT J LANG COMM DIS, V42, P427, DOI 10.1080/13682820601183659
   Stribling P, 2009, CLIN LINGUIST PHONET, V23, P555, DOI 10.1080/02699200802491165
   Tarplee C, 1999, CLIN LINGUIST PHONET, V13, P449
NR 27
TC 1
Z9 1
PU JOHN BENJAMINS PUBLISHING COMPANY
PI AMSTERDAM
PA PO BOX 36224, 1020 ME AMSTERDAM, NETHERLANDS
SN 1572-0373
J9 INTERACT STUD
JI Interact. Stud.
PY 2013
VL 14
IS 2
BP 297
EP 316
DI 10.1075/is.14.2.07dic
PG 20
WC Communication; Linguistics
SC Communication; Linguistics
GA 190UL
UT WOS:000322366500008
ER

PT J
AU Tabuchi, K
   Chang, WH
   Nur Farehan, AM
   Thomas, SC
   Shigemoto, R
AF Tabuchi, Katsuhiko
   Chang Wen Hsin
   Nur Farehan, Asgar Mohamed
   Thomas, Sudhof C.
   Shigemoto, Ryuichi
TI Synapse maturation and autism : The role of synapse adhesion molecules
SO JOURNAL OF PHYSIOLOGICAL SCIENCES
LA English
DT Meeting Abstract
C1 [Tabuchi, Katsuhiko] Shinshu Univ, Sch Med, Dept Neurophysiol, Matsumoto, Nagano 390, Japan.
   [Tabuchi, Katsuhiko] PRESTO JST, Okazaki, Aichi, Japan.
   [Tabuchi, Katsuhiko; Chang Wen Hsin; Nur Farehan, Asgar Mohamed; Shigemoto, Ryuichi] Natl Inst Physiol Sci, Okazaki, Aichi 444, Japan.
   [Shigemoto, Ryuichi] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
NR 0
TC 0
Z9 0
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 1880-6546
J9 J PHYSIOL SCI
JI J. Physiol. Sci.
PY 2013
VL 63
SU 1
BP S29
EP S29
PG 1
WC Physiology
SC Physiology
GA 190PH
UT WOS:000322352200048
ER

PT J
AU Plumb, AM
   Plexico, LW
AF Plumb, Allison M.
   Plexico, Laura W.
TI Autism Spectrum Disorders: Experience, Training, and Confidence Levels
   of School-Based Speech-Language Pathologists
SO LANGUAGE SPEECH AND HEARING SERVICES IN SCHOOLS
LA English
DT Article
DE autism; school-based services; education; scholarship of teaching and
   learning
ID KNOWLEDGE
AB Purpose: To investigate the graduate training experiences of school-based speech-language pathologists (SLPs) working with children with autism spectrum disorders (ASDs). Comparisons were made between recent graduates (post 2006) and pre-2006 graduates to determine if differences existed in their academic and clinical experiences or their confidence in working with children with ASDs.
   Method: A 46-item, web-based, national survey was used. Participants were recruited through e-mail and listservs for American Speech-Language-Hearing Association Special Interest Divisions 1 (Language, Learning, and Education) and 16 (School-Based Issues).
   Results: Recent graduates reported a greater amount of graduate coursework relating to ASDs than pre-2006 graduates. However, the pre-2006 graduates reported significantly greater confidence in the areas of counseling parents of children who exhibit "red flags" of ASDs and addressing social communication, literacy, and academics in intervention.
   Conclusion: Results of the current survey indicated an increase in the amount of preprofessional training that SLPs receive relating to ASDs. Nonetheless, the majority of SLPs reported that they could have benefitted from additional clinical experience and training working with children with ASDs. The greater degree of confidence reported by the pre-2006 graduates highlights the importance of experience and continuing education for professionals in the field of speech-language pathology.
C1 [Plumb, Allison M.; Plexico, Laura W.] Auburn Univ, Auburn, AL 36849 USA.
RP Plumb, AM (reprint author), Auburn Univ, Auburn, AL 36849 USA.
EM amp0016@auburn.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1987, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   American Speech-Language-Hearing Association, 2006, KNOWL SKILLS NEED SP, DOI 10.1044/policy.KS2006-00075
   American Speech-Language-Hearing Association, 2006, TECHNICAL REPORT
   American Speech-Language-Hearing Association, 2006, ROL RESP SPEECH LANG
   American Speech-Language-Hearing Association, 2006, GUID SPEECH LANG PAT
   Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
   Balandin S, 1998, AUGMENTATIVE ALTERNA, V14, P239, DOI 10.1080/07434619812331278416
   Brisk B. J., 1997, LANG SPEECH HEAR SER, V28, P164
   Casby M. W., 1988, LANG SPEECH HEAR SER, V19, P352
   Cascella P., 2004, FOCUS AUTISM OTHER D, V19, P245, DOI 10.1177/10883576040190040601
   Compton M., 2009, COMMUNICATION DISORD, V30, P142
   Guiberson M., 2010, COMMUNICATION DISORD, V20, P1
   Hammer CS, 2004, J COMMUN DISORD, V37, P91, DOI 10.1016/j.jcomdis.2003.07.002
   Heidgerken AD, 2005, J AUTISM DEV DISORD, V35, P323, DOI 10.1007/s10803-005-3298-x
   Hux K, 1996, LANG SPEECH HEAR SER, V27, P171
   Kelly EM, 1997, LANG SPEECH HEAR SER, V28, P195
   Manley SB, 1999, AM J SPEECH-LANG PAT, V8, P171
   Roseberry-McKibbin C, 2005, LANG SPEECH HEAR SER, V36, P48, DOI 10.1044/0161-1461(2005/005)
   Schwartz H, 2008, LANG SPEECH HEAR SER, V39, P66, DOI 10.1044/0161-1461(2008/007)
   STONE WL, 1987, J PEDIATR PSYCHOL, V12, P615, DOI 10.1093/jpepsy/12.4.615
   Whitmire K. A., 2003, 1B5E COPSSE U FLOR
NR 23
TC 1
Z9 1
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 0161-1461
J9 LANG SPEECH HEAR SER
JI Lang. Speech Hear. Serv. Sch.
PD JAN 1
PY 2013
VL 44
IS 1
BP 89
EP 104
DI 10.1044/0161-1461(2012/11-0105)
PG 16
WC Linguistics; Rehabilitation
SC Linguistics; Rehabilitation
GA 190TK
UT WOS:000322362900008
PM 23087159
ER

PT J
AU Wilson, KP
AF Wilson, Kaitlyn P.
TI Incorporating Video Modeling Into a School-Based Intervention for
   Students With Autism Spectrum Disorders
SO LANGUAGE SPEECH AND HEARING SERVICES IN SCHOOLS
LA English
DT Article
DE video modeling; video self-modeling; autism spectrum disorder;
   school-based; speech-language pathology
ID OF-THE-LITERATURE; CHILDREN; SELF; SKILLS; PLAY; PRESCHOOLERS;
   METAANALYSIS; INDIVIDUALS; INSTRUCTION; SETTINGS
AB Purpose: Video modeling is an intervention strategy that has been shown to be effective in improving the social and communication skills of students with autism spectrum disorders, or ASDs. The purpose of this tutorial is to outline empirically supported, step-by-step instructions for the use of video modeling by school-based speech-language pathologists (SLPs) serving students with ASD.
   Method: This tutorial draws from the many reviews and meta-analyses of the video modeling literature that have been conducted over the past decade, presenting empirically supported considerations for school-based SLPs who are planning to incorporate video modeling into their service delivery for students with ASD. The 5 overarching procedural phases presented in this tutorial are (a) preparation, (b) recording of the video model, (c) implementation of the video modeling intervention, (d) monitoring of the student's response to the intervention, and (e) planning of the next steps.
   Conclusion: Video modeling is not only a promising intervention strategy for students with ASD, but it is also a practical and efficient tool that is well-suited to the school setting. This tutorial will facilitate school-based SLPs' incorporation of this empirically supported intervention into their existing strategies for intervention for students with ASD.
C1 [Wilson, Kaitlyn P.] Univ North Carolina Chapel Hill, Chapel Hill, NC 27515 USA.
   [Wilson, Kaitlyn P.] Kennedy Krieger Inst, Ctr Autism & Related Disorders, Baltimore, MD USA.
RP Wilson, KP (reprint author), Univ North Carolina Chapel Hill, Chapel Hill, NC 27515 USA.
EM wilsonka@kennedykrieger.org
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Speech-Language-Hearing Association, 2010, ROL RESP SPEECH LANG
   American Speech-Language-Hearing Association, 2005, EV BAS PRACT COMM DI
   Ayres KM, 2005, EDUC TRAIN DEV DISAB, V40, P183
   Bandura A., 1969, HDB SOCIALIZATION TH, P213
   Bellini S, 2007, EXCEPT CHILDREN, V73, P264
   Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
   Bishop D. V. M., 2003, CHILDRENS COMMUNICAT
   Bowers L., 2010, SOCIAL LANGUAGE DEV
   Bowers L., 2008, SOCIAL LANGUAGE DEV
   Carr JE, 2000, J APPL BEHAV ANAL, V33, P353, DOI 10.1901/jaba.2000.33-353
   CHARLOP MH, 1989, J APPL BEHAV ANAL, V22, P275, DOI 10.1901/jaba.1989.22-275
   Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276
   Charlop-Christy MH, 2003, J POSIT BEHAV INTERV, V5, P12, DOI 10.1177/10983007030050010101
   Cihak D, 2010, J POSIT BEHAV INTERV, V12, P103, DOI 10.1177/1098300709332346
   Closs S., 1998, INT J THERAPY REHABI, V5, P151
   Constantino JN, 2002, SOCIAL RESPONSIVENES
   Corbett B. A., 2005, J EARLY INTENSIVE BE, V2, P2
   Coyle C, 2004, J INTELLECT DEV DIS, V29, P3, DOI 10.1080/08927020410001662642
   Curtin M, 2001, BRIT J OCCUPATIONAL, V64, P214
   Delano ME, 2007, REM SPEC EDUC, V28, P33, DOI 10.1177/07419325070280010401
   Gray C. A., 1993, FOCUS AUTISTIC BEHAV, V8, P1, DOI DOI 10.1177/108835769300800101
   Groden J., 1995, TEACHING CHILDREN AU, P287
   Hermansen E, 2007, ED TREATMENT CHILDRE, V30, P183, DOI DOI 10.1353/ETC.2007.0029
   Hine JF, 2006, TOP EARLY CHILD SPEC, V26, P83, DOI 10.1177/02711214060260020301
   Hitchcock CH, 2003, REM SPEC EDUC, V24, P36, DOI 10.1177/074193250302400104
   Hume K, 2009, J AUTISM DEV DISORD, V39, P1329, DOI 10.1007/s10803-009-0751-2
   Kennedy M., 2002, INTRO CLIN METHODS C, P43
   Lord C., 2012, AUTISM DIAGNOSTIC 1
   MacDonald R, 2009, J APPL BEHAV ANAL, V42, P43, DOI 10.1901/jaba.2009.42-43
   Mechling L., 2005, Journal of Special Education Technology, V20
   Mineo BA, 2009, J AUTISM DEV DISORD, V39, P172, DOI 10.1007/s10803-008-0616-0
   Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303
   National Research Council, 2001, ED CHILDR AUT
   Nikopoulos C. K., 2007, J SPEECH LANGUAGE PA, V2, P195
   Nikopoulos CK, 2007, J AUTISM DEV DISORD, V37, P678, DOI 10.1007/s10803-006-0195-x
   Nikopoulos CK, 2009, J POSIT BEHAV INTERV, V11, P198, DOI 10.1177/1098300708325263
   Nikopoulos CK, 2004, J APPL BEHAV ANAL, V37, P93, DOI 10.1901/jaba.2004.37-93
   Odom S. L., 2003, FOCUS AUTISM OTHER D, V18, P166, DOI DOI 10.1177/10883576030180030401
   Paterson CR, 2007, BEHAV MODIF, V31, P660, DOI 10.1177/0145445507301651
   Rayner C, 2009, RES AUTISM SPECT DIS, V3, P291, DOI 10.1016/j.rasd.2008.09.001
   Reagon K. A., 2006, EDUC TREAT CHILD, V29, P517
   Roberts A., 2001, BRIT J OCCUPATIONAL, V64, P223
   Rogers SJ, 2000, J AUTISM DEV DISORD, V30, P399, DOI 10.1023/A:1005543321840
   Schreibman L., 2000, J POSIT BEHAV INTERV, V1, P3
   Schwartz H, 2008, LANG SPEECH HEAR SER, V39, P66, DOI 10.1044/0161-1461(2008/007)
   Sherer M, 2001, BEHAV MODIF, V25, P140, DOI 10.1177/0145445501251008
   Shukla-Mehta S, 2010, FOCUS AUTISM DEV DIS, V25, P23, DOI 10.1177/1088357609352901
   Sigafoos J., 2007, J BEHAV ED, V16, P93, DOI DOI 10.1007/S10864-006-9004-Z
   Sigafoos J., 2007, USE VIDEO MODELING V
   Simpson A, 2004, EDUC TRAIN DEV DISAB, V39, P240
   STRAIN PS, 1994, J EMOT BEHAV DISORD, V2, P78
   Vygotsky Lev Semyonovitch, 1978, MIND SOC DEV HIGHER
   Watson J. B., 1997, BEHAVIORISM, P3
   Wert BY, 2003, J POSIT BEHAV INTERV, V5, P30, DOI 10.1177/10983007030050010501
   WITT JC, 1983, PSYCHOL SCHOOLS, V20, P510, DOI 10.1002/1520-6807(198310)20:4<510::AID-PITS2310200420>3.0.CO;2-1
NR 56
TC 4
Z9 4
PU AMER SPEECH-LANGUAGE-HEARING ASSOC
PI ROCKVILLE
PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA
SN 0161-1461
J9 LANG SPEECH HEAR SER
JI Lang. Speech Hear. Serv. Sch.
PD JAN 1
PY 2013
VL 44
IS 1
BP 105
EP 117
DI 10.1044/0161-1461(2012/11-0098)
PG 13
WC Linguistics; Rehabilitation
SC Linguistics; Rehabilitation
GA 190TK
UT WOS:000322362900009
PM 23087158
ER

PT J
AU Aguado, L
   Roman, FJ
   Rodriguez, S
   Dieguez-Risco, T
   Romero-Ferreiro, V
   Fernandez-Cahill, M
AF Aguado, Luis
   Roman, Francisco J.
   Rodriguez, Sonia
   Dieguez-Risco, Teresa
   Romero-Ferreiro, Veronica
   Fernandez-Cahill, Maria
TI Learning of Facial Responses to Faces Associated with Positive or
   Negative Emotional Expressions
SO SPANISH JOURNAL OF PSYCHOLOGY
LA English
DT Article
DE associative learning; facial expressions of emotion; happy faces; angry
   faces; EMG
ID MIMICRY REACTIONS; INDIVIDUAL-DIFFERENCES; INFORMATION; STIMULI;
   EMPATHY; AUTISM; EMG
AB The possibility that facial expressions of emotion change the affective valence of faces through associative learning was explored using facial electromyography (EMG). In Experiment 1, EMG activity was registered while the participants (N = 57) viewed sequences of neutral faces (Stimulus 1 or S1) changing to either a happy or an angry expression (Stimulus 2 or S2). As a consequence of learning, participants who showed patterning of facial responses in the presence of angry and happy faces, that is, higher Corrugator Supercilii (CS) activity in the presence of angry faces and higher Zygomaticus Major (ZM) activity in the presence of happy faces, showed also a similar pattern when viewing the corresponding S1 faces. Explicit evaluations made by an independent sample of participants (Experiment 2) showed that evaluation of S1 faces was changed according to the emotional expression with which they had been associated. These results are consistent with an interpretation of rapid facial reactions to faces as affective responses that reflect the valence of the stimulus and that are sensitive to learned changes in the affective meaning of faces.
C1 [Aguado, Luis; Rodriguez, Sonia; Dieguez-Risco, Teresa; Romero-Ferreiro, Veronica; Fernandez-Cahill, Maria] Univ Complutense, Madrid, Spain.
   [Roman, Francisco J.] Univ Autonoma Madrid, E-28049 Madrid, Spain.
RP Aguado, L (reprint author), Fac Psicol, Campus Somosaguas, Madrid 28223, Spain.
EM laguado@psi.ucm.es
RI Roman, Francisco J./B-4576-2011
OI Roman, Francisco J./0000-0003-2342-9531
CR Achaibou A, 2008, NEUROPSYCHOLOGIA, V46, P1104, DOI 10.1016/j.neuropsychologia.2007.10.019
   Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   Aguado L, 2012, J PSYCHOPHYSIOL, V26, P29, DOI 10.1027/0269-8803/a000065
   Ayers ED, 2002, J NEUROSCI METH, V114, P33, DOI 10.1016/S0165-0270(01)00505-2
   Berridge KC, 2000, NEUROSCI BIOBEHAV R, V24, P173, DOI 10.1016/S0149-7634(99)00072-X
   Blessing A, 2006, NEUROPSYCHOLOGIA, V44, P2366, DOI 10.1016/j.neuropsychologia.2006.05.004
   Bliss-Moreau E, 2008, EMOTION, V8, P479, DOI 10.1037/1528-3542.8.4.479
   Bradley MM, 2001, EMOTION, V1, P276, DOI 10.1037//1528-3542.1.3.276
   Bradley MM, 2000, PSYCHOPHYSIOLOGY, V37, P204, DOI 10.1017/S0048577200990012
   Bunce SC, 1999, J PSYCHIAT RES, V33, P341, DOI 10.1016/S0022-3956(99)00003-5
   Chartrand TL, 1999, J PERS SOC PSYCHOL, V76, P893, DOI 10.1037//0022-3514.76.6.893
   De Houwer J, 2001, PSYCHOL BULL, V127, P853, DOI 10.1037//0033-2909.127.6.853
   DIMBERG U, 1982, PSYCHOPHYSIOLOGY, V19, P643, DOI 10.1111/j.1469-8986.1982.tb02516.x
   DIMBERG U, 1987, BIOL PSYCHOL, V24, P105, DOI 10.1016/0301-0511(87)90018-4
   Dimberg U, 1996, MOTIV EMOTION, V20, P149, DOI 10.1007/BF02253869
   Dimberg U, 2000, PSYCHOL SCI, V11, P86, DOI 10.1111/1467-9280.00221
   Dimberg U, 1998, SCAND J PSYCHOL, V39, P39, DOI 10.1111/1467-9450.00054
   FRIDLUND AJ, 1986, PSYCHOPHYSIOLOGY, V23, P567, DOI 10.1111/j.1469-8986.1986.tb00676.x
   Frith CD, 2007, PHILOS T R SOC B, V362, P671, DOI 10.1098/rstb.2006.2003
   Hess U, 1998, COGNITION EMOTION, V12, P509, DOI 10.1080/026999398379547
   Hess U., 2008, METHODS SOCIAL NEURO, P70
   Kohler CG, 2010, SCHIZOPHRENIA BULL, V36, P1009, DOI 10.1093/schbul/sbn192
   LAIRD JD, 1994, MOTIV EMOTION, V18, P231, DOI 10.1007/BF02254830
   Lakin JL, 2003, J NONVERBAL BEHAV, V27, P145, DOI 10.1023/A:1025389814290
   Lieberman M. D., 2011, SOCIAL NEUROSCIENCE, P188
   Lundqvist D., 1998, AKDET
   Magnee MJCM, 2007, NEUROREPORT, V18, P369, DOI 10.1097/WNR.0b013e32801776e6
   Moody EJ, 2007, EMOTION, V7, P447, DOI 10.1037/1528-3542.7.2.447
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   Sloan DM, 2002, BIOL PSYCHOL, V60, P79, DOI 10.1016/S0301-0511(02)00044-3
   Sonnby-Borgstrom M, 2003, J NONVERBAL BEHAV, V27, P3, DOI 10.1023/A:1023608506243
   Sonnby-Borgstrom M, 2002, SCAND J PSYCHOL, V43, P433, DOI 10.1111/1467-9450.00312
   Sonnby-Borgstrom M, 2004, SCAND J PSYCHOL, V45, P103, DOI 10.1111/j.1467-9450.2004.00385.x
   Wixted J. T., 2009, LEARN MOTIV, V40, P74
NR 34
TC 1
Z9 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1138-7416
J9 SPAN J PSYCHOL
JI Span. J. Psychol.
PY 2013
VL 16
DI 10.1017/sjp.2013.31
PG 10
WC Psychology, Multidisciplinary
SC Psychology
GA 185FQ
UT WOS:000321952000024
PM 23866218
ER

PT J
AU de Lacy, N
   King, BH
AF de Lacy, Nina
   King, Bryan H.
BE NolenHoeksema, S
TI Revisiting the Relationship Between Autism and Schizophrenia: Toward an
   Integrated Neurobiology
SO ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 9
SE Annual Review of Clinical Psychology
LA English
DT Article; Book Chapter
DE pervasive developmental disorder; spectrum; neurodevelopment; mTOR;
   reelin; genetic; cortical parcellation; connectivity; coherence
ID FRAGILE-X PREMUTATION; SCHIZOTYPAL PERSONALITY-DISORDER; COPY NUMBER
   VARIATIONS; WHITE-MATTER VOLUMES; DE-NOVO MUTATIONS; NON-SPEECH SOUNDS;
   SPECTRUM DISORDERS; CORPUS-CALLOSUM; FUNCTIONAL CONNECTIVITY;
   PSYCHIATRIC-DISORDERS
AB Schizophrenia and autism have been linked since their earliest descriptions. Both are disorders of cerebral specialization originating in the embryonic period. Genetic, molecular, and cytologic research highlights a variety of shared contributory mechanisms that may lead to patterns of abnormal connectivity arising from altered development and topology. Overt behavioral pathology likely emerges during or after neurosensitive periods in which resource demands overwhelm system resources and the individual's ability to compensate using interregional activation fails. We are at the threshold of being able to chart autism and schizophrenia from the inside out. In so doing, the door is opened to the consideration of new therapeutics that are developed based upon molecular, synaptic, and systems targets common to both disorders.
C1 [de Lacy, Nina] Univ Washington, Seattle, WA 98195 USA.
   Seattle Childrens Hosp, Seattle, WA 98195 USA.
RP de Lacy, N (reprint author), Univ Washington, Seattle, WA 98195 USA.
EM bryan.king@seattlechildrens.org
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Akbarian S, 1996, ARCH GEN PSYCHIAT, V53, P425
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   American Psychiatric Association, 1980, DIAGN STAT MAN MENT
   Amminger GP, 2012, EARLY INTER IN PRESS
   Anderson Jeffrey S, 2011, Brain, V134, P3742, DOI 10.1093/brain/awr263
   Asperger H, 1944, EUR ARCH PSY CLIN N, V117, P76
   Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
   Avino TA, 2010, BRAIN RES, V1360, P138, DOI 10.1016/j.brainres.2010.08.091
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Bastiaansen JA, 2011, J AUTISM DEV DISORD, V41, P1256, DOI 10.1007/s10803-010-1157-x
   Beckmann H, 1999, EUR ARCH PSY CLIN N, V249, P44
   Ben-David E, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002556
   Benedetti F, 2010, GENES BRAIN BEHAV, V9, P365, DOI 10.1111/j.1601-183X.2010.00566.x
   Bergen SE, 2009, SCHIZOPHR RES, V109, P94, DOI 10.1016/j.schres.2009.02.009
   Bishop DVM, 2006, AM J MED GENET B, V141B, P117, DOI 10.1002/ajmg.b.30267
   Bleuler E., 1911, DEMENTIA PRAECOX ODE
   Bohner G, 2012, SCHIZOPHR RES, V137, P85, DOI 10.1016/j.schres.2012.01.020
   Bonati MT, 2007, NEUROGENETICS, V8, P169, DOI 10.1007/s10048-007-0086-0
   Bookheimer SY, 2008, J INT NEUROPSYCH SOC, V14, P922, DOI 10.1017/S135561770808140X
   BOON FFL, 1989, J AM ACAD CHILD PSY, V28, P606, DOI 10.1097/00004583-198907000-00022
   Bora E, 2009, PSYCHIAT CLIN NEUROS, V63, P663, DOI 10.1111/j.1440-1819.2009.02011.x
   Botella-Lopez A, 2010, NEUROBIOL DIS, V37, P682, DOI 10.1016/j.nbd.2009.12.006
   Boucher J, 2000, J CHILD PSYCHOL PSYC, V41, P847, DOI 10.1017/S0021963099006149
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   Budimirovic DB, 2011, DEV NEUROSCI-BASEL, V33, P379, DOI 10.1159/000330213
   Burdick KE, 2008, HUM MOL GENET, V17, P2462, DOI 10.1093/hmg/ddn146
   CAPPON D, 1953, CAN MED ASSOC J, V69, P44
   Cardy JEO, 2005, NEUROREPORT, V16, P521
   Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099
   Carrard A, 2011, BRAIN BEHAV, V1, P119, DOI 10.1002/brb3.23
   Casanova MF, 2010, BRAIN PATHOL, V20, P451, DOI 10.1111/j.1750-3639.2009.00319.x
   Casanova MF, 2009, J AUTISM DEV DISORD, V39, P751, DOI 10.1007/s10803-008-0681-4
   Cascella NG, 2010, SCHIZOPHR RES, V120, P63, DOI 10.1016/j.schres.2010.03.039
   Chance SA, 2005, BRAIN RES, V1046, P32, DOI 10.1016/j.brainres.2005.03.045
   Chattopadhyaya B, 2012, FRONT PSYCHIAT, V3, P1
   Chawarska K, 2011, ARCH GEN PSYCHIAT, V68, P1021, DOI 10.1001/archgenpsychiatry.2011.106
   Chenn A, 2003, CEREB CORTEX, V13, P599, DOI 10.1093/cercor/13.6.599
   CHUN JJM, 1989, J COMP NEUROL, V282, P555, DOI 10.1002/cne.902820407
   Coghlan S, 2012, NEUROSCI BIOBEHAV R, V36, P2044, DOI 10.1016/j.neubiorev.2012.07.005
   COLBERT E G, 1958, Calif Med, V89, P215
   Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
   Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524
   Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016
   Curtis CE, 2001, AM J PSYCHIAT, V158, P100, DOI 10.1176/appi.ajp.158.1.100
   Daniels J, 2008, PEDIATRICS, V121, P1357
   Dauvermann MR, 2012, CURR PHARM DESIGN, V18, P434
   de Achaval D, 2010, NEUROPSYCHOLOGIA, V48, P1209, DOI 10.1016/j.neuropsychologia.2009.12.019
   Dementieva YA, 2005, PEDIATR NEUROL, V32, P102, DOI 10.1016/j.pediatrneurol.2004.08.005
   Dong E, 2005, P NATL ACAD SCI USA, V102, P12578, DOI 10.1073/pnas.0505394102
   Dorph-Petersen KA, 2007, J COMP NEUROL, V501, P290, DOI 10.1002/cne.21243
   Downhill JE, 2000, SCHIZOPHR RES, V42, P193, DOI 10.1016/S0920-9964(99)00123-1
   Duchan E, 2012, PEDIATR CLIN N AM, V59, P27, DOI 10.1016/j.pcl.2011.10.003
   Eastwood SL, 2003, MOL PSYCHIATR, V8, P821, DOI 10.1038/sj.mp.4001371
   Ebstein RP, 2012, HORM BEHAV, V61, P359, DOI 10.1016/j.yhbeh.2011.12.014
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   Ehninger D, 2011, TRENDS MOL MED, V17, P78, DOI 10.1016/j.molmed.2010.10.002
   Farzin F, 2006, J DEV BEHAV PEDIATR, V27, pS137, DOI 10.1097/00004703-200604002-00012
   Fatemi SH, 2005, MOL PSYCHIATR, V10, P251, DOI 10.1038/sj.mp.4001613
   Fett AKJ, 2011, NEUROSCI BIOBEHAV R, V35, P573, DOI 10.1016/j.neubiorev.2010.07.001
   Fisher DJ, 2008, INT J PSYCHOPHYSIOL, V70, P3, DOI 10.1016/j.ijpsycho.2008.04.001
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Fonseca-Pedrero E, 2012, J PERS DISORD, V26, P539, DOI 10.1521/pedi.2012.26.4.539
   Franco SJ, 2011, NEURON, V69, P482, DOI 10.1016/j.neuron.2011.01.003
   Frotscher M, 2009, J NEURAL TRANSM, V116, P1451, DOI 10.1007/s00702-009-0228-7
   Carletti Francesco, 2012, Schizophr Bull, V38, P1170, DOI 10.1093/schbul/sbs053
   Gillberg C, 2002, DEV MED CHILD NEUROL, V44, P296
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Gilmore JH, 2010, AM J PSYCHIAT, V167, P1083, DOI 10.1176/appi.ajp.2010.09101492
   Glantz L, 2000, ARCH GEN PSYCHIAT, V51, P65
   Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x
   Goodlin-Jones BL, 2004, J DEV BEHAV PEDIATR, V25, P392, DOI 10.1097/00004703-200412000-00002
   Gothelf D, 1997, AM J MED GENET, V72, P455
   GOTTESMAN II, 1976, SCHIZOPHRENIA BULL, V2, P360
   Grant S, 2012, CURR OPIN NEUROBIOL, V22, P1
   Grayton HM, 2012, PROG NEUROBIOL, V99, P81, DOI 10.1016/j.pneurobio.2012.07.005
   Green T, 2009, J AM ACAD CHILD PSY, V48, P1060, DOI 10.1097/CHI.0b013e3181b76683
   Griswold AJ, 2012, HUM MOL GENET, V21, P3513, DOI 10.1093/hmg/dds164
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
   Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
   Hagerman R, 2011, J NEURODEV DISORD, V3, P211, DOI 10.1007/s11689-011-9084-5
   Hallerback MU, 2012, PSYCHIAT RES, V198, P12, DOI 10.1016/j.psychres.2012.01.016
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hardan AY, 2004, PSYCHIAT RES-NEUROIM, V131, P263, DOI 10.1016/j.pscychresns.2004.06.001
   Harris JM, 2007, BIOL PSYCHIAT, V62, P722, DOI 10.1016/j.biopsych.2006.11.027
   Hasson U, 2009, AUTISM RES, V2, P220, DOI 10.1002/aur.89
   Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366
   Hazlett HC, 2012, AM J PSYCHIAT, V169, P601, DOI 10.1176/appi.ajp.2012.11091425
   Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110
   Hessl D, 2007, BRAIN, V130, P404, DOI 10.1093/brain/awl338
   Hetts SW, 2006, AM J ROENTGENOL, V187, P1343, DOI 10.2214/AJR.05.0146
   Hinkley LBN, 2011, BIOL PSYCHIAT, V70, P1134, DOI 10.1016/j.biopsych.2011.06.029
   Hoistad M, 2012, NEUROPATHOL IN PRESS, DOI [10.1111/j.1365-2990.2012.01296.x, DOI 10.1111/J.1365-2990.2012.01296.X.]
   Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
   Honea R, 2005, AM J PSYCHIAT, V162, P2233, DOI 10.1176/appi.ajp.162.12.2233
   Houston I, 2012, NEUROPSYCHOPHARMACOL, V38, P183
   Houzel JC, 1999, J PHYSIOLOGY-PARIS, V93, P271, DOI 10.1016/S0928-4257(00)80056-X
   Hutsler JJ, 2007, BIOL PSYCHIAT, V61, P449, DOI 10.1016/j.biopsych.2006.01.015
   Innocenti GM, 2003, MOL PSYCHIATR, V8, P261, DOI 10.1038/sj.mp.4001205
   Jacobson M., 1991, DEV NEUROBIOLOGY
   Jones EG, 1997, SCHIZOPHRENIA BULL, V23, P483
   Joshi D, 2012, BIOL PSYCHIAT, V72, P725, DOI 10.1016/j.biopsych.2012.06.021
   Jossin Y, 2011, NAT NEUROSCI, V14, P697, DOI 10.1038/nn.2816
   Jou RJ, 2011, AUST NZ J PSYCHIAT, V45, P153, DOI 10.3109/00048674.2010.534069
   Jou RJ, 2010, J CHILD NEUROL, V25, P1462, DOI 10.1177/0883073810368311
   Kakooza-Mwesige A, 2008, EUR CHILD ADOLES PSY, V17, P327, DOI 10.1007/s00787-008-0676-x
   Kalkman HO, 2012, NEUROSCI BIOBEHAV R, V36, P2206, DOI 10.1016/j.neubiorev.2012.07.008
   Kana RK, 2011, PHYS LIFE REV, V8, P410, DOI 10.1016/j.plrev.2011.10.001
   Kandel E. R., 1979, J NEUROPSYCHIATRY CL, V13, P290
   Kang EC, 2011, NEURON, V72, P559, DOI 10.1016/j.neuron.2011.09.032
   Kanner L., 1943, ACTA PAEDOPSYCHIATR, V35, P100
   Karam CS, 2010, TRENDS PHARMACOL SCI, V31, P381, DOI 10.1016/j.tips.2010.05.004
   Kasai K, 2003, SCHIZOPHR RES, V59, P159, DOI 10.1016/S0920-9964(01)00382-6
   Kasai K, 2005, CLIN NEUROPHYSIOL, V116, P1655, DOI 10.1016/j.clinph.2005.03.007
   Kates WR, 2011, J AM ACAD CHILD PSY, V50, P272, DOI 10.1016/j.jaac.2010.12.002
   Keary CJ, 2009, J AUTISM DEV DISORD, V39, P834, DOI 10.1007/s10803-009-0689-4
   Kehrer C, 2008, FRONT MOL NEUROSCI, V1, P1
   Kilian S, 2008, DEV NEUROPSYCHOL, V33, P74, DOI 10.1080/87565640701729821
   Kim JY, 2012, CELL, V148, P1051, DOI 10.1016/j.cell.2011.12.037
   King BH, 2011, BRAIN RES, V1380, P34, DOI 10.1016/j.brainres.2010.11.031
   King BH, 2006, CHILD ADOL PSYCH CL, V15, P161, DOI 10.1016/j.chc.2005.08.005
   Kirov G, 2009, HUM MOL GENET, V18, P1497, DOI 10.1093/hmg/ddp043
   Kocherhans S, 2010, J NEUROSCI, V30, P9228, DOI 10.1523/JNEUROSCI.0418-10.2010
   Kolluri N, 2005, AM J PSYCHIAT, V162, P1200, DOI 10.1176/appi.ajp.162.6.1200
   Konstantareas MM, 2001, J AUTISM DEV DISORD, V31, P19, DOI 10.1023/A:1005605528309
   Kostovic I, 2007, NEUROSCI BIOBEHAV R, V31, P1157, DOI 10.1016/j.neubiorev.2007.04.018
   Kostovic I, 2011, INT J DEV NEUROSCI, V29, P193, DOI 10.1016/j.ijdevneu.2010.09.005
   Kotulska Katarzyna, 2011, Eur J Paediatr Neurol, V15, P177, DOI 10.1016/j.ejpn.2010.08.007
   Ben Bashat Dafna, 2007, Neuroimage, V37, P40, DOI 10.1016/j.neuroimage.2007.04.060
   Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
   Kundakovic M, 2007, MOL PHARMACOL, V71, P644, DOI 10.1124/mol.106.030635
   Kunugi H, 1996, SCHIZOPHR RES, V20, P165
   Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123
   LeBlanc JJ, 2011, NEURAL PLAST, DOI 10.1155/2011/921680
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Lopez-Garcia P, 2006, PSYCHIAT RES-NEUROIM, V147, P153, DOI 10.1016/j.pscychresns.2006.04.007
   Lysaker PH, 2011, PSYCHIAT RES, V190, P18, DOI 10.1016/j.psychres.2010.07.016
   MacDonald K, 2012, ACTA NEUROPSYCHIATR, V24, P130, DOI 10.1111/j.1601-5215.2011.00634.x
   Marcotte L, 2012, ACTA NEUROPATHOL, V123, P685, DOI 10.1007/s00401-012-0950-3
   Mata I, 2000, SCHIZOPHR RES, V44, P129, DOI 10.1016/S0920-9964(99)00222-4
   Mata I, 2003, SCHIZOPHRENIA BULL, V29, P273
   McBride KL, 2010, AUTISM RES, V3, P127
   McDonald-McGinn DM, 1999, GENEREVIEWS
   McGrath J, 2004, BMC MED, V2, DOI 10.1186/1741-7015-2-13
   Meechan DW, 2011, INT J DEV NEUROSCI, V29, P283, DOI 10.1016/j.ijdevneu.2010.08.005
   Mefford HC, 2012, NEW ENGL J MED, V366, P733, DOI 10.1056/NEJMra1114194
   Mehl S, 2010, J NERV MENT DIS, V198, P516, DOI 10.1097/NMD.0b013e3181e4c8d2
   Mercier C., 1890, SANITY INSANITY
   Miles JH, 2003, GENEREVIEWS
   Missler M, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005694
   Mitelman SA, 2003, AM J PSYCHIAT, V160, P2154, DOI 10.1176/appi.ajp.160.12.2154
   Mitelman SA, 2007, NEUROIMAGE, V37, P449, DOI 10.1016/j.neuroimage.2007.04.070
   Montag C., 2012, WORLD J BIO IN PRESS
   Mori T, 2011, NEUROPEDIATRICS, V42, P215, DOI 10.1055/s-0031-1295479
   Mosconi MW, 2009, PSYCHOL MED, V39, P1559, DOI 10.1017/S0033291708004984
   Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x
   Mouridsen SE, 2008, J PSYCHIATR PRACT, V14, P5, DOI 10.1097/01.pra.0000308490.47262.e0
   Mouridsen SE, 2008, J NEURAL TRANSM, V115, P135, DOI 10.1007/s00702-007-0798-1
   MRZLJAK L, 1992, J COMP NEUROL, V316, P485, DOI 10.1002/cne.903160408
   Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
   Noonan SK, 2009, BRAIN RES, V1262, P48, DOI 10.1016/j.brainres.2008.12.076
   Noriuchi M, 2010, BRAIN RES, V1362, P141, DOI 10.1016/j.brainres.2010.09.051
   Oades RD, 2006, BMC PSYCHIATRY, V8, P6
   Oeschger FM, 2012, CEREB CORTEX, V22, P1343, DOI 10.1093/cercor/bhr197
   Okerlund ND, 2011, J NEURODEV DISORD, V3, P162, DOI 10.1007/s11689-011-9083-6
   ORNITZ EM, 1969, COMPR PSYCHIAT, V10, P259, DOI 10.1016/0010-440X(69)90002-9
   ORNITZ EM, 1970, COMPR PSYCHIAT, V11, P159, DOI 10.1016/0010-440X(70)90157-4
   O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989
   O'Roak BJ, 2008, AUTISM RES, V1, P4, DOI 10.1002/aur.3
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Paakki JJ, 2010, BRAIN RES, V1321, P169, DOI 10.1016/j.brainres.2009.12.081
   Palaniyappan L, 2011, BIOL PSYCHIAT, V69, P974, DOI 10.1016/j.biopsych.2010.12.012
   Philip RCM, 2012, NEUROSCI BIOBEHAV R, V36, P901, DOI 10.1016/j.neubiorev.2011.10.008
   Pierce K, 2011, BRAIN RES, V1380, P162, DOI 10.1016/j.brainres.2010.09.028
   PIVEN J, 1990, AM J PSYCHIAT, V147, P734
   Poot M, 2011, CYTOGENET GENOME RES, V135, P228, DOI 10.1159/000334064
   Porteous DJ, 2011, TRENDS MOL MED, V17, P699, DOI 10.1016/j.molmed.2011.09.002
   Pucilowska J, 2012, J NEUROSCI, V32, P8663, DOI 10.1523/JNEUROSCI.1107-12.2012
   Radhakrishnan R, 2011, PSYCHIAT RES, V189, P480, DOI 10.1016/j.psychres.2011.03.003
   Rakic P, 2009, COGNITIVE NEUROSCIEN, P7
   Ramamurthy Santosh, 2012, Exp Neurobiol, V21, P52, DOI 10.5607/en.2012.21.2.52
   Rapoport J, 2009, J AM ACAD CHILD PSY, V48, P10, DOI 10.1097/CHI.0b013e31818b1c63
   Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198
   Reaven Judith A, 2008, Clin Child Psychol Psychiatry, V13, P81, DOI 10.1177/1359104507086343
   Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026
   Roberts DL, 2010, PSYCHIAT RES, V178, P46, DOI 10.1016/j.psychres.2010.04.006
   Roberts TPL, 2008, INT J PSYCHOPHYSIOL, V68, P149, DOI 10.1016/j.ijpsycho.2008.01.012
   Robin NH, 2006, AM J MED GENET A, V140A, P2416, DOI 10.1002/ajmg.a.31443
   Rodriguez-Murillo L, 2012, ANNU REV MED, V63, P63, DOI 10.1146/annurev-med-072010-091100
   Rommelse NNJ, 2008, BRAIN COGNITION, V68, P391, DOI 10.1016/j.bandc.2008.08.025
   Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98
   Ross RG, 2002, PSYCHOPHYSIOLOGY, V39, P809, DOI 10.1017/S0048577202011691
   RUTTER M, 1972, J AUTISM CHILD SCHIZ, V2, P315, DOI 10.1007/BF01537622
   Sahoo T, 2008, NAT GENET, V40, P719, DOI 10.1038/ng.158
   Samaco RC, 2005, HUM MOL GENET, V14, P483, DOI 10.1093/hmg/ddi045
   Samuels IS, 2008, J NEUROSCI, V28, P6983, DOI 10.1523/JNEUROSCI.0679-08.2008
   Saul RA, 1998, GENEREVIEWS
   Schmeisser MJ, 2012, NATURE, V486, P256, DOI 10.1038/nature11015
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Sedel F, 2007, NAT CLIN PRACT NEURO, V3, P279, DOI 10.1038/ncpneuro0494
   Serpa MH, 2012, SCHIZOPHR RES, V137, P258, DOI 10.1016/j.schres.2012.02.027
   Sheikh AM, 2010, J NEUROSCI RES, V88, P2641, DOI 10.1002/jnr.22416
   Sheitman BB, 2004, SCHIZOPHR RES, V69, P119, DOI 10.1016/S0920-9964(03)00177-4
   Shokouhi M, 2012, AUTISM RES, V5, P245, DOI 10.1002/aur.1232
   Sigmundsson T, 2001, AM J PSYCHIAT, V158, P234, DOI 10.1176/appi.ajp.158.2.234
   Simms ML, 2009, ACTA NEUROPATHOL, V118, P673, DOI 10.1007/s00401-009-0568-2
   Singh KK, 2011, NEURON, V72, P545, DOI 10.1016/j.neuron.2011.09.030
   Skuse DH, 2005, BRIT J PSYCHIAT, V187, P568, DOI 10.1192/bjp.187.6.568
   SOBESKY WE, 1994, J AM ACAD CHILD PSY, V33, P247, DOI 10.1097/00004583-199402000-00014
   Spasic MR, 2009, NEUROSCIENTIST, V15, P309, DOI 10.1177/1073858408327805
   Stahlberg O, 2004, J NEURAL TRANSM, V111, P891, DOI 10.1007/s00702-004-0115-1
   Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006
   St Clair D, 2009, SCHIZOPHRENIA BULL, V35, P9, DOI 10.1093/schbul/sbn147
   Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
   Sullivan PF, 2003, ARCH GEN PSYCHIAT, V60, P1187, DOI 10.1001/archpsyc.60.12.1187
   Sverd Jeffrey, 2003, J Psychiatr Pract, V9, P111, DOI 10.1097/00131746-200303000-00003
   SZATMARI P, 1989, J AUTISM DEV DISORD, V19, P213, DOI 10.1007/BF02211842
   Talkowski ME, 2009, AM J MED GENET B, V150B, P560, DOI 10.1002/ajmg.b.30862
   Tam GWC, 2009, BIOL PSYCHIAT, V66, P1005, DOI 10.1016/j.biopsych.2009.07.027
   Taniai H, 2008, AM J MED GENET B, V147B, P844, DOI 10.1002/ajmg.b.30740
   TANTAM D, 1988, BRIT J PSYCHIAT, V153, P777, DOI 10.1192/bjp.153.6.777
   Tantam D., 1991, AUTISM ASPERGER SYND, P147, DOI 10.1017/CBO9780511526770.005
   Thiselton DL, 2008, BIOL PSYCHIAT, V63, P449, DOI 10.1016/j.biopsych.2007.06.005
   Thomas GM, 2004, NAT REV NEUROSCI, V5, P173, DOI 10.1038/nrn1346
   TISHLER PV, 1985, AM J PSYCHIAT, V142, P1430
   Travers BG, 2012, AUTISM RES, V5, P289, DOI 10.1002/aur.1243
   Ungvari GS, 2010, SCHIZOPHRENIA BULL, V36, P231, DOI 10.1093/schbul/sbp105
   Venkataraman A, 2012, SCHIZOPHR RES, V139, P7, DOI 10.1016/j.schres.2012.04.021
   Voets NL, 2008, NEUROIMAGE, V43, P665, DOI 10.1016/j.neuroimage.2008.08.013
   Walterfang M, 2008, SCHIZOPHR RES, V103, P1, DOI 10.1016/j.schres.2008.04.042
   Ward KE, 1996, SCHIZOPHR RES, V22, P197, DOI 10.1016/S0920-9964(96)00076-X
   Wass S, 2011, BRAIN COGNITION, V75, P18, DOI 10.1016/j.bandc.2010.10.005
   Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
   Welham J, 2009, SCHIZOPHRENIA BULL, V35, P603, DOI 10.1093/schbul/sbn084
   Welham J, 2009, AUST NZ J PSYCHIAT, V43, P61, DOI 10.1080/00048670802534333
   White T, 2011, DEV PSYCHOPATHOL, V23, P339, DOI 10.1017/S0954579410000842
   Whitehouse AJO, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023029
   WING L, 1981, PSYCHOL MED, V11, P115
   Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56
   Xu T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024129
   Yang K, 2011, GENES BRAIN BEHAV, V10, P834, DOI 10.1111/j.1601-183X.2011.00723.x
   Yang Y, 2011, BIOL PSYCHIAT, V69, P63, DOI 10.1016/j.biopsych.2010.08.020
   Yu QB, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025423
   Zalesky A, 2011, HUM BRAIN MAPP, V33, P2535
   Zheng WH, 2012, BRAIN RES, V1470, P145, DOI 10.1016/j.brainres.2012.06.032
   Zoghbi H.Y., 2012, COLD SPRING HARB PER, V4
NR 248
TC 15
Z9 15
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 1548-5943
BN 978-0-8243-3909-8
J9 ANNU REV CLIN PSYCHO
JI Annu. Rev. Clin. Psychol.
PY 2013
VL 9
BP 555
EP 587
DI 10.1146/annurev-clinpsy-050212-185627
PG 33
WC Psychology, Clinical; Psychology
SC Psychology
GA BFX16
UT WOS:000321742100022
PM 23537488
ER

PT J
AU Ganz, JB
   Heath, AK
   Davis, JL
   Vannest, KJ
AF Ganz, Jennifer B.
   Heath, Amy K.
   Davis, John L.
   Vannest, Kimberley J.
TI Effects of a Self-Monitoring Device on Socially Relevant Behaviors in
   Adolescents with Asperger Disorder: A Pilot Study
SO ASSISTIVE TECHNOLOGY
LA English
DT Article
DE autism; ASD; Asperger syndrome; self-monitoring; adolescents;
   communication; self-stimulatory behaviors
ID HIGH-FUNCTIONING AUTISM; SKILLS INTERVENTIONS; SPECTRUM DISORDERS;
   CHILDREN; MANAGEMENT; STRATEGIES; INCREASE; TASK; PRESCHOOLERS;
   CLASSROOM
AB This article reports the results of two case studies. Two middle school-aged participants with high-functioning autism spectrum disorders were taught to self-monitor behaviors impacting their social acceptance by peers in their general education settings: oral self-stimulatory behaviors and conversation skills. Results indicate that the intervention was effective to some degree with both participants. As a result of the self-monitoring intervention, one participant decreased self-stimulatory behaviors; however, his data were highly variable throughout the study though lower on average during intervention than in baseline. The other participant's targeted skills in communication were only slightly improved. Self-monitoring using a vibrating reminder appears to be a low-cost intervention with high levels of social acceptability, low training requirements for teachers or students, and no social stigma.
C1 [Ganz, Jennifer B.; Heath, Amy K.; Davis, John L.; Vannest, Kimberley J.] Texas A&M Univ, College Stn, TX 77843 USA.
RP Ganz, JB (reprint author), Texas A&M Univ, 4225 TAMU, College Stn, TX 77843 USA.
EM jeniganz@tamu.edu
RI Vannest, Kimberly/P-3577-2014
OI Vannest, Kimberly/0000-0002-2285-0837
CR Amato-Zech NA, 2006, PSYCHOL SCHOOLS, V43, P211, DOI 10.1002/pits.20137
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Barry TD, 2003, J AUTISM DEV DISORD, V33, P685, DOI 10.1023/B:JADD.0000006004.86556.e0
   Bauminger N, 2007, J AUTISM DEV DISORD, V37, P1605, DOI 10.1007/s10803-006-0246-3
   Beaumont R, 2008, J CHILD PSYCHOL PSYC, V49, P743, DOI 10.1111/j.1469-7610.2008.01920.x
   Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201
   Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
   Briesch AM, 2009, SCHOOL PSYCHOL QUART, V24, P106, DOI 10.1037/a0016159
   Cappadocia MC, 2011, RES AUTISM SPECT DIS, V5, P70, DOI 10.1016/j.rasd.2010.04.001
   Deitchman C, 2010, EDUC TREAT CHILD, V33, P475
   Dorminy KP, 2009, EDUC TRAIN DEV DISAB, V44, P538
   Ganz JB, 2005, EDUC TRAIN DEV DISAB, V40, P24
   Ganz JB, 2007, INTERV SCH CLIN, V42, P179
   Ganz JB, 2008, PREVENTING SCH FAILU, V53, P39, DOI DOI 10.3200/PSFL.53.1.39-48
   Gilliam J. E., 2001, G ASPERGERS DISORDER
   Haydon T., 2011, BEHAVIOUR, V20, P31
   Holifield C, 2010, FOCUS AUTISM DEV DIS, V25, P230, DOI 10.1177/1088357610380137
   Horner RH, 2005, EXCEPT CHILDREN, V71, P165
   Kamphaus R. W., 2003, RIAS REYNOLDS INTELL
   Kanner L, 1943, NERV CHILD, V2, P217
   Kazdin A. E., 1982, SINGLE CASE RES DESI
   KELLEY ML, 1989, J PSYCHOPATHOL BEHAV, V11, P235, DOI 10.1007/BF00960495
   KOEGEL LK, 1992, J APPL BEHAV ANAL, V25, P341, DOI 10.1901/jaba.1992.25-341
   KOEGEL RL, 1993, J APPL BEHAV ANAL, V26, P369, DOI 10.1901/jaba.1993.26-369
   Lee S. H., 2007, FOCUS AUTISM OTHER D, V22, P2, DOI DOI 10.1177/10883576070220010101
   Legge D. B., 2010, J BEHAV ASSESSMENT I, V1, P43
   Loftin RL, 2008, J AUTISM DEV DISORD, V38, P1124, DOI 10.1007/s10803-007-0499-5
   Lopata C, 2008, J AUTISM DEV DISORD, V38, P890, DOI 10.1007/s10803-007-0460-7
   Mace FC, 2001, SELF-REGULATED LEARNING AND ACADEMIC ACHIEVEMENT, SECOND ED., P39
   Morrison L., 2001, J POSIT BEHAV INTERV, V3, P237, DOI DOI 10.1177/109830070100300405
   Newman B, 1996, EDUC TRAIN MENT RET, V31, P304
   Newman B, 2000, BEHAV INTERVENT, V15, P145, DOI 10.1002/(SICI)1099-078X(200004/06)15:2<145::AID-BIN50>3.3.CO;2-V
   Parker D, 2011, FOCUS AUTISM DEV DIS, V26, P131, DOI 10.1177/1088357610376945
   RANKIN JL, 1995, INTERV SCH CLIN, V30, P181
   Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4
   Reinecke DR, 1999, EDUC TRAIN MENT RET, V34, P312
   Shearer D. D., 1996, EARLY EDUC DEV, V7, P205, DOI 10.1027/s15566935eed0703_1
   Soares DA, 2009, BEHAV INTERVENT, V24, P171, DOI 10.1002/bin.283
   Solomon M, 2004, J AUTISM DEV DISORD, V34, P649, DOI 10.1007/s10803-004-5286-y
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Stichter JP, 2010, J AUTISM DEV DISORD, V40, P1067, DOI [10.1007/s10803-010-0959-1, 10.1007/s10803-010-0968-0]
   STRAIN PS, 1994, J EMOT BEHAV DISORD, V2, P78
   Tantam D., 2000, AUTISM INT J RES PRA, V4, P47, DOI DOI 10.1177/1362361300004001004
   Temple-Harvey K., 2009, PREVENTING SCH FAILU, V53, P73, DOI DOI 10.3200/PSFL.53.2.73-84
   Thomeer M., 2006, FOCUS AUTISM OTHER D, V21, P237, DOI DOI 10.1177/10883576060210040501
NR 45
TC 2
Z9 2
PU R E S N A PRESS
PI ARLINGTON
PA 1700 MOORE ST, STE 1540, ARLINGTON, VA 22209-1903 USA
SN 1040-0435
J9 ASSIST TECHNOL
JI Assist. Technol.
PY 2013
VL 25
IS 3
BP 149
EP 157
DI 10.1080/10400435.2012.732655
PG 9
WC Rehabilitation
SC Rehabilitation
GA 188AE
UT WOS:000322162700003
PM 24020153
ER

PT S
AU Wahlsten, D
AF Wahlsten, Douglas
BE Lerner, RM
   Benson, JB
TI A Contemporary View of Genes and Behavior: Complex Systems and
   Interactions
SO EMBODIMENT AND EPIGENESIS: THEORETICAL AND METHODOLOGICAL ISSUES IN
   UNDERSTANDING THE ROLE OF BIOLOGY WITHIN THE RELATIONAL DEVELOPMENTAL
   SYSTEM, PT A: PHILOSOPHICAL, THEORETICAL, AND BIOLOGICAL DIMENSIONS
SE Advances in Child Development and Behavior
LA English
DT Article; Book Chapter
ID ENVIRONMENT INTERACTION; HUMAN GENOME; DE-NOVO; BRAIN; INTELLIGENCE;
   EXPRESSION; DISORDERS; TRAITS; MOUSE; MICE
AB Several large-scale searches for genes that influence complex human traits, such as intelligence and personality, in the normal range of variation have failed to identify even one gene that makes a significant difference. All previously published claims for genetic influences of this kind now appear to have been false positives. For more serious psychiatric and medical disorders such as schizophrenia and autism, several genes have been found where a rare mutation contributes to abnormal behavior, but in many instances they are de novo mutations not obtained from a parent. Despite the many disappointments in the search for genes influencing human behavior, the field of molecular genetics has made remarkable progress to the extent that several broadly applicable principles can now be affirmed. These principles show how development is regulated by networks of interacting genes that function in an environmental context. They invalidate several key assumptions of statistical genetic analysis that are made when estimating heritability. There is now a need to reform the teaching of genetics to our students and to restrict the funding of further searches for elusive genes that account for so little variance in normal behaviors.
C1 Univ N Carolina Greensboro, Dept Psychol, Greensboro, NC USA.
RP Wahlsten, D (reprint author), Univ N Carolina Greensboro, Dept Psychol, Greensboro, NC USA.
EM dlwahlst@uncg.edu
CR Alberts B., 2008, MOL BIOL CELL
   Dunham I, 2012, NATURE, V489, P57, DOI 10.1038/nature11247
   Birney E, 2012, NATURE, V489, P49, DOI 10.1038/489049a
   Boyle AP, 2012, GENOME RES, V22, P1790, DOI 10.1101/gr.137323.112
   Burns JG, 2012, P NATL ACAD SCI USA, V109, P17239, DOI 10.1073/pnas.1121265109
   Caspi A, 2006, NAT REV NEUROSCI, V7, P583, DOI 10.1038/nrn1925
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Chabris C. F., 2012, PSYCHOL SCI
   Davidson E.H., 2006, REGULATORY GENOME
   Davidson EH, 2006, SCIENCE, V311, P796, DOI 10.1126/science.1113832
   Davies G, 2011, MOL PSYCHIATR, V16, P996, DOI 10.1038/mp.2011.85
   Davies MN, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-6-r43
   Daxinger L, 2012, NAT REV GENET, V13, P153, DOI 10.1038/nrg3188
   Fagiolini M, 2009, CURR OPIN NEUROBIOL, V19, P207, DOI 10.1016/j.conb.2009.05.009
   Feng JA, 2007, PEDIATR RES, V61, p58R, DOI 10.1203/pdr.0b013e3180457635
   Fisher R. A., 1919, Transactions of the Royal Society of Edinburgh, V52
   Flint J, 2011, CHALLENGING GENETIC DETERMINISM: NEW PERSPECTIVES ON THE GENE IN ITS MULTIPLE ENVIRONMENTS, P78
   Gerstein MB, 2012, NATURE, V489, P91, DOI 10.1038/nature11245
   Gottlieb G, 2007, DEVELOPMENTAL SCI, V10, P1, DOI 10.1111/j.1467-7687.2007.00556.x
   HOOD KE, 1989, AGGRESSIVE BEHAV, V15, P361, DOI 10.1002/1098-2337(1989)15:5<361::AID-AB2480150505>3.0.CO;2-6
   Hughes M, 2007, COLD SPRING HARB SYM, V72, P381, DOI 10.1101/sqb.2007.72.011
   Ito T, 2001, P NATL ACAD SCI USA, V98, P4569, DOI 10.1073/pnas.061034498
   Johannsen W, 1911, AM NAT, V45, P129, DOI 10.1086/279202
   LEE SM, 1981, DIABETES, V30, P106, DOI 10.2337/diabetes.30.2.106
   LEESMILLER JP, 1990, MOL CELL BIOL, V10, P1729
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Li SM, 2004, SCIENCE, V303, P540, DOI 10.1126/science.1091403
   Lush JL, 1945, ANIMAL BREEDING PLAN
   Maher B, 2012, NATURE, V489, P46
   Matlin AJ, 2005, NAT REV MOL CELL BIO, V6, P386, DOI 10.1038/nrm1645
   Morgan T.H., 1914, POP SCI MONTHLY  JAN, P1
   Najmabadi H, 2011, NATURE, V478, P57, DOI 10.1038/nature10423
   Pan Q, 2008, NAT GENET, V40, P1413, DOI 10.1038/ng.259
   Paszkowski J, 2011, CURR OPIN PLANT BIOL, V14, P195, DOI 10.1016/j.pbi.2011.01.002
   PEREZCARPINELL J, 1992, OPTOMETRY VISION SCI, V69, P623, DOI 10.1097/00006324-199208000-00005
   Posthuma D, 2006, CURR DIR PSYCHOL SCI, V15, P151, DOI 10.1111/j.1467-8721.2006.00426.x
   Risch N, 2009, JAMA-J AM MED ASSOC, V301, P2462, DOI 10.1001/jama.2009.878
   Robinson GE, 2008, SCIENCE, V322, P896, DOI 10.1126/science.1159277
   Sacks O., 1997, ISLAND COLORBLIND
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sanyal A, 2012, NATURE, V489, P109, DOI 10.1038/nature11279
   Schaub MA, 2012, GENOME RES, V22, P1748, DOI 10.1101/gr.136127.111
   Scriver CR, 1999, TRENDS GENET, V15, P267, DOI 10.1016/S0168-9525(99)01761-8
   Sebat J, 2009, TRENDS GENET, V25, P528, DOI 10.1016/j.tig.2009.10.004
   Shaked I, 2008, ANN NY ACAD SCI, V1148, P269, DOI 10.1196/annals.1410.001
   Singh RK, 2009, EXP CELL RES, V315, P3419, DOI 10.1016/j.yexcr.2009.07.017
   Skinner MK, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003745
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Summers CG, 2009, OPTOMETRY VISION SCI, V86, P659, DOI 10.1097/OPX.0b013e3181a5254c
   Szyf M, 2009, BBA-GEN SUBJECTS, V1790, P878, DOI 10.1016/j.bbagen.2009.01.009
   WAHLSTEN D, 1990, BEHAV BRAIN SCI, V13, P109
   Wahlsten D, 2006, GENES BRAIN BEHAV, V5, P170, DOI 10.1111/j.1601-183X.2005.00153.x
   Wahlsten D, 2011, CHALLENGING GENETIC DETERMINISM: NEW PERSPECTIVES ON THE GENE IN ITS MULTIPLE ENVIRONMENTS, P51
   Wahlsten D, 2011, MOUSE BEHAVIORAL TESTING: HOW TO USE MICE IN BEHAVIORAL NEUROSCIENCE, P1
   Wahlsten D., 1982, Genetics of the brain, P367
   Wahlsten D, 1999, ANNU REV PSYCHOL, V50, P599, DOI 10.1146/annurev.psych.50.1.599
   Wahlsten D, 2012, DEV PSYCHOBIOL, V54, P475, DOI 10.1002/dev.21043
   WAHLSTEN D, 1991, PSYCHOL BULL, V110, P587, DOI 10.1037//0033-2909.110.3.587
   WAHLSTEN D, 1994, CAN PSYCHOL, V35, P244, DOI 10.1037/0708-5591.35.3.244
   Wolfer DP, 2002, TRENDS NEUROSCI, V25, P336, DOI 10.1016/S0166-2236(02)02192-6
   Wolstenholme JT, 2012, ENDOCRINOLOGY, V153, P3828, DOI 10.1210/en.2012-1195
   Yan J, 2008, PLOS COMPUT BIOL, V4, DOI 10.1371/journal.pcbi.1000193
   Youngson NA, 2008, ANNU REV GENOM HUM G, V9, P233, DOI 10.1146/annurev.genom.9.081307.164445
   Youngson NA, 2011, BIOESSAYS, V33, P95, DOI 10.1002/bies.201000122
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 65
TC 1
Z9 1
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0065-2407
BN 978-0-12-397947-6
J9 ADV CHILD DEV BEHAV
JI Adv. Child Develop. Behav.
PY 2013
VL 44
BP 285
EP 306
DI 10.1016/B978-0-12-397947-6.00010-6
PG 22
WC Psychology, Developmental
SC Psychology
GA BFQ37
UT WOS:000320963000011
PM 23834009
ER

PT S
AU Krimsky, S
AF Krimsky, Sheldon
BE Lerner, RM
   Benson, JB
TI Genetic Causation: A Cross Disciplinary Inquiry
SO EMBODIMENT AND EPIGENESIS: THEORETICAL AND METHODOLOGICAL ISSUES IN
   UNDERSTANDING THE ROLE OF BIOLOGY WITHIN THE RELATIONAL DEVELOPMENTAL
   SYSTEM, PT A: PHILOSOPHICAL, THEORETICAL, AND BIOLOGICAL DIMENSIONS
SE Advances in Child Development and Behavior
LA English
DT Article; Book Chapter
ID MONOAMINE-OXIDASE; ASSOCIATION; POLYMORPHISM; ENVIRONMENT; NETWORKS;
   AUTISM; GENOME
AB The growth of genome-wide and Candidate Gene Association Studies have elevated genetic causality in medicine and behavioral science. This chapter explores the concept of causality as it has been applied in genetic explanations and distinguishes the varieties of methods used to establish genetic causation. The essay ends with a cautionary note on applying genetic causation to compelx human behaviors and neurocognitive abnormalities.
C1 Tufts Univ, Dept Urban & Environm Policy & Planning, Medford, MA 02155 USA.
RP Krimsky, S (reprint author), Tufts Univ, Dept Urban & Environm Policy & Planning, Medford, MA 02155 USA.
EM sheldon.krimsky@tufts.edu
CR Alford JR, 2005, AM POLIT SCI REV, V99, P153
   Boomsma DI, 2006, BEHAV GENET, V36, P137, DOI 10.1007/s10519-005-9005-z
   Charney E, 2008, PERSPECT POLIT, V6, P299, DOI 10.1017/S1537592708080626
   Commoner B., 2002, HARPERS MAGAZINE, P30
   Dawes CT, 2009, J POLIT, V71, P1157, DOI 10.1017/S002238160909094X
   Delisi M, 2009, CRIM JUSTICE BEHAV, V36, P1187, DOI 10.1177/0093854809342884
   Fowler J. H., 2010, SOCIAL SCI RES NETWO
   Drmanac R, 2012, SCIENCE, V336, P1110, DOI 10.1126/science.1221037
   Dyck BA, 2009, SYNAPSE, V63, P662, DOI 10.1002/syn.20643
   English W., 2012, POLITICAL SCI RE FEB, P7
   Food and Drug Administration, 2001, FED REG, V66, P4706
   Fowler JH, 2011, P NATL ACAD SCI USA, V108, P1993, DOI 10.1073/pnas.1011687108
   Fowler JH, 2008, J POLIT, V70, P579, DOI 10.1017/S0022381608080638
   Fowler JH, 2008, AM POLIT SCI REV, V102, P233, DOI 10.1017/S0003055408080209
   Fowler JH, 2009, P NATL ACAD SCI USA, V106, P1720, DOI 10.1073/pnas.0806746106
   Garpenstrand H, 2002, NEUROPSYCHOBIOLOGY, V46, P190, DOI 10.1159/000067804
   Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003
   Joseph J., 2010, ETHICAL HUMAN PSYCHO, V12, p[200, 213]
   Kahn J., 2011, RACE GENETIC REVOLUT, P129
   Keski-Rahkonen A, 2004, BEHAV GENET, V34, P503, DOI 10.1023/B:BEGE.0000038488.22974.b1
   Koenig LB, 2005, J PERS, V73, P471, DOI 10.1111/j.1467-6494.2005.00316.x
   Landrigan PJ, 2012, ENVIRON HEALTH PERSP, V120, pA258, DOI 10.1289/ehp.1104285
   Li MY, 2011, SCIENCE, V333, P53, DOI 10.1126/science.1207018
   MacMahon B., 1968, TRANSMISSION SCHIZOP
   McDermott R, 2009, P NATL ACAD SCI USA, V106, P2118, DOI 10.1073/pnas.0808376106
   Mertins V., 2011, PLOS ONE, V6, P16
   Mill J. S., 1859, SYSTEM LOGIC
   Mingyao L., 2011, SCIENCE         0701, P53
   Noble D, 2008, PHILOS T R SOC A, V366, P3001, DOI 10.1098/rsta.2008.0086
   Plomin R., 2008, BEHAV GENETICS
   Quintana-Murci L, 2012, SCIENCE, V335, P806, DOI 10.1126/science.1219299
   Ridley Matt, 2003, NATURE VIA NURTURE
   Rosenthal D., 1979, PSYCHIAT GENETICS PA, P22
   Settle JE, 2010, J POLIT, V72, P1189, DOI 10.1017/S0022381610000617
   Stoltenberg SF, 1997, GENETICA, V99, P89, DOI 10.1007/BF02259512
   Strobel A, 1999, MOL PSYCHIATR, V4, P378, DOI 10.1038/sj.mp.4000535
   Turkheimer E, 2011, INT J EPIDEMIOL, V40, P598, DOI 10.1093/ije/dyq147
NR 37
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0065-2407
BN 978-0-12-397947-6
J9 ADV CHILD DEV BEHAV
JI Adv. Child Develop. Behav.
PY 2013
VL 44
BP 307
EP 323
DI 10.1016/B978-0-12-397947-6.00011-8
PG 17
WC Psychology, Developmental
SC Psychology
GA BFQ37
UT WOS:000320963000012
PM 23834010
ER

PT J
AU Banovsky, J
AF Banovsky, Juraj
TI On the Attribution of Mental States
SO FILOZOFIA
LA Slovak
DT Article
DE Theory of mind; Theory theory; Modularity; Autism
ID ASPERGER-SYNDROME; ANIMATED SHAPES; MIND; AUTISM; MODULARITY
AB The objective of this paper is to compare the theory theory and the theory of modularity. It is argued that the theory theory approach does not offer sufficient description of the ability to attribute mental states. The focus is on evaluation of evidence coming from various cognitive deficits, especially Autistic Spectrum Disorder. The paper suggests that the attribution of mental states is typically based on an implicit, mandatory and fast processing as opposed to inferential acquisition of knowledge.
C1 Katedra Filozofie FHV UMB, Banska Bystrica 97401, SR, Slovakia.
RP Banovsky, J (reprint author), Katedra Filozofie FHV UMB, Tajovskeho 10, Banska Bystrica 97401, SR, Slovakia.
EM juraj.banovsky@umb.sk
CR Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   BARON-COHEN S., 2009, DUSEVNA SLEPOTA NEVI
   Baron-Cohen Simon, 1997, MINDBLINDNESS ESSAY
   Castelli F, 2000, NEUROIMAGE, V12, P314, DOI 10.1006/nimg.2000.0612
   Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189
   Chomsky N, 1980, RULES REPRESENTATION
   FODOR JA, 1985, BEHAV BRAIN SCI, V8, P1
   Fodor Jerry A., 1983, MODULARITY MIND
   GERGELY G, 1995, COGNITION, V56, P165, DOI 10.1016/0010-0277(95)00661-H
   Gopnik A., 1996, THEORIES THEORIES MI, P169
   Gopnik A., 2000, SCI CRIB WHAT EARLY
   Griffin R., 2008, SOCIAL COGNITION DEV, P254
   Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950
   Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101
   LILLARD A. S., 2005, NEW UNCONSCIOUS
   MCALEER P., 2011, AUTISM DEV DISORD, V41, P1064
   McGeer V, 2001, J CONSCIOUSNESS STUD, V8, P109
   SACKS O., 1997, ANTROPOLOZKA MARSU
   Sacks O., 1986, MAN WHO MISTOOK HIS
   Scholl BJ, 1999, MIND LANG, V14, P131, DOI 10.1111/1468-0017.00106
   Sellars Wilfrid, 1963, SCI PERCEPTION REALI, P127
NR 22
TC 0
Z9 0
PU FILOZOFIA
PI BRATISLAVA 1
PA KLEMENSOVA 19, 813 64 BRATISLAVA 1, SLOVAKIA
SN 0046-385X
J9 FILOZOFIA
JI Filozofia
PY 2013
VL 68
IS 6
BP 530
EP 538
PG 9
WC Philosophy
SC Philosophy
GA 175KU
UT WOS:000321230400008
ER

PT J
AU Lang, R
   Sigafoos, J
   van der Meer, L
   O'Reilly, MF
   Lancioni, GE
   Didden, R
AF Lang, Russell
   Sigafoos, Jeff
   van der Meer, Larah
   O'Reilly, Mark F.
   Lancioni, Giulio E.
   Didden, Robert
BE Hastings, RP
   Rojahn, J
TI Early Signs and Early Behavioral Intervention of Challenging Behavior
SO INTERNATIONAL REVIEW OF RESEARCH IN DEVELOPMENTAL DISABILITIES:
   CHALLENGING BEHAVIOR, VOL 44
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID SELF-INJURIOUS-BEHAVIOR; AUTISM SPECTRUM DISORDER; FRAGILE-X-SYNDROME;
   FUNCTIONAL-ANALYSIS; INTELLECTUAL DISABILITIES; TOTAL POPULATION;
   MENTAL-RETARDATION; AGGRESSIVE-BEHAVIOR; PRECURSOR BEHAVIOR;
   GENETIC-DISORDERS
AB This chapter summarizes research on the emergence of challenging behavior and early behavioral intervention for the treatment of challenging behavior in young children with Intellectual Disability (ID). Biological and learning theories related to the emergence of challenging behavior and risk factors for challenging behavior, which include a variety of constitutional (e.g. intelligence quotient, syndrome, adaptive behavior deficits) and environmental variables (e. g. reinforcement contingencies), are reviewed. Literature related to precursor behaviors that reliably predict challenging behavior is also reviewed. Data support the use of behavioral intervention to reduce challenging behavior in young children with ID. A two-phase model involving functional analysis followed by function-based treatments appears to produce the largest effect sizes. Additional research is required to establish the utility of preventing challenging behavior by reducing risk factors and/or through the treatment of precursor behavior. Future research should also aim to more fully explore child characteristics that might predict intervention outcomes.
C1 [Lang, Russell] Texas State Univ San Marcos, Clin Autism Res Evaluat & Support, San Marcos, TX USA.
   [Sigafoos, Jeff; van der Meer, Larah] Victoria Univ Wellington, Sch Educ Psychol, Wellington, New Zealand.
   [Lang, Russell; O'Reilly, Mark F.] Univ Texas Austin, Meadows Ctr Preventing Educ Risk, Austin, TX 78712 USA.
   [Lancioni, Giulio E.] Univ Bari, Dept Neurosci & Sense Organs, Bari, Italy.
   [Didden, Robert] Radboud Univ Nijmegen, Inst Behav Sci, NL-6525 ED Nijmegen, Netherlands.
RP Sigafoos, J (reprint author), Victoria Univ Wellington, Sch Educ Psychol, Wellington, New Zealand.
EM jeff.sigafoos@vuw.ac.nz
CR Arron K, 2011, J INTELL DISABIL RES, V55, P109, DOI 10.1111/j.1365-2788.2010.01337.x
   Bachmeyer MH, 2009, J APPL BEHAV ANAL, V42, P641, DOI 10.1901/jaba.2009.42-641
   Carr E. G., 1994, COMMUNICATION BASED
   CARR EG, 1985, J APPL BEHAV ANAL, V18, P111, DOI 10.1901/jaba.1985.18-111
   Chan JM, 2011, RES AUTISM SPECT DIS, V5, P715, DOI 10.1016/j.rasd.2010.08.005
   Chawick O., 2008, J INTELL DISABIL RES, V52, P864
   de Vries P, 2009, J INTELL DISABIL RES, V53, P829, DOI 10.1111/j.1365-2788.2009.01209.x
   Didden R, 2006, AM J MENT RETARD, V111, P290, DOI 10.1352/0895-8017(2006)111[290:BTOCBI]2.0.CO;2
   Didden R, 1997, AM J MENT RETARD, V101, P387
   Didden R., 2007, J APPL RES INTELLECT, V22, P526
   Dracobly JD, 2012, J APPL BEHAV ANAL, V45, P361, DOI 10.1901/jaba.2012.45-361
   Durand V. M., 1986, ADV LEARNING BEHAVIO, V5, P141
   DYKENS EM, 1995, AM J MENT RETARD, V99, P522
   Emerson E, 2001, RES DEV DISABIL, V22, P77, DOI 10.1016/S0891-4222(00)00061-5
   Franco JH, 2009, FOCUS AUTISM DEV DIS, V24, P146, DOI 10.1177/1088357609338380
   Furniss F, 2012, J INTELL DISABIL RES, V56, P453, DOI 10.1111/j.1365-2788.2012.01534.x
   Granpeesheh D, 2009, RES AUTISM SPECT DIS, V3, P1014, DOI 10.1016/j.rasd.2009.06.007
   Gray C. A., 1993, FOCUS AUTISTIC BEHAV, V8, P1, DOI DOI 10.1177/108835769300800101
   Green VA, 2005, RES DEV DISABIL, V26, P47, DOI 10.1016/j.ridd.2004.07.003
   Grey IM, 2005, CURR OPIN PSYCHIATR, V18, P469, DOI 10.1097/01.yco.0000179482.54767.cf
   Guralnick MJ, 2005, J APPL RES INTELLECT, V18, P313, DOI 10.1111/j.1468-3148.2005.00270.x
   Hanley GP, 2003, J APPL BEHAV ANAL, V36, P147, DOI 10.1901/jaba.2003.36-147
   Harris JC, 2010, AM J MED GENET C, V154C, P389, DOI 10.1002/ajmg.c.30276
   Harris SL, 2000, J AUTISM DEV DISORD, V30, P137, DOI 10.1023/A:1005459606120
   Hartley SL, 2008, J INTELL DISABIL RES, V52, P819, DOI 10.1111/j.1365-2788.2008.01065.x
   Harvey ST, 2009, J INTELLECT DEV DIS, V34, P67, DOI 10.1080/13668250802690922
   Hastings RP, 2002, J INTELLECT DEV DIS, V27, P149, DOI 10.1080/1366825021000008657
   Herscovitch B, 2009, J APPL BEHAV ANAL, V42, P697, DOI 10.1901/jaba.2009.42-697
   Heyvaert M, 2010, J INTELL DISABIL RES, V54, P634, DOI 10.1111/j.1365-2788.2010.01291.x
   Hodapp RM, 2005, MENT RETARD DEV D R, V11, P340, DOI 10.1002/mrdd.20087
   Holden A, 2006, PARKINSONISM RELAT D, V12, P73, DOI 10.1016/j.parkreldis.2005.11.001
   Holden B, 2006, RES DEV DISABIL, V27, P456, DOI 10.1016/j.ridd.2005.06.001
   IWATA BA, 1994, J APPL BEHAV ANAL, V27, P215, DOI 10.1901/jaba.1994.27-215
   IWATA BA, 1982, ANAL INTERVEN DEVEL, V2, P3, DOI 10.1016/0270-4684(82)90003-9
   Jang JN, 2011, RES AUTISM SPECT DIS, V5, P1028, DOI 10.1016/j.rasd.2010.11.008
   Kanne SM, 2011, J AUTISM DEV DISORD, V41, P926, DOI 10.1007/s10803-010-1118-4
   Kennedy CH, 2001, J APPL BEHAV ANAL, V34, P539, DOI 10.1901/jaba.2001.34-539
   Kuhn SAC, 2009, J APPL BEHAV ANAL, V42, P679, DOI 10.1901/jaba.2009.42-679
   Kurtz PF, 2012, J MENT HEALTH RES IN, V5, P260, DOI 10.1080/19315864.2011.600809
   Kuttler S., 1998, FOCUS AUTISM OTHER D, V13, P176, DOI DOI 10.1177/108835769801300306
   Lancioni GE, 2012, AUT CHILD PSYCHO, P45, DOI 10.1007/978-1-4614-3037-7_4
   Lang R, 2013, J APPL BEHAV ANAL, V46, P322, DOI 10.1002/jaba.5
   Lang R, 2010, J APPL BEHAV ANAL, V43, P113, DOI 10.1901/jaba.2010.43-113
   Langthorne P, 2012, J AUTISM DEV DISORD, V42, P201, DOI 10.1007/s10803-011-1229-6
   Langthorne P, 2011, AJIDD-AM J INTELLECT, V116, P65, DOI 10.1352/1944-7558-116.1.65
   Lippert-Gruner M, 2006, BRAIN INJURY, V20, P569, DOI 10.1080/02699050600664467
   Lopez-Rangel E, 2008, BRIT J DEV DISABIL, V54, P69
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Luiselli J. K., 2012, HDB HIGH RISK CHALLE
   Lydon S, 2012, J DEV PHYS DISABIL, V24, P301, DOI 10.1007/s10882-012-9267-3
   Machalicek W, 2009, EDUC TRAIN DEV DISAB, V44, P207
   Matson JL, 2012, RES DEV DISABIL, V33, P630, DOI 10.1016/j.ridd.2011.11.006
   McCarthy J, 2008, J INTELL DISABIL RES, V52, P877, DOI 10.1111/j.1365-2788.2008.01104.x
   McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
   McTiernan A, 2011, RES AUTISM SPECT DIS, V5, P1215, DOI 10.1016/j.rasd.2011.01.009
   Muehlmann AM, 2012, J INTELL DISABIL RES, V56, P427, DOI 10.1111/j.1365-2788.2011.01519.x
   Murphy GH, 2005, J AUTISM DEV DISORD, V35, P405, DOI 10.1007/s10803-005-5030-2
   Najdowski AC, 2008, J APPL BEHAV ANAL, V41, P97, DOI 10.1901/jaba.2008.41-97
   Nash K, 2006, ARCH WOMEN MENT HLTH, V9, P181, DOI 10.1007/s00737-006-0130-3
   NYHAN WL, 1972, PEDIATR RES, V6, P1
   O'Reilly M., 2007, HDB INTELLECTUAL DIS, P253
   Oliver C, 2012, J AUTISM DEV DISORD, V42, P910, DOI 10.1007/s10803-011-1320-z
   OReilly MF, 1997, J APPL BEHAV ANAL, V30, P165, DOI 10.1901/jaba.1997.30-165
   Peters-Scheffer N., RES AUTISM IN PRESS
   Peters-Scheffer N, 2012, RES AUTISM SPECT DIS, V6, P696, DOI 10.1016/j.rasd.2011.10.003
   Poppes P, 2010, RES DEV DISABIL, V31, P1269, DOI 10.1016/j.ridd.2010.07.017
   Rapp JT, 2005, RES DEV DISABIL, V26, P527, DOI 10.1016/j.ridd.2004.11.005
   Reichle J., 1993, COMMUNICATIVE ALTERN, V3
   Richards C, 2012, J INTELL DISABIL RES, V56, P476, DOI 10.1111/j.1365-2788.2012.01537.x
   Richman D. M., 2012, J INTELLECTUAL DISAB
   Rispoli M, 2011, J APPL BEHAV ANAL, V44, P187, DOI 10.1901/jaba.2011.44-187
   Sigafoos J., 2003, CHALLENGING BEHAV DE
   Sigafoos J, 2009, AUTISM SPECTRUM DISO, P333
   Singh NN, 2011, AUT CHILD PSYCHO, P413, DOI 10.1007/978-1-4419-8065-6_26
   Skinner B. F, 1953, SCI HUMAN BEHAV
   Sloneem J, 2011, J INTELL DISABIL RES, V55, P138, DOI 10.1111/j.1365-2788.2010.01371.x
   Smith RG, 2002, J APPL BEHAV ANAL, V35, P125, DOI 10.1901/jaba.2002.35-125
   Symons F. J., 2012, HDB HIGH RISK CHALLE, P3
   Symons FJ, 2003, AM J MED GENET A, V118A, P115, DOI 10.1002/ajmg.a.10078
   Taggart L, 2010, J Intellect Disabil, V14, P267, DOI 10.1177/1744629510390449
   Taylor L, 2011, J APPL RES INTELLECT, V24, P105, DOI 10.1111/j.1468-3148.2010.00579.x
   Totsika V, 2009, CURR OPIN PSYCHIATR, V22, P437, DOI 10.1097/YCO.0b013e32832cd9b8
   Tunnicliffe P, 2011, RES DEV DISABIL, V32, P404, DOI 10.1016/j.ridd.2010.12.008
   Turner CA, 2002, SELF INJURIOUS BEHAV, P165, DOI 10.1037/10457-011
   van Nieuwenhuijzen M, 2009, J INTELL DISABIL RES, V53, P233, DOI 10.1111/j.1365-2788.2008.01112.x
   Wacker D. P., 1998, J DEV BEHAV PEDIATR, V19, P26
   Wacker D. P., 2009, LANGUAGE AUTISM APPL, P299
   Yoon S. J., 2002, SOC BEHAV PERSONAL, V30, P485, DOI DOI 10.2224/SBP.2002.30.5.485
NR 88
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-401725-2
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 44
BP 1
EP 35
DI 10.1016/B978-0-12-401662-0.00001-4
PG 35
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BFQ02
UT WOS:000320926000002
ER

PT J
AU Devine, DP
   Symons, FJ
AF Devine, Darragh P.
   Symons, Frank J.
BE Hastings, RP
   Rojahn, J
TI Biological Vulnerability and Risk for Self-Injury in Intellectual and
   Developmental Disabilities
SO INTERNATIONAL REVIEW OF RESEARCH IN DEVELOPMENTAL DISABILITIES:
   CHALLENGING BEHAVIOR, VOL 44
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID SEPARATION ANXIETY SYNDROME; PRADER-WILLI-SYNDROME;
   LESCH-NYHAN-SYNDROME; FRAGILE-X-SYNDROME; RHESUS-MONKEYS;
   NEURODEVELOPMENTAL DISORDERS; RETARDED-CHILDREN; YOUNG-CHILDREN;
   CHALLENGING BEHAVIORS; FUNCTIONAL-ANALYSIS
AB A broad spectrum of individuals with intellectual and developmental disabilities (I/DD) exhibit self-directed behavior that has the capacity to produce tissue injury. Different forms of self-injury (e.g. self-biting, self-hitting, head-banging) may partially segregate in specific neurodevelopmental disorders, although there is also significant overlap. For example, individuals with Prader-Willi syndrome typically pick at their skin, whereas those with Lesch-Nyhan syndrome bite themselves, while individuals with autism exhibit an array of self-injurious behaviors (self-hitting, self-biting, head-banging). Many individuals have "preferred" forms and target locations, and their self-injurious acts can be highly repetitive and stereotyped. Such structural characteristics can differ substantially between individuals even when they have the same genetic syndrome or type of neurodevelopmental disorder. Furthermore, self-injurious behavior (SIB) emerges in a variety of environmental contexts, and may be closely associated with impoverished institutional environments and/or emotional distress, suggesting that these may be common establishing conditions. It is worth noting that SIB is also seen in animals under a variety of circumstances, including laboratory models, domestic pets, and animals kept in zoos or farms. Thus, the etiology and expression of SIB is not unique to humans. Overall, these observations raise a variety of questions about the etiology and expression of self-injury. Do the various forms of self-injury represent the same or different phenomena across the different groups? Are there common underlying mechanisms, or does each pattern of SIB represent a distinct form of predisposing neuropathology? Because self-injury is prevalent across disparate diagnostic groups, is there reason to believe that perturbation of common biological mechanisms make it more likely that SIB will emerge? This question could be restated to ask whether risk factors (which seem to vary widely at the phenomenological level) are mediated through some common pathophysiological mechanism(s) such that biological vulnerabilities-regardless of diagnostic differences-can be identified to estimate developmental risk for SIB. The ultimate goal of a developmental account is to promote prevention in the form of risk reduction. Our specific purpose in writing this chapter is to selectively review the research evidence for "risk factors" that promote vulnerability for SIB specific to I/DD, and then suggest that our current approach to understanding SIB risk has been limited by relying for too long on conventional prevalence ratio study designs. We argue that adopting approaches informed from bench studies of risk factors may help move us forward faster in understanding which individuals with I/DD are likely to develop SIB and the circumstances under which it will most likely occur.
C1 [Devine, Darragh P.] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA.
   [Symons, Frank J.] Univ Minnesota, Dept Educ Psychol, Minneapolis, MN 55455 USA.
RP Symons, FJ (reprint author), Univ Minnesota, Dept Educ Psychol, Minneapolis, MN 55455 USA.
EM symon007@umn.edu
CR ANDO H, 1978, J ABNORM CHILD PSYCH, V6, P345, DOI 10.1007/BF00924737
   ANDO H, 1979, CHILD PSYCHIAT HUM D, V10, P85, DOI 10.1007/BF01433500
   Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301
   Archer DC, 2008, EQUINE VET J, V40, P405, DOI 10.2746/042516408X312149
   Arron K, 2011, J INTELL DISABIL RES, V55, P109, DOI 10.1111/j.1365-2788.2010.01337.x
   Baghdadli A, 2003, J INTELL DISABIL RES, V47, P622, DOI 10.1046/j.1365-2788.2003.00507.x
   Barerera F. J., 2007, BEHAV INTERVENT, V22, P5
   Barrera F. J., 1994, J DEV PHYS DISABIL, V6, P169, DOI 10.1007/BF02579358
   BARTAK L, 1976, J AUTISM CHILD SCHIZ, V6, P109, DOI 10.1007/BF01538054
   Beauchaine TP, 2009, DEV PSYCHOPATHOL, V21, P735, DOI 10.1017/S0954579409000418
   Beckett C, 2002, J DEV BEHAV PEDIATR, V23, P297
   Berkson G., 2002, SELF INJURIOUS BEHAV, P145, DOI 10.1037/10457-009
   Berkson G, 2001, AM J MENT RETARD, V106, P539, DOI 10.1352/0895-8017(2001)106<0539:EDOSAS>2.0.CO;2
   Berkson G, 2000, J EARLY INTERVENTION, V23, P1, DOI 10.1177/10538151000230010401
   BODFISH JW, 1995, AM J MENT RETARD, V100, P183
   Brahm NC, 2008, ANN PHARMACOTHER, V42, P131, DOI 10.1345/aph.1K427
   Breese GR, 2005, BRAIN RES REV, V48, P57, DOI 10.1016/j.brainresrev.2004.08.004
   BREESE GR, 1985, J PHARMACOL EXP THER, V235, P287
   BREESE GR, 1984, PHARMACOL BIOCHEM BE, V21, P459
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Cicchetti D, 2006, ANN NY ACAD SCI, V1094, P248, DOI 10.1196/annals.1376.029
   CLARKE DJ, 1989, J ROY SOC MED, V82, P21
   Cohen IL, 2010, J AUTISM DEV DISORD, V40, P599, DOI 10.1007/s10803-009-0908-z
   COID J, 1983, LANCET, V2, P545
   Cooper SA, 2009, J INTELL DISABIL RES, V53, P200, DOI 10.1111/j.1365-2788.2008.01060.x
   Cromwell HC, 1999, PHARMACOL BIOCHEM BE, V62, P223, DOI 10.1016/S0091-3057(98)00152-X
   Davenport MD, 2008, BIOL PSYCHIAT, V63, P990, DOI 10.1016/j.biopsych.2007.10.025
   Dellinger-Ness LA, 2006, CLIN PSYCHOL REV, V26, P503, DOI 10.1016/j.cpr.2006.03.004
   Devine D. P., 2012, PSYCHIAT DISORDERS M, P155
   Devine D. P., 2012, PSYCHIAT DISORDERS M, P65
   Devine D. P., 2009, SELBSTVERLETZENDES V, P39
   Dixon PM, 2005, VET J, V169, P165, DOI 10.1016/j.tvjl.2004.03.022
   DODMAN NH, 1988, J AM VET MED ASSOC, V193, P815
   DODMAN NH, 1994, J AM VET MED ASSOC, V204, P1219
   Dominick KC, 2007, RES DEV DISABIL, V28, P145, DOI 10.1016/j.ridd.2006.02.003
   Dufour-Rainfray D, 2011, NEUROSCI BIOBEHAV R, V35, P1254, DOI 10.1016/j.neubiorev.2010.12.013
   EDDY NB, 1965, B WORLD HEALTH ORGAN, V32, P721
   EDWARDS G, 1981, B WORLD HEALTH ORGAN, V59, P225
   FAVELL JE, 1982, BEHAV THER, V13, P529, DOI 10.1016/S0005-7894(82)80015-4
   Gal E, 2009, RES DEV DISABIL, V30, P342, DOI 10.1016/j.ridd.2008.06.003
   GENOVESE E, 1969, LIFE SCI PT 1 PHYSI, V8, P513, DOI 10.1016/0024-3205(69)90445-7
   GLUCK JP, 1974, J ABNORM PSYCHOL, V83, P331, DOI 10.1037/h0036584
   Goodall J, 1986, CHIMPANZEES GOMBE PA
   GUESS D, 1991, AM J MENT RETARD, V96, P299
   Hall S, 2001, AM J MENT RETARD, V106, P189, DOI 10.1352/0895-8017(2001)106<0189:EDOSIB>2.0.CO;2
   HARLOW HARRY F., 1962, SCI AMER, V207, P136
   HARLOW HF, 1965, P NATL ACAD SCI USA, V54, P90, DOI 10.1073/pnas.54.1.90
   Hessl D, 2008, J AUTISM DEV DISORD, V38, P184, DOI 10.1007/s10803-007-0365-5
   HOEFNAGE.D, 1968, FED PROC, V27, P1042
   Holcomb WL, 2001, OBSTET GYNECOL, V98, P685, DOI 10.1016/S0029-7844(01)01488-0
   Howlin P. A., 2011, SAGE HDB DEV DISORDE
   IGLAUER F, 1995, LAB ANIM, V29, P385, DOI 10.1258/002367795780740140
   IWATA BA, 1982, ANAL INTERVEN DEVEL, V2, P3, DOI 10.1016/0270-4684(82)90003-9
   JAN JE, 1994, DEV MED CHILD NEUROL, V36, P321
   Jenkins Jeffrey R., 2001, Veterinary Clinics of North America Exotic Animal Practice, V4, P651
   Kahng S, 2002, AM J MENT RETARD, V107, P212, DOI 10.1352/0895-8017(2002)107<0212:BTOSIT>2.0.CO;2
   Kahng S., 2002, SELF INJURIOUS BEHAV, P119, DOI 10.1037/10457-007
   KANNEL WB, 1961, ANN INTERN MED, V55, P33
   Kemp AS, 2008, PSYCHIAT RES, V157, P181, DOI 10.1016/j.psychres.2007.04.003
   Kennedy CH, 2002, SELF INJURIOUS BEHAV, P133, DOI 10.1037/10457-008
   Kies SD, 2004, PHARMACOL BIOCHEM BE, V79, P587, DOI 10.1016/j.pbh.2004.09.010
   King B H, 1993, J Child Adolesc Psychopharmacol, V3, P71, DOI 10.1089/cap.1993.3.71
   LAKIN KC, 1983, AM J MENT DEF, V88, P13
   LEWIS MH, 1990, BRAIN RES, V513, P67, DOI 10.1016/0006-8993(90)91089-Y
   Lindauer SE, 1999, J APPL BEHAV ANAL, V32, P103, DOI 10.1901/jaba.1999.32-103
   Lutz C, 2003, AM J PRIMATOL, V60, P1, DOI 10.1002/ajp.10075
   MARTIN LJ, 1991, J NEUROSCI, V11, P3344
   Matson JL, 1996, RES DEV DISABIL, V17, P135, DOI 10.1016/0891-4222(95)00044-5
   McClintock K, 2003, J INTELL DISABIL RES, V47, P405, DOI 10.1046/j.1365-2788.2003.00517.x
   McDonnell SM, 2008, ANIM REPROD SCI, V107, P219, DOI 10.1016/j.anireprosci.2008.04.012
   McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x
   Meyza K. Z., BEHAV BRAIN IN PRESS
   Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029
   Muehlmann A. M., 2008, KEYSTONE S IDENTIF C, VC2, P104
   Muehlmann AM, 2008, J PHARMACOL EXP THER, V324, P214, DOI 10.1124/jpet.107.128207
   Muehlmann AM, 2011, BEHAV BRAIN RES, V217, P148, DOI 10.1016/j.bbr.2010.10.012
   Muehlmann AM, 2012, J INTELL DISABIL RES, V56, P490, DOI 10.1111/j.1365-2788.2011.01485.x
   MUELLER K, 1982, PHARMACOL BIOCHEM BE, V17, P613, DOI 10.1016/0091-3057(82)90332-X
   MUELLER K, 1980, PHARMACOL BIOCHEM BE, V13, P627, DOI 10.1016/0091-3057(80)90003-9
   Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X
   Novak MA, 2003, AM J PRIMATOL, V59, P3, DOI 10.1002/ajp.10063
   Oliver C., 2011, J AUTISM DEV DISORD, V42, P910
   Oliver C., 2005, J INTELL DISABIL RES, V31, P147
   OReilly MF, 1997, J APPL BEHAV ANAL, V30, P165, DOI 10.1901/jaba.1997.30-165
   Patterson PH, 2011, PEDIATR RES, V69, p34R, DOI 10.1203/PDR.0b013e318212b80f
   Richman DM, 2008, J INTELL DISABIL RES, V52, P3, DOI 10.1111/j.1365-2788.2007.01027.x
   Richman DM, 2005, AM J MENT RETARD, V110, P439, DOI 10.1352/0895-8017(2005)110[439:LAOSPA]2.0.CO;2
   ROACH ES, 1985, NEUROPEDIATRICS, V16, P159, DOI 10.1055/s-2008-1059532
   ROBINSON TE, 1993, BRAIN RES REV, V18, P247, DOI 10.1016/0165-0173(93)90013-P
   ROJAHN J, 1984, J BEHAV ASSESS, V6, P13, DOI 10.1007/BF01321457
   RUSS MJ, 1992, BIOL PSYCHIAT, V32, P501, DOI 10.1016/0006-3223(92)90218-O
   Sandman CA, 2008, DEV PSYCHOBIOL, V50, P680, DOI 10.1002/dev.20323
   Sandman CA, 2003, AM J MENT RETARD, V108, P414, DOI 10.1352/0895-8017(2003)108<414:EAAADA>2.0.CO;2
   Sandman C.A., 1990, J CHILD ADOL PSYCHOP, V1, P237, DOI 10.1089/cap.1990.1.237
   Schroeder S. R., 2002, SELF INJURIOUS BEHAV, P41, DOI 10.1037/10457-003
   Schwartz S, 2002, J AM VET MED ASSOC, V220, P1028, DOI 10.2460/javma.2002.220.1028
   Schwartz S, 1996, J Am Vet Med Assoc, V208, P1813
   Schwartz S, 2003, J AM VET MED ASSOC, V222, P1526, DOI 10.2460/javma.2003.222.1526
   Shishido T, 2000, PHARMACOL BIOCHEM BE, V66, P579, DOI 10.1016/S0091-3057(00)00219-7
   SHODELL MJ, 1968, ARCH GEN PSYCHIAT, V19, P453
   Silverman J. L., 2011, NATURE REV NEUROSCIE, V11, P490
   SINGH NN, 1977, NEW ZEAL MED J, V86, P325
   SIVAM SP, 1995, BRAIN RES, V690, P259, DOI 10.1016/0006-8993(95)00604-O
   Snow J., 1855, MODE COMMUNICATION C, V2nd
   Sovner R., 1996, SEMINARS CLIN NEUROP, V1, P105
   Stodgell CJ, 1998, BRAIN RES, V783, P10, DOI 10.1016/S0006-8993(97)01128-1
   Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9
   Symons FJ, 2009, RES DEV DISABIL, V30, P521, DOI 10.1016/j.ridd.2008.07.012
   Symons FJ, 2005, J INTELL DISABIL RES, V49, P144, DOI 10.1111/j.1365-2788.2004.00632.x
   Symons FJ, 1997, J INTELL DISABIL RES, V41, P456, DOI 10.1111/j.1365-2788.1997.tb00737.x
   Symons FJ, 2003, AM J MENT RETARD, V108, P13, DOI 10.1352/0895-8017(2003)108<0013:ADPOSS>2.0.CO;2
   Symons FJ, 2009, BRAIN BEHAV IMMUN, V23, P365, DOI 10.1016/j.bbi.2008.11.003
   Symons FJ, 2010, J PAIN, V11, P773, DOI 10.1016/j.jpain.2009.11.011
   Symons FJ, 2008, PAIN, V134, P232, DOI 10.1016/j.pain.2007.07.022
   Symons FJ, 1999, AM J MENT RETARD, V104, P260, DOI 10.1352/0895-8017(1999)104<0260:SBAPSB>2.0.CO;2
   Symons FJ, 2011, NEUROSCI BIOBEHAV R, V35, P1266, DOI 10.1016/j.neubiorev.2011.01.002
   Symons F.S., 2002, SELF INJURIOUS BEHAV, P223, DOI 10.1037/10457-015
   Tiefenbacher S, 2000, PSYCHONEUROENDOCRINO, V25, P799, DOI 10.1016/S0306-4530(00)00027-5
   Tiefenbacher S, 2004, PSYCHONEUROENDOCRINO, V29, P501, DOI 10.1016/S0306-4530(03)00068-4
   Totsika V, 2008, J INTELL DISABIL RES, V52, P446, DOI 10.1111/j.1365-2788.2008.01046.x
   Tsiouris JA, 2003, J CLIN PSYCHIAT, V64, P1081
   Tsiouris JA, 2004, CNS DRUGS, V18, P687, DOI 10.2165/00023210-200418110-00001
   Turner CA, 2002, SELF INJURIOUS BEHAV, P165, DOI 10.1037/10457-011
   Verhoeven WMA, 1999, PHARMACOPSYCHIATRY, V32, P13, DOI 10.1055/s-2007-979183
   Viera AJ, 2008, SOUTH MED J, V101, P730, DOI 10.1097/SMJ.0b013e31817a7ee4
   Weisbrot DM, 2005, J CHILD ADOL PSYCHOP, V15, P477, DOI 10.1089/cap.2005.15.477
   Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104
   WINCHEL RM, 1991, AM J PSYCHIAT, V148, P306
   WISE RA, 1987, PSYCHOL REV, V94, P469, DOI 10.1037/0033-295X.94.4.469
   Woolf CJ, 2010, J CLIN INVEST, V120, P3742, DOI 10.1172/JCI45178
   Yamaoka J, 2007, J DERMATOL SCI, V46, P41, DOI 10.1016/j.jdermsci.2006.12.007
   YOUNG LD, 1973, AM J PSYCHIAT, V130, P400
   Zuo YX, 2003, PAIN, V105, P467, DOI 10.1016/S0304-3959(03)00261-6
NR 133
TC 1
Z9 1
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-401725-2
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 44
BP 37
EP 67
DI 10.1016/B978-0-12-401662-0.00002-6
PG 31
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BFQ02
UT WOS:000320926000003
ER

PT J
AU Oliver, C
   Adams, D
   Allen, D
   Bull, L
   Heald, M
   Moss, J
   Wilde, L
   Woodcock, K
AF Oliver, Chris
   Adams, Dawn
   Allen, Debbie
   Bull, Leah
   Heald, Mary
   Moss, Jo
   Wilde, Lucy
   Woodcock, Kate
BE Hastings, RP
   Rojahn, J
TI Causal Models of Clinically Significant Behaviors in Angelman, Cornelia
   de Lange, Prader-Willi and Smith-Magenis Syndromes
SO INTERNATIONAL REVIEW OF RESEARCH IN DEVELOPMENTAL DISABILITIES:
   CHALLENGING BEHAVIOR, VOL 44
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID SELF-INJURIOUS-BEHAVIOR; BRACHMANN-DELANGE SYNDROME; SYNDROME DEL
   17P11.2; DU-CHAT-SYNDROMES; GENOTYPE-PHENOTYPE CORRELATIONS; AUTISM
   SPECTRUM DISORDERS; FRAGILE-X-SYNDROME; COMPULSIVE BEHAVIOR;
   ENVIRONMENTAL EVENTS; GENETIC SUBTYPES
AB The operant learning theory account of behaviors of clinical significance in people with intellectual disability (ID) has dominated the field for nearly 50 years. However, in the last two decades, there has been a substantial increase in published research that describes the behavioral phenotypes of genetic disorders and shows that behaviors such as self-injury and aggression are more common in some syndromes than might be expected given group characteristics. These cross-syndrome differences in prevalence warrant explanation, not least because this observation challenges an exclusively operant learning theory account. To explore this possible conflict between theoretical account and empirical observation, we describe the genetic cause and physical, social, cognitive and behavioral phenotypes of four disorders associated with ID (Angleman, Cornelia de Lange, Prader-Willi and Smith-Magenis syndromes) and focus on the behaviors of clinical significance in each syndrome. For each syndrome we then describe a model of the interactions between physical characteristics, cognitive and motivational endophenotypes and environmental factors (including operant reinforcement) to account for the resultant behavioral phenotype. In each syndrome it is possible to identify pathways from gene to physical phenotype to cognitive or motivational endophenotype to behavior to environment and back to behavior. We identify the implications of these models for responsive and early intervention and the challenges for research in this area. We identify a pressing need for meaningful dialog between different disciplines to construct better informed models that can incorporate all relevant and robust empirical evidence.
C1 [Oliver, Chris; Adams, Dawn; Allen, Debbie; Bull, Leah; Heald, Mary; Moss, Jo; Wilde, Lucy; Woodcock, Kate] Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England.
   [Moss, Jo] UCL, Inst Cognit Neurosci, London, England.
   [Woodcock, Kate] Peking Univ, Culture & Social Cognit Neurosci Lab, Dept Psychol, Beijing 100871, Peoples R China.
RP Oliver, C (reprint author), Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England.
EM c.oliver@bham.ac.uk
RI Moss, Jo/C-8812-2009
CR Adams D, 2011, AM J MED GENET A, V155A, P1290, DOI 10.1002/ajmg.a.33964
   Allanson JE, 1999, J MED GENET, V36, P394
   Allen D, 2010, J INTELL DISABIL RES, V54, P885
   Allen KD, 2013, RES DEV DISABIL, V34, P676, DOI 10.1016/j.ridd.2012.10.001
   Arron K, 2011, J INTELL DISABIL RES, V55, P109, DOI 10.1111/j.1365-2788.2010.01337.x
   Oliver C, 2006, AM J MENT RETARD, V111, P184
   Atrigas-Pallares J., 2005, REV NEUROLOGIA, V41, P649
   Barry Raymond J, 2005, Am J Med Genet A, V132A, P8
   Basile E, 2007, J INTELL DISABIL RES, V51, P671, DOI 10.1111/j.1365-2788.2007.00977.x
   BAY C, 1993, AM J MED GENET, V47, P965, DOI 10.1002/ajmg.1320470706
   Beardsmore A, 1998, J INTELL DISABIL RES, V42, P463, DOI 10.1046/j.1365-2788.1998.4260463.x
   BECK B, 1985, ACTA PAEDIATR SCAND, V74, P765, DOI 10.1111/j.1651-2227.1985.tb10028.x
   Berg K., 2007, J POLICY PRACT INTEL, V4, P120, DOI DOI 10.1111/J.1741-1130.2007.00109.X
   Berney TP, 1999, ARCH DIS CHILD, V81, P333
   Bertella L, 2005, J INTELL DISABIL RES, V49, P159, DOI 10.1111/j.1365-2788.2004.00634.x
   Bhuiyan Z., 2005, J MED GENETICS
   Boer H, 2002, LANCET, V359, P135, DOI 10.1016/S0140-6736(02)07340-3
   Braam W, 2008, J CHILD NEUROL, V23, P649, DOI 10.1177/0883073808314153
   Brown WM, 2004, MED HYPOTHESES, V63, P377, DOI 10.1016/j.mehy.2004.05.010
   Bruni O, 2004, BRAIN DEV-JPN, V26, P233, DOI 10.1016/S0387-7604(03)00160-8
   Butler JV, 2002, DEV MED CHILD NEUROL, V44, P248, DOI 10.1017/S001216220100202X
   Cassidy SB, 2000, AM J MED GENET, V97, P136, DOI 10.1002/1096-8628(200022)97:2<136::AID-AJMG5>3.0.CO;2-V
   Cassidy SB, 2009, EUR J HUM GENET, V17, P3, DOI 10.1038/ejhg.2008.165
   Cassidy SB, 2012, GENET MED, V14, P10, DOI 10.1038/gim.0b013e31822bead0
   Chen K-S, 1996, MENTAL RETARD DEV DI, V2, P122, DOI 10.1002/(SICI)1098-2779(1996)2:3<122::AID-MRDD2>3.0.CO;2-U
   Cheron G, 2005, NEUROSCIENCE, V130, P631, DOI 10.1016/j.neuroscience.2004.09.013
   Clarke DJ, 1998, AM J MENT RETARD, V103, P264, DOI 10.1352/0895-8017(1998)103<0264:PBAWDP>2.0.CO;2
   Clarke DJ, 2000, AM J MENT RETARD, V105, P25, DOI 10.1352/0895-8017(2000)105<0025:PBAWQA>2.0.CO;2
   Clayton-Smith J, 2001, DEV MED CHILD NEUROL, V43, P476, DOI 10.1017/S0012162201000871
   COLLEY AF, 1990, J PAEDIATR CHILD H, V26, P17, DOI 10.1111/j.1440-1754.1990.tb02372.x
   Collis L, 2006, J INTELL DISABIL RES, V50, P792
   Collis L., 2008, J INTELL DISABIL RES, V52, P675
   Cotton SM, 2010, RES AUTISM SPECT DIS, V4, P490, DOI 10.1016/j.rasd.2009.11.006
   Crumley F., 1998, J AM ACAD CHILD ADOL, V37, P11
   Dagli A., 2012, MOL SYNDROMOL, V2, P100, DOI DOI 10.1159/000328837
   Dan B, 2003, NEUROPEDIATRICS, V34, P169
   Dan B, 2004, BRAIN DEV-JPN, V26, P389, DOI 10.1016/j.braindev.2003.12.002
   Deardorff MA, 2012, NATURE, V489, P313, DOI 10.1038/nature11316
   Deardorff MA, 2007, AM J HUM GENET, V80, P485, DOI 10.1086/511888
   De Leersnyder H, 2006, MOL CELL ENDOCRINOL, V252, P88, DOI 10.1016/j.mce.2006.03.043
   De Leersnyder H, 2003, J MED GENET, V40, P74, DOI 10.1136/jmg.40.1.74
   De Leersnyder H, 2001, J PEDIATR-US, V139, P111, DOI 10.1067/mpd.2001.115018
   Di Cicco M, 2001, INT J PEDIATR OTORHI, V59, P147, DOI 10.1016/S0165-5876(01)00475-X
   Didden R, 2006, J INTELL DISABIL RES, V50, P54, DOI 10.1111/j.1365-2788.2005.00731.x
   Dimitropoulos A, 2001, AM J MENT RETARD, V106, P39, DOI 10.1352/0895-8017(2001)106<0039:EOCBAT>2.0.CO;2
   Dimitropoulos A, 2006, RES DEV DISABIL, V27, P190, DOI 10.1016/j.ridd.2005.01.002
   Duker PC, 2002, J INTELL DISABIL RES, V46, P35, DOI 10.1046/j.1365-2788.2002.00355.x
   DUKER PC, 1993, J BEHAV THER EXP PSY, V24, P249, DOI 10.1016/0005-7916(93)90028-U
   Dykens EM, 2002, J CHILD PSYCHOL PSYC, V43, P343, DOI 10.1111/1469-7610.00025
   Dykens EM, 1997, J AUTISM DEV DISORD, V27, P203, DOI 10.1023/A:1025800126086
   Dykens EM, 1998, J INTELL DISABIL RES, V42, P481, DOI 10.1046/j.1365-2788.1998.4260481.x
   Einfeld SL, 2006, AM J MENT RETARD, V111, P193, DOI 10.1352/0895-8017(2006)111[193:MIPS]2.0.CO;2
   Elsea SH, 2008, EUR J HUM GENET, V16, P412, DOI 10.1038/sj.ejhg.5202009
   Feurer ID, 1998, J INTELL DISABIL RES, V42, P472, DOI 10.1046/j.1365-2788.1998.4260472.x
   Finucane B, 2001, AM J MENT RETARD, V106, P52, DOI 10.1352/0895-8017(2001)106<0052:COSIBI>2.0.CO;2
   Finucane B. M., 1994, DEV MED CHILD NEUROL, V36, P70
   Finucane B, 2009, J MENT HEALTH RES IN, V2, P134, DOI 10.1080/19315860802627619
   Gentile JK, 2010, J DEV BEHAV PEDIATR, V31, P592, DOI 10.1097/DBP.0b013e3181ee408e
   Gillis LA, 2004, AM J HUM GENET, V75, P610, DOI 10.1086/424698
   Gimigliano A, 2012, J PROTEOME RES, V11, P6111, DOI 10.1021/pr300760p
   Goldman SE, 2012, J INTELL DISABIL RES, V56, P600, DOI 10.1111/j.1365-2788.2011.01499.x
   GOODBAN MT, 1993, AM J MED GENET, V47, P1059, DOI 10.1002/ajmg.1320470725
   Greaves N, 2006, J INTELL DISABIL RES, V50, P92, DOI 10.1111/j.1365-2788.2005.00726.x
   Greenberg F, 1996, AM J MED GENET, V62, P247, DOI 10.1002/(SICI)1096-8628(19960329)62:3<247::AID-AJMG9>3.3.CO;2-9
   GREENBERG F, 1991, AM J HUM GENET, V49, P1207
   Griffith GM, 2011, J INTELL DISABIL RES, V55, P397, DOI 10.1111/j.1365-2788.2011.01386.x
   Gropman AL, 2006, PEDIATR NEUROL, V34, P337, DOI 10.1016/j.pediatrneurol.2005.08.018
   Gropman AL, 2007, CURR OPIN NEUROL, V20, P125, DOI 10.1097/WCO.0b013e3280895dba
   Gualtieri C. T., 1990, NEUROPSYCHIATRY BEHA
   Haas-Givler B., 1994, SPECTRUM NEWSLETTER, V1, P1
   Hagerman RJ, 1999, MENT RETARD DEV D R, V5, P305, DOI 10.1002/(SICI)1098-2779(1999)5:4<305::AID-MRDD8>3.0.CO;2-L
   Haig D, 2003, AM J HUM BIOL, V15, P320, DOI 10.1002/ajhb.10150
   Hall SS, 2008, J INTELL DISABIL RES, V52, P458, DOI 10.1111/j.1365-2788.2008.01047.x
   Harting I, 2009, EUR J PAEDIATR NEURO, V13, P271, DOI 10.1016/j.ejpn.2008.04.005
   HAWLEY PP, 1985, AM J MED GENET, V20, P453, DOI 10.1002/ajmg.1320200306
   Heald M, 2013, RES DEV DISABIL, V34, P1794, DOI 10.1016/j.ridd.2013.02.012
   Hodapp RM, 1998, J INTELL DISABIL RES, V42, P331, DOI 10.1046/j.1365-2788.1998.00148.x
   Holland A, 2003, LANCET, V362, P989, DOI 10.1016/S0140-6736(03)14370-X
   Holland AJ, 2003, PSYCHOL MED, V33, P141, DOI 10.1017/S0033291702006736
   Horsler K, 2006, AM J MENT RETARD, V111, P311, DOI 10.1352/0895-8017(2006)111[311:EIOTBP]2.0.CO;2
   Horsler K, 2006, J INTELL DISABIL RES, V50, P33, DOI 10.1111/j.1365-2788.2005.00730.x
   Hyman P, 2002, AM J MENT RETARD, V107, P146, DOI 10.1352/0895-8017(2002)107<0146:SIBSRA>2.0.CO;2
   Jauregi J, 2007, J INTELL DISABIL RES, V51, P350, DOI 10.1111/j.1365-2788.2006.00883.x
   JOHNSON HG, 1976, PEDIATR RES, V10, P843, DOI 10.1203/00006450-197610000-00006
   Kline AD, 2007, AM J MED GENET A, V143A, P1287, DOI 10.1002/ajmg.a.31757
   Kline AD, 2007, AM J MED GENET C, V145C, P248, DOI 10.1002/ajmg.c.30137
   KLINE AD, 1993, AM J MED GENET, V47, P1053, DOI 10.1002/ajmg.1320470724
   Koenig K, 2004, J AUTISM DEV DISORD, V34, P573, DOI 10.1007/s10803-004-2551-z
   Kraijer D, 2000, J AUTISM DEV DISORD, V30, P39, DOI 10.1023/A:1005460027636
   Laan LAEM, 1996, AM J MED GENET, V66, P356, DOI 10.1002/(SICI)1096-8628(19961218)66:3<356::AID-AJMG21>3.0.CO;2-K
   Laje G, 2010, AM J MED GENET C, V154C, P456, DOI 10.1002/ajmg.c.30275
   Langthorne P, 2008, AM J MENT RETARD, V113, P403, DOI 10.1352/2008.113:403-417
   Langthorne P, 2012, J AUTISM DEV DISORD, V42, P201, DOI 10.1007/s10803-011-1229-6
   Liu JL, 2008, ANNU REV GENOM HUM G, V9, P303, DOI 10.1146/annurev.genom.9.081307.164211
   Ludwig M, 2005, J MED GENET, V42, P289, DOI 10.1136/jmg.2004.026930
   Luzzani S, 2003, AM J MED GENET A, V119A, P283, DOI 10.1002/ajmg.a.20191
   Marchisio P, 2008, AM J MED GENET A, V146A, P426, DOI 10.1002/ajmg.a.32183
   Martin SC, 2006, J AUTISM DEV DISORD, V36, P541, DOI 10.1007/s10803-006-0093-2
   McAllister CJ, 2011, INT J OBESITY, V35, P188, DOI 10.1038/ijo.2010.139
   McCall C, 2012, NAT NEUROSCI, V15, P681, DOI 10.1038/nn.3084
   MENOLASCINO FJ, 1982, J MENT DEFIC RES, V26, P259
   Miller JL, 2007, J NEUROL NEUROSUR PS, V78, P615, DOI 10.1136/jnnp.2006.099044
   Milner KM, 2005, J CHILD PSYCHOL PSYC, V46, P1089, DOI 10.1111/j.1469-7610.2005.01520.x
   Moss J., 2011, OXFORD HDB INTELLECT, P275
   Moss J, 2012, J CHILD PSYCHOL PSYC, V53, P883, DOI 10.1111/j.1469-7610.2012.02540.x
   Moss J, 2009, J AUTISM DEV DISORD, V39, P572, DOI 10.1007/s10803-008-0655-6
   Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x
   Moss J, 2005, J INTELL DISABIL RES, V49, P269, DOI 10.1111/j.1365-2788.2005.00649.x
   Moss J., AM J INTELL IN PRESS
   Moss J, 2008, J INTELL DISABIL RES, V52, P657
   Moss JF, 2008, AM J MENT RETARD, V113, P278, DOI 10.1352/0895-8017(2008)113[278:POASPI]2.0.CO;2
   Mount R, 2011, J INTELL DISABIL RES, V55, P339, DOI 10.1111/j.1365-2788.2010.01364.x
   Musio A, 2006, NAT GENET, V38, P528, DOI 10.1038/ng1779
   Nakanishi M, 2012, AM J MED GENET A, V158A, P1841, DOI 10.1002/ajmg.a.34014
   Nallasamy S, 2006, ARCH OPHTHALMOL-CHIC, V124, P552, DOI 10.1001/archopht.124.4.552
   Nelson L., 2010, THESIS
   NYHAN WL, 1972, PEDIATR RES, V6, P1
   O'Brien G., 1995, BEHAV PHENOTYPES
   Oiglane-Shlik E, 2006, AM J MED GENET A, V140A, P1936, DOI 10.1002/ajmg.a.31423
   Oliver C, 2011, J AUTISM DEV DISORD, V41, P1019, DOI 10.1007/s10803-010-1125-5
   Oliver C, 2007, J CHILD PSYCHOL PSYC, V48, P571, DOI 10.1111/j.1469-7610.2007.01736.x
   Oliver C., 2007, AM J MED GENET A, V9999A, P1
   Oliver C, 2002, AM J MENT RETARD, V107, P194, DOI 10.1352/0895-8017(2002)107<0194:EOEEOS>2.0.CO;2
   Oliver C, 2008, BRIT J PSYCHIAT, V193, P466, DOI 10.1192/bjp.bp.107.044370
   OLIVER C, 1995, J CHILD PSYCHOL PSYC, V36, P909, DOI 10.1111/j.1469-7610.1995.tb01341.x
   OLIVER C, 1987, J MENT DEFIC RES, V31, P147
   Oliver C., 1993, CHALLENGING BEHAV LE, P135
   Oliver C, 2005, J INTELL DISABIL RES, V49, P591, DOI 10.1111/j.1365-2788.2005.00694.x
   OPITZ JM, 1985, AM J MED GENET, V22, P89, DOI 10.1002/ajmg.1320220110
   Ozonoff S, 1997, AUTISM EXECUTIVE DIS, P179
   Parvizi J, 2001, BRAIN, V124, P1708, DOI 10.1093/brain/124.9.1708
   Pelc Karine, 2008, Neuropsychiatr Dis Treat, V4, P577
   Peters SU, 2004, CLIN GENET, V66, P530, DOI 10.1111/j.1399-0004.2004.00362.x
   Peters SU, 2011, DEV MED CHILD NEUROL, V53, P361, DOI 10.1111/j.1469-8749.2010.03838.x
   Peters SU, 2012, J CHILD PSYCHOL PSYC, V53, P152, DOI 10.1111/j.1469-7610.2011.02455.x
   Petty J., 2005, CURRENT OPINION PSYC, V18, P467
   Potocki L, 2000, NAT GENET, V24, P84
   Radstaake M, 2012, DEV NEUROREHABIL, V15, P91, DOI 10.3109/17518423.2011.651537
   Reid D., 2010, THESIS
   Richards C, 2009, J AUTISM DEV DISORD, V39, P1155, DOI 10.1007/s10803-009-0730-7
   Roof E, 2000, J INTELL DISABIL RES, V44, P25, DOI 10.1046/j.1365-2788.2000.00250.x
   Rosner BA, 2004, J APPL RES INTELLECT, V17, P209, DOI 10.1111/j.1468-3148.2004.00200.x
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sahoo T, 2006, J MED GENET, V43, P512, DOI 10.1136/jmg.2005.036913
   SAITOH S, 1994, AM J MED GENET, V52, P158, DOI 10.1002/ajmg.1320520207
   Sanchez-Ortiga R, 2012, CLIN ENDOCRINOL, V77, P86, DOI 10.1111/j.1365-2265.2011.04303.x
   Sandanam T, 1997, AM J MED GENET, V70, P415, DOI 10.1002/(SICI)1096-8628(19970627)70:4<415::AID-AJMG16>3.0.CO;2-K
   Sarimski K, 1997, J INTELL DISABIL RES, V41, P70, DOI 10.1111/j.1365-2788.1997.tb00678.x
   Sarimski K, 2004, GENET COUNSEL, V15, P347
   SCHACHAR R, 1990, DEV PSYCHOL, V26, P710, DOI 10.1037/0012-1649.26.5.710
   Selicorni A, 2005, AM J MED GENET A, V132A, P395, DOI 10.1002/ajmg.a.30445
   Siemensma EPC, 2012, J CLIN ENDOCR METAB, V97, P2307, DOI 10.1210/jc.2012-1182
   SINGH NN, 1979, J MENT DEFIC RES, V23, P79
   Slager RE, 2003, NAT GENET, V33, P466, DOI 10.1038/ng1126
   Sloneem J, 2009, J INTELL DISABIL RES, V53, P590, DOI 10.1111/j.1365-2788.2009.01183.x
   Sloneem J, 2011, J INTELL DISABIL RES, V55, P138, DOI 10.1111/j.1365-2788.2010.01371.x
   Smith A, 1996, J MED GENET, V33, P107, DOI 10.1136/jmg.33.2.107
   SMITH ACM, 1986, AM J MED GENET, V24, P393, DOI 10.1002/ajmg.1320240303
   Smith ACM, 1998, AM J MED GENET, V81, P179, DOI 10.1002/(SICI)1096-8628(19980328)81:2<179::AID-AJMG10>3.0.CO;2-E
   Smith J C, 2001, Dev Med Child Neurol, V43, P476
   Solomon BI, 2002, AM J HUM GENET, V71, P271
   Soni S, 2007, J INTELL DISABIL RES, V51, P32, DOI 10.1111/j.1365-2788.2006.00895.x
   SONUGABARKE EJS, 1992, J CHILD PSYCHOL PSYC, V33, P1091, DOI 10.1111/j.1469-7610.1992.tb00927.x
   SONUGABARKE EJS, 1992, J CHILD PSYCHOL PSYC, V33, P387, DOI 10.1111/j.1469-7610.1992.tb00874.x
   Sonuga-Barke EJS, 2002, BEHAV BRAIN RES, V130, P29, DOI 10.1016/S0166-4328(01)00432-6
   Stauder JEA, 2002, NEUROSCI LETT, V327, P99, DOI 10.1016/S0304-3940(02)00377-4
   Strachan R, 2009, RES DEV DISABIL, V30, P1095, DOI 10.1016/j.ridd.2009.03.005
   Summers JA, 1999, AM J MENT RETARD, V104, P376, DOI 10.1352/0895-8017(1999)104<0376:DPOBFI>2.0.CO;2
   SUMMERS JA, 1995, J INTELL DISABIL RES, V39, P97
   SWAAB DF, 1995, J CLIN ENDOCR METAB, V80, P573, DOI 10.1210/jc.80.2.573
   Tan WH, 2011, AM J MED GENET A, V155A, P81, DOI 10.1002/ajmg.a.33775
   Tauber M., 2012, ORPHANET J RARE DIS, V6, P47
   Taylor L, 2008, J INTELL DISABIL RES, V52, P830, DOI 10.1111/j.1365-2788.2008.01066.x
   Tonkin ET, 2004, NAT GENET, V36, P636, DOI 10.1038/ng1363
   Trillingsgaard A, 2004, AUTISM, V8, P163, DOI 10.1177/1362361304042720
   Tunnicliffe P, 2011, RES DEV DISABIL, V32, P404, DOI 10.1016/j.ridd.2010.12.008
   Tunnicliffe P., J INTELLECT IN PRESS
   Turner M. A., 1997, AUTISM EXECUTIVE DIS, P57
   Udwin O, 2001, DEV MED CHILD NEUROL, V43, P823, DOI 10.1017/S0012162201001499
   Van Buggenhout G, 2009, EUR J HUM GENET, V17, P1367, DOI 10.1038/ejhg.2009.67
   van Woerden GM, 2007, NAT NEUROSCI, V10, P280, DOI 10.1038/nn1845
   Varela MC, 2004, EUR J HUM GENET, V12, P987, DOI 10.1038/sj.ejhg.5201264
   Veltman MWM, 2005, PSYCHIAT GENET, V15, P243, DOI 10.1097/00041444-200512000-00006
   VOLLMER TR, 1995, J APPL BEHAV ANAL, V28, P15, DOI 10.1901/jaba.1995.28-15
   Walz N. C., 2006, J AUTISM DEV DISORD, V37, P940
   Walz NC, 2006, AM J OCCUP THER, V60, P472
   Walz NC, 2002, J DEV PHYS DISABIL, V14, P307, DOI 10.1023/A:1020326701399
   Webber C., 1999, THESIS U LEICESTER
   Whittington J, 2004, J INTELL DISABIL RES, V48, P172, DOI 10.1111/j.1365-2788.2004.00556.x
   Whittington J, 2002, J MED GENET, V39, P926, DOI 10.1136/jmg.39.12.926
   Whittington J, 2011, J INTELL DISABIL RES, V55, P75, DOI 10.1111/j.1365-2788.2010.01348.x
   Whittington JE, 2001, J MED GENET, V38, P792, DOI 10.1136/jmg.38.11.792
   Wigren M, 2003, J INTELL DISABIL RES, V47, P428, DOI 10.1046/j.1365-2788.2003.00515.x
   Williams CA, 2006, AM J MED GENET A, V140A, P413, DOI 10.1002/ajmg.a.31074
   Williams C.A., 2001, AM J MED GENET, V101, P50
   Wilson BJ, 2011, PEDIATR NEUROL, V44, P350, DOI 10.1016/j.pediatrneurol.2010.12.002
   Woodcock K, 2009, J INTELL DISABIL RES, V53, P265, DOI 10.1111/j.1365-2788.2008.01122.x
   Woodcock KA, 2009, COGN NEUROPSYCHOL, V26, P172, DOI 10.1080/02643290802685921
   Woodcock KA, 2011, J INTELL DISABIL RES, V55, P152, DOI 10.1111/j.1365-2788.2010.01368.x
   Woodcock KA, 2009, NEUROPSYCHOLOGIA, V47, P2367, DOI 10.1016/j.neuropsychologia.2008.09.019
   Woodcock KA, 2010, BRAIN RES, V1363, P128, DOI 10.1016/j.brainres.2010.09.093
   Woodcock KA, 2009, J INTELL DISABIL RES, V53, P493, DOI 10.1111/j.1365-2788.2009.01167.x
   Zarcone J, 2007, J INTELL DISABIL RES, V51, P478, DOI 10.1111/j.1365-2788.2006.00916.x
NR 203
TC 3
Z9 3
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-401725-2
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 44
BP 167
EP 211
DI 10.1016/B978-0-12-401662-0.00006-3
PG 45
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BFQ02
UT WOS:000320926000007
ER

PT J
AU McIntyre, LL
AF McIntyre, Laura Lee
BE Hastings, RP
   Rojahn, J
TI Parent Training Interventions to Reduce Challenging Behavior in Children
   with Intellectual and Developmental Disabilities
SO INTERNATIONAL REVIEW OF RESEARCH IN DEVELOPMENTAL DISABILITIES:
   CHALLENGING BEHAVIOR, VOL 44
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID RANDOMIZED CONTROLLED-TRIAL; YOUNG-CHILDREN; CONDUCT PROBLEMS;
   MENTAL-HEALTH; DECREASES AGGRESSION; ANTISOCIAL-BEHAVIOR; AUTISM
   SPECTRUM; SUPPORT PROGRAM; MUSIC-THERAPY; SCHOOL-AGE
AB It is well established that parents and other caregivers play an important role in shaping child development. Given the important link between parenting and child adjustment, a variety of parent management training interventions have been adopted from the disruptive behavior disorder treatment literature and applied to the prevention and treatment of challenging behavior in children with intellectual and developmental - disabilities (IDD). This chapter reviews empirical studies published from 2003 to 2012 that examine the effects of parent training interventions on challenging behavior of children with IDD. Nineteen studies representing 11 parent training programs are reviewed. Parent training interventions include the Incredible Years, Stepping Stones Triple P, Signposts for Building Better Behavior, Research Units in Pediatric Psychopharmacology Parent Training, Sing and Grow Music Therapy, Mindfulness Training, Parent-Child Interaction Therapy, the Autism Spectrum Conditions-Enhancing Nurture and Development program, Parent Training for Smaller Groups and Shorter Schedules, video modeling and feedback parent training, and parent management training. Taken together, results from these studies suggest a growing evidence base for the use of parent training interventions for reducing challenging behavior in children with IDD. Results suggest a smaller body of evidence for effects of parent training interventions on altering parenting behavior and enhancing parent mental health. Questions remain about the durability and generalization of findings, moderators and mediators of change, and strategies for enhancing therapeutic alliance and engagement with an aim to reduce attrition.
C1 Univ Oregon, Dept Special Educ & Clin Sci, Eugene, OR 97403 USA.
RP McIntyre, LL (reprint author), Univ Oregon, Dept Special Educ & Clin Sci, Eugene, OR 97403 USA.
EM llmcinty@uoregon.edu
CR Abad V., 2002, ANN NZ SOC MUSIC THE, P36
   Abidin RR, 1995, PARENTING STRESS IND
   Achenbach T. M., 2001, MANUAL ASEA PRESCHOO
   Aman MG, 2009, J AM ACAD CHILD PSY, V48, P1143, DOI 10.1097/CHI.0b013e3181bfd669
   AMAN MG, 1985, AM J MENT DEF, V89, P485
   Arnold D., 1993, PSYCHOL ASSESSMENT, V5, P137, DOI DOI 10.1037/1040-3590.5.2.137
   Arnold LE, 2000, J AUTISM DEV DISORD, V30, P99, DOI 10.1023/A:1005451304303
   Bagner DM, 2010, J DEV BEHAV PEDIATR, V31, P209, DOI 10.1097/DBP.0b013e3181d5a294
   Baker BL, 2002, AM J MENT RETARD, V107, P433, DOI 10.1352/0895-8017(2002)107<0433:BPAPSI>2.0.CO;2
   Baker BL, 2003, J INTELL DISABIL RES, V47, P217, DOI 10.1046/j.1365-2788.2003.00484.x
   Baker JK, 2007, AM J MENT RETARD, V112, P375, DOI 10.1352/0895-8017(2007)112[0375:POSSIY]2.0.CO;2
   Barkley R., 1999, DEFIANT TEENS CLIN M
   Barkley R. A., 1987, DEFIANT CHILDREN CLI
   Batshaw M. L., 2007, CHILDREN DISABILITIE, P245
   Baumrind D, 1989, CHILD DEV TODAY TOMO, P349
   Bronson M. B., 2000, SELF REGULATION EARL
   Brookman-Frazee L, 2006, CLIN CHILD FAM PSYCH, V9, P181, DOI 10.1007/s10567-006-0010-4
   Campbell D. T., 1963, EXPT QUASIEXPERIMENT
   Canitano Roberto, 2008, Neuropsychiatr Dis Treat, V4, P723
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Crnic K, 2009, INT REV RES MENT RET, V37, P3, DOI 10.1016/S0074-7750(09)37001-9
   Dishion T. J., 2007, INTERVENING CHILDREN
   DONENBERG G, 1993, J ABNORM CHILD PSYCH, V21, P179, DOI 10.1007/BF00911315
   Einfeld S. L., 2002, MANUAL DEV BEHAV CHE
   Einfeld SL, 2006, JAMA-J AM MED ASSOC, V296, P1981, DOI 10.1001/jama.296.16.1981
   Eisenhower AS, 2007, J SCHOOL PSYCHOL, V45, P363, DOI 10.1016/j.jsp.2006.10.002
   Emerson E, 2003, J INTELL DISABIL RES, V47, P51, DOI 10.1046/j.1365-2788.2003.00464.x
   Emerson E, 2010, AJIDD-AM J INTELLECT, V115, P30, DOI 10.1352/1944-7558-115.1.30
   Ercan E. S., 2012, J ATTENTION DISORDER
   Eyberg S., 1995, PSYCHOPHARMACOLOGY B, V3, P83
   Eyberg S., 1993, PROFESSIONAL RESOURC, V12, P377
   Eyberg S. M., 2005, MANUAL DYADIC PARENT
   Farmer C, 2012, J AUTISM DEV DISORD, V42, P1037, DOI 10.1007/s10803-011-1338-2
   Floyd FJ, 2004, AM J MENT RETARD, V109, P507, DOI 10.1352/0895-8017(2004)109<507:FPWCWH>2.0.CO;2
   Frost L., 2002, PICTURE EXCHANGE COM, V2nd
   Furukawa TA, 2003, PSYCHOL MED, V33, P357, DOI 10.1017/S0033291702006700
   GARDNER FEM, 1989, J ABNORM CHILD PSYCH, V17, P223, DOI 10.1007/BF00913796
   Gavidia-Payne S., 1997, 121 ANN M AM ASS MEN
   Gray C., 1994, COMIC STRIP CONVERSA
   Gray C., 1994, NEW SOCIAL STORY BOO
   Gray C.A., 1998, ASPERGER SYNDROME HI, P167
   Hames A., 2009, ED CHILD PSYCHOL, V26, P47
   Hastings RP, 2006, AM J MENT RETARD, V111, P48, DOI 10.1352/0895-8017(2006)111[48:MDAEEC]2.0.CO;2
   Himle MB, 2004, PEDIATRICS, V113, P70, DOI 10.1542/peds.113.1.70
   Hudson A., 2001, REPORT DEP HUMAN SER
   Hudson A, 2008, J INTELLECT DEV DIS, V33, P117, DOI 10.1080/13668250802065885
   Hudson A, 2009, J INTELLECT DEV DIS, V34, P123, DOI 10.1080/13668250902850426
   Hudson AM, 2003, J INTELL DISABIL RES, V47, P238, DOI 10.1046/j.1365-2788.2003.00486.x
   Ingoldsby EM, 2001, DEV PSYCHOPATHOL, V13, P35, DOI 10.1017/S0954579401001031
   Institut de la Statistique du Quebec, 2000, LONG STUD CHILD DEV, V1
   JACOBSON NS, 1991, J CONSULT CLIN PSYCH, V59, P12, DOI 10.1037//0022-006X.59.1.12
   Johnson CR, 2007, BEHAV INTERVENT, V22, P201, DOI 10.1002/bin.237
   JOHNSTON C, 1989, J CLIN CHILD PSYCHOL, V18, P167, DOI 10.1207/s15374424jccp1802_8
   Kabat-Zinn M., 1997, EVERYDAY BLESSINGS I
   Keen D, 2010, RES AUTISM SPECT DIS, V4, P229, DOI 10.1016/j.rasd.2009.09.009
   Kleve L., 2010, CLIN CHILD PSYCHOL P, V16, P253
   Kumpfer KL, 2003, AM PSYCHOL, V58, P457, DOI 10.1037/0003-066X.58.6-7.457
   LOVIBOND PF, 1995, BEHAV RES THER, V33, P335, DOI 10.1016/0005-7967(94)00075-U
   Martin J., 1981, MONOGRAPHS SOC RES C, V46
   Mcintyre LL, 2007, J APPL BEHAV ANAL, V40, P659, DOI 10.1901/jaba.2007.659-672
   McIntyre LL, 2008, J INTELL DISABIL RES, V52, P1176, DOI 10.1111/j.1365-2788.2008.01108.x
   McIntyre LL, 2006, J INTELL DISABIL RES, V50, P349, DOI 10.1111/j.1365-2788.2006.00783.x
   McIntyre LL, 2008, AM J MENT RETARD, V113, P356, DOI 10.1352/2008.113:356-368
   Nicholson JM, 2008, J HEALTH PSYCHOL, V13, P226, DOI 10.1177/1359105307086705
   Okuno H, 2011, BRAIN DEV-JPN, V33, P152, DOI 10.1016/j.braindev.2010.03.007
   Partington J. W., 1998, ASSESSMENT BASIC LAN
   Paterson G, 1999, SOC DEV, V8, P293, DOI 10.1111/1467-9507.00097
   Patterson G. R., 1982, SOCIAL LEARNING APPR, V3
   Patterson G. R., 1992, ANTISOCIAL BOYS
   PATTERSON GR, 1989, AM PSYCHOL, V44, P329, DOI 10.1037//0003-066X.44.2.329
   Phaneuf L, 2011, J POSIT BEHAV INTERV, V13, P198, DOI 10.1177/1098300711405337
   Phaneuf L, 2007, J APPL BEHAV ANAL, V40, P737, DOI 10.1901/jaba.2007.737-741
   Pillay Mini, 2011, Clin Child Psychol Psychiatry, V16, P5, DOI 10.1177/1359104509340945
   Pincus D., 1999, EYBERG CHILD BEHAV I
   Plant KM, 2007, RES DEV DISABIL, V28, P362, DOI 10.1016/j.ridd.2006.02.009
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Research Units on Pediatric Psychopharmacology (RUPP) Autism Network, 2007, BEHAV INTERV, V22, P179
   Russell A, 1996, INT J BEHAV DEV, V19, P291
   Sanders M. R., 1996, REVISED FAMILY OBSER
   Sanders M R, 1999, Clin Child Fam Psychol Rev, V2, P71, DOI 10.1023/A:1021843613840
   Sanders MR, 1993, BEHAV FAMILY INTERVE
   Scahill L, 2012, J AM ACAD CHILD PSY, V51, P136, DOI 10.1016/j.jaac.2011.11.010
   SHARPLEY CF, 1984, EDUC PSYCHOL MEAS, V44, P1045, DOI 10.1177/0013164484444029
   SHAW DS, 1993, J ABNORM CHILD PSYCH, V21, P493, DOI 10.1007/BF00916316
   Shaw DS, 2005, J CHILD PSYCHOL PSYC, V46, P931, DOI 10.1111/j.1469-7610.2004.00390.x
   Shaw DS, 2003, DEV PSYCHOL, V39, P189, DOI 10.1037/0012-1649.39.2.189
   Singh NN, 2006, J EMOT BEHAV DISORD, V14, P169, DOI 10.1177/10634266060140030401
   Singh NN, 2007, BEHAV MODIF, V31, P749, DOI 10.1177/0145445507300924
   Sofronoff K, 2004, AUTISM, V8, P301, DOI 10.1177/136261304045215
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Spence S. H., 1995, SOCIAL SKILLS TRAINI
   SRI International, 2003, NAT EARL INT LONG ST
   Stanley MA, 1998, OBSESSIVE-COMPULSIVE DISORDER, P277
   Stormshak EA, 2000, J CLIN CHILD PSYCHOL, V29, P17, DOI 10.1207/S15374424jccp2901_3
   Thompson S. J., 2007, CONT FAMILY THERAPY, V29, P39, DOI DOI 10.1007/S10591-007-9030-6
   Tonge B, 2006, J AM ACAD CHILD PSY, V45, P561, DOI 10.1097/01.chi.0000205701.48324.26
   Webster- Stratton C., 2001, INCREDIBLE YEARS PAR
   Webster-Stratton C., 2000, OFFICE JUVENILE JUST, P1
   Webster-Stratton C., 2005, INCREDIBLE YEARS TRO
   Whittingham K, 2009, J ABNORM CHILD PSYCH, V37, P469, DOI 10.1007/s10802-008-9285-x
   Williams KE, 2012, J MUSIC THER, V49, P23
   Wright B., 2007, INTERVENTIONS SUPPOR
NR 102
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-401725-2
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 44
BP 245
EP 279
DI 10.1016/B978-0-12-401662-0.00008-7
PG 35
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BFQ02
UT WOS:000320926000009
ER

PT J
AU Farmer, CA
   Aman, MG
AF Farmer, Cristan A.
   Aman, Michael G.
BE Hastings, RP
   Rojahn, J
TI Pharmacological Intervention for Disruptive Behaviors in Intellectual
   and Developmental Disabilities: The Glass is Half Full
SO INTERNATIONAL REVIEW OF RESEARCH IN DEVELOPMENTAL DISABILITIES:
   CHALLENGING BEHAVIOR, VOL 44
SE International Review of Research in Developmental Disabilities
LA English
DT Article; Book Chapter
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS;
   PSYCHOTROPIC MEDICATION USE; OPEN-LABEL TRIAL; SELF-INJURIOUS-BEHAVIOR;
   PRADER-WILLI-SYNDROME; MENTAL-RETARDATION; DOUBLE-BLIND; RETROSPECTIVE
   ASSESSMENT; SUBAVERAGE INTELLIGENCE
AB The use of psychotropic medicine for the treatment of disruptive behaviors such as irritability, attention-deficit hyperactivity disorder symptoms, and self-injury is more common in individuals with intellectual and developmental disabilities (IDD) than in neurotypical populations. With the exception of some atypical antipsychotics, few drugs carry clinical indications for such use. Thus, many children and adults with IDD receive "off-label" medication with varying degrees of empirical support for safety and efficacy. In this chapter, we review the literature on pharmacologic treatment of disruptive behavior in IDD between 2001 and 2010. We discuss several drug classes, including antipsychotics, antidepressants, psychostimulants, norepinephrine reuptake inhibitors, anticonvulsants, and glutamatergic agents. Due to the relative preponderance of research in samples with autism spectrum disorders, we present these separately from studies in general IDD samples. Overall, the research base is strongest for atypical antipsychotics and psychostimulants, and it is clear that the field has advanced between 2001 and 2010. Other drug classes have received relatively little research attention. We identify several areas in which the field can improve future research, including the study of combination treatments (e.g. cotherapy and medication plus behavioral).
C1 [Farmer, Cristan A.] NIMH, Pediat & Dev Neurosci Branch, Bethesda, MD 20892 USA.
   [Aman, Michael G.] Ohio State Univ, Nisonger Ctr UCEDD, Columbus, OH 43210 USA.
RP Farmer, CA (reprint author), NIMH, Pediat & Dev Neurosci Branch, Bethesda, MD 20892 USA.
EM farmerca@mail.nih.gov
CR Albertini G, 2006, PEDIATR NEUROL, V34, P417, DOI 10.1016/j.pediatrneurol.2005.10.023
   ALTMAN DG, 1995, BRIT MED J, V310, P298
   Aman M., 2002, CHILD ADOL PSYCH CL, V7, P1, DOI 10.1521/capn.7.5.1.22725
   Aman MG, 1999, MENT RETARD DEV D R, V5, P253, DOI 10.1002/(SICI)1098-2779(1999)5:4<253::AID-MRDD2>3.0.CO;2-R
   AMAN MG, 1985, AM J MENT DEF, V89, P485
   Aman MG, 2008, J CHILD ADOL PSYCHOP, V18, P227, DOI 10.1089/cap.2007.0133
   Aman MG, 2002, AM J PSYCHIAT, V159, P1337, DOI 10.1176/appi.ajp.159.8.1337
   Aman MG, 2000, EUR CHILD ADOLES PSY, V9, P98
   Aman MG, 2000, J AUTISM DEV DISORD, V30, P451, DOI 10.1023/A:1005559725475
   Aman MG, 2009, RES DEV DISABIL, V30, P386, DOI 10.1016/j.ridd.2008.07.004
   Amminger GP, 2007, BIOL PSYCHIAT, V61, P551, DOI 10.1016/j.biopsych.2006.05.007
   Amore M, 2011, J INTELL DISABIL RES, V55, P210, DOI 10.1111/j.1365-2788.2010.01352.x
   Antochi R, 2003, POSTGRAD MED J, V79, P139, DOI 10.1136/pmj.79.929.139
   Arnold LE, 2006, J AM ACAD CHILD PSY, V45, P1196, DOI 10.1097/01.chi.0000231976.28719.2a
   Baumeister A., 1998, PSYCHOTROPIC MED DEV, P133
   Bezchlibnyk-Butler KZ, 2005, CLIN HDB PSYCHOTROPI
   Blankenship K, 2011, J CHILD ADOL PSYCHOP, V21, P287, DOI 10.1089/cap.2010.0057
   Bramble D, 2007, J PSYCHOPHARMACOL, V21, P486, DOI 10.1177/0269881106075642
   Canitano R, 2005, BRAIN DEV-JPN, V27, P228, DOI 10.1016/j.braindev.2004.06.006
   Carminati GG, 2006, PROG NEURO-PSYCHOPH, V30, P312, DOI 10.1016/j.pnpbp.2005.10.002
   Charnsil C, 2011, J ATTEN DISORD, V15, P684, DOI 10.1177/1087054710376907
   Chez MG, 2007, J CHILD NEUROL, V22, P574, DOI 10.1177/0883073807302611
   Cohen S, 2003, J CLIN PSYCHIAT, V64, P60
   Corson AH, 2004, J CLIN PSYCHIAT, V65, P1531
   Coskun M, 2009, J CHILD ADOL PSYCHOP, V19, P203, DOI 10.1089/cap.2008.020
   Coskun M, 2008, J CHILD ADOL PSYCHOP, V18, P206, DOI 10.1089/cap.2007.0014
   Couturier JL, 2002, J CHILD ADOL PSYCHOP, V12, P243, DOI 10.1089/104454602760386932
   Croonenberghs J, 2005, J AM ACAD CHILD PSY, V44, P64, DOI 10.1097/01.chi.0000145805.24274.09
   de Bildt A, 2006, PEDIATRICS, V118, pE1860, DOI 10.1542/peds.2005-3101
   Devapriam J, 2008, BRIT J DEV DISABIL, V54, P11
   Di Martino A, 2004, J CHILD ADOL PSYCHOP, V14, P207, DOI 10.1089/1044546041649011
   Doyle CA, 2012, EXPERT OPIN PHARMACO, V13, P1615, DOI 10.1517/14656566.2012.674110
   Duggal HS, 2007, J CHILD ADOL PSYCHOP, V17, P261, DOI 10.1089/cap.2006.00136
   Erickson CA, 2009, J AUTISM DEV DISORD, V39, P1629, DOI 10.1007/s10803-009-0807-3
   Erickson CA, 2006, J CLIN PSYCHIAT, V67, P1000
   Erickson CA, 2011, PSYCHOPHARMACOLOGY, V216, P85, DOI 10.1007/s00213-011-2194-7
   Farmer Cristan A, 2011, Child Adolesc Psychiatry Ment Health, V5, P36, DOI 10.1186/1753-2000-5-36
   Farmer CA, 2009, RES DEV DISABIL, V30, P1155, DOI 10.1016/j.ridd.2009.03.001
   Findling RL, 2004, J CHILD ADOL PSYCHOP, V14, P287, DOI 10.1089/1044546041649129
   Findling RL, 2004, AM J PSYCHIAT, V161, P677, DOI 10.1176/appi.ajp.161.4.677
   Ghaleiha A, 2012, INT J NEUROPSYCHOPH, P1, DOI DOI 10.1017/S1461145712000880
   Goforth HW, 2003, AUST NZ J PSYCHIAT, V37, P775, DOI 10.1111/j.1440-1614.2003.01279.x
   Golubchik P, 2011, CLIN NEUROPHARMACOL, V34, P216, DOI 10.1097/WNF.0b013e31823349ac
   Greenhill LL, 2001, J AM ACAD CHILD PSY, V40, P180, DOI 10.1097/00004583-200102000-00012
   Haessler F, 2007, BRIT J PSYCHIAT, V190, P447, DOI 10.1192/bjp.bp.105.016535
   Handen BL, 2008, J DEV BEHAV PEDIATR, V29, P303, DOI 10.1097/DBP.0b013e3181739b9d
   Handen BL, 2006, J AM ACAD CHILD PSY, V45, P928, DOI 10.1097/01.chi.0000223312.48406.6e
   Handen BL, 2006, J CHILD PSYCHOL PSYC, V47, P871, DOI 10.1111/j.1469-7610.2006.01588.x
   Hardan AY, 2004, J CHILD ADOL PSYCHOP, V14, P426, DOI 10.1089/1044546042389082
   Hardan AY, 2005, J AUTISM DEV DISORD, V35, P387, DOI 10.1007/s10803-005-3306-1
   Hardan AY, 2012, BIOL PSYCHIAT, V71, P956, DOI 10.1016/j.biopsych.2012.01.014
   Hassler F, 2011, PHARMACOPSYCHIATRY, V44, P339, DOI 10.1055/s-0031-1291174
   Hassler F, 2008, PHARMACOPSYCHIATRY, V41, P232, DOI 10.1055/s-0028-1082072
   Hellings JA, 2006, J AUTISM DEV DISORD, V36, P401, DOI 10.1007/s10803-006-0078-1
   Hellings JA, 2005, J CHILD ADOL PSYCHOP, V15, P682, DOI 10.1089/cap.2005.15.682
   Holden B, 2004, RES DEV DISABIL, V25, P509, DOI 10.1016/j.ridd.2004.03.004
   Hollander E, 2006, J CHILD ADOL PSYCHOP, V16, P541, DOI 10.1089/cap.2006.16.541
   Hollander E, 2010, NEUROPSYCHOPHARMACOL, V35, P990, DOI 10.1038/npp.2009.202
   Jafferany M., 2010, PRIMARY CARE COMPANI, V12
   Janowsky DS, 2005, INT J NEUROPSYCHOPH, V8, P37, DOI 10.1017/S146114570400481X
   Janowsky DS, 2003, J CLIN PSYCHOPHARM, V23, P500, DOI 10.1097/01.jcp.0000088906.24613.76
   Janowsky DS, 2003, J CLIN PSYCHIAT, V64, P1258
   Jou RJ, 2005, J CHILD ADOL PSYCHOP, V15, P325, DOI 10.1089/cap.2005.15.325
   Kemner C, 2002, J CLIN PSYCHOPHARM, V22, P455, DOI 10.1097/01.jcp.0000033400.43191.6f
   King BH, 2002, CURR OPIN PSYCHIATR, V15, P497, DOI 10.1097/00001504-200209000-00006
   King BH, 2001, J AM ACAD CHILD PSY, V40, P658, DOI 10.1097/00004583-200106000-00010
   King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30
   Kowalski JL, 2011, J CHILD ADOL PSYCHOP, V21, P491, DOI 10.1089/cap.2011.0035
   Lambrey S, 2010, J CHILD ADOL PSYCHOP, V20, P79, DOI 10.1089/cap.2009.0057
   Lecavalier L, 2012, CAN J PSYCHIAT, V57, P585
   Malone RP, 2007, J CHILD ADOL PSYCHOP, V17, P779, DOI 10.1089/cap.2006.0126
   Mandell DS, 2008, PEDIATRICS, V121, pE441, DOI 10.1542/peds.2007-0984
   Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658
   Marcus RN, 2011, J CLIN PSYCHIAT, V72, P1270, DOI 10.4088/JCP.09m05933
   Marcus RN, 2011, J CHILD ADOL PSYCHOP, V21, P229, DOI 10.1089/cap.2009.0121
   Masi G, 2009, CNS DRUGS, V23, P511, DOI 10.2165/00023210-200923060-00005
   Matlock ST, 2011, AJIDD-AM J INTELLECT, V116, P130, DOI 10.1352/1944-7558-116.2.130
   Matson JL, 2009, RES DEV DISABIL, V30, P572, DOI 10.1016/j.ridd.2008.08.007
   Mazzone L, 2006, BRAIN DEV-JPN, V28, P668, DOI 10.1016/j.braindev.2006.05.004
   McCracken JT, 2010, J CHILD ADOL PSYCHOP, V20, P1, DOI 10.1089/cap.2009.0059
   McDougle CJ, 2002, J AM ACAD CHILD PSY, V41, P921, DOI 10.1097/00004583-200208000-00010
   Milin R, 2006, J CLIN PSYCHOPHARM, V26, P90, DOI 10.1097/01.jcp.0000196114.93376.86
   Namerow LB, 2003, J DEV BEHAV PEDIATR, V24, P104
   Niederhofer H, 2003, HUM PSYCHOPHARM CLIN, V18, P389, DOI 10.1002/hup.491
   Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
   Owley T, 2005, J AM ACAD CHILD PSY, V44, P343, DOI 10.1097/01.chi.0000153229.80215.a0
   Owley T, 2006, J CHILD ADOL PSYCHOP, V16, P517, DOI 10.1089/cap.2006.16.517
   Pearson D. A., J CHILD ADO IN PRESS
   Pearson DA, 2003, J AM ACAD CHILD PSY, V42, P209, DOI 10.1097/01.CHI.0000037009.34553.36
   Pearson DA, 2004, J AM ACAD CHILD PSY, V43, P677, DOI 10.1097/01.chi.0000124461.81324.13
   Pearson DA, 2004, J AM ACAD CHILD PSY, V43, P686, DOI 10.1097/01.chi.0000120024.14101.96
   Posey DJ, 2004, J CHILD ADOL PSYCHOP, V14, P233, DOI 10.1089/1044546041649084
   Posey DJ, 2006, J CHILD ADOL PSYCHOP, V16, P599, DOI 10.1089/cap.2006.16.599
   Posey DJ, 2007, BIOL PSYCHIAT, V61, P538, DOI 10.1016/j.biopsych.2006.09.028
   Mccracken JT, 2005, AM J PSYCHIAT, V162, P1361
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266
   Rezaei V, 2010, PROG NEURO-PSYCHOPH, V34, P1269, DOI 10.1016/j.pnpbp.2010.07.005
   Robb A. S., 2011, PRIMARY CARE COMPANI, V13
   Rugino T. A., 2002, J DEV BEHAV PEDIAT, V23
   Scahill L, 1997, J AM ACAD CHILD PSY, V36, P844, DOI 10.1097/00004583-199706000-00023
   Scahill L, 2006, J CHILD ADOL PSYCHOP, V16, P589, DOI 10.1089/cap.2006.16.589
   Shapira NA, 2004, AM J MENT RETARD, V109, P301, DOI 10.1352/0895-8017(2004)109<301:EOTIAW>2.0.CO;2
   Shapira NA, 2002, INT J NEUROPSYCHOPH, V5, P141, DOI 10.1017/S1461145702002833
   Shea S, 2004, PEDIATRICS, V114, pE634, DOI 10.1542/peds.2003-0264-F
   Shireman TI, 2005, J CHILD ADOL PSYCHOP, V15, P107, DOI 10.1089/cap.2005.15.107
   Simonoff E., 2012, J CHILD PSYCHOL PSYC
   Snyder R, 2002, J AM ACAD CHILD PSY, V41, P1026, DOI 10.1097/01.CHI.0000020270/43550.CC
   Stavrakaki C, 2004, J PSYCHIATR NEUROSCI, V29, P57
   Stigler K. A., 2012, PSYCHOPHARMACOLOGY B
   Stigler KA, 2004, J CHILD ADOL PSYCHOP, V14, P455
   Stigler KA, 2009, J CHILD ADOL PSYCHOP, V19, P265, DOI 10.1089/cap.2008.093
   Stigler KA, 2010, J CHILD ADOL PSYCHOP, V20, P75, DOI 10.1089/cap.2009.0019
   Szymanski Ludwik, 1999, Journal of the American Academy of Child and Adolescent Psychiatry, V38, p5S
   Thalayasingam S, 2004, J INTELL DISABIL RES, V48, P572, DOI 10.1111/j.1365-2788.2004.00626.x
   Troost PW, 2006, J CHILD ADOL PSYCHOP, V16, P611, DOI 10.1089/cap.2006.16.611
   Tsiouris J. A., 2012, J AUTISM DEV DISORDE
   Turgay A., 2002, PEDIATRICS, V110
   Tyrer P, 2008, LANCET, V371, P57, DOI 10.1016/S0140-6736(08)60072-0
   Valicenti-McDermott MR, 2006, J CHILD ADOL PSYCHOP, V16, P549, DOI 10.1089/cap.2006.16.549
   Zeiner P, 2011, ACTA PAEDIATR, V100, P1258, DOI 10.1111/j.1651-2227.2011.02263.x
NR 121
TC 0
Z9 0
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2211-6095
BN 978-0-12-401725-2
J9 INT REV RES DEV DISA
JI Int. Rev. Res. Dev. Disabil.
PY 2013
VL 44
BP 281
EP 325
DI 10.1016/B978-0-12-401662-0.00009-9
PG 45
WC Education, Special; Psychology, Multidisciplinary
SC Education & Educational Research; Psychology
GA BFQ02
UT WOS:000320926000010
ER

PT J
AU Cavojova, V
   Ballova Mikuskova, E
   Hanak, R
AF Cavojova, Vladimira
   Ballova Mikuskova, Eva
   Hanak, Robert
TI DO YOU HAVE TO BE SMART TO KNOW WHAT THE OTHERS ARE THINKING?
SO STUDIA PSYCHOLOGICA
LA English
DT Article
DE mindreading; general cognitive abilities; verbal abilities;
   preadolescents
ID MIND; CHILDREN; AUTISM
AB Research concerning mindreading has dealt extensively with its (in)dependence on executive functions. However, surprisingly few studies focused on direct relationship of mindreading with intelligence, although it has been proposed that high level mindreading in older children and adults is dependent on general cognitive skills. In the study reported here, two advanced mindreading tests were employed and data about participants' verbal abilities were obtained. There was no significant correlation of verbal ability and memory with any of the mindreading tasks. Our results demonstrate a lack of significant linear relationship of mindreading with the intelligence domains, language and memory as well as support the argument that mindreading exists as a specific independent cognitive domain.
C1 [Cavojova, Vladimira; Ballova Mikuskova, Eva; Hanak, Robert] Slovak Acad Sci, Inst Expt Psychol, Bratislava 81364, Slovakia.
RP Cavojova, V (reprint author), Slovak Acad Sci, Inst Expt Psychol, Dubravska Cesta 9, Bratislava 81364, Slovakia.
EM vladimira.cavojova@savba.sk
CR Apperly I, 2011, MINDREADERS: THE COGNITIVE BASIS OF THEORY OF MIND, P1
   BALLOVA MIKUSKOVA E., STUDIA PSYC IN PRESS
   Buitelaar JK, 1999, J CHILD PSYCHOL PSYC, V40, P869, DOI 10.1017/S0021963099004321
   Doherty M. J., 2009, THEORY MIND CHILDREN
   FAY E., 2001, ANAL STRUKTURY INTEL
   Heavey L, 2000, J AUTISM DEV DISORD, V30, P225, DOI 10.1023/A:1005544518785
   Humphrey N., 1976, GROWING POINTS ETHOL, P303
   Kinderman P, 1998, BRIT J PSYCHOL, V89, P191
   MENTEL A., ITEM ANAL IMPO UNPUB
   Pellicano E, 2007, DEV PSYCHOL, V43, P974, DOI 10.1037/0012-1649.43.4.974
   Perner J, 1999, TRENDS COGN SCI, V3, P337, DOI 10.1016/S1364-6613(99)01362-5
   RAJKUMAR A.P., 2008, BEHAV BRAIN FUNCT, V4, P1
   RASMUSSEN C., 2009, CANADIAN J CLIN PHAR, V16, P37
   Schneider D, 2012, PSYCHOL SCI, V23, P842, DOI 10.1177/0956797612439070
   WHITEN W., 1997, MACHIAVELLIAN INTELL
NR 15
TC 0
Z9 0
PU SLOVAK ACAD SCIENCES INST EXPERIMENTAL PSYCHOLOGY
PI BRATISLAVA
PA DUBRAVSKA CESTA 9, 813 64 BRATISLAVA, SLOVAKIA
SN 0039-3320
J9 STUD PSYCHOL
JI Studia Psychol.
PY 2013
VL 55
IS 1
BP 61
EP 66
PG 6
WC Psychology, Multidisciplinary
SC Psychology
GA 183EO
UT WOS:000321797300005
ER

PT J
AU Kaluzna-Czaplinska, J
   Zurawicz, E
   Michalska, M
   Rynkowski, J
AF Kaluzna-Czaplinska, Joanna
   Zurawicz, Ewa
   Michalska, Monika
   Rynkowski, Jacek
TI A focus on homocysteine in autism
SO ACTA BIOCHIMICA POLONICA
LA English
DT Review
DE autism; homocysteine; vitamins; nutritions; supplementation; metabolism
ID METHYLENETETRAHYDROFOLATE REDUCTASE GENE; PLASMA HOMOCYSTEINE;
   CAPILLARY-ELECTROPHORESIS; ALZHEIMERS-DISEASE; SPECTRUM DISORDER;
   OXIDATIVE STRESS; FOLIC-ACID; FOLATE; CHILDREN; METABOLISM
AB Homocysteine is an amino acid, which plays several important roles in human physiology. A wide range of disorders, including neuropsychiatric disorders and autism, are associated with increased homocysteine levels in biological fluids. Various B vitamins: B6 (pyridoxine), B12 (cobalamin), and B9 (folic acid) are required as co-factors by the enzymes involved in homocysteine metabolism. Therefore, monitoring of homocysteine levels in body fluids of autistic children can provide information on genetic and physiological diseases, improper lifestyle (including dietary habits), as well as a variety of pathological conditions. This review presents information on homocysteine metabolism, determination of homocysteine in biological fluids, and shows abnormalities in the levels of homocysteine in the body fluids of autistic children.
C1 [Kaluzna-Czaplinska, Joanna; Zurawicz, Ewa; Michalska, Monika; Rynkowski, Jacek] Tech Univ Lodz, Dept Chem, Inst Gen & Ecol Chem, PL-90924 Lodz, Poland.
RP Kaluzna-Czaplinska, J (reprint author), Tech Univ Lodz, Dept Chem, Inst Gen & Ecol Chem, PL-90924 Lodz, Poland.
EM joanna.kaluzna-czaplinska@p.lodz.pl
CR Adams JB, 2004, J ALTERN COMPLEM MED, V10, P1033
   Adams M, 2007, NEUROSCI LETT, V422, P24, DOI 10.1016/j.neulet.2007.05.025
   Ali A, 2011, ACTA BIOCHIM POL, V58, P547
   Auer J, 2001, J CLIN BASIC CARDIOL, V4, P261
   Bald E, 2000, TALANTA, V50, P1233, DOI 10.1016/S0039-9140(99)00235-0
   Bjelland I, 2003, ARCH GEN PSYCHIAT, V60, P618, DOI 10.1001/archpsyc.60.6.618
   Bogers RP, 2007, NUTRITION, V23, P97, DOI 10.1016/j.nut.2006.11.002
   Bongiovanni B, 2003, TOWNSEND LETT DOCTOR, V245, P38
   Bonig H, 2003, EUR J PEDIATR, V162, P200, DOI 10.1007/s00431-002-1148-9
   Boris M., 2004, J AM PHYS SURG, V9, P106
   Brosnan JT, 2004, ACTA BIOCHIM POL, V51, P405
   Causse E, 1999, CLIN CHEM, V45, P412
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Chwatko G, 2007, FASEB J, V21, P1707, DOI 10.1096/fj.06-7435com
   Duthie SJ, 2002, AM J CLIN NUTR, V75, P908
   ESMON CT, 1981, P NATL ACAD SCI-BIOL, V78, P2249, DOI 10.1073/pnas.78.4.2249
   Finglas PM, 2006, EUR J CLIN NUTR, V60, P287, DOI 10.1038/sj.ejcn.1602315
   Finkelstein JD, 1998, EUR J PEDIATR, V157, pS40, DOI 10.1007/PL00014300
   GERRITSEN T, 1964, PEDIATRICS, V33, P413
   Grubben MJ, 2000, AM J CLIN NUTR, V71, P480
   Guilliams TG, 2004, STANDARD, V6, P1
   Hague WM, 2003, BEST PRACT RES CL OB, V17, P459, DOI 10.1053/S1521-6934(03)00009-91
   House JD, 2000, CAN MED ASSOC J, V162, P1557
   Hustad S, 2007, AM J HUM GENET, V80, P846, DOI 10.1086/513520
   Jacobsen DW, 1998, CLIN CHEM, V44, P1833
   Jakubowski H, 2009, FASEB J, V23, P1721, DOI 10.1096/fj.08-127548
   JAKUBOWSKI H, 1990, P NATL ACAD SCI USA, V87, P4504, DOI 10.1073/pnas.87.12.4504
   Jakubowski H, 2011, ADV CLIN CHEM, V55, P81, DOI 10.1016/B978-0-12-387042-1.00005-8
   Jakubowski H, 2001, FEBS LETT, V491, P35, DOI 10.1016/S0014-5793(01)02143-3
   James SJ, 2010, AM J MED GENET B, V153B, P1209, DOI 10.1002/ajmg.b.31094
   James SJ, 2004, AM J CLIN NUTR, V80, P1611
   James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366
   Kaluzna-Czaplinska J, 2011, NUTR RES, V31, P318, DOI 10.1016/j.nutres.2011.03.009
   Kaluzna-Czaplinska J, 2009, NOWA PEDIAT, V4, P94
   Kaluzna-Czaplinska J, 2011, ACTA BIOCHIM POL, V58, P31
   Kang SS, 1992, ANNU REV NUTR, V12, P278
   Kawashima A, 2007, ASIA PAC J CLIN NUTR, V16, P411
   Kruman II, 2000, J NEUROSCI, V20, P6920
   LEE MH, 1988, BRAIN RES, V456, P104, DOI 10.1016/0006-8993(88)90351-4
   Lipton SA, 1997, P NATL ACAD SCI USA, V94, P5923, DOI 10.1073/pnas.94.11.5923
   LOWE TL, 1981, J AM ACAD CHILD PSY, V20, P104, DOI 10.1016/S0002-7138(09)60720-2
   Lutz Ulrich C, 2008, Curr Drug Abuse Rev, V1, P47
   Malinowska J, 2012, ACTA BIOCHIM POL, V59, P185
   Manolescu BN, 2010, ACTA BIOCHIM POL, V57, P467
   MCCULLY KS, 1969, AM J PATHOL, V56, P111
   MUDD SH, 1964, SCIENCE, V143, P1443, DOI 10.1126/science.143.3613.1443
   Nakata Y, 1998, AM J HYPERTENS, V11, P1019, DOI 10.1016/S0895-7061(98)00046-6
   Nekrassova O, 2003, TALANTA, V60, P1085, DOI 10.1016/S0039-9140(03)00173-5
   Nelen WLDM, 2001, CLIN CHEM LAB MED, V39, P758, DOI 10.1515/CCLM.2001.126
   Nilsson K, 2002, DEMENT GERIATR COGN, V14, P7, DOI 10.1159/000058327
   O'Callaghan P., 2002, European Heart Journal, V23, P1580, DOI 10.1053/euhj.2002.3172
   Pasca SP, 2006, LIFE SCI, V78, P2244, DOI 10.1016/j.lfs.2005.09.040
   Paul C, 2007, APPETITE, V49, P708, DOI 10.1016/j.appet.2007.07.012
   Perla-Kajan J, 2007, AMINO ACIDS, V32, P561, DOI 10.1007/s00726-006-0432-9
   Perna AF, 2005, CLIN CHEM LAB MED, V43, P1032, DOI 10.1515/CCLM.2005.181
   Pineles SL, 2010, PEDIATRICS, V126, P967
   Rafii M, 2007, ANAL BIOCHEM, V371, P71, DOI 10.1016/j.ab.2007.07.026
   Ramaekers VT, 2002, NEUROPEDIATRICS, V33, P301, DOI 10.1055/s-2002-37082
   Refsum H, 2004, CLIN CHEM, V50, P3, DOI 10.1373/clinchem.2003.021634
   Reinhardt D, 1998, EUR J CLIN INVEST, V28, P20
   Riegel B, 1935, J BIOL CHEM, V112, P149
   SAWADA S, 1982, BRAIN RES, V238, P282, DOI 10.1016/0006-8993(82)90798-3
   Sawula W, 2009, CLIN BIOCHEM, V42, P442, DOI 10.1016/j.clinbiochem.2008.12.019
   Sawula W, 2008, ACTA BIOCHIM POL, V55, P119
   Schmidt RJ, 2011, EPIDEMIOLOGY, V22, P476, DOI 10.1097/EDE.0b013e31821d0e30
   Seshadri S, 2002, NEW ENGL J MED, V346, P476, DOI 10.1056/NEJMoa011613
   Shih DM, 1962, ARCH DIS CHILD, V37, P505
   Shoveller AK, 2004, J NUTR, V134, P609
   Suh J. H., 2008, AM J BIOCH BIOTECH, V4, P105
   Thambyrajah J, 2000, CIRCULATION, V102, P871
   van der Gaag MS, 2000, LANCET, V355, P1522, DOI 10.1016/S0140-6736(00)02172-3
   Verhoef P, 2002, AM J CLIN NUTR, V76, P1244
   Waskiewicz A, 2010, KARDIOL POL, V68, P275
   Weisberg I, 1998, MOL GENET METAB, V64, P169, DOI 10.1006/mgme.1998.2714
   Williams KE, 2005, J DEV PHYS DISABIL, V17, P299, DOI 10.1007/s10882-005-4387-7
   Xia RR, 2011, J ALTERN COMPLEM MED, V17, P271, DOI 10.1089/acm.2010.0146
   Xia W, 2010, EUR J PEDIATR, V169, P1201, DOI 10.1007/s00431-010-1203-x
   Zinellu A, 2007, ANAL BIOCHEM, V363, P91, DOI 10.1016/j.ab.2007.01.009
NR 78
TC 1
Z9 1
PU ACTA BIOCHIMICA POLONICA
PI WARSAW
PA PASTEURA 3, 02-093 WARSAW, POLAND
SN 0001-527X
J9 ACTA BIOCHIM POL
JI Acta Biochim. Pol.
PY 2013
VL 60
IS 2
BP 137
EP 142
PG 6
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 176OR
UT WOS:000321314500001
PM 23741716
ER

PT J
AU Bjorklund, G
AF Bjorklund, Geir
TI The role of zinc and copper in autism spectrum disorders
SO ACTA NEUROBIOLOGIAE EXPERIMENTALIS
LA English
DT Review
DE Asperger syndrome; autism; pervasive developmental disorder;
   neurodevelopmental
ID RECEPTOR SUBUNIT GENES; ENVIRONMENTAL MERCURY RELEASE; GLUTAMIC-ACID
   DECARBOXYLASE; DOPAMINE-BETA-HYDROXYLASE; HEAVY-METALS;
   ALZHEIMERS-DISEASE; DIABETES-MELLITUS; DEFICIENCY; BRAIN; GABA
AB Autism spectrum disorders (ASDs) are a group of developmental disabilities that can cause significant social, communication and behavioral challenges. Several studies have suggested a disturbance in the copper (Cu) and zinc (Zn) metabolism in ASDs. Zinc deficiency, excess Cu levels, and low Zn/Cu ratio are common in children diagnosed with an ASD. The literature also suggests that mercury accumulation may occur as a cause or consequence of metallothionein (MT) dysfunction in children diagnosed with an ASD, which may be one of the causes of Zn deficiency. MTs are proteins with important functions in metal metabolism and protection. Zinc and Cu bind to and participate in the control of the synthesis of MT proteins. Studies indicate that the GABAergic system may be involved in ASDs, and that Zn and Cu may play a role in this system.
C1 Council Nutr & Environm Med CONEM, Mo I Rana, Norway.
RP Bjorklund, G (reprint author), Council Nutr & Environm Med CONEM, Mo I Rana, Norway.
EM bjorklund@conem.org
CR Adams JB, 2013, BIOL TRACE ELEM RES, V151, P171, DOI 10.1007/s12011-012-9551-1
   Al-Farsi YM, 2013, BIOL TRACE ELEM RES, V151, P181, DOI 10.1007/s12011-012-9553-z
   Andrews GK, 2000, BIOCHEM PHARMACOL, V59, P95, DOI 10.1016/S0006-2952(99)00301-9
   Arredondo Miguel, 2005, Molecular Aspects of Medicine, V26, P313, DOI 10.1016/j.mam.2005.07.010
   Aschner M, 1996, FASEB J, V10, P1129
   Aschner M, 2006, EXP BIOL MED, V231, P1468
   Ashley-Koch AE, 2006, ANN HUM GENET, V70, P281, DOI 10.1111/j.1469-1809.2006.00253.x
   BALES CW, 1994, J AM COLL NUTR, V13, P455
   Battaglioli G, 2005, NEUROCHEM RES, V30, P989, DOI 10.1007/s11064-005-6772-0
   BENARI Y, 1991, NATURE, V353, P220, DOI 10.1038/353220a0
   Bernard S, 2001, MED HYPOTHESES, V56, P462, DOI 10.1054/mehy.2000.1281
   Bjorklund Geir, 1998, Tidsskrift for den Norske Laegeforening, V118, P1567
   Black MM, 1998, AM J CLIN NUTR, V68, p464S
   Blanchard K. Stephen, 2011, Reviews on Environmental Health, V26, P111, DOI 10.1515/REVEH.2011.015
   Blaurock-Busch Eleonor, 2012, Maedica (Buchar), V7, P38
   Bown AW, 1997, PLANT PHYSIOL, V115, P1
   Brewer GJ, 2012, J TRACE ELEM MED BIO, V26, P89, DOI 10.1016/j.jtemb.2012.04.019
   Briefel RR, 2000, J NUTR, V130, p1367S
   Collins AL, 2006, NEUROGENETICS, V7, P167, DOI 10.1007/s10048-006-0045-1
   Craciun EC, 2009, ROM REV LAB MED S, V15, P132
   Davis G. K., 1987, TRACE ELEMENTS HUMAN, V1, P301
   Davis K, 2001, J BIOMED SCI, V8, P359, DOI 10.1007/BF02258378
   de Theije CGM, 2011, EUR J PHARMACOL, V668, pS70, DOI 10.1016/j.ejphar.2011.07.013
   Deinum J, 2004, J MED GENET, V41, DOI 10.1136/jmg.2003.009282
   DeSoto MC, 2010, ACTA NEUROBIOL EXP, V70, P165
   Dick AT, 1953, AUSTR VET J, V9, P233
   Elsheshtawy E, 2011, MIDDLE E CURR PSYCHI, V18, P6, DOI 10.1097/01.XME.0000392842.64112.64
   Faber S, 2009, BIOMARKERS, V14, P171, DOI 10.1080/13547500902783747
   FABRIS N, 1995, AGING-CLIN EXP RES, V7, P77
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   Finegold SM, 2012, ANAEROBE, V18, P260, DOI 10.1016/j.anaerobe.2011.12.018
   Geier DA, 2012, INT J ENV RES PUB HE, V9, P4486, DOI 10.3390/ijerph9124486
   Geier DA, 2010, ACTA NEUROBIOL EXP, V70, P177
   Geier DA, 2009, ACTA NEUROBIOL EXP, V69, P189
   Gould L, 2011, NUTR RES REV, V24, P176, DOI 10.1017/S0954422411000059
   Grandjean P, 2006, LANCET, V368, P2167, DOI 10.1016/S0140-6736(06)69665-7
   HALSTED JA, 1972, AM J MED, V53, P277, DOI 10.1016/0002-9343(72)90169-6
   Hambidge KM, 1986, TRACE ELEMENTS HUMAN, V2, P1
   Hambidge M, 2000, J NUTR, V130, p1344S
   HAUGAARD N, 1968, PHYSIOL REV, V48, P311
   Heyneman CA, 1996, ANN PHARMACOTHER, V30, P186
   IOM/FNB - Institute of Medicine Food and Nutrition Board, 2001, DIET REF INT VIT A V
   Kern JK, 2012, ACTA NEUROBIOL EXP, V72, P113
   Khan MWA, 2009, AUTOIMMUNITY, V42, P150, DOI 10.1080/08916930802468276
   Kim HJ, 2003, MOL PHARMACOL, V64, P1145, DOI 10.1124/mol.64.5.1145
   LAKE CR, 1977, ARCH GEN PSYCHIAT, V34, P553
   Li Q, 2008, NEUROCHEM RES, V33, P185, DOI 10.1007/s11064-007-9436-4
   Lifschitz Carlos, 2012, Acta Sci Pol Technol Aliment, V11, P183
   Lonsdale D, 2011, AUTISM RES TREAT
   Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195
   MacFabe Derrick F., 2012, Microbial Ecology in Health and Disease, V23, P19260, DOI 10.3402/mehd.v23i0.19260
   Madsen E, 2007, ANNU REV NEUROSCI, V30, P317, DOI 10.1146/annurev.neuro.30.051606.094232
   Medeiros DM, 2009, J NUTR BIOCHEM, V20, P823, DOI 10.1016/j.jnutbio.2008.08.001
   Midorikawa K, 2001, FEBS LETT, V495, P187, DOI 10.1016/S0014-5793(01)02383-3
   Midtvedt Tore, 2012, Microbial Ecology in Health and Disease, V23, P18982, DOI 10.3402/mehd.v23i0.18982
   Moxnes SF, 2008, MICROB ECOL HEALTH D, V20, P1
   Obrenovich ME, 2011, BIOL TRACE ELEM RES, V144, P475, DOI 10.1007/s12011-011-9146-2
   Oteiza Patricia I., 2005, Molecular Aspects of Medicine, V26, P245, DOI 10.1016/j.mam.2005.07.012
   Ozdemir E, 2009, PROG NEURO-PSYCHOPH, V33, P62, DOI 10.1016/j.pnpbp.2008.10.004
   Pagano G, 2012, ADV EXP MED BIOL, V724, P291, DOI 10.1007/978-1-4614-0653-2_22
   Palmer RF, 2006, HEALTH PLACE, V12, P203, DOI 10.1016/j.healthplace.2004.11.005
   Palmer RF, 2009, HEALTH PLACE, V15, P18, DOI 10.1016/j.healthplace.2008.02.001
   Park JD, 2001, TOXICOLOGY, V163, P93, DOI 10.1016/S0300-483X(01)00375-4
   Plum LM, 2010, INT J ENV RES PUB HE, V7, P1342, DOI 10.3390/ijerph7041342
   Prasad A S, 1991, Bol Asoc Med P R, V83, P558
   Prasad AS, 1997, P ASSOC AM PHYSICIAN, V109, P68
   PRASAD AS, 1983, CLIN GASTROENTEROL, V12, P713
   Prasad AS, 2012, J TRACE ELEM MED BIO, V26, P66, DOI 10.1016/j.jtemb.2012.04.004
   PRASAD AS, 1995, NUTRITION, V11, P93
   Priya MDL, 2011, BIOL TRACE ELEM RES, V142, P148, DOI 10.1007/s12011-010-8766-2
   Qian J, 2005, J PHYSIOL-LONDON, V566, P747, DOI 10.1113/jphysol.2005.089276
   Rahman K, 2009, J BIOMED SCI, V5, P395
   Reddy S, 2000, BIOCHEM J, V347, P821, DOI 10.1042/0264-6021:3470821
   Russo AF, 2008, SWISS MED WKLY, V138, P70, DOI 10.1111/j.1399-3038.2005.00348.x
   Russo A J, 2011, Biomark Insights, V6, P127, DOI 10.4137/BMI.S7286
   Salgueiro MJ, 2001, BIOL TRACE ELEM RES, V81, P215, DOI 10.1385/BTER:81:3:215
   SANDSTEAD HAROLD H., 1967, AMER J CLIN NUTR, V20, P422
   Schanen NC, 2006, HUM MOL GENET, V15, pR138, DOI 10.1093/hmg/ddl213
   Schousboe A, 2007, PROG BRAIN RES, V160, P9, DOI 10.1016/S0079-6123(06)60002-2
   Sensi SL, 2011, J NEUROSCI, V31, P16076, DOI 10.1523/JNEUROSCI.3454-11.2011
   Shankar AH, 1998, AM J CLIN NUTR, V68, p447S
   Siller SS, 2012, NEURAL PLAST, DOI 10.1155/2012/124548
   Simmer K, 1985, Acta Paediatr Scand Suppl, V319, P158
   Syme CD, 2004, J BIOL CHEM, V279, P18169, DOI 10.1074/jbc.M313572200
   Takeda A, 2006, J NEUROCHEM, V99, P670, DOI 10.1111/j.1471-4159.2006.04092.x
   Takeda A, 2006, NEUROCHEM INT, V49, P746, DOI 10.1016/j.neuint.2006.06.005
   Takeda A, 2003, J NEUROSCI RES, V72, P537, DOI 10.1002/jnr.10600
   Takeda A, 2004, J NEUROSCI RES, V75, P225, DOI 10.1002/jnr.10846
   Trigwell SM, 2001, CLIN EXP IMMUNOL, V126, P242, DOI 10.1046/j.1365-2249.2001.01653.x
   Trumbo P, 2001, J AM DIET ASSOC, V101, P294, DOI 10.1016/S0002-8223(01)00078-5
   Underwood EJ, 1977, TRACE ELEMENTS HUMAN, V4<SUP>th</SUP>
   VALLEE BL, 1993, PHYSIOL REV, V73, P79
   Van Weyenbergh J, 2004, BMC INFECT DIS, V4, DOI 10.1186/1471-2334-4-50
   Walker CF, 2004, ANNU REV NUTR, V24, P255, DOI 10.1146/annurev.nutr.23.011702.073054
   Wang Y, 2004, FASEB J, V18, P1071, DOI 10.1096/fj.03-1282com
   WAPNIR RA, 1991, BIOL TRACE ELEM RES, V29, P193
   Wei JN, 2008, NEUROCHEM RES, V33, P1459, DOI 10.1007/s11064-008-9600-5
   Wimmer U, 2005, NUCLEIC ACIDS RES, V33, P5715, DOI 10.1093/nar/gki881
   Wuehler SE, 2005, PUBLIC HEALTH NUTR, V8, P812, DOI 10.1079/PHN2005724
   Wyatt AR, 2013, CELL STRESS CHAPERON, V18, P161, DOI 10.1007/s12192-012-0365-z
   XIE XM, 1993, J PHYSIOL-LONDON, V460, P503
   Yasuda H, 2011, SCI REP-UK, V1, DOI 10.1038/srep00129
NR 102
TC 8
Z9 8
PU NENCKI INST EXPERIMENTAL BIOLOGY
PI WARSAW
PA UL PASTEURA 3, 02-093 WARSAW, POLAND
SN 0065-1400
J9 ACTA NEUROBIOL EXP
JI Acta Neurobiol. Exp.
PY 2013
VL 73
IS 2
BP 225
EP 236
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 182DB
UT WOS:000321720800002
PM 23823984
ER

PT J
AU Mullen, BR
   Khialeeva, E
   Hoffman, DB
   Ghiani, CA
   Carpenter, EM
AF Mullen, Brian R.
   Khialeeva, Elvira
   Hoffman, Daniel B.
   Ghiani, Cristina A.
   Carpenter, Ellen M.
TI Decreased reelin expression and organophosphate pesticide exposure
   alters mouse behaviour and brain morphology
SO ASN NEURO
LA English
DT Article
DE autism; cerebellum; hippocampus; olfactory bulb; reeler; social
   interaction; ultrasonic communication
ID AUTISM SPECTRUM DISORDERS; ULTRASONIC VOCALIZATIONS;
   EXTRACELLULAR-MATRIX; DEVELOPMENTAL NEUROTOXICITY; SIGNALING PATHWAY;
   DENDRITIC SPINE; MUTANT MOUSE; MICE; SCHIZOPHRENIA; METALLOPROTEINASE
AB Genetic and environmental factors are both likely to contribute to neurodevelopmental disorders, including ASDs (autism spectrum disorders). In this study, we examined the combinatorial effect of two factors thought to be involved in autism - reduction in the expression of the extracellular matrix protein reelin and prenatal exposure to an organophosphate pesticide, CPO (chlorpyrifos oxon). Mice with reduced reelin expression or prenatal exposure to CPO exhibited subtle changes in ultrasound vocalization, open field behaviour, social interaction and repetitive behaviour. Paradoxically, mice exposed to both variables often exhibited a mitigation of abnormal behaviours, rather than increased behavioural abnormalities as expected. We identified specific differences in males and females in response to both of these variables. In addition to behavioural abnormalities, we identified anatomical alterations in the olfactory bulb, piriform cortex, hippocampus and cerebellum. As with our behavioural studies, anatomical alterations appeared to be ameliorated in the presence of both variables. While these observations support an interaction between loss of reelin expression and CPO exposure, our results suggest a complexity to this interaction beyond an additive effect of individual phenotypes.
C1 [Mullen, Brian R.; Khialeeva, Elvira; Hoffman, Daniel B.; Ghiani, Cristina A.; Carpenter, Ellen M.] UCLA Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
RP Carpenter, EM (reprint author), UCLA Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
EM Ecarpenter@mednet.ucla.edu
FU Autism Speaks!; National Institute of Child Health and Human Development
   [P50-HD055784]
FX This work was supported by Autism Speaks! and pilot project funding from
   National Institute of Child Health and Human Development [grant number
   P50-HD055784 (to E.M.C.)].
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Bacchelli E, 2006, AM J MED GENET C, V142C, P13, DOI 10.1002/ajmg.c.30078
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Bennetto L, 2007, BIOL PSYCHIAT, V62, P1015, DOI 10.1016/j.biopsych.2007.04.019
   Bouchard Maryse F, 2010, Pediatrics, V125, pe1270, DOI 10.1542/peds.2009-3058
   Brigman JL, 2006, BEHAV NEUROSCI, V120, P984, DOI 10.1037/0735-7044.120.4.984
   Casanova MF, 2002, NEUROLOGY, V58, P428
   CAVINESS VS, 1982, DEV BRAIN RES, V4, P293, DOI 10.1016/0165-3806(82)90141-9
   CAVINESS VS, 1973, J COMP NEUROL, V147, P235, DOI 10.1002/cne.901470206
   Chloe A, 2006, GENE EXPR PATTERNS, V7, P730
   Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039
   D'Amelio M, 2005, MOL PSYCHIATR, V10, P1006, DOI 10.1038/sj.mp.4001714
   DARCANGELO G, 1995, NATURE, V374, P719, DOI 10.1038/374719a0
   de Rouvroit CL, 1999, EXP NEUROL, V156, P214
   Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P139, DOI 10.1023/A:1019857620251
   Fatemi SH, 2005, BIOL PSYCHIAT, V57, P777, DOI 10.1016/j.biopsych.2004.12.018
   Fischer J, 2011, GENES BRAIN BEHAV, V10, P17, DOI 10.1111/j.1601-183X.2010.00610.x
   Flaskos J, 2012, TOXICOL LETT, V209, P86, DOI 10.1016/j.toxlet.2011.11.026
   Forster E, 2006, EUR J NEUROSCI, V23, P901, DOI 10.1111/j.1460-9568.2006.04612.x
   Gould GG, 2012, PROG NEURO-PSYCHOPH, V38, P260, DOI 10.1016/j.pnpbp.2012.04.011
   Haberly LB, 2001, CHEM SENSES, V26, P551, DOI 10.1093/chemse/26.5.551
   Heisberger T, 1999, NEURON, V24, P481
   Herbert MR, 2010, CURR OPIN NEUROL, V23, P103, DOI 10.1097/WCO.0b013e328336a01f
   Hisanaga A, 2012, FEBS LETT, V586, P3349, DOI 10.1016/j.febslet.2012.07.017
   Howell BW, 1997, NATURE, V389, P733, DOI 10.1038/39607
   Jiang W, 2010, TOXICOL SCI, V115, P183, DOI 10.1093/toxsci/kfq032
   Jossin Y, 2007, J NEUROSCI, V27, P4243, DOI 10.1523/JNEUROSCI.0023-07.2007
   Keller F, 2003, MOL NEUROBIOL, V28, P1, DOI 10.1385/MN:28:1:1
   Keshvara L, 2002, J NEUROSCI, V22, P4869
   Khialeeva E, 2011, DEVELOPMENT, V138, P767, DOI 10.1242/dev.057588
   Kohno S, 2009, BIOCHEM BIOPH RES CO, V380, P93, DOI 10.1016/j.bbrc.2009.01.039
   Lane AE, 2011, J AUTISM DEV DISORD, V41, P826, DOI 10.1007/s10803-010-1103-y
   Laviola G, 2006, PSYCHOPHARMACOLOGY, V187, P331, DOI 10.1007/s00213-006-0426-z
   Liu WS, 2001, P NATL ACAD SCI USA, V98, P3477, DOI 10.1073/pnas.051614698
   MURRAY RM, 1992, J PSYCHIAT RES, V26, P225, DOI 10.1016/0022-3956(92)90029-N
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   Niu SY, 2008, J NEUROSCI, V28, P10339, DOI 10.1523/JNEUROSCI.1917-08.2008
   Pappas GD, 2001, J NEUROCYTOL, V30, P413
   Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
   Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850
   Podhorna J, 2004, BEHAV BRAIN RES, V153, P43, DOI 10.1016/j.bbr.2003.10.033
   Pramatarova A, 2008, MOL CELL NEUROSCI, V37, P178, DOI 10.1016/j.mcn.2007.09.008
   Ricceri L, 2006, TOXICOL SCI, V93, P105, DOI 10.1093/toxsci/kfl032
   Rice DS, 2001, ANNU REV NEUROSCI, V24, P1005, DOI 10.1146/annurev.neuro.24.1.1005
   Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
   Salinger WL, 2003, BEHAV NEUROSCI, V117, P1257, DOI 10.1037/0735-7044.117.6.1257
   Scattoni ML, 2009, NEUROSCI BIOBEHAV R, V33, P508, DOI 10.1016/j.neubiorev.2008.08.003
   Sigala S, 2007, NEUROSCIENCE, V144, P834, DOI 10.1016/j.neuroscience.2006.10.013
   Suzuki Y, 2003, J NEUROPSYCH CLIN N, V15, P105, DOI 10.1176/appi.neuropsych.15.1.105
   Teixeira CM, 2011, NEUROPSYCHOPHARMACOL, V36, P2395, DOI 10.1038/npp.2011.153
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   Tueting P, 1999, NEUROREPORT, V10, P1329, DOI 10.1097/00001756-199904260-00032
   van den Buuse M, 2012, PROG NEURO-PSYCHOPH, V37, P237, DOI 10.1016/j.pnpbp.2012.02.005
   Ventruti A, 2011, NEUROSCIENCE, V189, P32, DOI 10.1016/j.neuroscience.2011.05.050
   Young DM, 2010, P NATL ACAD SCI USA, V107, P11074, DOI 10.1073/pnas.1005620107
NR 56
TC 5
Z9 5
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 1759-0914
J9 ASN NEURO
JI ASN Neuro
PY 2013
VL 5
IS 1
BP 27
EP 42
AR e00106
DI 10.1042/AN20120060
PG 16
WC Neurosciences
SC Neurosciences & Neurology
GA 181YP
UT WOS:000321707200001
PM 23298182
ER

PT J
AU Aguirre, A
   Maturana, CJ
   Harcha, PA
   Saez, JC
AF Aguirre, Adam
   Maturana, Carola J.
   Harcha, Paloma A.
   Saez, Juan C.
TI Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS
   Dysfunction via Mastocytes, and Glia Activation
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID TOLL-LIKE RECEPTORS; CENTRAL-NERVOUS-SYSTEM; CORTICOTROPIN-RELEASING
   HORMONE; TUMOR-NECROSIS-FACTOR; HUMAN MAST-CELLS; GAP-JUNCTION CHANNELS;
   BLOOD-BRAIN-BARRIER; DOUBLE-STRANDED-RNA; MULTIPLE-SCLEROSIS LESIONS;
   AUTISM SPECTRUM DISORDERS
AB In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress triggers or becoming sensitized to subsequent proinflammatory challenges. The corticotropin-releasing hormone and glucocorticoids are critical players in stress-induced mastocyte degranulation and potentiation of glial inflammatory responses, respectively. Mastocytes and glial cells express different toll-like receptor (TLR) family members, and their activation via proinflammatory molecules can increase the expression of connexin hemichannels and pannexin channels in glial cells. These membrane pores are oligohexamers of the corresponding protein subunits located in the cell surface. They allow ATP release and Ca2+ influx, which are two important elements of inflammation. Consequently, activated microglia and astrocytes release ATP and glutamate, affecting myelinization, neuronal development, and survival. Binding of ligands to TLRs induces a cascade of intracellular events leading to activation of several transcription factors that regulate the expression of many genes involved in inflammation. During pregnancy, the previous responses promoted by viral infections and other proinflammatory conditions are common and might predispose the offspring to develop psychiatric disorders and neurological diseases. Such disorders could eventually be potentiated by stress and might be part of the etiopathogenesis of CNS dysfunctions including autism spectrum disorders and schizophrenia.
C1 [Aguirre, Adam; Maturana, Carola J.; Harcha, Paloma A.; Saez, Juan C.] Pontificia Univ Catolica Chile, Dept Fisiol, Santiago, Chile.
   [Aguirre, Adam; Maturana, Carola J.; Harcha, Paloma A.; Saez, Juan C.] Ctr Interdisciplinario Neurociencias Valparaiso, Inst Milenio, Valparaiso, Chile.
RP Aguirre, A (reprint author), Pontificia Univ Catolica Chile, Dept Fisiol, Alameda 340, Santiago, Chile.
EM aaguirred@uc.cl
FU FONDECYT grants FONDECYT postdoctoral fellowship [3130632]; CONICYT
   Ph.D. student fellowship [21100401, 24121474, 1111033]; Anillo [ACT-71];
   FONDEF [DO7I1086]; Chilean Science Millennium Institute [P09-022]
FX This work was partially funded by FONDECYT grants FONDECYT postdoctoral
   fellowship 3130632 (to A. Aguirre), CONICYT Ph.D. student fellowship
   21100401 (to C. J. Maturana) and 24121474 (to P. A. Harcha), and
   1111033, Anillo ACT-71, FONDEF DO7I1086, and Chilean Science Millennium
   Institute P09-022 (to J. C. Saez).
CR Abbott NJ, 2000, CELL MOL NEUROBIOL, V20, P131, DOI 10.1023/A:1007074420772
   Agresti C, 2005, BRAIN RES REV, V48, P157, DOI 10.1016/j.brainresrev.2004.12.005
   Ahn M, 2008, J NEUROSCI RES, V86, P992, DOI 10.1002/jnr.21561
   Akira S, 2006, CELL, V124, P783, DOI 10.1016/j.cell.2006.02.015
   ALBRECHT J, 1987, J NEUROCHEM, V49, P9, DOI 10.1111/j.1471-4159.1987.tb03385.x
   ALBRECHT J, 1991, NEUROSCI LETT, V127, P105, DOI 10.1016/0304-3940(91)90905-9
   Alysandratos KD, 2012, PLOS ONE, V7
   Angelidou A., 2010, J NEUROINFLAMMATION, V7
   Angelidou A, 2012, BMC PEDIATR, V12, DOI 10.1186/1471-2431-12-89
   Anisman H, 2009, J PSYCHIATR NEUROSCI, V34, P4
   Arrode-Bruses G, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-83
   Arroyo DS, 2011, INT IMMUNOPHARMACOL, V11, P1415, DOI 10.1016/j.intimp.2011.05.006
   Asadi S., 2012, J NEUROINFLAMM, P85
   Bal-Price A, 2002, GLIA, V40, P312, DOI 10.1002/glia.10124
   Baumann N, 2001, PHYSIOL REV, V81, P871
   Belliveau DJ, 2006, J BIOL CHEM, V281, P20920, DOI 10.1074/jbc.M600026200
   Bennett MVL, 2012, BRAIN RES, V1487, P3, DOI 10.1016/j.brainres.2012.08.042
   Bennett MVL, 2003, TRENDS NEUROSCI, V26, P610, DOI 10.1016/j.tins.2003.09.008
   Ben-Sasson SZ, 2011, CYTOKINE, V56, P122, DOI 10.1016/j.cyto.2011.07.006
   BERGSTEINSDOTTIR K, 1992, P NATL ACAD SCI USA, V89, P9054, DOI 10.1073/pnas.89.19.9054
   Bilbo SD, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.014.2009
   Block ML, 2007, NAT REV NEUROSCI, V8, P57, DOI 10.1038/nrn2038
   BO L, 1994, J NEUROIMMUNOL, V51, P135, DOI 10.1016/0165-5728(94)90075-2
   BRENNER T, 1994, J NEUROL SCI, V122, P210, DOI 10.1016/0022-510X(94)90300-X
   Brosnan CF, 1996, BRAIN PATHOL, V6, P243, DOI 10.1111/j.1750-3639.1996.tb00853.x
   Brown AS, 2006, SCHIZOPHRENIA BULL, V32, P200, DOI 10.1093/schbul/sbj052
   Brown Alan S, 2011, Front Psychiatry, V2, P63, DOI 10.3389/fpsyt.2011.00063
   Brown AS, 2004, ARCH GEN PSYCHIAT, V61, P774, DOI 10.1001/archpsyc.61.8.774
   Bruce CC, 2010, HORM BEHAV, V57, P56, DOI 10.1016/j.yhbeh.2009.06.004
   Bsibsi M, 2002, J NEUROPATH EXP NEUR, V61, P1013
   Bsibsi M, 2006, GLIA, V53, P688, DOI 10.1002/glia.20328
   Bsibsi M, 2012, J NEUROSCI RES, V90, P388, DOI 10.1002/jnr.22767
   Bulanova E, 2005, J IMMUNOL, V174, P3880
   Calegari F, 1999, J BIOL CHEM, V274, P22539, DOI 10.1074/jbc.274.32.22539
   Cao J, 2005, J IMMUNOL, V174, P7665
   Carpentier PA, 2005, GLIA, V49, P360, DOI 10.1002/glia.20117
   Carson MJ, 2006, IMMUNOL REV, V213, P48, DOI 10.1111/j.1600-065X.2006.00441.x
   Cashman J. R., 2008, BMC NEUROSCIENCE, V9
   Caso JR, 2007, CIRCULATION, V115, P1599, DOI 10.1161/CIRCULATIONAHA.106.603431
   Chen KQ, 2006, CELL MOL IMMUNOL, V3, P163
   CHROUSOS GP, 1995, NEW ENGL J MED, V332, P1351
   Cotrina ML, 2000, J NEUROSCI, V20, P2835
   Craven R. R., 2009, PLOS ONE, V4
   Curatolo L, 1997, CYTOKINE, V9, P734, DOI 10.1006/cyto.1997.0228
   DAHLQUIS.R, 1974, ACTA PHARMACOL TOX, V34, P368
   Davidson JO, 2012, ANN NEUROL, V71, P121, DOI 10.1002/ana.22654
   Dean JM, 2010, BRAIN BEHAV IMMUN, V24, P776, DOI 10.1016/j.bbi.2009.10.018
   DeVries HE, 1997, PHARMACOL REV, V49, P143
   DIMITRIADOU V, 1990, NEUROSCIENCE, V39, P209, DOI 10.1016/0306-4522(90)90234-U
   Dobrenis K, 2005, J NEUROSCI RES, V82, P306, DOI 10.1002/jnr.20650
   Domercq M, 2010, GLIA, V58, P730, DOI 10.1002/glia.20958
   Dostert C, 2008, SCIENCE, V320, P674, DOI 10.1126/science.1156995
   Dougherty JD, 2012, CANCER RES, V72, P4856, DOI 10.1158/0008-5472.CAN-11-2632
   Dowling P, 1996, J EXP MED, V184, P1513, DOI 10.1084/jem.184.4.1513
   Enstrom AM, 2009, CURR OPIN INVEST DR, V10, P463
   Esposito P, 2002, J PHARMACOL EXP THER, V303, P1061, DOI 10.1124/jpet.102.038497
   Eugenin EA, 2001, P NATL ACAD SCI USA, V98, P4190, DOI 10.1073/pnas.051634298
   Eugenin EA, 2012, J NEUROIMMUNE PHARM, V7, P499, DOI 10.1007/s11481-012-9352-5
   Farina C, 2007, TRENDS IMMUNOL, V28, P138, DOI 10.1016/j.it.2007.01.005
   Felts PA, 2005, BRAIN, V128, P1649, DOI 10.1093/brain/awh516
   Feuser K, 2012, CYTOKINE, V58, P178, DOI 10.1016/j.cyto.2012.01.001
   Fiala M., 2010, J NEUROINFLAMMATION, V7
   Frank MG, 2012, BRAIN BEHAV IMMUN, V26, P337, DOI 10.1016/j.bbi.2011.10.005
   Frank MG, 2011, BRAIN BEHAV IMMUN, V25, pS21, DOI 10.1016/j.bbi.2011.01.005
   Frank-Cannon T. C., 2009, MOL NEURODEGENERATIO, V4
   Frischer JM, 2009, BRAIN, V132, P1175, DOI 10.1093/brain/awp070
   Frye R. E., 2011, PEDIAT RES, V69
   Galli SJ, 2005, NAT IMMUNOL, V6, P135, DOI 10.1038/ni1158
   Garate I, 2013, BIOL PSYCHIAT, V73, P32, DOI 10.1016/j.biopsych.2012.07.005
   Garg S, 2005, J NEUROCHEM, V95, P475, DOI 10.1111/j.1471-4159.2005.03384.x
   Genain CP, 1999, NAT MED, V5, P170, DOI 10.1038/5532
   Genain CP, 1996, SCIENCE, V274, P2054, DOI 10.1126/science.274.5295.2054
   Giaume C, 1996, TRENDS NEUROSCI, V19, P319, DOI 10.1016/0166-2236(96)10046-1
   Gibb J, 2008, BRAIN BEHAV IMMUN, V22, P573, DOI 10.1016/j.bbi.2007.12.001
   Gibb J, 2011, BRAIN BEHAV IMMUN, V25, P468, DOI 10.1016/j.bbi.2010.11.008
   Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
   Glezer I, 2006, FASEB J, V20, P750, DOI 10.1096/fj.05-5234fje
   Goines P, 2010, CURR OPIN NEUROL, V23, P111, DOI 10.1097/WCO.0b013e3283373514
   Gomariz RP, 2010, CURR PHARM DESIGN, V16, P1063
   Gomez-Gonzalez B, 2010, ACTA NEUROPATHOL, V119, P303, DOI 10.1007/s00401-009-0590-4
   Gorina R, 2011, GLIA, V59, P242, DOI 10.1002/glia.21094
   Gouin JP, 2008, NEUROIMMUNOMODULAT, V15, P251, DOI 10.1159/000156468
   Goujon E, 1995, BRAIN BEHAV IMMUN, V9, P292, DOI 10.1006/brbi.1995.1028
   Graeber MB, 2010, ACTA NEUROPATHOL, V119, P89, DOI 10.1007/s00401-009-0622-0
   Graves MC, 2004, AMYOTROPH LATERAL SC, V5, P213, DOI 10.1080/14660820410020286
   Grayson BE, 2010, ENDOCRINOLOGY, V151, P1622, DOI 10.1210/en.2009-1019
   Gross O, 2011, IMMUNOL REV, V243, P136, DOI 10.1111/j.1600-065X.2011.01046.x
   Hagberg H, 2002, MENT RETARD DEV D R, V8, P30, DOI 10.1002/mrdd.10007
   Hagberg H, 2012, ANN NEUROL, V71, P444, DOI 10.1002/ana.22620
   Hanke ML, 2011, CLIN SCI, V121, P367, DOI 10.1042/CS20110164
   Harada K, 2011, J NEUROCHEM, V116, P1138, DOI 10.1111/j.1471-4159.2011.07170.x
   Hayley S, 2008, J NEUROIMMUNOL, V197, P29, DOI 10.1016/j.jneuroim.2008.03.015
   Heib V, 2007, BLOOD, V110, P946, DOI 10.1182/blood-2006-07-036889
   Heil F, 2004, SCIENCE, V303, P1526, DOI 10.1126/science.1093620
   Helmut K., 2011, PHYSIOL REV, V91, P461
   Hinkerohe D, 2011, J NEURO-ONCOL, V103, P479, DOI 10.1007/s11060-010-0456-6
   Hisahara S, 1997, J NEUROCHEM, V69, P10
   Hoftberger R, 2004, BRAIN PATHOL, V14, P43
   Hudson CA, 2008, J LEUKOCYTE BIOL, V84, P631, DOI 10.1189/jlb.1207830
   Iglesias R, 2009, J NEUROSCI, V29, P7092, DOI 10.1523/JNEUROSCI.6062-08.2009
   Iribarren P, 2005, IMMUNOL RES, V31, P165, DOI 10.1385/IR:31:3:165
   Jack CS, 2005, J IMMUNOL, V175, P4320
   Jin YX, 2009, STROKE, V40, P3107, DOI 10.1161/STROKEAHA.109.549691
   JOHNSON D, 1988, BRAIN RES, V444, P195, DOI 10.1016/0006-8993(88)90929-8
   Joseph DJ, 2011, DEV NEUROBIOL, V71, P818, DOI 10.1002/dneu.20906
   Juckel G, 2011, SCHIZOPHR RES, V131, P96, DOI 10.1016/j.schres.2011.06.018
   Junger WG, 2011, NAT REV IMMUNOL, V11, P201, DOI 10.1038/nri2938
   Jurewicz A, 2005, BRAIN, V128, P2675, DOI 10.1093/brain/awh627
   Kamasawa N, 2005, NEUROSCIENCE, V136, P65, DOI 10.1016/j.neuroscience.2005.08.027
   Kang J, 2008, J NEUROSCI, V28, P4702, DOI 10.1523/JNEUROSCI.5048-07.2008
   Kanneganti TD, 2007, IMMUNITY, V26, P433, DOI 10.1016/j.immuni.2007.03.008
   Kanneganti TD, 2010, NAT REV IMMUNOL, V10, P688, DOI 10.1038/nri2851
   Karpuk N, 2011, J NEUROSCI, V31, P414, DOI 10.1523/JNEUROSCI.5247-10.2011
   Kato Takahiro A, 2013, Front Hum Neurosci, V7, P13, DOI 10.3389/fnhum.2013.00013
   Kees T, 2012, NEURO-ONCOLOGY, V14, P64, DOI 10.1093/neuonc/nor182
   Khalil M, 2007, BRAIN RES, V1171, P18, DOI 10.1016/j.brainres.2007.07.034
   Kigerl KA, 2007, J NEUROCHEM, V102, P37, DOI 10.1111/j.1471-4159.2007.04524.x
   Kilic U, 2008, NEUROBIOL DIS, V31, P33, DOI 10.1016/j.nbd.2008.03.002
   Kim H, 2008, IMMUNOLOGY, V124, P480, DOI 10.1111/j.1365-2567.2007.02799.x
   Kim S, 2011, J NEUROCHEM, V116, P53, DOI 10.1111/j.1471-4159.2010.07084.x
   Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004
   Krasowska-Zoladek A, 2007, J NEUROSCI RES, V85, P205, DOI 10.1002/jnr.21088
   Kubo Y, 2007, INFLAMM RES, V56, P70, DOI 10.1007/s00011-006-6064-4
   Kulka M, 2004, J ALLERGY CLIN IMMUN, V114, P174, DOI 10.1016/j.jaci.2004.03.049
   Kulka M, 2006, Mol Immunol, V43, P1579, DOI 10.1016/j.molimm.2005.09.019
   Kvetnoi I. M., 2003, Arkhiv Patologii, V65, P36
   LEALBERUMEN I, 1994, J IMMUNOL, V152, P5468
   Lehnardt S, 2002, J NEUROSCI, V22, P2478
   Lehnardt S, 2003, P NATL ACAD SCI USA, V100, P8514, DOI 10.1073/pnas.1432609100
   Li JR, 2008, J NEUROSCI, V28, P5321, DOI 10.1523/JNEUROSCI.3995-07.2008
   LININGTON C, 1988, AM J PATHOL, V130, P443
   Liu T., 2012, NEUROSCI BULL, P1
   Locovei S, 2006, FEBS LETT, V580, P239, DOI 10.1016/j.febslet.2005.12.004
   Lozada A, 2005, NEUROPATH APPL NEURO, V31, P150, DOI 10.1111/j.1365-2990.2004.00622.x
   Magnotti LM, 2011, GLIA, V59, P1064, DOI 10.1002/glia.21179
   Malamud V, 2003, J NEUROIMMUNOL, V138, P115, DOI 10.1016/S0165-5728(03)00090-0
   Mallard C, 2009, CLIN PERINATOL, V36, P763, DOI 10.1016/j.clp.2009.07.009
   MANNING KA, 1994, NEUROSCIENCE, V63, P191, DOI 10.1016/0306-4522(94)90016-7
   Mariathasan S, 2006, NATURE, V440, P228, DOI 10.1038/nature04515
   Marshall JS, 2004, NAT REV IMMUNOL, V4, P787, DOI 10.1038/nri1460
   Marta M, 2009, ANN NY ACAD SCI, V1173, P458, DOI 10.1111/j.1749-6632.2009.04849.x
   Martinez AD, 2002, CIRC RES, V90, P1100, DOI 10.1161/01.RES.0000019580.64013.31
   Masuda A, 2002, J IMMUNOL, V169, P3801
   Matsushima H, 2004, J IMMUNOL, V173, P531
   McCloskey MA, 1999, J IMMUNOL, V163, P970
   McCurdy JD, 2003, J IMMUNOL, V170, P1625
   McCurdy JD, 2001, J LEUKOCYTE BIOL, V70, P977
   Merrill JE, 1999, NEUROPATH APPL NEURO, V25, P435
   Meyer U, 2012, NEUROPHARMACOLOGY, V62, P1308, DOI 10.1016/j.neuropharm.2011.01.009
   Meyer U, 2006, J NEUROSCI, V26, P4752, DOI 10.1523/JNEUROSCI.0099-06.2006
   Michaloudi H, 2007, J ANAT, V211, P556, DOI 10.1111/j.1469-7580.2007.00795.x
   Mirescu C, 2004, NAT NEUROSCI, V7, P841, DOI 10.1038/nn1290
   Miron VE, 2011, BBA-MOL BASIS DIS, V1812, P184, DOI 10.1016/j.bbadis.2010.09.010
   MOKHTARIAN F, 1984, CELL IMMUNOL, V86, P491, DOI 10.1016/0008-8749(84)90404-0
   Molino M, 1997, J BIOL CHEM, V272, P4043
   Mrabet-Dahbi S, 2009, EXP DERMATOL, V18, P437, DOI 10.1111/j.1600-0625.2009.00878.x
   Nagy JI, 2003, GLIA, V44, P205, DOI 10.1002/glia.10278
   Nakata Akinori, 2012, Methods Mol Biol, V934, P39, DOI 10.1007/978-1-62703-071-7_3
   Napoli I, 2009, NEUROSCIENCE, V158, P1030, DOI 10.1016/j.neuroscience.2008.06.046
   Nigo YI, 2006, P NATL ACAD SCI USA, V103, P2286, DOI 10.1073/pnas.0510685103
   Nualart-Marti A, 2013, BBA-BIOMEMBRANES, V1828, P69, DOI 10.1016/j.bbamem.2012.01.024
   Okun E, 2009, BRAIN RES REV, V59, P278, DOI 10.1016/j.brainresrev.2008.09.001
   Olejar T, 2002, INT J TISSUE REACT, V24, P81
   Orellana JA, 2011, J NEUROSCI, V31, P4962, DOI 10.1523/JNEUROSCI.6417-10.2011
   Orellana JA, 2010, GLIA, V58, P329, DOI 10.1002/glia.20926
   Orellana JA, 2011, J NEUROCHEM, V118, P826, DOI 10.1111/j.1471-4159.2011.07210.x
   Orellana JA, 2009, ANTIOXID REDOX SIGN, V11, P369, DOI 10.1089/ars.2008.2130
   Orinska Z, 2005, BLOOD, V106, P978, DOI 10.1182/blood-2004-07-2656
   Ossovskaya VS, 2004, PHYSIOL REV, V84, P579, DOI 10.1152/physrev.00028.2003
   Pace TWW, 2009, ANN NY ACAD SCI, V1179, P86, DOI 10.1111/j.1749-6632.2009.04984.x
   Palmieri L, 2010, BBA-BIOENERGETICS, V1797, P1130, DOI 10.1016/j.bbabio.2010.04.018
   Pang Y, 2003, DEV BRAIN RES, V140, P205, DOI 10.1016/S0165-3806(02)00606-5
   Parekh AB, 2005, PHYSIOL REV, V85, P757, DOI 10.1152/physrev.00057.2003
   Parenti R, 2002, ARCH ITAL BIOL, V140, P101
   PARPURA V, 1994, NATURE, V369, P744, DOI 10.1038/369744a0
   Parpura V, 2004, NEUROCHEM INT, V45, P259, DOI 10.1016/j.neuint.2003.12.011
   Patel J, 2012, INT J MOL SCI, V13, P10647, DOI 10.3390/ijms130810647
   Pelegrin P, 2006, EMBO J, V25, P5071, DOI 10.1038/sj.emboj.7601378
   Petrilli V, 2007, CELL DEATH DIFFER, V14, P1583, DOI 10.1038/sj.cdd.4402195
   Polazzi E, 2006, J NEUROIMMUNOL, V172, P104, DOI 10.1016/j.jneuroim.2005.11.005
   Ponomarev EA, 2006, J IMMUNOL, V176, P1402
   Ponomarev ED, 2005, J NEUROSCI RES, V81, P374, DOI 10.1002/jnr.20488
   Pouly S, 2000, J NEUROPATH EXP NEUR, V59, P280
   Queiroz G, 1997, NEUROSCIENCE, V78, P1203, DOI 10.1016/S0306-4522(96)00637-9
   Redwine JM, 2001, AM J PATHOL, V159, P1219, DOI 10.1016/S0002-9440(10)62507-2
   Retamal MA, 2007, J NEUROSCI, V27, P13781, DOI 10.1523/JNEUROSCI.2042-07.2007
   Ribes S, 2010, NEUROSCI LETT, V482, P17, DOI 10.1016/j.neulet.2010.06.078
   Rivest S, 2009, NAT REV IMMUNOL, V9, P429, DOI 10.1038/nri2565
   Rohatgi T, 2004, J NEUROSCI RES, V75, P273, DOI 10.1002/jnr.10847
   Rovegno M, 2012, MED INTENSIVA, V36, P37, DOI 10.1016/j.medin.2011.06.008
   ROZNIECKI JJ, 1995, ANN NEUROL, V37, P63, DOI 10.1002/ana.410370112
   Saez JC, 2005, BBA-BIOMEMBRANES, V1711, P215, DOI 10.1016/j.bbamem.2005.01.014
   Saez JC, 2010, EXP CELL RES, V316, P2377, DOI 10.1016/j.yexcr.2010.05.026
   Sanders P, 2007, BRAIN RES REV, V54, P274, DOI 10.1016/j.brainresrev.2007.03.001
   Sayed BA, 2011, J IMMUNOL, V186, P3294, DOI 10.4049/jimmunol.1003574
   Scemes E, 2006, GLIA, V54, P716, DOI 10.1002/glia.20374
   Schenk U, 2008, SCI SIGNAL, V1, DOI 10.1126/scisignal.1160583
   Schonberg DL, 2007, J NEUROPATH EXP NEUR, V66, P1124, DOI 10.1097/nen.0b013e31815c2530
   SCHOUSBOE A, 1993, DEV NEUROSCI-BASEL, V15, P359, DOI 10.1159/000111356
   Scumpia PO, 2005, GLIA, V52, P153, DOI 10.1002/glia.20234
   Secor VH, 2000, J EXP MED, V191, P813, DOI 10.1084/jem.191.5.813
   SELMAJ KW, 1988, ANN NEUROL, V23, P339, DOI 10.1002/ana.410230405
   Setzu A, 2006, GLIA, V54, P297, DOI 10.1002/glia.20371
   Sharma R, 2010, ACTA NEUROPATHOL, V120, P223, DOI 10.1007/s00401-010-0704-z
   Shi LM, 2009, BRAIN BEHAV IMMUN, V23, P116, DOI 10.1016/j.bbi.2008.07.012
   Silverman WR, 2009, J BIOL CHEM, V284, P18143, DOI 10.1074/jbc.M109.004804
   Simard M, 1999, GLIA, V28, P1, DOI 10.1002/(SICI)1098-1136(199910)28:1<1::AID-GLIA1>3.0.CO;2-4
   Skaper SD, 2012, FASEB J, V26, P3103, DOI 10.1096/fj.11-197194
   Steelman A. J., 2011, J NEUROINFLAMMATION, V8
   Stehberg J, 2012, FASEB J, V26, P3649, DOI 10.1096/fj.11-198416
   Sternberg EM, 2006, NAT REV IMMUNOL, V6, P318, DOI 10.1038/nri1810
   Stout C, 2003, GLIA, V43, P265, DOI 10.1002/glia.10257
   Strbian D, 2006, J CEREBR BLOOD F MET, V26, P605, DOI 10.1038/sj.jcbfm.9600228
   Strbian D, 2007, J CEREBR BLOOD F MET, V27, P795, DOI 10.1038/sj.jcbfm.9600387
   Sugama S, 2009, MED HYPOTHESES, V73, P1031, DOI 10.1016/j.mehy.2009.02.047
   Sugama S, 2009, J NEUROIMMUNOL, V207, P24, DOI 10.1016/j.jneuroim.2008.11.007
   Supajatura V, 2002, J CLIN INVEST, V109, P1351, DOI 10.1172/JCI200214704
   Supajatura V, 2001, J IMMUNOL, V167, P2250
   Sutterwala FS, 2006, IMMUNITY, V24, P317, DOI 10.1016/j.immuni.2006.02.004
   Suzuki R, 1999, J IMMUNOL, V163, P2410
   Tang SC, 2007, P NATL ACAD SCI USA, V104, P13798, DOI 10.1073/pnas.0702553104
   Tang SC, 2008, EXP NEUROL, V213, P114, DOI 10.1016/j.expneurol.2008.05.014
   TATHAM PER, 1990, J GEN PHYSIOL, V95, P459, DOI 10.1085/jgp.95.3.459
   Theoharides TC, 2009, EXPERT OPIN PHARMACO, V10, P2127, DOI 10.1517/14656560903107789
   Theoharides TC, 1998, ENDOCRINOLOGY, V139, P403, DOI 10.1210/en.139.1.403
   THEOHARIDES TC, 1995, ENDOCRINOLOGY, V136, P5745, DOI 10.1210/en.136.12.5745
   THEOHARIDES TC, 1990, LIFE SCI, V46, P607, DOI 10.1016/0024-3205(90)90129-F
   Theoharides TC, 2007, FRONT BIOSCI, V12, P1615, DOI 10.2741/2174
   Theoharides TC, 2005, BRAIN RES REV, V49, P65, DOI 10.1016/j.brainresrev.2004.11.006
   Theoharides TC, 2011, J CLIN PSYCHOPHARM, V31, P685, DOI 10.1097/JCP.0b013e318239c190
   Theoharides TC, 2004, TRENDS PHARMACOL SCI, V25, P563, DOI 10.1016/j.tips.2004.09.007
   Thornton P, 2006, J NEUROCHEM, V98, P258, DOI 10.1111/j.1471-4159.2006.03872.x
   Tokunaga A, 2010, J BIOL CHEM, V285, P17406, DOI 10.1074/jbc.M110.112417
   Town T, 2006, J IMMUNOL, V176, P3804
   Tuncel N, 2005, PEPTIDES, V26, P827, DOI 10.1016/j.peptides.2004.12.019
   TUOMISTO L, 1983, AGENTS ACTIONS, V13, P255, DOI 10.1007/BF01967346
   Turrin NP, 2006, MOL NEUROBIOL, V34, P221, DOI 10.1385/MN:34:3:221
   Varadaradjalou S, 2003, EUR J IMMUNOL, V33, P899, DOI 10.1002/eji.200323830
   VARTANIAN T, 1995, MOL MED, V1, P732
   Vasiadi M, 2012, J ALLERGY CLIN IMMUN, V129, P1410, DOI 10.1016/j.jaci.2012.01.041
   Venero JL, 2011, CELL DEATH DIFFER, V18, P1679, DOI 10.1038/cdd.2011.107
   Vliagoftis H, 1999, J ALLERGY CLIN IMMUN, V103, P656, DOI 10.1016/S0091-6749(99)70239-3
   von zur Mühlen F, 1991, Proc Natl Acad Sci U S A, V88, P926
   Wang T, 2004, NAT MED, V10, P1366, DOI 10.1038/nm1140
   Wierzbicki M, 2009, MICROBIOL IMMUNOL, V53, P694, DOI 10.1111/j.1348-0421.2009.00174.x
   Wills S, 2009, BRAIN BEHAV IMMUN, V23, P64, DOI 10.1016/j.bbi.2008.07.007
   Yarovinsky F, 2005, SCIENCE, V308, P1626, DOI 10.1126/science.1109893
   Yoshioka M, 2007, J ALLERGY CLIN IMMUN, V120, P452, DOI 10.1016/j.jaci.2007.03.027
   Zhang B., 2010, J NEUROINFLAMMATION, V7
   Zhang BD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049767
   Zhang BD, 2011, J ALLERGY CLIN IMMUN, V127, P1522, DOI 10.1016/j.jaci.2011.02.005
   Zhang Q, 2010, NATURE, V464, P104, DOI 10.1038/nature08780
   Zhu FG, 2001, J LEUKOCYTE BIOL, V69, P253
NR 253
TC 5
Z9 5
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
AR 893521
DI 10.1155/2013/893521
PG 17
WC Cell Biology; Immunology
SC Cell Biology; Immunology
GA 183ZC
UT WOS:000321854900001
ER

PT J
AU Cassella, A
AF Cassella, Antonio
TI A Heuristic View of the Neurobiological Correlates of Classical and
   Quantum Neural Computing From the Perspective of Autistic Syndrome
   Disorders
SO NEUROQUANTOLOGY
LA English
DT Article
DE heuristic view; neurobiological correlates; quantum neural computing;
   autism
ID CEREBELLUM; MIND
AB Anomalies in the discourse of autistic individuals and in their performance in ambiguous situations suggest that quantum neural computing, or the second attention, is impaired in autism. When nonautistic individuals face a dilemma, quantum divergence-coherence a) suspends the legitimacy of relevant prototypical knowledge conserved through classical neural computing, or the first attention; b) launches the implicit self into opposite directions; and c) simulates the consequences of clashing variants in the working memory fed by cerebellar microcomplexes. Conversely, quantum convergence-decoherence selects a useful or amusing variant to reduce the consequences of blind trial-and-error in readjusting the knowledge stored in the long-term memory banks of the cerebral cortex. In this article, a view of the psychological roots of quantum coherence-decoherence, injuries detected in autopsied brains of infants and adults with autism, and the application of modern control theory to cerebellar-brainstem microcomplexes lead to a preliminary heuristics on the complementarity of classical and quantum computing in the nonautistic brain.
C1 Merida State Inst Res Social Intelligence & Autis, Inst Merideno Invest Inteligencia Social & Autism, Estado Merida, Venezuela.
RP Cassella, A (reprint author), Merida State Inst Res Social Intelligence & Autis, Inst Merideno Invest Inteligencia Social & Autism, 349 Zea, Estado Merida, Venezuela.
EM acassella1@gmail.com
CR ALBUS J S, 1971, Mathematical Biosciences, V10, P25, DOI 10.1016/0025-5564(71)90051-4
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Baron-Cohen S, 1995, MINDBLINDNESS
   Bauman ML, 2006, NEUROBIOLOGY AUTISM, P121
   Bostan AC, 2010, P NATL ACAD SCI USA, V107, P8452, DOI 10.1073/pnas.1000496107
   Cassella A, 2002, DESARROLLO INTELIGEN
   Cassella A, 2013, COMPREHENSI IN PRESS
   Cassella A, 1997, THESIS HARVARD U
   Cassella A, 2000, THESIS UNESR CARACAS
   Cassella A, 2008, HUMAN ECOLOGY EC FRA, P230
   Cassella A, 2011, NEUROQUANTOLOGY, V9, P271
   Cassella A, 2013, COMPREHENSI IN PRESS
   Feynman R P, 1985, STRANGE THEORY LIGHT
   HAPPE FGE, 1994, J CHILD PSYCHOL PSYC, V35, P215, DOI 10.1111/j.1469-7610.1994.tb01159.x
   Icke Vincent, 1995, FORCE SYMMETRY
   Ito M, 2008, NAT REV NEUROSCI, V9, P304, DOI 10.1038/nrn2332
   ITO M, 1982, J PHYSIOL-LONDON, V324, P113
   Ito M, 2011, REV NEUROL
   Johnson Mark H., 1995, P735
   Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P115
   Leslie A. M., 1993, UNDERSTANDING OTHER, P83
   Lloyd Seth, 2006, PROGRAMMING UNIVERSE
   Perner Josef, 1991, UNDERSTANDING REPRES
   Rodier PM, 2006, NEUROBIOLOGY AUTISM, P136
   Sears LL, 1999, PROG NEURO PSYCHO PS, V23, P713
   SEARS LL, 1994, J AUTISM DEV DISORD, V24, P737, DOI 10.1007/BF02172283
   Stanton ME, 2001, NEUROTOXICOL TERATOL, P23
   ZAITCHIK D, 1990, COGNITION, V35, P41, DOI 10.1016/0010-0277(90)90036-J
NR 28
TC 0
Z9 0
PU ANKA PUBLISHER
PI BORNOVA
PA 116-11 SOK NO.10 K 2 D 2, BORNOVA, IZMIR 35050, TURKEY
SN 1303-5150
J9 NEUROQUANTOLOGY
JI NeuroQuantology
PY 2013
VL 11
IS 2
BP 314
EP 331
PG 18
WC Neurosciences
SC Neurosciences & Neurology
GA 172WS
UT WOS:000321037500014
ER

PT J
AU Thompson, RM
   Johnston, S
AF Thompson, Robyn M.
   Johnston, Susan
TI Use of Social Stories to Improve Self-Regulation in Children with Autism
   Spectrum Disorders
SO PHYSICAL & OCCUPATIONAL THERAPY IN PEDIATRICS
LA English
DT Article
DE Autism spectrum disorders; functional behaviors; school-based practice;
   self-regulation; Social Stories
ID OCCUPATIONAL-THERAPY; SENSORY INTEGRATION; SINGLE-SUBJECT; DIAGNOSIS;
   OUTCOMES
AB A multiple baseline across participants design was used to evaluate the effects of Social Stories to help preschool-aged children with characteristics of Autism Spectrum Disorders (ASD) increase their engagement in functional behaviors and use sensory integrative-based strategies to promote self-regulation. Three children, 3-5 years old, from a self-contained preschool classroom were selected to participate in the study. The intervention package included reading individualized Social Stories that discussed desired behaviors and self-regulation strategies. The researchers measured the percentage of intervals in which participants engaged in desired behaviors. The frequency of desired behaviors increased for all participants. The use of self-regulation strategies varied across participants. These findings suggest that the intervention was successful in increasing desired behaviors of the three children. Further research is recommended on the effectiveness of embedding sensory integrative strategies into Social Stories. Practitioners may consider the use of Social Stories as a tool to increase independence and encourage self-regulated behaviors in children with characteristics of ASD.
C1 [Thompson, Robyn M.; Johnston, Susan] Univ Utah, Dept Special Educ, Coll Educ, Salt Lake City, UT 84112 USA.
RP Thompson, RM (reprint author), Univ Utah, Dept Special Educ, 1705 E Campus Ctr Dr,Rm 221, Salt Lake City, UT 84112 USA.
EM robyn.m.thompson@utah.edu
CR Agotsa E., 2004, INTERV SCH CLIN, V39, P276
   A.P.A, 2000, DIAGN STAT MAN TEXT
   Ayres AJ, 1979, SENSORY INTEGRATION
   Barry L. M., 2004, FOCUS AUTISM OTHER D, V19, P45, DOI DOI 10.1177/10883576040190010601
   Case-Smith J, 1999, AM J OCCUP THER, V53, P489
   Cohn E, 2000, AM J OCCUP THER, V54, P36, DOI 10.5014/ajot.54.1.36
   Crozier S, 2007, J AUTISM DEV DISORD, V37, P1803, DOI 10.1007/s10803-006-0315-7
   Dunn W., 2006, SENSORY PROFILE SCH
   Gray C. A., 1993, FOCUS AUTISTIC BEHAV, V8, P1, DOI DOI 10.1177/108835769300800101
   Gray C. A, 2004, JENISON AUTISM J, V15, P2
   Hagiwara T., 1999, FOCUS AUTISM OTHER D, V19, P164
   Ivey M. L., 2004, FOCUS AUTISM OTHER D, V19, P164, DOI DOI 10.1177/10883576040190030401
   Johnston S., 2011, SINGLE CASE RES DESI, P99
   Johnston S., 2005, J SPECIAL ED TECHNOL, V2, P45
   Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
   Kuoch H., 2003, FOCUS AUTISM OTHER D, V18, P219, DOI DOI 10.1177/10883576030180040301
   Lane SL, 2002, SENSORY INTEGRATION, P101
   Linderman TM, 1999, AM J OCCUP THER, V53, P207
   Marr D., 2007, PHYS OCCUPATIONAL TH, V27, P64
   McDonnell J. J., 2011, SINGLE CASE RES DESI, P15
   Miller L. J., 2006, SENSATIONAL KIDS HOP
   Miller LJ, 2007, AM J OCCUP THER, V61, P135
   Noonan M. J., 2003, CHILDREN COMMUNICATI, P409
   NOURBAKHSH MR, 1994, PHYS THER, V74, P768
   O'Neill R. E., 1997, FUNCTIONAL ASSESSMEN, V2nd
   O'Neill R. E., 2011, SINGLE CASE RES DESI, P1
   O'Neill R. E., 2011, SINGLE CASE RES DESI, P39
   Ottenbacher KJ, 1986, EVALUATING CLIN CHAN
   Parham D. L., 2005, OCCUPATIONAL THERAPY, P356
   Rogers SL, 2005, OCCUPATIONAL THERAPY, P160
   Scattone D, 2002, J AUTISM DEV DISORD, V32, P535, DOI 10.1023/A:1021250813367
   Schaaf R. C., 2010, FRAMES REFERENCE PED, P99
   Schaaf RC, 2007, AM J OCCUP THER, V61, P239
   Simpson RL, 2003, TOP LANG DISORD, V23, P116
   Swaggart B. L., 1995, FOCUS AUTISTIC BEHAV, V10, P1
   White O., 2011, SINGLE CASE RES DESI, P49
NR 36
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0194-2638
J9 PHYS OCCUP THER PEDI
JI Phys. Occup. Ther. Pediatr.
PY 2013
VL 33
IS 3
BP 271
EP 284
DI 10.3109/01942638.2013.768322
PG 14
WC Pediatrics; Rehabilitation
SC Pediatrics; Rehabilitation
GA 178GA
UT WOS:000321432000002
PM 23437903
ER

PT J
AU Kramer, JM
AF Kramer, Jessica M.
TI A New Approach to the Measurement of Adaptive Behavior: Development of
   the PEDI-CAT for Children and Youth with Autism Spectrum Disorders (vol
   32, pg 34, 2012)
SO PHYSICAL & OCCUPATIONAL THERAPY IN PEDIATRICS
LA English
DT Correction
CR Kramer JM, 2012, PHYS OCCUP THER PEDI, V32, P34, DOI 10.3109/01942638.2011.606260
NR 1
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0194-2638
J9 PHYS OCCUP THER PEDI
JI Phys. Occup. Ther. Pediatr.
PY 2013
VL 33
IS 3
BP 366
EP 367
DI 10.3109/01942638.2013.785185
PG 2
WC Pediatrics; Rehabilitation
SC Pediatrics; Rehabilitation
GA 178GA
UT WOS:000321432000009
ER

PT J
AU Kuvacheva, NV
   Salmina, AB
   Komleva, YK
   Malinovskaya, NA
   Morgun, AV
   Pozhilenkova, EA
   Zamai, GS
   Yauzina, NA
   Petrova, MM
AF Kuvacheva, N. V.
   Salmina, A. B.
   Komleva, Yu. K.
   Malinovskaya, N. A.
   Morgun, A. V.
   Pozhilenkova, E. A.
   Zamai, G. S.
   Yauzina, N. A.
   Petrova, M. M.
TI Permeability of the hematoencephalic barrier in normalcy, brain
   development pathology and neurodegeneration
SO ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA
LA Russian
DT Review
DE hematoencephalic barrier; brain development pathology; neurodegeneration
ID ASTROCYTE-ENDOTHELIAL INTERACTIONS; CENTRAL-NERVOUS-SYSTEM; CELLS;
   DISEASE; INFLAMMATION; AUTISM; TRANSPORT
C1 [Kuvacheva, N. V.] Voyno Yasenetskiy Krasnoyarsk State Med Univ, Krasnoyarsk, Russia.
   Minist Hlth Russian Federat, Moscow, Russia.
RP Kuvacheva, NV (reprint author), Voyno Yasenetskiy Krasnoyarsk State Med Univ, Krasnoyarsk, Russia.
EM natalyalcuvacheva@gmail.com
RI Salmina, Alla/L-7977-2013; Malinovskaya, Nataliya/N-7602-2013; Petrova,
   Marina/L-5623-2014; Komleva, Yulia/F-3529-2014
OI Malinovskaya, Nataliya/0000-0002-0033-3804; Petrova,
   Marina/0000-0002-8493-0058; 
CR Abbott NJ, 2002, J ANAT, V200, P629, DOI 10.1046/j.1469-7580.2002.00064.x
   Abbott NJ, 2006, NAT REV NEUROSCI, V7, P41, DOI 10.1038/nrn1824
   Abbott NJ, 2010, NEUROBIOL DIS, V37, P13, DOI 10.1016/j.nbd.2009.07.030
   Angelidou A, 2012, BMC PEDIATR, V12, DOI 10.1186/1471-2431-12-89
   Ballabh P, 2004, NEUROBIOL DIS, V16, P1, DOI 10.1016/j.nbd.2003.12.016
   Begley DJ, 2004, PHARMACOL THERAPEUT, V104, P29, DOI 10.1016/j.pharmthera.2004.08.001
   BELOPASOV VV, 2001, SB MATH, V2, P223
   Biron K. E., 2011, PLOS ONE, V6, P23789
   Blau C. W., 2012, NEUROBIOL AGING, V33, p[23, 1005]
   BRADBURY MWB, 1985, CIRC RES, V57, P213
   Carvey PM, 2005, EUR J NEUROSCI, V22, P1158, DOI 10.1111/j.1460-9568.2005.04281.x
   Chalbot S, 2010, NEUROSCI LETT, V478, P179, DOI 10.1016/j.neulet.2010.05.012
   del Zoppo G J, 2000, Thromb Res, V98, P73, DOI 10.1016/S0049-3848(00)00218-8
   del Valle J, 2009, INT J DEV NEUROSCI, V27, P47, DOI 10.1016/j.ijdevneu.2008.10.002
   Desai BS, 2007, CELL TRANSPLANT, V16, P285
   DeVries HE, 1997, PHARMACOL REV, V49, P143
   Donahue JE, 2008, J NEUROPATH EXP NEUR, V67, P261, DOI 10.1097/NEN.0b013e31816a0dc8
   Dore-Duffy P, 2008, CURR PHARM DESIGN, V14, P1581
   Gumbleton M, 2001, J PHARM SCI-US, V90, P1681, DOI 10.1002/jps.1119
   HAFLER DA, 1987, IMMUNOL REV, V100, P307, DOI 10.1111/j.1600-065X.1987.tb00537.x
   Hawkins BT, 2005, PHARMACOL REV, V57, P173, DOI 10.1124/pr.57.2.4
   JANZER RC, 1987, NATURE, V325, P253, DOI 10.1038/325253a0
   LASSMANN H, 1991, REV NEUROL, V147, P763
   Li XH, 2012, BRAIN RES BULL, V88, P543, DOI 10.1016/j.brainresbull.2012.05.017
   Onore C. E., 2012, BIOL PSYCHIST, DOI [10.1016/j.bio-psych.2012.05.004, DOI 10.1016/J.BI0-PSYCH.2012.05.004]
   Peca J., 2012, CURR OPIN NEUROBIOL, DOI DOI 10.1016/J.C0NB.2012.02.015
   Peppiatt CM, 2006, NATURE, V443, P700, DOI 10.1038/nature05193
   Persidsky Y, 1997, J IMMUNOL, V158, P3499
   RAPOPORT SI, 1979, BRAIN RES, V172, P354, DOI 10.1016/0006-8993(79)90546-8
   Salmina AB, 2010, J ALZHEIMERS DIS, V22, P17, DOI 10.3233/JAD-2010-091690
   Saunders N. R., 2012, FRONTIERS PHARM, V3, DOI 10/3389/fphar.2012.00046
   Shalev H., 2009, CARDIOVASCULAR PSYCH, P1
   Starr JM, 2009, PSYCHIAT RES-NEUROIM, V171, P232, DOI 10.1016/j.pscychresns.2008.04.003
   STEWART PA, 1981, DEV BIOL, V84, P183, DOI 10.1016/0012-1606(81)90382-1
   Stolp H. B., 2011, CARDIOVASC PSYCHIAT, V10, DOI [10.1155/2011/469046, DOI 10.1155/2011/469046]
   TARANUSHENKO TE, 2010, PEDIATRICS, V89, P25
   Theoharides TC, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-168
   TONTSCH U, 1991, BRAIN RES, V539, P247, DOI 10.1016/0006-8993(91)91628-E
   VANBREE JBMM, 1988, J PHARMACOL EXP THER, V247, P1233
   Vandamme W, 2004, J NEUROCHEM, V88, P411, DOI 10.1046/j.1471-4159.2003.02163.x
   VanGilder RL, 2011, PHARMACOL THERAPEUT, V130, P239, DOI 10.1016/j.pharmthera.2010.12.004
   WEKERLE H, 1986, EUR J IMMUNOL, V16, P1551, DOI 10.1002/eji.1830161214
   YAKHNO NN, 2001, ZH NEVROPATOL PSIKH, V5, P39
   Yang Y, 2011, STROKE, V42, P3323, DOI 10.1161/STROKEAHA.110.608257
   Zonta M, 2003, NAT NEUROSCI, V6, P43, DOI 10.1038/nn980
NR 45
TC 0
Z9 0
PU IZDATELSTVO MEDITSINA
PI MOSCOW
PA PETROVERIGSKII PER 6-8, K-142 MOSCOW, RUSSIA
SN 1997-7298
J9 ZH NEVROL PSIKHIATR
JI Z. Nevrol. Psikhiatrii Im S S Korsakova
PY 2013
VL 113
IS 4
BP 80
EP 85
PG 6
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 167LW
UT WOS:000320634500016
PM 23814823
ER

PT J
AU Hunsberger, JG
   Fessler, EB
   Chibane, FL
   Leng, Y
   Maric, D
   Elkahloun, AG
   Chuang, DM
AF Hunsberger, Joshua G.
   Fessler, Emily B.
   Chibane, Fairouz L.
   Leng, Yan
   Maric, Dragan
   Elkahloun, Abdel G.
   Chuang, De-Maw
TI Mood stabilizer-regulated miRNAs in neuropsychiatric and
   neurodegenerative diseases: identifying associations and functions
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE microRNA; neuroprotection; glutamate excitotoxicity; lithium; valproic
   acid; mood stabilizers
ID SPORADIC ALZHEIMERS-DISEASE; AUTISM SPECTRUM DISORDERS; MICRORNA
   EXPRESSION; VALPROIC ACID; PREFRONTAL CORTEX; HUNTINGTONS-DISEASE;
   ALPHA-SYNUCLEIN; DOWN-REGULATION; RAT MODEL; LITHIUM
AB Identifying mechanisms to enhance neuroprotection holds tremendous promise in developing new treatments for neuropsychiatric and neurodegenerative diseases. We sought to determine the potential role for microRNAs (miRNAs) in neuroprotection following neuronal death. A neuronal culture system of rat cerebellar granule cells was used to examine miRNA expression changes following glutamate-induced excitotoxicity and neuroprotective treatments. Combination treatment with the mood stabilizers lithium and valproic acid provided near-complete protection from glutamate excitotoxicity. Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182, miR-222, miR-495, and miR-690. We then verified the apoptotic actions of miR-34a mimic in a human neuroblastoma cell line (SH-SY5Y) under basal conditions and following endoplasmic reticulum stress. To gain insight into the function of these mood stabilizer-regulated miRNAs, we performed two separate analyses: a candidate approach using Ingenuity Pathway Analysis that was restricted to only our PCR-verified miRNAs, and a global approach using DIANA-mirPath that included all significantly regulated miRNAs. It was observed that the pathways associated with mood stabilizer-regulated miRNAs in our study (global approach) are strongly associated with pathways implicated in neuropsychiatric diseases such as schizophrenia. We also observed an overlap in the mood stabilizer-regulated miRNAs identified from our study along with dysregulated miRNAs in both neuropsychiatric and neurodegenerative disorders. We anticipate that these associations and overlaps implicate critical pathways and miRNAs in disease mechanisms for novel therapeutic treatments that may hold potential for many neurological diseases.
C1 [Hunsberger, Joshua G.; Fessler, Emily B.; Chibane, Fairouz L.; Leng, Yan; Chuang, De-Maw] NIMH, Mol Neurobiol Sect, NIH, Bethesda, MD 20892 USA.
   [Elkahloun, Abdel G.] NHGRI, NIH, Bethesda, MD USA.
   [Maric, Dragan] NINDS, NIH, Bethesda, MD 20892 USA.
RP Chuang, DM (reprint author), NIMH, NIH, 10 Ctr Dr MSC 1363, Bethesda, MD 20892 USA.
EM hunsbergerj@mail.nih.gov; chuang@mail.nih.gov
FU NIMH, NIH
FX We would like to acknowledge the support of the Intramural Research
   Program of the NIMH, NIH. We would also like to acknowledge the
   technical support kindly provided by Weiwei Wu for microRNA array
   processing, and the editorial suggestions by Peter Leeds.
CR Abu-Elneel K, 2008, NEUROGENETICS, V9, P153, DOI 10.1007/s10048-008-0133-5
   Ambros V, 2004, NATURE, V431, P350, DOI 10.1038/nature02871
   Bartel DP, 2004, CELL, V116, P281, DOI 10.1016/S0092-8674(04)00045-5
   Beveridge NJ, 2010, MOL PSYCHIATR, V15, P1176, DOI 10.1038/mp.2009.84
   Beveridge NJ, 2008, HUM MOL GENET, V17, P1156, DOI 10.1093/hmg/ddn005
   Boche D, 2003, J CEREBR BLOOD F MET, V23, P1174, DOI 10.1097/01.WCB.0000090080.64176.44
   Brandenburger T, 2012, NEUROSCI LETT, V506, P281, DOI 10.1016/j.neulet.2011.11.023
   Chen G, 1999, J NEUROCHEM, V72, P879, DOI 10.1046/j.1471-4159.1999.720879.x
   Chen RW, 1999, J BIOL CHEM, V274, P6039, DOI 10.1074/jbc.274.10.6039
   Chiu CT, 2011, NEUROPSYCHOPHARMACOL, V36, P2406, DOI 10.1038/npp.2011.128
   Cogswell JP, 2008, J ALZHEIMERS DIS, V14, P27
   Delay C, 2011, MOL NEURODEGENER, V6, DOI 10.1186/1750-1326-6-70
   Dobolyi A, 2012, INT J MOL SCI, V13, P8219, DOI 10.3390/ijms13078219
   Dweep H, 2011, J BIOMED INFORM, V44, P839, DOI 10.1016/j.jbi.2011.05.002
   Feng HL, 2008, NEUROSCIENCE, V155, P567, DOI 10.1016/j.neuroscience.2008.06.040
   Filipowicz W, 2008, NAT REV GENET, V9, P102, DOI 10.1038/nrg2290
   Gaughwin PM, 2011, HUM MOL GENET, V20, P2225, DOI 10.1093/hmg/ddr111
   Geekiyanage H, 2011, J NEUROSCI, V31, P14820, DOI 10.1523/JNEUROSCI.3883-11.2011
   Geekiyanage H, 2012, EXP NEUROL, V235, P491, DOI 10.1016/j.expneurol.2011.11.026
   Ghose J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023837
   Hashimoto R, 2002, J NEUROCHEM, V80, P589, DOI 10.1046/j.0022-3042.2001.00728.x
   Hebert SS, 2008, P NATL ACAD SCI USA, V105, P6415, DOI 10.1073/pnas.0710263105
   Hillion JA, 2005, J CEREBR BLOOD F MET, V25, P154, DOI 10.1038/sj.jcbfm.9600003
   Hu K, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-115
   Hunsberger JG, 2012, AM J TRANSL RES, V4, P316
   Jiang QH, 2009, NUCLEIC ACIDS RES, V37, pD98, DOI 10.1093/nar/gkn714
   Kan AA, 2012, CELL MOL LIFE SCI, V69, P3127, DOI 10.1007/s00018-012-0992-7
   Kanai H, 2004, PHARMACOGENOMICS J, V4, P336, DOI 10.1038/sj.tpj.6500269
   Khanna A, 2011, AGING-US, V3, P223
   Kim AH, 2010, SCHIZOPHR RES, V124, P183, DOI 10.1016/j.schres.2010.07.002
   Lagos-Quintana M, 2002, CURR BIOL, V12, P735, DOI 10.1016/S0960-9822(02)00809-6
   Lai CY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021635
   Lee ST, 2010, STROKE, V41, P1646, DOI 10.1161/STROKEAHA.110.579649
   Lee YJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047787
   Lehmann SM, 2012, NAT NEUROSCI, V15, P827, DOI 10.1038/nn.3113
   Leng Y, 2010, NEUROSCI LETT, V476, P127, DOI 10.1016/j.neulet.2010.04.013
   Leng Y, 2008, J NEUROSCI, V28, P2576, DOI 10.1523/JNEUROSCI.5467-07.2008
   Leng Y, 2006, J NEUROSCI, V26, P7502, DOI 10.1523/JNEUROSCI.0096-06.2006
   Liang MH, 2008, MOL CELL NEUROSCI, V37, P440, DOI 10.1016/j.mcn.2007.10.017
   Liu G, 2009, P NATL ACAD SCI USA, V106, P15819, DOI 10.1073/pnas.0901216106
   Mallick B, 2011, RNA BIOL, V8, P665, DOI 10.4161/rna.8.4.15584
   Marti E, 2010, NUCLEIC ACIDS RES, V38, P7219, DOI 10.1093/nar/gkq575
   Martins M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025443
   Mellios N, 2008, HUM MOL GENET, V17, P3030, DOI 10.1093/hmg/ddn201
   Minones-Moyano E, 2011, HUM MOL GENET, V20, P3067, DOI 10.1093/hmg/ddr210
   Miranda KC, 2006, CELL, V126, P1203, DOI 10.1016/j.cell.2006.07.031
   Moreau MP, 2011, BIOL PSYCHIAT, V69, P188, DOI 10.1016/j.biopsych.2010.09.039
   Moskwa P, 2011, MOL CELL, V41, P210, DOI 10.1016/j.molcel.2010.12.005
   Nonaka S, 1998, P NATL ACAD SCI USA, V95, P2642, DOI 10.1073/pnas.95.5.2642
   Papadopoulos GL, 2009, BIOINFORMATICS, V25, P1991, DOI 10.1093/bioinformatics/btp299
   Perkins DO, 2007, GENOME BIOL, V8, DOI 10.1186/gb-2007-8-2-r27
   Santarelli DM, 2011, BIOL PSYCHIAT, V69, P180, DOI 10.1016/j.biopsych.2010.09.030
   Sarachana T, 2010, GENOME MED, V2, DOI 10.1186/gm144
   Saus E, 2010, HUM MOL GENET, V19, P4017, DOI 10.1093/hmg/ddq316
   Schipper Hyman M, 2007, Gene Regul Syst Bio, V1, P263
   Schratt GM, 2006, NATURE, V439, P283, DOI 10.1038/nature04367
   Seno MMG, 2011, BRAIN RES, V1380, P85, DOI 10.1016/j.brainres.2010.09.046
   Shioya M, 2010, NEUROPATH APPL NEURO, V36, P320, DOI 10.1111/j.1365-2990.2010.01076.x
   Sinha M, 2010, BIOCHEM BIOPH RES CO, V396, P742, DOI 10.1016/j.bbrc.2010.05.007
   Smalheiser NR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033201
   Sun ZW, 2010, NEUROSCI BULL, V26, P8, DOI 10.1007/s12264-010-0813-7
   Tsai LK, 2010, NEUROPSYCHOPHARMACOL, V35, P2225, DOI 10.1038/npp.2010.97
   Tsai LK, 2011, STROKE, V42, P2932, DOI 10.1161/STROKEAHA.110.612788
   Wang G, 2008, AM J HUM GENET, V82, P283, DOI 10.1016/j.ajhg.2007.09.021
   Wang WX, 2011, ACTA NEUROPATHOL, V121, P193, DOI 10.1007/s00401-010-0756-0
   Wang XY, 2009, BRAIN RES BULL, V80, P268, DOI 10.1016/j.brainresbull.2009.08.006
   Zhou R, 2009, NEUROPSYCHOPHARMACOL, V34, P1395, DOI 10.1038/npp.2008.131
   Zhou SL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044768
NR 68
TC 10
Z9 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2013
VL 5
IS 4
BP 450
EP U113
PG 16
WC Oncology; Medicine, Research & Experimental
SC Oncology; Research & Experimental Medicine
GA 172EP
UT WOS:000320983100007
PM 23724168
ER

PT J
AU Gorgoni, M
   D'Atri, A
   Lauri, G
   Rossini, PM
   Ferlazzo, F
   De Gennaro, L
AF Gorgoni, Maurizio
   D'Atri, Aurora
   Lauri, Giulia
   Rossini, Paolo Maria
   Ferlazzo, Fabio
   De Gennaro, Luigi
TI Is Sleep Essential for Neural Plasticity in Humans, and How Does It
   Affect Motor and Cognitive Recovery?
SO NEURAL PLASTICITY
LA English
DT Review
ID SLOW-WAVE SLEEP; TRANSCRANIAL MAGNETIC STIMULATION; DECLARATIVE MEMORY
   CONSOLIDATION; PAIRED ASSOCIATIVE STIMULATION; JUVENILE MYOCLONIC
   EPILEPSY; AUTISM SPECTRUM DISORDERS; FOCAL CEREBRAL-ISCHEMIA; LONG-TERM
   POTENTIATION; BRAIN GENE-EXPRESSION; NON-REM SLEEP
AB There is a general consensus that sleep is strictly linked to memory, learning, and, in general, to the mechanisms of neural plasticity, and that this link may directly affect recovery processes. In fact, a coherent pattern of empirical findings points to beneficial effect of sleep on learning and plastic processes, and changes in synaptic plasticity during wakefulness induce coherent modifications in EEG slow wave cortical topography during subsequent sleep. However, the specific nature of the relation between sleep and synaptic plasticity is not clear yet. We reported findings in line with two models conflicting with respect to the underlying mechanisms, that is, the "synaptic homeostasis hypothesis" and the "consolidation" hypothesis, and some recent results that may reconcile them. Independently from the specific mechanisms involved, sleep loss is associated with detrimental effects on plastic processes at a molecular and electrophysiological level. Finally, we reviewed growing evidence supporting the notion that plasticity-dependent recovery could be improved managing sleep quality, while monitoring EEG during sleep may help to explain how specific rehabilitative paradigms work. We conclude that a better understanding of the sleep-plasticity link could be crucial from a rehabilitative point of view.
C1 [Gorgoni, Maurizio; D'Atri, Aurora; Lauri, Giulia; Ferlazzo, Fabio; De Gennaro, Luigi] Univ Roma La Sapienza, Dept Psychol, I-00185 Rome, Italy.
   [Rossini, Paolo Maria] Univ Cattolica Sacro Cuore, Inst Neurol, I-00168 Rome, Italy.
   [Rossini, Paolo Maria; De Gennaro, Luigi] IRCCS San Raffaele Pisana, I-00163 Rome, Italy.
   [Ferlazzo, Fabio] IRCCS Fdn Santa Lucia, I-00179 Rome, Italy.
RP De Gennaro, L (reprint author), Univ Roma La Sapienza, Dept Psychol, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
EM luigi.degennaro@uniroma1.it
RI Rossini, Paolo /D-4994-2013
OI Rossini, Paolo /0000-0003-2665-534X
FU "Finanziamenti per Progetti di Ricerca anno-"Sapienza" Universita di
   Roma" [C26A10AP8N]
FX The authors are grateful for support from "Finanziamenti per Progetti di
   Ricerca anno 2010-"Sapienza" Universita di Roma" Project no. C26A10AP8N
   to Luigi De Gennaro.
CR Aeschbach D, 1997, NEUROSCI LETT, V239, P121, DOI 10.1016/S0304-3940(97)00904-X
   Andersen IM, 2008, J CHILD NEUROL, V23, P482, DOI 10.1177/0883073807309783
   Aton SJ, 2009, NEURON, V61, P454, DOI 10.1016/j.neuron.2009.01.007
   Attwell D, 2001, J CEREBR BLOOD F MET, V21, P1133
   Babiloni C, 2004, EUR J NEUROSCI, V19, P2583, DOI 10.1111/j.1460-9568.2004.03333.x
   Babiloni C, 2006, BRAIN RES BULL, V69, P63, DOI 10.1016/j.brainresbull.2005.10.013
   Backhaus J, 2006, BIOL PSYCHIAT, V60, P1324, DOI 10.1016/j.biopsych.2006.03.051
   Badawy RAB, 2006, NEUROLOGY, V67, P1018, DOI 10.1212/01.wnl.0000237392.64230.f7
   Basheer R, 2005, J NEUROSCI RES, V82, P650, DOI 10.1002/jnr.20675
   Baumann CR, 2006, SLEEP, V29, P1339
   Beebe DW, 2003, SLEEP, V26, P298
   Beldarrain MG, 2008, CLIN NEUROL NEUROSUR, V110, P245, DOI 10.1016/j.clineuro.2007.11.004
   Bergmann TO, 2008, EUR J NEUROSCI, V27, P2241, DOI 10.1111/j.1460-9568.2008.06178.x
   Bonnet MH, 2003, SLEEP MED REV, V7, P297, DOI 10.1053/smrv.2001.0245
   Borbely AA, 2001, ARCH ITAL BIOL, V139, P53
   Born J, 2012, NEURON, V75, P933, DOI 10.1016/j.neuron.2012.09.007
   Born J, 2006, NEUROSCIENTIST, V12, P410, DOI 10.1177/1073858406292647
   Born J, 2004, TRENDS COGN SCI, V8, P242, DOI 10.1016/S1364-6613(04)00110-X
   Born J, 2012, PSYCHOL RES-PSYCH FO, V76, P192, DOI 10.1007/s00426-011-0335-6
   Braun AR, 1997, BRAIN, V120, P1173, DOI 10.1093/brain/120.7.1173
   Bushey D, 2011, SCIENCE, V332, P1576, DOI 10.1126/science.1202839
   Cajochen C, 1999, Sleep Res Online, V2, P65
   Cajochen C, 1995, SLEEP, V18, P890
   Campbell IG, 2002, J NEUROPHYSIOL, V88, P1073, DOI 10.1152/jn.00873.2001
   Cardinali DP, 2010, CURR NEUROPHARMACOL, V8, P218, DOI 10.2174/157015910792246209
   Carmichael ST, 2008, STROKE, V39, P1380, DOI 10.1161/STROKEAHA.107.499962
   Carmichael ST, 2010, NEUROBIOL DIS, V37, P237, DOI 10.1016/j.nbd.2009.09.005
   Carr MF, 2011, NAT NEUROSCI, V14, P147, DOI 10.1038/nn.2732
   Cellerino A, 1996, EUR J NEUROSCI, V8, P1190, DOI 10.1111/j.1460-9568.1996.tb01287.x
   Chauvette S, 2012, NEURON, V75, P1105, DOI 10.1016/j.neuron.2012.08.034
   Chopp M, 2009, STROKE, V40, pS143, DOI 10.1161/STROKEAHA.108.533141
   Cirelli C, 2005, J NEUROSCI, V25, P4503, DOI 10.1523/JNEUROSCI.4845-04.2005
   Cirelli C, 2004, NEURON, V41, P35, DOI 10.1016/S0896-6273(03)00814-6
   Cirelli C, 2000, J NEUROSCI, V20, P9187
   Cirelli C, 1996, SCIENCE, V274, P1211, DOI 10.1126/science.274.5290.1211
   Cirelli C, 2000, BRAIN RES, V885, P303, DOI 10.1016/S0006-8993(00)03008-0
   Cirelli C, 2006, SLEEP MED REV, V10, P307, DOI 10.1016/j.smrv.2006.04.001
   Civardi C, 2001, J NEUROL NEUROSUR PS, V71, P809, DOI 10.1136/jnnp.71.6.809
   Clemens Z, 2006, NEUROSCI LETT, V403, P52, DOI 10.1016/j.neulet.2006.04.035
   Clemens Z, 2005, NEUROSCIENCE, V132, P529, DOI 10.1016/j.neuroscience.2005.01.011
   Clemens Zsófia, 2011, Eur J Neurosci, V33, P511, DOI 10.1111/j.1460-9568.2010.07505.x
   Cortesi F, 2010, SLEEP MED, V11, P659, DOI 10.1016/j.sleep.2010.01.010
   Csernus V, 2004, GEN COMP ENDOCR, V135, P62, DOI 10.1016/S0016-6480(03)00284-3
   Czikk MJ, 2003, AM J PHYSIOL-REG I, V284, pR200, DOI 10.1152/ajpregu.00190.2002
   Dash MB, 2009, J NEUROSCI, V29, P580, DOI 10.1523/JNEUROSCI.5486-08.2009
   Dave AS, 2000, SCIENCE, V290, P812, DOI 10.1126/science.290.5492.812
   De Gennaro L., 2008, PLOS ONE, V3
   de Manaceine M., 1894, ARCH ITAL BIOL, V21, P322
   DEEGAN PC, 1995, EUR RESPIR J, V8, P1161, DOI 10.1183/09031936.95.08071161
   De Gennaro L, 2007, NEUROIMAGE, V36, P1277, DOI 10.1016/j.neuroimage.2007.04.013
   Del Felice A, 2011, EPILEPSY RES, V96, P123, DOI 10.1016/j.eplepsyres.2011.05.015
   Deregnaucourt S, 2005, NATURE, V433, P710, DOI 10.1038/nature03275
   Diekelmann S, 2010, NAT REV NEUROSCI, V11, P114, DOI 10.1038/nrn2762
   Dierks T, 2000, CLIN NEUROPHYSIOL, V111, P1817, DOI 10.1016/S1388-2457(00)00427-2
   DIERKS T, 1993, PSYCHIAT RES-NEUROIM, V50, P151, DOI 10.1016/0925-4927(93)90027-F
   Dinges DF, 1997, SLEEP, V20, P267
   Durmer JS, 2005, SEMIN NEUROL, V25, P117, DOI 10.1055/s-2005-867080
   Engleman HM, 2000, SLEEP, V23, pS102
   Eschenko O, 2008, CEREB CORTEX, V18, P2596, DOI 10.1093/cercor/bhn020
   Eschenko O, 2012, CEREB CORTEX, V22, P426, DOI 10.1093/cercor/bhr121
   Euston DR, 2007, SCIENCE, V318, P1147, DOI 10.1126/science.1148979
   Faraguna U, 2008, J NEUROSCI, V28, P4088, DOI 10.1523/JNEUROSCI.5510-07.2008
   Ferrara M, 2002, CEREB CORTEX, V12, P737, DOI 10.1093/cercor/12.7.737
   Fogel SM, 2007, BEHAV BRAIN RES, V180, P48, DOI 10.1016/j.bbr.2007.02.037
   Frank MG, 2012, NEURAL PLAST, DOI 10.1155/2012/264378
   Frank MG, 2001, NEURON, V30, P275, DOI 10.1016/S0896-6273(01)00279-3
   Gagnon JF, 2006, SLEEP, V29, P1321
   Gais S, 2004, LEARN MEMORY, V11, P679, DOI 10.1101/lm.80504
   Gais S, 2000, NAT NEUROSCI, V3, P1335
   Gao B, 2010, SLEEP, V33, P879
   Gao B, 2008, CEREBROVASC DIS, V26, P413, DOI 10.1159/000151683
   Ghilardi MF, 2000, BRAIN RES, V871, P127, DOI 10.1016/S0006-8993(00)02365-9
   Giannotti F, 2008, SLEEP, V31, pA58
   Giannotti F, 2008, J AUTISM DEV DISORD, V38, P1888, DOI 10.1007/s10803-008-0584-4
   Gilestro GF, 2009, SCIENCE, V324, P109, DOI 10.1126/science.1166673
   GIUDITTA A, 1995, BEHAV BRAIN RES, V69, P157, DOI 10.1016/0166-4328(95)00012-I
   Gozal D, 2001, J NEUROSCI, V21, P2442
   Grosmark AD, 2012, NEURON, V75, P1001, DOI 10.1016/j.neuron.2012.08.015
   Guzowski JF, 2001, J NEUROSCI, V21, P5089
   Hanlon EC, 2009, SLEEP, V32, P719
   Hassainia F, 1997, EUR NEUROL, V37, P219, DOI 10.1159/000117446
   Hermann DM, 2009, NEUROLOGY, V73, P1313, DOI 10.1212/WNL.0b013e3181bd137c
   Hill S, 2005, J NEUROPHYSIOL, V93, P1671, DOI 10.1152/jn.00915.2004
   Huang C, 2000, CLIN NEUROPHYSIOL, V111, P1961, DOI 10.1016/S1388-2457(00)00454-5
   Huber R, 2004, NATURE, V430, P78, DOI 10.1038/nature02663
   Huber R, 2007, PLOS ONE, V2
   Huber R, 2006, NAT NEUROSCI, V9, P1169, DOI 10.1038/nn1758
   Huber R, 2008, J NEUROSCI, V28, P7911, DOI 10.1523/JNEUROSCI.1636-08.2008
   Huber R., 2012, CEREB CORTEX, V23, P1
   Huber R, 2007, SLEEP, V30, P129
   Jelic V, 2000, NEUROBIOL AGING, V21, P533, DOI 10.1016/S0197-4580(00)00153-6
   Ji DY, 2007, NAT NEUROSCI, V10, P100, DOI 10.1038/nn1825
   Kalinchuk AV, 2003, EUR J NEUROSCI, V17, P863, DOI 10.1046/j.1460-9568.2003.02532.x
   Kang JE, 2009, SCIENCE, V326, P1005, DOI 10.1126/science.1180962
   Kelly MP, 2003, J NEUROSCI, V23, P6443
   Kemp N, 2001, PROG NEUROBIOL, V65, P339, DOI 10.1016/S0301-0082(01)00013-2
   Kern JK, 2004, EXPERT OPIN PHARMACO, V5, P379, DOI 10.1517/eoph.5.2.379.26488
   Kertesz A., 1982, W APHASIA BATTERY
   Kleim JA, 1996, J NEUROSCI, V16, P4529
   Knott GW, 2002, NEURON, V34, P265, DOI 10.1016/S0896-6273(02)00663-3
   Kopp C, 2006, J NEUROSCI, V26, P12456, DOI 10.1523/JNEUROSCI.2702-06.2006
   Kotgal S., 2012, PEDIAT NEUROLOGY, V47, P242
   Kreuzer P, 2011, NEUROSCI LETT, V493, P63, DOI 10.1016/j.neulet.2011.02.044
   Kulman G, 2000, NEUROENDOCRINOL LETT, V21, P31
   Kylstra W. A., 2012, SLEEP MED REV
   Lee J, 2010, APHASIOLOGY, V24, P449, DOI 10.1080/02687030802714157
   Leu RM, 2011, J AUTISM DEV DISORD, V41, P427, DOI 10.1007/s10803-010-1072-1
   Levy P, 2008, EUR RESPIR J, V32, P1082, DOI 10.1183/09031936.00013308
   Lim D. C., 2013, SLEEP MED REV
   Liu ZW, 2010, J NEUROSCI, V30, P8671, DOI 10.1523/JNEUROSCI.1409-10.2010
   Lu Y, 2008, NEUROBIOL LEARN MEM, V89, P312, DOI 10.1016/j.nlm.2007.08.018
   Magistretti P.J., 1999, FUNDAMENTAL NEUROSCI, P389
   Malow Beth A, 2004, Epilepsy Curr, V4, P193, DOI 10.1111/j.1535-7597.2004.04509.x
   Manganotti P, 2006, J NEUROL NEUROSUR PS, V77, P56, DOI 10.1136/jnnp.2004.041137
   Manganotti P, 2001, NEUROSCI LETT, V304, P153, DOI 10.1016/S0304-3940(01)01783-9
   Maquet P, 2000, NAT NEUROSCI, V3, P831, DOI 10.1038/77744
   MARIORENZI R, 1991, ELECTROEN CLIN NEURO, V81, P90, DOI 10.1016/0168-5597(91)90002-F
   Marshall L, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016905
   Marshall L, 2006, NATURE, V444, P610, DOI 10.1038/nature05278
   Marshall L, 2004, J NEUROSCI, V24, P9985, DOI 10.1523/JNEUROSCI.2725-04.2004
   Marzano C, 2010, J SLEEP RES, V19, P260, DOI 10.1111/j.1365-2869.2009.00776.x
   Massimini M, 2004, J NEUROSCI, V24, P6862, DOI 10.1523/JNEUROSCI.1318-04.2004
   Massimini M, 2007, P NATL ACAD SCI USA, V104, P8496, DOI 10.1073/pnas.0702495104
   McCoy JG, 2011, NEUROBIOL LEARN MEM, V96, P564, DOI 10.1016/j.nlm.2011.07.004
   McDermott CM, 2003, J NEUROSCI, V23, P9687
   Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016
   Molle M, 2009, NEURON, V61, P496, DOI 10.1016/j.neuron.2009.02.002
   MONTPLAISIR J, 1995, SLEEP, V18, P145
   Montplaisir J, 1998, Sleep Res Online, V1, P147
   Ngo HVV, 2013, NEURON, V78, P545, DOI 10.1016/j.neuron.2013.03.006
   Nissen C, 2011, J SLEEP RES, V20, P129, DOI 10.1111/j.1365-2869.2010.00872.x
   Nissen C, 2006, SLEEP, V29, P1068
   Ohayon MM, 2004, SLEEP, V27, P1255
   Olcese U, 2010, J NEUROPHYSIOL, V104, P3476, DOI 10.1152/jn.00593.2010
   Osorio RS, 2011, J AM GERIATR SOC, V59, P559, DOI 10.1111/j.1532-5415.2010.03288.x
   Parish JM, 2004, MAYO CLIN PROC, V79, P1036
   Peigneux P, 2004, NEURON, V44, P535, DOI 10.1016/j.neuron.2004.10.007
   Petit D., 2005, PRINCIPLES PRACTICE, P853, DOI 10.1016/B0-72-160797-7/50078-1
   Petit D, 2004, J PSYCHOSOM RES, V56, P487, DOI 10.1016/j.jpsychores.2004.02.001
   Piosczyk H., 2013, J SLEEP RES
   Plihal W, 1997, J COGNITIVE NEUROSCI, V9, P534, DOI 10.1162/jocn.1997.9.4.534
   Polimeni MA, 2005, J INTELL DISABIL RES, V49, P260, DOI 10.1111/j.1365-2788.2005.00642.x
   Poo MM, 2001, NAT REV NEUROSCI, V2, P24, DOI 10.1038/35049004
   Porkka-Heiskanen T, 2011, SLEEP MED REV, V15, P123, DOI 10.1016/j.smrv.2010.06.005
   Rasch B, 2007, SCIENCE, V315, P1426, DOI 10.1126/science.1138581
   Rauchs G, 2005, J SLEEP RES, V14, P123, DOI 10.1111/j.1365-2869.2005.00450.x
   RECHTSCHAFFEN A, 1995, BEHAV BRAIN RES, V69, P55, DOI 10.1016/0166-4328(95)00020-T
   Rechtschaffen A., 1971, HUMAN BEHAV ITS CONT, P88
   Ribeiro S, 1999, LEARN MEMORY, V6, P500, DOI 10.1101/lm.6.5.500
   Ribeiro S, 2002, J NEUROSCI, V22, P10914
   Richdale AL, 2009, SLEEP MED REV, V13, P403, DOI 10.1016/j.smrv.2009.02.003
   Sanchez AI, 2009, SLEEP MED REV, V13, P223, DOI 10.1016/j.smrv.2008.07.002
   Sanchez-Huertas C, 2011, CEREB CORTEX, V21, P777, DOI 10.1093/cercor/bhq150
   Sarasso S, 2010, ARCH ITAL BIOL, V148, P271
   Schmidt C, 2006, J NEUROSCI, V26, P8976, DOI 10.1523/JNEUROSCI.2464-06.2006
   Shepherd JD, 2011, NAT NEUROSCI, V14, P279, DOI 10.1038/nn.2708
   Siengsukon C, 2009, NEUROREHAB NEURAL RE, V23, P327, DOI 10.1177/1545968308326631
   Siengsuhon CF, 2008, TOP STROKE REHABIL, V15, P1, DOI 10.1310/tsr1501-1
   Siengsukon CF, 2009, NEUROSCI LETT, V451, P1, DOI 10.1016/j.neulet.2008.12.040
   Siengsukon CF, 2009, PHYS THER, V89, P370, DOI 10.2522/ptj.20080310
   Stefan K, 2000, BRAIN, V123, P572, DOI 10.1093/brain/123.3.572
   Steriade M, 2003, FRONT BIOSCI, V8, pD878, DOI 10.2741/1043
   Stickgold R, 2005, NATURE, V437, P1272, DOI 10.1038/nature04286
   Terney D, 2005, NEUROSCI LETT, V383, P82, DOI 10.1016/j.neulet.2005.03.047
   Tononi G, 2006, SLEEP MED REV, V10, P49, DOI 10.1016/j.smrv.2005.05.002
   Cirelli C, 2008, PLOS BIOL, V6, P1605, DOI 10.1371/journal.pbio.0060216
   Tononi G, 2003, BRAIN RES BULL, V62, P143, DOI 10.1016/j.brainresbull.2003.09.004
   Tucker MA, 2006, NEUROBIOL LEARN MEM, V86, P241, DOI 10.1016/j.nlm.2006.03.005
   VanCauter E, 1997, J CLIN INVEST, V100, P745, DOI 10.1172/JCI119587
   Voderholzer U, 2011, SLEEP MED, V12, P170, DOI 10.1016/j.sleep.2010.07.017
   Vyazovskiy VV, 2013, J SLEEP RES, V22, P239, DOI 10.1111/jsr.12009
   Vyazovskiy VV, 2009, NEURON, V63, P865, DOI 10.1016/j.neuron.2009.08.024
   Vyazovskiy VV, 2008, NAT NEUROSCI, V11, P200, DOI 10.1038/nn2035
   Walker MP, 2008, SLEEP MED, V9, pS29, DOI 10.1016/S1389-9457(08)70014-5
   Walker MP, 2005, BEHAV BRAIN SCI, V28, P51, DOI 10.1017/S0140525X05000026
   Walker MP, 2002, NEURON, V35, P205, DOI 10.1016/S0896-6273(02)00746-8
   Wang H, 2012, NEURAL PLAST, DOI 10.1155/2012/272374
   Weaver TE, 2007, SLEEP MED REV, V11, P99, DOI 10.1016/j.smrv.2006.08.001
   Welch MG, 2004, CELL MOL NEUROBIOL, V24, P219, DOI 10.1023/B:CEMN.0000018618.59015.a2
   Wierzynski CM, 2009, NEURON, V61, P587, DOI 10.1016/j.neuron.2009.01.011
   WILSON MA, 1994, SCIENCE, V265, P676, DOI 10.1126/science.8036517
   Wolters A, 2005, J PHYSIOL-LONDON, V565, P1039, DOI 10.1113/jphysiol.2005.084954
   Xie H, 2010, NEUROBIOL DIS, V40, P155, DOI 10.1016/j.nbd.2010.05.020
   Xie H, 2012, ACTA PHARMACOL SIN, V33, P5, DOI 10.1038/aps.2011.184
   Yamashita Y, 1999, BRAIN DEV-JPN, V21, P570
   Yun AJ, 2004, MED HYPOTHESES, V63, P939, DOI 10.1016/j.mehy.2004.07.027
   Zunzunegui C, 2011, SLEEP, V34, P1261, DOI 10.5665/SLEEP.1252
NR 187
TC 1
Z9 1
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 0792-8483
J9 NEURAL PLAST
JI Neural. Plast.
PY 2013
AR 103949
DI 10.1155/2013/103949
PG 13
WC Neurosciences
SC Neurosciences & Neurology
GA 169SX
UT WOS:000320801700001
ER

PT J
AU Signorini, C
   De Felice, C
   Durand, T
   Oger, C
   Galano, JM
   Leoncini, S
   Pecorelli, A
   Valacchi, G
   Ciccoli, L
   Hayek, J
AF Signorini, Cinzia
   De Felice, Claudio
   Durand, Thierry
   Oger, Camille
   Galano, Jean-Marie
   Leoncini, Silvia
   Pecorelli, Alessandra
   Valacchi, Giuseppe
   Ciccoli, Lucia
   Hayek, Joussef
TI Isoprostanes and 4-Hydroxy-2-nonenal: Markers or Mediators of Disease?
   Focus on Rett Syndrome as a Model of Autism Spectrum Disorder
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID MILD COGNITIVE IMPAIRMENT; THROMBOXANE A(2) RECEPTOR; OXIDATIVE STRESS;
   ALZHEIMERS-DISEASE; LIPID-PEROXIDATION; IN-VIVO; DOCOSAHEXAENOIC ACID;
   BRAIN PROTEINS; F-2-ISOPROSTANES; PRODUCTS
AB Lipid peroxidation, a process known to induce oxidative damage to key cellular components, has been implicated in several diseases. Following three decades of explorations mainly on in vitro models reproducible in the laboratories, lipid peroxidation has become increasingly relevant for the interpretation of a wide range of pathophysiological mechanisms in the clinical setting. This cumulative effort has led to the identification of several lipid peroxidation end-products meeting the needs of the in vivo evaluation. Among these different molecules, isoprostanes and 4-hydroxy-2-nonenal protein adducts appear to be particularly interesting. This review shows how specific oxidation products, deriving from polyunsaturated fatty acids precursors, are strictly related to the clinical manifestations and the natural history of Rett syndrome, a genetically determined neurodevelopmental pathology, currently classified among the autism spectrum disorders. In our experience, Rett syndrome offers a unique setting for physicians, biologists, and chemists to explore the borders of the lipid mediators concept.
C1 [Signorini, Cinzia; Leoncini, Silvia; Pecorelli, Alessandra; Ciccoli, Lucia] Univ Siena, Dept Mol & Dev Med, I-53100 Siena, Italy.
   [De Felice, Claudio] Azienda Osped Univ Senese, Univ Gen Hosp, Neonatal Intens Care Unit, I-53100 Siena, Italy.
   [Durand, Thierry; Oger, Camille; Galano, Jean-Marie] UM II, UM 1, CNRS, IBMM,UMR 5247, F-34093 Montpellier 5, France.
   [Leoncini, Silvia; Pecorelli, Alessandra; Hayek, Joussef] Azienda Osped Univ Senese, Univ Gen Hosp, Child Neuropsychiat Unit, I-53100 Siena, Italy.
   [Valacchi, Giuseppe] Univ Ferrara, Dept Life Sci & Biotechnol, I-44121 Ferrara, Italy.
   [Valacchi, Giuseppe] Kyung Hee Univ, Dept Food & Nutr, Seoul 130701, South Korea.
RP Signorini, C (reprint author), Univ Siena, Dept Mol & Dev Med, Via Laterina 8, I-53100 Siena, Italy.
EM cinzia.signorini@unisi.it
CR Aluise CD, 2011, J ALZHEIMERS DIS, V23, P257, DOI 10.3233/JAD-2010-101083
   Al-Yafee Y. A., 2011, BMC NEUROLOGY, V11
   Amir RE, 1999, NAT GENET, V23, P185
   ATSMON J, 1990, BIOCHEMISTRY-US, V29, P3760, DOI 10.1021/bi00467a023
   Bannenberg GL, 2010, THESCIENTIFICWORLDJO, V10, P676, DOI 10.1100/tsw.2010.57
   Basu S, 2010, MOL CELLS, V30, P383, DOI 10.1007/s10059-010-0157-1
   Basu S, 2008, ANTIOXID REDOX SIGN, V10, P1405, DOI [10.1089/ars.2007.1956, 10.1086/ars.2007.1956]
   Basu S, 2010, PROSTAG LEUKOTR ESS, V82, P219, DOI 10.1016/j.plefa.2010.02.031
   Benndorf RA, 2008, CIRC RES, V103, P1037, DOI 10.1161/CIRCRESAHA.108.184036
   Bowers K, 2011, J NEURODEV DISORD, V3, P132, DOI 10.1007/s11689-011-9077-4
   BOYLAND E, 1968, BIOCHEM J, V109, P651
   Brazil JC, 2013, INFLAMM BOWEL DIS, V19, P1556, DOI 10.1097/MIB.0b013e318281f54e
   Brinkmann Y, 2010, J ORG CHEM, V75, P2411, DOI 10.1021/jo1000274
   Brooks JD, 2011, J NEUROCHEM, V119, P604, DOI 10.1111/j.1471-4159.2011.07422.x
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Chen Y, 1999, J BIOL CHEM, V274, P10863, DOI 10.1074/jbc.274.16.10863
   Ciccoli L, 2012, BBA-GEN SUBJECTS, V1820, P511, DOI 10.1016/j.bbagen.2011.12.002
   Corcoran TB, 2011, ANTIOXID REDOX SIGN, V15, P2663, DOI 10.1089/ars.2011.4125
   De Felice C, 2009, FREE RADICAL BIO MED, V47, P440, DOI 10.1016/j.freeradbiomed.2009.05.016
   De Felice C, 2012, GENES NUTR, V7, P447, DOI 10.1007/s12263-012-0285-7
   De Felice C, 2011, J LIPID RES, V52, P2287, DOI 10.1194/jlr.P017798
   Derecki NC, 2012, NATURE, V484, P105, DOI 10.1038/nature10907
   Dubinina EE, 2010, BIOCHEMISTRY-MOSCOW+, V75, P1069, DOI 10.1134/S0006297910090014
   El Fangour S, 2005, J ORG CHEM, V70, P989, DOI 10.1021/jo048179+
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Ferguson LR, 2010, MUTAT RES-FUND MOL M, V690, P3, DOI 10.1016/j.mrfmmm.2010.03.007
   FUKUNAGA M, 1993, AM J PHYSIOL, V264, pC1619
   Galano J.M., 2013, PROSTAGLANDINS OTHER
   Grillo E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056599
   Grune Tilman, 2003, Molecular Aspects of Medicine, V24, P195, DOI 10.1016/S0098-2997(03)00014-1
   Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico, 1999, Lancet, V354, P447, Patent No. [123065193, 5-EP12306519]
   Guy J, 2011, ANNU REV CELL DEV BI, V27, P631, DOI 10.1146/annurev-cellbio-092910-154121
   HAGBERG B, 1983, ANN NEUROL, V14, P471, DOI 10.1002/ana.410140412
   Halliwell B, 2012, NUTR REV, V70, P257, DOI 10.1111/j.1753-4887.2012.00476.x
   Halliwell B, 2011, TRENDS PHARMACOL SCI, V32, P125, DOI 10.1016/j.tips.2010.12.002
   Halliwell B, 2010, ANTIOXID REDOX SIGN, V13, P145, DOI 10.1089/ars.2009.2934
   Halliwell B, 2007, BIOCHEM J, V401, P1, DOI 10.1042/BJ20061131
   Halliwell B., 2007, FREE RADICALS BIOL M
   Halliwell B, 2006, J NEUROCHEM, V97, P1634, DOI 10.1111/j.1471-4159.2006.03907.x
   Hsieh YP, 2009, FREE RADICAL BIO MED, V47, P814, DOI 10.1016/j.freeradbiomed.2009.06.026
   HWANG SW, 1994, J AM CHEM SOC, V116, P10829, DOI 10.1021/ja00102a076
   Jahn U, 2008, ANGEW CHEM INT EDIT, V47, P5894, DOI 10.1002/anie.200705122
   Jamil J, 2012, NEUROCHEM RES, V37, P574, DOI 10.1007/s11064-011-0645-5
   Janssen LJ, 2001, AM J PHYSIOL-LUNG C, V280, pL1067
   Kadiiska MB, 2005, FREE RADICAL BIO MED, V38, P711, DOI 10.1016/freeradbiomed.2004.10.024
   Kadiiska MB, 2005, FREE RADICAL BIO MED, V38, P698, DOI 10.1016/j.freeradbiomed.2004.09.017
   Kepp KP, 2012, CHEM REV, V112, P5193, DOI 10.1021/cr300009x
   Khasawneh FT, 2008, BIOCHEM PHARMACOL, V75, P2301, DOI 10.1016/j.bcp.2008.03.014
   Lehman NL, 2009, ACTA NEUROPATHOL, V118, P329, DOI 10.1007/s00401-009-0560-x
   Leoncini S, 2011, REDOX REP, V16, P145, DOI 10.1179/1351000211Y.0000000004
   Lucantoni G, 2006, ANTIOXID REDOX SIGN, V8, P1171, DOI 10.1089/ars.2006.8.1171
   Meguid NA, 2011, BIOL TRACE ELEM RES, V143, P58, DOI 10.1007/s12011-010-8840-9
   Milne GL, 2004, CHEM RES TOXICOL, V17, P17, DOI 10.1021/tx034213o
   Milne GL, 2005, BIOMARKERS, V10, P10, DOI 10.1080/13547500500216546
   Milne GL, 2011, CHEM REV, V111, P5973, DOI 10.1021/cr200160h
   Minetti M, 2008, ANTIOXID REDOX SIGN, V10, P829, DOI 10.1089/ars.2007.1864
   Montero A, 2000, KIDNEY INT, V58, P1963, DOI 10.1046/j.1523-1755.2000.00368.x
   Montine KS, 2004, CHEM PHYS LIPIDS, V128, P117, DOI 10.1016/j.chemphyslip.2003.10.010
   Montine TJ, 2002, ANN NEUROL, V52, P175, DOI 10.1002/ana.10272
   Montuschi P, 2004, FASEB J, V18, P1791, DOI 10.1096/fj.04-2330rev
   MORROW JD, 1990, ANAL BIOCHEM, V184, P1, DOI 10.1016/0003-2697(90)90002-Q
   MORROW JD, 1994, J BIOL CHEM, V269, P4317
   Morrow JD, 1999, ANAL BIOCHEM, V269, P326, DOI 10.1006/abio.1999.4008
   MORROW JD, 1990, P NATL ACAD SCI USA, V87, P9383, DOI 10.1073/pnas.87.23.9383
   MORROW JD, 1992, P NATL ACAD SCI USA, V89, P10721, DOI 10.1073/pnas.89.22.10721
   Neul JL, 2010, ANN NEUROL, V68, P944, DOI 10.1002/ana.22124
   Nourooz-Zadeh J, 1999, J NEUROCHEM, V72, P734, DOI 10.1046/j.1471-4159.1999.0720734.x
   Oger C, 2012, EUR J ORG CHEM, P2621, DOI 10.1002/ejoc.201200070
   Oger C, 2008, ORG LETT, V10, P5087, DOI 10.1021/ol802104z
   Pagano G, 2012, ADV EXP MED BIOL, V724, P291, DOI 10.1007/978-1-4614-0653-2_22
   Pecorelli A, 2011, CLIN BIOCHEM, V44, P368, DOI 10.1016/j.clinbiochem.2011.01.007
   Perluigi M, 2009, PROTEOM CLIN APPL, V3, P682, DOI 10.1002/prca.200800161
   Petersen DR, 2004, FREE RADICAL BIO MED, V37, P937, DOI 10.1016/j.freeradbiomed.2004.06.012
   Pinot E, 2008, J ORG CHEM, V73, P3063, DOI 10.1021/jo702455g
   Poli G, 2008, MED RES REV, V28, P569, DOI 10.1002/med.20117
   Pratico D, 2010, BBA-MOL CELL BIOL L, V1801, P930, DOI 10.1016/j.bbalip.2010.01.009
   Quan LG, 2002, J AM CHEM SOC, V124, P12424, DOI 10.1021/ja027451z
   Reed T, 2008, NEUROBIOL DIS, V30, P107, DOI 10.1016/j.nbd.2007.12.007
   Roberts LJ, 2002, CELL MOL LIFE SCI, V59, P808, DOI 10.1007/s00018-002-8469-8
   Roberts LJ, 2000, FREE RADICAL BIO MED, V28, P505, DOI 10.1016/S0891-5849(99)00264-6
   Roberts LJ, 1998, J BIOL CHEM, V273, P13605, DOI 10.1074/jbc.273.22.13605
   RONDOT B, 1995, J CHEM SOC PERK T 2, P1589, DOI 10.1039/p29950001589
   SASTRY PS, 1985, PROG LIPID RES, V24, P69, DOI 10.1016/0163-7827(85)90011-6
   Schrader TO, 2002, J AM CHEM SOC, V124, P10998, DOI 10.1021/ja027154u
   Serhan CN, 2010, AM J PATHOL, V177, P1576, DOI 10.2353/ajpath.2010.100322
   Sierra C, 2001, BRAIN DEV-JPN, V23, pS236, DOI 10.1016/S0387-7604(01)00369-2
   Signorini C, 2011, CLIN CHIM ACTA, V412, P1399, DOI 10.1016/j.cca.2011.04.016
   Signorini C, 2009, J PINEAL RES, V46, P148, DOI 10.1111/j.1600-079X.2008.00639.x
   Taber DF, 2008, J ORG CHEM, V73, P3467, DOI 10.1021/jo702600v
   TAKAHASHI K, 1992, J CLIN INVEST, V90, P136, DOI 10.1172/JCI115826
   Ting H. J., 2010, J BIOMEDICAL SCI, V17
   Uchida K, 2003, PROG LIPID RES, V42, P318, DOI 10.1016/S0163-7827(03)00014-6
   VanRollins M, 2008, J LIPID RES, V49, P995, DOI 10.1194/jlr.M700503-JLR200
   Yura T, 1999, KIDNEY INT, V56, P471, DOI 10.1046/j.1523-1755.1999.00596.x
   Zaja-Milatovic S, 2008, NEUROTOXICOLOGY, V29, P621, DOI 10.1016/j.neuro.2008.04.009
   Zaja-Milatovic S, 2009, TOXICOL APPL PHARM, V240, P124, DOI 10.1016/j.taap.2009.07.006
   Zanoni G, 2002, J ORG CHEM, V67, P4346, DOI 10.1021/jo025652f
NR 98
TC 1
Z9 1
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1942-0900
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2013
DI 10.1155/2013/343824
PG 10
WC Cell Biology
SC Cell Biology
GA 169PD
UT WOS:000320791400001
ER

PT J
AU Allely, CS
AF Allely, C. S.
TI Pain Sensitivity and Observer Perception of Pain in Individuals with
   Autistic Spectrum Disorder
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Review
ID SELF-INJURIOUS-BEHAVIOR; HIGH-FUNCTIONING AUTISM; PERVASIVE
   DEVELOPMENTAL DISORDERS; INTELLECTUALLY DISABLED ADULTS;
   ASPERGER-SYNDROME; YOUNG-CHILDREN; CHALLENGING BEHAVIORS;
   INFANTILE-AUTISM; JUDGING PAIN; PDD-NOS
AB The peer-reviewed literature investigating the relationship between pain expression and perception of pain in individuals with ASD is sparse. The aim of the present systematic PRIMSA review was twofold: first, to see what evidence there is for the widely held belief that individuals with ASD are insensitive to pain or have a high pain threshold in the peer-reviewed literature and, second, to examine whether individuals with ASD react or express pain differently. Fifteen studies investigating pain in individuals with ASD were identified. The case studies all reported pain insensitivity in individuals with ASD. However, the majority of the ten experimental studies reviewed indicate that the idea that individuals with ASD are pain insensitive needs to be challenged. The findings also highlight the strong possibility that not all children with ASD express their physical discomfort in the same way as a neurotypical child would (i.e., cry, moan, seek comfort, etc.) which may lead caregivers and the medical profession to interpret this as pain insensitivity or incorrectly lead them to believe that the child is in no pain. These results have important implications for the assessment and management of pain in children with ASD.
C1 Univ Glasgow, Inst Hlth & Wellbeing, RHSC Yorkhill, Glasgow G3 8SJ, Lanark, Scotland.
RP Allely, CS (reprint author), Univ Glasgow, Inst Hlth & Wellbeing, RHSC Yorkhill, Glasgow G3 8SJ, Lanark, Scotland.
EM clare.allely@glasgow.ac.uk
CR Allely C, 2012, PSYCHOLOGIST, V25, P160
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Avenanti A, 2006, NEUROIMAGE, V32, P316, DOI 10.1016/j.neuroimage.2006.03.010
   Baghdadli A, 2003, J INTELL DISABIL RES, V47, P622, DOI 10.1046/j.1365-2788.2003.00507.x
   Bandstra NF, 2012, CLIN J PAIN, V28, P715, DOI 10.1097/AJP.0b013e318243ecf6
   BARANEK GT, 1994, J AUTISM DEV DISORD, V24, P457, DOI 10.1007/BF02172128
   Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Barrera F. J., 1994, J DEV PHYS DISABIL, V6, P169, DOI 10.1007/BF02579358
   BELTER RW, 1988, J CLIN CHILD PSYCHOL, V17, P329, DOI 10.1207/s15374424jccp1704_6
   Beyer J E, 1990, J Pain Symptom Manage, V5, P350, DOI 10.1016/0885-3924(90)90029-J
   BIERI D, 1990, PAIN, V41, P139, DOI 10.1016/0304-3959(90)90018-9
   BIERSDORFF KK, 1994, AM J MENT RETARD, V98, P619
   Breau LM, 2003, ARCH PEDIAT ADOL MED, V157, P1219, DOI 10.1001/archpedi.157.12.1219
   Breau LM, 2001, CLIN J PAIN, V17, P178, DOI 10.1097/00002508-200106000-00011
   Breau LM, 2011, RES DEV DISABIL, V32, P2829, DOI 10.1016/j.ridd.2011.05.023
   Bursch B, 2004, J PAIN, V5, P290, DOI 10.1016/j.jpain.2004.04.004
   Cascio C, 2008, J AUTISM DEV DISORD, V38, P127, DOI 10.1007/s10803-007-0370-8
   CDC, 2012, MMWR SURVEILL SUMM, V61, P1
   Chambers CT, 1996, CHILD FACIAL CODING
   Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001
   COURCHESNE E, 1989, J AUTISM DEV DISORD, V19, P1, DOI 10.1007/BF02212714
   Daughters H., 2007, J PAIN, V8, pS31, DOI 10.1016/j.jpain.2007.02.124
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   Decety Jean, 2004, Behav Cogn Neurosci Rev, V3, P71, DOI 10.1177/1534582304267187
   DERBYSHIRE SWG, 1994, LANCET, V344, P615, DOI 10.1016/S0140-6736(94)92001-X
   Dunn W, 2001, AM J OCCUP THER, V55, P608
   Dunn W, 2002, AM J OCCUP THER, V56, P97
   Elwin M, 2012, ARCH PSYCHIAT NURS, V26, P420, DOI 10.1016/j.apnu.2011.10.003
   Fernell E, 2010, RES DEV DISABIL, V31, P790, DOI 10.1016/j.ridd.2010.02.003
   Frescka E., 1991, NEUROPEPTIDES PSYCHI, P169
   Furniss F, 2012, J INTELL DISABIL RES, V56, P453, DOI 10.1111/j.1365-2788.2012.01534.x
   Gerland G., 1997, REAL PERSON LIFE OUT
   GILLBERG C, 1985, ARCH GEN PSYCHIAT, V42, P780
   GILLBERG C, 1995, DEV MED CHILD NEUROL, V37, P239
   Gillberg C., 1988, ASPECTS AUTISM BIOL, P31
   Goodenough B, 1997, PAIN, V72, P383, DOI 10.1016/S0304-3959(97)00062-6
   Grandin T., 1995, THINKING PICTURES
   Hadden K. L., 2000, PEDIAT PAIN LETT, V4, P4
   HADJISTAVROPOULOS HD, 1994, J PEDIATR PSYCHOL, V19, P485, DOI 10.1093/jpepsy/19.4.485
   Hicks CL, 2001, PAIN, V93, P173, DOI 10.1016/S0304-3959(01)00314-1
   HUTT SJ, 1965, J PSYCHIAT RES, V3, P181, DOI 10.1016/0022-3956(65)90028-2
   Iarocci G, 2006, J AUTISM DEV DISORD, V36, P77, DOI 10.1007/s10803-005-0044-3
   Inglese M. D., 2008, THESIS U FLORIDA
   Jay SM, 1986, OBSERVATION SCALE BE
   Jensen M. P., 2001, HDB PAIN ASSESSMENT, V2nd, P15
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   KALAT JW, 1978, J AUTISM CHILD SCHIZ, V8, P477, DOI 10.1007/BF01538051
   Kaplan H. I., 1994, KAPLAN SADOCKS SYNOP
   Klintwall L, 2011, RES DEV DISABIL, V32, P795, DOI 10.1016/j.ridd.2010.10.021
   LaChapelle DL, 1999, CLIN J PAIN, V15, P13, DOI 10.1097/00002508-199903000-00004
   Leiberg S, 2006, PROG BRAIN RES, V156, P419, DOI 10.1016/S0079-6123(06)56023-6
   Liberati A, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2700
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   MacLean WE, 2010, J PEDIATR-US, V157, P979, DOI 10.1016/j.jpeds.2010.05.052
   Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
   Matson J, 2008, J INTELLECT DEV DIS, V33, P323, DOI 10.1080/13668250802492600
   Matson JL, 2008, J DEV PHYS DISABIL, V20, P41, DOI 10.1007/s10882-007-9078-0
   MAUK JE, 1993, PEDIATR CLIN N AM, V40, P567
   McGrath PJ, 1998, DEV MED CHILD NEUROL, V40, P340
   MELZACK R, 1975, PAIN, V1, P277, DOI 10.1016/0304-3959(75)90044-5
   MELZACK R, 1965, EXP NEUROL, V13, P163, DOI 10.1016/0014-4886(65)90106-8
   Mercer K. A., 2000, THESIS U CENTRAL LAN
   Messmer RL, 2008, J AUTISM DEV DISORD, V38, P1391, DOI 10.1007/s10803-007-0511-0
   Mieres AC, 2011, PEDIATR PHYS THER, V23, P194, DOI 10.1097/PEP.0b013e318218f35f
   Minio-Paluello I, 2009, BIOL PSYCHIAT, V65, P55, DOI 10.1016/j.biopsych.2008.08.006
   Nader R, 2004, CLIN J PAIN, V20, P88, DOI 10.1097/00002508-200403000-00005
   Nagamitsu S, 1997, J AUTISM DEV DISORD, V27, P155, DOI 10.1023/A:1025839807431
   Nutrition Health Review, 2006, NUTR HLTH REV CONSUM, P5
   ONeill M, 1997, J AUTISM DEV DISORD, V27, P283, DOI 10.1023/A:1025850431170
   Palermo MT, 2006, AUTISM, V10, P353, DOI 10.1177/1362361306064431
   Panksepp J., 1987, NEUROBIOLOGICAL ISSU, P357
   PANKSEPP J, 1979, TRENDS NEUROSCI, V2, P174, DOI 10.1016/0166-2236(79)90071-7
   Peeters T, 1999, AUTISM MED ED ASPECT
   Powers M. D., 1989, CHILDREN AUTISM PARE
   Preston SD, 2002, BEHAV BRAIN SCI, V25, P1
   Prior M., 1986, PSYCHOPATHOLOGICAL D, P156
   Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
   Rojahn J, 2010, J APPL RES INTELLECT, V23, P179, DOI 10.1111/j.1468-3148.2009.00519.x
   Ross-Russell M, 2005, BRIT DENT J, V198, P473, DOI 10.1038/sj.bdj.4812250
   Rutherford MD, 2005, NEUROCASE, V11, P129, DOI 10.1080/13554790590925529
   SANDMAN CA, 1988, SYNAPSE, V2, P193, DOI 10.1002/syn.890020304
   Sandman CA, 1999, MENT RETARD DEV D R, V5, P314, DOI 10.1002/(SICI)1098-2779(1999)5:4<314::AID-MRDD9>3.0.CO;2-G
   Schopler E., 1998, CHILDHOOD AUTISM RAT
   Seid M, 1997, INT J PEDIATR OTORHI, V40, P107, DOI 10.1016/S0165-5876(97)01507-3
   Sher L, 1997, MED HYPOTHESES, V48, P413, DOI 10.1016/S0306-9877(97)90039-6
   SIMONS DJ, 1987, NATURE, V326, P694, DOI 10.1038/326694a0
   Smith KRM, 2010, RES DEV DISABIL, V31, P1062, DOI 10.1016/j.ridd.2010.04.003
   Smith MJL, 2010, NEUROPSYCHOLOGIA, V48, P2777, DOI 10.1016/j.neuropsychologia.2010.03.008
   Stallard P, 2001, ARCH DIS CHILD, V85, P460, DOI 10.1136/adc.85.6.460
   Symons F. J., 2002, SELF INJURIOUS BEHAV
   Temple B., 2012, J DEV DISABILITIES, V18, P73
   Tordjman S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005289
   Tordjman S, 1999, ENCEPHALE, V25, P122
   van Dijk M, 2009, Eur Arch Paediatr Dent, V10, P57
   Wager TD, 2013, NEW ENGL J MED, V368, P1388, DOI 10.1056/NEJMoa1204471
   Wing L., 1996, AUTISTIC SPECTRUM
   Zeltzer LK, 2005, CONQUERING YOUR CHIL
NR 101
TC 2
Z9 3
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 916178
DI 10.1155/2013/916178
PG 20
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 169RQ
UT WOS:000320798200001
ER

PT J
AU Wu, HH
   Levitt, P
AF Wu, Hsiao-Huei
   Levitt, Pat
TI Prenatal Expression of MET Receptor Tyrosine Kinase in the Fetal Mouse
   Dorsal Raphe Nuclei and the Visceral Motor/Sensory Brainstem
SO DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Autism; Motor neurons; Vagal complex; Raphe neurons; Synaptogenesis
ID HEPATOCYTE GROWTH-FACTOR; INTERMEDIATE-FILAMENT PROTEIN; PONTINE
   MICTURITION CENTER; AUTISM SPECTRUM DISORDERS; FACTOR SCATTER FACTOR;
   CEREBROSPINAL-FLUID; BARRINGTONS NUCLEUS; MOLECULAR-CLONING;
   NERVOUS-SYSTEM; GENE MET
AB Signaling via MET receptor tyrosine kinase (MET) has been implicated in a number of neurodevelopmental events, including cell migration, dendritic and axonal development and synaptogenesis. Related to its role in the development of forebrain circuitry, we recently identified a functional promoter variant of the MET gene that is associated with autism spectrum disorder (ASD). The association of the MET promoter variant rs1858830 C allele is significantly enriched in families with a child who has ASD and co-occurring gastrointestinal conditions. The expression of MET in the forebrain had been mapped in detail in the developing mouse and rhesus macaque. However, in mammals, its expression in the developing brainstem has not been studied extensively throughout developmental stages. Brainstem and autonomic circuitry are implicated in ASD pathophysiology and in gastrointestinal dysfunction. To advance our understanding of the neurodevelopmental influences of MET signaling in brainstem circuitry development, we employed in situ hybridization and immunohistochemistry to map the expression of Met and its ligand, Hgf, through prenatal development of the mouse midbrain and hindbrain. Our results reveal a highly selective expression pattern of Met in the brainstem, including a subpopulation of neurons in cranial motor nuclei (nVII, nA and nXII), B6 subgroup of the dorsal raphe, Barrington's nucleus, and a small subset of neurons in the nucleus of solitary tract. In contrast to Met, neither full-length nor known splice variants of Hgf were localized in the prenatal brainstem. RT-PCR revealed Hgf expression in target tissues of Met-expressing brainstem neurons, suggesting that MET in these neurons may be activated by HGF from peripheral sources. Together, these data suggest that MET signaling may influence the development of neurons that are involved in central regulation of gastrointestinal function, tongue movement, swallowing, speech, stress and mood. Copyright (c) 2013 S. Karger AG, Basel
C1 [Wu, Hsiao-Huei; Levitt, Pat] Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Dept Cell & Neurobiol, Los Angeles, CA 90033 USA.
RP Levitt, P (reprint author), USC, Keck Sch Med, Zilkha Neurogenet Inst, 1501 San Pablo St, Los Angeles, CA 90089 USA.
EM plevitt@med.usc.edu
FU Zumberge individual awards; NIMH [MH067842]; Hearing Health Foundation
FX We would like to thank Drs. Alexandre Bonnin and Kathie Eagleson
   (University of Southern California) and Linda Rinaman (University of
   Pittsburgh) for helpful discussions and comments on the manuscript. This
   work was supported by the Hearing Health Foundation (formally Deafness
   Research Foundation) research grant and Zumberge individual awards
   (H.-H. Wu), and NIMH grant MH067842 (P. Levitt).
CR Abounader R, 2005, NEURO-ONCOLOGY, V7, P436, DOI 10.1215/S1152851705000050
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Barclay M, 2007, HISTOCHEM CELL BIOL, V128, P541, DOI 10.1007/s00418-007-0340-4
   Benvenuti S, 2007, J CELL PHYSIOL, V213, P316, DOI 10.1002/jcp.21183
   Birchmeier C, 2003, NAT REV MOL CELL BIO, V4, P915, DOI 10.1038/nrm1261
   Birchmeier C, 1998, TRENDS CELL BIOL, V8, P404, DOI 10.1016/S0962-8924(98)01359-2
   BLADT F, 1995, NATURE, V376, P768, DOI 10.1038/376768a0
   Bradley RM, 2007, ROLE NUCL SOLITARY T
   Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103
   Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180
   Campbell DB, 2009, PEDIATRICS, V123, P1018, DOI 10.1542/peds.2008-0819
   Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27
   Cano G, 2000, J AUTONOM NERV SYST, V79, P117, DOI 10.1016/S0165-1838(99)00101-0
   Caton A, 2000, DEVELOPMENT, V127, P1751
   CHAN AML, 1991, SCIENCE, V254, P1382, DOI 10.1126/science.1720571
   Cioce V, 1996, J BIOL CHEM, V271, P13110
   COOPER CS, 1984, NATURE, V311, P29, DOI 10.1038/311029a0
   COOPER CS, 1984, CANCER RES, V44, P1
   Cordes SP, 2001, NAT REV NEUROSCI, V2, P611, DOI 10.1038/35090039
   DAHLSTROM A, 1964, EXPERIENTIA, V20, P398, DOI 10.1007/BF02147990
   Dauger S, 2003, DEVELOPMENT, V130, P6635, DOI 10.1242/dev.00866
   Ebens A, 1996, NEURON, V17, P1157, DOI 10.1016/S0896-6273(00)80247-0
   Eisen GE, 2009, DEV BIOL, V335, P78, DOI 10.1016/j.ydbio.2009.08.024
   Fischer OM, 2004, J BIOL CHEM, V279, P28970, DOI 10.1074/jbc.M402508200
   Gaddy DF, 2010, DIABETES, V59, P3108, DOI 10.2337/db09-1886
   Gascon E, 2010, J NEUROSCI, V30, P12414, DOI 10.1523/JNEUROSCI.3135-10.2010
   Gentile A, 2008, CANCER METAST REV, V27, P85, DOI 10.1007/s10555-007-9107-6
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237
   Hendricks TJ, 2003, NEURON, V37, P233, DOI 10.1016/S0896-6273(02)01167-4
   HERBERT H, 1990, J COMP NEUROL, V293, P540, DOI 10.1002/cne.902930404
   Jackson PB, 2009, AUTISM RES, V2, P232, DOI 10.1002/aur.87
   JACOBOWITZ DM, 1997, CHEMOARCHITECTONIC A
   Jakubczak JL, 1998, MOL CELL BIOL, V18, P1275
   Judson MC, 2011, CEREB CORTEX, V21, P1613, DOI 10.1093/cercor/bhq223
   Judson MC, 2011, J NEURODEV DISORD, V3, P282, DOI 10.1007/s11689-011-9081-8
   Judson MC, 2009, J COMP NEUROL, V513, P511, DOI 10.1002/cne.21969
   Judson MC, 2010, J COMP NEUROL, V518, P4463, DOI 10.1002/cne.22467
   Kern MA, 2001, CYTOKINE, V14, P170, DOI 10.1006/cyto.2001.0875
   Lamballe F, 2011, J NEUROSCI, V31, P11144, DOI 10.1523/JNEUROSCI.2198-11.2011
   LEVITT P, 1978, ANAT EMBRYOL, V154, P241, DOI 10.1007/BF00345655
   LOKKER NA, 1992, EMBO J, V11, P2503
   Madisen L, 2010, NAT NEUROSCI, V13, P133, DOI 10.1038/nn.2467
   Mayer EA, 2011, NAT REV NEUROSCI, V12, P453, DOI 10.1038/nrn3071
   Mayer EA, 2011, ANNU REV MED, V62, P381, DOI 10.1146/annurev-med-012309-103958
   MIYAZAWA K, 1991, EUR J BIOCHEM, V197, P15, DOI 10.1111/j.1432-1033.1991.tb15876.x
   NAKAMURA T, 1989, NATURE, V342, P440, DOI 10.1038/342440a0
   NAKAMURA T, 1987, FEBS LETT, V224, P311, DOI 10.1016/0014-5793(87)80475-1
   NOTO H, 1989, BRAIN RES, V492, P99, DOI 10.1016/0006-8993(89)90893-7
   NOTO H, 1991, BRAIN RES, V549, P95, DOI 10.1016/0006-8993(91)90604-T
   Pang KH, 2011, PEDIATR SURG INT, V27, P353, DOI 10.1007/s00383-010-2680-8
   Ploeger A, 2010, BIOL PSYCHIAT, V67, P602, DOI 10.1016/j.biopsych.2009.10.010
   Porges SW, 2011, INFANT CHILD DEV, V20, P106, DOI 10.1002/icd.688
   Qiu SF, 2011, J NEUROSCI, V31, P5855, DOI 10.1523/JNEUROSCI.6569-10.2011
   Rose MF, 2009, P NATL ACAD SCI USA, V106, P22462, DOI 10.1073/pnas.0911579106
   Roth DAE, 2012, DEV MED CHILD NEUROL, V54, P23, DOI 10.1111/j.1469-8749.2011.04149.x
   SAWCHENKO PE, 1993, CIBA F SYMP, V172, P5
   SCHMIDT C, 1995, NATURE, V373, P699, DOI 10.1038/373699a0
   Schultz JM, 2009, AM J HUM GENET, V85, P25, DOI 10.1016/j.ajhg.2009.06.003
   Schwall RH, 1996, J CELL BIOL, V133, P709, DOI 10.1083/jcb.133.3.709
   Sieber MA, 2007, J NEUROSCI, V27, P4902, DOI 10.1523/JNEUROSCI.0717-07.2007
   SONNENBERG E, 1993, J CELL BIOL, V123, P223, DOI 10.1083/jcb.123.1.223
   Stenman J, 2003, DEVELOPMENT, V130, P1113, DOI 10.1242/dev.00328
   STOKER M, 1985, J CELL SCI, V77, P209
   STOKER M, 1987, NATURE, V327, P239, DOI 10.1038/327239a0
   SUGAYA K, 1987, NEUROSCI LETT, V80, P197, DOI 10.1016/0304-3940(87)90653-7
   Sved AF, 2002, PHYSIOL BEHAV, V77, P737, DOI 10.1016/S0031-9384(02)00927-7
   TABER E, 1960, J COMP NEUROL, V114, P161, DOI 10.1002/cne.901140205
   Pierce E T, 1973, Prog Brain Res, V40, P53
   TROY CM, 1990, NEUROSCIENCE, V36, P217, DOI 10.1016/0306-4522(90)90364-A
   Trusolino L, 2010, NAT REV MOL CELL BIO, V11, P834, DOI 10.1038/nrm3012
   Tsuboi Y, 2002, ACTA NEUROL SCAND, V106, P99, DOI 10.1034/j.1600-0404.2002.01125.x
   VANBOCKSTAELE EJ, 1993, BRAIN RES, V624, P188, DOI 10.1016/0006-8993(93)90077-Z
   VarelaEchavarria A, 1996, MOL CELL NEUROSCI, V8, P242, DOI 10.1006/mcne.1996.0061
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Wang LW, 2011, J DEV BEHAV PEDIATR, V32, P351, DOI 10.1097/DBP.0b013e31821bd06a
   Waselus M, 2011, J CHEM NEUROANAT, V41, P266, DOI 10.1016/j.jchemneu.2011.05.011
   WEIDNER KM, 1993, J CELL BIOL, V121, P145, DOI 10.1083/jcb.121.1.145
   Wu HH, 2009, NAT NEUROSCI, V12, P1534, DOI 10.1038/nn.2446
   Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145
   Yang L, 2006, DEVELOPMENT, V133, P1575, DOI 10.1242/dev.02322
NR 82
TC 3
Z9 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0378-5866
J9 DEV NEUROSCI-BASEL
JI Dev. Neurosci.
PY 2013
VL 35
IS 1
BP 1
EP 16
DI 10.1159/000346367
PG 16
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 167MW
UT WOS:000320637100001
PM 23548689
ER

PT J
AU Brown, CA
   Kuo, M
   Phillips, L
   Berry, R
   Tan, M
AF Brown, Cary A.
   Kuo, Melissa
   Phillips, Leah
   Berry, Robyn
   Tan, Maria
TI Non-pharmacological sleep interventions for youth with chronic health
   conditions: A critical review of the methodological quality of the
   evidence
SO DISABILITY AND REHABILITATION
LA English
DT Review
DE Children; Critical Review; Intervention; Sleep; Youth
ID RANDOMIZED CONTROLLED-TRIAL; DEFICIT HYPERACTIVITY DISORDER; CHALLENGING
   DAYTIME BEHAVIOR; SEVERE LEARNING-DISABILITIES; PUBLICATION BIAS;
   DEVELOPMENTAL-DISABILITIES; FUNCTIONAL ASSESSMENT; CLINICAL RESEARCH;
   SUBSTANCE-ABUSE; CHRONIC ILLNESS
AB Purpose: Restorative sleep is clearly linked with well-being in youth with chronic health conditions. This review addresses the methodological quality of non-pharmacological sleep intervention (NPSI) research for youth with chronic health conditions. Method: The Guidelines for Critical Review (GCR) and the Effective Public Health Practice Project Quality Assessment Tool (EPHPP) were used in the review. Results: The search yielded 31 behavioural and 10 non-behavioural NPSI for review. Most studies had less than 10 participants. Autism spectrum disorders, attention deficit/hyperactivity disorders, down syndrome, intellectual disabilities, and visual impairments were the conditions that most studies focused upon. The global EPHPP scores indicated most reviewed studies were of weak quality. Only 7 studies were rated as moderate, none were strong. Studies rated as weak quality frequently had recruitment issues; non-blinded participants/parents and/or researchers; and used outcome measures without sound psychometric properties. Conclusions: Little conclusive evidence exists for NPSIs in this population. However, NPSIs are widely used and these preliminary studies demonstrate promising outcomes. There have not been any published reports of negative outcomes that would preclude application of the different NPSIs on a case-by-case basis guided by clinical judgement. These findings support the need for more rigorous, applied research.
C1 [Brown, Cary A.; Kuo, Melissa; Berry, Robyn; Tan, Maria] Univ Alberta, Fac Rehabil Med, Dept Occupat Therapy, Edmonton, AB T6G 2G4, Canada.
   [Phillips, Leah] Concordia Univ, Coll Alberta, Fac Profess Educ, Dept Publ Hlth, Montreal, PQ, Canada.
RP Brown, CA (reprint author), Univ Alberta, Fac Rehabil Med, Dept Occupat Therapy, Edmonton, AB T6G 2G4, Canada.
EM cary.brown@ualberta.ca
CR Acebo C, 1999, SLEEP, V22, P95
   Ancoli-Israel S, 2003, SLEEP, V26, P342
   [Anonymous], DISABILITY REHABILIT
   Armijo-Olivo S, 2012, J EVAL CLIN PRACT, V18, P12, DOI 10.1111/j.1365-2753.2010.01516.x
   Bartlet L., 1998, CLIN CHILD PSYCHOL P, V3, P591, DOI [10.1177/1359104598034010, DOI 10.1177/1359104598034010]
   Bootzin RR, 2005, CLIN PSYCHOL REV, V25, P629, DOI 10.1016/j.cpr.2005.04.007
   Bramble D, 1997, DEV MED CHILD NEUROL, V39, P543
   Brand Serge, 2011, Int J Gen Med, V4, P425, DOI 10.2147/IJGM.S11557
   Britton WB, 2010, SUBST ABUS, V31, P86, DOI 10.1080/08897071003641297
   Bruni O, 1999, CEPHALALGIA, V19, P57
   Byars KC, 2012, PEDIATRICS, V129, pE276, DOI 10.1542/peds.2011-0372
   Canadian Council on Learning (CCL), 2007, HLTH LIT CAN
   Canadian Pediatric Society (CPS), 2003, PAEDIAT CHILD HLTH, V8, P577
   Christodulu KV, 2004, FOCUS AUTISM OTHER D, V19, P130, DOI 10.1177/10883576040190030101
   Colville GA, 1996, DEV MED CHILD NEUROL, V38, P538
   Dahl RE, 2002, J ADOLESCENT HEALTH, V31, P175, DOI 10.1016/S1054-139X(02)00506-2
   DAHL RE, 1991, J PEDIATR PSYCHOL, V16, P229, DOI 10.1093/jpepsy/16.2.229
   Dahl RE, 2007, J FAM PSYCHOL, V21, P1, DOI 10.1037/0893-3200.21.1.1
   Davis CL, 2006, OBESITY, V14, P1985, DOI 10.1038/oby.2006.232
   Deeks J J, 2003, Health Technol Assess, V7, piii
   DICKERSIN K, 1990, JAMA-J AM MED ASSOC, V263, P1385, DOI 10.1001/jama.263.10.1385
   DICKERSIN K, 1987, CONTROL CLIN TRIALS, V8, P343, DOI 10.1016/0197-2456(87)90155-3
   Didden R, 2004, AM J MENT RETARD, V109, P275, DOI 10.1352/0895-8017(2004)109<275:SPIIWS>2.0.CO;2
   Didden R, 1998, J BEHAV THER EXP PSY, V29, P85, DOI 10.1016/S0005-7916(97)00038-4
   Didden R, 2002, J BEHAV THER EXP PSY, V33, P49, DOI 10.1016/S0005-7916(02)00012-5
   Dobbins M, 2009, IMPLEMENT SCI, V4, DOI 10.1186/1748-5908-4-23
   Durand MJ, 1996, J ASSOC PERS SEVERE, V21, P114
   Durand MJ, 2004, J POSIT BEHAV INTERV, V6, P83
   EASTERBROOK PJ, 1991, LANCET, V337, P867, DOI 10.1016/0140-6736(91)90201-Y
   Erickson Jeanne M, 2009, J Pediatr Nurs, V24, P255, DOI 10.1016/j.pedn.2008.03.004
   Escalona A, 2001, J AUTISM DEV DISORD, V31, P513, DOI 10.1023/A:1012273110194
   ESPIE CA, 1993, BEHAV PSYCHOTHER, V21, P51
   Fraser SW, 2001, BRIT MED J, V323, P799, DOI 10.1136/bmj.323.7316.799
   Friedman A, 2008, BEHAV MODIF, V32, P548, DOI 10.1177/0145445507312187
   Gangwisch JE, 2010, SLEEP, V33, P97
   Goodlin-Jones B, 2009, J CHILD PSYCHOL PSYC, V50, P1532, DOI 10.1111/j.1469-7610.2009.02110.x
   Greenhalgh T., 2006, READ PAPER BASICS EV
   Gregory AM, 2009, J SLEEP RES, V18, P422, DOI 10.1111/j.1365-2869.2009.00747.x
   GUILLEMINAULT C, 1993, EUR J PEDIATR, V152, P754, DOI 10.1007/BF01953995
   Halfon N, 2010, JAMA-J AM MED ASSOC, V303, P665, DOI 10.1001/jama.2010.130
   Hart S., 2009, LULLABY MASSAGE RHYM
   Hartman JM, 2002, LARYNGOSCOPE, V112, P23, DOI 10.1097/00005537-200201000-00005
   Hawthorne G, 1997, J ADOLESCENT HEALTH, V20, P384, DOI 10.1016/S1054-139X(96)00181-4
   Haynes PL, 2006, SLEEP, V29, P512
   Heng K, 2006, J CHILD NEUROL, V21, P761, DOI 10.2310/7010.2006.00191
   Hironaka LK, 2008, ARCH DIS CHILD, V93, P428, DOI 10.1136/adc.2007.131516
   HOWLIN P, 1984, BEHAV PSYCHOTHER, V12, P257
   Hysing M, 2009, J PEDIATR PSYCHOL, V34, P665, DOI 10.1093/jpepsy/jsn095
   Ireland JL, 2006, J ADOLESCENT HEALTH, V38, P649, DOI 10.1016/j.jadohealth.2005.05.027
   Jackson N, 2005, HEALTH PROMOT INT, V20, P367, DOI 10.1093/heapro/dai022
   Jadad AR, 1996, CONTROL CLIN TRIALS, V17, P1, DOI 10.1016/0197-2456(95)00134-4
   Jan JE, 2008, PEDIATRICS, V122, P1343, DOI 10.1542/peds.2007-3308
   Johnson EO, 2006, J PSYCHIAT RES, V40, P700, DOI 10.1016/j.jpsychires.2006.07.008
   Katrak Persis, 2004, BMC Med Res Methodol, V4, P22, DOI 10.1186/1471-2288-4-22
   Khan ZU, 2011, CELL MOL LIFE SCI, V68, P1737, DOI 10.1007/s00018-011-0641-6
   La Greca AM, 2001, J PEDIATR PSYCHOL, V26, P279, DOI 10.1093/jpepsy/26.5.279
   Landauer T. K., 1997, HDB HUMAN COMPUTER I, P203
   Law M., 2008, EVIDENCE BASED REHAB
   Lemanek KL, 2001, J PEDIATR PSYCHOL, V26, P253, DOI 10.1093/jpepsy/26.5.253
   Meltzer LJ, 2006, PSYCHIAT CLIN N AM, V29, P1059, DOI 10.1016/j.psc.2006.08.004
   Meltzer LJ, 2010, PEDIATRICS, V125, pE1410, DOI 10.1542/peds.2009-2725
   Mindell JA, 1996, J VISUAL IMPAIR BLIN, V90, P162
   Montgomery P, 2004, SLEEP MED REV, V8, P47, DOI 10.1016/S1087-0792(03)00026-1
   Montgomery P, 2004, ARCH DIS CHILD, V89, P125, DOI 10.1136/adc.2002.017202
   Moon EC, 2011, J PEDIATR PSYCHOL, V36, P47, DOI 10.1093/jpepsy/jsq057
   Mullane Jennifer, 2006, J Atten Disord, V10, P217, DOI 10.1177/1087054706288107
   Newman CJ, 2006, DEV MED CHILD NEUROL, V48, P564, DOI 10.1017/S0012162206001198
   Nutbeam D, 2008, SOC SCI MED, V67, P2072, DOI 10.1016/j.socscimed.2008.09.050
   O'Brien LM, 2003, PEDIATR RES, V54, P237, DOI 10.1203/01.PDR.0000072333.11711.9A
   O'Connell A, 2008, AUST OCCUP THER J, V55, P212, DOI 10.1111/j.1440-1630.2007.00717.x
   OKAWA M, 1987, SLEEP, V10, P101
   Pelsser LM, 2010, EUR J PEDIATR, V169, P1129, DOI 10.1007/s00431-010-1196-5
   Perfect MM, 2010, J CLIN PSYCHOL, V66, P1205, DOI 10.1002/jclp.20732
   Piazza CC, 1998, AM J MENT RETARD, V102, P358
   Piazza CC, 1997, DEV MED CHILD NEUROL, V39, P414
   PIAZZA CC, 1991, J APPL BEHAV ANAL, V24, P129, DOI 10.1901/jaba.1991.24-129
   Portney LG, 2008, FDN CLIN RES APPL PR, V3rd
   Punjabi NM, 2005, J APPL PHYSIOL, V99, P1998, DOI 10.1152/japplphysiol.00695.2005
   Reed HE, 2009, J CHILD NEUROL, V24, P936, DOI 10.1177/0883073808331348
   Roberts RE, 2009, J ADOLESCENCE, V32, P1045, DOI 10.1016/j.adolescence.2009.03.007
   Rodriguez AJ, 2007, CURR NEUROL NEUROSCI, V7, P342, DOI 10.1007/s11910-007-0052-0
   Sanders LM, 2009, ARCH PEDIAT ADOL MED, V163, P131, DOI 10.1001/archpediatrics.2008.539
   Spiegel K, 2008, INT J PEDIATR OBES, V3, P27, DOI 10.1080/17477160802404681
   Storch EA, 2008, J ANXIETY DISORD, V22, P877, DOI 10.1016/j.janxdis.2007.09.003
   Stores G, 1998, CHILD CARE HLTH DEV, V24, P5
   Stores R, 2004, J APPL RES INTELLECT, V17, P61, DOI 10.1111/j.1360-2322.2004.00174.x
   Thackeray EJ, 2002, BEHAV INTERVENT, V17, P211, DOI 10.1002/bin.123
   Thomas B H, 2004, Worldviews Evid Based Nurs, V1, P176, DOI 10.1111/j.1524-475X.2004.04006.x
   Trochim W, 2006, RES METHODS KNOWLEDG
   Vervloed MPJ, 2003, J VISUAL IMPAIR BLIN, V97, P28
   Vriend JL, 2011, J PEDIATR PSYCHOL, V36, P1017, DOI 10.1093/jpepsy/jsr044
   Weiskop S, 2005, DEV MED CHILD NEUROL, V47, P94, DOI 10.1017/S0012162205000186
   Weiskop S, 2001, AUTISM, V5, P209, DOI 10.1177/1362361301005002009
   Wiggs L, 1999, J CHILD PSYCHOL PSYC, V40, P627, DOI 10.1017/S0021963099003881
   Wiggs L, 2001, BRIT J HEALTH PSYCH, V6, P257, DOI 10.1348/135910701169197
   Wiggs L, 1998, J SLEEP RES, V7, P119, DOI 10.1046/j.1365-2869.1998.00107.x
   Wiggs L, 2005, SLEEP, V28, P1437
   Wong MM, 2004, ALCOHOL CLIN EXP RES, V28, P578, DOI 10.1097/01.ALC.0000121651.75952.39
   World Health Organization, 2002, INN CAR CHRON COND B
   World Health Organization, 2011, 10 FACTS AD HLTH
NR 100
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0963-8288
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2013
VL 35
IS 15
BP 1221
EP 1255
DI 10.3109/09638288.2012.723788
PG 35
WC Rehabilitation
SC Rehabilitation
GA 169VM
UT WOS:000320808700001
PM 23050860
ER

PT J
AU Brondino, N
   De Silvestri, A
   Re, S
   Lanati, N
   Thiemann, P
   Verna, A
   Emanuele, E
   Politi, P
AF Brondino, Natascia
   De Silvestri, Annalisa
   Re, Simona
   Lanati, Niccolo
   Thiemann, Pia
   Verna, Anna
   Emanuele, Enzo
   Politi, Pierluigi
TI A Systematic Review and Meta-Analysis of Ginkgo biloba in
   Neuropsychiatric Disorders: From Ancient Tradition to Modern-Day
   Medicine
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID PLACEBO-CONTROLLED TRIAL; EXTRACT EGB 761; DOUBLE-BLIND;
   ALZHEIMERS-DISEASE; RATING-SCALE; CAENORHABDITIS-ELEGANS;
   TARDIVE-DYSKINESIA; CLINICAL-TRIAL; DEMENTIA; SCHIZOPHRENIA
AB Ginkgo biloba (Gb) has demonstrated antioxidant and vasoactive properties as well as clinical benefits in several conditions such as ischemia, epilepsy, and peripheral nerve damage. Additionally, Gb is supposed to act as potential cognitive enhancer in dementia. So far, several trials have been conducted to investigate the potential effectiveness of Gb in neuropsychiatric conditions. However, the results of these studies remain controversial. We conducted a systematic review and a meta-analysis of three randomised controlled trials in patients with schizophrenia and eight randomised controlled trials in patients with dementia. Gb treatment reduced positive symptoms in patients with schizophrenia and improved cognitive function and activities of daily living in patients with dementia. No effect of Gb on negative symptoms in schizophrenic patients was found. The general lack of evidence prevents drawing conclusions regarding Gb effectiveness in other neuropsychiatric conditions (i.e., autism, depression, anxiety, attention-deficit hyperactivity disorder, and addiction). Our data support the use of Gb in patients with dementia and as an adjunctive therapy in schizophrenic patients.
C1 [Brondino, Natascia; Re, Simona; Verna, Anna; Emanuele, Enzo; Politi, Pierluigi] Univ Pavia, Sect Psychiat, Dept Brain & Behav Sci, I-27100 Pavia, Italy.
   [De Silvestri, Annalisa] Fdn IRCCS Policlin San Matteo, Biometr & Stat Unit, I-27100 Pavia, Italy.
   [Lanati, Niccolo] Univ Pavia, Sect Psychiat, Dept Publ Hlth Neurosci Expt & Forens Med, I-27100 Pavia, Italy.
   [Thiemann, Pia] Ruhr Univ Bochum, Inst Psychol, D-44801 Bochum, Germany.
RP Brondino, N (reprint author), Univ Pavia, Sect Psychiat, Dept Brain & Behav Sci, Via Bassi 21, I-27100 Pavia, Italy.
EM natascia.brondino@libero.it
RI De Silvestri, Annalisa/I-6024-2014
OI De Silvestri, Annalisa/0000-0003-3128-8441
CR AMAN MG, 1985, AM J MENT DEF, V89, P485
   Andreasen NC, 1984, SCALE ASSESSMENT POS
   Andreasen NC, 1989, BR J PSYCHIAT S, V7, P49
   Atmaca M, 2005, PSYCHIAT CLIN NEUROS, V59, P652, DOI 10.1111/j.1440-1819.2005.01432.x
   Bastianetto S, 2000, EUR J NEUROSCI, V12, P1882, DOI 10.1046/j.1460-9568.2000.00069.x
   Birks J., 2002, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD003120
   Birks J., 2009, COCHRANE DB SYST REV
   Brane G, 2001, DEMENT GERIATR COGN, V12, P1, DOI 10.1159/000051230
   Conners C. K., 1997, CONNERS RATING SCALE
   Doruk A, 2008, INT CLIN PSYCHOPHARM, V23, P223, DOI 10.1097/YIC.0b013e3282fcff2f
   DuPaul GJ, 1998, ADHD RATING SCALE 4
   Ernst E, 2002, ANN INTERN MED, V136, P42
   Fehske CJ, 2009, PHARMACOL RES, V60, P68, DOI 10.1016/j.phrs.2009.02.012
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50
   Hasanzadeh E, 2012, CHILD PSYCHIAT HUM D, V43, P674, DOI 10.1007/s10578-012-0292-3
   Herrschaft H., 2012, J PSYCHIATR RES, V46, P713
   Hoerr R, 2003, PHARMACOPSYCHIATRY, V36, pS56
   Ihl R, 1999, PHARMACOPSYCHIATRY, V32, P248, DOI 10.1055/s-2007-991102
   Ihl R, 2011, INT J GERIATR PSYCH, V26, P1186, DOI 10.1002/gps.2662
   Kampkotter A, 2007, PHARMACOL RES, V55, P139, DOI 10.1016/j.phrs.2006.11.006
   Kampman K, 2003, ADDICT BEHAV, V28, P437, DOI 10.1016/S0306-4603(02)00226-5
   Kanowski S, 1996, PHARMACOPSYCHIATRY, V29, P47, DOI 10.1055/s-2007-979544
   Kasper S, 2009, FORTSCHR NEUROL PSYC, V77, P494, DOI 10.1055/s-0028-1109504
   Kennedy DO, 2011, ADV NUTR, V2, P32, DOI 10.3945/an.110.000117
   KIM YS, 1993, J CLIN PSYCHOL, V49, P61, DOI 10.1002/1097-4679(199301)49:1<61::AID-JCLP2270490109>3.0.CO;2-B
   KLEIJNEN J, 1992, LANCET, V340, P1136, DOI 10.1016/0140-6736(92)93158-J
   Koch E, 2005, PHYTOMEDICINE, V12, P10, DOI 10.1016/j.phymed.2004.02.002
   Koltermann A, 2007, CELL MOL LIFE SCI, V64, P1715, DOI 10.1007/s00018-007-7085-z
   LeBars PL, 1997, JAMA-J AM MED ASSOC, V278, P1327, DOI 10.1001/jama.278.16.1327
   Maurer K, 1997, J PSYCHIAT RES, V31, P645, DOI 10.1016/S0022-3956(97)00022-8
   Mazza M, 2006, EUR J NEUROL, V13, P981, DOI 10.1111/j.1468-1331.2006.01409.x
   Napryeyenko O, 2007, ARZNEIMITTEL-FORSCH, V57, P4
   Oswald WD, 1995, NURNBERGER ALTERSINV
   OVERALL JE, 1962, PSYCHOL REP, V10, P799
   RAMASSAMY C, 1992, J PHARM PHARMACOL, V44, P943
   Reisberg B, 2001, INT PSYCHOGERIATR, V13, P163, DOI 10.1017/S1041610201007566
   ROSEN WG, 1984, AM J PSYCHIAT, V141, P1356
   Salehi B, 2010, PROG NEURO-PSYCHOPH, V34, P76, DOI 10.1016/j.pnpbp.2009.09.026
   Schneider Lon S., 2005, Current Alzheimer Research, V2, P541, DOI 10.2174/156720505774932287
   SCHOOLER NR, 1982, ARCH GEN PSYCHIAT, V39, P486
   SCHWARTZ GE, 1983, PSYCHOL REP, V53, P479
   Spielberger C., 1970, MANUAL STATE TRAIT A
   van Dongen M, 2003, J CLIN EPIDEMIOL, V56, P367, DOI [10.1016/s0895-4536(03)00003-9, 10.1016/S0895-4356(03)00003-9]
   Wallace BC, 2009, BMC MED RES METHODOL, V9, DOI 10.1186/1471-2288-9-80
   Weinmann S, 2010, BMC GERIATR, V10, DOI 10.1186/1471-2318-10-14
   WHO Collaborating Centre for Drug Statistics Methodology, 2013, ATC DDD IND 2013
   Woelk H, 2007, J PSYCHIATR RES, V41, P472, DOI 10.1016/j.jpsychires.2006.05.004
   Wu YJ, 2006, J NEUROSCI, V26, P13102, DOI 10.1523/JNEUROSCI.3448-06.2006
   Yancheva S, 2009, AGING MENT HEALTH, V13, P183, DOI 10.1080/13607860902749057
   Yoshitake T, 2010, BRIT J PHARMACOL, V159, P659, DOI 10.1111/j.1476-5381.2009.00580.x
   Zhang WF, 2011, J CLIN PSYCHIAT, V72, P615, DOI 10.4088/JCP.09m05125yel
   Zhang XY, 2001, J CLIN PSYCHIAT, V62, P878
NR 52
TC 7
Z9 7
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1741-427X
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
AR 915691
DI 10.1155/2013/915691
PG 11
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 162BF
UT WOS:000320238600001
ER

PT J
AU Caccia, S
AF Caccia, Silvio
TI Safety and Pharmacokinetics of Atypical Antipsychotics in Children and
   Adolescents
SO PEDIATRIC DRUGS
LA English
DT Review
ID CHILDHOOD-ONSET SCHIZOPHRENIA; BIPOLAR I DISORDER; PALIPERIDONE
   EXTENDED-RELEASE; ULTRARAPID CYP1A2 ACTIVITY; DOUBLE-BLIND;
   2ND-GENERATION ANTIPSYCHOTICS; OPEN-LABEL; PSYCHIATRIC-DISORDERS;
   SCHIZOAFFECTIVE DISORDER; SERUM CONCENTRATIONS
AB Pediatric behavioral and affective disorders often require antipsychotic therapy, in combination with psychotherapeutic interventions, for their treatment and stabilization. Although pharmacotherapy can include either typical or atypical antipsychotics, the latter are generally preferred because of their apparently lower risk of adverse effects. Recent controlled trials have demonstrated the efficacy of some of these agents (including aripiprazole, clozapine, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone) in adolescent schizophrenia and children or adolescent bipolar mania, or to treat severe aggression and self-injury in the context of autism in children and adolescents. Although few studies have systematically monitored their short- and, more importantly, long-term safety, current evidence indicates that sedation, hyperprolactinemia, and metabolic abnormalities such as excess weight gain, diabetes, and related cardiovascular effects were clinically relevant adverse effects in young patients, with the individual agents differing in their propensity to induce these effects. When prescribing antipsychotics for children and adolescents, physicians should therefore be aware of the specific adverse effect profiles and patients should be closely monitored for the short- and long-term development of adverse events. In pediatric patients, the starting dose, titration plan, and maintenance dose of antipsychotics must be based on their pharmacokinetics and metabolism, as in adults. Because there are significant individual differences in drug and active metabolite(s) pharmacokinetics and metabolism, which may be further affected by a number of confounding factors (including demographic variables, phenotype and drug interactions), therapeutic drug monitoring may be a valid tool for individualizing dosage, but its interpretation should also take account of changes in pharmacodynamic sensitivity with the development during childhood and adolescence.
C1 Ist Ric Farmacol IRCCS Mario Negri, I-20156 Milan, Italy.
RP Caccia, S (reprint author), Ist Ric Farmacol IRCCS Mario Negri, Via Giuseppe La Masa 19, I-20156 Milan, Italy.
EM silvio.caccia@marionegri.it
CR Aichhorn W, 2007, J CHILD ADOL PSYCHOP, V17, P665, DOI 10.1089/cap.2006.0045
   Alfaro CL, 2002, J CHILD ADOL PSYCHOP, V12, P83, DOI 10.1089/104454602760219126
   Aman MG, 2007, CLIN THER, V29, P1476, DOI 10.1016/j.clinthera.2007.07.026
   Anderson GM, 2007, BIOL PSYCHIAT, V61, P545, DOI 10.1016/j.biopsych.2006.02.032
   [Anonymous], 2009, AR AB PRESCR INF
   [Anonymous], 2010, GEOD ZIPR US PRESCR
   [Anonymous], 2009, INV PAL EXT REL TABL
   [Anonymous], PALIOROSPSZ1001 JOHN
   [Anonymous], 2010, RISP RISP PRESCR INF
   [Anonymous], 2010, INV PAL EXT REL TABL
   [Anonymous], 2011, CLOZ CLOZ PRESCR INF
   Arango C, 2009, EUR CHILD ADOLES PSY, V18, P418, DOI 10.1007/s00787-009-0749-5
   Bachmann CJ, 2008, THER DRUG MONIT, V30, P462, DOI 10.1097/FTD.0b013e318178e18d
   Bachmann CJ, 2008, THER DRUG MONIT, V30, P108, DOI 10.1097/FTD.0b013e3181633429
   Baumann P, 2004, THER DRUG MONIT, V26, P167, DOI 10.1097/00007691-200404000-00014
   Bishop Jeffrey R, 2008, Neuropsychiatr Dis Treat, V4, P55
   Blair J, 2005, J AM ACAD CHILD PSY, V44, P73, DOI 10.1097/01.chi.0000145372.61239.bb
   Caccia S, 2007, CURR DRUG METAB, V8, P612
   Caccia S, 2000, CLIN PHARMACOKINET, V38, P93
   Caccia S, 2011, EXPERT OPIN DRUG MET, V7, P591, DOI 10.1517/17425255.2011.562198
   Caccia S, 2011, EXPERT OPIN DRUG MET, V7, P829, DOI 10.1517/17425255.2011.575061
   Calarge CA, 2009, PHARMACOGENET GENOM, V19, P373, DOI 10.1097/FPC.0b013e328329a60f
   Calarge CA, 2011, J CHILD ADOL PSYCHOP, V21, P163, DOI 10.1089/cap.2010.0038
   Callaghan JT, 1999, CLIN PHARMACOKINET, V37, P177, DOI 10.2165/00003088-199937030-00001
   Castro-Fornieles J, 2008, J CHILD ADOL PSYCHOP, V18, P327, DOI 10.1089/cap.2007.0138
   Cherma MD, 2008, THER DRUG MONIT, V30, P682, DOI 10.1097/FTD.0b013e31818ac8ba
   Cianchetti C, 2011, PSYCHIAT RES, V189, P349, DOI 10.1016/j.psychres.2011.03.020
   Correll CU, 2011, J CLIN PSYCHIAT, V72, P854, DOI 10.4088/JCP.10m05990yel
   Correll CU, 2008, J AM ACAD CHILD PSY, V47, P9, DOI 10.1097/chi.0b013e31815b5cb1
   Correll CU, 2007, J CHILD ADOL PSYCHOP, V17, P647, DOI 10.1089/cap.2006.0117
   Crocq MA, 2007, EUR PSYCHIAT, V22, P453, DOI 10.1016/j.eurpsy.2007.06.004
   Curran MP, 2011, PEDIATR DRUGS, V13, P197, DOI 10.2165/11207230-000000000-00000
   De Hert M, 2011, EUR PSYCHIAT, V26, P144, DOI 10.1016/j.eurpsy.2010.09.011
   DelBello MP, 2009, BIPOLAR DISORD, V11, P483, DOI 10.1111/j.1399-5618.2009.00728.x
   DelBello MP, 2008, 63 ANN M SOC BIOL PS
   DelBello MP, 2008, J CHILD ADOL PSYCHOP, V18, P491, DOI 10.1089/cap.2008.008
   DeVane CL, 2001, CLIN PHARMACOKINET, V40, P509, DOI 10.2165/00003088-200140070-00003
   Eap CB, 2004, J CLIN PSYCHOPHARM, V24, P214, DOI 10.1097/01.jcp.0000116646.91923.2f
   Elbe Dean, 2008, J Can Acad Child Adolesc Psychiatry, V17, P220
   Ely Lilly and Company Ziprexa, 2011, E LILL CO ZIPR OLZA
   Figueroa C, 2009, PROG NEURO-PSYCHOPH, V33, P199, DOI 10.1016/j.pnpbp.2008.09.026
   Findling R, 2003, J CLIN PSYCHIAT, V63, P27
   Findling RL, 2010, J AM ACAD CHILD PSY, V49, P583, DOI 10.1016/j.jaac.2010.03.013
   Findling RL, 2006, J AM ACAD CHILD PSY, V45, P792, DOI 10.1097/01.chi.0000219832.23849.31
   Findling RL, 2008, J CLIN PSYCHOPHARM, V28, P441, DOI 10.1097/JCP.0b013e31817dd520
   Findling RL, 2008, AM J PSYCHIAT, V165, P1432, DOI 10.1176/appi.ajp.2008.07061035
   Findling RL, 2004, J CLIN PSYCHIAT, V65, P30
   Findling RL, 2005, J CLIN PSYCHIAT, V66, P29
   Findling RL, 2008, 55 ANN ME AM AC CHIL
   Findling RL, 2011, J CHILD ADOL PSYCHOP, V21, P345, DOI 10.1089/cap.2010.0102
   Findling RL, 2009, J CHILD ADOL PSYCHOP, V19, P431, DOI 10.1089/cap.2008.0111
   Fleischhaker C, 2008, J NEURAL TRANSM, V115, P1599, DOI 10.1007/s00702-008-0105-9
   Fraguas D, 2011, EUR NEUROPSYCHOPHARM, V21, P621, DOI 10.1016/j.euroneuro.2010.07.002
   Frazier JA, 2003, J CLIN PSYCHOPHARM, V23, P87, DOI 10.1097/00004714-200302000-00012
   Gahr M, 2011, DRUG DES DEV THER, V5, P125, DOI 10.2147/DDDT.S17266
   Gentile S, 2011, PEDIATR DRUGS, V13, P291, DOI 10.2165/11591250-000000000-00000
   Gerbino-Rosen G, 2005, J AM ACAD CHILD PSY, V44, P1024, DOI 10.1097/01.chi.0000171904.23947.54
   Gerlach M, 2007, PHARMACOPSYCHIATRY, V40, P72, DOI 10.1055/s-2007-972573
   Gogtay N, 2008, EXPERT OPIN PHARMACO, V9, P459, DOI 10.1517/14656566.9.3.459 
   Greenaway Masa'il, 2009, J Can Acad Child Adolesc Psychiatry, V18, P250
   Grothe DR, 2000, J CLIN PSYCHOPHARM, V20, P220, DOI 10.1097/00004714-200004000-00015
   Harrison TS, 2004, DRUGS, V64, P1715
   Hehdset M, 2007, EUR J CLIN PHARMACOL, V63, P1147
   Hong IS, 2010, ANN PHARMACOTHER, V44, P1171, DOI 10.1345/aph.1M643
   Jensen JB, 2008, J CHILD ADOL PSYCHOP, V18, P317, DOI 10.1089/cap.2007.0123
   Jensen PS, 2007, EUR CHILD ADOLES PSY, V16, P104, DOI 10.1007/s00787-006-0580-1
   Jones PB, 2006, ARCH GEN PSYCHIAT, V63, P1079, DOI 10.1001/archpsyc.63.10.1079
   Kahn RS, 2008, LANCET, V371, P1085, DOI 10.1016/S0140-6736(08)60486-9
   Kant R, 2004, J CHILD ADOL PSYCHOP, V14, P57, DOI 10.1089/104454604773840490
   Kapetanovic S, 2006, EXPERT OPIN PHARMACO, V7, P1871, DOI 10.1517/14656566.7.14.1871
   Kennedy E, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004027.pub2
   Klampfl K, 2010, PHARMACOPSYCHIATRY, V43, P58, DOI 10.1055/s-0029-1239540
   Knegtering R, 2005, AM J PSYCHIAT, V162, P1010, DOI 10.1176/appi.ajp.162.5.1010
   Kranzler HN, 2006, CHILD ADOL PSYCH CL, V15, P135, DOI 10.1016/j.chc.2005.08.008
   Kryzhanovskaya L, 2009, J AM ACAD CHILD PSY, V48, P60, DOI 10.1097/CHI.0b013e3181900404
   Kubo M, 2007, DRUG METAB PHARMACOK, V22, P358, DOI 10.2133/dmpk.22.358
   Kuehn BM, 2009, JAMA-J AM MED ASSOC, V302, P833, DOI 10.1001/jama.2009.1152
   Kumra S, 2008, BIOL PSYCHIAT, V63, P524, DOI 10.1016/j.biopsych.2007.04.043
   Kumra S, 1996, ARCH GEN PSYCHIAT, V53, P1090
   Labellarte MJ, 2003, J AM ACAD CHILD PSY, V42, P642, DOI 10.1097/01.CH1.0000046860.56865.25
   Lemmon ME, 2011, J CHILD NEUROL, V26, P428, DOI 10.1177/0883073810382143
   Lewis R, 2005, J NEURAL TRANSM-SUPP, V69, P121
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Lincoln J, 2010, J PSYCHIATR PRACT, V16, P103, DOI 10.1097/01.pra.0000369971.64908.dc
   Lobo Evelyn D, 2010, Paediatr Drugs, V12, P201, DOI 10.2165/11532580-000000000-00000
   Maloney AE, 2010, NEUROPSYCH DIS TREAT, V6, P749, DOI 10.2147/NDT.S6614
   Marino J, 2008, PHARMACOTHERAPY, V28, P1283, DOI 10.1592/phco.28.10.1283
   Masi G, 2011, DRUGS, V71, P179, DOI 10.2165/11585350-000000000-00000
   Mauri MC, 2007, CLIN PHARMACOKINET, V46, P359, DOI 10.2165/00003088-200746050-00001
   McConville BJ, 2000, J CLIN PSYCHIAT, V61, P252
   McCormack PL, 2010, CNS DRUGS, V24, P443, DOI 10.2165/11204430-000000000-00000
   McDougle CJ, 2008, J CLIN PSYCHIAT, V69, P15
   McKinney C, 2011, CLIN PSYCHOL REV, V31, P465, DOI 10.1016/j.cpr.2010.11.005
   Mehler-Wex Claudia, 2009, Child Adolesc Psychiatry Ment Health, V3, P14, DOI 10.1186/1753-2000-3-14
   Melkersson KI, 2007, J CLIN PSYCHIAT, V68, P697
   Miceli JJ, 2000, BRIT J CLIN PHARMACO, V49, p5S
   Molden E, 2006, THER DRUG MONIT, V28, P744, DOI 10.1097/01.ftd.0000249944.42859.bf
   Mozes T, 2006, J CHILD ADOL PSYCHOP, V16, P393, DOI 10.1089/cap.2006.16.393
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Nussbaum A, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006369.pub2
   Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
   Ozdemir V, 2001, J CLIN PSYCHOPHARM, V21, P603, DOI 10.1097/00004714-200112000-00011
   Pichini S, 2009, THER DRUG MONIT, V31, P283, DOI 10.1097/FTD.0b013e31819f3328
   Prakash C, 2000, BRIT J CLIN PHARMACO, V49, p35S
   Pringsheim T, 2011, DRUG SAFETY, V34, P651, DOI 10.2165/11592020-000000000-00000
   Remschmidt H, 2000, Paediatr Drugs, V2, P253, DOI 10.2165/00128072-200002040-00002
   Roessner V, 2002, J AM ACAD CHILD ADOL, V41, P921
   Rostami-Hodjegan A, 2004, J CLIN PSYCHOPHARM, V24, P70, DOI 10.1097/01.jcp.0000106221.36344.4d
   Sallee FR, 2000, J AM ACAD CHILD PSY, V39, P292, DOI 10.1097/00004583-200003000-00010
   Sallee FR, 2006, J AM ACAD CHILD PSY, V45, P720, DOI 10.1097/01.chi.0000215347.93902.3e
   Scahil L, 2005, J PSYCHOPHARMACOL, V19, P205, DOI 10.1177/0269881105049042
   Scott Lesley J, 2007, Paediatr Drugs, V9, P343
   Seroquel XR, 2011, SER XR QUET FUM TABL
   Shaw P, 2006, ARCH GEN PSYCHIAT, V63, P721, DOI 10.1001/archpsyc.63.7.721
   Sikich L, 2004, NEUROPSYCHOPHARMACOL, V29, P133, DOI 10.1038/sj.npp.1300327
   Sikich L, 2008, AM J PSYCHIAT, V165, P1420, DOI 10.1176/appi.ajp.2008.08050756
   Singh MK, 2010, DRUGS, V70, P433, DOI 10.2165/11534540-000000000-00000
   Sirot EJ, 2009, J CLIN PSYCHOPHARM, V29, P319, DOI 10.1097/JCP.0b013e3181acc372
   Sparshatt A, 2010, J CLIN PSYCHIAT, V71, P1447, DOI 10.4088/JCP.09r05060gre
   Stigler Kimberly A, 2004, Paediatr Drugs, V6, P33, DOI 10.2165/00148581-200406010-00003
   Theisen FM, 2006, THER DRUG MONIT, V28, P750, DOI 10.1097/01.ftd.0000249950.75462.7f
   Thomas T, 2011, PEDIATR CLIN N AM, V58, P173, DOI 10.1016/j.pcl.2010.10.001
   Thombre AG, 2011, PHARM RES-DORDR, V28, P3159, DOI 10.1007/s11095-011-0505-7
   Thyssen A, 2010, CLIN PHARMACOKINET, V49, P465, DOI 10.2165/11531730-000000000-00000
   Troost PW, 2007, J CLIN PSYCHOPHARM, V27, P52, DOI 10.1097/JCP.0b013e31802e68d5
   Vermeir M, 2008, DRUG METAB DISPOS, V36, P769, DOI 10.1124/dmd.107.018275
   Vitiello B, 2009, EUR NEUROPSYCHOPHARM, V19, P629, DOI 10.1016/j.euroneuro.2009.04.008
   Winter HR, 2008, J CHILD ADOL PSYCHOP, V18, P81, DOI 10.1089/cap.2007.0084
   Zuddas A, 2011, EUR NEUROPSYCHOPHARM, V21, P600, DOI 10.1016/j.euroneuro.2011.04.001
NR 129
TC 7
Z9 7
PU ADIS INT LTD
PI AUCKLAND
PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW
   ZEALAND
SN 1174-5878
J9 PEDIATR DRUGS
JI Pediatr. Drugs
PY 2013
VL 15
IS 3
BP 217
EP 233
DI 10.1007/s40272-013-0024-6
PG 17
WC Pediatrics; Pharmacology & Pharmacy
SC Pediatrics; Pharmacology & Pharmacy
GA 164RB
UT WOS:000320426100006
PM 23588704
ER

PT J
AU Vazquez, FS
   Torres, AS
AF Segado Vazquez, Francisco
   Segado Torres, Alejandra
TI Autism and architecture
SO REVISTA DE PSIQUIATRIA CLINICA
LA English
DT Letter
C1 [Segado Vazquez, Francisco] Polytech Univ Cartagena, Cartagena 30203, Spain.
   [Segado Torres, Alejandra] Univ Complutense Madrid, Fac Med, E-28040 Madrid, Spain.
RP Vazquez, FS (reprint author), Univ Politecn Cartagena, Escuela Arquitectura, Paseo Alfonso 13,50, Cartagena 30203, Spain.
CR Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI 10.1017/CBO9780511526770.002
   Balbuena Rivera F, 2007, REV ASOCIACION ESPAN, V27
   Baron-Cohen, 2009, ENGAGING ARTEFACTS
   Khare R, 2009, ARCHNET IJAR, V3, P45
   Lynch K., 1998, IMAGE CITY
   Mostafa M, 2008, ARCH NET INT J ARCHI, V2, P189
   Norberg-Schulz C, 1980, EXISTENCE SPACE ARCH
   Oyarzun D, 2005, THESIS U CHILE SANTI
   Rutter M, 1984, AUTISM REAPPRAISAL C
   Smith D, 2009, AMJ, V1, P220
   Tamarit J, 1990, PROYECTO ESTRUCTURAC
NR 11
TC 0
Z9 0
PU UNIV SAO PAULO, INST PSIQUIATRIA
PI SAO PAULO
PA RUA OVIDIO PIRES CAMPOS, 785, 1 ANDAR, SAO PAULO, 05403-010, BRAZIL
SN 0101-6083
J9 REV PSIQ CLIN-BRAZIL
JI Rev. Psiquiatr. Clin.
PY 2013
VL 40
IS 2
BP 85
EP 85
PG 1
WC Psychiatry
SC Psychiatry
GA 158WP
UT WOS:000320005000007
ER

PT J
AU Tenenbaum, EJ
   Shah, RJ
   Sobel, DM
   Malle, BF
   Morgan, JL
AF Tenenbaum, Elena J.
   Shah, Rajesh J.
   Sobel, David M.
   Malle, Bertram F.
   Morgan, James L.
TI Increased Focus on the Mouth Among Infants in the First Year of Life: A
   Longitudinal Eye-Tracking Study
SO INFANCY
LA English
DT Article
ID FACE-LIKE STIMULI; DEVELOPMENTAL-CHANGES; NEWBORN-INFANTS; GAZE
   BEHAVIOR; AUTISM; PREFERENCE; PATTERNS; CHILDREN; CONTACT; ADULTS
AB This study examines face-scanning behaviors of infants at 6, 9, and 12months as they watched videos of a woman describing an object in front of her. The videos were created to vary information in the mouth (speaking vs. smiling) and the eyes (gazing into the camera vs. cueing the infant with head turn or gaze direction to an object being described). Infants tended to divide their attention between the eyes and the mouth, looking less at the eyes with age and more at the mouth than the eyes at 9 and 12months. Attention to the mouth was greater on speaking trials than on smiling trials at all three ages, and this difference increased between 6 and 9months. Despite consistent results within subjects, there was considerable variation between subjects. This raises the question of whether a developmental norm of face scanning in infancy ought to be pursued. Rather, these data add to emerging evidence suggesting that individual differences in face scanning might reliably predict aspects of later development.
C1 [Tenenbaum, Elena J.; Shah, Rajesh J.; Sobel, David M.; Malle, Bertram F.; Morgan, James L.] Brown Univ, Dept Cognit Linguist & Psychol Sci, Providence, RI 02912 USA.
RP Tenenbaum, EJ (reprint author), Brown Ctr Study Children Risk, 50 Holden St, Providence, RI 02905 USA.
EM etenenbaum@wihri.org
CR Adamson L., 1995, COMMUNICATION DEV IN
   Chawarska K, 2009, J AUTISM DEV DISORD, V39, P1663, DOI 10.1007/s10803-009-0803-7
   Chawarska K., 2009, INT M AUT RES
   Falck-Ytter T, 2010, DEVELOPMENTAL SCI, V13, P864, DOI 10.1111/j.1467-7687.2009.00942.x
   FANTZ RL, 1963, SCIENCE, V140, P296, DOI 10.1126/science.140.3564.296
   Farroni T, 2006, J EXP CHILD PSYCHOL, V95, P298, DOI 10.1016/j.jecp.2006.08.001
   Frank M. C., INFANCY IN PRESS
   GOREN CC, 1975, PEDIATRICS, V56, P544
   Gredeback G, 2010, DEVELOPMENTAL SCI, V13, P839, DOI 10.1111/j.1467-7687.2009.00945.x
   Gredeback G, 2012, INFANCY, V17, P79, DOI 10.1111/j.1532-7078.2011.00091.x
   HAITH MM, 1977, SCIENCE, V198, P853, DOI 10.1126/science.918670
   Hunnius S, 2004, INFANCY, V6, P231, DOI 10.1207/s15327078in0602_5
   JOHNSON MH, 1991, COGNITION, V40, P1, DOI 10.1016/0010-0277(91)90045-6
   Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946
   Lewkowicz D. J., P NATL ACAD SCI
   Liu SY, 2011, J EXP CHILD PSYCHOL, V108, P180, DOI 10.1016/j.jecp.2010.06.008
   MAURER D, 1976, CHILD DEV, V47, P523, DOI 10.2307/1128813
   Nakano T, 2010, P ROY SOC B-BIOL SCI, V277, P2935, DOI 10.1098/rspb.2010.0587
   Oakes LM, 2012, INFANCY, V17, P1, DOI 10.1111/j.1532-7078.2011.00101.x
   Senju A, 2008, CURR BIOL, V18, P668, DOI 10.1016/j.cub.2008.03.059
   Tenenbaum E., 2012, GAZE FOLLOWING UNPUB
   Turati C, 2005, J EXP CHILD PSYCHOL, V90, P255, DOI 10.1016/j.jecp.2004.11.001
   von Hofsten C, 2009, RES AUTISM SPECT DIS, V3, P556, DOI 10.1016/j.rasd.2008.12.003
   Wheeler A., 2011, PLOS ONE, V6
   Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x
NR 25
TC 8
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1525-0008
J9 INFANCY
JI Infancy
PY 2013
VL 18
IS 4
BP 534
EP 553
DI 10.1111/j.1532-7078.2012.00135.x
PG 20
WC Psychology, Developmental
SC Psychology
GA 157GZ
UT WOS:000319885500005
ER

PT J
AU Mareschal, I
   Calder, AJ
   Dadds, MR
   Clifford, CWG
AF Mareschal, Isabelle
   Calder, Andrew J.
   Dadds, Mark R.
   Clifford, Colin W. G.
TI Gaze categorization under uncertainty: Psychophysics and modeling
SO JOURNAL OF VISION
LA English
DT Article
DE gaze processing; another's gaze; eye contact; modeling
ID EYE-GAZE; PERCEPTION; DIRECTION; LOOKING; AUTISM; ME; ATTENTION;
   CONTACT; SCHIZOPHRENIA; MECHANISMS
AB The accurate perception of another person's gaze direction underlies most social interactions and provides important information about his or her future intentions. As a first step to measuring gaze perception, most experiments determine the range of gaze directions that observers judge as being direct: the cone of direct gaze. This measurement has revealed the flexibility of observers' perception of gaze and provides a useful benchmark against which to test clinical populations with abnormal gaze behavior. Here, we manipulated effective signal strength by adding noise to the eyes of synthetic face stimuli or removing face information. We sought to move beyond a descriptive account of gaze categorization by fitting a model to the data that relies on changing the uncertainty associated with an estimate of gaze direction as a function of the signal strength. This model accounts for all the data and provides useful insight into the visual processes underlying normal gaze perception.
C1 [Mareschal, Isabelle; Clifford, Colin W. G.] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
   [Mareschal, Isabelle; Clifford, Colin W. G.] Univ Sydney, Australian Ctr Excellence Vis Sci, Sydney, NSW 2006, Australia.
   [Mareschal, Isabelle] Queen Mary Univ London, Sch Biol & Chem Sci, London, England.
   [Calder, Andrew J.] MRC Cognit & Brain Sci Unit, Cambridge, England.
   [Dadds, Mark R.] Univ New S Wales, Dept Psychol, Sydney, NSW 2052, Australia.
RP Mareschal, I (reprint author), Queen Mary Univ London, Sch Biol & Chem Sci, London, England.
EM i.mareschal@qmul.ac.uk
FU Australian Research Council [DP120102589]; Australian Research Council
   Future Fellowship; Medical Research Council, UK [MC_US_A060_5PQ50]
FX This work is supported by Australian Research Council Discovery Project
   DP120102589 to C.W.G.C. and A.J.C. C.W.G.C. is supported by an
   Australian Research Council Future Fellowship. A.J.C. is supported by
   the Medical Research Council, UK (grant ref. MC_US_A060_5PQ50).
CR Ando S, 2004, PERCEPTION, V33, P1173, DOI 10.1068/p5297
   ANSTIS SM, 1969, AM J PSYCHOL, V82, P474, DOI 10.2307/1420441
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357
   Calder AJ, 2008, J EXP PSYCHOL GEN, V137, P244, DOI 10.1037/0096-3445.137.2.244
   Campbell R, 2006, DEV PSYCHOPATHOL, V18, P99, DOI 10.1017/S0954579406060068
   CLINE MG, 1967, AM J PSYCHOL, V80, P41, DOI 10.2307/1420539
   Dadds MR, 2011, J CHILD PSYCHOL PSYC, V52, P238, DOI 10.1111/j.1469-7610.2010.02323.x
   Ewbank MP, 2009, J VISION, V9, DOI 10.1167/9.12.16
   Gamer M, 2007, J EXP PSYCHOL HUMAN, V33, P705, DOI 10.1037/0096-1523.33.3.705
   Gamer M, 2011, COGNITION EMOTION, V25, P756, DOI 10.1080/02699931.2010.503117
   GIBSON JJ, 1963, AM J PSYCHOL, V76, P386, DOI 10.2307/1419779
   Hock HS, 2010, SEEING PERCEIVING, V23, P173, DOI 10.1163/187847510X503597
   Huang CB, 2009, J VISION, V9, DOI 10.1167/9.11.24
   Itier RJ, 2009, NEUROSCI BIOBEHAV R, V33, P843, DOI 10.1016/j.neubiorev.2009.02.004
   Jenkins J, 2003, PERCEPTION, V32, P1181, DOI 10.1068/p3398
   Kloth N, 2011, Q J EXP PSYCHOL, V64, P1906, DOI 10.1080/17470218.2011.587254
   Langdon R, 2006, NEUROPSYCHOLOGIA, V44, P417, DOI 10.1016/j.neuropsychologia.2005.05.020
   Langton SRH, 2004, PERCEPT PSYCHOPHYS, V66, P752, DOI 10.3758/BF03194970
   Levi DM, 2009, VISION RES, V49, P2535, DOI 10.1016/j.visres.2009.02.010
   Levi DM, 2008, J VISION, V8, DOI 10.1167/8.4.1
   Lobmaier JS, 2008, EMOTION, V8, P573, DOI 10.1037/1528-3542.8.4.573
   Mareschal I, 2013, CURR BIOL, V23, P717, DOI 10.1016/j.cub.2013.03.030
   MARTIN WW, 1981, J NONVERBAL BEHAV, V5, P155, DOI 10.1007/BF00986132
   NELDER JA, 1965, COMPUT J, V7, P308
   Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030
   Nummenmaa L, 2009, TRENDS COGN SCI, V13, P135, DOI 10.1016/j.tics.2008.12.006
   Ristic J, 2005, COGNITIVE BRAIN RES, V24, P715, DOI 10.1016/j.cogbrainres.2005.02.007
   Senju A, 2008, BRAIN COGNITION, V67, P127, DOI 10.1016/j.bandc.2007.12.001
   Senju A, 2003, COGNITION, V89, pB43, DOI 10.1016/S0010-0277(03)00081-7
   Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9
   Stein T, 2011, J VISION, V11, DOI 10.1167/11.8.5
   Stoyanova RS, 2010, PSYCHOL SCI, V21, P1765, DOI 10.1177/0956797610388812
   Todorovic D, 2006, VISION RES, V46, P3549, DOI 10.1016/j.visres.2006.04.011
   Vida MD, 2012, J EXP CHILD PSYCHOL, V112, P243, DOI 10.1016/j.jecp.2012.02.002
   Webster S, 2008, J AUTISM DEV DISORD, V38, P1184, DOI 10.1007/s10803-008-0539-9
   Winterer G, 2004, TRENDS NEUROSCI, V27, P683, DOI 10.1016/j.tins.2004.08.0042
   Wollaston W. H., 1824, PHILOS T ROY SOC LON, V114, P247, DOI DOI 10.1098/RSTL.1824.0016
NR 38
TC 3
Z9 3
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 1534-7362
J9 J VISION
JI J. Vision
PY 2013
VL 13
IS 5
AR 18
DI 10.1167/13.5.18
PG 10
WC Ophthalmology
SC Ophthalmology
GA 156HR
UT WOS:000319813200017
PM 23608340
ER

PT J
AU Liu, T
   Breslin, CM
AF Liu, Ting
   Breslin, Casey M.
TI The Effect of a Picture Activity Schedule on Performance of the MABC-2
   for Children With Autism Spectrum Disorder
SO RESEARCH QUARTERLY FOR EXERCISE AND SPORT
LA English
DT Article
DE fine motor skills; gross motor skills; visual supports; youth
ID ASPERGERS-SYNDROME; MOTOR
AB Purpose: The purpose of this study was to examine the impact of an assessment protocol utilizing a picture activity schedule on the performance of the Movement Assessment Battery for Children-Second Edition (MABC-2) by children with autism spectrum disorder (ASD). Method: Twenty-five children (ages 3-16 years; 20 boys, 5 girls) performed the MABC-2 under two different protocols (i.e., traditional protocol and picture activity schedule protocol). In the traditional protocol condition, each child received detailed verbal descriptions and demonstrations prior to the motor skill performance. During the picture activity schedule protocol, a picture of each task was presented to the children and the verbal instructions were minimized to emphasize visual supports. MABC-2 percentile scores were analyzed using a within-subjects repeated-measures analysis of variance. Results: All children were delayed or at risk for delay in both fine and gross motor skill performance during the administration of the traditional protocol. However, when the picture activity schedule protocol was utilized, children showed a significantly higher MABC-2 percentile score (12.4) compared with that of the traditional protocol (1.1), F(1, 24) = 24.143, p < .001. Conclusions: The findings indicated that the picture activity schedule protocol may elicit better motor skill performance on the MABC-2 by children with ASD. We suggest researchers and practitioners incorporate a picture activity schedule into the MABC-2 assessment protocol when examining the fine and gross motor performance of children with ASD.
C1 [Liu, Ting] Texas State Univ San Marcos, San Marcos, TX 78666 USA.
   [Breslin, Casey M.] Temple Univ, Philadelphia, PA 19122 USA.
RP Liu, T (reprint author), Texas State Univ San Marcos, Dept Hlth & Human Performance, Coll Educ, 601 Univ Dr, San Marcos, TX 78666 USA.
EM tingliu@txstate.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Baranek G., 2005, HDB AUTISM PERVASIVE, P831
   Bauer P. J., 2000, MONOGRAPHS SOC RES C, V65, DOI [10.1111/1540-5834.00104-112, DOI 10.1111/1540-5834.00104-112]
   Berkeley SL, 2001, ADAPT PHYS ACT Q, V18, P405
   Breslin CM, 2011, ADAPT PHYS ACT Q, V28, P342
   Brown T, 2009, PHYS OCCUP THER PEDI, V29, P86, DOI 10.1080/01942630802574908
   Bryan LC, 2000, J AUTISM DEV DISORD, V30, P553, DOI 10.1023/A:1005687310346
   Centers for Disease Control and Prevention, 2012, NEW DAT AUT SPECTR D
   Charman T, 1997, J AUTISM DEV DISORD, V27, P325, DOI 10.1023/A:1025806616149
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   DEMYER MK, 1981, SCHIZOPHRENIA BULL, V7, P388
   Dooley P., 2001, J POSIT BEHAV INTERV, V3, P57, DOI 10.1177/109830070100300108
   DOWNING JE, 2000, TEACHING EXCEPTIONAL, V33, P62
   Fabbri-Destro M, 2009, EXP BRAIN RES, V192, P521, DOI 10.1007/s00221-008-1578-3
   Grandin T., 1995, THINKING PICTURES OT
   Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054
   Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd
   Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y
   Johnston S., 2003, AUGMENTATIVE ALTERNA, V19, P86, DOI 10.1080/0743461031000112016
   MACDUFF GS, 1993, J APPL BEHAV ANAL, V26, P89, DOI 10.1901/jaba.1993.26-89
   National Research Council, 2001, ED CHILDR AUT
   O'Reilly M, 2005, J AUTISM DEV DISORD, V35, P305, DOI 10.1007/s10803-005-3294-1
   Pan CY, 2009, J AUTISM DEV DISORD, V39, P1694, DOI 10.1007/s10803-009-0813-5
   Provost B, 2007, J AUTISM DEV DISORD, V37, P321, DOI 10.1007/s10803-006-0170-6
   Saigal S, 2005, QUAL LIFE RES, V14, P243, DOI 10.1007/s11136-004-4228-7
   Schneider N, 2010, J POSIT BEHAV INTERV, V12, P149, DOI 10.1177/1098300709334198
   Staples KL, 2010, J AUTISM DEV DISORD, V40, P209, DOI 10.1007/s10803-009-0854-9
   Tissot C., 2003, EARLY CHILD DEV CARE, V173, P425, DOI 10.1080/0300443032000079104
   Ulrich D. A., 2000, TEST GROSS MOTOR DEV
   Vanvuchelen M, 2007, AUTISM, V11, P225, DOI 10.1177/1362361307076846
   Vernazza-Martin S, 2005, J AUTISM DEV DISORD, V35, P91, DOI 10.1007/s10803-004-1037-3
   Welton E., 2004, TEACHING EXCEPTIONAL, V37, P40
NR 32
TC 1
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0270-1367
J9 RES Q EXERCISE SPORT
JI Res. Q. Exerc. Sport
PY 2013
VL 84
IS 2
BP 206
EP 212
DI 10.1080/02701367.2013.784725
PG 7
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
   Sport Sciences
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA 152YS
UT WOS:000319568900009
PM 23930546
ER

PT J
AU Hedvall, A
   Fernell, E
   Holm, A
   Johnels, JA
   Gillberg, C
   Billstedt, E
AF Hedvall, Asa
   Fernell, Elisabeth
   Holm, Anette
   Johnels, Jakob Asberg
   Gillberg, Christopher
   Billstedt, Eva
TI Autism, Processing Speed, and Adaptive Functioning in Preschool Children
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID SPECTRUM DISORDERS; EXECUTIVE FUNCTION; COGNITIVE PROFILES; DYSFUNCTION;
   INDIVIDUALS; POPULATION; ATTENTION; DEFICITS; TASK; ADHD
AB Objectives. To study cognitive test profiles with a focus on processing speed in a representative group of preschool children with autism spectrum disorder (ASD) and relate processing speed to adaptive functioning. Methods. Cognitive assessments were performed in 190 3.6-6.6-year-old children (164 boys and 26 girls) with ASD, using either Griffiths' developmental scales (n = 77) or the Wechsler Preschool and Primary Scale of Intelligence-Third Edition (WPPSI-III) (n = 113). Cognitive data were related to adaptive functioning as measured by Vineland Adaptive Behavior Scales (VABS). Results. Cognitive profiles were characterized by low verbal skills. Low processing speed quotients (PSQs) were found in 66 (78%) of the 85 children who were able to participate in the processing speed subtests. Except for Socialization, all VABS domains (Communication, Motor Skills, Daily Living Skills, and Adaptive Behavior Composite scores) correlated significantly with PSQ. Multiple regression analysis showed that PSQ predicted 38%, 35%, 34%, and 37% of the variance for Communication, Daily Living Skills, Motor Skills, and total Adaptive Composite scores, respectively. Conclusion. Preschool children with ASD had uneven cognitive profiles with low verbal skills, and, relatively, even lower PSQs. Except for Socialization, adaptive functioning was predicted to a considerable degree by PSQ.
C1 [Hedvall, Asa; Fernell, Elisabeth; Johnels, Jakob Asberg; Gillberg, Christopher; Billstedt, Eva] Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, S-41119 Gothenburg, Sweden.
   [Hedvall, Asa; Holm, Anette] Astrid Lindgren Childrens Hosp, Dept Psychol, S-17176 Stockholm, Sweden.
   [Fernell, Elisabeth] Skaraborgss Hosp, Dept Pediat, Ctr Res & Dev, S-54185 Skovde, Sweden.
   [Fernell, Elisabeth] Skaraborgss Hosp, Unit Dev Disorders, S-54185 Skovde, Sweden.
   [Johnels, Jakob Asberg] Univ Gothenburg, Dept Psychol, S-40530 Gothenburg, Sweden.
RP Hedvall, A (reprint author), Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Kungsgatan 12, S-41119 Gothenburg, Sweden.
EM asa.lundholm-hedvall@karolinska.se
FU Gillberg Neuropsychiatry Centre; Wilhelm and Martina Lundgren
   Foundation; Department of Psychology at Karolinska University Hospital
FX The authors are very grateful to all parents and children participating
   in the study and to personnel at the Autism Centre for Young Children.
   The project was financially supported by the Gillberg Neuropsychiatry
   Centre, the Wilhelm and Martina Lundgren Foundation, and the Department
   of Psychology at Karolinska University Hospital.
CR Alin-Akerman B., 1991, GRIFFITHS DEV SCALES
   American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
   Assouline SG, 2012, J AUTISM DEV DISORD, V42, P1781, DOI 10.1007/s10803-011-1403-x
   Beers S. R., 2004, COMPREHENSIVE HDB PS, V1
   Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
   Burack JA, 2002, DEV PSYCHOPATHOL, V14, P225
   Mayes Susan Dickerson, 2006, J Atten Disord, V9, P486, DOI 10.1177/1087054705283616
   Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
   Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022
   Chhabildas N, 2001, J ABNORM CHILD PSYCH, V29, P529, DOI 10.1023/A:1012281226028
   Engman ML, 2008, PEDIATR NEUROL, V38, P398, DOI 10.1016/j.pediatrneurol.2008.02.005
   Fernell E, 2010, RES DEV DISABIL, V31, P790, DOI 10.1016/j.ridd.2010.02.003
   Fernell E, 2011, RES DEV DISABIL, V32, P2092, DOI 10.1016/j.ridd.2011.08.002
   Fountain C, 2012, PEDIATRICS, V129, pE1112, DOI 10.1542/peds.2011-1601
   Frith U, 1996, ACTA PAEDIATR, V85, P63, DOI 10.1111/j.1651-2227.1996.tb14280.x
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Girardot AM, 2012, ENCEPHALE, V38, P488, DOI 10.1016/j.encep.2012.01.013
   HAPPE FGE, 1994, J CHILD PSYCHOL PSYC, V35, P1461, DOI 10.1111/j.1469-7610.1994.tb01287.x
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   HUGHES C, 1994, NEUROPSYCHOLOGIA, V32, P477, DOI 10.1016/0028-3932(94)90092-2
   Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
   KAIL R, 1994, ACTA PSYCHOL, V86, P199, DOI 10.1016/0001-6918(94)90003-5
   Lundervold AJ, 2011, EUR CHILD ADOLES PSY, V20, P121, DOI 10.1007/s00787-010-0153-1
   Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
   Mayes SD, 2007, CHILD NEUROPSYCHOL, V13, P469, DOI 10.1080/09297040601112773
   MCEVOY RE, 1993, J CHILD PSYCHOL PSYC, V34, P563, DOI 10.1111/j.1469-7610.1993.tb01036.x
   Nygren G, 2012, RES DEV DISABIL, V33, P1200, DOI 10.1016/j.ridd.2012.02.018
   Oliveras-Rentas RE, 2012, J AUTISM DEV DISORD, V42, P655, DOI 10.1007/s10803-011-1289-7
   Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110
   Pellicano E, 2007, DEV PSYCHOL, V43, P974, DOI 10.1037/0012-1649.43.4.974
   Perry A, 2009, J AUTISM DEV DISORD, V39, P1066, DOI 10.1007/s10803-009-0704-9
   PREMACK D, 1978, SCIENCE, V202, P532, DOI 10.1126/science.705342
   Russo N, 2007, BRAIN COGNITION, V65, P77, DOI 10.1016/j.bandc.2006.04.007
   Salcedo-Marin MD, 2013, CHILD PSYCHIAT HUM D, V44, P166, DOI 10.1007/s10578-012-0317-y
   Sandberg A. D., 1993, BRIT J PSYCHOL, V84, P3
   SCHATZ J, 1995, J AUTISM DEV DISORD, V25, P51, DOI 10.1007/BF02178167
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Wallace KS, 2010, J CHILD PSYCHOL PSYC, V51, P1300, DOI 10.1111/j.1469-7610.2010.02308.x
   Wechsler D., 2005, WPPSI 3 WECHSLER PRE
NR 41
TC 3
Z9 3
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 158263
DI 10.1155/2013/158263
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 157TZ
UT WOS:000319923400001
ER

PT J
AU Galle, SA
   Courchesne, V
   Mottron, L
   Frasnelli, J
AF Galle, Sara A.
   Courchesne, Valerie
   Mottron, Laurent
   Frasnelli, Johannes
TI Olfaction in the autism spectrum
SO PERCEPTION
LA English
DT Article
DE autism; Asperger syndrome; olfaction; smell; sensory processing
ID PERVASIVE DEVELOPMENTAL DISORDERS; SMELL IDENTIFICATION TEST; ODOR
   RECOGNITION MEMORY; HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME;
   CHILDREN; DISCRIMINATION; PERCEPTION; ADULTS; COLOR
AB The autism spectrum (AS) is characterised by enhanced perception in vision and audition, described by the enhanced perceptual functioning (EPF) model. This model predicts enhanced low-level (discrimination of psychophysical dimensions), and mid- and high-level (pattern detection and identification) perception. The EPF model is here tested for olfaction by investigating olfactory function in autistic and Asperger participants. Experiment I targeted higher-order olfactory processing by assessing olfactory identification in nine Asperger, ten autistic, and eleven typically developed individuals. Experiment 2 focused on low-level olfactory processing; we assessed odour detection thresholds and odour discrimination in five Asperger, five autistic, and five typically developed males. Olfactory identification was impaired in autistic participants relative to control and Asperger participants. Typical performance in low-level olfactory processing suggests that neural mechanisms involved in the perceptual phenotype of AS do not affect structures implicated in olfactory processing. Reduced olfactory identification is limited to autistic participants who displayed speech delay and may be due to a reduced facility to use verbal labels. The apparent absence of enhanced olfactory perception of AS participants distinguishes the olfactory system from the other sensory modalities and might be caused by the absence of an obligatory thalamic relay.
C1 [Galle, Sara A.; Mottron, Laurent] Univ Montreal CETEDUM, Ctr Excellence Troubles Envahissants Dev, Montreal, PQ, Canada.
   [Galle, Sara A.] Univ Amsterdam, Inst Interdisciplinary Studies, Amsterdam, Netherlands.
   [Courchesne, Valerie] Univ Montreal, Montreal, PQ H2V 2S9, Canada.
   [Frasnelli, Johannes] Univ Montreal, Dept Psychol, Ctr Rech Neuropsychol & Cognit CERNEC, Montreal, PQ H2V 2S9, Canada.
RP Frasnelli, J (reprint author), Univ Montreal, Dept Psychol, Ctr Rech Neuropsychol & Cognit CERNEC, 90 Vincent dIndy, Montreal, PQ H2V 2S9, Canada.
EM frasnelli@yahoo.com
FU Canadian Institutes of Health Research [STN-63728]
FX This project was financed by an operating Grant from the Canadian
   Institutes of Health Research to LM (STN-63728). IF is supported by a
   postdoctoral grant from the Canadian Institutes of Health Research.
CR (APA) APA, 2000, DIAGN STAT MAN MENT
   AyabeKanamura S, 1997, PERCEPT MOTOR SKILL, V85, P275
   Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x
   Barbeau E.B., 2012, J ABNORM PSYCHOL, V122, P295
   BEMPORAD JR, 1979, J AUTISM DEV DISORD, V9, P179, DOI 10.1007/BF01531533
   Bennetto L, 2007, BIOL PSYCHIAT, V62, P1015, DOI 10.1016/j.biopsych.2007.04.019
   Bertone A, 2007, J CLIN EXP NEUROPSYC, V29, P467, DOI 10.1080/13803390600770793
   Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561
   Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013
   Bonnel A, 2003, J COGNITIVE NEUROSCI, V15, P226, DOI 10.1162/089892903321208169
   Bonnel A, 2010, NEUROPSYCHOLOGIA, V48, P2465, DOI 10.1016/j.neuropsychologia.2010.04.020
   Braisby N, 1999, J CHILD LANG, V26, P23, DOI 10.1017/S0305000998003638
   Brewer WJ, 2008, RES AUTISM SPECT DIS, V2, P612, DOI 10.1016/j.rasd.2008.01.003
   Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072
   Cascio C, 2008, J AUTISM DEV DISORD, V38, P127, DOI 10.1007/s10803-007-0370-8
   CESARONI L, 1991, J AUTISM DEV DISORD, V21, P303, DOI 10.1007/BF02207327
   Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x
   DOTY RL, 1984, SCIENCE, V226, P1441, DOI 10.1126/science.6505700
   DOTY RL, 1995, NEURODEGENERATION, V4, P93, DOI 10.1006/neur.1995.0011
   Doty RL, 1995, CHEM SENSES, V20, P645, DOI 10.1093/chemse/20.6.645
   DOTY RL, 1984, PHYSIOL BEHAV, V32, P489, DOI 10.1016/0031-9384(84)90269-5
   Dudova I, 2011, EUR CHILD ADOLES PSY, V20, P333, DOI 10.1007/s00787-011-0177-1
   Ehrenstein WH, 1999, MODERN TECHNIQUES NE, P1211
   ENGEN T, 1973, J EXP PSYCHOL, V100, P221, DOI 10.1037/h0035492
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Franklin A, 2008, J AUTISM DEV DISORD, V38, P1837, DOI 10.1007/s10803-008-0574-6
   Franklin A, 2010, DEVELOPMENTAL SCI, V13, P188, DOI 10.1111/j.1467-7687.2009.00869.x
   Frith C, 2003, NOVART FDN SYMP, V251, P181
   Frith C, 2003, NOVART FDN SYMP, V251, P166
   Frith C, 2003, NOVART FDN SYMP, V251, P149
   Giedd JN, 1999, NAT NEUROSCI, V2, P861, DOI 10.1038/13158
   Gomot M, 2008, BRAIN, V131, P2479, DOI 10.1093/brain/awn172
   Gottfried JA, 2005, BRAIN RES REV, V50, P287, DOI 10.1016/j.brainreserv.2005.08.004
   Grandin T., 1986, EMERGENCE LABELLED A
   Halve F, 2006, J AUTISM DEV DISORD, V36, P5
   Hardan AY, 2008, PSYCHIAT RES-NEUROIM, V163, P97, DOI 10.1016/j.pscychresns.2007.12.002
   Heaton P, 2003, J CHILD PSYCHOL PSYC, V44, P543, DOI 10.1111/1469-7610.00143
   Hedner M, 2010, J CLIN EXP NEUROPSYC, V32, P1062, DOI 10.1080/13803391003683070
   Herz RS, 2000, MEM COGNITION, V28, P957, DOI 10.3758/BF03209343
   Herz RS, 1998, ANN NY ACAD SCI, V855, P670, DOI 10.1111/j.1749-6632.1998.tb10643.x
   Hilton CL, 2010, J AUTISM DEV DISORD, V40, P937, DOI 10.1007/s10803-010-0944-8
   Hrdlicka M, 2011, J AUTISM DEV DISORD, V41, P524, DOI 10.1007/s10803-010-1084-x
   Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x
   Jones CRG, 2011, AUTISM RES, V4, P347, DOI 10.1002/aur.209
   Jones CRG, 2009, NEUROPSYCHOLOGIA, V47, P2850, DOI 10.1016/j.neuropsychologia.2009.06.015
   JonesGotman M, 1997, BRAIN, V120, P1845, DOI 10.1093/brain/120.10.1845
   JONESGOTMAN M, 1993, BRAIN COGNITION, V22, P182, DOI 10.1006/brcg.1993.1033
   JONESGOTMAN M, 1988, NEUROPSYCHOLOGIA, V26, P387, DOI 10.1016/0028-3932(88)90093-0
   Jonsson FU, 2005, CHEM SENSES, V30, P353, DOI 10.1093/chemse/bji030
   Kanner L, 1943, NERV CHILD, V2, P217
   Kowalski K, 2006, J EXP CHILD PSYCHOL, V94, P301, DOI 10.1016/j.jecp.2005.12.001
   LARSSON M, 1993, PSYCHOL AGING, V8, P582, DOI 10.1037/0882-7974.8.4.582
   LAWLESS HT, 1975, CHEM SENS FLAV, V1, P331, DOI 10.1093/chemse/1.3.331
   Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7
   LEHRNER JP, 1993, CHEM SENSES, V18, P17, DOI 10.1093/chemse/18.1.17
   LOCKYER L, 1969, BRIT J PSYCHIAT, V115, P865, DOI 10.1192/bjp.115.525.865
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   MAIR R, 1980, J EXP PSYCHOL HUMAN, V6, P445, DOI 10.1037/0096-1523.6.3.445
   May T, 2010, J AUTISM DEV DISORD, V41, P837
   McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59
   Mizuno A, 2006, BRAIN RES, V1104, P160, DOI 10.1016/j.brainres.2006.05.064
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Mottron L, 2009, PHILOS T R SOC B, V364, P1385, DOI 10.1098/rstb.2008.0333
   Nordin S, 2003, J ENVIRON PSYCHOL, V23, P359, DOI 10.1016/S0272-4944(03)00002-1
   Oberg C, 2002, J INT NEUROPSYCH SOC, V8, P691, DOI 10.1017/S1355617702801424
   Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Samson F., 2011, HUM BRAIN MAPP, V33, P1553
   Sandhofer CM, 2001, J EXP PSYCHOL GEN, V130, P600, DOI 10.1037//0096-3445.130.4.600
   Savic I, 2000, NEUROREPORT, V11, P2861, DOI 10.1097/00001756-200009110-00007
   Schipul SE, 2011, FRONTIERS SYSTEMS NE, V5, P1, DOI DOI 10.3389/FNSYS.2011.00010
   Shipley MT, 1996, J NEUROBIOL, V30, P123
   Smythies J, 1997, CONSCIOUS COGN, V6, P455, DOI 10.1006/ccog.1997.0315
   Suzuki Y, 2003, J NEUROPSYCH CLIN N, V15, P105, DOI 10.1176/appi.neuropsych.15.1.105
   Tavassoli T, 2011, J AUTISM DEV DISORD, V42, P905
   Tonoike M, 1998, ANN NY ACAD SCI, V855, P579, DOI 10.1111/j.1749-6632.1998.tb10628.x
   Wang LX, 2007, COGN NEUROPSYCHOL, V24, P550, DOI 10.1080/13546800701417096
   Williams D, 1994, SOMEBODY SOMEWHERE
   Williams D, 1996, AUTISM INSIDE OUT AP
   ZATORRE RJ, 1991, BRAIN, V114, P71
NR 80
TC 2
Z9 2
PU PION LTD
PI LONDON
PA 207 BRONDESBURY PARK, LONDON NW2 5JN, ENGLAND
SN 0301-0066
J9 PERCEPTION
JI Perception
PY 2013
VL 42
IS 3
BP 341
EP 355
DI 10.1068/p7337
PG 15
WC Psychology; Psychology, Experimental
SC Psychology
GA 153WR
UT WOS:000319633700008
PM 23837210
ER

PT J
AU Gill, J
   Liamputtong, P
AF Gill, Jessica
   Liamputtong, Pranee
TI Walk a mile in my shoes: Life as a mother of a child with Asperger's
   Syndrome
SO QUALITATIVE SOCIAL WORK
LA English
DT Article
DE Asperger's Syndrome; Australia women; moral career of motherhood;
   motherhood; paradox of motherhood; qualitative research
ID HIGH-FUNCTIONING AUTISM; FAMILY STRESS; PARENTS; EXPERIENCES;
   SCHOLARSHIP; ADJUSTMENT; STIGMA; TIME
AB In this study, we explore the experiences of mothers with children who have Asperger's Syndrome. A qualitative inquiry was adopted in our study. Fifteen women participated in in-depth interviews, six of whom produced a solicited diary that offered a more in-depth insight into their lives. Thematic analysis was used to examine themes from the transcripts and diary entries. A number of themes emerged from the interview and diary data. First, the women articulated their perceptions of motherhood which included perceptions of an ideal mother, the mother role, the physical and emotional health of mothers and the mask of motherhood. Second, the data revealed the moral career of motherhood which discussed mother blame as a main issue. The findings of this study have implications for health and social care provided to women who are mothers of children with Asperger's Syndrome.
C1 [Gill, Jessica; Liamputtong, Pranee] La Trobe Univ, Bundoora, Vic 3086, Australia.
RP Liamputtong, P (reprint author), La Trobe Univ, Sch Publ Hlth, Bundoora, Vic 3086, Australia.
EM pranee@latrobe.edu.au
CR Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
   Arendell T, 2000, J MARRIAGE FAM, V62, P1192, DOI 10.1111/j.1741-3737.2000.01192.x
   Barnard KE, 1995, HDB PARENTING, V3, P3
   BOUMA R, 1990, J CLIN PSYCHOL, V46, P722, DOI 10.1002/1097-4679(199011)46:6<722::AID-JCLP2270460605>3.0.CO;2-6
   Braun V., 2006, QUALITATIVE RES PSYC, V3, P77, DOI DOI 10.1191/1478088706QP063OA
   Goffman E, 1963, STIGMA NOTES MANAGEM
   GRAY DE, 1993, SOCIOL HEALTH ILL, V15, P102, DOI 10.1111/1467-9566.ep11343802
   Gray DE, 2003, SOC SCI MED, V56, P631, DOI 10.1016/S0277-9536(02)00059-X
   Gray DE, 2006, J INTELL DISABIL RES, V50, P970, DOI 10.1111/j.1365-2788.2006.00933.x
   Gray DE, 2002, SOCIOL HEALTH ILL, V24, P734, DOI 10.1111/1467-9566.00316
   Grbich C, 2007, QUALITATIVE DATA ANA
   Hays S., 1996, CULTURAL CONTRADICTI
   Hesse-Biber S., 2010, PRACTICE QUALITATIVE
   Jokinen E, 2004, QUAL INQ, V10, P339, DOI 10.1177/1077800403257664
   Kingston A., 2007, MOTHERING SPECIAL NE
   Lasser J., 2008, ED PSYCHOL PRACTICE, V24, P335, DOI [10.1080/02667360802488773, DOI 10.1080/02667360802488773]
   Lin CR, 2008, J CLIN NURS, V17, P2733, DOI 10.1111/j.1365-2702.2008.02456.x
   Lupton D, 2000, J SOCIOL, V36, P50, DOI 10.1177/144078330003600104
   Maushart S., 1997, MASK MOTHERHOOD MOTH
   McMahon M., 1995, ENGENDERING MOTHERHO
   Oakley A., 1981, DOING FEMINIST RES, P30
   Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x
   Padgett D.K., 2008, QUALITATIVE METHODS
   Pakenham KI, 2005, AUTISM, V9, P191, DOI 10.1177/1362361305049033
   Patton M. Q, 2002, QUALITATIVE RES EVAL
   Pyles L, 2002, HITCHHIKING ASPERGER
   Read J., 2000, DISABILITY FAMILY SO
   Rich A, 1992, WOMEN BORN MOTHERHOO
   ROSS E, 1995, SIGNS, V20, P397, DOI 10.1086/494980
   Ryan S, 2009, J APPL RES INTELLECT, V22, P43, DOI 10.1111/j.1468-3148.2008.00438.x
   Sanders JL, 1997, CHILD FAM BEHAV THER, V19, P15, DOI 10.1300/J019v19n04_02
   Shuntermann P, 2002, HARVARD REV PSYCHIAT, V10, P16
   Siegel B, 2007, HDB AUTISM PERVASIVE, P748
   Tsai WC, 2008, SOC SCI MED, V67, P1798, DOI 10.1016/j.socscimed.2008.07.015
   Tunali B, 2002, J AUTISM DEV DISORD, V32, P25, DOI 10.1023/A:1017999906420
   Woodgate RL, 2008, QUAL HEALTH RES, V18, P1075, DOI 10.1177/1049732308320112
NR 36
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1473-3250
J9 QUAL SOC WORK
JI Qual. Soc. Work
PD JAN
PY 2013
VL 12
IS 1
BP 41
EP 56
DI 10.1177/1473325011415565
PG 16
WC Social Work
SC Social Work
GA 152VJ
UT WOS:000319559200004
ER

PT J
AU Kovachy, B
   O'Hara, R
   Hawkins, N
   Gershon, A
   Primeau, MM
   Madej, J
   Carrion, V
AF Kovachy, Ben
   O'Hara, Ruth
   Hawkins, Nate
   Gershon, Anda
   Primeau, Michelle M.
   Madej, Jessica
   Carrion, Victor
TI Sleep Disturbance in Pediatric PTSD: Current Findings and Future
   Directions
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Review
DE Pediatric; PTSD; sleep disturbance; subjective measures; objective
   measures
ID POSTTRAUMATIC-STRESS-DISORDER; SEXUAL ASSAULT SURVIVORS;
   COGNITIVE-BEHAVIORAL THERAPY; AUTISM SPECTRUM DISORDERS; SCHOOL-AGED
   CHILDREN; OPEN-LABEL TRIAL; HABITS QUESTIONNAIRE; NIGHTMARE FREQUENCY;
   PRESCHOOL-CHILDREN; IMAGERY REHEARSAL
AB Many studies have provided strong evidence of a fundamental and complex role for sleep disturbances in adult posttraumatic stress disorder (PTSD). Investigations of adult PTSD using subjective and objective measures document sleep architecture abnormalities and high prevalence of sleep disordered breathing, periodic limb movement disorder, nightmares, and insomnia. PTSD treatment methods do appear to significantly improve sleep disturbance, and also studies suggest that treatments for sleep disorders often result in improvements in PTSD symptoms. Further, the most recent evidence suggests sleep abnormalities may precede the development of PTSD. Given the importance of sleep disorders to the onset, course, and treatment of adult PTSD, examination of sleep disturbances far earlier in the life course is imperative. Here we review the literature on what we know about sleep disturbances and disorders in pediatric PTSD. Our review indicates that the extant, empirical data examining sleep disturbance and disorders in pediatric PTSD is limited. Yet, this literature suggests there are significantly higher reports of sleep disturbances and nightmares in children and adolescents exposed to trauma and/or diagnosed with PTSD than in non-trauma-exposed samples. Sleep questionnaires are predominantly employed to assess sleep disorders in pediatric PTSD, with few studies utilizing objective measures. Given the important, complex relationship being uncovered between adult PTSD and sleep, this review calls for further research of sleep in children with PTSD using more specific subjective measures and also objective measures, such as polysomnography and eventually treatment trial studies.
C1 [Kovachy, Ben; O'Hara, Ruth; Hawkins, Nate; Gershon, Anda; Primeau, Michelle M.; Madej, Jessica; Carrion, Victor] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
   [Kovachy, Ben] Harvard Univ, Cambridge, MA USA.
RP O'Hara, R (reprint author), 401 Quarry Rd,C-305, Stanford, CA 94305 USA.
EM roh@stanford.edu
CR Achenbach T. M., 1991, INTEGRATIVE GUIDE 19
   Achenbach T. M., 1983, MANUAL CHILD BEHAV C
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Arbuckle R, 2010, SLEEP MED, V11, P897, DOI 10.1016/j.sleep.2010.03.016
   Arnberg Filip K, 2011, Child Adolesc Psychiatry Ment Health, V5, P8, DOI 10.1186/1753-2000-5-8
   Babson KA, 2010, J ANXIETY DISORD, V24, P1, DOI 10.1016/j.janxdis.2009.08.002
   BELICKI K, 1992, J ABNORM PSYCHOL, V101, P592, DOI 10.1037/0021-843X.101.3.592
   Blader JC, 1997, ARCH PEDIAT ADOL MED, V151, P473
   Brkanac Z, 2003, J AM ACAD CHILD PSY, V42, P384, DOI 10.1097/01.CHI.0000052509.98293.97
   Brown TH, 2011, J TRAUMA STRESS, V24, P575, DOI 10.1002/jts.20680
   Brown TM, 1996, J TRAUMA STRESS, V9, P129, DOI 10.1007/BF02116838
   Bruni O, 2009, SLEEP, V32, pA106
   Bruni O, 1996, J SLEEP RES, V5, P251, DOI 10.1111/j.1365-2869.1996.00251.x
   Buckley A, 2009, SLEEP, V32, pA352
   Buckley AW, 2011, J CHILD ADOL PSYCHOP, V21, P353, DOI 10.1089/cap.2010.0121
   Carrion VG, 2002, J AM ACAD CHILD PSY, V41, P166, DOI 10.1097/00004583-200202000-00010
   Charuvastra A, 2009, CHILD ADOL PSYCH CL, V18, P877, DOI 10.1016/j.chc.2009.04.002
   Chemtob CM, 2008, ARCH PEDIAT ADOL MED, V162, P126, DOI 10.1001/archpediatrics.2007.36
   Chervin Hedger, 2000, SLEEP MED, V1, P21
   CHIMIENTI G, 1989, SOC PSYCH PSYCH EPID, V24, P282, DOI 10.1007/BF01788030
   de la Vega R., 2012, SLEEP MED REV
   De Bellis MD, 2001, J CHILD ADOL PSYCHOP, V11, P311, DOI 10.1089/10445460152595649
   DOLLINGER SJ, 1986, CHILD PSYCHIAT HUM D, V16, P148, DOI 10.1007/BF00706172
   Donnelly CL, 2003, CHILD ADOL PSYCH CL, V12, P251, DOI 10.1016/S1056-4993(02)00102-5
   Forbes EE, 2008, J AM ACAD CHILD PSY, V47, P148, DOI 10.1097/chi.0b013e31815cd9bc
   Fraleigh LA, 2009, J CHILD ADOL PSYCHOP, V19, P475, DOI 10.1089/cap.2009.0002
   Galea S, 2002, J URBAN HEALTH, V79, P340, DOI 10.1093/jurban/79.3.340
   Galovski TE, 2009, J TRAUMA STRESS, V22, P197, DOI 10.1002/jts.20418
   Germain A, 2013, AM J PSYCHIAT, V170, P372, DOI 10.1176/appi.ajp.2012.12040432
   Germain A, 2012, J PSYCHOSOM RES, V72, P89, DOI 10.1016/j.jpsychores.2011.11.010
   Glod CA, 1997, J AM ACAD CHILD PSY, V36, P1236, DOI 10.1097/00004583-199709000-00016
   Goodlin-Jones BL, 2008, J DEV BEHAV PEDIATR, V29, P82, DOI 10.1097/DBP.0b013e318163c39a
   Gregory AM, 2004, J AM ACAD CHILD PSY, V43, P744, DOI 10.1097/01.chi/0000122798.47863.a5
   Gregory AM, 2009, PEDIATRICS, V123, P1171, DOI 10.1542/peds.2008-0825
   Gregory AM, 2009, SLEEP, V32, P189
   Gregory AM, 2012, SLEEP MED REV, V16, P129, DOI 10.1016/j.smrv.2011.03.007
   Gregory AM, 2002, J AM ACAD CHILD PSY, V41, DOI 10.1097/00004583-200208000-00015
   Gregory AM, 2011, J AM ACAD CHILD PSY, V50, P499, DOI 10.1016/j.jaac.2011.02.003
   Horrigan JP, 1996, J AM ACAD CHILD PSY, V35, P975, DOI 10.1097/00004583-199608000-00006
   Hvolby Allan, 2008, Ugeskr Laeger, V170, P448
   KAHN A, 1989, PEDIATRICS, V84, P542
   Kilpatrick DG, 2003, J CONSULT CLIN PSYCH, V71, P692, DOI 10.1037/0022-006X.71.4.692
   Kobayashi I, 2007, PSYCHOPHYSIOLOGY, V44, P660, DOI 10.1111/j.1469-8986.2007.537.x
   Koren D, 2002, AM J PSYCHIAT, V159, P855, DOI 10.1176/appi.ajp.159.5.855
   Kowalik J, 2011, J BEHAV THER EXP PSY, V42, P405, DOI 10.1016/j.jbtep.2011.02.002
   Krakow B, 2000, J TRAUMA STRESS, V13, P589, DOI 10.1023/A:1007854015481
   Krakow Barry, 2002, Sleep Breath, V6, P189
   Krakow B, 2001, AM J PSYCHIAT, V158, P2043, DOI 10.1176/appi.ajp.158.12.2043
   Krakow B, 2002, J ANXIETY DISORD, V16, P175, DOI 10.1016/S0887-6185(02)00093-2
   Krakow B, 2004, J TRAUMA STRESS, V17, P257, DOI 10.1023/B:JOTS.0000029269.29098.67
   Krakow B, 2000, J PSYCHOSOM RES, V49, P291, DOI 10.1016/S0022-3999(00)00147-1
   Krakow B, 2001, J ADOLESCENT HEALTH, V29, P94, DOI 10.1016/S1054-139X(00)00195-6
   Krakow B, 2001, J TRAUMA STRESS, V14, P647, DOI 10.1023/A:1013029819358
   Krakow BJ, 2002, J CLIN PSYCHIAT, V63, P673
   Lamarche LJ, 2007, J CLIN PSYCHIAT, V68, P1257
   Lee Insook, 2004, Taehan Kanho Hakhoe Chi, V34, P636
   Lee KA, 1999, J ADOLESCENT HEALTH, V24, P16, DOI 10.1016/S1054-139X(98)00074-3
   Liu XC, 2000, SLEEP, V23, P1053
   Llabre MM, 2009, PSYCHOSOM MED, V71, P776, DOI 10.1097/PSY.0b013e3181ae6aee
   Luginbuehl M, 2003, SLEEP, V26, pA399
   Luginbuehl M, 2008, SCHOOL PSYCHOL REV, V37, P409
   Maher MJ, 2006, CNS DRUGS, V20, P567, DOI 10.2165/00023210-200620070-00003
   Mellman TA, 2007, J TRAUMA STRESS, V20, P893, DOI 10.1002/jts.20246
   Mellman TA, 2002, AM J PSYCHIAT, V159, P1696, DOI 10.1176/appi.ajp.159.10.1696
   Mindell JA, 2002, CHILD CARE HLTH DEV, V28, P317, DOI 10.1046/j.1365-2214.2002.00274.x
   Montgomery E, 2001, EUR J PUBLIC HEALTH, V11, P18, DOI 10.1093/eurpub/11.1.18
   Montgomery-Downs HE, 2006, PEDIATRICS, V117, P741, DOI 10.1542/peds.2005-1067
   NADER K, 1990, AM J PSYCHIAT, V147, P1526
   Nappi CM, 2012, NEUROPHARMACOLOGY, V62, P576, DOI 10.1016/j.neuropharm.2011.02.029
   Neylan TC, 1998, AM J PSYCHIAT, V155, P929
   Noll JG, 2006, J PEDIATR PSYCHOL, V31, P469, DOI 10.1093/jpepsy/jsj040
   O'Hara R, 2010, AUTISM SPECTRUM COND, P180
   Ohayon MM, 2000, COMPR PSYCHIAT, V41, P469, DOI 10.1053/comp.2000.16568
   Ohayon MM, 2004, SLEEP, V27, P1255
   Owens JA, 2000, SLEEP, V23, P1043
   PYNOOS RS, 1987, ARCH GEN PSYCHIAT, V44, P1057
   Quan SF, 2003, SLEEP MED, V4, P13, DOI 10.1016/S1389-9457(02)00235-6
   Rao V, 2011, J NEUROPSYCH CLIN N, V23, P201, DOI 10.1176/appi.neuropsych.23.2.201
   Raskind MA, 2003, AM J PSYCHIAT, V160, P371, DOI 10.1176/appi.ajp.160.2.371
   SADEH A, 1995, J AM ACAD CHILD PSY, V34, P813, DOI 10.1097/00004583-199506000-00023
   Schoenfeld FB, 2012, J REHABIL RES DEV, V49, P729, DOI 10.1682/JRRD.2011.09.0164
   Schuster MA, 2001, NEW ENGL J MED, V345, P1507, DOI 10.1056/NEJM200111153452024
   Short MA, 2012, SLEEP MED, V13, P378, DOI 10.1016/j.sleep.2011.11.005
   SIMONDS JF, 1984, J DEV BEHAV PEDIATR, V5, P6
   Souders MC, 2009, SLEEP, V32, P1566
   Spoormaker VI, 2008, SLEEP MED REV, V12, P169, DOI 10.1016/j.smrv.2007.08.008
   Spruyt K, 2011, SLEEP MED REV, V15, P19, DOI 10.1016/j.smrv.2010.07.005
   St-Onge M, 2009, BEHAV SLEEP MED, V7, P81, DOI 10.1080/15402000902762360
   Strawn JR, 2011, ANN PHARMACOTHER, V45, P1590, DOI 10.1345/aph.1Q548
   Thabet AA, 2009, INT J SOC PSYCHIATR, V55, P226, DOI 10.1177/0020764008096100
   Thabet AAM, 1999, J CHILD PSYCHOL PSYC, V40, P385, DOI 10.1111/1469-7610.00456
   Thabet AAM, 2004, J CHILD PSYCHOL PSYC, V45, P533, DOI 10.1111/j.1469-7610.2004.00243.x
   Thabet AZ, 2000, CHILD ABUSE NEGLECT, V24, P291, DOI 10.1016/S0145-2134(99)00127-1
   Ulmer CS, 2011, J CLIN SLEEP MED, V7, P57
   van Liempt S, 2012, EUR J PSYCHOTRAUMATO, V3, DOI 10.3402/ejpt.v3i0.19142
   Vignau J, 1997, J ADOLESCENT HEALTH, V21, P343, DOI 10.1016/S1054-139X(97)00109-2
   VILA MT, 2008, AN PEDIATR, V68, P250
   Wamsley EJ, 2012, BIOL PSYCHIAT, V71, P154, DOI 10.1016/j.biopsych.2011.08.008
   Willis TA, 2010, SLEEP MED, V11, P818, DOI 10.1016/j.sleep.2010.05.008
   Wittmann L, 2010, J TRAUMA STRESS, V23, P232, DOI 10.1002/jts.20514
   YANG LL, 1987, J CHILD PSYCHOL PSYC, V28, P167, DOI 10.1111/j.1469-7610.1987.tb00660.x
   Yesavage JA, 2012, AM J GERIAT PSYCHIAT, V20, P199, DOI 10.1097/JGP.0b013e3181e446ea
   Youakim JM, 1998, PSYCHOSOMATICS, V39, P168
   Zayfert C, 2004, J TRAUMA STRESS, V17, P69, DOI 10.1023/B:JOTS.0000014679.31799.e7
NR 104
TC 0
Z9 0
PU AMER ACAD SLEEP MEDICINE
PI WESTCHESTER
PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA
SN 1550-9389
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PY 2013
VL 9
IS 5
BP 503
EP 512
DI 10.5664/jcsm.2678
PG 10
WC Clinical Neurology
SC Neurosciences & Neurology
GA 147WC
UT WOS:000319199100014
ER

PT J
AU Hayashi, T
   Yoshida, T
   Mishina, M
AF Hayashi, Takashi
   Yoshida, Tomoyuki
   Mishina, Masayoshi
TI IL1RAPL1 associated with mental retardation and autism regulates the
   formation and stabilization of glutamatergic synapses of cortical
   neurons through RhoA signaling pathway
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Meeting Abstract
CT 86th Annual Meeting of the Japanese-Pharmacological-Society
CY MAR 21-23, 2013
CL Fukuoka, JAPAN
SP Japanese Pharmacol Soc
C1 [Hayashi, Takashi; Yoshida, Tomoyuki; Mishina, Masayoshi] Univ Tokyo, Grad Sch Med, Dept Mol Neurobiol & Pharmacol, Bunkyo Ku, Tokyo 1130033, Japan.
   [Mishina, Masayoshi] Ritsumeikan Univ, Brain Sci Lab, Kusatsu, Shiga 5258577, Japan.
NR 0
TC 0
Z9 0
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PY 2013
VL 121
SU 1
BP 121P
EP 121P
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 151WL
UT WOS:000319491000404
ER

PT J
AU Takada, Y
   Hirano, M
   Kiyonaka, S
   Mori, Y
AF Takada, Yoshinori
   Hirano, Mitsuru
   Kiyonaka, Shigeki
   Mori, Yasuo
TI Mutation associated with autism modifies RIMS3-mediated modulation of
   voltage-dependent Ca2+ channels
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Meeting Abstract
CT 86th Annual Meeting of the Japanese-Pharmacological-Society
CY MAR 21-23, 2013
CL Fukuoka, JAPAN
SP Japanese Pharmacol Soc
C1 [Takada, Yoshinori; Hirano, Mitsuru; Kiyonaka, Shigeki; Mori, Yasuo] Kyoto Univ, Grad Sch Engn, Dept Synthet Chem & Biol Chem, Nishikyo Ku, Kyoto 6158510, Japan.
   [Kiyonaka, Shigeki; Mori, Yasuo] Kyoto Univ, Dept Technol & Ecol, Nishikyo Ku, Kyoto 6158510, Japan.
NR 0
TC 0
Z9 0
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PY 2013
VL 121
SU 1
BP 173P
EP 173P
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 151WL
UT WOS:000319491000604
ER

PT J
AU Williamson, RL
   Casey, LB
   Robertson, JS
   Buggey, T
AF Williamson, Robert L.
   Casey, Laura B.
   Robertson, Janna Siegel
   Buggey, Tom
TI Video Self-Modeling in Children with Autism: A Pilot Study Validating
   Prerequisite Skills and Extending the Utilization of VSM across Skill
   Sets
SO ASSISTIVE TECHNOLOGY
LA English
DT Article
DE special education; video self-modeling; mobile technology; autism;
   prerequisite skills
ID INTERVENTIONS; STUDENTS; BEHAVIOR; SCHOOL
AB Given the recent interest in the use of video self-modeling (VSM) to provide instruction within iPod apps and other pieces of handheld mobile assistive technologies, investigating appropriate prerequisite skills for effective use of this intervention is particularly timely and relevant. To provide additional information regarding the efficacy of VSM for students with autism and to provide insights into any possible prerequisite skills students may require for such efficacy, the authors investigated the use of VSM in increasing the instances of effective initiations of interpersonal greetings for three students with autism that exhibited different pre-intervention abilities. Results showed that only one of the three participants showed an increase in self-initiated greetings following the viewing of videos edited to show each participant self-modeling a greeting when entering his or her classroom. Due to the differences in initial skill sets between the three children, this finding supports anecdotally observed student prerequisite abilities mentioned in previous studies that may be required to effectively utilize video based teaching methods.
C1 [Williamson, Robert L.; Casey, Laura B.] Univ Memphis, Memphis, TN 38152 USA.
   [Robertson, Janna Siegel] Univ N Carolina, Dept Instruct Technol Fdn & Secondary Educ, Watson Sch Educ, Wilmington, NC 28401 USA.
   [Buggey, Tom] Univ Tennessee, Ctr Child & Family Studies, Chattanooga, TN USA.
RP Williamson, RL (reprint author), Univ Memphis, 424C Ball Hall, Memphis, TN 38152 USA.
EM rwllmsn1@memphis.edu
CR Ayers K., 2005, EDUC TRAIN DEV DISAB, V40, P183
   Ayres Kevin M, 2008, Journal of Special Education Technology, V23
   Bandura A., 1976, SOCIAL LEARNING THEO
   Buggey T, 2007, J POSIT BEHAV INTERV, V9, P151, DOI 10.1177/10983007070090030301
   Buggey T., 2005, FOCUS AUTISM OTHER D, V20, P52, DOI DOI 10.1177/10883576050200010501
   Buggey T., 1999, J POSIT BEHAV INTERV, V1, P205, DOI 10.1177/109830079900100403
   Buggey T, 2009, SEEING IS BELIEVING
   Charlop Marjorie H, 2008, Journal of Special Education Technology, V23
   CREER TL, 1970, BEHAV RES THER, V8, P91, DOI 10.1016/0005-7967(70)90040-9
   Dowrick PW, 1999, APPL PREV PSYCHOL, V8, P23, DOI 10.1016/S0962-1849(99)80009-2
   DOWRICK PW, 1977, J CONSULT CLIN PSYCH, V45, P1156, DOI 10.1037//0022-006X.45.6.1156
   Hitchcock CH, 2004, LEARN DISABILITY Q, V27, P89, DOI 10.2307/1593644
   KAHN JS, 1990, SCHOOL PSYCHOL REV, V19, P196
   MCCURDY BL, 1988, J SCHOOL PSYCHOL, V26, P371, DOI 10.1016/0022-4405(88)90044-1
   McMillan J. H., 2001, RES ED CONCEPTUAL IN, V5th
   Neisworth J. T., 2003, VIDEOTAPED SELF MODE
   Skinner B. F., 1957, VERBAL BEHAV
   Wert BY, 2003, J POSIT BEHAV INTERV, V5, P30, DOI 10.1177/10983007030050010501
   WOLTERSDORF MA, 1992, CHILD FAM BEHAV THER, V14, P53, DOI 10.1300/J019v14n02_04
NR 19
TC 0
Z9 0
PU R E S N A PRESS
PI ARLINGTON
PA 1700 MOORE ST, STE 1540, ARLINGTON, VA 22209-1903 USA
SN 1040-0435
J9 ASSIST TECHNOL
JI Assist. Technol.
PY 2013
VL 25
IS 2
BP 63
EP 71
DI 10.1080/10400435.2012.712604
PG 9
WC Rehabilitation
SC Rehabilitation
GA 144ZE
UT WOS:000318981200001
PM 23923688
ER

PT J
AU Garcia, D
   Anckarsater, H
   Lundstrom, S
AF Garcia, Danilo
   Anckarsater, Henrik
   Lundstrom, Sebastian
TI Self-Directedness and Cooperativeness, Psychosocial Dysfunction and
   Suffering in ESSENCE
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; DEFICIT HYPERACTIVITY DISORDER; WELL-BEING
   THERAPY; PSYCHOBIOLOGICAL MODEL; CHARACTER INVENTORY; A-TAC;
   TEMPERAMENT; PERSONALITY; ADOLESCENTS; CHILDHOOD
AB Background. The acronym ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) highlights that children seeking clinical treatment are often multiply impaired, thus requiring treatment from several specialties. The aim was to map and relate, on a population level, ESSENCE to two salient predictors of health and adaptation to adversities, namely, Self-Directedness and Cooperativeness and also to dysfunction and suffering. Methods. Participants were twins (N = 1892) aged 9 or 12 whose parents were interviewed with the Autism-Tics, ADHD and other Comorbidities inventory (A-TAC), and the Junior Temperament and Character Inventory (J-TCI). The A-TAC was first used to discern four ESSENCE-related screening diagnoses: autism spectrum disorders, attention deficit hyperactivity disorder, learning disabilities, and developmental coordination disorder; second, to quantify dysfunction and suffering in important social areas. Results. ESSENCE symptoms were continuously and categorically associated with deficiency in Self-Directedness and Cooperativeness and higher ratings of dysfunction and suffering. The impact of ESSENCE symptoms on these measures of mental health was found in a milder form in about 16% of all children and in a severe formin about 2%. Conclusion. Therapeutic interventions focusing on Self-Directedness and Cooperativeness might provide a novel method for child psychiatry in its approach to ESSENCE.
C1 [Garcia, Danilo; Anckarsater, Henrik; Lundstrom, Sebastian] Univ Gothenburg, Ctr Eth Law & Mental Hlth CELAM, S-43141 Gothenburg, Sweden.
   [Garcia, Danilo; Anckarsater, Henrik; Lundstrom, Sebastian] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, S-43141 Gothenburg, Sweden.
   [Anckarsater, Henrik] Lund Univ, Dept Clin Sci, S-22100 Lund, Sweden.
   [Lundstrom, Sebastian] Swedish Prison & Probat Serv, R&D Unit, S-43141 Gothenburg, Sweden.
   [Lundstrom, Sebastian] Univ Gothenburg, Inst Neurosci & Physiol, Gillberg Neuropsychiat Ctr, S-40530 Gothenburg, Sweden.
RP Garcia, D (reprint author), Univ Gothenburg, Ctr Eth Law & Mental Hlth CELAM, Wallinsgatan 8, S-43141 Gothenburg, Sweden.
EM danilo.garcia@neuro.gu.se; sebastian.lundstrom@neuro.gu.se
FU Swedish Council for Working Life and Social Research; Swedish Research
   Council, Systembolaget; National Board of Forensic Medicine, Swedish
   prison and Probation Services; Bank of Sweden Tercentenary Foundation
FX The CATSS is supported by the Swedish Council for Working Life and
   Social Research, the Swedish Research Council, Systembolaget, the
   National Board of Forensic Medicine, Swedish prison and Probation
   Services, and the Bank of Sweden Tercentenary Foundation.
CR American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
   Anckarsater H, 2010, INT J LAW PSYCHIAT, V33, P59, DOI 10.1016/j.ijlp.2009.12.001
   Anckarsater H, 2006, AM J PSYCHIAT, V163, P1239, DOI 10.1176/appi.ajp.163.7.1239
   Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
   Andersson-Arnten A.-C., 2012, DEPRESSION RES TREAT, DOI [10.1155/2012/925372, DOI 10.1155/2012/925372]
   Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
   Bernardi S, 2012, PSYCHOL MED, V42, P875, DOI 10.1017/S003329171100153X
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Brandstrom S, 2008, EUR J PSYCHOL ASSESS, V24, P14, DOI 10.1027/1015-5759.24.1.14
   Chawarska K, 2009, J CHILD PSYCHOL PSYC, V50, P1235, DOI 10.1111/j.1469-7610.2009.02101.x
   Cloninger C. R., 1994, TEMPERAMENT CHARACTE
   CLONINGER CR, 1993, ARCH GEN PSYCHIAT, V50, P975
   Cloninger CR, 2011, J AFFECT DISORDERS, V128, P24, DOI 10.1016/j.jad.2010.06.012
   Cloninger CR., 2004, FEELING GOOD SCI WEL
   Cloninger CR, 2006, PSYCHIAT ANN, V36, P156
   Coleman M., 2012, AUTISMS
   Cubo E, 2011, AN PEDIATR, V75, P40, DOI 10.1016/j.anpedi.2011.01.008
   D'Souza Russell F, 2004, Australas Psychiatry, V12, P148, DOI 10.1111/j.1039-8562.2004.02095.x
   Fava GA, 2005, PSYCHOTHER PSYCHOSOM, V74, P26, DOI 10.1159/000082023
   Fava GA, 1998, PSYCHOL MED, V28, P475, DOI 10.1017/S0033291797006363
   Fava GA, 1998, ARCH GEN PSYCHIAT, V55, P816, DOI 10.1001/archpsyc.55.9.816
   Garcia D, 2012, PERS INDIV DIFFER, V53, P1034, DOI 10.1016/j.paid.2012.07.025
   Garcia D, 2012, J HAPPINESS STUD, V13, P931, DOI 10.1007/s10902-011-9300-8
   Garcia D, 2012, J HAPPINESS STUD, V13, P999, DOI 10.1007/s10902-011-9303-5
   Garcia D, 2011, PERS INDIV DIFFER, V50, P1208, DOI 10.1016/j.paid.2011.02.009
   Garcia D., RESPONSIBILITY UNPUB
   Giedd JN, 2008, J ADOLESCENT HEALTH, V42, P335, DOI 10.1016/j.jadohealth.2008.01.007
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Gillberg C., 1995, CLIN CHILD NEUROPSYC
   Hansson SL, 2005, BRIT J PSYCHIAT, V187, P262, DOI 10.1192/bjp.187.3.262
   Josefsson K., 2013, PSYCHIAT RES
   Josefsson K, 2013, DEV PSYCHOPATHOL, V25, P713, DOI 10.1017/S0954579413000126
   Kerekes N, 2011, PSYCHOL REP, V107, P715
   Kerekes N., ADHD AUTISM SP UNPUB
   Larson T., PREDICTIVE PRO UNPUB
   Larson T., TEST RETEST RE UNPUB
   Larson T., 2010, BMC PSYCHIAT, V10
   Larsson H, 2012, J CHILD PSYCHOL PSYC, V53, P73, DOI 10.1111/j.1469-7610.2011.02467.x
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Luby JL, 1999, PSYCHOL REP, V84, P1127, DOI 10.2466/PR0.84.3.1127-1138
   Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
   Lundstrom S, 2011, PSYCHOL MED, V41, P2423, DOI 10.1017/S0033291711000377
   Miller DT, 2009, J MED GENET, V46, P242, DOI 10.1136/jmg.2008.059907
   Miniscalco C, 2006, DEV MED CHILD NEUROL, V48, P361, DOI 10.1017/S0012162206000788
   Nigg JT, 2005, DEV PSYCHOPATHOL, V17, P1129, DOI 10.1017/S0954579405050534
   Nigg JT, 2005, DEV PSYCHOPATHOL, V17, P785, DOI 10.1017/S0954579405050376
   Nima AA, 2012, HEALTH, P802, DOI [10.4236/health.2012.410124, DOI 10.4236/HEALTH.2012.410124]
   Schutz E, 2013, PERS INDIV DIFFER, V54, P841, DOI 10.1016/j.paid.2012.12.020
   Seligman M.E.P, 2002, AUTHENTIC HAPPINESS
   Soderstrom H, 2002, AUTISM, V6, P287, DOI 10.1177/1362361302006003006
   SVRAKIC DM, 1993, ARCH GEN PSYCHIAT, V50, P991
   van Dijk FE, 2011, COMPR PSYCHIAT, V53, P39
NR 52
TC 6
Z9 6
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 416981
DI 10.1155/2013/416981
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 144KA
UT WOS:000318936900001
ER

PT J
AU Heil, KM
   Schaaf, CP
AF Heil, Karsten M.
   Schaaf, Christian P.
TI The Genetics of Autism Spectrum Disorders - A Guide for Clinicians
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Autism spectrum disorders; ASDs; Autism genetics; Rare genetic variants;
   Copy number variants; CNVs; Single-nucleotide polymorphisms arrays;
   SNPs; Chromosome microarrays; Array comparative genomic hybridization;
   aCGH; Incomplete penetrance; Variable expressivity; Oligogenic
   heterozygosity; Unclassified variants; Synaptic plasticity; Genome
   sequencing; Common variant common disease model; CVCV; Rare variant
   common disease model; RVCD; Genetic disorders; Psychiatry
ID COPY-NUMBER VARIATION; RARE DE-NOVO; HIGH-FREQUENCY; MUTATIONS; GENES;
   DELETIONS; MICE; DUPLICATIONS; INDIVIDUALS; VARIANTS
AB Recent advances in genetic testing technology have made chromosome microarray analysis (CMA) a first-tier clinical diagnostic test for Autism Spectrum Disorders (ASDs). Two main types of microarrays are available, single nucleotide polymorphism (SNP) arrays and array comparative genomic hybridization (aCGH), each with its own advantages and disadvantages in ASDs testing. Rare genetic variants, and copy number variants (CNVs) in particular, have been shown to play a major role in ASDs. More than 200 autism susceptibility genes have been identified to date, and complex patterns of inheritance, such as oligogenic heterozygosity, appear to contribute to the etiopathogenesis of ASDs. Incomplete penetrance and variable expressivity represent particular challenges in the interpretation of CMA testing of autistic individuals. This review aims to provide an overview of autism genetics for the practicing physician and gives hands-on advice on how to follow-up on abnormal CMA findings in individuals with neuropsychiatric disorders.
C1 [Heil, Karsten M.] Heidelberg Univ, Fac Med, D-69120 Heidelberg, Germany.
   [Schaaf, Christian P.] Baylor Coll Med, Dept Mol & Human Genet, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA.
RP Schaaf, CP (reprint author), Baylor Coll Med, Dept Mol & Human Genet, Jan & Dan Duncan Neurol Res Inst, 1250 Moursund St,Suite 1350, Houston, TX 77030 USA.
EM Karsten.M.Heil@gmail.com; Schaaf@bcm.edu
FU Doris Duke Clinical Scientist Development Award
FX Dr. Schaaf 's work is generously supported by the Joan and Stanford
   Alexander family and the Ting Tsung and Wei Fong Chao Foundation. Dr.
   Schaaf is the recipient of a Doris Duke Clinical Scientist Development
   Award.
CR Bassett AS, 2011, J PEDIATR-US, V159, P332, DOI 10.1016/j.jpeds.2011.02.039
   Bayani J, 2004, CURR PROTOC CELL BIO, DOI DOI 10.1002/0471143030.CB2204S23
   Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589
   Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003
   Brunetti-Pierri N, 2008, NAT GENET, V40, P1466, DOI 10.1038/ng.279
   Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
   Chao HT, 2007, NEURON, V56, P58, DOI 10.1016/j.neuron.2007.08.018
   Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   El-Fishawy P, 2010, PSYCHIAT CLIN N AM, V33, P83, DOI 10.1016/j.psc.2009.12.002
   Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017
   Foo JN, 2012, NAT REV NEUROL
   Gauthier J, 2011, HUM GENET, V130, P563, DOI 10.1007/s00439-011-0975-z
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389
   Jacquemont ML, 2006, J MED GENET, V43, P843, DOI 10.1136/jmg.2006.043166
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Klein RJ, 2010, CELL, V142, P350, DOI 10.1016/j.cell.2010.07.026
   Klein RJ, 2010, CELL, V142, P353
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Lubitz RJ, 2007, GENET TEST, V11, P276, DOI 10.1089/gte.2007.0012
   Lyon GJ, 2012, GENOME MED, V4, DOI 10.1186/gm359
   Majewski J, 2012, HUM MUTAT, V33, P591, DOI 10.1002/humu.22055
   Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   McClellan J, 2010, CELL, V141, P210, DOI 10.1016/j.cell.2010.03.032
   Mervis CB, 2012, AM J HUM GENET, V90, P1064, DOI 10.1016/j.ajhg.2012.04.012
   Miles JH, 2011, GENET MED, V13, P278, DOI 10.1097/GIM.0b013e3181ff67ba
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   National Center for Biotechnology Information (NCBI), HUM GEN ASS INF GRCH
   National Center for Biotechnology Information (NCBI), NCBI DBSNP BUILD 137
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Santangelo AM, 2007, PLOS GENET, V3, P1813, DOI 10.1371/journal.pgen.0030166
   Sato D, 2012, AM J HUM GENET, V90, P879, DOI 10.1016/j.ajhg.2012.03.017
   Schaaf CP, 2011, LANCET, V377, P555, DOI 10.1016/S0140-6736(11)60201-8
   Schaaf CP, 2011, HUM MOL GENET, V20, P3366, DOI 10.1093/hmg/ddr243
   Schaaf CP, 2012, EUR J HUM GENET
   Schaaf CP, 2011, ANNU REV GENOM HUM G, V12, P25, DOI 10.1146/annurev-genom-092010-110715
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Sebat J, 2009, TRENDS GENET, V25, P528, DOI 10.1016/j.tig.2009.10.004
   Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
   Shinawi M, 2010, J MED GENET, V47, P332, DOI 10.1136/jmg.2009.073015
   SMALLEY SL, 1988, ARCH GEN PSYCHIAT, V45, P953
   Sullivan PF, 2012, ARCH GEN PSYCHIAT, V2, P1
   Vaags AK, 2012, AM J HUM GENET, V90, P133, DOI 10.1016/j.ajhg.2011.11.025
   Wang XM, 2011, HUM MOL GENET, V20, P3093, DOI 10.1093/hmg/ddr212
   Welberg L, 2011, NAT REV NEUROSCI, V12, P429, DOI 10.1038/nrn3083
   Willatt L, 2005, AM J HUM GENET, V77, P154, DOI 10.1086/431653
   Ylisaukko-oja T, 2005, EUR J HUM GENET, V13, P1285, DOI 10.1038/sj.ejhg.5201474
   Zoghbi HY, 2003, SCIENCE, V302, P826, DOI 10.1126/science.1089071
NR 54
TC 9
Z9 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD JAN
PY 2013
VL 15
IS 1
AR 3
DI 10.1007/s11920-012-0334-3
PG 8
WC Psychiatry
SC Psychiatry
GA 141XM
UT WOS:000318759800004
PM 23250815
ER

PT J
AU Carlsson, LH
   Norrelgen, F
   Kjellmer, L
   Westerlund, J
   Gillberg, C
   Fernell, E
AF Carlsson, Lotta Hoglund
   Norrelgen, Fritjof
   Kjellmer, Liselotte
   Westerlund, Joakim
   Gillberg, Christopher
   Fernell, Elisabeth
TI Coexisting Disorders and Problems in Preschool Children with Autism
   Spectrum Disorders
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID CHALLENGING BEHAVIORS; EARLY INTERVENTION; POPULATION; SAMPLE;
   COMORBIDITY; PREVALENCE; TODDLERS; ADULTS
AB Objectives. To analyze cooccurring disorders and problems in a representative group of 198 preschool children with autism spectrum disorders (ASD) who had had interventions at a specialized habilitation center. Methods. Parents and children were seen by a research team. Data were based on parental interviews, pediatric assessments, and tests of the child. Information on autistic symptoms, general cognitive function, speech and language, motor function, epilepsy, vision, hearing, activity level, behavior, and sleep was collected. Results. Three ASD categories were used: (1) autistic disorder (AD), (2) autistic-like condition (ALC) or Asperger syndrome, and (3) one group with autistic symptoms/traits but not entirely all its criteria met for ASD. Children with autism had a mean of 3.2 coexisting disorders or problems, the ALC/Asperger group had a mean of 1.6, and children with autistic traits had a mean of 1.6. The most common disorder/problems in the total group pertained to language problems (78%), intellectual disability (ID) (49%), below average motor function (37%), and severe hyperactivity/ADHD (33%). Conclusions. The results accord with the concept of early symptomatic syndromes eliciting neurodevelopmental clinical examination (ESSENCE), and highlight the need of considering ASD in a broad perspective taking also other cooccurring developmental disorders into account.
C1 [Carlsson, Lotta Hoglund; Norrelgen, Fritjof; Kjellmer, Liselotte; Gillberg, Christopher; Fernell, Elisabeth] Gothenburg Univ, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, S-41119 Gothenburg, Sweden.
   [Carlsson, Lotta Hoglund] Astrid Lindgren Childrens Hosp, Dept Pediat, S-11794 Stockholm, Sweden.
   [Norrelgen, Fritjof; Kjellmer, Liselotte] Karolinska Univ Hosp, Dept Speech & Language Pathol, S-17164 Stockholm, Sweden.
   [Kjellmer, Liselotte] Karolinska Inst, Div Speech & Language Pathol, CLINTEC, S-17177 Stockholm, Sweden.
   [Westerlund, Joakim] Stockholm Univ, Dept Psychol, S-11419 Stockholm, Sweden.
   [Fernell, Elisabeth] Skaraborgs Hosp, Dept Pediat, Unit Dev Disorders, S-54224 Mariestad, Sweden.
RP Carlsson, LH (reprint author), Gothenburg Univ, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Kungsgatan 12, S-41119 Gothenburg, Sweden.
EM charlotte.hoglund-carlsson@karolinska.se
CR Alin-Akerman B., 1980, GRIFFITHS DEV SCALES
   Billstedt E, 2011, AUTISM, V15, P7, DOI 10.1177/1362361309346066
   Boltor PF, 2011, BRIT J PSYCHIAT, V198, P289, DOI 10.1192/bjp.bp.109.076877
   Carlsson H. L., 2010, ACTA PAEDIATR, V99, P1897
   Edwards S., 1997, REYNELL DEV LANGUAGE
   Eriksson MA, 2013, EUR CHILD ADOLES PSY, V22, P23, DOI 10.1007/s00787-012-0312-7
   Fernell E, 2010, RES DEV DISABIL, V31, P790, DOI 10.1016/j.ridd.2010.02.003
   Fernell E, 2011, RES DEV DISABIL, V32, P2092, DOI 10.1016/j.ridd.2011.08.002
   Frazier J. A., 2001, J ATTEN DISORD, V4, P203, DOI DOI 10.1177/108705470100400402
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Hattier MA, 2011, DEV NEUROREHABIL, V14, P221, DOI 10.3109/17518423.2011.573836
   Horovitz M, 2011, DEV NEUROREHABIL, V14, P94, DOI 10.3109/17518423.2010.546825
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Kirk S., 2000, ITPA ILLINOIS TEST P
   Levy SE, 2010, J DEV BEHAV PEDIATR, V31, P267, DOI 10.1097/DBP.0b013e3181d5d03b
   Matson JL, 2011, CNS DRUGS, V25, P597, DOI 10.2165/11591700-000000000-00000
   Miniscalco C, 2006, DEV MED CHILD NEUROL, V48, P361, DOI 10.1017/S0012162206000788
   Montiel C, 2008, CHILD PSYCHIAT HUM D, V39, P311, DOI 10.1007/s10578-007-0090-5
   Nygren G, 2012, J AUTISM DEV DISORD, V42, P1491, DOI 10.1007/s10803-011-1391-x
   Nygren G, 2012, RES DEV DISABIL, V33, P1200, DOI 10.1016/j.ridd.2012.02.018
   O'Brien G, 2004, AUTISM, V8, P125, DOI 10.1177/1362361304042718
   Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
   Rydberg S., 1974, SPIQ SNABBT PERFORMA
   Salameh E. K., 2003, LANGUAGE IMPAIRMENT
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Sivertsen B, 2012, AUTISM, V16, P139, DOI 10.1177/1362361311404255
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
NR 28
TC 3
Z9 3
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 213979
DI 10.1155/2013/213979
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 141MU
UT WOS:000318730100001
ER

PT J
AU Elamin, I
   Edwards, MJ
   Martino, D
AF Elamin, Ishraga
   Edwards, Mark J.
   Martino, Davide
TI Immune dysfunction in Tourette syndrome
SO BEHAVIOURAL NEUROLOGY
LA English
DT Article
DE Tourette syndrome; immunity; T cells; antibodies; neuroinflammation;
   allergy
ID OBSESSIVE-COMPULSIVE DISORDER; NEUROPSYCHIATRIC DISORDERS; TIC DISORDER;
   STREPTOCOCCAL INFECTIONS; DIFFERENTIATE PANDAS; SERUM AUTOANTIBODIES;
   GLYCOLYTIC-ENZYMES; NEURONAL SURFACE; SYDENHAMS CHOREA; PYRUVATE-KINASE
AB The association between immunity and neurodevelopmental disorders has been extensively investigated in autism, suggesting a potential involvement of both cellular and humoral immunity in the establishment of synaptic connectivity modulation during development. A similar link has been proposed also for Tourette syndrome (TS), a complex, multifactorial disorder, in which the interplay between genetic, environmental, hormonal and immunological factors might be relevant. Lymphocyte subpopulation analysis in TS suggests a possible systemic activation of several T- and B-cell subtypes, whereas the observed decreased numbers of T regulatory lymphocytes might predispose to autoimmunity. Genes related to both cell- and antibody-mediated immune responses may be over-expressed at specific ages in youngsters with TS. Data from cytokine measurements and transcriptomics profiles in TS patients are coherent with the systemic immune activation detected by studies on lymphocyte subpopulations. Moreover, TS patients have exhibited IgG3 and IgA dysgammaglobulinemia, which might predispose to recurrent infections and autoimmunity. To date, the association between TS and autoantibodies has not been demonstrated. Interestingly, however, there is a higher degree of maternal family history of autoimmune diseases among TS patients. Finally, TS patients could be prone to allergic illnesses (asthma, atopic dermatitis, rhinitis, conjunctivitis), but more work is needed in this area.
C1 [Elamin, Ishraga; Edwards, Mark J.] UCL, Inst Neurol, Sobell Dept Motor Neurosci, London, England.
   [Martino, Davide] Queen Mary Univ London, Barts & London Sch Med & Dent, Ctr Neurosci & Trauma, London E1 2AT, England.
   [Martino, Davide] South London NHS Trust, Queen Elizabeth Hosp Woolwich, London, England.
RP Martino, D (reprint author), Queen Mary Univ London, Neurosci & Trauma Ctr, Blizard Inst, 4 Newark St, London E1 2AT, England.
EM d.martino@qmul.ac.uk
CR Antonelli F, 2011, NEUROL SCI, V32, P191, DOI 10.1007/s10072-010-0410-6
   Archelos JJ, 2000, TRENDS NEUROSCI, V23, P317, DOI 10.1016/S0166-2236(00)01575-7
   Bombaci M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006332
   Bos-Veneman NGP, 2010, PROG NEURO-PSYCHOPH, V34, P1390, DOI 10.1016/j.pnpbp.2010.06.028
   Bos-Veneman NGP, 2011, BRAIN BEHAV IMMUN, V25, P532, DOI 10.1016/j.bbi.2010.12.003
   Boulanger LM, 2009, NEURON, V64, P93, DOI 10.1016/j.neuron.2009.09.001
   Brilot F, 2011, NEUROLOGY, V76, P1508, DOI 10.1212/WNL.0b013e3182181090
   Brimberg L, 2012, NEUROPSYCHOPHARMACOL, V37, P2076, DOI 10.1038/npp.2012.56
   CAINE ED, 1985, J NEUROL SCI, V69, P201, DOI 10.1016/0022-510X(85)90133-9
   Chang YT, 2011, J DEV BEHAV PEDIATR, V32, P98, DOI 10.1097/DBP.0b013e318208f561
   Chen SK, 2010, CELL, V141, P775, DOI 10.1016/j.cell.2010.03.055
   Cools Nathalie, 2007, Clin Dev Immunol, V2007, P89195, DOI 10.1155/2007/89195
   Dale RC, 2006, J NEUROIMMUNOL, V172, P187, DOI 10.1016/j.jneuroim.2005.10.014
   Dhar-Chowdhury P, 2005, J BIOL CHEM, V280, P38464, DOI 10.1074/jbc.M508744200
   Ferrari M, 2008, J PSYCHIATR RES, V43, P24, DOI 10.1016/j.jpsychires.2008.01.014
   Gabbay V, 2009, PROG NEURO-PSYCHOPH, V33, P967, DOI 10.1016/j.pnpbp.2009.05.001
   Garay Paula A, 2010, Front Synaptic Neurosci, V2, P136, DOI 10.3389/fnsyn.2010.00136
   Goines P, 2010, CURR OPIN NEUROL, V23, P111, DOI 10.1097/WCO.0b013e3283373514
   Graeber MB, 2010, SCIENCE, V330, P783, DOI 10.1126/science.1190929
   Hansen CR, 1997, J AM ACAD CHILD PSY, V36, P1648, DOI 10.1097/00004583-199712000-00006
   Ho CS, 1999, J FORMOS MED ASSOC, V98, P492
   Hoekstra PJ, 2004, AM J PSYCHIAT, V161, P1501, DOI 10.1176/appi.ajp.161.8.1501-a
   Hoekstra PJ, 2007, EUR CHILD ADOLES PSY, V16, P71, DOI 10.1007/s00787-007-1009-1
   Hoekstra PJ, 2004, J CLIN PSYCHIAT, V65, P537
   Hoffman KL, 2004, J NEUROSCI, V24, P1780, DOI 10.1523/JNEUROSCI.0887-03.2004
   Hong JJ, 2004, J NEUROL SCI, p[225, 57]
   Kansy JW, 2006, J NEUROIMMUNOL, V181, P165, DOI 10.1016/j.jneuroim.2006.08.007
   Kawikova I, 2010, BIOL PSYCHIAT, V67, P679, DOI 10.1016/j.biopsych.2009.09.034
   Kawikova I, 2007, BIOL PSYCHIAT, V61, P273, DOI 10.1016/j.biopsych.2006.06.012
   Kirvan CA, 2006, J NEUROIMMUNOL, V179, P173, DOI 10.1016/j.jneuroim.2006.06.017
   Kirvan CA, 2007, J IMMUNOL, V178, P7412
   Lawrence DMP, 2006, GLIA, V53, P81, DOI 10.1002/glia.20261
   Leckman JF, 2005, BIOL PSYCHIAT, V57, P667, DOI 10.1016/j.biopsych.2004.12.004
   Lit L, 2008, J PSYCHIATR RES, V43, P319, DOI 10.1016/j.jpsychires.2008.03.012
   Lit L, 2007, AM J MED GENET B, V144B, P958, DOI 10.1002/ajmg.b.30550
   Loiselle CR, 2003, PEDIATR NEUROL, V28, P119, DOI 10.1016/S0887-8994(02)00507-6
   Luo F, 2004, PEDIATRICS, V113, pE578, DOI 10.1542/peds.113.6.e578
   Martino D, 2007, MOVEMENT DISORD, V22, P1424, DOI 10.1002/mds.21454
   Martino D, 2011, DEV MED CHILD NEUROL, V53, P951, DOI 10.1111/j.1469-8749.2011.04018.x
   Martino D, 2009, MOVEMENT DISORD, V24, P1267, DOI 10.1002/mds.22504
   Mell LK, 2005, PEDIATRICS, V116, P56, DOI 10.1542/peds.2004-2058
   MIN S K, 1991, Yonsei Medical Journal, V32, P315
   Moller JC, 2008, EUR J NEUROL, V15, P749, DOI 10.1111/j.1468-1331.2008.02159.x
   Morer A, 2010, BRAIN BEHAV IMMUN, V24, P1069, DOI 10.1016/j.bbi.2010.02.007
   Morris CM, 2009, J NEUROL SCI, V276, P45, DOI 10.1016/j.jns.2008.08.032
   Morshed SA, 2001, BIOL PSYCHIAT, V50, P566, DOI 10.1016/S0006-3223(01)01096-4
   Muller N, 2004, PSYCHIAT RES, V129, P119, DOI 10.1016/j.psychres.2004.04.009
   Murphy TK, 2010, J NEUROIMMUNOL, V229, P243, DOI 10.1016/j.jneuroim.2010.08.017
   Perlmutter SJ, 1999, LANCET, V354, P1153, DOI 10.1016/S0140-6736(98)12297-3
   Riedel M, 1998, LANCET, V351, P418, DOI 10.1016/S0140-6736(05)78357-4
   Sarkar C, 2010, BRAIN BEHAV IMMUN, V24, P525, DOI 10.1016/j.bbi.2009.10.015
   Schoenian S, 2003, AM J MED GENET B, V119B, P60, DOI 10.1002/ajmg.b.20003
   Singer HS, 2005, J NEUROIMMUNOL, V163, P8, DOI 10.1016/j.jneuroim.2005.02.018
   Singer HS, 1999, BIOL PSYCHIAT, V46, P775, DOI 10.1016/S0006-3223(98)00384-9
   Singer HS, 2008, PEDIATRICS, V121, P1198, DOI 10.1542/peds.2007-2658
   Singer HS, 2005, NEUROLOGY, V65, P1701, DOI 10.1212/01.wnl.0000183223.69946.f1
   Singer HS, 1997, MOVEMENT DISORD, V12, P738, DOI 10.1002/mds.870120518
   Swedo SE, 1998, AM J PSYCHIAT, V155, P264
   Sweeten TL, 2003, PEDIATRICS, V112, pE420, DOI 10.1542/peds.112.5.e420
   Taylor JR, 2002, AM J PSYCHIAT, V159, P657, DOI 10.1176/appi.ajp.159.4.657
   Warren BP, 1994, ARCH PEDIAT ADOLESC, V148, P180
   Weisz JL, 2004, CLIN DIAGN LAB IMMUN, V11, P330, DOI 10.1128/CDLI.11.2.330-336.2004
   Wenzel C, 2011, MOVEMENT DISORD, V26, P343, DOI 10.1002/mds.23403
   Yirmiya R, 2011, BRAIN BEHAV IMMUN, V25, P181, DOI 10.1016/j.bbi.2010.10.015
NR 64
TC 5
Z9 5
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 0953-4180
J9 BEHAV NEUROL
JI Behav. Neurol.
PY 2013
VL 27
IS 1
SI SI
BP 23
EP 32
DI 10.3233/BEN-120295
PG 10
WC Clinical Neurology
SC Neurosciences & Neurology
GA 135BO
UT WOS:000318261200005
PM 23187145
ER

PT J
AU Iourov, IY
   Vorsanova, SG
   Yurov, YB
AF Iourov, I. Y.
   Vorsanova, S. G.
   Yurov, Y. B.
TI Somatic Cell Genomics of Brain Disorders: A New Opportunity to Clarify
   Genetic-Environmental Interactions
SO CYTOGENETIC AND GENOME RESEARCH
LA English
DT Article
DE Brain disorders; Genome-wide association hypothesis;
   Mosaicism-genetic-environmental interactions; Somatic genome variations
ID ATAXIA-TELANGIECTASIA BRAIN; CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE;
   DNA-REPLICATION; NEUROPSYCHIATRIC DISORDERS; INTERPHASE CHROMOSOMES;
   WIDE ASSOCIATION; ANEUPLOIDY; AUTISM; MOSAICISM
AB Recent genomic advances have exacerbated the problem of interpreting genome-wide association studies aimed at uncovering genetic basis of brain disorders. Despite of a plethora of data on candidate genes determining the susceptibility to neuropsychiatric diseases, no consensus is reached on their intrinsic contribution to the pathogenesis, and the influence of the environment on these genes is incompletely understood. Alternatively, single-cell analyses of the normal and diseased human brain have shown that somatic genome/epigenome variations (somatic mosaicism) do affect neuronal cell populations and are likely to mediate pathogenic processes associated with brain dysfunctions. Such (epi-)genomic changes are likely to arise from disturbances in genome maintenance and cell cycle regulation pathways as well as from environmental exposures. Therefore, one can suggest that, at least in a proportion of cases, inter- and intragenic variations (copy number variations (CNVs) or single nucleotide polymorphisms (SNPs)) associated with major brain disorders (i.e. schizophrenia, Alzheimer's disease, autism) lead to genetic dysregulation resulting in somatic genetic and epigenetic mosaicism. In addition, environmental influences on malfunctioning cellular machinery could trigger a cascade of abnormal processes producing genomic/chromosomal instability (i.e. brain-specific aneuploidy). Here, a brief analysis of a genome-wide association database has allowed us to support these speculations. Accordingly, an ontogenetic 2-/multiple-hit mechanism of brain diseases was hypothesized. Finally, we speculate that somatic cell genomics approach considering both genome-wide associations and somatic (epi-)genomic variations is likely to have bright perspectives for disease-oriented genome research. Copyright (C) 2013 S. Karger AG, Basel
C1 [Iourov, I. Y.; Vorsanova, S. G.; Yurov, Y. B.] Russian Acad Med Sci, Mental Hlth Res Ctr, RU-119152 Moscow, Russia.
   [Iourov, I. Y.; Vorsanova, S. G.; Yurov, Y. B.] Moscow State Univ Psychol & Educ, Minist Hlth & Social Dev, Inst Pediat & Children Surg, Moscow, Russia.
   [Vorsanova, S. G.; Yurov, Y. B.] Moscow State Univ Psychol & Educ, Ctr Neurobiol Diag Genet Psychiat Disorders, Moscow, Russia.
RP Iourov, IY (reprint author), Russian Acad Med Sci, Mental Hlth Res Ctr, Zagorodnoe Sh 2, RU-119152 Moscow, Russia.
EM ivan.iourov@gmail.com
RI Iourov, Ivan/O-7684-2014
OI Iourov, Ivan/0000-0002-4134-8367
CR Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
   Arendt T, 2010, AM J PATHOL, V177, P15, DOI 10.2353/ajpath.2010.090955
   Borysov SI, 2011, CELL CYCLE, V10, P1397, DOI 10.4161/cc.10.9.15478
   Celestino-Soper PBS, 2012, MOL CYTOGENET, V5, DOI 10.1186/1755-8166-5-17
   Chan WY, 2002, ANAT REC, V267, P261, DOI 10.1002/ar.10100
   Chow ML, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002592
   de Graaf-Peters VB, 2006, EARLY HUM DEV, V82, P257, DOI 10.1016/j.earlhumdev.2005.10.013
   Geller LN, 1999, NEUROBIOL DIS, V6, P167, DOI 10.1006/nbdi.1999.0236
   Geschwind DH, 2009, NATURE, V461, P908, DOI 10.1038/nature08537
   Ginsberg SD, 2004, NEUROCHEM RES, V29, P1053, DOI 10.1023/B:NERE.0000023593.77052.f7
   Girirajan S, 2010, HUM MOL GENET, V19, pR176, DOI 10.1093/hmg/ddq366
   Granic A, 2010, MOL BIOL CELL, V21, P511, DOI 10.1091/mbc.E09-10-0850
   Heng HHQ, 2011, GENOMICS, V98, P242, DOI 10.1016/j.ygeno.2011.05.008
   Herrup K, 2007, NAT REV NEUROSCI, V8, P368, DOI 10.1038/nrn2124
   Hindorff LA, 2009, P NATL ACAD SCI USA, V106, P9362, DOI 10.1073/pnas.0903103106
   Hochstenbach R, 2011, CYTOGENET GENOME RES, V135, P174, DOI 10.1159/000332928
   Iourov IY, 2010, CURR GENOMICS, V11, P387, DOI 10.2174/138920210793176065
   Iourov IY, 2009, NEUROBIOL DIS, V34, P212, DOI 10.1016/j.nbd.2009.01.003
   Iourov IY, 2006, INT REV CYTOL, V249, P143, DOI 10.1016/S0074-7696(06)49003-3
   Iourov IY, 2009, HUM MOL GENET, V18, P2656, DOI 10.1093/hmg/ddp207
   Iourov IY, 2011, NEURODEGENER DIS, V8, P35, DOI 10.1159/000315398
   Iourov IY, 2008, MOL CYTOGENET, V1, DOI 10.1186/1755-8166-1-26
   Iourov IY, 2008, CURR GENOMICS, V9, P452, DOI 10.2174/138920208786241216
   Iourov IY, 2006, CHROMOSOME RES, V14, P223, DOI 10.1007/s10577-006-1037-6
   Kingsbury MA, 2006, CELL MOL LIFE SCI, V63, P2626, DOI 10.1007/s00018-006-6169-5
   Leblond CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002521
   Mosch B, 2007, J NEUROSCI, V27, P6859, DOI 10.1523/JNEUROSCI.0379-07.2007
   Pearson TA, 2008, JAMA-J AM MED ASSOC, V299, P1335, DOI 10.1001/jama.299.11.1335
   Poot M, 2011, CYTOGENET GENOME RES, V135, P228, DOI 10.1159/000334064
   Visscher PM, 2012, AM J HUM GENET, V90, P7, DOI 10.1016/j.ajhg.2011.11.029
   Voineagu I, 2012, NEUROBIOL DIS, V45, P69, DOI 10.1016/j.nbd.2011.07.017
   Vorsanova SG, 2010, MOL CYTOGENET, V3, DOI 10.1186/1755-8166-3-1
   Vorsanova SG, 2009, ZH NEVROL PSIKHIATR, V109, P54
   Wang W, 2009, PROG NEUROBIOL, V89, P1, DOI 10.1016/j.pneurobio.2009.01.007
   Westra JW, 2010, J COMP NEUROL, V518, P3981, DOI 10.1002/cne.22436
   Westra JW, 2009, NEURODEGENER DIS, V6, P221, DOI 10.1159/000236901
   Westra JW, 2008, J COMP NEUROL, V507, P1944, DOI 10.1002/cne.21648
   Wu C, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-11-r130
   Yang Y, 2001, J NEUROSCI, V21, P2661
   Yurov YB, 2008, SCHIZOPHR RES, V98, P139, DOI 10.1016/j.schres.2007.07.035
   Yurov YB, 2005, J HISTOCHEM CYTOCHEM, V53, P385, DOI 10.1369/jhc.4A6430.2005
   Yurov YB, 2009, MOL CYTOGENET, V2, DOI 10.1186/1755-8166-2-23
   Yurov YB, 2007, J MED GENET, V44, P521, DOI 10.1136/jmg.2007.049312
   Yurov YB, 2001, BRAIN DEV-JPN, V23, pS186, DOI 10.1016/S0387-7604(01)00363-1
   Yurov YB, 2011, THESCIENTIFICWORLDJO, V11, P2602, DOI 10.1100/2011/625690
   Yurov YB, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000558
   Yurov YB, 2010, CURR GENOMICS, V11, P420, DOI 10.2174/138920210793175958
   Zhu XW, 2004, LANCET NEUROL, V3, P219, DOI 10.1016/S1474-4422(04)00707-0
NR 48
TC 6
Z9 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1424-8581
J9 CYTOGENET GENOME RES
JI Cytogenet. Genome Res.
PY 2013
VL 139
IS 3
BP 181
EP 188
DI 10.1159/000347053
PG 8
WC Cell Biology; Genetics & Heredity
SC Cell Biology; Genetics & Heredity
GA 137YS
UT WOS:000318475100006
PM 23428498
ER

PT J
AU Abu-Asab, MS
   Abu-Asab, N
   Loffredo, CA
   Clarke, R
   Amri, H
AF Abu-Asab, M. S.
   Abu-Asab, N.
   Loffredo, C. A.
   Clarke, R.
   Amri, H.
TI Identifying Early Events of Gene Expression in Breast Cancer with
   Systems Biology Phylogenetics
SO CYTOGENETIC AND GENOME RESEARCH
LA English
DT Article
DE Cancer; Early events; Heterogeneity; Parsimony; Phylogenetics;
   Synapomorphies; Systems biology
ID EPIGENETIC HETEROGENEITY; MEDICINE; ACCUMULATION; EPITHELIUM; MUTATIONS;
   THERAPY; GENOME
AB Advanced omics technologies such as deep sequencing and spectral karyotyping are revealing more of cancer heterogeneity at the genetic, genomic, gene expression, epigenetic, proteomic, and metabolomic levels. With this increasing body of emerging data, the task of data analysis becomes critical for mining and modeling to better understand the relevant underlying biological processes. However, the multiple levels of heterogeneity evident within and among populations, healthy and diseased, complicate the mining and interpretation of biological data, especially when dealing with hundreds to tens of thousands of variables. Heterogeneity occurs in many diseases, such as cancers, autism, macular degeneration, and others. In cancer, heterogeneity has hampered the search for validated biomarkers for early detection, and it has complicated the task of finding clonal (driver) and nonclonal (nonexpanded or passenger) aberrations. We show that subtyping of cancer (classification of specimens) should be an a priori step to the identification of early events of cancers. Studying early events in oncogenesis can be done on histologically normal tissues from diseased individuals (HNTDI), since they most likely have been exposed to the same mutagenic insults that caused the cancer in their neighboring tissues. Polarity assessment of HNTDI data variables by using healthy specimens as outgroup(s), followed by the application of parsimony phylogenetic analysis, produces a hierarchical classification of specimens that reveals the early events of the disease ontogeny within its subtypes as shared derived changes (abnormal changes) or synapomorphies in phylogenetic terminology. Copyright (C) 2013 S. Karger AG, Basel
C1 [Abu-Asab, M. S.] NEI, Immunopathol Sect, NIH, Bethesda, MD 20892 USA.
   [Loffredo, C. A.] Georgetown Univ, Sch Med, Dept Biostat Bioinformat & Biomath, Washington, DC USA.
   [Loffredo, C. A.; Clarke, R.] Georgetown Univ, Sch Med, Lombardi Comprehens Canc Ctr, Dept Oncol, Washington, DC 20005 USA.
   [Amri, H.] Georgetown Univ, Sch Med, Dept Biochem Cellular & Mol Biol, Washington, DC 20057 USA.
   [Abu-Asab, N.] Univ New England, Armidale Rural Referral Hosp, Armidale, NSW, Australia.
   [Abu-Asab, N.] Univ Newcastle, Armidale, NSW, Australia.
RP Amri, H (reprint author), Georgetown Univ, Sch Med, Dept Biochem Cellular & Mol Biol, 217 Basic Sci Bldg,3900 Reservoir Rd, Washington, DC 20057 USA.
EM amrih@georgetown.edu
RI Clarke, Robert/A-6485-2008
OI Clarke, Robert/0000-0002-9278-0854
CR Abu-Asab M, 2008, PROTEOM CLIN APPL, V2, P122, DOI 10.1002/prca.200780047
   Abu-Asab M, 2006, J PROTEOME RES, V5, P2236, DOI 10.1021/pr0504485
   Abu-Asab MS, 2008, OMICS, V12, P183, DOI 10.1089/omi.2008.0010
   Abu-Asab MS, 2011, OMICS, V15, P105, DOI 10.1089/omi.2010.0023
   Berman J, 2010, PRECANCER BEGINNING
   Bozic I, 2010, P NATL ACAD SCI USA, V107, P18545, DOI 10.1073/pnas.1010978107
   Buchen L, 2011, NATURE, V471, P428, DOI 10.1038/471428a
   Chen DT, 2010, BREAST CANCER RES TR, V119, P335, DOI 10.1007/s10549-009-0344-y
   Clarke R, 2008, NAT REV CANCER, V8, P37, DOI 10.1038/nrc2294
   Couzin-Frankel J, 2011, SCIENCE, V333, P1569, DOI 10.1126/science.333.6049.1569
   Daley GQ, 2008, COLD SH Q B, V73, P171, DOI 10.1101/sqb.2008.73.041
   Diamandis EP, 2010, J NATL CANCER I, V102, P1462, DOI 10.1093/jnci/djq306
   Felsenstein J., 1989, CLADISTICS, V5, P164, DOI DOI 10.1111/J.1096-0031.1989.TB00562.X
   Fendt L, 2011, BREAST CANCER RES TR, V128, P327, DOI 10.1007/s10549-010-1092-8
   Ganeshan Balaji, 2011, Front Oncol, V1, P33, DOI 10.3389/fonc.2011.00033
   Goldstein DB, 2007, AM J MED, V120, P21, DOI 10.1016/j.amjmed.2007.02.004
   Graham K, 2010, BRIT J CANCER, V102, P1284, DOI 10.1038/sj.bjc.6605576
   Heng HHO, 2011, ADV CANCER RES, V112, P217, DOI 10.1016/B978-0-12-387688-1.00008-9
   Heng HH, 2010, CURR DRUG TARGETS, V11, P1304
   Heng HHQ, 2011, GENOMICS, V98, P242, DOI 10.1016/j.ygeno.2011.05.008
   Heng HHQ, 2009, J CELL PHYSIOL, V220, P538, DOI 10.1002/jcp.21799
   HEPPNER GH, 1983, CANCER METAST REV, V2, P5, DOI 10.1007/BF00046903
   Koturbash I, 2011, TOXICOL MECH METHOD, V21, P289, DOI 10.3109/15376516.2011.557881
   Landen CN, 2008, J CLIN ONCOL, V26, P995, DOI 10.1200/JCO.2006.07.9970
   Loeb LA, 2008, CANCER RES, V68, P3551, DOI 10.1158/0008-5472.CAN-07-5835
   Lyons-Weiler J, 2004, BMC BIOINFORMATICS, V5, DOI 10.1186/1471-2105-5-110
   Michor F, 2010, CANCER PREV RES, V3, P1361, DOI 10.1158/1940-6207.CAPR-10-0234
   Pogribny I. P., 2010, Experimental Oncology, V32, P132
   RANZANI GN, 1995, CANCER EPIDEM BIOMAR, V4, P223
   Sumer B, 2008, NANOMEDICINE-UK, V3, P137, DOI 10.2217/17435889.3.2.137
   Tripathi A, 2008, INT J CANCER, V122, P1557, DOI 10.1002/ijc.23267
NR 31
TC 1
Z9 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1424-8581
J9 CYTOGENET GENOME RES
JI Cytogenet. Genome Res.
PY 2013
VL 139
IS 3
BP 206
EP 214
DI 10.1159/000348433
PG 9
WC Cell Biology; Genetics & Heredity
SC Cell Biology; Genetics & Heredity
GA 137YS
UT WOS:000318475100009
PM 23548567
ER

PT J
AU Farmer, C
   Thurm, A
   Grant, P
AF Farmer, Cristan
   Thurm, Audrey
   Grant, Paul
TI Pharmacotherapy for the Core Symptoms in Autistic Disorder: Current
   Status of the Research
SO DRUGS
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; PLACEBO-CONTROLLED TRIAL; OPEN-LABEL
   TRIAL; CONTROLLED CROSSOVER TRIAL; CONTROLLED PILOT TRIAL; BEHAVIOR
   RATING FORM; SPECTRUM DISORDERS; DOUBLE-BLIND; REPETITIVE BEHAVIORS;
   PSYCHIATRIC-DISORDERS
AB The current review covers extant literature on pharmacotherapy for core symptoms of autism. The core symptoms of autism include impairments in social interaction and communication, as well as the presence of restricted and repetitive behaviors. There are no known efficacious treatments for the core social symptoms, although effects on repetitive behaviors are indicated with some data. While studies of fenfluramine, secretin, opiates, and mood stabilizers generally find no effect, mixed results suggest more research is needed on antidepressants and atypical antipsychotics. Newer lines of research, including cholinergic and glutamatergic agents and oxytocin, will be of considerable interest in the future. However, research on the treatment of core symptoms is plagued by limitations in study design, statistical power, and other issues inherent to the study of treatments for autism (e.g., heterogeneity of the disorder) that continue to prevent the elucidation of efficacious treatments.
C1 [Farmer, Cristan; Thurm, Audrey; Grant, Paul] NIMH, Pediat & Dev Neurosci Branch, Bethesda, MD 20892 USA.
RP Farmer, C (reprint author), NIMH, Pediat & Dev Neurosci Branch, 10 Ctr Dr MSC 1255,Bldg 10,Room 1C250, Bethesda, MD 20892 USA.
EM farmerca@mail.nih.gov
FU National Institute of Mental Health (NIMH) of the National Institutes of
   Health (NIH)
FX This work was supported by the Intramural Program of the National
   Institute of Mental Health (NIMH) of the National Institutes of Health
   (NIH). The views expressed in this article do not necessarily represent
   the views of the NIMH, NIH, the Department of Health and Human Services,
   or the United States Government. The authors have no conflicts of
   interest to report.
CR Aman MG, 2009, J AM ACAD CHILD PSY, V48, P1143, DOI 10.1097/CHI.0b013e3181bfd669
   AMAN MG, 1985, AM J MENT DEF, V89, P485
   Aman MG, 1996, RES DEV DISABIL, V17, P41, DOI 10.1016/0891-4222(95)00039-9
   Aman MG, 2003, J AUTISM DEV DISORD, V33, P527, DOI 10.1023/A:1025883612879
   Aman MG, 2004, CNS SPECTRUMS, V9, P36
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   [Anonymous], 2002, N ENGL J MED, V347, P314
   Arnold LE, 2012, J CHILD ADOL PSYCHOP, V22, P198, DOI 10.1089/cap.2011.0056
   Asberg M, 1978, ACTA PSYCHIAT SCAN S, V271, P5
   Belsito KM, 2001, J AUTISM DEV DISORD, V31, P175, DOI 10.1023/A:1010799115457
   BOUVARD MP, 1995, PSYCHIAT RES, V58, P191, DOI 10.1016/0165-1781(95)02601-R
   Buckley AW, 2011, J CHILD ADOL PSYCHOP, V21, P353, DOI 10.1089/cap.2010.0121
   CAMPBELL M, 1988, J AM ACAD CHILD PSY, V27, P434, DOI 10.1097/00004583-198807000-00010
   CAMPBELL M, 1993, J AM ACAD CHILD PSY, V32, P1283, DOI 10.1097/00004583-199311000-00024
   Chadman KK, 2012, EXPERT OPIN DRUG DIS, V7, P407, DOI 10.1517/17460441.2012.678828
   Chez MG, 2003, J PEDIAT NEUROL, V1, P83
   Chez MG, 2004, J CHILD NEUROL, V19, P165
   Chez MG, 2007, J CHILD NEUROL, V22, P574, DOI 10.1177/0883073807302611
   Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008
   Deutsch SI, 2010, CLIN NEUROPHARMACOL, V33, P114, DOI 10.1097/WNF.0b013e3181d6f7ad
   Doyle CA, 2012, EXPERT OPIN PHARMACO, V13, P1615, DOI 10.1517/14656566.2012.674110
   Doyle Robert L, 2006, J Atten Disord, V9, P543, DOI 10.1177/1087054705284091
   ElChaar GM, 2006, ANN PHARMACOTHER, V40, P1086, DOI 10.1345/aph.1G499
   Ellenbogen MA, 2012, PSYCHOPHYSIOLOGY, V49, P128, DOI 10.1111/j.1469-8986.2011.01278.x
   Erickson CA, 2011, J CHILD ADOL PSYCHOP, V21, P565, DOI 10.1089/cap.2011.0034
   Erickson CA, 2007, PSYCHOPHARMACOLOGY, V191, P141, DOI 10.1007/s00213-006-0518-9
   Farmer CA, 2011, EXPERT OPIN PHARMACO, V12, P635, DOI 10.1517/14656566.2011.557661
   Gelenberg AJ, 2008, J CLIN PSYCHIAT, V69, P1513
   GELLER E, 1982, NEW ENGL J MED, V307, P165, DOI 10.1056/NEJM198207153070307
   Goff DC, 1999, ARCH GEN PSYCHIAT, V56, P21, DOI 10.1001/archpsyc.56.1.21
   GORDON CT, 1993, ARCH GEN PSYCHIAT, V50, P441
   Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020
   Hardan AY, 2002, J CHILD ADOL PSYCHOP, V12, P237, DOI 10.1089/104454602760386923
   Hardan AY, 2012, BIOL PSYCHIAT, V71, P956, DOI 10.1016/j.biopsych.2012.01.014
   Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
   Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030
   Hollander E, 2001, J CLIN PSYCHIAT, V62, P530
   Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627
   Hollander E, 2006, INT J NEUROPSYCHOPH, V9, P209, DOI 10.1017/S1461145705005791
   Hollander E, 2012, AM J PSYCHIAT, V169, P292, DOI 10.1176/appi.ajp.2011.10050764
   Hollander E, 2010, NEUROPSYCHOPHARMACOL, V35, P990, DOI 10.1038/npp.2009.202
   Horvath K, 1998, J Assoc Acad Minor Phys, V9, P9
   Indah Winarni T, 2012, AUTISM RES TREAT, V2012
   Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005
   Jacquemont S., 2011, SCI TRANSL MED, V3, p64ra1
   King BH, 2001, J AM ACAD CHILD PSY, V40, P658, DOI 10.1097/00004583-200106000-00010
   King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30
   Kobak KA, 2007, J CLIN PSYCHOPHARM, V27, P1, DOI 10.1097/JCP.0b013e31802eb4b7
   Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644
   Lecavalier L, 2004, J AUTISM DEV DISORD, V34, P709, DOI 10.1007/s10803-004-5291-1
   LEVENTHAL BL, 1993, J NEUROPSYCH CLIN N, V5, P307
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   Lord C, 2012, J CHILD PSYCHOL PSYC, V53, P490, DOI 10.1111/j.1469-7610.2012.02547.x
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Mandell DS, 2008, PEDIATRICS, V121, pE441, DOI 10.1542/peds.2007-0984
   Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658
   Marcus RN, 2011, J CLIN PSYCHIAT, V72, P1270, DOI 10.4088/JCP.09m05933
   McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P1001
   McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142
   McDougle CJ, 2005, J CLIN PSYCHIAT, V66, P9
   Nicolson R, 2006, J CHILD ADOL PSYCHOP, V16, P621, DOI 10.1089/cap.2006.16.621
   Niederhofer H, 2007, J CHILD NEUROL, V22, P1054, DOI 10.1177/0883073807305857
   Niederhofer H, 2007, J CLIN PSYCHOPHARM, V27, P317, DOI 10.1097/01.jcp.0000270082.30500.69
   Niederhofer H, 2002, BRIT MED J, V325, P1422
   Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782
   Owley T, 2006, J CHILD ADOL PSYCHOP, V16, P517, DOI 10.1089/cap.2006.16.517
   PANKSEPP J, 1979, PHARMACOL BIOCHEM BE, V11, P131, DOI 10.1016/0091-3057(79)90002-9
   Posey DJ, 2008, CHILD ADOL PSYCH CL, V17, P787, DOI 10.1016/j.chc.2008.06.010
   Posey DJ, 2004, AM J PSYCHIAT, V161, P2115, DOI 10.1176/appi.ajp.161.11.2115
   Posey DJ, 2006, J CHILD ADOL PSYCHOP, V16, P181, DOI 10.1089/cap.2006.16.181
   Remington G, 2001, J CLIN PSYCHOPHARM, V21, P440, DOI 10.1097/00004714-200108000-00012
   Rimmele U, 2009, J NEUROSCI, V29, P38, DOI 10.1523/JNEUROSCI.4260-08.2009
   RITVO ER, 1986, PSYCHOPHARMACOL BULL, V22, P133
   Sandler AD, 2000, J DEV BEHAV PEDIATR, V21, P347
   Scahill L, 1997, J AM ACAD CHILD PSY, V36, P844, DOI 10.1097/00004583-199706000-00023
   Scahill L, 2012, J AUTISM DEV DISORD, V42, P432, DOI 10.1007/s10803-011-1251-8
   Scahill L, 2013, J AUTISM DEV DISORD, V24, P739
   Scahill L, 2006, J AM ACAD CHILD PSY, V45, P1114, DOI 10.1097/01.chi.0000220854.79144.e7
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Scott Lesley J, 2007, Paediatr Drugs, V9, P343
   Shea S, 2004, PEDIATRICS, V114, pE634, DOI 10.1542/peds.2003-0264-F
   SHERMAN J, 1989, J AUTISM DEV DISORD, V19, P533, DOI 10.1007/BF02212856
   Siegel M, 2012, J AUTISM DEV DISORD, V42, P1592, DOI 10.1007/s10803-011-1399-2
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   STERN LM, 1990, J CHILD PSYCHOL PSYC, V31, P569, DOI 10.1111/j.1469-7610.1990.tb00798.x
   Stigler KA, 2012, PSYCHOPHARMACOLOGY, V223, P237, DOI 10.1007/s00213-012-2711-3
   Wasserman S, 2006, INT CLIN PSYCHOPHARM, V21, P363, DOI 10.1097/01.yic.0000224787.13782.0f
   WILLEMSENSWINKELS SHN, 1995, PSYCHIAT RES, V58, P203, DOI 10.1016/0165-1781(95)02749-M
   Williams KW, 2005, COCHRANE DB SYST REV
   Yasuhara A, 2010, BRAIN DEV-JPN, V32, P791, DOI 10.1016/j.braindev.2010.08.010
NR 92
TC 9
Z9 9
PU ADIS INT LTD
PI AUCKLAND
PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW
   ZEALAND
SN 0012-6667
J9 DRUGS
JI Drugs
PY 2013
VL 73
IS 4
BP 303
EP 314
DI 10.1007/s40265-013-0021-7
PG 12
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 138UP
UT WOS:000318535800002
PM 23504356
ER

PT J
AU Ruckmann, J
   Rief, W
AF Ruckmann, Judith
   Rief, Winfried
TI Empathy: Neuroscientific Background, Clinical Implications, and Open
   Questions
SO VERHALTENSTHERAPIE
LA German
DT Review
DE Empathy; Review; Psychotherapy; Emotion regulation; Neuroscience
ID BORDERLINE PERSONALITY-DISORDER; OBSESSIVE-COMPULSIVE DISORDER;
   DIALECTICAL BEHAVIOR-THERAPY; MIRROR-NEURON SYSTEM; AUTISM SPECTRUM
   DISORDERS; EMOTION REGULATION; SOCIAL COGNITION; FACIAL EXPRESSIONS;
   BIPOLAR DISORDER; CHRONIC PAIN
AB Empathy as therapist variable has been an important focus of psychotherapy research. However, empathy as a patient variable might also influence the treatment outcome. Altered empathetic experience as part of clinical symptomatology has rarely been in the focus of clinical psychological research. Concepts such as perspective taking/theory of mind, regulation of emotion, and alexithymia are typically examined, but not empathy by itself. This review aims to summarize findings from neuroscience regarding empathy and to illustrate disorder-specific alterations in experiencing/ perceiving empathy. It will be discussed how these findings can be used in psychotherapeutic settings in order to generate new approaches in interventions.
C1 [Ruckmann, Judith; Rief, Winfried] Univ Marburg, AG Klin Psychol & Psychotherapie, D-35032 Marburg, Germany.
RP Ruckmann, J (reprint author), Univ Marburg, AG Klin Psychol & Psychotherapie, Gutenbergstr 18, D-35032 Marburg, Germany.
EM ruckmann@staff.uni-marburg.de
CR Akitsuki Y, 2009, NEUROIMAGE, V47, P722, DOI 10.1016/j.neuroimage.2009.04.091
   Amstadter A, 2008, J ANXIETY DISORD, V22, P211, DOI 10.1016/j.janxdis.2007.02.004
   Avenanti A, 2006, NEUROIMAGE, V32, P316, DOI 10.1016/j.neuroimage.2006.03.010
   Avenanti A, 2010, CURR BIOL, V20, P1018, DOI 10.1016/j.cub.2010.03.071
   Avenanti A, 2009, NEUROIMAGE, V44, P275, DOI 10.1016/j.neuroimage.2008.08.001
   Batson CD, 1997, J PERS SOC PSYCHOL, V73, P495, DOI 10.1037/0022-3514.73.3.495
   BATSON CD, 1987, J PERS, V55, P19, DOI 10.1111/j.1467-6494.1987.tb00426.x
   BATSON CD, 1991, J PERS SOC PSYCHOL, V61, P413, DOI 10.1037/0022-3514.61.3.413
   Beblo HT, 2010, J NERV MENT DIS, V198, P385
   Benedetti F, 2009, SCHIZOPHR RES, V114, P154, DOI 10.1016/j.schres.2009.06.021
   Berking M., 2010, TRAINING EMOTIONALER
   Bird G, 2010, BRAIN, V133, P1515, DOI 10.1093/brain/awq060
   Blair RJR, 2008, Q J EXP PSYCHOL, V61, P157, DOI 10.1080/17470210701508855
   Blair RJR, 2005, CONSCIOUS COGN, V14, P698, DOI 10.1016/j.concog.2005.06.004
   Bora E, 2008, PSYCHIAT RES, V160, P23, DOI 10.1016/j.psychres.2007.05.017
   Botvinick M, 2005, NEUROIMAGE, V25, P312, DOI 10.1016/j.neuroimage.2004.11.043
   Bozikas VP, 2007, J NEUROPSYCH CLIN N, V19, P436, DOI 10.1176/appi.neuropsych.19.4.436
   Budell L, 2010, NEUROIMAGE, V53, P355, DOI 10.1016/j.neuroimage.2010.05.037
   Burba B, 2006, CAN J PSYCHIAT, V51, P468
   Cattaneo L, 2009, ARCH NEUROL-CHICAGO, V66, P557, DOI 10.1001/archneurol.2009.41
   Cheng YW, 2007, CURR BIOL, V17, P1708, DOI 10.1016/j.cub.2007.09.020
   Cheng YW, 2010, NEUROIMAGE, V51, P923, DOI 10.1016/j.neuroimage.2010.02.047
   Clark TF, 2008, EMOTION, V8, P803, DOI 10.1037/a0014124
   Connelly M, 2007, J PSYCHOSOM RES, V62, P649, DOI 10.1016/j.jpsychores.2006.12.008
   Cornelio-Nieto J O, 2009, Rev Neurol, V48 Suppl 2, pS27
   Cusi A, 2010, PSYCHIAT RES, V178, P354, DOI 10.1016/j.psychres.2009.07.009
   Danziger N, 2006, BRAIN, V129, P2494, DOI 10.1093/brain/awl155
   Danziger N, 2009, NEURON, V61, P203, DOI 10.1016/j.neuron.2008.11.023
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
   Decety Jean, 2007, Biopsychosoc Med, V1, P22, DOI 10.1186/1751-0759-1-22
   Decety J, 2006, THESCIENTIFICWORLDJO, V6, P1146, DOI 10.1100/tsw.2006.221
   Decety J, 2010, J COGNITIVE NEUROSCI, V22, P985, DOI 10.1162/jocn.2009.21266
   Decety J, 2010, NEUROIMAGE, V50, P1676, DOI 10.1016/j.neuroimage.2010.01.025
   Demenescu LR, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015058
   de Vignemont F, 2006, TRENDS COGN SCI, V10, P435, DOI 10.1016/j.tics.2006.08.008
   Dilling H, 2008, INT KLASSIFIKATION P
   Donges US, 2005, J NERV MENT DIS, V193, P331, DOI 10.1097/01.nmd.0000161683.02482.19
   Doody GA, 1998, PSYCHOL MED, V28, P397, DOI 10.1017/S003329179700648X
   Dorard G, 2008, EUR CHILD ADOLES PSY, V17, P274, DOI 10.1007/s00787-007-0663-7
   Dyck MJ, 2001, EUR CHILD ADOLES PSY, V10, P105
   Dziobek I, 2011, Z KINDER JUG-PSYCH, V39, P79, DOI 10.1024/1422-4917/a000094
   Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x
   Dziobek I, 2011, NEUROIMAGE, V57, P539, DOI 10.1016/j.neuroimage.2011.05.005
   Fan Y, 2011, PSYCHOL MED, V41, P1641, DOI 10.1017/S003329171000228X
   Fontenelle LF, 2009, J PSYCHIATR RES, V43, P455, DOI 10.1016/j.jpsychires.2008.05.007
   Frith CD, 2004, PSYCHOL MED, V34, P385, DOI 10.1017/S0033291703001326
   Frith CD, 1999, SCIENCE, V286, P1692, DOI 10.1126/science.286.5445.1692
   Gallese V, 2003, PSYCHOPATHOLOGY, V36, P171, DOI 10.1159/000072786
   Gallese V, 1998, TRENDS COGN SCI, V2, P493, DOI 10.1016/S1364-6613(98)01262-5
   Gerdes KE, 2011, J SOC SERV RES, V37, P230, DOI 10.1080/01488376.2011.564027
   Goldin PR, 2010, EMOTION, V10, P83, DOI 10.1037/a0018441
   Graybiel AM, 2000, NEURON, V28, P343, DOI 10.1016/S0896-6273(00)00113-6
   Greimel E, 2010, NEUROIMAGE, V49, P1055, DOI 10.1016/j.neuroimage.2009.07.057
   Gu XS, 2007, NEUROIMAGE, V36, P256, DOI 10.1016/j.neuroimage.2007.02.025
   Gu XS, 2010, J NEUROSCI, V30, P3739, DOI 10.1523/JNEUROSCI.4844-09.2010
   Guttman H, 2002, COMPR PSYCHIAT, V43, P448, DOI 10.1053/comp.2002.35905
   Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
   Hall RCW, 2007, MAYO CLIN PROC, V82, P457
   Han SH, 2008, BRAIN RES, V1196, P85, DOI 10.1016/j.brainres.2007.12.062
   Harari H, 2010, PSYCHIAT RES, V175, P277, DOI 10.1016/j.psychres.2009.03.002
   Harrison A, 2009, CLIN PSYCHOL PSYCHOT, V16, P348, DOI 10.1002/cpp.628
   Harrison A, 2010, BIOL PSYCHIAT, V68, P755, DOI 10.1016/j.biopsych.2010.04.037
   Hayes S. C., 1999, ACCEPTANCE COMMITMEN
   Hein G, 2008, CURR OPIN NEUROBIOL, V18, P153, DOI 10.1016/j.conb.2008.07.012
   Hein G, 2010, NEURON, V68, P149, DOI 10.1016/j.neuron.2010.09.003
   HOEHNSARIC R, 1991, AM J PSYCHIAT, V148, P1243
   Hoffman Martin L., 2000, EMPATHY MORAL DEV IM
   Hollander E, 1996, INT CLIN PSYCHOPHARM, V11, P75, DOI 10.1097/00004850-199612005-00007
   Ibarraran-Pernas GY, 2003, ACTAS ESP PSIQUIATRI, V31, P256
   Jackson PL, 2005, NEUROIMAGE, V24, P771, DOI 10.1016/j.neuroimage.2004.09.006
   Jackson PL, 2006, PAIN, V125, P5, DOI 10.1016/j.pain.2006.09.013
   Jackson PL, 2006, NEUROPSYCHOLOGIA, V44, P752, DOI 10.1016/j.neuropsychologia.2005.07.015
   Jones AP, 2010, J CHILD PSYCHOL PSYC, V51, P1188, DOI 10.1111/j.1469-7610.2010.02280.x
   KABATZINN J, 1985, J BEHAV MED, V8, P163, DOI 10.1007/BF00845519
   KABATZINN J, 1992, AM J PSYCHIAT, V149, P936
   KABATZINN J, 1982, GEN HOSP PSYCHIAT, V4, P33, DOI 10.1016/0163-8343(82)90026-3
   Kelley JM, 2009, PSYCHOSOM MED, V71, P789, DOI 10.1097/PSY.0b013e3181acee12
   Kessler H, 2010, PSYCHOTHER PSYCH MED, V60, P169, DOI 10.1055/s-0029-1234046
   Killgore WDS, 2008, SLEEP MED, V9, P517, DOI 10.1016/j.sleep.2007.07.003
   Kipps CM, 2009, NEUROCASE, V15, P182, DOI 10.1080/13554790802632892
   Kirchner JC, 2011, J AUTISM DEV DISORD, V41, P158, DOI 10.1007/s10803-010-1032-9
   Kooiman CG, 2000, PSYCHOSOM MED, V62, P768
   Korkmaz B, 2011, PEDIATR RES, V69, p101R, DOI 10.1203/PDR.0b013e318212c177
   Kucharska-Pietura K, 2004, INT J EAT DISORDER, V35, P42, DOI 10.1002/eat.10219
   Lamm C, 2007, J COGNITIVE NEUROSCI, V19, P42, DOI 10.1162/jocn.2007.19.1.42
   Lamm C, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001292
   Lamm C, 2010, BRAIN STRUCT FUNCT, V214, P579, DOI 10.1007/s00429-010-0251-3
   Langdon Robyn, 2006, Cogn Neuropsychiatry, V11, P133, DOI 10.1080/13546800444000218
   Lawrence EJ, 2004, PSYCHOL MED, V34, P911, DOI 10.1017/S0033291703001624
   Lee KH, 2004, PSYCHOL MED, V34, P391, DOI 10.1017/S0033291703001284
   Lee SJ, 2010, PSYCHIAT RES-NEUROIM, V181, P121, DOI 10.1016/j.pscychresns.2009.08.003
   Lincoln TM, 2011, SCHIZOPHRENIA BULL, V37, pS23, DOI 10.1093/schbul/sbr066
   Linehan MM, 1999, AM J ADDICTION, V8, P279
   Linehan MM, 2002, DRUG ALCOHOL DEPEN, V67, P13, DOI 10.1016/S0376-8716(02)00011-X
   LINEHAN MM, 1987, B MENNINGER CLIN, V51, P261
   Linehan MM, 2006, ARCH GEN PSYCHIAT, V63, P757, DOI 10.1001/archpsyc.63.7.757
   LINTON SJ, 1984, PROG BEHAV MODIFIC, V18, P1
   Lombardo MV, 2011, NEUROIMAGE, V56, P1832, DOI 10.1016/j.neuroimage.2011.02.067
   Lutz A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001897
   MANN LS, 1994, PSYCHOL REP, V74, P563
   Markey MA, 2007, COMPR PSYCHIAT, V48, P458, DOI 10.1016/j.comppsych.2007.05.006
   Marsh AA, 2011, J CHILD PSYCHOL PSYC, V52, P834, DOI 10.1111/j.1469-7610.2010.02353.x
   Martineau J, 2010, BRAIN RES, V1320, P168, DOI 10.1016/j.brainres.2010.01.035
   Mason P, 2010, SOCIAL NEUROSCI 0203, P1
   Mathur VA, 2010, NEUROIMAGE, V51, P1468, DOI 10.1016/j.neuroimage.2010.03.025
   McMain S, 2001, J CLIN PSYCHOL, V57, P183, DOI 10.1002/1097-4679(200102)57:2<183::AID-JCLP5>3.0.CO;2-Y
   Menzies L, 2008, NEUROSCI BIOBEHAV R, V32, P525, DOI 10.1016/j.neubiorev.2007.09.005
   Minio-Paluello I, 2009, BIOL PSYCHIAT, V65, P55, DOI 10.1016/j.biopsych.2008.08.006
   Montag C, 2007, SCHIZOPHR RES, V92, P85, DOI 10.1016/j.schres.2007.01.024
   Moriguchi Y, 2007, CEREB CORTEX, V17, P2223, DOI 10.1093/cercor/bhl130
   Moriguchi Y, 2009, HUM BRAIN MAPP, V30, P2063, DOI 10.1002/hbm.20653
   Morrison I, 2004, COGN AFFECT BEHAV NE, V4, P270, DOI 10.3758/CABN.4.2.270
   Paivio SC, 2001, J CLIN PSYCHOL, V57, P213, DOI 10.1002/1097-4679(200102)57:2<213::AID-JCLP7>3.0.CO;2-B
   PARKER JDA, 1993, PSYCHOTHER PSYCHOSOM, V59, P197
   Perner J, 1999, TRENDS COGN SCI, V3, P337, DOI 10.1016/S1364-6613(99)01362-5
   Peyron R, 2002, NEUROIMAGE, V17, P1336, DOI 10.1006/nimg.2002.1315
   Preston SD, 2002, BEHAV BRAIN SCI, V25, P1
   Preston SD, 2002, BEHAV BRAIN SCI, V25, P20
   Proverbio AM, 2009, NEUROPSYCHOLOGIA, V47, P2374, DOI 10.1016/j.neuropsychologia.2008.10.030
   Putnam KM, 2005, DEV PSYCHOPATHOL, V17, P899, DOI 10.1017/S0954579405050431
   Rameson LT, 2009, SOC PERSONAL PSYCHOL, V3, P94, DOI 10.1111/j.1751-9004.2008.00154.x
   Ritter K, 2011, PSYCHIAT RES, V187, P241, DOI 10.1016/j.psychres.2010.09.013
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   ROGERS CR, 1957, J CONSULT PSYCHOL, V21, P95, DOI 10.1037/h0045357
   Rosen IM, 2006, ACAD MED, V81, P82, DOI 10.1097/00001888-200601000-00020
   Saarela Miiamaaria V, 2007, Cereb Cortex, V17, P230, DOI 10.1093/cercor/bhj141
   Sambo CF, 2010, PAIN, V151, P687, DOI 10.1016/j.pain.2010.08.035
   SCHACHTER S, 1962, PSYCHOL REV, V69, P379, DOI 10.1037/h0046234
   Shamay-Tsoory S, 2009, J NEUROPSYCH CLIN N, V21, P59, DOI 10.1176/appi.neuropsych.21.1.59
   Shamay-Tsoory SG, 2007, PSYCHIAT RES, V149, P11, DOI 10.1016/j.psychres.2005.10.018
   Shamay-Tsoory SG, 2007, NEUROPSYCHOLOGIA, V45, P3054, DOI 10.1016/j.neuropsychologia.2007.05.021
   Shamay-Tsoory SG, 2007, NEUROPSYCHOLOGY, V21, P431, DOI 10.1037/0894-4105.21.4.431
   Shamay-Tsoory SG, 2010, CORTEX, V46, P668, DOI 10.1016/j.cortex.2009.04.008
   Shin YW, 2004, PSYCHIAT CLIN NEUROS, V58, P16, DOI 10.1111/j.1440-1819.2004.01186.x
   Shur Syvan, 2008, Cogn Neuropsychiatry, V13, P472, DOI 10.1080/13546800802490034
   SIFNEOS PE, 1973, PSYCHOTHER PSYCHOSOM, V22, P255
   SIFNEOS PE, 1988, PSYCHIAT CLIN N AM, V11, P287
   Singer T, 2006, NEUROSCI BIOBEHAV R, V30, P855, DOI 10.1016/j.neubiorev.2006.06.011
   Singer T, 2004, SCIENCE, V303, P1157, DOI 10.1126/science.1093535
   Sommer M, 2006, PROG BRAIN RES, V156, P457, DOI 10.1016/S0079-6123(06)56025-X
   Sparks A, 2010, SCHIZOPHR RES, V122, P172, DOI 10.1016/j.schres.2010.06.011
   Sugranyes G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025322
   Swart M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005751
   Taylor GJ, 2000, CAN J PSYCHIAT, V45, P134
   Tortella-Feliu M, 2010, J ANXIETY DISORD, V24, P686, DOI 10.1016/j.janxdis.2010.04.012
   Treede RD, 1999, PAIN, V79, P105, DOI 10.1016/S0304-3959(98)00184-5
   van Dijke A, 2010, J TRAUMA DISSOCIATIO, V11, P424, DOI 10.1080/15299732.2010.496140
   van Wingen GA, 2011, PSYCHOL MED, V41, P1397, DOI 10.1017/S0033291710002084
   Walker S, 2011, COGN AFFECT BEHAV NE, V11, P463, DOI 10.3758/s13415-011-0042-1
   Waller E, 2006, INT REV PSYCHIATR, V18, P13, DOI 10.1080/09540260500466774
   Waller E, 2004, J PSYCHOSOM RES, V57, P239, DOI 10.1016/S0022-3999(03)00613-5
   Weizmann-Henelius G, 2004, PSYCHOPATHOLOGY, V37, P213, DOI 10.1159/000080716
   Wilbertz G, 2010, J AFFECT DISORDERS, V124, P262, DOI 10.1016/j.jad.2009.11.021
   Williams C, 2010, J CLIN EXP NEUROPSYC, V32, P259, DOI 10.1080/13803390902976940
   Xu XJ, 2009, J NEUROSCI, V29, P8525, DOI 10.1523/JNEUROSCI.2418-09.2009
   Yang CY, 2009, BRAIN RES, V1251, P176, DOI 10.1016/j.brainres.2008.11.062
NR 157
TC 0
Z9 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1016-6262
J9 VERHALTENSTHERAPIE
JI Verhaltenstherapie
PY 2013
VL 23
IS 1
BP 23
EP 34
DI 10.1159/000346611
PG 12
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 137YZ
UT WOS:000318475900004
ER

PT J
AU Frick, LR
   Williams, K
   Pittenger, C
AF Frick, Luciana Romina
   Williams, Kyle
   Pittenger, Christopher
TI Microglial Dysregulation in Psychiatric Disease
SO CLINICAL & DEVELOPMENTAL IMMUNOLOGY
LA English
DT Review
ID DORSOLATERAL PREFRONTAL CORTEX; REGULATORY T-CELLS; AUTISM SPECTRUM
   DISORDERS; NITRIC-OXIDE PRODUCTION; RETT-SYNDROME; INTERFERON-GAMMA;
   CHRONIC-SCHIZOPHRENICS; ANIMAL-MODEL; IN-VITRO; HIPPOCAMPAL NEUROGENESIS
AB Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including synaptic pruning during development and the support of adult neurogenesis. Microglial abnormalities have been found in several neuropsychiatric conditions, though in most cases it remains unclear whether these are causative or are a reaction to some other underlying pathophysiology. Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome. We identify gaps in the existing literature and important areas for future research. If microglial pathology proves to be an important causative factor in these or other neuropsychiatric diseases, modulators of microglial function may represent a novel therapeutic strategy.
C1 [Frick, Luciana Romina; Williams, Kyle; Pittenger, Christopher] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 USA.
   [Williams, Kyle; Pittenger, Christopher] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06519 USA.
   [Pittenger, Christopher] Yale Univ, Sch Med, Dept Psychol, New Haven, CT 06519 USA.
RP Pittenger, C (reprint author), Yale Univ, Sch Med, Dept Psychiat, 34 Pk St,W315, New Haven, CT 06519 USA.
EM christopher.pittenger@yale.edu
CR Anderson G, 2013, PROG NEURO-PSYCHOPH, V42, P5, DOI 10.1016/j.pnpbp.2012.06.014
   Arakawa S., 2011, PHARM BIOCH BEHAV, V100, P601
   Avidan H, 2004, EUR J IMMUNOL, V34, P3434, DOI 10.1002/eji.200424883
   Bachstetter AD, 2011, NEUROBIOL AGING, V32, P2030, DOI 10.1016/j.neurobiolaging.2009.11.022
   Bayer TA, 1999, NEUROSCI LETT, V271, P126, DOI 10.1016/S0304-3940(99)00545-5
   Bhattacharyya S, 2009, NEUROPSYCHOPHARMACOL, V34, P2489, DOI 10.1038/npp.2009.77
   Bian Q, 2008, PROG NEURO-PSYCHOPH, V32, P42, DOI 10.1016/j.pnpbp.2007.06.031
   Bilbo SD, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.014.2009
   Blaylock RL, 2009, CURR MED CHEM, V16, P157
   Blue ME, 1999, EXP NEUROL, V156, P345, DOI 10.1006/exnr.1999.7030
   Busse S, 2012, BRAIN BEHAV IMMUN, V26, P1273, DOI 10.1016/j.bbi.2012.08.005
   Butovsky O, 2005, MOL CELL NEUROSCI, V29, P381, DOI 10.1016/j.mcn.2005.03.005
   Chang Y, 2009, MEDIAT INFLAMM, DOI 10.1155/2009/705379
   Chaudhry B., 2012, J PSYCHOPHARMACOL, V26, P1185
   Chaves C, 2010, PROG NEURO-PSYCHOPH, V34, P550, DOI 10.1016/j.pnpbp.2010.01.020
   Chen SK, 2010, CELL, V141, P775, DOI 10.1016/j.cell.2010.03.055
   Chung HS, 2012, NEUROCHEM RES, V37, P2117, DOI 10.1007/s11064-012-0833-y
   Connors SL, 2005, J CHILD NEUROL, V20, P876, DOI 10.1177/08830738050200110401
   Corona A. W., 2012, BRAIN BEHAV IMMUNITY
   Corona AW, 2010, J NEUROINFLAMM, V7, DOI 10.1186/1742-2094-7-93
   Coyle J.T., 2012, HDB EXP PHARM, V213, P267, DOI DOI 10.1007/978-3-642-25758-2_10
   Czeh M, 2011, DEV NEUROSCI-BASEL, V33, P199, DOI 10.1159/000328989
   Dantzer R, 2009, IMMUNOL ALLERGY CLIN, V29, P247, DOI 10.1016/j.iac.2009.02.002
   Dean B., 2012, MOL PSYCHIAT
   Derecki NC, 2012, NATURE, V484, P105, DOI 10.1038/nature10907
   Doorduin J, 2009, J NUCL MED, V50, P1801, DOI 10.2967/jnumed.109.066647
   Drexhage RC, 2011, INT J NEUROPSYCHOPH, V14, P746, DOI 10.1017/S1461145710001653
   Duman RS, 2012, SCIENCE, V338, P68, DOI 10.1126/science.1222939
   Eyre H, 2012, PSYCHONEUROENDOCRINO, V37, P1397, DOI 10.1016/j.psyneuen.2012.03.019
   Fillman SG, 2013, MOL PSYCHIATR, V18, P206, DOI 10.1038/mp.2012.110
   Greer JM, 2002, NEURON, V33, P23, DOI 10.1016/S0896-6273(01)00564-5
   Guillemin GJ, 2012, FEBS J, V279, P1356, DOI 10.1111/j.1742-4658.2012.08485.x
   Hagberg H, 2012, ANN NEUROL, V71, P444, DOI 10.1002/ana.22620
   Hashimoto K, 2009, BRAIN RES REV, V61, P105, DOI 10.1016/j.brainresrev.2009.05.005
   Hashioka S, 2007, EXP NEUROL, V206, P33, DOI 10.1016/j.expneurol.2007.03.022
   Heo Y, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020912
   Hinojosa AE, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-77
   Hinwood M, 2012, CEREB CORTEX, V22, P1442, DOI 10.1093/cercor/bhr229
   Holstege JC, 2008, P NATL ACAD SCI USA, V105, P6338, DOI 10.1073/pnas.0802176105
   Horikawa H, 2010, PROG NEURO-PSYCHOPH, V34, P1306, DOI 10.1016/j.pnpbp.2010.07.015
   Horska A, 2009, ANN NEUROL, V65, P90, DOI 10.1002/ana.21562
   Hou Y, 2006, PROG NEURO-PSYCHOPH, V30, P1523, DOI 10.1016/j.pnpbp.2006.05.006
   Huber L, 2012, DEV BIOL, V363, P219, DOI 10.1016/j.ydbio.2011.12.026
   Ji K, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056293
   Juckel G, 2011, SCHIZOPHR RES, V131, P96, DOI 10.1016/j.schres.2011.06.018
   Kato T, 2008, J NEUROCHEM, V106, P815, DOI 10.1111/j.1471-4159.2008.05435.x
   Kato T, 2007, SCHIZOPHR RES, V92, P108, DOI 10.1016/j.schres.2007.01.019
   Kato TA, 2011, SCHIZOPHR RES, V129, P172, DOI 10.1016/j.schres.2011.03.019
   Kelly DL, 2011, SCHIZOPHR RES, V133, P257, DOI 10.1016/j.schres.2011.08.005
   Kettenmann H, 2011, PHYSIOL REV, V91, P461, DOI 10.1152/physrev.00011.2010
   Kipnis J, 2005, NEUROMOL MED, V7, P197, DOI 10.1385/NMM:7:3:197
   Knoepfler PS, 2001, ONCOGENE, V20, P5440, DOI 10.1038/sj.onc.1204710
   Levkovitz Y, 2010, J CLIN PSYCHIAT, V71, P138, DOI 10.4088/JCP.08m04666yel
   Wierzba-Bobrowicz T, 2005, FOLIA NEUROPATHOL, V43, P81
   Liaury K, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-56
   Liu DX, 2011, NEUROPHARMACOLOGY, V61, P592, DOI 10.1016/j.neuropharm.2011.04.033
   Liu JU, 2009, J IMMUNOL, V182, P3855, DOI 10.4049/jimmunol.0803330
   MacFabe DF, 2007, BEHAV BRAIN RES, V176, P149, DOI 10.1016/j.bbr.2006.07.025
   MacFabe DF, 2011, BEHAV BRAIN RES, V217, P47, DOI 10.1016/j.bbr.2010.10.005
   Maes Michael, 2012, Inflammopharmacology, V20, P127, DOI 10.1007/s10787-011-0111-7
   Maezawa I, 2010, J NEUROSCI, V30, P5346, DOI 10.1523/JNEUROSCI.5966-09.2010
   Maiorino C., 2012, GENE THERAPY
   Mathews DC, 2012, DRUGS, V72, P1313, DOI 10.2165/11633130-000000000-00000
   Miyaoka T, 2012, PROG NEURO-PSYCHOPH, V37, P222, DOI 10.1016/j.pnpbp.2012.02.002
   Miyaoka T, 2008, CLIN NEUROPHARMACOL, V31, P287, DOI [10.1097/WNF.0b013e3181593d45, 10.1097/wnf.0b013e3181593d45]
   Miyaoka T, 2007, PROG NEURO-PSYCHOPH, V31, P304, DOI 10.1016/j.pnpbp.2006.08.013
   Mizutani M, 2012, J IMMUNOL, V188, P29, DOI 10.4049/jimmunol.1100421
   Morer A, 2010, BRAIN BEHAV IMMUN, V24, P1069, DOI 10.1016/j.bbi.2010.02.007
   Morgan JT, 2012, BRAIN RES, V1456, P72, DOI 10.1016/j.brainres.2012.03.036
   Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
   Nimmerjahn A, 2005, SCIENCE, V308, P1314, DOI 10.1126/science.1110647
   Obuchowicz E, 2006, INT J NEUROPSYCHOPH, V9, P27, DOI 10.1017/S146114570500547X
   Paolicelli RC, 2011, SCIENCE, V333, P1456, DOI 10.1126/science.1202529
   Pittenger C, 2008, NEUROPSYCHOPHARMACOL, V33, P88, DOI 10.1038/sj.npp.1301574
   Prinz M, 2010, J NEUROIMMUNOL, V224, P80, DOI 10.1016/j.jneuroim.2010.05.015
   Radewicz K, 2000, J NEUROPATH EXP NEUR, V59, P137
   Ratnayake U, 2012, BRAIN BEHAV IMMUN, V26, P1288, DOI 10.1016/j.bbi.2012.08.011
   Reynolds AD, 2007, J LEUKOCYTE BIOL, V82, P1083, DOI 10.1189/jlb.0507296
   Rogers JT, 2011, J NEUROSCI, V31, P16241, DOI 10.1523/JNEUROSCI.3667-11.2011
   Rosas M, 2011, EUR J IMMUNOL, V41, P356, DOI 10.1002/eji.201040962
   Saederup N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013693
   Sanacora G, 2012, NEUROPHARMACOLOGY, V62, P63, DOI 10.1016/j.neuropharm.2011.07.036
   Sargin D, 2009, GLIA, V57, P693, DOI 10.1002/glia.20797
   Schafer DP, 2012, NEURON, V74, P691, DOI 10.1016/j.neuron.2012.03.026
   Seshadri S, 2010, P NATL ACAD SCI USA, V107, P5622, DOI 10.1073/pnas.0909284107
   Sierra A, 2010, CELL STEM CELL, V7, P483, DOI 10.1016/j.stem.2010.08.014
   Sominsky L, 2012, BEHAV BRAIN RES, V226, P351, DOI 10.1016/j.bbr.2011.08.038
   Steiner J, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-94
   Steiner J, 2008, J PSYCHIATR RES, V42, P151, DOI 10.1016/j.jpsychires.2006.10.013
   Steiner J, 2006, ACTA NEUROPATHOL, V112, P305, DOI 10.1007/s00401-006-0090-8
   Stence N, 2001, GLIA, V33, P256, DOI 10.1002/1098-1136(200103)33:3<256::AID-GLIA1024>3.3.CO;2-A
   Suzuki K, 2013, JAMA PSYCHIAT, V70, P49, DOI 10.1001/jamapsychiatry.2013.272
   Swedo S. E., NEUROLOGY, V74, P1397
   Tetreault NA, 2012, J AUTISM DEV DISORD, V42, P2569, DOI 10.1007/s10803-012-1513-0
   Togo T, 2000, BRAIN RES, V885, P117, DOI 10.1016/S0006-8993(00)02984-X
   Trenblay M. E., 2011, J NEUROSCI, V31, P16064
   Tynan RJ, 2012, BRAIN BEHAV IMMUN, V26, P469, DOI 10.1016/j.bbi.2011.12.011
   Udina M, 2012, J CLIN PSYCHIAT, V73, P1128, DOI 10.4088/JCP.12r07694
   Uranova NA, 2010, WORLD J BIOL PSYCHIA, V11, P567, DOI 10.3109/15622970903414188
   van Berckel BN, 2008, BIOL PSYCHIAT, V64, P820, DOI 10.1016/j.biopsych.2008.04.025
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Wang GG, 2006, NAT METHODS, V3, P287, DOI 10.1038/NMETH865
   Wang KC, 2013, NEUROSCIENCE, V234, P146, DOI 10.1016/j.neuroscience.2012.12.049
   Wierzba-Bobrowicz T, 2004, FOLIA NEUROPATHOL, V42, P157
   Wohleb ES, 2011, J NEUROSCI, V31, P6277, DOI 10.1523/JNEUROSCI.0450-11.2011
   Wohleb ES, 2012, PSYCHONEUROENDOCRINO, V37, P1491, DOI 10.1016/j.psyneuen.2012.02.003
   Wood L, 2010, NEUROBIOL DIS, V38, P281, DOI 10.1016/j.nbd.2010.01.018
   Yang GA, 2011, BRAIN PATHOL, V21, P279, DOI 10.1111/j.1750-3639.2010.00445.x
   Zerrate MC, 2007, J PHARMACOL EXP THER, V322, P16, DOI 10.1124/jpet.107.121483
   Zhang F., 2012, PARKINSONISM RELA S1, V18, P213
   Zheng LT, 2008, J NEUROCHEM, V107, P1225, DOI 10.1111/j.1471-4159.2008.05675.x
   Zhou XL, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-210
NR 112
TC 17
Z9 17
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1740-2522
J9 CLIN DEV IMMUNOL
JI Clin. Dev. Immunol.
PY 2013
AR 608654
DI 10.1155/2013/608654
PG 10
WC Immunology
SC Immunology
GA 132OB
UT WOS:000318077300001
ER

PT J
AU Tete, S
   Varvara, G
   Murmura, G
   Saggini, A
   Maccauro, G
   Rosati, M
   Cianchetti, E
   Tripodi, D
   Toniato, E
   Fulcheri, M
   Caraffa, A
   Antinolfi, P
   Pandolfi, F
   Potalivo, G
   Conti, P
   Theoharides, TC
AF Tete, S.
   Varvara, G.
   Murmura, G.
   Saggini, A.
   Maccauro, G.
   Rosati, M.
   Cianchetti, E.
   Tripodi, D.
   Toniato, E.
   Fulcheri, M.
   Caraffa, A.
   Antinolfi, P.
   Pandolfi, F.
   Potalivo, G.
   Conti, P.
   Theoharides, T. C.
TI IMPACT OF IMMUNITY IN AUTISM SPECTRUM DISORDERS
SO EUROPEAN JOURNAL OF INFLAMMATION
LA English
DT Editorial Material
DE autism spectrum disorders; cytokines; inflammation; immunity
ID CORTICOTROPIN-RELEASING HORMONE; BLOOD MONONUCLEAR-CELLS;
   NECROSIS-FACTOR-ALPHA; MESSENGER-RNA EXPRESSION; PERIPHERAL-BLOOD;
   MAST-CELLS; T-CELLS; SYSTEMIC-SCLEROSIS; IN-VITRO; INFLAMMATORY RESPONSE
AB Autism spectrum disorders (ASDs) are childhood psychopathologies characterized by having difficulties in social interaction, verbal and non-verbal communication as well as sensor motor movements. Evidence suggests that in ASDs environmental toxicant exposure, genetic and mitochondrial dysfunction are involved associated with abnormal immune response with allergic problems and elevated serum IgE. ASDs present the major cytokine and chemokine dysfunction in CNS and is mediated by an increase of pro-inflammatory cytokine levels in the brain, such as TNF, IL-I, IFN-gamma, IL-6, IL-8 and others. Mast cells, which are also implicated in ASDs, are worsened by stress and produce proinflammatory cytokines and can be stimulated by neurotensin in the brain and gut, contributing also to the inflammatory response. However, the exact etiology of ASDs remains largely unknown.
C1 [Tete, S.; Varvara, G.; Murmura, G.; Tripodi, D.] Univ Chiet Pescarai, Sch Dent, Chieti, Italy.
   [Saggini, A.] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy.
   [Maccauro, G.] Univ Cattolica, Orthoped Div, Rome, Italy.
   [Rosati, M.] Osped Pescara, Gynecol Div, Pescara, Italy.
   [Cianchetti, E.] Ortona ASL Hosp, Dept Surg, Ortona, Italy.
   [Toniato, E.; Conti, P.] Univ G dAnnunzio, Sch Med, Div Immunol, Chieti, Italy.
   [Fulcheri, M.] Univ G dAnnunzio, Sch Psychol, Chieti, Italy.
   [Caraffa, A.; Antinolfi, P.; Potalivo, G.] Univ Perugia, Orthopead Div, I-06100 Perugia, Italy.
   [Pandolfi, F.] Univ Cattolica Sacro Cuore, Dept Med, Rome, Italy.
   [Theoharides, T. C.] Tufts Univ, Sch Med, Dept Mol Physiol & Pharmacol, Mol Immunopharmacol & Drug Discovery Lab, Boston, MA 02111 USA.
   [Theoharides, T. C.] Tufts Univ New England Med Ctr, Drug Discovery Lab, Boston, MA 02111 USA.
RP Tete, S (reprint author), Univ G dAnnunzio, Dipartimento Sci Orali, Via Vestini 31, Chieti, Italy.
EM tete@unich.it
CR Abbott NJ, 2000, CELL MOL NEUROBIOL, V20, P131, DOI 10.1023/A:1007074420772
   Aguerri M, 2012, EUR J INFLAMM, V10, P193
   Almerigogna F, 2011, INT J IMMUNOPATH PH, V24, P231
   Angelini A, 2011, J BIOL REG HOMEOS AG, V25, P203
   ANGIONI S, 1993, LIFE SCI, V53, P1735, DOI 10.1016/0024-3205(93)90160-5
   Armogida M, 2011, INT J IMMUNOPATH PH, V24, P735
   Battelli MG, 2011, J BIOL REG HOMEOS AG, V25, P77
   Bauer M, 2008, J NEUROCHEM, V104, P1101, DOI 10.1111/j.1471-4159,2007.05037.x
   Bekenstein U, 2012, MOL CELL NEUROSCI, pS1044
   Bellisai F, 2011, INT J IMMUNOPATH PH, V24, P261
   Benucci M, 2011, INT J IMMUNOPATH PH, V24, P269
   Brunetti L, 2012, J BIOL REG HOMEOS AG, V26, P295
   Caimmi S, 2011, INT J IMMUNOPATH PH, V24, P517
   Caporale CM, 2011, INT J IMMUNOPATH PH, V24, P175
   Carlesimo M, 2012, EUR J INFLAMM, V10, P535
   Carlesimo M, 2012, EUR J INFLAMM, V10, P247
   CARRAWAY R, 1982, J PHYSIOL-LONDON, V323, P403
   Cassano N, 2011, J BIOL REG HOMEOS AG, V25, P285
   Castagliuolo I, 1996, P NATL ACAD SCI USA, V93, P12611, DOI 10.1073/pnas.93.22.12611
   Catanzaro R, 2012, J BIOL REG HOMEOS AG, V26, P337
   Cazzato IA, 2011, INT J IMMUNOPATH PH, V24, P535
   Chiricozzi A, 2012, J BIOL REG HOMEOS AG, V26, P313
   Chiricozzi A, 2012, J BIOL REG HOMEOS AG, V26, P165
   Cianci R, 2012, J BIOL REG HOMEOS AG, V26, P171
   Ciprandi G, 2011, J BIOL REG HOMEOS AG, V25, P295
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Dardeno TA, 2010, FRONT NEUROENDOCRIN, V31, P377, DOI 10.1016/j.yfrne.2010.06.002
   Devirgiliis V, 2011, INT J IMMUNOPATH PH, V24, P793
   Dianzani C, 2011, INT J IMMUNOPATH PH, V24, P523
   di Giannantonio M, 2011, J BIOL REG HOMEOS AG, V25, P109
   El-Hashim AZ, 2011, INT J IMMUNOPATH PH, V24, P33
   Eusebio M, 2012, J BIOL REG HOMEOS AG, V26, P211
   GADIENT RA, 1994, NEUROSCI LETT, V182, P243, DOI 10.1016/0304-3940(94)90807-9
   Galliera E, 2011, J BIOL REG HOMEOS AG, V25, P85
   Garzaro M, 2011, J BIOL REG HOMEOS AG, V25, P101
   Giganti MG, 2011, J BIOL REG HOMEOS AG, V25, P291
   Graham MR, 2011, INT J IMMUNOPATH PH, V24, P119
   Hatzistilianou M, 2011, INT J IMMUNOPATH PH, V24, P25
   Hauguel-de MS, 2006, AM J OBSTET GYNECOL, V194, P1537
   Iezzi M, 2011, INT J IMMUNOPATH PH, V24, P621
   Karalis K, 1997, PEPTIDES, V71, P131
   Kauffman MA, 2011, INT J IMMUNOPATH PH, V24, P499
   Kempuraj D, 2004, ENDOCRINOLOGY, V145, P43, DOI 10.1210/en.2003-0805
   Kern JK, 2012, ACTA NEUROBIOL EXP, V72, P113
   Li XF, 2011, INT J IMMUNOPATH PH, V24, P631
   Lin WY, 2012, J BIOL REG HOMEOS AG, V26, P401
   Makrigiannakis A, 2007, INT J GYNECOL OBSTET, V97, P115, DOI 10.1016/j.ijgo.2007.01.007
   Mancuso RA, 2004, PSYCHOSOM MED, V66, P762, DOI 10.1097/01.psy.0000138284.70670.d5
   Marotta F, 2012, J BIOL REG HOMEOS AG, V26, P327
   Marotta F, 2012, J BIOL REG HOMEOS AG, V26, P285
   Marotta F, 2011, J BIOL REG HOMEOS AG, V25, P221
   Martinotti G, 2012, J BIOL REG HOMEOS AG, V26, P347
   Mazzoccoli G, 2011, INT J IMMUNOPATH PH, V24, P201
   Mazzoccoli G, 2011, J BIOL REG HOMEOS AG, V25, P231
   Mazzucchelli R, 2011, INT J IMMUNOPATH PH, V24, P489
   Mazzucchelli R, 2012, J BIOL REG HOMEOS AG, V26, P181
   Molloy CA, 2006, J NEUROIMMUNOL, V172, P198, DOI 10.1016/j.jneuroim.2005.11.007
   Naruishi K, 2011, J BIOL REG HOMEOS AG, V25, P195
   Orciani M, 2011, J BIOL REG HOMEOS AG, V25, P115
   Pantalone A, 2011, INT J IMMUNOPATH PH, V24, P519
   Park JA, 2011, INT J IMMUNOPATH PH, V24, P505
   Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
   PETRAGLIA F, 1990, AM J OBSTET GYNECOL, V163, P1307
   Pizzi M, 2011, INT J IMMUNOPATH PH, V24, P539
   Pizzicannella J, 2011, J BIOL REG HOMEOS AG, V25, P93
   Prada J, 2012, EUR J INFLAMM, V10, P527
   Prus E, 2012, J BIOL REG HOMEOS AG, V26, P203
   Quintero P, 2012, J BIOL REG HOMEOS AG, V26, P379
   Racciatti D, 2011, INT J IMMUNOPATH PH, V24, P673
   Rapin I, 1997, NEW ENGL J MED, V337, P97, DOI 10.1056/NEJM199707103370206
   Ricci G, 2011, INT J IMMUNOPATH PH, V24, P721
   Rivetti S, 2011, INT J IMMUNOPATH PH, V24, P639
   Rosato E, 2011, INT J IMMUNOPATH PH, V24, P727
   Saggini A, 2011, INT J IMMUNOPATH PH, V24, P509
   Schumann J, 2012, J BIOL REG HOMEOS AG, V26, P357
   Sedriep S, 2011, J BIOL REG HOMEOS AG, V25, P187
   Shimizu Y, 2011, J BIOL REG HOMEOS AG, V25, P177
   Angelidou A, 2010, J NEUROINFLAMM, V7, DOI 10.1186/1742-2094-7-48
   Singh LK, 1999, BRAIN BEHAV IMMUN, V13, P225, DOI 10.1006/brbi.1998.0541
   Sismanopoulos N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033271
   SKOFITSCH G, 1985, PEPTIDES, V6, P307, DOI 10.1016/0196-9781(85)90057-9
   Slominski A, 2006, FRONT BIOSCI-LANDMRK, V11, P2230, DOI 10.2741/1966
   Slominski A, 2001, FASEB J, V15, P1678, DOI 10.1096/fj.00-0850rev
   Suzuki K, 2011, INT J IMMUNOPATH PH, V24, P7
   Taildeman J, 2009, HISTOCHEM CELL BIOL, V131, P703, DOI 10.1007/s00418-009-0575-3
   Tarakanov I, 2011, J BIOL REG HOMEOS AG, V25, P169
   Theoharides TC, 1998, ENDOCRINOLOGY, V139, P403, DOI 10.1210/en.139.1.403
   Theoharides TC, 2007, FRONT BIOSCI, V12, P1615, DOI 10.2741/2174
   Theoharides TC, 2004, J NEUROIMMUNOL, V146, P1, DOI 10.1016/j.jneuroim.2003.10.041
   Vignini A, 2011, INT J IMMUNOPATH PH, V24, P529
   Vikman K, 1998, J NEUROCYTOL, V27, P749, DOI 10.1023/A:1006903002044
   Wang J, 2012, NEUROTOXICOL TERATOL, P00179
   Wang JC, 2011, INT J IMMUNOPATH PH, V24, P595
   Wu KG, 2011, INT J IMMUNOPATH PH, V24, P15
   Zhang J, 2012, EUR J INFLAMM, V10, P25
   Zizzi A, 2011, INT J IMMUNOPATH PH, V24, P557
NR 96
TC 1
Z9 1
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 1721-727X
J9 EUR J INFLAMM
JI Eur. J. Inflamm.
PD JAN-APR
PY 2013
VL 11
IS 1
BP 23
EP 31
PG 9
WC Immunology
SC Immunology
GA 133GY
UT WOS:000318128100003
ER

PT J
AU Yammamoto, H
   Tanaka, S
   Tanaka, A
   Hide, I
   Seki, T
   Sakai, N
AF Yammamoto, Hikaru
   Tanaka, Shigeru
   Tanaka, Anna
   Hide, Izumi
   Seki, Takahiro
   Sakai, Norio
TI Long-Term Exposure of RN46A Cells Expressing Serotonin Transporter
   (SERT) to a cAMP Analog Up-regulates SERT Activity and Is Accompanied by
   Neural Differentiation of the Cells
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE serotonin transporter; cyclic AMP; membrane trafficking; neural
   differentiation
ID PROTEIN-COUPLED RECEPTORS; KINASE-C-GAMMA; CYCLIC-AMP; SURFACE
   EXPRESSION; RAT-BRAIN; PHOSPHORYLATION; ACTIVATION; AUTISM; TRAFFICKING;
   BEHAVIOR
AB To examine the functional regulation of serotonin transporter (SERT) by cAMP, we examined whether SERT uptake activity was affected by dibutyryl cAMP (dbcAMP), a cAMP analog, in SERT-transfected RN46A cells derived from embryonic rat raphe neurons. Long-term exposure (>4 h) of dbcAMP (1 mM) to SERT-expressing RN46A cells significantly up-regulated SERT activity. In addition, a selective PKA activator, but not a selective EPAC activator, increased the serotonin uptake activity of SERT, suggesting that this regulation was mainly mediated via PKA. Time-dependent up-regulation of SERT activity by dbcAMP was accompanied by neural differentiation of RN46A cells. Further investigation of dbcAMP-induced up-regulation of SERT revealed that dbcAMP elevated SERT protein levels without affecting SERT mRNA transcription. The chase assay for residual SERT protein revealed that dbcAMP slowed its degradation rate. Immunohistochemical analysis revealed that plasma membrane-localized SERT was more abundant in dbcAMP-treated cells than in non-treated cells, suggesting that dbcAMP up-regulated SERT by decreasing its degradation and increasing its plasma membrane expression. These results raise the possibility that the elevation of intracellular cAMP up-regulated SERT function through a mechanism linked to the differentiation of RN46A cells and show the importance of SERT function during the developmental process of the serotonergic nervous system.
C1 [Yammamoto, Hikaru; Tanaka, Shigeru; Tanaka, Anna; Hide, Izumi; Seki, Takahiro; Sakai, Norio] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Mol & Pharmacol Neurosci, Minami Ku, Hiroshima 7348551, Japan.
RP Sakai, N (reprint author), Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Mol & Pharmacol Neurosci, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM nsakai@hiroshima-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology; Takeda
   Science Foundation; Uehara Memorial Foundation; Naito Foundation;
   Suzuken Memorial Foundation; Tokyo Biochemical Research Foundation;
   Japanese Smoking Research Association
FX This study was supported by a Grant-in-Aid for Scientific Research from
   the Ministry of Education, Culture, Sports, Science and Technology and
   by grants from the Takeda Science Foundation, Uehara Memorial
   Foundation, Naito Foundation, Suzuken Memorial Foundation, Tokyo
   Biochemical Research Foundation, and Japanese Smoking Research
   Association. This work was carried out using equipment at the Analysis
   Center of Life Science and Research Institute for Radiation Biology and
   Medicine, Hiroshima University.
CR Anderson G., 1990, ANN NY ACAD SCI, V660, P331
   Blakely RD, 1998, BIOL PSYCHIAT, V44, P169, DOI 10.1016/S0006-3223(98)00124-3
   BLAKELY RD, 1991, NATURE, V354, P66, DOI 10.1038/354066a0
   Cai D, 2001, J NEUROSCI, V21, P4731
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Chugani DC, 1997, ANN NEUROL, V42, P666, DOI 10.1002/ana.410420420
   Dai Y, 2008, J PHARMACOL EXP THER, V326, P153, DOI 10.1124/jpet.107.135046
   de Rooij J, 1998, NATURE, V396, P474
   EATON MJ, 1995, DEV BIOL, V170, P169, DOI 10.1006/dbio.1995.1205
   Gloerich M, 2010, ANNU REV PHARMACOL, V50, P355, DOI 10.1146/annurev.pharmtox.010909.105714
   Han Dawn D., 2006, BMC Pharmacology, V6, P6, DOI 10.1186/1471-2210-6-6
   Hendricks TJ, 2003, NEURON, V37, P233, DOI 10.1016/S0896-6273(02)01167-4
   Kajimoto T, 2004, J BIOL CHEM, V279, P12668, DOI 10.1074/jbc.M312350200
   Kawasaki H, 1998, SCIENCE, V282, P2275, DOI 10.1126/science.282.5397.2275
   KUHAR MJ, 1972, J PHARMACOL-PARIS, V181, P36
   Lesch KP, 1996, SCIENCE, V274, P1527, DOI 10.1126/science.274.5292.1527
   Miyazaki K, 2005, INT J DEV NEUROSCI, V23, P287, DOI 10.1016/j.ijdevneu.2004.05.004
   Mochizuki H, 2005, NEUROCHEM INT, V46, P93, DOI 10.1016/j.neuint.2004.08.008
   Morikawa O, 1998, EUR J PHARMACOL, V349, P317, DOI 10.1016/S0014-2999(98)00187-3
   Mouri A, 2012, J NEUROSCI, V32, P4562, DOI 10.1523/JNEUROSCI.6458-11.2012
   Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024
   Nobukuni M, 2009, J PHARMACOL SCI, V111, P392, DOI 10.1254/jphs.09195FP
   Olivier B, 2000, Prog Drug Res, V54, P59
   Ozaki N, 2003, MOL PSYCHIATR, V8, P933, DOI 10.1038/sj.mp.4001365
   Peace AG, 2011, BRAIN RES BULL, V84, P280, DOI 10.1016/j.brainresbull.2010.09.002
   Prasad HC, 2009, PHILOS T R SOC B, V364, P163, DOI 10.1098/rstb.2008.0143
   Qian Y, 1997, J NEUROSCI, V17, P45
   Ramamoorthy S, 1999, SCIENCE, V285, P763, DOI 10.1126/science.285.5428.763
   Ramamoorthy S, 1998, J BIOL CHEM, V273, P2458, DOI 10.1074/jbc.273.4.2458
   RUDNICK G, 1991, MOL PHARMACOL, V40, P421
   Sakai N, 1997, J NEUROCHEM, V68, P2618
   Samuvel DJ, 2005, J NEUROSCI, V25, P29, DOI 10.1523/JNEUROSCI.3754-04.2005
   Seki T, 2005, J BIOL CHEM, V280, P29096, DOI 10.1074/jbc.M501716200
   Seki T, 2009, NEUROBIOL DIS, V33, P260, DOI 10.1016/j.nbd.2008.10.013
   Stahl SM, 2000, ESSENTIAL PSYCHOPHAR
   Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648
   Tamada K, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015126
   Tanaka S, 2007, J BIOL CHEM, V282, P10506, DOI 10.1074/jbc.M700911200
   Uhlenbrock K, 2002, CELL SIGNAL, V14, P941, DOI 10.1016/S0898-6568(02)00041-4
   Vaughan RA, 2004, J PHARMACOL EXP THER, V310, P1, DOI 10.1124/jpet.103.052423
   Walther DJ, 2003, CELL, V115, P851, DOI 10.1016/S0092-8674(03)01014-6
   Walther DJ, 2011, FEBS J, V278, P4740, DOI 10.1111/j.1742-4658.2011.08347.x
   Watts SW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005682
   WHITE LA, 1994, J NEUROSCI, V14, P6744
   Yamamoto H, 1998, NEUROSCI RES, V32, P305, DOI 10.1016/S0168-0102(98)00097-2
   Yamamoto K, 2010, GENES CELLS, V15, P425, DOI 10.1111/j.1365-2443.2010.01395.x
   Zhu CB, 2004, MOL PHARMACOL, V65, P1462, DOI 10.1124/mol.65.6.1462
NR 47
TC 4
Z9 4
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD JAN
PY 2013
VL 121
IS 1
BP 25
EP 38
DI 10.1254/jphs.12229FP
PG 14
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 134HD
UT WOS:000318200100004
PM 23269237
ER

PT J
AU Occelli, V
   Esposito, G
   Venuti, P
   Arduino, GM
   Zampini, M
AF Occelli, Valeria
   Esposito, Gianluca
   Venuti, Paola
   Arduino, Giuseppe Maurizio
   Zampini, Massimiliano
TI The takete-maluma phenomenon in autism spectrum disorders
SO PERCEPTION
LA English
DT Article
DE autism spectrum disorders; crossmodal correspondences; pseudosynesthetic
   correspondences; sound symbolism; takete-maluma
ID SPEEDED CLASSIFICATION; PHONETIC SYMBOLISM; SOUND SYMBOLISM; PERCEPTION;
   SIZE; DISCRIMINATION; DIMENSIONS; SIMILARITY; CORRESPONDENCES;
   CATEGORIZATION
AB It has been reported that people tend to preferentially associate phonemes like /m/, /l/, /n/ to curvilinear shapes and phonemes like /t/, /z/, /r/, /k/ to rectilinear shapes. Here we evaluated the performance of children/adolescents with autism spectrum disorders (ASD) and neurotypical controls in this audiovisual congruency phenomenon. Pairs of visual patterns (curvilinear vs rectilinear) were presented to a group of ASD participants (low- or high-functioning) and a group of age-matched neurotypical controls. Participants were asked to associate each item to non-meaningful phoneme clusters. ASD participants showed a lower proportion of expected association responses than the controls. Within the ASD group the performance varied as a function of the severity of the symptomatology. These data suggest that children/adolescents with ASD show, although at different degrees as a function of the severity of the ASD, lower phonetic-iconic congruency response patterns than neurotypical controls, pointing to poorer multisensory integration capabilities.
C1 [Occelli, Valeria; Esposito, Gianluca; Venuti, Paola; Zampini, Massimiliano] Univ Trent, Dept Psychol & Cognit Sci, Rovereto, TN, Italy.
   [Esposito, Gianluca] RIKEN Brain Sci Inst, Kuroda Res Unit Affiliat Social Behav, Wako, Saitama, Japan.
   [Arduino, Giuseppe Maurizio] Ctr Autism & Asperger Syndrome, Mondovi, Italy.
   [Zampini, Massimiliano] Univ Trent, Ctr Mind Brain Sci, CIMeC, Rovereto, TN, Italy.
RP Occelli, V (reprint author), Emory Univ, Sch Med, Dept Neurol, Woodruff Mem Res Bldg,Suite 6209,101 Woodruff Cir, Atlanta, GA 30322 USA.
EM valeria.occelli@gmail.com
RI Esposito, Gianluca/B-1374-2012; Esposito, Gianluca/K-9353-2013
OI Esposito, Gianluca/0000-0002-9442-0254; Esposito,
   Gianluca/0000-0002-9442-0254
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Aveyard ME, 2012, MEM COGNITION, V40, P83, DOI 10.3758/s13421-011-0139-3
   Bebko JM, 2006, J CHILD PSYCHOL PSYC, V47, P88, DOI 10.1111/j.1469-7610.2005.01443.x
   BENARTZI E, 1995, PERCEPT PSYCHOPHYS, V57, P1151, DOI 10.3758/BF03208371
   Church BA, 2010, PSYCHON B REV, V17, P862, DOI [10.3758/PBR.17.6.862, 10.3738/PBR.17.6.862]
   CIESIELSKI KT, 1995, NEUROPSYCHOLOGIA, V33, P225, DOI 10.1016/0028-3932(94)00094-6
   Kadosh RC, 2007, CURR BIOL, V17, pR834
   Collignon O, CORTEX IN PRESS
   COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848
   Farran EK, 2011, AUTISM RES, V4, P283, DOI 10.1002/aur.202
   Foss-Feig JH, 2010, EXP BRAIN RES, V203, P381, DOI 10.1007/s00221-010-2240-4
   Frith U., 1989, AUTISM EXPLAINING EN
   Gallace A, 2006, PERCEPT PSYCHOPHYS, V68, P1191, DOI 10.3758/BF03193720
   GARNER WR, 1977, B PSYCHONOMIC SOC, V9, P380
   Grinter EJ, 2010, J CHILD PSYCHOL PSYC, V51, P717, DOI 10.1111/j.1469-7610.2009.02203.x
   HOLLAND MK, 1964, PERCEPT MOTOR SKILL, V19, P111
   Iarocci G, 2006, J AUTISM DEV DISORD, V36, P77, DOI 10.1007/s10803-005-0044-3
   JOLICOEUR P, 1987, J EXP PSYCHOL HUMAN, V13, P478, DOI 10.1037/0096-1523.13.3.478
   Klinger LG, 2001, DEV PSYCHOPATHOL, V13, P111, DOI 10.1017/S0954579401001080
   Kohler W., 1929, GESTALT PSYCHOL
   LEWKOWICZ DJ, 1980, DEV PSYCHOL, V16, P597
   Lord C., 2001, AUTISM DIAGNOSTIC OB
   MARKS LE, 1987, J EXP PSYCHOL HUMAN, V13, P384, DOI 10.1037/0096-1523.13.3.384
   MARKS LE, 1983, INT J NEUROSCI, V19, P1, DOI 10.3109/00207458309148640
   MARKS LE, 1987, MONOGR SOC RES CHILD, V52, P1
   MARKS LE, 1974, AM J PSYCHOL, V87, P173, DOI 10.2307/1422011
   Martino G, 1999, PERCEPTION, V28, P903, DOI 10.1068/p2866
   Maurer D, 2006, DEVELOPMENTAL SCI, V9, P316, DOI 10.1111/j.1467-7687.2006.00495.x
   MELARA RD, 1989, J EXP PSYCHOL HUMAN, V15, P212, DOI 10.1037//0096-1523.15.2.212
   MELARA RD, 1990, MEM COGNITION, V18, P477, DOI 10.3758/BF03198481
   MELARA RD, 1987, J EXP PSYCHOL GEN, V116, P323
   Mondloch CJ, 2004, COGN AFFECT BEHAV NE, V4, P133, DOI 10.3758/CABN.4.2.133
   Newman SS, 1933, AM J PSYCHOL, V45, P53, DOI 10.2307/1414186
   Nielsen A, 2011, CAN J EXP PSYCHOL, V65, P115, DOI 10.1037/a0022268
   Oberman LM, 2008, SOC NEUROSCI, V3, P348, DOI 10.1080/17470910701563681
   OBOYLE MW, 1987, J PSYCHOLINGUIST RES, V16, P273, DOI 10.1007/BF01067547
   Plaisted K, 2003, PHILOS T ROY SOC B, V358, P375, DOI 10.1098/rstb.2002.1211
   Ramachandran V, 2001, J CONSCIOUSNESS STUD, V8, P3
   Ramachandran Vilayanur S., 2003, SCI AM, V288, P43, DOI DOI 10.1038/SCIENTIFICAMERICAN0503-52
   Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x
   Sapir E, 1929, J EXP PSYCHOL, V12, P225, DOI 10.1037/h0070931
   Schaaf R, 2011, J AUTISM DEV DISORD, V41, P1436, DOI 10.1007/s10803-011-1303-0
   SHULMAN C, 1995, J ABNORM PSYCHOL, V104, P601, DOI 10.1037//0021-843X.104.4.601
   Soulieres I, 2007, J AUTISM DEV DISORD, V37, P481, DOI 10.1007/s10803-006-0172-4
   Spence C, 2011, ATTEN PERCEPT PSYCHO, V73, P971, DOI 10.3758/s13414-010-0073-7
   Taya S, 2007, PERCEPTION, V36, P3, DOI 10.1068/p5597
   Thompson PD, 2011, Q J EXP PSYCHOL, V64, P2392, DOI 10.1080/17470218.2011.605898
   WALKER R, 1987, PERCEPT PSYCHOPHYS, V42, P491, DOI 10.3758/BF03209757
   Westbury C, 2005, BRAIN LANG, V93, P10, DOI 10.1016/j.bandl.2004.07.006
NR 49
TC 0
Z9 0
PU PION LTD
PI LONDON
PA 207 BRONDESBURY PARK, LONDON NW2 5JN, ENGLAND
SN 0301-0066
J9 PERCEPTION
JI Perception
PY 2013
VL 42
IS 2
BP 233
EP 241
DI 10.1068/p7357
PG 9
WC Psychology; Psychology, Experimental
SC Psychology
GA 133ME
UT WOS:000318141700010
PM 23700961
ER

PT J
AU Brosnan, M
   Ashwin, C
   Gamble, T
AF Brosnan, Mark
   Ashwin, Chris
   Gamble, Tim
TI Greater Empathizing and reduced Systemizing in people who show a jumping
   to conclusions bias in the general population: Implications for
   psychosis
SO PSYCHOSIS-PSYCHOLOGICAL SOCIAL AND INTEGRATIVE APPROACHES
LA English
DT Article
DE jumping to conclusions; Empathizing; Systemizing; hypermentalizing;
   global/local processing; psychosis; clinical psychology; delusions;
   theory of mind
ID MALE BRAIN THEORY; PERSECUTORY DELUSIONS; AUTISM; SCHIZOPHRENIA;
   SCHIZOTYPY; SYMPTOMS
AB Background: Females generally perform better than males on some measures of social processing (e. g. Empathizing), while males typically perform better than females on some measures of non-social processing (e. g. Systemizing). Extremes of these sex-typical cognitive profiles are associated with the development and maintenance of certain psychiatric disorders. For example, the autismpsychosis model predicts psychosis spectrum conditions can be characterized as a cognitive pattern of very poor Systemizing alongside superior Empathizing ability (autism demonstrating the diametrically opposing cognitive profile). However, little experimental research has been carried out to date testing the cognitive profile associated with psychosis.
   Methods: The present study used a large non-clinical sample to investigate the relationship between a "jumping to conclusions" (JTC) reasoning bias commonly seen in patients with delusions and measures of Empathizing and Systemizing.
   Results: Those showing a JTC bias demonstrated greater Empathizing and reduced Systemizing compared to a non-JTC group, irrespective of biological sex. Sex differences were identified in Empathizing and Systemizing but not the JTC.
   Conclusions: These results show a cognitive pattern consistent with predictions from the autism-psychosis model. In a non-clinical population, a reasoning bias associated with delusions is associated with an Emphasizing/Systemizing profile opposite to that characteristic of autism.
C1 [Brosnan, Mark; Ashwin, Chris; Gamble, Tim] Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England.
RP Brosnan, M (reprint author), Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England.
EM pssmjb@bath.ac.uk
CR Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337
   Baron-Cohen S., 2002, HDB COGNITIVE DEV, P491
   Baron-Cohen S., 2003, ESSENTIAL DIFFERENCE
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   BEBBINGTON P, 1995, INT J METHOD PSYCH, V5, P11
   Bentall RP, 2001, CLIN PSYCHOL REV, V21, P1143, DOI 10.1016/S0272-7358(01)00106-4
   Blakemore SJ, 2003, PSYCHOL MED, V33, P1433, DOI 10.1017/S0033291703008341
   Brosnan M, 2010, PERS INDIV DIFFER, V49, P738, DOI 10.1016/j.paid.2010.06.018
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P261, DOI 10.1017/S0140525X08004214
   Dassonville P., 2010, J VISION, V10, P458, DOI [10.1167/10.7.458, DOI 10.1167/10.7.458]
   Falter CM, 2008, J AUTISM DEV DISORD, V38, P507, DOI 10.1007/s10803-007-0419-8
   Freeman D, 2007, CLIN PSYCHOL REV, V27, P425, DOI 10.1016/j.cpr.2006.10.004
   Freeman D, 2008, SCHIZOPHR RES, V102, P254, DOI 10.1016/j.schres.2008.03.020
   Frith C., 1992, COGNITIVE NEUROPSYCH
   Garety PA, 2001, PSYCHOL MED, V31, P189
   Johnson SC, 2005, BIOL PSYCHIAT, V58, P937, DOI 10.1016/j.biopsych.2005.04.053
   Langdon R, 2010, SCHIZOPHRENIA BULL, V36, P321, DOI 10.1093/schbul/sbn069
   Lincoln TM, 2010, J ABNORM PSYCHOL, V119, P40, DOI 10.1037/a0018118
   Maric N, 2003, SCHIZOPHR RES, V63, P89, DOI 10.1016/S0920-9964(02)00380-8
   MASON O, 1995, PERS INDIV DIFFER, V18, P7, DOI 10.1016/0191-8869(94)00132-C
   Murphy J, 2010, PSYCHOSIS, V2, P199, DOI 10.1080/17522430903437087
   Russell TA, 2006, SCHIZOPHR RES, V81, P101, DOI 10.1016/j.schres.2005.10.002
   Russell-Smith SN, 2010, J AUTISM DEV DISORD, V40, P968, DOI 10.1007/s10803-010-0945-7
   van Os J, 2000, SCHIZOPHR RES, V45, P11, DOI 10.1016/S0920-9964(99)00224-8
   Wakabayashi A, 2006, PERS INDIV DIFFER, V41, P929, DOI 10.1016/j.paid.2006.03.017
NR 27
TC 5
Z9 5
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1752-2439
J9 PSYCHOSIS
JI Psychosis
PY 2013
VL 5
IS 1
BP 71
EP 81
DI 10.1080/17522439.2011.626526
PG 11
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 133VU
UT WOS:000318169700007
ER

PT J
AU Campbell, JM
AF Campbell, Jonathan M.
TI Commentary on PND at 25
SO REMEDIAL AND SPECIAL EDUCATION
LA English
DT Editorial Material
DE single case research design; meta-analysis
ID SINGLE-SUBJECT RESEARCH; QUANTITATIVE SYNTHESIS; PROBLEM BEHAVIOR;
   METAANALYSIS; METHODOLOGY; PERCENTAGE
AB The author provides commentary on the scientific enterprise of single-case meta-analysis, including experiences with and use of the percentage of nonoverlapping data statistic. The author provides a brief review and commentary on the benefits and liabilities of the PND statistic as well as other effect size metrics. The article includes general commentary about the perception and position of single-subject meta-analysis and its use to inform health insurance decision making in the field of autism. The commentary ends with predictions and recommendations for single-case meta-analysis in the next 25 years.
C1 Univ Kentucky, Lexington, KY 40506 USA.
RP Campbell, JM (reprint author), Univ Kentucky, 236 Dickey Hall, Lexington, KY 40506 USA.
EM jonathan.campbell@uky.edu
CR Campbell J. M., 2010, SINGLE SUBJECT RES M, P417
   Campbell JM, 2004, BEHAV MODIF, V28, P234, DOI 10.1177/0145445503259264
   Campbell JM, 2003, RES DEV DISABIL, V24, P120, DOI 10.1016/S0891-4222(03)00014-3
   Cigna Companies, 2011, INT BEH INT
   Cooper H, 2009, HDB RES SYNTHESIS ME, P3
   Cooper H., 2009, HDB RES SYNTHESIS ME, P19
   Didden R, 1997, AM J MENT RETARD, V101, P387
   Faith M. S., 1996, DESIGN ANAL SINGLE C, P245
   Gast D., 2010, SINGLE SUBJECT RES M, P199
   Kratochwill T. R., 2010, SINGLE CASE DESIGNS
   Ma HH, 2006, BEHAV MODIF, V30, P598, DOI 10.1177/0145445504272974
   Maggin DM, 2011, EXCEPTIONALITY, V19, P109, DOI 10.1080/09362835.2011.565725
   Moher D, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000097
   Parker RI, 2011, BEHAV MODIF, V35, P303, DOI 10.1177/0145445511399147
   Parker RI, 2007, J SPEC EDUC, V40, P194, DOI 10.1177/00224669070400040101
   Parker RI, 2009, EXCEPT CHILDREN, V75, P135
   Rindskopf D. M., 2008, IES RES TRAIN I SING
   SALZBERG CL, 1987, REM SPEC EDUC, V8, P43
   Schlosser R. W., 2007, EVIDENCE BASED COMMU, V1, P138, DOI DOI 10.1080/17489530802505412
   SCOTTI JR, 1991, AM J MENT RETARD, V96, P233
   Scruggs TE, 2013, REM SPEC EDUC, V34, P9, DOI 10.1177/0741932512440730
   SCRUGGS TE, 1987, REM SPEC EDUC, V8, P24
   Shadish W. R., 2008, EVIDENCE BASED COMMU, V3, P188, DOI 10. 1080/17489530802581603
   Shadish W. R., 2007, NEW DIRECTIONS EVALU, V113, P95
   United HealthCare Services Inc., 2011, INT BEH THER TREATM
   Van den Noortgate W, 2003, SCHOOL PSYCHOL QUART, V18, P325
   Vannest K. J., 2011, SINGLE CASE RES WEB
   Wolery M, 2010, J SPEC EDUC, V44, P18, DOI 10.1177/0022466908328009
NR 28
TC 5
Z9 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0741-9325
J9 REM SPEC EDUC
JI Remedial Spec. Educ.
PD JAN-FEB
PY 2013
VL 34
IS 1
SI SI
BP 20
EP 25
DI 10.1177/0741932512454725
PG 6
WC Education, Special
SC Education & Educational Research
GA 135IS
UT WOS:000318282400003
ER

PT J
AU Kover, ST
   Atwood, AK
AF Kover, Sara T.
   Atwood, Amy K.
TI Establishing Equivalence: Methodological Progress in Group-matching
   Design and Analysis
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE matching; equivalence; methodology; autism; comparison;
   neurodevelopmental disorders
ID WILLIAMS-SYNDROME; CAUSAL INFERENCE; DEVELOPMENTAL TRAJECTORIES;
   COGNITIVE DEFICITS; NULL HYPOTHESIS; DOWN-SYNDROME; AUTISM; DISORDERS;
   VARIABLES; ISSUES
AB This methodological review draws attention to the challenges faced by intellectual and developmental disabilities researchers in the appropriate design and analysis of group comparison studies. We provide a brief overview of matching methodologies in the field, emphasizing group-matching designs used in behavioral research on cognition and language in neurodevelopmental disorders, including autism spectrum disorder, Fragile X syndrome, Down syndrome, and Williams syndrome. The limitations of relying on p values to establish group equivalence are discussed in the context of other existing methods: equivalence tests, propensity scores, and regression-based analyses. Our primary recommendation for advancing research on intellectual and developmental disabilities is the use of descriptive indices of adequate group matching: effect sizes (i.e., standardized mean differences) and variance ratios.
C1 [Kover, Sara T.] Univ Wisconsin Madison, Waisman Ctr, Madison, WI 53705 USA.
   [Atwood, Amy K.] Univ Wisconsin Madison, Madison, WI 53705 USA.
RP Kover, ST (reprint author), Univ Wisconsin Madison, Waisman Ctr, 1500 Highland Ave, Madison, WI 53705 USA.
EM kover@wisc.edu
CR Abbeduto L, 2010, AJIDD-AM J INTELLECT, V115, P1, DOI 10.1352/1944-7558-115.1.1
   American Psychological Association, 2010, PUBL MAN AM PSYCH AS, V6th
   Atwood A. K., 2010, ANN M AM ED RES ASS
   Bakeman R., 2006, MONOGRAPHS SOC RES C, V71, P127, DOI DOI 10.1111/J.1540-5834.2006.00408.X
   Beeghly M, 2006, DEV PSYCHOPATHOL, V18, P737, DOI 10.1017/S0954579406060366
   Blackford JU, 2009, INTELLECT DEV DISAB, V47, P348, DOI 10.1352/1934-9556-47.5.348
   Breaugh JA, 2007, ORGAN RES METHODS, V10, P523, DOI 10.1177/1094428106292895
   Brock J, 2007, CLIN LINGUIST PHONET, V21, P673, DOI 10.1080/02699200701541433
   Brown J, 2010, Q J EXP PSYCHOL, V63, P1789, DOI 10.1080/17470210903536910
   Burack JA, 2004, J AUTISM DEV DISORD, V34, P3, DOI 10.1023/B:JADD.0000018275.59897.10
   Burack JA, 2002, DEV PSYCHOPATHOL, V14, P225
   Cicchetti DV, 2011, J AUTISM DEV DISORD, V41, P168, DOI 10.1007/s10803-010-1035-6
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
   EDGELL SE, 1995, MEM COGNITION, V23, P525, DOI 10.3758/BF03197252
   Eigsti IM, 2011, RES AUTISM SPECT DIS, V5, P681, DOI 10.1016/j.rasd.2010.09.001
   Facon B, 2011, RES DEV DISABIL, V32, P2134, DOI 10.1016/j.ridd.2011.07.029
   Fraser M. W., 2009, ADV QUANTITATIVE TEC
   FRICK RW, 1995, MEM COGNITION, V23, P132, DOI 10.3758/BF03210562
   HOLLAND PW, 1986, J AM STAT ASSOC, V81, P945, DOI 10.2307/2289064
   Imai K, 2008, J R STAT SOC A STAT, V171, P481, DOI 10.1111/j.1467-985X.2007.00527.x
   Jarrold C, 2004, J AUTISM DEV DISORD, V34, P81, DOI 10.1023/B:JADD.0000018078.82542.ab
   Jarrold C, 2007, CORTEX, V43, P233, DOI 10.1016/S0010-9452(08)70478-7
   Karmiloff-Smith A, 2004, J CHILD PSYCHOL PSYC, V45, P1258, DOI 10.1111/j.1469-7610.2004.00322.x
   Kover S., 2012, RECEPTIVE VOCA UNPUB
   Marsh HW, 1998, J EXP EDUC, V66, P163
   Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8
   Mervis CB, 2008, J SPEECH LANG HEAR R, V51, P967, DOI 10.1044/1092-4388(2008/071)
   Mervis CB, 1999, MONOGR SOC RES CHILD, V64, P115, DOI 10.1111/1540-5834.00011
   Miller GA, 2001, J ABNORM PSYCHOL, V110, P40, DOI 10.1037//0021-843X.110.1.40
   Newcombe NS, 2003, CHILD DEV, V74, P1050, DOI 10.1111/1467-8624.00588
   Piaggio G, 2006, JAMA-J AM MED ASSOC, V295, P1152, DOI 10.1001/jama.295.10.1152
   R Development Core Team, 2010, R LANG ENV STAT COMP
   ROGERS JL, 1993, PSYCHOL BULL, V113, P553, DOI 10.1037//0033-2909.113.3.553
   ROSENBAUM PR, 1989, J AM STAT ASSOC, V84, P1024, DOI 10.2307/2290079
   ROSENBAUM PR, 1985, AM STAT, V39, P33, DOI 10.2307/2683903
   RUBIN DB, 1974, J EDUC PSYCHOL, V66, P688, DOI 10.1037/h0037350
   Rubin DB, 2001, HLTH SERV OUTCOMES R, V2, P169, DOI DOI 10.1023/A:1020363010465
   Schervish MJ, 1996, AM STAT, V50, P203, DOI 10.2307/2684655
   SCHUIRMANN DJ, 1987, J PHARMACOKINET BIOP, V15, P657, DOI 10.1007/BF01068419
   Serlin R. C., 1993, HDB DATA ANAL BEHAV, V1, P199
   SERLIN RC, 1985, AM PSYCHOL, V40, P73, DOI 10.1037/0003-066X.40.1.73
   Shadish W, 2002, EXPT QUASIEXPERIMENT
   Shadish W.R., 2010, NEWBORN INFANT NURSI, V10, P19, DOI DOI 10.1053/J.NAINR.2009.12.010
   Stegner BL, 1996, EVAL PROGRAM PLANN, V19, P193, DOI 10.1016/0149-7189(96)00011-0
   Steiner P. M., 2012, OXFORD HDB QUANTITAT
   Steiner PM, 2010, PSYCHOL METHODS, V15, P250, DOI 10.1037/a0018719
   Strauss ME, 2001, J ABNORM PSYCHOL, V110, P6, DOI 10.1037//0021-843X.110.1.6
   Stuart EA, 2010, STAT SCI, V25, P1, DOI 10.1214/09-STS313
   Thomas MSC, 2009, J SPEECH LANG HEAR R, V52, P336, DOI 10.1044/1092-4388(2009/07-0144)
   Towgood KJ, 2009, NEUROPSYCHOLOGIA, V47, P2981, DOI 10.1016/j.neuropsychologia.2009.06.028
   TUPPER DE, 1984, J CLIN NEUROPSYCHOL, V6, P441, DOI 10.1080/01688638408401234
   WESTLAKE WJ, 1979, BIOMETRICS, V35, P273, DOI 10.2307/2529949
   Zimmerman DW, 2004, BRIT J MATH STAT PSY, V57, P173, DOI 10.1348/000711004849222
NR 54
TC 12
Z9 12
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD JAN
PY 2013
VL 118
IS 1
BP 3
EP 15
DI 10.1352/1944-7558-118.1.3
PG 13
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 130JZ
UT WOS:000317912500002
PM 23301899
ER

PT J
AU Carter, EW
   Lane, KL
   Cooney, M
   Weir, K
   Moss, CK
   Machalicek, W
AF Carter, Erik W.
   Lane, Kathleen Lynne
   Cooney, Molly
   Weir, Katherine
   Moss, Colleen K.
   Machalicek, Wendy
TI Parent Assessments of Self-determination Importance and Performance for
   Students with Autism or Intellectual Disability
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE self-determination; families; severe disabilities; autism; inclusion
ID TRANSITION-AGE YOUTH; DETERMINATION SKILLS; MENTAL-RETARDATION; SPECIAL
   EDUCATORS; PERSPECTIVES; OPPORTUNITIES; ELEMENTARY; PREDICTORS;
   TEACHERS; CHILDREN
AB Fostering student self-determination is now considered an essential element of special education and transition services for children and youth with intellectual disability and/ or autism. Yet, little is known about the pivotal role parents might play beyond the school campus in fostering self-determination among their children with developmental disabilities. We examined how 627 parents of children with intellectual disability or autism attending one of 34 randomly selected school districts (a) rated the importance of 7 component skills associated with self-determination, (b) assessed their children's performance in relation to those 7 skills, and (c) evaluated the overall self-determination capacities of their children. Although parents highly valued all of the self-determination skills, the degree to which their children were reported to perform the skills well was fairly low. Several factors predicted higher levels of self-determination, including educational setting, the presence of challenging behaviors, and perceived disability severity. We conclude by offering recommendations for equipping parents to better support their children's self-determination development.
C1 [Carter, Erik W.] Vanderbilt Univ, Nashville, TN USA.
   [Lane, Kathleen Lynne] Univ Kansas, Lawrence, KS 66045 USA.
   [Cooney, Molly; Weir, Katherine; Moss, Colleen K.] Univ North Carolina Chapel Hill, Waisman Ctr, Chapel Hill, NC USA.
   [Machalicek, Wendy] Univ Oregon, Eugene, OR 97403 USA.
RP Carter, EW (reprint author), Vanderbilt Univ, PMB 228,110 Magnolia Circle, Nashville, TN USA.
EM erik.carter@vanderbilt.edu
CR American Association on Intellectual and Developmental Disabilities & The Arc, 2008, SELF DET POL STAT
   BorthwickDuffy SA, 1997, RES DEV DISABIL, V18, P415, DOI 10.1016/S0891-4222(97)00020-6
   Brotherson MJ, 2008, J EARLY INTERVENTION, V31, P22, DOI 10.1177/1053815108324445
   Carter EW, 2011, BEHAV DISORDERS, V36, P100
   Carter EW, 2011, RES PRACT PERS SEV D, V36, P1
   Carter EW, 2009, AJIDD-AM J INTELLECT, V114, P179, DOI 10.1352/1944-7558-114.3.179
   Carter EW, 2008, EXCEPT CHILDREN, V75, P55
   Carter EW, 2006, EXCEPT CHILDREN, V72, P333
   Cho HJ, 2011, J SPEC EDUC, V45, P149, DOI 10.1177/0022466910362588
   Cobb B., 2009, CAREER DEV EXCEPTION, V32, P108, DOI [10.1177/0885728809336654, DOI 10.1177/0885728809336654]
   Council for Exceptional Children, 2009, WHAT EV SPEC ED MUST
   Field S, 1999, FOCUS AUTISM OTHER D, V14, P36, DOI DOI 10.1177/108835769901400105
   Field S. S., 1998, CAREER DEV EXCEPTION, V21, P113, DOI [10.1177/088572889802100202, DOI 10.1177/088572889802100202]
   Fujiura GT, 2000, EXCEPT CHILDREN, V66, P187
   Grigal M, 2003, EXCEPT CHILDREN, V70, P97
   Halpern A. S., 1997, NEXT STEP CURRICULUM
   Hoffman A., 2007, ASSESSMENT EFFECTIVE, V32, P181, DOI DOI 10.1177/15345084070320030601
   Kelley KR, 2013, REM SPEC EDUC, V34, P67, DOI 10.1177/0741932511415864
   Kleinbaum D, 1998, APPL REGRESSION ANAL, V3rd
   Lee S., 2006, TEACHING EXCEPTIONAL, V38, P36
   Mithaug D. E., 2003, SELF DETERMINED LEAR
   National Council for Accreditation of Teacher Education, 2008, PROF STAND ACCR TEAC
   Pierson M. R., 2008, CAREER DEV EXCEPTION, V31, P115, DOI DOI 10.1177/0885728808317659
   Ryan R. M., 2002, HDB SELF DETERMINATI
   Schalock R. L., 2010, INTELLECTUAL DISABIL, V11th
   Shogren K. A., 2011, CAREER DEV EXCEPTION, V34, P115, DOI [10.1177/0885728811398271, DOI 10.1177/0885728811398271]
   Shogren K. A., 2008, ASSESSMENT EFFECTIVE, V33, P94, DOI DOI 10.1177/1534508407311395
   Shogren KA, 2006, RES PRACT PERS SEV D, V31, P338
   Shogren KA, 2012, REM SPEC EDUC, V33, P320, DOI 10.1177/0741932511410072
   Shogren KA, 2004, J POSIT BEHAV INTERV, V6, P228, DOI 10.1177/10983007040060040401
   Shogren KA, 2007, EXCEPT CHILDREN, V73, P488
   Stang KK, 2009, J SPEC EDUC, V43, P94, DOI 10.1177/0022466907313452
   TASH, 2000, TASH RES CHOIC
   Test D. W., 2009, CAREER DEV EXCEPTION, V32, P115, DOI [10.1177/0885728809336859, DOI 10.1177/0885728809336859]
   Thoma C., 2010, GETTING MOST OUT IEP
   Wehmeyer M. L., 2007, INSTRUCTIONAL ASSESS
   Wehmeyer M. L., 2003, THEORY SELF DETERMIN
   Wehmeyer M. L., 2000, ARCS SELF DETERMINAT
   Wehmeyer M. L, 2000, EARLY EDUC DEV, V11, P465, DOI 10.1207/s15566935eed1104_6
   Wehmeyer M. L., 2007, PROMOTING SELF DETER
   Wehmeyer M. L., 2004, WHOSE FUTURE IS IT A
   Wehmeyer ML, 2011, EXCEPTIONALITY, V19, P19, DOI 10.1080/09362835.2011.537225
   Wehmeyer ML, 2000, J SPEC EDUC, V34, P58, DOI 10.1177/002246690003400201
   Wehmeyer ML, 2004, EXCEPT CHILDREN, V70, P413
   Wehmeyer ML, 2003, J APPL RES INTELLECT, V16, P255, DOI 10.1046/j.1468-3148.2003.00161.x
   Wehmeyer ML, 2005, RES PRACT PERS SEV D, V30, P113, DOI 10.2511/rpsd.30.3.113
   Weir K., 2011, FOSTERING SELF DETER
   Wolman J. M., 1994, AIR SELF DETERMINATI
   Zhang D., 2006, RES PRACT PERS SEV D, V30, P154
   Zhang DL, 2010, EDUC TRAIN AUTISM DE, V45, P175
   Zhang DL, 2005, REM SPEC EDUC, V26, P55, DOI 10.1177/07419325050260010701
   Zhang DL, 2001, EDUC TRAIN MENT RET, V36, P357
   Zhang J., 2002, CAREER DEV EXCEPTION, V25, P157
NR 53
TC 7
Z9 7
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD JAN
PY 2013
VL 118
IS 1
BP 16
EP 31
DI 10.1352/1944-7558-118.1.16
PG 16
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 130JZ
UT WOS:000317912500003
PM 23301900
ER

PT J
AU Grondhuis, SN
   Mulick, JA
AF Grondhuis, Sabrina Nicole
   Mulick, James A.
TI Comparison of the Leiter International Performance Scale-Revised and the
   Stanford-Binet Intelligence Scales, 5th Edition, in Children with Autism
   Spectrum Disorders
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; intelligence; assessment; cognitive functioning; evaluation
ID PERVASIVE DEVELOPMENTAL DISORDERS; EPIDEMIOLOGY; INDIVIDUALS; SCORES;
   LEVEL; IQ
AB A review of hospital records was conducted for children evaluated for autism spectrum disorders who completed both the Leiter International Performance Scale-Revised (Leiter-R) and Stanford-Binet Intelligence Scales, 5th Edition (SB5). Participants were between 3 and 12 years of age. Diagnoses were autistic disorder (n = 26, 55%) and pervasive developmental disorder-not otherwise specified (n = 21, 45%). Analysis showed that the full sample received significantly higher scores on the Leiter-R than SB5 (mean discrepancy of 20.91 points), specific diagnosis was not a significant factor, and younger children had a larger discrepancy between tests. These analyses strongly suggest that the Leiter-R and the SB5 may not be equivalent measures of intellectual functioning in children with autism spectrum disorders, and that use of one or the other exclusively could lead to misclassification of intellectual capacity.
C1 [Grondhuis, Sabrina Nicole] Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
   [Mulick, James A.] Ohio State Univ, Columbus, OH 43210 USA.
RP Grondhuis, SN (reprint author), Ohio State Univ, Nisonger Ctr, 1581 Dodd Dr 175, Columbus, OH 43210 USA.
EM sabrina.grondhuis@gmail.com
CR Amaral D., 2011, AUTISM SPECTRUM DISO
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Banach R, 2009, J AUTISM DEV DISORD, V39, P188, DOI 10.1007/s10803-008-0612-4
   Bolte S, 2002, CHILD PSYCHIAT HUM D, V33, P165, DOI 10.1023/A:1020734325815
   Bracken B. A., 1998, UNIVERSAL NONVERBAL
   Bradley-Johnson S, 1998, PSYCHOL SCHOOLS, V35, P195
   Bryson SE, 1998, MENT RETARD DEV D R, V4, P97, DOI 10.1002/(SICI)1098-2779(1998)4:2<97::AID-MRDD6>3.0.CO;2-U
   Campbell JM, 2008, J PEDIATR PSYCHOL, V33, P999, DOI 10.1093/jpepsy/jsm138
   Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
   Coolican J, 2008, J AUTISM DEV DISORD, V38, P190, DOI 10.1007/s10803-007-0368-2
   DeThorne LS, 2004, AM J SPEECH-LANG PAT, V13, P275, DOI 10.1044/1058-0360(2004/029)
   Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Hooper VS, 2006, PSYCHOL SCHOOLS, V43, P143, DOI 10.1002/pits.20136
   Kuschner ES, 2007, J AUTISM DEV DISORD, V37, P795, DOI 10.1007/s10803-006-0209-8
   Lecavalier L, 2011, AUT CHILD PSYCHO, P37, DOI 10.1007/978-1-4419-8065-6_4
   Leiter R. G., 1979, LEITER INT PERFORMAN
   Lennen DT, 2010, RES AUTISM SPECT DIS, V4, P95, DOI 10.1016/j.rasd.2009.09.004
   Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0
   LORD C, 1989, J AUTISM DEV DISORD, V19, P483, DOI 10.1007/BF02212853
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C., 2011, ARCH GEN PSYCHIAT, DOI [10.001/archgenpsychiatry.2011.148, DOI 10.001/ARCHGENPSYCHIATRY.2011.148]
   MALTZ A, 1981, J AUTISM DEV DISORD, V11, P413
   Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
   Mayes SD, 2003, J AUTISM DEV DISORD, V33, P329, DOI 10.1023/A:1024462719081
   Pickett E, 2009, COGN BEHAV NEUROL, V22, P1, DOI 10.1097/WNN.0b013e318190d185
   Reeve R. R., 1983, J CONSULT CLIN PSYCH, V31, P458
   Roid G., 1997, LEITER INT PERFORMAN
   Roid G. H., 2009, PRACTITIONERS GUIDE, P265
   Roid G. H., 2003, STANFORD BINET INTEL
   Rumsey JM, 1992, HIGH FUNCTIONING IND, P41
   Sattler J. M., 2008, ASSESSMENT CHILDREN, V5th
   Silverman W, 2010, INTELLIGENCE, V38, P242, DOI 10.1016/j.intell.2009.12.005
   Sparrow SS, 2000, J CHILD PSYCHOL PSYC, V41, P117, DOI 10.1017/S0021963099004989
   Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE
   Tsastsanis K. D., 2003, J AUTISM DEV DISORD, V33, P23
   VOLKMAR FR, 1993, J AUTISM DEV DISORD, V23, P579, DOI 10.1007/BF01046103
   Wechsler D., 2003, WECHSLER INTELLIGENC
NR 38
TC 1
Z9 1
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD JAN
PY 2013
VL 118
IS 1
BP 44
EP 54
DI 10.1352/1944-7558-118.1.44
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 130JZ
UT WOS:000317912500005
PM 23301902
ER

PT J
AU Moss, J
   Oliver, C
   Nelson, L
   Richards, C
   Hall, S
AF Moss, Joanna
   Oliver, Chris
   Nelson, Lisa
   Richards, Caroline
   Hall, Scott
TI Delineating the Profile of Autism Spectrum Disorder Characteristics in
   Cornelia de Lange and Fragile X Syndromes
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism spectrum disorder; Cornelia de Lange syndrome; Fragile X
   syndrome; behavioral phenotypes
ID SELF-INJURIOUS-BEHAVIOR; GENOTYPE-PHENOTYPE CORRELATIONS; INTELLECTUAL
   DISABILITY; GENETIC SYNDROMES; SOCIAL ANXIETY; DOWN-SYNDROME; NIPPED-B;
   CHILDREN; COMMUNICATION; INDIVIDUALS
AB An atypical presentation of autism spectrum disorder is noted in Cornelia de Lange and Fragile X syndromes, but there are few detailed empirical descriptions. Participants in this study were individuals with Cornelia de Lange syndrome (n = 130, M age = 17.19), Fragile X syndrome (n 5 182, M age 5 16.94), and autism spectrum disorder (n = 142, M age = 15.19), who were comparable on chronological age. Using the Social Communication Questionnaire, the proportion meeting cutoff for autism spectrum disorder and autism was 78.6%, and 45.6%, respectively, in Cornelia de Lange syndrome and 83.6% and 48.6% in Fragile X syndrome. Domain and item analyses indicate differing, atypical autism spectrum disorder profiles in Fragile X and Cornelia de Lange syndromes. A limited association between adaptive behavior and autism spectrum disorder was identified in all groups. The findings have implications for intervention in genetic syndromes and conceptualization of autism spectrum disorder in the wider population.
C1 [Moss, Joanna] Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, Edgbaston, England.
   [Oliver, Chris; Nelson, Lisa; Richards, Caroline] Univ Birmingham, Birmingham B15 2TT, Edgbaston, England.
   [Hall, Scott] Stanford Univ, Stanford, CA 94305 USA.
RP Moss, J (reprint author), Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, Edgbaston, England.
EM j.f.moss@bham.ac.uk
RI Moss, Jo/C-8812-2009
CR Arron K, 2011, J INTELL DISABIL RES, V55, P109, DOI 10.1111/j.1365-2788.2010.01337.x
   Bailey DB, 2001, J AUTISM DEV DISORD, V31, P165
   Basile E, 2007, J INTELL DISABIL RES, V51, P671, DOI 10.1111/j.1365-2788.2007.00977.x
   Berney TP, 1999, ARCH DIS CHILD, V81, P333
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Bhuiyan ZA, 2006, J MED GENET, V43, P568, DOI 10.1136/jmg.2005.038240
   Bolte S, 2008, J AM ACAD CHILD PSY, V47, P719, DOI 10.1097/CHI.0b013e31816c42bd
   Burbidge C, 2010, J INTELL DISABIL RES, V54, P1078, DOI 10.1111/j.1365-2788.2010.01338.x
   Capone GT, 2005, AM J MED GENET A, V134A, P373, DOI 10.1002/ajmg.a.30622
   Carter JC, 2007, AM J MED GENET B, V144B, P87, DOI 10.1002/ajmg.b.30407
   Charman T, 2001, AUTISM, V5, P325, DOI 10.1177/1362361301005003010
   Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x
   Cornish K., 2007, CURRENT PEDIAT REV, V3, P61, DOI 10.2174/157339607779941660
   Cornish K, 2008, J INTELL DISABIL RES, V52, P469, DOI 10.1111/j.1365-2788.2008.01056.x
   Deardorff MA, 2007, AM J HUM GENET, V80, P485, DOI 10.1086/511888
   Demark JL, 2003, AM J MENT RETARD, V108, P314, DOI 10.1352/0895-8017(2003)108<314:BRBAAF>2.0.CO;2
   Dissanayake C, 2009, J CHILD PSYCHOL PSYC, V50, P290, DOI 10.1111/j.1469-7610.2008.01988.x
   Dykens E. M., 2000, GENETICS MENTAL RETA
   Eaves LC, 2006, J DEV BEHAV PEDIATR, V27, pS95, DOI 10.1097/00004703-200604002-00007
   Fecteau S, 2003, AUTISM, V7, P255, DOI 10.1177/1362361303007003003
   Fombonne E, 1999, PSYCHOL MED, V29, P769, DOI 10.1017/S0033291799008508
   Gillberg C., 2000, BIOL AUTISTIC SYNDRO
   Gillis LA, 2004, AM J HUM GENET, V75, P610, DOI 10.1086/424698
   GOODBAN MT, 1993, AM J MED GENET, V47, P1059, DOI 10.1002/ajmg.1320470725
   Hagerman RJ, 2005, CURR OPIN PSYCHIATR, V18, P490, DOI 10.1097/01.yco.0000179485.39520.b0
   Hall S, 2006, J AUTISM DEV DISORD, V36, P935, DOI 10.1007/s10803-006-0132-z
   Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001
   Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8
   Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770
   Hyman P, 2002, AM J MENT RETARD, V107, P146, DOI 10.1352/0895-8017(2002)107<0146:SIBSRA>2.0.CO;2
   Kaufmann WE, 2004, AM J MED GENET A, V129A, P225, DOI 10.1002/ajmg.a.30229
   Kline AD, 2007, AM J MED GENET C, V145C, P248, DOI 10.1002/ajmg.c.30137
   Krantz ID, 2004, NAT GENET, V36, P631, DOI 10.1038/ng1364
   KUSHLICK A, 1973, PSYCHOL MED, V3, P466
   Lesniak-Karpiak K, 2003, J AUTISM DEV DISORD, V33, P55, DOI 10.1023/A:1022230504787
   Lewis P, 2006, J INTELL DISABIL RES, V50, P532, DOI 10.1111/j.1365-2788.2006.00803.x
   Loesch DZ, 2007, NEUROSCI BIOBEHAV R, V31, P315, DOI 10.1016/j.neubiorev.2006.09.007
   Magiati I, 2007, J CHILD PSYCHOL PSYC, V48, P803, DOI 10.1111/j.1469-7610.2007.01756.x
   Magiati I, 2011, RES AUTISM SPECT DIS, V5, P1016, DOI 10.1016/j.rasd.2010.11.007
   Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x
   Miyake N, 2005, AM J MED GENET A, V135A, P103, DOI 10.1002/ajmg.a.30637
   Molloy CA, 2009, J INTELL DISABIL RES, V53, P143, DOI 10.1111/j.1365-2788.2008.01138.x
   Moss J., 2011, OXFORD HDB INTELLECT, P275
   Moss J, 2012, J CHILD PSYCHOL PSYC, V53, P883, DOI 10.1111/j.1469-7610.2012.02540.x
   Moss J, 2009, J AUTISM DEV DISORD, V39, P572, DOI 10.1007/s10803-008-0655-6
   Moss J, 2008, J AUTISM DEV DISORD, V38, P1081, DOI 10.1007/s10803-007-0487-9
   Moss J., AUTISM INT IN PRESS
   Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x
   Moss JF, 2008, AM J MENT RETARD, V113, P278, DOI 10.1352/0895-8017(2008)113[278:POASPI]2.0.CO;2
   Mount RH, 2003, AM J MENT RETARD, V108, P1, DOI 10.1352/0895-8017(2003)108<0001:TABPFR>2.0.CO;2
   Musio A, 2006, NAT GENET, V38, P528, DOI 10.1038/ng1779
   Oliver C., 2006, J INTELL DISABIL RES, V50, P791
   Oliver C, 2011, J AUTISM DEV DISORD, V41, P1019, DOI 10.1007/s10803-010-1125-5
   Oliver C, 2009, J INTELL DISABIL RES, V53, P575, DOI 10.1111/j.1365-2788.2009.01179.x
   Oliver C, 2008, BRIT J PSYCHIAT, V193, P466, DOI 10.1192/bjp.bp.107.044370
   Oliver C., 2010, J APPL RES INTELLECT, V23, P219
   PALMER J, 1982, BRIT J MENT SUBNORM, V28, P88
   Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
   Richards C, 2009, J AUTISM DEV DISORD, V39, P1155, DOI 10.1007/s10803-009-0730-7
   Richards C, 2012, J INTELL DISABIL RES, V56, P476, DOI 10.1111/j.1365-2788.2012.01537.x
   Roberts JE, 2007, J AUTISM DEV DISORD, V37, P1748, DOI 10.1007/s10803-006-0305-9
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sarimski K, 1997, J INTELL DISABIL RES, V41, P70, DOI 10.1111/j.1365-2788.1997.tb00678.x
   Skuse DH, 2007, TRENDS GENET, V23, P387, DOI 10.1016/j.tig.2007.06.003
   Sloneem J, 2009, J INTELL DISABIL RES, V53, P590, DOI 10.1111/j.1365-2788.2009.01183.x
   Starr E, 2003, J AUTISM DEV DISORD, V33, P15, DOI 10.1023/A:1022222202970
   Tonkin ET, 2004, NAT GENET, V36, P636, DOI 10.1038/ng1363
   Trillingsgaard A, 2004, AUTISM, V8, P163, DOI 10.1177/1362361304042720
   Turk J, 1998, J INTELL DISABIL RES, V42, P490, DOI 10.1046/j.1365-2788.1998.4260490.x
NR 70
TC 6
Z9 6
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD JAN
PY 2013
VL 118
IS 1
BP 55
EP 73
DI 10.1352/1944-7558-118.1.55
PG 19
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 130JZ
UT WOS:000317912500006
PM 23301903
ER

PT J
AU Eyal, G
AF Eyal, Gil
TI For a Sociology of Expertise: The Social Origins of the Autism Epidemic
SO AMERICAN JOURNAL OF SOCIOLOGY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; EARLY INFANTILE-AUTISM; CHILDHOOD
   SCHIZOPHRENIA; PSYCHOTIC-CHILDREN; DIAGNOSTIC SUBSTITUTION; SPECTRUM
   DISORDERS; PREVALENCE; PARENTS; CLASSIFICATION; CALIFORNIA
AB This article endeavors to replace the sociology of professions with the more comprehensive and timely sociology of expertise. It suggests that we need to distinguish between experts and expertise as requiring two distinct modes of analysis that are not reducible to one another. It analyzes expertise as a network linking together agents, devices, concepts, and institutional and spatial arrangements. It also suggests rethinking how abstraction and power were analyzed in the sociology of professions. The utility of this approach is demonstrated by using it to explain the recent precipitous rise in autism diagnoses. This article shows that autism remained a rare disorder until the deinstitutionalization of mental retardation created a new institutional matrix within which a new set of actors-the parents of children with autism in alliance with psychologists and therapists-were able to forge an alternative network of expertise.
C1 [Eyal, Gil] Columbia Univ, New York, NY 10027 USA.
RP Eyal, G (reprint author), Columbia Univ, Dept Sociol, 1180 Amsterdam Ave, New York, NY 10027 USA.
EM ge2027@columbia.edu
CR Abbott A., 1988, SYSTEM PROFESSIONS E
   Abbott A, 1995, SOC RES, V62, P857
   Abbott Andrew, 2001, CHAOS DISCIPLINES
   Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Akerley M., 1979, J AUTISM DEV DISORD, V9, P222
   [American Psychiatric Association Task Force on Nomenclature and Statistics], 1987, DIAGN STAT MAN MENT
   [American Psychiatric Association Task Force on Nomenclature and Statistics], 1968, DIAGN STAT MAN MENT
   American Psychiatric Association Task Force on DSM-IV, 1994, DIAGN STAT MAN MENT
   American Psychiatric Association Task Force on Nomenclature and Statistics Committee on Nomenclature and Statistics, 1980, DIAGN STAT MAN MENT
   Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
   [Anonymous], 1966, MED WORLD NEWS, V7, P85
   ARONSON N, 1982, SOC PROBL, V29, P474, DOI 10.1525/sp.1982.29.5.03a00040
   Ayres Jean, 1972, J AUTISM CHILDHOOD S, V2, P174
   Ayres Jean, 1974, DEV SENSORY INTEGRAT
   Ayres Jean, 1983, SENSORY INTEGRATION
   Ayres Jean, 1998, SENSORY INTEGRATION
   Bender L, 1953, PSYCHIAT QUART, V27, P663, DOI 10.1007/BF01562517
   Bernard S, 2004, JAMA-J AM MED ASSOC, V291, P180, DOI 10.1001/jama.291.2.180-b
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Bettelheim B., 1967, EMPTY FORTRESS INFAN
   Bishop Dorothy V. M., 2008, DEV MED CHILD NEUROL, V50, P1
   BLUMER H, 1971, SOC PROBL, V18, P298, DOI 10.1525/sp.1971.18.3.03a00020
   Brockley Janice, 2004, MENTAL RETARDATION A, P130
   Buchanan I., 2006, BRIT J LEARN DISABIL, V34, P133, DOI 10.1111/j.1468-3156.2006.00410.x
   Keating P, 2003, INSIDE TECHNOL, P1
   Cambrosio Alberto, 1992, CULTURE POWER KNOWLE, P341
   Carr ES, 2010, ANNU REV ANTHROPOL, V39, P17, DOI 10.1146/annurev.anthro.012809.104948
   Caruso D, 2010, AM J LAW MED, V36, P483
   Castles Katherine, 2004, MENTAL RETARDATION A, P351
   Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
   Clausen John, 1966, AM J MENT DEFIC, V71, P727
   Collins HM, 2002, SOC STUD SCI, V32, P235, DOI 10.1177/0306312702032002003
   Conrad P, 1980, DEVIANCE MED BADNESS
   Coo H, 2008, J AUTISM DEV DISORD, V38, P1036, DOI 10.1007/s10803-007-0478-x
   Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880
   DEWEY M, 1974, J AUTISM CHILD SCHIZ, V4, P348, DOI 10.1007/BF02105378
   Dreyfus H. L., 1986, MIND MACHINE POWER H
   Dreyfus HL, 2005, ORGAN STUD, V26, P779, DOI 10.1177/0170840605053102
   Dreyfus Hubert, 1979, WHAT COMPUTERS CANT
   EISENBERG L, 1956, AM J ORTHOPSYCHIAT, V26, P556
   EPSTEIN S, 1995, SCI TECHNOL HUM VAL, V20, P408, DOI 10.1177/016224399502000402
   Epstein Steven, 1996, IMPURE SCI AIDS ACTI
   Evans R, 2007, RETHINKING EXPERTISE
   Fields Suzanne, 1975, INNOVATIONS, V2, P3
   Fombonne E, 2009, INT J EPIDEMIOL, V38, P1241, DOI 10.1093/ije/dyp259
   Fombonne Eric, 1999, PSYCHOL MED, V29, P769
   Foucault M., 1973, BIRTH CLIN
   Foucault M., 1972, ARCHEOLOGY KNOWLEDGE
   Foucault Michel, 1975, DISCIPLINE PUNISH
   Friedson E., 1986, PROFESSIONAL POWERS
   Friedson E., 1970, PROFESSIONAL DOMINAN
   Gadamer H.-G., 1996, ENIGMA HLTH
   Gillberg C, 1998, BRIT J PSYCHIAT, V172, P200, DOI 10.1192/bjp.172.3.200
   Grandin T., 1995, THINKING PICTURES MY
   Grandin T., 1986, EMERGENCE LABELED AU
   Green VA, 2006, RES DEV DISABIL, V27, P70, DOI 10.1016/j.ridd.2004.12.002
   Grinker Roy Richard, 2007, UNSTRANGE MINDS REMA
   Gusfield Joseph, 1981, CULTURE PUBLIC PROBL
   Hacking I, 2009, PHILOS T R SOC B, V364, P1467, DOI 10.1098/rstb.2008.0329
   Haydu J, 1998, AM J SOCIOL, V104, P339, DOI 10.1086/210041
   Heritage J, 2006, ANNU REV SOCIOL, V32, P351, DOI 10.1146/annurev.soc.32.082905.093959
   HERSCH C, 1968, AM PSYCHOL, V23, P497, DOI 10.1037/h0026215
   HILGARTNER S, 1988, AM J SOCIOL, V94, P53, DOI 10.1086/228951
   Howlin P, 1997, EUR CHILD ADOLES PSY, V6, P55
   Jones Kathleen, 1999, TAMING TROUBLESOME C
   Jones Kathleen W., 2004, MENTAL RETARDATION A, P322
   Kanner L., 1964, HIST CARE STUDY MENT
   KANNER L, 1965, BEHAV SCI, V10, P412, DOI 10.1002/bs.3830100404
   Kanner L, 1941, DEFENSE MOTHERS BRIN
   KANNER L, 1971, J AUTISM CHILD SCHIZ, V1, P119, DOI 10.1007/BF01537953
   Kanner Leo, 1949, CHILD CARE MONOGRAPH
   Kanner Leo, 1973, CHILDHOOD PSYCHOSIS, P1
   King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
   King Marissa D., 2008, THESIS COLUMBIA U
   Kline Wendy, 2001, BUILDING BETTER RACE
   Koenig Kathleen, 2000, HDB INFANT MENTAL HL, P298
   KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x
   Lakoff A, 2005, CAMB STUD SOC LIFE S, P1, DOI 10.2277/ 0521546664
   Lane Pam, 2008, AUTISM MATTERS, V1, P3
   Langone John, 1974, GOODBYE BEDLAM UNDER
   Latour B., 1987, SCI ACTION FOLLOW SC
   Latour B, 2010, MAKING LAW ETHNOGRAP
   Latour Bruno, 1999, PANDORAS BOX ESSAYS
   Latour Bruno, 1988, PASTEURIZATION FRANC
   Lerner Barron H., 2006, ILLNESS GOES PUBLIC
   Lettick Amy L., 1979, BENHAVEN THEN NOW
   Liu K. Y., 2010, AM J SOCIOL, V115, P1389
   Lovaas O. I., 1981, TEACHING DEV DISABLE
   LOVAAS OI, 1979, J AUTISM DEV DISORD, V9, P315, DOI 10.1007/BF01531442
   LOVAAS OI, 1993, J APPL BEHAV ANAL, V26, P617, DOI 10.1901/jaba.1993.26-617
   Malzberg B, 1952, AM J MENT DEF, V57, P27
   May Jacques M., 1958, PHYS LOOKS PSYCHIAT
   MCGEE GG, 1985, J APPL BEHAV ANAL, V18, P17, DOI 10.1901/jaba.1985.18-17
   Michel Foucault, 1976, HIST SEXUALITY INTRO
   MOSSE HL, 1958, AM J PSYCHIAT, V114, P791
   Nadesan Majia Holmer, 2005, CONSTRUCTING AUTISM
   Nehring Wendy, 2004, MENTAL RETARDATION A, P371
   Noll Steven, 1995, FEEBLE MINDED OUR MI
   Norsworthy N., 1906, ARCH PSYCHOL, V1, P1
   ORNITZ EM, 1968, ARCH GEN PSYCHIAT, V18, P76
   Park Clara Claiborne, 1971, NSAC NEWSLETTER, V3, P3
   PARK D, 1974, J AUTISM CHILD SCHIZ, V4, P189, DOI 10.1007/BF02105371
   Pettus Ashley, 2008, HARVARD MAG, V110, P3
   Prior M, 2003, J PAEDIATR CHILD H, V39, P81, DOI 10.1046/j.1440-1754.2003.00097.x
   Prouty R, 2005, MENT RETARD, V43, P456, DOI 10.1352/0047-6765(2005)43[456:PTANOO]2.0.CO;2
   Prouty Robert W., 2001, RESIDENTIAL SERVICES
   Prouty Robert W., 2007, RESIDENTIAL SERVICES
   Rabeharisoa V., 2004, STATES KNOWLEDGE COP, P142
   Rapin Isabelle, 1994, NEUROBIOLOGY AUTISM, P1
   Rimland B., 1964, INFANTILE AUTISM SYN
   RIMLAND B, 1971, J AUTISM CHILD SCHIZ, V1, P161, DOI 10.1007/BF01537955
   RIMLAND B, 1968, ACTA PAEDOPSYCHIATR, V35, P146
   Rimland Bernard, 1972, READINGS EXCEPTIONAL, P573
   Rimland Bernard, 2006, RECOVERING AUTISTIC, P1
   Ritvo E. M., 1978, J AUTISM CHILDHOOD S, V8, P162
   Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
   Rose Nikolas, 1992, SCI CONTEXT, V5, P351, DOI 10.1017/S0269889700001228
   RUTTER M, 1978, J AUTISM CHILD SCHIZ, V8, P139, DOI 10.1007/BF01537863
   RUTTER M, 1972, J AUTISM CHILD SCHIZ, V2, P315, DOI 10.1007/BF01537622
   RUTTER M, 1971, J AUTISM CHILD SCHIZ, V1, P376
   RUTTER M, 1985, J CHILD PSYCHOL PSYC, V26, P193, DOI 10.1111/j.1469-7610.1985.tb02260.x
   SCHOPLER E, 1972, J AUTISM CHILD SCHIZ, V2, P387, DOI 10.1007/BF01538171
   SCHOPLER E, 1971, J AUTISM CHILD SCHIZ, V1, P87, DOI 10.1007/BF01537746
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   Schopler Eric, 1971, RES ED TOP PRIORITIE, P75
   Schopler Eric, 1976, PSYCHOPATHOLOGY CHIL
   SCHOPLER E, 1971, J CONTEMP PSYCHOTHER, V4, P17, DOI 10.1007/BF02110269
   SCHOPLER E, 1978, J AUTISM CHILD SCHIZ, V8, P137, DOI 10.1007/BF01537862
   Schumacher HC, 1946, AM J MENT DEF, V51, P52
   Shapiro J. P., 1993, NO PITY PEOPLE DISAB
   Shattuck PT, 2006, PEDIATRICS, V117, P1028, DOI 10.1542/peds.2005-1516
   Shore Stephen, 2003, WALL PERSONAL EXPERI
   Siegel B., 1996, WORLD AUTISTIC CHILD
   Silverman C, 2012, UNDERSTANDING AUTISM: PARENTS, DOCTORS, AND THE HISTORY OF A DISORDER, P1
   Silverman Chloe, 2004, THESIS U PENNSYLVANI
   Sinclair J, 1993, DONT MOURN US
   Spitz RA, 1945, PSYCHOANAL STUD CHIL, V1, P53
   Sullivan Ruth Christ, 1984, EFFECTS AUTISM FAMIL, P233
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Tammet D., 2009, EMBRACING WIDE SKY T
   Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1
   Tredgold A. F., 1908, TXB MENTAL DEFICIENC
   Trent Jr James W., 1994, INVENTING FEEBLE MIN
   VOLKMAR FR, 1993, J AUTISM DEV DISORD, V23, P579, DOI 10.1007/BF01046103
   Waldman M., 2006, 12632 NAT BUR EC RES
   Wallin J. E. Wallace, 1949, CHILDREN MENTAL PHYS
   Warren Frank, 1984, EFFECTS AUTISM FAMIL
   Waterhouse L, 2007, CA CH AD PS, P307, DOI 10.1017/CBO9780511544446.011
   WATERHOUSE L, 1992, J AUTISM DEV DISORD, V22, P525, DOI 10.1007/BF01046326
   Waterhouse Lynn, 1987, DIAGNOSIS CLASSIFICA, P335
   Weber M., 1963, SOCIOLOGY RELIG
   Whooley O, 2010, SOCIOL HEALTH ILL, V32, P452, DOI 10.1111/j.1467-9566.2010.01230.x
   Williams D., 1994, SOMEBODY SOMEWHERE B
   Williams D., 1992, NOBODY NOWHERE EXTRA
   Williams R., 1976, KEYWORDS
   Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0
   Wing L., 1973, RES ED TOP PRIORITIE, P106
   WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288
   Wing L, 2005, J AUTISM DEV DISORD, V35, P197, DOI 10.1007/s10803-005-1998-x
   WING L, 1981, PSYCHOL MED, V11, P115
   Wing Lorna, 2008, COMMUNICATION
   Wolfensberger W., 1972, NORMALIZATION PRINCI
   Wynne B, 1996, MISUNDERSTANDING SCI, P19, DOI 10.1017/CBO9780511563737.002
   Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
   ZOLA IK, 1972, SOCIOL REV, V20, P487
NR 167
TC 9
Z9 9
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0002-9602
EI 1537-5390
J9 AM J SOCIOL
JI Am. J. Sociol.
PD JAN
PY 2013
VL 118
IS 4
BP 863
EP 907
DI 10.1086/668448
PG 45
WC Sociology
SC Sociology
GA 125ZF
UT WOS:000317580100001
ER

PT J
AU Khayatzadeh, MM
   Rostami, HR
   Amirsalari, S
   Karimloo, M
AF Khayatzadeh, Mohammad Mahani
   Rostami, Hamid Reza
   Amirsalari, Susan
   Karimloo, Masood
TI Investigation of quality of life in mothers of children with cerebral
   palsy in Iran: association with socio-economic status, marital
   satisfaction and fatigue
SO DISABILITY AND REHABILITATION
LA English
DT Article
DE Cerebral palsy; fatigue; Iran; marital satisfaction; mothers; quality of
   life; socio-economic status
ID MENTAL-RETARDATION; PRIMARY CAREGIVERS; BEHAVIOR PROBLEMS; PARENTAL
   STRESS; BIRTH-WEIGHT; AUTISM; IMPACT; DISABILITY; FATHERS; HEALTH
AB Purpose: This study aimed to compare the quality of life (QOL) of Mothers of Children with Cerebral Palsy (MCCPs) with mothers of Typically Developing (TD) children as a Control Group (CG). The association of the mediating variables including socio-economic status (SES), marital satisfaction and fatigue with maternal QOL was also evaluated. Method: The MCCPs group consisted of 120 mothers (mean age: 30.3 +/- 5.5 years) of children with CP. The CG included 100 mothers (mean age: 29.9 +/- 4.5 years) of TD children. Demographic characteristics of the participants were recorded and the data was collected by World Health Organization Quality of Life-BREF (WHOQOL-BREF), SES Questionnaire, Index of Marital Satisfaction (IMS) and Fatigue Severity Scale-Persian (FSS-P). Data analysis was done by SPSS version 16.0. Results: The QOL and SES were lower, while FSS-P and IMS were higher in MCCPs group than CG (p < 0.001). The SES, IMS and FSS-P associated with all domains of QOL in MCCPs group, while they did just with some domains of QOL in CG (p < 0.05). Conclusions: The lower QOL in MCCPs group is supposed to be mediated by the SES, marital satisfaction and fatigue so, maternal empowerment in terms of these mediators and family-centered approach are recommended.
C1 [Khayatzadeh, Mohammad Mahani; Rostami, Hamid Reza] Ahvaz Jundishapur Univ Med Sci, Musculoskeletal Rehabil Res Ctr, Occupat Therapy Dept, Ahwaz, Iran.
   [Amirsalari, Susan] Baqi Atollah Univ Med Sci, Dept Neurol, Tehran, Iran.
   [Karimloo, Masood] Univ Wellfare & Rehabil, Dept Stat & Comp Sci, Tehran, Iran.
RP Khayatzadeh, MM (reprint author), Ahvaz Jundishapur Univ Med Sci, Musculoskeletal Rehabil Res Ctr, Occupat Therapy Dept, Ahwaz, Iran.
EM mahany2002@yahoo.com
CR Arnaud C, 2008, PEDIATRICS, V121, P54, DOI 10.1542/peds.2007-0854
   Azimian M., 2009, Research Journal of Biological Sciences, V4, P974
   Blacher J, 1997, AM J MENT RETARD, V101, P483
   Brehaut JC, 2004, PEDIATRICS, V114, P182
   Britner PA, 2003, J CHILD FAM STUD, V12, P335, DOI DOI 10.1023/A:1023943928358
   Button S, 2001, J DEV PHYS DISABIL, V13, P61, DOI 10.1023/A:1026509400487
   Davis E, 2010, CHILD CARE HLTH DEV, V36, P63, DOI 10.1111/j.1365-2214.2009.00989.x
   Dolk H, 2001, PAEDIATR PERINAT EP, V15, P359, DOI 10.1046/j.1365-3016.2001.00351.x
   DOWDING VM, 1990, J EPIDEMIOL COMMUN H, V44, P191, DOI 10.1136/jech.44.3.191
   Emerson E, 2003, J INTELL DISABIL RES, V47, P385, DOI 10.1046/j.1365-2788.2003.00498.x
   GATH A, 1977, BRIT J PSYCHIAT, V130, P405, DOI 10.1192/bjp.130.4.405
   Giallo R, 2013, AUTISM, V17, P465, DOI 10.1177/1362361311416830
   Hartley SL, 2011, AJIDD-AM J INTELLECT, V116, P81, DOI 10.1352/1944-7558-116.1.81
   Hastings RP, 2002, J INTELLECT DEV DIS, V27, P149, DOI 10.1080/1366825021000008657
   Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
   Hedov G, 2000, QUAL LIFE RES, V9, P415, DOI 10.1023/A:1008910527481
   Jan MMS, 2006, CAN J NEUROL SCI, V33, P306
   Kaya K, 2010, DISABIL REHABIL, V32, P1666, DOI 10.3109/09638281003649912
   Laskar AR, 2010, INDIAN J PEDIATR, V77, P529, DOI 10.1007/s12098-010-0064-7
   Meltzer LJ, 2006, ARCH INTERN MED, V166, P1749, DOI 10.1001/archinte.166.16.1749
   Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22
   Nedjat S., 2008, BMC HEALTH SERV RES, V<IT>21</IT>, P61
   Odding E, 2006, DISABIL REHABIL, V28, P183, DOI 10.1080/09638280500158422
   Ones K, 2005, NEUROREHAB NEURAL RE, V19, P232, DOI 10.1177/1545968305278857
   Pellegrino L., 2007, CHILDREN DISABILITIE, P443
   Quinn F., 1994, NURS STAND, V9, P47
   Quinn F, 1994, Nurs Stand, V9, P41
   Raina Parminder, 2004, BMC Pediatr, V4, P1, DOI 10.1186/1471-2431-4-1
   Rao PA, 2009, BEHAV MODIF, V33, P437, DOI 10.1177/0145445509336427
   Razavi M. H., 2010, J SPORT MANAGE, V2, P75
   Rentinck ICM, 2007, CHILD CARE HLTH DEV, V33, P161, DOI 10.1111/j.1365-2214.2006.00643.x
   Romeo DM, 2010, NEUROPEDIATRICS, V41, P121, DOI 10.1055/s-0030-1262841
   Rosenbaum PL, 2008, DEV MED CHILD NEUROL, V50, P249, DOI 10.1111/j.1469-8749.2008.02045.x
   Sajedi Firoozeh, 2010, Acta Med Iran, V48, P250
   Sjøbu L, 1994, Arctic Med Res, V53 Suppl 1, P30
   Smith LE, 2012, J AUTISM DEV DISORD, V42, P1836, DOI 10.1007/s10803-011-1422-7
   Strom H, 2011, J TROP PEDIATRICS, DOI [10.1093/tropej/fmr077, DOI 10.1093/TR0PEJ/FMR077]
   Sundrum R, 2005, ARCH DIS CHILD, V90, P15, DOI 10.1136/adc.2002.018937
   Terra VC, 2011, DISABIL REHABIL, V33, P384, DOI 10.3109/09638281003611052
   Torkan H., 2009, J PSYCHOL, V13, P3
   Tunali B, 2002, J AUTISM DEV DISORD, V32, P25, DOI 10.1023/A:1017999906420
   Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
   WHOQOL Group, 1997, WHOQOL US MAN ANN WH
   WILLOUGHBY JC, 1995, AM J MENT RETARD, V99, P399
NR 44
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0963-8288
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2013
VL 35
IS 10
BP 803
EP 808
DI 10.3109/09638288.2012.708818
PG 6
WC Rehabilitation
SC Rehabilitation
GA 130NR
UT WOS:000317925600002
PM 22900516
ER

PT J
AU Merceron, K
   Prouteau, A
AF Merceron, Karine
   Prouteau, Antoinette
TI Social cognition assessment in French language for adults: Available
   tools and recommendations for clinical practice
SO EVOLUTION PSYCHIATRIQUE
LA French
DT Article
DE Social cognition; Theory of mind; Emotion; Schizophrenia; Assessment
   scale; Neuropsychology
ID TORONTO-ALEXITHYMIA-SCALE; EMOTIONAL AWARENESS SCALE; HIGH-FUNCTIONING
   AUTISM; BASIC EMPATHY SCALE; ASPERGER-SYNDROME; SCHIZOPHRENIA;
   VALIDATION; MIND; DISORDERS; QUOTIENT
AB Social cognition is described as the processes underlying interpersonal relationships. The crucial role of these processes in rehabilitation, especially in adult psychiatry, has raised needs of clinical assessment in this particular cognitive domain. However, social cognition is a multidimensional construct which has been studied in numerous recent international researches. This review is aimed at inventorying available tools in French language for social cognition assessment in adults, and at drawing recommendation for practice in clinical neuropsychology. Results show that despite the lack of available tools, the assessment of social cognition is feasible in several dimensions, such as facial emotion recognition, theory of mind, alexithymia and emotional awareness. Each of the identified tools has specific benefits and limits that delimitate their potential usefulness. Globally, the incomplete validation of tools, as Well as their heterogeneity and their multidetermination should lead to some caution when assessing performances and interpreting results. However, when crossing assessments and controlling for basic neurocognitive difficulties, the identified tools can provide detailed information about each patient's social cognition profile. Studies remain necessary to further validate existing tools and to allow more reliable and diversified assessment. (C) 2013 Elsevier Masson SAS. All rights reserved.
C1 [Merceron, Karine] Ctr Rehabil Psychosociale Tour Gassies, F-33523 Brugge, France.
   [Prouteau, Antoinette] Ctr Hosp Jonzac, Dept Psychiat Adulte, F-17500 Jonzac, France.
RP Prouteau, A (reprint author), Univ Bordeaux, EA 4139, 3 Ter Pl de la Victoire, F-33000 Bordeaux, France.
EM antoinette.prouteau@u-bordeaux2.fr
CR Allen DN, 2007, SCHIZOPHR RES, V93, P325, DOI 10.1016/j.schres.2007.02.008
   ANDREASEN NC, 1986, SCHIZOPHRENIA BULL, V12, P473
   BAGBY RM, 1994, J PSYCHOSOM RES, V38, P33, DOI 10.1016/0022-3999(94)90006-X
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   BaronCohen S, 1997, VIS COGN, V4, P311, DOI 10.1080/713756761
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Bazin N, 2002, ENCEPHALE, V28, P109
   Bazin N, 2005, SCHIZOPHR RES, V77, P75, DOI 10.1016/j.schres.2005.01.020
   Bazin N, 2009, PSYCHIAT RES, V167, P28, DOI 10.1016/j.psychres.2007.12.010
   Bell MD, 2011, SCHIZOPHR B, DOI DOI 10.1093/SCHBULFSBR125
   Berthoz S, 2008, CAN J PSYCHIAT, V53, P469
   Berthoz S, 1999, EUR PSYCHIAT, V14, P372, DOI 10.1016/S0924-9338(99)00233-3
   Besche-Richard C, 2006, PSYCHOPATHOLOGIE EMO
   Bowers D, 1991, FLORIDA AFFECT BATTE
   Brunet Eric, 2003, Cogn Neuropsychiatry, V8, P129, DOI 10.1080/13546800244000256
   Brunet-Gouet E, 2011, PSYCHIAT RES, V190, P23, DOI 10.1016/j.psychres.2010.11.029
   Bydlowski S, 2002, ENCEPHALE, V28, P310
   CORCORAN R, 1995, SCHIZOPHR RES, V17, P5, DOI 10.1016/0920-9964(95)00024-G
   D'Ambrosio F, 2009, PERS INDIV DIFFER, V46, P160, DOI 10.1016/j.paid.2008.09.020
   Davis M. H., 1980, JSAS CATALOG SELECTE, V10, P85
   DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
   Decety J., 2004, EMPATHIE, P53
   Duval C, 2011, REV NEUROPSYCHOL, V3, P41
   Ekman P., 1976, PICTURES FACIAL AFFE
   Fett AKJ, 2011, NEUROSCI BIOBEHAV R, V35, P573, DOI 10.1016/j.neubiorev.2010.07.001
   Gaudelus B, 2012, REMEDIATION COGNITIV, P169
   Guttman HA, 2000, FAM PROCESS, V39, P345, DOI 10.1111/j.1545-5300.2000.39306.x
   Joanette Y, 2004, PROTOCOLE MONTREAL E
   Jolliffe D, 2006, J ADOLESCENCE, V29, P589, DOI 10.1016/j.adolescence.2005.08.010
   LANE RD, 1990, J PERS ASSESS, V55, P124, DOI 10.1207/s15327752jpa5501&2_12
   Lane RD, 1997, BIOL PSYCHIAT, V42, P834, DOI 10.1016/S0006-3223(97)00050-4
   Lawrence EJ, 2004, PSYCHOL MED, V34, P911, DOI 10.1017/S0033291703001624
   Le Floch R., 2006, TROUBLES EMOTIONNELS
   LOAS G, 1995, ENCEPHALE, V21, P117
   Loas G, 1996, PSYCHOPATHOLOGY, V29, P139
   Loas G, 2001, J PSYCHOSOM RES, V50, P255, DOI 10.1016/S0022-3999(01)00197-0
   Luminet O., 2003, PSYCHOPATHOLOGIE ALE, P183
   Merceron K., 2007, CARACTERISTIQUES TRO
   Muller F, 2009, CORTEX, V8, P1
   Narme P, 2010, REV NEUROPSYCHOL, V2, P292
   Nolan R, 2010, PERCEPTION AFFECTIVE
   O'Sullivan M, 1978, TESTS INTELLIGENCE S
   Peterson CC, 2009, EUR CHILD ADOLES PSY, V18, P105, DOI 10.1007/s00787-008-0711-y
   Prouteau A., 2011, NEUROPSYCHOLOGIE CLI, P135
   Sarfati Y, 1997, SCHIZOPHR RES, V25, P199, DOI 10.1016/S0920-9964(97)00025-X
   Simion A., 2006, THEORIE ESPRIT CHEZ, P2
   Speranza M, 2009, NEUROPSYCHIAT ENFAN, V57, P14, DOI 10.1016/j.neurenf.2008.05.014
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   Thomassin-Havet V., 2007, THEORIE ESPRIT LOBE
   Vieillard S, 2008, COGNITION EMOTION, V22, P750
   Vorst HCM, 2001, PERS INDIV DIFFER, V30, P413, DOI 10.1016/S0191-8869(00)00033-7
   Zanon D., 2010, LIMITES CONCEPT THEO
   Zech E, 1999, EUR J PERSONALITY, V13, P511
NR 53
TC 1
Z9 1
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0014-3855
J9 EVOL PSYCHIATR
JI Evol. Psychiatr.
PD JAN-MAR
PY 2013
VL 78
IS 1
BP 53
EP 70
DI 10.1016/j.evopsy.2013.01.002
PG 18
WC Psychiatry
SC Psychiatry
GA 127KC
UT WOS:000317696900005
ER

PT J
AU Rastam, M
   Taljemark, J
   Tajnia, A
   Lundstrom, S
   Gustafsson, P
   Lichtenstein, P
   Gillberg, C
   Anckarsater, H
   Kerekes, N
AF Rastam, Maria
   Taljemark, Jakob
   Tajnia, Armin
   Lundstrom, Sebastian
   Gustafsson, Peik
   Lichtenstein, Paul
   Gillberg, Christopher
   Anckarsater, Henrik
   Kerekes, Nora
TI Eating Problems and Overlap with ADHD and Autism Spectrum Disorders in a
   Nationwide Twin Study of 9-and 12-Year-Old Children
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID ANOREXIA-NERVOSA; TELEPHONE INTERVIEW; RISK-FACTORS; A-TAC; ADOLESCENT;
   CHILDHOOD; FOOD; SURVEILLANCE; BEHAVIORS; AD/HD
AB Aim. To establish the prevalence of restrictive eating problems, the overlap and association with attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorders (ASD) and to estimate the heritability of eating problems in a general population sample of twins aged 9 and 12. Methods. Parents of all Swedish 9- and 12-year-old twin pairs born between 1993 and 1998 (n = 12,366) were interviewed regarding symptoms of ADHD, ASD, and eating problems (EAT-P). Intraclass correlations and structural equation modelling were used for evaluating the influence of genetic and environmental factors. Cross-twin, cross-trait correlations were used to indicate a possible overlap between conditions. Results. The prevalence of eating problems was 0.6% in the study population and was significantly higher in children with ADHD and/or ASD. Among children with eating problems, 40% were screened positive for ADHD and/or ASD. Social interaction problems were strongly associated with EAT-P in girls, and impulsivity and activity problems with EAT-P in boys. The cross-twin, cross-trait correlations suggested low correlations between EAT-P and ADHD or EAT-P and ASD. Genetic effects accounted for 44% of the variation in liability for eating problems. Conclusions. In the group with eating problems, there was a clear overrepresentation of individuals with ADHD and/or ASD symptoms.
C1 [Rastam, Maria; Taljemark, Jakob; Gustafsson, Peik] Lund Univ, Dept Clin Sci, SE-22241 Lund, Sweden.
   [Tajnia, Armin; Lundstrom, Sebastian; Anckarsater, Henrik; Kerekes, Nora] Univ Gothenburg, Ctr Eth Law & Mental Hlth CELAM, SE-43141 Molndal, Sweden.
   [Lundstrom, Sebastian; Kerekes, Nora] Swedish Prison & Probat Serv, R&D Unit, SE-43141 Molndal, Sweden.
   [Lundstrom, Sebastian; Gillberg, Christopher] Univ Gothenburg, Inst Neurosci & Physiol, Gillberg Neuropsychiat Ctr, SE-41119 Gothenburg, Sweden.
   [Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17165 Solna, Sweden.
RP Rastam, M (reprint author), Lund Univ, Dept Clin Sci, Sofiavagen 2D, SE-22241 Lund, Sweden.
EM maria.rastam@med.lu.se
RI Kerekes, Nora/C-6474-2009; Taljemark, Jakob/C-1605-2015
OI Taljemark, Jakob/0000-0002-5322-3289
FU Swedish Council for Working Life and Social Research; Swedish Research
   Council (Medicine)
FX The CATSS-9/12-study is supported by the Swedish Council for Working
   Life and Social Research and the Swedish Research Council (Medicine).
   The authors have no conflict of interests including financial interests
   and relationships and affiliations relevant to the subject of this
   paper. The participants gave informed written consent.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Anckarsater H, 2012, PSYCHOL MED, V42, P1957, DOI 10.1017/S0033291711002881
   Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
   Anderluh M, 2009, PSYCHOL MED, V39, P105, DOI 10.1017/S0033291708003292
   Bandini LG, 2010, J PEDIATR-US, V157, P259, DOI 10.1016/j.jpeds.2010.02.013
   Birch LL, 1998, PEDIATRICS, V101, P539
   Bryant-Waugh R, 2010, INT J EAT DISORDER, V43, P98, DOI 10.1002/eat.20795
   Carrera O, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041851
   Connan F, 2003, PHYSIOL BEHAV, V79, P13, DOI 10.1016/S0031-9384(03)00101-X
   Cooke LJ, 2007, AM J CLIN NUTR, V86, P428
   Coombs E, 2011, BRIT J CLIN PSYCHOL, V50, P326, DOI 10.1348/014466510X524408
   Ford T, 2003, J AM ACAD CHILD PSY, V42, P1203, DOI 10.1097/01.chi.0000081820.25107.ae
   Hallerod SLH, 2010, NORD J PSYCHIAT, V64, P218, DOI 10.3109/08039480903514443
   Hannelius U, 2007, TWIN RES HUM GENET, V10, P604, DOI 10.1375/twin.10.4.604
   Jacobi C, 2004, PSYCHOL BULL, V130, P19, DOI 10.1037/0033-2909.130.1.19
   Klump KL, 2007, CURR DIR PSYCHOL SCI, V16, P37, DOI 10.1111/j.1467-8721.2007.00471.x
   Kotler LA, 2001, J AM ACAD CHILD PSY, V40, P1434, DOI 10.1097/00004583-200112000-00014
   Larson T, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-1
   Lindblad F, 2006, INT J EAT DISORDER, V39, P662, DOI 10.1002/eat.20261
   MARCHI M, 1990, J AM ACAD CHILD PSY, V29, P112, DOI 10.1097/00004583-199001000-00017
   Mazzeo SE, 2009, CHILD ADOL PSYCH CL, V18, P67, DOI 10.1016/j.chc.2008.07.003
   McGowan L, 2012, EUR J CLIN NUTR, V66, P322, DOI 10.1038/ejcn.2011.224
   Mikami AY, 2008, J ABNORM PSYCHOL, V117, P225, DOI 10.1037/0021-843X.117.1.225
   Mouridsen SE, 2008, PEDIATR INT, V50, P569, DOI 10.1111/j.1442-200X.2008.02618.x
   Neal MC, 2003, MX STAT MODELING
   Nicholls DE, 2011, BRIT J PSYCHIAT, V198, P295, DOI 10.1192/bjp.bp.110.081356
   Ntalla I., 2013, PUBLIC HEALTH NUTR, V1-8
   Patton GC, 1999, BRIT MED J, V318, P765
   Peebles R, 2006, J ADOLESCENT HEALTH, V39, P800, DOI 10.1016/j.jadohealth.2006.05.013
   Pinhas L, 2011, ARCH PEDIAT ADOL MED, V165, P895, DOI 10.1001/archpediatrics.2011.145
   RASTAM M, 1992, J AM ACAD CHILD PSY, V31, P819, DOI 10.1097/00004583-199209000-00007
   Rastam M, 2008, CLIN NEUROPSYCHIATRY, V5, P31
   Strother E., 2012, J EATING DISORDERS, V20, P346
   Sullivan PF, 2012, NAT REV GENET, V13, P537, DOI 10.1038/nrg3240
   Sullivan PF, 2002, BEHAV GENET, V32, P221, DOI 10.1023/A:1016025229858
   Wentz E, 2009, BRIT J PSYCHIAT, V194, P168, DOI 10.1192/bjp.bp.107.048686
NR 36
TC 4
Z9 4
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 315429
DI 10.1155/2013/315429
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 132SV
UT WOS:000318089900001
ER

PT J
AU McConkey, R
   Samadi, SA
AF McConkey, Roy
   Samadi, Sayyed Ali
TI The impact of mutual support on Iranian parents of children with an
   autism spectrum disorder: a longitudinal study
SO DISABILITY AND REHABILITATION
LA English
DT Article
DE Autism spectrum disorder; family support; Iran; parent education
ID INTELLECTUAL DISABILITIES; COPING STRATEGIES; SOCIAL SUPPORT;
   YOUNG-CHILDREN; MOTHERS; STRESS; INTERVENTION; METAANALYSIS;
   PERCEPTIONS; PRESCHOOL
AB Purpose: In less affluent countries with scarce professional resources, the mutual support from family and other parents may form the main assistance available to parents of children with developmental disabilities. However, few studies have attempted to promote mutual support among parents. Method: 28 mothers and fathers who attended a group-based training course on autism spectrum disorders were followed up after 12 months. Qualitative and quantitative data on parental wellbeing were gathered at three time points: before, 3 months after the course and then again 12 months later. Results: Eight parents (@30%) maintained contact with one another over the year and this grouping provided a natural experiment with those who had no further contact. All parents maintained improvements on self-rated health and family functioning but these tended to be greater for those who had maintained contact with one another. The post-training gains on parental stress had reverted to baseline levels for both groups. Conclusions: Despite opportunities to do so, most of these Iranian parents chose not to seek support from other families which may reflect cultural dispositions. Those that did so, found the contact beneficial although further training may assist with daily stresses of parenting a child with autism spectrum disorders.
C1 [McConkey, Roy; Samadi, Sayyed Ali] Univ Ulster, Inst Nursing Res, Newtownabbey BT37 0QB, North Ireland.
RP McConkey, R (reprint author), Univ Ulster, Inst Nursing Res, Newtownabbey BT37 0QB, North Ireland.
EM r.mcconkey@ulster.ac.uk
FU Health and Social Care Board for Northern Ireland
FX Roy McConkey's post is jointly funded by the Health and Social Care
   Board for Northern Ireland.
CR Abidin R. R., 1983, PARENTING STRESS IND
   Altiere MJ, 2009, J CHILD FAM STUD, V18, P83, DOI 10.1007/s10826-008-9209-y
   Bailey DB, 2007, PEDIATRICS, V120, pE992, DOI 10.1542/peds.2006-2775
   Bishop SL, 2007, AM J MENT RETARD, V112, P450, DOI 10.1352/0895-8017(2007)112[450:POPNII]2.0.CO;2
   Boyd B. A., 2002, FOCUS AUTISM OTHER D, V17, P208, DOI DOI 10.1177/10883576020170040301
   Cassidy A, 2008, EARLY CHILDHOOD DEV, V178, P115, DOI 10.1080/03004430701491721
   Chang MY, 2008, INT J DISABIL DEV ED, V55, P27, DOI 10.1080/10349120701827961
   Dabrowska A, 2010, J INTELL DISABIL RES, V54, P266, DOI 10.1111/j.1365-2788.2010.01258.x
   Daley TC, 2004, SOC SCI MED, V58, P1323, DOI 10.1016/S0277-9536(03)00330-7
   Dempsey I, 2008, TOP EARLY CHILD SPEC, V28, P42, DOI 10.1177/0271121408316699
   Dunst CJ, 2007, MENT RETARD DEV D R, V13, P370, DOI 10.1002/mrdd.20176
   Duvdevany I, 2003, J INTELL DISABIL RES, V47, P264, DOI 10.1046/j.1365-2788.2003.00488.x
   EPSTEIN NB, 1983, J MARITAL FAM THER, V9, P171, DOI 10.1111/j.1752-0606.1983.tb01497.x
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Ghazi-Moghadam S, 2009, THESIS U MINNESOTA
   Ghomri M., 2003, THESIS A TABATABAIE
   Goin-kochel R. P., 2006, J DEV DISABILITIES, V12, P41
   Goldberg D, 1999, USERS GUIDE GEN HLTH
   Guralnick M. J., 2005, DEV SYSTEMS APPROACH
   Hastings RP, 2002, J APPL RES INTELLECT, V15, P269, DOI 10.1046/j.1468-3148.2002.00104.x
   Hastings RP, 2005, AUTISM, V9, P377, DOI 10.1177/1362361305056078
   Heiman T, 2008, RES DEV DISABIL, V29, P289, DOI 10.1016/j.ridd.2007.05.005
   Homan A., 1998, NORMALIZING GEN HLTH
   Huws JC, 2001, J HEALTH PSYCHOL, V6, P569, DOI 10.1177/135910530100600509
   Keen D, 2010, RES AUTISM SPECT DIS, V4, P229, DOI 10.1016/j.rasd.2009.09.009
   Law M, 2005, CHILD CARE HLTH DEV, V31, P633, DOI 10.1111/j.1365-2214.2005.00568.x
   Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243
   Mandell DS, 2007, AUTISM, V11, P111, DOI 10.1177/1362361307077506
   McConachie H, 2007, J EVAL CLIN PRACT, V13, P120, DOI 10.1111/j.1365-2753.2006.00674.x
   McConkey R., 2010, EARLY CHILD DEV CARE, V180, P299, DOI DOI 10.1080/03004430801899187
   McConkey R, 2008, INT J NURS STUD, V45, P65, DOI 10.1016/j.ijnurstu.2006.08.007
   Montes G, 2007, PEDIATRICS, V119, pE1040, DOI 10.1542/peds.2006-2819
   Morawska A, 2006, J CONSULT CLIN PSYCH, V74, P10, DOI 10.1037/0022-006X.74.1.10
   Newell R., 2006, RES EVIDENCE BASED P
   Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
   Pisula E., 2011, COMPREHENSIVE BOOK A, P87
   Pottie CG, 2008, J FAM PSYCHOL, V22, P855, DOI 10.1037/a0013604
   Renty J, 2007, J AUTISM DEV DISORD, V37, P1247, DOI 10.1007/s10803-006-0268-x
   ROGER D, 1993, PERS INDIV DIFFER, V15, P619, DOI 10.1016/0191-8869(93)90003-L
   Samadi S, 2012, AUTISM, V16, P4
   Samadi SA, 2013, AUTISM, V17, P27, DOI 10.1177/1362361311435156
   Samadi SA, 2008, J POLICY PRACT INTEL, V5, P129, DOI 10.1111/j.1741-1130.2008.00160.x
   Samadi SA, 2012, EARLY CHILD DEV CARE, V182, P1439, DOI DOI 10.1080/03004430.2011.616931
   Samadi SA, 2012, PERSONAL IMPAC UNPUB
   Schultz TR, 2011, FOCUS AUTISM DEV DIS, V26, P96, DOI 10.1177/1088357610397346
   Singer GHS, 2006, AM J MENT RETARD, V111, P155, DOI 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2
   Skogmo P, 1995, INNOVATIONS DEV COUN, P121
   Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
   Tonge B, 2006, J AM ACAD CHILD PSY, V45, P561, DOI 10.1097/01.chi.0000205701.48324.26
   Zinkin P, 1995, DISABLED CHILDREN DE
NR 50
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0963-8288
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2013
VL 35
IS 9
BP 775
EP 784
DI 10.3109/09638288.2012.707744
PG 10
WC Rehabilitation
SC Rehabilitation
GA 118XK
UT WOS:000317060100010
PM 22900501
ER

PT J
AU Hegarty, JP
   Ferguson, BJ
   Zamzow, RM
   Christ, SE
   Mazurek, MO
   Beversdorf, DQ
AF Hegarty, John P., II
   Ferguson, Brad J.
   Zamzow, Rachel M.
   Christ, Shawn E.
   Mazurek, Micah O.
   Beversdorf, David Q.
TI CORTICAL NETWORK FLEXIBILITY DURING ADMINISTRATION OF BETA-ADRENERGIC
   ANTAGONISTS: AN AUTISM SPECTRUM DISORDER STUDY
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Hegarty, John P., II; Ferguson, Brad J.; Zamzow, Rachel M.; Christ, Shawn E.; Mazurek, Micah O.; Beversdorf, David Q.] Univ Missouri, Columbia, MO 65211 USA.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 97
EP 98
PG 2
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030500355
ER

PT J
AU Walenski, M
   Heldreth, A
   Hubbell, S
   McCabe, C
   Love, T
AF Walenski, Matthew
   Heldreth, Ashlee
   Hubbell, Stephanie
   McCabe, Connor
   Love, Tracy
TI IDIOM COMPREHENSION DURING SENTENCE PROCESSING IN CHILDREN WITH AUTISM
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Walenski, Matthew; Heldreth, Ashlee; Hubbell, Stephanie; Love, Tracy] San Diego State Univ, San Diego, CA 92182 USA.
   [Walenski, Matthew; McCabe, Connor; Love, Tracy] Univ Calif San Diego, La Jolla, CA 92093 USA.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 108
EP 108
PG 1
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030500405
ER

PT J
AU Remington, A
   Swettenham, J
   Lavie, N
AF Remington, Anna
   Swettenham, John
   Lavie, Nilli
TI INATTENTIONAL BLINDNESS AND PERCEPTUAL CAPACITY IN AUTISM SPECTRUM
   CONDITION
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Remington, Anna] Univ Oxford, Oxford OX1 2JD, England.
   [Swettenham, John; Lavie, Nilli] UCL, London WC1E 6BT, England.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 151
EP 152
PG 2
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030500609
ER

PT J
AU Remmel, R
   Van Hecke, AV
   Stevens, S
   Carson, AM
   Dolan, B
   Karst, JS
   Schohl, KA
   Fritz, N
   Kahne, J
   McDonald, G
   Reveles, A
   Wasisco, J
AF Remmel, Rheanna
   Van Hecke, Amy V.
   Stevens, Sheryl
   Carson, Audrey M.
   Dolan, Bridget
   Karst, Jeffrey S.
   Schohl, Kirsten A.
   Fritz, Noelle
   Kahne, Jenna
   McDonald, Grand
   Reveles, Alexandra
   Wasisco, Janel
TI AN EEG STUDY OF MU FREQUENCY BAND ACTIVITY IN AUTISM SPECTRUM DISORDERS
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Remmel, Rheanna; Van Hecke, Amy V.; Stevens, Sheryl; Carson, Audrey M.; Dolan, Bridget; Karst, Jeffrey S.; Schohl, Kirsten A.; Fritz, Noelle; Kahne, Jenna; McDonald, Grand; Reveles, Alexandra; Wasisco, Janel] Marquette Univ, Milwaukee, WI 53233 USA.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 159
EP 159
PG 1
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030500644
ER

PT J
AU Ferguson, B
   Zamzow, R
   Reznicek, E
   Lewis, M
   Christ, S
   Stichter, J
   Beversdorf, D
AF Ferguson, Bradley
   Zamzow, Rachel
   Reznicek, Emily
   Lewis, Morgan
   Christ, Shawn
   Stichter, Janine
   Beversdorf, David
TI EFFECTS OF BETA-ADRENERGIC ANTAGONISM ON SOCIAL INTERACTION IN AUTISM
   SPECTRUM DISORDERS
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Ferguson, Bradley; Zamzow, Rachel; Reznicek, Emily; Lewis, Morgan; Christ, Shawn; Stichter, Janine] Univ Missouri, Columbia, MO 65211 USA.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 217
EP 217
PG 1
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030501207
ER

PT J
AU Floris, D
   Chura, L
   Holt, R
   Suckling, J
   Baron-Cohen, S
   Spencer, M
AF Floris, Dorothea
   Chura, Lindsay
   Holt, Rosemary
   Suckling, John
   Baron-Cohen, Simon
   Spencer, Michael
TI ATYPICAL RIGHTWARD LATERALIZATION OF THE CORPUS CALLOSUM IS PRESENT IN
   MALES BUT NOT FEMALES WITH AUTISM.
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Floris, Dorothea; Chura, Lindsay; Holt, Rosemary; Baron-Cohen, Simon; Spencer, Michael] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Suckling, John] Univ Cambridge, Dept Psychiat, Cambridge, England.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 217
EP 217
PG 1
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030501208
ER

PT J
AU Takarae, Y
   Vieira, F
   Rezazadeh, IM
   Saron, C
AF Takarae, Yukari
   Vieira, Fernanda
   Rezazadeh, Iman Mohammad
   Saron, Clifford
TI INHIBITORY CONTROL IN AUTISM SPECTRUM DISORDERS
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Takarae, Yukari; Vieira, Fernanda; Rezazadeh, Iman Mohammad; Saron, Clifford] Univ Calif Davis, Davis, CA 95616 USA.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 219
EP 219
PG 1
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030501216
ER

PT J
AU Troiani, V
   Schultz, R
AF Troiani, Vanessa
   Schultz, Robert
TI AMYGDALA GUIDES BOTTOM-UP ATTENTION IN TYPICAL DEVELOPMENT BUT NOT IN
   AUTISM
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Troiani, Vanessa; Schultz, Robert] Univ Penn, Dept Neurosci, Philadelphia, PA 19104 USA.
   [Schultz, Robert] Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA.
   [Schultz, Robert] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
   [Troiani, Vanessa; Schultz, Robert] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA USA.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 239
EP 239
PG 1
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030501312
ER

PT J
AU Owens, E
   Kopald, B
   Ryman, S
   Demopoulos, C
   Cooper, K
   Lewine, J
AF Owens, Emmaly
   Kopald, Brandon
   Ryman, Sephira
   Demopoulos, Carly
   Cooper, Karen
   Lewine, Jeffrey
TI ANATOMICAL CORRELATES OF LANGUAGE VARIABILITY IN AUTISM
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Owens, Emmaly; Ryman, Sephira; Lewine, Jeffrey] Univ New Mexico, Albuquerque, NM 87131 USA.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 251
EP 251
PG 1
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030501369
ER

PT J
AU Yu, LD
   Fan, YB
   Deng, ZZ
   Huang, D
   Fan, Y
   Wang, SP
AF Yu, Luodi
   Fan, Yuebo
   Deng, Zhizhou
   Huang, Dan
   Fan, Yang
   Wang, Suiping
TI SUPERIOR PITCH PERCEPTION IN AUTISM? EVIDENCE OF AUDITORY MISMATCH
   NEGATIVITY FROM CHINESE
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Yu, Luodi; Deng, Zhizhou; Fan, Yang; Wang, Suiping] S China Normal Univ, Guangzhou, Guangdong, Peoples R China.
   [Fan, Yuebo; Huang, Dan] Guangzhou Cana Sch, Guangzhou Rehabil & Res Ctr Children Autism, Guangzhou, Guangdong, Peoples R China.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 252
EP 252
PG 1
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030501376
ER

PT J
AU Zamzow, RM
   Johnson, JD
   Beversdorf, DQ
   Christ, SE
AF Zamzow, Rachel M.
   Johnson, Jeffrey D.
   Beversdorf, David Q.
   Christ, Shawn E.
TI RESTING STATE FUNCTIONAL NETWORK ORGANIZATION AND TOPOLOGICAL PROPERTIES
   IN AUTISM SPECTRUM DISORDER
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Zamzow, Rachel M.; Johnson, Jeffrey D.; Beversdorf, David Q.; Christ, Shawn E.] Univ Missouri, Columbia, MO 65211 USA.
NR 0
TC 0
Z9 0
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 260
EP 260
PG 1
WC Neurosciences; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030501415
ER

PT J
AU Foster, L
   Dunn, W
   Lawson, LM
AF Foster, Lauren
   Dunn, Winnie
   Lawson, Lisa Mische
TI Coaching Mothers of Children with Autism: A Qualitative Study for
   Occupational Therapy Practice
SO PHYSICAL & OCCUPATIONAL THERAPY IN PEDIATRICS
LA English
DT Article
DE Autism; coaching; occupational therapy; qualitative study
ID PARENTS; PARTICIPATION; DISABILITIES; STRESS
AB The purpose of this study was to understand the perceptions of mothers of children with autism spectrum disorder (ASD) who participated in 10 one-hour coaching sessions. Coaching occurred between an occupational therapist and mother and consisted of information sharing, action, and reflection. Researchers asked 10 mothers six open-ended questions with follow-up probes related to their experiences with coaching. Themes were identified, labeled, and categorized. Themes emerged related to relationships, analysis, reflection, mindfulness, and self-efficacy. Findings indicate that parents perceive the therapist-parent relationship, along with analysis and reflection, as core features that facilitate increased mindfulness and self-efficacy. The findings suggest that how an intervention is provided can lead to positive outcomes, including increased mindfulness and self-efficacy.
C1 [Foster, Lauren; Dunn, Winnie; Lawson, Lisa Mische] Univ Kansas, Med Ctr, Sch Hlth Profess, Kansas City, KS 66106 USA.
RP Foster, L (reprint author), Univ Kansas, Med Ctr, Sch Hlth Profess, 3033 Robinson,Rainbow Blvd, Kansas City, KS 66106 USA.
EM lfoster@kumc.edu
FU Kansas Center for Autism Research and Training (KCART)
FX This study is part of a larger study funded by Kansas Center for Autism
   Research and Training (KCART). It was conducted as part of Lauren
   Foster's completion of her doctoral degree in occupational therapy. We
   would like to thank Dory Sabata and Jane Cox for their assistance in
   preparing this paper.
CR Bayat M, 2007, J INTELL DISABIL RES, V51, P702, DOI 10.1111/j.1365-2788.2007.00960.x
   Bedell GM, 2005, AM J OCCUP THER, V59, P273
   Case-Smith J, 2008, AM J OCCUP THER, V62, P416
   Creswell J. W., 2007, QUALITATIVE INQUIRY
   DiCicco-Bloom B, 2006, MED EDUC, V40, P314, DOI 10.1111/j.1365-2929.2006.02418.x
   Dunn W., 2009, AM OCC THER ASS PHIL
   Dunn W., 2012, AM J OCCUPATIONAL TH, V36, P520
   Dunn W, 2011, BEST PRACTICE OCCUPATIONAL THERAPY FOR CHILDREN AND FAMILIES IN COMMUNITY SETTINGS, SECOND EDITION, P1
   Dunst C. J., 2006, J POLICY PRACT INTEL, V3, P3, DOI [10.1111/j.1741-1130.2006.00047.x, DOI 10.1111/J.1741-1130.2006.00047.X]
   Egilson S. T., 2010, SCANDINAVIAN J CARIN, V25, P277
   Graham F, 2010, PHYS OCCUP THER PEDI, V30, P4, DOI 10.3109/01942630903337536
   Graham F, 2009, AUST OCCUP THER J, V56, P16, DOI 10.1111/j.1440-1630.2008.00736.x
   Grossman P, 2004, J PSYCHOSOM RES, V57, P35, DOI 10.1016/S0022-3999(03)00573-7
   Hanna K., 2002, AUSTR OCCUPATIONAL T, V49, P14, DOI DOI 10.1046/J.0045-0766.2001.00273.X
   King G, 1999, J PEDIATR PSYCHOL, V24, P41, DOI 10.1093/jpepsy/24.1.41
   King Gillian, 2003, Physical & Occupational Therapy in Pediatrics, V23, P63, DOI 10.1300/J006v23n01_05
   King Susanne, 2004, Semin Pediatr Neurol, V11, P78, DOI 10.1016/j.spen.2004.01.009
   Livescribe Inc., 2012, ECH SMARTP HARDW SOF
   McWilliam R. A., 2010, WORKING FAMILIES YOU
   Merriam S., 2002, QUALITATIVE RES PRAC
   Mezirow J., 2000, LEARNING TRANSFORMAT
   Nachshen JS, 2005, J INTELL DISABIL RES, V49, P889, DOI 10.1111/j.1365-2788.2005.00721.x
   Rosenbaum P., 1998, PHYS OCCUPATIONAL TH, V18, P1, DOI DOI 10.1300/J006V18N01_01
   Rush D. D., 2011, EARLY CHILDHOOD COAC
   Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q
   Taylor EW, 2007, INT J LIFELONG ED, V26, P173, DOI DOI 10.1080/02601370701219475
NR 26
TC 3
Z9 3
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0194-2638
J9 PHYS OCCUP THER PEDI
JI Phys. Occup. Ther. Pediatr.
PY 2013
VL 33
IS 2
BP 253
EP 263
DI 10.3109/01942638.2012.747581
PG 11
WC Pediatrics; Rehabilitation
SC Pediatrics; Rehabilitation
GA 124XU
UT WOS:000317502900009
PM 23253014
ER

PT J
AU Posserud, MB
   Lundervold, AJ
AF Posserud, Maj-Britt
   Lundervold, Astri J.
TI Mental Health Services Use Predicted by Number of Mental Health Problems
   and Gender in a Total Population Study
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; NATIONAL-COMORBIDITY-SURVEY;
   AUTISM SPECTRUM DISORDERS; DSM-IV DISORDERS; PSYCHIATRIC-DISORDERS;
   SURVEY REPLICATION; HELP-SEEKING; CHILDREN; ADHD; PREVALENCE
AB We examined the relationship between service use and the number of problem areas as reported by parents and teachers on questionnaires among children aged 7-9 years old in the Bergen Child Study, a total population study including more than 9000 children. A problem area was counted as present if the child scored above the 95th percentile on parent and/or teacher questionnaire. A total number of 13 problem areas were included. Odd ratios (ORs) for contact with child and adolescent mental health services (CAMH), school psychology services (SPS), health visiting nurse/physician, and school support were calculated with gender as covariate. The number of symptom areas was highly predictive of service use, showing a dose-response relationship for all services. Children scoring on >= 4 problem areas had a more than hundredfold risk of being in contact with CAMH services compared to children without problems. The mean number of problem areas for children in CAMH and SPS was 6.1 and 4.4 respectively, strongly supporting the ESSENCE model predicting multisymptomatology in children in specialized services. Even after controlling for number of problem areas, boys were twice as likely as girls to be in contact with CAMH, replicating previous findings of female gender being a strong barrier to mental health services.
C1 [Posserud, Maj-Britt] Haukeland Hosp, Dept Child & Adolescent Psychiat, N-5021 Bergen, Norway.
   [Posserud, Maj-Britt; Lundervold, Astri J.] Uni Res, Uni Hlth, Reg Ctr Child & Youth Mental Hlth & Child Welfare, N-5020 Bergen, Norway.
   [Lundervold, Astri J.] Univ Bergen, Dept Biol & Med Psychol, N-5020 Bergen, Norway.
   [Lundervold, Astri J.] KG Jebsen Ctr Res Neuropsychiat Disorders, N-5020 Bergen, Norway.
RP Posserud, MB (reprint author), Haukeland Hosp, Dept Child & Adolescent Psychiat, N-5021 Bergen, Norway.
EM maj-britt.posserud@uni.no
FU Western Regional Health Authorities
FX The present study was funded by the Western Regional Health Authorities.
CR Alegria M, 2004, MED CARE, V42, P447, DOI 10.1097/01.mlr.0000124248.64190.56
   American Psychiatric Association, 2011, DIAGN STAT MAN MENT
   Bussing R, 1998, AM J PUBLIC HEALTH, V88, P880, DOI 10.2105/AJPH.88.6.880
   Bussing R, 2003, J BEHAV HEALTH SER R, V30, P176, DOI 10.1007/BF02289806
   Carroll L. S., 2009, GENOME MED, V1
   Cross-Disorder Group Of The Psychiatric Genomics Consortium, 2013, LANCET
   Derks EM, 2007, TWIN RES HUM GENET, V10, P765, DOI 10.1375/twin.10.5.765
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Graetz BW, 2006, J EMOT BEHAV DISORD, V14, P2, DOI 10.1177/10634266060140010101
   Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
   Heiervang E, 2007, J AM ACAD CHILD PSY, V46, P438, DOI 10.1097/chi.0b013e31803062bf
   Jensen PS, 2001, J AM ACAD CHILD PSY, V40, P147, DOI 10.1097/00004583-200102000-00009
   Kazdin AE, 2006, J CONSULT CLIN PSYCH, V74, P455, DOI 10.1037/0022-006X.74.3.455
   KESSLER RC, 1994, ARCH GEN PSYCHIAT, V51, P8
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P617, DOI 10.1001/archpsyc.62.6.617
   Kopp S, 2010, J ATTEN DISORD, V14, P167, DOI 10.1177/1087054709332458
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   Mulder RT, 2003, AUST NZ J PSYCHIAT, V37, P265, DOI 10.1046/j.1440-1614.2003.01176.x
   Ohan JL, 2009, J CLIN CHILD ADOLESC, V38, P650, DOI 10.1080/15374410903103627
   Pisecco S, 2001, J CLIN CHILD PSYCHOL, V30, P413, DOI 10.1207/S15374424JCCP3003_12
   Posserud MB, 2006, J CHILD PSYCHOL PSYC, V47, P167, DOI 10.1111/j.1469-7610.2005.01462.x
   Rommelse NNJ, 2010, EUR CHILD ADOLES PSY, V19, P281, DOI 10.1007/s00787-010-0092-x
   Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x
   Sawyer MG, 2004, J AM ACAD CHILD PSY, V43, P1355, DOI 10.1097/01.chi.0000138354.90981.5b
   Stahlberg O, 2004, J NEURAL TRANSM, V111, P891, DOI 10.1007/s00702-004-0115-1
   Stormark KM, 2008, J ABNORM CHILD PSYCH, V36, P411, DOI 10.1007/s10802-007-9187-3
   Ullebo AK, 2012, SOC PSYCH PSYCH EPID, V47, P763, DOI 10.1007/s00127-011-0379-3
   van Widenfelt BM, 2003, EUR CHILD ADOLES PSY, V12, P281, DOI 10.1007/s00787-003-0341-3
   WOODS DJ, 1979, J CLIN PSYCHOL, V35, P912, DOI 10.1002/1097-4679(197910)35:4<912::AID-JCLP2270350445>3.0.CO;2-F
NR 30
TC 1
Z9 1
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 247283
DI 10.1155/2013/247283
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 125AY
UT WOS:000317511700001
ER

PT J
AU Rosenkranz, P
   Charlton, BG
AF Rosenkranz, Patrick
   Charlton, Bruce G.
TI Individual Differences in Existential Orientation: Empathizing and
   Systemizing Explain the Sex Difference in Religious Orientation and
   Science Acceptance
SO ARCHIVE FOR THE PSYCHOLOGY OF RELIGION-ARCHIV FUR RELIGIONSPSYCHOLOGIE
LA English
DT Article
DE atheism; theism; sex difference; existential orientation;
   empathizing-systemizing
ID HIGH-FUNCTIONING AUTISM; GENDER DIFFERENCES; ASPERGER-SYNDROME; 5-FACTOR
   MODEL; PERSONALITY; SPIRITUALITY; ADULTS; QUOTIENT; BRAIN; MASCULINITY
AB On a wide range of measures and across cultures and societies, women tend to be more religious than men. Religious beliefs are associated with evolved social-cognitive mechanisms such as agency detection and theory-of-mind. Women perform better on most of these components of social cognition, suggesting an underlying psychological explanation for these sex differences. The Existential Orientation Scale was developed to extend the measurement of religion to include non-religious beliefs (Study 1). Factor analysis extracted two dimensions: religious orientation and science acceptance. This new scale was used to investigate the hypothesis that the dimensions of empathizing, a measure of social cognition, and systemizing can explain the sex differences in religious orientation (Study 2). The sex differences in both religious orientation and science acceptance disappeared when empathizing and systemizing were entered. This indicates that underlying dimensions of individual differences can explain existential orientation better than being male or female.
C1 [Rosenkranz, Patrick; Charlton, Bruce G.] Newcastle Univ, Sch Psychol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
RP Rosenkranz, P (reprint author), Newcastle Univ, Sch Psychol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
EM patrick.rosenkranz@nd.ac.uk; bruce.charlton@nd.ac.uk
RI Rosenkranz, Patrick/H-7352-2013
OI Rosenkranz, Patrick/0000-0003-0751-8833
CR Argyle Michael, 1975, SOCIAL PSYCHOL RELIG
   Atran S., 2004, BEHAV BRAIN SCI, V27, P1
   Bainbridge W.S., 2005, INTERDISCIPLINARY J, V1, P1
   Baron-Cohen S., 2002, HDB COGNITIVE DEV, P491
   Baron-Cohen S., 2003, ESSENTIAL DIFFERENCE
   Baron-Cohen S., 2005, ORIGINS SOCIAL MIND
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Barrett JL, 2000, TRENDS COGN SCI, V4, P29, DOI 10.1016/S1364-6613(99)01419-9
   Barrett Justin L., 2004, WHY WOULD ANYONE BEL
   Batson C. D., 1993, RELIG INDIVIDUAL SOC
   Beit-Hallahmi Benjamin, 1997, PSYCHOL RELIG BEHAV
   BEM SL, 1981, PSYCHOL REV, V88, P354, DOI 10.1037/0033-295X.88.4.354
   Bering J. M., 2005, ORIGINS SOCIAL MIND, P411
   Boyer P, 2003, TRENDS COGN SCI, V7, P119, DOI 10.1016/S1364-6613(03)00031-7
   Boyer P, 2001, COGNITIVE SCI, V25, P535, DOI 10.1207/s15516709cog2504_2
   Boyer Pascal, 2002, RELIG EXPLAINED HUMA
   Boyer Pascal, 2001, DEBATED MIND EVOLUTI, P57
   Brace N., 2006, SPSS PSYCHOL
   Buchanan T, 2005, EUR J PSYCHOL ASSESS, V21, P115, DOI 10.1027/1015-5759.21.2.115
   Bulbulia J, 2004, BIOL PHILOS, V19, P655, DOI 10.1007/s10539-005-5568-6
   Byrne R. W., 1988, MACHIAVELLIAN INTELL
   Caldwell-Harris Catherine L, 2012, RELIG BRAIN BEHAV, V2, P4
   Charlton B., 2001, WHAT IS MEANING LIFE
   COSTA PT, 1992, PERS INDIV DIFFER, V13, P653, DOI 10.1016/0191-8869(92)90236-I
   Dennett D., 2003, BRIGHT STUFF
   Dennett Daniel, 2006, BREAKING SPELL RELIG
   DEVAUS D, 1987, AM SOCIOL REV, V52, P472, DOI 10.2307/2095292
   DIGMAN JM, 1990, ANNU REV PSYCHOL, V41, P417, DOI 10.1146/annurev.psych.41.1.417
   Dunbar RIM, 1998, EVOL ANTHROPOL, V6, P178, DOI 10.1002/(SICI)1520-6505(1998)6:5<178::AID-EVAN5>3.0.CO;2-8
   DUNBAR RIM, 1995, J HUM EVOL, V28, P287, DOI 10.1006/jhev.1995.1021
   Eysenck Hans J., 1976, PSYCHOTICISM DIMENSI
   Fowler R. L., 1987, APPL PSYCHOL MEASURE, V11
   FRANCIS LJ, 1992, PERS INDIV DIFFER, V13, P645, DOI 10.1016/0191-8869(92)90235-H
   Francis LJ, 1997, RELIGION, V27, P81, DOI 10.1006/reli.1996.0066
   Frith U., 2005, CURR BIOL, V15, P786
   Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
   Gardner P, 1995, RES SCI EDUC, V25, P283, DOI [10. 1007/ BF02357402, DOI 10.1007/BF02357402]
   Glock Charles Y., 1967, COMFORT CHALLENGE DI
   GOLDBERG LR, 1993, AM PSYCHOL, V48, P26, DOI 10.1037//0003-066X.48.1.26
   GORSUCH RL, 1984, AM PSYCHOL, V39, P228, DOI 10.1037//0003-066X.39.3.228
   Grassby J., 2005, POSTMODERN HUMANISM
   Guthrie Stewart Eliott, 1993, FACES CLOUDS
   Hill P. C., 2005, HDB PSYCHOL RELIG SP, P43
   Hill PC, 2000, J THEOR SOC BEHAV, V30, P51, DOI 10.1111/1468-5914.00119
   Hill PC, 1999, MEASURES RELIG
   Hobson A., 2000, MODERN HUMANISM LIVI
   Humphrey N., 1976, MACHIAVELLIAN INTELL, P13
   IANNACCONE LR, 1990, J SCI STUD RELIG, V29, P297, DOI 10.2307/1386460
   Jagodzinski W., DEMAND RELIG HARD CO
   Kapogiannis D, 2009, P NATL ACAD SCI USA, V106, P4876, DOI 10.1073/pnas.0811717106
   King Bruce, 2003, STAT REASONING PSYCH
   Lawson J, 2004, J AUTISM DEV DISORD, V34, P301, DOI 10.1023/B:JADD.0000029552.42724.1b
   Lee Lois, 2012, J CONT RELIG, V27, P129, DOI DOI 10.1080/13537903.2012.642742
   Lippa RA, 2001, J RES PERS, V35, P168, DOI 10.1006/jrpe.2000.2307
   Loewenthal KM, 2001, INTRO PSYCHOL TESTS
   MacDonald D. A., 2000, EXPRESSION SPI UNPUB
   MacDonald DA, 2000, J PERS, V68, P153, DOI 10.1111/1467-6494.00094
   Martin M, 2007, CAMBR COMPANION PHIL, P217, DOI 10.1017/CCOL0521842700.014
   McCauley R. N., 2000, EXPLANATION COGNITIO, P61
   MILLER AS, 1995, J SCI STUD RELIG, V34, P63, DOI 10.2307/1386523
   Miller WR, 2003, AM PSYCHOL, V58, P24, DOI 10.1037/0003-066X.58.1.24
   Mol H., 1985, FAITH AUSTR
   Muncer SJ, 2006, PERS INDIV DIFFER, V40, P1111, DOI 10.1016/j.paid.2005.09.020
   Nettle D., 2007, BRIT J PSYCHOL, V00, P1
   Nettle D, 2006, AM PSYCHOL, V61, P622, DOI 10.1037/0003-066X.61.6.622
   Nettle D, 2008, EUR J PERSONALITY, V22, P323, DOI 10.1002/per.672
   Pyysaiinen I, 2003, RELIGION, V33, P341, DOI 10.1016/j.religion.2003.09.001
   Pyysiainen Ilkka, 2001, RELIG WORKS NEW COGN
   Riley J., 2005, EXISTENTIAL CONVICTI
   Saler B., 2006, TEMENOS, V42, P7
   Saroglou V, 2002, PERS INDIV DIFFER, V32, P15, DOI 10.1016/S0191-8869(00)00233-6
   Saroglou V, 2010, PERS SOC PSYCHOL REV, V14, P108, DOI 10.1177/1088868309352322
   SCHENK J, 1986, PERS INDIV DIFFER, V7, P161, DOI 10.1016/0191-8869(86)90051-6
   Schjoedt U, 2009, SOC COGN AFFECT NEUR, V4, P199, DOI 10.1093/scan/nsn050
   Smart N., 1989, WORLDS RELIG
   Spilka B, 2003, PSYCHOL RELIG EMPIRI
   Stark R, 2002, J SCI STUD RELIG, V41, P495, DOI 10.1111/1468-5906.00133
   SULLIVAN LM, 1992, J DENT RES, V71, P1938, DOI 10.1177/00220345920710121601
   THOMPSON EH, 1991, J SCI STUD RELIG, V30, P381, DOI 10.2307/1387275
   VERNON GM, 1968, J SCI STUD RELIG, V7, P219, DOI 10.2307/1384629
   Wakabayashi A, 2007, J AUTISM DEV DISORD, V37, P1823, DOI 10.1007/s10803-006-0316-6
   WELCH BL, 1951, BIOMETRIKA, V38, P330, DOI 10.2307/2332579
   Zinnbauer B. J., 1999, J PERS, V67, P887
   Zinnbauer BJ, 1997, J SCI STUD RELIG, V36, P549, DOI 10.2307/1387689
NR 86
TC 0
Z9 0
PU BRILL ACADEMIC PUBLISHERS
PI LEIDEN
PA PLANTIJNSTRAAT 2, P O BOX 9000, 2300 PA LEIDEN, NETHERLANDS
SN 0084-6724
J9 ARCH PSYCHOL RELIG
JI Arch. Psychol. Relig.
PY 2013
VL 35
IS 1
BP 119
EP 146
DI 10.1163/15736121-12341255
PG 28
WC Psychology, Multidisciplinary; Religion
SC Psychology; Religion
GA 120GF
UT WOS:000317158100006
ER

PT J
AU Stewart, ME
   McAdam, C
   Ota, M
   Peppe, S
   Cleland, J
AF Stewart, Mary E.
   McAdam, Clair
   Ota, Mitsuhiko
   Peppe, Sue
   Cleland, Joanne
TI Emotional recognition in autism spectrum conditions from voices and
   faces
SO AUTISM
LA English
DT Article
DE Emotion; autism spectrum conditions; prosody; vocal emotion
ID HIGH-FUNCTIONING AUTISM; FACIAL EXPRESSION; ASPERGER-SYNDROME; NORMAL
   ADULTS; CHILDREN; MIND; PROSODY; PERCEPTION; DISORDERS
AB The present study reports on a new vocal emotion recognition task and assesses whether people with autism spectrum conditions (ASC) perform differently from typically developed individuals on tests of emotional identification from both the face and the voice. The new test of vocal emotion contained trials in which the vocal emotion of the sentence were congruent, incongruent, or neutral with respect to the semantic content. We also included a condition in which there was no semantic content (an 'mmm' was uttered using an emotional tone). Performance was compared between 11 adults with ASC and 14 typically developed adults. Identification of emotion from sentences in which the vocal emotion and the meaning of sentence were congruent was similar in people with ASC and a typically developed comparison group. However, the comparison group was more accurate at identifying the emotion in the voice from incongruent and neutral trials, and also from trials with no semantic content. The results of the vocal emotion task were correlated with performance on a face emotion recognition task. In decoding emotion from spoken utterances, individuals with ASC relied more on verbal semantics than did typically developed individuals, presumably as a strategy to compensate for their difficulties in using prosodic cues to recognize emotions.
C1 [Stewart, Mary E.; McAdam, Clair] Heriot Watt Univ, Edinburgh EH14 4AS, Midlothian, Scotland.
   [Ota, Mitsuhiko] Univ Edinburgh, Edinburgh EH8 9AD, Midlothian, Scotland.
   [Peppe, Sue; Cleland, Joanne] Queen Margaret Univ, Edinburgh EH21 6UU, Midlothian, Scotland.
RP Stewart, ME (reprint author), Heriot Watt Univ, Edinburgh EH14 4AS, Midlothian, Scotland.
EM M.E.Stewart@hw.ac.uk
CR [Anonymous], J AUTISM DEV DISORDE, V36, P169
   Balconi M, 2007, RES DEV DISABIL, V28, P409, DOI 10.1016/j.ridd.2006.05.001
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Boucher J, 1998, J CHILD PSYCHOL PSYC, V39, P171, DOI 10.1017/S0021963097001820
   CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x
   Dyck MJ, 2001, EUR CHILD ADOLES PSY, V10, P105
   EKMAN P, 1993, AM PSYCHOL, V48, P384, DOI 10.1037//0003-066X.48.4.384
   Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5
   Golan O, 2006, CAMBRIDGE MINDREADIN
   Grossman JB, 2000, J CHILD PSYCHOL PSYC, V41, P369, DOI 10.1017/S0021963099005466
   Hobson R. P., 1989, ABILITIES DISABILITI, V1, P237
   Humphreys K, 2007, NEUROPSYCHOLOGIA, V45, P685, DOI 10.1016/j.neuropsychologia.2006.08.003
   Kleinman J, 2001, J AUTISM DEV DISORD, V31, P29, DOI 10.1023/A:1005657512379
   Lindner JL, 2006, J AUTISM DEV DISORD, V36, P769, DOI 10.1007/s10803-006-0105-2
   LOVELAND KA, 1995, DEV PSYCHOPATHOL, V7, P409
   Lyons MJ, 1999, IEEE T PATTERN ANAL, V21, P1357, DOI 10.1109/34.817413
   MEHRABIA.A, 1967, J PERS SOC PSYCHOL, V6, P109, DOI 10.1037/h0024532
   Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9
   Peppe S, 2007, J SPEECH LANG HEAR R, V50, P1015, DOI 10.1044/1092-4388(2007/071)
   Raven JC, 1998, SECT 4 ADV PROGR MAT
   Rutherford MD, 2002, J AUTISM DEV DISORD, V32, P189, DOI 10.1023/A:1015497629971
   VANLANCKER D, 1989, DEV NEUROPSYCHOL, V5, P207
   Wang AT, 2006, BRAIN, V129, P932, DOI 10.1093/brain/awl032
   Wechsler D., 1992, WECHSLER INTELLIGENC
NR 24
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JAN
PY 2013
VL 17
IS 1
BP 6
EP 14
DI 10.1177/1362361311424572
PG 9
WC Psychology, Developmental
SC Psychology
GA 118ZM
UT WOS:000317066100002
PM 23045218
ER

PT J
AU Kamio, Y
   Inada, N
   Koyama, T
AF Kamio, Yoko
   Inada, Naoko
   Koyama, Tomonori
TI A nationwide survey on quality of life and associated factors of adults
   with high-functioning autism spectrum disorders
SO AUTISM
LA English
DT Article
DE high-functioning autism spectrum disorder; quality of life; adult;
   outcome; early diagnosis
ID ASPERGER-SYNDROME; FOLLOW-UP; CHILDREN; DIAGNOSIS; MEN
AB The psychosocial outcomes of individuals with high-functioning autism spectrum disorder (HFASD) appear to be diverse and are often poor relative to their intellectual or language level. To identify predictive variables that are potentially ameliorable by therapeutic intervention, this study investigated self-reported psychosocial quality of life and associated factors for adults with HFASD. All participants (n = 154) had a diagnosis of autism spectrum disorder, were over 18 years of age, lived in the community, and had used one or more support services during the survey period. The results demonstrated that psychosocial quality of life was lower than that of the general Japanese adult population. Environmental factors, such as mother's support and early diagnosis, were associated with better quality of life, and aggressive behaviors were associated with poorer quality of life, while expressive language level at preschool years, a conventional outcome predictor, did not predict quality of life. These results emphasize that quality of life measures should be included as outcome indicators in treating individuals with HFASD.
C1 [Kamio, Yoko; Inada, Naoko; Koyama, Tomonori] Natl Ctr Neurol & Psychiat, Kodaira, Tokyo 1878553, Japan.
RP Kamio, Y (reprint author), Natl Ctr Neurol & Psychiat, Dept Child & Adolescent Mental Hlth, Natl Inst Mental Hlth, 4-1-1 Ogawa Higashi Cho, Kodaira, Tokyo 1878553, Japan.
EM kamio@ncnp.go.jp
CR Bastiaansen D, 2004, J AM ACAD CHILD PSY, V43, P221, DOI 10.1097/01.chi.0000102684.30206.ad
   Bastiaansen D, 2005, EUR CHILD ADOLES PSY, V14, P364, DOI 10.1007/s00787-005-0481-8
   Doi T, 1973, ANATOMY DEPENDENCE
   Fountain C, 2011, J EPIDEMIOL COMMUN H, V65, P503, DOI 10.1136/jech.2009.104588
   Gerber F, 2008, J AUTISM DEV DISORD, V38, P1654, DOI 10.1007/s10803-008-0547-9
   Honda H, 2005, DEV MED CHILD NEUROL, V47, P10, DOI 10.1017/S0012162205000034
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Jennes-Coussens M, 2006, AUTISM, V10, P403, DOI 10.1177/1362361306064432
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Kamio Y, 2011, OXFORD HDB SOCIAL NE, P848
   Kamio Y, 2009, J JAPANESE ASS PSYCH, V28, P14
   Kamp-Becker I, 2010, GMS PSYCHOSOCIA 0831, P7
   KOBAYASHI R, 1992, J AUTISM DEV DISORD, V22, P395, DOI 10.1007/BF01048242
   Koyama T, 2009, ANN REPORT RES SUPPO
   Kuhlthau K, 2010, J AUTISM DEV DISORD, V40, P721, DOI 10.1007/s10803-009-0921-2
   Landa RJ, 2008, NAT CLIN PRACT NEURO, V4, P138, DOI 10.1038/ncpneuro0731
   Mawhood L, 2000, J CHILD PSYCHOL PSYC, V41, P547, DOI 10.1017/S002196309900579X
   Ministry of Education Culture Sports Science and Technology, 2009, SCH BASIC SURV 2009
   Nakane Y, 1999, IRYO TO SHAKAI, V9, P123
   National Institute of Population and Social Security Research, 2007, REP 13 JAP NAT FERT, VII
   Persson B, 2000, J AUTISM DEV DISORD, V30, P61, DOI 10.1023/A:1005464128544
   Renty J, 2006, AUTISM, V10, P511, DOI 10.1177/1362361306066604
   Ruble L. A., 1996, FOCUS AUTISM OTHER D, V11, P3
   Saldana D, 2009, AUTISM, V13, P303, DOI 10.1177/1362361309103792
   Tantam D., 2000, ASPERGER SYNDROME, P367
   Tazaki M, 2007, WHOQOL26 TEB KAIT
   KUYKEN W, 1995, SOC SCI MED, V41, P1403
   Tsatsanis KD, 2003, CHILD ADOL PSYCH CL, V12, P47, DOI 10.1016/S1056-4993(02)00056-1
NR 28
TC 8
Z9 8
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JAN
PY 2013
VL 17
IS 1
BP 15
EP 26
DI 10.1177/1362361312436848
PG 12
WC Psychology, Developmental
SC Psychology
GA 118ZM
UT WOS:000317066100003
PM 22399449
ER

PT J
AU Samadi, SA
   McConkey, R
   Kelly, G
AF Samadi, Sayyed Ali
   McConkey, Roy
   Kelly, Greg
TI Enhancing parental well-being and coping through a family-centred short
   course for Iranian parents of children with an autism spectrum disorder
SO AUTISM
LA English
DT Article
DE Parent education; family support; autism spectrum disorder; Iran
ID INTELLECTUAL DISABILITIES; EARLY INTERVENTION; YOUNG-CHILDREN;
   DOWN-SYNDROME; MOTHERS; STRESS; DIAGNOSIS; EDUCATION; STYLES; NEEDS
AB Parents of children with Autism Spectrum Disorders (ASD) generally experience high levels of stress and report poorer emotional well-being and family functioning compared to parents of children with other disabilities. They also tend to rely on emotional rather than problem-focused coping strategies. Seven group-based sessions were offered to two groups of parents of children with ASD in Iran (37 in all). In addition to providing information about ASD emphasis was placed on families sharing their experiences and learning from one another. A pre-post, cross-over design was used to evaluate the specific impact of the course. The changes found among the parents in the first group were replicated with the second group. Moreover the changes were sustained up to 15 weeks after the course ended. Although there were variations across the parents, in general they reported feeling less stress, had better emotional wellbeing and family functioning and made more use of problem-focused coping strategies. The changes were attributed mainly to an increase in the informal supports among the parents and their feelings of empowerment. A resource pack has been developed to enable the group sessions to be easily repeated and for facilitators to be trained in its use.
C1 [Samadi, Sayyed Ali; McConkey, Roy] Univ Ulster, Inst Nursing Res, Newtownabbey BT37 0QB, North Ireland.
   [Kelly, Greg] Univ Ulster, Sch Hlth Sci, Newtownabbey BT37 0QB, North Ireland.
RP McConkey, R (reprint author), Univ Ulster, Inst Nursing Res, Newtownabbey BT37 0QB, North Ireland.
EM r.mcconkey@ulster.ac.uk
CR Abidin R. R., 1983, PARENTING STRESS IND
   Altiere MJ, 2009, J CHILD FAM STUD, V18, P83, DOI 10.1007/s10826-008-9209-y
   Bailey DB, 2005, INT ISSUE EARLY INTE, P151
   Baker-Ericzen MJ, 2005, RES PRACT PERS SEV D, V30, P194, DOI 10.2511/rpsd.30.4.194
   Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0
   Beresford B, 1995, J CHILD PSYCHOL PSYC, V35, P171
   Bilgin Hulya, 2010, J Child Adolesc Psychiatr Nurs, V23, P92, DOI 10.1111/j.1744-6171.2010.00228.x
   Brookman-Frazee L, 2006, CLIN CHILD FAM PSYCH, V9, P81
   Carey J. W., 1993, QUALITATIVE HLTH RES, V3, P298, DOI 10.1177/104973239300300303
   CHESNEY BK, 1993, SMALL GR RES, V24, P258, DOI 10.1177/1046496493242006
   Dabrowska A, 2010, J INTELL DISABIL RES, V54, P266, DOI 10.1111/j.1365-2788.2010.01258.x
   Daley TC, 2004, SOC SCI MED, V58, P1323, DOI 10.1016/S0277-9536(03)00330-7
   Dempsey I, 2004, J INTELLECT DEV DIS, V29, P40, DOI 10.1080/13668250410001662874
   Dempsey I, 2008, TOP EARLY CHILD SPEC, V28, P42, DOI 10.1177/0271121408316699
   Dunn ME, 2001, COMMUNITY MENT HLT J, V37, P39, DOI 10.1023/A:1026592305436
   Dunst CJ, 2007, MENT RETARD DEV D R, V13, P370, DOI 10.1002/mrdd.20176
   EPSTEIN NB, 1983, J MARITAL FAM THER, V9, P171, DOI 10.1111/j.1752-0606.1983.tb01497.x
   Farrugia D, 2009, SOCIOL HEALTH ILL, V31, P1011, DOI 10.1111/j.1467-9566.2009.01174.x
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Ghomri M, 2003, THESIS ALLAMEH TABAT
   Gilliam J. E., 1995, GILLIAM AUTISM RATIN
   Goldberg D., 1991, USERS GUIDE GEN HLTH
   Gorman CJC, 1997, REV EDUC RES, V67, P339
   Guralnick M. J., 2005, DEV SYSTEMS APPROACH
   Hastings RP, 2002, J APPL RES INTELLECT, V15, P269, DOI 10.1046/j.1468-3148.2002.00104.x
   Hastings RP, 2001, J AUTISM DEV DISORD, V31, P62
   Hastings RP, 2005, AUTISM, V9, P377, DOI 10.1177/1362361305056078
   Hatton C., 2004, SUPPORTING S ASIAN F
   Homan A, 1998, NORMALIZING GEN QUES
   Hornby Gary, 2000, IMPROVING PARENTAL I
   Kaiser AP, 2003, INFANT YOUNG CHILD, V16, P9
   Keen D, 2010, RES AUTISM SPECT DIS, V4, P229, DOI 10.1016/j.rasd.2009.09.009
   Khoshabi K, 2003, 5 NAT C CHILDR INT D
   Krug D. A, 1978, AUTISM DIAGNOSIS INS
   Kuhn JC, 2006, AM J ORTHOPSYCHIAT, V76, P564, DOI 10.1037/0002-9432.76.4.564
   Mak WWS, 2010, SOC SCI MED, V70, P2045, DOI 10.1016/j.socscimed.2010.02.023
   Matson ML, 2009, RES AUTISM SPECT DIS, V3, P868, DOI 10.1016/j.rasd.2009.02.003
   McConachie H, 2005, J PEDIATR-US, V147, P335, DOI 10.1016/j.jpeds.2005.03.056
   McConkey R., 2010, EARLY CHILD DEV CARE, V180, P299, DOI DOI 10.1080/03004430801899187
   McConkey R, 2008, INT J NURS STUD, V45, P65, DOI 10.1016/j.ijnurstu.2006.08.007
   Montes G, 2007, PEDIATRICS, V119, P1040, DOI DOI 10.1542/PEDS.2006-2819
   Nachshen J., 2000, DEV DISABILITIES B, V28, P39
   Nelson LGL, 2004, REM SPEC EDUC, V25, P153
   Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7
   Pakenham KI, 2004, RES DEV DISABIL, V25, P245, DOI 10.1016/j.ridd.2003.06.003
   Pottie CG, 2008, J FAM PSYCHOL, V22, P855, DOI 10.1037/a0013604
   Probst P, 2001, OUTCOMES GROUP PAREN
   ROGER D, 1993, PERS INDIV DIFFER, V15, P619, DOI 10.1016/0191-8869(93)90003-L
   Runswick-Cole K, 2007, DISABIL SOC, V22, P315, DOI 10.1080/09687590701259674
   Ryan S, 2009, J APPL RES INTELLECT, V22, P43, DOI 10.1111/j.1468-3148.2008.00438.x
   Sabih S, 2008, RAWALPINDI MED J, V33, P214
   Samadi SA, 2011, AUTISM INT J RES PRA, V2011, DOI [10.1177/1362361311407091, DOI 10.1177/1362361311407091]
   Samadi SA, 2008, J POLICY PRACT INTEL, V5, P129, DOI 10.1111/j.1741-1130.2008.00160.x
   Samadi SA, 2012, EARLY CHILD DEV CARE, V182, P1439, DOI DOI 10.1080/03004430.2011.616931
   Sanders JL, 1997, CHILD FAM BEHAV THER, V19, P15, DOI 10.1300/J019v19n04_02
   Schultz TR, 2011, FOCUS AUTISM DEV DIS, V26, P96, DOI 10.1177/1088357610397346
   Shields J, 2001, AUTISM, V5, P49, DOI 10.1177/1362361301005001005
   Singh NN, 2007, BEHAV MODIF, V31, P749, DOI 10.1177/0145445507300924
   Sivberg B, 2002, AUTISM, V6, P397, DOI 10.1177/1362361302006004006
   Smith LE, 2010, J AUTISM DEV DISORD, V40, P167, DOI 10.1007/s10803-009-0844-y
   Solomon R, 2007, AUTISM, V11, P205, DOI 10.1177/1362361307076842
   Thompson L, 1997, EXCEPT CHILDREN, V64, P99
   Turnbull A., 2010, FAMILIES PROFESSIONA
   UNESCO, 2011, UIS STAT BRIEF ED AL
   Wachtel K, 2008, AUTISM, V12, P575, DOI 10.1177/1362361308094505
   Walker SK, 2001, FAM RELAT, V50, P186, DOI 10.1111/j.1741-3729.2001.00186.x
   Welterlin A, 2007, DISABIL SOC, V22, P747, DOI 10.1080/09687590701659600
   Zinkin P, 1995, DISABLED CHILDREN DE
NR 68
TC 5
Z9 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JAN
PY 2013
VL 17
IS 1
BP 27
EP 43
DI 10.1177/1362361311435156
PG 17
WC Psychology, Developmental
SC Psychology
GA 118ZM
UT WOS:000317066100004
PM 22297201
ER

PT J
AU Bandini, LG
   Gleason, J
   Curtin, C
   Lividini, K
   Anderson, SE
   Cermak, SA
   Maslin, M
   Must, A
AF Bandini, Linda G.
   Gleason, James
   Curtin, Carol
   Lividini, Keith
   Anderson, Sarah E.
   Cermak, Sharon A.
   Maslin, Melissa
   Must, Aviva
TI Comparison of physical activity between children with autism spectrum
   disorders and typically developing children
SO AUTISM
LA English
DT Article
DE accelerometry; children; physical activity; autism spectrum disorders
ID YOUTH; WEIGHT; HEALTH
AB Regular physical activity is important for promoting health and well-being; however, physical activity behaviors in children with autism spectrum disorders (ASD) have received little attention. We compared physical activity levels among 53 children with ASD and 58 typically developing children aged 3-11 years who participated in the Children's Activity and Meal Patterns Study (CHAMPS). After adjustment for age and sex the amount of time spent daily in moderate and vigorous activity was similar in children with ASD (50.0 minutes/day and typically developing children 57.1 minutes/day). However, parents reported that children with ASD participated in significantly fewer types of physical activities than did typically developing children (6.9 vs. 9.6, p < .0001) and spent less time annually participating in these activities than typically developing children (158 vs. 225 hours per year, p < 0.0001) after adjusting for age and sex. Although both groups of children engaged in similar levels of moderate and vigorous activity as measured by accelerometry, children with ASD engaged in fewer physical activities and for less time according to parental report, suggesting that some of the activity in children with ASD is not captured by standard questionnaire-based measures.
C1 [Bandini, Linda G.; Gleason, James; Curtin, Carol; Maslin, Melissa] Univ Massachusetts, Eunice Kennedy Shriver Ctr, Sch Med, Waltham, MA 02452 USA.
   [Bandini, Linda G.] Boston Univ, Dept Hlth Sci, Boston, MA 02215 USA.
   [Lividini, Keith] IFPRI, HarvestPlus, Washington, DC USA.
   [Anderson, Sarah E.] Ohio State Univ, Div Epidemiol, Coll Publ Hlth, Columbus, OH 43210 USA.
   [Cermak, Sharon A.] Univ So Calif, Div Occupat Sci & Occupat Therapy, Los Angeles, CA USA.
   [Must, Aviva] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA.
RP Bandini, LG (reprint author), Univ Massachusetts, Eunice Kennedy Shriver Ctr, Sch Med, 200 Trapelo Rd, Waltham, MA 02452 USA.
EM linda.bandini@umassmed.edu
CR Blanchard LT, 2006, PEDIATRICS, V117, pE1202, DOI 10.1542/peds.2005-2606
   CDC, 2011, PHYS ACT EV CHILDR
   CDC, 2003, NAT HLTH NUTR EX SUR
   CDC Division of Nutrition Physical Activity and Obesity, 2011, HLTH WEIGHT ASSESSIN
   Elliott C. D., 1990, DIFFERENTIAL ABILITY
   Green D, 2009, DEV MED CHILD NEUROL, V51, P311, DOI 10.1111/j.1469-8749.2008.03242.x
   Janssen I, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-40
   Kuczmarski R. J., 2002, VITAL HLTH STAT, V11, P1
   Must A, 2005, INT J OBESITY, V29, pS84, DOI 10.1038/sj.ijo.0803064
   Pan CY, 2008, J AUTISM DEV DISORD, V38, P1292, DOI 10.1007/s10803-007-0518-6
   Pan CY, 2006, J AUTISM DEV DISORD, V36, P597, DOI 10.1007/s10803-006-0101-6
   Pan CY, 2005, J PHYS ACT HEALTH, V2, P412
   Puyau MR, 2004, MED SCI SPORT EXER, V36, P1625, DOI 10.1249/01.MSS.0000139898.30804.60
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Sandt DDR, 2005, ADAPT PHYS ACT Q, V22, P146
   Schmalz DL, 2007, J ADOLESCENT HEALTH, V41, P559, DOI 10.1016/j.jadohealth.2007.07.001
   Spadano JL, 2003, INT J OBESITY, V27, P1528, DOI 10.1038/sj.ijo.0802440
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Troiano RP, 2008, MED SCI SPORT EXER, V40, P181, DOI 10.1249/mss.0b013e31815a51b3
   Venkatesan S, 2005, ASIA PACIFIC DISABIL, V16, P68
NR 20
TC 2
Z9 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JAN
PY 2013
VL 17
IS 1
BP 44
EP 54
DI 10.1177/1362361312437416
PG 11
WC Psychology, Developmental
SC Psychology
GA 118ZM
UT WOS:000317066100005
PM 22807562
ER

PT J
AU Mouridsen, SE
   Isager, T
   Rich, B
AF Mouridsen, Svend Erik
   Isager, Torben
   Rich, Bente
TI Diseases of the gastrointestinal tract in individuals diagnosed as
   children with atypical autism: A Danish register study based on hospital
   diagnoses
SO AUTISM
LA English
DT Article
DE atypical autism; comorbidity; gastrointestinal diseases
ID INFANTILE-AUTISM; POPULATION; DISORDERS; SPECTRUM; ASSOCIATION;
   SYMPTOMS; COHORT; ASDS
AB The purpose of this study is to compare the prevalence and types of diseases (International Classification of Mental and Behavioural Disorders, 10th Edition codes K20-K93) relating to the gastrointestinal tract in a clinical sample of 89 individuals diagnosed as children with atypical autism/pervasive developmental disorder not otherwise specified with 258 controls from the general population. All participants were screened through the nationwide Danish National Hospital Register. The average observation time was 32.9 years, and mean age at the end of the observation period was 48.5 years. Among the 89 cases with atypical autism, a total of 22 (24.7%) were registered with at least one diagnosis of any disease of the gastrointestinal tract, against 47 of 258 (18.2%) in the comparison group (p = 0.22; odds ratio = 1.5; 95% confidence interval = 0.8-2.6). Without reaching statistical significance, the rate of diseases of the gastrointestinal tract was particularly high (odds ratio = 1.2) in those with intelligence quotient < 70. Overall, people with atypical autism had about the same frequency of gastric, intestinal and hepatic diseases as had controls.
C1 [Mouridsen, Svend Erik] Bispebjerg Hosp, DK-2400 Copenhagen, Denmark.
   [Isager, Torben] Glostrup Univ Hosp, Glostrup, Denmark.
RP Mouridsen, SE (reprint author), Bispebjerg Hosp, DK-2400 Copenhagen, Denmark.
EM Svend.Erik.Mouridsen@regionh.dk
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
   Analytical Software, 2003, STATISTIX 8 US MAN
   Andersen TF, 1999, DAN MED BULL, V46, P263
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Bauman ML, 2010, NEUROTHERAPEUTICS, V7, P320, DOI 10.1016/j.nurt.2010.06.001
   Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C
   Buie T, 2010, PEDIATRICS, V125, pS19, DOI 10.1542/peds.2009-1878D
   Erickson CA, 2005, J AUTISM DEV DISORD, V35, P713, DOI 10.1007/s10803-005-0019-4
   Fombonne E., 2006, PEDIATRICS, V118, P139
   Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237
   Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933
   Maenner MJ, 2012, J AUTISM DEV DISORD, V42, P1520, DOI 10.1007/s10803-011-1379-6
   Mosbech J, 1995, Ugeskr Laeger, V157, P3741
   Mouridsen SE, 2010, CHILD CARE HLTH DEV, V36, P437, DOI 10.1111/j.1365-2214.2009.01021.x
   MOURIDSEN SE, 1993, J AUTISM DEV DISORD, V23, P387, DOI 10.1007/BF01046227
   Nickelsen T N, 2001, Ugeskr Laeger, V164, P33
   Pedersen CB, 2006, DAN MED BULL, V53, P441
   Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124
   Santosh PJ, 2006, EUR CHILD ADOLES PSY, V15, P183, DOI 10.1007/s00787-005-0517-0
   Smith RA, 2009, AUTISM, V13, P343, DOI 10.1177/1362361309106418
   Taylor B, 2002, BRIT MED J, V324, P393, DOI 10.1136/bmj.324.7334.393
   Whitehouse AJO, 2011, DEV MED CHILD NEUROL, V53, P457, DOI 10.1111/j.1469-8749.2011.03915.x
   World Health Organisation, 1992, ICD 10 CLASS MENT BE
   World Health Organization (WHO), 1971, INT CLASS DIS MAN IN
   World Health Organization (WHO), 1978, INT CLASS DIS MENT D
NR 26
TC 2
Z9 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JAN
PY 2013
VL 17
IS 1
BP 55
EP 63
DI 10.1177/1362361312455110
PG 9
WC Psychology, Developmental
SC Psychology
GA 118ZM
UT WOS:000317066100006
PM 22987890
ER

PT J
AU Barbaro, J
   Dissanayake, C
AF Barbaro, Josephine
   Dissanayake, Cheryl
TI Early markers of autism spectrum disorders in infants and toddlers
   prospectively identified in the Social Attention and Communication Study
SO AUTISM
LA English
DT Article
DE autism spectrum disorders; early markers; red flags; prospective;
   infants; toddlers; surveillance; screening
ID TRAITS QUESTIONNAIRE ESAT; FOLLOW-UP; MODIFIED CHECKLIST; HOME
   VIDEOTAPES; 2ND YEAR; CHILDREN; AGE; DIAGNOSIS; LIFE; RECOGNITION
AB The Social Attention and Communication Study involved the successful implementation of developmental surveillance of the early markers of autism spectrum disorders in a community-based setting. The objective in the current study was to determine the most discriminating and predictive markers of autism spectrum disorders used in the Social Attention and Communication Study at 12, 18 and 24 months of age, so that these could be used to identify children with autism spectrum disorders with greater accuracy. The percentage of 'yes/no' responses for each behavioural marker was compared between children with autistic disorder (n = 39), autism spectrum disorder (n = 50) and developmental and/or language delay (n = 20) from 12 to 24 months, with a logistic regression also conducted at 24 months. Across all ages, the recurring key markers of both autistic disorder and autism spectrum disorder were deficits in eye contact and pointing, and from 18 months, deficits in showing became an important marker. In combination, these behaviours, along with pretend play, were found to be the best group of predictors for a best estimate diagnostic classification of autistic disorder/autism spectrum disorder at 24 months. It is argued that the identified markers should be monitored repeatedly during the second year of life by community health-care professionals.
C1 [Barbaro, Josephine; Dissanayake, Cheryl] La Trobe Univ, Bundoora, Vic 3086, Australia.
RP Barbaro, J (reprint author), La Trobe Univ, Olga Tennison Autism Res Ctr, Sch Psychol Sci, Bundoora, Vic 3086, Australia.
EM j.barbaro@latrobe.edu.au
CR ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
   Allison C, 2008, J AUTISM DEV DISORD, V38, P1414, DOI 10.1007/s10803-007-0509-7
   Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007
   Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650
   Barbaro J, 2012, J AUTISM DEV DISORD, DOI [10.1007/s10803-10012-11441-z, DOI 10.1007/S10803-10012-11441-Z]
   Barbaro J, 2010, J DEV BEHAV PEDIATR, V31, P376, DOI 10.1097/DBP.0b013e3181df7f3c
   Barbaro J, 2011, J PEDIATR NURS, V26, P334, DOI 10.1016/j.pedn.2010.04.007
   Barbaro J, 2009, J DEV BEHAV PEDIATR, V30, P447, DOI 10.1097/DBP.0b013e3181ba0f9f
   BARONCOHEN S, 1992, BRIT J PSYCHIAT, V161, P839, DOI 10.1192/bjp.161.6.839
   BARONCOHEN S, 1996, BRIT J PSYCHIAT, V168, P158, DOI DOI 10.1192/BJP.168.2.158
   Bryson SE, 2008, J AUTISM DEV DISORD, V38, P731, DOI 10.1007/s10803-007-0440-y
   Chawarska K, 2009, J CHILD PSYCHOL PSYC, V50, P1235, DOI 10.1111/j.1469-7610.2009.02101.x
   Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x
   Clifford SM, 2008, J AUTISM DEV DISORD, V38, P791, DOI 10.1007/s10803-007-0444-7
   Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
   Dietz C, 2006, J AUTISM DEV DISORD, V36, P713, DOI 10.1007/s10803-006-0114-1
   Howell DC, 2010, STAT METHODS PSYCHOL
   Interactive Autism Network, 2008, 6 IAN
   Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
   Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
   Landa RJ, 2008, NAT CLIN PRACT NEURO, V4, P138, DOI 10.1038/ncpneuro0731
   Le Couteur A, 2008, J AUTISM DEV DISORD, V38, P362, DOI 10.1007/s10803-007-0403-3
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C, 2004, J CHILD PSYCHOL PSYC, V45, P1
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x
   Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185
   Mitchell S, 2006, J DEV BEHAV PEDIATR, V27, pS69, DOI 10.1097/00004703-200604002-00004
   Mullen E, 1995, MULLEN SCALES EARLY
   Nadig AS, 2007, ARCH PEDIAT ADOL MED, V161, P378, DOI 10.1001/archpedi.161.4.378
   Oosterling IJ, 2009, J CHILD PSYCHOL PSYC, V51, P250
   Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239
   Paul R, 2008, AUTISM RES, V1, P97, DOI 10.1002/aur.12
   Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81
   Stone WL, 1999, J CHILD PSYCHOL PSYC, V40, P219, DOI 10.1017/S0021963098003370
   Sullivan M, 2007, J AUTISM DEV DISORD, V37, P37, DOI 10.1007/s10803-006-0335-3
   Swinkels SHN, 2006, J AUTISM DEV DISORD, V36, P723, DOI 10.1007/s10803-006-0115-0
   Turner LM, 2006, AUTISM, V10, P243, DOI 10.1177/1362361306063296
   Watson LR, 2007, J AUTISM DEV DISORD, V37, P49, DOI 10.1007/s10803-006-0334-4
   Werner E, 2000, J AUTISM DEV DISORD, V30, P157, DOI 10.1023/A:1005463707029
   Werner E, 2005, ARCH GEN PSYCHIAT, V62, P889, DOI 10.1001/archpsyc.62.8.889
   Wetherby AM, 2008, AUTISM, V12, P487, DOI 10.1177/1362361308094501
   Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4
   Young RL, 2003, AUTISM, V7, P125, DOI 10.1177/1362361303007002002
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 47
TC 12
Z9 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD JAN
PY 2013
VL 17
IS 1
BP 64
EP 86
DI 10.1177/1362361312442597
PG 23
WC Psychology, Developmental
SC Psychology
GA 118ZM
UT WOS:000317066100007
PM 22735682
ER

PT J
AU Kamp-Becker, I
   Ghahreman, M
   Heinzel-Gutenbrunner, M
   Peters, M
   Remschmidt, H
   Becker, K
AF Kamp-Becker, Inge
   Ghahreman, Mardjan
   Heinzel-Gutenbrunner, Monika
   Peters, Mira
   Remschmidt, Helmut
   Becker, Katja
TI Evaluation of the revised algorithm of Autism Diagnostic Observation
   Schedule (ADOS) in the diagnostic investigation of high-functioning
   children and adolescents with autism spectrum disorders
SO AUTISM
LA English
DT Article
DE ADOS; diagnosis of autism spectrum disorder; Asperger's syndrome;
   high-functioning autism; sensitivity; specificity
ID ADI-R; ASPERGER-SYNDROME; LANGUAGE; VALIDITY; ADULTS; INSTRUMENTS;
   INFORMATION; IMPAIRMENT; ABILITY
AB The Autism Diagnostic Observation Schedule (ADOS) is a semi-structured, standardized assessment designed for use in diagnostic evaluation of individuals with suspected autism spectrum disorder (ASD). The ADOS has been effective in categorizing children who definitely have autism or not, but has lower specificity and sometimes sensitivity for distinguishing children with milder ASDs. Revised ADOS algorithms have been recently developed. The goals of this study were to analyze the predictive validity of different ADOS algorithms for module 3, in particular for high-functioning autism spectrum disorder. The participants were 252 children and adolescents aged between four and 16 years, with a full-scale IQ above 70 (126 with a diagnosis of ASD, 126 with a heterogeneous non-spectrum diagnosis). As a main finding, sensitivity was substantially higher for the newly developed 'revised algorithm', both for autism versus non-spectrum, as well as for the broader ASD versus non-spectrum, using the higher cut-off. The strength of the original algorithm lies in its positive predictive power, while the revised algorithm shows weaknesses in specificity for non-autism ASD. As the ADOS is valid and reliable even for higher functioning ASD, the findings of the present study have been used to make recommendations regarding the best use of ADOS algorithms in a high-functioning sample.
C1 [Kamp-Becker, Inge; Ghahreman, Mardjan; Heinzel-Gutenbrunner, Monika; Peters, Mira; Remschmidt, Helmut; Becker, Katja] Univ Marburg, Dept Child & Adolescent Psychiat, D-35033 Marburg, Germany.
RP Kamp-Becker, I (reprint author), Univ Marburg, Dept Child & Adolescent Psychiat, D-35033 Marburg, Germany.
EM kampbeck@med.uni-marburg.de
CR Bishop DVM, 2002, J CHILD PSYCHOL PSYC, V43, P917, DOI 10.1111/1469-7610.00114
   Bolte S, 2004, Z KINDER JUG-PSYCH, V32, P45, DOI 10.1024/1422-4917.32.1.45
   de Bildt A, 2009, J AUTISM DEV DISORD, V39, P1350, DOI 10.1007/s10803-009-0749-9
   de Bildt A, 2004, J AUTISM DEV DISORD, V34, P129
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
   Hartley SL, 2009, AUTISM, V13, P485, DOI 10.1177/1362361309335717
   Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
   Howlin P, 2005, AUTISM, V9, P533, DOI 10.1177/1362361305057871
   Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899
   Kamp-Becker I, 2010, J AUTISM DEV DISORD, V40, P921, DOI 10.1007/s10803-010-0939-5
   Kamp-Becker I, 2009, J AUTISM DEV DISORD, V39, P557, DOI 10.1007/s10803-008-0656-5
   Le Couteur A, 2008, J AUTISM DEV DISORD, V38, P362, DOI 10.1007/s10803-007-0403-3
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Macintosh KE, 2004, J CHILD PSYCHOL PSYC, V45, P421, DOI 10.1111/j.1469-7610.2004.00234.x
   Mazefsky CA, 2006, AUTISM, V10, P533, DOI 10.1177/136236130606850S
   Mulligan A, 2009, J AUTISM DEV DISORD, V39, P197, DOI 10.1007/s10803-008-0621-3
   Noterdaeme M, 1999, Z KINDER JUG-PSYCH, V27, P251, DOI 10.1024//1422-4917.27.4.251
   Noterdaeme M, 2002, AUTISM, V6, P159, DOI 10.1177/1362361302006002003
   Oosterling I, 2010, J AUTISM DEV DISORD, V40, P689, DOI 10.1007/s10803-009-0915-0
   Overton T, 2008, J AUTISM DEV DISORD, V38, P1166, DOI 10.1007/s10803-007-0488-8
   Petermann F, 2007, HAMBURG WECHSLER INT
   Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
   Ruhl D., 2004, ADOS AUTISM DIAGNOST
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Sanders JL, 2009, J AUTISM DEV DISORD, V39, P1560, DOI 10.1007/s10803-009-0798-0
   Santosh PJ, 2004, EUR CHILD ADOLES PSY, V13, P141, DOI 10.1007/s00787-004-0372-4
   Szatmari P, 2002, J AM ACAD CHILD PSY, V41, P467, DOI 10.1097/00004583-200204000-00020
   Tewes U., 1999, HAMBURG WECHSLER INT
   Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2
   Zhou XH, 2002, STAT METHODS DIAGNOS
NR 34
TC 4
Z9 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JAN
PY 2013
VL 17
IS 1
BP 87
EP 102
DI 10.1177/1362361311408932
PG 16
WC Psychology, Developmental
SC Psychology
GA 118ZM
UT WOS:000317066100008
PM 21610187
ER

PT J
AU Henninger, NA
   Taylor, JL
AF Henninger, Natalie A.
   Taylor, Julie Lounds
TI Outcomes in adults with autism spectrum disorders: a historical
   perspective
SO AUTISM
LA English
DT Article
DE autism spectrum disorders; follow-up; outcome; adulthood
ID QUALITY-OF-LIFE; FOLLOW-UP; ASPERGER-SYNDROME; YOUNG-ADULTS;
   HIGH-SCHOOL; CHILDREN; INDIVIDUALS; POPULATION; TRANSITION; CHILDHOOD
AB In this review, we examine the ways in which researchers have defined successful adult outcomes for individuals with autism spectrum disorders (ASDs) from the first systematic follow-up reports to the present day. The earliest outcome studies used vague and unreliable outcome criteria, and institutionalization was a common marker of poor outcomes. In the past decade, researchers have begun to standardize the measurement of adult outcomes with specific criteria based on friendships, employment, and living arrangements. Although nearly all of these studies have agreed that the majority of adults with ASD have poor outcomes, evolving concepts of what it means to be an adult could have an impact on outcomes measured. For example, some researchers have suggested that taking into account the person-environment fit could reveal a more optimistic picture of outcomes for these adults. Suggestions for future research are discussed.
C1 [Henninger, Natalie A.] Vanderbilt Univ, Nashville, TN USA.
   [Henninger, Natalie A.; Taylor, Julie Lounds] Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
   [Taylor, Julie Lounds] Vanderbilt Univ, Vanderbilt Kennedy Ctr, Sch Med, Nashville, TN USA.
   [Taylor, Julie Lounds] Monroe Carell Jr Childrens Hosp Vanderbilt, Nashville, TN USA.
RP Taylor, JL (reprint author), Vanderbilt Kennedy Ctr, PMB 40-230 Appleton Pl, Nashville, TN 37203 USA.
EM Julie.l.taylor@vanderbilt.edu
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Arnett JJ, 2000, AM PSYCHOL, V55, P469, DOI 10.1037//0003-066X.55.5.469
   Arnett JJ, 2001, J ADULT DEV, V8, P133, DOI 10.1023/A:1026450103225
   BallabanGil K, 1996, PEDIATR NEUROL, V15, P217, DOI 10.1016/S0887-8994(96)00219-6
   Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5
   Billstedt E, 2011, AUTISM, V15, P7, DOI 10.1177/1362361309346066
   Cederlund M, 2008, J AUTISM DEV DISORD, V38, P72, DOI 10.1007/s10803-007-0364-6
   Eaves LC, 2008, J AUTISM DEV DISORD, V38, P739, DOI 10.1007/s10803-007-0441-x
   Engstrom I, 2003, AUTISM, V7, P99, DOI 10.1177/1362361303007001008
   Esbensen AJ, 2010, AJIDD-AM J INTELLECT, V115, P277, DOI 10.1352/1944-7558-115.4.277
   Farley MA, 2009, AUTISM RES, V2, P109, DOI 10.1002/aur.69
   Furstenberg F. F., 2005, FRONTIER ADULTHOOD T, P3
   Fussell E., 2005, FRONTIER ADULTHOOD T, P29
   GILLBERG C, 1987, J AUTISM DEV DISORD, V17, P273, DOI 10.1007/BF01495061
   Gillespie-Lynch K, 2011, J AUTISM DEV DISORD, V42, P161
   HALPERN AS, 1993, EXCEPT CHILDREN, V59, P486
   Howlin P., 2005, HDB AUTISM PERVASIVE, V1, P201
   Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806
   Howlin P, CANADIAN J PSYCHIAT
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Kanner L, 1943, NERV CHILD, V2, P217
   KANNER L, 1971, J AUTISM CHILD SCHIZ, V1, P119, DOI 10.1007/BF01537953
   KOBAYASHI R, 1992, J AUTISM DEV DISORD, V22, P395, DOI 10.1007/BF01048242
   Larsen FW, 1997, EUR CHILD ADOLES PSY, V6, P181
   Lotter V., 1978, AUTISM REAPPRAISAL C, P475
   LOTTER V, 1974, J AUTISM CHILD SCHIZ, V4, P11, DOI 10.1007/BF02104997
   Newman L., 2011, POSTHIGH SCH OUTCOME
   Ruble L. A., 1996, FOCUS AUTISM OTHER D, V11, P3
   RUTTER M, 1967, BRIT J PSYCHIAT, V113, P1183, DOI 10.1192/bjp.113.504.1183
   Shattuck P, CANADIAN J IN PRESS
   Shattuck PT, 2011, ARCH PEDIAT ADOL MED, V165, P141, DOI 10.1001/archpediatrics.2010.279
   Taylor JL, 2010, J AUTISM DEV DISORD, V40, P1431, DOI 10.1007/s10803-010-1005-z
   Taylor JL, 2009, INT REV RES MENT RET, V38, P1, DOI 10.1016/S0074-7750(08)38001-X
   Will M., 1984, OSERS PROGRAMMING TR
NR 34
TC 16
Z9 17
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JAN
PY 2013
VL 17
IS 1
BP 103
EP 116
DI 10.1177/1362361312441266
PG 14
WC Psychology, Developmental
SC Psychology
GA 118ZM
UT WOS:000317066100009
PM 22914775
ER

PT J
AU Falter, CM
AF Falter, Christine M.
TI Impaired and superior mirror symmetry perception in autism
SO AUTISM
LA English
DT Letter
ID INDIVIDUALS
C1 [Falter, Christine M.] Univ Groningen, Groningen, Netherlands.
RP Falter, CM (reprint author), Univ Groningen, Dept Neuropsychol, Groningen, Netherlands.
EM C.M.Falter@rug.nl
CR Falter CM, 2010, AUTISM RES, V3, P128, DOI 10.1002/aur.134
   Falter CM, 2011, AUTISM
   Perreault A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019519
   Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x
   Ropar D, 1999, J CHILD PSYCHOL PSYC, V40, P1283, DOI 10.1017/S0021963099004667
   SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x
NR 6
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD JAN
PY 2013
VL 17
IS 1
BP 117
EP 118
DI 10.1177/1362361312438618
PG 2
WC Psychology, Developmental
SC Psychology
GA 118ZM
UT WOS:000317066100010
PM 23045219
ER

PT J
AU Plenty, S
   Heurlin, D
   Arlinde, C
   Bejerot, S
AF Plenty, Stephanie
   Heurlin, Dag
   Arlinde, Christina
   Bejerot, Susanne
TI Applying an ESSENCE Framework to Understanding Adult Autism Spectrum
   Disorder and ADHD: Retrospective Parent Reports of Childhood Problems
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
   DISORDER; DEVELOPMENTAL COORDINATION DISORDER; HIGH-FUNCTIONING AUTISM;
   AGE-DEPENDENT DECLINE; FTF 5; ASPERGER-SYNDROME; DIAGNOSTIC INTERVIEW;
   LANGUAGE IMPAIRMENT; 15 QUESTIONNAIRE
AB Diagnoses of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are increasingly being made in adulthood. However, assessments can fail to address the diverse range of problems that patients have experienced. The current study applied an early symptomatic syndromes eliciting neurodevelopmental clinical examinations (ESSENCE) framework to explore retrospectively reported childhood developmental and behavioral problems. It examined if adult ASD and ADHD patients would show problems outside those reflected in the respective diagnostic criteria, and also if these patient groups would show more extensive childhood problems than other psychiatric patients. Parents of adults with ADHD (n = 130), ASD (n = 57), coexisting ADHD and ASD (n = 38), and other psychiatric disorders (n = 56) reported on a range of childhood problems. Descriptions of the ADHD, ASD, and ADHD+ASD groups reflected greater impairment than descriptions for patients with other psychiatric disorders in most problem areas. Although differences were observed between ADHD and ASD patients in the core diagnostic areas, these syndromes also shared a number of childhood difficulties. The ESSENCE approach can assist in understanding the symptom history of adult ADHD and ASD patients and can be helpful to distinguish their childhood experiences from other psychiatric patients' experiences.
C1 [Plenty, Stephanie; Heurlin, Dag; Arlinde, Christina; Bejerot, Susanne] Karolinska Inst, Dept Clin Neurosci, S-17177 Stockholm, Sweden.
   [Bejerot, Susanne] St Goran Hosp, VUB KOGNUS, Northen Stockholm Psychiat, S-11281 Stockholm, Sweden.
RP Bejerot, S (reprint author), Karolinska Inst, Dept Clin Neurosci, S-17177 Stockholm, Sweden.
EM susanne.bejerot@gmail.com
FU Stockholm County Council (ALF); Karolinska Institutet, Stockholm,
   Sweden; Swedish Research Council [523-2011-3646]
FX The financial support was provided through the regional agreement for
   support for research between Stockholm County Council (ALF) and
   Karolinska Institutet, Stockholm, Sweden, and S. Bejerot received Grants
   from the Swedish Research Council (no. 523-2011-3646).
CR Allman MJ, 2012, BRAIN, V135, P656, DOI 10.1093/brain/awr210
   Alloway TP, 2009, J LEARN DISABIL-US, V42, P372, DOI 10.1177/0022219409335214
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Banaschewski T, 2005, DEVELOPMENTAL SCI, V8, P132, DOI 10.1111/j.1467-7687.2005.00400.x
   Barkley R. A., 2012, EXECUTIVE FUNCTIONS
   Biederman J, 2000, AM J PSYCHIAT, V157, P816, DOI 10.1176/appi.ajp.157.5.816
   Bohlin G, 2004, EUR CHILD ADOLES PSY, V13, P14, DOI 10.1007/s00787-004-3003-1
   Bruce B, 2006, EUR CHILD ADOLES PSY, V15, P52, DOI 10.1007/s00787-006-0508-9
   Buhler E, 2011, J AUTISM DEV DISORD, V41, P1718, DOI 10.1007/s10803-011-1205-1
   Bussing R, 2010, J AM ACAD CHILD PSY, V49, P595, DOI 10.1016/j.jaac.2010.03.006
   Dewey D, 2007, J INT NEUROPSYCH SOC, V13, P246, DOI 10.1017/S1355617707070270
   Ehlers S, 1999, J AUTISM DEV DISORD, V29, P129, DOI 10.1023/A:1023040610384
   Faraone SV, 2006, PSYCHOL MED, V36, P159, DOI 10.1017/S003329170500471X
   Fayyad J, 2007, BRIT J PSYCHIAT, V190, P402, DOI 10.1192/bjp.bp.106.034389
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
   Gargaro BA, 2011, NEUROSCI BIOBEHAV R, V35, P1081, DOI 10.1016/j.neubiorev.2010.11.002
   GHAZIUDDIN M, 1994, J INTELL DISABIL RES, V38, P519
   Gillberg C, 2001, AUTISM, V5, P57, DOI 10.1177/1362361301005001006
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Gillberg C, 2000, ACTA PSYCHIAT SCAND, V102, P321, DOI 10.1034/j.1600-0447.2000.102005321.x
   Greven CU, 2012, J CHILD PSYCHOL PSYC, V53, P234, DOI 10.1111/j.1469-7610.2011.02445.x
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
   Kadesjo B, 2004, EUR CHILD ADOLES PSY, V13, P3, DOI 10.1007/s00787-004-3002-2
   Kaplan BJ, 1998, J CLIN EXP NEUROPSYC, V20, P518, DOI 10.1076/jcen.20.4.518.1477
   Karam RG, 2009, J PSYCHIATR RES, V43, P697, DOI 10.1016/j.jpsychires.2008.10.001
   Kooij SJJ, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-67
   Kopp S, 2010, RES DEV DISABIL, V31, P350, DOI 10.1016/j.ridd.2009.09.017
   Korkman M, 2004, EUR CHILD ADOLES PSY, V13, P31, DOI 10.1007/s00787-004-3005-z
   Leyfer OT, 2008, AUTISM RES, V1, P284, DOI 10.1002/aur.43
   Lindblad I, 2011, RES DEV DISABIL, V32, P2805, DOI 10.1016/j.ridd.2011.05.026
   Mandell DS, 2005, PSYCHIAT SERV, V56, P56, DOI 10.1176/appi.ps.56.1.56
   Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
   Mattila ML, 2010, J AUTISM DEV DISORD, V40, P1080, DOI 10.1007/s10803-010-0958-2
   Meaux Julie B, 2003, J Pediatr Health Care, V17, P64, DOI 10.1016/S0891-5245(02)88326-2
   Nyden A, 2010, RES DEV DISABIL, V31, P1659, DOI 10.1016/j.ridd.2010.04.010
   Park S, 2011, PSYCHIAT RES, V186, P378, DOI 10.1016/j.psychres.2010.07.047
   Reimherr FW, 2005, BIOL PSYCHIAT, V58, P125, DOI 10.1016/j.biopsych.2005.04.040
   Reynolds AM, 2011, PEDIATR CLIN N AM, V58, P685, DOI 10.1016/j.pcl.2011.03.009
   Ryden E, 2008, CLIN NEUROPSYCHIATRY, V5, P13
   Ryden E, 2009, ACTA PSYCHIAT SCAND, V120, P239, DOI 10.1111/j.1600-0447.2009.01399.x
   Semrud-Clikeman M, 2010, J AUTISM DEV DISORD, V40, P1017, DOI 10.1007/s10803-010-0951-9
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Sinzig Judith, 2008, Child Adolesc Psychiatry Ment Health, V2, P4, DOI 10.1186/1753-2000-2-4
   Spruyt K, 2011, EXPERT REV NEUROTHER, V11, P565, DOI [10.1586/ern.11.7, 10.1586/ERN.11.7]
   Stahlberg O, 2004, J NEURAL TRANSM, V111, P891, DOI 10.1007/s00702-004-0115-1
   Startup M, 2002, BRIT J CLIN PSYCHOL, V41, P417, DOI 10.1348/014466502760387533
   StatSoft, 2005, STATISTICA
   Taurines Regina, 2012, Atten Defic Hyperact Disord, V4, P115, DOI 10.1007/s12402-012-0086-2
   Trillingsgaard A, 2004, EUR CHILD ADOLES PSY, V13, P39, DOI 10.1007/s00787-004-3006-y
   WARD MF, 1993, AM J PSYCHIAT, V150, P885
NR 52
TC 0
Z9 0
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 469594
DI 10.1155/2013/469594
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 120XC
UT WOS:000317205500001
ER

PT J
AU Ellison, JW
   Rosenfeld, JA
   Shaffer, LG
AF Ellison, Jay W.
   Rosenfeld, Jill A.
   Shaffer, Lisa G.
BE Caskey, CT
TI Genetic Basis of Intellectual Disability
SO ANNUAL REVIEW OF MEDICINE, VOL 64
SE Annual Review of Medicine
LA English
DT Review; Book Chapter
DE microarray analysis; chromosome disorder; next-generation sequencing;
   neurodevelopmental phenotypes
ID FRAGILE-X-SYNDROME; 17Q21.31 MICRODELETION SYNDROME; LINKED
   MENTAL-RETARDATION; AUTISM SPECTRUM DISORDERS; COPY NUMBER VARIATION;
   DEVELOPMENTAL DELAY; KANSL1 CAUSE; CGG REPEAT; MUTATIONS; SCHIZOPHRENIA
AB In the past decade, we have witnessed a flood of reports about mutations that cause or contribute to intellectual disability (ID). This rapid progress has been driven in large part by the implementation of chromosomal microarray analysis and next-generation sequencing methods. The findings have revealed extensive genetic heterogeneity for ID, as well as examples of a common genetic etiology for ID and other neurobehavioral/psychiatric phenotypes. Clinical diagnostic application of these new findings is already well under way, despite incomplete understanding of non-Mendelian transmission patterns that are sometimes observed.
C1 [Ellison, Jay W.; Rosenfeld, Jill A.; Shaffer, Lisa G.] PerkinElmer Inc, Signature Genom Labs, Spokane, WA 99207 USA.
RP Ellison, JW (reprint author), PerkinElmer Inc, Signature Genom Labs, Spokane, WA 99207 USA.
EM jay.ellison@perkinelmer.com; jill.mokry@perkinelmer.com;
   lisagailshaffer@gmail.com
CR American Association on Intellectual and Developmental Disabilities (AAIDD), 2010, AAIDD ANN M PROV RI
   Badano JL, 2002, NAT REV GENET, V3, P779, DOI 10.1038/nrg910
   Ballif BC, 2012, HUM GENET, V131, P145, DOI 10.1007/s00439-011-1073-y
   Bryson SE, 2008, CAN J PSYCHIAT, V53, P449
   Centers for Disease Control and Prevention, 2004, MMWR-MORBID MORTAL W, V53, P57
   Christodoulou J, 2001, GENEREVIEWS, P1993
   Coffee B, 2009, AM J HUM GENET, V85, P503, DOI 10.1016/j.ajhg.2009.09.007
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   FU YH, 1991, CELL, V67, P1047, DOI 10.1016/0092-8674(91)90283-5
   Girirajan S, 2010, NAT GENET, V42, P203, DOI 10.1038/ng.534
   Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80
   Hamdan FF, 2011, AM J HUM GENET, V88, P306, DOI 10.1016/j.ajhg.2011.02.001
   Hochstenbach R, 2009, EUR J MED GENET, V52, P161, DOI 10.1016/j.ejmg.2009.03.015
   Hu H, 2011, AM J HUM GENET, V89, P407, DOI 10.1016/j.ajhg.2011.08.008
   Huang K, 2011, Clin Genet, V79, P427, DOI 10.1111/j.1399-0004.2011.01630.x
   Kaminsky EB, 2011, GENET MED, V13, P777, DOI 10.1097/GIM.0b013e31822c79f9
   Kaufman L, 2010, J NEURODEV DISORD, V2, P182, DOI 10.1007/s11689-010-9055-2
   Koolen DA, 2012, NAT GENET, V44, P639, DOI 10.1038/ng.2262
   Kuss AW, 2011, HUM GENET, V129, P141, DOI 10.1007/s00439-010-0907-3
   Leonard H, 2002, MENT RETARD DEV D R, V8, P117, DOI 10.1002/mrdd.10031
   Lubs HA, 2012, AM J HUM GENET, V90, P579, DOI 10.1016/j.ajhg.2012.02.018
   Lugtenberg D, 2007, GENET MED, V9, P560, DOI 10.1097/GIM.0b013e318149e647
   Lupski JR, 2010, NAT GENET, V42, P1036, DOI 10.1038/ng1210-1036
   Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
   Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
   Mefford HC, 2012, NEW ENGL J MED, V366, P733, DOI 10.1056/NEJMra1114194
   Melom JE, 2011, CURR OPIN GENET DEV, V21, P256, DOI 10.1016/j.gde.2011.01.002
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   Mitchell KJ, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-1-237
   Mitchell KJ, 2007, PLOS BIOL, V5, P690, DOI 10.1371/journal.pbio.0050113
   Morrow EM, 2010, J AM ACAD CHILD PSY, V49, P1091, DOI 10.1016/j.jaac.2010.08.009
   Najmabadi H, 2011, NATURE, V478, P57, DOI 10.1038/nature10423
   Need AC, 2012, J MED GENET, V49, P353, DOI 10.1136/jmedgenet-2012-100819
   Penrose LS, 1938, CLIN GENETIC STUDY 1
   PIERETTI M, 1991, CELL, V66, P817, DOI 10.1016/0092-8674(91)90125-I
   Rauch A, 2006, AM J MED GENET A, V140A, P2063, DOI 10.1002/ajmg.a.31416
   Robinson PN, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-12-144
   Ropers HH, 2010, ANNU REV GENOM HUM G, V11, P161, DOI 10.1146/annurev-genom-082509-141640
   Ropers HH, 2005, NAT REV GENET, V6, P46, DOI 10.1038/nrg1501
   Salvador-Carulla L, 2008, PSYCHOPATHOLOGY, V41, P10, DOI 10.1159/000109950
   Schaaf CP, 2011, HUM MOL GENET, V20, P3366, DOI 10.1093/hmg/ddr243
   Sebat J, 2009, TRENDS GENET, V25, P528, DOI 10.1016/j.tig.2009.10.004
   Talkowski ME, 2011, AM J HUM GENET, V89, P551, DOI 10.1016/j.ajhg.2011.09.011
   Tarpey PS, 2009, NAT GENET, V41, P535, DOI 10.1038/ng.367
   Thornton GK, 2009, TRENDS GENET, V25, P501, DOI 10.1016/j.tig.2009.09.011
   VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H
   Vissers LELM, 2010, J MED GENET, V47, P289, DOI 10.1136/jmg.2009.072942
   Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
   Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174
   Weedon MN, 2011, AM J HUM GENET, V89, P308, DOI 10.1016/j.ajhg.2011.07.002
   Willemsen MH, 2012, J MED GENET, V49, P179, DOI 10.1136/jmedgenet-2011-100542
   World Health Organization: Regional Office for Europe, 2010, DEF INT DIS
   Zahir F, 2007, CLIN GENET, V72, P271, DOI 10.1111/j.1399-0004.2007.00847.x
   Zoghbi HY, 2010, NEURON, V68, P165, DOI 10.1016/j.neuron.2010.10.015
   Zollino M, 2012, NAT GENET, V44, P636, DOI 10.1038/ng.2257
NR 57
TC 17
Z9 17
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0066-4219
BN 978-0-8243-0564-2
J9 ANNU REV MED
JI Annu. Rev. Med.
PY 2013
VL 64
BP 441
EP 450
DI 10.1146/annurev-med-042711-140053
PG 10
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA BEF31
UT WOS:000316384400031
PM 23020879
ER

PT J
AU Kanakam, N
   Treasure, J
AF Kanakam, Natalie
   Treasure, Janet
TI A review of cognitive neuropsychiatry in the taxonomy of eating
   disorders: State, trait, or genetic?
SO COGNITIVE NEUROPSYCHIATRY
LA English
DT Article
DE Eating disorders; Emotion; Endophenotype; Genetic; Neuropsychology; Set
   shifting
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
   DISORDER; AUTISM SPECTRUM DISORDERS; ANOREXIA-NERVOSA PATIENTS;
   IOWA-GAMBLING-TASK; COMPULSIVE PERSONALITY-TRAITS; SEROTONIN TRANSPORTER
   GENE; SET-SHIFTING ABILITY; BULIMIA-NERVOSA; DECISION-MAKING
AB A greater understanding of neuropsychological traits in eating disorders may help to construct a more biologically based taxonomy. The aim of this paper is to review the current evidence base of neuropsychological traits in people with eating disorders. Evidence of difficulties in set shifting, weak central coherence, emotional processing difficulties, and altered reward sensitivity is presented for people both in the acute and recovered phase of the illness. These traits are also seen in first degree relatives. At present there is limited research linking these neuropsychological traits with genetic and neuroanatomical measures. In addition to improving the taxonomy of eating disorders, neuropsychological traits may be of value in producing targeted treatments.
C1 [Kanakam, Natalie; Treasure, Janet] Kings Coll London, Inst Psychiat, Sect Eating Disorders, London SE1 9RT, England.
RP Kanakam, N (reprint author), Kings Coll London, Dept Psychol Med, Guys Hosp, 5th Floor Bermondsey Wing, London SE1 9RT, England.
EM Natalie.kanakam@kcl.ac.uk
CR Abbate-Daga G, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-162
   Adolphs Ralph, 2002, Behav Cogn Neurosci Rev, V1, P21, DOI 10.1177/1534582302001001003
   Aldao A, 2010, CLIN PSYCHOL REV, V30, P217, DOI 10.1016/j.cpr.2009.11.004
   Alvarado-Sanches A., 2009, SPAN J PSYCHOL, V12, P677
   Anderluh M, 2009, PSYCHOL MED, V39, P105, DOI 10.1017/S0033291708003292
   Anderluh MB, 2003, AM J PSYCHIAT, V160, P242, DOI 10.1176/appi.ajp.160.2.242
   Anokhin AP, 2010, BEHAV GENET, V40, P178, DOI 10.1007/s10519-010-9337-1
   Arts B, 2008, PSYCHOL MED, V38, P771, DOI 10.1017/S0033291707001675
   Ashwin C, 2006, PSYCHOL MED, V36, P835, DOI 10.1017/S0033291706007203
   Ashworth F, 2011, PSYCHOL MED, V41, P2375, DOI 10.1017/S0033291711000626
   Avena NM, 2005, PHYSIOL BEHAV, V84, P359, DOI 10.1016/j.physbeh.2004.12.016
   Avena NM, 2003, NEUROSCIENCE, V122, P17, DOI 10.1016/S0306-4522(03)00502-5
   Barnett JH, 2008, BIOL PSYCHIAT, V64, P137, DOI 10.1016/j.biopsych.2008.01.005
   Baron-Cohen S, 2006, BRAIN COGNITION, V61, P122, DOI 10.1016/j.bandc.2005.12.011
   BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548
   Barrantes-Vidal N, 2007, SCHIZOPHR RES, V95, P70, DOI 10.1016/j.schres.2007.06.020
   BASSECHES HI, 1984, PSYCHOTHER PSYCHOSOM, V41, P33
   Beaver JD, 2008, J NEUROSCI, V28, P2719, DOI 10.1523/JNEUROSCI.0033-08.2008
   Bechara A, 2004, NAT NEUROSCI, V7, P102, DOI 10.1038/nn0204-102
   BECHARA A, 1994, COGNITION, V50, P7, DOI 10.1016/0010-0277(94)90018-3
   Beevers CG, 2009, J ABNORM PSYCHOL, V118, P670, DOI 10.1037/a0016198
   Bernstein JH, 1996, DEV SCORING SYSTEM R
   Berridge KC, 2007, PSYCHOPHARMACOLOGY, V191, P391, DOI 10.1007/s00213-006-0578-x
   Bidwell LC, 2007, BIOL PSYCHIAT, V62, P991, DOI 10.1016/j.biopsych.2007.04.003
   Bijttebier P, 2009, CLIN PSYCHOL REV, V29, P421, DOI 10.1016/j.cpr.2009.04.002
   Blasi G, 2009, J NEUROSCI, V29, P14812, DOI 10.1523/JNEUROSCI.3609-09.2009
   Boeka AG, 2006, J INT NEUROPSYCH SOC, V12, P741, DOI 10.1017/S1355617706060887
   Boggiano N. M., 2005, BEHAV NEUROSCI, V119, P1207
   Boggiano N. M., 2007, INT J OBESITY, V31, P1357
   Boisseau CL, 2009, J NERV MENT DIS, V197, P251, DOI 10.1097/NMD.0b013e31819d96c0
   Bolte S, 2006, J CHILD PSYCHOL PSYC, V47, P639, DOI 10.1111/j.1469-7610.2006.01603.x
   Booth R., 2006, THESIS KINGS COLL U
   Bora E., 2008, J AFFECT DISORDERS, V113, P1
   Bosia M., 2009, PROG NEUROPSYCHOPHAR, V34, P81
   Brand M, 2007, NEUROPSYCHOLOGY, V21, P742, DOI 10.1037/0844-4105.21.6.742
   Breton Florence, 2011, Neuropsychologia, V49, P203, DOI 10.1016/j.neuropsychologia.2010.11.019
   Brock J, 2002, DEV PSYCHOPATHOL, V14, P209
   Brogan A, 2010, J INT NEUROPSYCH SOC, V16, P711, DOI 10.1017/S1355617710000354
   Bucci P., 2010, EUROPEAN PSYCHIAT, V25, P1005
   Bulik CM, 2003, AM J HUM GENET, V72, P200, DOI 10.1086/345801
   Burgess PW, 1997, HAYLING BRIXTON TEST
   Calder AJ, 2001, NAT REV NEUROSCI, V2, P352, DOI 10.1038/35072584
   Campbell-Sills L, 2006, BEHAV RES THER, V44, P1251, DOI 10.1016/j.brat.2005.10.001
   Cardi V, 2013, WORLD J BIOL PSYCHIA, V14, P622, DOI 10.3109/15622975.2012.665479
   Carrasco X, 2006, AM J MED GENET B, V141B, P51, DOI 10.1002/ajmg.b.30259
   Cavedini P., 2004, PSYCHIAT RES, V127, P1259
   Cavedini P, 2010, BIOL PSYCHIAT, V67, P1178, DOI 10.1016/j.biopsych.2010.02.012
   Cavedini P, 2006, PSYCHIAT RES, V145, P179, DOI 10.1016/j.psychres.2004.12.014
   Claes L, 2010, PERS INDIV DIFFER, V48, P166, DOI 10.1016/j.paid.2009.09.016
   Claes L, 2001, Eat Behav, V2, P263, DOI 10.1016/S1471-0153(01)00033-2
   Congdon E, 2008, J PERS, V76, P1447, DOI 10.1111/j.1467-6494.2008.00528.x
   Corwin RL, 2006, APPETITE, V46, P11, DOI 10.1016/j.appet.2004.09.002
   Corwin RL, 2005, PHYSIOL BEHAV, V86, P5, DOI 10.1016/j.physbeh.2005.06.021
   Craig B. H., 2006, J CLIN PSYCHIAT, V67, P351
   Crane AM, 2007, INT J EAT DISORDER, V40, P581, DOI 10.1002/eat.20419
   Davis C, 2010, APPETITE, V54, P208, DOI 10.1016/j.appet.2009.11.002
   De Achaval D., 2009, NEUROPSYCHOLOGIA, V48, P1209
   de Jonge MV, 2006, J AUTISM DEV DISORD, V36, P677, DOI 10.1007/s10803-006-0113-2
   Doyle AE, 2008, AM J MED GENET B, V147B, P1399, DOI 10.1002/ajmg.b.30868
   Doyle AE, 2009, PSYCHOL MED, V39, P1253, DOI 10.1017/S0033291708004832
   DREWNOWSKI A, 1988, Appetite, V10, P119, DOI 10.1016/0195-6663(88)90063-3
   Eddy KT, 2008, AM J PSYCHIAT, V165, P245, DOI 10.1176/appi.ajp.2007.07060951
   Eisen SA, 1998, ADDICTION, V93, P1375
   EKMAN P, 1976, ENVIRON PSYCH NONVER, V1, P56, DOI 10.1007/BF01115465
   ESLINGER PJ, 1993, NEUROPSYCHOLOGIA, V31, P17, DOI 10.1016/0028-3932(93)90077-D
   Evenden JL, 1999, PSYCHOPHARMACOLOGY, V146, P348, DOI 10.1007/PL00005481
   Faraone SV, 2001, AM J PSYCHIAT, V158, P1052, DOI 10.1176/appi.ajp.158.7.1052
   Fassino S, 2002, INT J EAT DISORDER, V31, P274, DOI 10.1002/eat.10028
   Fernandez-Aranda F, 2008, PSYCHIAT RES, V157, P147, DOI 10.1016/j.psychres.2007.02.011
   Fichter MM, 2006, INT J EAT DISORDER, V39, P87, DOI 10.1002/eat.20215
   Figee D., 2010, BIOL PSYCHIAT, V69, P867, DOI [10.1016/j.biopsych.2010.12.003, DOI 10.1016/J.BIOPSYCH.2010.12.003]
   First MB, 2004, AM J PSYCHIAT, V161, P946, DOI 10.1176/appi.ajp.161.6.946
   Fischer S, 2008, CLIN PSYCHOL REV, V28, P1413, DOI 10.1016/j.cpr.2008.09.001
   Fischer S, 2003, INT J EAT DISORDER, V33, P406, DOI 10.1002/eat.10165
   Fisher PM, 2009, CEREB CORTEX, V19, P2499, DOI 10.1093/cercor/bhp022
   Fox E, 2009, P R SOC B, V276, P1747, DOI 10.1098/rspb.2008.1788
   Frantom LV, 2008, BIPOLAR DISORD, V10, P387, DOI 10.1111/j.1399-5618.2007.00529.x
   Frith C, 2004, LANCET NEUROL, V3, P577, DOI 10.1016/S1474-4422(04)00875-0
   Gadas M., 2009, POSTEPY PSYCHIAT NEU, V18, P59
   Garavan H, 2002, NEUROIMAGE, V17, P1820, DOI 10.1006/nimg.2002.1326
   Gillberg IC, 1996, COMPR PSYCHIAT, V37, P23, DOI 10.1016/S0010-440X(96)90046-2
   Glahn DC, 2012, BIOL PSYCHIAT, V71, P6, DOI 10.1016/j.biopsych.2011.08.022
   Godart N, 2006, AM J PSYCHIAT, V163, P326, DOI 10.1176/appi.ajp.163.2.326
   Godart NT, 2000, EUR PSYCHIAT, V15, P38, DOI 10.1016/S0924-9338(00)00212-1
   Godart NT, 2007, J AFFECT DISORDERS, V97, P37, DOI 10.1016/j.jad.2006.06.023
   Goddard E., 2012, THESIS KINGS COLL LO
   Goldner EM, 1999, PSYCHIAT RES, V85, P151, DOI 10.1016/S0165-1781(98)00145-0
   Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
   Gourovitch ML, 1999, BIOL PSYCHIAT, V45, P639, DOI 10.1016/S0006-3223(98)00148-6
   Gross JJ, 2003, J PERS SOC PSYCHOL, V85, P348, DOI 10.1037/0022-3514.85.2.348
   Gross JJ, 2002, PSYCHOPHYSIOLOGY, V39, P281, DOI 10.1017/S0048577201393198
   Gross JJ, 1998, J PERS SOC PSYCHOL, V74, P224, DOI 10.1037//0022-3514.74.1.224
   Happe F, 2001, J CHILD PSYCHOL PSYC, V42, P299, DOI 10.1111/1469-7610.00723
   Happe FGE, 2008, Q J EXP PSYCHOL, V61, P50, DOI 10.1080/17470210701508731
   Hariri AR, 2000, NEUROREPORT, V11, P43, DOI 10.1097/00001756-200001170-00009
   Hariri AR, 2002, SCIENCE, V297, P400, DOI 10.1126/science.1071829
   Harrison A, 2009, CLIN PSYCHOL PSYCHOT, V16, P348, DOI 10.1002/cpp.628
   Harrison A., 2010, THESIS KINGS COLL LO
   Harrison A, 2010, PSYCHOL MED, V40, P1887, DOI 10.1017/S0033291710000036
   Harrison A., 2012, EXPT MEASUREME UNPUB
   Harrison A, 2011, PSYCHIAT RES, V188, P396, DOI 10.1016/j.psychres.2011.04.022
   Harrison A, 2011, WORLD J BIOL PSYCHIA, V12, P462, DOI 10.3109/15622975.2010.551666
   Harrison A, 2010, BIOL PSYCHIAT, V68, P755, DOI 10.1016/j.biopsych.2010.04.037
   Harrison A, 2010, PSYCHIAT RES, V177, P1, DOI 10.1016/j.psychres.2009.06.010
   Hartmann A, 2010, INT J EAT DISORDER, V43, P619, DOI 10.1002/eat.20747
   Hassel S, 2009, J AFFECT DISORDERS, V118, P19, DOI 10.1016/j.jad.2009.01.021
   Heaton RK, 1993, WISCONSIN CARD SORTI
   Hill SY, 2007, ALCOHOL CLIN EXP RES, V31, P2028, DOI 10.1111/j.1530-0277.2007.00535.x
   Holliday J, 2005, AM J PSYCHIAT, V162, P2269, DOI 10.1176/appi.ajp.162.12.2269
   Hudson JI, 2007, BIOL PSYCHIAT, V61, P348, DOI 10.1016/j.biopsych.2006.03.040
   Jacobi C, 2004, PSYCHOL BULL, V130, P19, DOI 10.1037/0033-2909.130.1.19
   Jappe LM, 2011, INT J EAT DISORDER, V44, P317, DOI 10.1002/eat.20815
   JONES BP, 1991, J CLIN EXP NEUROPSYC, V13, P711, DOI 10.1080/01688639108401085
   Juselius S, 2009, ARCH CLIN NEUROPSYCH, V24, P599, DOI 10.1093/arclin/acp047
   Karwautz AFK, 2011, MOL PSYCHIATR, V16, P590, DOI 10.1038/mp.2010.125
   Kaye WH, 2004, AM J PSYCHIAT, V161, P2215, DOI 10.1176/appi.ajp.161.12.2215
   Kim YR, 2010, PSYCHIAT INVEST, V7, P298, DOI 10.4306/pi.2010.7.4.298
   Klemm S, 2006, EUR CHILD ADOLES PSY, V15, P400, DOI 10.1007/s00787-006-0547-2
   Klimes-Dougan B, 2006, BIOL PSYCHIAT, V60, P957, DOI 10.1016/j.biopsych.2006.03.031
   Koba T., 2002, SEISHIN IGAKU, V44, P681
   Kohari R., NEUROPSYCHOLOG UNPUB
   Konstantakopoulos G, 2011, PSYCHOL MED, V41, P1951, DOI 10.1017/S0033291710002539
   Krug I, 2009, PSYCHIAT CLIN NEUROS, V63, P82, DOI 10.1111/j.1440-1819.2008.01908.x
   Kuhnpast N., 2009, SOC P CLIN NEUROPHYS, V120, pe9
   Kulkarni S, 2010, BIPOLAR DISORD, V12, P647, DOI 10.1111/j.1399-5618.2010.00857.x
   Lee KJ, 2008, ACTA PSYCHIAT SCAND, V118, P200, DOI 10.1111/j.1600-0447.2008.01223.x
   Li DW, 2006, HUM MOL GENET, V15, P2276, DOI 10.1093/hmg/ddl152
   Liao PC, 2009, J CLIN EXP NEUROPSYC, V31, P455, DOI 10.1080/13803390802251378
   Lien YJ, 2010, GENES BRAIN BEHAV, V9, P695, DOI 10.1111/j.1601-183X.2010.00599.x
   Lopez C, 2008, PSYCHOL MED, V38, P1393, DOI 10.1017/S0033291708003486
   Lopez C, 2010, ANN GEN PSYCHIATR, V9, P1
   Lopez C, 2008, INT J EAT DISORDER, V41, P143, DOI 10.1002/eat.20478
   Lopez CA, 2008, J CLIN EXP NEUROPSYC, V4, P1
   Lopez CA, 2008, INT J EAT DISORDER, V41, P340, DOI 10.1002/eat.20511
   Losh M, 2007, J CHILD PSYCHOL PSYC, V48, P105, DOI 10.1111/j.1469-7610.2006.01594.x
   Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
   Mathers C., 1999, MJA, V172, P592
   Matsunaga H, 1998, INT J EAT DISORDER, V23, P399
   Mayer JD, 2000, HDB INTELLIGENCE, P396
   Mazzeo SE, 2009, PSYCHOL MED, V40, P1203
   McAnarney E. R., 2010, J ADOLESCENT HEALTH, V49, P99
   MCLAUGHLIN EF, 1985, INT J EAT DISORDER, V4, P511, DOI 10.1002/1098-108X(198511)4:4<511::AID-EAT2260040411>3.0.CO;2-Z
   Miller EK, 2001, ANNU REV NEUROSCI, V24, P167, DOI 10.1146/annurev.neuro.24.1.167
   Milner B., 1963, ARCH NEUROL-CHICAGO, V9, P100, DOI DOI 10.1001/ARCHNEUR.1963.00460070100010
   Mobbs O, 2008, PERS INDIV DIFFER, V45, P602, DOI 10.1016/j.paid.2008.06.021
   Monk CS, 2008, AM J PSYCHIAT, V165, P90
   Nakazato M, 2010, AN GEN PSYCHIAT, V9, P1
   Nakazato M, 2008, PSYCHOL MED, V39, P1029
   Namyslowska I., 2009, EUR PSYCH C 17 EUR P
   NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3
   Ohrmann P, 2004, NEUROREPORT, V15, P549, DOI 10.1097/01.wnr.0000109798.20952.46
   Oldershaw A, 2011, NEUROSCI BIOBEHAV R, V35, P970, DOI 10.1016/j.neubiorev.2010.11.001
   Oldershaw A, 2010, PSYCHOSOM MED, V72, P73, DOI 10.1097/PSY.0b013e3181c6c7ca
   Osterrieth P, 1944, ARCH PSYCHOL, V30, P206
   OZONOFF S, 1993, J AUTISM DEV DISORD, V23, P429, DOI 10.1007/BF01046049
   Pessoa L, 2002, COGNITIVE BRAIN RES, V15, P31, DOI 10.1016/S0926-6410(02)00214-8
   Phelps EA, 2004, NEURON, V43, P897, DOI 10.1016/j.neuron.2004.08.042
   Phillips ML, 1997, NATURE, V389, P495, DOI 10.1038/39051
   Quirk GJ, 2006, CURR OPIN NEUROBIOL, V16, P723, DOI 10.1016/j.conb.2006.07.004
   Rada P, 2005, NEUROSCIENCE, V134, P737, DOI 10.1016/j.neuroscience.2005.04.043
   Ravizza SM, 2008, NEUROPSYCHOLOGIA, V46, P2924, DOI 10.1016/j.neuropsychologia.2008.06.006
   Reitan RM, 1955, J CONSULT PSYCHOL, V19, P393, DOI 10.1037/h0044509
   Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305
   Riveros R, 2010, SCHIZOPHR RES, V116, P297, DOI 10.1016/j.schres.2009.10.017
   Robbins TW, 2005, J COMP NEUROL, V493, P140, DOI 10.1053/cne.20717
   Roberts M., 2009, WORLD J BIOL PSYCHIA
   Roberts ME, 2010, J PSYCHIATR RES, V44, P964, DOI 10.1016/j.jpsychires.2010.03.001
   Roberts ME, 2012, WORLD J BIOL PSYCHIA
   Roberts ME, 2007, PSYCHOL MED, V37, P1075, DOI 10.1017/S0033291707009877
   Roman T, 2001, AM J MED GENET, V105, P471, DOI 10.1002/ajmg.1408
   Rose M., 2011, EUROPEAN EATING DISO, V20, P32
   Russell TA, 2009, PSYCHIAT RES, V168, P181, DOI 10.1016/j.psychres.2008.10.028
   Saarni C., 1990, SOCIOEMOTIONAL DEV, V36, P115
   Savage CR, 1999, BIOL PSYCHIAT, V45, P905, DOI 10.1016/S0006-3223(98)00278-9
   Schmidt U, 2006, BRIT J CLIN PSYCHOL, V45, P343, DOI 10.1348/014466505X53902
   Seidman LJ, 2000, J ABNORM PSYCHOL, V109, P252, DOI 10.1037//0021-843X.109.2.252
   Sherman BJ, 2006, INT J EAT DISORDER, V39, P468, DOI 10.1002/eat.20300
   Sitskoom MM, 2004, SCHIZOPHR RES, V71, P285, DOI 10.1016/j.schres.2004.03.007
   Slaats-Willemse DIE, 2007, NEUROPSYCHOLOGY, V21, P751, DOI 10.1037/0894-4105.21.6.751
   SMALLEY SL, 1989, BEHAV GENET, V19, P229, DOI 10.1007/BF01065907
   Starcke K, 2011, PSYCHONEUROENDOCRINO, V36, P210, DOI 10.1016/j.psyneuen.2010.07.010
   Steinglass J, 2006, INT J EAT DISORDER, V39, P267, DOI 10.1002/eat.20244
   Steinglass JE, 2006, J INT NEUROPSYCH SOC, V12, P431, DOI 10.1017/S1355617706060528
   Steinhausen HC, 2009, AM J PSYCHIAT, V166, P1331, DOI 10.1176/appi.ajp.2009.09040582
   Steinhausen HC, 2002, AM J PSYCHIAT, V159, P1284, DOI 10.1176/appi.ajp.159.8.1284
   Sumiyoshi C, 2011, NEUROSCI RES, V69, P252, DOI 10.1016/j.neures.2010.11.007
   Sunday SR, 1996, J YOUTH ADOLESCENCE, V25, P533, DOI 10.1007/BF01537547
   Surguladze SA, 2010, NEUROIMAGE, V53, P58, DOI 10.1016/j.neuroimage.2010.05.069
   Svaldi J., 2009, APPETITE, V54, P84
   SZATMARI P, 1993, J AM ACAD CHILD PSY, V32, P1264, DOI 10.1097/00004583-199311000-00022
   Szoke A, 2006, PSYCHIAT RES, V144, P131, DOI 10.1016/j.psychres.2005.11.013
   Takahashi M, 2006, PSYCHIAT CLIN NEUROS, V60, P211, DOI 10.1111/j.1440-1819.2006.01488.x
   Tchanturia K, 2012, PLOS ONE, V7, P1
   Tchanturia K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020462
   Tchanturia K, 2004, J PSYCHIAT RES, V38, P545, DOI 10.1016/j.jphyschires.2004.03.001
   Tchanturia K, 2007, J INT NEUROPSYCH SOC, V13, P635, DOI 10.1017/S1355617707070798
   Tenconi E, 2010, WORLD J BIOL PSYCHIA, V11, P813, DOI 10.3109/15622975.2010.483250
   Thompson JL, 2005, SCHIZOPHRENIA BULL, V31, P85, DOI 10.1093/schbul/sbi009
   Thompson S. B. N, 1993, EUROPEAN EATING DISO, V1, P152, DOI 10.1002/erv.2400010304
   Tiller JM, 1997, INT J EAT DISORDER, V21, P31
   Tokley M, 2007, J CLIN EXP NEUROPSYC, V29, P734, DOI 10.1080/13825580600966607
   Treasure J, 2007, PEDIAT HLTH, V1, P171, DOI 10.2217/17455111.1.2.171
   Treasure J, 2010, LANCET, V375, P583, DOI 10.1016/S0140-6736(09)61748-7
   Treasure JL, 2008, BRIT J PSYCHIAT, V192, P243, DOI 10.1192/bjp.bp.107.044164
   Trivedi JK, 2008, PSYCHIAT CLIN NEUROS, V62, P190, DOI 10.1111/j.1440-1819.2008.01754.x
   Tugade MM, 2002, EMO SOC BEH, P319
   Uebel H, 2010, J CHILD PSYCHOL PSYC, V51, P210, DOI 10.1111/j.1469-7610.2009.02139.x
   Uher R, 2004, AM J PSYCHIAT, V161, P1238, DOI 10.1176/appi.ajp.161.7.1238
   Urry HL, 2006, J NEUROSCI, V26, P4415, DOI 10.1523/JNEUROSCI.3215-05.2006
   Van den Eynde F, 2011, ACTA PSYCHIAT SCAND, V124, P120, DOI 10.1111/j.1600-0447.2011.01701.x
   Wagner A, 2007, AM J PSYCHIAT, V164, P1842, DOI 10.1176/appi.ajp.2007.07040575
   Wagner A, 2010, INT J EAT DISORDER, V43, P289, DOI 10.1002/eat.20699
   Ward A, 2000, INT J EAT DISORDER, V28, P370, DOI 10.1002/1098-108X(200012)28:4<370::AID-EAT4>3.0.CO;2-P
   Wentz E, 2009, BRIT J PSYCHIAT, V194, P168, DOI 10.1192/bjp.bp.107.048686
   Wentz E, 2005, EUR CHILD ADOLES PSY, V14, P431, DOI 10.1007/s00787-005-0494-3
   Witkin H. A., 2002, GROUP EMBEDDED FIGUR
   Witkin H. A., 1962, PSYCHOL DIFFERENTIAT
   Young AW, 2002, FACIAL EXPRESSIONS E
   Zalla T, 2004, PSYCHIAT RES, V121, P207, DOI 10.1016/S0165-1781(03)00252-X
   Zastrow A, 2009, AM J PSYCHIAT, V166, P608, DOI 10.1176/appi.ajp.2008.08050775
   Zucker NL, 2007, PSYCHOL BULL, V133, P976, DOI 10.1037/0033-2909.133.6.976
NR 221
TC 2
Z9 2
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 1354-6805
J9 COGN NEUROPSYCHIATRY
JI Cogn. Neuropsychiatry
PD JAN 1
PY 2013
VL 18
IS 1-2
SI SI
BP 83
EP 114
DI 10.1080/13546805.2012.682362
PG 32
WC Psychiatry
SC Psychiatry
GA 110LQ
UT WOS:000316444200005
PM 22994309
ER

PT J
AU Kato, TA
   Yamauchi, Y
   Horikawa, H
   Monji, A
   Mizoguchi, Y
   Seki, Y
   Hayakawa, K
   Utsumi, H
   Kanba, S
AF Kato, T. A.
   Yamauchi, Y.
   Horikawa, H.
   Monji, A.
   Mizoguchi, Y.
   Seki, Y.
   Hayakawa, K.
   Utsumi, H.
   Kanba, S.
TI Neurotransmitters, Psychotropic Drugs and Microglia: Clinical
   Implications for Psychiatry
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Microglia; antipsychotics; antidepressants; antiepileptics; minocycline;
   BDNF; dopamine; serotonin; norepinephrine; schizophrenia; depression;
   epilepsy; psychiatry
ID METABOTROPIC GLUTAMATE RECEPTORS; NECROSIS-FACTOR-ALPHA; NICOTINIC
   ACETYLCHOLINE-RECEPTOR; PROTECTS DOPAMINERGIC-NEURONS; MAJOR DEPRESSIVE
   DISORDER; NITRIC-OXIDE PRODUCTION; AMYLOID-BETA PEPTIDE; RISK MENTAL
   STATE; VALPROIC ACID; ALZHEIMERS-DISEASE
AB Psychiatric disorders have long and dominantly been regarded to be induced by disturbances of neuronal networks including synapses and neurotransmitters. Thus, the effects of psychotropic drugs such as antipsychotics and antidepressants have been understood to modulate synaptic regulation via receptors and transporters of neurotransmitters such as dopamine and serotonin. Recently, microglia, immunological/inflammatory cells in the brain, have been indicated to have positive links to psychiatric disorders. Positron emission tomography (PET) imaging and postmortem studies have revealed microglial activation in the brain of neuropsychiatric disorders such as schizophrenia, depression and autism. Animal models of neuropsychiatric disorders have revealed the underlying microglial pathologies. In addition, various psychotropic drugs have been suggested to have direct effects on microglia. Until now, the relationship between microglia, neurotransmitters and psychiatric disorders has not been well understood. Therefore, in this review, at first, we summarize recent findings of interaction between microglia and neurotransmitters such as dopamine, serotonin, norepinephrine, acetylcholine and glutamate. Next, we introduce up-to-date knowledge of the effects of psychotropic drugs such as antipsychotics, antidepressants and antiepileptics on microglial modulation. Finally, we propose the possibility that modulating microglia may be a key target in the treatment of various psychiatric disorders. Further investigations and clinical trials should be conducted to clarify this perspective, using animal in vivo studies and imaging studies with human subjects.
C1 [Kato, T. A.; Yamauchi, Y.; Horikawa, H.; Hayakawa, K.; Kanba, S.] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka 8128582, Japan.
   [Kato, T. A.; Utsumi, H.] Kyushu Univ, Innovat Ctr Med Redox Nav, Fukuoka 8128582, Japan.
   [Monji, A.; Mizoguchi, Y.; Seki, Y.] Saga Univ, Fac Med, Dept Psychiat, Saga 8498501, Japan.
RP Kato, TA (reprint author), Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM takahiro@npsych.med.kyushu-u.ac.jp; amonji@hf.rim.or.jp
FU Japan Society for the Promotion of Science (JSPS)
FX This work was financially supported by Grant-in-Aid from the Japan
   Society for the Promotion of Science (JSPS) to TAK and SK.
CR Acarin L, 2002, J NEUROSCI RES, V68, P745, DOI 10.1002/jnr.10261
   Ahuja N, 2007, PROG NEURO-PSYCHOPH, V31, P968, DOI 10.1016/j.pnpbp.2007.01.018
   Angelucci F, 2005, MOL PSYCHIATR, V10, P345, DOI 10.1038/sj.mp.4001637
   Anisman H, 2009, J PSYCHIATR NEUROSCI, V34, P4
   Avignone E, 2008, J NEUROSCI, V28, P9133, DOI 10.1523/JNEUROSCI.1820-08.2008
   Baptiste DC, 2006, J NEUROTRAUM, V23, P318, DOI 10.1089/neu.2006.23.318
   Batchelor PE, 1999, J NEUROSCI, V19, P1708
   Berridge CW, 2012, SLEEP MED REV, V16, P187, DOI 10.1016/j.smrv.2011.12.003
   Berton O, 2006, NAT REV NEUROSCI, V7, P137, DOI 10.1038/nrn1846
   Beschorner R, 2007, HISTOL HISTOPATHOL, V22, P515
   Beschorner R, 2007, HISTOPATHOLOGY, V50, P897, DOI 10.1111/j.1365-2559.2007.02703.x
   Bian Q, 2008, PROG NEURO-PSYCHOPH, V32, P42, DOI 10.1016/j.pnpbp.2007.06.031
   Biber K, 1999, J NEUROCHEM, V72, P1671, DOI 10.1046/j.1471-4159.1999.721671.x
   Bilousova TV, 2009, J MED GENET, V46, P94, DOI 10.1136/jmg.2008.061796
   Black JA, 2009, GLIA, V57, P1072, DOI 10.1002/glia.20830
   Black JA, 2007, ANN NEUROL, V62, P21, DOI 10.1002/ana.21172
   BLISS TVP, 1993, NATURE, V361, P31, DOI 10.1038/361031a0
   Borgwardt S, 2011, SCHIZOPHR RES, V133, P63, DOI 10.1016/j.schres.2011.08.021
   Borgwardt S, 2012, BRIT J PSYCHIAT, V200, P270, DOI 10.1192/bjp.bp.111.103234
   Borgwardt SJ, 2006, J NEUROL NEUROSUR PS, V77, P229, DOI 10.1136/jnnp.2005.069690
   Borgwardt SJ, 2009, SCHIZOPHR RES, V112, P32, DOI 10.1016/j.schres.2009.04.025
   Buehlmann E, 2010, J PSYCHIATR RES, V44, P447, DOI 10.1016/j.jpsychires.2009.10.008
   Burris KD, 2002, J PHARMACOL EXP THER, V302, P381, DOI 10.1124/jpet.102.033175
   Chang Y, 2009, MEDIAT INFLAMM, DOI 10.1155/2009/705379
   Chaudhry I. B., 2012, J PSYCHOPHARMACOL
   Chaves C, 2010, PROG NEURO-PSYCHOPH, V34, P550, DOI 10.1016/j.pnpbp.2010.01.020
   Chen PS, 2007, NEUROSCIENCE, V149, P203, DOI 10.1016/j.neuroscience.2007.06.053
   Choi J, 2009, J NEUROINFLAMM, V6, DOI 10.1186/1742-2094-6-38
   Choi SH, 2003, J NEUROSCI, V23, P5877
   Christensen RN, 2006, J NEUROSCI RES, V84, P170, DOI 10.1002/jnr.20865
   Chung ES, 2010, BRAIN RES, V1363, P143, DOI 10.1016/j.brainres.2010.09.049
   Chung YC, 2011, NEUROPHARMACOLOGY, V60, P963, DOI 10.1016/j.neuropharm.2011.01.043
   Cipriani A, 2009, LANCET, V373, P746, DOI 10.1016/S0140-6736(09)60046-5
   Coull JAM, 2005, NATURE, V438, P1017, DOI 10.1038/nature04223
   Craner MJ, 2005, GLIA, V49, P220, DOI 10.1002/glia.20112
   Daulhac L., 2011, EUR J PAIN, V15
   De Simone R, 2005, J NEUROINFLAMM, V2, DOI 10.1186/1742-2094-2-4
   Defaux A, 2011, NEUROSCIENCE, V187, P84, DOI 10.1016/j.neuroscience.2011.04.053
   Dello Russo C, 2004, J NEUROINFLAMM, V1, DOI 10.1186/1742-2094-1-9
   Derecki NC, 2012, NATURE, V484, P105, DOI 10.1038/nature10907
   Derecki NC, 2010, J EXP MED, V207, P1067, DOI 10.1084/jem.20091419
   De Simoni MG, 2000, EUR J NEUROSCI, V12, P2623, DOI 10.1046/j.1460-9568.2000.00140.x
   Dingledine R, 1999, PHARMACOL REV, V51, P7
   Domercq M, 2004, TRENDS PHARMACOL SCI, V25, P609, DOI 10.1016/j.tips.2004.10.001
   Doorduin J, 2009, J NUCL MED, V50, P1801, DOI 10.2967/jnumed.109.066647
   Dowlati Y., 2009, BIOL PSYCHIAT, V67, P446
   Dragunow M, 2006, NEUROSCIENCE, V140, P1149, DOI 10.1016/j.neuroscience.2006.02.065
   Duman RS, 2006, BIOL PSYCHIAT, V59, P1116, DOI 10.1016/j.biopsych.2006.02.013
   Elkabes S, 1996, J NEUROSCI, V16, P2508
   Farber K, 2005, MOL CELL NEUROSCI, V29, P128, DOI 10.1016/j.mcn.2005.01.003
   Farber NB, 1998, PROG BRAIN RES, V116, P421, DOI 10.1016/S0079-6123(08)60453-7
   Farso MC, 2009, NEUROCHEM RES, V34, P1721, DOI 10.1007/s11064-009-9999-3
   Ferraguti F, 2006, CELL TISSUE RES, V326, P483, DOI 10.1007/s00441-006-0266-5
   FONNUM F, 1984, J NEUROCHEM, V42, P1, DOI 10.1111/j.1471-4159.1984.tb09689.x
   Fujita Y, 2008, PROG NEURO-PSYCHOPH, V32, P336, DOI 10.1016/j.pnpbp.2007.08.031
   Fusar-Poli P, 2007, NEUROSCI BIOBEHAV R, V31, P465, DOI 10.1016/j.neubiorev.2006.11.006
   Fusar-Poli P., 2011, EUR PSYCHIA IN PRESS
   Fusar-Poli P, 2011, NEUROSCI BIOBEHAV R, V35, P1175, DOI 10.1016/j.neubiorev.2010.12.005
   Fusar-Poli P., 2012, WORLD J BIOL PSYCHIA
   Fusar-Poli P, 2011, SCHIZOPHR B IN PRESS
   Gibbons HM, 2011, NEUROBIOL DIS, V41, P96, DOI 10.1016/j.nbd.2010.08.024
   Goddard AW, 2010, DEPRESS ANXIETY, V27, P339, DOI 10.1002/da.20642
   Goff DC, 2001, AM J PSYCHIAT, V158, P1367, DOI 10.1176/appi.ajp.158.9.1367
   Graeber MB, 2010, ACTA NEUROPATHOL, V119, P89, DOI 10.1007/s00401-009-0622-0
   Graeber MB, 2010, SCIENCE, V330, P783, DOI 10.1126/science.1190929
   Ha KY, 2008, EUR SPINE J, V17, P864, DOI 10.1007/s00586-008-0653-6
   Hagino Y, 2004, GLIA, V47, P68, DOI 10.1002/glia.20034
   Haller S, 2009, RADIOLOGY, V250, P212, DOI 10.1148/radiol.2501072153
   Hashimoto K, 2010, PSYCHIAT CLIN NEUROS, V64, P341, DOI 10.1111/j.1440-1819.2010.02113.x
   Hashioka S, 2007, EXP NEUROL, V206, P33, DOI 10.1016/j.expneurol.2007.03.022
   Heneka MT, 2010, P NATL ACAD SCI USA, V107, P6058, DOI 10.1073/pnas.0909586107
   Heneka MT, 2010, J NEURAL TRANSM, V117, P919, DOI 10.1007/s00702-010-0438-z
   Henry CJ, 2008, J NEUROINFLAMM, V5, DOI 10.1186/1742-2094-5-15
   Hewett SJ, 2000, J PHARMACOL EXP THER, V293, P417
   Horikawa H, 2010, PROG NEURO-PSYCHOPH, V34, P1306, DOI 10.1016/j.pnpbp.2010.07.015
   Hou Y, 2006, PROG NEURO-PSYCHOPH, V30, P1523, DOI 10.1016/j.pnpbp.2006.05.006
   Howes O., 2011, MOL PSYCHIAT
   Howes Oliver D, 2007, Br J Psychiatry Suppl, V51, ps13, DOI 10.1192/bjp.191.51.s13
   Hu XM, 2012, J NEUROIMMUNE PHARM, V7, P187, DOI 10.1007/s11481-011-9309-0
   Hurlock EC, 2001, MED HYPOTHESES, V56, P558, DOI 10.1054/mehy.2000.1218
   Hwang J, 2008, NEUROPHARMACOLOGY, V55, P826, DOI 10.1016/j.neuropharm.2008.06.045
   Jeon HJ, 2012, PROG NEURO-PSYCHOPH, V38, P149, DOI 10.1016/j.pnpbp.2012.03.002
   Juckel G, 2011, SCHIZOPHR RES, V131, P96, DOI 10.1016/j.schres.2011.06.018
   Kalinin S, 2007, NEUROBIOL AGING, V28, P1206, DOI 10.1016/j.neurobiolaging.2006.06.003
   Kan AA, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-207
   Kapur S, 2003, PROG NEURO-PSYCHOPH, V27, P1081, DOI 10.1016/j.pnpbp.2003.09.004
   Kato T, 2008, J NEUROCHEM, V106, P815, DOI 10.1111/j.1471-4159.2008.05435.x
   Kato T, 2007, SCHIZOPHR RES, V92, P108, DOI 10.1016/j.schres.2007.01.019
   Kato TA, 2011, SCHIZOPHR RES, V129, P172, DOI 10.1016/j.schres.2011.03.019
   Kato TA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040461
   Kato TA, 2011, MINI-REV MED CHEM, V11, P565
   Kelly D. L., 2011, SCHIZOPHR RES, V133, P257
   Keshavan MS, 2011, SCHIZOPHR RES, V127, P3, DOI 10.1016/j.schres.2011.01.011
   Kettenmann H, 2011, PHYSIOL REV, V91, P461, DOI 10.1152/physrev.00011.2010
   Kim HJ, 2007, J PHARMACOL EXP THER, V321, P892, DOI 10.1124/jpet.107.120188
   Kim HS, 2009, BEHAV BRAIN RES, V196, P168, DOI 10.1016/j.bbr.2008.09.040
   KIM JS, 1980, NEUROSCI LETT, V20, P379, DOI 10.1016/0304-3940(80)90178-0
   Kong Y, 2010, J NEUROSCI, V30, P11848, DOI 10.1523/JNEUROSCI.2985-10.2010
   Kowalski J, 2003, NEUROCHEM INT, V43, P173, DOI 10.1016/S0197-0186(02)00163-8
   Kowalski J, 2004, POL J PHARMACOL, V56, P563
   Krabbe G, 2012, BRAIN BEHAV IMMUN, V26, P419, DOI 10.1016/j.bbi.2011.12.002
   Kraeplin E., 1919, DEMENTIA PRAECOX PAR
   Labuzek K, 2005, EUR NEUROPSYCHOPHARM, V15, P23, DOI 10.1016/j.euroneuro.2004.04.002
   Lee A, 2010, INT J BIOCHEM CELL B, V42, P1901, DOI 10.1016/j.biocel.2010.09.016
   Levkovitz Y, 2010, J CLIN PSYCHIAT, V71, P138, DOI 10.4088/JCP.08m04666yel
   Li Y, 2008, NEURON, V59, P399, DOI 10.1016/j.neuron.2008.06.023
   Liaury K, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-56
   Lim CM, 2009, J NEUROSCI RES, V87, P1037, DOI 10.1002/jnr.21899
   LIPTON SA, 1994, NEW ENGL J MED, V330, P613
   Liu DX, 2011, NEUROPHARMACOLOGY, V61, P592, DOI 10.1016/j.neuropharm.2011.04.033
   Liu GJ, 2009, EUR J NEUROSCI, V29, P1108, DOI 10.1111/j.1460-9568.2009.06659.x
   Liu J, 2009, INVEST OPHTH VIS SCI, V50, P1408, DOI 10.1167/iovs.08-2398
   Liu Y, 2012, J AFFECT DISORDERS, V139, P230, DOI 10.1016/j.jad.2011.08.003
   Lopez-Redondo F, 2000, MOL BRAIN RES, V76, P429, DOI 10.1016/S0169-328X(00)00022-X
   Macdowell KS, 2011, INT J NEUROPSYCHOPH, P1
   Manji HK, 2001, NAT MED, V7, P541, DOI 10.1038/87865
   Mastroeni D, 2009, NEUROBIOL AGING, V30, P1805, DOI 10.1016/j.neurobiolaging.2008.01.001
   Matsumoto K, 2011, METHODS MOL BIOL, V711, P397, DOI 10.1007/978-1-61737-992-5_20
   McNamee EN, 2010, EUR J PHARMACOL, V626, P219, DOI 10.1016/j.ejphar.2009.09.054
   Mei XP, 2011, NEUROSIGNALS, V19, P44, DOI 10.1159/000324293
   Meyer U, 2010, SCHIZOPHRENIA BULL, V36, P607, DOI 10.1093/schbul/sbn131
   Meyer U, 2008, BRAIN BEHAV IMMUN, V22, P469, DOI 10.1016/j.bbi.2007.09.012
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   MINAMI M, 1991, BIOCHEM BIOPH RES CO, V176, P593, DOI 10.1016/S0006-291X(05)80225-6
   Minichiello L, 2009, NAT REV NEUROSCI, V10, P850, DOI 10.1038/nrn2738
   Miyamoto S, 2005, MOL PSYCHIATR, V10, P79, DOI 10.1038/sj.mp.4001556
   Miyaoka T, 2008, CNS NEUROL DISORD-DR, V7, P376, DOI 10.2174/187152708786441858
   Miyaoka T, 2007, PROG NEURO-PSYCHOPH, V31, P304, DOI 10.1016/j.pnpbp.2006.08.013
   Mizoguchi H, 2008, PSYCHOPHARMACOLOGY, V196, P233, DOI 10.1007/s00213-007-0955-0
   Mizoguchi Y, 2011, MINI-REV MED CHEM, V11, P575
   Mizoguchi Y, 2009, J IMMUNOL, V183, P7778, DOI 10.4049/jimmunol.0901326
   Monji A, 2011, PROG NEUROPSYCHOPHAR
   Monji A, 2009, PSYCHIAT CLIN NEUROS, V63, P257
   Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
   Mori K, 2002, NEUROPHARMACOLOGY, V43, P1026, DOI 10.1016/S0028-3908(02)00211-3
   Morimoto S, 2012, J PHARMACOL SCI, V118, P455, DOI 10.1254/jphs.11102FP
   Morioka N, 2009, NEUROCHEM INT, V55, P226, DOI 10.1016/j.neuint.2009.03.004
   Müller N, 2007, Mol Psychiatry, V12, P988, DOI 10.1038/sj.mp.4002006
   Muller N, 2004, EXPERT OPIN INV DRUG, V13, P1033, DOI 10.1517/13543784.13.8.1033
   Muller N, 2004, EUR ARCH PSY CLIN N, V254, P14, DOI 10.1007/s00406-004-0478-1
   Muller N, 2008, CURR PHARM DESIGN, V14, P1452, DOI 10.2174/138161208784480243
   Muller N, 2010, SCHIZOPHR RES, V121, P118, DOI 10.1016/j.schres.2010.04.015
   Müller Norbert, 2009, Dialogues Clin Neurosci, V11, P319
   MULLEROERLINGHAUSEN B, 1992, J AFFECT DISORDERS, V25, P261, DOI 10.1016/0165-0327(92)90084-J
   Murugan M, 2011, GLIA, V59, P521, DOI 10.1002/glia.21121
   Najjar S, 2011, NEUROLOGIST, V17, P249, DOI 10.1097/NRL.0b013e31822aad04
   Nakajima K, 2001, J NEUROSCI RES, V65, P322, DOI 10.1002/jnr.1157
   Noda M, 2000, J NEUROSCI, V20, P251
   Obuchowicz E, 2006, INT J NEUROPSYCHOPH, V9, P27, DOI 10.1017/S146114570500547X
   O'Connor JC, 2009, MOL PSYCHIATR, V14, P511, DOI 10.1038/sj.mp.4002148
   Olanow CW, 1999, ANNU REV NEUROSCI, V22, P123, DOI 10.1146/annurev.neuro.22.1.123
   OLNEY JW, 1995, ARCH GEN PSYCHIAT, V52, P998
   Peng GS, 2005, MOL BRAIN RES, V134, P162, DOI 10.1016/j.molbrainres.2004.10.021
   Picciotto MR, 2000, NEUROPSYCHOPHARMACOL, V22, P451, DOI 10.1016/S0893-133X(99)00146-3
   Pickar D, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003150
   Plane JM, 2010, ARCH NEUROL-CHICAGO, V67, P1442, DOI [10.1001/archneurol.2010.191, 10.1001/archneuro1.2010.191]
   Pocock JM, 2007, TRENDS NEUROSCI, V30, P527, DOI 10.1016/j.tins.2007.07.007
   Poo MM, 2001, NAT REV NEUROSCI, V2, P24, DOI 10.1038/35049004
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Reisberg B, 2003, NEW ENGL J MED, V348, P1333, DOI 10.1056/NEJMoa013128
   Riazi K, 2008, P NATL ACAD SCI USA, V105, P17151, DOI 10.1073/pnas.0806682105
   Rock RB, 2008, J NEUROIMMUNE PHARM, V3, P143, DOI 10.1007/s11481-007-9098-7
   Rose CR, 2003, NATURE, V426, P74, DOI 10.1038/nature01983
   Rosi S, 2006, NEUROSCIENCE, V142, P1303, DOI 10.1016/j.neuroscience.2006.08.017
   Rothlisberger M, 2012, CURR PHARM DESIGN, V18, P495
   Salvadore G, 2009, BIOL PSYCHIAT, V65, P289, DOI 10.1016/j.biopsych.2008.08.014
   Sara SJ, 2009, NAT REV NEUROSCI, V10, P211, DOI 10.1038/nrn2573
   Schiepers OJG, 2005, PROG NEURO-PSYCHOPH, V29, P201, DOI 10.1016/j.pnpbp.2004.11.003
   Schlachetzki JCM, 2010, J NEUROINFLAMM, V7, DOI 10.1186/1742-2094-7-2
   Schwarz MJ, 2001, MED HYPOTHESES, V56, P483, DOI 10.1054/mehy.2000.1203
   Schwarz MJ, 2001, BRAIN BEHAV IMMUN, V15, P340, DOI 10.1006/brbi.2001.0647
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Shad M. U., 2011, HUM PSYCHOPHARMACOL
   Shapiro DA, 2003, NEUROPSYCHOPHARMACOL, V28, P1400, DOI 10.1038/sj.npp.1300203
   Shiba T, 2011, NEUROIMAGE, V57, P866, DOI 10.1016/j.neuroimage.2011.05.041
   Shimizu E, 2000, SCIENCE, V290, P1170, DOI 10.1126/science.290.5494.1170
   Sim K, 2011, INT J NEUROPSYCHOPH, V14, P1157, DOI 10.1017/S1461145711000563
   Smieskova R, 2009, CURR PHARM DESIGN, V15, P2535
   Smieskova R, 2012, CURR PHARM DESIGN, V18, P416
   Smieskova R, 2010, NEUROSCI BIOBEHAV R, V34, P1207, DOI 10.1016/j.neubiorev.2010.01.016
   Smieskova R, 2012, PSYCHOL MED, V42, P1613, DOI 10.1017/S0033291711002716
   Smith AM, 2010, NEUROSCIENCE, V169, P505, DOI 10.1016/j.neuroscience.2010.04.041
   SMITH WL, 1995, SEMIN NEPHROL, V15, P179
   SMITH WL, 1991, PHARMACOL THERAPEUT, V49, P153, DOI 10.1016/0163-7258(91)90054-P
   Steiner J, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-94
   Steiner J, 2008, J PSYCHIATR RES, V42, P151, DOI 10.1016/j.jpsychires.2006.10.013
   Steiner J, 2006, ACTA NEUROPATHOL, V112, P305, DOI 10.1007/s00401-006-0090-8
   Steininger TS, 2011, BRAIN RES, V1407, P1, DOI 10.1016/j.brainres.2011.06.050
   Stirling DP, 2005, NEUROSCIENTIST, V11, P308, DOI 10.1177/1073858405275175
   Stone JM, 2009, CURR PHARM DESIGN, V15, P2594
   Suh H. S., 2010, J NEUROIMMUNE PHARM, V5, P521
   Suzuki T, 2006, J NEUROSCI RES, V83, P1461, DOI 10.1002/jnr.20850
   Takano A, 2010, INT J NEUROPSYCHOPH, V13, P943, DOI 10.1017/S1461145710000313
   Tanaka KF, 2002, J NEUROSCI RES, V70, P232, DOI 10.1002/jnr.10399
   Taylor DL, 2003, J NEUROSCI, V23, P2150
   Taylor DL, 2002, J NEUROCHEM, V82, P1179, DOI 10.1046/j.1471-4159.2002.01062.x
   Tetreault NA, 2012, J AUTISM DEV DISORD
   ThiesFlechtner K, 1996, PHARMACOPSYCHIATRY, V29, P103, DOI 10.1055/s-2007-979553
   Turrin NP, 2004, NEUROBIOL DIS, V16, P321, DOI 10.1016/j.nbd.2004.03.010
   Tynan RJ, 2012, BRAIN BEHAV IMMUN, V26, P469, DOI 10.1016/j.bbi.2011.12.011
   Tyring S, 2006, LANCET, V367, P29, DOI 10.1016/S0140-6736(05)67763-X
   Uguz F, 2009, PSYCHIAT CLIN NEUROS, V63, P50, DOI 10.1111/j.1440-1819.2008.01905.x
   Vallat-Decouvelaere AV, 2003, J NEUROPATH EXP NEUR, V62, P475
   van Berckel BN, 2008, BIOL PSYCHIAT, V64, P820, DOI 10.1016/j.biopsych.2008.04.025
   van Gool WA, 2010, LANCET, V375, P773, DOI 10.1016/S0140-6736(09)61158-2
   Van Landeghem FKH, 2001, GLIA, V35, P167, DOI 10.1002/glia.1082
   Ventriglio A, 2011, INT CLIN PSYCHOPHARM, V26, P88, DOI 10.1097/YIC.0b013e328340c0de
   Vezzani A., 2011, EXP NEUROL
   Vollmar P, 2008, INT J NEUROPSYCHOPH, V11, P111, DOI 10.1017/S1461145707007729
   Wang H, 2003, NATURE, V421, P384, DOI 10.1038/nature01339
   Watabe M, 2012, PSYCHOPHARMACOLOGY, V220, P551, DOI 10.1007/s00213-011-2509-8
   Wohleb ES, 2011, J NEUROSCI, V31, P6277, DOI 10.1523/JNEUROSCI.0450-11.2011
   Wu HM, 2009, NEUROPSYCHOPHARMACOL, V34, P2344, DOI 10.1038/npp.2009.64
   Xiao L, 2008, MOL PSYCHIATR, V13, P697, DOI 10.1038/sj.mp.4002064
   Xie NC, 2010, NEUROSCI LETT, V482, P51, DOI 10.1016/j.neulet.2010.07.004
   Xing HQ, 2009, J NEUROPATH EXP NEUR, V68, P199, DOI 10.1097/NEN.0b013e31819715df
   Xiong ZQ, 2003, J NEUROSCI, V23, P955
   Xuan AG, 2012, LIFE SCI, V90, P463, DOI 10.1016/j.lfs.2012.01.001
   Yang JH, 2012, EXP NEUROL, V236, P199, DOI 10.1016/j.expneurol.2012.05.008
   Yang JL, 2012, MOL BRAIN, V5, DOI 10.1186/1756-6606-5-18
   Yokoyama H, 2010, METAB BRAIN DIS, V25, P305, DOI 10.1007/s11011-010-9212-z
   Zarate CA, 2006, ARCH GEN PSYCHIAT, V63, P856, DOI 10.1001/archpsyc.63.8.856
   Zhang JM, 2003, EXP NEUROL, V183, P469, DOI 10.1016/S0014-4886(03)00222-X
   Zhang L, 2007, NEUROPSYCHOPHARMACOL, V32, P2004, DOI 10.1038/sj.npp.1301313
   Zhang YB, 2012, SCHIZOPHR RES, V138, P8, DOI 10.1016/j.schres.2012.04.006
   Zhang YB, 2008, SCHIZOPHR RES, V106, P182, DOI 10.1016/j.schres.2008.09.013
   Zhang Z, 2008, CELL MOL LIFE SCI, V65, P4055, DOI 10.1007/s00018-008-8521-4
   Zheng LT, 2008, J NEUROCHEM, V107, P1225, DOI 10.1111/j.1471-4159.2008.05675.x
NR 228
TC 6
Z9 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD JAN
PY 2013
VL 20
IS 3
BP 331
EP 344
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 112QU
UT WOS:000316608400003
PM 23157624
ER

PT J
AU Dawson, G
AF Dawson, Geraldine
TI Dramatic Increase in Autism Prevalence Parallels Explosion of Research
   Into Its Biology and Causes
SO JAMA PSYCHIATRY
LA English
DT Editorial Material
C1 [Dawson, Geraldine] Univ N Carolina, Dept Psychiat, Autism Speaks, Chapel Hill, NC USA.
RP Dawson, G (reprint author), Univ N Carolina, Dept Psychiat, Carolina Inst Dev Disabil, 101 Renee Lynne Ct, Carrboro, NC 27510 USA.
EM gdawson@autismspeaks.org
CR Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Ecker C, 2013, JAMA PSYCHIAT, V70, P59, DOI 10.1001/jamapsychiatry.2013.265
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Interagency Autism Coordinating Committee US Department of Health & Human Services, 2012, IACC OARC AUT SPECTR
   Knapp M, 2012, 2012 AUT SUMM INV OU
   Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
   PIVEN J, 1995, AM J PSYCHIAT, V152, P1145
   Suzuki K, 2013, JAMA PSYCHIAT, V70, P49, DOI 10.1001/jamapsychiatry.2013.272
   Volk HE, 2013, JAMA PSYCHIAT, V70, P71, DOI 10.1001/jamapsychiatry.2013.266
   Volk HE, 2011, ENVIRON HEALTH PERSP, V119, P873, DOI 10.1289/ehp.1002835
NR 12
TC 9
Z9 9
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-622X
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JAN
PY 2013
VL 70
IS 1
BP 9
EP 10
PG 2
WC Psychiatry
SC Psychiatry
GA 114GM
UT WOS:000316729100003
PM 23184000
ER

PT J
AU Power, RA
   Kyaga, S
   Uher, R
   MacCabe, JH
   Langstrom, N
   Landen, M
   McGuffin, P
   Lewis, CM
   Lichtenstein, P
   Svensson, AC
AF Power, Robert A.
   Kyaga, Simon
   Uher, Rudolf
   MacCabe, James H.
   Langstrom, Niklas
   Landen, Mikael
   McGuffin, Peter
   Lewis, Cathryn M.
   Lichtenstein, Paul
   Svensson, Anna C.
TI Fecundity of Patients With Schizophrenia, Autism, Bipolar Disorder,
   Depression, Anorexia Nervosa, or Substance Abuse vs Their Unaffected
   Siblings
SO JAMA PSYCHIATRY
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; ADVANCING PATERNAL AGE; MENTAL-DISORDER; MOOD
   DISORDERS; VIOLENT CRIME; FERTILITY; POPULATION; PSYCHOSIS; SWEDEN;
   COHORT
AB Context: It is unknown how genetic variants conferring liability to psychiatric disorders survive in the population despite strong negative selection. However, this is key to understanding their etiology and designing studies to identify risk variants.
   Objectives: To examine the reproductive fitness of patients with schizophrenia and other psychiatric disorders vs their unaffected siblings and to evaluate the level of selection on causal genetic variants.
   Design: We measured the fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse and their unaffected siblings compared with the general population.
   Setting: Population databases in Sweden, including the Multi-Generation Register and the Swedish Hospital Discharge Register.
   Participants: In total, 2.3million individuals among the 1950 to 1970 birth cohort in Sweden.
   Main Outcome Measures: Fertility ratio (FR), reflecting the mean number of children compared with that of the general population, accounting for age, sex, family size, and affected status.
   Results: Except for women with depression, affected patients had significantly fewer children (FR range for those with psychiatric disorder, 0.23-0.93; P < 10(-10)). This reduction was consistently greater among men than women, suggesting that male fitness was particularly sensitive. Although sisters of patients with schizophrenia and bipolar disorder had increased fecundity (FR range, 1.02-1.03; P <.01), this was too small on its own to counterbalance the reduced fitness of affected patients. Brothers of patients with schizophrenia and autism showed reduced fecundity (FR range, 0.94-0.97; P < .001). Siblings of patients with depression and substance abuse had significantly increased fecundity (FR range, 1.01-1.05; P < 10(-10)). In the case of depression, this more than compensated for the lower fecundity of affected individuals.
   Conclusions: Our results suggest that strong selection exists against schizophrenia, autism, and anorexia nervosa and that these variants may be maintained by new mutations or an as-yet unknown mechanism. Bipolar disorder did not seem to be under strong negative selection. Vulnerability to depression, and perhaps substance abuse, may be preserved by balancing selection, suggesting the involvement of common genetic variants in ways that depend on other genes and on environment.
C1 [Power, Robert A.; Uher, Rudolf] Kings Coll London, Inst Psychiat, Social Genet & Dev Ctr, London SE5 8AF, England.
   [MacCabe, James H.; McGuffin, Peter; Lewis, Cathryn M.] Kings Coll London, Dept Psychosis Studies, London SE5 8AF, England.
   [Kyaga, Simon; Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Svensson, Anna C.] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
   [Langstrom, Niklas] Karolinska Inst, Ctr Violence Prevent, Stockholm, Sweden.
   [Svensson, Anna C.] Karolinska Inst, Div Publ Hlth Epidemiol, Stockholm, Sweden.
   [Landen, Mikael] Gothenburg Univ, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden.
RP Power, RA (reprint author), Kings Coll London, Inst Psychiat, Social Genet & Dev Ctr, De Creispigny Pk, London SE5 8AF, England.
EM robert.r.power@kcl.ac.uk
RI Power, Robert/B-3482-2012; McGuffin, Peter/A-1565-2012; Uher,
   Rudolf/A-5477-2008; Lewis, Cathryn/A-5225-2010
OI McGuffin, Peter/0000-0002-9888-2907; Uher, Rudolf/0000-0002-2998-0546;
   Lewis, Cathryn/0000-0002-8249-8476
FU Medical Research Council of the United Kingdom
FX This study was supported by the Medical Research Council of the United
   Kingdom (Mr Power).
CR Allen NB, 2006, PROG NEURO-PSYCHOPH, V30, P815, DOI 10.1016/j.pnpbp.2006.01.007
   [Anonymous], 2006, SWED HOSP DISCH REG
   [Anonymous], 2010, MULTIGENERATION REGI
   [Anonymous], 2011, STATA STAT SOFTW
   Armstrong C, 1997, BRIT MED J, V315, P563
   Bassett AS, 1996, SCHIZOPHR RES, V21, P151, DOI 10.1016/0920-9964(96)00018-7
   BATEMAN AJ, 1948, HEREDITY, V2, P349, DOI 10.1038/hdy.1948.21
   Belsky J, 2009, PSYCHOL BULL, V135, P885, DOI 10.1037/a0017376
   BRINCH M, 1988, ACTA PSYCHIAT SCAND, V77, P611, DOI 10.1111/j.1600-0447.1988.tb05175.x
   Bulik CM, 2006, ARCH GEN PSYCHIAT, V63, P305, DOI 10.1001/archpsyc.63.3.305
   Bundy H, 2011, ACTA PSYCHIAT SCAND, V123, P98, DOI 10.1111/j.1600-0447.2010.01623.x
   Caspi A, 2010, AM J PSYCHIAT, V167, P509, DOI 10.1176/appi.ajp.2010.09101452
   Crespi B, 2008, BEHAV BRAIN SCI, V31, P241, DOI 10.1017/S0140525X08004214
   Crow JF, 2003, SCIENCE, V301, P606, DOI 10.1126/science.1088552
   Crow TJ, 2008, SCHIZOPHR RES, V102, P31, DOI 10.1016/j.schres.2008.03.010
   Dalman C, 2002, SOC PSYCH PSYCH EPID, V37, P527, DOI 10.1007/s00127-002-0582-3
   Daniels JL, 2008, PEDIATRICS, V122, P1162, DOI 10.1542/peds.2008-2595
   Daniels JL, 2012, PEDIATRICS, V121, pe1357
   Durkin MS, 2008, AM J EPIDEMIOL, V168, P1268, DOI 10.1093/aje/kwn250
   Ekholm B, 2005, NORD J PSYCHIAT, V59, P457, DOI 10.1080/08039480500360906
   Fazel S, 2009, JAMA-J AM MED ASSOC, V301, P2016, DOI 10.1001/jama.2009.675
   Fitzmaurice G. M., 2004, APPL LONGITUDINAL AN, P291
   Frans EM, 2008, ARCH GEN PSYCHIAT, V65, P1034, DOI 10.1001/archpsyc.65.9.1034
   Grann M, 2004, BRIT MED J, V328, P1233, DOI 10.1136/bmj.328.7450.1233
   Haukka J, 2003, AM J PSYCHIAT, V160, P460, DOI 10.1176/appi.ajp.160.3.460
   Howard LM, 2002, AM J PSYCHIAT, V159, P991, DOI 10.1176/appi.ajp.159.6.991
   HUXLEY J, 1964, NATURE, V204, P220, DOI 10.1038/204220a0
   Keller MC, 2006, BEHAV BRAIN SCI, V29, P385, DOI 10.1017/S0140525X06009095
   Kim-Cohen J, 2003, ARCH GEN PSYCHIAT, V60, P709, DOI 10.1001/archpsyc.60.7.709
   Kyaga S, 2011, BRIT J PSYCHIAT, V199, P373, DOI 10.1192/bjp.bp.110.085316
   Larsen FW, 1997, EUR CHILD ADOLES PSY, V6, P181
   Laursen TM, 2010, SCHIZOPHR RES, V121, P234, DOI 10.1016/j.schres.2010.05.018
   Lewis CM, 2010, AM J PSYCHIAT, V167, P949, DOI 10.1176/appi.ajp.2010.09091380
   Lichtenstein P, 2009, LANCET, V373, P234, DOI 10.1016/S0140-6736(09)60072-6
   MacCabe JH, 2009, PSYCHOL MED, V39, P1667, DOI 10.1017/S0033291709005431
   Malaspina D, 2001, ARCH GEN PSYCHIAT, V58, P361, DOI 10.1001/archpsyc.58.4.361
   Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
   Ng CH, 1997, AUST NZ J PSYCHIAT, V31, P382, DOI 10.3109/00048679709073848
   Osby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
   Ramrakha S, 2011, J SEX MED, V8, P258
   Rees E, 2011, BIOL PSYCHIAT, V70, P1109, DOI 10.1016/j.biopsych.2011.07.011
   Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026
   Sellgren C, 2011, ACTA PSYCHIAT SCAND, V124, P447, DOI 10.1111/j.1600-0447.2011.01747.x
   Shi J, 2011, MOL PSYCHIATR, V16, P193, DOI 10.1038/mp.2009.124
   Shibre T, 2001, SOC PSYCH PSYCH EPID, V36, P299, DOI 10.1007/s001270170048
   SLATER E, 1971, SOC BIOL, V18, pS60
   Sullivan PF, 2009, MOL PSYCHIATR, V14, P359, DOI 10.1038/mp.2008.125
   Surja AAS, 2007, MED HYPOTHESES, V69, P587, DOI 10.1016/j.mehy.2006.12.055
   Svensson AC, 2007, SCHIZOPHR RES, V91, P238, DOI 10.1016/j.schres.2006.12.002
   Tannsjo T, 1998, BIOETHICS, V12, P236, DOI 10.1111/1467-8519.00110
   Uher R, 2008, MOL PSYCHIATR, V13, P1070, DOI 10.1038/mp.2008.92
   Uher R, 2009, MOL PSYCHIATR, V14, P1072, DOI 10.1038/mp.2009.85
   Visscher PM, 2011, MOL PSYCHIAT
   Vissers LELM, 2010, NAT GENET, V42, P1109, DOI 10.1038/ng.712
   Voight BF, 2006, PLOS BIOL, V4, P659, DOI 10.1371/journal.pbio.0040072
   Voight BF, 2007, PLOS BIOL, V5, P1382, DOI 10.1371/journal.pbio.0050147
   Voight BF, 2006, PLOS BIOL, V4, pe72, DOI DOI 10.1371/JOURNAL.PBIO.0040072
   Weiser M, 2009, ACTA PSYCHIAT SCAND, V119, P466, DOI 10.1111/j.1600-0447.2008.01332.x
   Wicks S, 2010, AM J PSYCHIAT, V167, P1240, DOI 10.1176/appi.ajp.2010.09010114
   Williams KE, 2007, HUM REPROD UPDATE, V13, P607, DOI 10.1093/humupd/dmm019
   Wray NR, 2012, MOL PSYCHIATR, V17, P36, DOI 10.1038/mp.2010.109
   Xu B, 2011, NAT GENET, V43, P864, DOI 10.1038/ng.902
   ZEGER SL, 1988, BIOMETRICS, V44, P1049, DOI 10.2307/2531734
NR 64
TC 30
Z9 30
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-622X
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JAN
PY 2013
VL 70
IS 1
BP 22
EP 30
DI 10.1001/jamapsychiatry.2013.268
PG 9
WC Psychiatry
SC Psychiatry
GA 114GM
UT WOS:000316729100005
PM 23147713
ER

PT J
AU Georgiades, S
   Szatmari, P
   Zwaigenbaum, L
   Bryson, S
   Brian, J
   Roberts, W
   Smith, I
   Vaillancourt, T
   Roncadin, C
   Garon, N
AF Georgiades, Stelios
   Szatmari, Peter
   Zwaigenbaum, Lonnie
   Bryson, Susan
   Brian, Jessica
   Roberts, Wendy
   Smith, Isabel
   Vaillancourt, Tracy
   Roncadin, Caroline
   Garon, Nancy
TI A Prospective Study of Autistic-Like Traits in Unaffected Siblings of
   Probands With Autism Spectrum Disorder
SO JAMA PSYCHIATRY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; FAMILY-HISTORY;
   PERSONALITY-CHARACTERISTICS; GENERAL-POPULATION; CHILDREN; PARENTS;
   HERITABILITY; INDIVIDUALS; PHENOTYPE; TODDLERS
AB Context: The presence of autistic-like traits in relatives of individuals with autism spectrum disorder (ASD) is well recognized, but, to our knowledge, the emergence of these traits early in development has not been studied.
   Objective: To prospectively investigate the emergence of autistic-like traits in unaffected (no ASD diagnosis) infant siblings of probands diagnosed as having ASD.
   Design: Two groups of children unaffected with ASD were assessed prospectively-siblings of probands diagnosed as having ASD (high risk [HR]) and control subjects with no family history of ASD (low risk [LR]). Scores on a measure of autistic-like traits at 12 months of age were used in a cluster analysis of the entire sample.
   Setting: A prospective study of infant siblings of probands with ASD from 3 diagnostic centers in Canada.
   Participants: The study included 170 HR and 90 LR children, none of whom was diagnosed as having ASD at age 3 years.
   Main Outcome Measures: The Autism Observation Scale for Infants was used to measure autistic-like traits and derive clusters at 12 months of age. Clusters were compared on ASD symptoms, cognitive abilities, and social- emotional difficulties at age 3 years.
   Results: Two clusters were identified. Cluster 1 (n= 37; 14.2% of total sample) had significantly higher levels of autistic-like traits compared with cluster 2. Within cluster 1, 33 children came from the siblings (19.4% of HR group) and only 4 came from the control subjects (4.5% of LR group). At age 3 years, children from cluster 1 had more social-communication impairment (effect size > 0.70; P < .001), lower cognitive abilities (effect size=-0.59; P < .005), and more internalizing problems (effect size = 0.55; P=. 01). Compared with control subjects, HR siblings had a relative risk of 4.3 (95% CI, 1.6-11.9) for membership in cluster 1.
   Conclusions: Study findings suggest the emergence of autistic-like traits resembling a broader autism phenotype by 12 months of age in approximately 19% of HR siblings who did not meet ASD diagnostic criteria at age 3 years.
C1 [Georgiades, Stelios; Szatmari, Peter] McMaster Univ, Offord Ctr Child Studies, Hamilton, ON L8S 4K1, Canada.
   [Georgiades, Stelios; Szatmari, Peter] McMaster Univ, McMaster Childrens Hosp, Hamilton, ON L8S 4K1, Canada.
   [Brian, Jessica; Roberts, Wendy] Bloorview Res Inst, Toronto, ON, Canada.
   [Brian, Jessica; Roberts, Wendy] Univ Toronto, Toronto, ON M5S 1A1, Canada.
   [Vaillancourt, Tracy] Univ Ottawa, Ottawa, ON K1N 6N5, Canada.
   [Roncadin, Caroline] Peel Childrens Ctr, Toronto, ON, Canada.
   [Zwaigenbaum, Lonnie] Univ Alberta, Edmonton, AB T6G 2M7, Canada.
   [Bryson, Susan; Smith, Isabel] Dalhousie Univ, IWK Hlth Ctr, Halifax, NS B3H 3J5, Canada.
   [Garon, Nancy] Mt Allison Univ, Sackville, NB, Canada.
RP Szatmari, P (reprint author), McMaster Univ, Offord Ctr Child Studies, Chedoke Site,1280 Main St W,Patterson Bldg, Hamilton, ON L8S 4K1, Canada.
EM szatmar@mcmaster.ca
RI Vaillancourt, Tracy/F-8949-2015
FU Canadian Institutes of Health Research; Autism Speaks; NeuroDevNet;
   McMaster Children's Hospital; Stollery Children's Hospital Foundation
   Chair in Autism; Alberta Innovates-Health Solutions
FX This study was supported by the Canadian Institutes of Health Research,
   Autism Speaks, and NeuroDevNet. Mr Georgiades' work is supported by an
   Autism Research Training fellowship from the Canadian Institutes of
   Health Research. Dr Szatmari's work is supported by McMaster Children's
   Hospital. Dr Zwaigenbaum's work is supported by the Stollery Children's
   Hospital Foundation Chair in Autism and a Health Scholar Award from
   Alberta Innovates-Health Solutions.
CR BAILEY A, 1995, PSYCHOL MED, V25, P63
   Baird G, 2011, BRIT MED J, V343, DOI 10.1136/bmj.d6360
   BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
   Bryson SE, 2008, J AUTISM DEV DISORD, V38, P731, DOI 10.1007/s10803-007-0440-y
   Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2
   Carter A, 2000, MANUAL INFANT TODDLE
   Cassel TD, 2007, J AUTISM DEV DISORD, V37, P122, DOI 10.1007/s10803-006-0337-1
   Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
   Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470
   Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
   Flanagan JE, AM J OCCUP IN PRESS
   Georgiades S, 2011, J AUTISM DEV DISORD, V41, P1321, DOI 10.1007/s10803-010-1158-9
   Glass G.V., 1976, EDUC RES, V5, P3, DOI DOI 10.3102/0013189X005010003
   Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372
   Kim SH, 2012, J CHILD PSYCHOL PSYC, V53, P143, DOI 10.1111/j.1469-7610.2011.02458.x
   LANDA R, 1992, PSYCHOL MED, V22, P245
   Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
   Mullen E, 1995, MULLEN SCALES EARLY
   Murphy M, 2000, PSYCHOL MED, V30, P1411, DOI 10.1017/S0033291799002949
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009
   Ozonoff S, 2010, J AM ACAD CHILD ADOL, V49, pe1
   PIVEN J, 1994, PSYCHOL MED, V24, P783
   Piven J, 2001, AM J MED GENET, V105, P34, DOI 10.1002/1096-8628(20010108)105:1<34::AID-AJMG1052>3.0.CO;2-D
   Piven J, 1997, AM J PSYCHIAT, V154, P185
   Skuse DH, 2005, BRIT J PSYCHIAT, V187, P568, DOI 10.1192/bjp.187.6.568
   Stone WL, 2007, ARCH PEDIAT ADOL MED, V161, P384, DOI 10.1001/archpedi.161.4.384
   Szatmari P, 2000, J CHILD PSYCHOL PSYC, V41, P579, DOI 10.1017/S0021963099005831
   Szatmari P, 2008, AM J MED GENET B, V147B, P3, DOI 10.1002/ajmg.b.30561
   Szatmari P, 2011, ARCH GEN PSYCHIAT, V68, P1091, DOI 10.1001/archgenpsychiatry.2011.99
   Tabachnick B. G., 2007, EXPT DESIGNS USING A
   WOLFF S, 1988, J CHILD PSYCHOL PSYC, V29, P143, DOI 10.1111/j.1469-7610.1988.tb00699.x
   Yirmiya N, 2005, J CHILD PSYCHOL PSYC, V46, P69, DOI 10.1111/j.1469-7610.2004.00334.x
   Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606
   Zwaigenbaum L, 2007, J AUTISM DEV DISORD, V37, P466, DOI 10.1007/s10803-006-0179-x
   Zwaigenbaum L, 2012, J AUTISM DEV DISORD
   Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001
NR 43
TC 19
Z9 19
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-622X
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JAN
PY 2013
VL 70
IS 1
BP 42
EP 48
DI 10.1001/2013.jamapsychiatry.1
PG 7
WC Psychiatry
SC Psychiatry
GA 114GM
UT WOS:000316729100007
PM 22945359
ER

PT J
AU Suzuki, K
   Sugihara, G
   Ouchi, Y
   Nakamura, K
   Futatsubashi, M
   Takebayashi, K
   Yoshihara, Y
   Omata, K
   Matsumoto, K
   Tsuchiya, KJ
   Iwata, Y
   Tsujii, M
   Sugiyama, T
   Mori, N
AF Suzuki, Katsuaki
   Sugihara, Genichi
   Ouchi, Yasuomi
   Nakamura, Kazuhiko
   Futatsubashi, Masami
   Takebayashi, Kiyokazu
   Yoshihara, Yujiro
   Omata, Kei
   Matsumoto, Kaori
   Tsuchiya, Kenji J.
   Iwata, Yasuhide
   Tsujii, Masatsugu
   Sugiyama, Toshirou
   Mori, Norio
TI Microglial Activation in Young Adults With Autism Spectrum Disorder
SO JAMA PSYCHIATRY
LA English
DT Article
ID OBSESSIVE COMPULSIVE SCALE; HIGH-FUNCTIONING AUTISM;
   CENTRAL-NERVOUS-SYSTEM; IN-VIVO; IMMUNE-RESPONSE; BRAIN; CHILDREN;
   CELLS; SERUM; MODEL
AB Context: A growing body of evidence suggests that aberrant immunologic systems underlie the pathophysiologic characteristics of autism spectrum disorder (ASD). However, to our knowledge, no information is available on the patterns of distribution of microglial activation in the brain in ASD.
   Objectives: To identify brain regions associated with excessively activated microglia in the whole brain, and to examine similarities in the pattern of distribution of activated microglia in subjects with ASD and control subjects.
   Design: Case-control study using positron emission tomography and a radiotracer for microglia-[C-11](R)-(1[ 2-chrorophynyl]-N-methyl-N-[1-methylpropyl]-3 isoquinoline carboxamide) ([C-11](R)-PK11195).
   Setting: Subjects recruited from the community.
   Participants: Twenty men with ASD (age range, 18-31 years; mean [SD] IQ, 95.9 [16.7]) and 20 age-and IQ-matched healthy men as controls. Diagnosis of ASD was made in accordance with the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised.
   Main Outcome Measures: Regional brain [11C](R)PK11195 binding potential as a representative measure of microglial activation.
   Results: The [11C](R)-PK11195 binding potential values were significantly higher in multiple brain regions in young adults with ASD compared with those of controls (P <.05, corrected). Brain regions with increased binding potentials included the cerebellum, midbrain, pons, fusiform gyri, and the anterior cingulate and orbitofrontal cortices. The most prominent increase was observed in the cerebellum. The pattern of distribution of [11C](R)PK11195 binding potential values in these brain regions of ASD and control subjects was similar, whereas the magnitude of the [11C](R)-PK11195 binding potential in the ASD group was greater than that of controls in all regions.
   Conclusions: Our results indicate excessive microglial activation in multiple brain regions in young adult subjects with ASD. The similar distribution pattern of regional microglial activity in the ASD and control groups may indicate augmented but not altered microglial activation in the brain in the subjects with ASD.
C1 [Suzuki, Katsuaki; Sugihara, Genichi; Omata, Kei; Matsumoto, Kaori; Tsuchiya, Kenji J.; Mori, Norio] Hamamatsu Univ Sch Med, Res Ctr Child Mental Dev, Hamamatsu, Shizuoka 4313192, Japan.
   [Suzuki, Katsuaki; Ouchi, Yasuomi; Tsuchiya, Kenji J.] Hamamatsu Univ Sch Med, United Grad Sch Child Dev, Hamamatsu, Shizuoka 4313192, Japan.
   [Ouchi, Yasuomi] Hamamatsu Univ Sch Med, Mol Imaging Frontier Res Ctr, Hamamatsu, Shizuoka 4313192, Japan.
   [Nakamura, Kazuhiko; Takebayashi, Kiyokazu; Iwata, Yasuhide; Mori, Norio] Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 4313192, Japan.
   [Sugiyama, Toshirou] Hamamatsu Univ Sch Med, Dept Child & Adolescent Psychiat, Hamamatsu, Shizuoka 4313192, Japan.
   [Ouchi, Yasuomi; Futatsubashi, Masami] Hamamatsu Med Ctr, Positron Med Ctr, Hamamatsu, Shizuoka, Japan.
   [Yoshihara, Yujiro] Koujin Hosp, Nagoya, Aichi, Japan.
   [Tsujii, Masatsugu] Chukyo Univ, Fac Sociol, Toyota, Japan.
RP Mori, N (reprint author), Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan.
EM morin@hama-med.ac.jp
FU Strategic Research Program for Brain Sciences; Ministry of Education,
   Culture, Sports, Science, and Technology, Japan; Research on Brain
   Science Funds from the Ministry of Health, Labour, and Welfare, Japan.
FX This work was supported by the Strategic Research Program for Brain
   Sciences (" Integrated research on neuropsychiatric disorders") and a
   Grant-in- Aid for Scientific Research from the Ministry of Education,
   Culture, Sports, Science, and Technology, Japan, and by the Research on
   Brain Science Funds from the Ministry of Health, Labour, and Welfare,
   Japan.
CR Allen G, 2004, BIOL PSYCHIAT, V56, P269, DOI 10.1016/j.biophsych.2004.06.005
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Ashwood P, 2006, J LEUKOCYTE BIOL, V80, P1, DOI 10.1189/jlb.1205707
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Ashwood P, 2011, J NEUROIMMUNOL, V232, P196, DOI 10.1016/j.jneuroim.2010.10.025
   Avignone E, 2008, J NEUROSCI, V28, P9133, DOI 10.1523/JNEUROSCI.1820-08.2008
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   Banati RB, 2002, GLIA, V40, P206, DOI 10.1002/glia.10144
   Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Braunschweig D, 2008, NEUROTOXICOLOGY, V29, P226, DOI 10.1016/j.neuro.2007.10.010
   Cagnin A, 2001, LANCET, V358, P461, DOI 10.1016/S0140-6736(01)05625-2
   Chan WY, 2007, BRAIN RES REV, V53, P344, DOI 10.1016/j.brainresrev.2006.11.002
   Corbett BA, 2007, MOL PSYCHIATR, V12, P292, DOI 10.1038/sj.mp.4001943
   Croen LA, 2008, BIOL PSYCHIAT, V64, P583, DOI 10.1016/j.biopsych.2008.05.006
   Croonenberghs J, 2002, PSYCHOL MED, V32, P1457, DOI 10.1017/S0033291702006037
   Croonenberghs J, 2002, NEUROPSYCHOBIOLOGY, V45, P1, DOI 10.1159/000048665
   Dalton P, 2003, ANN NEUROL, V53, P533, DOI 10.1002/ana.10557
   First Michael B, 1997, USERS GUIDE STRUCTUR
   Friedman SD, 2006, ARCH GEN PSYCHIAT, V63, P786, DOI 10.1001/archpsyc.63.7.786
   Ginhoux F, 2010, SCIENCE, V330, P841, DOI 10.1126/science.1194637
   GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1012
   GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
   Graeber MB, 2010, SCIENCE, V330, P783, DOI 10.1126/science.1190929
   Gunn RN, 1997, NEUROIMAGE, V6, P279, DOI 10.1006/nimg.1997.0303
   Hanisch UK, 2007, NAT NEUROSCI, V10, P1387, DOI 10.1038/nn1997
   Hashioka Sadayuki, 2009, Central Nervous System Agents in Medicinal Chemistry, V9, P12
   Kato TA, 2011, MINI-REV MED CHEM, V11, P565
   Kennedy DW, 1997, BLOOD, V90, P986
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Kreutzberg GW, 1996, TRENDS NEUROSCI, V19, P312, DOI 10.1016/0166-2236(96)10049-7
   Lammertsma AA, 1996, NEUROIMAGE, V4, P153, DOI 10.1006/nimg.1996.0066
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Man SM, 2007, BRAIN PATHOL, V17, P243, DOI 10.1111/j.1750-3639.2007.00067.x
   Marin-Teva JL, 2004, NEURON, V41, P535, DOI 10.1016/S0896-6273(04)00069-8
   Minshew NJ, 2010, CURR OPIN NEUROL, V23, P124, DOI 10.1097/WCO.0b013e32833782d4
   Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024
   Najjar S, 2011, NEUROLOGIST, V17, P249, DOI 10.1097/NRL.0b013e31822aad04
   Nakai A, 2011, RES DEV DISABIL, V32, P1615, DOI 10.1016/j.ridd.2011.02.012
   Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137
   Neumann H, 2009, BRAIN, V132, P288, DOI 10.1093/brain/awn109
   Odell D, 2005, HUM IMMUNOL, V66, P140, DOI 10.1016/j.humimm.2004.11.002
   ORNITZ EM, 1985, ARCH GEN PSYCHIAT, V42, P1018
   Ouchi Y, 2005, ANN NEUROL, V57, P168, DOI 10.1002/ana.20338
   Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
   Paolicelli RC, 2011, SCIENCE, V333, P1456, DOI 10.1126/science.1202529
   Pierce K, 2001, BIOL PSYCHIAT, V49, P655, DOI 10.1016/S0006-3223(00)01008-8
   Rebenko-Moll NM, 2006, CURR OPIN IMMUNOL, V18, P683, DOI 10.1016/j.col.2006.09.05
   Rezaie P, 1999, MICROSC RES TECHNIQ, V45, P359, DOI 10.1002/(SICI)1097-0029(19990615)45:6<359::AID-JEMT4>3.0.CO;2-D
   RITVO ER, 1986, AM J PSYCHIAT, V143, P862
   Schlegelmilch T, 2011, CURR OPIN NEUROBIOL, V21, P5, DOI 10.1016/j.conb.2010.08.004
   Schuitemaker A, 2007, NEUROIMAGE, V35, P1473, DOI 10.1016/j.neuroimage.2007.02.013
   Schwarz E, 2011, MOL PSYCHIATR, V16, P1213, DOI 10.1038/mp.2010.102
   Singer HS, 2009, J NEUROIMMUNOL, V211, P39, DOI 10.1016/j.jneuroim.2009.03.011
   Stigler KA, 2009, RES AUTISM SPECT DIS, V3, P840, DOI 10.1016/j.rasd.2009.01.007
   Streit WJ, 2005, NEUROL RES, V27, P685, DOI 10.1179/016164105X49463
   Suzuki K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020470
   Suzuki K, 2011, ARCH GEN PSYCHIAT, V68, P306, DOI 10.1001/archgenpsychiatry.2011.4
   Suzuki K, 2010, INT J NEUROPSYCHOPH, V13, P529, DOI 10.1017/S1461145709990952
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110
   Wake H, 2009, J NEUROSCI, V29, P3974, DOI 10.1523/JNEUROSCI.4363-08.2009
   Warren RP, 1996, J NEUROIMMUNOL, V67, P97
   WARREN RP, 1991, CLIN EXP IMMUNOL, V83, P438
   Zimmerman AW, 2005, PEDIATR NEUROL, V33, P195, DOI 10.1016/j.pediatrneurol.2005.03.014
NR 67
TC 35
Z9 36
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-622X
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JAN
PY 2013
VL 70
IS 1
BP 49
EP 58
DI 10.1001/jamapsychiatry.2013.272
PG 10
WC Psychiatry
SC Psychiatry
GA 114GM
UT WOS:000316729100008
PM 23404112
ER

PT J
AU Ecker, C
   Ginestet, C
   Feng, Y
   Johnston, P
   Lombardo, MV
   Lai, MC
   Suckling, J
   Palaniyappan, L
   Daly, E
   Murphy, CM
   Williams, SC
   Bullmore, ET
   Baron-Cohen, S
   Brammer, M
   Murphy, DGM
AF Ecker, Christine
   Ginestet, Cedric
   Feng, Yue
   Johnston, Patrick
   Lombardo, Michael V.
   Lai, Meng-Chuan
   Suckling, John
   Palaniyappan, Lena
   Daly, Eileen
   Murphy, Clodagh M.
   Williams, Steven C.
   Bullmore, Edward T.
   Baron-Cohen, Simon
   Brammer, Michael
   Murphy, Declan G. M.
CA MRC AIMS Consortium
TI Brain Surface Anatomy in Adults With Autism
SO JAMA PSYCHIATRY
LA English
DT Article
ID VOXEL-BASED MORPHOMETRY; HIGH-FUNCTIONING AUTISM; MAGNETIC-RESONANCE
   IMAGES; HUMAN CEREBRAL-CORTEX; CORTICAL THICKNESS; SPECTRUM DISORDER;
   ASPERGER-SYNDROME; CHILDHOOD AUTISM; PROGENITOR CELLS; REVISED VERSION
AB Context: Neuroimaging studies of brain anatomy in autism spectrum disorder (ASD) have mostly been based on measures of cortical volume (CV). However, CV is a product of 2 distinct parameters, cortical thickness (CT) and surface area (SA), that in turn have distinct genetic and developmental origins.
   Objective: To investigate regional differences in CV, SA, and CT as well as their relationship in a large and well-characterized sample of men with ASD and matched controls.
   Design: Multicenter case-control design using quantitative magnetic resonance imaging.
   Setting: Medical Research Council UK Autism Imaging Multicentre Study.
   Participants: A total of 168 men, 84 diagnosed as having ASD and 84 controls who did not differ significantly in mean (SD) age (26 [7] years vs 28 [6] years, respectively) or full-scale IQ (110 [14] vs 114 [12], respectively).
   Main Outcome Measures: Between-group differences in CV, SA, and CT investigated using a spatially unbiased vertex-based approach; the degree of spatial over-lap between the differences in CT and SA; and their relative contribution to differences in regional CV.
   Results: Individuals with ASD differed from controls in all 3 parameters. These mainly consisted of significantly increased CT within frontal lobe regions and reduced SA in the orbitofrontal cortex and posterior cingulum. These differences in CT and SA were paralleled by commensurate differences in CV. The spatially distributed patterns for CT and SA were largely nonoverlapping and shared only about 3% of all significantly different locations on the cerebral surface.
   Conclusions: Individuals with ASD have significant differences in CV, but these may be underpinned by (separable) variations in its 2 components, CT and SA. This is of importance because both measures result from distinct developmental pathways that are likely modulated by different neurobiological mechanisms. This finding may provide novel targets for future studies into the etiology of the condition and a new way to fractionate the disorder.
C1 [Ecker, Christine; Ginestet, Cedric; Feng, Yue; Johnston, Patrick; Daly, Eileen; Murphy, Clodagh M.; Williams, Steven C.; Brammer, Michael; Murphy, Declan G. M.] Kings Coll London, Dept Forens & Neurodev Sci, Inst Psychiat, London SE5 8AF, England.
   [Lombardo, Michael V.; Lai, Meng-Chuan; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Suckling, John; Williams, Steven C.] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge, England.
   [Palaniyappan, Lena] Univ Nottingham, Div Psychiat, Nottingham NG7 2RD, England.
RP Ecker, C (reprint author), Kings Coll London, Dept Forens & Neurodev Sci, Inst Psychiat, PO50,De Crespigny Pk, London SE5 8AF, England.
EM christine.ecker@kcl.ac.uk
RI Bullmore, Edward/C-1706-2012; Williams, Steve/D-6979-2011; Ecker,
   Christine/E-5194-2010; Bolton, Patrick/E-8501-2010; Bailey,
   Anthony/J-2860-2014
OI Bullmore, Edward/0000-0002-8955-8283; Bolton,
   Patrick/0000-0002-5270-6262; Bailey, Anthony/0000-0003-4257-972X
FU Medical Research Council; AIMS Consortium [G0400061]; NIHR; South London
   & Maudsley NHS Foundation Trust
FX The MRC AIMS Consortium is a collaboration of autism research centers in
   the United Kingdom including the Institute of Psychiatry, King's College
   London; the Autism Research Centre, University of Cambridge; and the
   Autism Research Group, University of Oxford. It is funded by the Medical
   Research Council and headed by the Department of Forensic and
   Neurodevelopmental Sciences, Institute of Psychiatry. This work was
   supported by the AIMS Consortium through grant G0400061 from the Medical
   Research Council and by the NIHR Biomedical Research Centre for Mental
   Health at King's College London, Institute of Psychiatry, and South
   London & Maudsley NHS Foundation Trust. Scanning took place in 3 centers
   (London, Oxford, and Cambridge; local principal investigators were Drs
   Bailey, Baron-Cohen, Bullmore, and D.G.M. Murphy).
CR Abell F, 1999, NEUROREPORT, V10, P1647, DOI 10.1097/00001756-199906030-00005
   Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   ARMSTRONG E, 1995, CEREB CORTEX, V5, P56, DOI 10.1093/cercor/5.1.56
   Avino TA, 2010, BRAIN RES, V1360, P138, DOI 10.1016/j.brainres.2010.08.091
   Aylward EH, 2002, NEUROLOGY, V59, P175
   Baala L, 2007, NAT GENET, V39, P454, DOI 10.1038/ng1993
   Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
   Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006
   Bedogni F, 2010, GENE EXPR PATTERNS, V10, P9, DOI 10.1016/j.gep.2009.11.005
   Blakemore SJ, 2001, NAT REV NEUROSCI, V2, P561
   Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016
   Bolton PF, 1997, LANCET, V349, P392, DOI 10.1016/S0140-6736(97)80012-8
   Buckner RL, 2004, NEUROIMAGE, V23, P724, DOI 10.1016/j.neuroimage.2004.06.018
   Carper RA, 2005, BIOL PSYCHIAT, V57, P126, DOI 10.1016/j.biopsych.2004.11.005
   Casanova MF, 2002, J CHILD NEUROL, V17, P515, DOI 10.1177/088307380201700708
   Chung MK, 2003, NEUROIMAGE, V18, P198, DOI 10.1016/S1053-8119(02)00017-4
   COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102
   Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
   Dale AM, 1999, NEUROIMAGE, V9, P179, DOI 10.1006/nimg.1998.0395
   Deoni SCL, 2008, NEUROIMAGE, V40, P662, DOI 10.1016/j.neuroimage.2007.11.052
   Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010
   Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251
   Filimonoff I N, 1966, J Hirnforsch, V8, P503
   Fischl B, 2000, P NATL ACAD SCI USA, V97, P11050, DOI 10.1073/pnas.200033797
   Fischl B, 2004, CEREB CORTEX, V14, P11, DOI 10.1093/cercor/bhg087
   Fischl B, 2004, NEUROIMAGE, V23, pS69, DOI 10.1016/j.neuroimage.2004.07.016
   Fischl B, 1999, NEUROIMAGE, V9, P195, DOI 10.1006/nimg.1998.0396
   Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
   Gallagher HL, 2003, TRENDS COGN SCI, V7, P77, DOI 10.1016/S1364-6613(02)00025-6
   GILLBERG C, 1993, J INTELL DISABIL RES, V37, P343
   GLASER T, 1994, NAT GENET, V7, P463, DOI 10.1038/ng0894-463
   Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
   Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290
   Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39
   Hietanen JK, 1996, BEHAV BRAIN RES, V76, P155, DOI 10.1016/0166-4328(95)00193-X
   Hutton C, 2009, NEUROIMAGE, V48, P371, DOI 10.1016/j.neuroimage.2009.06.043
   Hyde KL, 2010, HUM BRAIN MAPP, V31, P556, DOI 10.1002/hbm.20887
   Jovicich J, 2006, NEUROIMAGE, V30, P436, DOI 10.1016/j.neuroimage.2005.09.046
   Joyner AH, 2009, P NATL ACAD SCI USA, V106, P15483, DOI 10.1073/pnas.0901866106
   Kwon H, 2004, DEV MED CHILD NEUROL, V46, P760, DOI 10.1017/S0012162204001306
   Levene H., 1960, CONTRIBUTIONS PROBAB, P278
   Loat CS, 2008, GENES BRAIN BEHAV, V7, P754, DOI 10.1111/j.1601-183X.2008.00414.x
   Lombardo MV, 2010, BRAIN, V133, P611, DOI 10.1093/brain/awp306
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Mak-Fan KM, 2012, J AUTISM DEV DISORD, V42, P419, DOI 10.1007/s10803-011-1261-6
   McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150
   McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332
   Miyata T, 2004, DEVELOPMENT, V131, P3133, DOI 10.1242/dev.01173
   Mountcastle VB, 1997, BRAIN, V120, P701, DOI 10.1093/brain/120.4.701
   Murphy DGM, 2002, ARCH GEN PSYCHIAT, V59, P885, DOI 10.1001/archpsyc.59.10.885
   Noctor SC, 2004, NAT NEUROSCI, V7, P136, DOI 10.1038/nn1172
   Pakkenberg B, 1997, J COMP NEUROL, V384, P312, DOI 10.1002/(SICI)1096-9861(19970728)384:2<312::AID-CNE10>3.0.CO;2-K
   Palaniyappan L, 2011, SCHIZOPHR RES, V129, P163, DOI 10.1016/j.schres.2011.03.020
   Panizzon MS, 2009, CEREB CORTEX, V19, P2728, DOI 10.1093/cercor/bhp026
   Pelphrey KA, 2008, DEV PSYCHOPATHOL, V20, P1081, DOI 10.1017/S0954579408000515
   Pontious A, 2008, DEV NEUROSCI-BASEL, V30, P24, DOI 10.1159/000109848
   Rakic P, 2007, BRAIN RES REV, V55, P204, DOI 10.1016/j.brainresrev.2007.02.010
   RAKIC P, 1995, TRENDS NEUROSCI, V18, P383, DOI 10.1016/0166-2236(95)93934-P
   RAKIC P, 1988, PROG BRAIN RES, V73, P15
   Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198
   Rimol LM, 2010, P NATL ACAD SCI USA, V107, P384, DOI 10.1073/pnas.0908454107
   Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56
   Saitoh O, 2001, BRAIN, V124, P1317, DOI 10.1093/brain/124.7.1317
   Sanides F, 1969, J Hirnforsch, V11, P79
   Scheel C, 2011, NEUROIMAGE, V58, P391, DOI 10.1016/j.neuroimage.2011.06.040
   Schmitz N, 2007, NEUROSCI LETT, V412, P12, DOI 10.1016/j.neulet.2006.07.077
   Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010
   Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2
   Segonne F, 2004, NEUROIMAGE, V22, P1060, DOI 10.1016/j.neuroimage.2004.03.032
   Suckling J, 2012, HUM BRAIN MAPP, V33, P373, DOI 10.1002/hbm.21210
   Suckling J, 2010, HUM BRAIN MAPP, V31, P1183, DOI 10.1002/hbm.20927
   Sultana R, 2002, GENOMICS, V80, P129, DOI 10.1006/geno.2002.6810
   Thompson PM, 2005, J NEUROSCI, V25, P4146, DOI 10.1523/JNEUROSCI.0165-05.2005
   Toal F, 2005, BRIT J PSYCHIAT, V187, P395, DOI 10.1192/bjp.187.5.395
   Voets NL, 2008, NEUROIMAGE, V43, P665, DOI 10.1016/j.neuroimage.2008.08.013
   Waiter GD, 2004, NEUROIMAGE, V22, P619, DOI 10.1016/j.neuroimage.2004.02.029
   Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
   Wechsler D, 1999, WECHSLER ABBREVIATED
   White T, 2011, DEV PSYCHOPATHOL, V23, P339, DOI 10.1017/S0954579410000842
   Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0
   Worsley KJ, 1999, HUM BRAIN MAPP, V8, P98, DOI 10.1002/(SICI)1097-0193(1999)8:2/3<98::AID-HBM5>3.0.CO;2-F
   ZILBOVICIUS M, 1995, AM J PSYCHIAT, V152, P248
NR 86
TC 25
Z9 26
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-622X
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JAN
PY 2013
VL 70
IS 1
BP 59
EP 70
DI 10.1001/jamapsychiatry.2013.265
PG 12
WC Psychiatry
SC Psychiatry
GA 114GM
UT WOS:000316729100009
PM 23404046
ER

PT J
AU Volk, HE
   Lurmann, F
   Penfold, B
   Hertz-Picciotto, I
   McConnell, R
AF Volk, Heather E.
   Lurmann, Fred
   Penfold, Bryan
   Hertz-Picciotto, Irva
   McConnell, Rob
TI Traffic-Related Air Pollution, Particulate Matter, and Autism
SO JAMA PSYCHIATRY
LA English
DT Article
ID ULTRAFINE PARTICLES; SPECTRUM DISORDERS; PRENATAL EXPOSURE; MAJOR
   HIGHWAY; CHILDREN; BRAIN; NANOPARTICLES; INFLAMMATION; ENHANCEMENT;
   POLLUTANTS
AB Context: Autism is a heterogeneous disorder with genetic and environmental factors likely contributing to its origins. Examination of hazardous pollutants has suggested the importance of air toxics in the etiology of autism, yet little research has examined its association with local levels of air pollution using residence-specific exposure assignments.
   Objective: To examine the relationship between traffic-related air pollution, air quality, and autism.
   Design: This population-based case-control study includes data obtained from children with autism and control children with typical development who were enrolled in the Childhood Autism Risks from Genetics and the Environment study in California. The mother's address from the birth certificate and addresses reported from a residential history questionnaire were used to estimate exposure for each trimester of pregnancy and first year of life. Traffic-related air pollution was assigned to each location using a line-source air-quality dispersion model. Regional air pollutant measures were based on the Environmental Protection Agency's Air Quality System data. Logistic regression models compared estimated and measured pollutant levels for children with autism and for control children with typical development.
   Setting: Case-control study from California. Participants: A total of 279 children with autism and a total of 245 control children with typical development.
   Main Outcome Measures: Crude and multivariable adjusted odds ratios (AORs) for autism.
   Results: Children with autism were more likely to live at residences that had the highest quartile of exposure to traffic-related air pollution, during gestation (AOR, 1.98 [95% CI, 1.20-3.31]) and during the first year of life (AOR, 3.10 [95% CI, 1.76-5.57]), compared with control children. Regional exposure measures of nitrogen dioxide and particulate matter less than 2.5 and 10 mu m in diameter (PM2.5 and PM10) were also associated with autism during gestation (exposure to nitrogen dioxide: AOR, 1.81 [95% CI, 1.37-3.09]; exposure to PM2.5: AOR, 2.08 [95% CI, 1.93-2.25]; exposure to PM10: AOR, 2.17 [95% CI, 1.49-3.16) and during the first year of life (exposure to nitrogen dioxide: AOR, 2.06 [95% CI, 1.37-3.09]; exposure to PM2.5: AOR, 2.12 [95% CI, 1.45-3.10]; exposure to PM10: AOR, 2.14 [95% CI, 1.46-3.12]). All regional pollutant estimates were scaled to twice the standard deviation of the distribution for all pregnancy estimates.
   Conclusions: Exposure to traffic-related air pollution, nitrogen dioxide, PM2.5, and PM10 during pregnancy and during the first year of life was associated with autism. Further epidemiological and toxicological examinations of likely biological pathways will help determine whether these associations are causal.
C1 [Volk, Heather E.; McConnell, Rob] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA.
   [Volk, Heather E.] Univ So Calif, Dept Pediat, Los Angeles, CA 90089 USA.
   [Volk, Heather E.; McConnell, Rob] Univ So Calif, Keck Sch Med, Los Angeles, CA 90089 USA.
   [Volk, Heather E.] Univ So Calif, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA.
   [Volk, Heather E.] Univ So Calif, Childrens Hosp Los Angeles, Los Angeles, CA 90089 USA.
   [Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
   [Lurmann, Fred; Penfold, Bryan] Sonoma Technol Inc, Petaluma, CA USA.
RP Volk, HE (reprint author), Univ So Calif, Dept Prevent Med, 2001 N Soto St,MC 9237, Los Angeles, CA 90089 USA.
EM hvolk@usc.edu
FU National Institute of Environmental Health Sciences [ES019002, ES013578,
   ES007048, ES11269, ES015359]; EPA [Star-R-823392, Star-R-833292]; MIND
   Institute's matching funds; pilot grant program
FX This work was supported by National Institute of Environmental Health
   Sciences grants ES019002, ES013578, ES007048, ES11269, ES015359, EPA
   Star-R-823392, and EPA Star-R-833292 and by the MIND Institute's
   matching funds and pilot grant program.
CR Alcorn SH, 2003, STI952302453FR3
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4th
   [Anonymous], 2009, MMWR SURVEILL SUMM, V14, P1
   Ashwood P, 2008, J NEUROIMMUNOL, V204, P149, DOI 10.1016/j.jneuroim.2008.07.006
   Banks WA, 2002, NEUROIMMUNOMODULAT, V10, P319, DOI 10.1159/000071472
   BENSON PE, 1992, ATMOS ENVIRON B-URB, V26, P379, DOI 10.1016/0957-1272(92)90013-I
   Block ML, 2009, TRENDS NEUROSCI, V32, P506, DOI 10.1016/j.tins.2009.05.009
   Brown LA, 2007, NEUROTOXICOLOGY, V28, P965, DOI 10.1016/j.neuro.2007.05.005
   California Department of Transportation, 2005, CAL MOT VEH STOCK TR
   Campbell A, 2009, J NANOSCI NANOTECHNO, V9, P5099, DOI [10.1166/jnn.2009.GR07, 10.1166/jnn2009.GR07]
   Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180
   Castro-Giner F, 2009, ENVIRON HEALTH PERSP, V117, P1919, DOI 10.1289/ehp.0900589
   Currie J, 2009, J HEALTH ECON, V28, P688, DOI 10.1016/j.jhealeco.2009.02.001
   D'Mello C, 2009, J NEUROSCI, V29, P2089, DOI 10.1523/JNEUROSCI.3567-08.2009
   Enstrom A, 2009, BRAIN BEHAV IMMUN, V23, P389, DOI 10.1016/j.bbi.2008.12.005
   Geiser M, 2005, ENVIRON HEALTH PERSP, V113, P1555, DOI 10.1289/ehp.8006
   Gilliland FD, 2004, LANCET, V363, P119, DOI 10.1016/S0140-6736(03)15262-2
   Hansen CA, 2008, ENVIRON HEALTH PERSP, V116, P362, DOI 10.1289/ehp.10720
   Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483
   Hougaard KS, 2008, PART FIBRE TOXICOL, V5, DOI 10.1186/1743-8977-5-3
   James SJ, 2009, FASEB J, V23, P2374, DOI 10.1096/fj.08-128926
   Kalkbrenner AE, 2010, EPIDEMIOLOGY, V21, P631, DOI 10.1097/EDE.0b013e3181e65d76
   Kunzli N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009096
   Le Couteur A., 2003, AUTISM DIAGNOSTIC IN
   Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934
   Li XH, 2009, J NEUROIMMUNOL, V207, P111, DOI 10.1016/j.jneuroim.2008.12.002
   Lord C, 2003, AUTISM DIAGNOSTIC OB
   Mullen E, 1995, MULLEN SCALES EARLY
   Nguyen MD, 2002, NAT REV NEUROSCI, V3, P216, DOI 10.1038/nrn752
   Ntziachristos L, 2007, ENVIRON SCI TECHNOL, V41, P2223, DOI 10.1021/es062590s
   Oberdorster G, 2009, J NANOSCI NANOTECHNO, V9, P4996, DOI 10.1166/jnn.2009.GR02
   Perera FP, 2006, ENVIRON HEALTH PERSP, V114, P1287, DOI 10.1289/ehp.9084
   Perera FP, 2009, PEDIATRICS, V124, pE195, DOI 10.1542/peds.2008-3506
   Rothen-Rutishauser B, 2008, ALTEX-ALTERN TIEREXP, V25, P191
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Volk HE, 2011, ENVIRON HEALTH PERSP, V119, P873, DOI 10.1289/ehp.1002835
   Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120
   Zhu YF, 2002, J AIR WASTE MANAGE, V52, P1032
   Zhu YF, 2002, ATMOS ENVIRON, V36, P4323, DOI 10.1016/S1352-2310(02)00354-0
NR 40
TC 46
Z9 47
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-622X
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JAN
PY 2013
VL 70
IS 1
BP 71
EP 77
DI 10.1001/jamapsychiatry.2013.266
PG 7
WC Psychiatry
SC Psychiatry
GA 114GM
UT WOS:000316729100010
PM 23404082
ER

PT J
AU Kamio, Y
   Moriwaki, A
   Inokuchi, E
AF Kamio, Yoko
   Moriwaki, Aiko
   Inokuchi, Eiko
TI Neuropsychiatric comorbidities in autism spectrum disorders without
   intellectual disability
SO NEUROLOGY ASIA
LA English
DT Article
ID ASPERGER-SYNDROME; PREVALENCE; CHILDREN
AB Epilepsy and autism spectrum disorder tend to co-occur in the population with intellectual disability. However, in the autistic population without intellectual disability, the prevalence of epilepsy is also much greater than in the general population. The special health needs in children having autism spectrum disorder without intellectual disability, namely those with high-functioning autism spectrum disorder have become recognized in recent years, yet comorbid neuropsychiatric symptoms such as anxiety, attention-deficit/hyperactivity disorder, and epilepsy still sometimes remain undiagnosed and untreated. Heightened awareness of such comorbidities will help these children to access appropriate treatment. Whether the epilepsy associated with high-functioning autism spectrum disorder is the same or different from that associated with intellectual disability, and whether the autistic profile associated with epilepsy in high-functioning autism spectrum disorder is the same or different from that without epilepsy, should be answered by future studies.
C1 [Kamio, Yoko; Moriwaki, Aiko; Inokuchi, Eiko] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Tokyo, Japan.
RP Kamio, Y (reprint author), Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Child & Adolescent Mental Hlth, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878553, Japan.
EM kamio@ncnp.go.jp
FU Japanese Ministry of Health, Labor, and Welfare [H19-KOKORO-006,
   H20-KOKORO-004]
FX This work was supported by grants [H19-KOKORO-006 and H20-KOKORO-004]
   from the Japanese Ministry of Health, Labor, and Welfare.
CR Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030
   Cederlund M, 2004, DEV MED CHILD NEUROL, V46, P652
   Kamio Y, 2011, ANN REPORT RES SUPPO
   Kamio Y, 2013, ACTA PSYCHIAT SCAND, V128, P45, DOI 10.1111/acps.12034
   Kamio Y, 2013, AUTISM, V17, P16
   Kielinen M, 2004, AUTISM, V8, P49, DOI 10.1177/1362361304040638
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Kurita H, 1997, PSYCHIAT CLIN NEUROS, V51, P67, DOI 10.1111/j.1440-1819.1997.tb02909.x
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Williams E, 2008, DEV MED CHILD NEUROL, V50, P672, DOI 10.1111/j.1469-8749.2008.03042.x
NR 10
TC 0
Z9 0
PU ASEAN NEUROLOGICAL ASSOC
PI KUALA LUMPUR
PA UNIV MALAYA MEDICAL CENTRE, NEUROLOGY LABORATORY, KUALA LUMPUR, 59100,
   MALAYSIA
SN 1823-6138
J9 NEUROL ASIA
JI Neurol. Asia
PY 2013
VL 18
SU 1
BP 43
EP 45
PG 3
WC Clinical Neurology
SC Neurosciences & Neurology
GA 115BQ
UT WOS:000316787700013
ER

PT J
AU Tanidir, C
   Uneri, OS
   Gumus, S
   Erkiran, M
AF Tanidir, Canan
   Uneri, Ozden Sukran
   Gumus, Sevda
   Erkiran, Murat
TI Asperger Syndrome Disorder Diagnosed in Adulthood: A Case Report
SO NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
LA English
DT Article
DE Asperger's disorder; adulthood; diagnosis; depression
ID AUTISM; INDIVIDUALS; COMORBIDITY
AB Asperger's disorder (AD) is a pervasive developmental disorder characterized by social impairment, restricted interests and repetitive behaviors. It is seldom that individuals with AD are referred to a psychiatry clinic only for their social and communication deficits. Quite often, the main reason for referral is the presence of other disabling symptoms, such as physical aggression and depression. Although diagnosed mainly in children, AD is increasingly being diagnosed for the first time in adulthood. Here, we present a 24-year-old patient with recurrent depression who was diagnosed as having AD for the first time in adulthood. This case is important to show the difficulty of diagnosing AD for the first time in adulthood and to show how a proper and effective treatment may be delayed if the underlying diagnosis of AD is missed for years. We wanted to emphasize the importance of developmental history and the usefulness of liaison with child and adolescent psychiatry in similar cases when the diagnosis is not clear. (Archives of Neuropsychiatry 2013; 50: 78-81)
C1 [Tanidir, Canan; Uneri, Ozden Sukran] Bakirkoy State Hosp Mental Hlth & Neurol Disorder, Child & Adolescent Psychiat Clin, Istanbul, Turkey.
   [Gumus, Sevda; Erkiran, Murat] Bakirkoy State Hosp Mental Hlth & Neurol Disorder, Istanbul, Turkey.
RP Tanidir, C (reprint author), Bakirkoy State Hosp Mental Hlth & Neurol Disorder, Child & Adolescent Psychiat Clin, Istanbul, Turkey.
EM canantanidir@yahoo.com
CR Abell F, 2005, AUTISM, V9, P515, DOI 10.1177/1362361305057857
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002
   Cederlund M, 2004, DEV MED CHILD NEUROL, V46, P652
   Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279
   Ghaziuddin M., 2002, FOCUS AUTISM OTHER D, V17, P138, DOI DOI 10.1177/10883576020170030301
   Gillberg C, 2002, GUIDE ASPERGER SYNDR
   Hedley D, 2006, AUTISM, V10, P139, DOI 10.1177/1362361306062020
   Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35
   Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
   Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025
   Lugnegard T, 2011, COMPR PSYCHIAT
   Mukaddes NM, 2010, WORLD J BIOL PSYCHIA, V11, P486, DOI [10.1080/15622970902789130, 10.3109/15622970902789130]
   Mukaddes NM, 2010, WORLD J BIOL PSYCHIA, V11, P964, DOI 10.3109/15622975.2010.507785
   Raja M, 2001, GEN HOSP PSYCHIAT, V23, P285, DOI 10.1016/S0163-8343(01)00155-4
   Roy M, 2009, DTSCH ARZTEBL INT, V106, P59, DOI 10.3238/arztebl.2009.0059
   Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
   World Health Organization, 1994, INT CLASS DIS
NR 19
TC 0
Z9 0
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI CAD 22-2, FINDIKZADE, ISTANBUL 34093, TURKEY
SN 1300-0667
J9 NOROPSIKIYATRI ARS
JI Noropsikiyatri Ars.
PY 2013
VL 50
IS 1
BP 78
EP 81
DI 10.4274/Npa.y6270
PG 4
WC Clinical Neurology
SC Neurosciences & Neurology
GA 113GY
UT WOS:000316655800015
ER

PT J
AU Jones, EJH
   Webb, SJ
   Estes, A
   Dawson, G
AF Jones, E. J. H.
   Webb, S. J.
   Estes, A.
   Dawson, G.
TI Rule Learning in Autism: The Role of Reward Type and Social Context
SO DEVELOPMENTAL NEUROPSYCHOLOGY
LA English
DT Article
ID SPECTRUM DISORDERS; EXECUTIVE FUNCTION; YOUNG-CHILDREN; DEVELOPMENTAL
   DELAY; JOINT ATTENTION; FRONTAL-CORTEX; MEMORY; COMMUNICATION;
   PRESCHOOLERS; IMPAIRMENT
AB Learning abstract rules is central to social and cognitive development. Across two experiments, we used Delayed Non-Matching to Sample tasks to characterize the longitudinal development and nature of rule-learning impairments in children with Autism Spectrum Disorder (ASD). Results showed that children with ASD consistently experienced more difficulty learning an abstract rule from a discrete physical reward than children with DD. Rule learning was facilitated by the provision of more concrete reinforcement, suggesting an underlying difficulty in forming conceptual connections. Learning abstract rules about social stimuli remained challenging through late childhood, indicating the importance of testing executive functions in both social and non-social contexts.
C1 [Jones, E. J. H.; Webb, S. J.] Seattle Childrens Hosp, Ctr Child Hlth Behav & Dev, Seattle, WA USA.
   [Webb, S. J.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   [Webb, S. J.] Ctr Human Dev & Disabil, Seattle, WA USA.
   [Webb, S. J.; Estes, A.; Dawson, G.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
   [Estes, A.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
   [Dawson, G.] Autism Speaks, New York, NY USA.
   [Dawson, G.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
RP Webb, SJ (reprint author), Univ Washington, Box 357920 CHDD, Seattle, WA 98195 USA.
EM sjwebb@u.washington.edu
FU NICHD [P01HD34565, P50HD055782]; Autism Speaks Postdoctoral Fellowship
FX Funding was provided by the NICHD sponsored Collaborative Programs of
   Excellence in Autism/CPEA (Dawson, P01HD34565); NICHD sponsored UW
   Autism Center of Excellence/ACE (Webb, Estes; P50HD055782); and Autism
   Speaks Postdoctoral Fellowship (Jones). Additional support was provided
   by collaborators, staff, and students associated with the UW, CPEA, and
   ACE.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   GEWIRTZ JL, 1992, AM PSYCHOL, V47, P1411, DOI 10.1037//0003-066X.47.11.1411
   Barbaro J, 2007, J AUTISM DEV DISORD, V37, P1235, DOI 10.1007/s10803-006-0267-y
   Biro S, 2001, DEV PSYCHOPATHOL, V13, P97, DOI 10.1017/S0954579401001079
   Blair RJR, 2002, NEUROPSYCHOLOGIA, V40, P108, DOI 10.1016/S0028-3932(01)00069-0
   Bolling DZ, 2011, DEV COGN NEUROS-NETH, V1, P280, DOI 10.1016/j.dcn.2011.02.002
   Carpenter PA, 2000, CURR OPIN NEUROBIOL, V10, P195, DOI 10.1016/S0959-4388(00)00074-X
   Carper RA, 2005, BIOL PSYCHIAT, V57, P126, DOI 10.1016/j.biopsych.2004.11.005
   Crone EA, 2006, J NEUROSCI, V26, P11239, DOI 10.1523/JNEUROSCI.2165-06.2006
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   Dawson G, 1998, CHILD DEV, V69, P1276, DOI 10.2307/1132265
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433
   Dawson G, 2002, CHILD DEV, V73, P345, DOI 10.1111/1467-8624.00411
   Dawson G., 1990, DEV PSYCHOPATHOL, V2, P151, DOI 10.1017/S0954579400000675
   DIAMOND A, 1994, BEHAV NEUROSCI, V108, P659, DOI 10.1037//0735-7044.108.4.659
   Diamond A, 2006, TRENDS COGN SCI, V10, P212, DOI 10.1016/j.tics.2006.03.003
   Diamond A, 1999, DEV PSYCHOL, V35, P1507, DOI 10.1037/0012-1649.35.6.1507
   Diamond A., 2002, PRINCIPLES FRONTAL L, P466, DOI [10.1093/acprof:oso/9780195134971.003.0029, DOI 10.1093/ACPROF:OSO/9780195134971.003.0029]
   Dichter GS, 2007, NEUROIMAGE, V35, P1219, DOI 10.1016/j.neuroimage.2006.12.038
   Edgin JO, 2005, J AUTISM DEV DISORD, V35, P729, DOI 10.1007/s10803-005-0020-y
   Elliott C. D., 1990, DIFFERENTIAL ABILITY
   FERRARA C, 1980, J AUTISM DEV DISORD, V10, P51, DOI 10.1007/BF02408432
   Flippin M, 2010, AM J SPEECH-LANG PAT, V19, P178, DOI 10.1044/1058-0360(2010/09-0022)
   Gergely G., 2010, EMBODIED SELF DIMENS, P141
   Griffith EM, 1999, CHILD DEV, V70, P817, DOI 10.1111/1467-8624.00059
   Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001
   Lagattuta KH, 2011, DEVELOPMENTAL SCI, V14, P481, DOI 10.1111/j.1467-7687.2010.00994.x
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Loveland KA, 2008, NEUROPSYCHOLOGIA, V46, P49, DOI 10.1016/j.neuropsychologia.2007.08.017
   Marcus GF, 2007, PSYCHOL SCI, V18, P387, DOI 10.1111/j.1467-9280.2007.01910.x
   MARTIN RC, 1980, J EXP PSYCHOL GEN, V109, P320, DOI 10.1037//0096-3445.109.3.320
   MCEVOY RE, 1993, J CHILD PSYCHOL PSYC, V34, P563, DOI 10.1111/j.1469-7610.1993.tb01036.x
   Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
   Mullen E., 1997, MULLEN SCALES EARLY
   Munson J, 2008, J INT NEUROPSYCH SOC, V14, P956, DOI 10.1017/S1355617708081393
   Pellicano E, 2010, CHILD DEV, V81, P1400, DOI 10.1111/j.1467-8624.2010.01481.x
   Reed P, 2013, AUTISM, V17, P162, DOI 10.1177/1362361311409599
   Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122
   Sigman M, 2005, J AUTISM DEV DISORD, V35, P15, DOI 10.1007/s10803-004-1027-5
   SIGMAN MD, 1992, CHILD DEV, V63, P796, DOI 10.1111/j.1467-8624.1992.tb01662.x
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Thompson C, 1997, COGNITIVE DEV, V12, P199, DOI 10.1016/S0885-2014(97)90013-7
   Triesch J, 2006, DEVELOPMENTAL SCI, V9, P125, DOI 10.1111/j.1467-7687.2006.00470.x
   WESTON DR, 1980, DEV PSYCHOL, V16, P417, DOI 10.1037/0012-1649.16.5.417
NR 46
TC 7
Z9 7
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 8756-5641
J9 DEV NEUROPSYCHOL
JI Dev. Neuropsychol.
PD JAN 1
PY 2013
VL 38
IS 1
BP 58
EP 77
DI 10.1080/87565641.2012.727049
PG 20
WC Psychology, Developmental; Psychology; Psychology, Experimental
SC Psychology
GA 104HX
UT WOS:000315984000004
PM 23311315
ER

PT J
AU Gan, SM
   Tung, LC
   Yeh, CY
   Wang, CH
AF Gan, Shu-Mei
   Tung, Li-Chen
   Yeh, Chun-Yu
   Wang, Chun-Hou
TI ICF-CY based assessment tool for children with autism
SO DISABILITY AND REHABILITATION
LA English
DT Article
DE Autism; children; ICF-CY; international classification of functioning;
   disability and health - children and youth
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDER; SOCIAL SUPPORT;
   INTERNATIONAL CLASSIFICATION; MENTAL-HEALTH; YOUNG-CHILDREN; FOLLOW-UP;
   CORE SET; MOTHERS; DISABILITY
AB Purpose: The objectives of this study was to develop an International Classification of Functioning, Disability and Health-Children and Youth (ICF-CY) based questionnaire for children with autism, investigate the inter-rater reliability of the questionnaire and assess functional performance in children with autism. Method: The ICF-CY based questionnaire for children with autism comprised 118 items was designed with reference the ICF-CY structure. The study protocol was divided into two parts. In the first part, the inter-rater reliability of the questionnaire was investigated using information from 26 children (aged 3-6 years) with autism and using the intra-class correlation coefficients to estimate reliability. The second part of the study aimed to assess functional performance of another independent sample (136 children, aged 3-6 years) utilizing the questionnaire. Mean scores were compared by nonparametric statistic. Results: The inter-rater reliability for each domains of the questionnaire was found to be moderate to high (intra-class correlation coefficients ranged from 0.72 to 0.97). Children with autism had major problems in voice and speech functions. They had high dependency when executing individual activities of learning and applied knowledge. They also required maximal assistance while engaging in social activities related to conversation and major life categories. Conclusions: This preliminary study shows that ICF-CY based questionnaire has good reliability and can reflect the functional profile of preschool children with autism. However, further study is needed to confirm other psychometric characteristics.
C1 [Gan, Shu-Mei; Yeh, Chun-Yu; Wang, Chun-Hou] Chung Shan Med Univ Hosp, Taichung, Taiwan.
   [Tung, Li-Chen] Chi Mei Med Ctr, Dept Phys Med & Rehabil, Tainan, Taiwan.
   [Yeh, Chun-Yu; Wang, Chun-Hou] Chung Shan Med Univ, Sch Phys Therapy, Taichung 40201, Taiwan.
RP Wang, CH (reprint author), Chung Shan Med Univ, Sch Phys Therapy, 110,Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.
EM chwang@csmu.edu.tw
FU National Science Council, Taiwan [NSC 96-2314-B-040-010-MY3]
FX All authors state that they have no commercial, financial or personal
   relationships which could lead to a conflict of interest that could
   inappropriately influence (bias) their work. The sponsors of the
   research grant had no involvement in the study design; in the
   collection, analysis and interpretation of data; in the writing of the
   manuscript; or in the decision to submit the manuscript for publication.
   This study was partially supported by research grants from the National
   Science Council, Taiwan (NSC 96-2314-B-040-010-MY3).
CR Abhyankar A., 2006, USE ICF CY VERY YOUN
   Abidin R R, 1989, Child Health Care, V18, P114, DOI 10.1207/s15326888chc1802_9
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Australian Institute of Health and Welfare, 2003, ICF AUSTR US GUID VE
   Baghdadli A, 2007, ACTA PSYCHIAT SCAND, V115, P403, DOI 10.1111/j.1600-0447.2006.00898.x
   Baron-Cohen S., 1994, UNDERSTANDING OTHER
   Baron-Cohen S, 1997, HDB AUTISM PERVASIVE, P880
   Battaglia M, 2004, DEV MED CHILD NEUROL, V46, P98
   Beadle-Brown J, 2002, J AUTISM DEV DISORD, V32, P195, DOI 10.1023/A:1015401814041
   Bishop SL, 2007, AM J MENT RETARD, V112, P450, DOI 10.1352/0895-8017(2007)112[450:POPNII]2.0.CO;2
   Bjorck-Akesson E, 2010, DISABIL REHABIL, V32, pS125, DOI 10.3109/09638288.2010.516787
   Bonanni P, 2009, DISABIL REHABIL, V31, pS121, DOI 10.3109/09638280903317872
   Bromley J, 2004, AUTISM, V8, P409, DOI 10.1177/1362361304047224
   Brookman-Frazee L, 2006, CLIN CHILD FAM PSYCH, V9, P181, DOI 10.1007/s10567-006-0010-4
   COHEN J, 1968, PSYCHOL BULL, V70, P213, DOI 10.1037/h0026256
   Ekas NV, 2010, J AUTISM DEV DISORD, V40, P1274, DOI 10.1007/s10803-010-0986-y
   Fombonne E, 2001, J AM ACAD CHILD PSY, V40, P820, DOI 10.1097/00004583-200107000-00017
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   GILL MJ, 1991, J AUTISM DEV DISORD, V21, P407, DOI 10.1007/BF02206867
   Haley SM, 1992, PEDIAT EVALUATION DI
   Hall Heather R, 2011, Issues Compr Pediatr Nurs, V34, P4, DOI 10.3109/01460862.2011.555270
   Hassall R, 2005, J INTELL DISABIL RES, V49, P405, DOI 10.1111/j.1365-2788.2005.00673.x
   Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x
   Holmes E, 2005, J INTELLECT DEV DIS, V30, P156, DOI 10.1080/13668250500204034
   Ibragimova N, 2009, DEV NEUROREHABIL, V12, P3, DOI 10.1080/17518420902777001
   Jordan R, 2005, Pediatr Rehabil, V8, P104
   Kronk RA, 2005, DISABIL REHABIL, V27, P977, DOI 10.1080/09638280500052849
   Lollar DJ, 2005, J DEV BEHAV PEDIATR, V26, P323, DOI 10.1097/00004703-200508000-00012
   McCluggage WG, 1996, J CLIN PATHOL, V49, P833, DOI 10.1136/jcp.49.10.833
   McCormack J, 2010, J COMMUN DISORD, V43, P378, DOI 10.1016/j.jcomdis.2010.04.009
   McLeod S, 2006, ADV SPEECH LANG PATH, V8, P293, DOI 10.1080/14417040600824944
   MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x
   Okochi Jiro, 2005, Health Qual Life Outcomes, V3, P46, DOI 10.1186/1477-7525-3-46
   Ostensjo S, 2006, DISABIL REHABIL, V28, P489, DOI 10.1080/09638280500212013
   Ottenbacher KJ, 2000, ARCH PHYS MED REHAB, V81, P1317, DOI 10.1053/apmr.2000.9387
   OTTENBACHER KJ, 1993, AM J PHYS MED REHAB, V72, P266, DOI 10.1097/00002060-199310000-00003
   Perry R, 2004, J AM ACAD CHILD PSY, V43, P1445, DOI 10.1097/01.chi.0000140451.43582.f8
   Portney L. G., 1993, FDN CLIN RES APPL PR
   Provost B, 2007, J AUTISM DEV DISORD, V37, P321, DOI 10.1007/s10803-006-0170-6
   Robertson JM, 1999, J AM ACAD CHILD PSY, V38, P738, DOI 10.1097/00004583-199906000-00022
   Rutherford MD, 2007, J AUTISM DEV DISORD, V37, P1024, DOI 10.1007/s10803-006-0240-9
   Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038
   Shattuck PT, 2007, J AUTISM DEV DISORD, V37, P1735, DOI 10.1007/s10803-006-0307-7
   SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420
   Starrost K, 2008, PHYS THER, V88, P841, DOI 10.2522/ptj.20070211
   Tadevosyan-Leyfer O, 2003, J AM ACAD CHILD PSY, V42, P864, DOI 10.1097/01.CHI.0000046870.56865.90
   Tanguay PE, 1998, J AM ACAD CHILD PSY, V37, P271, DOI 10.1097/00004583-199803000-00011
   Uchino B. N., 2004, SOCIAL SUPPORT PHYS
   Uhlig T, 2007, ANN RHEUM DIS, V66, P1078, DOI 10.1136/ard.2006.058693
   Vacca JJ, 2007, FOCUS AUTISM OTHER D, V22, P51, DOI 10.1177/10883576070220010601
   van Lang NDJ, 2006, J CHILD PSYCHOL PSYC, V47, P37, DOI 10.1111/j.1469-7610.2005.01434.x
   Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009
   World Health Organisation, 2001, INT CLASS FUNCT DIS
   World Health Organization, 2003, ICF CY CHECKL VERS 1
   World Health Organization (WHO), 2007, INT CLASS FUNCT DIS
NR 55
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0963-8288
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2013
VL 35
IS 8
BP 678
EP 685
DI 10.3109/09638288.2012.705946
PG 8
WC Rehabilitation
SC Rehabilitation
GA 107JE
UT WOS:000316211800006
PM 22897818
ER

PT J
AU Girenok, F
AF Girenok, Fedor
TI On Philosophy
SO METAPHILOSOPHY
LA English
DT Article
DE progress; consciousness; language; speech; autism; emotion; sign; symbol
AB In this article the author holds that progress in philosophy is a vague concept. Its criteria are not universally acknowledged. All that is clear is that philosophy does not develop in a linear way. Philosophy is polydiscoursive. As for the past fifty years, the author believes three important things happened in philosophy. (1) It has been shown that consciousness exists not within one individual but spreads within a community of people; (2) philosophy has discovered autism, a result that helps us to understand a human being as neither a biological nor a social individual but a third thinga dreaming being who is not only asocial but also tongueless, where speech and consciousness are separated; and (3) contemporary philosophy has learned to distinguish between sign and symbol. And it has been realized that the human mind is neither an instinct nor a computer but an objectified suffering, a transformed emotion.
C1 Moscow MV Lomonosov State Univ, Fac Philosophy, Moscow 119991, Russia.
RP Girenok, F (reprint author), Moscow MV Lomonosov State Univ, Fac Philosophy, GSP-1, Moscow 119991, Russia.
EM antrop@philos.msu.ru
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0026-1068
J9 METAPHILOSOPHY
JI Metaphilosophy
PD JAN
PY 2013
VL 44
IS 1-2
BP 29
EP 31
DI 10.1111/meta.12005
PG 3
WC Philosophy
SC Philosophy
GA 066XK
UT WOS:000313255200008
ER

PT J
AU [Anonymous]
AF [Anonymous]
TI Young Adults with Autism Attracted to STEM Majors in College
SO PEDIATRIC ANNALS
LA English
DT Editorial Material
CR Wei X, 2013, J AUTISM DEV DISORD, V43, P1539, DOI 10.1007/s10803-012-1700-z
NR 1
TC 0
Z9 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0090-4481
EI 1938-2359
J9 PEDIATR ANN
JI Pediatr. Annu.
PD JAN
PY 2013
VL 42
IS 1
PG 1
WC Pediatrics
SC Pediatrics
GA 107VC
UT WOS:000316247900010
ER

PT J
AU Romero-Martinez, A
   de Andres-Garcia, S
   Sarinana-Gonzalez, P
   Sanchis-Calatayud, MV
   Roa, JM
   Gonzalez-Bono, E
   Moya-Albiol, L
AF Romero-Martinez, Angel
   de Andres-Garcia, Sara
   Sarinana-Gonzalez, Patricia
   Sanchis-Calatayud, M. V.
   Roa, Juan M.
   Gonzalez-Bono, Esperanza
   Moya-Albiol, L.
TI The 2D:4D ratio and its relationship with other androgenisation
   parameters in parents of individuals with autism spectrum disorders
SO ANALES DE PSICOLOGIA
LA English
DT Article
DE androgenisation; cortisol; 2D:4D ratio; autism spectrum disorders;
   testosterone
ID FINGER LENGTH RATIO; 4TH DIGIT RATIO; EMPATHY QUOTIENT EQ; MALE BRAIN
   THEORY; FETAL TESTOSTERONE; SEX-DIFFERENCES; 2ND; 2D-4D; WOMEN; 2D/4D
AB The 2D:4D ratio is the quotient between the index and ring finger lengths and is a non-direct indicator of androgenisation. If prenatal testosterone levels in the amniotic fluid are high then the probability increases of developing lower ratio values. It has been suggested that people with autism spectrum disorders (ASD) and their parents may have highly androgenised brains, and for this reason the 2D:4D ratio is used as a marker of such idiosyncrasies. This study aims to analyse if parents of people with ASD differ from the general population in several parameters of androgenisation related to the 2D:4D ratio. The sample was composed of 43 parents of offspring with ASD and 42 controls who had the 2D:4D ratio measured, answered several trait questionnaires, and had their testosterone and cortisol levels measured. Although there were no differences between groups in the 2D:4D ratio, the left hand of the ASD parents showed greater predictive ability to explain empathy and autism quotients, cooperative behaviour, and cortisol levels. In addition, the severity of the symptoms of their offspring was predicted only with male parents. The results indicate that the 2D:4D ratio could be used together with other parameters as an indicator of the likelihood of developing autistic traits in offspring.
C1 [Romero-Martinez, Angel; de Andres-Garcia, Sara; Sarinana-Gonzalez, Patricia; Sanchis-Calatayud, M. V.; Roa, Juan M.; Gonzalez-Bono, Esperanza; Moya-Albiol, L.] Univ Valencia, Fac Psychol, Dept Psychobiol, Valencia 46010, Spain.
RP Moya-Albiol, L (reprint author), Univ Valencia, Fac Psychol, Dept Psychobiol, Ave Blasco Ibanez 21, Valencia 46010, Spain.
EM Luis.Moya@uv.es
RI Moya-Albiol, Luis/C-6078-2011
FU Spanish Ministry of Science and Innovation [PSI2008-0448/PSIC];
   Committee for Business, Research and Science of the Regional Government
   of Valencia (Spain) [ACOMP/2010/250, PROME-TEO/2011/048]
FX This study was financed by the Spanish Ministry of Science and
   Innovation (PSI2008-0448/PSIC) and the Committee for Business, Research
   and Science of the Regional Government of Valencia (Spain)
   (ACOMP/2010/250 & PROME-TEO/2011/048).
CR Bailey AA, 2005, BIOL PSYCHOL, V68, P215, DOI 10.1016/j.biopsycho.2004.05.001
   Baron-Cohen S., 2010, AUTISMO SINDROME ASP
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2010, PROG BRAIN RES, V186, P167, DOI 10.1016/B978-0-444-53630-3.00011-7
   Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   Beaton AA, 2011, LATERALITY, V16, P136, DOI 10.1080/13576500903410369
   Benderlioglu Z, 2004, HORM BEHAV, V46, P558, DOI 10.1016/j.yhbeh.2004.06.004
   Breedlove SM, 2010, ENDOCRINOLOGY, V151, P4116, DOI 10.1210/en.2010-0041
   Bull R, 2006, HORM BEHAV, V50, P194, DOI 10.1016/j.yhbeh.2006.02.008
   Buxbaum J.D., 2010, MOL AUTISM, V25, P1
   CLONINGER CR, 1993, ARCH GEN PSYCHIAT, V50, P975
   de Andrés García Sara, 2011, Psicothema, V23, P196
   Derntl B, 2010, PSYCHONEUROENDOCRINO, V35, P67, DOI 10.1016/j.psyneuen.2009.10.006
   Dickmeis T, 2009, J ENDOCRINOL, V200, P3, DOI 10.1677/JOE-08-0415
   Mestre-Escriva V, 2004, PSICOTHEMA, V16, P255
   Gonzalez-Bono E, 2011, ANXIETY STRESS COPIN, V24, P107, DOI 10.1080/10615806.2010.481792
   Greimel E, 2010, NEUROIMAGE, V49, P1055, DOI 10.1016/j.neuroimage.2009.07.057
   Gutierrez-Zotes JA, 2004, ACTAS ESP PSIQUIATRI, V32, P8
   Honekopp J, 2007, PSYCHONEUROENDOCRINO, V32, P313, DOI 10.1016/j.psyneuen.2007.01.007
   Honekopp J, 2010, AM J HUM BIOL, V22, P619, DOI 10.1002/ajhb.21054
   Klump KL, 2006, PSYCHOL MED, V36, P539, DOI 10.1017/S0033291705006653
   Knickmeyer RC, 2006, EARLY HUM DEV, V82, P755, DOI 10.1016/j.earlhumdev.2006.09.014
   Kudielka BM, 2004, PSYCHONEUROENDOCRINO, V29, P83, DOI 10.1016/S0306-4530(02)00146-4
   Lutchmaya S, 2004, EARLY HUM DEV, V77, P23, DOI 10.1016/j.earlhumdev.2003.12.002
   Manning JT, 2003, EVOL HUM BEHAV, V24, P399, DOI 10.1016/S1090-5138(03)00052-7
   Manning JT, 2001, DEV MED CHILD NEUROL, V43, P160, DOI 10.1017/S0012162201000317
   Manning JT, 2000, EVOL HUM BEHAV, V21, P163, DOI 10.1016/S1090-5138(00)00029-5
   Manning JT, 2000, MED HYPOTHESES, V54, P855, DOI 10.1054/mehy.1999.1150
   Manning JT, 2004, ASIAN J ANDROL, V6, P211
   Miguel-Tobal J.J., 2001, ADAPTACION ESPANOLA
   Millet K, 2006, BIOL PSYCHOL, V71, P111, DOI 10.1016/j.biopsycho.2005.06.001
   Moya-Albiol L, 2010, REV NEUROLOGIA, V50, P89
   Nakayama Y., 2007, NEUROENDOCRINOLOGY L, V28, P101
   Rahman Q, 2003, PSYCHONEUROENDOCRINO, V28, P288, DOI 10.1016/S0306-4530(02)00022-7
   Schneider HJ, 2006, PSYCHONEUROENDOCRINO, V31, P265, DOI 10.1016/j.psyneuen.2005.07.005
   Serrano M.A., 2009, ANALES PSICOLOGIA, V25, P150
   Valla JM, 2010, AUTISM RES, V3, P174, DOI 10.1002/aur.143
   van Honka J, 2011, P NATL ACAD SCI USA, V108, P3448, DOI 10.1073/pnas.1011891108
   Van den Bergh B, 2006, P R SOC B, V273, P2091, DOI 10.1098/rspb.2006.3550
   Von Horn A, 2010, SCAND J PSYCHOL, V51, P31, DOI 10.1111/j.1467-9450.2009.00725.x
   Voracek M, 2009, AM J PHYS ANTHROPOL, V140, P376, DOI 10.1002/ajpa.21105
   Wakabayashi A, 2006, PERS INDIV DIFFER, V41, P929, DOI 10.1016/j.paid.2006.03.017
   Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012
   Wheelwright S., 2010, MOL AUTISM, V17, P1
   Wheelwright S., 2004, J AUTISM DEV DISORD, V34, P162
NR 46
TC 6
Z9 6
PU UNIV MURCIA
PI MURCIA
PA SERVICIO DE PUBLICACIONES, CALLE VISTALEGRE S/N, MURCIA, 30007, SPAIN
SN 0212-9728
J9 AN PSICOL-SPAIN
JI An. Psicol.
PD JAN
PY 2013
VL 29
IS 1
BP 264
EP 271
DI 10.6018/analesps.29.1.135501
PG 8
WC Psychology; Psychology, Multidisciplinary
SC Psychology
GA 051FG
UT WOS:000312111000031
ER

PT J
AU St Clair, D
AF St Clair, David
TI Structural and copy number variants in the human genome: implications
   for psychiatry
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Editorial Material
ID SCHIZOPHRENIA; AUTISM
AB Copy number variants are small chromosomal deletions and duplications. When they alter the dose of genes critical for normal brain development and adult brain functioning they may cause severe disorders such as autism and schizophrenia. Numerous such loci have recently been identified. They are offering amazing leads for neuropsychiatric research.
C1 Univ Aberdeen, Div Appl Med, Aberdeen, Scotland.
RP St Clair, D (reprint author), Univ Aberdeen, Div Appl Med, Fosterhill, Aberdeen, Scotland.
EM d.stclair@abdn.ac.uk
CR Alkan C, 2011, NAT REV GENET, V12, P363, DOI 10.1038/nrg2958
   International Schizophrenia Consortium, 2008, NATURE, V445, P237
   Kidd JM, 2008, NATURE, V453, P56, DOI 10.1038/nature06862
   Levy D, 2011, NEURON, V70, P885
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   St Clair D, 2009, SCHIZOPHRENIA BULL, V35, P9, DOI 10.1093/schbul/sbn147
   Stefansson H, 2008, NATURE, V455, P232, DOI 10.1038/nature07229
   Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
NR 10
TC 4
Z9 4
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
   ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JAN
PY 2013
VL 202
IS 1
BP 5
EP 6
DI 10.1192/bjp.bp.112.109579
PG 2
WC Psychiatry
SC Psychiatry
GA 100ZR
UT WOS:000315745000003
PM 23284145
ER

PT J
AU Enticott, PG
   Oberman, LM
AF Enticott, Peter G.
   Oberman, Lindsay M.
TI Synaptic plasticity and non-invasive brain stimulation in autism
   spectrum disorders
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Editorial Material
ID EXCITABILITY
C1 [Enticott, Peter G.] The Alfred, Monash Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia.
   [Oberman, Lindsay M.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Neurol, Childrens Hosp,Sch Med, Boston, MA 02215 USA.
   [Enticott, Peter G.] Monash Univ, Cent Clin Sch, Melbourne, Vic 3004, Australia.
RP Enticott, PG (reprint author), The Alfred, Monash Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia.
CR Enticott PG, 2010, DEV MED CHILD NEUROL, V52, pe179, DOI 10.1111/j.1469-8749.2010.03665.x
   Enticott PG, 2012, NEUROPHARMACOLOGY
   Jung NH, 2013, DEV MED CHILD NEUROL, V55, P83, DOI 10.1111/dmcn.12012
   Oberman L, 2012, EUR J NEUROSCI, V36, P2782, DOI 10.1111/j.1460-9568.2012.08172.x
NR 4
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD JAN
PY 2013
VL 55
IS 1
BP 13
EP 14
DI 10.1111/dmcn.12042
PG 2
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 053VB
UT WOS:000312301700008
PM 23157461
ER

PT J
AU Gallese, V
   Rochat, MJ
   Berchio, C
AF Gallese, Vittorio
   Rochat, Magali J.
   Berchio, Cristina
TI The mirror mechanism and its potential role in autism spectrum disorder
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Editorial Material
AB The mirror mechanism allows the direct translation of a perceived (seen, felt, heard) action into the same motor representation of its related goal. This mechanism allows a direct comprehension of others goals and motor intentions, enabling an embodied link between individuals. Because the mirror mechanism is a functional expression of the motor system, these findings suggest the relevance of the motor system to social cognition. It has been hypothesized that the impaired understanding of others intentions, sensations, and emotions reported in autism spectrum disorder (ASD) could be linked to an alteration of the mirror mechanism in all of these domains. In this review, we address the theoretical issues underlying the social impairments in ASD and discuss them in relation to the cognitive role of the mirror mechanism.
C1 [Gallese, Vittorio; Rochat, Magali J.; Berchio, Cristina] Univ Parma, Dept Neurosci, Physiol Sect, I-43100 Parma, Italy.
   [Gallese, Vittorio] Italian Inst Technol, Brain Ctr Social & Motor Cognit, Parma, Italy.
RP Gallese, V (reprint author), Univ Parma, Dept Neurosci, Physiol Sect, Via Volturno 39-E, I-43100 Parma, Italy.
EM vittorio.gallese@unipr.it
FU EU; European Research Council; Fondazione Monte
FX This work was supported by the EU grants TESIS and Rossi to VG, the
   European Research Council Grant CogSystem to MJR, and Fondazione Monte
   to CB.
NR 0
TC 18
Z9 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD JAN
PY 2013
VL 55
IS 1
BP 15
EP 22
DI 10.1111/j.1469-8749.2012.04398.x
PG 8
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 053VB
UT WOS:000312301700009
PM 22924341
ER

PT J
AU Jung, NH
   Janzarik, WG
   Delvendahl, I
   Munchau, A
   Biscaldi, M
   Mainberger, F
   Baumer, T
   Rauh, R
   Mall, V
AF Jung, Nikolai H.
   Janzarik, Wibke G.
   Delvendahl, Igor
   Muenchau, Alexander
   Biscaldi, Monica
   Mainberger, Florian
   Baeumer, Tobias
   Rauh, Reinhold
   Mall, Volker
TI Impaired induction of long-term potentiation-like plasticity in patients
   with high-functioning autism and Asperger syndrome
SO DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
LA English
DT Article
ID HUMAN MOTOR CORTEX; PAIRED ASSOCIATIVE STIMULATION; TRANSCRANIAL
   MAGNETIC STIMULATION; CORTICAL PLASTICITY; RETT-SYNDROME; MOUSE MODEL;
   CONNECTIVITY; EXCITABILITY; INHIBITION; MODULATION
AB Aim We aimed to investigate the induction of long-term potentiation (LTP)-like plasticity by paired associative stimulation (PAS) in patients with high-functioning autism and Asperger syndrome (HFA/AS). Method PAS with an interstimulus interval between electrical and transcranial magnetic stimulation of 25 ms (PAS25) was performed in patients with HFA/AS (n=9; eight males, one female; mean age 17y 11mo, SD 4y 5mo) and in typically developing age-matched volunteers (n=9; five males, four females; mean age 22y 4mo, SD 5y 2mo). The amplitude of motor-evoked potentials was measured before PAS25, immediately after stimulation, and 30 minutes and 60 minutes later. A PAS protocol adapted to individual N20 latency (PASN20+2) was performed in six additional patients with HFA/AS. Short-interval intracortical inhibition was measured using paired-pulse stimulation. Results In contrast to the typically developing participants, the patients with HFA/AS did not show a significant increase in motor-evoked potentials after PAS25. This finding could also be demonstrated after adaptation for N20 latency. Short-interval intracortical inhibition of patients with HFA/AS was normal compared with the comparison group and did not correlate with PAS effect. Interpretation Our results show a significant impairment of LTP-like plasticity induced by PAS in individuals with HFA/AS compared with typically developing participants. This finding is in accordance with results from animal studies as well as human studies. Impaired LTP-like plasticity in patients with HFA/AS points towards reduced excitatory synaptic connectivity and deficits in sensory-motor integration in these patients.
C1 [Jung, Nikolai H.; Mall, Volker] Tech Univ Munich, Dept Paediat, Munich, Germany.
   [Jung, Nikolai H.; Janzarik, Wibke G.; Delvendahl, Igor; Mainberger, Florian; Mall, Volker] Univ Hosp Freiburg, Div Neuropaediat & Muscular Disorders, Dept Paediat & Adolescent Med, Freiburg, Germany.
   [Delvendahl, Igor] European Neurosci Inst Gottingen, Gottingen, Germany.
   [Muenchau, Alexander; Baeumer, Tobias] Univ Med Ctr Hamburg Eppendorf UKE, Dept Neurol, Hamburg, Germany.
   [Biscaldi, Monica; Rauh, Reinhold] Univ Hosp Freiburg, Dept Child & Adolescent Psychiat & Psychotherapy, Freiburg, Germany.
RP Mall, V (reprint author), Kinderzentrum Munchen Gemeinnutzige GmbH, Heiglhofstr 63, D-81377 Munich, Germany.
EM volker.mall@tum.de
RI Delvendahl, Igor/A-7176-2013
OI Delvendahl, Igor/0000-0002-6151-2363
FU Deutsche Forschungsgemeinschaft [MA 3306/4-1]
FX We thank the volunteers who participated in this study. The study was
   supported by a grant from Deutsche Forschungsgemeinschaft (MA 3306/4-1).
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Awiszus F, 2003, SUPPL CLIN NEUROPHYS, V56, P13
   BRASILNETO JP, 1992, J CLIN NEUROPHYSIOL, V9, P132, DOI 10.1097/00004691-199201000-00014
   Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582
   Chen WG, 2003, SCIENCE, V302, P885, DOI 10.1126/science.1086446
   Classen J, 2004, CLIN NEUROPHYSIOL, V57, P563
   Dani VS, 2009, J NEUROSCI, V29, P11263, DOI 10.1523/JNEUROSCI.1019-09.2009
   Delvendahl I, 2010, CLIN NEUROPHYSIOL, V121, P594, DOI 10.1016/j.clinph.2009.09.034
   Enticott PG, 2010, DEV MED CHILD NEUROL, V52, pe179, DOI 10.1111/j.1469-8749.2010.03665.x
   Enticott PG, 2009, DEV MED CHILD NEUROL, V51, P787, DOI 10.1111/j.1469-8749.2009.03270.x
   Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7
   Fathi D, 2010, CLIN NEUROPHYSIOL, V121, P90, DOI 10.1016/j.clinph.2009.07.048
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Freitag CM, 2007, J AUTISM DEV DISORD, V37, P948, DOI 10.1007/s10803-006-0235-6
   Jung NH, 2010, BRAIN STIMUL, V3, P87, DOI 10.1016/j.brs.2009.10.003
   Kaneko K, 1996, ELECTROMYOGR MOTOR C, V101, P478, DOI 10.1016/S0921-884X(96)96021-X
   KUJIRAI T, 1993, J PHYSIOL-LONDON, V471, P501
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Moretti P, 2006, J NEUROSCI, V26, P319, DOI 10.1523/JNEUROSCI.2623-05.2006
   Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088
   Florian J, 2007, EUR J NEUROSCI, V25, P3461, DOI 10.1111/j.1460-9568.2007.05603.x
   Muller-Dahlhaus JFM, 2008, EXP BRAIN RES, V187, P467, DOI 10.1007/s00221-008-1319-7
   Nagarajan Raman P, 2006, Epigenetics, V1, pe1
   Noterdaeme M, 2010, EUR CHILD ADOLES PSY, V19, P475, DOI 10.1007/s00787-009-0057-0
   Oberman Lindsay, 2010, Front Synaptic Neurosci, V2, P26, DOI 10.3389/fnsyn.2010.00026
   Oblak AL, 2011, BRAIN RES, V1380, P218, DOI 10.1016/j.brainres.2010.09.021
   Ridding MC, 2006, EXP BRAIN RES, V171, P551, DOI 10.1007/s00221-005-0309-2
   Rioult-Pedotti MS, 2000, SCIENCE, V290, P533, DOI 10.1126/science.290.5491.533
   Rossi S, 2009, CLIN NEUROPHYSIOL, V120, P2008, DOI 10.1016/j.clinph.2009.08.016
   Stefan K, 2004, J NEUROPHYSIOL, V92, P66, DOI 10.1152/jn.00383.2003
   Stefan K, 2000, BRAIN, V123, P572, DOI 10.1093/brain/123.3.572
   Stefan K, 2005, J NEUROSCI, V25, P9339, DOI 10.1523/JNEUROSCI.2282.05.2005
   Stefan K, 2006, CEREB CORTEX, V16, P376, DOI 10.1093/cercorbhi116
   Weia RH, 1998, BASIC INTELLIGENCE T
   Wolters A, 2003, J NEUROPHYSIOL, V89, P2339, DOI 10.1152/jn.00900.2002
   World Health Organization, 1994, INT CLASS DIS
   Ziemann U, 2006, CLIN NEUROPHYSIOL, V59, P19
   Ziemann U, 2004, J NEUROSCI, V24, P1666, DOI 10.1523/JNEUROSCI.5016-03.2004
   Ziemann U, 1998, J NEUROSCI, V18, P7000
   Ziemann U, 2001, BRAIN, V124, P1171, DOI 10.1093/brain/124.6.1171
NR 41
TC 7
Z9 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1622
J9 DEV MED CHILD NEUROL
JI Dev. Med. Child Neurol.
PD JAN
PY 2013
VL 55
IS 1
BP 83
EP 89
DI 10.1111/dmcn.12012
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 053VB
UT WOS:000312301700017
PM 23157428
ER

PT J
AU Almansour, MA
   Alateeq, MA
   Alzahrani, MK
   Algeffari, MA
   Alhomaidan, HT
AF Almansour, Mohammed A.
   Alateeq, Mohammed A.
   Alzahrani, Mansour K.
   Algeffari, Metab A.
   Alhomaidan, Homaidan T.
TI Depression and anxiety among parents and caregivers of autistic spectral
   disorder children
SO NEUROSCIENCES
LA English
DT Article
ID PSYCHIATRIC-DISORDERS; HOSPITAL ANXIETY; INTELLECTUAL DISABILITIES;
   INTERVENTION; STRESS; SCALE; SYMPTOMS; SIBLINGS; MOTHERS; FAMILY
AB Objectives: To evaluate the presence of depression and anxiety in parents/caregivers of autistic spectral disorder (ASD) children, and to identify associated factors.
   Methods: In this retrospective cohort study carried out between July and December 2011, parents/caregivers of at least one child diagnosed with an ASD (cases group), were recruited through the Saudi Charitable Society of Autism Families and the Autism Clinic in the Pediatric out-patient clinic in King Fahad National Guard Hospital, King Abdulaziz Medical City (KAMC), Riyadh, Kingdom of Saudi Arabia. The parents/caregivers of a normally developed child (control group) were recruited from the Well Child Clinic at King Abdulaziz Medical City, Riyadh. We used a self-reported questionnaire containing questions on demographic data, as well as the Arabic version of the hospital anxiety and depression scale.
   Results: The study included 100 parents/caregivers, 50 cases and 50 controls. More than 50% of the control group was in the age group 26-30 years (56%), while 42% of cases were in the age group 31-35 years. Time lapsed since autism diagnosis was over 3 years in one-third of cases. Twenty-two percent of cases, and only 2% of control parents/caregivers had a history of psychiatric problems (p=0.002). Both the mean depression score, and the mean anxiety score was significantly higher among cases when compared with controls, p<0.001.
   Conclusion: Autism is associated with burden and stress for parents/caregivers of the affected child. The demands placed by the disability contribute to a higher overall incidence of depression and anxiety among parents/caregivers. Neurosciences 2013; Vol. 18 (1): 58-63
C1 [Almansour, Mohammed A.; Alzahrani, Mansour K.] Almajmaah Univ, Fac Med, Dept Family Med, Almajmaah 11952, Saudi Arabia.
   [Alateeq, Mohammed A.] King Abdul Aziz Med City, King Fahad Natl Guard Hosp, Program Med, Riyadh, Saudi Arabia.
   [Algeffari, Metab A.; Alhomaidan, Homaidan T.] Alqasim Univ, Fac Med, Dept Family Med, Alqasim, Saudi Arabia.
RP Almansour, MA (reprint author), Almajmaah Univ, Fac Med, POB 66, Almajmaah 11952, Saudi Arabia.
EM abu.amerah@hotmail.com
CR Al-Salehi SM, 2009, TRANSCULT PSYCHIATRY, V46, P340, DOI 10.1177/1363461509105823
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT, P69
   [Anonymous], AUT SPECTR DIS DAT S
   Bitsika V., 2004, AUSTR J GUIDANCE COU, V14, P151
   Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004
   BRISTOL MM, 1993, REHABIL PSYCHOL, V38, P3, DOI 10.1037//0090-5550.38.1.3
   Dunn ME, 2001, COMMUNITY MENT HLT J, V37, P39, DOI 10.1023/A:1026592305436
   ELRUFAIE OEF, 1995, SOC PSYCH PSYCH EPID, V30, P26, DOI 10.1007/BF00784431
   Fisman S, 2000, CAN J PSYCHIAT, V45, P369
   FISMAN SN, 1989, CAN J PSYCHIAT, V34, P519
   Gallagher S, 2008, J PEDIATR PSYCHOL, V33, P1129, DOI 10.1093/jpepsy/jsn040
   Gerber JS, 2009, CLIN INFECT DIS, V48, P456, DOI 10.1086/596476
   Gray David E., 1992, Australia and New Zealand Journal of Developmental Disabilities, V18, P83
   HARRIS SL, 1984, FAM RELAT, V33, P127, DOI 10.2307/584597
   Hastings RP, 2003, J AUTISM DEV DISORD, V33, P99, DOI 10.1023/A:1022290723442
   Hastings RP, 2004, J CHILD PSYCHOL PSYC, V45, P1338, DOI 10.1111/j.1469-7610.2004.00357.x
   Herrmann C, 1997, J PSYCHOSOM RES, V42, P17, DOI 10.1016/S0022-3999(96)00216-4
   Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   Karst JS, 2012, CLIN CHILD FAM PSYCH, V15, P247, DOI 10.1007/s10567-012-0119-6
   KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P205, DOI 10.1007/BF01058151
   Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x
   PIVEN J, 1991, J AM ACAD CHILD PSY, V30, P471, DOI 10.1097/00004583-199105000-00019
   Veisson M, 1999, SOC BEHAV PERSONAL, V27, P87, DOI 10.2224/sbp.1999.27.1.87
   Yim Shin Young, 1996, Yonsei Medical Journal, V37, P380
   Yirmiya N, 2005, J CHILD PSYCHOL PSYC, V46, P69, DOI 10.1111/j.1469-7610.2004.00334.x
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 30
TC 2
Z9 3
PU RIYADH ARMED FORCES HOSPITAL
PI RIYADH
PA PO BOX 7897, RIYADH, KSA 11159, SAUDI ARABIA
SN 1319-6138
J9 NEUROSCIENCES
JI Neurosciences
PD JAN
PY 2013
VL 18
IS 1
BP 58
EP 63
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 101BL
UT WOS:000315750100010
PM 23291799
ER

PT J
AU Darwiche, J
   Favez, N
   Maillard, F
   Germond, M
   Guex, P
   Despland, JN
   de Roten, Y
AF Darwiche, Joelle
   Favez, Nicolas
   Maillard, Florine
   Germond, Marc
   Guex, Patrice
   Despland, Jean-Nicolas
   de Roten, Yves
TI Couples' Resolution of an Infertility Diagnosis Before Undergoing in
   Vitro Fertilization
SO SWISS JOURNAL OF PSYCHOLOGY
LA English
DT Article
DE emotional reactions; infertility diagnosis; infertility-related stress;
   marital satisfaction; narratives
ID AUTISM SPECTRUM DISORDERS; FERTILITY TREATMENT; MOTHERS RESOLUTION;
   DYADIC ADJUSTMENT; CHILDS DIAGNOSIS; SURVEY RESPONSES; MARITAL QUALITY;
   FOLLOW-UP; STRESS; WOMEN
AB Although the use of assisted reproductive technology has today become more familiar, the suffering associated with the experience of infertility remains. This study assesses the emotional resolution of couples faced with an infertility diagnosis by examining their narratives. Fifty-seven couples were recruited from fertility clinics to participate in a semistructured interview prior to in vitro fertilization. Two aspects of the couples' reactions to the infertility diagnosis were assessed: (1) each individual's capacity to acknowledge the emotional reality of the diagnosis (diagnosis resolution) and (2) the couple's ability to construct a shared meaning of the infertility diagnosis experience (narrative co-construction). Associations between these aspects and self-reported marital satisfaction, infertility-related stress, and diagnosis-related variables were analyzed. 73.7% of women and 61.4% of men had acknowledged the emotional reality of the diagnosis, and their scores for narrative co-construction were comparable to reference samples. Marital satisfaction, but not infertility-related stress, was associated with diagnosis resolution and narrative co-construction. The results indicate the importance of detecting couples with fewer individual and marital resources needed to face the reality of the diagnosis. A couple's capacity to perceive the infertility diagnosis as a shared problem is also essential for dealing with this common life event.
C1 [Darwiche, Joelle; Maillard, Florine; Guex, Patrice; Despland, Jean-Nicolas; de Roten, Yves] Univ Lausanne, Dept Psychiat, CH-1015 Lausanne, Switzerland.
   [Favez, Nicolas] Univ Geneva, Fac Psychol & Sci Educ, CH-1211 Geneva 4, Switzerland.
   [Germond, Marc] Ctr Medically Assisted Procreat, Lausanne, Switzerland.
   [Germond, Marc] FABER Fdn, Lausanne, Switzerland.
RP Darwiche, J (reprint author), Inst Univ Psychotherapie, Ave Morges 10, CH-1004 Lausanne, Switzerland.
EM Joelle.Darwiche@chuv.ch
CR ANDERSON BA, 1987, SOC FORCES, V66, P537, DOI 10.2307/2578754
   AQUILINO WS, 1993, PUBLIC OPIN QUART, V57, P358, DOI 10.1086/269381
   Barnett D, 2006, J FAM PSYCHOL, V20, P100, DOI 10.1037/0893-3200.20.1.100
   BERG BJ, 1991, J BEHAV MED, V14, P11, DOI 10.1007/BF00844765
   Boivin J, 2007, HUM REPROD, V22, P1506, DOI 10.1093/humrep/dem046
   BOIVIN J, 1995, FERTIL STERIL, V63, P801
   Bowlby J., 1980, ATTACHMENT LOSS
   Braverman A.M., 1997, INFERTILITY PSYCHOL, P209
   Brown George William, 1989, LIFE EVENTS ILLNESS
   Brunell A. B., 2007, J SOC CLIN PSYCHOL, V26, P93, DOI [10.1521/jscp.2007.26.1.92, DOI 10.1521/JSCP.2007.26.1.92]
   Buehlman K. T., 1992, J FAMILY PSYCHOL, V5, P295, DOI 10.1037/0893-3200.5.3-4.295
   Chachamovich JR, 2010, J PSYCHOSOM OBST GYN, V31, P101, DOI 10.3109/0167482X.2010.481337
   Coenen-Huther J., 1994, REV SUISSE SOCIOLOGI, V20, P641
   COOK EP, 1987, J COUNS DEV, V65, P465
   Cook R., 1989, J REPROD INFANT PSYC, V7, P87, DOI 10.1080/02646838908403579
   CRANE DR, 1990, J MARRIAGE FAM, V52, P87, DOI 10.2307/352841
   Daigen V, 2000, PERS RELATIONSHIP, V7, P185, DOI 10.1111/j.1475-6811.2000.tb00011.x
   de Mouzon J, 2012, HUM REPROD, V27, P954, DOI 10.1093/humrep/des023
   Dickstein S, 1999, Monogr Soc Res Child Dev, V64, P84, DOI 10.1111/1540-5834.00021
   Dolev S, 2009, PARENT-SCI PRACT, V9, P183, DOI 10.1080/15295190902844332
   Emery M, 2003, HUM REPROD, V18, P2647, DOI 10.1093/humrep/deg501
   Evers AWM, 2001, J CONSULT CLIN PSYCH, V69, P1026, DOI 10.1037//0022-006X.69.6.1026
   Fiese B. H., 1999, MONOGRAPHS SOC RES C, V64, P1, DOI 10.1111/1540-5834.00017
   Fiese BH, 2005, J FAM PSYCHOL, V19, P51, DOI 10.1037/0893-3200.19.1.51
   Fiese B H, 1999, Monogr Soc Res Child Dev, V64, P52, DOI 10.1111/1540-5834.00019
   FREEMAN EW, 1987, ACTA OBSTET GYN SCAN, V66, P517, DOI 10.3109/00016348709015727
   Greil AL, 2010, SOCIOL HEALTH ILL, V32, P140, DOI 10.1111/j.1467-9566.2009.01213.x
   Grotevant H. D., 1999, MONOGRAPHS SOCI RES, V64, P69, DOI 10.1111/1540-5834.00020
   Harata T., 2012, Reproductive Medicine and Biology, V11, P143, DOI 10.1007/s12522-012-0124-y
   Herth K A, 1989, Oncol Nurs Forum, V16, P67
   Johnson M., 1987, PSYCHOL HEALTH, V1, P25, DOI 10.1080/08870448708400312
   Jordan C, 1999, J BEHAV MED, V22, P341, DOI 10.1023/A:1018774019232
   KOROPATNICK S, 1993, FERTIL STERIL, V59, P163
   Krouse RS, 2009, J PSYCHOSOM RES, V66, P227, DOI 10.1016/j.jpsychores.2008.09.009
   KUPST MJ, 1988, J PEDIATR PSYCHOL, V13, P7, DOI 10.1093/jpepsy/13.1.7
   Lalos A, 1999, HUM REPROD, V14, P581, DOI 10.1093/humrep/14.3.581
   Lawson VL, 2010, BRIT J HEALTH PSYCH, V15, P623, DOI 10.1348/135910709X478664
   Levin JB, 1997, J CLIN PSYCHOL MED S, V4, P361, DOI 10.1023/A:1026249317635
   LITT MD, 1992, J BEHAV MED, V15, P171, DOI 10.1007/BF00848324
   Lord B, 2008, J PEDIATR PSYCHOL, V33, P855, DOI 10.1093/jpepsy/jsn020
   Marvin RS, 1996, J CLIN CHILD PSYCHOL, V25, P436, DOI 10.1207/s15374424jccp2504_8
   McCorry NK, 2013, PSYCHO-ONCOLOGY, V22, P692, DOI 10.1002/pon.3054
   Milshtein S, 2010, J AUTISM DEV DISORD, V40, P89, DOI 10.1007/s10803-009-0837-x
   Newton CR, 1999, FERTIL STERIL, V72, P54, DOI 10.1016/S0015-0282(99)00164-8
   Oppenheim D., 2007, ATTACHMENT THEORY CL, P109
   Oppenheim D, 2009, CHILD DEV, V80, P519, DOI 10.1111/j.1467-8624.2009.01276.x
   Oppenheim D, 1996, J NARRAT LIFE HIST, V6, P1
   Patterson JM, 1994, ANN BEHAV MED, V16, P131
   PAULHUS DL, 1984, J PERS SOC PSYCHOL, V46, P598, DOI 10.1037/0022-3514.46.3.598
   PERRY S, 1993, AM J PSYCHIAT, V150, P775
   Peterson BD, 2006, FAM RELAT, V55, P227, DOI 10.1111/j.1741-3729.2006.00372.x
   Peterson BD, 2011, FERTIL STERIL, V95, P1759, DOI 10.1016/j.fertnstert.2011.01.125
   Peterson BD, 2003, FAM PROCESS, V42, P59, DOI 10.1111/j.1545-5300.2003.00059.x
   Pianta R. C., 1993, MANUAL CLASSIF UNPUB
   Pianta R. C., 1992, REACTION DIAGN UNPUB
   Pianta RC, 1996, INF MENTAL HLTH J, V17, P239, DOI 10.1002/(SICI)1097-0355(199623)17:3<239::AID-IMHJ4>3.0.CO;2-J
   Pook M, 2002, J PSYCHOSOM RES, V53, P1147, DOI 10.1016/S0022-3999(02)00341-0
   Raudenbush S., 2004, HLM 6 HIERARCHICAL L
   SABATELLI RM, 1988, FAM RELAT, V37, P338, DOI 10.2307/584573
   Salvatore P, 2001, FERTIL STERIL, V75, P1119, DOI 10.1016/S0015-0282(01)01775-7
   Schmidt L, 2005, HUM REPROD, V20, P3248, DOI 10.1093/humrep/dei193
   Sheeran T, 1997, J PEDIATR PSYCHOL, V22, P197
   Silva S., 2008, MED SOCIOLOGY ONLINE, V3, P4
   SPANIER GB, 1976, J MARRIAGE FAM, V38, P15, DOI 10.2307/350547
   STANTON AL, 1993, HEALTH PSYCHOL, V12, P16, DOI 10.1037//0278-6133.12.1.16
   STANTON AL, 1992, J SOC CLIN PSYCHOL, V11, P1, DOI 10.1521/jscp.1992.11.1.1
   Sudman S., 1974, RESPONSE EFFECTS SUR
   Sundby J, 2007, J PSYCHOSOM OBST GYN, V28, P115, DOI 10.1080/01674820701447447
   Terry DJ, 1998, J PERS SOC PSYCHOL, V74, P1078, DOI 10.1037/0022-3514.74.4.1078
   Vandeleur CL, 2003, SWISS J PSYCHOL, V62, P167, DOI 10.1024//1421-0185.62.3.167
   Verhaak CM, 2005, HUM REPROD, V20, P2253, DOI 10.1093/humrep/dei015
   Verhaak CM, 2001, FERTIL STERIL, V76, P525, DOI 10.1016/S0015-0282(01)01931-8
   VEROFF J, 1993, J MARRIAGE FAM, V55, P326, DOI 10.2307/352805
   Viane I, 2003, PAIN, V106, P65, DOI 10.1016/S0304-3959(03)00291-4
   Wamboldt F. S., 1989, J PSYCHOTHERAPY FAMI, V4, P141, DOI 10.1300/J287v04n03_08
   Wamboldt Frederick S., 1999, MONOGRAPH SOC RES CH, V64, P37, DOI DOI 10.1111/1540-5834.00018
   Webster A., 2002, CURR SOCIOL, V50, P443, DOI DOI 10.1177/0011392102050003009
   WRIGHT J, 1989, INT J FERTIL, V34, P126
NR 78
TC 0
Z9 1
PU VERLAG HANS HUBER
PI BERN 9
PA LANGGASS-STRASSE 76, CH-3000 BERN 9, SWITZERLAND
SN 1421-0185
J9 SWISS J PSYCHOL
JI Swiss J. Psychol.
PY 2013
VL 72
IS 2
BP 91
EP 102
DI 10.1024/1421-0185/a000102
PG 12
WC Psychology, Multidisciplinary
SC Psychology
GA 104MZ
UT WOS:000315999200004
ER

PT J
AU Frye, RE
   Melnyk, S
   MacFabe, DF
AF Frye, R. E.
   Melnyk, S.
   MacFabe, D. F.
TI Unique acyl-carnitine profiles are potential biomarkers for acquired
   mitochondrial disease in autism spectrum disorder
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
DE acyl-carnitines; autism spectrum disorder; clostridia; microbiome;
   mitochondrial disease; propionic acid
ID CHAIN FATTY-ACIDS; DEXTRAN SULFATE SODIUM; PRODUCT PROPIONIC-ACID;
   BLOOD-BRAIN-BARRIER; EXPERIMENTAL COLITIS; METHYLMALONIC ACID; COMPLEX
   ACTIVITIES; COA DEHYDROGENASE; OXIDATIVE STRESS; SOCIAL-BEHAVIOR
AB Autism spectrum disorder (ASD) has been associated with mitochondrial disease (MD). Interestingly, most individuals with ASD and MD do not have a specific genetic mutation to explain the MD, raising the possibility of that MD may be acquired, at least in a subgroup of children with ASD. Acquired MD has been demonstrated in a rodent ASD model in which propionic acid (PPA), an enteric bacterial fermentation product of ASD-associated gut bacteria, is infused intracerebroventricularly. This animal model shows validity as it demonstrates many behavioral, metabolic, neuropathologic and neurophysiologic abnormalities associated with ASD. This animal model also demonstrates a unique pattern of elevations in short-chain and long-chain acyl-carnitines suggesting abnormalities in fatty-acid metabolism. To determine if the same pattern of biomarkers of abnormal fatty-acid metabolism are present in children with ASD, the laboratory results from a large cohort of children with ASD (n = 213) who underwent screening for metabolic disorders, including mitochondrial and fatty-acid oxidation disorders, in a medically based autism clinic were reviewed. Acyl-carnitine panels were determined to be abnormal if three or more individual acyl-carnitine species were abnormal in the panel and these abnormalities were verified by repeated testing. Overall, 17% of individuals with ASD demonstrated consistently abnormal acyl-carnitine panels. Next, it was determined if specific acyl-carnitine species were consistently elevated across the individuals with consistently abnormal acyl-carnitine panels. Significant elevations in short-chain and long-chain, but not medium-chain, acyl-carnitines were found in the ASD individuals with consistently abnormal acyl-carnitine panels-a pattern consistent with the PPA rodent ASD model. Examination of electron transport chain function in muscle and fibroblast culture, histological and electron microscopy examination of muscle and other biomarkers of mitochondrial metabolism revealed a pattern consistent with the notion that PPA could be interfering with mitochondrial metabolism at the level of the tricarboxylic-acid cycle (TCAC). The function of the fatty-acid oxidation pathway in fibroblast cultures and biomarkers for abnormalities in non-mitochondrial fatty-acid metabolism were not consistently abnormal across the subgroup of ASD children, consistent with the notion that the abnormalities in fatty-acid metabolism found in this subgroup of children with ASD were secondary to TCAC abnormalities. Glutathione metabolism was abnormal in the subset of ASD individuals with consistent acylcarnitine panel abnormalities in a pattern similar to glutathione abnormalities found in the PPA rodent model of ASD. These data suggest that there are similar pathological processes between a subset of ASD children and an animal model of ASD with acquired mitochondrial dysfunction. Future studies need to identify additional parallels between the PPA rodent model of ASD and this subset of ASD individuals with this unique pattern of acyl-carnitine abnormalities. A better understanding of this animal model and subset of children with ASD should lead to better insight in mechanisms behind environmentally induced ASD pathophysiology and should provide guidance for developing preventive and symptomatic treatments. Translational Psychiatry (2013) 3, e220; doi:10.1038/tp.2012.143; published online 22 January 2013
C1 [Frye, R. E.; Melnyk, S.] Arkansas Childrens Hosp Res Inst, Dept Pediat, Little Rock, AR 72202 USA.
   [MacFabe, D. F.] Univ Western Ontario, Schulich Sch Med & Dent, Lawson Res Inst, Dept Psychol Neurosci,Kilee Patchell Evans Autism, London, ON, Canada.
   [MacFabe, D. F.] Univ Western Ontario, Schulich Sch Med & Dent, Lawson Res Inst, Dept Psychiat, London, ON, Canada.
RP Frye, RE (reprint author), Arkansas Childrens Hosp Res Inst, Dept Pediat, Slot 512-41B,13 Childrens Way, Little Rock, AR 72202 USA.
EM REFrye@uams.edu
FU GoodLife's Children's Foundation; Autism Research Institute
FX This research was supported in part from generous contributions from
   GoodLife's Children's Foundation and Autism Research Institute to DFM.
   We thank Dr Raymond Thomas (postdoctoral fellow) for published data on
   brain lipids and Drs Stephan Kahler and Anirudh Saronwala for their
   insight into propionic metabolism.
CR Al-Owain M, 2012, JIMD REPORTS, V7, P63
   American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th
   Ashwood P, 2004, J CLIN IMMUNOL, V24, P664, DOI 10.1007/s10875-004-6241-6
   Ashwood Paul, 2004, Clin Dev Immunol, V11, P165, DOI 10.1080/10446670410001722096
   Ashwood P, 2004, AUTOIMMUN REV, V3, P557, DOI 10.1016/j.autrev.2004.07.036
   Bai RK, 2004, ANN NY ACAD SCI, V1011, P304, DOI 10.1196/annals.1293.029
   Bai RK, 2005, J MOL DIAGN, V7, P613, DOI 10.1016/S1525-1578(10)60595-8
   Barollo M, 2011, WORLD J GASTROENTERO, V17, P4099, DOI 10.3748/wjg.v17.i36.4099
   Barton LL, 2009, ADV APPL MICROBIOL, V68, P41, DOI 10.1016/S0065-2164(09)01202-7
   BRASS EP, 1992, J NUTR, V122, P234
   Brusque AM, 2002, NEUROCHEM INT, V40, P593, DOI 10.1016/S0197-0186(01)00130-9
   Calabrese V, 1999, ALCOHOL, V19, P169, DOI 10.1016/S0741-8329(99)00036-1
   Celestino-Soper PBS, 2012, P NATL ACAD SCI USA, V109, P7974, DOI 10.1073/pnas.1120210109
   Chandler RJ, 2009, FASEB J, V23, P1252, DOI 10.1096/fj.08-121848
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Clark-Taylor T, 2004, MED HYPOTHESES, V62, P970, DOI 10.1016/j.mehy.2004.01.011
   CONN AR, 1983, AM J PHYSIOL, V245, pE253
   Corydon MJ, 2001, PEDIATR RES, V49, P18
   COULTER DL, 1991, J CHILD NEUROL, V6, P7, DOI 10.1177/088307389100600102
   DeCastro M, 2005, MOL BRAIN RES, V142, P28, DOI 10.1016/j.molbrainres.2005.09.002
   Faber S, 2009, BIOMARKERS, V14, P171, DOI 10.1080/13547500902783747
   Fallon J, 2005, MED HYPOTHESES, V64, P312, DOI 10.1016/j.mehy.2004.06.023
   Finegold SM, 2002, CLIN INFECT DIS, V35, pS6, DOI 10.1086/341914
   Finegold SM, 2010, ANAEROBE, V16, P444, DOI 10.1016/j.anaerobe.2010.06.008
   Fortin G, 2009, CLIN EXP IMMUNOL, V156, P161, DOI 10.1111/j.1365-2249.2009.03879.x
   Franklin A.E., 2008, AM J BIOCH BIOTECHNO, V4, P146
   Frye R. E., 2012, NAJ MED SCI, V5, P141, DOI [10.7156/v5i3p141, DOI 10.7156/V5I3P141]
   Frye R. E., 2011, Journal of Pediatric Neurology, V9, P427
   Frye RE, 2011, PEDIATR RES, V69, p41R, DOI 10.1203/PDR.0b013e318212f16b
   Frye RE, 2012, J PED NEUROL, V10, P1
   Geier D. A., 2011, MED SCI MONITOR, V17, pP115
   Gil Borlado MC, 2010, PLOS ONE, V5
   Giulivi C, 2010, JAMA-J AM MED ASSOC, V304, P2389, DOI 10.1001/jama.2010.1706
   Graf WD, 2000, J CHILD NEUROL, V15, P357, DOI 10.1177/088307380001500601
   Haas RH, 2008, MOL GENET METAB, V94, P16, DOI 10.1016/j.ymgme.2007.11.018
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Hara H, 1999, J NUTR, V129, P942
   Herbert MR, 2006, NEUROTOXICOLOGY, V27, P671, DOI 10.1016/j.neuro.2006.03.017
   Iwaya H, 2011, J NUTR, V141, P1077, DOI 10.3945/jn.111.138180
   James SJ, 2009, AM J CLIN NUTR, V89, P425, DOI 10.3945/ajcn.2008.26615
   James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366
   Kirby DM, 2007, METHOD CELL BIOL, V80, P93, DOI 10.1016/S0091-679X(06)80004-X
   Lagoutte E, 2010, BBA-BIOENERGETICS, V1797, P1500, DOI 10.1016/j.bbabio.2010.04.004
   Le Poul E, 2003, J BIOL CHEM, V278, P25481, DOI 10.1074/jbc.M301403200
   MacFabe DF, 2007, BEHAV BRAIN RES, V176, P149, DOI 10.1016/j.bbr.2006.07.025
   MacFabe DF, 2011, BEHAV BRAIN RES, V217, P47, DOI 10.1016/j.bbr.2010.10.005
   MacFabe Derrick F., 2012, Microbial Ecology in Health and Disease, V23, P19260, DOI 10.3402/mehd.v23i0.19260
   Mellon AF, 2000, ARCH DIS CHILD, V82, P169, DOI 10.1136/adc.82.2.169
   Melnyk S, 1999, J NUTR BIOCHEM, V10, P490, DOI 10.1016/S0955-2863(99)00033-9
   Miecz D, 2008, J NEUROCHEM, V104, P113, DOI 10.1111/j.1471-4159.2007.05024.x
   Morava E, 2006, NEUROLOGY, V67, P1823, DOI 10.1212/01.wnl.0000244435.27645.54
   Mostafa G. A., 2005, INT J CHILD NEUROPSY, V2, P179
   Munnich A, 2001, AM J MED GENET, V106, P4, DOI 10.1002/ajmg.1391
   Nakao S, 1998, CELL BIOL INT, V22, P331, DOI 10.1006/cbir.1998.0263
   Nguyen NHT, 2007, J NEUROCHEM, V101, P806, DOI 10.1111/j.1471-4159.2006.04397.x
   Pastural E, 2009, PROSTAG LEUKOTR ESS, V81, P253, DOI 10.1016/j.plefa.2009.06.003
   Patel SP, 2010, J NEUROCHEM, V114, P291, DOI 10.1111/j.1471-4159.2010.06764.x
   Perez B, 2003, MOL GENET METAB, V78, P59, DOI 10.1016/S1096-7192(02)00197-X
   Pettenuzzo LF, 2006, INT J DEV NEUROSCI, V24, P45, DOI 10.1016/j.ijdevneu.2005.10.005
   RH DHaas, 2008, MOL GENET METAB, V94, P16
   Roe CR, 1999, MOL GENET METAB, V68, P243, DOI 10.1006/mgme.1999.2911
   Rorig B, 1996, J PHYSIOL-LONDON, V490, P31
   Rossignol DA, 2009, ANN CLIN PSYCHIATRY, V21, P213
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P389, DOI 10.1038/mp.2011.165
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
   Russo A J, 2011, Biomark Insights, V6, P127, DOI 10.4137/BMI.S7286
   Sandler RH, 2000, J CHILD NEUROL, V15, P429, DOI 10.1177/088307380001500701
   Scafidi S, 2010, DEV NEUROSCI-BASEL, V32, P480, DOI 10.1159/000323178
   Schwab MA, 2006, BIOCHEM J, V398, P107, DOI 10.1042/BJ20060221
   Scrimgeour AG, 2009, CURR OPIN CLIN NUTR, V12, P653, DOI 10.1097/MCO.0b013e3283308dd6
   Shultz SR, 2008, NEUROPHARMACOLOGY, V54, P901, DOI 10.1016/j.neuropharm.2008.01.013
   Shultz SR, 2009, BEHAV BRAIN RES, V200, P33, DOI 10.1016/j.bbr.2008.12.023
   Sikora SK, 2011, CLIN PEDIATR, V50, P488, DOI 10.1177/0009922810397041
   Thomas RH, 2010, J NEUROCHEM, V113, P515, DOI 10.1111/j.1471-4159.2010.06614.x
   Thomas RH, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-153
   Tran CD, 2007, DIGEST DIS SCI, V52, P2113, DOI 10.1007/s10620-007-9765-9
   Wajner M, 2004, J INHERIT METAB DIS, V27, P427, DOI 10.1023/B:BOLI.0000037353.13085.e2
   Wang L, 2012, DIGEST DIS SCI, V57, P2096, DOI 10.1007/s10620-012-2167-7
   Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4
   Weissman JR, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003815
   Williams BL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024585
   Wong Lee-Jun C., 2006, V336, P135
   Wong LJC, 2007, MUSCLE NERVE, V36, P279, DOI 10.1002/mus.20807
   Yasuda H, 2011, SCI REP-UK, V1, DOI 10.1038/srep00129
   Yorifuji T, 2002, HUM GENET, V111, P161, DOI 10.1007/s00439-002-0761-z
   Zhang YJ, 2011, LIFE SCI, V88, P432, DOI 10.1016/j.lfs.2010.12.018
NR 86
TC 17
Z9 17
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JAN
PY 2013
VL 3
AR e220
DI 10.1038/tp.2012.143
PG 10
WC Psychiatry
SC Psychiatry
GA 104KV
UT WOS:000315992700015
PM 23340503
ER

PT J
AU Oh, JE
   Chambwe, N
   Klein, S
   Gal, J
   Andrews, S
   Gleason, G
   Shaknovich, R
   Melnick, A
   Campagne, F
   Toth, M
AF Oh, J-E
   Chambwe, N.
   Klein, S.
   Gal, J.
   Andrews, S.
   Gleason, G.
   Shaknovich, R.
   Melnick, A.
   Campagne, F.
   Toth, M.
TI Differential gene body methylation and reduced expression of cell
   adhesion and neurotransmitter receptor genes in adverse maternal
   environment
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
DE CpG island; development; DNA methylation; exon; maternal effect
ID MEDIAL PREFRONTAL CORTEX; IMPAIRED STRESS-RESPONSE; ANXIETY-LIKE
   BEHAVIOR; EARLY-LIFE STRESS; DNA METHYLATION; MICE LACKING; ADULT MICE;
   GLUCOCORTICOID-RECEPTOR; VENTRAL HIPPOCAMPUS; IOMAZENIL-SPECT
AB Early life adversity, including adverse gestational and postpartum maternal environment, is a contributing factor in the development of autism, attention deficit hyperactivity disorder (ADHD), anxiety and depression but little is known about the underlying molecular mechanism. In a model of gestational maternal adversity that leads to innate anxiety, increased stress reactivity and impaired vocal communication in the offspring, we asked if a specific DNA methylation signature is associated with the emergence of the behavioral phenotype. Genome-wide DNA methylation analyses identified 2.3% of CpGs as differentially methylated (that is, differentially methylated sites, DMSs) by the adverse environment in ventral-hippocampal granule cells, neurons that can be linked to the anxiety phenotype. DMSs were typically clustered and these clusters were preferentially located at gene bodies. Although CpGs are typically either highly methylated or unmethylated, DMSs had an intermediate (20-80%) methylation level that may contribute to their sensitivity to environmental adversity. The adverse maternal environment resulted in either hyper or hypomethylation at DMSs. Clusters of DMSs were enriched in genes that encode cell adhesion molecules and neurotransmitter receptors; some of which were also downregulated, indicating multiple functional deficits at the synapse in adversity. Pharmacological and genetic evidence links many of these genes to anxiety. Translational Psychiatry (2013) 3, e218; doi:10.1038/tp.2012.130; published online 22 January 2013
C1 [Oh, J-E; Klein, S.; Gleason, G.; Toth, M.] Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA.
   [Chambwe, N.; Andrews, S.; Campagne, F.] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA.
   [Chambwe, N.; Andrews, S.; Campagne, F.] Weill Cornell Med Coll, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsau, New York, NY 10065 USA.
   [Gal, J.] Rockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY 10021 USA.
   [Shaknovich, R.; Melnick, A.] Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA.
RP Oh, JE (reprint author), Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA.
EM jio2002@med.cornell.edu; mtoth@med.cornell.edu
RI Chambwe, Nyasha/M-7796-2013
FU US National Institute of Mental Health [5RO1MH086883, 1R01MH58669]
FX We thank Yushan Li of the Epigenomics core facility and Dr Jenny Xiang
   of the Genomics Resources Core Facility for technical support. We also
   thank Dr Piali Mukherjee for computational analysis assistance and Drs
   Maria Figueroa, Min seok Song and Sung hyun Kim for technical advice.
   This work was supported by US National Institute of Mental Health grant
   5RO1MH086883 and 1R01MH58669 to MT.
CR Accili D, 1996, P NATL ACAD SCI USA, V93, P1945, DOI 10.1073/pnas.93.5.1945
   Adhikari A, 2010, NEURON, V65, P257, DOI 10.1016/j.neuron.2009.12.002
   Attwood BK, 2011, NATURE, V473, P372, DOI 10.1038/nature09938
   Bannerman DM, 2004, NEUROSCI BIOBEHAV R, V28, P273, DOI 10.1016/j.neubiorev.2004.03.004
   Barkus C, 2010, EUR J PHARMACOL, V626, P49, DOI 10.1016/j.ejphar.2009.10.014
   Borgel J, 2010, NAT GENET, V42, P1093, DOI 10.1038/ng.708
   Catches JS, 2012, BEHAV BRAIN RES, V228, P406, DOI 10.1016/j.bbr.2011.12.026
   Charil A, 2010, BRAIN RES REV, V65, P56, DOI 10.1016/j.brainresrev.2010.06.002
   Chen GH, 2011, BEHAV BRAIN RES, V218, P267, DOI 10.1016/j.bbr.2010.11.001
   Dong Y, 2006, NAT NEUROSCI, V9, P475, DOI 10.1038/nn1661
   Ehrich M, 2005, P NATL ACAD SCI USA, V102, P15785, DOI 10.1073/pnas.0507816102
   Elliott E, 2010, NAT NEUROSCI, V13, P1351, DOI 10.1038/nn.2642
   Figueroa ME, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001882
   Figueroa Maria E., 2009, V538, P395, DOI 10.1007/978-1-59745-418-6_20
   Giannopoulou EG, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-277
   Gilbert R, 2009, LANCET, V373, P68, DOI 10.1016/S0140-6736(08)61706-7
   Gleason G, 2010, P NATL ACAD SCI USA, V107, P7592, DOI 10.1073/pnas.0914805107
   Gleason Georgia, 2011, Front Psychiatry, V2, P25, DOI 10.3389/fpsyt.2011.00025
   Green JG, 2010, ARCH GEN PSYCHIAT, V67, P113, DOI 10.1001/archgenpsychiatry.2009.186
   Gu HC, 2011, NAT PROTOC, V6, P468, DOI 10.1038/nprot.2010.190
   Guo JJU, 2011, NAT NEUROSCI, V14, P1345, DOI 10.1038/nn.2900
   Hodges E, 2011, MOL CELL, V44, P17, DOI 10.1016/j.molcel.2011.08.026
   Irizarry RA, 2009, NAT GENET, V41, P178, DOI 10.1038/ng.298
   Ishikawa A, 2006, J NEUROPHYSIOL, V96, P2134, DOI 10.1152/jn.00069.2006
   Jung CG, 2005, DEVELOPMENT, V132, P5137, DOI 10.1242/dev.02098
   KASCHKA W, 1995, J PSYCHIAT RES, V29, P427, DOI 10.1016/0022-3956(95)00019-2
   Khulan B, 2006, GENOME RES, V16, P1046, DOI 10.1101/gr.5273806
   Kielbasa SM, 2011, GENOME RES, V21, P487, DOI 10.1101/gr.113985.110
   Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011
   Kjelstrup KG, 2002, P NATL ACAD SCI USA, V99, P10825, DOI 10.1073/pnas.152112399
   Ledent C, 1997, NATURE, V388, P674
   Lee AS, 2012, MOL PSYCHIATR, V17, P1054, DOI 10.1038/mp.2012.71
   Lister R, 2009, NATURE, V462, P315, DOI 10.1038/nature08514
   Machold R, 2003, NEURON, V39, P937, DOI 10.1016/S0896-6273(03)00561-0
   McEwen BS, 1999, ANNU REV NEUROSCI, V22, P105, DOI 10.1146/annurev.neuro.22.1.105
   McGowan PO, 2009, NAT NEUROSCI, V12, P342, DOI 10.1038/nn.2270
   Meaney MJ, 2001, ANNU REV NEUROSCI, V24, P1161, DOI 10.1146/annurev.neuro.24.1.1161
   Meissner A, 2008, NATURE, V454, P766, DOI 10.1038/nature07107
   Millstein RA, 2007, NEUROSCI BIOBEHAV R, V31, P3, DOI 10.1016/j.neubiorev.2006.05.003
   Mohn F, 2008, MOL CELL, V30, P755, DOI 10.1016/j.molcel.2008.05.007
   Mombereau C, 2005, NEUROREPORT, V16, P307, DOI 10.1097/00001756-200502280-00021
   Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657
   Muramatsu R, 2007, NEUROSCIENCE, V148, P593, DOI 10.1016/j.neuroscience.2007.06.040
   Murgatroyd C, 2009, NAT NEUROSCI, V12, P1559, DOI 10.1038/nn.2436
   Nemeroff CB Charles B, 2004, Psychopharmacol Bull, V38, P14
   Niehrs C, 2012, TRENDS CELL BIOL, V22, P220, DOI 10.1016/j.tcb.2012.01.002
   Oberlander TF, 2008, EPIGENETICS, V3, P97
   Phillips NK, 2005, J ABNORM CHILD PSYCH, V33, P13, DOI 10.1007/s10802-005-0930-3
   Priebe K, 2005, DEV PSYCHOBIOL, V47, P398, DOI 10.1002/dev.20098
   Qi Y, 2008, P NATL ACAD SCI USA, V105, P2481, DOI 10.1073/pnas.0712196105
   Rollins RA, 2006, GENOME RES, V16, P157, DOI 10.1101/gr.4262006
   Ross SA, 2000, J NEUROSCI, V20, P6431
   Sanchez-Camacho C, 2009, BIOESSAYS, V31, P1013, DOI 10.1002/bies.200900063
   SCHLEGEL S, 1994, EUR ARCH PSY CLIN N, V244, P49, DOI 10.1007/BF02279812
   Smith GW, 1998, NEURON, V20, P1093, DOI 10.1016/S0896-6273(00)80491-2
   Smith ZD, 2012, NATURE, V484, P339, DOI 10.1038/nature10960
   SUTTON RE, 1982, NATURE, V297, P331, DOI 10.1038/297331a0
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Tiihonen J, 1997, MOL PSYCHIATR, V2, P463, DOI 10.1038/sj.mp.4000329
   Timpl P, 1998, NAT GENET, V19, P162, DOI 10.1038/520
   van Velzen A, 2010, GENES BRAIN BEHAV, V9, P877, DOI 10.1111/j.1601-183X.2010.00625.x
   Veenema AH, 2008, ENDOCRINOLOGY, V149, P2727, DOI 10.1210/en.2007-1469
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Wisniowiecka-Kowalnik B, 2010, AM J MED GENET B, V153B, P983, DOI 10.1002/ajmg.b.31064
   Wood SJ, 2001, MOL NEUROBIOL, V23, P101
   Zhang TY, 2010, J NEUROSCI, V30, P13130, DOI 10.1523/JNEUROSCI.1039-10.2010
   Zoghbi HY, 2010, NEURON, V68, P165, DOI 10.1016/j.neuron.2010.10.015
NR 67
TC 7
Z9 7
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JAN
PY 2013
VL 3
AR e218
DI 10.1038/tp.2012.130
PG 12
WC Psychiatry
SC Psychiatry
GA 104KV
UT WOS:000315992700013
PM 23340501
ER

PT J
AU Kelly, DJ
   Walker, R
   Norbury, CF
AF Kelly, David J.
   Walker, Robin
   Norbury, Courtenay Frazier
TI Deficits in volitional oculomotor control align with language status in
   autism spectrum disorders
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; SACCADIC EYE-MOVEMENTS; FIXATION PATTERNS;
   VISUAL FIXATION; 1ST-DEGREE RELATIVES; EXECUTIVE FUNCTION; EXPRESS
   SACCADES; WORKING-MEMORY; CHILDREN; IMPAIRMENT
AB Eye-tracking paradigms are increasingly used to investigate higher-level social and cognitive processing in autism spectrum disorder (ASD). However, the integrity of the oculomotor system within ASD is unclear, with contradictory reports of aberrant eye-movements on basic oculomotor tasks. The purpose of the current study was to determine whether reducing population heterogeneity and distinguishing neurocognitive phenotypes can clarify discrepancies in oculomotor behaviour evident in previous reports. Reflexive and volitional eye-movement control was assessed in 73 children aged 8-14 years from four distinct groups: Autism Language Normal (ALN), Autism Language Impaired (ALI), non-autistic Language Impaired (LI) and Typically Developing (TD). Eye-movement control was measured using pro-and antisaccade tasks and a novel 'search distracter' task to measure distractibility. Reflexive eye-movements were equivalent across groups, but deficits in volitional eye-movement control were found that aligned with language status, and were not specific to ASD. More than 80% of ALI and LI children presented error rates at least 1.5 SDs below the TD mean in an antisaccade task. In the search distracter task, 35.29% of ALI children and 43.75% of LI children had error rates greater than 1.5 SDs compared with 17.64% of ALN children. A significant proportion of children with neurodevelopmental disorders involving language function have pronounced difficulties suppressing reflexive saccades and maintaining fixations in the presence of competing stimuli. We extend the putative link between ALI and LI populations to non-language tasks, and highlight the need to account for co-morbidity in understanding the ontogenesis of ASD.
C1 [Kelly, David J.; Walker, Robin; Norbury, Courtenay Frazier] Univ London, Dept Psychol, London WC1E 7HU, England.
RP Kelly, DJ (reprint author), Royal Holloway Univ London, Dept Psychol, Egham Hill, Egham TW20 0EX, Surrey, England.
EM david.kelly@rhul.ac.uk
CR Benson V, 2011, OXFORD HDB EYE MOVEM, P709
   Benson V, 2009, NEUROPSYCHOLOGIA, V47, P1178, DOI 10.1016/j.neuropsychologia.2008.11.019
   BISHOP DVM, 1992, J SPEECH HEAR RES, V35, P119
   Boraston Z, 2007, J PHYSIOL-LONDON, V581, P893, DOI 10.1113/jphysiol.2007.133587
   Botting N, 2005, J CHILD PSYCHOL PSYC, V46, P317, DOI 10.1111/j.1469-7610.2004.00355.x
   Brenner L., 2008, J AUTISM DEV DISORD, V37, P1289
   Chawarska K, 2010, ARCH GEN PSYCHIAT, V67, P178, DOI 10.1001/archgenpsychiatry.2009.194
   Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
   Elsabbagh M, 2009, J CHILD PSYCHOL PSYC, V50, P637, DOI 10.1111/j.1469-7610.2008.02051.x
   Falck-Ytter T, 2011, PROG BRAIN RES, V189, P209, DOI 10.1016/B978-0-444-53884-0.00026-9
   FISCHER B, 1993, BEHAV BRAIN SCI, V16, P553
   Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016
   Freeth M, 2011, NEUROPSYCHOLOGIA, V49, P156, DOI 10.1016/j.neuropsychologia.2010.11.012
   Gardner M., 1990, RECEPTIVE ONE WORD P
   Goldberg MC, 2002, NEUROPSYCHOLOGIA, V40, P2039, DOI 10.1016/S0028-3932(02)00059-3
   Henry L.A., J CHILD PSY IN PRESS
   Hodge S.M., 2009, J AUTISM DEV DISORD, V40, P300
   Karmiloff-Smith A, 1998, TRENDS COGN SCI, V2, P389, DOI 10.1016/S1364-6613(98)01230-3
   Kemner C, 1998, J AUTISM DEV DISORD, V28, P61, DOI 10.1023/A:1026015120128
   Kirchner JC, 2011, J AUTISM DEV DISORD, V41, P158, DOI 10.1007/s10803-010-1032-9
   Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Kuhn G, 2010, EXP BRAIN RES, V201, P155, DOI 10.1007/s00221-009-2019-7
   Lindgren KA, 2009, AUTISM RES, V2, P22, DOI 10.1002/aur.63
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Loucas T, 2008, J CHILD PSYCHOL PSYC, V49, P1184, DOI 10.1111/j.1469-7610.2008.01951.x
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   Marcovitch S, 2009, DEVELOPMENTAL SCI, V12, P1, DOI 10.1111/j.1467-7687.2008.00754.x
   Minshew NJ, 1999, NEUROLOGY, V52, P917
   Mosconi MW, 2010, ARCH GEN PSYCHIAT, V67, P830, DOI 10.1001/archgenpsychiatry.2010.87
   Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83
   MUNOZ DP, 1992, J NEUROPHYSIOL, V67, P1000
   Munoz DP, 2004, NAT REV NEUROSCI, V5, P218, DOI 10.1038/nrn1345
   Munoz DP, 2003, J NEUROPHYSIOL, V90, P503, DOI 10.1152/jn.00192.2003
   Nation K, 2008, DEV PSYCHOPATHOL, V20, P79, DOI 10.1017/S0954579408000047
   Norbury CF, 2009, J CHILD PSYCHOL PSYC, V50, P834, DOI 10.1111/j.1469-7610.2009.02073.x
   O'Hearn K, 2011, AUTISM RES, V4, P132, DOI 10.1002/aur.179
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
   PIERROTDESEILLIGNY C, 1991, BRAIN, V114, P1473, DOI 10.1093/brain/114.3.1473
   Rayner K, 1998, PSYCHOL BULL, V124, P372, DOI 10.1037/0033-2909.124.3.372
   REUTERLORENZ PA, 1995, EXP BRAIN RES, V103, P287
   Riby DM, 2008, J AUTISM DEV DISORD, V39, P421
   Rice K, 2012, J AM ACAD CHILD PSY, V51, P238, DOI 10.1016/j.jaac.2011.12.017
   ROBERTS RJ, 1994, J EXP PSYCHOL GEN, V123, P374, DOI 10.1037//0096-3445.123.4.374
   Rommelse NNJ, 2008, BRAIN COGNITION, V68, P391, DOI 10.1016/j.bandc.2008.08.025
   ROSENHALL U, 1988, J LARYNGOL OTOL, V102, P435, DOI 10.1017/S0022215100105286
   SASLOW MG, 1967, J OPT SOC AM, V57, P1024, DOI 10.1364/JOSA.57.001024
   Scerif G, 2005, J COGNITIVE NEUROSCI, V17, P591, DOI 10.1162/0898929053467523
   Semel E., 2003, CLIN EVALUATION LANG, V4th
   Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
   Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f
   Stothard SE, 1998, J SPEECH LANG HEAR R, V41, P407
   Tager-Flusberg H, 2003, PHILOS T ROY SOC B, V358, P303, DOI 10.1098/rstb.2002.1198
   Takarae Y, 2004, J NEUROL NEUROSUR PS, V75, P1359, DOI 10.1136/jnnp.2003.022491
   Tomblin B, 2011, INT J LANG COMM DIS, V46, P127, DOI 10.1111/j.1460-6984.2011.00017.x
   van der Geest JN, 2001, BIOL PSYCHIAT, V50, P614, DOI 10.1016/S0006-3223(01)01070-8
   Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828
   Walker R, 1998, NEUROPSYCHOLOGIA, V36, P1141, DOI 10.1016/S0028-3932(98)00004-9
   Wechsler D, 1999, WECHSLER ABBREVIATED
NR 60
TC 9
Z9 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1363-755X
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD JAN
PY 2013
VL 16
IS 1
BP 56
EP 66
DI 10.1111/j.1467-7687.2012.01188.x
PG 11
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA 096DD
UT WOS:000315383300006
PM 23278927
ER

PT J
AU Ewing, L
   Pellicano, E
   Rhodes, G
AF Ewing, Louise
   Pellicano, Elizabeth
   Rhodes, Gillian
TI Atypical updating of face representations with experience in children
   with autism
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID SPECTRUM DISORDERS; RECOGNITION; ADAPTATION; PERCEPTION; IDENTITY;
   UPRIGHT; MEMORY; US
AB Face identity aftereffects are significantly diminished in children with autism relative to typical children, which may reflect reduced perceptual updating with experience. Here, we investigated whether this atypicality also extends to non-face stimulus categories, which might signal a pervasive visual processing difference in individuals with autism. We used a figural aftereffect task to measure directly perceptual updating following exposure to distorted upright faces, inverted faces and cars, in typical children and children with autism. A size-change between study and test stimuli limited the likelihood that any processing atypicalities reflected group differences in adaptation to low-level features of the stimuli. Results indicated that, relative to typical children, figural aftereffects for upright faces, but not inverted faces or cars, were significantly attenuated in children with autism. Moreover, the group difference was amplified when we isolated the 'face-selective' component of the aftereffect, by partialling out the mid-level shape adaptation common to upright and inverted face stimuli. Notably, the aftereffects of typical children were disproportionately larger for upright faces than for inverted faces and cars, but the magnitude of aftereffects of autistic children was not similarly modulated according to stimulus category. These findings are inconsistent with a pervasive adaptive coding atypicality relative to typical children, and suggest that reduced perceptual updating may constitute a high-level, and possibly face-selective, visual processing difference in children with autism.
C1 [Ewing, Louise; Pellicano, Elizabeth; Rhodes, Gillian] Univ Western Australia, Sch Psychol, ARC Ctr Excellence Cognit & Its Disorders, Crawley, WA 6009, Australia.
   [Pellicano, Elizabeth] Univ London, Inst Educ, CRAE, London WC1E 7HU, England.
RP Ewing, L (reprint author), Univ Western Australia, Sch Psychol, 35 Stirling Highway, Crawley, WA 6009, Australia.
EM louise.ewing@uwa.edu.au
RI Ewing, Louise/H-9158-2014
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x
   Chen J, 2010, RADIAT PROT DOSIM, V142, P1, DOI 10.1093/rpd/ncq205
   DAVIES S, 1994, J CHILD PSYCHOL PSYC, V35, P1033, DOI 10.1111/j.1469-7610.1994.tb01808.x
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   Dennett H., PSYCHOL SCI IN PRESS, DOI [10.1111/095679612446350, DOI 10.1111/095679612446350]
   Ewing L., 2012, REEVALUATING S UNPUB
   Field A., 2005, DISCOVERING STAT USI, V2nd
   Gastgeb HZ, 2011, J AUTISM DEV DISORD, V41, P1609, DOI 10.1007/s10803-011-1190-4
   Gastgeb HZ, 2009, AUTISM RES, V2, P279, DOI 10.1002/aur.93
   Glasson EJ, 2008, MED J AUSTRALIA, V188, P288
   Golarai G, 2006, CLIN NEUROSCI RES, V6, P145, DOI 10.1016/j.cnr.2006.08.001
   Grelotti DJ, 2002, DEV PSYCHOBIOL, V40, P213, DOI 10.1002/dev.10028
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Hauck M, 1998, CHILD NEUROPSYCHOL, V4, P187, DOI 10.1076/chin.4.3.187.3174
   Klinger L., 2006, NEW DEV AUTISM FUTUR, P75
   Klinger LG, 2001, DEV PSYCHOPATHOL, V13, P111, DOI 10.1017/S0954579401001080
   Leopold DA, 2001, NAT NEUROSCI, V4, P89, DOI 10.1038/82947
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Molesworth CJ, 2005, J CHILD PSYCHOL PSYC, V46, P661, DOI 10.1111/j.1469-7610.2004.00383.x
   Oruc I, 2011, P ROY SOC B-BIOL SCI, V278, P2591, DOI 10.1098/rspb.2010.2480
   Pellicano E., 2012, CAMBRIDGE FACE UNPUB
   Pellicano E, 2012, AJIDD-AM J INTELLECT, V117, P156, DOI 10.1352/1944-7558-117.2.156
   Pellicano E, 2007, CURR BIOL, V17, P1508, DOI 10.1016/j.cub.2007.07.065
   Rhodes G, 2009, VISION RES, V49, P2379, DOI 10.1016/j.visres.2009.07.010
   Rhodes G, 2006, VISION RES, V46, P2977, DOI 10.1016/j.visres.2006.03.002
   Rhodes G, 2010, VISION RES, V50, P963, DOI 10.1016/j.visres.2010.03.003
   Rhodes G, 2011, VISION RES, V51, P1811, DOI 10.1016/j.visres.2011.06.008
   Robbins R, 2007, J EXP PSYCHOL HUMAN, V33, P570, DOI 10.1037/0096-1523.33.3.570
   Robbins RA, 2012, DEVELOPMENTAL SCI, V15, P194, DOI 10.1111/j.1467-7687.2011.01116.x
   Rossion B, 2008, ACTA PSYCHOL, V128, P274, DOI 10.1016/j.actpsy.2008.02.003
   Rutter M., 2003, SOCIAL COMMUNICATION
   Sasson NJ, 2006, J AUTISM DEV DISORD, V36, P381, DOI 10.1007/s10803-006-0076-3
   Scherf KS, 2008, J CHILD PSYCHOL PSYC, V49, P838, DOI 10.1111/j.1469-7610.2008.01903.x
   Susilo T, 2010, J VISION, V10, DOI 10.1167/10.13.1
   Vladusich T, 2010, AUTISM RES, V3, P226, DOI 10.1002/aur.148
   Webb S. J., 2011, OXFORD HDB FACE PERC, P839
   Webster MA, 1999, PSYCHON B REV, V6, P647, DOI 10.3758/BF03212974
   Webster MA, 2011, J VISION, V11, DOI 10.1167/11.5.3
   Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008
   Yang H., 2010, VISION RES, V51, P105
NR 41
TC 10
Z9 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1363-755X
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD JAN
PY 2013
VL 16
IS 1
BP 116
EP 123
DI 10.1111/desc.12007
PG 8
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA 096DD
UT WOS:000315383300012
PM 23278933
ER

PT J
AU Manstead, ASR
   Dosmukhambetova, D
   Shearn, J
   Clifton, A
AF Manstead, Antony S. R.
   Dosmukhambetova, Dina
   Shearn, Julia
   Clifton, Amy
TI THE INFLUENCE OF DYSPHORIA AND DEPRESSION ON MENTAL STATE DECODING
SO JOURNAL OF SOCIAL AND CLINICAL PSYCHOLOGY
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; FACIAL EXPRESSIONS; COLLEGE-STUDENTS; CLINICAL
   DEPRESSION; ASPERGER-SYNDROME; MAJOR DEPRESSION; HOSPITAL ANXIETY;
   ADULTS; MIND; RECOGNITION
AB Prior research found conflicting results concerning the relationship between depression and mental state decoding ability as assessed by the 'Eyes Test' developed by Baron-Cohen and colleagues. In some studies the relationship is negative, suggesting that depressed persons are worse than controls in decoding mental states on the basis of information from the eye region of others' faces. Other research points to a positive relation between depression and mental state decoding. We report a study of mental state decoding ability in two samples of university students, one a group of students attending the university's counseling service, the other a group of normal college students. The results are consistent in showing a negative relation between depression and mental state decoding ability. Possible reasons for discrepancies in research results are discussed.
C1 [Manstead, Antony S. R.; Dosmukhambetova, Dina; Shearn, Julia; Clifton, Amy] Cardiff Univ, Cardiff CF10 3AT, S Glam, Wales.
RP Manstead, ASR (reprint author), Cardiff Univ, Sch Psychol, Tower Bldg,Pk Pl, Cardiff CF10 3AT, S Glam, Wales.
EM MansteadA@Cardiff.ac.uk
RI Manstead, Antony/D-1476-2009
OI Manstead, Antony/0000-0001-7540-2096
CR Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Beck AT, 1996, MANUAL BECK DEPRESSI, VII
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   Bora E, 2005, ACTA PSYCHIAT SCAND, V112, P110, DOI 10.1111/j.1600-0447.2005.00570.x
   Brown G. W., 1978, SOCIAL ORIGINS DEPRE
   Carton JS, 1999, J NONVERBAL BEHAV, V23, P91, DOI 10.1023/A:1021339410262
   Converse BA, 2008, EMOTION, V8, P725, DOI 10.1037/a0013283
   COYNE JC, 1987, J CONSULT CLIN PSYCH, V55, P347, DOI 10.1037//0022-006X.55.3.347
   Dozois DJA, 1998, PSYCHOL ASSESSMENT, V10, P83, DOI 10.1037/1040-3590.10.2.83
   Edwards J. A., 1994, HDB SOCIAL COGNITION, P289
   GOTLIB IH, 1989, J SOC CLIN PSYCHOL, V8, P223, DOI 10.1521/jscp.1989.8.3.223
   GUR RC, 1992, PSYCHIAT RES, V42, P241, DOI 10.1016/0165-1781(92)90116-K
   Harkness KL, 2005, COGNITION EMOTION, V19, P999, DOI 10.1080/02699930541000110
   Harkness KL, 2010, COGNITION EMOTION, V24, P497, DOI 10.1080/02699930902750249
   Hess U, 1988, FACETS EMOTION RECEN, P161
   HOKANSON JE, 1992, J PERS SOC PSYCHOL, V62, P273, DOI 10.1037/0022-3514.62.2.273
   Joiner T., 1999, INTERACTIONAL NATURE
   JOINER TE, 1993, J SOC CLIN PSYCHOL, V12, P113, DOI 10.1521/jscp.1993.12.2.113
   JOINER TE, 1995, J PERS SOC PSYCHOL, V69, P778, DOI 10.1037//0022-3514.69.4.778
   JOINER TE, 1992, J ABNORM PSYCHOL, V101, P165, DOI 10.1037/0021-843X.101.1.165
   Lee L, 2005, J AFFECT DISORDERS, V86, P247, DOI 10.1016/j.jad.2005.02.007
   Montag C, 2010, J AFFECT DISORDERS, V123, P264, DOI 10.1016/j.jad.2009.08.017
   Murphy FC, 1999, PSYCHOL MED, V29, P1307, DOI 10.1017/S0033291799001233
   Nezlek JB, 2000, J ABNORM PSYCHOL, V109, P11, DOI 10.1037/0021-843X.109.1.11
   PERSAD SM, 1993, J ABNORM PSYCHOL, V102, P358, DOI 10.1037/0021-843X.102.3.358
   RIPPERE V, 1980, BEHAV RES THER, V18, P87, DOI 10.1016/0005-7967(80)90102-3
   Salovey P., 1990, IMAGINATION COGNITIO, V9, P185, DOI DOI 10.2190/DUGG-P24E-52WK-6CDG
   SCHWARTZ GE, 1976, PSYCHOSOM MED, V38, P337
   Sloan DM, 2002, BIOL PSYCHOL, V60, P79, DOI 10.1016/S0301-0511(02)00044-3
   Steer RA, 1999, J CLIN PSYCHOL, V55, P117, DOI 10.1002/(SICI)1097-4679(199901)55:1<117::AID-JCLP12>3.0.CO;2-A
   Surguladze SA, 2004, NEUROPSYCHOLOGY, V18, P212, DOI 10.1037/0894-4105.18.2.212
   Suslow T, 2001, PERCEPT MOTOR SKILL, V92, P857, DOI 10.2466/PMS.92.3.857-868
   Weissman M.M., 1974, DEPRESSED WOMAN STUD
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 36
TC 0
Z9 0
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0736-7236
J9 J SOC CLIN PSYCHOL
JI J. Soc. Clin. Psychol.
PD JAN
PY 2013
VL 32
IS 1
BP 116
EP 133
PG 18
WC Psychology, Clinical; Psychology, Social
SC Psychology
GA 100DA
UT WOS:000315674800007
ER

PT J
AU Kocovska, E
   Billstedt, E
   Ellefsen, A
   Kampmann, H
   Gillberg, IC
   Biskupsto, R
   Andorsdottir, G
   Stora, T
   Minnis, H
   Gillberg, C
AF Kocovska, Eva
   Billstedt, Eva
   Ellefsen, Asa
   Kampmann, Hanna
   Gillberg, I. Carina
   Biskupsto, Rannva
   Andorsdottir, Guorio
   Stora, Tormoour
   Minnis, Helen
   Gillberg, Christopher
TI Autism in the Faroe Islands: Diagnostic Stability from Childhood to
   Early Adult Life
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID SPECTRUM DISORDERS; SCREENING QUESTIONNAIRE; OBSERVATION-SCHEDULE;
   COMMUNICATION DISORDERS; INTERRATER RELIABILITY; PARKINSONS-DISEASE;
   ASPERGER-SYNDROME; TOTAL POPULATION; SCHOOL-AGE; CHILDREN
AB Childhood autism or autism spectrum disorder (ASD) has been regarded as one of the most stable diagnostic categories applied to young children with psychiatric/developmental disorders. The stability over time of a diagnosis of ASD is theoretically interesting and important for various diagnostic and clinical reasons. We studied the diagnostic stability of ASD from childhood to early adulthood in the Faroe Islands: a total school age population sample (8-17-year-olds) was screened and diagnostically assessed for AD in 2002 and 2009. This paper compares both independent clinical diagnosis and Diagnostic Interview for Social and Communication Disorders (DISCO) algorithm diagnosis at two time points, separated by seven years. The stability of clinical ASD diagnosis was perfect for AD, good for "atypical autism"/PDD-NOS, and less than perfect for Asperger syndrome (AS). Stability of the DISCO algorithm subcategory diagnoses was more variable but still good for AD. Both systems showed excellent stability over the seven-year period for "any ASD" diagnosis, although a number of clear cases had been missed at the original screening in 2002. The findings support the notion that subcategories of ASD should be collapsed into one overarching diagnostic entity with subgrouping achieved on other "non-autism" variables, such as IQ and language levels and overall adaptive functioning.
C1 [Kocovska, Eva; Minnis, Helen] Univ Glasgow, Royal Hosp Sick Children, Coll Med Vet & Life Sci, Inst Hlth andWellbeing, Glasgow G3 8SJ, Lanark, Scotland.
   [Billstedt, Eva; Gillberg, I. Carina; Gillberg, Christopher] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gillberg Neuropsychiat Ctr, S-41119 Gothenburg, Sweden.
   [Ellefsen, Asa; Kampmann, Hanna] Sernamsdepilin, Dept Educ Psychol, Torshavn 100, Faroe Islands, Denmark.
   [Biskupsto, Rannva] Natl Hosp Faroe Isl, Dept Psychiat, Torshavn 100, Faroe Islands, Denmark.
   [Andorsdottir, Guorio] Minist Hlth, Genet Biobank Faroes, Torshavn 100, Faroe Islands, Denmark.
   [Stora, Tormoour] Natl Hosp Faroe Isl, Ctr Psychiat, Torshavn 100, Faroe Islands, Denmark.
RP Kocovska, E (reprint author), Univ Glasgow, Royal Hosp Sick Children, Coll Med Vet & Life Sci, Inst Hlth andWellbeing, Caledonia House, Glasgow G3 8SJ, Lanark, Scotland.
EM eva.kocovska@gnc.gu.se
FU Swedish Science Council; Gillberg Neuropsychiatry Centre
FX This work was supported by the Swedish Science Council, a grant under
   the ALF agreement, and the Gillberg Neuropsychiatry Centre.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
   Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x
   Coleman M., 2011, AUTISMS
   Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
   Daniels AM, 2011, J AUTISM DEV DISORD, V41, P110, DOI 10.1007/s10803-010-1031-x
   Ehlers S, 1999, J AUTISM DEV DISORD, V29, P129, DOI 10.1023/A:1023040610384
   EHLERS S, 1993, J CHILD PSYCHOL PSYC, V34, P1327, DOI 10.1111/j.1469-7610.1993.tb02094.x
   Ellefsen A, 2007, J AUTISM DEV DISORD, V37, P437, DOI 10.1007/s10803-006-0178-y
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Gillberg C., 1991, AUTISM ASPERGER SYND, P122, DOI 10.1017/CBO9780511526770.004
   GILLBERG CL, 1992, J CHILD PSYCHOL PSYC, V33, P813, DOI 10.1111/j.1469-7610.1992.tb01959.x
   Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7
   Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P606, DOI 10.1007/s10803-007-0427-8
   Kocovska E, 2012, J AUTISM DEV DISORD, V42, P1959, DOI 10.1007/s10803-012-1444-9
   LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310
   Leekam S. R., 2011, ENCY AUTISM SPECTRUM
   Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144
   Moss J, 2008, J AUTISM DEV DISORD, V38, P1081, DOI 10.1007/s10803-007-0487-9
   Nygren G, 2012, J AUTISM DEV DISORD, V42, P1491, DOI 10.1007/s10803-011-1391-x
   Nygren G, 2009, J AUTISM DEV DISORD, V39, P730, DOI 10.1007/s10803-008-0678-z
   Posserud MB, 2009, J AUTISM DEV DISORD, V39, P126, DOI 10.1007/s10803-008-0609-z
   Posserud MB, 2006, J CHILD PSYCHOL PSYC, V47, P167, DOI 10.1111/j.1469-7610.2005.01462.x
   Rondeau E, 2011, J AUTISM DEV DISORD, V41, P1267, DOI 10.1007/s10803-010-1155-z
   Rutter M., 2003, SOCIAL COMMUNICATION
   SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436
   STEFFENBURG S, 1986, BRIT J PSYCHIAT, V149, P81, DOI 10.1192/bjp.149.1.81
   Swinkels SHN, 2006, J AUTISM DEV DISORD, V36, P723, DOI 10.1007/s10803-006-0115-0
   van Daalen E, 2009, EUR CHILD ADOLES PSY, V18, P663, DOI 10.1007/s00787-009-0025-8
   Wechsler D., 1992, WECHSLER INTELLIGENC
   Wechsler D, 1981, WECHSLER ADULT INTEL
   Wechsler D., 1974, MANUAL WECHSLER INTE
   Wermuth L, 1997, NEUROLOGY, V49, P426
   Wermuth L, 2000, EUR J NEUROL, V7, P655, DOI 10.1046/j.1468-1331.2000.00131.x
   WHO, 1993, ICD 10 CLASS MENT BE
   Wing L., 2001, AUTISTIC SPECTRUM
   Wing L., 1996, CLIN DEV MED, P247
   Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
NR 41
TC 2
Z9 2
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 592371
DI 10.1155/2013/592371
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 097VL
UT WOS:000315501500001
ER

PT J
AU Hadjixenofontos, A
   Schmidt, MA
   Whitehead, PL
   Konidari, I
   Hedges, DJ
   Wright, HH
   Abramson, RK
   Menon, R
   Williams, SM
   Cuccaro, ML
   Haines, JL
   Gilbert, JR
   Pericak-Vance, MA
   Martin, ER
   McCauley, JL
AF Hadjixenofontos, Athena
   Schmidt, Michael A.
   Whitehead, Patrice L.
   Konidari, Ioanna
   Hedges, Dale J.
   Wright, Harry H.
   Abramson, Ruth K.
   Menon, Ramkumar
   Williams, Scott M.
   Cuccaro, Michael L.
   Haines, Jonathan L.
   Gilbert, John R.
   Pericak-Vance, Margaret A.
   Martin, Eden R.
   McCauley, Jacob L.
TI Evaluating Mitochondrial DNA Variation in Autism Spectrum Disorders
SO ANNALS OF HUMAN GENETICS
LA English
DT Article
DE mitochondrial DNA; autism; autism spectrum disorders; association
   studies; genetic
ID CARRIER SLC25A12 GENE; GENOME-WIDE ASSOCIATION; N-ACETYLASPARTATE;
   HUMAN-EVOLUTION; DISEASE; DYSFUNCTION; POPULATION; COMMON; HAPLOGROUPS;
   CHILDREN
AB Despite the increasing speculation that oxidative stress and abnormal energy metabolism may play a role in Autism Spectrum Disorders (ASD), and the observation that patients with mitochondrial defects have symptoms consistent with ASD, there are no comprehensive published studies examining the role of mitochondrial variation in autism. Therefore, we have sought to comprehensively examine the role of mitochondrial DNA (mtDNA) variation with regard to ASD risk, employing a multi-phase approach.
   In phase 1 of our experiment, we examined 132 mtDNA single-nucleotide polymorphisms (SNPs) genotyped as part of our genome-wide association studies of ASD. In phase 2 we genotyped the major European mitochondrial haplogroup-defining variants within an expanded set of autism probands and controls. Finally in phase 3, we resequenced the entire mtDNA in a subset of our Caucasian samples (similar to 400 proband-father pairs). In each phase we tested whether mitochondrial variation showed evidence of association to ASD. Despite a thorough interrogation of mtDNA variation, we found no evidence to suggest a major role for mtDNA variation in ASD susceptibility. Accordingly, while there may be attractive biological hints suggesting the role of mitochondria in ASD our data indicate that mtDNA variation is not a major contributing factor to the development of ASD.
C1 [Hadjixenofontos, Athena; Schmidt, Michael A.; Whitehead, Patrice L.; Konidari, Ioanna; Hedges, Dale J.; Cuccaro, Michael L.; Gilbert, John R.; Pericak-Vance, Margaret A.; Martin, Eden R.; McCauley, Jacob L.] Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA.
   [Wright, Harry H.; Abramson, Ruth K.] Univ S Carolina, Sch Med, Columbia, SC USA.
   [Menon, Ramkumar] Univ Texas Med Branch, Galveston, TX 77555 USA.
   [Williams, Scott M.] Vanderbilt Univ, Dept Mol Physiol & Biophys, Ctr Human Genet Res, Nashville, TN 37232 USA.
   [Haines, Jonathan L.] Vanderbilt Univ, Med Ctr, Ctr Human Genet Res, Nashville, TN USA.
RP McCauley, JL (reprint author), Univ Miami, Miller Sch Med, Hussman Inst Human Genom, 1501 NW 10th Ave,BRB 307,M 860, Miami, FL 33136 USA.
EM jmccauley@med.miami.edu
RI Williams, Scott/B-9491-2012; Haines, Jonathan/C-3374-2012
FU NIMH [1U24MH081810]; Massachusetts General Hospital [MH 63420]; National
   Institutes of Health [9R01MH080647, 7P01NS026630]
FX We thank the autism patients and their families, as well as the control
   parents and children for their participation in our studies. This work
   would not be possible without their generosity. We gratefully
   acknowledge the resources provided by the AGRE Consortium and the
   participating AGRE families. The AGRE is a program of Autism Speaks and
   is supported in part, by grant 1U24MH081810 from the NIMH to Clara M.
   Lajonchere (PI). We thank the individuals who volunteered for the
   control sample for their participation. A number of control subjects
   came from the National Institute of Mental Health Schizophrenia Genetics
   Initiative (NIMH-GI), data and biomaterials were collected by the
   "Molecular Genetics of Schizophrenia II" (MGS-2) collaboration. The
   investigators and co-investigators are: ENH/Northwestern University,
   Evanston, IL, MH059571, Pablo V. Gejman, M.D. (Collaboration
   Coordinator; PI), Alan R. Sanders, M. D.; Emory University School of
   Medicine, Atlanta GA, MH59587, Farooq Amin, M. D. (PI); Louisiana State
   University Health Sciences Center; New Orleans, Louisiana, MH067257,
   Nancy Buccola APRN, BC, MSN (PI); University of California-Irvine,
   Irvine, CA, MH60870, William Byerley, M. D. (PI); Washington University,
   St. Louis, MO, U01, MH060879, C. Robert Cloninger, M. D. (PI);
   University of Iowa, Iowa City, IA, MH59566, Raymond Crowe, M. D. (PI),
   Donald Black, M. D.; University of Colorado, Denver, CO, MH059565,
   Robert Freedman, M. D. (PI); University of Pennsylvania, Philadelphia,
   PA, MH061675, Douglas Levinson, M. D. (PI); University of Queensland,
   Queensland, Australia, MH059588, Bryan Mowry, M. D. (PI); Mt. Sinai
   School of Medicine, New York, NY, MH59586, Jeremy Silverman, Ph.D. (PI).
   In addition, cord blood samples were collected by V L Nimgaonkar's group
   at the University of Pittsburgh, as part of a multi-institutional
   collaborative research project with J Smoller, M. D. D. Sc. and P Sklar,
   M. D. Ph.D. (Massachusetts General Hospital) (grant MH 63420).We are
   grateful to the John P. Hussman Institute for Human Genomics (HIHG)
   personnel within the Patient and Family Ascertainment Core, the
   Biorepository, and the Center for Genome Technology for their commitment
   to this project. This research was supported by grants from the National
   Institutes of Health (9R01MH080647 and 7P01NS026630) and by a gift from
   the Hussman Foundation. A subset of the participants was ascertained
   while Dr. Pericak-Vance was a faculty member at Duke University.
CR Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307
   Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x
   Biffi A, 2010, AM J HUM GENET, V86, P904, DOI 10.1016/j.ajhg.2010.05.005
   Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x
   Blasi F, 2006, EUR J HUM GENET, V14, P123, DOI 10.1038/sj.ejhg.5201444
   Canter JA, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002091
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   CHEN YS, 1995, AM J HUM GENET, V57, P133
   Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9
   Clark-Taylor T, 2004, MED HYPOTHESES, V62, P970, DOI 10.1016/j.mehy.2004.01.011
   Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
   Coon KD, 2006, MITOCHONDRION, V6, P194, DOI 10.1016/j.mito.2006.07.002
   Correia C, 2006, J AUTISM DEV DISORD, V36, P1137, DOI 10.1007/s10803-006-0138-6
   Cutler DJ, 2001, GENOME RES, V11, P1913
   De Zwart LL, 1999, FREE RADICAL BIO MED, V26, P202, DOI 10.1016/S0891-5849(98)00196-8
   FEIG DI, 1994, CANCER RES, V54, pS1890
   Filipek PA, 2003, ANN NEUROL, V53, P801, DOI 10.1002/ana.10596
   Fillano James J, 2002, J Child Neurol, V17, P435
   FOLSTEIN SE, 1991, PEDIATRICS, V87, P767
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Fombonne E, 2002, MOL PSYCHIATR, V7, pS4, DOI 10.1038/sj.mp.4001162
   Grady Benjamin J, 2010, Pac Symp Biocomput, P315
   Graf WD, 2000, J CHILD NEUROL, V15, P357, DOI 10.1177/088307380001500601
   Griswold AJ, 2012, HUM MOL GENET, V21, P3513, DOI 10.1093/hmg/dds164
   Howell N, 2005, TRENDS GENET, V21, P583, DOI 10.1016/j.tig.2005.08.012
   Kang D, 2003, CLIN CHEM LAB MED, V41, P1281, DOI 10.1515/CCLM.2003.195
   Kent L, 2008, AM J MED GENET B, V147B, P987, DOI 10.1002/ajmg.b.30687
   Kinnamon D. D., 2010, RVASSOC RARE VARIANT
   Kinnamon DD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030238
   Lerman-Sagie T, 2004, J CHILD NEUROL, V19, P379, DOI 10.1177/088307380401900510
   Lombard J, 1998, MED HYPOTHESES, V50, P497, DOI 10.1016/S0306-9877(98)90270-5
   Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x
   Oliveira G, 2005, DEV MED CHILD NEUROL, V47, P185, DOI 10.1017/S0012162205000332
   Otsuka H, 1999, NEURORADIOLOGY, V41, P517
   Pan JW, 2005, ANN NEUROL, V57, P92, DOI 10.1002/ana.20317
   Papa S, 1996, BBA-BIOENERGETICS, V1276, P87, DOI 10.1016/0005-2728(96)00077-1
   Penta JS, 2001, MUTAT RES-REV MUTAT, V488, P119, DOI 10.1016/S1383-5742(01)00053-9
   Poling JS, 2006, J CHILD NEUROL, V21, P170, DOI 10.2310/7010.2006.00032
   Pons R, 2004, J PEDIATR-US, V144, P81, DOI 10.1016/j.jpeds.2003.10.023
   Price AL, 2006, NAT GENET, V38, P904, DOI 10.1038/ng1847
   Pritchard JK, 2000, GENETICS, V155, P945
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Rabionet Raquel, 2006, Am J Psychiatry, V163, P929, DOI 10.1176/appi.ajp.163.5.929
   Ramoz N, 2004, AM J PSYCHIAT, V161, P662, DOI 10.1176/appi.ajp.161.4.662
   Raule N, 2007, MITOCHONDRION, V7, P29, DOI 10.1016/j.mito.2006.11.013
   RITVO ER, 1985, AM J PSYCHIAT, V142, P74
   Rollins B, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004913
   Rossignol Daniel A, 2007, BMC Pediatr, V7, P36, DOI 10.1186/1471-2431-7-36
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Rutter M., 2003, SOCIAL COMMUNICATION
   Salyakina D, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026049
   Samuels DC, 2006, AM J HUM GENET, V78, P713, DOI 10.1086/502682
   Satrustegui J, 2007, J NEUROSCI RES, V85, P3359, DOI 10.1002/jnr.21299
   Scheffler IE, 2001, ADV DRUG DELIVER REV, V49, P3, DOI 10.1016/S0169-409X(01)00123-5
   Segurado R, 2005, AM J PSYCHIAT, V162, P2182, DOI 10.1176/appi.ajp.162.11.2182
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Sparrow SS, 2005, VINELAND ADAPTIVE BE
   Swerdlow RH, 1996, ANN NEUROL, V40, P663, DOI 10.1002/ana.410400417
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   TORRONI A, 1994, AM J HUM GENET, V55, P760
   TSAI GC, 1995, PROG NEUROBIOL, V46, P531, DOI 10.1016/0301-0082(95)00014-M
   Tsao CY, 2007, J CHILD NEUROL, V22, P1121, DOI 10.1177/0883073807306266
   van der Walt JM, 2003, AM J HUM GENET, V72, P804, DOI 10.1086/373937
   Wallace DC, 2005, ANNU REV GENET, V39, P359, DOI 10.1146/annurev.genet.39.110304.095751
   Wallace DC, 1999, GENE, V238, P211, DOI 10.1016/S0378-1119(99)00295-4
   Wallace DC, 1997, SCI AM, V277, P40
   WALLACE DC, 1994, P NATL ACAD SCI USA, V91, P8739, DOI 10.1073/pnas.91.19.8739
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490
NR 71
TC 5
Z9 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0003-4800
J9 ANN HUM GENET
JI Ann. Hum. Genet.
PD JAN
PY 2013
VL 77
BP 9
EP 21
DI 10.1111/j.1469-1809.2012.00736.x
PN 1
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA 093MU
UT WOS:000315196800002
PM 23130936
ER

PT J
AU Hendy, HM
   Seiverling, L
   Lukens, CT
   Williams, KE
AF Hendy, Helen M.
   Seiverling, Laura
   Lukens, Colleen T.
   Williams, Keith E.
TI Brief Assessment of Mealtime Behavior in Children: Psychometrics and
   Association With Child Characteristics and Parent Responses
SO CHILDRENS HEALTH CARE
LA English
DT Article
ID FEEDING PRACTICES; WEIGHT STATUS; QUESTIONNAIRE; ADIPOSITY; INVENTORY;
   EXPOSURE; AUTISM; DIET
AB The present study examined psychometric properties of the Brief Autism Mealtime Behavior Inventory (BAMBI) when applied to a population of children with feeding problems. The new scale was renamed the Brief Assessment of Mealtime Behavior in Children (BAMBIC) for wider clinical usefulness. Parents completed questionnaires with the original BAMBI, the Child Eating Behavior Questionnaire, and the Parent Mealtime Action Scale. The revised BAMBIC developed with factor analysis had stronger psychometrics than the original scale and produced three subscales of feeding problems: Limited Variety, Food Refusal, and Disruptive Behavior. More Limited Variety was reported for boys than girls, and more Food Refusal was reported for younger children and children with special needs.
C1 [Hendy, Helen M.] Psychol Program, Schuylkill Haven, PA USA.
   [Seiverling, Laura] St Marys Hosp Children, Ctr Pediat Feeding Disorders, Bayside, NY USA.
   [Lukens, Colleen T.] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat & Behav Sci, Philadelphia, PA 19104 USA.
   [Williams, Keith E.] Penn State Hershey Med Ctr, Feeding Program, Hershey, PA 17033 USA.
RP Williams, KE (reprint author), Feeding Program, 905 W Governor Rd, Hershey, PA 17033 USA.
EM Feedingprogram@hmc.psu.edu
CR Arbuckle JL, 2007, AMOS 16 0 USERS GUID
   ARCHER LA, 1991, J PEDIATR PSYCHOL, V16, P629, DOI 10.1093/jpepsy/16.5.629
   Birch LL, 2001, APPETITE, V36, P201, DOI 10.1006/appe.2001.0398
   BIRCH LL, 1987, APPETITE, V9, P171, DOI 10.1016/S0195-6663(87)80011-9
   Centers for Disease Control and Prevention, 2000, SCH HLTH IND PHYS AC
   Crist W, 2001, J DEV BEHAV PEDIATR, V22, P279
   Faith MS, 2004, OBES RES, V12, P1711, DOI 10.1038/oby.2004.212
   Field D, 2003, J PAEDIATR CHILD H, V39, P299, DOI 10.1046/j.1440-1754.2003.00151.x
   Grimmett C., 2008, PEDIATRICS, V122, P682
   Hendy HM, 2009, APPETITE, V52, P328, DOI 10.1016/j.appet.2008.11.003
   Hendy HM, 2010, APPETITE, V54, P191, DOI 10.1016/j.appet.2009.10.006
   Hughes SO, 2008, J DEV BEHAV PEDIATR, V29, P403, DOI 10.1097/DBP.0b013e318182a976
   JANZ NK, 1984, HEALTH EDUC QUART, V11, P1, DOI 10.1177/109019818401100101
   Kerwin ME, 1999, J PEDIATR PSYCHOL, V24, P193, DOI 10.1093/jpepsy/24.3.193
   Linscheid TR, 2006, BEHAV MODIF, V30, P6, DOI 10.1177/0145445505282165
   Lukens CT, 2008, J AUTISM DEV DISORD, V38, P342, DOI 10.1007/s10803-007-0401-5
   Manikam S., 2000, J CLIN GASTROENTEROL, V30, P34
   Rhoe K. E., 2006, PEDIATRICS, V117, P2047
   Schreck KA, 2004, J AUTISM DEV DISORD, V34, P433, DOI 10.1023/B:JADD.0000037419.78531.86
   Sleddens EFC, 2008, INT J BEHAV NUTR PHY, V5, DOI 10.1186/1479-5868-5-49
   Spruijt-Metz D, 2002, AM J CLIN NUTR, V75, P581
   Ventura AK, 2008, INT J BEHAV NUTR PHY, V5, DOI 10.1186/1479-5868-5-15
   Wardle J, 2001, J CHILD PSYCHOL PSYC, V42, P963, DOI 10.1111/1469-7610.00792
   Wardle J, 2003, EUR J CLIN NUTR, V57, P341, DOI 10.1038/sj.ejcn.1601541
   Webber L, 2010, AM J CLIN NUTR, V92, P1423, DOI 10.3945/ajcn.2010.30112
   Williams KE, 2011, APPETITE, V56, P553, DOI 10.1016/j.appet.2011.01.021
   Williams KE, 2008, J DEV PHYS DISABIL, V20, P231, DOI 10.1007/s10882-007-9091-3
NR 27
TC 1
Z9 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0273-9615
J9 CHILD HEALTH CARE
JI Child. Health Care
PD JAN 1
PY 2013
VL 42
IS 1
BP 1
EP 14
DI 10.1080/02739615.2013.753799
PG 14
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 095OQ
UT WOS:000315344300001
ER

PT J
AU Lerner, MD
   McPartland, JC
   Morris, JP
AF Lerner, Matthew D.
   McPartland, James C.
   Morris, James P.
TI Multimodal emotion processing in autism spectrum disorders: An
   event-related potential study
SO DEVELOPMENTAL COGNITIVE NEUROSCIENCE
LA English
DT Article
DE Autism spectrum disorder; ERP; N170; Emotion processing; Emotion
   recognition; Social cognition
ID FACIAL AFFECT RECOGNITION; HIGH-FUNCTIONING AUTISM; ASPERGERS-SYNDROME;
   SCHIZOPHRENIC-PATIENTS; FACE RECOGNITION; CHILDREN; ERP; PERCEPTION;
   BRAIN; EXPRESSIONS
AB This study sought to describe heterogeneity in emotion processing in autism spectrum disorders (ASD) via electrophysiological markers of perceptual and cognitive processes that underpin emotion recognition across perceptual modalities. Behavioral and neural indicators of emotion processing were collected, as event-related potentials (ERPs) were recorded while youth with ASD completed a standardized facial and vocal emotion identification task. Children with ASD exhibited impaired emotion recognition performance for adult faces and child voices, with a subgroup displaying intact recognition. Latencies of early perceptual ERP components, marking social information processing speed, and amplitudes of subsequent components reflecting emotion evaluation, each correlated across modalities. Social information processing speed correlated with emotion recognition performance, and predicted membership in a subgroup with intact adult vocal emotion recognition. Results indicate that the essential multimodality of emotion recognition in individuals with ASDs may derive from early social information processing speed, despite heterogeneous behavioral performance; this process represents a novel social-emotional intervention target for ASD. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Lerner, Matthew D.; Morris, James P.] Univ Virginia, Dept Psychol, Charlottesville, VA 22904 USA.
   [Lerner, Matthew D.] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA.
   [McPartland, James C.] Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
RP Lerner, MD (reprint author), Univ Virginia, Dept Psychol, 102 Gilmer Hall,POB 400400, Charlottesville, VA 22904 USA.
EM mlerner@virginia.edu; james.mcpartland@yale.edu; jpmorris@virginia.edu
FU American Psychological Foundation; Jefferson Scholars Foundation;
   International Max Planck Research School; American Psychological
   Association and Association for Psychological Science; NIMH
   [R00MH079617-03, K23MH086785, R21MH091309]; NARSAD Atherton Young
   Investigator Award
FX This research was supported by Fellowships from the American
   Psychological Foundation, Jefferson Scholars Foundation, and
   International Max Planck Research School, and grants from the American
   Psychological Association and Association for Psychological Science to
   Matthew D. Lerner, and NIMH grant R00MH079617-03 to James P. Morris.
   James C. McPartland was supported by NIMH K23MH086785, NIMH R21MH091309
   and a NARSAD Atherton Young Investigator Award. Portions of this article
   were presented at the 2011 American Academy of Child and Adolescent
   Psychiatry/Canadian Academy of Child and Adolescent Psychiatry Joint
   Annual Meeting. We would like to thank the children and parents who
   participated, as well as the research assistants who aided with data
   collection.
CR Baker KF, 2010, J AUTISM DEV DISORD, V40, P123, DOI 10.1007/s10803-009-0841-1
   Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3
   Balconi M, 2008, INT J NEUROSCI, V118, P1412, DOI 10.1080/00207450601047119
   Batty M, 2011, J EXP CHILD PSYCHOL, V109, P430, DOI 10.1016/j.jecp.2011.02.001
   Batty M, 2006, DEVELOPMENTAL SCI, V9, P207, DOI 10.1111/j.1467-7687.2006.00480.x
   Baum K., 1996, M SOC RES PERS ATL G
   Beauchamp MH, 2010, PSYCHOL BULL, V136, P39, DOI 10.1037/a0017768
   Bentin S, 1996, J COGNITIVE NEUROSCI, V8, P551, DOI 10.1162/jocn.1996.8.6.551
   Blau V., 2007, BEHAV BRAIN FUNCT, V3, P1, DOI DOI 10.1186/1744-9081-3-7
   Borod JC, 2000, COGNITION EMOTION, V14, P193
   BOWLER DM, 1992, J CHILD PSYCHOL PSYC, V33, P877, DOI 10.1111/j.1469-7610.1992.tb01962.x
   Carretie L, 2001, J COGNITIVE NEUROSCI, V13, P1109, DOI 10.1162/089892901753294400
   Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991
   Chevallier C., 2012, TRENDS COGNITIVE SCI
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   DAWSON G, 1988, J AUTISM DEV DISORD, V18, P493, DOI 10.1007/BF02211869
   Demertzis A., 1998, CORRELATES ABILITY R
   Dissanayake C., 2003, MIND READING SOCIAL, P213
   Eimer M, 2003, COGN AFFECT BEHAV NE, V3, P97, DOI 10.3758/CABN.3.2.97
   Faja S, 2012, J AUTISM DEV DISORD, V42, P278, DOI 10.1007/s10803-011-1243-8
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Hileman CM, 2011, DEV NEUROPSYCHOL, V36, P214, DOI 10.1080/87565641.2010.549870
   Itier RJ, 2004, NEUROREPORT, V15, P1261, DOI 10.1097/01.wnr.0000127827.3576.d8
   JACOBSON NS, 1991, J CONSULT CLIN PSYCH, V59, P12, DOI 10.1037//0022-006X.59.1.12
   Jeste SS, 2009, J AUTISM DEV DISORD, V39, P495, DOI 10.1007/s10803-008-0652-9
   Jones CRG, 2010, J CHILD PSYCHOL PSYC, V52, P275, DOI DOI 10.1111/J.1469-7610.2010.02328.X
   Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344
   Key APF, 2005, DEV NEUROPSYCHOL, V27, P183, DOI 10.1207/s15326942dn2702_1
   Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868
   Lerner Matthew D, 2012, Dialogues Clin Neurosci, V14, P307
   Lerner MD, 2011, AUTISM, V15, P21, DOI 10.1177/1362361309353613
   Lord C., 1999, MANUAL AUTISM DIAGNO
   Luo WB, 2010, NEUROIMAGE, V49, P1857, DOI 10.1016/j.neuroimage.2009.09.018
   McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x
   McPartland JC, 2011, SOC NEUROSCI-UK, V6, P436, DOI 10.1080/17470919.2011.586880
   Nelson CA, 2008, J AM ACAD CHILD PSY, V47, P1252, DOI 10.1097/CHI.0b013e318185a6d8
   Nowicki Jr. S., 2004, MANUAL RECEPTIVE TES
   NOWICKI S, 1993, J SOC PSYCHOL, V133, P749
   O'Connor K, 2007, INT J PSYCHOPHYSIOL, V63, P283, DOI 10.1016/j.ijpsycho.2006.12.001
   O'Connor K, 2005, BRAIN COGNITION, V59, P82, DOI 10.1016/j.bandc.2005.05.004
   Paulmann S, 2008, BRAIN LANG, V105, P59, DOI 10.1016/j.bandl.2007.11.005
   Paulmann S, 2010, SOC NEUROSCI-UK, V5, P59, DOI 10.1080/17470910903135668
   Paulmann S, 2009, J PSYCHOPHYSIOL, V23, P63, DOI 10.1027/0269-8803.23.2.63
   Paulmann S, 2008, NEUROREPORT, V19, P209, DOI 10.1097/WNR.0b013e3282f454db
   Pelphrey KA, 2007, SOC COGN AFFECT NEUR, V2, P140, DOI 10.1093/scan/nsm010
   Philip RCM, 2010, PSYCHOL MED, V40, P1919, DOI 10.1017/S0033291709992364
   Pinheiro A.P., 2010, RES DEV DISABIL, V32, P133
   Riby DM, 2009, J AUTISM DEV DISORD, V39, P421, DOI 10.1007/s10803-008-0641-z
   Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x
   Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7
   Ryan JJ, 2007, J CLIN PSYCHOL, V63, P309, DOI 10.1002/jclp.20343
   Shibata T, 2002, BRAIN TOPOGR, V15, P51, DOI 10.1023/A:1019944607316
   Solomon M, 2004, J AUTISM DEV DISORD, V34, P649, DOI 10.1007/s10803-004-5286-y
   Streit M, 2003, SCHIZOPHR RES, V61, P121, DOI 10.1016/S0920-9964(02)00301-8
   Streit M, 1999, COGNITIVE BRAIN RES, V7, P481, DOI 10.1016/S0926-6410(98)00048-2
   Streit M, 2001, SCHIZOPHR RES, V49, P145, DOI 10.1016/S0920-9964(00)00041-4
   Webb SJ, 2006, J AUTISM DEV DISORD, V36, P881, DOI 10.1007/s10803-006-0126-x
   Webb SJ, 2011, CHILD DEV, V82, P1868, DOI 10.1111/j.1467-8624.2011.01656.x
   Webb SJ, 2010, INT J PSYCHOPHYSIOL, V77, P106, DOI 10.1016/j.ijpsycho.2010.04.011
   Wechsler D., 2003, MANUAL WECHSLER INTE, VFourth
   Whitehouse AJO, 2008, DEVELOPMENTAL SCI, V11, P516, DOI 10.1111/j.1467-7687.2008.00697.x
   Wicker B, 2008, SOC COGN AFFECT NEUR, V3, P135, DOI 10.1093/scan/nsn007
   Wong TKW, 2008, EUR J NEUROSCI, V28, P407, DOI 10.1111/j.1460-9568.2008.06328.x
   Wynn JK, 2008, SCHIZOPHRENIA BULL, V34, P679, DOI 10.1093/schbul/sbn047
NR 64
TC 6
Z9 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1878-9293
J9 DEV COGN NEUROS-NETH
JI Dev. Cogn. Neurosci.
PY 2013
VL 3
BP 11
EP 21
DI 10.1016/j.dcn.2012.08.005
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 095EU
UT WOS:000315318300002
PM 23245216
ER

PT J
AU Michalska, KJ
   Kinzler, KD
   Decety, J
AF Michalska, Kalina J.
   Kinzler, Katherine D.
   Decety, Jean
TI Age-related sex differences in explicit measures of empathy do not
   predict brain responses across childhood and adolescence
SO DEVELOPMENTAL COGNITIVE NEUROSCIENCE
LA English
DT Article
DE Developmental neuroscience; Affective neuroscience; Empathy; Sex
   differences
ID HIGH-FUNCTIONING AUTISM; GENDER-DIFFERENCES; FETAL TESTOSTERONE;
   INDIVIDUAL-DIFFERENCES; UNDERLYING EMPATHY; ASPERGER-SYNDROME; EYES
   TEST; PAIN; ACCURACY; OTHERS
AB Behavioral research indicates that human females are more empathic than males, a disparity that widens from childhood to adulthood. Nevertheless, the extent to which such sex differences are an artifact of self-report indices is unclear. The present study compared age-related sex differences in both self-report and neurophysiological measures of empathic arousal, a primary building block of empathy. Participants included sixty-five 4-17-year-old children (mean 11.5 +/- 3.5 years) who completed the Bryant Empathy Scale, and were scanned while viewing animated clips depicting people being hurt. Female participants scored higher than males on self-reported dispositional empathy, a difference that increased with age. In contrast, no sex-related differential changes were detected in hemodynamic responses or in pupil dilation, with no interaction between sex and age. Results suggest a dissociation between explicit ratings and neurophysiological measures of empathic arousal. Past observed sex differences in empathy may reflect females' greater willingness to report empathic experiences. Findings are also discussed in terms of discrepancies in the methods used to assess affective responding and how they relate to the multi-faceted construct of empathy. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Michalska, Kalina J.; Kinzler, Katherine D.; Decety, Jean] Univ Chicago, Dept Psychol, Chicago, IL 60637 USA.
   [Decety, Jean] Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA.
RP Michalska, KJ (reprint author), Univ Chicago, Dept Psychol, Chicago, IL 60637 USA.
EM kalina@uchicago.edu
FU NSF [BCS-0718480]
FX The study was supported by an NSF award (BCS-0718480) to jean Decety. We
   are grateful to Alexa Tompary for assistance in scanning and data
   analysis. We thank three anonymous reviewers for their constructive
   comments.
CR Akitsuki Y, 2009, NEUROIMAGE, V47, P722, DOI 10.1016/j.neuroimage.2009.04.091
   Andersen S., 2012, REV EC STAT
   Bandstra NF, 2011, PAIN, V152, P1074, DOI 10.1016/j.pain.2011.01.024
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Batson CD, 2011, ALTRUISM HUMANS
   BRYANT BK, 1982, CHILD DEV, V53, P413, DOI 10.1111/j.1467-8624.1982.tb01331.x
   Chapman E, 2006, SOC NEUROSCI, V1, P135, DOI 10.1080/17470910600992239
   Cheng YW, 2010, NEUROIMAGE, V51, P923, DOI 10.1016/j.neuroimage.2010.02.047
   CIALDINI RB, 1987, J PERS SOC PSYCHOL, V52, P749, DOI 10.1037/0022-3514.52.4.749
   Cohen D, 1996, DEV PSYCHOL, V32, P988, DOI 10.1037//0012-1649.32.6.988
   Coll MP, 2012, J PAIN, V13, P695, DOI 10.1016/j.jpain.2012.04.009
   DAVIS MH, 1991, J RES PERS, V25, P70, DOI 10.1016/0092-6566(91)90006-C
   DAVIS MH, 1983, J PERS SOC PSYCHOL, V44, P113, DOI 10.1037//0022-3514.44.1.113
   Decety J, 2010, DEVELOPMENTAL SCI, V13, P886, DOI 10.1111/j.1467-7687.2009.00940.x
   Decety J, 2011, EMOT REV, V3, P92, DOI 10.1177/1754073910374662
   Decety J, 2012, DEV COGN NEUROS-NETH, V2, P1, DOI 10.1016/j.dcn.2011.05.003
   Decety J, 2012, CEREB CORTEX, V22, P209, DOI 10.1093/cercor/bhr111
   Decety J, 2008, NEUROPSYCHOLOGIA, V46, P2607, DOI 10.1016/j.neuropsychologia.2008.05.026
   Decety J, 2011, NEUROPSYCHOLOGIA, V49, P2994, DOI 10.1016/j.neuropsychologia.2011.06.024
   Decety J, 2010, DEV NEUROSCI-BASEL, V32, P257, DOI 10.1159/000317771
   Decety J, 2012, PROG NEUROBIOL, V98, P38, DOI 10.1016/j.pneurobio.2012.05.001
   Decety J, 2009, BIOL PSYCHOL, V80, P203, DOI 10.1016/j.biopsycho.2008.09.004
   Derntl B, 2010, PSYCHONEUROENDOCRINO, V35, P67, DOI 10.1016/j.psyneuen.2009.10.006
   de Wied M, 2007, EUR J PSYCHOL ASSESS, V23, P99, DOI 10.1027/1015-5759.23.2.99
   EISENBERG N, 1991, DEV PSYCHOL, V27, P849, DOI 10.1037/0012-1649.27.5.849
   Eisenberg N., 1989, NEW DIR CHILD ADOLES, V44, P107, DOI DOI 10.1002/CD.23219894408
   EISENBERG N, 1983, PSYCHOL BULL, V94, P100, DOI 10.1037/0033-2909.94.1.100
   Geangu E, 2010, INFANT BEHAV DEV, V33, P279, DOI 10.1016/j.infbeh.2010.03.004
   Geary D. C., 2002, BIOL SOC BEHAV DEV S, P23
   Glascher J, 2009, NEUROINFORMATICS, V7, P73, DOI 10.1007/s12021-008-9042-x
   Gu XS, 2010, J NEUROSCI, V30, P3739, DOI 10.1523/JNEUROSCI.4844-09.2010
   HALL JA, 1978, PSYCHOL BULL, V85, P845, DOI 10.1037//0033-2909.85.4.845
   Hall JA, 2007, EMOTION, V7, P438, DOI 10.1037/1528-3542.7.2.438
   Hancock M, 1996, J SOC PERS RELAT, V13, P179, DOI 10.1177/0265407596132002
   Hempel J., 2009, THESIS U CHICAGO
   Ickes W, 2000, PERS RELATIONSHIP, V7, P95, DOI 10.1111/j.1475-6811.2000.tb00006.x
   ICKES W, 1990, J PERS SOC PSYCHOL, V59, P730, DOI 10.1037//0022-3514.59.4.730
   Jackson PL, 2005, NEUROIMAGE, V24, P771, DOI 10.1016/j.neuroimage.2004.09.006
   Jackson PL, 2006, PAIN, V125, P5, DOI 10.1016/j.pain.2006.09.013
   Karniol R, 1998, SEX ROLES, V39, P45, DOI 10.1023/A:1018825732154
   Killgore WDS, 1999, PERCEPT MOTOR SKILL, V89, P311, DOI 10.2466/PMS.89.5.311-314
   Killgore WDS, 2001, NEUROREPORT, V12, P427, DOI 10.1097/00001756-200102120-00047
   Killgore WDS, 2000, PERCEPT MOTOR SKILL, V91, P525, DOI 10.2466/PMS.91.6.525-530
   Klein KJK, 2001, PERS SOC PSYCHOL B, V27, P720, DOI 10.1177/0146167201276007
   Knafo A, 2008, EMOTION, V8, P737, DOI 10.1037/a0014179
   Knickmeyer R, 2006, HORM BEHAV, V49, P282, DOI 10.1016/j.yhbeh.2005.08.010
   Knickmeyer R, 2005, J CHILD PSYCHOL PSYC, V46, P198, DOI 10.1111/j.1469-7610.2004.00349.x
   Krendl AC, 2008, PSYCHOL SCI, V19, P168, DOI 10.1111/j.1467-9280.2008.02063.x
   Lamm C, 2007, J COGNITIVE NEUROSCI, V19, P42, DOI 10.1162/jocn.2007.19.1.42
   Lamm C, 2010, J COGNITIVE NEUROSCI, V22, P362, DOI 10.1162/jocn.2009.21186
   Lamm C, 2011, NEUROIMAGE, V54, P2492, DOI 10.1016/j.neuroimage.2010.10.014
   Lamm C., 2007, PLOS ONE, V12, pe1292
   Legrain V, 2011, PROG NEUROBIOL, V93, P111, DOI 10.1016/j.pneurobio.2010.10.005
   Lennon R., 1987, EMPATHY ITS DEV, P195
   Mangels JA, 2012, SOC COGN AFFECT NEUR, V7, P230, DOI 10.1093/scan/nsq100
   MARANGONI C, 1995, J PERS SOC PSYCHOL, V68, P854, DOI 10.1037//0022-3514.68.5.854
   Massa LJ, 2005, LEARN INDIVID DIFFER, V15, P99, DOI 10.1016/j.lindif.2004.11.002
   McClure EB, 2000, PSYCHOL BULL, V126, P424, DOI 10.1037/0033-2909.126.3.424
   Mogil JS, 2010, PROG BRAIN RES, V186, P141, DOI 10.1016/B978-0-444-53630-3.00009-9
   Moriguchi Y, 2007, CEREB CORTEX, V17, P2223, DOI 10.1093/cercor/bhl130
   Otti A, 2010, NEUROSCIENCE, V169, P143, DOI 10.1016/j.neuroscience.2010.04.072
   Paulson PE, 1998, PAIN, V76, P223, DOI 10.1016/S0304-3959(98)00048-7
   Roth-Hanania R, 2011, INFANT BEHAV DEV, V34, P447, DOI 10.1016/j.infbeh.2011.04.007
   Rueckert L, 2008, BRAIN COGNITION, V67, P162, DOI 10.1016/j.bandc.2008.01.002
   Schulte-Ruther H.J., 2008, NEUROIMAGE, V42, P393
   Singer T, 2006, NATURE, V439, P466, DOI 10.1038/nature04271
   Singer T, 2009, ANN NY ACAD SCI, V1156, P81, DOI 10.1111/j.1749-6632.2009.04418.x
   van Honka J, 2011, P NATL ACAD SCI USA, V108, P3448, DOI 10.1073/pnas.1011891108
   Van Essen DC, 2005, NEUROIMAGE, V28, P635, DOI 10.1016/j.neuroimage.2005.06.058
   Wager TD, 2005, NEUROREPORT, V16, P85, DOI 10.1097/00001756-200502080-00001
   Wager TD, 2003, NEUROIMAGE, V19, P513, DOI 10.1016/S1053-8199(03)00078-8
   Yamada M, 2009, PAIN, V143, P71, DOI 10.1016/j.pain.2009.01.028
   ZARBATANY L, 1985, DEV PSYCHOL, V21, P97, DOI 10.1037//0012-1649.21.1.97
NR 74
TC 12
Z9 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1878-9293
J9 DEV COGN NEUROS-NETH
JI Dev. Cogn. Neurosci.
PY 2013
VL 3
BP 22
EP 32
DI 10.1016/j.dcn.2012.08.001
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 095EU
UT WOS:000315318300003
PM 23245217
ER

PT J
AU Hamilton, AFD
AF Hamilton, Antonia F. de C.
TI Reflecting on the mirror neuron system in autism: A systematic review of
   current theories
SO DEVELOPMENTAL COGNITIVE NEUROSCIENCE
LA English
DT Review
DE Autism; Mirror neuron system; Imitation; Social cognition
ID SPECTRUM DISORDERS; MAGNETIC STIMULATION; CORTICAL ACTIVATION; MOTOR
   FACILITATION; SOCIAL-INTERACTION; ALE METAANALYSIS; STRUCTURAL MRI;
   MU-SUPPRESSION; IMITATION; CHILDREN
AB There is much interest in the claim that dysfunction of the mirror neuron system in individuals with autism spectrum condition causes difficulties in social interaction and communication. This paper systematically reviews all published studies using neuroscience methods (EEG/MEG/TMS/eyetracking/EMG/fMRI) to examine the integrity of the mirror system in autism. 25 suitable papers are reviewed. The review shows that current data are very mixed and that studies using weakly localised measures of the integrity of the mirror system are hard to interpret. The only well localised measure of mirror system function is fMRI. In fMRI studies, those using emotional stimuli have reported group differences, but studies using non-emotional hand action stimuli do not. Overall, there is little evidence for a global dysfunction of the mirror system in autism. Current data can be better understood under an alternative model in which social top-down response modulation is abnormal in autism. The implications of this model and future research directions are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
C1 Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
RP Hamilton, AFD (reprint author), Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
EM antonia.hamilton@nottingham.ac.uk
RI Hamilton, Antonia/B-3612-2008
OI Hamilton, Antonia/0000-0001-8000-0219
FU Waterloo Foundation; ESRC
FX The Hamilton lab receives funding from the Waterloo Foundation and the
   ESRC. I would like to thank Uta Frith for helpful comments on the
   manuscript. The author has no conflicts of interest.
CR Aldridge MA, 2000, DEVELOPMENTAL SCI, V3, P294, DOI 10.1111/1467-7687.00123
   Ambrosini E, 2012, J EXP PSYCHOL HUMAN, V38, P263, DOI 10.1037/a0026570
   Arnstein D, 2011, J NEUROSCI, V31, P14243, DOI 10.1523/JNEUROSCI.0963-11.2011
   Avikainen S, 1999, NEUROREPORT, V10, P3467, DOI 10.1097/00001756-199911260-00001
   Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Bastiaansen JA, 2011, BIOL PSYCHIAT, V69, P832, DOI 10.1016/j.biopsych.2010.11.007
   Bernier R, 2007, BRAIN COGNITION, V64, P228, DOI 10.1016/j.bandc.2007.03.004
   Bird G, 2007, P ROY SOC B-BIOL SCI, V274, P3027, DOI 10.1098/rspb.2007.1019
   Bird G, 2006, NEUROIMAGE, V31, P1614, DOI 10.1016/j.neuroimage.2006.02.037
   Boria S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005596
   Brambilla P, 2003, BRAIN RES BULL, V61, P557, DOI 10.1016/j.brainresbull.2003.06.001
   Buccino G, 2004, NEURON, V42, P323, DOI 10.1016/S0896-6273(04)00181-3
   Carpenter M, 2001, J AUTISM DEV DISORD, V31, P589, DOI 10.1023/A:1013251112392
   Caspers S, 2010, NEUROIMAGE, V50, P1148, DOI 10.1016/j.neuroimage.2009.12.112
   Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104
   Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781
   Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007
   Cisek P, 2010, ANNU REV NEUROSCI, V33, P269, DOI 10.1146/annurev.neuro.051508.135409
   Cook J, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00175
   Cook JL, 2012, J AUTISM DEV DISORD, V42, P1045, DOI 10.1007/s10803-011-1341-7
   Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611
   Dijksterhuis A, 2001, ADV EXP SOC PSYCHOL, V33, P1, DOI 10.1016/S0065-2601(01)80003-4
   Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
   Dinstein I, 2010, NEURON, V66, P461, DOI 10.1016/j.neuron.2010.03.034
   Dinstein I., 2008, CURR BIOL, P3
   Duerden EG, 2012, AUTISM RES, V5, P49, DOI 10.1002/aur.235
   Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010
   Enticott PG, 2012, BIOL PSYCHIAT, V71, P427, DOI 10.1016/j.biopsych.2011.09.001
   FADIGA L, 1995, J NEUROPHYSIOL, V73, P2608
   Falck-Ytter T., 2009, BIOL LETT, V6, P375
   Falck-Ytter T, 2012, J AUTISM DEV DISORD, V42, P2236, DOI 10.1007/s10803-012-1471-6
   Fan YT, 2010, J CHILD PSYCHOL PSYC, V51, P981, DOI 10.1111/j.1469-7610.2010.02269.x
   Fitzgerald PB, 2006, CLIN NEUROPHYSIOL, V117, P2584, DOI 10.1016/j.clinph.2006.06.712
   Flanagan JR, 2003, NATURE, V424, P769, DOI 10.1038/nature01861
   Fogassi L, 2005, SCIENCE, V308, P662, DOI 10.1126/science.1106138
   Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3
   Frith C, 2003, NOVART FDN SYMP, V251, P149
   Frith U., 2012, Q J EXPT PSYCHOL SEP, P37
   Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9
   Gallese V, 2007, PHILOS T R SOC B, V362, P659, DOI 10.1098/rstb.2006.2002
   Gallese V, 2008, SOC NEUROSCI, V3, P317, DOI 10.1080/17470910701563608
   Gallese V, 2009, DEV PSYCHOL, V45, P103, DOI 10.1037/a0014436
   Gallese V, 1996, BRAIN, V119, P593, DOI 10.1093/brain/119.2.593
   Gowen E., 2012, J AUTISM DEV DISORDE
   Grecucci A., 2012, J AUTISM DEV DISORDE
   Grezes J, 2009, NEUROPSYCHOLOGIA, V47, P1816, DOI 10.1016/j.neuropsychologia.2009.02.021
   Grill-Spector K, 2006, TRENDS COGN SCI, V10, P14, DOI 10.1016/j.tics.2005.11.006
   Grossi D., 2012, J INTELL DISABIL RES, P1
   Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069
   Hamilton A. F., 2007, ATTENTION PERFORMANC, V22
   Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022
   Hamilton AFDC, 2008, Q J EXP PSYCHOL, V61, P101, DOI 10.1080/17470210701508798
   Heyes C, 2010, NEUROSCI BIOBEHAV R, V34, P575, DOI 10.1016/j.neubiorev.2009.11.007
   Hickok G, 2009, J COGNITIVE NEUROSCI, V21, P1229, DOI 10.1162/jocn.2009.21189
   Hogeveen J, 2012, J NEUROSCI, V32, P5984, DOI 10.1523/JNEUROSCI.5938-11.2012
   Honaga E, 2010, NEUROSCI LETT, V478, P141, DOI 10.1016/j.neulet.2010.05.004
   Iacoboni M, 1999, SCIENCE, V286, P2526, DOI 10.1126/science.286.5449.2526
   Ingersoll B, 2003, J AUTISM DEV DISORD, V33, P673, DOI 10.1023/B:JADD.0000006003.26667.f8
   Ingersoll B., 2007, RES AUTISM SPECT DIS, V2, P332
   Kana R.K., 2010, NEUROSCI BIOBEHAV R, V35, P1
   Keysers C, 2010, NAT REV NEUROSCI, V11, P417, DOI 10.1038/nrn2833
   Kilner JM, 2009, J NEUROSCI, V29, P10153, DOI 10.1523/JNEUROSCI.2668-09.2009
   Kilner JM, 2006, SOC COGN AFFECT NEUR, V1, P143, DOI 10.1093/scan/nsl017
   Kriegeskorte N, 2009, NAT NEUROSCI, V12, P535, DOI 10.1038/nn.2303
   lacoboni M., 2006, NATURE REV NEUROSCIE, V7, P942
   Lakin JL, 2003, PSYCHOL SCI, V14, P334, DOI 10.1111/1467-9280.14481
   Marsh LE, 2011, NEUROIMAGE, V56, P1511, DOI 10.1016/j.neuroimage.2011.02.003
   Martineau J, 2008, INT J PSYCHOPHYSIOL, V68, P35, DOI 10.1016/j.ijpsycho.2008.01.002
   Martineau J, 2010, BRAIN RES, V1320, P168, DOI 10.1016/j.brainres.2010.01.035
   McCabe DP, 2008, COGNITION, V107, P343, DOI 10.1016/j.cognition.2007.07.017
   Michael J, 2011, PHILOS EXPLOR, V14, P185, DOI 10.1080/13869795.2011.569747
   Muthukumaraswamy SD, 2004, COGNITIVE BRAIN RES, V19, P195, DOI 10.1016/j.cogbrainres.2003.12.001
   Nieuwenhuis S, 2011, NAT NEUROSCI, V14, P1105, DOI 10.1038/nn.2886
   Nishitani N, 2004, ANN NEUROL, V55, P558, DOI 10.1002/ana.20031
   Norman D., 1986, CONSCIOUSNESS SELF R, V4, P1
   Oberman LM, 2008, NEUROPSYCHOLOGIA, V46, P1558, DOI 10.1016/j.neuropsychologia.2008.01.010
   Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310
   Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
   Oosterhof NN, 2010, J NEUROPHYSIOL, V104, P1077, DOI 10.1152/jn.00326.2010
   Pascolo PB, 2012, J ELECTROMYOGR KINES, V22, P98, DOI 10.1016/j.jelekin.2011.07.009
   Pellicano E, 2012, TRENDS COGN SCI, V16, P504, DOI 10.1016/j.tics.2012.08.009
   Perkins T, 2010, J CLIN NEUROSCI, V17, P1239, DOI 10.1016/j.jocn.2010.01.026
   Philip RCM, 2012, NEUROSCI BIOBEHAV R, V36, P901, DOI 10.1016/j.neubiorev.2011.10.008
   Raymaekers R, 2009, BRAIN RES, V1304, P113, DOI 10.1016/j.brainres.2009.09.068
   Rizzolatti G, 2009, NAT CLIN PRACT NEURO, V5, P24, DOI 10.1038/ncpneuro0990
   Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230
   Rizzolatti G, 2010, EXP BRAIN RES, V200, P223, DOI 10.1007/s00221-009-2002-3
   Rizzolatti G, 2010, NAT REV NEUROSCI, V11, P264, DOI 10.1038/nrn2805
   Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043
   Rogers SJ, 1996, CHILD DEV, V67, P2060, DOI 10.2307/1131609
   Rosander K, 2011, NEUROPSYCHOLOGIA, V49, P2911, DOI 10.1016/j.neuropsychologia.2011.06.018
   ROTHWELL JC, 1991, EXP PHYSIOL, V76, P159
   SALMELIN R, 1994, NEUROSCIENCE, V60, P537, DOI 10.1016/0306-4522(94)90263-1
   Schulte-Ruther M, 2011, SOC NEUROSCI-UK, V6, P1, DOI 10.1080/17470911003708032
   Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170
   Southgate V, 2008, TRENDS COGN SCI, V12, P225, DOI 10.1016/j.tics.2008.03.005
   Sparaci L, 2012, NEUROPSYCHOLOGIA, V50, P1639, DOI 10.1016/j.neuropsychologia.2012.03.019
   Spengler S, 2010, BIOL PSYCHIAT, V68, P1148, DOI 10.1016/j.biopsych.2010.09.017
   Spunt RP, 2010, PSYCHOL SCI, V21, P1593, DOI 10.1177/0956797610386618
   Spunt RP, 2011, J COGNITIVE NEUROSCI, V23, P63, DOI 10.1162/jocn.2010.21446
   Strafella AP, 2001, J NEUROPHYSIOL, V85, P2624
   Theoret H, 2005, CURR BIOL, V15, pR84, DOI 10.1016/j.cub.2005.01.022
   Toal F, 2010, PSYCHOL MED, V40, P1171, DOI 10.1017/S0033291709991541
   Vivanti G, 2008, J EXP CHILD PSYCHOL, V101, P186, DOI 10.1016/j.jecp.2008.04.008
   Vivanti G, 2011, DEV PSYCHOL, V47, P841, DOI 10.1037/a0023105
   Wan CY, 2010, BRAIN RES BULL, V82, P161, DOI 10.1016/j.brainresbull.2010.04.010
   Wang Y., 2010, BIOL LETT, V7, P7, DOI DOI 10.1098/RSB1.2010.0279
   Wang Y, 2011, J NEUROSCI, V31, P12001, DOI 10.1523/JNEUROSCI.0845-11.2011
   Wang Y, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00153
   Weisberg DS, 2008, J COGNITIVE NEUROSCI, V20, P470, DOI 10.1162/jocn.2008.20.3.470
   Wicker B, 2003, NEURON, V40, P655, DOI 10.1016/S0896-6273(03)00679-2
   Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a
   Williams JHG, 2006, NEUROPSYCHOLOGIA, V44, P610, DOI 10.1016/j.neuropsychologia.2005.06.010
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
   Yamasaki S, 2010, BIOL PSYCHIAT, V68, P1141, DOI 10.1016/j.biopsych.2010.07.012
   Ziemann U, 2004, CLIN NEUROPHYSIOL, V115, P1717, DOI 10.1016/j.clinph.2004.03.006
NR 117
TC 27
Z9 28
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1878-9293
J9 DEV COGN NEUROS-NETH
JI Dev. Cogn. Neurosci.
PY 2013
VL 3
BP 91
EP 105
DI 10.1016/j.dcn.2012.09.008
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA 095EU
UT WOS:000315318300011
PM 23245224
ER

PT J
AU Mathersul, D
   McDonald, S
   Rushby, JA
AF Mathersul, Danielle
   McDonald, Skye
   Rushby, Jacqueline A.
TI Psychophysiological correlates of social judgement in high-functioning
   adults with autism spectrum disorder
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Article
DE Autism; Asperger's; Trust; Approachability; Skin conductance; Arousal
ID CEREBRAL-BLOOD-FLOW; ASPERGER-SYNDROME; FACIAL EXPRESSIONS; ORIENTING
   RESPONSE; SKIN-CONDUCTANCE; PREFRONTAL CORTEX; HEART-RATE; CHILDREN;
   EMOTION; FACE
AB Neural structures involved in social cognition (e.g., amygdala, orbitofrontal cortex) have been implicated in judgements of trustworthiness. These regions are also functionally atypical in individuals with autism spectrum disorders (ASDs). Studies investigating judgements of trustworthiness in ASDs have suggested possible disruptions in the allocation of significance to social stimuli. Concurrent measures of autonomic responses provide further insight into these deficits, given their role in the direction of attention and allocation of significance. Thirty high-functioning adults with ASDs and 31 non-clinical controls viewed neutral images piloted as most "positive" and "negative." Skin conductance (SCR, SCL) and evoked cardiac deceleration (ECD) were recorded. Adults with ASDs did not differ from controls in ratings of trustworthiness. However, they displayed atypical SCRs, providing further support for a disruption in the allocation of emotional significance. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Mathersul, Danielle; McDonald, Skye; Rushby, Jacqueline A.] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
RP Mathersul, D (reprint author), Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
EM dmathersul@psy.unsw.edu.au
RI McDonald, Skye/G-4118-2014
OI McDonald, Skye/0000-0003-0723-6094
FU Australian Postgraduate Award (APA); Australian National Health and
   Medical Research Council (NHMRC) [APP1013796]; Australian NHMRC
FX DM is supported by an Australian Postgraduate Award (APA). JAR is
   supported by an Australian National Health and Medical Research Council
   (NHMRC) Postdoctoral Fellowship (Clinical Training; APP1013796). This
   research was funded by the Australian NHMRC. We would like to thank the
   individuals who gave their time to participate in this study and the
   clinicians who assisted with participant recruitment.
CR Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6
   Adolphs R, 2002, CURR OPIN NEUROBIOL, V12, P169, DOI 10.1016/S0959-4388(02)00301-X
   Adolphs R, 1998, NATURE, V393, P470, DOI 10.1038/30982
   Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019
   American Psychiatric Association (APA), 2011, DSM 5 DEV
   (APA) APA, 2000, DIAGN STAT MAN MENT
   Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014
   BARONCOHEN S, 1988, J AUTISM DEV DISORD, V18, P379, DOI 10.1007/BF02212194
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   BARONCOHEN S, 1989, J CHILD PSYCHOL PSYC, V30, P285, DOI 10.1111/j.1469-7610.1989.tb00241.x
   Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x
   Barry RJ, 2004, INTEGR PHYS BEH SCI, V39, P166, DOI 10.1007/BF02734437
   Barry R.J., 1990, J BIOL SCI, V25, P99
   Barry RJ, 2008, BIOL PSYCHOL, V77, P304, DOI 10.1016/j.biopsycho.2007.11.002
   BARRY RJ, 1990, PAVLOVIAN J BIOL SCI, V25, P93
   Baxter MG, 2000, J NEUROSCI, V20, P4311
   Ben Shalom D, 2006, J AUTISM DEV DISORD, V36, P395, DOI 10.1007/s10803-006-0077-2
   Boucsein W., 1992, ELECTRODERMAL ACTIVI
   Bradley MM, 2001, EMOTION, V1, P276, DOI 10.1037//1528-3542.1.3.276
   Couture SM, 2010, PSYCHOL MED, V40, P569, DOI 10.1017/S003329170999078X
   Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203
   Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421
   Davis M, 1997, NEUROPSYCHIATRY LIMB, P71
   Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6
   De Martino B, 2008, J NEUROSCI, V28, P10746, DOI 10.1523/JNEUROSCI.2895-08.2008
   Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022
   Frith U., 1989, AUTISM EXPLAINING EN
   FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8
   GRAHAM FK, 1966, PSYCHOL BULL, V65, P305, DOI 10.1037/h0023258
   Happe F, 1996, BRAIN, V119, P1377, DOI 10.1093/brain/119.4.1377
   Haxby JV, 2000, TRENDS COGN SCI, V4, P223, DOI 10.1016/S1364-6613(00)01482-0
   Hermans EJ, 2009, BIOL PSYCHOL, V80, P348, DOI 10.1016/j.biopsycho.2008.12.002
   HODES RL, 1985, PSYCHOPHYSIOLOGY, V22, P545, DOI 10.1111/j.1469-8986.1985.tb01649.x
   Hubert BE, 2009, AUTISM, V13, P9, DOI 10.1177/1362361308091649
   IACONO WG, 1983, PSYCHOPHYSIOLOGY, V20, P71, DOI 10.1111/j.1469-8986.1983.tb00905.x
   Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809
   Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
   LANE RD, 1987, AM J PSYCHIAT, V144, P133
   LANG PJ, 1990, PSYCHOL REV, V97, P377, DOI 10.1037//0033-295X.97.3.377
   LANG PJ, 1995, AM PSYCHOL, V50, P372, DOI 10.1037//0003-066X.50.5.372
   LeDoux J. E., 1993, HDB EMOTIONS, P109
   Lin HP, 2011, J CLIN PSYCHOL, V67, P1080, DOI 10.1002/jclp.20833
   Loveland KA, 2008, PERCEPT MOTOR SKILL, V107, P557, DOI 10.2466/PMS.107.2.557-575
   LYKKEN DT, 1971, PSYCHOPHYSIOLOGY, V8, P656, DOI 10.1111/j.1469-8986.1971.tb00501.x
   Magnuson KM, 2011, J DEV BEHAV PEDIATR, V32, P332, DOI 10.1097/DBP.0b013e318213f56c
   MALTZMAN I, 1977, J EXP PSYCHOL GEN, V106, P111, DOI 10.1037/0096-3445.106.2.111
   Mathersul D., PHYSL BEHAV
   McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x
   Oberman LM, 2009, DEVELOPMENTAL SCI, V12, P510, DOI 10.1111/j.1467-7687.2008.00796.x
   Ohnishi T, 2000, BRAIN, V123, P1838, DOI 10.1093/brain/123.9.1838
   Ongur D, 2000, CEREB CORTEX, V10, P206, DOI 10.1093/cercor/10.3.206
   OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   Phillips ML, 2003, BIOL PSYCHIAT, V54, P504, DOI 10.1016/S0006-3223(03)00168-9
   Pierce K, 2011, ARCH GEN PSYCHIAT, V68, P101, DOI 10.1001/archgenpsychiatry.2010.113
   Pinkham AE, 2008, SCHIZOPHR RES, V99, P164, DOI 10.1016/j.schres.2007.10.024
   Ritvo RA, 2011, J AUTISM DEV DISORD, V41, P1076, DOI 10.1007/s10803-010-1133-5
   Ritvo RA, 2008, J AUTISM DEV DISORD, V38, P213, DOI 10.1007/s10803-007-0380-6
   Rolls E. T., 1999, BRAIN EMOTION
   Rushby JA, 2007, BIOL PSYCHOL, V75, P248, DOI 10.1016/j.biopsycho.2007.03.003
   Rutherford MD, 2002, J AUTISM DEV DISORD, V32, P189, DOI 10.1023/A:1015497629971
   Sabatinelli D, 2011, NEUROIMAGE, V54, P2524, DOI 10.1016/j.neuroimage.2010.10.011
   Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331
   Skokauskas N, 2010, PSYCHOPATHOLOGY, V43, P8, DOI 10.1159/000255958
   SOKOLOV EN, 1990, PAVLOVIAN J BIOL SCI, V25, P142
   Tottenham N, 2009, PSYCHIAT RES, V168, P242, DOI 10.1016/j.psychres.2008.05.006
   Turpin G., 1983, ORIENTING RESPONSE, P1
   Wechsler D, 1999, WECHSLER ABBREVIATED
   White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003
   Winston JS, 2002, NAT NEUROSCI, V5, P277, DOI 10.1038/nn816
   Wise V, 2011, INT J PSYCHOPHYSIOL, V79, P155, DOI 10.1016/j.ijpsycho.2010.10.002
   Yassa MA, 2012, J PSYCHIATR RES, V46, P1045, DOI 10.1016/j.jpsychires.2012.04.013
NR 75
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
EI 1872-7697
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD JAN
PY 2013
VL 87
IS 1
BP 88
EP 94
DI 10.1016/j.ijpsycho.2012.11.005
PG 7
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 093GF
UT WOS:000315179000012
PM 23183316
ER

PT J
AU Cardoso, RRD
   Ponte, M
   Leite, V
AF De Almeida Cardoso, Roberto R.
   Ponte, Marina
   Leite, Vanuza
TI Protective Action of Camel Milk in Mice Inoculated with Salmonella
   enterica
SO ISRAEL MEDICAL ASSOCIATION JOURNAL
LA English
DT Article
DE camel milk; cow's milk; immunoglobulins; salmonellosis; infection
ID LACTOFERRIN; ANTIBODIES; PROTEINS; CHILDREN; DOMAIN
AB Background: In some countries people believe that camel milk can protect against various aggressors, whether due to infections, diabetes, or even autism. Little has been scientifically demonstrated regarding the veracity of these beliefs.
   Objectives: To study the anti-infectious action of camel milk.
   Methods: Fifty mice were divided into 5 groups of 10 animals each: 3 control groups and 2 test groups. Except for one of the control groups, all groups were intraperitoneally inoculated with a strain of Salmonella enterica. The rations in the test groups were supplemented with camel milk or cow milk.
   Results: A statistically significant survival was observed in the mice supplemented with camel milk. The death rate after Salmonella inoculation was only 40% in the study group, as compared to 100% in the control groups where the mice were not protected, and 80% in the group supplemented with cow milk and injected with Salmonella.
   Conclusions: Camel milk is an excellent nutrient and because of its specific properties, particularly its anti-infectious action, should be used to replace other milks. IMAJ 2013; 15:5-8
C1 [De Almeida Cardoso, Roberto R.] Fac Integradas Planalto Cent, FACIPLAC, Dept Allergy & Immunopathol, Brasilia, DF, Brazil.
   [Ponte, Marina; Leite, Vanuza] Santa Paula Lab, Brasilia, DF, Brazil.
RP Cardoso, RRD (reprint author), Clin Alergia Sao Joaquim, Quadra 1 Bloco E,Salas 301-313-314, BR-70303900 Brasilia, DF, Brazil.
EM rronaldac@gmail.com
CR Agrawal RP, 1984, DIABETES RES CLIN PR, V2, P290
   Al-Awadi FM, 2001, J DAIRY RES, V68, P463, DOI 10.1017/S0022029901005003
   Al-Hammadi S., 2010, ALLERGY, V65, P1622
   Baker EN, 2005, CELL MOL LIFE SCI, V62, P2531, DOI 10.1007/s00018-005-5368-9
   Cardoso Ronald R A, 2010, Rev Alerg Mex, V57, P26
   Conesa C, 2008, COMP BIOCHEM PHYS B, V150, P131, DOI 10.1016/j.cbpb.2008.02.005
   DUHAIMAN AS, 1988, COMP BIOCHEM PHYS B, V91, P793, DOI 10.1016/0305-0491(88)90210-6
   Ehlayel MS, 2011, ALLERGY ASTHMA PROC, V32, P255, DOI 10.2500/aap.2011.32.3429
   FARAH Z, 1992, INT J VITAM NUTR RES, V62, P30
   HAMERSCASTERMAN C, 1993, NATURE, V363, P446, DOI 10.1038/363446a0
   Hultberg A, 2007, BMC BIOTECHNOL, V7, P1
   Lauwereys M, 1998, EMBO J, V17, P3512, DOI 10.1093/emboj/17.13.3512
   Maghraby AS, 2005, ASIA PAC J CLIN NUTR, V14, P432
   Martin F, 1997, PROTEIN ENG, V10, P607, DOI 10.1093/protein/10.5.607
   Merin U, 2001, LIVEST PROD SCI, V67, P297, DOI 10.1016/S0301-6226(00)00198-6
   Musinga M, 2008, CAMEL MILK IND KENYA
   Pant N, 2006, J INFECT DIS, V194, P1580, DOI 10.1086/508747
   Redwan EM, 2007, J IMMUNOASS IMMUNOCH, V28, P267, DOI 10.1080/15321810701454839
   Salami M, 2010, J AGR FOOD CHEM, V58, P3297, DOI 10.1021/jf9033283
   Saltanat Heinayat, 2009, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, V25, P431
   Shabo Y, 2005, ISRAEL MED ASSOC J, V7, P796
   UNGAR-WARON H, 1987, Israel Journal of Veterinary Medicine, V43, P198
   Vos AP, 2007, CRIT REV IMMUNOL, V27, P97
   YOKOTA T, 1992, CANCER RES, V52, P3402
   Zinger-Yosovich KD, 2010, J DAIRY SCI, V93, P473, DOI 10.3168/jds.2009-2381
NR 25
TC 1
Z9 1
PU ISRAEL MEDICAL ASSOC JOURNAL
PI RAMAT GAN
PA 2 TWIN TOWERS, 11TH FL, 35 JABOTINSKY ST, PO BOX 3604, RAMAT GAN 52136,
   ISRAEL
SN 1565-1088
J9 ISR MED ASSOC J
JI Isr. Med. Assoc. J.
PD JAN
PY 2013
VL 15
IS 1
BP 5
EP 8
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 095AV
UT WOS:000315307800001
PM 23484230
ER

PT J
AU Yagil, R
AF Yagil, Reuven
TI Camel Milk and its Unique Anti-Diarrheal Properties
SO ISRAEL MEDICAL ASSOCIATION JOURNAL
LA English
DT Editorial Material
DE immunoglobulins; protective proteins; Johne's disease; casomorphine;
   autism syndrome; Crohn's disease; retrovirus
ID VACCINATION
C1 [Yagil, Reuven] Ben Gurion Univ Negev, Fac Hlth Sci, IL-84105 Beer Sheva, Israel.
RP Yagil, R (reprint author), 14 Bar Kochba St, IL-84231 Beer Sheva, Israel.
EM reuven.yagil@gmail.com
CR [Anonymous], 2006, BBC NEWS
   Cardoso R, 2012, IMAJ ISR MED ASS J, V14, P5
   Choi CQ, 2006, LLAMAS ENLISTED THWA
   Corti S, 2002, MICROBIOLOGY, V2, P2
   ELAGAMY ESI, 1992, J DAIRY RES, V59, P169
   Fagan D, 2001, CROHNSCANADA PARATUB
   Greenberg HB, 2009, GASTROENTEROLOGY, V136, P1939, DOI 10.1053/j.gastro.2009.02.076
   HAMERSCASTERMAN C, 1993, NATURE, V363, P446, DOI 10.1038/363446a0
   Kappeler S, 1998, THESIS ETH ZURICH
   Khan MM, 1974, SAHIH BUKHARI BOOK, V71, P582
   Levi A, 2011, BRIDGING KNOWLEDGE T
   Murch S, 2005, J PEDIATR-US, V146, P582, DOI 10.1016/j.jpeds.2005.02.026
   Reichelt KL, 2003, NUTR NEUROSCI, V6, P19, DOI 10.1080/1028415021000042839
   Santema W, 2011, TIJDSHCRIFT DIERGENE, V136, P580
   Shabo Y, 2008, J CAMEL PRACT RES, V15, P55
   Shabo Y, 2005, INT J DISABIL HUM DE, V4, P67
   Shoenfeld Y, 2000, CLIN EXP RHEUMATOL, V18, P181
   Smit C, 2010, BENEFITS CAMELS MILK
   Sun Z., 1999, AUTISM, V3, P85, DOI 10.1177/1362361399003001007
   WYATT R G, 1969, Journal of Tropical Pediatrics, V15, P159
NR 20
TC 3
Z9 3
PU ISRAEL MEDICAL ASSOC JOURNAL
PI RAMAT GAN
PA 2 TWIN TOWERS, 11TH FL, 35 JABOTINSKY ST, PO BOX 3604, RAMAT GAN 52136,
   ISRAEL
SN 1565-1088
J9 ISR MED ASSOC J
JI Isr. Med. Assoc. J.
PD JAN
PY 2013
VL 15
IS 1
BP 35
EP 36
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 095AV
UT WOS:000315307800008
PM 23484237
ER

PT J
AU Csaba, G
AF Csaba, Gyoergy
TI Hormonal imprinting in the central nervous system: causes and
   consequences
SO ORVOSI HETILAP
LA Hungarian
DT Article
DE hormonal imprinting; faulty imprinting; brain; autism; schizophrenia
ID NEONATAL BENZPYRENE TREATMENT; BRAIN-SEROTONIN CONTENT; VITAMIN-D
   TREATMENT; RAT IMMUNE CELLS; ADULT MALE RATS; SEXUAL-BEHAVIOR;
   SOCIAL-BEHAVIOR; FEMALE RATS; PERINATAL EXPOSURE; LATE PREGNANCY
AB Hormonal imprinting in the central nervous system: causes and consequences The notion of the perinatal "hormonal imprinting" has been published at first in 1980 and since that time it spred expansively. The imprintig develops at the first encounter between the developing receptor and the target hormone - possibly by the alteration of the methylation pattern of DNA - and it is transmitted to the progeny generations of the cell. This is needed for the complete development of the receptor's binding capacity. However, molecules similar to the target hormone (hormone-analogues, drugs, chemicals, environmental pollutants) can also bind to the developing receptor, causing faulty imprinting with life-long consequences. This can promote pathological conditions. Later it was cleared that in other critical periods such as puberty, imprinting also can be provoked, even in any age in differentiating cells. The central nervous system (brain) also can be mistakenly imprinted, which durably influences the dopaminergic, serotonergic and noradrenergic system and this can be manifested - in animal experiments - in alterations of the sexual and social behavior. In our modern age the faulty hormonal imprintig is inavoidable because of the mass of medicaments, chemicals, the presence of hormone-like materials (e. g. soya phytosteroids) in the food, and environmental pollutants. The author especially emphasizes the danger of oxytocin, as a perinatal imprinter, as it is used very broadly and can basically influence the emotional and social spheres and the appearance of certain diseases such as auitism, schizophrenia and parkinsonism. The danger of perinatal imprinters is growing, considering their effects on the human evolution. Orv. Hetil., 2013, 154, 128-135.
C1 [Csaba, Gyoergy] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Sejt & Immunbiol Int, Budapest, Hungary.
RP Csaba, G (reprint author), Pf 370, H-1445 Budapest, Hungary.
EM csagyor@dgci.sote.hu
CR Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107
   Bales Karen L, 2011, Front Psychiatry, V2, P24, DOI 10.3389/fpsyt.2011.00024
   Bales KL, 2004, PHYSIOL BEHAV, V81, P519, DOI 10.1016/j.physbeh.2004.02.016
   Bales KL, 2007, HORM BEHAV, V52, P274, DOI 10.1016/j.yhbeh.2007.05.004
   Barch DM, 2012, TRENDS COGN SCI, V16, P27, DOI 10.1016/j.tics.2011.11.015
   Baskerville TA, 2010, CNS NEUROSCI THER, V16, pe92, DOI 10.1111/j.1755-5949.2010.00154.x
   Baskerville TA, 2008, PROG BRAIN RES, V170, P277, DOI 10.1016/S0079-6123(08)00423-8
   Bateman HL, 2008, NEUROTOXICOLOGY, V29, P988, DOI 10.1016/j.neuro.2008.06.008
   BENESOVA O, 1989, NEUROPHARMACOLOGY, V28, P89, DOI 10.1016/0028-3908(89)90073-7
   Bigsby R, 1999, ENVIRON HEALTH PERSP, V107, P613, DOI 10.2307/3434553
   Carter CS, 2003, PHYSIOL BEHAV, V79, P383, DOI 10.1016/S0031-9384(03)00151-3
   Crinella FM, 2012, EXPERT REV NEUROTHER, V12, P395, DOI [10.1586/ern.12.2, 10.1586/ERN.12.2]
   Csaba G, 1997, HUM EXP TOXICOL, V16, P193
   Csaba G, 2002, Acta Physiol Hung, V89, P463, DOI 10.1556/APhysiol.89.2002.4.6
   Csaba G, 1998, HUM EXP TOXICOL, V17, P88, DOI 10.1191/096032798678908332
   Csaba György, 2011, Clin Epigenetics, V2, P187, DOI 10.1007/s13148-011-0024-8
   CSABA G, 1995, HORM METAB RES, V27, P279, DOI 10.1055/s-2007-979959
   Csaba G., 2001, Acta Physiologica Hungarica, V88, P131, DOI 10.1556/APhysiol.88.2001.2.4
   Csaba G, 2003, LIFE SCI, V73, P2703, DOI 10.1016/S0024-3205(03)00666-0
   Csaba G, 2007, HORM METAB RES, V39, P197, DOI 10.1055/s-2007-970418
   CSABA G, 1980, BIOL REV, V55, P47, DOI 10.1111/j.1469-185X.1980.tb00687.x
   CSABA G, 1984, ACTA PHYSIOL HUNG, V63, P93
   Csaba G, 1997, HUM EXP TOXICOL, V16, P553
   CSABA G, 1975, EXPERIENTIA, V31, P1097, DOI 10.1007/BF02326980
   CSABA G, 1986, MED BIOL, V64, P193
   CSABA G, 1993, J DEV PHYSIOL, V19, P67
   Csaba G, 2001, PHARMACOL RES, V43, P531, DOI 10.1006/phrs.2001.0818
   Csaba G, 2004, HORM METAB RES, V36, P39, DOI 10.1055/s-2004-814101
   Csaba G, 2005, BRAIN DEV-JPN, V27, P465, DOI 10.1016/j.braindev.2004.12.008
   Csaba Gyoergy, 2010, Orvosi Hetilap, V151, P1323, DOI 10.1556/OH.2010.28936
   Csaba G, 2003, LIFE SCI, V73, P103, DOI 10.1016/S0024-3205(03)00254-6
   CSABA G, 1976, EXPERIENTIA, V32, P651, DOI 10.1007/BF01990215
   Csaba G, 2005, HORM METAB RES, V37, P172, DOI 10.1055/s-2005-861303
   Csaba Gyoergy, 2011, Orvosi Hetilap, V152, P777, DOI 10.1556/OH.2011.29122
   CSABA G, 1985, J ENDOCRINOL INVEST, V8, P557
   de Castro RM, 2001, BRAZ J MED BIOL RES, V34, P121
   Eaton JL, 2012, DEV PSYCHOBIOL, V54, P92, DOI 10.1002/dev.20566
   Engell MD, 2006, NEUROTOXICOL TERATOL, V28, P103, DOI 10.1016/j.ntt.2005.10.002
   Feng PF, 2001, DEV BRAIN RES, V129, P107, DOI 10.1016/S0165-3806(01)00158-4
   Gorski RA, 2002, ADV EXP MED BIOL, V511, P57
   Green JJ, 2010, NEUROTHERAPEUTICS, V7, P250, DOI 10.1016/j.nurt.2010.05.006
   Guilloteau P, 2009, J PHYSIOL PHARMACOL, V60, P17
   Harony H, 2010, NEUROSIGNALS, V18, P82, DOI 10.1159/000321035
   Hashemi F., 2013, REPROD SCI
   Ichinohashi Y, 2012, EARLY HUM DEV, DOI [10.1016/j.earlhum-dev.2012.10.007, DOI 10.1016/J.EARLHUM-DEV.2012.10.007]
   Ishizuka M, 2003, J BIOCHEM MOL TOXIC, V17, P278, DOI 10.1002/jbt.10090
   Jefferson WN, 2007, REPROD TOXICOL, V23, P308, DOI 10.1016/j.reprotox.2006.11.012
   Kamphuis PJGH, 2004, NEUROPHARMACOLOGY, V47, P461, DOI 10.1016/j.neuropharm.2004.04.008
   KARABELYOS C, 1994, HORM METAB RES, V26, P371, DOI 10.1055/s-2007-1001709
   Karabelyos C, 1998, GEN PHARMACOL, V31, P367, DOI 10.1016/S0306-3623(98)00037-8
   Keyes KM, 2012, INT J EPIDEMIOL, V41, P495, DOI 10.1093/ije/dyr193
   Kim H. J., 2012, INT NEUROUROL J, V16, P57
   Kohidai L, 2012, CELL BIOL INT, V36, P951, DOI 10.1042/CBI20110677
   KORENBROT CC, 1975, ENDOCRINOLOGY, V97, P709
   Kouki T, 2003, HORM BEHAV, V44, P140, DOI 10.1016/S0018-506X(03)00122-3
   Lee D. A, 2012, INT J DEV NEUROSCI, DOI [10.1016/j.ijdevneu.2012.03.300, DOI 10.1016/J.IJDEVNEU.2012.03.300]
   Lee HJ, 2009, PROG NEUROBIOL, V88, P127, DOI 10.1016/j.pneurobio.2009.04.001
   Leonelli C, 2011, REPROD TOXICOL, V31, P10, DOI 10.1016/j.reprotox.2010.08.003
   Lukas M, 2012, BEHAV BRAIN RES, DOI [10.1016/j.bbr.2012.08.011, DOI 10.1016/J.BBR.2012.08.011.]
   Luzzati F, 2007, NEURODEGENER DIS, V4, P322, DOI 10.1159/000101889
   Maciag D, 2006, BRAIN RES, V1125, P171, DOI 10.1016/j.brainres.2006.10.009
   MacKenzie IZ, 2006, REPRODUCTION, V131, P989, DOI 10.1530/rep.1.00709
   Malek A, 1996, J Matern Fetal Med, V5, P245, DOI 10.3109/14767059609025430
   Markina NV, 2006, ZH VYSSH NERV DEYAT+, V56, P491
   Martin-Du Pan RC, 2012, REV MED SUISSE, V21, P627
   Mehler MF, 2008, PROG NEUROBIOL, V86, P305, DOI 10.1016/j.pneurobio.2008.10.001
   Mendes da Silva C., 2002, ARQ NEURO-PSIQUIAT, V60, P928
   Mirzahosseini S, 1996, HUM EXP TOXICOL, V15, P573
   Moleti CA, 2009, MCN-AM J MATERN-CHIL, V34, P40, DOI 10.1097/01.NMC.0000343864.49366.66
   Neumann ID, 2008, J NEUROENDOCRINOL, V20, P858, DOI 10.1111/j.1365-2826.2008.01726.x
   Page DT, 2011, ANAT REC, V294, P1671, DOI 10.1002/ar.21473
   Pinborough-Zimmerman J, 2010, MATERN CHILD HLTH J, V14, P392, DOI 10.1007/s10995-009-0472-3
   Plothe C., 2009, INT J PRENATAL PERIN, V21, P181
   Richter CA, 2007, REPROD TOXICOL, V24, P199, DOI 10.1016/j.reprotox.2007.06.004
   Rougier A, 2004, NEUROCHIRURGIE, V50, P33, DOI 10.1016/S0028-3770(04)98303-8
   Rubin Leah H, 2010, Schizophr Res, V124, P13, DOI 10.1016/j.schres.2010.09.014
   Scheele D, 2012, J NEUROSCI, V32, P16074, DOI 10.1523/JNEUROSCI.2755-12.2012
   Skinner MK, 2011, BIRTH DEFECTS RES C, V93, P51, DOI 10.1002/bdrc.20199
   Sönnichsen A C, 2005, MMW Fortschr Med, V147, P31
   Stanley B, 2000, AM J PSYCHIAT, V157, P609, DOI 10.1176/appi.ajp.157.4.609
   Tekes K, 2009, BRAIN DEV-JPN, V31, P666, DOI 10.1016/j.braindev.2008.10.007
   Tekes K, 2009, BRAIN DEV-JPN, V31, P282, DOI 10.1016/j.braindev.2008.05.007
   Tekes K, 2011, INT J DEV NEUROSCI, V29, P171, DOI 10.1016/j.ijdevneu.2010.11.004
   Tekes K, 2007, ACTA PHYSIOL HUNG, V94, P183, DOI 10.1556/APhysiol.94.2007.3.3
   Tekes K, 2007, HORM METAB RES, V39, P479, DOI 10.1055/s-2007-981682
   Tekes K, 2006, HORM METAB RES, V38, P799, DOI 10.1055/s-2006-956181
   Tena-Sempere M, 2001, NEUROENDOCRINOLOGY, V73, P12, DOI 10.1159/000054616
   Wahl RUR, 2004, MED HYPOTHESES, V63, P456, DOI 10.1016/j.mehy.2004.03.008
   Yamasue H, 2012, J NEUROSCI, V32, P14109, DOI 10.1523/JNEUROSCI.3327-12.2012
   Yuan TF, 2011, CNS NEUROL DISORD-DR, V10, P433
NR 90
TC 0
Z9 0
PU AKADEMIAI KIADO RT
PI BUDAPEST
PA PRIELLE K U 19, PO BOX 245,, H-1117 BUDAPEST, HUNGARY
SN 0030-6002
J9 ORVOSI HETILAP
JI Orvosi Hetilap
PD JAN
PY 2013
VL 154
IS 4
BP 128
EP 135
DI 10.1556/OH.2013.29533
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 088AD
UT WOS:000314805300002
PM 23335722
ER

PT J
AU Grzywacz, A
   Malecka, I
   Suchanecka, A
   Bienkowski, P
   Samochowiec, J
AF Grzywacz, A.
   Malecka, I.
   Suchanecka, A.
   Bienkowski, P.
   Samochowiec, J.
TI Family-Based and Case-Control Study of Glutamate Receptor GRIK3
   Ser310Ala Polymorphism in Alcohol Dependence
SO EUROPEAN ADDICTION RESEARCH
LA English
DT Article
DE Alcohol dependence; Transmission disequilibrium test; Case-control
   study; Kainate receptor; GRIK3 gene
ID DELIRIUM-TREMENS; GLUTAMATE-RECEPTOR-6 GENE; FUNCTIONAL POLYMORPHISM;
   ASSOCIATION; INDIVIDUALS; LINKAGE; AUTISM
AB Aim: The aim of this study was to evaluate the role of the glutamate receptor subunit-7 (GluR7, GRIK 3) rs6691840 (Ser310Ala, T928G) in the pathogenesis of alcohol dependence (AD). Methods: DNA was provided from AD patients (n = 209) and healthy control subjects (n = 308) all of Polish descent. The history of alcoholism was obtained using the Polish version of the SSAGA (Semi-Structured Assessment for the Genetics of Alcoholism). We conducted case-control association study and transmission disequilibrium test (TDT). GRIK3 functional polymorphism was genotyped by the PCR-RFLP method. Results: Analyses revealed that polymorphism Ser310Ala of GRIK3 gene is not associated with AD or any of its subgroups. TDT reveled an adequate transmission of both alleles in the group of alcohol families. Conclusions: These findings replicate and extend our previous research results that do not support the hypothesis of the role of rs6691840 in the pathogenesis of AD. Copyright (C) 2012 S. Karger AG, Basel
C1 [Grzywacz, A.; Malecka, I.; Suchanecka, A.; Samochowiec, J.] Pomeranian Med Univ, Dept Psychiat, PL-71460 Szczecin, Poland.
   [Bienkowski, P.] Inst Psychiat & Neurol, Dept Pharmacol, Warsaw, Poland.
RP Samochowiec, J (reprint author), Pomeranian Med Univ, Dept Psychiat, Ul Broniewskiego 26, PL-71460 Szczecin, Poland.
EM samoj@pum.edu.p
RI Samochowiec, Jerzy/G-8175-2014; Malecka, Iwona/O-3247-2014; Grzywacz,
   Anna/O-3234-2014
OI Samochowiec, Jerzy/0000-0003-1438-583X; 
FU MNiSW [NN 402 466540]
FX This work was supported by MNiSW Grant NN 402 466540.
CR Begni S, 2002, MOL PSYCHIATR, V7, P416, DOI 10.1038/sj/mp/4000987
   BLUM K, 1991, ALCOHOL, V8, P409, DOI 10.1016/0741-8329(91)90693-Q
   BOHMAN M, 1984, ARCH GEN PSYCHIAT, V41, P872
   Bushell T. J., 1996, Neuropharmacology, V35, pA6, DOI 10.1016/0028-3908(96)84669-7
   CHARNESS ME, 1993, ALCOHOL CLIN EXP RES, V17, P2, DOI 10.1111/j.1530-0277.1993.tb00718.x
   Dick DM, 2002, ALCOHOL CLIN EXP RES, V26, P1453, DOI 10.1097/01.ALC.0000034037.10333.FD
   Dingledine R, 1999, PHARMACOL REV, V51, P7
   Fitzgerald LW, 1996, J NEUROSCI, V16, P274
   Foroud T, 2000, ALCOHOL CLIN EXP RES, V24, P933, DOI 10.1097/00000374-200007000-00001
   Freeman K, 2012, ALCOHOL CLIN EXP RES
   Gyetvai B, 2011, NEUROCHEM RES, V36, P1087, DOI 10.1007/s11064-011-0452-z
   Jamain S, 2002, MOL PSYCHIATR, V7, P302, DOI 10.1038/sj/mp/4000979
   Jaskolski F, 2005, J BIOL CHEM, V280, P22968, DOI 10.1074/jbc.M413166200
   Kebir O, 2011, EUR ADDICT RES, V17, P146, DOI 10.1159/000324849
   KENDLER KS, 1994, AM J PSYCHIAT, V151, P707
   Kortunay S, 2012, EUR ADDICT RES, V18, P161, DOI 10.1159/000336314
   Preuss UW, 2004, AM J MED GENET B, V130B, P109
   Preuss UW, 2006, PHARMACOGENOMICS J, V6, P34, DOI 10.1038/sj.tpj.6500343
   Preuss UW, 2002, ALCOHOL ALCOHOLISM, V37, P174, DOI 10.1093/alcalc/37.2.174
   PURANAM RS, 1993, SOMAT CELL MOLEC GEN, V19, P581, DOI 10.1007/BF01233385
   Samochowiec J, 2006, NEUROSCI LETT, V396, P159, DOI 10.1016/j.neulet.2005.11.030
   Schuckit MA, 2009, J SUBST ABUSE TREAT, V36, pS5, DOI 10.1016/j.jsat.2008.05.012
   Schuckit MA, 2008, J STUD ALCOHOL DRUGS, V69, P571
   Schuckit MA, 2000, AM J ADDICTION, V9, P103, DOI 10.1080/10550490050173172
   Shiffer HH, 2000, J NEUROSCI, V20, P9025
   Shiffer HH, 2007, AM J MED GENET B, V144B, P20
   Shuang M, 2004, AM J MED GENET B, V131B, P48, DOI 10.1002/ajmg.b.30025
   Strutz N, 2001, J NEUROSCI, V21, P401
   Tsai GC, 1998, ANNU REV MED, V49, P173
NR 29
TC 3
Z9 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1022-6877
J9 EUR ADDICT RES
JI Eur. Addict. Res.
PY 2013
VL 19
IS 1
BP 55
EP 59
DI 10.1159/000341714
PG 5
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA 087KA
UT WOS:000314759000008
PM 23006490
ER

PT J
AU Kim, P
   Park, JH
   Kwon, KJ
   Kim, KC
   Kim, HJ
   Lee, JM
   Kim, HY
   Han, SH
   Shin, CY
AF Kim, Pitna
   Park, Jin Hee
   Kwon, Kyoung Ja
   Kim, Ki Chan
   Kim, Hee Jin
   Lee, Jong Min
   Kim, Hahn Young
   Han, Seol-Heui
   Shin, Chan Young
TI Effects of Korean red ginseng extracts on neural tube defects and
   impairment of social interaction induced by prenatal exposure to
   valproic acid
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Korean red ginseng; Autism spectrum disorder; Valproic acid; Social
   impairment; Crooked tail
ID AUTISM SPECTRUM DISORDERS; PANAX-GINSENG; STEM-CELLS; NEURONAL
   DIFFERENTIATION; PROGENITOR CELLS; BEHAVIORAL ALTERATIONS; SPINA-BIFIDA;
   GUINEA-PIGS; FOLIC-ACID; RATS
AB Ginseng is one of the most widely used medicinal plants, which belongs to the genus Panax. Compared to uncured white ginseng, red ginseng has been generally regarded to produce superior pharmacological effects with lesser side/adverse effects, which made it popular in a variety of formulation from tea to oriental medicine. Using the prenatal valproic acid (VPA)-injection model of autism spectrum disorder (ASD) in rats, which produces social impairrment and altered seizure susceptibility as in human ASD patients as well as mild neural tube defects like crooked tail phenotype, we examined whether chronic administration of red ginseng extract may rescue the social impairment and crooked tail phenotype in prenatally VPA-exposed rat offspring. VPA-induced impairment in social interactions tested using sociability and social preference paradigms as well as crooked tail phenotypes were significantly improved by administration of Korean red ginseng (KRG) in a dose dependent manner. Rat offspring prenatally exposed to VPA showed higher sensitivity to electric shock seizure and increased locomotor activity in open-field test. KRG treatment reversed abnormal locomotor activity and sensitivity to electric shock to control level. These results suggest that KRG may modulate neurobehavioral and structural organization of nervous system adversely affected by prenatal exposure to VPA. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Kim, Pitna; Park, Jin Hee; Kwon, Kyoung Ja; Kim, Ki Chan; Kim, Hee Jin; Lee, Jong Min; Kim, Hahn Young; Han, Seol-Heui; Shin, Chan Young] Konkuk Univ, Sch Med, Dept Neurosci, Seoul 143701, South Korea.
   [Kim, Pitna; Park, Jin Hee; Kwon, Kyoung Ja; Kim, Ki Chan; Kim, Hee Jin; Lee, Jong Min; Kim, Hahn Young; Han, Seol-Heui; Shin, Chan Young] Konkuk Univ, Neurosci Res Ctr, Inst SMART IABS, Seoul 143701, South Korea.
   [Shin, Chan Young] Konkuk Univ, Sch Med, Dept Pharmacol, Seoul 143701, South Korea.
   [Kim, Hee Jin] Sahmyook Univ, Coll Pharm, Dept Pharmacol, Seoul 139742, South Korea.
RP Shin, CY (reprint author), Konkuk Univ, Dept Pharmacol, Sch Med, 1 Hwayang Dong, Seoul 143701, South Korea.
EM chanyshin@kku.ac.kr
FU Korean Society of Ginseng; Korea Ginseng Corporation
FX This work was supported by the 2011 grant from The Korean Society of
   Ginseng funded by Korea Ginseng Corporation.
CR Balasubramaniyan V, 2006, NEUROSCIENCE, V143, P939, DOI 10.1016/j.neuroscience.2006.08.082
   BJERKEDAL T, 1982, LANCET, V2, P1096
   BROWNING RA, 1990, EPILEPSY RES, V6, P1, DOI 10.1016/0920-1211(90)90002-D
   Canitano R, 2007, EUR CHILD ADOLES PSY, V16, P61, DOI 10.1007/s00787-006-0563-2
   COPP AJ, 1989, J MED GENET, V26, P160, DOI 10.1136/jmg.26.3.160
   Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039
   Darius J, 1999, EUR J DRUG METAB PH, V24, P97
   Dawson JE, 2006, TOXICOL APPL PHARM, V211, P124, DOI 10.1016/j.taap.2005.07.008
   Doyle C.A., 2012, EXPERT OPIN PHARMACO
   Go HS, 2011, J BIOMED SCI, V18, DOI 10.1186/1423-0127-18-48
   Gurley BJ, 2002, CLIN PHARMACOL THER, V72, P276, DOI 10.1067/mcp.2002.126913
   Gurley BJ, 2005, DRUG AGING, V22, P525, DOI 10.2165/00002512-200522060-00006
   Hao YL, 2004, J NEUROSCI, V24, P6590, DOI 10.1523/JNEUROSCI.5747-03.2004
   Holst L, 2008, PHARMACOEPIDEM DR S, V17, P151, DOI 10.1002/pds.1527
   Hsieh J, 2004, P NATL ACAD SCI USA, V101, P16659, DOI 10.1073/pnas.0407643101
   Hwang SY, 2004, BJU INT, V94, P663, DOI 10.1111/j.1464-410X.2004.05019.x
   ITOH T, 1989, Planta Medica, V55, P429, DOI 10.1055/s-2006-962058
   Juliandi B, 2012, NEUROSCI RES, V72, P23, DOI 10.1016/j.neures.2011.09.012
   Jung GA, 2008, BMC CELL BIOL, V9, DOI 10.1186/1471-2121-9-66
   Kim JW, 2012, MATER LETT, V67, P11, DOI 10.1016/j.matlet.2011.09.028
   Kim KC, 2011, TOXICOL LETT, V201, P137, DOI 10.1016/j.toxlet.2010.12.018
   Kim SE, 2006, NEUROPSYCHOPHARMACOL, V31, P1714, DOI 10.1038/sj.npp.1300945
   Kim W, 1999, BJU INT, V83, P842
   Lee B, 2008, BIOL PHARM BULL, V31, P436, DOI 10.1248/bpb.31.436
   Lee B, 2011, J MICROBIOL BIOTECHN, V21, P1088, DOI 10.4014/jmb.1106.06027
   Lee HC, 2002, LIFE SCI, V71, P759, DOI 10.1016/S0024-3205(02)01742-3
   Lee JH, 2007, FOOD CHEM TOXICOL, V45, P2237, DOI 10.1016/j.fct.2007.05.019
   Lee JH, 2011, J ETHNOPHARMACOL, V133, P810, DOI 10.1016/j.jep.2010.11.020
   Lee Y.E., 2005, LAB ANIM RES, V21, P255
   Li HL, 2003, CHINESE MED J-PEKING, V116, P1776
   LITCHFIELD JT, 1949, J PHARMACOL EXP THER, V96, P99
   Liu JW, 2007, J NAT PROD, V70, P1329, DOI 10.1021/np070135j
   MINEMATSU S, 1990, FOLIA PHARMACOL JPN, V96, P265, DOI 10.1254/fpj.96.5_265
   Mitchell CP, 2005, J NEUROCHEM, V93, P483, DOI 10.1111/j.1471-4159.2005.03040.x
   Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x
   Murray MJ, 2010, CURR PSYCHIAT REP, V12, P382, DOI 10.1007/s11920-010-0145-3
   NAU H, 1982, BIOPHARM DRUG DISPOS, V3, P317, DOI 10.1002/bdd.2510030405
   Niederhofer Helmut, 2009, J Diet Suppl, V6, P342, DOI 10.3109/19390210903280231
   Noldus LPJJ, 2001, BEHAV RES METH INS C, V33, P398, DOI 10.3758/BF03195394
   Park HG, 2007, EUR J PHARMACOL, V574, P112, DOI 10.1016/j.ejphar.2007.07.011
   Park HM, 2012, FOOD CHEM TOXICOL, V50, P2736, DOI 10.1016/j.fct.2012.05.027
   Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040
   Qi LW, 2011, CURR DRUG METAB, V12, P818
   Schneider T, 2006, NEUROPSYCHOPHARMACOL, V31, P36, DOI 10.1038/sj.npp.1300767
   Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518
   Semmler A, 2012, TOXICOLOGY, V293, P132, DOI 10.1016/j.tox.2012.01.001
   Shen LH, 2004, NEUROL RES, V26, P422, DOI 10.1179/016164104225016047
   Shin S, 2010, BIRTH DEFECTS RES B, V89, P78, DOI 10.1002/bdrb.20224
   Si YC, 2011, AM J CHINESE MED, V39, P999, DOI 10.1142/S0192415X11009366
   SONODA T, 1990, Acta Paediatrica Japonica, V32, P502
   Tung EWY, 2010, TOXICOL APPL PHARM, V248, P201, DOI 10.1016/j.taap.2010.08.001
   Wang J, 2010, J ETHNOPHARMACOL, V132, P65, DOI 10.1016/j.jep.2010.07.042
   Wang L, 2011, J NEUROSCI METH, V194, P274, DOI 10.1016/j.jneumeth.2010.10.025
   Yizhar O, 2011, NATURE, V477, P171, DOI 10.1038/nature10360
   Yu CT, 2005, DRUG METAB DISPOS, V33, P19, DOI 10.1124/dmd.104.001917
   Yu IT, 2009, NEUROPHARMACOLOGY, V56, P473, DOI 10.1016/j.neuropharm.2008.09.019
   Zheng GQ, 2011, J ETHNOPHARMACOL, V133, P724, DOI 10.1016/j.jep.2010.01.064
   Zimmer B., 2012, ENV HLTH PERSPECT
NR 58
TC 7
Z9 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD JAN
PY 2013
VL 51
BP 288
EP 296
DI 10.1016/j.fct.2012.10.011
PG 9
WC Food Science & Technology; Toxicology
SC Food Science & Technology; Toxicology
GA 091VQ
UT WOS:000315078300036
PM 23104247
ER

PT J
AU Andersson, GW
   Miniscalco, C
   Johansson, U
   Gillberg, C
AF Andersson, Gunilla Westman
   Miniscalco, Carmela
   Johansson, Ulrika
   Gillberg, Christopher
TI Autism in Toddlers: Can Observation in Preschool Yield the Same
   Information as Autism Assessment in a Specialised Clinic?
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID DIAGNOSTIC OBSERVATION SCHEDULE; SPECTRUM DISORDERS; JOINT ATTENTION;
   CHILDREN; COMMUNICATION; MANAGEMENT
AB We wanted to know whether preschool observation of children suspected of suffering from autism can provide the same information about core autism symptoms as the Autism Diagnostic Observation Schedule (ADOS) performed in a clinic. Forty 2-4-year-old children (9 girls, 31 boys), referred for assessment of suspected autism spectrum disorder participated in the study. The symptom areas covered by the ADOS algorithm were scored by an education specialist after free-field observation of each child in the preschool without using the prescribed ADOS materials. The ADOS was then completed in a clinic setting by examiners blind to the preschool results. Excellent agreement across results obtained at the two different types/settings of observations was found. The only significant difference found was with regard to spontaneous initiation of joint attention. The present study does not address the issue of whether or not one of the methods used is superior to the other when it comes to determining the "true" level of "autism problems" in these children. However, it is of interest that free-field preschool observation of children with suspected autism using a structured checklist yields very similar information as that obtained at ADOS assessment performed in a clinic setting.
C1 [Andersson, Gunilla Westman; Miniscalco, Carmela; Gillberg, Christopher] Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, S-41119 Gothenburg, Sweden.
   [Johansson, Ulrika] Queen Silvia Childrens Hosp, S-41118 Gothenburg, Sweden.
RP Andersson, GW (reprint author), Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Kungsgatan 12, S-41119 Gothenburg, Sweden.
EM gunilla.andersson@gnc.gu.se
FU FoU-Committee in Gothenburg; South Bohuslan County Council; Annmari and
   Per Ahlqvist Foundation; theWilhelm and Martina Lundgren Foundation;
   Swedish Science Council [B41-f 1883/09]
FX The authors are grateful to the children, parents, and staff in
   preschools and at the CNC for their help and support at various stages
   of the study. The authors would also like to acknowledge the
   contributions of statistician Nils-Gunnar Pehrsson, Statistiska
   Konsultgruppen, and Jakob Asberg, Ph.D., Department of Psychology,
   University of Gothenburg, for support with the statistics. This study
   was supported by grants from the FoU-Committee in Gothenburg, South
   Bohuslan County Council, the Annmari and Per Ahlqvist Foundation,
   theWilhelm and Martina Lundgren Foundation, and from the Swedish Science
   Council (Grant no. B41-f 1883/09) for Christopher Gillberg.
CR Alin-Akerman B., 1991, GRIFFITHS DEV SCALES
   Altman D, 1991, PRACTICAL STAT MED R
   Andersson GW, 2013, RES DEV DISABIL, V34, P413, DOI 10.1016/j.ridd.2012.08.025
   Charman T, 2000, COGNITIVE DEV, V15, P481, DOI 10.1016/S0885-2014(01)00037-5
   Christensen L, 2010, J AUTISM DEV DISORD, V40, P946, DOI 10.1007/s10803-010-0941-y
   Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271
   Edwards S., 1997, REYNELL DEV LANGUAGE
   Eikeseth S, 2009, RES DEV DISABIL, V30, P158, DOI 10.1016/j.ridd.2008.02.003
   Eriksson M., 2002, INSTRUMENTS SCORING
   Fenson L., 1994, MACARTHUR COMMUNICAT
   Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Ingram DH, 2007, AUTISM, V11, P311, DOI 10.1177/1362361307078129
   Klintwall L, 2012, J AUTISM DEV DISORD, V42, P139, DOI 10.1007/s10803-011-1223-z
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   Nygren G., 2010, LAKARTIDNINGEN, P2314
   Pasco G, 2008, J AUTISM DEV DISORD, V38, P1807, DOI 10.1007/s10803-008-0569-3
   Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Swedish Council on Health Technology Assessment, 2012, PSYK DIAGN BEH SAMM
   Wechsler D, 1999, WECHLER PRESCHOOL PR
   Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023
   Wing L, 2011, RES DEV DISABIL, V32, P768, DOI 10.1016/j.ridd.2010.11.003
   Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606
NR 26
TC 2
Z9 2
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 384745
DI 10.1155/2013/384745
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 090EA
UT WOS:000314960800001
ER

PT J
AU Connolly, JJ
   Glessner, JT
   Hakonarson, H
AF Connolly, John J.
   Glessner, Joseph T.
   Hakonarson, Hakon
TI A Genome-Wide Association Study of Autism Incorporating Autism
   Diagnostic Interview-Revised, Autism Diagnostic Observation Schedule,
   and Social Responsiveness Scale
SO CHILD DEVELOPMENT
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; CORTICAL PYRAMIDAL NEURONS;
   COPY-NUMBER VARIATIONS; SPECTRUM DISORDERS; NEUROPSYCHIATRIC CONDITIONS;
   POTASSIUM CHANNELS; NUCLEUS-ACCUMBENS; CHILDREN; GENE; EXPRESSION
AB Efforts to understand the causes of autism spectrum disorders (ASDs) have been hampered by genetic complexity and heterogeneity among individuals. One strategy for reducing complexity is to target endophenotypes, simpler biologically based measures that may involve fewer genes and constitute a more homogenous sample. A genome-wide association study of 2,165 participants (mean age = 8.95 years) examined associations between genomic loci and individual assessment items from the Autism Diagnostic InterviewRevised, Autism Diagnostic Observation Schedule, and Social Responsiveness Scale. Significant associations with a number of loci were identified, including KCND2 (overly serious facial expressions), NOS2A (loss of motor skills), and NELL1 (faints, fits, or blackouts). These findings may help prioritize directions for future genomic efforts.
C1 [Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Abramson Res Ctr, Philadelphia, PA 19104 USA.
   [Hakonarson, Hakon] Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
RP Hakonarson, H (reprint author), Childrens Hosp Philadelphia, Ctr Appl Genom, Abramson Res Ctr, 1216E, Philadelphia, PA 19104 USA.
EM hakonarson@chop.edu
CR Alarcon M, 2005, MOL PSYCHIATR, V10, P747, DOI 10.1038/sj.mp.4001666
   Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005
   American Psychiatric Association, 2010, NEW PROP CHANG POST
   Anderson CA, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1000580
   Arcos-Burgos M, 2010, MOL PSYCHIATR, V15, P1053, DOI 10.1038/mp.2010.6
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Bekkers JM, 2000, J PHYSIOL-LONDON, V525, P593, DOI 10.1111/j.1469-7793.2000.t01-1-00593.x
   Bekkers JM, 2000, J PHYSIOL-LONDON, V525, P611, DOI 10.1111/j.1469-7793.2000.t01-2-00611.x
   Boraston Z, 2007, NEUROPSYCHOLOGIA, V45, P1501, DOI 10.1016/j.neuropsychologia.2006.11.010
   Bucan M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000536
   Butler MH, 1997, J CELL BIOL, V137, P1355, DOI 10.1083/jcb.137.6.1355
   Carney RM, 2003, PEDIATR NEUROL, V28, P205, DOI 10.1016/S0887-8994(02)00624-0
   Claeys KG, 2010, NEUROLOGY, V74, P519, DOI 10.1212/WNL.0b013e3181cef7f9
   Conciatori M, 2004, BIOL PSYCHIAT, V55, P413, DOI 10.1016/j.biopsych.2003.10.005
   Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212
   Constantino JN, 2007, J AM ACAD CHILD PSY, V46, P1668, DOI 10.1097/chi.0b013e318157cb23
   Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458
   Danielsson S, 2005, EPILEPSIA, V46, P918, DOI 10.1111/j.1528-1167.2005.57504.x
   de Bildt A, 2004, J AUTISM DEV DISORD, V34, P129
   De Giacomo A, 2009, NEUROPSYCH DIS TREAT, V5, P355
   Dickson SP, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000294
   Fecteau S, 2003, AUTISM, V7, P255, DOI 10.1177/1362361303007003003
   Ferreira MAR, 2008, NAT GENET, V40, P1056, DOI 10.1038/ng.209
   Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203
   Franke A, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000691
   Gepner B, 2009, NEUROSCI BIOBEHAV R, V33, P1227, DOI 10.1016/j.neubiorev.2009.06.006
   Geschwind DH, 2001, AM J HUM GENET, V69, P463, DOI 10.1086/321292
   Glessner JT, 2010, P NATL ACAD SCI USA, V107, P10584, DOI 10.1073/pnas.1000274107
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Glessner JT, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-9-236
   Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3
   Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1
   Gray KM, 2008, J AUTISM DEV DISORD, V38, P657, DOI 10.1007/s10803-007-0432-y
   Hoggart CJ, 2008, GENET EPIDEMIOL, V32, P179, DOI 10.1002/gepi.20292
   Hu VW, 2009, AUTISM RES, V2, P67, DOI 10.1002/aur.72
   Hu VW, 2009, AUTISM RES, V2, P78, DOI 10.1002/aur.73
   Isbrandt D, 2000, GENOMICS, V64, P144, DOI 10.1006/geno.2000.6117
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092
   Kelemenova S, 2009, NEUROENDOCRINOL LETT, V30, P429
   Kim HW, 2009, AM J MED GENET B, V150B, P300, DOI 10.1002/ajmg.b.30798
   Kim J, 2005, J PHYSIOL-LONDON, V569, P41, DOI 10.1113/physiol.2005.095042
   Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4
   Langen M, 2009, BIOL PSYCHIAT, V66, P327, DOI 10.1016/j.biopsych.2009.03.017
   Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x
   Lebrecht S, 2008, NEURON, V59, P841, DOI 10.1016/j.neuron.2008.09.007
   Liu JX, 2011, ACTA NEUROBIOL EXP, V71, P220
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Lord C., 2002, AUTISM DIAGNOSTIC OB
   Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   McCarthy MI, 2008, NAT REV GENET, V9, P356, DOI 10.1038/nrg2344
   Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90
   Moss J, 2008, J AUTISM DEV DISORD, V38, P1081, DOI 10.1007/s10803-007-0487-9
   Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7
   Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
   Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   Oguri M, 2010, AM J HYPERTENS, V23, P70, DOI 10.1038/ajh.2009.190
   Oosterling I, 2010, J AUTISM DEV DISORD, V40, P689, DOI 10.1007/s10803-009-0915-0
   Parmeggiani A, 2010, BRAIN DEV-JPN, V32, P783, DOI 10.1016/j.braindev.2010.07.003
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Piven J, 1997, AM J PSYCHIAT, V154, P185
   Price AL, 2006, NAT GENET, V38, P904, DOI 10.1038/ng1847
   Risch N, 1996, SCIENCE, V273, P1516, DOI 10.1126/science.273.5281.1516
   Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e
   Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Skuse DH, 2007, TRENDS GENET, V23, P387, DOI 10.1016/j.tig.2007.06.003
   Starr E, 2003, J AUTISM DEV DISORD, V33, P15, DOI 10.1023/A:1022222202970
   Sullivan PF, 2010, MOL PSYCHIATR, V15, P450, DOI 10.1038/mp.2009.106
   Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985
   Teslovich TM, 2010, NATURE, V466, P707, DOI 10.1038/nature09270
   Altshuler D, 2005, NATURE, V437, P1299, DOI 10.1038/nature04226
   Ting K, 1999, J BONE MINER RES, V14, P80, DOI 10.1359/jbmr.1999.14.1.80
   TUCHMAN RF, 1991, PEDIATRICS, V88, P1219
   VANENGELAND H, 1991, PSYCHIAT RES, V38, P27, DOI 10.1016/0165-1781(91)90050-Y
   Ventola P, 2007, J AUTISM DEV DISORD, V37, P425, DOI 10.1007/s10803-006-0177-z
   Viding E, 2007, BEHAV GENET, V37, P51, DOI 10.1007/s10519-006-9105-4
   Wallace DL, 2009, NAT NEUROSCI, V12, P200, DOI 10.1038/nn.2257
   Wang K, 2010, AM J HUM GENET, V86, P730, DOI 10.1016/j.ajhg.2010.04.003
   Wang K, 2010, NAT REV GENET, V11, P843, DOI 10.1038/nrg2884
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Warpeha KM, 2003, EYE, V17, P305, DOI 10.1038/sj.eye.6700348
   Yamagata M, 2008, NATURE, V451, P465, DOI 10.1038/nature06469
   Yonan AL, 2003, AM J HUM GENET, V73, P886, DOI 10.1086/378778
   Zhang XL, 2003, J BONE MINER RES, V18, P2126, DOI 10.1359/jbmr.2003.18.12.2126
   Zhang XL, 2002, J CLIN INVEST, V110, P861, DOI 10.1172/JCI200215375
   Zhu XR, 1999, RECEPTOR CHANNEL, V6, P387
NR 92
TC 10
Z9 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-3920
J9 CHILD DEV
JI Child Dev.
PD JAN-FEB
PY 2013
VL 84
IS 1
BP 17
EP 33
DI 10.1111/j.1467-8624.2012.01838.x
PG 17
WC Psychology, Educational; Psychology, Developmental
SC Psychology
GA 078PQ
UT WOS:000314112000002
PM 22935194
ER

PT J
AU Zhang, Y
   Haraksingh, R
   Grubert, F
   Abyzov, A
   Gerstein, M
   Weissman, S
   Urban, AE
AF Zhang, Ying
   Haraksingh, Rajini
   Grubert, Fabian
   Abyzov, Alexej
   Gerstein, Mark
   Weissman, Sherman
   Urban, Alexander E.
TI Child Development and Structural Variation in the Human Genome
SO CHILD DEVELOPMENT
LA English
DT Review
ID COPY-NUMBER VARIATION; AUTISM SPECTRUM DISORDERS; DEFICIT HYPERACTIVITY
   DISORDER; 22Q11.2 DELETION SYNDROME; SEGMENTAL DUPLICATIONS;
   WILLIAMS-SYNDROME; WIDE ANALYSIS; HUMAN-DISEASE; DE-NOVO; GENE
AB Structural variation of the human genome sequence is the insertion, deletion, or rearrangement of stretches of DNA sequence sized from around 1,000 to millions of base pairs. Over the past few years, structural variation has been shown to be far more common in human genomes than previously thought. Very little is currently known about the effects of structural variation on normal child development, but such effects could be of considerable significance. This review provides an overview of the phenomenon of structural variation in the human genome sequence, describing the novel genomics technologies that are revolutionizing the way structural variation is studied and giving examples of genomic structural variations that affect child development.
C1 [Zhang, Ying; Abyzov, Alexej; Gerstein, Mark; Weissman, Sherman] Yale Univ, New Haven, CT 06520 USA.
   [Urban, Alexander E.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Palo Alto, CA 94305 USA.
RP Urban, AE (reprint author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, 1050A Arastradero Rd,Room A233A, Palo Alto, CA 94305 USA.
EM aeurban@stanford.edu
RI Abyzov, Alexej/M-4284-2013
CR Abyzov A, 2011, BIOINFORMATICS, V27, P595, DOI 10.1093/bioinformatics/btq713
   Abyzov A, 2011, GENOME RES, V21, P974, DOI 10.1101/gr.114876.110
   Alkan C, 2009, NAT GENET, V41, P1061, DOI 10.1038/ng.437
   Alkan C, 2011, NAT REV GENET, V12, P363, DOI 10.1038/nrg2958
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Beaudet AL, 2013, CHILD DEV, V84, P121, DOI 10.1111/cdev.12050
   BONDESON ML, 1995, HUM MOL GENET, V4, P615, DOI 10.1093/hmg/4.4.615
   Brunetti-Pierri N, 2008, NAT GENET, V40, P1466, DOI 10.1038/ng.279
   Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133
   CHANCE PF, 1994, HUM MOL GENET, V3, P223, DOI 10.1093/hmg/3.2.223
   Chen K, 2009, NAT METHODS, V6, P677, DOI [10.1038/nmeth.1363, 10.1038/NMETH.1363]
   Chiang DY, 2009, NAT METHODS, V6, P99, DOI [10.1038/nmeth.1276, 10.1038/NMETH.1276]
   Conrad DF, 2010, NATURE, V464, P704, DOI 10.1038/nature08516
   ELIA J, 2012, NAT GENET, V44, P78, DOI DOI 10.1038/ng.1013
   Elia J, 2010, MOL PSYCHIATR, V15, P637, DOI 10.1038/mp.2009.57
   EWART AK, 1993, NAT GENET, V5, P11, DOI 10.1038/ng0993-11
   Francke U, 1978, Birth Defects Orig Artic Ser, V14, P191
   Glessner Joseph T, 2012, Curr Top Behav Neurosci, V12, P345, DOI 10.1007/7854_2011_179
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Gonzaga-Jauregui C, 2012, ANNU REV MED, V63, P35, DOI 10.1146/annurev-med-051010-162644
   Gonzalez E, 2005, SCIENCE, V307, P1434, DOI 10.1126/science.1101160
   Gothelf D, 2005, NAT NEUROSCI, V8, P1500, DOI 10.1038/nn1572
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Haraksingh RR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027859
   Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416
   Ionita-Laza I, 2009, GENOMICS, V93, P22, DOI 10.1016/j.ygeno.2008.08.012
   Iskow RC, 2010, CELL, V141, P1253, DOI 10.1016/j.cell.2010.05.020
   Itsara A, 2009, AM J HUM GENET, V84, P148, DOI 10.1016/j.ajhg.2008.12.014
   Jerome LA, 2001, NAT GENET, V27, P286, DOI 10.1038/85845
   Kasowski M, 2010, SCIENCE, V328, P232, DOI 10.1126/science.1183621
   Kidd JM, 2008, NATURE, V453, P56, DOI 10.1038/nature06862
   Kim PM, 2008, GENOME RES, V18, P1865, DOI 10.1101/gr.081422.108
   Klauck SM, 2006, EUR J HUM GENET, V14, P714, DOI 10.1038/sj.ejhg.5201610
   Korbel JO, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-2-r23
   Korbel JO, 2007, SCIENCE, V318, P420, DOI 10.1126/science.1149504
   Korbel JO, 2008, CURR OPIN STRUC BIOL, V18, P366, DOI 10.1016/j.sbi.2008.02.005
   Korbel JO, 2009, P NATL ACAD SCI USA, V106, P12031, DOI 10.1073/pnas.0813248106
   Kurotaki N, 2003, HUM MUTAT, V22, P378, DOI 10.1002/humu.10270
   Lam HYK, 2012, NAT BIOTECHNOL, V30, P226, DOI 10.1038/nbt.2134
   Lander ES, 2001, NATURE, V409, P860, DOI 10.1038/35057062
   Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137
   Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015
   Losh M, 2008, J NEUROPATH EXP NEUR, V67, P829, DOI 10.1097/NEN.0b013e318184482d
   Lupski JR, 2009, GENOME MED, V1, DOI 10.1186/gm42
   Marques-Bonet T, 2009, Cold Spring Harb Symp Quant Biol, V74, P355, DOI 10.1101/sqb.2009.74.011
   Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009
   McCarroll SA, 2008, NAT GENET, V40, P1166, DOI 10.1038/ng.238
   McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
   McDonald-McGinn DM, 2011, MEDICINE, V90, P1, DOI 10.1097/MD.0b013e3182060469
   Mefford HC, 2009, CURR OPIN GENET DEV, V19, P196, DOI 10.1016/j.gde.2009.04.003
   Merla G, 2010, HUM GENET, V128, P3, DOI 10.1007/s00439-010-0827-2
   Mills RE, 2006, GENOME RES, V16, P1182, DOI 10.1101/gr.4565806
   Mills RE, 2011, NATURE, V470, P59, DOI 10.1038/nature09708
   Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007
   Perry GH, 2007, NAT GENET, V39, P1256, DOI 10.1038/ng2123
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Redon R, 2006, NATURE, V444, P444, DOI 10.1038/nature05329
   Ritz A, 2010, BIOINFORMATICS, V26, P1291, DOI 10.1093/bioinformatics/btq153
   Roa B B, 1991, Int J Neurol, V25-26, P97
   Sachidanandam R, 2001, NATURE, V409, P928, DOI 10.1038/35057149
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Schatz DG, 2011, NAT REV IMMUNOL, V11, P251, DOI 10.1038/nri2941
   Schuster-Bockler B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009474
   Scriver C. R., 1989, METABOLIC BASIS INHE
   Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659
   Sebat J, 2004, SCIENCE, V305, P525, DOI 10.1126/science.1098918
   Shprintzen RJ, 2008, DEV DISABIL RES REV, V14, P3, DOI 10.1002/ddrr.2
   Stankiewicz P, 2010, ANNU REV MED, V61, P437, DOI 10.1146/annurev-med-100708-204735
   Stiles J, 2011, PROG BRAIN RES, V189, P3, DOI 10.1016/B978-0-444-53884-0.00015-4
   Taylor JG, 2001, TRENDS MOL MED, V7, P507, DOI 10.1016/S1471-4914(01)02183-9
   Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534
   Altshuler D, 2005, NATURE, V437, P1299, DOI 10.1038/nature04226
   Tom Strachan A. P. R., 2004, HUMAN MOL GENETICS, V3
   Tuzun E, 2005, NAT GENET, V37, P727, DOI 10.1038/ng1562
   Urban AE, 2006, P NATL ACAD SCI USA, V103, P4534, DOI 10.1073/pnas.0511340103
   Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050
   Vorstman JAS, 2009, NEUROPSYCHOPHARMACOL, V34, P739, DOI 10.1038/npp.2008.132
   Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974
   Williams NM, 2012, AM J PSYCHIAT, V169, P195, DOI 10.1176/appi.ajp.2011.11060822
   Williams NM, 2010, LANCET, V376, P1401, DOI 10.1016/S0140-6736(10)61109-9
   Ye K, 2009, BIOINFORMATICS, V25, P2865, DOI 10.1093/bioinformatics/btp394
   Zhang F, 2009, NAT GENET, V41, P849, DOI 10.1038/ng.399
   Zhang F, 2009, TRENDS GENET, V25, P298, DOI 10.1016/j.tig.2009.05.005
   Zhang H, 2002, MOL PSYCHIATR, V7, P1012, DOI 10.1038/sj.mp.4001124
   Zhang ZDD, 2011, BMC GENOMICS, V12, DOI 10.1186/1471-2164-12-375
NR 85
TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-3920
J9 CHILD DEV
JI Child Dev.
PD JAN-FEB
PY 2013
VL 84
IS 1
BP 34
EP 48
DI 10.1111/cdev.12051
PG 15
WC Psychology, Educational; Psychology, Developmental
SC Psychology
GA 078PQ
UT WOS:000314112000003
PM 23311762
ER

PT J
AU Hu, VW
AF Hu, Valerie W.
TI From Genes to Environment: Using Integrative Genomics to Build a
   "Systems-Level" Understanding of Autism Spectrum Disorders
SO CHILD DEVELOPMENT
LA English
DT Review
ID LYMPHOBLASTOID CELL-LINES; RECEPTOR ROR-ALPHA; FETAL VALPROATE SYNDROME;
   TRAIT LOCUS ANALYSIS; DEFICIENT MICE; RETT-SYNDROME; GASTROINTESTINAL
   SYMPTOMS; CEREBELLAR DEVELOPMENT; INFANTILE-AUTISM; DNA-METHYLATION
AB Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that affect an estimated 1 in 110 individuals. Although there is a strong genetic component associated with these disorders, this review focuses on the multifactorial nature of ASD and how different genome-wide (genomic) approaches contribute to our understanding of autism. Emphasis is placed on the need to study defined ASD phenotypes as well as to integrate large-scale omics data in order to develop a systems-level perspective of ASD, which in turn is necessary to allow predictions regarding responses to specific perturbations and interventions.
C1 George Washington Univ, Sch Med & Hlth Sci, Dept Biochem & Mol Biol, Washington, DC 20037 USA.
RP Hu, VW (reprint author), George Washington Univ, Sch Med & Hlth Sci, Dept Biochem & Mol Biol, 2300 Eye St NW, Washington, DC 20037 USA.
EM valhu@gwu.edu
CR Abu-Elneel K, 2008, NEUROGENETICS, V9, P153, DOI 10.1007/s10048-008-0133-5
   Akashi M, 2005, NAT STRUCT MOL BIOL, V12, P441, DOI 10.1038/nsmb925
   Alarcon M, 2005, MOL PSYCHIATR, V10, P747, DOI 10.1038/sj.mp.4001666
   American Psychiatric Association. DI, 1994, DIAGNOSTIC STAT MANU
   Amir RE, 2000, AM J MED GENET, V97, P147, DOI 10.1002/1096-8628(200022)97:2<147::AID-AJMG6>3.0.CO;2-O
   Anagnostou E, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-4
   [Anonymous], 2007, AM HERITAGE MED DICT
   Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
   Auyeung B, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-11
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Baron CA, 2006, J AUTISM DEV DISORD, V36, P973, DOI 10.1007/s10803-006-0134-x
   Benvenuto A., 2009, INT J PEDIAT, DOI [10.1155/2009/198736, DOI 10.1155/2009/198736]
   Bicker S, 2008, J CELL MOL MED, V12, P1466, DOI 10.1111/j.1582-4934.2008.00400.x
   BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
   Boukhtouche F, 2006, J NEUROCHEM, V96, P1778, DOI 10.1111/j.1471-4159.2006.03708.x
   Bradford Y, 2001, AM J MED GENET, V105, P539, DOI 10.1002/ajmg.1497
   Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007
   Chen GK, 2006, MOL PSYCHIATR, V11, P214, DOI 10.1038/sj.mp.4001753
   Chen X, 2009, DRUG DISCOV TODAY, V14, P754, DOI 10.1016/j.drudis.2009.05.005
   CHRISTIANSON AL, 1994, DEV MED CHILD NEUROL, V36, P361
   Chuang JC, 2007, PEDIATR RES, V61, p24R, DOI 10.1203/pdr.0b013e3180457684
   Cohly HHP, 2005, INT REV NEUROBIOL, V71, P317, DOI 10.1016/S0074-7742(05)71013-8
   Connolly J., CHILD DEV IN PRESS, VXX, pXXX
   Crawley JN, 2007, NEUROPEPTIDES, V41, P145, DOI 10.1016/j.npep.2007.02.002
   Delerive P, 2001, EMBO REP, V2, P42, DOI 10.1093/embo-reports/kve007
   Doulazmi M, 1999, J COMP NEUROL, V411, P267
   Dussault I, 1998, MECH DEVELOP, V70, P147, DOI 10.1016/S0925-4773(97)00187-1
   Duvall JA, 2007, AM J PSYCHIAT, V164, P656, DOI 10.1176/appi.ajp.164.4.656
   Fatemi SH, 2001, J AUTISM DEV DISORD, V31, P529, DOI 10.1023/A:1013234708757
   Fatemi SH, 2001, SYNAPSE, V42, P281, DOI 10.1002/syn.10002
   Feng J, 2009, INT REV NEUROBIOL, V89, P67, DOI 10.1016/S0074-7742(09)89004-1
   FENG Y, 1995, SCIENCE, V268, P731, DOI 10.1126/science.7732383
   Fiore R, 2008, BBA-GENE REGUL MECH, V1779, P471, DOI 10.1016/j.bbagrm.2007.12.006
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x
   Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009
   Gold DA, 2007, BRAIN RES, V1140, P19, DOI 10.1016/j.brainres.2005.11.080
   Gold DA, 2003, NEURON, V40, P1119, DOI 10.1016/S0896-6273(03)00769-4
   GOODALL G, 1987, BEHAV NEURAL BIOL, V47, P307, DOI 10.1016/S0163-1047(87)90422-5
   Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
   Grafodatskaya D, 2010, J AM ACAD CHILD PSY, V49, P794, DOI 10.1016/j.jaac.2010.05.005
   Gregg JP, 2008, GENOMICS, V91, P22, DOI 10.1016/j.ygeno.2007.09.003
   Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62
   Hadj-Sahraoui N, 2001, DEV BRAIN RES, V126, P201, DOI 10.1016/S0165-3806(01)00095-5
   Hallmayer J, 2002, AM J HUM GENET, V71, P941, DOI 10.1086/342990
   Harding HP, 1997, MOL ENDOCRINOL, V11, P1737, DOI 10.1210/me.11.11.1737
   Hawkins RD, 2010, NAT REV GENET, V11, P476, DOI 10.1038/nrg2795
   Hollander E, 2000, NEUROPSYCHOPHARMACOL, V22, P163, DOI 10.1016/S0893-133X(99)00121-9
   Hsieh J, 2010, NEUROBIOL DIS, V39, P73, DOI 10.1016/j.nbd.2010.01.008
   Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118
   Hu VW, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019067
   Hu VW, 2009, AUTISM RES, V2, P67, DOI 10.1002/aur.72
   Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775
   Hu VW, 2009, AUTISM RES, V2, P78, DOI 10.1002/aur.73
   Ingudomnuku E, 2007, HORM BEHAV, V51, P597, DOI 10.1016/j.yhbeh.2007.02.001
   Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001
   Johnson KP, 2008, CURR NEUROL NEUROSCI, V8, P155, DOI 10.1007/s11910-008-0025-y
   Jones MB, 2002, AM J MED GENET, V114, P558, DOI 10.1002/ajmg.10513
   Jyonouchi H, 2005, NEUROPSYCHOBIOLOGY, V51, P77, DOI 10.1159/000084164
   Kanner L, 1944, J PEDIATR-US, V25, P211, DOI 10.1016/S0022-3476(44)80156-1
   Kapsimali M, 2007, GENOME BIOL, V8, DOI 10.1186/gb-2007-8-8-r173
   Kelley R I, 2000, Adv Pediatr, V47, P1
   Kim SJ, 2000, HUM MUTAT, V15, P382, DOI 10.1002/(SICI)1098-1004(200004)15:4<382::AID-HUMU16>3.0.CO;2-8
   Kosik KS, 2006, NAT REV NEUROSCI, V7, P911, DOI 10.1038/nrn2037
   LALONDE R, 1987, J NEUROGENET, V4, P285, DOI 10.3109/01677068709102349
   Lalonde R, 2003, BEHAV GENET, V33, P59, DOI 10.1023/A:1021003600900
   Lander ES, 2001, NATURE, V409, P860, DOI 10.1038/35057062
   Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
   LeCouteur A, 1996, J CHILD PSYCHOL PSYC, V37, P785
   Lord C, 2001, AM J MED GENET, V105, P36, DOI 10.1002/1096-8628(20010108)105:1<36::AID-AJMG1053>3.0.CO;2-4
   Malow BA, 2004, MENT RETARD DEV D R, V10, P122, DOI 10.1002/mrdd.20023
   Martino S, 2009, J BIOMED BIOTECHNOL, DOI 10.1155/2009/654346
   Melin M, 2006, NEUROPSYCHOBIOLOGY, V54, P64, DOI 10.1159/000096040
   Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016
   Mill J, 2008, AM J HUM GENET, V82, P696, DOI 10.1016/j.ajhg.2008.01.008
   Minshew NJ, 2010, CURR OPIN NEUROL, V23, P124, DOI 10.1097/WCO.0b013e32833782d4
   Miyazaki K, 2005, INT J DEV NEUROSCI, V23, P287, DOI 10.1016/j.ijdevneu.2004.05.004
   Moore SJ, 2000, J MED GENET, V37, P489, DOI 10.1136/jmg.37.7.489
   Nagarajan RP, 2008, AUTISM RES, V1, P169, DOI 10.1002/aur.24
   Nguyen A, 2010, FASEB J, V24, P3036, DOI [10.1096/fj.10-154484, 10.1096/fj.09-154484]
   Nicholas B, 2007, MOL PSYCHIATR, V12, P581, DOI 10.1038/sj.mp.4001953
   Nilsen TW, 2007, TRENDS GENET, V23, P243, DOI 10.1016/j.tig.2007.02.011
   Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116
   Nurmi EL, 2003, J AM ACAD CHILD PSY, V42, P856, DOI 10.1097/01.CHI.0000046868.56865.0F
   Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287
   Pardo Carlos A, 2005, Int Rev Psychiatry, V17, P485, DOI 10.1080/02646830500381930
   Patterson PH, 2009, BEHAV BRAIN RES, V204, P313, DOI 10.1016/j.bbr.2008.12.016
   Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010
   Piven J, 2001, AM J MED GENET, V105, P34, DOI 10.1002/1096-8628(20010108)105:1<34::AID-AJMG1052>3.0.CO;2-D
   Purcell AE, 2001, NEUROLOGY, V57, P1618
   Rapin I, 2009, DEV NEUROPSYCHOL, V34, P66, DOI 10.1080/87565640802564648
   Rodier PM, 1997, REPROD TOXICOL, V11, P417, DOI 10.1016/S0890-6238(97)80001-U
   Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d
   Sarachana T, 2010, GENOME MED, V2, DOI 10.1186/gm144
   Sarachana T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017116
   Sato TK, 2004, NEURON, V43, P527, DOI 10.1016/j.neuron.2004.07.018
   Silverman JM, 2001, AM J MED GENET, V105, P593
   Smalley SL, 1998, J AUTISM DEV DISORD, V28, P407, DOI 10.1023/A:1026052421693
   Spence SJ, 2006, AM J MED GENET B, V141B, P591, DOI 10.1002/ajmg.b.30329
   Steinmayr M, 1998, P NATL ACAD SCI USA, V95, P3960, DOI 10.1073/pnas.95.7.3960
   Stevens MC, 2000, J AM ACAD CHILD PSY, V39, P346, DOI 10.1097/00004583-200003000-00017
   STROMLAND K, 1994, DEV MED CHILD NEUROL, V36, P351
   Tadevosyan-Leyfer O, 2003, J AM ACAD CHILD PSY, V42, P864, DOI 10.1097/01.CHI.0000046870.56865.90
   Takayanagi Y, 2005, P NATL ACAD SCI USA, V102, P16096, DOI 10.1073/pnas.0505312102
   Talebizadeh Z, 2008, AUTISM RES, V1, P240, DOI 10.1002/aur.33
   Tanguay PE, 1998, J AM ACAD CHILD PSY, V37, P271, DOI 10.1097/00004583-199803000-00011
   Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Venter JC, 2001, SCIENCE, V291, P1304, DOI 10.1126/science.1058040
   VOLKMAR FR, 1994, AM J PSYCHIAT, V151, P1361
   Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999
   Williams G, 2001, DEV MED CHILD NEUROL, V43, P202, DOI 10.1017/S001216220100038X
   Winslow JT, 2002, NEUROPEPTIDES, V36, P221, DOI 10.1054/npep.2002.0909
   Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013
   Yrigollen CM, 2008, BIOL PSYCHIAT, V63, P911, DOI 10.1016/j.biopsych.2007.11.015
   Van den Veyver IB, 2001, BRAIN DEV-JPN, V23, pS147, DOI 10.1016/S0387-7604(01)00376-X
NR 116
TC 7
Z9 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-3920
J9 CHILD DEV
JI Child Dev.
PD JAN-FEB
PY 2013
VL 84
IS 1
BP 89
EP 103
DI 10.1111/j.1467-8624.2012.01759.x
PG 15
WC Psychology, Educational; Psychology, Developmental
SC Psychology
GA 078PQ
UT WOS:000314112000007
PM 22497667
ER

PT J
AU Beaudet, AL
AF Beaudet, Arthur L.
TI The Utility of Chromosomal Microarray Analysis in Developmental and
   Behavioral Pediatrics
SO CHILD DEVELOPMENT
LA English
DT Review
ID COMPARATIVE GENOMIC HYBRIDIZATION; AUTISM SPECTRUM DISORDERS;
   COPY-NUMBER; ARRAY-CGH; MENTAL-RETARDATION; DE-NOVO;
   PSYCHIATRIC-DISORDERS; CLINICAL-SIGNIFICANCE; READING DIFFICULTIES;
   LANGUAGE IMPAIRMENT
AB Chromosomal microarray analysis (CMA) has emerged as a powerful new tool to identify genomic abnormalities associated with a wide range of developmental disabilities including congenital malformations, cognitive impairment, and behavioral abnormalities. CMA includes array comparative genomic hybridization (CGH) and single nucleotide polymorphism (SNP) arrays, both of which are useful for detection of genomic copy number variants (CNV) such as microdeletions and microduplications. The frequency of disease-causing CNVs is highest (20%25%) in children with moderate to severe intellectual disability accompanied by malformations or dysmorphic features. Disease-causing CNVs are found in 5%10% of cases of autism, being more frequent in severe phenotypes. CMA has replaced Giemsa-banded karyotype as the first-tier test for genetic evaluation of children with developmental and behavioral disabilities.
C1 Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
RP Beaudet, AL (reprint author), Baylor Coll Med, Dept Mol & Human Genet, 1 Baylor Plaza,BCM225, Houston, TX 77030 USA.
EM abeaudet@bcm.edu
CR American College of Obstetricians and Gynecologists, 2007, OBSTET GYNECOL, V110, P1459, DOI DOI 10.1097/01.AOG.0000291570.63450.44
   Astrom RL, 2007, TWIN RES HUM GENET, V10, P434, DOI 10.1375/twin.10.3.434
   Ballif BC, 2007, AM J MED GENET A, V143A, P1850, DOI 10.1002/ajmg.a.31842
   Ben-Shachar S, 2009, J MED GENET, V46, P382, DOI 10.1136/jmg.2008.064378
   Berg JS, 2007, GENET MED, V9, P427, DOI 10.1097/GIM.0b013e3180986192
   Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
   Bishop DVM, 2008, GENES BRAIN BEHAV, V7, P365, DOI 10.1111/j.1601-183X.2007.00360.x
   Boomsma DI, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010621
   Boone PM, 2010, HUM MUTAT, V31, P1326, DOI 10.1002/humu.21360
   Conlin LK, 2010, HUM MOL GENET, V19, P1263, DOI 10.1093/hmg/ddq003
   Conrad DF, 2010, NATURE, V464, P704, DOI 10.1038/nature08516
   Cooper GM, 2011, NAT GENET, V43, P838, DOI 10.1038/ng.909
   Coulter ME, 2011, GENET MED, V13, P770, DOI 10.1097/GIM.0b013e31821dd54a
   de Kovel CGF, 2010, BRAIN, V133, P23, DOI 10.1093/brain/awp262
   del Gaudio D, 2006, GENET MED, V8, P784, DOI 10.1097/01.gim.0000250502.28516.3c
   DeThorne LS, 2005, J SPEECH LANG HEAR R, V48, P792, DOI 10.1044/1092-4388(2005/055)
   Elia J, 2010, MOL PSYCHIATR, V15, P637, DOI 10.1038/mp.2009.57
   Ercan-Sencicek AG, 2010, NEW ENGL J MED, V362, P1901, DOI 10.1056/NEJMoa0907006
   Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P311, DOI 10.1007/s00787-010-0097-5
   Fruhman G, 2010, OBSTET GYN CLIN N AM, V37, P71, DOI 10.1016/j.ogc.2010.02.001
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Harris RA, 2004, LANCET, V363, P276, DOI 10.1016/S0140-6736(03)15385-8
   Hayiou-Thomas ME, 2005, J LEARN DISABIL-US, V38, P222, DOI 10.1177/00222194050380030401
   Helbig I, 2009, NAT GENET, V41, P160, DOI 10.1038/ng.292
   Hultman CM, 2011, MOL PSYCHIATR, V16, P1203, DOI 10.1038/mp.2010.121
   Jacquemont ML, 2006, J MED GENET, V43, P843, DOI 10.1136/jmg.2006.043166
   Jalal SM, 2003, GENET MED, V5, P28, DOI 10.1097/01.GIM.0000046363.02928.AE
   JANCAR J, 1990, J MENT DEFIC RES, V34, P483
   Kalra Veena, 2005, Indian Journal of Pediatrics, V72, P227, DOI 10.1007/BF02859263
   KNIGHT LA, 1995, J MED GENET, V32, P994, DOI 10.1136/jmg.32.12.994
   Lionel AC, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002464
   Lu XY, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000327
   Lu XY, 2008, PEDIATRICS, V122, P1310, DOI 10.1542/peds.2008-0297
   Malhotra D, 2012, CELL, V148, P1223, DOI 10.1016/j.cell.2012.02.039
   McCarthy SE, 2009, NAT GENET, V41, P1223, DOI 10.1038/ng.474
   Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
   Miles JH, 2011, GENET MED, V13, P278, DOI 10.1097/GIM.0b013e3181ff67ba
   Miller DT, 2010, AM J HUM GENET, V86, P749, DOI 10.1016/j.ajhg.2010.04.006
   Moeschler JB, 2006, PEDIATRICS, V117, P2304, DOI 10.1542/peds.2006-1006
   Narrow WE, 2002, ARCH GEN PSYCHIAT, V59, P115, DOI 10.1001/archpsyc.59.2.115
   Neill NJ, 2010, MOL CYTOGENET, V3, DOI 10.1186/1755-8166-3-11
   Oliver BR, 2007, TWIN RES HUM GENET, V10, P96, DOI 10.1375/twin.10.1.96
   O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835
   Ou Z, 2008, GENET MED, V10, P278, DOI 10.1097/GIM.0b013e31816b4420
   Park JH, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-102
   Ramocki MB, 2009, ANN NEUROL, V66, P771, DOI 10.1002/ana.21715
   Remschmidt H, 2005, J NEURAL TRANSM-SUPP, P121
   Roberts AE, 2004, AM J MED GENET A, V128A, P352, DOI 10.1002/ajmg.a.30142
   Rosenberg C, 2006, J MED GENET, V43, P180, DOI 10.1136/jmg.2005.032268
   Saha S, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000040
   Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002
   Schaaf CP, 2011, ANNU REV GENOM HUM G, V12, P25, DOI 10.1146/annurev-genom-092010-110715
   Schluth-Bolard C, 2009, EUR J MED GENET, V52, P291, DOI 10.1016/j.ejmg.2009.05.011
   Scott FJ, 2002, AUTISM, V6, P231, DOI 10.1177/1362361302006003002
   Sebat J, 2009, TRENDS GENET, V25, P528, DOI 10.1016/j.tig.2009.10.004
   Shaw-Smith C, 2004, J MED GENET, V41, P241, DOI 10.1136/jmg.2003.017731
   Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684
   Somerville MJ, 2005, NEW ENGL J MED, V353, P1694, DOI 10.1056/NEJMoa051962
   Stankiewicz P, 2007, CURR OPIN GENET DEV, V17, P182, DOI 10.1016/j.gde.2007.04.009
   State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004
   Stephen E, 2006, ARCH DIS CHILD, V91, P860, DOI 10.1136/adc.2006.100461
   Stewart LR, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-154
   Sundaram SK, 2010, NEUROLOGY, V74, P1583, DOI 10.1212/WNL.0b013e3181e0f147
   Szafranski P, 2010, HUM MUTAT, V31, P840, DOI 10.1002/humu.21284
   Van den Veyver IB, 2009, PRENATAL DIAG, V29, P29, DOI 10.1002/pd.2127
   Van der Aa N, 2009, EUR J MED GENET, V52, P94, DOI 10.1016/j.ejmg.2009.02.006
   Van Esch H, 2005, AM J HUM GENET, V77, P442, DOI 10.1086/444549
   Veltman JA, 2002, AM J HUM GENET, V70, P1269, DOI 10.1086/340426
   Vissers LELM, 2010, J MED GENET, V47, P289, DOI 10.1136/jmg.2009.072942
   Wadsworth SJ, 2005, TWIN RES HUM GENET, V8, P594, DOI 10.1375/183242705774860196
   Weiss LA, 2009, EXPERT REV MOL DIAGN, V9, P795, DOI [10.1586/erm.09.59, 10.1586/ERM.09.59]
   Williams J, 2006, J R SOC INTERFACE, V3, P399, DOI 10.1098/rsif.2005.0102
   Williams NM, 2010, LANCET, V376, P1401, DOI 10.1016/S0140-6736(10)61109-9
   Yu W, 2003, HUM MOL GENET, V12, P2145, DOI 10.1093/hmg/ddg230
   Yunis J. J., 1978, J CLIN PATHOL, V7, P267
NR 75
TC 8
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-3920
J9 CHILD DEV
JI Child Dev.
PD JAN-FEB
PY 2013
VL 84
IS 1
BP 121
EP 132
DI 10.1111/cdev.12050
PG 12
WC Psychology, Educational; Psychology, Developmental
SC Psychology
GA 078PQ
UT WOS:000314112000009
PM 23311723
ER

PT J
AU Isaksen, J
   Bryn, V
   Diseth, TH
   Heiberg, A
   Schjolberg, S
   Skjeldal, OH
AF Isaksen, Jorn
   Bryn, Vesna
   Diseth, Trond H.
   Heiberg, Arvid
   Schjolberg, Synnve
   Skjeldal, Ola H.
TI Children with autism spectrum disorders - The importance of medical
   investigations
SO EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
LA English
DT Article
DE Autism spectrum disorder; Medical conditions; Comorbidity
ID PERVASIVE DEVELOPMENTAL DISORDERS; BIRTH COMPLICATIONS; POPULATION;
   PREVALENCE; INDIVIDUALS; DIAGNOSIS
AB Background: Considerable knowledge about medical comorbidity in cases of Autism Spectrum Disorders (ASD) is available, still it is not well established how extensive the medical investigations should be in individual cases. The aim is to explore proportions of possible specific medical conditions in ASD.
   Methods: 79 subjects went through extensive medical evaluations according to pre-defined procedures, including medical and developmental history, physical and biomedical investigations.
   Results: Clinical neurological findings were quite common, and we found a high number of pathological findings in the additional medical investigations. Our study revealed that these pathological deviations occurred more frequently in patients with childhood autism than in the other diagnostic sub-groups, the exception were chromosomal findings which occurred more often in patients not-diagnosed with childhood autism.
   Conclusion: Medical and laboratory investigations should still be performed as a consequence of the patient's history, clinical presentations or family history. We should basically continue the use of non-routine and invasive procedures which do not put the patient at some unnecessary risk, in the absence of relevant clinical indications. (C) 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
C1 [Isaksen, Jorn] Innlandet Hosp Trust, Dept Habilitat, N-2609 Lillehammer, Norway.
   [Bryn, Vesna] Innlandet Hosp Trust, Hosp Lillehammer, Childrens Dept, N-2609 Lillehammer, Norway.
   [Diseth, Trond H.] Oslo Univ Hosp, Women & Childrens Div, Dept Clin Neurosci Children, Oslo, Norway.
   [Diseth, Trond H.] Univ Oslo, N-0316 Oslo, Norway.
   [Heiberg, Arvid] Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.
   [Schjolberg, Synnve] Norwegian Inst Publ Hlth, Div Mental Hlth, Trondheim, Norway.
   [Skjeldal, Ola H.] Vestre Viken Hosp Trust, Women & Childrens Clin, Drammen, Norway.
RP Isaksen, J (reprint author), Innlandet Hosp Trust, Dept Habilitat, Maihaugveien 4, N-2609 Lillehammer, Norway.
EM jorn.isaksen@sykehuset-innlandet.no
FU Innlandet Hospital Trust research foundation; Oslo University Hospital -
   Regional academic community for autism
FX The authors gratefully acknowledge the assistance of paediatrician Dr.
   Pernille Tryli, research nurses Janne Fossnes and, Bente Grondalen and
   research assistant Romain Mertz, and the rest of the diagnostic teams at
   CHS's at Ottestad and Lillehammer. This study was supported by Innlandet
   Hospital Trust research foundation and Oslo University Hospital -
   Regional academic community for autism.
CR Baieli S, 2003, J AUTISM DEV DISORD, V33, P201, DOI 10.1023/A:1022999712639
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Bauman ML, 2010, NEUROTHERAPEUTICS, V7, P320, DOI 10.1016/j.nurt.2010.06.001
   Benvenuto A, 2009, WORLD J PEDIATR, V5, P169, DOI 10.1007/s12519-009-0033-2
   Bergsjo P., 2007, NORSK EPIDEMIOLOGI, V17, P185
   Boddaert N, 2009, PLOS ONE, V4
   Brimacombe M, 2007, MATERN CHILD HLTH J, V11, P73, DOI 10.1007/s10995-006-0142-7
   Cederlund M, 2004, DEV MED CHILD NEUROL, V46, P652
   Cohen B., 1998, AUTISM, V2, P425, DOI 10.1177/1362361398024008
   Davis E, 2008, PSYCHIAT QUART, V79, P249, DOI 10.1007/s11126-008-9081-3
   Feinberg AP, 2010, VIRCHOWS ARCH, V456, P13, DOI 10.1007/s00428-009-0847-2
   Fombonne E, 1997, J AM ACAD CHILD PSY, V36, P1561, DOI 10.1016/S0890-8567(09)66566-7
   Gillberg C, 1998, J AUTISM DEV DISORD, V28, P415, DOI 10.1023/A:1026004505764
   Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618
   Gorker I, 2005, CRIT CARE CLIN, V21, P9
   Ijichi S, 2004, MED HYPOTHESES, V62, P188, DOI 10.1016/S0306-9877(03)00310-4
   Isaksen J, 2012, EUR J PAEDIAT NEUROL
   Jabourian A, 2011, ANN MED-PSYCHOL, V160, P421
   Jurecka A, 2009, J INHERIT METAB DIS, V32, P247, DOI 10.1007/s10545-009-1094-z
   Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006
   Kielinen M, 2000, EUR CHILD ADOLES PSY, V9, P162
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Lopez-Rangel E, 2006, CLIN GENET, V69, P21, DOI 10.1111/j.1399-0004.2006.00543a.x
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Miano Silvia, 2010, Paediatr Drugs, V12, P75, DOI 10.2165/11316140-000000000-00000
   Morris JK, 2008, EUR J HUM GENET, V16, P163, DOI 10.1038/sj.ejhg.5201956
   Oliveira G, 2005, DEV MED CHILD NEUROL, V47, P185, DOI 10.1017/S0012162205000332
   Rutter M, 2005, J INTELL DISABIL RES, V49, P231, DOI 10.1111/j.1365-2788.2005.00676.x
   RUTTER M, 1994, J CHILD PSYCHOL PSYC, V35, P311, DOI 10.1111/j.1469-7610.1994.tb01164.x
   Schiff M, 2010, ARCH PEDIATRIE, V17, P802, DOI 10.1016/S0929-693X(10)70119-6
   Schiff M., 2011, PLOS ONE, P6
   Shen Y, 2010, PEDIATRICS, V125, P725
   Sor-ost Helse, RETN DIAGN AUT
   Speer MC, 2003, J GENET COUNS, V12, P297, DOI 10.1023/A:1023948921381
   Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168
   Sponheim E, 1998, J AUTISM DEV DISORD, V28, P217, DOI 10.1023/A:1026017405150
   Steiner CE, 2003, ARQ NEURO-PSIQUIAT, V61, P176, DOI 10.1590/S0004-282X2003000200003
   Veltman MWM, 2005, PSYCHIAT GENET, V15, P243, DOI 10.1097/00041444-200512000-00006
   Williams JG, 2006, ARCH DIS CHILD, V91, P8, DOI 10.1136/adc.2004.062083
   Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0
   World Health Organisation (WHO), 2009, INT STAT CLASS DIS R, V10th
   World Health Organization, 1999, INT CLASS DIS 10 REV
   Ziats MN, 2011, PLOS ONE, V6
   Zwaigenbaum L, 2002, J AM ACAD CHILD PSY, V41, P572, DOI 10.1097/00004583-200205000-00015
NR 45
TC 3
Z9 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1090-3798
EI 1532-2130
J9 EUR J PAEDIATR NEURO
JI Eur. J. Paediatr. Neurol.
PD JAN
PY 2013
VL 17
IS 1
BP 68
EP 76
DI 10.1016/j.ejpn.2012.08.004
PG 9
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 081NU
UT WOS:000314329700011
PM 22954514
ER

PT J
AU Rucklidge, JJ
   Kaplan, BJ
AF Rucklidge, Julia J.
   Kaplan, Bonnie J.
TI Broad-spectrum micronutrient formulas for the treatment of psychiatric
   symptoms: a systematic review
SO EXPERT REVIEW OF NEUROTHERAPEUTICS
LA English
DT Review
DE ADHD; autism; depression; micronutrients; minerals; psychiatric;
   psychosis; review; treatment; vitamins
ID PLACEBO-CONTROLLED-TRIAL; RANDOMIZED CONTROLLED-TRIAL; YOUNG-ADULT
   PRISONERS; OPEN-LABEL TRIAL; BIPOLAR DISORDER; COGNITIVE FUNCTION;
   DOUBLE-BLIND; MENTAL-HEALTH; VITAMIN/MINERAL SUPPLEMENT; MITOCHONDRIAL
   DISEASE
AB Ingesting minerals and vitamins in combination makes physiological sense, and research on the use of broad-spectrum formulations for psychiatric symptoms is increasing rapidly. This review covers formulas consisting of at least four vitamins and/or minerals and includes four experimental designs: randomized controlled trials, open-label trials, case-control studies and case studies with within-subject crossovers. Nevertheless, there is evidence for the efficacy of micronutrients in the treatment of stress and antisocial behaviors as well as depressed mood in nonclinical and elderly populations. Many reports studied mood changes in healthy populations, making it difficult to generalize to clinical samples. There is also preliminary support for the treatment of autism with micronutrients. However, despite positive preliminary findings, there are less data available to support efficacy of micronutrient formulas in treating bipolar disorder, attention deficit-hyperactivity disorder and substance abuse/dependence and no clinical trials have been done with clinically depressed or anxious patient samples, psychosis or eating disorders.
C1 [Rucklidge, Julia J.] Univ Canterbury, Dept Psychol, Christchurch 1, New Zealand.
   [Kaplan, Bonnie J.] Univ Calgary, Dept Paediat, Calgary, AB T2N 1N4, Canada.
   [Kaplan, Bonnie J.] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada.
RP Rucklidge, JJ (reprint author), Univ Canterbury, Dept Psychol, Private Bag 4800, Christchurch 1, New Zealand.
EM julia.rucklidge@canterbury.ac.nz
FU Vic Davis Memorial Trust; University of Canterbury
FX JJ Rucklidge has received a private donation from Marie Lockie and
   research support from the Vic Davis Memorial Trust. The authors have no
   other relevant affiliations or financial involvement with any
   organization or entity with a financial interest in or financial
   conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed.JJ Rucklidge thanks the University
   of Canterbury for ongoing research support. BJ Kaplan thanks the Alberta
   Children's Hospital Research Institute for ongoing support. The authors
   thank Ellen Sole for help with compiling the tables.
CR Adams JB, 2011, BMC GASTROENTEROL, V11, DOI 10.1186/1471-230X-11-22
   Adams JB, 2004, J ALTERN COMPLEM MED, V10, P1033
   Adams JB, 2011, BMC PEDIATR, V11, DOI 10.1186/1471-2431-11-111
   Almeida OP, 2008, ARCH GEN PSYCHIAT, V65, P1286, DOI 10.1001/archpsyc.65.11.1286
   America A, 2008, J BEHAV MED, V31, P157, DOI 10.1007/s10865-007-9134-3
   Ames BN, 2002, AM J CLIN NUTR, V75, P616
   Amminger GP, 2010, ARCH GEN PSYCHIAT, V67, P146, DOI 10.1001/archgenpsychiatry.2009.192
   Arnold LE, 1999, J ATTEN DISORD, V3, P30, DOI 10.1177/108705479900300103
   Arvindakshan M, 2003, SCHIZOPHR RES, V62, P195, DOI 10.1016/S0920-9964(02)00284-0
   Australian Government Department of Health and Ageing Australia National Health and Medical Research Council, 2006, NUTR REF VAL AUSTR N
   Ayton AK, 2004, EUR PSYCHIAT, V19, P317, DOI 10.1016/j.eurpsy.2004.06.002
   BAN TA, 1977, COMMUN PSYCHOPHARMAC, V1, P119
   Benton D, 2013, MOL NUTR FOOD RES, V57, P6, DOI 10.1002/mnfr.201200477
   Benton D, 2007, NEUROSCI BIOBEHAV R, V31, P752, DOI 10.1016/j.neubiorev.2007.02.002
   BENTON D, 1995, NEUROPSYCHOBIOLOGY, V32, P98, DOI 10.1159/000119220
   Bjelakovic G, 2008, COCHRANE DB SYST REV, V2, DOI DOI 10.1002/14651858.CD007176
   Blampied NM, 2012, APA HDB BEHAV ANAL
   BLUM K, 1988, CURR THER RES CLIN E, V43, P1204
   BROWN RJ, 1990, J PSYCHOACTIVE DRUGS, V22, P173
   Carroll D, 2000, PSYCHOPHARMACOLOGY, V150, P220, DOI 10.1007/s002130000406
   Chen DY, 2012, J HUAZHONG U SCI-MED, V32, P422, DOI 10.1007/s11596-012-0073-z
   Chen K, 2011, NUTRITION, V27, P428, DOI 10.1016/j.nut.2010.04.004
   Chen TJH, 2011, J PSYCHOACTIVE DRUGS, V43, P108, DOI 10.1080/02791072.2011.587393
   Cockle SM, 2000, AGING MENT HEALTH, V4, P339
   Curtis LT, 2008, J ALTERN COMPLEM MED, V14, P79, DOI 10.1089/acm.2007.0610
   Duthie SJ, 2002, AM J CLIN NUTR, V75, P908
   Ford AH, 2012, J ALZHEIMERS DIS, V29, P133, DOI [10.3233/JAD-2012-111739, 10.3233/JAD-2011-111739]
   Forsythe P, 2010, BRAIN BEHAV IMMUN, V24, P9, DOI 10.1016/j.bbi.2009.05.058
   Frazier EA, 2009, J CHILD ADOL PSYCHOP, V19, P453, DOI 10.1089/cap.2008.0157
   Frazier EA, 2012, J ALTERN COMPLEM MED, V18, P678, DOI 10.1089/acm.2011.0270
   Frensham LJ, 2012, NUTR REV, V70, P594, DOI 10.1111/j.1753-4887.2012.00516.x
   Galler JR, 2012, J NUTR, V142, P788, DOI 10.3945/jn.111.145441
   Galler JR, 2010, J CHILD PSYCHOL PSYC, V51, P789, DOI 10.1111/j.1469-7610.2010.02208.x
   Gardner A, 2005, CURR PSYCHIAT REV, V1, P255, DOI 10.2174/157340005774575064
   Gariballa S, 2007, CLIN NUTR, V26, P545, DOI 10.1016/j.clnu.2007.06.007
   Gately D, 2009, CLIN MED PSYCHIAT, V4, P3
   Gesch CB, 2002, BRIT J PSYCHIAT, V181, P22, DOI 10.1192/bjp.181.1.22
   Gosney MA, 2008, GERONTOLOGY, V54, P292, DOI 10.1159/000131886
   Grima NA, 2012, J ALZHEIMERS DIS, V29, P561, DOI 10.3233/JAD-2011-111751
   Gruenwald J, 2002, ADV THER, V19, P141, DOI 10.1007/BF02850270
   Guenther RM, 1983, INT J BIOSOC RES, V4, P5
   Harding Karen L, 2003, Altern Med Rev, V8, P319
   Harris E, 2011, HUM PSYCHOPHARM CLIN, V26, P560, DOI 10.1002/hup.1245
   Harrison R, 2012, J PSYCHOACTIVE DRUGS, V32, P422
   Haskell CF, 2010, HUM PSYCHOPHARM CLIN, V25, P448, DOI 10.1002/hup.1144
   Haskell CF, 2008, BRIT J NUTR, V100, P1086, DOI 10.1017/S0007114508959213
   Henin A, 2009, J CLIN PSYCHIAT, V70, P1178, DOI 10.4088/JCP.08m04696
   HESEKER H, 1992, ANN N Y ACAD SCI, V669, P352
   Hoffer LJ, 2008, ISR J PSYCHIATR REL, V45, P3
   Huskisson E, 2007, J INT MED RES, V35, P1
   Jacka FN, 2010, AM J PSYCHIAT, V167, P305, DOI 10.1176/appi.ajp.2009.09060881
   Jackson JR, 2012, PSYCHIAT QUART, V83, P91, DOI 10.1007/s11126-011-9186-y
   JOSHI VG, 1980, J ORTHOMOL MED, V9, P35
   Jureidini JN, 2004, BRIT MED J, V328, P879, DOI 10.1136/bmj.328.7444.879
   Kaplan BJ, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-65
   Kaplan BJ, 2001, J CLIN PSYCHIAT, V62, P936
   Kaplan BJ, 2007, PSYCHOL BULL, V133, P747, DOI 10.1037/0033-2909.133.5.747
   Kaplan BJ, 2002, J CHILD ADOL PSYCHOP, V12, P205, DOI 10.1089/104454602760386897
   Kaplan BJ, 2004, J CHILD ADOL PSYCHOP, V14, P115, DOI 10.1089/104454604773840553
   Katz M, 2010, J ATTEN DISORD, V14, P281, DOI 10.1177/1087054709356388
   Kennedy DO, 2010, PSYCHOPHARMACOLOGY, V211, P55, DOI 10.1007/s00213-010-1870-3
   Knowles SR, 2008, BIOL PSYCHOL, V77, P132
   Kuijer RG, 2012, APPETITE, V58, P936, DOI 10.1016/j.appet.2012.02.046
   MacFabe DF, 2011, BEHAV BRAIN RES, V217, P47, DOI 10.1016/j.bbr.2010.10.005
   Manders M, 2009, J NUTR HEALTH AGING, V13, P760, DOI 10.1007/s12603-009-0211-x
   Martin A, 2004, ARCH PEDIAT ADOL MED, V158, P773, DOI 10.1001/archpedi.158.8.773
   McCreadie RG, 2005, BRIT J PSYCHIAT, V187, P346, DOI 10.1192/bjp.187.4.346
   McIntyre RS, 2008, ARCH PEDIAT ADOL MED, V162, P929, DOI 10.1001/archpedi.162.10.929
   McNally L, 2008, CNS SPECTRUMS, V13, P501
   Mehl-Madrona L, 2010, J CHILD ADOL PSYCHOP, V20, P95, DOI 10.1089/cap.2009.0011
   MERTZ W, 1994, J AM DIET ASSOC, V94, P1259, DOI 10.1016/0002-8223(94)92456-2
   Messaoudi M, 2011, BRIT J NUTR, V105, P755, DOI 10.1017/S0007114510004319
   Miller ER, 2005, ANN INTERN MED, V142, P37
   Moher D, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000097
   Molina BSG, 2009, J AM ACAD CHILD PSY, V48, P484, DOI 10.1097/CHI.0b013e31819c23d0
   NERI M, 1995, ARCH GERONTOL GERIAT, V21, P241, DOI 10.1016/0167-4943(95)00659-9
   Nguyen PH, 2009, ARCH LATINOAM NUTR, V59, P278
   Oddy WH, 2009, PREV MED, V49, P39, DOI 10.1016/j.ypmed.2009.05.009
   Parikh S, 2009, CURR TREAT OPTION N, V11, P414, DOI 10.1007/s11940-009-0046-0
   Popper CW, 2001, J CLIN PSYCHIAT, V62, P933
   POULOS CJ, 1981, J ORTHOMOL MED, V10, P61
   Remington R, 2009, AM J ALZHEIMERS DIS, V24, P27, DOI 10.1177/1533317508325094
   Ritter T, 1910, PEOPLES HOME MED BOO
   Rodway M, 2012, BMJ CASE REPORTS, Vpii, P1
   Rossignol DA, 2009, ANN CLIN PSYCHIATRY, V21, P213
   Rossignol DA, 2012, MOL PSYCHIATR, V17, P290, DOI 10.1038/mp.2010.136
   Rucklidge J, 2011, J ATTEN DISORD, V15, P79, DOI 10.1177/1087054709356173
   Rucklidge J, 2011, PSYCHIAT RES, V189, P281, DOI 10.1016/j.psychres.2011.06.016
   Rucklidge Julia J, 2009, Expert Rev Neurother, V9, P461, DOI 10.1586/ern.09.7
   Rucklidge JJ, 2010, BMC PSYCHIAT, V74
   Rucklidge JJ, 2010, CNS SPECTRUMS, V15, P289
   Rucklidge JJ, 2009, J ANXIETY DISORD, V23, P836, DOI 10.1016/j.janxdis.2009.02.012
   Rucklidge JJ, 2012, HUM PSYCHOPHARM CLIN, V27, P440, DOI 10.1002/hup.2246
   Russell Vivienne A, 2006, Behav Brain Funct, V2, P30, DOI 10.1186/1744-9081-2-30
   Sanchez-Villegas A, 2012, PUBLIC HEALTH NUTR, V15, P424, DOI 10.1017/S1368980011001856
   Sanchez-Villegas A, 2009, ARCH GEN PSYCHIAT, V66, P1090, DOI 10.1001/archgenpsychiatry.2009.129
   Sarris J, 2011, BIPOLAR DISORD, V13, P454, DOI 10.1111/j.1399-5618.2011.00945.x
   Sato Y, 2005, JAMA-J AM MED ASSOC, V293, P1082, DOI 10.1001/jama.293.9.1082
   Schlebusch L, 2000, S AFR MED J, V90, P1216
   Schoenthaler Stephen, 1997, Journal of Nutritional and Environmental Medicine (Abingdon), V7, P343, DOI 10.1080/13590849762475
   Schoenthaler SJ, 2000, J ALTERN COMPLEM MED, V6, P7, DOI 10.1089/acm.2000.6.7
   Simmons M, 2003, J CLIN PSYCHIAT, V64, P338
   Simmons M, 2003, J CLIN PSYCHIAT, V64, P339
   Simon GE, 2004, GEN HOSP PSYCHIAT, V26, P171, DOI 10.1016/j.genhosppsych.2004.01.002
   Simpson JSA, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-62
   Sinn N, 2007, J DEV BEHAV PEDIATR, V28, P82, DOI 10.1097/01.DBP.0000267558.88457.a5
   Stevenson J, 2010, AM J PSYCHIAT, V167, P1108, DOI 10.1176/appi.ajp.2010.09101529
   Stough C, 2011, HUM PSYCHOPHARM CLIN, V26, P470, DOI 10.1002/hup.1229
   Teaford MF, 2000, P NATL ACAD SCI USA, V97, P13506, DOI 10.1073/pnas.260368897
   Tonkin A, 2005, BRIT J PSYCHIAT, V187, P304, DOI 10.1192/bjp.187.4.304
   Vaughan K, 1999, AUST NZ J PSYCHIAT, V33, P84, DOI 10.1046/j.1440-1614.1999.00527.x
   Vazir S, 2006, NUTRITION, V22, pS26, DOI 10.1016/j.nut.2004.07.021
   Williams R. J., 1998, BIOCH INDIVIDUALITY
   Young LT, 2007, J PSYCHIATR NEUROSCI, V32, P160
   Zaalberg A, 2010, AGGRESSIVE BEHAV, V36, P117, DOI 10.1002/ab.20335
NR 115
TC 15
Z9 15
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
   ENGLAND
SN 1473-7175
J9 EXPERT REV NEUROTHER
JI Expert Rev. Neurother.
PD JAN
PY 2013
VL 13
IS 1
BP 49
EP 73
DI 10.1586/ERN.12.143
PG 25
WC Clinical Neurology; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 083BT
UT WOS:000314438400012
PM 23253391
ER

PT J
AU Botros, HG
   Legrand, P
   Pagan, C
   Bondet, V
   Weber, P
   Ben-Abdallah, M
   Lemiere, N
   Huguet, G
   Bellalou, J
   Maronde, E
   Beguin, P
   Haouz, A
   Shepard, W
   Bourgeron, T
AF Botros, Hany Goubran
   Legrand, Pierre
   Pagan, Cecile
   Bondet, Vincent
   Weber, Patrick
   Ben-Abdallah, Mariem
   Lemiere, Nathalie
   Huguet, Guillaume
   Bellalou, Jacques
   Maronde, Erik
   Beguin, Pierre
   Haouz, Ahmed
   Shepard, William
   Bourgeron, Thomas
TI Crystal structure and functional mapping of human ASMT, the last enzyme
   of the melatonin synthesis pathway
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE ASMT; Genetic variants; crystal structure; melatonin; O-methyl
   transferase
ID HYDROXYINDOLE-O-METHYLTRANSFERASE; AUTISM SPECTRUM DISORDERS; HUMAN
   PINEAL-GLAND; MOLECULAR REPLACEMENT; PROTEIN COMPLEXES; MUTATION; LIGHT;
   GENE
AB Melatonin is a synchronizer of many physiological processes. Abnormal melatonin signaling is associated with human disorders related to sleep, metabolism, and neurodevelopment. Here, we present the X-ray crystal structure of human N-acetyl serotonin methyltransferase (ASMT), the last enzyme of the melatonin biosynthesis pathway. The polypeptide chain of ASMT consists of a C-terminal domain, which is typical of other SAM-dependent O-methyltransferases, and an N-terminal domain, which intertwines several helices with another monomer to form the physiologically active dimer. Using radioenzymology, we analyzed 20 nonsynonymous variants identified through the 1000 genomes project and in patients with neuropsychiatric disorders. We found that the majority of these mutations reduced or abolished ASMT activity including one relatively frequent polymorphism in the Han Chinese population (N17K, rs17149149). Overall, we estimate that the allelic frequency of ASMT deleterious mutations ranges from 0.66% in Europe to 2.97% in Asia. Mapping of the variants on to the 3-dimensional structure clarifies why some are harmful and provides a structural basis for understanding melatonin deficiency in humans.
C1 [Botros, Hany Goubran; Pagan, Cecile; Lemiere, Nathalie; Huguet, Guillaume; Bourgeron, Thomas] Inst Pasteur, Human Genet & Cognit Funct Unit, F-75015 Paris, France.
   [Botros, Hany Goubran; Pagan, Cecile; Lemiere, Nathalie; Huguet, Guillaume; Bourgeron, Thomas] Inst Pasteur, CNRS, URA Genes Synapses & Cognit 2182, F-75015 Paris, France.
   [Botros, Hany Goubran; Pagan, Cecile; Lemiere, Nathalie; Huguet, Guillaume; Bourgeron, Thomas] Univ Paris Diderot, Paris, France.
   [Legrand, Pierre; Shepard, William] Synchrotron SOLEIL, F-91192 Gif Sur Yvette, France.
   [Botros, Hany Goubran; Pagan, Cecile; Bondet, Vincent; Ben-Abdallah, Mariem; Lemiere, Nathalie; Huguet, Guillaume; Bellalou, Jacques; Beguin, Pierre; Bourgeron, Thomas] Inst Pasteur, F-75015 Paris, France.
   [Weber, Patrick; Haouz, Ahmed; Shepard, William] Inst Pasteur, CNRS, UMR3528, F-75015 Paris, France.
   [Maronde, Erik] Goethe Univ Frankfurt, Inst Anat 3, D-60054 Frankfurt, Germany.
RP Bourgeron, T (reprint author), Inst Pasteur, 25 Rue Docteur Roux, F-75015 Paris, France.
EM william.shepard@synchrotron-soleil.fr; thomasb@pasteur.fr
FU Institut Pasteur; University Paris Diderot; CNRS; Fondation Orange; ANR
   [ANR-08-MNPS-037-01 - SynGen]; Neuron-ERANET; Fondation FondaMentale;
   Fondation Recherche Medicale; ESRF; Synchrotrons [20080516]
FX This work was supported by the Institut Pasteur, University Paris
   Diderot, CNRS, Fondation Orange, ANR (ANR-08-MNPS-037-01 - SynGen),
   Neuron-ERANET (EUHF-AUTISM), Fondation FondaMentale, Fondation Recherche
   Medicale, the ESRF and Synchrotrons (SOLEIL Proposal 20080516, ESRF at
   Grenoble).
CR AXELROD J, 1965, J BIOL CHEM, V240, P949
   Barnard AR, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.1000040
   Ben-Abdallah M, 2010, PROTEIN EXPRES PURIF, V75, P114
   BERNARD M, 1995, BRAIN RES, V696, P37, DOI 10.1016/0006-8993(95)00651-6
   Blanc E, 2004, ACTA CRYSTALLOGR D, V60, P2210, DOI 10.1107/S0907444904016427
   Chaste P, 2011, J PINEAL RES, V51, P394, DOI 10.1111/j.1600-079X.2011.00902.x
   Cowtan K, 2010, ACTA CRYSTALLOGR D, V66, P470, DOI 10.1107/S090744490903947X
   Cowtan K, 2006, ACTA CRYSTALLOGR D, V62, P1002, DOI 10.1107/S0907444906022116
   Cui FC, 2011, J COMPUT CHEM, V32, P3068, DOI 10.1002/jcc.21890
   DONOHUE SJ, 1993, DNA CELL BIOL, V12, P715, DOI 10.1089/dna.1993.12.715
   Emsley P, 2010, ACTA CRYSTALLOGR D, V66, P486, DOI 10.1107/S0907444910007493
   Hallam KT, 2006, PSYCHONEUROENDOCRINO, V31, P867, DOI 10.1016/j.psyneuen.2006.04.004
   Gibbs RA, 2003, NATURE, V426, P789, DOI 10.1038/nature02168
   Jonsson L, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-10
   Kabsch W, 2010, ACTA CRYSTALLOGR D, V66, P125, DOI 10.1107/S0907444909047337
   Krissinel E, 2007, J MOL BIOL, V372, P774, DOI 10.1016/j.jmb.2007.05.022
   Krissinel E, 2004, ACTA CRYSTALLOGR D, V60, P2256, DOI 10.1107/S0907444904026460
   Liu CJ, 2006, PLANT CELL, V18, P3656, DOI 10.1105/tpc.106.041376
   Maronde E, 2011, J PINEAL RES, V51, P145, DOI 10.1111/j.1600-079X.2011.00880.x
   Martin JL, 2002, CURR OPIN STRUC BIOL, V12, P783, DOI 10.1016/S0959-440X(02)00391-3
   McCoy AJ, 2007, ACTA CRYSTALLOGR D, V63, P32, DOI 10.1107/S0907444906045975
   Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016
   Obsil T, 2001, CELL, V105, P257, DOI 10.1016/S0092-8674(01)00316-6
   Pagan C, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-17
   Reiter RJ, 2010, PROG BRAIN RES, V181, P127, DOI 10.1016/S0079-6123(08)81008-4
   RODRIGUEZ IR, 1994, J BIOL CHEM, V269, P31969
   Santarsiero BD, 2002, J APPL CRYSTALLOGR, V35, P278, DOI 10.1107/S0021889802001474
   Schneider TR, 2002, ACTA CRYSTALLOGR D, V58, P1772, DOI 10.1107/S0907444902011678
   Shimomura K, 2010, P NATL ACAD SCI USA, V107, P8399, DOI 10.1073/pnas.1004368107
   Simonneaux V, 2003, PHARMACOL REV, V55, P325, DOI 10.1124/pr.55.2.2
   Stehle JH, 2011, J PINEAL RES, V51, P17, DOI 10.1111/j.1600-079X.2011.00856.x
   Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534
   Toma C, 2007, MOL PSYCHIATR, V12, P977, DOI 10.1038/sj.mp.4002069
   Vagin A, 2010, ACTA CRYSTALLOGR D, V66, P22, DOI 10.1107/S0907444909042589
   VIDGREN J, 1994, NATURE, V368, P354, DOI 10.1038/368354a0
   Zubieta C, 2002, PLANT CELL, V14, P1265, DOI 10.1105/tpc.001412
   Zubieta C, 2001, NAT STRUCT BIOL, V8, P271, DOI 10.1038/85029
NR 37
TC 6
Z9 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
J9 J PINEAL RES
JI J. Pineal Res.
PD JAN
PY 2013
VL 54
IS 1
BP 46
EP 57
DI 10.1111/j.1600-079X.2012.01020.x
PG 12
WC Endocrinology & Metabolism; Neurosciences; Physiology
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA 088PV
UT WOS:000314848500005
PM 22775292
ER

PT J
AU Chacon, MA
   Boulanger, LM
AF Chacon, Marcelo A.
   Boulanger, Lisa M.
TI MHC class I protein is expressed by neurons and neural progenitors in
   mid-gestation mouse brain
SO MOLECULAR AND CELLULAR NEUROSCIENCE
LA English
DT Article
DE MHCI; Neurodevelopment; Embryonic; Prenatal; Schizophrenia; Autism
ID MAJOR HISTOCOMPATIBILITY COMPLEX; EMBRYONIC STEM-CELLS; PED GENE;
   VISUAL-CORTEX; SYNAPTIC PLASTICITY; SUBVENTRICULAR ZONE; PRENATAL
   INFECTION; MATERNAL INFECTION; GENERATED NEURONS; CEREBRAL-CORTEX
AB Proteins of the major histocompatibility complex class I (MHCI) are known for their role in the vertebrate adaptive immune response, and are required for normal postnatal brain development and plasticity. However, it remains unknown if MHCI proteins are present in the mammalian brain before birth. Here, we show that MHCI proteins are widely expressed in the developing mouse central nervous system at mid-gestation (E9.5-10.5). MHCI is strongly expressed in several regions of the prenatal brain, including the neuroepithelium and olfactory placode. MHCI is expressed by neural progenitors at these ages, as identified by co-expression in cells positive for neuron-specific class III beta-tubulin (Tuj1) or for Pax6, a marker of neural progenitors in the dorsal neuroepithelium. MHCI is also co-expressed with nestin, a marker of neural stem/progenitor cells, in olfactory placode, but the co-localization is less extensive in other regions. MHCI is detected in the small population of post-mitotic neurons that are present at this early stage of brain development, as identified by co-expression in cells positive for neuronal microtubule-associated protein-2 (MAP2). Thus MHCI protein is expressed during the earliest stages of neuronal differentiation in the mammalian brain. MHCI expression in neurons and neural progenitors at mid-gestation, prior to the maturation of the adaptive immune system, is consistent with MHCI performing non-immune functions in prenatal brain development. These results raise the possibility that disruption of the levels and/or patterns of MHCI expression in the prenatal brain could contribute to the pathogenesis of neurodevelopmental disorders. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Boulanger, Lisa M.] Princeton Univ, Dept Mol Biol, Lewis Thomas Labs 123, Princeton, NJ 08544 USA.
   Princeton Univ, Princeton Neurosci Inst, Lewis Thomas Labs 123, Princeton, NJ 08544 USA.
RP Boulanger, LM (reprint author), Princeton Univ, Dept Mol Biol, Lewis Thomas Labs 123, Washington Rd, Princeton, NJ 08544 USA.
EM lboulang@princeton.edu
FU Princeton University; Autism Speaks; Whitehall Foundation; Alfred P.
   Sloan Foundation
FX We would like to thank Joe Goodhouse for his assistance with
   epifluorescence and confocal microscopy, and Dr. Jonathan Eggenschwiler
   for his critical comments on the manuscript. This study was supported by
   Princeton University startup funds and grants from Autism Speaks, the
   Whitehall Foundation, and the Alfred P. Sloan Foundation (L.M.B).
CR Atladottir HO, 2010, J AUTISM DEV DISORD, V40, P1423, DOI 10.1007/s10803-010-1006-y
   Bilousova T, 2012, J NEUROIMMUNOL, V247, P1, DOI 10.1016/j.jneuroim.2012.03.008
   Boksa P, 2010, BRAIN BEHAV IMMUN, V24, P881, DOI 10.1016/j.bbi.2010.03.005
   Bolteus AJ, 2004, J NEUROSCI, V24, P7623, DOI 10.1523/JNEUROSCI.1999-04.2004
   Boulanger LM, 2009, NEURON, V64, P93, DOI 10.1016/j.neuron.2009.09.001
   Brown AS, 2006, SCHIZOPHRENIA BULL, V32, P200, DOI 10.1093/schbul/sbj052
   Brunjes P C, 1986, Brain Res, V396, P1, DOI 10.1016/S0006-8993(86)80188-3
   BURGOYNE RD, 1988, EMBO J, V7, P2311
   CARRIERE C, 1995, CELL GROWTH DIFFER, V6, P1531
   Cheeran MCJ, 2008, J NEUROVIROL, V14, P437, DOI 10.1080/13550280802356845
   Chen ZG, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014787
   Cheyne JE, 2011, MOL CELL NEUROSCI, V47, P203, DOI 10.1016/j.mcn.2011.04.006
   CHUN JJM, 1989, J NEUROSCI, V9, P1648
   Corriveau RA, 1998, NEURON, V21, P505, DOI 10.1016/S0896-6273(00)80562-0
   Datwani A, 2009, NEURON, V64, P463, DOI 10.1016/j.neuron.2009.10.015
   Deverman BE, 2009, NEURON, V64, P61, DOI 10.1016/j.neuron.2009.09.002
   Doetsch F, 1997, J NEUROSCI, V17, P5046
   Dorfman JR, 1997, J IMMUNOL, V159, P5219
   Drukker M, 2002, P NATL ACAD SCI USA, V99, P9864, DOI 10.1073/pnas.142298299
   Elmer BM, 2012, TRENDS NEUROSCI, V35, P660, DOI 10.1016/j.tins.2012.08.001
   Escande-Beillard N, 2010, J IMMUNOL, V184, P816, DOI 10.4049/jimmunol.0902159
   Fehling HJ, 1997, CURR OPIN IMMUNOL, V9, P263, DOI 10.1016/S0952-7915(97)80146-X
   FERRI RT, 1993, CEREB CORTEX, V3, P187, DOI 10.1093/cercor/3.3.187
   Fourgeaud L, 2010, P NATL ACAD SCI USA, V107, P22278, DOI 10.1073/pnas.0914064107
   FUKUMOTO T, 1982, EUR J IMMUNOL, V12, P237, DOI 10.1002/eji.1830120313
   Garay Paula A, 2010, Front Synaptic Neurosci, V2, P136, DOI 10.3389/fnsyn.2010.00136
   Garay PA, BRAIN BEHAV IN PRESS
   Glynn MW, 2006, NAT PROTOC, V1, P1287, DOI 10.1038/nprot.2006.220
   Goddard CA, 2007, P NATL ACAD SCI USA, V104, P6828, DOI 10.1073/pnas.0702023104
   Goya RL, 2010, NEUROREPORT, V21, P349, DOI 10.1097/WNR.0b013e3283377463
   Hsieh YW, 2009, NEURAL DEV, V4, DOI 10.1186/1749-8104-4-32
   Huh GS, 2000, SCIENCE, V290, P2155, DOI 10.1126/science.290.5499.2155
   Ishii T, 2008, J NEUROSCI, V28, P2332, DOI 10.1523/JNEUROSCI.4807-07.2008
   Ishii T, 2003, CURR BIOL, V13, P394, DOI 10.1016/S0960-9822(03)00092-7
   KORNGUTH S, 1991, BIOCHEM BIOPH RES CO, V179, P102, DOI 10.1016/0006-291X(91)91340-I
   LEE MK, 1990, CELL MOTIL CYTOSKEL, V17, P118, DOI 10.1002/cm.970170207
   Leinders-Zufall T, 2004, SCIENCE, V306, P1033, DOI 10.1126/science.1102818
   LENDAHL U, 1990, CELL, V60, P585, DOI 10.1016/0092-8674(90)90662-X
   Li L, 2004, STEM CELLS, V22, P448, DOI 10.1634/stemcells.22-4-448
   Lidman O, 1999, EUR J NEUROSCI, V11, P4468, DOI 10.1046/j.1460-9568.1999.00904.x
   Linda H, 1998, EXP NEUROL, V150, P282, DOI 10.1006/exnr.1997.6768
   Loconto J, 2003, CELL, V112, P607, DOI 10.1016/S0092-8674(03)00153-3
   LUSKIN MB, 1985, J NEUROSCI, V5, P1062
   Luskin MB, 1998, J NEUROBIOL, V36, P221
   Madeja Z, 2011, P NATL ACAD SCI USA, V108, P4012, DOI 10.1073/pnas.1005342108
   Manuel M, 2005, BRAIN RES BULL, V66, P387, DOI 10.1016/j.brainresbull.2005..02.006
   MATUS A, 1988, ANNU REV NEUROSCI, V11, P29, DOI 10.1146/annurev.neuro.11.1.29
   McConnell MJ, 2009, P NATL ACAD SCI USA, V106, P6784, DOI 10.1073/pnas.0902018106
   MEMBERG SP, 1995, J NEUROBIOL, V27, P26, DOI 10.1002/neu.480270104
   Miralves J, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001354
   Mishra R, 2002, J BIOL CHEM, V277, P49488, DOI 10.1074/jbc.M206478200
   Needleman LA, 2010, P NATL ACAD SCI USA, V107, P16999, DOI 10.1073/pnas.1006087107
   Needleman LA, 2012, DEV NEUROBIOL, V72, P1288, DOI 10.1002/dneu.22046
   NEEFJES JJ, 1993, CURR OPIN IMMUNOL, V5, P27, DOI 10.1016/0952-7915(93)90077-6
   NEUMANN H, 1995, SCIENCE, V269, P549, DOI 10.1126/science.7624779
   OHNO S, 1977, IMMUNOL REV, V33, P59, DOI 10.1111/j.1600-065X.1977.tb00362.x
   Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
   Popa N, 2011, GLIA, V59, P35, DOI 10.1002/glia.21074
   Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
   RALL GF, 1995, J EXP MED, V182, P1201, DOI 10.1084/jem.182.5.1201
   Ribic A, 2011, BEHAV BRAIN FUNCT, V7, DOI 10.1186/1744-9081-7-1
   Richardson L, 2010, NUCLEIC ACIDS RES, V38, pD703, DOI 10.1093/nar/gkp763
   Rolleke U, 2006, J NEUROIMMUNOL, V176, P39, DOI 10.1016/j.jneuroim.2006.04.015
   Sasada T, 2003, EUR J IMMUNOL, V33, P368, DOI 10.1002/immu.200310011
   SCHMAHL W, 1993, ACTA NEUROPATHOL, V86, P126
   Shatz CJ, 2009, NEURON, V64, P40, DOI 10.1016/j.neuron.2009.09.044
   Soumiya H, 2011, J NEUROSCI RES, V89, P1575, DOI 10.1002/jnr.22704
   Stefansson H, 2009, NATURE, V460, P744, DOI 10.1038/nature08186
   Thams S, 2008, BRAIN RES REV, V57, P265, DOI 10.1016/j.brainresrev.2007.06.016
   TIAN Z, 1992, BIOL REPROD, V47, P271, DOI 10.1095/biolreprod47.2.271
   Torres AR, 2006, HUM IMMUNOL, V67, P346, DOI 10.1016/j.humimm.2006.01.001
   WALTHER C, 1991, DEVELOPMENT, V113, P1435
   WARNER CM, 1987, BIOL REPROD, V36, P611, DOI 10.1095/biolreprod36.3.611
   Washburn LR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018439
   WONG GHW, 1984, NATURE, V310, P688, DOI 10.1038/310688a0
   Wu LZ, 1999, BIOL REPROD, V60, P1114, DOI 10.1095/biolreprod60.5.1114
   Wu ZP, 2011, IMMUNOL LETT, V135, P118, DOI 10.1016/j.imlet.2010.10.011
   XU YX, 1994, BIOL REPROD, V51, P695, DOI 10.1095/biolreprod51.4.695
   Yin L, 2008, STEM CELLS DEV, V17, P53, DOI 10.1089/scd.2007.0063
   Zhang XQ, 2010, CELL STEM CELL, V7, P90, DOI 10.1016/j.stem.2010.04.017
   Zhang YH, 1998, MECH DEVELOP, V78, P179, DOI 10.1016/S0925-4773(98)00171-3
   ZIJLSTRA M, 1989, NATURE, V342, P435, DOI 10.1038/342435a0
   Zohar O, 2008, J IMMUNOL, V180, P6447
NR 83
TC 10
Z9 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1044-7431
J9 MOL CELL NEUROSCI
JI Mol. Cell. Neurosci.
PD JAN
PY 2013
VL 52
BP 117
EP 127
DI 10.1016/j.mcn.2012.11.004
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 085LB
UT WOS:000314615200012
PM 23147111
ER

PT J
AU Brown, EC
   Wiersema, JR
   Pourtois, G
   Brune, M
AF Brown, E. C.
   Wiersema, Jan Roelf
   Pourtois, Gilles
   Bruene, Martin
TI Modulation of motor cortex activity when observing rewarding and
   punishing actions
SO NEUROPSYCHOLOGIA
LA English
DT Article
DE Action observation; Reward; Punishment; Observational learning; Mirror
   neurons
ID SOCIAL COGNITION; PREMOTOR CORTEX; MIRROR NEURONS; MU-SUPPRESSION; EEG;
   SCHIZOPHRENIA; PERSPECTIVE; SYSTEM; AUTISM; RECOGNITION
AB Interpreting others' actions is essential for understanding the intentions and goals in social interactions. Activity in the motor cortex is evoked when we see another person performing actions, which can also be influenced by the intentions and context of the observed action. No study has directly explored the influence of reward and punishment on motor cortex activity when observing others' actions, which is likely to have substantial relevance in different social contexts. In this experiment, EEG was recorded while participants watched movie clips of a person performing actions that led to a monetary reward, loss or no change for the observer. Using the EEG mu rhythm as an index of motor resonance, our results demonstrate that observation of rewarding actions produce significantly greater motor cortex activity than punishing or neutral actions, with punishing actions producing greater activity than neutral ones. In addition, the dynamic change in the mu rhythm over sensorimotor cortex is modulated by reward and punishment, with punishing actions producing a prolonged suppression. These findings demonstrate that the associated reward value of an observed action may be crucial in determining the strength of the representation of the action in the observer's brain. Consequently, reward and punishment is likely to drive observational learning through changes in the action observation network, and may also influence how we interpret, understand, engage in and empathize with others' actions in social interaction. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Brown, E. C.; Bruene, Martin] LWL Univ Hosp Bochum, Res Dept Cognit Neuropsychiat, D-44791 Bochum, Germany.
   [Brown, E. C.; Bruene, Martin] Ruhr Univ Bochum, IGSN, D-44801 Bochum, Germany.
   [Wiersema, Jan Roelf; Pourtois, Gilles] Univ Ghent, Dept Expt Clin & Hlth Psychol, B-9000 Ghent, Belgium.
RP Brown, EC (reprint author), LWL Univ Hosp Bochum, Res Dept Cognit Neuropsychiat, Alexandrinenstr 1-3, D-44791 Bochum, Germany.
EM elliot.c.brown@gmail.com
RI Brown, Elliot/I-8137-2012
OI Brown, Elliot/0000-0002-0209-3293
FU International Brain Research Organisation (IBRO)-CEERC-WERC InEurope
   Travel Fellowship; European Research Council [200758]; Ghent University
   (BOF) [05Z01708]
FX This study was supported by an International Brain Research Organisation
   (IBRO)-CEERC-WERC InEurope Travel Fellowship granted to the author ECB.
   The author GP is supported by grants from the European Research Council
   (Starting Grant #200758) and Ghent University (BOF Grant #05Z01708).
CR Arbib MA, 2005, NEUROPSYCHOLOGIA, V43, P268, DOI 10.1016/j.neuropsychologia.2004.11.013
   Arnstein D, 2011, J NEUROSCI, V31, P14243, DOI 10.1523/JNEUROSCI.0963-11.2011
   Bandura A., 1977, SOCIAL LEARNING THEO
   Blakemore SJ, 2005, NEUROPSYCHOLOGIA, V43, P260, DOI 10.1016/j.neuropsychologia.2004.11.012
   Buccino G, 2008, CURR OPIN PSYCHIATR, V21, P281, DOI 10.1097/YCO.0b013e3282fbcd32
   Dichter GS, 2012, J AUTISM DEV DISORD, V42, P147, DOI 10.1007/s10803-011-1221-1
   Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002
   Gallese V, 2003, PHILOS T R SOC B, V358, P517, DOI 10.1098/rstb.2002.1234
   Gallese V, 1996, BRAIN, V119, P593, DOI 10.1093/brain/119.2.593
   Gold JM, 2008, SCHIZOPHRENIA BULL, V34, P835, DOI 10.1093/schbul/sbn068
   GUDYKUNST WB, 1992, J CROSS CULT PSYCHOL, V23, P196, DOI 10.1177/0022022192232005
   Hari R, 2006, PROG BRAIN RES, V159, P253, DOI 10.1016/S0079-6123(06)59017-X
   Jeannerod M, 2008, SOC NEUROSCI, V3, P356, DOI 10.1080/17470910701563715
   Keysers C, 2006, PROG BRAIN RES, V156, P379, DOI 10.1016/S0079-6123(06)56021-2
   Kilner JM, 2006, SOC COGN AFFECT NEUR, V1, P143, DOI 10.1093/scan/nsl017
   Koban L, 2010, SOC NEUROSCI-UK, V5, P360, DOI 10.1080/17470911003651547
   Krach S, 2010, FRONT BEHAV NEUROSCI, V4, DOI 10.3389/fnbeh.2010.00022
   Libby LK, 2009, J EXP PSYCHOL GEN, V138, P503, DOI 10.1037/a0016795
   Liew SL, 2010, HUM BRAIN MAPP, V32, P1986
   McCormick LM, 2012, PSYCHIAT RES-NEUROIM, V201, P233, DOI 10.1016/j.pscychresns.2012.01.004
   Mitchell JP, 2009, PHILOS T R SOC B, V364, P1309, DOI 10.1098/rstb.2008.0318
   Mukamel R, 2010, CURR BIOL, V20, P750, DOI 10.1016/j.cub.2010.02.045
   Oberman L. M., 2012, SOCIAL COGNITIVE AFF
   Oberman LM, 2005, COGNITIVE BRAIN RES, V24, P190, DOI 10.1016/j.cogbrainres.2005.01.014
   OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4
   Perry A, 2010, COGN AFFECT BEHAV NE, V10, P493, DOI 10.3758/CABN.10.4.493
   Perry A, 2010, SOC NEUROSCI-UK, V5, P272, DOI 10.1080/17470910903395767
   Perry A, 2011, NEUROIMAGE, V58, P895, DOI 10.1016/j.neuroimage.2011.06.060
   Pineda JA, 2009, BIOL PSYCHOL, V80, P306, DOI 10.1016/j.biopsycho.2008.11.003
   Press C, 2011, J NEUROSCI, V31, P2792, DOI 10.1523/JNEUROSCI.1595-10.2011
   Raymaekers R, 2009, BRAIN RES, V1304, P113, DOI 10.1016/j.brainres.2009.09.068
   Rizzolatti G, 1996, COGNITIVE BRAIN RES, V3, P131, DOI 10.1016/0926-6410(95)00038-0
   Rizzolatti G, 2001, NAT REV NEUROSCI, V2, P661, DOI 10.1038/35090060
   Schuch S, 2010, EXP BRAIN RES, V205, P235, DOI 10.1007/s00221-010-2358-4
   Schultz W, 2000, NAT REV NEUROSCI, V1, P199, DOI 10.1038/35044563
   Scott-Van Zeeland A. A., 2010, AUTISM RES OFFICIAL, V3, P53
   Singh F, 2011, SCHIZOPHR RES, V130, P182, DOI 10.1016/j.schres.2011.04.004
   Sobhani M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046809
   Tager-Flusberg H, 2000, COGNITION, V76, P59, DOI 10.1016/S0010-0277(00)00069-X
   Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8
   Woodruff CC, 2011, NEUROREPORT, V22, P744, DOI 10.1097/WNR.0b013e32834ab439
   Woodruff CC, 2011, BRAIN RES, V1405, P69, DOI 10.1016/j.brainres.2011.05.046
NR 42
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3932
J9 NEUROPSYCHOLOGIA
JI Neuropsychologia
PD JAN
PY 2013
VL 51
IS 1
BP 52
EP 58
DI 10.1016/j.neuropsychologia.2012.11.005
PG 7
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 083US
UT WOS:000314491300006
PM 23159701
ER

PT J
AU Sucksmith, E
   Allison, C
   Baron-Cohen, S
   Chakrabarti, B
   Hoekstra, RA
AF Sucksmith, E.
   Allison, C.
   Baron-Cohen, S.
   Chakrabarti, B.
   Hoekstra, R. A.
TI Empathy and emotion recognition in people with autism, first-degree
   relatives, and controls
SO NEUROPSYCHOLOGIA
LA English
DT Article
DE Autism; Empathy; Emotion; Broader autism phenotype; Endophenotype
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; SPECTRUM DISORDERS;
   COGNITIVE PHENOTYPE; SEX-DIFFERENCES; BASIC EMOTIONS; CHILDREN;
   QUOTIENT; PERCEPTION; INFORMATION
AB Empathy is the lens through which we view others' emotion expressions, and respond to them. In this study, empathy and facial emotion recognition were investigated in adults with autism spectrum conditions (ASC; N=314), parents of a child with ASC (N=297) and IQ-matched controls (N = 184). Participants completed a self-report measure of empathy (the Empathy Quotient [EQ]) and a modified version of the Karolinska Directed Emotional Faces Task (KDEF) using an online test interface. Results showed that mean scores on the EQ were significantly lower in fathers (p < 0.05) but not mothers (p > 0.05) of children with ASC compared to controls, whilst both males and females with ASC obtained significantly lower EQ scores (p < 0.001) than controls. On the KDEF, statistical analyses revealed poorer overall performance by adults with ASC (p < 0.001) compared to the control group. When the 6 distinct basic emotions were analysed separately, the ASC group showed impaired performance across five out of six expressions (happy, sad, angry, afraid and disgusted). Parents of a child with ASC were not significantly worse than controls at recognising any of the basic emotions, after controlling for age and non-verbal IQ (all p > 0.05). Finally, results indicated significant differences between males and females with ASC for emotion recognition performance (p < 0.05) but not for self-reported empathy (p > 0.05). These findings suggest that self-reported empathy deficits in fathers of autistic probands are part of the 'broader autism phenotype'. This study also reports new findings of sex differences amongst people with ASC in emotion recognition, as well as replicating previous work demonstrating empathy difficulties in adults with ASC. The use of empathy measures as quantitative endophenotypes for ASC is discussed. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Sucksmith, E.; Hoekstra, R. A.] Open Univ, Dept Life Hlth & Chem Sci, Milton Keynes MK7 6AA, Bucks, England.
   [Allison, C.; Baron-Cohen, S.; Chakrabarti, B.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Chakrabarti, B.] Univ Reading, Ctr Integrat Neurosci & Neurodynam, Sch Psychol & Clin Language Sci, Reading, Berks, England.
RP Sucksmith, E (reprint author), Open Univ, Dept Life Hlth & Chem Sci, Milton Keynes MK7 6AA, Bucks, England.
EM E.Sucksmith@open.ac.uk
FU Open University; MRC UK; Wellcome Trust
FX ES was supported by a PhD studentship from the Open University. SBC was
   supported by the MRC UK and the Wellcome Trust during the period of this
   study. BC is supported by the MRC UK. The study was conducted in
   association with the NIHR CLAHRC for NHS Cambridgeshire and Peterborough
   Foundation Trust. Preliminary data for this work was presented at the
   International Meeting for Autism Research, San Diego 2011. We are
   extremely grateful to all participants that took part.
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
   Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289
   Allison C, 2011, PERS INDIV DIFFER, V51, P829, DOI 10.1016/j.paid.2011.07.005
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Ashwin C, 2006, SOC NEUROSCI, V1, P349, DOI 10.1080/17470910601040772
   BARONCOHEN S, 1987, BRIT J DEV PSYCHOL, V5, P139
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548
   Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x
   Baron-Cohen S., 1995, MINDBLINDESS ESSAY A
   Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00
   Baron-Cohen S., 1996, J COGNITIVE NEUROSCI, V8, P400
   Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6
   BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8
   Bartels M, 2007, PSYCHOL METHODS, V12, P451, DOI 10.1037/1082-989X.12.4.451
   Belmonte MK, 2010, J CHILD PSYCHOL PSYC, V51, P259, DOI 10.1111/j.1469-7610.2009.02153.x
   Bolte S, 2003, PSYCHOL MED, V33, P907, DOI 10.1017/S0033291703007438
   Bolte S, 2011, AUTISM, V15, P497, DOI 10.1177/1362361310391116
   BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
   Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27
   Calder AJ, 2003, NEUROPSYCHOLOGIA, V41, P195, DOI 10.1016/S0028-3932(02)00149-5
   CAPPS L, 1995, DEV PSYCHOPATHOL, V7, P137
   Chakrabarti B, 2006, SOC NEUROSCI-UK, V1, P364, DOI 10.1080/17470910601041317
   Chakrabarti B, 2009, AUTISM RES, V2, P157, DOI 10.1002/aur.80
   Chakrabarti B, 2006, PROG BRAIN RES, V156, P403, DOI 10.1016/S0079-6123(06)56022-4
   Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
   Darwin C, 1872, EXPRESSION EMOTIONS
   Decety Jean, 2007, Biopsychosoc Med, V1, P22, DOI 10.1186/1751-0759-1-22
   EKMAN P, 1971, J PERS SOC PSYCHOL, V17, P124, DOI 10.1037/h0030377
   FIELD TM, 1982, SCIENCE, V218, P179, DOI 10.1126/science.7123230
   Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x
   GIOIA JV, 1988, INT J NEUROSCI, V43, P149
   Goeleven E, 2008, COGNITION EMOTION, V22, P1094, DOI 10.1080/02699930701626582
   Golan O, 2006, J AUTISM DEV DISORD, V36, P169, DOI 10.1007/s10803-005-0057-y
   Gosling SD, 2004, AM PSYCHOL, V59, P93, DOI 10.1037/0003-066X.59.2.93
   Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636
   Happe F, 2001, J CHILD PSYCHOL PSYC, V42, P299, DOI 10.1111/1469-7610.00723
   Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6
   Holt R, 2011, EMBO MOL MED, V3, P438, DOI 10.1002/emmm.201100157
   Howard MA, 2000, NEUROREPORT, V11, P2931, DOI 10.1097/00001756-200009110-00020
   Isler JR, 2010, CLIN NEUROPHYSIOL, V121, P2035, DOI 10.1016/j.clinph.2010.05.004
   Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
   Lawrence EJ, 2004, PSYCHOL MED, V34, P911, DOI 10.1017/S0033291703001624
   Lee H, 2010, AM J MED GENET B, V153B, P1119, DOI 10.1002/ajmg.b.31103
   LESLIE AM, 1987, PSYCHOL REV, V94, P412, DOI 10.1037/0033-295X.94.4.412
   LESLIE AM, 1988, BRIT J DEV PSYCHOL, V6, P315
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34
   Loveland KA, 1997, DEV PSYCHOPATHOL, V9, P579
   Lundqvist D., 1998, KAROLINSKA DIRECTED
   Mevorach C, 2006, NAT NEUROSCI, V9, P740, DOI 10.1038/nn1709
   Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945
   Montagne B, 2007, PERCEPT MOTOR SKILL, V104, P589, DOI 10.2466/PMS.104.2.589-598
   Palermo MT, 2006, AUTISM, V10, P353, DOI 10.1177/1362361306064431
   Pellicano E., 2011, RES AUTISM SPECT DIS, P219, DOI 10.1017/CBO9780511973918.010
   Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369
   PERNER J, 1989, CHILD DEV, V60, P689, DOI 10.1111/j.1467-8624.1989.tb02749.x
   Phillips W, 1998, BRIT J DEV PSYCHOL, V16, P337
   Raven J. C., 1996, MANUAL RAVENS PROGR
   Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7
   SMALLEY SL, 1990, J AUTISM DEV DISORD, V20, P271, DOI 10.1007/BF02284724
   Smith MJL, 2010, NEUROPSYCHOLOGIA, V48, P2777, DOI 10.1016/j.neuropsychologia.2010.03.008
   Spencer MD, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.18
   Sucksmith E, 2011, NEUROPSYCHOL REV, V21, P360, DOI 10.1007/s11065-011-9183-9
   Sutherland A, 2010, BRAIN, V133, P2089, DOI 10.1093/brain/awq122
   WALDEN TA, 1988, CHILD DEV, V59, P1230, DOI 10.1111/j.1467-8624.1988.tb01492.x
   WalkerAndrews AS, 1997, PSYCHOL BULL, V121, P437, DOI 10.1037/0033-2909.121.3.437
   Wallace S, 2010, AUTISM RES, V3, P345, DOI 10.1002/aur.161
   Wheelwright S, 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-1.PUBMED:20678244
   World Health Organisation, 1993, MENT DIS GLOSS GUID
NR 70
TC 17
Z9 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3932
J9 NEUROPSYCHOLOGIA
JI Neuropsychologia
PD JAN
PY 2013
VL 51
IS 1
BP 98
EP 105
DI 10.1016/j.neuropsychologia.2012.11.013
PG 8
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 083US
UT WOS:000314491300011
PM 23174401
ER

PT J
AU Oksenberg, N
   Stevison, L
   Wall, JD
   Ahituv, N
AF Oksenberg, Nir
   Stevison, Laurie
   Wall, Jeffrey D.
   Ahituv, Nadav
TI Function and Regulation of AUTS2, a Gene Implicated in Autism and Human
   Evolution
SO PLOS GENETICS
LA English
DT Article
ID CONSERVED NONCODING SEQUENCES; COPY NUMBER VARIATION; IN-VIVO;
   TRANSLOCATION BREAKPOINT; SPECTRUM DISORDERS; ZEBRAFISH; GENOME;
   IDENTIFICATION; EXPRESSION; ENHANCERS
AB Nucleotide changes in the AUTS2 locus, some of which affect only noncoding regions, are associated with autism and other neurological disorders, including attention deficit hyperactivity disorder, epilepsy, dyslexia, motor delay, language delay, visual impairment, microcephaly, and alcohol consumption. In addition, AUTS2 contains the most significantly accelerated genomic region differentiating humans from Neanderthals, which is primarily composed of noncoding variants. However, the function and regulation of this gene remain largely unknown. To characterize auts2 function, we knocked it down in zebrafish, leading to a smaller head size, neuronal reduction, and decreased mobility. To characterize AUTS2 regulatory elements, we tested sequences for enhancer activity in zebrafish and mice. We identified 23 functional zebrafish enhancers, 10 of which were active in the brain. Our mouse enhancer assays characterized three mouse brain enhancers that overlap an ASD-associated deletion and four mouse enhancers that reside in regions implicated in human evolution, two of which are active in the brain. Combined, our results show that AUTS2 is important for neurodevelopment and expose candidate enhancer sequences in which nucleotide variation could lead to neurological disease and human-specific traits.
C1 [Oksenberg, Nir; Ahituv, Nadav] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA.
   [Oksenberg, Nir; Stevison, Laurie; Wall, Jeffrey D.; Ahituv, Nadav] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA.
   [Wall, Jeffrey D.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
RP Oksenberg, N (reprint author), Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA.
EM nadav.ahituv@ucsf.edu
FU Simons Foundation (SFARI) [256769]; NHGRI [R01HG005058, R01 HG005226,
   R01HG006768]; NICHD [R01HD059862]; NINDS [R01NS079231]; NIGMS [GM61390];
   NIDDK [R01DK090382]; Genentech Predoctoral fellowship; Dennis
   Weatherstone Pre-doctoral Fellowship from Autism Speaks; NICHD
FX This research was supported by a grant from the Simons Foundation (SFARI
   #256769 to NA), NHGRI grant numbers R01HG005058 (NA) and R01 HG005226
   (LS and JDW), NICHD grant number R01HD059862, and NINDS grant number
   R01NS079231. NA is also supported by NIGMS award number GM61390, NHGRI
   award number R01HG006768, and NIDDK award number R01DK090382. NO was
   supported in part by a Genentech Predoctoral fellowship and is supported
   in part by the Dennis Weatherstone Pre-doctoral Fellowship from Autism
   Speaks. The content is solely the responsibility of the authors and does
   not necessarily represent the official views of the Simons Foundation,
   Autism Speaks, NIH, NICHD, NHGRI, NINDS, NIDDK, or NIGMS. The monoclonal
   antibody znp-1 developed by B. Trevarrow was obtained from the
   Developmental Studies Hybridoma Bank developed under the auspices of the
   NICHD and maintained by The University of Iowa, Department of Biology,
   Iowa City, Iowa, United States of America. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Alenzi FQB, 2004, BRIT J BIOMED SCI, V61, P99
   Baio J, 2012, MMWR SURVEILLANCE SU, P61
   Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017
   Bedogni F, 2010, P NATL ACAD SCI USA, V107, P13129, DOI 10.1073/pnas.1002285107
   Bedogni F, 2010, GENE EXPR PATTERNS, V10, P9, DOI 10.1016/j.gep.2009.11.005
   Ben-David E, 2011, HUM MOL GENET, V20, P3632, DOI 10.1093/hmg/ddr283
   Elia J, 2010, MOL PSYCHIATR, V15, P637, DOI 10.1038/mp.2009.57
   Evan G, 1998, SCIENCE, V281, P1317, DOI 10.1126/science.281.5381.1317
   Fatemi SH, 2005, BIOL PSYCHIAT, V57, P777, DOI 10.1016/j.biopsych.2004.12.018
   Fisher S, 2006, SCIENCE, V312, P276, DOI 10.1126/science.1124070
   Flanagan-Steet H, 2005, DEVELOPMENT, V132, P4471, DOI 10.1242/dev.02044
   Fullwood MJ, 2010, NATURE, V462, P58, DOI [10.1038/nature08497.An, DOI 10.1038/NATURE08497.AN]
   Girirajan S, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002334
   Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953
   Gordon LR, 2012, DEVELOPMENT, V139, P1023, DOI 10.1242/dev.071555
   Green RE, 2010, SCIENCE, V328, P710, DOI 10.1126/science.1188021
   Hevner RF, 2001, NEURON, V29, P353, DOI 10.1016/S0896-6273(01)00211-2
   HOLDER N, 1991, DEVELOPMENT, V113, P1159
   Huang XL, 2010, AM J MED GENET A, V152A, P2112, DOI 10.1002/ajmg.a.33497
   Kalscheuer VM, 2007, HUM GENET, V121, P501, DOI 10.1007/s00439-006-0284-0
   Kawakami K, 2005, DEV DYNAM, V234, P244, DOI 10.1002/dvdy.20516
   KOTHARY R, 1988, NATURE, V335, P435, DOI 10.1038/335435a0
   Li Q, 2010, DEV BIOL, V337, P484, DOI 10.1016/j.ydbio.2009.10.019
   Lieberman-Aiden E, 2009, SCIENCE, V326, P289, DOI 10.1126/science.1181369
   Luciano M, 2012, BIOL PSYCHOL, V86, P193, DOI [10.1016/j.biopsycho.2010.11.008.Whole, DOI 10.1016/J.BIOPSYCHO.2010.11.008.WHOLE]
   McGaughey DM, 2008, GENOME RES, V18, P252, DOI 10.1101/gr.6929408
   Mefford HC, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1000962
   Nagamani SCS, 2012, EUR J HUM GENET, P1
   Nagy A., 2003, MANIPULATING MOUSE E, V3rd
   Nasevicius A, 2000, NAT GENET, V26, P216, DOI 10.1038/79951
   Navratilova P, 2009, DEV BIOL, V327, P526, DOI 10.1016/j.ydbio.2008.10.044
   Nusslein-Volhard C. A. R., 2002, ZEBRAFISH
   Pardo CA, 2007, BRAIN PATHOL, V17, P434, DOI 10.1111/j.1750-3639.2007.00102.x
   Park HC, 2000, DEV BIOL, V227, P279, DOI 10.1006/dbio.2000.9898
   Pennacchio LA, 2006, NATURE, V444, P499, DOI 10.1038/nature05295
   Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146
   Pollard KS, 2006, PLOS GENET, V2, P1599, DOI 10.1371/journal.pgen.0020168
   Poot M, 2011, CYTOGENET GENOME RES, V135, P228, DOI 10.1159/000334064
   Prabhakar S, 2006, SCIENCE, V314, P786, DOI 10.1126/science.1130738
   Pruitt KD, 2005, NUCLEIC ACIDS RES, V33, pD501, DOI 10.1093/nar/gki025
   Risch N, 1999, AM J HUM GENET, V65, P931
   Schumann G, 2011, P NATL ACAD SCI USA, V108, P7119, DOI 10.1073/pnas.1017288108
   Sultana R, 2002, GENOMICS, V80, P129, DOI 10.1006/geno.2002.6810
   Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028
   Thisse B, 2004, METHOD CELL BIOL, V77, P505
   Tropepe V, 2003, GENES BRAIN BEHAV, V2, P268, DOI 10.1046/j.1601-183X.2003.00038.x
   Visel A, 2009, NATURE, V457, P854, DOI 10.1038/nature07730
   Visel A, 2007, NUCLEIC ACIDS RES, V35, pD88, DOI 10.1093/nar/gkl822
   Visel A, 2004, NUCLEIC ACIDS RES, V32, pD552, DOI 10.1093/nar/gkh029
   Westerfield M., 2007, ZEBRAFISH BOOK GUIDE
   White RM, 2008, CELL STEM CELL, V2, P183, DOI 10.1016/j.stem.2007.11.002
   Zhang YE, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001179
NR 52
TC 20
Z9 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD JAN
PY 2013
VL 9
IS 1
AR e1003221
DI 10.1371/journal.pgen.1003221
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 085YZ
UT WOS:000314651500062
PM 23349641
ER

PT J
AU Baganz, NL
   Blakely, RD
AF Baganz, Nicole L.
   Blakely, Randy D.
TI A Dialogue between the Immune System and Brain, Spoken in the Language
   of Serotonin
SO ACS CHEMICAL NEUROSCIENCE
LA English
DT Review
DE Serotonin; serotonin transporter; immune system; P38 MAPK; interleukin-1
   beta; depression
ID CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; T-LYMPHOCYTE FUNCTION;
   NATURAL-KILLER-CELLS; FUNCTIONAL ANATOMICAL ANALYSIS;
   OBSESSIVE-COMPULSIVE DISORDER; TRANSPORTER GENE POLYMORPHISM;
   PERIPHERAL-BLOOD LYMPHOCYTES; ACTIVATED PROTEIN-KINASE; MAJOR DEPRESSION
AB Neuropsychiatric disorders have long been linked to both immune system activation and alterations in serotonin (5-HT) signaling. In the CNS, the contributions of 5-HT modulate a broad range of targets, most notably, hypothalamic, limbic and cortical circuits linked to the control of mood and mood disorders. In the periphery, many are aware of the production and actions of 5-HT in the gut but are unaware that the molecule and its receptors are also present in the immune system where evidence suggests they contribute to the both innate and adaptive responses. In addition, there is clear evidence that the immune system communicates to the brain via both humoral and neuronal mechanisms, and that CNS 5-HT neurons are a direct or indirect target for these actions. Following a brief primer on the immune system, we describe our current understanding of the synthesis, release, and actions of 5-HT in modulating immune function, including the expression of 5-HT biosynthetic enzymes, receptors, and transporters that are typically studied with respect to the roles in the CNS. We then orient our presentation to recent findings that pro-inflammatory cytokines can modulate CNS 5-HT signaling, leading to a conceptualization that among the many roles of 5-HT in the body is an integrated physiological and behavioral response to inflammatory events and pathogens. From this perspective, altered 5-HT/immune conversations are likely to contribute to risk for neurobehavioral disorders historically linked to compromised 5-HT function or ameliorated by 5-HT targeted medications, including depression and anxiety disorders, obsessive-compulsive disorder (OCD), and autism. Our review raises the question as to whether genetic variation impacting 5-HT signaling genes may contribute to maladaptive behavior as much through perturbed immune system modulation as through altered brain mechanisms. Conversely, targeting the immune system for therapeutic development may provide an important opportunity to treat mental illness.
C1 [Baganz, Nicole L.; Blakely, Randy D.] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA.
   [Blakely, Randy D.] Vanderbilt Univ, Med Ctr, Dept Psychiat, Nashville, TN 37232 USA.
RP Baganz, NL (reprint author), Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA.
FU  [MH094527];  [MH078668];  [N5007491]
FX Funding MH094527 and MH078668 (to R.D.B.) and N5007491 (to N.L.B.)
   supported our studies.
CR Ahern GP, 2011, CURR OPIN PHARMACOL, V11, P29, DOI 10.1016/j.coph.2011.02.004
   Amenta F, 2001, J NEUROIMMUNOL, V117, P133, DOI 10.1016/S0165-5728(01)00317-4
   Ansah TA, 2003, J PHARMACOL EXP THER, V305, P956, DOI 10.1124/jpet.102.047134
   Ansorge MS, 2004, SCIENCE, V306, P879, DOI 10.1126/science.1101678
   Anthony IC, 2003, BRAIN, V126, P1058, DOI 10.1093/brain/awg118
   AUNE TM, 1994, J IMMUNOL, V153, P489
   AUNE TM, 1990, J IMMUNOL, V145, P1826
   Babcock TA, 2000, CYTOKINE, V12, P588, DOI 10.1006/cyto.1999.0661
   Baganz N. L., 2012, SOC NEUROSCIENCE
   Bang SJ, 2012, EUR J NEUROSCI, V35, P85, DOI 10.1111/j.1460-9568.2011.07936.x
   Banks WA, 2005, CURR PHARM DESIGN, V11, P973, DOI 10.2174/1381612053381684
   Banks WA, 1995, NEUROIMMUNOMODULAT, V2, P241, DOI 10.1159/000097202
   BANKS WA, 1993, NEUROSCI LETT, V163, P41, DOI 10.1016/0304-3940(93)90224-9
   Bardin L, 2011, BEHAV PHARMACOL, V22, P390, DOI 10.1097/FBP.0b013e328349aae4
   Basterzi AD, 2005, HUM PSYCHOPHARM CLIN, V20, P473, DOI 10.1002/hup.717
   Baune BT, 2010, BIOL PSYCHIAT, V67, P543, DOI 10.1016/j.biopsych.2009.11.004
   Bischoff SC, 2009, AM J PHYSIOL-GASTR L, V296, pG685, DOI 10.1152/ajpgi.90685.2008
   Blakely RD, 1998, BIOL PSYCHIAT, V44, P169, DOI 10.1016/S0006-3223(98)00124-3
   BLAKELY RD, 1991, NATURE, V354, P66, DOI 10.1038/354066a0
   BLATTEIS CM, 1990, YALE J BIOL MED, V63, P133
   BLUNDELL JE, 1984, NEUROPHARMACOLOGY, V23, P1537, DOI 10.1016/0028-3908(84)90098-4
   Boehme SA, 2004, J IMMUNOL, V173, P3599
   Bonnin A, 2011, NEUROSCIENCE, V197, P1, DOI 10.1016/j.neuroscience.2011.10.005
   Brambilla D, 2007, EUR J NEUROSCI, V26, P1862, DOI 10.1111/j.1460-9568.2007.05796.x
   Bruchas MR, 2011, NEURON, V71, P498, DOI 10.1016/j.neuron.2011.06.011
   BULLOCH K, 1984, J COMP NEUROL, V228, P57, DOI 10.1002/cne.902280107
   Buttarelli FR, 2011, CURR NEUROPHARMACOL, V9, P278, DOI 10.2174/157015911795596612
   Canli T, 2007, NAT NEUROSCI, V10, P1103, DOI 10.1038/nn1964
   Capuron L, 1999, NEW ENGL J MED, V340, P1370, DOI 10.1056/NEJM199904293401716
   Capuron L, 2000, J CLIN ONCOL, V18, P2143
   Carneiro AMD, 2009, P NATL ACAD SCI USA, V106, P2047, DOI 10.1073/pnas.0809449106
   Carvalho LSC, 2008, CLIN EXP IMMUNOL, V154, P346, DOI 10.1111/j.1365-2249.2008.03787.x
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Cerri AP, 2010, INT J GERIATR PSYCH, V25, P219, DOI 10.1002/gps.2323
   Cerri AP, 2009, ARCH GERONTOL GERIAT, V49, P29, DOI 10.1016/j.archger.2009.09.009
   Chang J. C, 2012, J NEUROSCI, P8919
   COHEN RA, 1985, J CLIN INVEST, V75, P286, DOI 10.1172/JCI111687
   COHEN RA, 1987, CIRC RES, V61, P829
   Cook EH, 1997, MOL PSYCHIATR, V2, P247
   Crews FT, 2006, ALCOHOL CLIN EXP RES, V30, P720, DOI 10.1111/j.1530-0277.2006.00084.x
   Crona Daniel, 2009, BMC Pulm Med, V9, P19, DOI 10.1186/1471-2466-9-19
   Csaba G, 2006, CELL BIOL INT, V30, P861, DOI 10.1016/j.cellbi.2006.06.021
   Cutler JA, 2012, J PSYCHOPHARMACOL, V26, P360, DOI 10.1177/0269881111434622
   Dang YH, 2000, FREE RADICAL BIO MED, V28, P615, DOI 10.1016/S0891-5849(99)00272-5
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Dantzer R, 2001, ANN NY ACAD SCI, V933, P222
   Dantzer R, 2011, PSYCHONEUROENDOCRINO, V36, P426, DOI 10.1016/j.psyneuen.2010.09.012
   Daws LC, 2000, J NEUROCHEM, V75, P2113, DOI 10.1046/j.1471-4159.2000.0752113.x
   DINARELLO CA, 1984, REV INFECT DIS, V6, P51
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Ducy P, 2011, CURR OPIN PHARMACOL, V11, P34, DOI 10.1016/j.coph.2011.01.007
   Dumery L, 2001, PATHOL BIOL, V49, P72, DOI 10.1016/S0369-8114(00)00009-2
   DUNN AJ, 1991, J NEUROCHEM, V57, P1615, DOI 10.1111/j.1471-4159.1991.tb06359.x
   DUNN AJ, 1988, LIFE SCI, V43, P429, DOI 10.1016/0024-3205(88)90522-X
   DUNN AJ, 1992, J PHARMACOL EXP THER, V261, P964
   Dunn MJ, 2006, PSYCHOPHARMACOLOGY, V188, P183, DOI 10.1007/s00213-006-0488-y
   Eisenberger NI, 2010, BIOL PSYCHIAT, V68, P748, DOI 10.1016/j.biopsych.2010.06.010
   Eisenberger NI, 2010, BRAIN BEHAV IMMUN, V24, P558, DOI 10.1016/j.bbi.2009.12.009
   Ek M, 1998, J NEUROSCI, V18, P9471
   ERICSSON A, 1994, J NEUROSCI, V14, P897
   Evans DL, 2008, BIOL PSYCHIAT, V63, P899, DOI 10.1016/j.biopsych.2007.08.012
   Feinn R, 2005, AM J MED GENET B, V133B, P79, DOI 10.1002/ajmg.b.30132
   FINOCCHIARO LME, 1988, J INTERFERON RES, V8, P705, DOI 10.1089/jir.1988.8.705
   Frank MG, 1999, NEUROPSYCHOBIOLOGY, V39, P18, DOI 10.1159/000026555
   Freire-Garabal M, 2003, BRIT J PHARMACOL, V139, P457, DOI 10.1038/sj.bjp.0705188
   FULLER RW, 1990, ANN NY ACAD SCI, V600, P68, DOI 10.1111/j.1749-6632.1990.tb16873.x
   Galecki P, 2010, NEUROPSYCHOBIOLOGY, V62, P116, DOI 10.1159/000317284
   Gaspar P, 2003, NAT REV NEUROSCI, V4, P1002, DOI 10.1038/nrn1256
   Gershon MD, 2007, GASTROENTEROLOGY, V132, P397, DOI 10.1053/j.gastro.2006.11.002
   GERSHON MD, 1965, SCIENCE, V149, P197, DOI 10.1126/science.149.3680.197
   Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225
   Goehler LE, 1999, J NEUROSCI, V19, P2799
   Goehler LE, 1998, BRAIN RES, V804, P306, DOI 10.1016/S0006-8993(98)00685-4
   Hofstetter Hh, 2009, Int MS J, V16, P12
   Gordon J, 2003, TRENDS IMMUNOL, V24, P438, DOI 10.1016/S1471-4906(03)00176-5
   Guillemin GJ, 2001, J INTERF CYTOK RES, V21, P1097, DOI 10.1089/107999001317205231
   GUTIERREZ EG, 1993, J NEUROIMMUNOL, V47, P169, DOI 10.1016/0165-5728(93)90027-V
   GUTIERREZ EG, 1994, J NEUROIMMUNOL, V55, P153, DOI 10.1016/0165-5728(94)90005-1
   Hannestad J, 2011, NEUROPSYCHOPHARMACOL, V36, P2452, DOI 10.1038/npp.2011.132
   HELLSTRAND K, 1990, CELL IMMUNOL, V127, P199, DOI 10.1016/0008-8749(90)90125-B
   HELLSTRAND K, 1993, J INTERFERON RES, V13, P33, DOI 10.1089/jir.1993.13.33
   HELLSTRAND K, 1993, SCAND J IMMUNOL, V37, P7, DOI 10.1111/j.1365-3083.1993.tb01658.x
   HELLSTRAND K, 1987, J IMMUNOL, V139, P869
   Herkenham M, 1998, J COMP NEUROL, V400, P175, DOI 10.1002/(SICI)1096-9861(19981019)400:2<175::AID-CNE2>3.0.CO;2-6
   Hernandez ME, 2010, EUR NEUROPSYCHOPHARM, V20, P88, DOI 10.1016/j.euroneuro.2009.11.005
   HICKEY WF, 1991, J NEUROSCI RES, V28, P254, DOI 10.1002/jnr.490280213
   HOFFMAN BJ, 1991, SCIENCE, V254, P579, DOI 10.1126/science.1948036
   HOLZWARTH MA, 1985, NEUROENDOCRINOLOGY, V41, P230, DOI 10.1159/000124182
   Horikawa H, 2010, PROG NEURO-PSYCHOPH, V34, P1306, DOI 10.1016/j.pnpbp.2010.07.015
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Hsiao EY, 2012, P NATL ACAD SCI USA, V109, P12776, DOI 10.1073/pnas.1202556109
   Hwang JP, 2009, NEUROMOL MED, V11, P322, DOI 10.1007/s12017-009-8078-x
   Idzko M, 2004, J IMMUNOL, V172, P6011
   Irwin MR, 2007, BRAIN BEHAV IMMUN, V21, P374, DOI 10.1016/j.bbi.2007.01.010
   JACKSON BP, 1995, BRAIN RES, V674, P163, DOI 10.1016/0006-8993(95)00019-M
   JACKSON JC, 1988, LIFE SCI, V42, P1641, DOI 10.1016/0024-3205(88)90443-2
   KABIERSCH A, 1988, Brain Behavior and Immunity, V2, P267, DOI 10.1016/0889-1591(88)90028-1
   Kacimi R, 2011, J INFLAMM-LOND, V8, DOI 10.1186/1476-9255-8-7
   Karsenty G, 2011, ANNU REV MED, V62, P323, DOI 10.1146/annurev-med-090710-133426
   Katoh N, 2006, CLIN EXP IMMUNOL, V146, P354, DOI 10.1111/j.1365-2249.2006.03197.x
   KAWASAKI H, 1984, J PHARMACOL EXP THER, V229, P816
   Kelly RW, 1997, HUM REPROD, V12, P677, DOI 10.1093/humrep/12.4.677
   KENT S, 1992, TRENDS PHARMACOL SCI, V13, P24, DOI 10.1016/0165-6147(92)90012-U
   Kim DY, 2000, AM J GASTROENTEROL, V95, P2698, DOI 10.1016/S0002-9270(00)01970-5
   Kim H, 2012, J CLIN INVEST, V122, P2940, DOI 10.1172/JCI61884
   KONIG B, 1992, INFECT IMMUN, V60, P3150
   Konsman JP, 2000, EUR J NEUROSCI, V12, P4434, DOI 10.1046/j.0953-816X.2000.01319.x
   Kushnir-Sukhov NM, 2006, J IMMUNOL, V177, P6422
   Kushnir-Sukhov NM, 2007, J ALLERGY CLIN IMMUN, V119, P498, DOI 10.1016/j.jaci.2006.09.003
   KUT JL, 1992, IMMUNOPHARM IMMUNOT, V14, P783, DOI 10.3109/08923979209009235
   Lasky-Su JA, 2005, AM J MED GENET B, V133B, P110, DOI 10.1016/j.ajmg.b.30104
   Leon-Ponte M, 2007, BLOOD, V109, P3139, DOI 10.1182/blood-2006-10-052787
   Lesch KP, 1996, SCIENCE, V274, P1527, DOI 10.1126/science.274.5292.1527
   Lesurtel M, 2006, SCIENCE, V312, P104, DOI 10.1126/science.1123842
   Lesurtel M, 2008, CELL MOL LIFE SCI, V65, P940, DOI 10.1007/s00018-007-7377-3
   Li N, 2011, AM J PATHOL, V178, P662, DOI 10.1016/j.ajpath.2010.10.028
   Li N, 1997, BLOOD COAGUL FIBRIN, V8, P517, DOI 10.1097/00001721-199711000-00006
   Lima L, 2005, NEUROIMMUNOMODULAT, V12, P299, DOI 10.1159/000087108
   Lima L, 2002, CELL MOL NEUROBIOL, V22, P797, DOI 10.1023/A:1021869310702
   Lin PY, 2007, PROG NEURO-PSYCHOPH, V31, P683, DOI 10.1016/j.pnpbp.2006.12.024
   Lindler K. M., 2012, SOC NEUROSCIENCE
   Linthorst ACE, 1996, NEUROSCIENCE, V72, P989, DOI 10.1016/0306-4522(95)00604-4
   LOPPNOW H, 1990, INFECT IMMUN, V58, P3743
   Lotrich FE, 2004, PSYCHIAT GENET, V14, P121, DOI 10.1097/00041444-200409000-00001
   Lucki I, 1998, BIOL PSYCHIAT, V44, P151, DOI 10.1016/S0006-3223(98)00139-5
   Ma XLC, 2000, BRAIN RES, V861, P135, DOI 10.1016/S0006-8993(00)02023-0
   Maes M, 1997, EUR ARCH PSY CLIN N, V247, P154
   Maes M, 2001, HUM PSYCHOPHARM CLIN, V16, P95, DOI 10.1002/hup.191
   MAGNI F, 1987, BRAIN RES, V424, P379, DOI 10.1016/0006-8993(87)91483-1
   Marazziti D, 2008, NEUROCHEM RES, V33, P1011, DOI 10.1007/s11064-007-9541-4
   Marazziti D, 2010, MINI-REV MED CHEM, V10, P32
   Mark KS, 1999, LIFE SCI, V64, P1941, DOI 10.1016/S0024-3205(99)00139-3
   Martins LCA, 2012, J NEUROIMMUNOL, V251, P73, DOI 10.1016/j.jneuroim.2012.06.003
   Masson J., 2009, ENCY NEUROSCI, P921
   Matsumura Y, 2006, J IMMUNOL, V177, P4810
   Matsunaga M, 2010, NEUROSCI LETT, V468, P211, DOI 10.1016/j.neulet.2009.10.093
   McDougle CJ, 1998, MOL PSYCHIATR, V3, P270, DOI 10.1038/sj.mp.4000391
   McLay RN, 2000, NEUROIMMUNOMODULAT, V8, P148, DOI 10.1159/000054275
   Merali Z, 1997, BRAIN RES, V761, P225, DOI 10.1016/S0006-8993(97)00312-0
   Meredith EJ, 2005, FASEB J, V19, P1187, DOI 10.1096/fj.04-3477fje
   Meredith EJ, 2005, IMMUNOLOGY, V115, P289, DOI 10.1111/j.1365-2567.2005.02166.x
   MOHANKUMAR PS, 1993, BRAIN RES BULL, V31, P745, DOI 10.1016/0361-9230(93)90151-Z
   Monti JM, 2011, SLEEP MED REV, V15, P269, DOI 10.1016/j.smrv.2010.11.003
   Moon HY, 2012, P NATL ACAD SCI USA, V109, P13094, DOI 10.1073/pnas.1205535109
   MOORE RY, 1978, J COMP NEUROL, V180, P417, DOI 10.1002/cne.901800302
   Morikawa O, 1998, EUR J PHARMACOL, V349, P317, DOI 10.1016/S0014-2999(98)00187-3
   Mossner R, 1998, BRAIN BEHAV IMMUN, V12, P249, DOI 10.1006/brbi.1998.0532
   Mossner R, 2001, LIFE SCI, V68, P873, DOI 10.1016/S0024-3205(00)00992-9
   Mossner R, 1998, NEUROCHEM INT, V33, P251, DOI 10.1016/S0197-0186(98)00026-6
   Müller Tobias, 2009, PLoS One, V4, pe6453, DOI 10.1371/journal.pone.0006453
   Murphy DL, 2008, NAT REV NEUROSCI, V9, P85, DOI 10.1038/nrn2284
   NIIJIMA A, 1995, J AUTONOM NERV SYST, V54, P137, DOI 10.1016/0165-1838(95)00003-G
   O'Brien SM, 2007, J PSYCHIAT RES, V41, P326, DOI 10.1016/j.jpsychires.2006.05.013
   O'Connell PJ, 2006, BLOOD, V107, P1010, DOI 10.1182/blood-2005-07-2903
   Olofsson PS, 2012, IMMUNOL REV, V248, P188, DOI 10.1111/j.1600-065X.2012.01138.x
   Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007
   Parkin J, 2001, LANCET, V357, P1777, DOI 10.1016/S0140-6736(00)04904-7
   Passamonti L, 2012, BIOL PSYCHIAT, V71, P36, DOI 10.1016/j.biopsych.2011.07.033
   Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001
   Persidsky Y, 1997, J IMMUNOL, V158, P3499
   PFEIFFER JR, 1985, J CELL BIOL, V101, P2145, DOI 10.1083/jcb.101.6.2145
   POSPIESZNY N, 1979, ANAT ANZEIGER, V146, P47
   Pousset F, 1996, MOL BRAIN RES, V38, P54, DOI 10.1016/0169-328X(95)00324-L
   Prasad H. C., 2012, BIOL PSYCH C PHIL PA
   Prasad HC, 2005, P NATL ACAD SCI USA, V102, P11545, DOI 10.1073/pnas.0501432102
   PRYCE G, 1994, J IMMUNOL METHODS, V167, P55, DOI 10.1016/0022-1759(94)90074-4
   Qian Y, 1997, J NEUROSCI, V17, P45
   Qin LY, 2008, J NEUROINFLAMM, V5, DOI 10.1186/1742-2094-5-10
   Quan N, 1997, P NATL ACAD SCI USA, V94, P10985, DOI 10.1073/pnas.94.20.10985
   Ramamoorthy S, 1998, METHOD ENZYMOL, V296, P347
   RAMAMOORTHY S, 1995, BIOCHEM BIOPH RES CO, V216, P560, DOI 10.1006/bbrc.1995.2659
   Ramamoorthy S, 1999, SCIENCE, V285, P763, DOI 10.1126/science.285.5428.763
   Ramamoorthy S, 1998, J BIOL CHEM, V273, P2458, DOI 10.1074/jbc.273.4.2458
   RAMAMOORTHY S, 1993, P NATL ACAD SCI USA, V90, P2542, DOI 10.1073/pnas.90.6.2542
   Ramamoorthy S., 1998, SOC NEUR C LOS ANG C
   Ramamoorthy S, 2007, J BIOL CHEM, V282, P11639, DOI 10.1074/jbc.M611353200
   Ransohoff RM, 2012, J CLIN INVEST, V122, P1164, DOI 10.1172/JCI58644
   RAUB TJ, 1992, EXP CELL RES, V199, P330, DOI 10.1016/0014-4827(92)90442-B
   REDDY NP, 1986, CRIT REV BIOMED ENG, V14, P45
   Rodriguez MJ, 2001, CELL TISSUE RES, V304, P215, DOI 10.1007/s004410100361
   Romeo HE, 2003, J NEUROIMMUNOL, V136, P104, DOI 10.1016/S0165-5728(0300033-X
   Roosevelt RW, 2006, BRAIN RES, V1119, P124, DOI 10.1016/j.brainres.2006.08.048
   Rosas-Ballina M, 2008, P NATL ACAD SCI USA, V105, P11008, DOI 10.1073/pnas.0803237105
   Rudd ML, 2005, J NEUROIMMUNOL, V159, P113, DOI 10.1016/j.jneuroim.2004.10.013
   Sacre S, 2010, ARTHRITIS RHEUM-US, V62, P683, DOI 10.1002/art.27304
   SAITO A, 1987, CIRC RES, V60, P220
   Sakash JB, 2002, INFECT IMMUN, V70, P3959, DOI 10.1128/IAI.70.7.3959-3961.2002
   Schiepers OJG, 2005, PROG NEURO-PSYCHOPH, V29, P201, DOI 10.1016/j.pnpbp.2004.11.003
   Schinka JA, 2004, MOL PSYCHIATR, V9, P197, DOI 10.1038/sj.mp.4001405
   Schneider E, 2011, J ALLERGY CLIN IMMUN, V128, P864, DOI 10.1016/j.jaci.2011.04.043
   Schneider E., 2011, J ALLERGY CLIN IMMUN, V128, pe862
   Schroeter S, 1997, MOL CELL NEUROSCI, V9, P170, DOI 10.1006/mcne.1997.0619
   Serafeim A, 2002, BLOOD, V99, P2545, DOI 10.1182/blood.V99.7.2545
   Shapiro-Shelef M, 2005, NAT REV IMMUNOL, V5, P230, DOI 10.1038/nri1572
   SHINTANI F, 1993, J NEUROSCI, V13, P3574
   Singh YS, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.2
   Singh YS, 2010, ACS CHEM NEUROSCI, V1, P49, DOI 10.1021/cn900012y
   SMITH RS, 1991, MED HYPOTHESES, V35, P298, DOI 10.1016/0306-9877(91)90272-Z
   STAMFORD JA, 1990, BRAIN RES, V515, P173, DOI 10.1016/0006-8993(90)90593-Z
   Steiner JA, 2008, TRAFFIC, V9, P1393, DOI 10.1111/j.1600-0854.2008.00757.x
   Su SY, 2009, CIRC-CARDIOVASC GENE, V2, P614, DOI 10.1161/CIRCGENETICS.109.870386
   Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648
   Svenningsson P, 2006, SCIENCE, V311, P77, DOI 10.1126/science.1117571
   Tadić André, 2008, Neuropsychiatr Dis Treat, V4, P269
   TAMIR H, 1982, J CELL BIOL, V93, P638, DOI 10.1083/jcb.93.3.638
   THOA NB, 1969, J PHARMACOL EXP THER, V169, P68
   Thompson BJ, 2011, P NATL ACAD SCI USA, V108, P3785, DOI 10.1073/pnas.1011920108
   Tsao CW, 2006, PROG NEURO-PSYCHOPH, V30, P899, DOI 10.1016/j.pnpbp.2006.01.029
   Tynan RJ, 2012, BRAIN BEHAV IMMUN, V26, P469, DOI 10.1016/j.bbi.2011.12.011
   Uher R, 2008, MOL PSYCHIATR, V13, P131, DOI 10.1038/sj.mp.4002067
   Uher R, 2010, AM J PSYCHIAT, V167, P555, DOI 10.1176/appi.ajp.2009.09070932
   van Erp AMM, 2000, J NEUROSCI, V20, P9320
   Veenstra-VanderWeele J, 2012, NEUROPSYCHOPHARMACOL, V37, P196, DOI 10.1038/npp.2011.185
   Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109
   VERBEUREN TJ, 1983, J PHARMACOL EXP THER, V226, P579
   VERHOFSTAD AAJ, 1983, NEUROSCIENCE, V10, P1443, DOI 10.1016/0306-4522(83)90125-2
   Vogelzangs N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.8
   Walther DJ, 2003, CELL, V115, P851, DOI 10.1016/S0092-8674(03)01014-6
   WAN WH, 1994, BRAIN RES BULL, V34, P7, DOI 10.1016/0361-9230(94)90179-1
   Warner-Schmidt JL, 2011, P NATL ACAD SCI USA, V108, P9262, DOI 10.1073/pnas.1104836108
   Warner-Schmidt JL, 2010, BIOL PSYCHIAT, V68, P528, DOI 10.1016/j.biopsych.2010.04.029
   Warner-Schmidt JL, 2009, J NEUROSCI, V29, P1937, DOI 10.1523/JNEUROSCI.5343-08.2009
   WHITE JG, 1970, SCAND J HAEMATOL, V7, P145
   WILCOX BD, 1994, J BIOL CHEM, V269, P29658
   Wong A, 2012, J BIOL CHEM, V287, P36051, DOI 10.1074/jbc.M112.394726
   Wong ML, 2008, MOL PSYCHIATR, V13, P800, DOI 10.1038/mp.2008.59
   Yirmiya R, 2000, ANN NY ACAD SCI, V917, P478
   YOUNG MRI, 1993, IMMUNOLOGY, V80, P395
   YOUNG MRI, 1995, IMMUNOLOGY, V84, P148
   Yu Younger W.-Y., 2003, Neuropsychopharmacology, V28, P1182
   Zhang JJ, 2001, NEUROCHEM INT, V38, P303, DOI 10.1016/S0197-0186(00)00099-1
   Zhu CB, 2010, NEUROPSYCHOPHARMACOL, V35, P2510, DOI 10.1038/npp.2010.116
   Zhu CB, 2006, NEUROPSYCHOPHARMACOL, V31, P2121, DOI 10.1038/sj.npp.1301029
   Zhu CB, 2005, J BIOL CHEM, V280, P15649, DOI 10.1074/jbc.M410858200
   Zhu CB, 2004, EUR J PHARMACOL, V504, P1, DOI 10.1016/j.ejphar.2004.09.023
   Zhu CB, 2004, MOL PHARMACOL, V65, P1462, DOI 10.1124/mol.65.6.1462
   ZHU J, 1995, IMMUNOPHARM IMMUNOT, V17, P109, DOI 10.3109/08923979509052724
NR 237
TC 23
Z9 23
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7193
J9 ACS CHEM NEUROSCI
JI ACS Chem. Neurosci.
PD JAN
PY 2013
VL 4
IS 1
BP 48
EP 63
DI 10.1021/cn300186b
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Neurosciences
   & Neurology
GA 075XN
UT WOS:000313920600011
PM 23336044
ER

PT J
AU Coolidge, FL
   Marle, PD
   Rhoades, CS
   Monaghan, P
   Segal, DL
AF Coolidge, Frederick L.
   Marle, Peter D.
   Rhoades, Camille S.
   Monaghan, Patricia
   Segal, Daniel L.
TI Psychometric Properties of a New Measure to Assess Autism Spectrum
   Disorder in DSM-5
SO AMERICAN JOURNAL OF ORTHOPSYCHIATRY
LA English
DT Article
DE children; autism; autism spectrum disorder; high-functioning autism;
   pervasive developmental disorder; Asperger's disorder; schizoid
   personality disorder; attention deficit hyperactivity disorder
ID DEFICIT HYPERACTIVITY DISORDER; EXECUTIVE FUNCTION DEFICITS;
   PERSONALITY-DISORDERS; CHILDREN; HERITABILITY; SAMPLE
AB This article presents preliminary psychometric properties of a new 45-item scale, the Coolidge Autistic Symptoms Survey (CASS), designed to differentiate between children within the autism spectrum (including Asperger's Disorder) and purportedly normal children, in anticipation of DSM-5 changes, in which a single diagnostic category is proposed: autism spectrum disorder. The final sample (N = 72) consisted of 19 children diagnosed with Asperger's Disorder, 19 children who were considered loners by their parents (without an autism diagnosis), and 34 purportedly normal children. The CASS and the 200-item, DSM-IV-TR aligned, Coolidge Personality and Neuropsychological Inventory were completed by a parent. The CASS had excellent internal scale reliability (a= .97) and testretest (r = .91) reliability. ANOVA revealed the CASS was able to discriminate significantly among the 3 groups of children. Further research with the CASS appears warranted.
C1 [Coolidge, Frederick L.] Univ Colorado, Dept Psychol, Colorado Springs, CO 80918 USA.
   [Monaghan, Patricia] Nova SE Univ, Ft Lauderdale, FL 33314 USA.
RP Coolidge, FL (reprint author), Univ Colorado, Dept Psychol, 1420 Austin Bluffs Pkwy, Colorado Springs, CO 80918 USA.
EM fcoolidg@uccs.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Psychiatric Association, 2011, DSM 5 DEV
   Coolidge F. L., 2004, BEHAV GENET, V34, P73
   Coolidge F. L., 2010, BEHAV GENET, V34, P73
   Coolidge F. L., 2007, J CLIN NEUROPHYSIOL, V24, P1
   Coolidge F. L., 2000, CPNI MANUAL
   Coolidge FL, 2002, BEHAV MODIF, V26, P550, DOI 10.1177/0145445502026004007
   Coolidge FL, 2000, J RES PERS, V34, P554, DOI 10.1006/jrpe.2000.2298
   Coolidge FL, 2001, J PERS DISORD, V15, P33, DOI 10.1521/pedi.15.1.33.18645
   Coolidge FL, 2002, BEHAV GENET, V32, P251, DOI 10.1023/A:1019724712983
   Coolidge FL, 2000, DEV NEUROPSYCHOL, V17, P273, DOI 10.1207/S15326942DN1703_1
   Coolidge FL, 2004, PERS INDIV DIFFER, V36, P1559, DOI 10.1016/j.paid.2003.06.005
   CRONBACH LJ, 1951, PSYCHOMETRIKA, V16, P297
   Edelson M. G., 2006, FOCUS AUTISM OTHER D, V21, P66, DOI DOI 10.1177/10883576060210020301
   Grant BF, 2004, J CLIN PSYCHIAT, V65, P948
   Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737
   OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x
   Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013
   Thede LL, 2007, J AUTISM DEV DISORD, V37, P847, DOI 10.1007/s10803-006-0212-0
   Tincani M., 2004, FOCUS AUTISM OTHER D, V19, P152, DOI DOI 10.1177/10883576040190030301
   Wolff S., 1995, LONERS LIFE PATH UNU
NR 21
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-9432
J9 AM J ORTHOPSYCHIAT
JI Am. J. Orthopsychiatr.
PD JAN
PY 2013
VL 83
IS 1
BP 126
EP 130
DI 10.1111/ajop.12012
PG 5
WC Psychiatry; Social Work
SC Psychiatry; Social Work
GA 074MC
UT WOS:000313815600014
PM 23330630
ER

PT J
AU Tanabe, T
   Kashiwagi, M
   Shimakawa, S
   Fukui, M
   Kadobayashi, K
   Azumakawa, K
   Tamai, H
   Wakamiya, E
AF Tanabe, Takuya
   Kashiwagi, Mitsuru
   Shimakawa, Shuichi
   Fukui, Miho
   Kadobayashi, Kazuko
   Azumakawa, Kohji
   Tamai, Hiroshi
   Wakamiya, Eiji
TI Behavioral assessment of Japanese children with epilepsy using SDQ
   (strengths and difficulties questionnaire)
SO BRAIN & DEVELOPMENT
LA English
DT Article
DE SDQ (strengths and difficulties questionnaire); Epilepsy; Behavior;
   Psychiatric comorbidity; AD/HD (attention-deficit/hyperactivity
   disorder); QOL (quality of life)
ID DEFICIT HYPERACTIVITY DISORDER; QUALITY-OF-LIFE; AUTISM SPECTRUM
   DISORDERS; MENTAL-HEALTH PROBLEMS; PEDIATRIC EPILEPSY; POPULATION
   SURVEY; ADOLESCENTS; SEIZURES; SCHOOL; ADHD
AB The aim of this study was to elucidate the availability of the strengths and difficulties questionnaire (SDQ) as a screening tool for identifying behavioral problems in Japanese children with epilepsy. Methods: Eighty-three 4-16 year-old epileptic patients, followed at Tanabe-Kadobayashi Children's Clinic, were studied. Children with severe mental or physical disability were excluded. The Japanese version of the SDQ was used, and scores were compared to the Japanese standard. Results: 'Hyperactivity' was the SDQ category with the most striking differences from normal: a significant numbers of children had scores above the clinically normal range and only a small proportion were within the normal range (p < 0.0001). The rates of epilepsy patients with scores above normal range were also significantly higher for 'peer problems' and 'conduct problems' (p < 0.0001 and p < 0.01). The rates of epilepsy patients with scores within the normal range was significantly lower for 'emotional symptoms' than in normal controls (p < 0.001). On the other hand, the 'pro-social behavior' score did not differ significantly from the Japanese standard. As for clinical factors, patients with symptomatic localization-related epilepsy and focal electroencephalographic abnormalities had significantly higher scores for some SDQ items. Age at epilepsy onset correlated negatively with scores for 'total difficulties' and 'hyperactivity', suggesting early onset to be a risk factor for poor SDQ scores. Conclusions: These findings confirm that higher rates of psychiatric comorbidity in Japanese children with epilepsy may be diagnosed using SDQ in Japanese children with epilepsy. These problems should be addressed in the early phase of epilepsy management in order to preserve health-related quality of life for affected patients. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
C1 [Kashiwagi, Mitsuru] Hirakata City Hosp, Dept Pediat, Hirakata, Osaka, Japan.
   [Shimakawa, Shuichi; Fukui, Miho; Tamai, Hiroshi] Osaka Med Coll, Dept Pediat, Osaka, Japan.
   [Azumakawa, Kohji] Seikeikai Hosp, Dept Pediat, Osaka, Japan.
   [Wakamiya, Eiji] Aino Univ, Dept Nursing, Fac Nursing & Rehabil, Takatsuki, Osaka, Japan.
RP Tanabe, T (reprint author), 1-49-31 Higashiyama, Hirakata, Osaka, Japan.
EM tanakado-neuro.2010@wave.zaq.jp
CR Askalan R, 2003, J CHILD NEUROL, V18, P165, DOI 10.1177/08830738030180030801
   Bennett-Back O, 2011, PEDIATR NEUROL, V44, P187, DOI 10.1016/j.pediatrneurol.2010.10.003
   Curatolo P, 2010, J CHILD NEUROL, V25, P873, DOI 10.1177/0883073810361789
   Davies S, 2003, DEV MED CHILD NEUROL, V45, P292, DOI 10.1017/S0012162203000550
   Hanssen-Bauer K, 2007, EPILEPSY BEHAV, V10, P255, DOI 10.1016/j.yebeh.2006.11.011
   Hesdorffer DC, 2004, ARCH GEN PSYCHIAT, V61, P731, DOI 10.1001/archpsyc.61.7.731
   Izuka C, 2010, BRAIN DEV, V32, P609
   Kubota H, 2010, EPILEPSY BEHAV, V18, P381, DOI 10.1016/j.yebeh.2010.04.045
   Lossius MI, 2006, EPILEPSY BEHAV, V9, P286, DOI 10.1016/j.yebeh.2006.06.018
   Matsuishi T, 2008, BRAIN DEV-JPN, V30, P410, DOI 10.1016/j.braindev.2007.12.003
   Ott D, 2003, EPILEPSIA, V44, P591, DOI 10.1046/j.1528-1157.2003.25002.x
   Saemundsen E, 2007, EPILEPSIA, V48, P1724, DOI 10.1111/j.1528-1167.2007.01150.x
   Sherman EMS, 2007, EPILEPSIA, V48, P1083, DOI 10.1111/j.1528-1167.2007.01028.x
   Turky A, 2008, EPILEPSY BEHAV, V12, P136, DOI 10.1016/j.yebeh.2007.08.003
   Vega C, 2010, EPILEPSY BEHAV, V19, P82, DOI 10.1016/j.yebeh.2010.06.010
   Wannag E, 2010, EPILEPSY BEHAV, V18, P445, DOI 10.1016/j.yebeh.2010.05.013
   Yoo HK, 2009, EPILEPTIC DISORD, V11, P301, DOI 10.1684/epd.2009.0278
NR 17
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0387-7604
J9 BRAIN DEV-JPN
JI Brain Dev.
PD JAN
PY 2013
VL 35
IS 1
BP 81
EP 86
DI 10.1016/j.braindev.2012.03.008
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 079WP
UT WOS:000314203200014
PM 22494963
ER

PT J
AU Seneff, S
   Lauritzen, A
   Davidson, RM
   Lentz-Marino, L
AF Seneff, Stephanie
   Lauritzen, Ann
   Davidson, Robert M.
   Lentz-Marino, Laurie
TI Is Encephalopathy a Mechanism to Renew Sulfate in Autism?
SO ENTROPY
LA English
DT Review
DE encephalitis; autism; nitric oxide; cholesterol sulfate; ammonia;
   aluminum; mercury; lead; glyphosate; seizures; taurine
ID BLOOD-BRAIN-BARRIER; NITRIC-OXIDE SYNTHASE; LONG-TERM POTENTIATION;
   ALUMINUM VACCINE ADJUVANTS; NMDA-RECEPTOR ENCEPHALITIS; RAT
   HIPPOCAMPAL-NEURONS; AMMONIA-LYASE ACTIVITY; LEMLI-OPITZ-SYNDROME;
   LATE-ONSET AUTISM; SPECTRUM DISORDERS
AB This paper makes two claims: (1) autism can be characterized as a chronic low-grade encephalopathy, associated with excess exposure to nitric oxide, ammonia and glutamate in the central nervous system, which leads to hippocampal pathologies and resulting cognitive impairment, and (2), encephalitis is provoked by a systemic deficiency in sulfate, but associated seizures and fever support sulfate restoration. We argue that impaired synthesis of cholesterol sulfate in the skin and red blood cells, catalyzed by sunlight and nitric oxide synthase enzymes, creates a state of colloidal instability in the blood manifested as a low zeta potential and increased interfacial stress. Encephalitis, while life-threatening, can result in partial renewal of sulfate supply, promoting neuronal survival. Research is cited showing how taurine may not only help protect neurons from hypochlorite exposure, but also provide a source for sulfate renewal. Several environmental factors can synergistically promote the encephalopathy of autism, including the herbicide, glyphosate, aluminum, mercury, lead, nutritional deficiencies in thiamine and zinc, and yeast overgrowth due to excess dietary sugar. Given these facts, dietary and lifestyle changes, including increased sulfur ingestion, organic whole foods, increased sun exposure, and avoidance of toxins such as aluminum, mercury, and lead, may help to alleviate symptoms or, in some instances, to prevent autism altogether.
C1 [Seneff, Stephanie] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA.
   [Davidson, Robert M.] PhyNet Inc, Internal Med Grp Practice, Longview, TX 75604 USA.
   [Lentz-Marino, Laurie] Mt Holyoke Coll, Biochem Lab, S Hadley, MA 01075 USA.
RP Seneff, S (reprint author), MIT, Comp Sci & Artificial Intelligence Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
EM Seneff@csail.mit.edu; crzdcmst@sbcglobal.net; patrons99@yahoo.com;
   pcallist@yahoo.com
FU Quanta Computers, Taipei, Taiwan, under the auspices of the Qmulus
   Project
FX This work was funded in part by Quanta Computers, Taipei, Taiwan, under
   the auspices of the Qmulus Project. We would like to thank Anthony
   Samsel for alerting us to a role for glyphosate in disruption of gut
   bacteria. We are indebted to two anonymous reviewers whose thoughtful
   comments led to a much-improved version of the paper.
CR Adams JB, 2011, BMC PEDIATR, V11, DOI 10.1186/1471-2431-11-111
   Aguilar MA, 2000, EXP NEUROL, V161, P704, DOI 10.1006/exnr.1999.7299
   Albrecht J., 1994, BRAIN RES, V660, P228
   Albrecht J, 1998, J NEUROSCI RES, V51, P133, DOI 10.1002/(SICI)1097-4547(19980115)51:2<133::AID-JNR1>3.0.CO;2-E
   Alvarez MN, 2011, J BIOL CHEM, V286, P6627, DOI 10.1074/jbc.M110.167247
   Aneja A, 2008, INT REV PSYCHIATR, V20, P165, DOI 10.1080/09540260801889062
   [Anonymous], 2007, EUR J PEDIAT, V166, P645
   Ashwood P, 2006, J LEUKOCYTE BIOL, V80, P1, DOI 10.1189/jlb.1205707
   Barton ME, 2001, EPILEPSY RES, V47, P217, DOI 10.1016/S0920-1211(01)00302-3
   Beckham J.D., 2009, PRINCIPLES PRACTICE
   Benghezal M, 2006, CELL MICROBIOL, V8, P139, DOI 10.1111/j.1462-5822.2005.00607.x
   Bennetto L, 2004, J NEUROL NEUROSUR PS, V75, pI22, DOI 10.1136/jnnp.2003.034256
   BINDRA GS, 1986, NUTR RES, V6, P475, DOI 10.1016/S0271-5317(86)80101-4
   Bjorck I., 1994, AM J CLIN NUTR, V59, p699S
   Blaylock R. L., 2012, CURR INORG CHEM, V2, P46
   Blaylock RL, 2009, CURR MED CHEM, V16, P157
   Boltor PF, 2011, BRIT J PSYCHIAT, V198, P289, DOI 10.1192/bjp.bp.109.076877
   Bondy SC, 2010, NEUROTOXICOLOGY, V31, P575, DOI 10.1016/j.neuro.2010.05.009
   Bourgeois C, 1998, J VIROL, V72, P7221
   Brosnan J. T., 1998, P INT S GLUT 12 14 O
   BROSNAN JT, 1983, AM J PHYSIOL, V244, pE151
   Brown GC, 2004, BBA-BIOENERGETICS, V1658, P44, DOI 10.1016/j.bbabio.2004.06.016
   Bukelis I, 2007, AM J PSYCHIAT, V164, P1655, DOI 10.1176/appi.ajp.2007.07020315
   Burrus CJ, 2012, MED HYPOTHESES, V79, P784, DOI 10.1016/j.mehy.2012.08.029
   Campbell A, 2004, J NEUROSCI RES, V75, P565, DOI 10.1002/jnr.10877
   Careaga M, 2010, NEUROTHERAPEUTICS, V7, P283, DOI 10.1016/j.nurt.2010.05.003
   Caronna EB, 2008, ARCH DIS CHILD, V93, P518, DOI 10.1136/adc.2006.115337
   Cauwels A, 2006, J CLIN INVEST, V116, P2244, DOI 10.1172/JCI25426
   Chai BH, 2009, J PHYS CHEM B, V113, P13953, DOI 10.1021/jp908163w
   Chai BH, 2008, J PHYS CHEM A, V112, P2242, DOI 10.1021/jp710105n
   Chen CA, 2010, NATURE, V468, P1115, DOI 10.1038/nature09599
   CHOI DW, 1994, PROG BRAIN RES, V100, P47
   Clayton TA, 2012, FEBS LETT, V586, P956, DOI 10.1016/j.febslet.2012.01.049
   Clayton TA, 2009, P NATL ACAD SCI USA, V106, P14728, DOI 10.1073/pnas.0904489106
   Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008
   COTTON DB, 1992, AM J OBSTET GYNECOL, V166, P1127
   Creten C, 2011, LANCET, V378, P98, DOI 10.1016/S0140-6736(11)60548-5
   Cummings JH, 1997, CLIN NUTR, V16, P3, DOI 10.1016/S0261-5614(97)80252-X
   Cunningham C, 1998, BIOCHEM J, V330, P939
   Daikhin Y., 1998, P INT S GLUT 12 14 O
   Dalmau J, 2008, LANCET NEUROL, V7, P1091, DOI 10.1016/S1474-4422(08)70224-2
   Davidson RM, 2012, ENTROPY-SWITZ, V14, P1399, DOI 10.3390/e14081399
   Davis W., 2011, WHEAT BELLY LOSE WHE
   Del Giudice E, 2010, WATER-SUI, V2, P566, DOI 10.3390/w2030566
   DELONG GR, 1992, NEUROSCI BIOBEHAV R, V16, P63, DOI 10.1016/S0149-7634(05)80052-1
   Deth R, 2008, NEUROTOXICOLOGY, V29, P190, DOI 10.1016/j.neuro.2007.09.010
   Dettmer K, 2007, ANAL BIOANAL CHEM, V388, P1643, DOI 10.1007/s00216-007-1301-4
   Dufault R, 2012, CLIN EPIGENETICS, V4, DOI 10.1186/1868-7083-4-6
   Dufault R, 2009, BEHAV BRAIN FUNCT, V5, DOI 10.1186/1744-9081-5-44
   DUKE SO, 1978, PLANT SCI LETT, V11, P185, DOI 10.1016/0304-4211(78)90002-0
   Eichhorn E, 1997, J BIOL CHEM, V272, P23031, DOI 10.1074/jbc.272.37.23031
   Elder JH, 2006, J AUTISM DEV DISORD, V36, P413, DOI 10.1007/s10803-006-0079-0
   El-Rahman Sahar S Abd, 2003, Pharmacol Res, V47, P189, DOI 10.1016/S1043-6618(02)00336-5
   Esko JD, 2009, ESSENTIALS GLYCOBIOL
   Ethell IM, 1999, J CELL BIOL, V144, P575, DOI 10.1083/jcb.144.3.575
   Faber S, 2009, BIOMARKERS, V14, P171, DOI 10.1080/13547500902783747
   Famularo G, 2005, MED HYPOTHESES, V65, P1132, DOI 10.1016/j.mehy.2004.09.030
   Farrell RJ, 2002, NEW ENGL J MED, V346, P180, DOI 10.1056/NEJMra010852
   Fattal-Valevski A, 2009, NEUROLOGY, V73, P828, DOI 10.1212/WNL.0b013e3181b121f5
   Findling RL, 1997, J AUTISM DEV DISORD, V27, P467, DOI 10.1023/A:1025861522935
   Finegold SM, 2011, MED HYPOTHESES, V77, P270, DOI 10.1016/j.mehy.2011.04.032
   Finegold SM, 2002, CLIN INFECT DIS, V35, pS6, DOI 10.1086/341914
   Finegold SM, 2012, ANAEROBE, V18, P260, DOI 10.1016/j.anaerobe.2011.12.018
   Foran E, 2009, ANTIOXID REDOX SIGN, V11, P1587, DOI 10.1089/ars.2009.2444
   Frosini M, 2007, PROG BRAIN RES, V162, P449, DOI 10.1016/S0079-6123(06)62022-0
   FUKAHORI M, 1990, BRAIN RES, V529, P16, DOI 10.1016/0006-8993(90)90806-M
   Fukushima M, 2005, IEEE T MAGN, V41, P4188, DOI 10.1109/TMAG.2005.854842
   Fukushima M., 2002, Transactions of the Magnetics Society of Japan, V2
   Fulton D, 2001, J PHARMACOL EXP THER, V299, P818
   Gabis L, 2005, EPILEPSY BEHAV, V7, P652, DOI 10.1016/j.yebeh.2005.08.008
   Gable MS, 2009, EUR J CLIN MICROBIOL, V28, P1421, DOI 10.1007/s10096-009-0799-0
   Geier DA, 2009, J NEUROL SCI, V280, P101, DOI 10.1016/j.jns.2008.08.021
   George M, 2010, PEDIATR EMERG CARE, V26, P370, DOI 10.1097/PEC.0b013e3181db2237
   Ghaziuddin M, 2002, EUR CHILD ADOLES PSY, V11, P142, DOI 10.1007/s00787-002-0271-5
   Gilberg I.C., 1986, J AUTISM DEV DISORD, V16, P369
   Good P, 2011, MED HYPOTHESES, V77, P1015, DOI 10.1016/j.mehy.2011.08.038
   Grant W.B., 2012, DERMATOENDO IN PRESS, V4
   Gratton JP, 2000, J BIOL CHEM, V275, P22268, DOI 10.1074/jbc.M001644200
   GUCKENBERGER R, 1994, SCIENCE, V266, P1538, DOI 10.1126/science.7985024
   Gulbins E, 2004, J MOL MED-JMM, V82, P357, DOI 10.1007/s00109-004-0539-y
   HALLAK M, 1992, AM J OBSTET GYNECOL, V167, P1605
   Hampton MB, 1998, BLOOD, V92, P3007
   Hansen SH, 2010, J BIOMED SCI, V17, DOI 10.1186/1423-0127-17-S1-S23
   Hartzell S, 2012, ENTROPY-SWITZ, V14, P1953, DOI 10.3390/e14101953
   HASHIMOTO Y, 1992, J BIOL CHEM, V267, P15744
   HEAFIELD MT, 1990, NEUROSCI LETT, V110, P216, DOI 10.1016/0304-3940(90)90814-P
   Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9
   Herrmann KM, 1999, ANNU REV PLANT PHYS, V50, P473, DOI 10.1146/annurev.arplant.50.1.473
   HOAGLAND RE, 1980, WEED SCI, V28, P393
   HORAN FE, 1950, J CLIN INVEST, V29, P202, DOI 10.1172/JCI102247
   Horvath K, 1999, J PEDIATR-US, V135, P559, DOI 10.1016/S0022-3476(99)70052-1
   HOYUMPA AM, 1980, AM J CLIN NUTR, V33, P2750
   Hsueh YP, 1999, J NEUROSCI, V19, P7415
   Huber JD, 2001, TRENDS NEUROSCI, V24, P719, DOI 10.1016/S0166-2236(00)02004-X
   Irie F, 2012, P NATL ACAD SCI USA, V109, P5052, DOI 10.1073/pnas.1117881109
   Ivanov A, 2006, J PHYSIOL-LONDON, V572, P789, DOI 10.1113/jphysiol.2006.105510
   James SJ, 2008, J AUTISM DEV DISORD, V38, P1966, DOI 10.1007/s10803-008-0591-5
   James SJ, 2004, AM J CLIN NUTR, V80, P1611
   Jayakumar AR, 2006, J NEUROSCI, V26, P4774, DOI 10.1523/JNEUROSCI.0120-06.2006
   Johnson S, 2001, MED HYPOTHESES, V56, P163, DOI 10.1054/mehy.2000.1133
   Johnson VJ, 2003, NEUROTOXICOLOGY, V24, P261, DOI 10.1016/S0161-813X(02)00194-8
   Jyonouchi H, 2005, J PEDIATR-US, V146, P605, DOI 10.1016/j.peds.2005.01.027
   Kaya M, 2001, CAN J PHYSIOL PHARM, V79, P793, DOI 10.1139/cjpp-79-9-793
   Kent L, 2008, J MED GENET, V45, P519, DOI 10.1136/jmg.2008.057729
   Khalili H, 2012, GUT, V61, P1686, DOI 10.1136/gutjnl-2011-301574
   KIMELBERG HK, 1990, J NEUROSCI, V10, P1583
   Kleinbongard P, 2006, BLOOD, V107, P2943, DOI 10.1182/blood-2005-10-3992
   Kovacs R, 2009, J NEUROSCI, V29, P8565, DOI 10.1523/JNEUROSCI.5698-08.2009
   Kunz WS, 2000, ANN NEUROL, V48, P766, DOI 10.1002/1531-8249(200011)48:5<766::AID-ANA10>3.0.CO;2-M
   LaSalle J.M., 2001, EPIGENETICS, V6, P862
   Lauri SE, 1999, J NEUROSCI, V19, P1226
   Le Bouguenec C, 2011, INT J MED MICROBIOL, V301, P1, DOI 10.1016/j.ijmm.2010.04.021
   Lelong E, 2011, CELL MICROBIOL, V13, P246, DOI 10.1111/j.1462-5822.2010.01532.x
   Levine B, 2011, NATURE, V469, P323, DOI 10.1038/nature09782
   Li HY, 1999, J BIOL CHEM, V274, P21276, DOI 10.1074/jbc.274.30.21276
   Lia X., 2009, J NEUROIMMUNOL, V201, P111
   Liu LM, 2001, NATURE, V410, P490, DOI 10.1038/35068596
   Lonsdale D, 2002, NEUROENDOCRINOL LETT, V23, P303
   Mak IT, 1996, AM J PHYSIOL-CELL PH, V271, pC385
   Markovitch O, 2008, J PHYS CHEM B, V112, P9456, DOI 10.1021/jp804018y
   Massieu L, 2004, NEUROCHEM RES, V29, P73, DOI 10.1023/B:NERE.0000010435.06586.e2
   Master S, 1999, HEPATOLOGY, V30, P876, DOI 10.1002/hep.510300428
   MATTIOLI S, 1988, JPEN-PARENTER ENTER, V12, P626, DOI 10.1177/0148607188012006626
   Mayer B, 1998, J BIOL CHEM, V273, P3264, DOI 10.1074/jbc.273.6.3264
   McCully K.S., 2011, ANN CLIN LAB SCI, V41, P300
   McCusker KP, 2009, TETRAHEDRON LETT, V50, P611, DOI 10.1016/j.tetlet.2008.11.063
   MCENTEE WJ, 1993, PSYCHOPHARMACOLOGY, V111, P391, DOI 10.1007/BF02253527
   Melo TM, 2006, J CEREBR BLOOD F MET, V26, P1496, DOI 10.1038/sj.jcbfm.9600300
   Michalowicz J, 2007, POL J ENVIRON STUD, V16, P347
   Ming X, 2012, J PROTEOME RES, V11, P5856, DOI 10.1021/pr300910n
   Misra UK, 2008, NEUROL ASIA, V13, P1
   Mizushima N, 2007, GENE DEV, V21, P2861, DOI 10.1101/gad.1599207
   Monfort P, 2002, METAB BRAIN DIS, V17, P237, DOI 10.1023/A:1021993431443
   Montagnier L., 2009, INTERDISCIP SCI COMP, V1, P89
   MOORE JK, 1983, APPL ENVIRON MICROB, V46, P316
   Moseley R, 1997, BBA-MOL BASIS DIS, V1362, P221, DOI 10.1016/S0925-4439(97)00083-5
   Moss Margaret, 2003, Journal of Nutritional & Environmental Medicine (Abingdon), V13, P215, DOI 10.1080/13590840310001642003
   Mousain-Bosc M, 2006, MAGNESIUM RES, V19, P53
   Mundy WR, 1997, MOL CHEM NEUROPATHOL, V32, P41, DOI 10.1007/BF02815166
   Munoz MD, 2000, NEUROCHEM RES, V25, P437, DOI 10.1023/A:1007547622844
   Munoz S, 2010, BIOELECTROCHEMISTRY, V77, P158, DOI 10.1016/j.bioelechem.2009.07.006
   MURCH SH, 1993, LANCET, V341, P711, DOI 10.1016/0140-6736(93)90485-Y
   MUSHAK P, 1989, ENVIRON RES, V50, P11, DOI 10.1016/S0013-9351(89)80046-5
   Nayak P., 2001, Food and Chemical Toxicology, V39, P1285, DOI 10.1016/S0278-6915(01)00077-1
   NEUFELD EF, 1991, ANNU REV BIOCHEM, V60, P257, DOI 10.1146/annurev.bi.60.070191.001353
   Nicolson GL, 2007, J NEUROSCI RES, V85, P1143, DOI 10.1002/jnr.21203
   Nlu M., 1980, MIKROBIOLOGIYA, V49, P269
   Norenberg MD, 2007, METAB BRAIN DIS, V22, P219, DOI 10.1007/s11011-007-9062-5
   Noseworthy MD, 2000, P SOC EXP BIOL MED, V223, P175, DOI 10.1046/j.1525-1373.2000.22324.x
   Oja SS, 1996, METAB BRAIN DIS, V11, P153, DOI 10.1007/BF02069502
   Oller Jr. J.W., 2010, AUTISM DIAGNOSIS TRE
   Olszowski S, 2002, AMINO ACIDS, V22, P145, DOI 10.1007/s007260200003
   OTEIZA PI, 1994, ARCH BIOCHEM BIOPHYS, V308, P374, DOI 10.1006/abbi.1994.1053
   OURY TD, 1993, J BIOL CHEM, V268, P15394
   Palkova Z, 2003, INT REV CYTOL, V225, P229, DOI 10.1016/S0074-7696(05)25006-4
   Poling JS, 2006, J CHILD NEUROL, V21, P170, DOI 10.2310/7010.2006.00032
   Pollack GH, 2009, INT J MOL SCI, V10, P1419, DOI 10.3390/ijms10041419
   Pothoulakis C, 2000, ANN NY ACAD SCI, V915, P347
   Rasalam AD, 2005, DEV MED CHILD NEUROL, V47, P551, DOI 10.1017/S0012162205001076
   Rasmussen-Lathrop SJ, 2000, CELL MICROBIOL, V2, P137, DOI 10.1046/j.1462-5822.2000.00039.x
   Reitsma S, 2007, PFLUG ARCH EUR J PHY, V454, P345, DOI 10.1007/s00424-007-0212-8
   Richerson GB, 2004, NAT REV NEUROSCI, V5, P449, DOI 10.1038/nrn1409
   Rinaldi T, 2007, P NATL ACAD SCI USA, V104, P13501, DOI 10.1073/pnas.0704391104
   Rink L, 2001, BIOMETALS, V14, P367, DOI 10.1023/A:1012986225203
   Rohwerder T, 2003, MICROBIOL-SGM, V149, P1699, DOI 10.1099/mic.0.26212-0
   Romero-Vives M., 1998, Journal of Sleep Research, V7, P228
   Rosenberg GA, 2012, J CEREBR BLOOD F MET, V32, P1139, DOI 10.1038/jcbfm.2011.197
   ROSS MA, 1992, BIOCHEM J, V286, P717
   Ruff J, 2003, BIOCHEM J, V369, P275, DOI 10.1042/BJ20021455
   Schoch HJ, 2002, BRAIN, V125, P2549, DOI 10.1093/brain/awf257
   SCHRAUFSTATTER IU, 1990, J CLIN INVEST, V85, P554, DOI 10.1172/JCI114472
   SCHUBERT J, 1978, J TOXICOL ENV HEALTH, V4, P763
   Schuller-Levis GB, 2004, NEUROCHEM RES, V29, P117, DOI 10.1023/B:NERE.0000010440.37629.17
   SELYE H, 1955, Laryngoscope, V65, P500
   Seneff S, 2012, ENTROPY-SWITZ, V14, P2492, DOI 10.3390/e14122492
   Seneff S, 2012, ENTROPY-SWITZ, V14, P2227, DOI 10.3390/e14112227
   Seneff S, 2012, ENTROPY-SWITZ, V14, P2265, DOI 10.3390/e14112265
   Seneff S, 2012, MED HYPOTHESES, V78, P213, DOI 10.1016/j.mehy.2011.10.026
   Sharifi AM, 2002, NEUROSCI LETT, V329, P45, DOI 10.1016/S0304-3940(02)00576-1
   Shehata A.A., 2012, CURR MICROB IN PRESS
   Shinohe A, 2006, PROG NEURO-PSYCHOPH, V30, P1472, DOI 10.1016/j.pnpbp.2006.06.013
   SIEGEL N, 1983, BIOCHIM BIOPHYS ACTA, V744, P36, DOI 10.1016/0167-4838(83)90337-0
   Sikora DM, 2006, AM J MED GENET A, V140A, P1511, DOI 10.1002/ajmg.a.31294
   Skowronska M, 2012, NEUROTOX RES, V21, P236, DOI 10.1007/s12640-011-9269-4
   Stamatovic SM, 2008, CURR NEUROPHARMACOL, V6, P179, DOI 10.2174/157015908785777210
   Stern Michael, 2011, Front Endocrinol (Lausanne), V2, P54, DOI 10.3389/fendo.2011.00054
   Strambi M, 2006, BIOL TRACE ELEM RES, V109, P97, DOI 10.1385/BTER:109:2:097
   STURMAN JA, 1975, J NUTR, V105, P1206
   Sutherland GR, 2008, MED CHEM, V4, P379, DOI 10.2174/157340608784872235
   Sweeten TL, 2004, BIOL PSYCHIAT, V55, P434, DOI 10.1016/j.biopsych.200309.001
   Tarabeux J, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.52
   Theoharides TC, 2008, J CLIN PSYCHOPHARM, V28, P479, DOI 10.1097/JCP.0b013e3181845f48
   Theoharides TC, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-168
   Tomljenovic L, 2011, J INORG BIOCHEM, V105, P1489, DOI 10.1016/j.jinorgbio.2011.08.008
   Tomljenovic L, 2011, CURR MED CHEM, V18, P2630
   Tordjman S, 2001, MOL PSYCHIATR, V6, P434, DOI 10.1038/sj.mp.4000873
   Tsunoda M, 1999, ARCH TOXICOL, V73, P419, DOI 10.1007/s002040050630
   Valstar MJ, 2010, J INHERIT METAB DIS, V33, P759, DOI 10.1007/s10545-010-9199-y
   van der Ploeg JR, 2001, ARCH MICROBIOL, V176, P1, DOI 10.1007/s002030100298
   Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315
   Verdel N, 2011, INT J MOL SCI, V12, P7481, DOI 10.3390/ijms12117481
   Viorritto ICB, 2007, CLIN IMMUNOL, V122, P125, DOI 10.1016/j.clim.2006.07.012
   Vogl-Willis CA, 2004, BBA-GEN SUBJECTS, V1672, P36, DOI 10.1016/j.bbagen.2004.02.005
   Vojdani A, 2003, INT J IMMUNOPATH PH, V16, P189
   Wadzinski J, 2007, J AM BOARD FAM MED, V20, P499, DOI 10.3122/jabfm.2007.05.070062
   Wakefield AJ, 2002, J PEDIATR GASTR NUTR, V34, pS14, DOI 10.1097/00005176-200205001-00004
   Wakefield AJ, 2002, ALIMENT PHARM THER, V16, P663, DOI 10.1046/j.1365-2036.2002.01206.x
   Waring R. H., 2000, Journal of Nutritional and Environmental Medicine (Abingdon), V10, P25, DOI 10.1080/13590840050000861
   Watanabe Seiji, 2009, No To Hattatsu, V41, P43
   Westall FC, 2006, J CLIN MICROBIOL, V44, P2099, DOI 10.1128/JCM.02532-05
   WESTERGAARD N, 1994, NEUROSCI LETT, V176, P105, DOI 10.1016/0304-3940(94)90882-6
   Williams G, 2001, DEV MED CHILD NEUROL, V43, P202, DOI 10.1017/S001216220100038X
   Wills S, 2009, BRAIN BEHAV IMMUN, V23, P64, DOI 10.1016/j.bbi.2008.07.007
   Xaio HP, 2001, BRAIN RES, V896, P36, DOI 10.1016/S0006-8993(00)03247-9
   Xu DZ, 2002, SHOCK, V17, P139, DOI 10.1097/00024382-200202000-00010
   Yehya N, 2004, J AM ACAD CHILD PSY, V43, P926, DOI 10.1097/01.chi.0000129217.79887.c8
   Zheng JM, 2006, ADV COLLOID INTERFAC, V127, P19, DOI 10.1016/j.cis.2006.07.002
   Zobiole LHS, 2010, PLANT SOIL, V328, P57, DOI 10.1007/s11104-009-0081-3
NR 218
TC 3
Z9 3
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1099-4300
J9 ENTROPY-SWITZ
JI Entropy
PD JAN
PY 2013
VL 15
IS 1
BP 372
EP 406
DI 10.3390/e15010372
PG 35
WC Physics, Multidisciplinary
SC Physics
GA 077IV
UT WOS:000314022000019
ER

PT J
AU Schafer, EC
   Mathews, L
   Mehta, S
   Hill, M
   Munoz, A
   Bishop, R
   Moloney, M
AF Schafer, Erin C.
   Mathews, Lauren
   Mehta, Smita
   Hill, Margaret
   Munoz, Ashley
   Bishop, Rachel
   Moloney, Molly
TI Personal FM systems for children with autism spectrum disorders (ASD)
   and/or attention-deficit hyperactivity disorder (ADHD): An initial
   investigation
SO JOURNAL OF COMMUNICATION DISORDERS
LA English
DT Article
DE Speech recognition; FM system; Autism; Attention-deficit hyperactivity
   disorder; Listening behavior
ID SPEECH-RECOGNITION PERFORMANCE; NOISE; CLASSROOMS; HEARING; ADULTS
AB The goal of this initial investigation was to examine the potential benefit of a frequency modulation (FM) system for 11 Children diagnosed with autism spectrum disorders (ASD), attention-deficit hyperactivity disorder (ADHD), or both disorders through measures of speech recognition performance in noise, observed classroom behavior, and teacher-rated educational risk and listening behaviors. Use of the FM system resulted in significant average improvements in speech recognition in noise for the children with ASD and ADHD as well as large effect sizes. When compared to typically functioning peers, children with ASD and ADHD had significantly poorer average speech recognition performance in noise without the FM system but comparable average performance when the FM system was used. Similarly, classroom observations yielded a significant increase in on-task behaviors and large effect sizes when the FM system was in use during two separate trial periods. Although teacher ratings on questionnaires showed no significant improvement in the average level of educational risk of participants, they did indicate significant improvement in average listening behaviors during two trial periods with the FM system. Given the significantly better speech recognition in noise, increased on-task behaviors, and improved teacher ratings of listening behaviors with the FM system, these devices may be a viable option for children who have ASD and ADHD in the classroom. However, an individual evaluation including audiological testing and a functional evaluation in the child's primary learning environment will be necessary to determine the benefit of an FM system for a particular student.
   Learning Outcomes: 1. The reader will be able to describe the potential benefit of FM systems for children with ASD and/or ADHD. 2. The reader will be able to identify on-task versus off-task listening behaviors in children with ASD and/or ADHD. 3. The reader will be able to explain the components of a successful pre-fit education program that may be necessary prior to fitting an FM system in children with ASD. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Schafer, Erin C.; Mathews, Lauren; Hill, Margaret; Munoz, Ashley; Bishop, Rachel; Moloney, Molly] Univ N Texas, Dept Speech & Hearing Sci, Denton, TX 76203 USA.
   [Mehta, Smita] Univ N Texas, Dept Educ Psychol, Denton, TX 76203 USA.
RP Schafer, EC (reprint author), Univ N Texas, Dept Speech & Hearing Sci, 1155 Union Circle 305010, Denton, TX 76203 USA.
EM Erin.Schafer@unt.edu
FU Phoank AG in Switzerland
FX Funding for a research assistant and supplies for this study was
   graciously provided through a grant from Phoank AG in Switzerland.
   Subjects in this study were not paid for their participation; FM system
   equipment was loaned to the examiners for the study by Phonak AG.
   Appreciation is also expressed to Katherine Algier for her editing of
   this manuscript.
CR Alcantara J. I., 2004, J CHILD PSYCHOL PSYC, V45, P1107
   American Academy of Audiology, 2008, CLIN PRACT GUID REM
   American National Standards Institute, 2010, AC PERF CRIT DES R 1
   American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   American Speech-Language-Hearing Association, 2005, AC ED SETT POS STAT
   American Speech-Language-Hearing Association, 2005, CENTR AUD PROC DIS R
   Anderson K., 2005, J ED AUDIOL, V12, P14
   Anderson K. L., 1996, SCREENING INSTRUMENT
   Ashburner J, 2008, AM J OCCUP THER, V62, P564
   Barry RJ, 2002, CLIN NEUROPHYSIOL, V113, P579, DOI 10.1016/S1388-2457(02)00036-6
   Blake R, 1991, LANG SPEECH HEAR SER, V22, P111
   Centers for Disclose Control and Prevention (CDC), 2009, MMWR RECOMM REP, V58, P1
   Centers for Disease Control and Prevention (CDC) Division of Birth Defects National Center on Birth Defects and Developmental Disabilities, AUT SPECTR DIS DAT S
   Centers for Disease Control and Prevention (CDC) Division of Human Development National Center on Birth Defects and Developmental Disabilities, ATT DEF HYP DIS DAT
   Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
   Corbett BA, 2006, CHILD NEUROPSYCHOL, V12, P335, DOI 10.1080/09297040500350938
   Dunlap WP, 1996, PSYCHOL METHODS, V1, P170, DOI 10.1037//1082-989X.1.2.170
   Etymotic Research, 2005, BAMF KOW BENCH SPEEC
   Flexer C., 1990, LANG SPEECH HEAR SER, V21, P177
   Friederichs E., 2005, J ED AUDIOL, V12, P29
   Gomez R, 1999, J LEARN DISABIL, V32, P150, DOI 10.1177/002221949903200205
   Hedges L, 1985, STAT METHODS METAANA
   HOWARD GS, 1980, EVALUATION REV, V4, P93, DOI 10.1177/0193841X8000400105
   Jamieson Donald G, 2004, J Am Acad Audiol, V15, P508, DOI 10.3766/jaaa.15.7.5
   Johnston KN, 2009, INT J AUDIOL, V48, P371, DOI 10.1080/14992020802687516
   Knecht Heather A, 2002, Am J Audiol, V11, P65, DOI 10.1044/1059-0889(2002/009)
   Lam TCM, 2003, AM J EVAL, V24, P65, DOI 10.1177/109821400302400106
   Larsen JB, 2008, LANG SPEECH HEAR SER, V39, P451, DOI 10.1044/0161-1461(2008/07-0032)
   Mangeot SD, 2001, DEV MED CHILD NEUROL, V43, P399, DOI 10.1017/S0012162201000743
   Neuman AC, 2010, EAR HEARING, V31, P336, DOI 10.1097/AUD.0b013e3181d3d514
   NILSSON M, 1994, J ACOUST SOC AM, V95, P1085, DOI 10.1121/1.408469
   Pastor PN, 2008, VITAL HLTH STAT, V10, P1
   Russo N, 2009, DEVELOPMENTAL SCI, V12, P557, DOI 10.1111/j.1467-7687.2008.00790.x
   Russo N, 2009, J AUTISM DEV DISORD, V39, P1185, DOI 10.1007/s10803-009-0737-0
   SANDERS DA, 1965, EXCEPT CHILDREN, V31, P344
   Schafer E. C., 2003, J ED AUDIOL, V11, P15
   Schafer EC, 2009, INT J AUDIOL, V48, P196, DOI 10.1080/14992020802572635
   SMITH DEP, 1985, J AUTISM DEV DISORD, V15, P285, DOI 10.1007/BF01531499
   Smoski W., 1998, CHAPS CHILDRENS AUDI
   Smoski W. J., 1992, LANG SPEECH HEAR SER, V23, P145
   Syntrillium Software, 2003, COOL ED PROV 2
   Tomchek SD, 2007, AM J OCCUP THER, V61, P190
NR 42
TC 3
Z9 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0021-9924
J9 J COMMUN DISORD
JI J. Commun. Disord.
PD JAN-FEB
PY 2013
VL 46
IS 1
BP 30
EP 52
DI 10.1016/j.jcomdis.2012.09.002
PG 23
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 078ZS
UT WOS:000314140200003
PM 23123089
ER

PT J
AU Sanmaneechai, O
   Sogawa, Y
   Silver, W
   Ballaban-Gil, K
   Moshe, SL
   Shinnar, S
AF Sanmaneechai, Oranee
   Sogawa, Yoshimi
   Silver, Wendy
   Ballaban-Gil, Karen
   Moshe, Solomon L.
   Shinnar, Shlomo
TI Treatment Outcomes of West Syndrome in Infants With Down Syndrome
SO PEDIATRIC NEUROLOGY
LA English
DT Article
ID TUBEROUS SCLEROSIS COMPLEX; AUTISM SPECTRUM DISORDERS; SPASMS; CHILDREN
AB West syndrome constitutes the most frequent of all seizure types in infants with Down syndrome. We retrospectively reviewed records of 12 infants with Down syndrome and West syndrome, accounting for 5% of 239 infants with West syndrome from a comprehensive epilepsy database during a 17-year period. All demonstrated classic hypsarrhythmia on video electroencephalograms. One had clinically responded to clonazepam, and one was not treated because the parents refused any treatment. Seven of 10 infants demonstrated a complete response to high-dose natural adrenocorticotrophic hormone. Four (57%) of these seven infants relapsed. Relapses occurred as long as 2 years after cessation of the initial presentation of infantile spasms. At most recent follow-up (median age, 5 years), 8/12 (67%) were seizure-free, and seven were off any medications. Two of three nonresponders manifested intractable epilepsy and profound mental retardation. Developmentally, 6/8 who could be assessed met criteria for autistic spectrum disorder. Close follow-up is necessary even after successful initial treatment, because relapses are frequent and can occur as long as 2 years later. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Sanmaneechai, Oranee; Sogawa, Yoshimi; Silver, Wendy; Ballaban-Gil, Karen; Moshe, Solomon L.; Shinnar, Shlomo] Albert Einstein Coll Med, Saul R Korey Dept Neurol, Bronx, NY 10467 USA.
   [Sanmaneechai, Oranee; Sogawa, Yoshimi; Silver, Wendy; Ballaban-Gil, Karen; Moshe, Solomon L.; Shinnar, Shlomo] Montefiore Med Ctr, Bronx, NY 10467 USA.
   [Sogawa, Yoshimi; Silver, Wendy; Ballaban-Gil, Karen; Moshe, Solomon L.; Shinnar, Shlomo] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA.
   [Sogawa, Yoshimi; Ballaban-Gil, Karen; Moshe, Solomon L.; Shinnar, Shlomo] Albert Einstein Coll Med, Montefiore Einstein Epilepsy Management Ctr, Bronx, NY 10467 USA.
   [Moshe, Solomon L.] Albert Einstein Coll Med, Lab Dev Epilepsy, Bronx, NY 10467 USA.
   [Moshe, Solomon L.] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10467 USA.
   [Moshe, Solomon L.; Shinnar, Shlomo] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
RP Sanmaneechai, O (reprint author), Univ Iowa Hosp & Clin, Dept Neurol, 200 Hawkins Dr, Iowa City, IA 52242 USA.
EM oranee141@gmail.com
CR Bolton PF, 2002, BRAIN, V125, P1247, DOI 10.1093/brain/awf124
   DiGuiseppi C, 2010, J DEV BEHAV PEDIATR, V31, P181, DOI 10.1097/DBP.0b013e3181d5aa6d
   DYKENS EM, 1994, AM J MENT RETARD, V98, P580
   Eisermann MM, 2003, EPILEPSY RES, V55, P21, DOI 10.1016/S0920-1211(30)00088-3
   Goh S, 2005, NEUROLOGY, V65, P235, DOI 10.1212/01.wnl.0000168908.78118.99
   Goldberg-Stern H, 2001, BRAIN DEV-JPN, V23, P375, DOI 10.1016/S0387-7604(01)00239-X
   Kivity S, 2004, EPILEPSIA, V45, P255, DOI 10.1111/j.0013-9580.2004.30503.x
   LOMBROSO CT, 1983, EPILEPSIA, V24, P135, DOI 10.1111/j.1528-1157.1983.tb04874.x
   Nabbout R, 2001, EPILEPSIA, V42, P1580, DOI 10.1046/j.1528-1157.2001.13501.x
   Osborne JP, 2010, EPILEPSIA, V51, P2168, DOI 10.1111/j.1528-1167.2010.02695.x
   POLLACK MA, 1978, ANN NEUROL, V3, P406, DOI 10.1002/ana.410030508
   PUESCHEL SM, 1991, ARCH NEUROL-CHICAGO, V48, P318
   Romano C, 1990, Am J Med Genet Suppl, V7, P298
   Silva ML, 1996, EPILEPSIA, V37, P977, DOI 10.1111/j.1528-1157.1996.tb00535.x
   STAFSTROM CE, 1994, DEV MED CHILD NEUROL, V36, P576
   TATSUNO M, 1984, BRAIN DEV-JPN, V6, P37
   Yanagaki S, 1999, BRAIN DEV-JPN, V21, P461, DOI 10.1016/S0387-7604(99)00053-4
NR 17
TC 2
Z9 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0887-8994
J9 PEDIATR NEUROL
JI Pediatr. Neurol.
PD JAN
PY 2013
VL 48
IS 1
BP 42
EP 47
DI 10.1016/j.pediatrneurol.2012.09.006
PG 6
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 079VC
UT WOS:000314199300008
PM 23290019
ER

PT J
AU Kose, S
   Bora, E
   Erermis, S
   Ozbaran, B
   Bildik, T
   Aydin, C
AF Kose, Sezen
   Bora, Emre
   Erermis, Serpil
   Ozbaran, Burcu
   Bildik, Tezan
   Aydin, Cahide
TI Broader autistic phenotype in parents of children with autism: Autism
   Spectrum Quotient-Turkish version
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
DE autism; Autism Spectrum Quotient; broader autism phenotype
ID PERVASIVE DEVELOPMENTAL DISORDERS; FUNCTIONING AUTISM;
   BEHAVIOR-CHECKLIST; FAMILY-HISTORY; AQ; INDIVIDUALS; PERSONALITY;
   POPULATION; VALIDITY; TRAITS
AB Aims The Autism Spectrum Quotient (AQ) is a self-assessment screening instrument for measuring the degree to which an individual of normal intelligence shows autistic traits. Genetic factors could be responsible for the relatives of individuals with autism exhibiting higher than normal rates of autism-related impairments, referred to as the broader autism phenotype (BAP). The aim of this study was to test whether there is a difference between the parents of autistic and those of typically developing children (TDC) on AQ scores in a Turkish sample. Method The AQ total and subscale scores of the 100 parents (47 fathers, 53 mothers) of children with autistic disorder (AD) were compared with the 100 parents (48 fathers, 52 mothers) of TDC. Results The parents of AD children scored significantly higher than the TDC parents on total AQ score, and two of five subscale scores; social skills, and communication. The other three subscales (attention to detail, attention switching, imagination) did not differentiate groups. There was no significant difference between mothers and fathers on any AQ scores, neither in the AD nor TDC group. The group X gender interaction was not significant on the total or the five subscale scores of AQ. Conclusion Social skill and communication subscales differentiate AD parents more successfully, and are more sensitive, as reported in other studies. The present findings confirm that social skill and communication impairments in parents of children with autism spectrum disorders are indicators of BAP.
C1 [Kose, Sezen; Erermis, Serpil; Ozbaran, Burcu; Bildik, Tezan; Aydin, Cahide] Ege Univ, Sch Med, Child & Adolescent Psychiat Dept, Izmir, Turkey.
   [Bora, Emre] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia.
RP Kose, S (reprint author), Ege Univ, Tip Fak, Cocuk & Ergen Psikiyatrisi Anabilim Dali, TR-35040 Bornova, Turkey.
EM sezengokcen@hotmail.com
RI bora, emre/D-4123-2009
CR Achenbach T. M., 1983, MANUAL CHILD BEHAV C
   Achenbach T M, 2000, Pediatr Rev, V21, P265, DOI 10.1542/pir.21-8-265
   American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
   Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022
   Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z
   Bailey A, 1998, J AUTISM DEV DISORD, V28, P369, DOI 10.1023/A:1026048320785
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   BARONA A, 1984, J CONSULT CLIN PSYCH, V52, P885, DOI 10.1037/0022-006X.52.5.885
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6
   Bayliss AP, 2005, BRIT J PSYCHOL, V96, P95, DOI 10.1348/000712604X15626
   Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x
   BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x
   Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294
   Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2
   Duarte CS, 2003, J AUTISM DEV DISORD, V33, P703, DOI 10.1023/B:JADD.0000006005.31818.1c
   Erol N, 1995, EUNETHYDIS EUROPEAN, P97
   FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x
   Gerdts J, 2011, AUTISM RES TREAT, V2011, P1
   Gomot M, 2008, BRAIN, V131, P2479, DOI 10.1093/brain/awn172
   Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x
   Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372
   Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3
   Hutzelmeyer-Nickels A, 2007, PRAX KINDERPSYCHOL K, V56, P573
   Kanner L., 1957, PSYCHIAT RES REP AM, V7, P55
   Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895
   Kose S, 2010, ANADOLU PSIKIYATR DE, V11, P253
   LANDA R, 1992, PSYCHOL MED, V22, P245
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Losh M, 2007, J CHILD PSYCHOL PSYC, V48, P105, DOI 10.1111/j.1469-7610.2006.01594.x
   Noterdaeme M, 1999, Z KINDER JUG-PSYCH, V27, P183, DOI 10.1024//1422-4917.27.3.183
   Pickles A, 2000, J CHILD PSYCHOL PSYC, V41, P491, DOI 10.1017/S0021963099005557
   Piven J, 1997, AM J MED GENET, V74, P398, DOI 10.1002/(SICI)1096-8628(19970725)74:4<398::AID-AJMG11>3.0.CO;2-D
   Piven J, 1997, AM J PSYCHIAT, V154, P185
   Ruta L, 2012, J AUTISM DEV DISORD, V42, P625, DOI 10.1007/s10803-011-1290-1
   Scheeren AM, 2008, J AUTISM DEV DISORD, V38, P276, DOI 10.1007/s10803-007-0389-x
   Sung YJ, 2005, AM J HUM GENET, V76, P68, DOI 10.1086/426951
   Veenstra-Vanderweele J, 2003, J AM ACAD CHILD PSY, V42, P116, DOI 10.1097/01.CHI.0000024913.60748.41
   Wakabayashi A, 2006, J AUTISM DEV DISORD, V36, P263, DOI 10.1007/s10803-005-0061-2
   Wheelwright S, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-10
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
NR 42
TC 5
Z9 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD JAN
PY 2013
VL 67
IS 1
BP 20
EP 27
DI 10.1111/pcn.12005
PG 8
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 074QY
UT WOS:000313829200004
PM 23331285
ER

PT J
AU Fingerhut, PE
AF Fingerhut, Patricia E.
TI Life Participation for Parents: A Tool for Family-Centered Occupational
   Therapy
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
ID CONTEMPORARY PRACTICE; HOLISTIC APPROACH; YOUNG-CHILDREN;
   CEREBRAL-PALSY; ADAPTATION; MOTHERS; AUTISM; DISABILITY; IMPACT
AB OBJECTIVE. This study describes the continued development of the Life Participation for Parents (LPP), a measurement tool to facilitate family-centered pediatric practice.
   METHOD. LPP questionnaires were completed by 162 parents of children with special needs receiving intervention at 15 pediatric private practice clinics. Results were analyzed to establish instrument reliability and validity.
   RESULTS. Good internal consistency (alpha = .90) and test-retest reliability (r = .89) were established. Construct validity was examined through assessment of internal structure and comparison of the instrument to related variables. A principal component S analysis resulted in a two-factor model accounting for 43.81% of the variance. As hypothesized, the LPP correlated only moderately with the Parenting Stress Index Short Form (r = .54). The variables of child's diagnoses, age; and time in therapy did not predict parental responses.
   CONCLUSION. The LPP is a reliable and valid instrument for measuring satisfaction with parental participation in life occupations. Fingerhut, P. E. (2013). Life Participation for Parents: A tool for family-centered occupational therapy. American Journal of Occupational Therapy, 67, 37-44. http://dx.doi.org/10.5014/ajot.2013.005082
C1 Univ Texas Med Branch, Dept Occupat Therapy, Sch Hlth Profess, Galveston, TX 77555 USA.
RP Fingerhut, PE (reprint author), Univ Texas Med Branch, Dept Occupat Therapy, Sch Hlth Profess, 301 Univ Blvd, Galveston, TX 77555 USA.
EM pefinger@utmb.edu
CR Abidin RR, 1995, PARENTING STRESS IND
   American Occupational Therapy Association, 2008, AM J OCCUPATIONAL TH, V62, P625, DOI [10.5014/ajot.62.6.625, DOI 10.5014/AJOT.62.6.625]
   Brown T, 2010, HONG KONG J OCCUP TH, V20, P30
   Butcher PR, 2008, CHILD CARE HLTH DEV, V34, P530, DOI 10.1111/j.1365-2214.2008.00842.x
   CADMAN D, 1991, PEDIATRICS, V87, P884
   CROWE TK, 1993, DEV MED CHILD NEUROL, V35, P621
   Field A., 2009, DISCOVERING STAT USI
   Fingerhut P. E., 2005, THESIS TEXAS WOMANS
   Fingerhut PE, 2009, PHYS OCCUP THER PEDI, V29, P113, DOI 10.1080/01942630902784795
   Hinojosa J, 2002, AM J OCCUP THER, V56, P556
   Jaffe L., 2010, OCCUPATIONAL THERAPY, P108
   Jones J, 2004, J DEV DISABILITIES, V11, P31
   Kasari C, 1997, J AUTISM DEV DISORD, V27, P39, DOI 10.1023/A:1025869105208
   Kuhaneck HM, 2010, PHYS OCCUP THER PEDI, V30, P340, DOI 10.3109/01942638.2010.481662
   Magill-Evans J, 2001, DEV MED CHILD NEUROL, V43, P466, DOI 10.1017/S0012162201000858
   Portney LG., 2000, FDN CLIN RES APPL PR
   Raina P, 2005, PEDIATRICS, V115, pE626, DOI 10.1542/peds.2004-1689
   Roberts K, 2001, CHILD CARE HLTH DEV, V27, P307, DOI 10.1046/j.1365-2214.2001.00178.x
   Rosenbaum P., 1998, PHYS OCCUPATIONAL TH, V18, P1, DOI DOI 10.1300/J006V18N01_01
   Schaaf RC, 2011, AUTISM, V15, P373, DOI 10.1177/1362361310386505
   SCHULTZ S, 1992, AM J OCCUP THER, V46, P917
   SCHKADE JK, 1992, AM J OCCUP THER, V46, P829
   Schultz S., 2003, WILLARD SPACKMANS OC, P220
   SLOPER P, 1993, J CHILD PSYCHOL PSYC, V34, P167, DOI 10.1111/j.1469-7610.1993.tb00978.x
   Stewart K, 2010, OCCUPATIONAL THERAPY, P193
NR 25
TC 1
Z9 1
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD JAN-FEB
PY 2013
VL 67
IS 1
BP 37
EP 44
DI 10.5014/ajot.2013.005082
PG 8
WC Rehabilitation
SC Rehabilitation
GA 073UO
UT WOS:000313768800005
PM 23245781
ER

PT J
AU Ben Thabet, J
   Sallemi, R
   Hasiri, I
   Zouari, L
   Kamoun, F
   Zouari, N
   Triki, C
   Maalej, M
AF Ben Thabet, J.
   Sallemi, R.
   Hasiri, I.
   Zouari, L.
   Kamoun, F.
   Zouari, N.
   Triki, C.
   Maalej, M.
TI Psycho-emotional impact of a child's disability on parents
SO ARCHIVES DE PEDIATRIE
LA French
DT Article
ID PSYCHOLOGICAL DISTRESS; GENDER-DIFFERENCES; MOTHERS; FAMILIES; FATHERS;
   STRESS; POPULATION; ADAPTATION; DEPRESSION; AUTISM
AB Care for a child with a disability is a stressful experience for parents. It triggers a range of emotions and feelings that require a set of behaviors and attitudes to manage daily life. To face this situation, parents use coping strategies. The purpose of this study was to assess the psychological reactions (depression and anxiety) of parents and the impact of a child's disability on their quality of life (QOL), and to determine their coping strategies. A survey of 50 parents of handicapped children, treated in the neurology department at the Sfax Teaching Hospital in Tunisia, was conducted in September 2010. The Beck Depression Inventory (BDI), the State Trait Anxiety Inventory (STAI), the SF-36, and the Brief COPE were used to assess, respectively, depression, anxiety, QOL, and coping strategies in parents. Among the group of parents studied, the anxiety and depression rates were, respectively, 68% and 52%. Depression was more frequent among mothers and was correlated with low educational and socioeconomic levels. Anxiety was found in 70.7% of mothers and 55.6% of fathers with no significant correlation. There was a correlation between anxiety and increased family burden related to the presence of a similar case in the family. The range of coping strategies used includes religion (16%), active coping (16%), planning (16%), acceptance (20%), focus and venting of feelings (10%), and seeking emotional social support (10%). Parents used emotion-focused coping in 68% of cases and problem-centered coping in 32% of cases. The coping strategy choice was significantly correlated with gender. Mothers preferentially used emotion-focused coping. Depressed or anxious parents more frequently used emotion-focused strategies. Religious faith was correlated with a strategy centered on religious coping. The length of follow-up (more than 2 years) was correlated with a strategy focused on acceptance. Emotion-focused coping was also correlated with low levels of education and socioeconomic status We found correlations between depression and different types of emotion-focused coping such as emotional support. Impaired QOL was higher among mothers (58.5% versus 33.3%). It was correlated with depression, anxiety, and the use of emotional coping. Also, it was correlated with low educational and socioeconomic levels and increased family burden related to the presence of a similar case in the family. The size most commonly impaired in mothers was limited due to mental health (56.9% versus 44.4% for fathers). Social functioning (D6) was significantly correlated with the presence of a mental disability, the functional dependence of the child, and increased family burden related to the presence of a similar case in the family. Impaired QOL was found in 66.8% of parents dissatisfied with the explanations given by the medical team. More problem-focused coping was found in parents satisfied with the information given by the medical team compared to those inadequately informed (42.1% veksus 25.8%). The presence of a disabled child causes profound changes in the family. The impact of anxiety and depression on parents and on their QOL are considerable. This is a situation that involves an adaptation process. At first, parents may be tempted to use coping strategies focused on religion, a choice related to Arab-Muslim fatalism. Parents should be encouraged to use active coping strategies to support their disabled child better.
   In addition, adequate information given by the healthcare staff would help them to deal with the child's handicap and would contribute to improving their QOL. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Ben Thabet, J.; Sallemi, R.; Zouari, L.; Zouari, N.; Maalej, M.] Univ Sfax, CHU Hedi Chaker, Serv Psychiat C, Fac Med Sfax, Sfax 3029, Tunisia.
   [Hasiri, I.; Kamoun, F.; Triki, C.] Univ Sfax, CHU Hedi Chaker, Serv Neuropediat, Fac Med Sfax, Sfax 3029, Tunisia.
RP Ben Thabet, J (reprint author), Univ Sfax, CHU Hedi Chaker, Serv Psychiat C, Fac Med Sfax, 7 Route El Ain Km, Sfax 3029, Tunisia.
EM kamounjihene@yahoo.fr
CR Allouche C., 2007, THESIS
   BARUSCH AS, 1989, GERONTOLOGIST, V29, P667
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561
   Bishop DS, 1988, J HEAD TRAUMA REHAB, V3, P16, DOI 10.1097/00001199-198812000-00005
   BRESLAU N, 1982, AM J DIS CHILD, V136, P682
   Bumin G, 2008, J S D U FM, V15, P6
   Canoui P, 2004, ARCH PEDIAT S1, V11
   Cappe E, 2009, PSYCHIAT ENFANT, V52, P201
   Drentea Patricia, 2005, ADV LIFE COURSE RES, V9, P303, DOI 10.1016/S1040-2608(04)09011-2
   FREEMAN NL, 1991, J CHILD PSYCHOL PSYC, V32, P1025, DOI 10.1111/j.1469-7610.1991.tb01927.x
   Gray DE, 2006, J INTELL DISABIL RES, V50, P970, DOI 10.1111/j.1365-2788.2006.00933.x
   Gutman DL, 1974, CULTURE PERSONALITY
   Ha JH, 2008, J HEALTH SOC BEHAV, V49, P301
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50
   Hatzmann J., 2008, PEDIATRICS, V122, P1030
   Hoare P, 1998, J INTELL DISABIL RES, V42, P218, DOI 10.1046/j.1365-2788.1998.00134.x
   JENKINSON C, 1994, QUAL LIFE RES, V3, P7, DOI 10.1007/BF00647843
   Keller D, 2004, AM J ORTHOPSYCHIAT, V74, P337, DOI 10.1037/0002-9432.74.3.337
   Khamis V, 2007, SOC SCI MED, V64, P850, DOI 10.1016/j.socscimed.2006.10.022
   Lamarche C, 1985, Sante Ment Que, V10, P36
   Lin LY, 2011, RES AUTISM SPECT DIS, V5, P144, DOI 10.1016/j.rasd.2010.03.004
   MOES D, 1992, PSYCHOL REP, V71, P1272, DOI 10.2466/PR0.71.8.1272-1274
   Muller L, 2003, ENCEPHALE, V29, P507
   Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x
   Pelchat Diane, 2003, J Child Health Care, V7, P231, DOI 10.1177/13674935030074001
   Pelchat D, 1999, INT J NURS STUD, V36, P465, DOI 10.1016/S0020-7489(99)00047-4
   Pruchno R, 1999, RES AGING, V21, P682, DOI 10.1177/0164027599215003
   Ravindranadan V, 2007, J INDIAN ACAD APPL P, V33, P137
   Rogers W. L., 1976, QUALITY AM LIFE
   Ross CE, 1996, J MARRIAGE FAM, V58, P572, DOI 10.2307/353718
   SOMMER K, 1993, DEV PSYCHOL, V29, P389, DOI 10.1037/0012-1649.29.2.389
   Sullivan Anthony, 2002, Downs Syndr Res Pract, V8, P67, DOI 10.3104/reports.132
   Tamres LK, 2002, PERS SOC PSYCHOL REV, V6, P2, DOI 10.1207/S15327957PSPR0601_1
   Veyssiere A, 2010, PRAT PSYCHOL, V3, P239
   Zouari A., 2008, THESIS
NR 35
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD JAN
PY 2013
VL 20
IS 1
BP 9
EP 16
DI 10.1016/j.arcped.2012.10.024
PG 8
WC Pediatrics
SC Pediatrics
GA 074YH
UT WOS:000313850500002
PM 23266169
ER

PT J
AU Poinso, F
   Dubois, B
   Chatel, C
   Viellard, M
   Bastard-Rosset, D
   Girardot, AM
   Grandgeorge, P
   De Martino, S
   Sokolowsky, M
   Salle-Collemiche, X
   Da Fonseca, D
AF Poinso, F.
   Dubois, B.
   Chatel, C.
   Viellard, M.
   Bastard-Rosset, D.
   Girardot, A. -M.
   Grandgeorge, P.
   De Martino, S.
   Sokolowsky, M.
   Salle-Collemiche, X.
   Da Fonseca, D.
TI Prospective assessment of children with pervasive developmental disorder
   after 2 years of day-hospital treatment
SO ARCHIVES DE PEDIATRIE
LA French
DT Article
ID BEHAVIORAL TREATMENT; AUTISM
AB The treatment of children with pervasive developmental disorders (PDD) has not been systematically assessed in French day-care units. In this prospective study, 11 children with a diagnosis of PDD were followed up for 2 years in a day-care unit in the Marseille university hospital. The treatment they received is based on an initial assessment by the "Centre Ressources Autisme" (CRA PACA) and further included a continued observation of the child and an assessment of the child's abilities and needs. This treatment used various therapeutic approaches 10 h weekly and also included parental counseling and coordinated work with schools. Treatment in our day-care unit can be categorized as eclectic, non-intensive therapy. It is based on methods such as TEACCH (Treatment and Education of Autistic and related Communication handicapped Children), Floor Time Play, speech and language therapy, developmental therapy, and psychotherapy. International studies on intensive behavioral therapies suggest that this treatment is superior to non-behavioral and/or non-intensive treatment. They suggest its efficiency is due both to the nature of the treatment (behavioral) and to its intensity (more than 25 h a week). In this study, the CRA diagnosed children using the ADI and ADOS. The 11 children (mean age, 3 years 5 months) were tested twice, with the Vineland and CARS scales. The first assessment was on admission to the day hospital and the second was 2 years later. The results showed developmental progress with a mean increase of 13.5 months at the Vineland Scale, and a decrease of the autism severity score on the CARS. The treatment presented here proves to be efficient; if compared to similar results in international studies, we obtained better results than their eclectic intensive or non-intensive treatment comparison group. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Poinso, F.; Dubois, B.; Sokolowsky, M.; Salle-Collemiche, X.] CHU Marseille, Hop St Marguerite, Serv Pedopsychiat, F-13274 Marseille 09, France.
   [Chatel, C.; Viellard, M.; Bastard-Rosset, D.; Girardot, A. -M.; Grandgeorge, P.; De Martino, S.; Da Fonseca, D.] CHU Marseille, Hop St Marguerite, Ctr Ressource Autisme PACA, Serv Pedopsychiat, F-13274 Marseille 09, France.
RP Poinso, F (reprint author), CHU Marseille, Hop St Marguerite, Serv Pedopsychiat, F-13274 Marseille 09, France.
EM francois.poinso@ap-hm.fr
CR American Psychiatric Association, 2009, DIAGN STAT MAN MENT
   Baghdadli A, 2007, INTERVENTIONS ED PED
   Baghdadli A, 2012, J AUTISM DEV DISORD, V42, P1314, DOI 10.1007/s10803-011-1357-z
   Barthelemy C, 1995, AUTISME ENFANT THERA
   Bibby Peter, 2002, Research in Developmental Disabilities, V23, P81, DOI 10.1016/S0891-4222(02)00095-1
   Bondy A, 2001, BEHAV MODIF, V25, P725, DOI 10.1177/0145445501255004
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Eikeseth S, 2007, BEHAV MODIF, V31, P264, DOI 10.1177/0145445506291396
   Eldevik S, 2006, J AUTISM DEV DISORD, V36, P211
   Gernsbacher MA, 2003, J DEV LEARNING DISOR, V7, P19
   Greenspan SI, 1998, CHILD SPECIAL ENCOUR
   Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005
   Itzchak EB, 2009, RES AUTISM SPECT DIS, V3, P967, DOI DOI 10.1016/J.RASD.2009.05.001
   LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Peters-Scheffer N, 2010, RES DEV DISABIL, V31, P1678, DOI 10.1016/j.ridd.2010.04.008
   Peters-Scheffer N, 2011, RES AUTISM SPECT DIS, V5, P60, DOI 10.1016/j.rasd.2010.03.011
   Pry R, 2007, J AUTISM DEV DISORD, V37, P341, DOI 10.1007/s10803-006-0161-7
   Roeyers H, 1996, J AUTISM DEV DISORD, V26, P303, DOI 10.1007/BF02172476
   Schopler E., 1986, CHILDHOOD AUTISM RAT
   Schopler E, 1988, STRATEGIES ED AUTISM
   SCHOPLER E, 1989, J CONSULT CLIN PSYCH, V57, P162
   Schopler E, 1990, PSYCHOEDUCATIONAL PR
   Smith T, 2000, RES DEV DISABIL, V21, P297, DOI 10.1016/S0891-4222(00)00043-3
   Sparrow S, 1984, VINELAND ADAPTIVE BE
   Walker M., 1980, MVDP RES INFORM SERV
NR 26
TC 0
Z9 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0929-693X
J9 ARCH PEDIATRIE
JI Arch. Pediatr.
PD JAN
PY 2013
VL 20
IS 1
BP 17
EP 25
DI 10.1016/j.arcped.2012.10.014
PG 9
WC Pediatrics
SC Pediatrics
GA 074YH
UT WOS:000313850500003
PM 23219270
ER

PT J
AU Pascoe, JM
AF Pascoe, John M.
TI Autism Spectrum Disorders Foreword
SO CURRENT PROBLEMS IN PEDIATRIC AND ADOLESCENT HEALTH CARE
LA English
DT Editorial Material
CR Manning-Courtney Patricia, 2003, Curr Probl Pediatr Adolesc Health Care, V33, P283, DOI 10.1016/S1538-5442(03)00108-1
NR 1
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1538-5442
J9 CURR PROB PEDIATR AD
JI Curr. Probl. Pediatr. Adolesc. Health Care
PD JAN
PY 2013
VL 43
IS 1
BP 1
EP 1
PG 1
WC Pediatrics
SC Pediatrics
GA 078ZV
UT WOS:000314140600001
PM 23332396
ER

PT J
AU Manning-Courtney, P
   Murray, D
   Currans, K
   Johnson, H
   Bing, N
   Kroeger-Geoppinger, K
   Sorensen, R
   Bass, J
   Reinhold, J
   Johnson, A
   Messerschmidt, T
AF Manning-Courtney, Patricia
   Murray, Donna
   Currans, Kristn
   Johnson, Heather
   Bing, Nicole
   Kroeger-Geoppinger, Kim
   Sorensen, Rena
   Bass, Jennifer
   Reinhold, Judy
   Johnson, Amy
   Messerschmidt, Teri
TI Autism Spectrum Disorders
SO CURRENT PROBLEMS IN PEDIATRIC AND ADOLESCENT HEALTH CARE
LA English
DT Article
ID ALTERNATIVE MEDICINE TREATMENTS; INTENSIVE BEHAVIORAL TREATMENT;
   RECURRENCE RISK; CHILDREN; COMPLEMENTARY; HYPERACTIVITY; ADOLESCENTS;
   PREVALENCE; MANAGEMENT; DIAGNOSIS
AB Autism spectrum disorders are being diagnosed with increasing frequency. The likelihood that a primary care provider will see a patient with autism spectrum disorder in their clinic is high. In this article, current diagnostic criteria and expected changes in DSM criteria, as well as prevalence rates and epidemiologic studies are reviewed. Recommendations for screening, including early warning signs, and best practices for diagnosis are discussed. Comprehensive evidence based intervention for ASD as well as the findings of the National Standards Project are reviewed. Medication management is also described, as are the roles of other treating professionals. Curr Probl Pediatr Adolesc Health Care 2013;43:2-11
C1 [Manning-Courtney, Patricia; Murray, Donna; Currans, Kristn; Johnson, Heather; Bing, Nicole; Kroeger-Geoppinger, Kim; Sorensen, Rena; Bass, Jennifer; Reinhold, Judy; Johnson, Amy; Messerschmidt, Teri] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45221 USA.
RP Manning-Courtney, P (reprint author), Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45221 USA.
CR Al-Qabandi M, 2011, PEDIATRICS, V128, pE211, DOI 10.1542/peds.2010-1881
   Aman MG, 2003, J AUTISM DEV DISORD, V33, P527, DOI 10.1023/A:1025883612879
   American Occupational Therapy Association, 2008, OCC THER PRACT FRAM
   [Anonymous], 2009, MMWR SURVEILLANCE SU, P1
   [Anonymous], 1992, INT STAT CLASS DIS R
   (APA) APA, 2000, DIAGN STAT MAN MENT
   Arnold LE, 2006, J AM ACAD CHILD PSY, V45, P1196, DOI 10.1097/01.chi.0000231976.28719.2a
   Association AS-L-H, 2006, TECHNICAL REPORT
   Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILLANCE SU, V61, P1
   BAILEY A, 1995, PSYCHOL MED, V25, P63
   Center NA, 2009, EV BAS PRACT AUT SCH
   Coury DL, 2011, DIAGNOSIS ASSESSMENT
   Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958
   Detrich R, 2008, EFFECTIVE PRACTICES
   Filipek PA, 2000, NEUROLOGY, V55, P468
   Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493
   Gilman SR, 2011, NEURON, V70, P898, DOI 10.1016/j.neuron.2011.05.021
   Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76
   Happe F, 2011, J AM ACAD CHILD PSY, V50, P540, DOI 10.1016/j.jaac.2011.03.015
   Health NIo, 2011, EST FUND VAR RES CON
   Huffman LC, 2011, J DEV BEHAV PEDIATR, V32, P56, DOI 10.1097/DBP.0b013e3182040acf
   Jasmin E, 2009, J AUTISM DEV DISORD, V39, P231, DOI 10.1007/s10803-008-0617-z
   Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361
   King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30
   King M, 2009, INT J EPIDEMIOL, V38, P1224, DOI 10.1093/ije/dyp261
   Klinger LG, 2009, ASSESSMENT AUTISM SP, P209
   Klinger YS, 2011, AM J PSYCHIAT, V168, P904
   Levy SE, 2008, CHILD ADOL PSYCH CL, V17, P803, DOI 10.1016/j.chc.2008.06.004
   Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694
   LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3
   Malow B, 2012, J AUTISM DEV DISORD, V42, P1729, DOI 10.1007/s10803-011-1418-3
   Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658
   MCEACHIN JJ, 1993, AM J MENT RETARD, V97, P359
   McEachin JJ, 1993, AM J MENT RETARD, V97, P373
   McGee J. P., 2001, ED CHILDREN AUTISM
   McPheeters ML, 2011, PEDIATRICS, V127, pE1312, DOI 10.1542/peds.2011-0427
   Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362
   Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825
   Ozonoff S, 2005, J CLIN CHILD ADOLESC, V34, P523, DOI 10.1207/s15374424jccp3403_8
   Prizant B., 2005, HDB AUTISM PERVASIVE, V2, P925
   Provost B, 2009, NZ J OCCUPATIONAL TH, V56, P9
   McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171
   Aman MG, 2005, ARCH GEN PSYCHIAT, V62, P1266
   RITVO ER, 1989, AM J PSYCHIAT, V146, P1032
   Robins D., 1999, MODIFIED CHECKLIST A
   Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
   Semel E., 2006, CLIN EVALUATION LANG, V4th
   Siegel M, 2012, J AUTISM DEV DISORD, V42, P1592, DOI 10.1007/s10803-011-1399-2
   Singh J, 2009, J AUTISM DEV DISORD, V39, P788, DOI 10.1007/s10803-008-0685-0
   Wilczynski S, NATL STANDARDS REPOR
   Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 51
TC 7
Z9 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1538-5442
J9 CURR PROB PEDIATR AD
JI Curr. Probl. Pediatr. Adolesc. Health Care
PD JAN
PY 2013
VL 43
IS 1
BP 2
EP 11
DI 10.1016/j.cppeds.2012.08.001
PG 10
WC Pediatrics
SC Pediatrics
GA 078ZV
UT WOS:000314140600002
PM 23332397
ER

PT J
AU Solomon, R
AF Solomon, Richard
TI Commentary on 'Autism Spectrum Disorders'
SO CURRENT PROBLEMS IN PEDIATRIC AND ADOLESCENT HEALTH CARE
LA English
DT Editorial Material
ID CONTROLLED-TRIAL; JOINT ATTENTION; YOUNG-CHILDREN; INTERVENTION; PLAY;
   ADOLESCENTS; TODDLERS; LANGUAGE; BEHAVIOR; PROGRAM
C1 Ann Arbor Ctr Dev & Behav Pediat, Ann Arbor, MI 48108 USA.
RP Solomon, R (reprint author), Ann Arbor Ctr Dev & Behav Pediat, Ann Arbor, MI 48108 USA.
EM dr.ricksol@comcast.net
CR Baker JK, 2011, J FAM PSYCHOL, V25, P601, DOI 10.1037/a0024409
   Casenhiser DM, 2011, AUTISM, V1, P1
   Dawson G., 1990, DEV PSYCHOPATHOL, V2, P151, DOI 10.1017/S0954579400000675
   Greenspan S. I., 1997, J DEV LEARNING DISOR, V1, P87
   Hartley SL, 2012, FAM RELAT, V61, P327, DOI 10.1111/j.1741-3729.2011.00693.x
   Ingersoll B., 2005, FOCUS AUTISM OTHER D, V20, P213, DOI DOI 10.1177/10883576050200040301
   Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x
   Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125
   Kasari C, 2010, J AUTISM DEV DI 0210
   Kleinman JM, 2008, J AUTISM DEV DISORD, V38, P827, DOI 10.1007/s10803-007-0450-9
   Krebs-Seida JK, 2009, DEV MED CHILD NEUROL, V51, P95
   Landa RJ, 2011, J CHILD PSYCHOL PSYC, V52, P13, DOI 10.1111/j.1469-7610.2010.02288.x
   Mahoney G, 2005, J DEV BEHAV PEDIATR, V26, P77, DOI 10.1097/00004703-200504000-00002
   McConachie H, 2005, J PEDIATR-US, V147, P335, DOI 10.1016/j.jpeds.2005.03.056
   McGee J. P., 2001, ED CHILDREN AUTISM
   Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755
   Parjareya K, 2011, AUTISM, V15, P1
   Prizant Barry, 1998, Seminars in Speech and Language, V19, P329, DOI 10.1055/s-2008-1064053
   Salt J, 2002, AUTISM, V6, P33, DOI 10.1177/1362361302006001004
   Solomon R, 2007, AUTISM, V11, P205, DOI 10.1177/1362361307076842
   Spreckley M, 2009, J PEDIATR-US, V154, P338, DOI 10.1016/j.jpeds.2008.09.012
   Wakefield AJ, 1998, LANCET, V351, P9103
NR 22
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1538-5442
J9 CURR PROB PEDIATR AD
JI Curr. Probl. Pediatr. Adolesc. Health Care
PD JAN
PY 2013
VL 43
IS 1
BP 12
EP 16
DI 10.1016/j.cppeds.2012.07.005
PG 5
WC Pediatrics
SC Pediatrics
GA 078ZV
UT WOS:000314140600003
PM 23332398
ER

PT J
AU Akhtar, N
   Jaswal, VK
AF Akhtar, Nameera
   Jaswal, Vikram K.
TI Deficit or Difference? Interpreting Diverse Developmental Paths: An
   Introduction to the Special Section
SO DEVELOPMENTAL PSYCHOLOGY
LA English
DT Editorial Material
DE diversity; culture; education; autism
ID LANGUAGE; AUTISM
AB How should differences between "typically developing" children and other populations be interpreted? To what extent should the emphasis be on advocating remediation for children who are on a developmental trajectory that differs from the norm versus embracing different developmental trajectories as equally valid contributions to the diversity of human experience? The 6 target articles and 2 commentaries in this special section offer a diverse set of perspectives on the tensions and responsibilities inherent in interpreting and acting on differences between children of different cultural, ethnic, linguistic, socioeconomic, and neurological backgrounds.
C1 [Akhtar, Nameera] Univ Calif Santa Cruz, Dept Psychol, Santa Cruz, CA 95064 USA.
   [Jaswal, Vikram K.] Univ Virginia, Dept Psychol, Charlottesville, VA 22903 USA.
RP Akhtar, N (reprint author), Univ Calif Santa Cruz, Dept Psychol, Santa Cruz, CA 95064 USA.
EM nakhtar@ucsc.edu
CR Akhtar N, 2012, ADV CHILD DEV BEHAV, V42, P41
   Bialystok E, 2011, CAN J EXP PSYCHOL, V65, P229, DOI 10.1037/a0025406
   Callanan M, 2013, DEV PSYCHOL, V49, P80, DOI 10.1037/a0029741
   Cole M, 2013, DEV PSYCHOL, V49, P84, DOI 10.1037/a0029623
   Diamond A, 2011, SCIENCE, V333, P959, DOI 10.1126/science.1204529
   Enright KA, 2011, AM EDUC RES J, V48, P80, DOI 10.3102/0002831210368989
   Fryberg SA, 2013, DEV PSYCHOL, V49, P72, DOI 10.1037/a0029056
   Henrich J, 2010, BEHAV BRAIN SCI, V33, P61, DOI 10.1017/S0140525X0999152X
   Hoff E, 2013, DEV PSYCHOL, V49, P4, DOI 10.1037/a0027238
   Hurley D., 2012, NY TIMES
   Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x
   Kapp SK, 2013, DEV PSYCHOL, V49, P59, DOI 10.1037/a0028353
   Lederberg AR, 2013, DEV PSYCHOL, V49, P15, DOI 10.1037/a0029558
   Medin D, 2010, PERSPECT PSYCHOL SCI, V5, P708, DOI 10.1177/1745691610388772
   Mottron L, 2011, NATURE, V479, P33, DOI 10.1038/479033a
   Murray S, 2012, AUTISM
   Norbury CF, 2013, DEV PSYCHOL, V49, P45, DOI 10.1037/a0027446
   Pearson BZ, 2013, DEV PSYCHOL, V49, P31, DOI 10.1037/a0028248
   Robison J. E., 2011, BE DIFFERENT ADVENTU
NR 19
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0012-1649
J9 DEV PSYCHOL
JI Dev. Psychol.
PD JAN
PY 2013
VL 49
IS 1
BP 1
EP 3
DI 10.1037/a0029851
PG 3
WC Psychology, Developmental
SC Psychology
GA 069YC
UT WOS:000313472000001
PM 23316772
ER

PT J
AU Norbury, CF
   Sparks, A
AF Norbury, Courtenay Frazier
   Sparks, Alison
TI Difference or Disorder? Cultural Issues in Understanding
   Neurodevelopmental Disorders
SO DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
DE autism; culture; treatment; prevalence; specific language impairment
ID PERVASIVE DEVELOPMENTAL DISORDERS; CHILDRENS-COMMUNICATION-CHECKLIST;
   AUTISM SPECTRUM DISORDER; LANGUAGE IMPAIRMENT; SPEAKING CHILDREN;
   COGNITIVE-STYLE; PREVALENCE; DIAGNOSIS; SPEECH; SLI
AB Developmental disorders, such as autism spectrum disorder and specific language impairment, are biologically based disorders that currently rely on behaviorally defined criteria for diagnosis and treatment. Specific behaviors that are included in diagnostic frameworks and the point at which individual differences in behavior constitute abnormality are largely arbitrary decisions. Such decisions are therefore likely to be strongly influenced by cultural values and expectations. This is evident in the dramatically different prevalence rates of autism spectrum disorder across countries and across different ethnic groups within the same country. In this article, we critically evaluate the understanding of developmental disorders from a cultural perspective. We specifically consider the challenges of applying diagnostic methods across cultural contexts, the influence of cultural values and expectations on the identification and treatment of children with suspected disorders, and how cross-cultural studies can help to refine cognitive theories of disorder that have been derived exclusively from Western North American and European investigations. Our review synthesizes clinical, cultural, and theoretical work in this area, highlighting potential universals of disorder and concluding with recommendations for future research and practice.
C1 [Norbury, Courtenay Frazier] Univ London, Dept Psychol, Egham TW20 0EX, Surrey, England.
   [Sparks, Alison] Amherst Coll, Dept Psychol, Amherst, MA 01002 USA.
RP Norbury, CF (reprint author), Univ London, Dept Psychol, Egham TW20 0EX, Surrey, England.
EM courtenay.norbury@rhul.ac.uk
CR Adams C, 2002, J CHILD PSYCHOL PSYC, V43, P973, DOI 10.1111/1469-7610.00226
   Akhtar N, 2008, CHILD DEV PERSPECT, V2, P59, DOI 10.1111/j.1750-8606.2008.00044.x
   Al-Farsi YM, 2011, J AUTISM DEV DISORD, V41, P821, DOI 10.1007/s10803-010-1094-8
   Al-Qabandi M, 2011, PEDIATRICS, V128, pE211, DOI 10.1542/peds.2010-1881
   American Psychiatric Association, 2011, DSM 5 DEV NEUR DIS
   American Speech-Language-Hearing Association, DEM PROF ASHA MEMB P
   Ametepee L., 2009, J INT ASS SPECIAL ED, V10, P11
   Autism and Developmental Disabilities Monitoring Network 2006 Principal Investigators, 2009, MORBIDITY MORTALITY, V58
   Autism Speaks, 2011, NEW STUD REV AUT PRE
   Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
   Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
   Bedore LM, 2005, APPL PSYCHOLINGUIST, V26, P195, DOI 10.1017/S0142716405050149
   Bernier R, 2010, CHILD ADOL PSYCH CL, V19, P855, DOI 10.1016/j.chc.2010.07.005
   Bishop D, 2009, ANN NY ACAD SCI, V1156, P1, DOI 10.1111/j.1749-6632.2009.04419.x
   Bishop D. V. M., 2003, CHILDRENS COMMUNICAT
   Bishop DVM, 2008, GENES BRAIN BEHAV, V7, P365, DOI 10.1111/j.1601-183X.2007.00360.x
   Blais C, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003022
   Bortolini U, 1997, J SPEECH LANG HEAR R, V40, P809
   Botting N, 1997, EUR J DISORDER COMM, V32, P317
   BRUNER J, 1990, HUM DEV, V33, P344
   Campbell T, 1997, J SPEECH LANG HEAR R, V40, P519
   Cappiello Matthew M, 2009, Pediatr Clin North Am, V56, P1501, DOI 10.1016/j.pcl.2009.09.017
   Carter JA, 2005, INT J LANG COMM DIS, V40, P385, DOI 10.1080/13682820500057301
   CASELLI MC, 1995, COGNITIVE DEV, V10, P159, DOI 10.1016/0885-2014(95)90008-X
   Constantino JN, 2011, PEDIATR RES, V69, p55R, DOI 10.1203/PDR.0b013e318212ec6e
   Davidoff J, 2008, COGNITION, V108, P702, DOI 10.1016/j.cognition.2008.06.004
   Davidovitch M, 2001, ISRAEL MED ASSOC J, V3, P188
   de Villiers Peter, 2004, Seminars in Speech and Language, V25, P57
   De Giacomo A, 1998, EUR CHILD ADOLES PSY, V7, P131
   Dyches TT, 2004, J AUTISM DEV DISORD, V34, P211, DOI 10.1023/B:JADD.0000022611.80478.73
   Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005
   Fisher SE, 2006, COGNITION, V101, P270, DOI 10.1016/j.cognition.2006.04.004
   Fombonne E, 1997, J AM ACAD CHILD PSY, V36, P1561, DOI 10.1016/S0890-8567(09)66566-7
   Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557
   Fombonne E, 2006, PEDIATRICS, V118, pE139, DOI 10.1542/peds.2005-2993
   Frith U., 2003, AUTISM EXPLAINING EN
   Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P1437, DOI 10.1111/j.1469-7610.2004.00326.x
   Gillberg C, 2006, J AUTISM DEV DISORD, V36, P429, DOI 10.1007/s10803-006-0081-6
   Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2
   Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0
   Helland WA, 2009, SCAND J PSYCHOL, V50, P287, DOI 10.1111/j.1467-9450.2009.00718.x
   Henrich J, 2010, BEHAV BRAIN SCI, V33, P61, DOI 10.1017/S0140525X0999152X
   Hirsh-Pasek K., 2005, SOCIAL POLICY REPORT, V19, P3
   Jaarsma P, 2012, HEALTH CARE ANAL, V20, P20, DOI 10.1007/s10728-011-0169-9
   Kawamura Y, 2008, PSYCHIAT CLIN NEUROS, V62, P152, DOI 10.1111/j.1440-1819.2008.01748.x
   Kelly DJ, 2011, DEVELOPMENTAL SCI, V14, P1176, DOI 10.1111/j.1467-7687.2011.01067.x
   Ketelaars MP, 2009, RES DEV DISABIL, V30, P952, DOI 10.1016/j.ridd.2009.01.006
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202
   Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522
   Lauber C, 2007, INT REV PSYCHIATR, V19, P157, DOI 10.1080/09540260701278903
   Leonard L., 2009, HDB CHILD LANGUAGE D, P308
   Leonard L. B., 1998, CHILDREN SPECIFIC LA
   Liu D, 2008, DEV PSYCHOL, V44, P523, DOI 10.1037/0012-1649.44.2.523
   Liu SY, 2011, J EXP CHILD PSYCHOL, V108, P180, DOI 10.1016/j.jecp.2010.06.008
   Lord C., 1999, AUTISM DIAGNOSTIC OB
   Lord C, 2010, SOCIAL POLICY REPORT, V24, P1
   Madsen KM, 2002, NEW ENGL J MED, V347, P1477, DOI 10.1056/NEJMoa021134
   Magnusson P, 2001, J AUTISM DEV DISORD, V31, P153, DOI 10.1023/A:1010795014548
   Mandell DS, 2002, J AM ACAD CHILD PSY, V41, P1447, DOI 10.1097/01.CHI.0000024863.60748.53
   Mandell DS, 2007, J AUTISM DEV DISORD, V37, P1795, DOI 10.1007/s10803-006-0314-8
   Matsui T, 2009, DEVELOPMENTAL SCI, V12, P602, DOI 10.1111/j.1467-7687.2008.00812.x
   Mbise A. S., 1990, PRACTICAL APPROACHES, P225
   Nadig A, 2010, NEUROPSYCHOLOGIA, V48, P2730, DOI 10.1016/j.neuropsychologia.2010.05.020
   Nelson HD, 2006, PEDIATRICS, V117, pE298, DOI 10.1154/peds.2005-1467
   Nisbett RE, 2003, P NATL ACAD SCI USA, V100, P11163, DOI 10.1073/pnas.1934527100
   Norbury CF, 2004, INT J LANG COMM DIS, V39, P345, DOI 10.1080/13682820410001654883
   Norbury CF, 2009, J CHILD PSYCHOL PSYC, V50, P834, DOI 10.1111/j.1469-7610.2009.02073.x
   OETTING JB, 1993, J SPEECH HEAR RES, V36, P1236
   Palmer RF, 2010, AM J PUBLIC HEALTH, V100, P270, DOI 10.2105/AJPH.2008.150565
   PARNER ET, 2011, AUTISM, V41, P1601, DOI DOI 10.1007/S10803-011-1186-0
   Paula CS, 2011, J AUTISM DEV DISORD, V41, P1738, DOI 10.1007/s10803-011-1200-6
   Pearson Barbara Zurer, 2004, Seminars in Speech and Language, V25, P13
   Pellicano E, 2011, AUTISM RES, V4, P271, DOI 10.1002/aur.201
   Pena ED, 1997, LANG SPEECH HEAR SER, V28, P323
   Redmond SM, 2002, J SPEECH LANG HEAR R, V45, P190, DOI 10.1044/1092-4388(2002/014)
   Rescorla L, 2009, J SPEECH LANG HEAR R, V52, P16, DOI 10.1044/1092-4388(2008/07-0171)
   Rice ML, 1998, J SPEECH LANG HEAR R, V41, P1412
   RICE ML, 1993, J SPEECH HEAR RES, V36, P1249
   Rice ML, 2004, J SPEECH LANG HEAR R, V47, P816, DOI 10.1044/1092-4388(2004/061)
   Rollins PR, 1998, J CHILD LANG, V25, P653
   Royal College of Speech and Language Therapists, 2002, DEV DIV STRAT
   Rutter M, 2011, J CHILD PSYCHOL PSYC, V52, P647, DOI 10.1111/j.1469-7610.2011.02367.x
   Rutter M., 2003, AUTISM DIAGNOSTIC IN
   Saxe G. B., 1988, EDUC RES, V17, P14, DOI DOI 10.3102/0013189X017006014
   SCHIEFFELIN BB, 1986, ANNU REV ANTHROPOL, V15, P163, DOI 10.1146/annurev.an.15.100186.001115
   Schultz R., 2002, ARCH GEN PSYCHIAT, V59, P809
   Seymour H. N., 2005, DIAGNOSTIC EVALUATIO
   Seymour Harry N, 2004, Semin Speech Lang, V25, P27
   Seymour Harry N, 2004, Semin Speech Lang, V25, P3
   Silva M. J., 1996, CHAMELEON READERS TE
   Sparks A, 2008, SPANISH-LANGUAGE NARRATION AND LITERACY: CULTURE, COGNITION, AND EMOTION, P273
   Stein DJ, 2010, PSYCHOL MED, V40, P1759, DOI 10.1017/S0033291709992261
   STEINHAUSEN HC, 1986, J AM ACAD CHILD PSY, V25, P186, DOI 10.1016/S0002-7138(09)60225-9
   Sun X, 2010, RES AUTISM SPECT DIS, V4, P156, DOI 10.1016/j.rasd.2009.10.003
   Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, V1, P335
   Tager-Flusberg H, 2003, PHILOS T ROY SOC B, V358, P303, DOI 10.1098/rstb.2002.1198
   Tomblin J. B., 2008, UNDERSTANDING DEV LA, P93
   Tomblin J. B., 2011, INT J LANG COMM DIS, V46, P127, DOI [DOI 10.1111/J.1460-6984.2011.00017.X, 10.1111/j.1460-6984.2011.00017.x]
   Tomblin J. B., 2006, LEARNING DISABILITIE, V21, P8, DOI DOI 10.1111/J.1540-5826.2006.CI0203.X
   Tomblin JB, 1997, J SPEECH LANG HEAR R, V40, P1245
   Ullman MT, 2005, CORTEX, V41, P399, DOI 10.1016/S0010-9452(08)70276-4
   van Kleeck A, 1994, AM J SPEECH-LANG PAT, V3, P67
   van der Lely HKJ, 2005, TRENDS COGN SCI, V9, P53, DOI 10.1016/j.tics.2004.12.002
   World Health Organization (WHO), 2002, COMM LANG FUNCT DIS
   Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x
   Zhang J., 2006, INT J SPECIAL ED, V21, P109
   Zhang XY, 2000, AM J SPEECH-LANG PAT, V9, P345
NR 108
TC 13
Z9 13
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0012-1649
J9 DEV PSYCHOL
JI Dev. Psychol.
PD JAN
PY 2013
VL 49
IS 1
BP 45
EP 58
DI 10.1037/a0027446
PG 14
WC Psychology, Developmental
SC Psychology
GA 069YC
UT WOS:000313472000005
PM 22390668
ER

PT J
AU Kapp, SK
   Gillespie-Lynch, K
   Sherman, LE
   Hutman, T
AF Kapp, Steven K.
   Gillespie-Lynch, Kristen
   Sherman, Lauren E.
   Hutman, Ted
TI Deficit, Difference, or Both? Autism and Neurodiversity
SO DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
DE autism; neurodiversity; parenting; adaptation; identity
ID SPECTRUM DISORDER; ASPERGER-SYNDROME; FUNCTIONING AUTISM; DIAGNOSIS;
   COMMUNITY; ASSOCIATIONS; DISABILITY; CHILDREN; PARENTS; ADULTS
AB The neurodiversity movement challenges the medical model's interest in causation and cure, celebrating autism as an inseparable aspect of identity. Using an online survey, we examined the perceived opposition between the medical model and the neurodiversity movement by assessing conceptions of autism and neurodiversity among people with different relations to autism. Participants (N = 657) included autistic people, relatives and friends of autistic people, and people with no specified relation to autism. Self-identification as autistic and neurodiversity awareness were associated with viewing autism as a positive identity that needs no cure, suggesting core differences between the medical model and the neurodiversity movement. Nevertheless, results suggested substantial overlap between these approaches to autism. Recognition of the negative aspects of autism and endorsement of parenting practices that celebrate and ameliorate but do not eliminate autism did not differ based on relation to autism or awareness of neurodiversity. These findings suggest a deficit-as-difference conception of autism wherein neurological conditions may represent equally valid pathways within human diversity. Potential areas of common ground in research and practice regarding autism are discussed.
C1 [Kapp, Steven K.] Univ Calif Los Angeles, Grad Sch Educ & Informat Studies, Los Angeles, CA 90095 USA.
   [Gillespie-Lynch, Kristen; Sherman, Lauren E.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
   [Hutman, Ted] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
RP Kapp, SK (reprint author), Univ Calif Los Angeles, Grad Sch Educ & Informat Studies, 3132 Moore Hall,Box 951521, Los Angeles, CA 90095 USA.
EM kapp@ucla.edu; proserpinae@ucla.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Anckarsater H, 2010, INT J LAW PSYCHIAT, V33, P59, DOI 10.1016/j.ijlp.2009.12.001
   Armstrong T., 2010, NEURODIVERSITY DISCO
   Bagatell N, 2010, ETHOS, V38, P33, DOI 10.1111/j.1548-1352.2009.01080.x
   Baker D. L., 2011, POLITICS NEURODIVERS
   Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471
   Beauchamp-Pryor K, 2011, DISABIL SOC, V26, P5, DOI 10.1080/09687599.2011.529662
   Benford P., 2009, J ASSISTIVE TECHNOLO, V3, P44, DOI DOI 10.1108/17549450200900015
   Brownlow C, 2010, J INTELLECT DEV DIS, V35, P14, DOI 10.3109/13668250903496336
   Brugha TS, 2011, ARCH GEN PSYCHIAT, V68, P459, DOI 10.1001/archgenpsychiatry.2011.38
   Callahan K, 2010, J AUTISM DEV DISORD, V40, P74, DOI 10.1007/s10803-009-0834-0
   Cappe E, 2011, QUAL LIFE RES, V20, P1279, DOI 10.1007/s11136-011-9861-3
   Chamak B, 2008, SOCIOL HEALTH ILL, V30, P76, DOI 10.1111/j.1467-9566.2007.01053.x
   Clarke J, 2008, SOC WORK HEALTH CARE, V46, P85, DOI 10.1300/J010v46n03_05
   Di Pietro N. C., NEUROETHICS IN PRESS
   Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
   Giles DC, 2011, QUAL HEALTH RES, V21, P419, DOI 10.1177/1049732310381388
   Gilmour L, 2012, RES AUTISM SPECT DIS, V6, P313, DOI 10.1016/j.rasd.2011.06.003
   Griffin E, 2009, DYSLEXIA, V15, P23, DOI 10.1002/dys.383
   Griffith G. M., AUTISM IN PRESS
   Hahn HD, 2004, J HEALTH SOC BEHAV, V45, P453
   Hall Heather R, 2012, Issues Compr Pediatr Nurs, V35, P24, DOI 10.3109/01460862.2012.646479
   Hebert Elizabeth Baltus, 2010, Issues Compr Pediatr Nurs, V33, P149, DOI 10.3109/01460862.2010.498331
   Hinshaw SP, 2008, ANNU REV CLIN PSYCHO, V4, P367, DOI 10.1146/annurev.clinpsy.4.022007.141245
   Humphrey N, 2008, AUTISM, V12, P23, DOI 10.1177/1362361307085267
   Hutman T, 2009, J CHILD PSYCHOL PSYC, V50, P1255, DOI 10.1111/j.1469-7610.2009.02109.x
   Huws JC, 2010, DISABIL SOC, V25, P331, DOI 10.1080/09687591003701231
   Huws JC, 2008, J INTELLECT DEV DIS, V33, P99, DOI 10.1080/13668250802010394
   Jaarsma P, 2012, HEALTH CARE ANAL, V20, P20, DOI 10.1007/s10728-011-0169-9
   Jack J., 2011, DISABILITY STUDIES Q, V31
   Jones R. S. P., 2001, J LEARNING DISABILIT, V5, P35, DOI DOI 10.1177/146900470100500104
   Jordan CJ, 2010, INTELLECT DEV DISAB, V48, P220, DOI 10.1352/1934-9556-48.3.220
   Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532
   King G, 2003, QUAL HEALTH RES, V13, P184, DOI 10.1177/1049732302239598
   Krahn TM, 2012, J BIOETHIC INQ, V9, P93, DOI 10.1007/s11673-011-9350-y
   Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835
   Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a
   Langan M, 2011, DISABIL SOC, V26, P193, DOI 10.1080/09687599.2011.544059
   Leckman JF, 2011, J CHILD PSYCHOL PSYC, V52, P333, DOI 10.1111/j.1469-7610.2011.02378.x
   Madeo AC, 2011, AM J MED GENET A, V155A, P1777, DOI 10.1002/ajmg.a.34054
   Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004
   Meadan H, 2010, EXCEPT CHILDREN, V77, P7
   Mesibov G., 2004, TEACCH APPROACH AUTI
   Milshtein S, 2010, J AUTISM DEV DISORD, V40, P89, DOI 10.1007/s10803-009-0837-x
   Ne'eman A., 2010, DISABILITY STUDIES Q, V30
   Nicolaidis C, 2011, PROG COMM HLTH PARTN, V5, P143, DOI 10.1353/cpr.2011.0022
   Oppenheim D, 2009, CHILD DEV, V80, P519, DOI 10.1111/j.1467-8624.2009.01276.x
   Orsini M., 2010, CRITICAL POLICY STUD, V4, P38, DOI DOI 10.1080/19460171003714989
   Ortega F, 2009, BIOSOCIETIES, V4, P425, DOI 10.1017/S1745855209990287
   Palmer M., HLTH POLICY IN PRESS
   Pellicano E, 2011, AUTISM RES, V4, P271, DOI 10.1002/aur.201
   Portway SM, 2005, HEALTH RISK SOC, V7, P73, DOI 10.1080/09500830500042086
   Punshon C, 2009, AUTISM, V13, P265, DOI 10.1177/1362361309103795
   Reichow B., J AUTISM DE IN PRESS
   Robertson SM, 2010, DISABILITY STUDIES Q, V30
   Calzada LR, 2012, J AUTISM DEV DISORD, V42, P230, DOI 10.1007/s10803-011-1238-5
   Russell G., CLIN CHILD IN PRESS
   Russell G, 2010, CHILD CARE HLTH DEV, V36, P431, DOI 10.1111/j.1365-2214.2009.00994.x
   Samios C, 2008, RES AUTISM SPECT DIS, V2, P516, DOI 10.1016/j.rasd.2007.10.003
   Savarese E.T., 2010, DISABILITY STUDIES Q, V30
   Savarese R., 2010, DISABILITY STUDIES Q, V30
   Silverman C, 2012, UNDERSTANDING AUTISM: PARENTS, DOCTORS, AND THE HISTORY OF A DISORDER, P1
   Singh J, 2009, J AUTISM DEV DISORD, V39, P788, DOI 10.1007/s10803-008-0685-0
   Steiner AM, 2011, J POSIT BEHAV INTERV, V13, P178, DOI 10.1177/1098300710384134
   Stephenson J, 2012, RES AUTISM SPECT DIS, V6, P11, DOI 10.1016/j.rasd.2011.08.002
   Tincani M, 2009, RES PRACT PERS SEV D, V34, P81
   Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x
   Vismara LA, 2010, ANNU REV CLIN PSYCHO, V6, P447, DOI 10.1146/annurev.clinpsy.121208.131151
   Wachtel K, 2008, AUTISM, V12, P575, DOI 10.1177/1362361308094505
   White SW, 2011, AUTISM, V15, P683, DOI 10.1177/1362361310393363
   Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7
NR 71
TC 14
Z9 14
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0012-1649
EI 1939-0599
J9 DEV PSYCHOL
JI Dev. Psychol.
PD JAN
PY 2013
VL 49
IS 1
BP 59
EP 71
DI 10.1037/a0028353
PG 13
WC Psychology, Developmental
SC Psychology
GA 069YC
UT WOS:000313472000006
PM 22545843
ER

PT J
AU Rosenthal, M
   Wallace, GL
   Lawson, R
   Wills, MC
   Dixon, E
   Yerys, BE
   Kenworthy, L
AF Rosenthal, Michael
   Wallace, Gregory L.
   Lawson, Rachel
   Wills, Meagan C.
   Dixon, Eunice
   Yerys, Benjamin E.
   Kenworthy, Lauren
TI Impairments in Real-World Executive Function Increase From Childhood to
   Adolescence in Autism Spectrum Disorders
SO NEUROPSYCHOLOGY
LA English
DT Article
DE autism; executive function; BRIEF; development; age-related
ID DIAGNOSTIC INTERVIEW; CHILDREN; DEFICITS; PERFORMANCE; SYMPTOMS;
   VERSION; SKILLS
AB Objective: Although several studies have investigated developmental trajectories of executive functioning (EF) in individuals with autism spectrum disorders (ASD) using lab-based tasks, no study to date has directly measured how EF skills in everyday settings vary at different ages. The current study seeks to extend prior work by evaluating age-related differences in parent-reported EF problems during childhood and adolescence in a large cross-sectional cohort of children with ASD. Method: Children (N = 185) with an ASD without intellectual disability participated in the study. Participants were divided into four groups based on age (5-7, 8-10, 11-13, and 14-18-year-olds). The four age groups did not differ in IQ, sex ratio, or autism symptoms. Results: There were significant age effects (i.e., worsening scores with increasing age) in three of G. A. Gioia, P. K. Isquith, S. Guy, and L. Kenworthy's (2000) BRIEF: Behavior Rating Inventory of Executive Function, Odessa, FL, Psychological Assessment Resources scale scores: Initiate (p = .007), working memory (p = .003), and organization of materials (p = .023). In addition, analysis of the BRIEF scale profile revealed that, although multiple scales were elevated, the shift scale showed the greatest problems in both the youngest and oldest age cohorts. Conclusions: Older children with ASD show greater EF problems compared with the normative sample than younger children with ASD. Specifically, there is a widening divergence from the normative sample in metacognitive executive abilities in children with ASD as they age. This, in combination with significant, albeit more stable, impairments in flexibility, has implications for the challenges faced by high-functioning individuals with ASD as they attempt to enter mainstream work and social environments.
C1 [Rosenthal, Michael; Wills, Meagan C.; Yerys, Benjamin E.; Kenworthy, Lauren] Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, Rockville, MD 20850 USA.
   [Wallace, Gregory L.; Dixon, Eunice] NIMH, Lab Brain & Cognit, US Dept HHS, NIH, Bethesda, MD USA.
   [Yerys, Benjamin E.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
RP Rosenthal, M (reprint author), Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, 15245 Shady Grove Rd,Suite 350, Rockville, MD 20850 USA.
EM MRosenthal01@gmail.com
FU Intramural Research Program of the United States Department of Health
   and Human Services; National Institutes of Health, National Institute of
   Mental Health (NIMH); NIMH [5K23MH86111]; Isadore and Bertha Gudelsky
   Foundation
FX We thank the families of the participants and the diagnostic team that
   characterized the participants for their efforts over the years. This
   research was supported by the Intramural Research Program of the United
   States Department of Health and Human Services, National Institutes of
   Health, National Institute of Mental Health (NIMH). B.E. Yerys was
   supported by the NIMH Grant 5K23MH86111. L. Kenworthy was supported by
   the Isadore and Bertha Gudelsky Foundation.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
   Best JR, 2010, CHILD DEV, V81, P1641, DOI 10.1111/j.1467-8624.2010.01499.x
   Conklin HM, 2007, DEV NEUROPSYCHOL, V31, P103, DOI 10.1207/s15326942dn3101_6
   Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101
   Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
   GERSTADT CL, 1994, COGNITION, V53, P129, DOI 10.1016/0010-0277(94)90068-X
   Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x
   Gilotty L, 2002, CHILD NEUROPSYCHOL, V8, P241, DOI 10.1076/chin.8.4.241.13504
   Gioia G. A., 2000, BRIEF BEHAV RATING I, DOI [10.1076/chin.8.4.249.13513, DOI 10.1076/CHIN.8.4.249.13513]
   Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004
   Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003
   Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010
   Huizinga M, 2011, CHILD NEUROPSYCHOL, V17, P51, DOI 10.1080/09297049.2010.509715
   Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7
   Kenworthy L, 2009, CHILD NEUROPSYCHOL, V15, P425, DOI 10.1080/09297040802646983
   Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465
   LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363
   Lopez BR, 2005, J AUTISM DEV DISORD, V35, P445, DOI 10.1007/s10803-005-5035-x
   LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030
   O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527
   OZONOFF S, 1994, DEV PSYCHOPATHOL, V6, P415, DOI 10.1017/S0954579400006027
   Pellicano E, 2010, CHILD DEV, V81, P1400, DOI 10.1111/j.1467-8624.2010.01481.x
   Psychological Assessment Resources, 2003, COMP WISC CARD SORT
   Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279
   Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd
   Wechsler D., 2004, WECHSLER INTELLIGENC
   Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd
   Yerys BE, 2009, AUTISM, V13, P523, DOI 10.1177/1362361309335716
   Yerys BE, 2007, J AUTISM DEV DISORD, V37, P1068, DOI 10.1007/s10803-006-0250-7
NR 33
TC 21
Z9 21
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD JAN
PY 2013
VL 27
IS 1
BP 13
EP 18
DI 10.1037/a0031299
PG 6
WC Psychology, Clinical; Neurosciences; Psychology
SC Psychology; Neurosciences & Neurology
GA 073QI
UT WOS:000313757200002
PM 23356593
ER

PT J
AU Wojcik, DZ
   Moulin, CJA
   Souchay, C
AF Wojcik, Dominika Z.
   Moulin, Chris J. A.
   Souchay, Celine
TI Metamemory in Children With Autism: Exploring "Feeling-of-Knowing" in
   Episodic and Semantic Memory
SO NEUROPSYCHOLOGY
LA English
DT Article
DE autism; memory; metamemory; feeling-of-knowing
ID MEDIAL TEMPORAL-LOBE; SPECTRUM DISORDER; AUTOBIOGRAPHICAL MEMORY;
   ASPERGERS-SYNDROME; AUTONOETIC CONSCIOUSNESS; RECOGNITION MEMORY;
   ALZHEIMERS-DISEASE; OLDER-ADULTS; RECALL; JUDGMENTS
AB Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder primarily affecting social function and communication. Recently, there has been an interest in whether people with ASD also show memory deficits. Studies in ASD have revealed subtle impairments on tasks requiring participants to learn new information (episodic memory), but intact performance on general knowledge tasks (semantic memory). The novelty of this study was to explore metamemory (i.e., awareness of memory performance) and to examine whether children with ASD suffer from a generalized metamemory deficit common to all forms of memory, or would only present deficits on episodic metamemory tasks. Method: To assess metamemory functioning we administered 2 feeling-of-knowing (FOK) tasks, 1 for episodic and 1 for semantic materials. In these tasks, participants are asked to predict the likelihood of subsequently recognizing currently unrecalled information. Results: It was found that children with autism made inaccurate FOK predictions, but only for episodic materials. Conclusion: A specific deficit in meta-cognition emerges for only one set of materials. We argue that this deficit can be conceived of as reflecting a deficit in recollection, stemming from an inability to cast the self in the past and retrieve information about the study episode.
C1 [Wojcik, Dominika Z.] Univ Leeds, Inst Psychol Sci, Leeds, W Yorkshire, England.
   [Souchay, Celine] Univ Bourgogne, Pole AAFE, LEAD CNRS, UMR 5022, F-21065 Dijon, France.
RP Souchay, C (reprint author), Univ Bourgogne, Pole AAFE, LEAD CNRS, UMR 5022, BP 26513, F-21065 Dijon, France.
EM celine.souchay@me.com
CR [Anonymous], 1991, BMJ, V302, P1194
   BLAKE M, 1973, J VERB LEARN VERB BE, V12, P311, DOI 10.1016/S0022-5371(73)80075-1
   BOUCHER J, 1976, BRIT J PSYCHOL, V67, P73
   Boucher J., 2012, AUTISM, P1
   Boucher Jill, 2005, Cogn Neuropsychiatry, V10, P165, DOI 10.1080/13546800444000038
   Boucher J, 2012, PSYCHOL BULL, V138, P458, DOI 10.1037/a0026869
   Bowler DM, 2007, CONSCIOUS COGN, V16, P124, DOI 10.1016/j.concog.2005.12.001
   Bowler DM, 2004, J AUTISM DEV DISORD, V34, P533, DOI 10.1007/s10803-004-2548-7
   Bowler DM, 1997, NEUROPSYCHOLOGIA, V35, P65, DOI 10.1016/S0028-3932(96)00054-1
   Bowler DM, 2000, J AUTISM DEV DISORD, V30, P295, DOI 10.1023/A:1005575216176
   Bowler DM, 2000, J ABNORM PSYCHOL, V109, P663, DOI 10.1037//0021-843X.109.4.663
   Brendgen M, 2004, J ABNORM CHILD PSYCH, V32, P305, DOI 10.1023/B:JACP.0000026144.08470.cd
   BROWN R, 1966, J VERB LEARN VERB BE, V5, P325, DOI 10.1016/S0022-5371(66)80040-3
   Bruck M, 2007, DEV PSYCHOPATHOL, V19, P73, DOI 10.1017/S0954579407070058
   Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011
   BUTTERFIELD EC, 1988, DEV PSYCHOL, V24, P654, DOI 10.1037/0012-1649.24.5.654
   Clare L, 2000, J CLIN EXP NEUROPSYC, V22, P132, DOI 10.1076/1380-3395(200002)22:1;1-8;FT132
   COLTHEART M, 1981, Q J EXP PSYCHOL-A, V33, P497
   Conway M. A., 2006, SCI MEMORY CONCEPTS, P237
   Crane L, 2008, J AUTISM DEV DISORD, V38, P498, DOI 10.1007/s10803-007-0420-2
   CULTICE JC, 1983, CHILD DEV, V54, P1480, DOI 10.1111/j.1467-8624.1983.tb00063.x
   Dunn D. M., 2007, PEABODY PICTURE VOCA
   Eichenbaum H, 2007, ANNU REV NEUROSCI, V30, P123, DOI 10.1146/annurev.neuro.30.051606.094328
   EYSENCK MW, 1979, BRIT J PSYCHOL, V70, P243
   Farrant A, 1999, J AUTISM DEV DISORD, V29, P359, DOI 10.1023/A:1023074726548
   Farrant A, 1999, CHILD DEV, V70, P107
   Farrant A, 1998, J AUTISM DEV DISORD, V28, P43, DOI 10.1023/A:1026010919219
   FLAVELL JH, 1971, HUM DEV, V14, P272
   FLAVELL JH, 1979, AM PSYCHOL, V34, P906, DOI 10.1037/0003-066X.34.10.906
   Gaigg SB, 2008, NEUROPSYCHOLOGIA, V46, P2336, DOI 10.1016/j.neuropsychologia.2008.03.008
   Ghetti S, 2002, DEV PSYCHOL, V38, P705, DOI 10.1037//0012.1649.38.5.705
   Goddard L, 2007, J AUTISM DEV DISORD, V37, P291, DOI 10.1007/s10803-006-0168-0
   GOODMAN LA, 1954, J AM STAT ASSOC, V49, P732, DOI 10.2307/2281536
   Habib R, 2003, TRENDS COGN SCI, V7, P241, DOI 10.1016/S1364-6613(03)00110-4
   Hala S, 2005, J AUTISM DEV DISORD, V35, P75, DOI 10.1007/s10803-004-1036-4
   Hare DJ, 2007, RES DEV DISABIL, V28, P317, DOI 10.1016/j.ridd.2006.03.003
   HART JT, 1965, J EDUC PSYCHOL, V56, P208, DOI 10.1037/h0022263
   Hicks JL, 2002, MEM COGNITION, V30, P60, DOI 10.3758/BF03195265
   Hill EL, 2002, INFANT CHILD DEV, V11, P159, DOI 10.1002/icd.303
   JANOWSKY JS, 1989, PSYCHOBIOLOGY, V17, P3
   Jennings JM, 2003, NEUROPSYCHOL REHABIL, V13, P417, DOI 10.1080/09602010244000390
   JOHNSON MK, 1993, PSYCHOL BULL, V114, P3, DOI 10.1037//0033-2909.114.1.3
   Jordan R., 1993, EDUC PSYCHOL, V13, P359, DOI 10.1080/0144341930130312
   Kelley CM, 2003, J MEM LANG, V48, P704, DOI 10.1016/S0749-596X(02)00504-1
   Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103
   Kikyo H, 2002, NEURON, V36, P177, DOI 10.1016/S0896-6273(02)00939-X
   Kikyo H, 2004, NEUROIMAGE, V23, P1348, DOI 10.1016/j.neuroimage.2004.08.013
   Kinjo H, 2010, INT J AGING HUM DEV, V71, P185, DOI 10.2190/AG.71.3.b
   KORIAT A, 1993, PSYCHOL REV, V100, P609, DOI 10.1037/0033-295X.100.4.609
   Koriat A, 2003, J EXP PSYCHOL LEARN, V29, P1095, DOI 10.1037/0278-7393.29.6.1095
   Lind S, 2010, AUTISM, V14, P1
   Lind SE, 2009, J AUTISM DEV DISORD, V39, P643, DOI 10.1007/s10803-008-0670-7
   Lombardo MV, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000883
   Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
   Maril A, 2003, NEUROIMAGE, V18, P827, DOI 10.1016/S1063-8119(03)00014-4
   METCALFE J, 1993, J EXP PSYCHOL LEARN, V19, P851, DOI 10.1037//0278-7393.19.4.851
   Metcalfe J., 2000, OXFORD HDB MEMORY, P197
   Millward C, 2000, J AUTISM DEV DISORD, V30, P15, DOI 10.1023/A:1005455926727
   Nelson T. O., 1990, PSYCHOL LEARN MOTIV, V26, P125, DOI [10.1016/S0079-7421(08) 60053-5, DOI 10.1016/S0079-7421(08)60053-5]
   NELSON TO, 1991, PSYCHOL SCI, V2, P267, DOI 10.1111/j.1467-9280.1991.tb00147.x
   NELSON TO, 1984, PSYCHOL BULL, V95, P109, DOI 10.1037/0033-2909.95.1.109
   Pannu JK, 2005, NEUROPSYCHOL REV, V15, P105, DOI 10.1007/s11065-7091-6
   Pelphrey KA, 2011, J CHILD PSYCHOL PSYC, V52, P631, DOI 10.1111/j.1469-7610.2010.02349.x
   Roebers CM, 2007, BRIT J DEV PSYCHOL, V25, P109, DOI 10.1348/026151006X104392
   Russell J, 1999, Cogn Neuropsychiatry, V4, P303
   Russell J, 2001, J CHILD PSYCHOL PSYC, V42, P317, DOI 10.1017/S0021963001006874
   Sacher M, 2009, CONSCIOUS COGN, V18, P754, DOI 10.1016/j.concog.2009.04.001
   Salmond CH, 2005, EUR J NEUROSCI, V22, P764, DOI 10.1111/j.1460-9568.2005.04217.x
   SCHACTER DL, 1985, CAN J PSYCHOL, V39, P467, DOI 10.1037/h0080074
   Lockl K, 2002, INT J BEHAV DEV, V26, P327, DOI 10.1080/01650250143000210
   Schneider W, 1999, ATTENTION PERFORM, V17, P487
   Schnyer DM, 2005, J COGNITIVE NEUROSCI, V17, P832, DOI 10.1162/0898929053747694
   SCHRAW G, 1995, APPL COGNITIVE PSYCH, V9, P321, DOI 10.1002/acp.2350090405
   SNODGRASS JG, 1988, J EXP PSYCHOL GEN, V117, P34, DOI 10.1037//0096-3445.117.1.34
   Souchay C, 2000, NEUROPSYCHOLOGY, V14, P299, DOI 10.1037//0894-4105.14.2.299
   Souchay C, 2007, CORTEX, V43, P987, DOI 10.1016/S0010-9452(08)70696-8
   Souchay C, 2007, CONSCIOUS COGN, V16, P769, DOI 10.1016/j.concog.2006.11.002
   Souchay C, 2002, NEUROPSYCHOLOGIA, V40, P2386, DOI 10.1016/S0028-3932(02)00075-1
   Souchay C, 2009, CURR ALZHEIMER RES, V6, P186
   Tanweer T, 2010, NEUROPSYCHOLOGIA, V48, P900, DOI 10.1016/j.neuropsychologia.2009.11.007
   Thomas AK, 2011, J EXP PSYCHOL LEARN, V37, P96, DOI 10.1037/a0021612
   TULVING E, 1985, AM PSYCHOL, V40, P385, DOI 10.1037/0003-066X.40.4.385
   Wechsler D, 1999, WECHSLER ABBREVIATED
   Wheeler MA, 1997, PSYCHOL BULL, V121, P331, DOI 10.1037/0033-2909.121.3.331
   Wilkinson DA, 2010, J AUTISM DEV DISORD, V40, P1371, DOI 10.1007/s10803-010-0995-x
   Williams D, 2009, J AUTISM DEV DISORD, V39, P251, DOI 10.1007/s10803-008-0619-x
   Williams DM, 2009, J AUTISM DEV DISORD, V39, P865, DOI 10.1007/s10803-009-0695-6
   Wojcik DZ, 2011, MEMORY, V19, P549, DOI 10.1080/09658211.2011.590506
   Wright DB, 1996, APPL COGNITIVE PSYCH, V10, P261, DOI 10.1002/(SICI)1099-0720(199606)10:3<261::AID-ACP387>3.3.CO;2-S
   Yonelinas AP, 2002, J MEM LANG, V46, P441, DOI 10.1006/jmla.2002.2864
NR 90
TC 6
Z9 6
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD JAN
PY 2013
VL 27
IS 1
BP 19
EP 27
DI 10.1037/a0030526
PG 9
WC Psychology, Clinical; Neurosciences; Psychology
SC Psychology; Neurosciences & Neurology
GA 073QI
UT WOS:000313757200003
PM 23148497
ER

PT J
AU Eddy, CM
   Beck, SR
   Mitchell, IJ
   Praamstra, P
   Pall, HS
AF Eddy, Clare M.
   Beck, Sarah R.
   Mitchell, Ian J.
   Praamstra, Peter
   Pall, Hardev S.
TI Theory of Mind Deficits in Parkinson's Disease: A Product of Executive
   Dysfunction?
SO NEUROPSYCHOLOGY
LA English
DT Article
DE Parkinson's disease; executive function; theory of mind; working memory;
   basal ganglia
ID HIGH-FUNCTIONING AUTISM; TRAUMATIC BRAIN-INJURY; VERBAL WORKING-MEMORY;
   INHIBITORY CONTROL; COGNITIVE IMPAIRMENT; STORY COMPREHENSION; LOBE
   CONTRIBUTIONS; ASPERGER-SYNDROME; RECOGNITION; LANGUAGE
AB Objective: Patients with Parkinson's disease (PD) can perform poorly on tasks involving theory of mind (ToM): the ability to reason about mental states. We investigated whether patients' ToM deficits were independent of executive dysfunction. Method: Experiment 1 aimed to establish that ToM deficits were present, and 2 following experiments manipulated the working memory (WM) demands of the ToM task. Results: In Experiment 1, 15 patients with PD performed significantly more poorly than controls on a false belief vignette task but not on a faux pas task. Errors were related to poor verbal fluency. In Experiment 2, 24 patients with PD made fewer errors on shorter false belief vignettes than the original FBT, and errors on the latter were related to WM impairment. In Experiment 3, the FBT was presented as a comic strip visible throughout questioning, reducing WM demands. Patients (n = 24) made memory errors but no false belief errors on the comic strip. They exhibited no verbal fluency or WM impairments, but did exhibit deficits on a black-and-white Stroop task. False belief errors were not correlated with executive performance. Conclusions: PD patients made very few ToM errors that were independent of errors on memory questions, so in this sample, ToM deficits per se appear unlikely. However, patients still made errors on ToM tasks when associated incidental WM demands were considerably reduced, highlighting the need for future investigations of ToM in PD to account for the role of more general cognitive restrictions exhibited by even some medicated, early stage patients.
C1 [Eddy, Clare M.] Birmingham & Solihull Mental Hlth NHS Fdn Trust, Natl Ctr Mental Hlth, Dept Neuropsychiat, Birmingham B15 2FG, W Midlands, England.
   [Eddy, Clare M.; Pall, Hardev S.] Univ Birmingham, Coll Med & Dent Sci, Sch Clin & Expt Med, Birmingham, W Midlands, England.
   [Beck, Sarah R.; Mitchell, Ian J.] Univ Birmingham, Sch Psychol, Coll Life & Environm Sci, Birmingham B15 2TT, W Midlands, England.
   [Praamstra, Peter] Radboud Univ Nijmegen, Nijmegen Med Ctr, Dept Neurol, NL-6525 ED Nijmegen, Netherlands.
   [Pall, Hardev S.] Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Med Ctr, Dept Neurol, Birmingham, W Midlands, England.
RP Eddy, CM (reprint author), Birmingham & Solihull Mental Hlth NHS Fdn Trust, Natl Ctr Mental Hlth, Dept Neuropsychiat, 25 Vincent Dr, Birmingham B15 2FG, W Midlands, England.
EM clare.eddy@bsmhft.nhs.uk
RI Beck, Sarah/A-9530-2008
OI Beck, Sarah/0000-0001-6426-1603
CR Abu-Akel A, 2003, MED HYPOTHESES, V60, P382, DOI 10.1016/S0306-9877(02)00406-1
   Aleman A, 2008, NEUROPSYCHOBIOLOGY, V57, P44, DOI 10.1159/000129666
   Apperly IA, 2004, J COGNITIVE NEUROSCI, V16, P1773, DOI 10.1162/0898929042947928
   Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436
   Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
   Beck S. R., 2009, THINK REASONING, V15, P3337
   Berg E, 2003, CLIN LINGUIST PHONET, V17, P63, DOI 10.1080/0269920021000055540
   Berry EL, 1999, NEUROPSYCHOLOGIA, V37, P787, DOI 10.1016/S0028-3932(98)00137-7
   Bibby H, 2005, NEUROPSYCHOLOGIA, V43, P99, DOI 10.1016/j.neuropsychologia.2004.04.027
   Bodden ME, 2010, PARKINSONISM RELAT D, V16, P466, DOI 10.1016/j.parkreldis.2010.04.014
   Carlson SM, 2001, CHILD DEV, V72, P1032, DOI 10.1111/1467-8624.00333
   Carlson SM, 2002, INFANT CHILD DEV, V11, P73, DOI 10.1002/icd.298
   Channon S, 2005, BRAIN LANG, V93, P123, DOI 10.1016/j.bandl.2004.09.002
   COOPER JA, 1991, BRAIN, V114, P2095, DOI 10.1093/brain/114.5.2095
   CRONINGOLOMB A, 1994, NEUROPSYCHOLOGIA, V32, P579, DOI 10.1016/0028-3932(94)90146-5
   Eddy CM, 2010, COGN BEHAV NEUROL, V23, P178, DOI 10.1097/WNN.0b013e3181e61cb7
   Faglioni P, 1997, NEUROPSYCHOLOGIA, V35, P767, DOI 10.1016/S0028-3932(96)00125-X
   FLETCHER PC, 1995, COGNITION, V57, P109, DOI 10.1016/0010-0277(95)00692-R
   Flynn E, 2007, INFANT CHILD DEV, V16, P53, DOI 10.1002/icd.500
   Gabrieli JDE, 1996, NEUROPSYCHOLOGY, V10, P322, DOI 10.1037/0894-4105.10.3.321
   Gaillard WD, 2000, NEUROLOGY, V54, P180
   Gallagher HL, 2000, NEUROPSYCHOLOGIA, V38, P11, DOI 10.1016/S0028-3932(99)00053-6
   Gilbert B, 2005, NEUROPSYCHOLOGY, V19, P106, DOI 10.1037/0894-4105.19.1.106
   Gordon ACL, 1998, J EXP CHILD PSYCHOL, V68, P70, DOI 10.1006/jecp.1997.2423
   Gregory C, 2002, BRAIN, V125, P752, DOI 10.1093/brain/awf079
   Henry JD, 2006, NEUROPSYCHOLOGIA, V44, P1623, DOI 10.1016/j.neuropsychologia.2006.03.020
   HOEHN MM, 1967, NEUROLOGY, V17, P427
   Kawamura M, 2007, J NEUROL, V254, P49, DOI 10.1007/s00415-007-4008-8
   Knoke D, 1998, BRAIN COGNITION, V38, P261, DOI 10.1006/brcg.1998.1042
   LEES AJ, 1983, BRAIN, V106, P257, DOI 10.1093/brain/106.2.257
   McNamara P, 2003, J NEUROL NEUROSUR PS, V74, P1065, DOI 10.1136/jnnp.74.8.1065
   Mengelberg Alexia, 2003, Cogn Neuropsychiatry, V8, P191, DOI 10.1080/13546800244000292
   Mimura M, 2006, PARKINSONISM RELAT D, V12, P169, DOI 10.1016/j.parkreldis.2005.12.003
   Monetta L, 2009, CORTEX, V45, P972, DOI 10.1016/j.cortex.2009.02.021
   Monetta L, 2008, J NEUROLINGUIST, V21, P400, DOI 10.1016/j.jneuroling.2007.11.002
   Oeda R., 2003, THESIS U TOKYO TOKYO
   Peron J, 2009, NEUROPSYCHOLOGIA, V47, P406, DOI 10.1016/j.neuropsychologia.2008.09.008
   Riggs KJ, 1998, COGNITIVE DEV, V13, P73, DOI 10.1016/S0885-2014(98)90021-1
   SAGAR HJ, 1988, BRAIN, V111, P525, DOI 10.1093/brain/111.3.525
   Saltzman J, 2000, J INT NEUROPSYCH SOC, V6, P781, DOI 10.1017/S1355617700677056
   Samson D, 2005, BRAIN, V128, P1102, DOI 10.1093/brain/awh464
   Shamay-Tsoory SG, 2007, NEUROPSYCHOLOGIA, V45, P3054, DOI 10.1016/j.neuropsychologia.2007.05.021
   Shamay-Tsoory SG, 2007, SCHIZOPHR RES, V90, P274, DOI 10.1016/j.schres.2006.09.020
   Stone VE, 1998, J COGNITIVE NEUROSCI, V10, P640, DOI 10.1162/089892998562942
   Suzuki A, 2006, BRAIN, V129, P707, DOI 10.1093/brain/awl011
   Tsuruya N, 2011, PARKINSONISM RELAT D, V17, P246, DOI 10.1016/j.parkreldis.2010.09.001
   WATTS FN, 1988, BRIT J PSYCHOL, V79, P241
   Weintraub D, 2005, DEMENT GERIATR COGN, V20, P140, DOI 10.1159/000087043
   Werheid K, 2002, ARCH CLIN NEUROPSYCH, V17, P547, DOI 10.1016/S0887-6177(01)00134-2
   Yoshimura N, 2005, NEUROSCIENCE, V131, P523, DOI 10.1016/j.neuroscience.2004.09.054
   Zgaljardic DJ, 2006, J CLIN EXP NEUROPSYC, V28, P1127, DOI 10.1080/13803390500246910
NR 51
TC 4
Z9 4
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD JAN
PY 2013
VL 27
IS 1
BP 37
EP 47
DI 10.1037/a0031302
PG 11
WC Psychology, Clinical; Neurosciences; Psychology
SC Psychology; Neurosciences & Neurology
GA 073QI
UT WOS:000313757200005
PM 23356595
ER

EF