FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Levin, AR
Tager-Flusberg, H
Nelson, CA
AF Levin, A. R.
Tager-Flusberg, H.
Nelson, C. A.
TI Resting State Alpha Power Differences in Adults with Autism Spectrum
Disorders are not Present in Toddlers
SO ANNALS OF NEUROLOGY
LA English
DT Meeting Abstract
CT 42nd Annual Meeting of the Child-Neurology-Society
CY OCT 30-NOV 02, 2013
CL Austin, TX
SP Child Neurol Soc
DE Neuroimaging
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
SU 17
SI SI
BP S179
EP S179
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 264XL
UT WOS:000327914200529
ER
PT J
AU Lotta, LT
Conrad, K
Cory-Slechta, D
Schor, NF
AF Lotta, Louis T., Jr.
Conrad, Katherine
Cory-Slechta, Deborah
Schor, Nina F.
TI p75 Neurotrophin Receptor and Autism
SO ANNALS OF NEUROLOGY
LA English
DT Meeting Abstract
CT 42nd Annual Meeting of the Child-Neurology-Society
CY OCT 30-NOV 02, 2013
CL Austin, TX
SP Child Neurol Soc
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
SU 17
SI SI
BP S84
EP S84
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 264XL
UT WOS:000327914200290
ER
PT J
AU McEvoy, K
Jeste, SS
AF McEvoy, K.
Jeste, S. S.
TI High Frequency Oscillations Serve as a Promising Biomarker of Autism
Spectrum Disorders (ASD)
SO ANNALS OF NEUROLOGY
LA English
DT Meeting Abstract
CT 42nd Annual Meeting of the Child-Neurology-Society
CY OCT 30-NOV 02, 2013
CL Austin, TX
SP Child Neurol Soc
DE Neuroimaging
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
SU 17
SI SI
BP S179
EP S180
PG 2
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 264XL
UT WOS:000327914200530
ER
PT J
AU Mostofsky, S
D'Mello, A
Croceti, D
Stoodley, CJ
AF Mostofsky, S.
D'Mello, A.
Croceti, D.
Stoodley, C. J.
TI Cerebellar Grey Matter and Lobular Measures Correlate with Core Autism
Symptoms
SO ANNALS OF NEUROLOGY
LA English
DT Meeting Abstract
CT 42nd Annual Meeting of the Child-Neurology-Society
CY OCT 30-NOV 02, 2013
CL Austin, TX
SP Child Neurol Soc
DE Neuroimaging
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
SU 17
SI SI
BP S188
EP S189
PG 2
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 264XL
UT WOS:000327914200557
ER
PT J
AU Schor, NF
Lotta, LT
Conrad, K
Cor-Slechta, DA
AF Schor, N. F.
Lotta, L. T.
Conrad, K.
Cor-Slechta, D. A.
TI The p75 Neuurotrophin Receptor and Autism
SO ANNALS OF NEUROLOGY
LA English
DT Meeting Abstract
CT 42nd Annual Meeting of the Child-Neurology-Society
CY OCT 30-NOV 02, 2013
CL Austin, TX
SP Child Neurol Soc
DE Translational/experimental therapeutics
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
SU 17
SI SI
BP S129
EP S129
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 264XL
UT WOS:000327914200377
ER
PT J
AU Srivastava, S
Grados, MJ
AF Srivastava, S.
Grados, M. J.
TI Casemapper: A Computational Tool That Facilitates Phenotypic
Correlations in Autism Based on Case Studies from the Literature
SO ANNALS OF NEUROLOGY
LA English
DT Meeting Abstract
CT 42nd Annual Meeting of the Child-Neurology-Society
CY OCT 30-NOV 02, 2013
CL Austin, TX
SP Child Neurol Soc
DE Case studies/case series; Genetics
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
SU 17
SI SI
BP S147
EP S147
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 264XL
UT WOS:000327914200432
ER
PT J
AU Turkdogan, D
Eldemir, S
Ozyurt, O
Yarligan, T
Ocal, T
AF Turkdogan, D.
Eldemir, S.
Ozyurt, O.
Yarligan, T.
Ocal, T.
TI A Prevalence Study of Neurodevelopmental Delays and Autism
SO ANNALS OF NEUROLOGY
LA English
DT Meeting Abstract
CT 42nd Annual Meeting of the Child-Neurology-Society
CY OCT 30-NOV 02, 2013
CL Austin, TX
SP Child Neurol Soc
DE Case studies/case series
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
SU 17
SI SI
BP S138
EP S138
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 264XL
UT WOS:000327914200405
ER
PT J
AU Winkler-Schwartz, A
Garfinkle, J
Shevell, MI
AF Winkler-Schwartz, A.
Garfinkle, J.
Shevell, M., I
TI Autism Spectrum Disorder in a Term Birth NICU Population
SO ANNALS OF NEUROLOGY
LA English
DT Meeting Abstract
CT 42nd Annual Meeting of the Child-Neurology-Society
CY OCT 30-NOV 02, 2013
CL Austin, TX
SP Child Neurol Soc
DE Case studies/case series; Neonatal neurology
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
SU 17
SI SI
BP S150
EP S150
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 264XL
UT WOS:000327914200442
ER
PT J
AU Ferguson, BR
Gillis, JM
Sevlever, M
AF Ferguson, Bill R.
Gillis, Jennifer M.
Sevlever, Melina
TI A Brief Group Intervention Using Video Games to Teach Sportsmanship
Skills to Children With Autism Spectrum Disorders
SO CHILD & FAMILY BEHAVIOR THERAPY
LA English
DT Article
DE autism; Behavioral Skills Training; social skills intervention
ID HIGH-FUNCTIONING CHILDREN; SOCIAL-SKILLS; PREVENTION SKILLS;
ADOLESCENTS; BEHAVIOR; SPORTS
AB Impaired social skills represent a fundamental deficit for children with Autism Spectrum Disorders (ASD). Despite the potential importance of good sportsmanship, this social skill has received relatively little attention in the literature. The current study utilized a Behavioral Skills Training (BST) approach to teach three sportsmanship skills (i.e., complimenting, turn taking, and being a good sport) during video game play (Wii Sports). Six children with ASD completed this study. Findings suggest BST can be used effectively to teach sportsmanship skills to children with ASD. The use of video-game technology as part of social skills intervention programs is also discussed.
C1 [Ferguson, Bill R.; Gillis, Jennifer M.; Sevlever, Melina] Auburn Univ, Dept Psychol, Auburn, AL 36849 USA.
RP Ferguson, BR (reprint author), Auburn Univ, Dept Psychol, 226 Thach Hall, Auburn, AL 36849 USA.
EM fergubi@auburn.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
NR 23
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0731-7107
EI 1545-228X
J9 CHILD FAM BEHAV THER
JI Child Fam. Behav. Ther.
PD OCT 1
PY 2013
VL 35
IS 4
BP 293
EP 306
DI 10.1080/07317107.2013.846648
PG 14
WC Psychology, Clinical; Family Studies
SC Psychology; Family Studies
GA 268RO
UT WOS:000328188400002
ER
PT J
AU Macaulay, CE
Ford, RM
AF Macaulay, Catrin E.
Ford, Ruth M.
TI Family Influences on the Cognitive Development of Profoundly Deaf
Children: Exploring the Effects of Socioeconomic Status and Siblings
SO JOURNAL OF DEAF STUDIES AND DEAF EDUCATION
LA English
DT Article
ID EXECUTIVE FUNCTION; MIND DEVELOPMENT; INTELLECTUAL-DEVELOPMENT;
INDIVIDUAL-DIFFERENCES; FALSE BELIEF; LANGUAGE; MOTHERS; TALK; ABILITY;
AUTISM
AB We evaluated the cognitive development of 48 profoundly deaf children from hearing families (born 1994-2002, mean age M = 8.0 years at time of test, none of whom had received early auditory-verbal therapy) as a function of family socioeconomic status and number of siblings. Overall, the deaf children matched a younger group of 47 hearing controls (M = 4.6 years) on verbal ability, theory of mind, and cognitive inhibition. Partial correlations (controlling for age) revealed positive relations in the hearing group between maternal education and inhibition, between number of younger siblings and references to emotions, and between number of close-in-age siblings and references to desires and false beliefs. In the deaf group, there were positive relations between household income and memory span, between maternal education and references to false beliefs, and between number of younger siblings and nonverbal ability. In contrast, deaf children with a greater number of older siblings aged = 12 years showed inferior memory span, inhibition, belief understanding, picture-sequencing accuracy, and mental-state language, suggesting that they failed to compete successfully with older siblings for their parents' attention and material resources. We consider the implications of the findings for understanding birth-order effects on deaf and language-impaired children.
C1 [Macaulay, Catrin E.] Swansea Univ, Swansea SA21 8PP, W Glam, Wales.
[Ford, Ruth M.] Griffith Univ, Nathan, Qld 4111, Australia.
RP Macaulay, CE (reprint author), Swansea Univ, Dept Publ Hlth & Policy Studies, Singleton Pk, Swansea SA21 8PP, W Glam, Wales.
EM C.E.Macaulay@swansea.ac.uk
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NR 73
TC 1
Z9 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1081-4159
EI 1465-7325
J9 J DEAF STUD DEAF EDU
JI J. Deaf Stud. Deaf Educ.
PD OCT
PY 2013
VL 18
IS 4
BP 545
EP 562
DI 10.1093/deafed/ent019
PG 18
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 267DV
UT WOS:000328077800007
PM 23614903
ER
PT J
AU Mousavizadeh, K
Askari, M
Arian, H
Gourjipour, F
Nikpour, AR
Tavafjadid, M
Aryani, O
Kamalidehghan, B
Maroof, HR
Houshmand, M
AF Mousavizadeh, Kazem
Askari, Mohammad
Arian, Hajar
Gourjipour, Fazel
Nikpour, Amin R.
Tavafjadid, Maryam
Aryani, Omid
Kamalidehghan, Behnam
Maroof, Hamid R.
Houshmand, Massoud
TI Association of human mtDNA mutations with autism in Iranian patients
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Letter
ID MITOCHONDRIAL-DNA; SPECTRUM DISORDER
C1 [Mousavizadeh, Kazem; Tavafjadid, Maryam] Cellular & Mol Res Ctr, Dept Mol Biol, Tehran, Iran.
[Askari, Mohammad] Coll Allied Med, Dept Biotechnol, Tehran, Iran.
[Arian, Hajar; Aryani, Omid; Maroof, Hamid R.; Houshmand, Massoud] Special Med Ctr, Dept Med Genet, Tehran, Iran.
[Gourjipour, Fazel] Univ Tehran Med Sci, Sch Publ Hlth, HIV Mol Res Lab, Dept Mol Biol, Tehran, Iran.
[Gourjipour, Fazel] Univ Tehran Med Sci, Hlth Res Inst, Tehran, Iran.
[Nikpour, Amin R.] Kerman Univ Med Sci, Dept Immunol, Kerman, Iran.
[Kamalidehghan, Behnam] Univ Malaya, Fac Med, Dept Pharm, Kuala Lumpur, Malaysia.
[Houshmand, Massoud] Natl Inst Genet Engn & Biotechnol, Dept Med Genet, Tehran, Iran.
RP Houshmand, M (reprint author), Natl Inst Genet Engn & Biotechnol, Dept Med Genet, Tehran, Iran.
EM massoudh@nigeb.ac.ir
CR Bayou Nadia, 2008, Tunis Med, V86, P573
Alvarez-Iglesias V, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-50
Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472
Rossignol DA, 2011, MOL PSYCHIATR, V17, P290
Virgilio R, 2009, J NEUROL SCI, V281, P85, DOI 10.1016/j.jns.2009.01.025
Weissman JR, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003815
Zhang BD, 2010, J NEUROINFLAMM, V7, DOI 10.1186/1742-2094-7-80
NR 7
TC 0
Z9 0
PU ISFAHAN UNIV MED SCIENCES
PI ISFAHAN
PA HEZARJERIB AVE, PO BOX 81745-319, ISFAHAN, 00000, IRAN
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD OCT
PY 2013
VL 18
IS 10
BP 926
EP 926
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 267QI
UT WOS:000328112200021
PM 24497871
ER
PT J
AU Sedeno, L
Moya, A
Baker, P
Ibanez, A
AF Sedeno, Lucas
Moya, Alvaro
Baker, Phil
Ibanez, Agustin
TI Contextual social cognition and fronto temporo-insular networks
SO REVISTA DE PSICOLOGIA SOCIAL
LA Spanish
DT Article
DE Social cognition; context; frontotemporal dementia; fronto-insular
lesions; neuropsychiatry and fronto-temporo-insular networks
ID PRIMATE PREFRONTAL CORTEX; HIGH-FUNCTIONING AUTISM; FRONTOTEMPORAL
DEMENTIA; ASPERGER-SYNDROME; BIPOLAR DISORDER; BEHAVIORAL VARIANT;
HEALTHY RELATIVES; DECISION-MAKING; SCHIZOPHRENIA; BRAIN
AB Social cognition relies on the implicit and subtle contextual information present during social interactions. We describe an anatomo-functional model, called SCNM (Social Context Network Model), to explain contextual processing in social situations. We also show how the alteration of the different nodes of the SCNM underlies social cognition deficits in frontotemporal dementia, fronto-insular lesions, neurodevelopmental diseases and other neuropsychiatric conditions. Classical decontextualized approaches of social cognition are discussed in light of recent studies based on the SCNM. This theoretical model provides a set of hypothesis that allows a better evaluation and understanding of the processes underlying social cognition deficits. Its clinical implementation comprises the development of more efficient diagnostic instruments to detect and characterize neurological and psychiatric diseases, alongside with the implementation of rehabilitation therapies that better mimic real life situations.
C1 [Sedeno, Lucas; Moya, Alvaro; Baker, Phil; Ibanez, Agustin] Inst Neurol Cognit INECO, LPEN, Buenos Aires, DF, Argentina.
[Sedeno, Lucas; Ibanez, Agustin] Univ Favaloro, RA-1860 Buenos Aires, DF, Argentina.
[Sedeno, Lucas; Ibanez, Agustin] Consejo Nacl Invest Cient & Tecn, RA-1055 Buenos Aires, DF, Argentina.
RP Ibanez, A (reprint author), Univ Favaloro, LPEN, Inst Neurol Cognit INECO, RA-1860 Buenos Aires, DF, Argentina.
EM aibanez@ineco.org.ar
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NR 87
TC 1
Z9 1
PU FUNDACION INFANCIA APRENDIZAJE
PI MADRID
PA NARANJO DE BULNES, 69 CIUDALCAMPO, SAN SEBASTIAN DE LOS REYES, MADRID,
28707, SPAIN
SN 0213-4748
J9 REV PSICOL SOC
JI Rev. Psicol. Soc.
PD OCT
PY 2013
VL 28
IS 3
BP 299
EP 315
PG 17
WC Psychology, Social
SC Psychology
GA 260GY
UT WOS:000327584200004
ER
PT J
AU Hamza, RT
Hewedi, DH
Sallam, MT
AF Hamza, Rasha T.
Hewedi, Doaa H.
Sallam, Mahmoud T.
TI Iodine Deficiency in Egyptian Autistic Children and Their Mothers:
Relation to Disease Severity
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Autism; Egyptian; Iodine deficiency; Maternal hypothyroxinemia; Severity
ID THYROID-STIMULATING HORMONE; UNITED-STATES; NATIONAL-HEALTH; REELIN;
NUTRITION; PREGNANCY; GENE; ASSOCIATION; DISORDERS; SERUM
AB Background and Aims. Because autism may be a disease of early fetal brain development, maternal hypothyroxinemia (HT) in early pregnancy secondary to iodine deficiency (ID) may be related to etiology of autism. The aim of the study was to assess the iodine nutritional status in Egyptian autistic children and their mothers and its relationship with disease characteristics.
Methods. Fifty autistic children and their mothers were studied in comparison to 50 controls. All subjects were subjected to clinical evaluation, measurement of urinary iodine (UI), free triiodothyronine (fT(3)), free tetraiodothyronine (fT(4)) and thyroid-stimulating hormone (TSH) along with measurement of thyroid volume (TV). In addition, electroencephalography (EEG) and intelligence quotient (IQ) assessment were done for all autistic children.
Results. Of autistic children and their mothers, 54% and 58%, respectively, were iodine deficient. None of the control children or their mothers was iodine deficient. UI was lower among autistic patients (p < 0.001) and their mothers (p <0.001). Childhood Autism Rating Scale (CARS) score correlated negatively with UI (r = -0.94,p <0.001). Positive correlations were detected between autistic patients and their mothers regarding UI (r = 0.88, p <0.001), fT3 (r = 0.79, p = 0.03), fT(4) (r = 0.91, p <0.001) and TSH (r = 0.69, p = 0.04). Autism had a significant risk for association with each of low UI (OR: 9.5, 95% CI: 2.15-33.8, p = 0.02) and intake of noniodized salt (OR: 6.82, 95% CI = 1.36-34.27, p = 0.031).
Conclusions. ID is prevalent in Egyptian autistic children and their mothers and was inversely related to disease severity and could be related to its etiology. (C) 2013 IMSS. Published by Elsevier Inc.
C1 [Hamza, Rasha T.] Ain Shams Univ, Fac Med, Dept Pediat, Cairo 11371, Egypt.
[Hewedi, Doaa H.] Ain Shams Univ, Fac Med, Dept Psychiat, Cairo 11371, Egypt.
[Sallam, Mahmoud T.] Natl Res Ctr, Dept Clin & Chem Pathol, Cairo, Egypt.
RP Hamza, RT (reprint author), Ain Shams Univ, Fac Med, 36 Hisham Labib St,Off Makram Ebeid St, Cairo 11371, Egypt.
EM rashatarif_2000@hotmail.com
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NR 38
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD OCT
PY 2013
VL 44
IS 7
BP 555
EP 561
DI 10.1016/j.arcmed.2013.09.012
PG 7
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 257VR
UT WOS:000327416400011
PM 24120386
ER
PT J
AU Mathews, TL
Erkfritz-Gay, KN
Knight, J
Lancaster, BM
Kupzyk, KA
AF Mathews, Therese L.
Erkfritz-Gay, Karyn N.
Knight, Jessica
Lancaster, Blake M.
Kupzyk, Kevin A.
TI The Effects of Social Skills Training on Children With Autism Spectrum
Disorders and Disruptive Behavior Disorders
SO CHILDRENS HEALTH CARE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; ASPERGERS-SYNDROME; INTERVENTIONS;
RECOMMENDATIONS; ADOLESCENTS; STUDENTS; PROGRAM
AB Children with autism spectrum disorders (ASD) and disruptive behavior disorders (DBD) have significant difficulties in social interactions. Although social skills training (SST) is often prescribed for children with ASD and DBD, research showing its effectiveness is still emerging. This study examined the effects of SST for children with ASD and DBD. Evaluation measures included the Social Skills Improvement System, direct observation of behaviors during role-play, and social validity ratings. Direct observation data showed that participants successfully acquired the skills during the group, and the skills were maintained 1-month posttreatment. Social validity data revealed the intervention was well-received.
C1 [Mathews, Therese L.] Univ Nebraska, Med Ctr, Munroe Meyer Inst, Omaha, NE 68198 USA.
[Erkfritz-Gay, Karyn N.] Kishwaukee Community Hosp, Child Dev Clin, Sycamore, IL USA.
[Knight, Jessica] Childrens Hosp & Med Ctr, Omaha, NE USA.
[Lancaster, Blake M.] Univ Michigan Hlth Syst, Ann Arbor, MI USA.
[Kupzyk, Kevin A.] Univ Nebraska, Coll Nursing, Omaha, NE 68198 USA.
RP Mathews, TL (reprint author), Univ Nebraska, Med Ctr, Munroe Meyer Inst, 985380 Nebraska Med Ctr, Omaha, NE 68198 USA.
EM tmathews@unmc.edu
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NR 38
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0273-9615
EI 1532-6888
J9 CHILD HEALTH CARE
JI Child. Health Care
PD OCT 1
PY 2013
VL 42
IS 4
BP 311
EP 332
DI 10.1080/02739615.2013.842458
PG 22
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 256FQ
UT WOS:000327295500002
ER
PT J
AU Kishida, KT
Montague, PR
AF Kishida, Kenneth T.
Montague, P. Read
TI Economic probes of mental function and the extraction of computational
phenotypes
SO JOURNAL OF ECONOMIC BEHAVIOR & ORGANIZATION
LA English
DT Article
DE Neuroeconomics; fMRI; Trust game; Mental disorders; Autism; Phenotype
ID TEMPORAL DIFFERENCE MODELS; HUMAN VENTRAL STRIATUM; CINGULATE CORTEX;
REWARD; BRAIN; PREDICTION; TRUST; COOPERATION; OXYGENATION; REPUTATION
AB Economic games are now routinely used to characterize human cognition across multiple dimensions. These games allow for effective computational modeling of mental function because they typically come equipped with notions of optimal play, which provide quantitatively prescribed target functions that can be tracked throughout an experiment. The combination of these games, computational models, and neuroimaging tools open up the possibility for new ways to characterize normal cognition and associated brain function. We propose that these tools may also be used to characterize mental dysfunction, such as that found in a range of psychiatric illnesses. We describe early efforts using a multi-round trust game to probe brain responses associated with healthy social exchange and review how this game has provided a novel and useful characterization of autism spectrum disorder. Lastly, we use the multi-round trust game as an example to discuss how these kinds of games could produce novel bases for representing healthy behavior and brain function and thus provide objectively identifiable subtypes within a broad spectrum of mental function. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
C1 [Kishida, Kenneth T.; Montague, P. Read] Virginia Tech Caril Res Inst, Human Neuroimaging Lab, Roanoke, VA 24016 USA.
[Kishida, Kenneth T.; Montague, P. Read] Virginia Tech Caril Res Inst, Computat Psychiat Unit, Roanoke, VA 24016 USA.
[Montague, P. Read] Virginia Polytech Inst & State Univ, Dept Phys, Blacksburg, VA 24061 USA.
[Montague, P. Read] UCL, Wellcome Trust Ctr Neuroimaging, London WCN1 3BG, England.
RP Kishida, KT (reprint author), Virginia Tech Caril Res Inst, Human Neuroimaging Lab, 2 Riverside Circle, Roanoke, VA 24016 USA.
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NR 37
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-2681
EI 1879-1751
J9 J ECON BEHAV ORGAN
JI J. Econ. Behav. Organ.
PD OCT
PY 2013
VL 94
BP 234
EP 241
DI 10.1016/j.jebo.2013.07.009
PG 8
WC Economics
SC Business & Economics
GA 254NL
UT WOS:000327172300019
ER
PT J
AU Bilaver, LA
Jordan, N
AF Bilaver, Lucy A.
Jordan, Neil
TI Impact of State Mental Health Parity Laws on Access to Autism Services
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID ADVERSE SELECTION; FINANCIAL BURDEN; CARE NEEDS; CHILDREN; LEGISLATION
AB Objectives: This study examined the effect of state mental health parity laws on family financial burden, satisfaction with health insurance, and receipt of needed mental health services for privately insured children ages three to 17 with autism spectrum disorder (ASD). Methods: Data came from the 2005-2006 wave of the National Survey of Children With Special Health Care Needs. An econometric approach with instrumental variables was used to control for the nonrandom selection of states according to their mental health parity laws. The study analyzed data for 949 youths with ASD and private health insurance. Six outcome variables were examined, including several measures of family financial burden, satisfaction with health insurance, and receipt of needed mental health services. Results: Families of children needing mental health services and living in a state with a strict parity law had a 61% higher probability of reporting out-of-pocket spending >$ 1,000 compared with those not living in a strict parity state. Compared with families of children living in a strict parity state that did not specify ASD, those living in a strict parity state that specified ASD had a 92% higher probability of reporting unreasonable out-of-pocket spending. All other results were statistically insignificant. Conclusions: In contrast with previous research, this study did not find strong evidence that state mental health parity laws positively affected service access for children with ASD. Future research on the effect of autism insurance reform will provide a more precise test of the impact of insurance mandates on improving access to treatment services for children with ASD.
C1 [Bilaver, Lucy A.] No Illinois Univ, Sch Nursing & Hlth Studies, De Kalb, IL 60155 USA.
[Jordan, Neil] Northwestern Univ, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
RP Bilaver, LA (reprint author), No Illinois Univ, Sch Nursing & Hlth Studies, Wirtz Hall 235, De Kalb, IL 60155 USA.
EM lbilaver@niu.edu
FU National Institute on Disability and Rehabilitation Research
[H133P080006]
FX This work was funded by grant H133P080006 from the Advanced
Rehabilitation Training Program of the National Institute on Disability
and Rehabilitation Research.
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NR 22
TC 2
Z9 2
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD OCT
PY 2013
VL 64
IS 10
BP 967
EP 973
DI 10.1176/appi.ps.201200411
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health;
Psychiatry
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Psychiatry
GA 255ZH
UT WOS:000327278200015
PM 23771517
ER
PT J
AU Semansky, RM
Xie, M
Lawer, LJ
Mandell, DS
AF Semansky, Rafael M.
Xie, Ming
Lawer, Lindsay J.
Mandell, David S.
TI How States Use Medicaid to Fund Community-Based Services to Children
With Autism Spectrum Disorders
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID BEHAVIORAL HEALTH-CARE
AB Objective: This study examined the extent to which state Medicaid agencies funded 16 services for children with autism spectrum disorders: individual therapy, physical and occupational therapy, in-home supports, speech therapy, diagnostic assessment, behavior modification, family therapy, case management, targeted case management, respite, day treatment, social skills training, habilitation services, treatment planning, family education and training, and assistive communication devices. Methods: Procedure codes in the Medicaid Analytic eXtract (MAX) "other therapies" file were used to identify community-based services commonly delivered to children with a diagnosis of a primary autism spectrum disorder. Results: Four services are commonly used to address the core deficits of these disorders: physical and occupational therapy, speech therapy, behavior modification, and social skills training. Only six states funded all four services. Conclusions: States varied considerably in use of Medicaid to reimburse these services, indicating that some states may have opportunities to receive federal matching funds.
C1 [Semansky, Rafael M.] Econometrica Inc, Hlth Grp, Bethesda, MD USA.
[Xie, Ming; Mandell, David S.] Univ Penn, Dept Psychiat, Perleman Sch Med, Philadelphia, PA 19104 USA.
[Lawer, Lindsay J.] Drexel Univ, AJ Drexel Autism Inst, Philadelphia, PA 19104 USA.
RP Semansky, RM (reprint author), Econometrica Inc, Hlth Grp, 7475 Wisconsin Ave,Suite 1000, Bethesda, MD USA.
EM rsemansky@econometricainc.com
RI Mandell, David/H-2730-2012
OI Mandell, David/0000-0001-8240-820X
FU National Institute of Mental Health (NIMH) ("Interstate Variation in
Health Care and Utilization among Children with Autism Spectrum
Disorders") [MH077000-01]
FX This study was funded by grant MH077000-01 from the National Institute
of Mental Health (NIMH) ("Interstate Variation in Health Care and
Utilization among Children with Autism Spectrum Disorders"). The authors
thank Michele DeFelice Haverly, M.S., Deb Dunn, J.D., Maureen Davey,
Ph.D., Steve Eiken, B.A., M.P.A., Chris Koyanagi, Debra Langer, M.P.A.,
M.Sc., and Gail Stein, M.S.W., M.Ed., for helpful suggestions and
comments on earlier drafts. All views expressed are those of the authors
and do not necessarily reflect the views of NIMH.
CR [Anonymous], 2008, FOLL RUL REP FED RUL
[Anonymous], 1987, INT CLASSIFICATION D
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NR 13
TC 0
Z9 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD OCT
PY 2013
VL 64
IS 10
BP 1051
EP 1055
DI 10.1176/appi.ps.201200390
PG 5
WC Health Policy & Services; Public, Environmental & Occupational Health;
Psychiatry
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Psychiatry
GA 255ZH
UT WOS:000327278200028
PM 24081405
ER
PT J
AU Plummer, JT
Evgrafov, OV
Bergman, MY
Friez, M
Haiman, CA
Levitt, P
Aldinger, KA
AF Plummer, J. T.
Evgrafov, O. V.
Bergman, M. Y.
Friez, M.
Haiman, C. A.
Levitt, P.
Aldinger, K. A.
TI Transcriptional regulation of the MET receptor tyrosine kinase gene by
MeCP2 and sex-specific expression in autism and Rett syndrome
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
DE autistic disorder; gene expression regulation; methyl-CpG-binding
protein 2
ID BINDING PROTEIN MECP2; RARE DE-NOVO; SPECTRUM DISORDERS;
NEURODEVELOPMENTAL DISORDERS; NEUROLOGICAL DISEASE; BDNF TRANSCRIPTION;
DOWN-REGULATION; METHYLATED DNA; SYNDROME BRAIN; TARGET GENE
AB Single nucleotide variants (SNV) in the gene encoding the MET receptor tyrosine kinase have been associated with an increased risk for autism spectrum disorders (ASD). The MET promoter SNV rs1858830 C 'low activity' allele is enriched in ASD, associated with reduced protein expression, and impacts functional and structural circuit connectivity in humans. To gain insight into the transcriptional regulation of MET on ASD-risk etiology, we examined an interaction between the methyl CpG-binding protein 2 (MeCP2) and the MET 50 promoter region. Mutations in MeCP2 cause Rett syndrome (RTT), a predominantly female neurodevelopmental disorder sharing some ASD clinical symptoms. MeCP2 binds to a region of the MET promoter containing the ASD-risk SNV, and displays rs1858830 genotype-specific binding in human neural progenitor cells derived from the olfactory neuroepithelium. MeCP2 binding enhances MET expression in the presence of the rs1858830 C allele, but MET transcription is attenuated by RTT-specific mutations in MeCP2. In the postmortem temporal cortex, a region normally enriched in MET, gene expression is reduced dramatically in females with RTT, although not due to enrichment of the rs1858830 C 'low activity' allele. We newly identified a sex-based reduction in MET expression, with male ASD cases, but not female ASD cases compared with sex-matched controls. The experimental data reveal a prominent allele-specific regulation of MET transcription by MeCP2. The mechanisms underlying the pronounced reduction of MET in ASD and RTT temporal cortex are distinct and likely related to factors unique to each disorder, including a noted sex bias.
C1 [Plummer, J. T.; Evgrafov, O. V.; Levitt, P.; Aldinger, K. A.] Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90033 USA.
[Evgrafov, O. V.] Univ So Calif, Keck Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90033 USA.
[Bergman, M. Y.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
[Friez, M.] Greenwood Genet Ctr, Greenwood, SC 29646 USA.
[Haiman, C. A.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Levitt, P.] Univ So Calif, Keck Sch Med, Dept Cell & Neurobiol, Los Angeles, CA 90033 USA.
RP Aldinger, KA (reprint author), Seattle Childrens Res Inst, Ctr Integrat Brain Res, 1900 9th Ave, Seattle, WA 98101 USA.
EM kimberly.aldinger@seattlechildrens.org
FU NIH [MH067842]; Epilepsy Foundation of Greater Los Angeles fellowship
FX The authors thank Valeria Spitsyna and Evan Cohen for technical
assistance. This work was supported by NIH grant MH067842 to PL and an
Epilepsy Foundation of Greater Los Angeles fellowship to KAA.
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NR 74
TC 3
Z9 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD OCT
PY 2013
VL 3
AR e316
DI 10.1038/tp.2013.91
PG 8
WC Psychiatry
SC Psychiatry
GA 258QC
UT WOS:000327472800009
PM 24150225
ER
PT J
AU Spiers, N
AF Spiers, Nicola
TI Cohort effects explain the increase in autism diagnosis among children
born from 1992 to 2003 in California
SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
LA English
DT Letter
ID PERIOD; AGE
C1 Univ Leicester, Dept Hlth Sci, Acad Unit Social & Epidemiol Psychiat, Leicester LE1 7RH, Leics, England.
RP Spiers, N (reprint author), Univ Leicester, Dept Hlth Sci, Acad Unit Social & Epidemiol Psychiat, Leicester LE1 7RH, Leics, England.
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PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0300-5771
EI 1464-3685
J9 INT J EPIDEMIOL
JI Int. J. Epidemiol.
PD OCT
PY 2013
VL 42
IS 5
BP 1520
EP 1521
DI 10.1093/ije/dyt029
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 248TI
UT WOS:000326726000045
PM 24159079
ER
PT J
AU Keyes, KM
Bearman, P
AF Keyes, Katherine M.
Bearman, Peter
TI Authors' Response to: Cohort effects explain the increase in autism
diagnosis among children born from 1992 to 2003 in California
SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
LA English
DT Letter
C1 [Keyes, Katherine M.; Bearman, Peter] Columbia Univ, New York, NY 10027 USA.
RP Keyes, KM (reprint author), Columbia Univ, New York, NY 10027 USA.
EM psb17@columbia.edu
CR Keyes KM, 2010, SOC SCI MED, V70, P1100, DOI 10.1016/j.socscimed.2009.12.018
Keyes KM, 1976, ARCH GEN PSYCHIAT
Keyes KM, 2012, INT J EPIDEMIOL, V41, P495, DOI 10.1093/ije/dyr193
Keyes KM, 2010, ANN EPIDEMIOL, V20, P779, DOI 10.1016/j.annepidem.2010.03.006
NR 4
TC 1
Z9 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0300-5771
EI 1464-3685
J9 INT J EPIDEMIOL
JI Int. J. Epidemiol.
PD OCT
PY 2013
VL 42
IS 5
BP 1521
EP 1521
DI 10.1093/ije/dyt030
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 248TI
UT WOS:000326726000046
PM 24159080
ER
PT J
AU Kerr, TM
Muller, CL
Miah, M
Jetter, CS
Pfeiffer, R
Shah, C
Baganz, N
Anderson, GM
Crawley, JN
Sutcliffe, JS
Blakely, RD
Veenstra-VanderWeele, J
AF Kerr, Travis M.
Muller, Christopher L.
Miah, Mahfuzur
Jetter, Christopher S.
Pfeiffer, Rita
Shah, Charisma
Baganz, Nicole
Anderson, George M.
Crawley, Jacqueline N.
Sutcliffe, James S.
Blakely, Randy D.
Veenstra-VanderWeele, Jeremy
TI Genetic background modulates phenotypes of serotonin transporter Ala56
knock-in mice
SO MOLECULAR AUTISM
LA English
DT Article
DE Serotonin; Monoamine; Transporter; Receptor; Autism; Compulsive
ID AUTISM SPECTRUM DISORDERS; WHOLE-BLOOD SEROTONIN; NULL MUTANT MICE;
MOUSE MODEL; RETT-SYNDROME; MENTAL-RETARDATION; GENOMEWIDE SCREEN;
SOCIAL BEHAVIORS; TWIN PAIRS; ANXIETY
AB Background: Previously, we identified multiple, rare serotonin (5-HT) transporter (SERT) variants in children with autism spectrum disorder (ASD). Although in our study the SERT Ala56 variant was over-transmitted to ASD probands, it was also seen in some unaffected individuals, suggesting that associated ASD risk is influenced by the epistatic effects of other genetic variation. Subsequently, we established that mice expressing the SERT Ala56 variant on a 129S6/S4 genetic background display multiple biochemical, physiological and behavioral changes, including hyperserotonemia, altered 5-HT receptor sensitivity, and altered social, communication, and repetitive behavior. Here we explore the effects of genetic background on SERT Ala56 knock-in phenotypes.
Methods: To explore the effects of genetic background, we backcrossed SERT Ala56 mice on the 129 background into a C57BL/6 (B6) background to achieve congenic B6 SERT Ala56 mice, and assessed autism-relevant behavior, including sociability, ultrasonic vocalizations, and repetitive behavior in the home cage, as well as serotonergic phenotypes, including whole blood serotonin levels and serotonin receptor sensitivity.
Results: One consistent phenotype between the two strains was performance in the tube test for dominance, where mutant mice displayed a greater tendency to withdraw from a social encounter in a narrow tube as compared to wildtype littermate controls. On the B6 background, mutant pup ultrasonic vocalizations were significantly increased, in contrast to decreased vocalizations seen previously on the 129 background. Several phenotypes seen on the 129 background were reduced or absent when the mutation was placed on the B6 background, including hyperserotonemia, 5-HT receptor hypersensivity, and repetitive behavior.
Conclusions: Our findings provide a cogent example of how epistatic interactions can modulate the impact of functional genetic variation and suggest that some aspects of social behavior may be especially sensitive to changes in SERT function. Finally, these results provide a platform for the identification of genes that may modulate the risk of ASD in humans.
C1 [Kerr, Travis M.; Jetter, Christopher S.; Shah, Charisma; Sutcliffe, James S.; Blakely, Randy D.; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37232 USA.
[Muller, Christopher L.; Miah, Mahfuzur; Blakely, Randy D.; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Vanderbilt Brain Inst, Nashville, TN 37232 USA.
[Pfeiffer, Rita; Baganz, Nicole; Blakely, Randy D.; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA.
[Anderson, George M.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA.
[Crawley, Jacqueline N.] Univ Calif Davis, Med Invest Neurodev Disorders MIND Inst, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
[Sutcliffe, James S.] Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
[Blakely, Randy D.; Veenstra-VanderWeele, Jeremy] Silvio O Conte Ctr Neurosci Res, Nashville, TN 37232 USA.
[Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Pediat, Nashville, TN 37232 USA.
[Veenstra-VanderWeele, Jeremy] Vanderbilt Kennedy Ctr Res Human Dev, Treatment & Res Inst Autism Spectrum Disorder, Nashville, TN 37232 USA.
RP Veenstra-VanderWeele, J (reprint author), Vanderbilt Univ, Dept Psychiat, 465 21st Ave S, Nashville, TN 37232 USA.
EM j.vvw@vanderbilt.edu
RI Sutcliffe, James/C-1348-2012
OI Sutcliffe, James/0000-0001-5200-6007
FU NIH [MH081066, MH094604, HD065278, R25GM097634, HD15052]; Autism Speaks
Pilot Grant; American Academy of Child and Adolescent Psychiatry Pilot
Award
FX This work was supported by NIH grants MH081066 (JV), MH094604 (JV),
HD065278 (RB), R25GM097634 (MM), an Autism Speaks Pilot Grant (JV), an
American Academy of Child and Adolescent Psychiatry Pilot Award (JV) and
Junior Investigator Award (JV), and an NIH grant to the Vanderbilt
Kennedy Center (HD15052).
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NR 67
TC 4
Z9 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD OCT 1
PY 2013
VL 4
AR 35
DI 10.1186/2040-2392-4-35
PG 11
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254YE
UT WOS:000327204900001
PM 24083388
ER
PT J
AU Ali, EHA
Elgoly, AHM
AF Ali, Elham H. A.
Elgoly, Amany H. Mahmoud
TI Combined prenatal and postnatal butyl paraben exposure produces
autism-like symptoms in offspring: Comparison with valproic acid
autistic model
SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
LA English
DT Article
DE Butyl paraben; Valproic acid; Autism; Monoamines; Glutamate; BDNF
ID PERVASIVE DEVELOPMENTAL DISORDERS; MALE REPRODUCTIVE-SYSTEM; LONG-TERM
POTENTIATION; FACTOR MESSENGER-RNA; NEUROTROPHIC FACTOR; ANIMAL-MODEL;
SEROTONIN SYNTHESIS; PARKINSONS-DISEASE; PREFRONTAL CORTEX;
BRAIN-DEVELOPMENT
AB The aim of this work is to evaluate the impact of butyl paraben (BP) in brain of the pups developed for mothers administered BP from early pregnancy till weaning and its effect on studying the behavior, brain neurotransmitters and brain derived neurotrophic factor BDNF via comparing the results with valproic acid (VA) autistic-rat model preparing by a single oral injection dose of VA (800 mg/kg b.wt) at the 12.5 days of gestation. Butyl paraben was orally and subcutaneously administered (200 mg/kg b.wt) to pregnant rats from gestation day 1 to lactation day 21. The offspring male rats were subjected at the last 3 days of lactation to Morris water maze and three chamber sociability test then decapitated and the brain was excised and dissected to the cortex, hippocampus, cerebellum, midbrain and pans for the determination of norepinephrine, dopamine and serotonin (NE, DA and 5-HT) and cortex amino adds and whole brain BDNF. The results showed similar social and learning and memory behavioral deficits in VA rat model and the butyl paraben offspring in comparison With the controls. Also, some similar alterations were observed in monoamine content, amino acids and BDNF factor in the autistic-like model and butyl paraben offspring in comparison with the controls. The alterations were recorded notably in hippocampus and pons NE, midbrain DA, hippocampus and midbrain 5-HT, and frontal cortex GABA and asparagine. These data suggest that prenatal exposure to butyl paraben induced neuro-developmental disorders similar to some of the neurodevelopmental disorders observed in the VA model of autism. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Ali, Elham H. A.] Ain Shams Univ, Dept Zool, Fac Women Arts Sci & Educ, Cairo, Egypt.
[Elgoly, Amany H. Mahmoud] NODCAR, Hormone Evaluat Dept, Giza, Egypt.
RP Ali, EHA (reprint author), Fac Women, 1 Asmaa Fahmy St, Cairo, Egypt.
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*SCCS EU SCI COMM, OP PAR
Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010
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Wang M, 2004, SCIENCE, V303, P853, DOI 10.1126/science.1091162
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NR 106
TC 5
Z9 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0091-3057
J9 PHARMACOL BIOCHEM BE
JI Pharmacol. Biochem. Behav.
PD OCT
PY 2013
VL 111
BP 102
EP 110
DI 10.1016/j.pbb.2013.08.016
PG 9
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA 252FV
UT WOS:000326991400016
PM 24036472
ER
PT J
AU Franklin, K
AF Franklin, Karen
TI Zero Degrees of Empathy: A New Theory of Human Cruelty and Kindness
SO JOURNAL OF BIOETHICAL INQUIRY
LA English
DT Book Review
DE Empathy; Evil; Autism; Psychopathy; fMRI
C1 [Franklin, Karen] Bond Univ, Robina, Qld, Australia.
RP Franklin, K (reprint author), Bond Univ, Robina, Qld, Australia.
EM mail@karenfranklin.com
CR Arendt H., 1963, EICHMANN JERUSALEM R
Baron-Cohen S., 2011, ZERO DEGREES EMPATHY
Barry-Walsh JB, 2004, J FORENSIC PSYCHI PS, V15, P96, DOI 10.1080/14789940310001638628
COHEN SB, 2011, ZERO DEGREES EMPATHY
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Guay JP, 2007, J ABNORM PSYCHOL, V116, P701, DOI 10.1037/0021-843X.116.4.701
Jack AI, 2013, NEUROIMAGE, V66, P385, DOI 10.1016/j.neuroimage.2012.10.061
MURRIE D. C., 2002, INT J FORENSIC MENTA, V1, P59, DOI DOI 10.1080/14999013.2002.10471161
Pinker S., 2011, BETTER ANGELS OUR NA
Zimbardo P., 2008, LUCIFER EFFECT UNDER
NR 10
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1176-7529
EI 1872-4353
J9 J BIOETHIC INQ
JI J. Bioethical Inq.
PD OCT
PY 2013
VL 10
IS 3
BP 411
EP 413
DI 10.1007/s11673-013-9452-9
PG 3
WC Ethics; Medical Ethics; Social Issues; Social Sciences, Biomedical
SC Social Sciences - Other Topics; Medical Ethics; Social Issues;
Biomedical Social Sciences
GA 238QE
UT WOS:000325961700017
ER
PT J
AU Chun, TH
Katz, ER
Duffy, SJ
AF Chun, Thomas H.
Katz, Emily R.
Duffy, Susan J.
TI Pediatric Mental Health Emergencies and Special Health Care Needs
SO PEDIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Psychiatric emergency; Pediatric; Autism; Developmental disorders
ID EXCHANGE COMMUNICATION-SYSTEM; ADOLESCENT SUICIDE ATTEMPTS; RANDOMIZED
CONTROLLED-TRIAL; ACUTELY AGITATED PATIENT; MEDICAL CLEARANCE;
INTRAMUSCULAR HALOPERIDOL; CLINICAL-TRIAL; UNITED-STATES; RISK-FACTORS;
FOLLOW-UP
AB Children with mental health problems are increasingly being evaluated and treated by both pediatric primary care and pediatric emergency physicians. This article focuses on the epidemiology, evaluation, and management of the 2 most common pediatric mental health emergencies, suicidal and homicidal/aggressive patients, as well as the equally challenging population of children with autism or other developmental disabilities.
C1 [Chun, Thomas H.; Duffy, Susan J.] Rhode Isl Hosp, Dept Emergency Med, Providence, RI 02903 USA.
[Chun, Thomas H.; Duffy, Susan J.] Rhode Isl Hosp, Dept Pediat, Providence, RI 02903 USA.
[Katz, Emily R.] Rhode Isl Hosp, Dept Child & Family Psychiat, Providence, RI 02903 USA.
RP Chun, TH (reprint author), Rhode Isl Hosp, Dept Emergency Med, Claverick 243,593 Eddy St, Providence, RI 02903 USA.
EM Thomas_Chun@brown.edu
FU "Teaching an Alcohol Intervention to Pediatric ER Staff", National
Institute for Alcohol Abuse and Alcoholism [K23 AA014934]; "Teen Alcohol
Screening in the Pediatric Emergency Care Applied Research Network",
National Institute for Alcohol Abuse and Alcoholism [R01 AA021900]
FX Supported in part by "Teaching an Alcohol Intervention to Pediatric ER
Staff," National Institute for Alcohol Abuse and Alcoholism, K23
AA014934 and "Teen Alcohol Screening in the Pediatric Emergency Care
Applied Research Network," National Institute for Alcohol Abuse and
Alcoholism, R01 AA021900 (T.H. Chun).
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NR 62
TC 1
Z9 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0031-3955
EI 1557-8240
J9 PEDIATR CLIN N AM
JI Pediatr. Clin. N. Am.
PD OCT
PY 2013
VL 60
IS 5
BP 1185
EP +
DI 10.1016/j.pcl.2013.06.006
PG 18
WC Pediatrics
SC Pediatrics
GA 247XW
UT WOS:000326659300012
PM 24093903
ER
PT J
AU Ameis, SH
Corbett-Dick, P
Cole, L
Correll, CU
AF Ameis, Stephanie H.
Corbett-Dick, Patricia
Cole, Lynn
Correll, Christoph U.
TI Decision Making and Antipsychotic Medication Treatment for Youth With
Autism Spectrum Disorders: Applying Guidelines in the Real World
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Editorial Material
ID PERVASIVE DEVELOPMENTAL DISORDERS; 2ND-GENERATION ANTIPSYCHOTICS;
MALADAPTIVE AGGRESSION; BEHAVIORAL SYMPTOMS; CHILDREN; ADOLESCENTS;
MANAGEMENT; RISPERIDONE
C1 [Ameis, Stephanie H.] Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
[Ameis, Stephanie H.] Univ Toronto, Hosp Sick Children, Dept Psychiat, Toronto, ON M5G 1X8, Canada.
[Corbett-Dick, Patricia; Cole, Lynn] Univ Rochester, Sch Nursing, Med Ctr, Div Neurodev & Behav Pediat, Rochester, NY 14627 USA.
[Correll, Christoph U.] Zucker Hillside Hosp, Glen Oaks, NY 11004 USA.
[Correll, Christoph U.] Hofstra North Shore Long Isl Jewish Sch Med, Hempstead, NY USA.
RP Correll, CU (reprint author), Zucker Hillside Hosp, Div Psychiat Res, 75-59 263rd St, Glen Oaks, NY 11004 USA.
EM ccorrell@lij.edu
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US Dept Health and Human Services Substance Abuse and Mental Health Services Administration, SHAR DEC MAK MENT HL
NR 32
TC 1
Z9 1
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD OCT
PY 2013
VL 74
IS 10
BP 1022
EP 1024
DI 10.4088/JCP.13ac08691
PG 3
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 243KU
UT WOS:000326316100012
PM 24229756
ER
PT J
AU McQuaid, A
AF McQuaid, Abbie
TI Autism and employment
SO PSYCHOLOGIST
LA English
DT Letter
NR 0
TC 0
Z9 0
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0952-8229
J9 PSYCHOLOGIST
JI Psychologist
PD OCT
PY 2013
VL 26
IS 10
BP 706
EP 706
PG 1
WC Psychology, Multidisciplinary
SC Psychology
GA 244EA
UT WOS:000326368700010
ER
PT J
AU Drake, JE
Winner, E
AF Drake, Jennifer E.
Winner, Ellen
TI Who will become a 'super artist'?
SO PSYCHOLOGIST
LA English
DT Article
ID CAVE ART; AUTISM
AB Some young children are able to create stunningly realistic drawings resembling those of adult artists. Does this kind of 'super' drawing ability foretell a future adult artist? Here different kinds of exceptional child artists are examined, leading to the suggestion of six characteristics that are likely to be predictive of becoming an artist.
C1 [Drake, Jennifer E.] CUNY Brooklyn Coll, Brooklyn, NY 11210 USA.
[Winner, Ellen] Boston Coll, Chestnut Hill, MA 02167 USA.
RP Drake, JE (reprint author), CUNY Brooklyn Coll, Brooklyn, NY 11210 USA.
EM jdrake@brooklyn.cuny.edu; ellen.winner@bc.edu
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NR 25
TC 0
Z9 0
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0952-8229
J9 PSYCHOLOGIST
JI Psychologist
PD OCT
PY 2013
VL 26
IS 10
BP 730
EP 733
PG 4
WC Psychology, Multidisciplinary
SC Psychology
GA 244EA
UT WOS:000326368700025
ER
PT J
AU Bryant, RA
Hung, L
Dobson-Stone, C
Schofield, PR
AF Bryant, Richard A.
Hung, Lynette
Dobson-Stone, Carol
Schofield, Peter R.
TI The association between the oxytocin receptor gene (OXTR) and
hypnotizability
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Oxytocin; OXTR; Genetic; Hypnotizability; Absorption; COMT
ID HARVARD GROUP SCALE; HYPNOTIC-SUSCEPTIBILITY; SKIN-CONDUCTANCE;
EEG-ALPHA; HYPNOSIS; AUTISM; POLYMORPHISM; VASOPRESSIN; ABSORPTION;
OPENNESS
AB Hypnosis has puzzled scientists for centuries, and particularly the reason why some people are prone to engaging in suggested experiences discordant with external reality. Absorption in internal experience is one key component of the hypnotic response. The neuropeptide oxytocin has been posited to heighten sensitivity to external cues, and it is possible that individual differences in oxytocin-related capacity to engage in external or internal experiences influences hypnotic response. To test this proposal, 185 Caucasian individuals provided saliva samples for analysis of polymorphisms in the oxytocin receptor gene, COMT, and independently completed standardized measures of hypnotizability and absorption. Participants with the GG genotype at rs53576 were characterized by lower hypnotizability and absorption scores than those with the A allele; there was no association between hyponotizability and COMT. These findings provide initial evidence that the capacity to respond to suggestions for altered internal experience is influenced by the oxytocin receptor gene, and is consistent with evidence that oxytocin plays an important role in modulating the extent to which people engage with external versus internal experiences. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Bryant, Richard A.; Hung, Lynette] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
[Dobson-Stone, Carol; Schofield, Peter R.] Neurosci Res Australia, Sydney, NSW, Australia.
[Dobson-Stone, Carol; Schofield, Peter R.] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia.
RP Bryant, RA (reprint author), Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
EM r.bryant@unsw.edu.au
FU Australian Research Council
FX This project was funded by an Australian Research Council Discovery
Grant. The ARC had no further role in study design; in the collection,
analysis, and interpretation of data; in the writing of the report; and
in the decision to submit the paper for publication.
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NR 43
TC 4
Z9 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD OCT
PY 2013
VL 38
IS 10
BP 1979
EP 1984
DI 10.1016/j.psyneuen.2013.03.002
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 242BZ
UT WOS:000326213700004
PM 23562248
ER
PT J
AU Paula-Perez, I
AF Paula-Perez, Isabel
TI Differential diagnosis between obsessive compulsive disorder and
restrictive and repetitive behavioural patterns, activities and
interests in autism spectrum disorders
SO REVISTA DE PSIQUIATRIA Y SALUD MENTAL
LA Spanish
DT Review
DE Obsessive compulsive disorder; Autism spectrum disorders; Obsessions;
Compulsions; Restricted and repetitive patterns of behavior, interests
or activities
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; ANXIETY DISORDERS;
CONTROLLED-TRIAL; CHILDREN; ADULTS; INDIVIDUALS; ADOLESCENTS;
CONFIDENCE; THERAPY
AB Introduction: The obsessive compulsive disorder (OCD) and the restricted and repetitive patterns of behavior, interests and activities inherent to autism spectrum disorders (ASD) share a number of features that can make the differential diagnosis between them extremely difficult and lead to erroneous overdiagnosis of OCD in people with autism.
Development: In both cases there may appear to have a fixation on routine, ritualized patterns of verbal and nonverbal behavior, resistance to change, and highly restrictive interests, which becomes a real challenge for differentiating rituals, stereotypes and adherence to routines in ASD from obsessions and compulsions in OCD. This article provides key points to clarify this differential diagnosis through the analysis of emotional valence, content, function and psychological theories that explain the obsessions and compulsions in OCD, and the desire for sameness, stereotyped movements and limited interest in autism.
Conclusion: The terms "obsession" and "compulsion" should no longer be used when referring to patterns of behavior, interests or restricted and repetitive activities in autism due to syntonic characteristics, low perception of personal responsibility and low neutralizing efforts. Treatment focuses on changing the environment, the use of socio-communicative compensatory strategies and behavioral modification techniques to improve cognitive and behavioral flexibility. When there is comorbidity between, exposure behavioral and response prevention techniques are then used, followed by others of more cognitive orientation if necessary. (C) 2012 SEP y SEPB. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Paula-Perez, Isabel] Univ Barcelona, Dept Metodos Invest & Diagnost Educ, Barcelona, Spain.
[Paula-Perez, Isabel] Univ Barcelona, Barcelona, Spain.
RP Paula-Perez, I (reprint author), Univ Barcelona, Dept Metodos Invest & Diagnost Educ, Barcelona, Spain.
EM isabelpaula@ub.edu
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NR 37
TC 2
Z9 2
PU ELSEVIER DOYMA SL
PI BARCELONA
PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN
SN 1888-9891
EI 1989-4600
J9 REV PSIQUIATR SALUD
JI Rev. Psiquiatr. Salud Ment.
PD OCT-DEC
PY 2013
VL 6
IS 4
BP 178
EP 186
DI 10.1016/j.rpsm.2012.07.005
PG 9
WC Psychiatry
SC Psychiatry
GA 244UO
UT WOS:000326415900006
PM 23084795
ER
PT J
AU Vinet, E
Scott, S
Pineau, CA
Joseph, L
Clarke, AE
Fombonne, E
Platt, RW
Bernatsky, S
AF Vinet, Evelyne
Scott, Susan
Pineau, Christian A.
Joseph, Lawrence
Clarke, Ann E.
Fombonne, Eric
Platt, Robert W.
Bernatsky, Sasha
TI Increased Risk Of Autism Spectrum Disorders In Children Born To Women
With SLE: Preliminary Data From The OSLER Cohort.
SO ARTHRITIS AND RHEUMATISM
LA English
DT Meeting Abstract
CT 77th Annual Meeting of the American-College-of-Rheumatology / 48th
Annual Meeting of the Association-of-Rheumatology-Health-Professionals
CY OCT 25-30, 2013
CL San Diego, CA
SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Profess
C1 [Vinet, Evelyne; Scott, Susan; Pineau, Christian A.; Clarke, Ann E.; Bernatsky, Sasha] McGill Univ, Ctr Hlth, Montreal, PQ, Canada.
[Joseph, Lawrence; Platt, Robert W.] McGill Univ, Montreal, PQ, Canada.
[Fombonne, Eric] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-3591
EI 1529-0131
J9 ARTHRITIS RHEUM-US
JI Arthritis Rheum.
PD OCT
PY 2013
VL 65
SU 10
SI SI
MA 2831
BP S1212
EP S1213
PG 2
WC Rheumatology
SC Rheumatology
GA 230RF
UT WOS:000325359206259
ER
PT J
AU Theoharides, TC
Asadi, S
Panagiotidou, S
Weng, ZY
AF Theoharides, Theoharis C.
Asadi, Shahrzad
Panagiotidou, Smaro
Weng, Zuyi
TI The "missing link" in autoimmunity and autism: Extracellular
mitochondrial components secreted from activated live mast cells
SO AUTOIMMUNITY REVIEWS
LA English
DT Review
DE ATP; Autism; DNA; Inflammation; Mast cells; Mitochondria
ID SPECTRUM DISORDERS; RHEUMATOID-ARTHRITIS; IMMUNE DYSREGULATION;
HISTAMINE-SECRETION; BRAIN INFLAMMATION; MEDIATOR RELEASE; T-CELLS;
LUTEOLIN; CHILDREN; DISEASE
AB Autoimmune diseases continue to increase, but the reason(s) remain obscure and infections have not proven to be major contributors. Mast cells are tissue immune cells responsible for allergies, but have been increasingly shown to be involved in innate and acquired immunity, as well as inflammation. This involvement is possible because of their ability to release multiple mediators in response to a great variety of triggers. We recently published that activation of mast cells is accompanied by mitochondrial fission and translocation to the cell surface from where they secrete at least ATP and DNA outside the cell without cell damage. These extracellular mitochondrial components are misconstrued by the body as "innate pathogens" leading to powerful autocrine and paracrine auto-immune/auto-inflammatory responses. We also showed that mitochondrial DNA is increased in the serum of young children with autism spectrum disorders (ASD), a condition that could involve "focal brain allergy/encephalitits". Blocking the secretion of extracellular mitochondrial components could present unique possibilities for the therapy of ASD and other autoimmune diseases. Unique formulation of the flavonoid luteolin offers unique advantages. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Theoharides, Theoharis C.; Asadi, Shahrzad; Panagiotidou, Smaro; Weng, Zuyi] Tufts Univ, Sch Med, Dept Mol Physiol & Pharmacol, Mol Immunopharrnacol & Drug Discovely Lab, Boston, MA 02111 USA.
[Theoharides, Theoharis C.] Tufts Univ, Sch Med, Dept Biochem, Boston, MA 02111 USA.
[Theoharides, Theoharis C.] Tufts Univ, Sch Med, Dept Internal Med, Boston, MA 02111 USA.
[Theoharides, Theoharis C.] Tufts Univ, Sch Med, Tufts Med Ctr, Dept Psychiat, Boston, MA 02111 USA.
[Theoharides, Theoharis C.; Weng, Zuyi] Tufts Univ, Sackler Sch Grad Biomed Sci, Boston, MA 02111 USA.
[Asadi, Shahrzad] Tufts Med Ctr, Dept Pharm, Boston, MA USA.
RP Theoharides, TC (reprint author), Tufts Univ, Sch Med, Dept Mol Physiol & Pharmacol, 136 Harrison Ave,Suite J304, Boston, MA 02111 USA.
EM theoharis.theoharides@tufts.edu
FU US National Institutes of Health (NIH) [NS055681, AR47652, NS66205,
NS71361]; Autism Research Collaborative, the National Autism Association
and Safe Minds
FX Aspects of our work discussed here were supported in part by US National
Institutes of Health (NIH) grants NS055681; AR47652; NS66205; and
NS71361, as well as from the Autism Research Collaborative, the National
Autism Association and Safe Minds.
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Zuyi Weng, 2013, EXP BIOL, P9764
NR 124
TC 5
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1568-9972
EI 1873-0183
J9 AUTOIMMUN REV
JI Autoimmun. Rev.
PD OCT
PY 2013
VL 12
IS 12
BP 1136
EP 1142
DI 10.1016/j.autrev.2013.06.018
PG 7
WC Immunology
SC Immunology
GA 239GG
UT WOS:000326010000005
PM 23831684
ER
PT J
AU Redcay, E
Dodell-Feder, D
Mavros, PL
Kleiner, M
Pearrow, MJ
Triantafyllou, C
Gabrieli, JD
Saxe, R
AF Redcay, Elizabeth
Dodell-Feder, David
Mavros, Penelope L.
Kleiner, Mario
Pearrow, Mark J.
Triantafyllou, Christina
Gabrieli, John D.
Saxe, Rebecca
TI Atypical brain activation patterns during a face-to-face joint attention
game in adults with autism spectrum disorder
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE social; fMRI; superior temporal sulcus; medial prefrontal cortex
ID SUPERIOR TEMPORAL SULCUS; SCHOOL-AGED CHILDREN; SOCIAL COGNITION;
LANGUAGE-DEVELOPMENT; HUMAN INFANTS; GAZE; COMMUNICATION; OTHERS; FMRI;
MIND
AB Joint attention behaviors include initiating one's own and responding to another's bid for joint attention to an object, person, or topic. Joint attention abilities in autism are pervasively atypical, correlate with development of language and social abilities, and discriminate children with autism from other developmental disorders. Despite the importance of these behaviors, the neural correlates of joint attention in individuals with autism remain unclear. This paucity of data is likely due to the inherent challenge of acquiring data during a real-time social interaction. We used a novel experimental set-up in which participants engaged with an experimenter in an interactive face-to-face joint attention game during fMRI data acquisition. Both initiating and responding to joint attention behaviors were examined as well as a solo attention (SA) control condition. Participants included adults with autism spectrum disorder (ASD) (n = 13), a mean age- and sex-matched neurotypical group (n = 14), and a separate group of neurotypical adults (n = 22). Significant differences were found between groups within social-cognitive brain regions, including dorsal medial prefrontal cortex (dMPFC) and right posterior superior temporal sulcus (pSTS), during the RJA as compared to SA conditions. Region-of-interest analyses revealed a lack of signal differentiation between joint attention and control conditions within left pSTS and dMPFC in individuals with ASD. Within the pSTS, this lack of differentiation was characterized by reduced activation during joint attention and relative hyper-activation during SA. These findings suggest a possible failure of developmental neural specialization within the STS and dMPFC to joint attention in ASD. Hum Brain Mapp 34:2511-2523, 2013. (c) 2012 Wiley Periodicals, Inc.
C1 [Redcay, Elizabeth] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA.
[Dodell-Feder, David] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA.
[Mavros, Penelope L.; Triantafyllou, Christina; Gabrieli, John D.; Saxe, Rebecca] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Kleiner, Mario] Max Planck Inst Biol Cybernet, Dept Human Percept Cognit & Act, D-72076 Tubingen, Germany.
[Pearrow, Mark J.] MIT, Cambridge, MA 02139 USA.
[Triantafyllou, Christina; Gabrieli, John D.] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA.
RP Redcay, E (reprint author), Univ Maryland, 1147 Biol Psychol Bldg, College Pk, MD 20742 USA.
EM redcay@umd.edu
FU Simons Foundation Autism Research Initiative; Eunice Kennedy Shriver
National Institute of Child Health and Human Development
FX Contract grant sponsors: Simons Foundation Autism Research Initiative,
Eunice Kennedy Shriver National Institute of Child Health and Human
Development.
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NR 60
TC 10
Z9 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD OCT
PY 2013
VL 34
IS 10
BP 2511
EP 2523
DI 10.1002/hbm.22086
PG 13
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 216TI
UT WOS:000324306900012
PM 22505330
ER
PT J
AU Keehn, B
Shih, P
Brenner, LA
Townsend, J
Muller, RA
AF Keehn, Brandon
Shih, Patricia
Brenner, Laurie A.
Townsend, Jeanne
Mueller, Ralph-Axel
TI Functional connectivity for an "Island of sparing" in autism spectrum
disorder: An fMRI study of visual search
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE autism; attention; functional MRI; functional connectivity MRI; symptom
severity
ID EMBEDDED FIGURES TASK; CORTICAL UNDERCONNECTIVITY; STRUCTURAL
CONNECTIVITY; SENTENCE COMPREHENSION; RESPONSE-INHIBITION; SPATIAL
ATTENTION; COGNITIVE CONTROL; WORKING-MEMORY; HUMAN BRAIN; CORTEX
AB Although autism is usually characterized with respect to sociocommunicative impairments, visual search is known as a domain of relative performance strength in this disorder. This study used functional MRI during visual search in children with autism spectrum disorder (n = 19; mean age = 13;10) and matched typically developing children (n = 19; mean age = 14;0). We selected regions of interest within two attentional networks known to play a crucial role in visual search processes, such as goal-directed selective attention, filtering of irrelevant distractors, and detection of behaviorally-relevant information, and examined activation and connectivity within and between these attentional networks. Additionally, based on prior research suggesting links between visual search abilities and autism symptomatology, we tested for correlations between sociocommunicative impairments and behavioral and neural indices of search. Contrary to many previous functional connectivity magnetic resonance imaging studies of autism that reported functional underconnectivity for task domains of weakness, we found atypically increased connectivity within and between attentional networks in autism. Additionally, we found increased functional connectivity for occipital regions, both locally and for long-distance connections with frontal regions. Both behavioral and neural indices of search were correlated with sociocommunicative impairment in children with autism. This association suggests that strengths in nonsocial visuospatial processing may be related to the development of core autistic sociocommunicative impairments. Hum Brain Mapp 34:2524-2537, 2013. (c) 2012 Wiley Periodicals, Inc.
C1 [Keehn, Brandon; Shih, Patricia; Brenner, Laurie A.; Mueller, Ralph-Axel] San Diego State Univ, Dept Psychol, Brain Dev Imaging Lab, San Diego, CA 92182 USA.
[Keehn, Brandon] Univ Calif San Diego, San Diego State Univ, Joint Doctoral Program Language & Commun Disorder, San Diego, CA 92103 USA.
[Keehn, Brandon; Townsend, Jeanne] Univ Calif San Diego, Dept Neurosci, Res Aging & Dev Lab, San Diego, CA 92103 USA.
[Keehn, Brandon] Childrens Hosp, Div Dev Med, Labs Cognit Neurosci, Boston, MA 02115 USA.
RP Muller, RA (reprint author), San Diego State Univ, Dept Psychol, MC1863,6363 Alvarado Ct 200, San Diego, CA 92120 USA.
EM amueller@sciences.sdsu.edu
FU NIDCD [R01-DC006155, 1T32DC007361]; NIMH [R01-MH081023]
FX Contract grant sponsor: NIDCD; Contract grant number: R01-DC006155,
1T32DC007361 (author BK); Contract grant sponsor: NIMH; Contract grant
number: R01-MH081023.
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NR 64
TC 8
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD OCT
PY 2013
VL 34
IS 10
BP 2524
EP 2537
DI 10.1002/hbm.22084
PG 14
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 216TI
UT WOS:000324306900013
PM 22495745
ER
PT J
AU Tiwari, VN
Sundaram, SK
Chugani, HT
Huq, AHMM
AF Tiwari, Vijay N.
Sundaram, Senthil K.
Chugani, Harry T.
Huq, A. H. M. M.
TI Infantile Spasms Are Associated With Abnormal Copy Number Variations
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
DE epilepsy; CNV; copy number variation; infantile spasms
ID AUTISM-SPECTRUM DISORDERS; MENTAL-RETARDATION; TOURETTE SYNDROME;
DELETION SYNDROME; GENERALIST GENES; EPILEPSY; MUTATIONS; VARIANTS;
GENOME; REARRANGEMENTS
AB The authors tested the hypothesis that de novo copy number variations (CNVs) implicated in known genomic disorders ("pathogenic CNVs") are significant predisposing factors of infantile spasms. The authors performed a genome-wide analysis of single-nucleotide polymorphism genotyping microarray data to identify the role of de novo/known pathogenic large CNVs in 13 trios of children affected by infantile spasms. A rare, large (4.8 Mb) de novo duplication was detected in the 15q11-13 region of 1 patient. In addition, 3 known pathogenic CNVs (present in the patient as well as 1 of the parents) were detected in total. In 1 patient, a known pathogenic deletion was detected in the region of 2q32.3. Similarly, in 1 other patient, 2 known pathogenic deletions in the regions of 16p11.2 and Xp22.13 (containing CDKL5) were detected. These findings suggest that some specific pathogenic CNVs predispose to infantile spasms and may be associated with different phenotypes.
C1 [Tiwari, Vijay N.; Sundaram, Senthil K.; Chugani, Harry T.; Huq, A. H. M. M.] Wayne State Univ, Dept Pediat, Childrens Hosp Michigan, Detroit, MI 48202 USA.
[Tiwari, Vijay N.; Sundaram, Senthil K.; Chugani, Harry T.; Huq, A. H. M. M.] Wayne State Univ, Dept Neurol, Childrens Hosp Michigan, Detroit, MI 48202 USA.
[Tiwari, Vijay N.; Sundaram, Senthil K.; Chugani, Harry T.] Wayne State Univ, Positron Emiss Tomog Ctr, Childrens Hosp Michigan, Detroit, MI 48202 USA.
RP Huq, AHMM (reprint author), Childrens Hosp Michigan, Dept Neurol, 3901 Beaubien Blvd, Detroit, MI 48201 USA.
EM ahuq@med.wayne.edu
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NR 41
TC 4
Z9 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0883-0738
EI 1708-8283
J9 J CHILD NEUROL
JI J. Child Neurol.
PD OCT
PY 2013
VL 28
IS 10
BP 1191
EP 1196
DI 10.1177/0883073812453496
PG 6
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 217YM
UT WOS:000324399300001
PM 22914377
ER
PT J
AU Bauset, SM
Zazpe, I
Sanchis, AM
Gonzalez, AL
Suarez-Varela, MM
AF Mari Bauset, Salvador
Zazpe, Itziar
Mari Sanchis, Amelia
Llopis Gonzalez, Agustin
Morales Suarez-Varela, Maria
TI Are There Anthropometric Differences Between Autistic and Healthy
Children?
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
DE physical growth; anthropometric growth; body mass index; Spain; autism
spectrum disorders
ID BODY-MASS INDEX; PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS;
DIETARY INTERVENTION; FEMALE-CHILDREN; ADI-R; VALIDITY; WEIGHT; HEIGHT;
ADOS
AB Anthropometric development and growth were assessed in 2 groups of 6- to 9-year-olds: children with autism spectrum disorders and typically developing children. In a case-control study conducted in Valencia, Spain, we compared the body mass index (kg/m(2)) of 40 children with autism spectrum disorders (cases) and 113 typically developing children (controls) from the same area of residence. The sex- and age-adjusted odds ratios for being underweight in cases was 2.41 compared to controls. Furthermore, the body mass index distribution of the cases was significantly offset to lower values with respect to that of the controls (P = .024). In particular, 20% of the cases had a body mass index below the fifth percentile versus just 8.85% of the controls. Our data suggest that the anthropometric development of children with autism spectrum disorders should be monitored as part of routine care.
C1 [Mari Bauset, Salvador; Llopis Gonzalez, Agustin; Morales Suarez-Varela, Maria] Univ Valencia, Dept Prevent Med, Unit Publ Hlth & Environm Care, Valencia, Spain.
[Zazpe, Itziar] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
[Mari Sanchis, Amelia] Hosp Navarra, Sect Clin Nutr & Dietet, Navarra, Spain.
[Llopis Gonzalez, Agustin; Morales Suarez-Varela, Maria] CSISP, Valencia, Spain.
RP Suarez-Varela, MM (reprint author), Univ Valencia, Unit Publ Hlth & Environm Care, Dept Prevent Med, Avd Vicente Andres Estelles S-N, Burjassot Valencia 46100, Spain.
EM maria.m.morales@uv.es
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NR 34
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0883-0738
EI 1708-8283
J9 J CHILD NEUROL
JI J. Child Neurol.
PD OCT
PY 2013
VL 28
IS 10
BP 1226
EP 1232
DI 10.1177/0883073812458832
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 217YM
UT WOS:000324399300007
PM 23006495
ER
PT J
AU Rangasamy, S
D'Mello, SR
Narayanan, V
AF Rangasamy, Sampathkumar
D'Mello, Santosh R.
Narayanan, Vinodh
TI Epigenetics, Autism Spectrum, and Neurodevelopmental Disorders
SO NEUROTHERAPEUTICS
LA English
DT Review
DE Autism; Neurodevelopmental disorders; Rett; Prader-Willi; Angelman;
Fragile X; Methylation; Acetylation; Histones
ID FRAGILE-X-SYNDROME; PRADER-WILLI-SYNDROME; CPG-BINDING PROTEIN-2; MECP2
DUPLICATION SYNDROME; RETT-SYNDROME; DNA METHYLATION; KABUKI SYNDROME;
ANGELMAN-SYNDROME; MENTAL-RETARDATION; MOUSE MODEL
AB Epigenetic marks are modifications of DNA and histones. They are considered to be permanent within a single cell during development, and are heritable across cell division. Programming of neurons through epigenetic mechanisms is believed to be critical in neural development. Disruption or alteration in this process causes an array of neurodevelopmental disorders, including autism spectrum disorders (ASDs). Recent studies have provided evidence for an altered epigenetic landscape in ASDs and demonstrated the central role of epigenetic mechanisms in their pathogenesis. Many of the genes linked to the ASDs encode proteins that are involved in transcriptional regulation and chromatin remodeling. In this review we highlight selected neurodevelopmental disorders in which epigenetic dysregulation plays an important role. These include Rett syndrome, fragile X syndrome, Prader-Willi syndrome, Angelman syndrome, and Kabuki syndrome. For each of these disorders, we discuss how advances in our understanding of epigenetic mechanisms may lead to novel therapeutic approaches.
C1 [Rangasamy, Sampathkumar; Narayanan, Vinodh] Barrow Neurol Inst, Dev Neurogenet Lab, Phoenix, AZ 85013 USA.
[D'Mello, Santosh R.] Univ Texas Dallas, Richardson, TX 75083 USA.
RP Narayanan, V (reprint author), Barrow Neurol Inst, Dev Neurogenet Lab, Phoenix, AZ 85013 USA.
EM Vinodh.Narayanan@dignityhealth.org
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NR 158
TC 3
Z9 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1933-7213
EI 1878-7479
J9 NEUROTHERAPEUTICS
JI Neurotherapeutics
PD OCT
PY 2013
VL 10
IS 4
BP 742
EP 756
DI 10.1007/s13311-013-0227-0
PG 15
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 242WR
UT WOS:000326276300016
PM 24104594
ER
PT J
AU Pratt, L
Ni, L
Ponzio, NM
Jonakait, GM
AF Pratt, Lorelei
Ni, Li
Ponzio, Nicholas M.
Jonakait, G. Miller
TI Maternal inflammation promotes fetal microglial activation and increased
cholinergic expression in the fetal basal forebrain: role of
interleukin-6
SO PEDIATRIC RESEARCH
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; PRENATAL EXPOSURE; BRAIN-DEVELOPMENT;
IN-VITRO; INFECTION; DIFFERENTIATION; SCHIZOPHRENIA; CYTOKINES;
HIPPOCAMPUS; PLACENTA
AB BACKGROUND: Perinatal exposure to infectious agents with associated maternal immune activation (MIA) leads to neuroanatomical and behavioral dysregulation reminiscent of autism spectrum disorders. Persistent microglial activation as well as increased choline acetyltransferase (ChAT) activity in the basal forebrain (BF) are characteristic of autistic subjects. Previous studies have shown that medium from activated microglia promotes cholinergic differentiation of precursors in the BF. We sought to determine whether MIA in vivo would lead to a similar effect on developing BF neurons.
METHODS: Pregnant mice were treated with the viral mimic polyinosinic-polycytidylic acid (poly(l:C)) or saline.
RESULTS: Poly(1:C) treatment resulted in increased production of cytokines and chemokines in fetal microglia and increased ChAT activity and cholinergic cell number in the perinatal BE Whether microglial activation causes these changes is unclear. Examination of fetal brains from mice lacking interleukin-6 (IL-6 KOs) revealed an elevation in non-microglial-derived cytokines and chemokines over wild-type controls. Moreover, IL-6 KO offspring showed an elevation of ChAT activity even in the absence of poly(1:C) administration.
CONCLUSION: These data suggest that elevations in cytokines and/or chemokines caused either by maternal poly(I:C) administration or by the absence of IL-6 are associated with alterations in cholinergic development in the BE
C1 [Pratt, Lorelei] Rutgers State Univ, Dept Biol Sci, Newark, NJ 07102 USA.
[Ni, Li; Jonakait, G. Miller] New Jersey Inst Technol, Dept Biol Sci, Newark, NJ 07102 USA.
[Ponzio, Nicholas M.] Univ Med & Dent, New Jersey Med Sch, Dept Pathol & Lab Med, Newark, NJ USA.
RP Pratt, L (reprint author), Rutgers State Univ, Dept Biol Sci, Newark, NJ 07102 USA.
EM lpratt@andromeda.rutgers.edu
FU Autism Speaks; New Jersey Governor's Council for Medical Research and
Treatment of Autism
FX This work was supported by grants to G.M.J. and N.M.P. from Autism
Speaks and the New Jersey Governor's Council for Medical Research and
Treatment of Autism.
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NR 41
TC 3
Z9 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD OCT
PY 2013
VL 74
IS 4
BP 393
EP 401
DI 10.1038/pr.2013.126
PG 9
WC Pediatrics
SC Pediatrics
GA 239XT
UT WOS:000326060000005
PM 23877071
ER
PT J
AU Antshel, KM
Zhang-James, Y
Faraone, SV
AF Antshel, Kevin M.
Zhang-James, Yanli
Faraone, Stephen V.
TI The comorbidity of ADHD and autism spectrum disorder
SO EXPERT REVIEW OF NEUROTHERAPEUTICS
LA English
DT Review
DE ADHD; adolescent; ASD; autism spectrum; children; comorbidity;
developmental disorder
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT-HYPERACTIVITY
DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS; GENOME-WIDE ANALYSIS;
SYSTEMIC-LUPUS-ERYTHEMATOSUS; HIGH-FUNCTIONING AUTISM; PERINATAL
RISK-FACTORS; LOW-BIRTH-WEIGHT; PSYCHIATRIC-DISORDERS;
MOLECULAR-GENETICS
AB ADHD and autism spectrum disorder are common psychiatric comorbidities to each another. In addition, there is behavioral, biological and neuropsychological overlap between the two disorders. There are also several important differences between autism spectrum disorder and ADHD. Treatment strategies for the comorbid condition will also be reviewed. Future areas of research and clinical need will be discussed.
C1 [Antshel, Kevin M.] Syracuse Univ, Syracuse, NY 13244 USA.
[Zhang-James, Yanli; Faraone, Stephen V.] SUNY Upstate Med Univ, Syracuse, NY 13210 USA.
RP Antshel, KM (reprint author), Syracuse Univ, Syracuse, NY 13244 USA.
EM kmantshe@syr.edu
FU Akili Interactive Labs; VAYA Pharma; SynapDx; National Institutes of
Health; Shire; Alcobra; Otsuka; McNeil; Janssen; Novartis; Pfizer; Eli
Lilly
FX In the past year, SV Faraone has received consulting income and/or
research support from Akili Interactive Labs, VAYA Pharma and SynapDx,
and research support from the National Institutes of Health. SV
Faraone's institution is seeking a patent for the use of sodium-hydrogen
exchange inhibitors in the treatment of ADHD. In previous years, SV
Farone has received consulting fees or was on Advisory Boards or
participated in continuing medical education programs sponsored by
Shire, Alcobra, Otsuka, McNeil, Janssen, Novartis, Pfizer and Eli Lilly.
SV Faraone receives royalties from books published by Guilford Press
(Straight Talk about Your Child's Mental Health) and Oxford University
Press (Schizophrenia: The Facts). The authors have no other relevant
affiliations or financial involvement with any organization or entity
with a financial interest in or financial conflict with the subject
matter or materials discussed in the manuscript.
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NR 168
TC 7
Z9 7
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1473-7175
EI 1744-8360
J9 EXPERT REV NEUROTHER
JI Expert Rev. Neurother.
PD OCT
PY 2013
VL 13
IS 10
BP 1117
EP 1128
DI 10.1586/14737175.2013.840417
PG 12
WC Clinical Neurology; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 233EY
UT WOS:000325550300010
PM 24117274
ER
PT J
AU Smoller, JW
AF Smoller, Jordan W.
TI Disorders and Borders: Psychiatric Genetics and Nosology
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE psychiatric; genetic; nosology; pleiotropy; cross-disorder
ID POSTTRAUMATIC-STRESS-DISORDER; GENERALIZED ANXIETY DISORDER; AUTISM
SPECTRUM DISORDERS; ENVIRONMENTAL RISK-FACTORS; GENOME-WIDE ASSOCIATION;
CARDIO-FACIAL SYNDROME; POPULATION-BASED TWIN; DEFAULT MODE NETWORK;
DEFICIT HYPERACTIVITY DISORDER; SUPPORTED PSYCHOSIS VARIANT
AB Over the past century, the definition and classification of psychiatric disorders has evolved through a combination of historical trends, clinical observations, and empirical research. The current nosology, instantiated in the DSM-5 and ICD-10, rests on descriptive criteria agreed upon by a consensus of experts. While the development of explicit criteria has enhanced the reliability of diagnosis, the validity of the current diagnostic categories has been the subject of debate and controversy. Genetic studies have long been regarded as a key resource for validating the boundaries among diagnostic categories. Genetic epidemiologic studies have documented the familiality and heritability of clinically defined psychiatric disorders and molecular genetic studies have begun to identify specific susceptibility variants. At the same time, there is growing evidence from family, twin and genomic studies that genetic influences on psychiatric disorders transcend clinical boundaries. Here I review this evidence for cross-disorder genetic effects and discuss the implications of these findings for psychiatric nosology. Psychiatric genetic research can inform a bottom-up reappraisal of psychopathology that may help the field move beyond a purely descriptive classification and toward an etiology-based nosology. (c) 2013 Wiley Periodicals, Inc.
C1 [Smoller, Jordan W.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
[Smoller, Jordan W.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
RP Smoller, JW (reprint author), Simches Res Bldg,185 Cambridge St, Boston, MA 02114 USA.
EM jsmoller@hms.harvard.edu
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NR 283
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD OCT
PY 2013
VL 162
IS 7
SI SI
BP 559
EP 578
DI 10.1002/ajmg.b.32174
PG 20
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 238WN
UT WOS:000325982500002
PM 24132891
ER
PT J
AU Schreiber, M
Dorschner, M
Tsuang, D
AF Schreiber, Matthew
Dorschner, Michael
Tsuang, Debby
TI Next-Generation Sequencing in Schizophrenia and Other Neuropsychiatric
Disorders
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Review
DE schizophrenia; genetics; sequencing; whole exome; autism
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; CARDIO-FACIAL SYNDROME;
BIPOLAR DISORDER; MENTAL-RETARDATION; COMMON DISEASES; RARE VARIANTS;
RISK-FACTORS; GENETICS; ASSOCIATION
AB Schizophrenia is a debilitating lifelong illness that lacks a cure and poses a worldwide public health burden. The disease is characterized by a heterogeneous clinical and genetic presentation that complicates research efforts to identify causative genetic variations. This review examines the potential of current findings in schizophrenia and in other related neuropsychiatric disorders for application in next-generation technologies, particularly whole-exome sequencing (WES) and whole-genome sequencing (WGS). These approaches may lead to the discovery of underlying genetic factors for schizophrenia and may thereby identify and target novel therapeutic targets for this devastating disorder. (c) 2013 Wiley Periodicals, Inc.
C1 [Schreiber, Matthew; Dorschner, Michael; Tsuang, Debby] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Schreiber, Matthew] VAPSHCS, Mental Hlth Serv, Seattle, WA 98108 USA.
[Dorschner, Michael] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
[Dorschner, Michael; Tsuang, Debby] VAPSHCS, GRECC, Seattle, WA 98108 USA.
RP Tsuang, D (reprint author), VAPSHCS, GRECC, S-182 1660 S Columbian Way, Seattle, WA 98108 USA.
EM dwt1@uw.edu
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NR 72
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD OCT
PY 2013
VL 162
IS 7
SI SI
BP 671
EP 678
DI 10.1002/ajmg.b.32156
PG 8
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 238WN
UT WOS:000325982500011
PM 24132899
ER
PT J
AU Liao, HM
Gau, SSF
Tsai, WC
Fang, JS
Su, YC
Chou, MC
Liu, SK
Chou, WJ
Wu, YY
Chen, CH
AF Liao, Hsiao-Mei
Gau, Susan Shur-Fen
Tsai, Wen-Che
Fang, Jye-Siung
Su, Ying-Cheng
Chou, Miao-Chun
Liu, Shih-Kai
Chou, Wen-Jiun
Wu, Yu-Yu
Chen, Chia-Hsiang
TI Chromosomal Abnormalities in Patients With Autism Spectrum Disorders
From Taiwan
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE autism; genetics; chromosome; translocation; aneuploidy
ID KLINEFELTER-SYNDROME; PSYCHOMETRIC PROPERTIES; MENTAL-RETARDATION;
CHINESE VERSION; SEX-CHROMOSOMES; X-CHROMOSOME; XYY SYNDROME; GENES;
ASSOCIATION; CHILDREN
AB Autism spectrum disorders (ASD) are childhood-onset neurodevelopmental disorders characterized by verbal communication impairments, social reciprocity deficits, and the presence of restricted interests and stereotyped behaviors. Genetic factors contribute to the incidence of ASD evidently. However, the genetic spectrum of ASD is highly heterogeneous. Chromosomal abnormalities contribute significantly to the genetic deficits of syndromic and non-syndromic ASD. In this study, we conducted karyotyping analysis in a sample of 500 patients (447 males, 53 females) with ASD from Taiwan, the largest cohort in Asia, to the best of our knowledge. We found three patients having sex chromosome aneuploidy, including two cases of 47, XXY and one case of 47, XYY. In addition, we detected a novel reciprocal chromosomal translocation between long arms of chromosomes 4 and 14, designated t(4;14)(q31.3;q24.1), in a patient with Asperger's disorder. This translocation was inherited from his unaffected father, suggesting it might not be pathogenic or it needs further hits to become pathogenic. In line with other studies, our study revealed that subjects with sex chromosomal aneuploidy are liable to neurodevelopmental disorders, including ASD, and conventional karyotyping analysis is still a useful tool in detecting chromosomal translocation in patients with ASD, given that array-based comparative genomic hybridization technology can provide better resolution in detecting copy number variations of genomic DNA. (c) 2013 Wiley Periodicals, Inc.
C1 [Liao, Hsiao-Mei; Gau, Susan Shur-Fen; Tsai, Wen-Che; Chen, Chia-Hsiang] Natl Taiwan Univ, Coll Med, Dept Psychiat, Taipei 10764, Taiwan.
[Gau, Susan Shur-Fen; Tsai, Wen-Che] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei 10002, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Sch Grad Inst Brain & Mind Sci, Dept Psychol, Taipei 10764, Taiwan.
[Gau, Susan Shur-Fen] Natl Taiwan Univ, Grad Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan.
[Fang, Jye-Siung; Su, Ying-Cheng] Tzu Chi Univ, Dept Mol Biol & Human Genet, Hualien, Taiwan.
[Chou, Miao-Chun; Chou, Wen-Jiun] Kaohsiung Chang Gung Mem Hosp, Dept Child Psychiat, Tao Yuan, Taiwan.
[Chou, Miao-Chun; Chou, Wen-Jiun] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan.
[Liu, Shih-Kai] Taoyuan Mental Hosp, Dept Hlth, Dept Child & Adolescent Psychiat, Executive Yuan, Taiwan.
[Wu, Yu-Yu; Chen, Chia-Hsiang] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Psychiat,Linkou Med Ctr, Tao Yuan, Taiwan.
[Chen, Chia-Hsiang] Natl Hlth Res Inst, Ctr Neuropsychiat Res, Miaoli, Taiwan.
RP Gau, SSF (reprint author), Natl Taiwan Univ Hosp, Dept Psychiat, 7 Chung Shan S Rd, Taipei 10002, Taiwan.
EM gaushufe@ntu.edu.tw; cchen@nhri.org.tw
RI Ruan, YL/B-9813-2009
FU National Science Council [NSC96-3112-B-002-033, NSC97-3112-B-002-009,
NSC98-3112-B-002-004, NSC 99-3112-B-002-036]; National Taiwan University
(AIM for Top University Excellent Research Project) [10R81918-03,
101R892103, 102R892103]; National Health Research Institutes, Taiwan
FX Grant sponsor: National Science Council; Grant numbers:
NSC96-3112-B-002-033; NSC97-3112-B-002-009; NSC98-3112-B-002-004; NSC
99-3112-B-002-036; Grant sponsor: National Taiwan University (AIM for
Top University Excellent Research Project); Grant numbers: 10R81918-03;
101R892103; 102R892103; Grant sponsor: National Health Research
Institutes, Taiwan.
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NR 59
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD OCT
PY 2013
VL 162
IS 7
SI SI
BP 734
EP 741
DI 10.1002/ajmg.b.32153
PG 8
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 238WN
UT WOS:000325982500017
PM 24132905
ER
PT J
AU Chang, SC
Pauls, DL
Lange, C
Sasanfar, R
Santangelo, SL
AF Chang, Shun-Chiao
Pauls, David L.
Lange, Christoph
Sasanfar, Roksana
Santangelo, Susan L.
TI Sex-Specific Association of a Common Variant of the XG Gene With Autism
Spectrum Disorders
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE autism; GWAS; sex-specific; pseudoautosomal
ID HUMAN PSEUDOAUTOSOMAL REGIONS; GENOME-WIDE ASSOCIATION; RISK; LINKAGE;
CD99; SCHIZOPHRENIA; CHILDREN; ALLELES; LOCUS; BRAIN
AB Autism spectrum disorders (ASD) are much more common in males than in females. Studies using both linkage and candidate gene association approaches have identified genetic variants specific to families in which all affected cases were male, suggesting that sex may interact with or otherwise influence the expression of specific genes in association with ASD. In this study, we specifically evaluated the sex-specific genetic effects of ASD with a family-based genome-wide association study approach using the data from the Autism Genetic Resource Exchange repository. We evaluated the male-specific genetic effects of ASD in 374 multiplex families of European ancestry in which all affected were male (male-only; MO) and identified a novel genome-wide significant association in the pseudoautosomal boundary on chromosome Xp22.33/Yp11.31 in the MO families of predominantly paternal origin (rs2535443, p=3.8x10(-8)). Five markers that reside within a 550kb intergenic region on chromosome 13q33.3, between the MYO16 and IRS2 genes, also showed suggestive association with ASD in the MO families (p=3.3x10(-5) to 5.3x10(-7)). In contrast, none of these markers appeared to be associated with ASD in the families containing any affected females. Our results suggest that the pseudoautosomal boundary on Xp22.33/Yp11.31 may harbor male-specific genetic variants for ASD. (c) 2013 Wiley Periodicals, Inc.
C1 [Chang, Shun-Chiao; Pauls, David L.; Santangelo, Susan L.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Chang, Shun-Chiao] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
[Pauls, David L.; Sasanfar, Roksana; Santangelo, Susan L.] Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
[Pauls, David L.; Sasanfar, Roksana; Santangelo, Susan L.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
[Lange, Christoph] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
[Lange, Christoph] Brigham & Womens Hosp, Channing Labs, Boston, MA 02115 USA.
[Lange, Christoph] Harvard Univ, Sch Med, Boston, MA USA.
[Lange, Christoph] Univ Bonn, Inst Genom Math, Bonn, Germany.
[Lange, Christoph] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany.
[Santangelo, Susan L.] Maine Med Ctr, Res Inst, Dept Psychiat, Portland, ME 04102 USA.
RP Santangelo, SL (reprint author), Maine Med Ctr, 932 Congress St,Rm 224, Portland, ME 04102 USA.
EM SSantangel@mmc.org
FU AGRE Consortium; National Institute of Mental Health [1U24MH081810]
FX Grant sponsor: AGRE Consortium; Grant sponsor: National Institute of
Mental Health; Grant number: 1U24MH081810.
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NR 57
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD OCT
PY 2013
VL 162
IS 7
SI SI
BP 742
EP 750
DI 10.1002/ajmg.b.32165
PG 9
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA 238WN
UT WOS:000325982500018
PM 24132906
ER
PT J
AU Melchers, M
Montag, C
Markett, S
Reuter, M
AF Melchers, Martin
Montag, Christian
Markett, Sebastian
Reuter, Martin
TI Relationship Between Oxytocin Receptor Genotype and Recognition of
Facial Emotion
SO BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE emotion recognition; oxytocin; OXTR; perspective taking; empathy
ID UNDERSTANDING FACE RECOGNITION; SIGNAL-DETECTION ANALYSIS; AUTISM
SPECTRUM DISORDER; ASPERGER-SYNDROME; NEURAL SYSTEMS;
PERSPECTIVE-TAKING; SOCIAL COGNITION; HUMAN BRAIN; GENE OXTR;
EXPRESSIONS
AB The ability to understand thoughts and feelings of another person is an important prerequisite for successful social interaction. One part of this ability is the recognition of emotions in the face of the counterpart. Knowledge on genetic contributions to emotion recognition is still scarce. In the present study, 105 healthy participants were experimentally tested for their ability to recognize complex emotions in faces. As prior studies outlined the importance of the oxytocin system for emotion recognition, the functional rs2268498 polymorphism on the OXTR-gene was investigated. Although there were no differences in reaction times between genotype groups, carriers of the T-allele exhibited more accurate recognition skills than subjects carrying the CC-genotype. There was no influence of gender or age. Results support recent findings, demonstrating the importance of the oxytocin system for affect processing and related social behavior.
C1 [Melchers, Martin; Montag, Christian; Markett, Sebastian] Univ Bonn, Dept Psychol, D-53111 Bonn, Germany.
[Melchers, Martin; Montag, Christian; Markett, Sebastian] Univ Bonn, Neurogenet Lab, D-53111 Bonn, Germany.
[Reuter, Martin] Univ Bonn, Dept Psychol, Neurogenet Lab, D-53111 Bonn, Germany.
[Reuter, Martin] Univ Bonn, Ctr Econ & Neurosci, D-53111 Bonn, Germany.
RP Melchers, M (reprint author), Univ Bonn, Dept Psychol, Kaiser Karl Ring 9, D-53111 Bonn, Germany.
EM martin.melchers@uni-bonn-diff.de
FU DFG [RE 1692/4-1]
FX The study was financed by a DFG grant (RE 1692/4-1) awarded to Martin
Reuter.
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NR 96
TC 5
Z9 5
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0735-7044
EI 1939-0084
J9 BEHAV NEUROSCI
JI Behav. Neurosci.
PD OCT
PY 2013
VL 127
IS 5
BP 780
EP 787
DI 10.1037/a0033748
PG 8
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 236FH
UT WOS:000325780300020
PM 24128365
ER
PT J
AU Eger, E
Moretti, L
Dehaene, S
Sirigu, A
AF Eger, Evelyn
Moretti, Laura
Dehaene, Stanislas
Sirigu, Angela
TI Decoding the representation of learned social roles in the human brain
SO CORTEX
LA English
DT Article
DE Functional magnetic resonance imaging; Multivariate decoding; Face
processing; Social cognition; Learning
ID AUTISM SPECTRUM DISORDERS; ANTERIOR INSULA; PAIN; ACTIVATION; EXCLUSION;
REJECTION; RESPONSES; FACES; FMRI; JUDGMENTS
AB Humans as social beings are profoundly affected by exclusion. Short experiences with people differing in their degree of prosocial behaviour can induce reliable preferences for including partners, but the neural mechanisms of this learning remain unclear. Here, we asked participants to play a short social interaction game based on "cyber-ball" where one fictive partner included and another excluded the subject, thus defining social roles (includer - "good", excluder - "bad"). We then used multivariate pattern recognition on high-resolution functional magnetic resonance imaging (fMRI) data acquired before and after this game to test whether neural responses to the partners' and neutral control faces during a perceptual task reflect their learned social valence. Support vector classification scores revealed a learning-related increase in neural discrimination of social status in anterior insula and anterior cingulate regions, which was mainly driven by includer faces becoming distinguishable from excluder and control faces. Thus, face-evoked responses in anterior insula and anterior cing-ulate cortex contain fine-grained information shaped by prior social interactions that allow for categorisation of faces according to their learned social status. These lasting traces of social experience in cortical areas important for emotional and social processing could provide a substrate of how social inclusion shapes future behaviour and promotes cooperative interactions between individuals. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Eger, Evelyn; Dehaene, Stanislas] INSERM, U992, Gif Yuette, France.
[Eger, Evelyn; Dehaene, Stanislas] CEA, Gif Yuette, France.
[Eger, Evelyn; Dehaene, Stanislas] Univ Paris 11, Orsay, France.
[Moretti, Laura; Sirigu, Angela] CNRS, U5229, Bron, France.
[Dehaene, Stanislas] Coll France, F-75231 Paris, France.
RP Eger, E (reprint author), CEA Neurospin, INSERM, U992, Batiment 145,Point Courrier 156, F-91191 Gif Sur Yvette, France.
EM evelyn.eger@gmail.com
FU Centre National de le Recherche Scientific (CNRS); Fondation pour la
Recherche Medicale; Atomic Energy Commission
FX We thank Andreas Kleinschmidt for helpful comments on an earlier version
of this manuscript. This work was supported by Centre National de le
Recherche Scientific (CNRS) and Fondation pour la Recherche Medicale (AS
and LM). This. experiment was part of a general research program on
functional neuroimaging of the human brain which is sponsored by the
Atomic Energy Commission (Denis Le Bihan). We thank the NeuroSpin
platform staff for their help.
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NR 38
TC 1
Z9 1
PU ELSEVIER MASSON
PI MILANO
PA VIA PALEOCAPA 7, 20121 MILANO, ITALY
SN 0010-9452
EI 1973-8102
J9 CORTEX
JI Cortex
PD OCT
PY 2013
VL 49
IS 9
BP 2484
EP 2493
DI 10.1016/j.cortex.2013.02.008
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 239FS
UT WOS:000326008600018
PM 23528247
ER
PT J
AU Kover, ST
Pierpont, EI
Kim, JS
Brown, WT
Abbeduto, L
AF Kover, Sara T.
Pierpont, Elizabeth I.
Kim, Jee-Seon
Brown, W. Ted
Abbeduto, Leonard
TI A Neurodevelopmental Perspective on the Acquisition of Nonverbal
Cognitive Skills in Adolescents With Fragile X Syndrome
SO DEVELOPMENTAL NEUROPSYCHOLOGY
LA English
DT Article
ID DEVELOPMENTAL TRAJECTORIES; BEHAVIORAL DEVELOPMENT; FMRP LEVELS; YOUNG
BOYS; CHILDREN; AGE; DYSFUNCTION; DISORDERS; GIRLS; GENE
AB This longitudinal study was designed to investigate trajectories of nonverbal cognitive ability in adolescents with fragile X syndrome with respect to the relative influence of fragile X mental retardation protein (FMRP), autism symptom severity, and environmental factors on visualization and fluid reasoning abilities. Males and females with fragile X syndrome (N=53; ages 10-16 years) were evaluated with the Leiter-R at up to four annual assessments. On average, IQ declined with age. FMRP levels predicted change in fluid reasoning, but not in visualization. The role of FMRP in the neural development that underlies the fragile X syndrome cognitive phenotype is discussed.
C1 [Kover, Sara T.; Pierpont, Elizabeth I.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
[Kover, Sara T.] Univ Wisconsin, Dept Commun Sci & Disorders, Madison, WI 53705 USA.
[Pierpont, Elizabeth I.] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
[Kim, Jee-Seon] Univ Wisconsin, Dept Educ Psychol, Madison, WI 53705 USA.
[Brown, W. Ted] New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA.
[Abbeduto, Leonard] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
RP Kover, ST (reprint author), Univ Wisconsin, Waisman Ctr, 1500 Highland Ave,Room 475, Madison, WI 53705 USA.
EM kover@wisc.edu
FU NIH [R01 HD024356, P30 HD003352, F31 DC010959]
FX This research was supported by NIH grants R01 HD024356 and P30 HD003352
to Leonard Abbeduto and the Waisman Center, respectively, in addition to
NIH F31 DC010959 awarded to the first author.
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NR 38
TC 2
Z9 3
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 8756-5641
EI 1532-6942
J9 DEV NEUROPSYCHOL
JI Dev. Neuropsychol.
PD OCT 1
PY 2013
VL 38
IS 7
BP 445
EP 460
DI 10.1080/87565641.2013.820305
PG 16
WC Psychology, Developmental; Psychology; Psychology, Experimental
SC Psychology
GA 240BM
UT WOS:000326069700002
PM 24138215
ER
PT J
AU Mills, BD
Lai, JN
Brown, TT
Erhart, M
Halgren, E
Reilly, J
Appelbaum, M
Moses, P
AF Mills, Brian D.
Lai, Janie
Brown, Timothy T.
Erhart, Matthew
Halgren, Eric
Reilly, Judy
Appelbaum, Mark
Moses, Pamela
TI Gray Matter Structure and Morphosyntax Within a Spoken Narrative in
Typically Developing Children and Children With High Functioning Autism
SO DEVELOPMENTAL NEUROPSYCHOLOGY
LA English
DT Article
ID PROSPECTIVE MOTION CORRECTION; SURFACE-BASED ANALYSIS; HUMAN
CEREBRAL-CORTEX; CORTICAL THICKNESS; SPECTRUM DISORDER;
LANGUAGE-DEVELOPMENT; BRAIN VOLUME; MRI SCANS; SYSTEM; AGE
AB This study examined the relationship between magnetic resonance imaging (MRI)-based measures of gray matter structure and morphosyntax production in a spoken narrative in 17 typical children (TD) and 11 children with high functioning autism (HFA) between 6 and 13 years of age. In the TD group, cortical structure was related to narrative performance in the left inferior frontal gyrus (Broca's area), the right middle frontal sulcus, and the right inferior temporal sulcus. No associations were found in children with HFA. These findings suggest a systematic coupling between brain structure and spontaneous language in TD children and a disruption of these relationships in children with HFA.
C1 [Mills, Brian D.; Reilly, Judy; Moses, Pamela] San Diego State Univ, Dept Psychol, San Diego, CA 92120 USA.
[Lai, Janie; Reilly, Judy] San Diego State Univ, Sch Speech Hearing & Language Sci, San Diego, CA 92120 USA.
[Brown, Timothy T.] Univ Calif San Diego, Sch Med, Dept Neurosci, San Diego, CA 92103 USA.
[Brown, Timothy T.; Erhart, Matthew; Halgren, Eric] Univ Calif San Diego, Sch Med, Multimodal Imaging Lab, San Diego, CA 92103 USA.
[Halgren, Eric] Univ Calif San Diego, Sch Med, Dept Radiol, San Diego, CA 92103 USA.
[Reilly, Judy] Univ Poitiers, CNRS, Poitiers, France.
[Appelbaum, Mark] Univ Calif San Diego, Dept Psychol, San Diego, CA 92103 USA.
RP Moses, P (reprint author), San Diego State Univ, Dept Psychol, 6363 Alvarado Court,Suite 103, San Diego, CA 92120 USA.
EM pmoses@mail.sdsu.edu
FU NIH [NIH-NINDS 5 P50 NS22343]
FX This research was funded by NIH grant NIH-NINDS 5 P50 NS22343.
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NR 70
TC 0
Z9 0
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 8756-5641
EI 1532-6942
J9 DEV NEUROPSYCHOL
JI Dev. Neuropsychol.
PD OCT 1
PY 2013
VL 38
IS 7
BP 461
EP 480
DI 10.1080/87565641.2013.820306
PG 20
WC Psychology, Developmental; Psychology; Psychology, Experimental
SC Psychology
GA 240BM
UT WOS:000326069700003
PM 24138216
ER
PT J
AU Weems, CF
Scott, BG
Russell, JD
Reiss, AL
Carrion, VG
AF Weems, Carl F.
Scott, Brandon G.
Russell, Justin D.
Reiss, Allan L.
Carrion, Victor G.
TI Developmental Variation in Amygdala Volumes Among Children With
Posttraumatic Stress
SO DEVELOPMENTAL NEUROPSYCHOLOGY
LA English
DT Article
ID BRAIN-DEVELOPMENT; BIPOLAR DISORDER; PUBERTAL CHANGES; PTSD SYMPTOMS;
TEMPORAL-LOBE; HIPPOCAMPAL; ADOLESCENTS; AUTISM; YOUTH; MRI
AB This article examined associations between indices of maturation (age and Tanner stage) and amygdala volumes in 24 youth (aged 7-14) with posttraumatic stress disorder symptoms and a matched control group. Fifteen of the youth with exposure to trauma were also re-evaluated one year later. A positive association between maturation and right amygdala volumes was observed in the trauma group but not in controls. Associations with maturation remained when controlling for a number of possible covariates and over time. Developmentally younger youth (Tanner stage 1 and 2) showed increases and older (Tanner stage 3 and 4) decreases in right amygdala volumes.
C1 [Weems, Carl F.; Scott, Brandon G.; Russell, Justin D.] Univ New Orleans, Dept Psychol, New Orleans, LA 70148 USA.
[Reiss, Allan L.; Carrion, Victor G.] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
RP Weems, CF (reprint author), Univ New Orleans, Dept Psychol, New Orleans, LA 70148 USA.
EM cweems@uno.edu
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NR 44
TC 1
Z9 1
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 8756-5641
EI 1532-6942
J9 DEV NEUROPSYCHOL
JI Dev. Neuropsychol.
PD OCT 1
PY 2013
VL 38
IS 7
BP 481
EP 495
DI 10.1080/87565641.2013.820307
PG 15
WC Psychology, Developmental; Psychology; Psychology, Experimental
SC Psychology
GA 240BM
UT WOS:000326069700004
PM 24138217
ER
PT J
AU Pridding, A
AF Pridding, Andrew
TI Catatonia in autism
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Meeting Abstract
C1 [Pridding, Andrew] St Vincents Hosp Melbourne, Melbourne, Vic, Australia.
CR Taylor M, 2003, AM J PSYCHIAT, V160, P1
Wing L, 2000, BRIT J PSYCHIAT, V176, P357, DOI 10.1192/bjp.176.4.357
NR 2
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2013
VL 22
SU 1
SI SI
BP 28
EP 29
PG 2
WC Nursing; Psychiatry
SC Nursing; Psychiatry
GA 225XX
UT WOS:000324999600102
ER
PT J
AU de Bordes, PF
Cox, RFA
Hasselman, F
Cillessen, AHN
AF de Bordes, Pieter F.
Cox, Ralf F. A.
Hasselman, Fred
Cillessen, Antonius H. N.
TI Toddlers' gaze following through attention modulation: Intention is in
the eye of the beholder
SO JOURNAL OF EXPERIMENTAL CHILD PSYCHOLOGY
LA English
DT Article
DE Gaze following; Attention; Ostensive cues; Intention; CONSPEC; Natural
pedagogy
ID JOINT VISUAL-ATTENTION; INFANCY; AUTISM; CHILDREN; MECHANISMS;
INTERPRET; COGNITION; DIRECTION; CONTACT; LOOKING
AB We investigated 20-month-olds' (N = 56) gaze following by presenting toddlers with a female model that displayed either ostensive or no ostensive cues before shifting her gaze laterally toward an object. The results indicated that toddlers reliably followed the model's gaze redirection after mutual eye contact was established but did so equally reliably after the model's eyes had been made salient nonostensively. Moreover, both conditions elicited gaze following more prominently than when children's attention was initially directed away from the eyes either by specifically accentuating the mouth or by covering the entire face before the model redirected her eyes laterally. These findings suggest that gaze following by toddlers is more likely to be driven by general attention mechanisms than by their appreciation of somebody else's communicative intent through perceiving eye contact. (C) 2012 Elsevier Inc. All rights reserved.
C1 [de Bordes, Pieter F.] Univ Utrecht, Dept Special Educ, NL-3508 TC Utrecht, Netherlands.
[Cox, Ralf F. A.] Univ Groningen, Dept Dev Psychol, NL-9712 TS Groningen, Netherlands.
[Hasselman, Fred; Cillessen, Antonius H. N.] Radboud Univ Nijmegen, Inst Behav Sci, NL-6525 HR Nijmegen, Netherlands.
RP de Bordes, PF (reprint author), Univ Utrecht, Dept Special Educ, NL-3508 TC Utrecht, Netherlands.
EM p.f.debordes@uu.nl
RI Hasselman, Fred/C-5603-2011
OI Hasselman, Fred/0000-0003-1384-8361
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NR 50
TC 4
Z9 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-0965
EI 1096-0457
J9 J EXP CHILD PSYCHOL
JI J. Exp. Child Psychol.
PD OCT
PY 2013
VL 116
IS 2
SI SI
BP 443
EP 452
DI 10.1016/j.jecp.2012.09.008
PG 10
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA 233RJ
UT WOS:000325586900024
PM 23073365
ER
PT J
AU Gleichgerrcht, E
Torralva, T
Rattazzi, A
Marenco, V
Roca, M
Manes, F
AF Gleichgerrcht, Ezequiel
Torralva, Teresa
Rattazzi, Alexia
Marenco, Victoria
Roca, Maria
Manes, Facundo
TI Selective impairment of cognitive empathy for moral judgment in adults
with high functioning autism
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE utilitarianism; moral judgment; social cognition; emotion; Asperger
syndrome
ID VENTROMEDIAL PREFRONTAL CORTEX; SPECTRUM QUOTIENT AQ; ASPERGER-SYNDROME;
NEURAL BASIS; FRONTOTEMPORAL DEMENTIA; EMOTIONAL EMPATHY; MIND;
CHILDREN; DAMAGE; CHILDHOOD
AB Faced with a moral dilemma, conflict arises between a cognitive controlled response aimed at maximizing welfare, i.e. the utilitarian judgment, and an emotional aversion to harm, i.e. the deontological judgment. In the present study, we investigated moral judgment in adult individuals with high functioning autism/Asperger syndrome (HFA/AS), a clinical population characterized by impairments in prosocial emotions and social cognition. In Experiment 1, we compared the response patterns of HFA/AS participants and neurotypical controls to moral dilemmas with low and high emotional saliency. We found that HFA/AS participants more frequently delivered the utilitarian judgment. Their perception of appropriateness of moral transgression was similar to that of controls, but HFA/AS participants reported decreased levels of emotional reaction to the dilemma. In Experiment 2, we explored the way in which demographic, clinical and social cognition variables including emotional and cognitive aspects of empathy and theory of mind influenced moral judgment. We found that utilitarian HFA/AS participants showed a decreased ability to infer other people's thoughts and to understand their intentions, as measured both by performance on neuropsychological tests and through dispositional measures. We conclude that greater prevalence of utilitarianism in HFA/AS is associated with difficulties in specific aspects of social cognition.
C1 [Gleichgerrcht, Ezequiel; Torralva, Teresa; Rattazzi, Alexia; Marenco, Victoria; Roca, Maria; Manes, Facundo] Inst Cognit Neurol INECO, RA-1126 Buenos Aires, DF, Argentina.
[Gleichgerrcht, Ezequiel; Torralva, Teresa; Rattazzi, Alexia; Roca, Maria; Manes, Facundo] Favaloro Univ, Inst Neurosci, RA-1093 Buenos Aires, DF, Argentina.
[Gleichgerrcht, Ezequiel] Diego Portales Univ, Lab Neurosci, Santiago 8370179, Chile.
RP Gleichgerrcht, E (reprint author), INECO, Pacheco de Melo 1854, RA-1126 Buenos Aires, DF, Argentina.
EM egleich@ineco.org.ar
FU Fundacion INECO grant
FX Fundacion INECO grant.
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NR 88
TC 7
Z9 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD OCT
PY 2013
VL 8
IS 7
BP 780
EP 788
DI 10.1093/scan/nss067
PG 9
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA 236EV
UT WOS:000325778300007
PM 22689217
ER
PT J
AU Takeuchi, A
Ogino, T
Hanafusa, K
Morooka, T
Oka, M
Yorifuji, T
Ohtsuka, Y
AF Takeuchi, Akihito
Ogino, Tatsuya
Hanafusa, Kaoru
Morooka, Teruko
Oka, Makio
Yorifuji, Takashi
Ohtsuka, Yoko
TI Inhibitory Function and Working Memory in Attention
Deficit/Hyperactivity Disorder and Pervasive Developmental Disorders:
Does a Continuous Cognitive Gradient Explain ADHD and PDD Traits?
SO ACTA MEDICA OKAYAMA
LA English
DT Article
DE attention deficit/hyperactivity disorder; pervasive developmental
disorder; executive function; working memory; color-word matching Stroop
task
ID DEFICIT HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS;
SCHOOL-AGE-CHILDREN; EXECUTIVE FUNCTION; STROOP INTERFERENCE; SUSTAINED
ATTENTION; METAANALYSIS; PERFORMANCE; PROFILES; COLOR
AB To clarify the relationship between attention deficit/hyperactivity disorder (AD/HD) and pervasive developmental disorders (PDD), we investigated the common features and differences of these disorders in neuropsychological profiles. The subjects were 4 groups of Japanese boys aged 6 to 15 years, categorized by diagnosis: AD/HD (n = 20), PDD with comorbid AD/HD (PDD+ : n = 16), PDD without comorbid AD/HD (PDD-: n = 8), and typically developing (n = 60). We evaluated executive function (EF) through verbal and visuospatial memory tasks, the Go/NoGo task, and the color-word matching Stroop task. We performed a categorical analysis to estimate the effects of the 3 disorders on EF and a dimensional analysis to estimate the effects of symptom scales on EF. We found that the AD/HD and PDD+ subjects had negative effects on verbal working memory and infra-individual response variability. The severity of these impairments was positively correlated with the inattentiveness score. The subjects with a PDD+ or PDD- diagnosis had poorer scores on interference control; the severity of this impairment was correlated with the PDD symptom score. Impairments in visuospatial working memory were detected in the AD/HD and PDD- groups but not in the PDD+ group. Impairments in inhibition of the pre-potent response were noted in all 3 categories. AD/HD and PDD share neuropsychological features, though each disorder has a specific impairment pattern. Our findings partially support the idea that AD/HD and PDD are on a spectrum.
C1 [Takeuchi, Akihito; Hanafusa, Kaoru; Morooka, Teruko; Oka, Makio; Ohtsuka, Yoko] Okayama Univ, Dept Child Neurol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan.
[Ogino, Tatsuya] Chugokugakuen Univ, Fac Children Studies, Dept Children Studies, Okayama 7010153, Japan.
[Yorifuji, Takashi] Okayama Univ, Grad Sch Environm Sci, Dept Human Ecol, Okayama 7008530, Japan.
[Takeuchi, Akihito] Natl Hosp Org, Okayama Med Ctr, Dept Neonatol, Okayama 7011192, Japan.
RP Takeuchi, A (reprint author), Okayama Univ, Dept Child Neurol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan.
EM gmd18025@s.okayama-u.ac.jp
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NR 38
TC 2
Z9 2
PU OKAYAMA UNIV MED SCHOOL
PI OKAYAMA
PA EDITORIAL OFFICE, ACTA MEDICA OKAYAMA OKAYAMA UNIVERSITY MEDICAL SCHOOL
2-5-1 SHIKATA-CHO, KITA-KU, OKAYAMA, 700-8558, JAPAN
SN 0386-300X
J9 ACTA MED OKAYAMA
JI Acta Med. Okayama
PD OCT
PY 2013
VL 67
IS 5
BP 293
EP 303
PG 11
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 236YT
UT WOS:000325836100003
PM 24145729
ER
PT J
AU Breslin, CM
Rudisill, ME
AF Breslin, Casey M.
Rudisill, Mary E.
TI Relationships Among Assessment Time, Time on Task, and Motor Skill
Performance in Children With Autism Spectrum Disorder
SO ADAPTED PHYSICAL ACTIVITY QUARTERLY
LA English
DT Article
DE visual supports; Test of Gross Motor Development (Second Edition);
fundamental motor skills
ID ACTIVITY SCHEDULES
AB Twenty-two children (age range of 3.5-10.92 years old) with autism spectrum disorder (ASD) were assessed using the Test of Gross Motor Development (Second Edition; TGMD-2) using three different protocols. The total duration of assessment time and the percentage of time engaged in on-task behavior during the assessments were measured and analyzed using within-subjects repeated measure ANOVA designs to compare performance across the three protocols. Significant differences emerged across the duration of assessment time by assessment protocol, while no significant differences emerged for time on-task during the assessments by protocol used. In addition, correlations were calculated between the TGMD-2 scores and the duration of assessment time and the percentage of time on-task. An inverse relationship was found between TGMD-2 scores and total duration of assessment time by protocol used, (r = .726, .575, .686), while a positive relationship was found between the TGMD-2 scores and time on-task (r = -.570, -.535, -.798). These results suggest a direct relationship between skill proficiency and contextually appropriate behaviors.
C1 [Breslin, Casey M.] Temple Univ, Dept Kinesiol, Philadelphia, PA 19122 USA.
[Rudisill, Mary E.] Auburn Univ, Dept Kinesiol, Auburn, AL 36849 USA.
RP Breslin, CM (reprint author), Temple Univ, Dept Kinesiol, Philadelphia, PA 19122 USA.
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NR 24
TC 0
Z9 0
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0736-5829
EI 1543-2777
J9 ADAPT PHYS ACT Q
JI Adapt. Phys. Act. Q.
PD OCT
PY 2013
VL 30
IS 4
BP 338
EP 350
PG 13
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA 231VJ
UT WOS:000325446200003
PM 24197623
ER
PT J
AU McGrath, J
Johnson, K
O'Hanlon, E
Garavan, H
Gallagher, L
Leemans, A
AF McGrath, Jane
Johnson, Katherine
O'Hanlon, Erik
Garavan, Hugh
Gallagher, Louise
Leemans, Alexander
TI White Matter and Visuospatial Processing in Autism: A Constrained
Spherical Deconvolution Tractography Study
SO AUTISM RESEARCH
LA English
DT Article
DE diffusion MRI; constrained spherical deconvolution; tractography;
autism; visuospatial processing; inferior fronto-occipital fasciculus
ID TENSOR IMAGING TRACTOGRAPHY; HIGH-FUNCTIONING AUTISM; DIFFUSION-WEIGHTED
MRI; EMBEDDED FIGURES TASK; CORPUS-CALLOSUM; HUMAN BRAIN; CORTICAL
UNDERCONNECTIVITY; HEMISPHERIC ASYMMETRIES; SPECTRUM DISORDERS; ARCUATE
FASCICULUS
AB Autism spectrum disorders (ASDs) are associated with a marked disturbance of neural functional connectivity, which may arise from disrupted organization of white matter. The aim of this study was to use constrained spherical deconvolution (CSD)-based tractography to isolate and characterize major intrahemispheric white matter tracts that are important in visuospatial processing. CSD-based tractography avoids a number of critical confounds that are associated with diffusion tensor tractography, and to our knowledge, this is the first time that this advanced diffusion tractography method has been used in autism research. Twenty-five participants with ASD and aged 25, intelligence quotient-matched controls completed a high angular resolution diffusion imaging scan. The inferior fronto-occipital fasciculus (IFOF) and arcuate fasciculus were isolated using CSD-based tractography. Quantitative diffusion measures of white matter microstructural organization were compared between groups and associated with visuospatial processing performance. Significant alteration of white matter organization was present in the right IFOF in individuals with ASD. In addition, poorer visuospatial processing was associated in individuals with ASD with disrupted white matter in the right IFOF. Using a novel, advanced tractography method to isolate major intrahemispheric white matter tracts in autism, this research has demonstrated that there are significant alterations in the microstructural organization of white matter in the right IFOF in ASD. This alteration was associated with poorer visuospatial processing performance in the ASD group. This study provides an insight into structural brain abnormalities that may influence atypical visuospatial processing in autism. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [McGrath, Jane; Johnson, Katherine; Gallagher, Louise] St James Hosp, Dept Psychiat, Trinity Ctr Hlth Sci, Dublin 8, Ireland.
[Johnson, Katherine] Univ Melbourne, Parkville, Vic 3052, Australia.
[O'Hanlon, Erik] Beaumont Hosp, Royal Coll Surg Ireland, Dept Psychiat, Dublin 9, Ireland.
[Garavan, Hugh] Trinity Coll Dublin, Sch Psychol, Dublin, Ireland.
[Garavan, Hugh] Trinity Coll Dublin, Inst Neurosci, Dublin, Ireland.
[Garavan, Hugh] Univ Vermont, Dept Psychiat, Burlington, VT USA.
[Garavan, Hugh] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA.
[Leemans, Alexander] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands.
RP McGrath, J (reprint author), St James Hosp, Dept Psychiat, Trinity Ctr Hlth Sci, Dublin 8, Ireland.
EM jane.mcgrath@tcd.ie
RI Leemans, Alexander/A-1784-2011
FU Molecular Medicine Ireland [4AA-G04005-0-S06]
FX We wish to thank all the families who participated in this study, Mr.
Sean Brennan and Dr. Miriam Law-Smith for help with recruitment, and Dr.
Flavio Dell'Acqua, Dr. Marco Catani, Dr. Dara Cannon and Dr. Stephen
Meredith for expert advice on setting up the study. We gratefully
acknowledge the support of Molecular Medicine Ireland who funded this
work (grant number 4AA-G04005-0-S06), and thank Mr. Brendan Behan, Mr.
Sojo Joseph and many others for their invaluable assistance during the
study.
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NR 79
TC 6
Z9 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 307
EP 319
DI 10.1002/aur.1290
PG 13
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600001
PM 23509018
ER
PT J
AU Sterling, L
Munson, J
Estes, A
Murias, M
Webb, SJ
King, B
Dawson, G
AF Sterling, Lindsey
Munson, Jeffrey
Estes, Annette
Murias, Michael
Webb, Sara Jane
King, Bryan
Dawson, Geraldine
TI Fear-Potentiated Startle Response Is Unrelated to Social or Emotional
Functioning in Adolescents With Autism Spectrum Disorders
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorders; anxiety; startle response; amygdala
ID PERVASIVE DEVELOPMENTAL DISORDERS; CEREBRAL-BLOOD-FLOW; ANXIETY
DISORDERS; DIAGNOSTIC INTERVIEW; AMYGDALA DAMAGE; CHILDREN; SYMPTOMS;
MONKEYS; STIMULI; INDIVIDUALS
AB It has been suggested that atypical amygdala function contributes to the social impairments characteristic of autism spectrum disorders (ASDs). Previous research has demonstrated that adolescents and adults with ASD generate normal response during a fear-potentiated startle paradigm, suggesting this aspect of amygdala function is intact and may not account for the social dysfunction associated with the condition. The amygdala also plays a crucial role in the expression of anxiety and may contribute to high rates of reported anxiety in individuals with ASD. The present study partially replicates prior work by examining the fear-potentiated startle response in adolescents with ASD, and extends this to investigate the relationship between startle response and anxiety. Eyeblink magnitude and latency (electromyographic activity; EMG) were collected from 20 adolescents with ASD and 19 typically developing (TD) age-matched adolescents during a fear-potentiated startle paradigm. Parent-report and self-report of anxiety and additional psychiatric symptoms were collected. Parental reports indicated higher rates of associated psychopathology in adolescents with ASD compared with TD adolescents. Consistent with previous results, both groups showed normal potentiated startle response, and no group differences in EMG were found. Symptoms of anxiety and level of social impairment were unrelated to startle response. These findings held for all levels of anxiety, suggesting that within the context of the fear-potentiated startle paradigm, amygdala response is not associated with degree of atypical social or emotional functioning in ASD. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Sterling, Lindsey] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA.
[Munson, Jeffrey; Estes, Annette; Murias, Michael; Webb, Sara Jane; King, Bryan] Univ Washington, Ctr Child Dev & Disabil, Seattle, WA 98195 USA.
[Munson, Jeffrey; Murias, Michael; Webb, Sara Jane; King, Bryan] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Estes, Annette] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
[Dawson, Geraldine] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
[Dawson, Geraldine] Autism Speaks, New York, NY USA.
RP Sterling, L (reprint author), Univ Calif Los Angeles, Semel Inst, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza,48-257, Los Angeles, CA 90095 USA.
EM lsterling@mednet.ucla.edu
FU UW Autism Center of Excellence [P50 HD055782]; Autism Speaks Predoctoral
Fellowship (Sterling)
FX Funding for this project was provided by the UW Autism Center of
Excellence (P50 HD055782, King) and an Autism Speaks Predoctoral
Fellowship (Sterling).
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NR 78
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 320
EP 331
DI 10.1002/aur.1289
PG 12
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600002
PM 23495221
ER
PT J
AU Clark, AI
Hughes, PS
Grube, M
Stewart, ME
AF Clark, Andrea Irene
Hughes, Paul Shane
Grube, Manon
Stewart, Mary Elizabeth
TI Autistic Traits and Sensitivity to Interference With Flavour
Identification
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorder; autistic traits; personality; multisensory
perception; flavour perception
ID SPECTRUM DISORDERS; FUNCTIONING AUTISM; ASPERGER-SYNDROME; CHILDREN;
PERCEPTION; QUOTIENT; ADULTS; COLOR
AB We assessed whether autistic traits are related to the ability to identify flavour. In general, the colour of the food or drink facilitates identification of its flavour. In the current study, the colour of drinks either provided congruent, incongruent or ambiguous (colourless) information about the flavour. Participants identified the flavours of 12 drinks from a list and completed a measure of autistic traits, the Autism-Spectrum Quotient (AQ). In line with previous studies, flavour identification was impaired in incongruent conditions, while identification in congruent conditions was not improved when compared with that in ambiguous conditions. AQ scores were related to flavour identification in incongruent conditions, in that as the AQ score increased, accuracy of flavour identification decreased. There were no relationships found in the congruent or ambiguous conditions. This finding is in line with the idea that conflicting sensory information may be more disruptive for individuals on the autism spectrum. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Clark, Andrea Irene; Hughes, Paul Shane; Stewart, Mary Elizabeth] Heriot Watt Univ, Edinburgh EH14 4AS, Midlothian, Scotland.
[Grube, Manon] Newcastle Univ, Sch Med, Inst Neurosci, Auditory Grp, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
RP Stewart, ME (reprint author), Heriot Watt Univ, Edinburgh EH14 4AS, Midlothian, Scotland.
EM m.e.stewart@hw.ac.uk
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NR 21
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 332
EP 336
DI 10.1002/aur.1293
PG 5
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600003
PM 23576375
ER
PT J
AU Reynolds, S
Urruela, M
Devine, DP
AF Reynolds, Stacey
Urruela, Meagan
Devine, Darragh P.
TI Effects of Environmental Enrichment on Repetitive Behaviors in the BTBR
T plus tf/J Mouse Model of Autism
SO AUTISM RESEARCH
LA English
DT Article
DE autism; BTBR inbred strain; environmental enrichment; mouse model;
repetitive behavior; stereotypy
ID SPECTRUM DISORDERS; STEREOTYPED BEHAVIOR; MICE; CHILDREN; PHENOTYPES;
INTERESTS; RELEVANT; SYMPTOMS; DEFICITS; MEMORY
AB Lower order and higher order repetitive behaviors have been documented in the BTBR T+tf/J (BTBR) mouse strain, a mouse model that exhibits all three core behavioral domains that define autism. The purpose of this study was to evaluate the effectiveness of environmental enrichment for reducing repetitive behaviors in BTBR mice. Lower order behaviors were captured by assaying the time and sequence of grooming, while higher order behaviors were measured using pattern analysis of an object exploration task from digital recordings. Baseline scores were established at 7 weeks of age, followed by 30 days of housing in either a standard or enriched cage. As expected, BTBR mice spent significantly more time grooming and had a more rigid grooming sequence than control C57BL/6J mice did at baseline. After 30 days of enrichment housing, BTBR mice demonstrated a significant reduction in time spent grooming, resulting in levels that were lower than those exhibited by BTBR mice in standard housing. However, no changes were noted in the rigidity of their grooming sequence. In contrast to previous findings, there was no difference in repetitive patterns of exploration at baseline between BTBR and C57BL/6J mice in the object exploration test. Subsequently, enrichment did not significantly alter the number of repetitive patterns at posttest. Overall, the results suggest that environmental enrichment may be beneficial for reducing the time spent engaging in lower order repetitive behaviors, but may not change the overall quality of the behaviors when they do manifest. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Reynolds, Stacey] Virginia Commonwealth Univ, Richmond, VA 23298 USA.
[Urruela, Meagan; Devine, Darragh P.] Univ Florida, Gainesville, FL USA.
RP Reynolds, S (reprint author), Virginia Commonwealth Univ, Box 980008, Richmond, VA 23298 USA.
EM reynoldsse3@vcu.edu
FU National Center for Medical Rehabilitation Research; National Institute
of Neurological Disorders and Stroke, Rehabilitation Research Career
Development Program [K12 HD055929]
FX Grant Sponsor: National Center for Medical Rehabilitation Research and
the National Institute of Neurological Disorders and Stroke,
Rehabilitation Research Career Development Program.Grant Number: K12
HD055929.
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TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 337
EP 343
DI 10.1002/aur.1298
PG 7
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600004
PM 23813950
ER
PT J
AU Lukose, R
Brown, K
Barber, CM
Kulesza, RJ
AF Lukose, Richard
Brown, Kevin
Barber, Carol M.
Kulesza, Randy Joseph, Jr.
TI Quantification of the Stapedial Reflex Reveals Delayed Responses in
Autism
SO AUTISM RESEARCH
LA English
DT Article
DE autistic; auditory; superior olive; facial nucleus
ID BRAIN-STEM RESPONSES; CEREBELLAR PURKINJE-CELLS; TEST-RETEST
RELIABILITY; MESSENGER-RNA LEVELS; SPECTRUM DISORDERS; INFANTILE-AUTISM;
NEURONAL ORGANIZATION; MULTIPLE-SCLEROSIS; SUPERIOR OLIVE; MUSCLE-REFLEX
AB Autism is a developmental disorder characterized, in part, by sensory abnormalities. It is well established that most if not all patients with autism have problems with auditory processing, ranging from deafness to hyperacusis, and physiological testing of auditory function (i.e. auditory brain stem responses) implicates brain stem dysfunction in autism. Additionally, previous research from this lab has revealed significantly fewer auditory brain stem neurons in autistic subjects as young as 2 years of age. These observations have led us to hypothesize that objective, noninvasive measures of auditory function can be used as an early screening tool to identify neonates with an elevated risk of carrying a diagnosis of autism. Here, we provide a detailed quantitative investigation of the acoustic stapedial reflex (ASR), a three- or four-neuron brain stem circuit, in young autistic subjects and normal developing controls. Indeed, we find significantly lower thresholds, responses occurring at significantly longer latency and right-left asymmetry in autistic subjects. The results from this investigation support deficits in auditory function as a cardinal feature of autism and suggest that individuals with autism can be identified by their ASR responses. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Lukose, Richard] Univ Pittsburgh, Dept Neurol, Med Ctr Hamot, Erie, PA USA.
[Brown, Kevin; Kulesza, Randy Joseph, Jr.] Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA 16509 USA.
[Barber, Carol M.] Carolina Pediat Therapy, Asheville, NC USA.
RP Kulesza, RJ (reprint author), Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA 16509 USA.
EM rkulesza@lecom.edu
FU Lake Erie Consortium of Osteopathic Medical Training
FX Grant sponsor: Lake Erie Consortium of Osteopathic Medical Training.
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NR 82
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 344
EP 353
DI 10.1002/aur.1297
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600005
PM 23825093
ER
PT J
AU Griesi-Oliveira, K
Sunaga, DY
Alvizi, L
Vadasz, E
Passos-Bueno, MR
AF Griesi-Oliveira, Karina
Sunaga, Daniele Yumi
Alvizi, Lucas
Vadasz, Estevao
Passos-Bueno, Maria Rita
TI Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems
in Autism Spectrum Disorders
SO AUTISM RESEARCH
LA English
DT Article
DE expression studies; androgen signaling; CHD8; stem cells of human
exfoliated deciduous teeth
ID DE-NOVO MUTATIONS; COPY NUMBER VARIANTS; EXPRESSION; GENES; LINES;
GENETICS; POWERFUL; CHILDREN; PATHWAYS; BRAIN
AB Identification of the causes of autism spectrum disorders (ASDs) is hampered by their genetic heterogeneity; however, the different genetic alterations leading to ASD seem to be implicated in the disturbance of common molecular pathways or biological processes. In this scenario, the search for differentially expressed genes (DEGs) between ASD patients and controls is a good alternative to identify the molecular etiology of such disorders. Here, we employed genome-wide expression analysis to compare the transcriptome of stem cells of human exfoliated deciduous teeth (SHEDs) of idiopathic autistic patients (n=7) and control samples (n=6). Nearly half of the 683 identified DEGs are expressed in the brain (P=0.003), and a significant number of them are involved in mechanisms previously associated with ASD such as protein synthesis, cytoskeleton regulation, cellular adhesion and alternative splicing, which validate the use of SHEDs to disentangle the causes of autism. Autistic patients also presented overexpression of genes regulated by androgen receptor (AR), and AR itself, which in turn interacts with CHD8 (chromodomain helicase DNA binding protein 8), a gene recently shown to be associated with the cause of autism and found to be upregulated in some patients tested here. These data provide a rationale for the mechanisms through which CHD8 leads to these diseases. In summary, our results suggest that ASD share deregulated pathways and revealed that SHEDs represent an alternative cell source to be used in the understanding of the biological mechanisms involved in the etiology of ASD. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Griesi-Oliveira, Karina; Sunaga, Daniele Yumi; Alvizi, Lucas; Passos-Bueno, Maria Rita] Univ Sao Paulo, Ctr Estudos Genoma Humano, Dept Biol, Inst Biociencias, BR-05508090 Sao Paulo, Brazil.
[Vadasz, Estevao] Univ Sao Paulo, Fac Med, Inst Psiquiatria, Hosp Clin, BR-05508090 Sao Paulo, Brazil.
RP Passos-Bueno, MR (reprint author), Univ Sao Paulo, Inst Biociencias, Rua Matao,277,Sala 200, BR-05508090 Sao Paulo, Brazil.
EM passos@ib.usp.br
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
nacional de desenvolvimento cientifico e tecnologico (CNPq)
FX This study was supported by Fundacao de Amparo a Pesquisa do Estado de
Sao Paulo (FAPESP) and Conselho nacional de desenvolvimento cientifico e
tecnologico (CNPq). We would like to thank Daniela Franco Bueno and
Gerson Shigeru Kobayshi for the control microarray data.
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NR 54
TC 5
Z9 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 354
EP 361
DI 10.1002/aur.1296
PG 8
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600006
PM 23801657
ER
PT J
AU Scheeren, AM
Koot, HM
Mundy, PC
Mous, L
Begeer, S
AF Scheeren, Anke M.
Koot, Hans M.
Mundy, Peter C.
Mous, Larissa
Begeer, Sander
TI Empathic Responsiveness of Children and Adolescents with
High-Functioning Autism Spectrum Disorder
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorder; empathy; emotional response; social
interaction
ID YOUNG-CHILDREN; RESPONSES; DISTRESS; OTHERS; COGNITION; EMOTIONS;
CONTEXT; RISK
AB Previous studies have shown reduced empathic responsiveness to others' emotions in preschoolers with autism spectrum disorder (ASD) and an intellectual disability. However, age and intelligence may promote children's empathic responsiveness. Therefore, we examined the empathic responsiveness in normally intelligent school-aged children and adolescents with a clinical diagnosis of ASD (n=151) and in a typically developing comparison group (n=50), using structured observations and parent reports. Based on the observations, participants' responses to the emotional displays of an interviewer were surprisingly similar. However, compared with parents from the comparison group, parents of a child with ASD reported significantly fewer empathic responses, particularly when the child received a high score on the Autism Diagnostic Observation Schedule. Even though parents report a reduced empathic responsiveness in school-aged children and adolescents with ASD, it may be difficult to find these empathic limitations during brief observations in a structured setting. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Scheeren, Anke M.; Koot, Hans M.; Mous, Larissa; Begeer, Sander] Vrije Univ Amsterdam, NL-1081 BT Amsterdam, Netherlands.
[Scheeren, Anke M.; Koot, Hans M.; Mous, Larissa; Begeer, Sander] Autism Res Amsterdam, Amsterdam, Netherlands.
[Mundy, Peter C.] Univ Calif Davis, Sch Educ, MIND Inst, Davis, CA 95616 USA.
[Begeer, Sander] Univ Sydney, Sydney, NSW 2006, Australia.
RP Scheeren, AM (reprint author), Vrije Univ Amsterdam, Dept Dev Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
EM a.m.scheeren@vu.nl
FU Stichting Nuts Ohra [SNO-T-0701-116]
FX Grant sponsor: Stichting Nuts Ohra.Grant number: SNO-T-0701-116.
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NR 41
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 362
EP 371
DI 10.1002/aur.1299
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600007
PM 24039228
ER
PT J
AU van Santen, JPH
Sproat, RW
Hill, AP
AF van Santen, Jan P. H.
Sproat, Richard W.
Hill, Alison Presmanes
TI Quantifying Repetitive Speech in Autism Spectrum Disorders and Language
Impairment
SO AUTISM RESEARCH
LA English
DT Article
DE autism spectrum disorder; specific language impairment; echolalia;
repetitive behavior
ID DIAGNOSTIC OBSERVATION SCHEDULE; FRAGILE-X-SYNDROME; IMMEDIATE
ECHOLALIA; MENTAL-RETARDATION; YOUNG-CHILDREN; DOWN-SYNDROME; FIELD
TRIAL; STEREOTYPY; INTERVIEW; BEHAVIOR
AB We report on an automatic technique for quantifying two types of repetitive speech: repetitions of what the child says him/herself (self-repeats) and of what is uttered by an interlocutor (echolalia). We apply this technique to a sample of 111 children between the ages of four and eight: 42 typically developing children (TD), 19 children with specific language impairment (SLI), 25 children with autism spectrum disorders (ASD) plus language impairment (ALI), and 25 children with ASD with normal, non-impaired language (ALN). The results indicate robust differences in echolalia between the TD and ASD groups as a whole (ALN+ALI), and between TD and ALN children. There were no significant differences between ALI and SLI children for echolalia or self-repetitions. The results confirm previous findings that children with ASD repeat the language of others more than other populations of children. On the other hand, self-repetition does not appear to be significantly more frequent in ASD, nor does it matter whether the child's echolalia occurred within one (immediate) or two turns (near-immediate) of the adult's original utterance. Furthermore, non-significant differences between ALN and SLI, between TD and SLI, and between ALI and TD are suggestive that echolalia may not be specific to ALN or to ASD in general. One important innovation of this work is an objective fully automatic technique for assessing the amount of repetition in a transcript of a child's utterances. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [van Santen, Jan P. H.; Hill, Alison Presmanes] Oregon Hlth & Sci Univ, Ctr Spoken Language Understanding, Beaverton, OR 97006 USA.
[Sproat, Richard W.] Google New York, New York, NY USA.
RP van Santen, JPH (reprint author), Oregon Hlth & Sci Univ, Ctr Spoken Language Understanding, 20000 NW Walker Rd, Beaverton, OR 97006 USA.
EM janphvansanten@gmail.com
FU National Institute on Deafness and Other Communication Disorders
[R01DC012033, R01DC007129-01]; Autism Speaks [2407]
FX Grant sponsor: National Institute on Deafness and Other Communication
Disorders; Grant numbers: R01DC012033, R01DC007129-01.Grant sponsor:
Autism Speaks; Grant number: Innovative Technology for Autism Grant
2407.
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NR 50
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 372
EP 383
DI 10.1002/aur.1301
PG 12
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600008
PM 23661504
ER
PT J
AU Pu, DH
Shen, YP
Wu, J
AF Pu, Danhua
Shen, Yiping
Wu, Jie
TI Association between MTHFR Gene Polymorphisms and the Risk of Autism
Spectrum Disorders: A Meta-Analysis
SO AUTISM RESEARCH
LA English
DT Article
DE methylenetetrahydrofolate reductase; polymorphism; autism spectrum
disorders; folic acid; meta-analysis
ID CHINESE HAN POPULATION; METHYLENETETRAHYDROFOLATE REDUCTASE; OXIDATIVE
STRESS; CHILDREN; PREGNANCY; SELECTION; C677T; TWIN
AB Methylenetetrahydrofolate reductase (MTHFR) is essential for DNA biosynthesis and the epigenetic process of DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth defects, neurological disorders, and cancers. However, reports on the association of MTHFR polymorphisms with autism spectrum disorders (ASD) are inconclusive. Therefore, we investigated the relationship of the MTHFR polymorphisms (C677T and A1298C) and the risk of ASD by meta-analysis. Up to December 2012, eight case-control studies involving 1672 patients with ASD and 6760 controls were included for meta-analysis. The results showed that the C677T polymorphism was associated with significantly increased ASD risk in all the comparison models [T vs. C allele (frequency of allele): odds ratio (OR)=1.42, 95% confidence interval (CI): 1.09-1.85; CT vs. CC (heterozygote): OR=1.48, 95% CI: 1.09-2.00; TT vs. CC (homozygote): OR=1.86, 95% CI: 1.08-3.20; CT+TT vs. CC (dominant model): OR=1.56, 95% CI: 1.12-2.18; and TT vs. CC+CT (recessive model): OR=1.51, 95% CI: 1.02-2.22], whereas the A1298C polymorphism was found to be significantly associated with reduced ASD risk but only in a recessive model (CC vs. AA+AC: OR=0.73, 95% CI: 0.56-0.97). In addition, we stratified the patient population based on whether they were from a country with food fortification of folic acid or not. The meta-analysis showed that the C677T polymorphism was found to be associated with ASD only in children from countries without food fortification. Our study indicated that the MTHFR C677T polymorphism contributes to increased ASD risk, and periconceptional folic acid may reduce ASD risk in those with MTHFR 677C>T polymorphism. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Pu, Danhua; Wu, Jie] Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China.
[Pu, Danhua; Wu, Jie] Nanjing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Nanjing 210029, Jiangsu, Peoples R China.
[Shen, Yiping] Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Shanghai 200030, Peoples R China.
[Shen, Yiping] Boston Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA.
[Shen, Yiping] Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA.
[Shen, Yiping] Harvard Univ, Sch Med, Boston, MA 02115 USA.
RP Wu, J (reprint author), Nanjing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM Yiping.Shen@childrens.harvard.edu; jie.wuyale@gmail.com
FU Priority Academic Program Development of Jiangsu Higher Education
Institutions
FX Grant sponsor: A Project Funded by the Priority Academic Program
Development of Jiangsu Higher Education Institutions.
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NR 32
TC 5
Z9 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 384
EP 392
DI 10.1002/aur.1300
PG 9
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600009
PM 23653228
ER
PT J
AU Jarrold, W
Mundy, P
Gwaltney, M
Bailenson, J
Hatt, N
McIntyre, N
Kim, K
Solomon, M
Novotny, S
Swain, L
AF Jarrold, William
Mundy, Peter
Gwaltney, Mary
Bailenson, Jeremy
Hatt, Naomi
McIntyre, Nancy
Kim, Kwanguk
Solomon, Marjorie
Novotny, Stephanie
Swain, Lindsay
TI Social Attention in a Virtual Public Speaking Task in Higher Functioning
Children With Autism
SO AUTISM RESEARCH
LA English
DT Article
DE cognition and learning; school-aged development; social attention;
individual differences
ID PERVASIVE DEVELOPMENTAL DISORDERS; COGNITIVE-BEHAVIORAL THERAPY; JOINT
ATTENTION; SPECTRUM DISORDERS; SCREENING QUESTIONNAIRE; EXECUTIVE
FUNCTION; DEFICIT/HYPERACTIVITY DISORDER; ASPERGER-SYNDROME; TOTAL
POPULATION; ANXIETY
AB Impairments in social attention play a major role in autism, but little is known about their role in development after preschool. In this study, a public speaking task was used to study social attention, its moderators, and its association with classroom learning in elementary and secondary students with higher functioning autism spectrum disorder (HFASD). Thirty-seven students with HFASD and 54 age- and intelligence quotient (IQ)-matched peers without symptoms of ASD were assessed in a virtual classroom public speaking paradigm. This paradigm assessed the ability to attend to nine avatar peers seated at a table, while simultaneously answering self-referenced questions. Students with HFASD looked less frequently to avatar peers in the classroom while talking. However, social attention was moderated in the HFASD sample such that students with lower IQ, and/or more symptoms of social anxiety, and/or more attention deficit/hyperactivity disorder inattentive symptoms, displayed more atypical social attention. Group differences were more pronounced when the classroom contained social avatars versus nonsocial targets. Moreover, measures of social attention rather than nonsocial attention were significantly associated with parent report and objective measures of learning in the classroom. The data in this study support the hypothesis of the Social Attention Model of ASD that social attention disturbance remains part of the school-aged phenotype of autism that is related to syndrome-specific problems in social learning. More research of this kind would likely contribute to advances in the understanding of the development of the spectrum of autism and educational intervention approaches for affected school-aged children. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Jarrold, William; Mundy, Peter; Kim, Kwanguk; Solomon, Marjorie] Univ Calif Davis, Dept Psychiat, MIND Inst, Sacramento, CA USA.
[Mundy, Peter; Gwaltney, Mary; McIntyre, Nancy; Swain, Lindsay] Univ Calif Davis, Sch Educ, Davis, CA USA.
[Mundy, Peter] Univ Calif Davis, Ctr Mind & Brain, Davis, CA USA.
[Bailenson, Jeremy] Stanford Univ, Dept Commun Sci, Palo Alto, CA 94304 USA.
[Hatt, Naomi] Univ Calif Davis, Dept Psychol, Davis, CA USA.
[Novotny, Stephanie] Univ Calif Davis, Sacramento, CA USA.
RP Mundy, P (reprint author), UC Davis Sch Educ, 1 Shields Ave, Davis, CA 95616 USA.
EM pcmundy@ucdavis.edu
FU NIH [1R21MH085904]; IES [R324A120168]; UC Davis Center for Mind and
Brain; UC Davis Lisa Capps Endowment for Research on Neurodevelopmental
Disorders and Education
FX This research would not have been possible without support from NIH
grant 1R21MH085904, IES Grant R324A120168, the UC Davis Center for Mind
and Brain, and the UC Davis Lisa Capps Endowment for Research on
Neurodevelopmental Disorders and Education. We would also like to thank
Sally Ozonoff (UC Davis) and Thomas Parsons (USC) for their instrumental
consultation on this research.
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NR 75
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 393
EP 410
DI 10.1002/aur.1302
PG 18
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600010
PM 23696132
ER
PT J
AU Berger, NI
Ingersoll, B
AF Berger, Natalie I.
Ingersoll, Brooke
TI An Exploration of Imitation Recognition in Young Children With Autism
Spectrum Disorders
SO AUTISM RESEARCH
LA English
DT Article
DE autism; imitation; imitation recognition; social cognition
ID COMMUNICATION DEFICITS; SOCIAL COGNITION
AB The ability to recognize when one is being imitated has been hypothesized to be an important developmental process related to the emergence of more advanced social-cognitive skills. While a series of behaviors indicating progressively more mature imitation recognition (IR) skills has been assessed in typically developing children, empirical work with children with autism spectrum disorders (ASDs) has largely focused on basic social responses to an imitative adult (e.g. increases in eye contact). Limited work has explored more mature IR behaviors in this population. This study compared the degree to which children with ASD engage in different behaviors thought to be indicative of IR during a naturalistic imitation task and the relationship between different types of IR behaviors and social-cognitive skills (i.e. imitation, language, social reciprocity, and joint attention). Thirty children with ASD were administered standardized measures of cognitive level, language, joint attention, social reciprocity, and imitation. IR behaviors were observed during periods of contingent imitation by an adult. Participants engaged more frequently in less mature (e.g. looking at the experimenter's toy or face) than more mature IR behaviors (e.g. testing the experimenter's intent to imitate). After controlling for developmental level, social reciprocity, object imitation, and gesture imitation were positively correlated with more mature IR. These findings suggest that the development of more mature IR skills is related to the development of other social-cognitive skills in children with ASD and provide additional empirical support for reports of more mature IR observed in this population. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Berger, Natalie I.; Ingersoll, Brooke] Michigan State Univ, E Lansing, MI 48824 USA.
RP Berger, NI (reprint author), Michigan State Univ, Dept Psychol, 316 Phys Rd,Room 69F, E Lansing, MI 48824 USA.
EM bergerna@msu.edu
RI Ingersoll, Brooke/A-9117-2012
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NR 30
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 411
EP 416
DI 10.1002/aur.1303
PG 6
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600011
PM 23696180
ER
PT J
AU Venker, CE
Eernisse, ER
Saffran, JR
Weismer, SE
AF Venker, Courtney E.
Eernisse, Elizabeth R.
Saffran, Jenny R.
Weismer, Susan Ellis
TI Individual Differences in the Real-Time Comprehension of Children with
ASD
SO AUTISM RESEARCH
LA English
DT Article
DE autism; comprehension; language processing; receptive vocabulary;
eye-gaze methodology; individual differences
ID AUTISM SPECTRUM DISORDERS; SPOKEN WORD RECOGNITION; LATE-TALKING
TODDLERS; AGE-OF-ACQUISITION; LANGUAGE-ACQUISITION; YOUNG-CHILDREN;
PRESCHOOL-CHILDREN; VOCABULARY GROWTH; JOINT ATTENTION; IMPAIRMENT
AB Many children with autism spectrum disorders (ASD) demonstrate deficits in language comprehension, but little is known about how they process spoken language as it unfolds. Real-time lexical comprehension is associated with language and cognition in children without ASD, suggesting that this may also be the case for children with ASD. This study adopted an individual differences approach to characterizing real-time comprehension of familiar words in a group of 34 three- to six-year-olds with ASD. The looking-while-listening paradigm was employed; it measures online accuracy and latency through language-mediated eye movements and has limited task demands. On average, children demonstrated comprehension of the familiar words, but considerable variability emerged. Children with better accuracy were faster to process the familiar words. In combination, processing speed and comprehension on a standardized language assessment explained 63% of the variance in online accuracy. Online accuracy was not correlated with autism severity or maternal education, and nonverbal cognition did not explain unique variance. Notably, online accuracy at age 51/2 was related to vocabulary comprehension 3 years earlier. The words typically learned earliest in life were processed most quickly. Consistent with a dimensional view of language abilities, these findings point to similarities in patterns of language acquisition in typically developing children and those with ASD. Overall, our results emphasize the value of examining individual differences in real-time language comprehension in this population. We propose that the looking-while-listening paradigm is a sensitive and valuable methodological tool that can be applied across many areas of autism research. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Venker, Courtney E.; Eernisse, Elizabeth R.; Saffran, Jenny R.; Weismer, Susan Ellis] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
RP Venker, CE (reprint author), Univ Wisconsin, Waisman Ctr, 1500 Highland Ave Room 475, Madison, WI 53705 USA.
EM cgerickson@wisc.edu
FU National Institute on Deafness & Other Communication Disorders
[R01DC007223, T32DC005359, F31DC009142]; National Institute of Child
Health & Human Development [R37HD037466, P30HD003352]
FX First and foremost, we would like to thank the children and families who
participated in this study. We appreciate their generosity and their
commitment to this research. We would also like to thank Anna Dorrance,
Taryn Stricker, and Meghan Davidson for their assistance with eye-gaze
coding. Thanks also to Chris Potter, Casey Lew-Williams, Sara Kover,
Brianna McMillan, and Erica Wojcik for helpful discussions about the
looking-while-listening paradigm. Funding for this study was provided by
the National Institute on Deafness & Other Communication Disorders
(R01DC007223, T32DC005359, F31DC009142) and the National Institute of
Child Health & Human Development (R37HD037466, P30HD003352).
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Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 48
TC 6
Z9 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 417
EP 432
DI 10.1002/aur.1304
PG 16
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600012
PM 23696214
ER
PT J
AU Cage, E
Pellicano, E
Shah, P
Bird, G
AF Cage, Eilidh
Pellicano, Elizabeth
Shah, Punit
Bird, Geoffrey
TI Reputation Management: Evidence for Ability But Reduced Propensity in
Autism
SO AUTISM RESEARCH
LA English
DT Article
DE reputation management; theory of mind; reward; reciprocity; autism
ID SPECTRUM DISORDER; SELF-PRESENTATION; ASPERGER-SYNDROME; SOCIAL
COGNITION; MIND; CHILDREN; REWARD; COOPERATION; RECIPROCITY; GENEROSITY
AB Previous research has reported that autistic adults do not manage their reputation, purportedly due to problems with theory of mind [Izuma, Matsumoto, Camerer, & Adolphs]. The current study aimed to test alternative explanations for this apparent lack of reputation management. Twenty typical and 19 autistic adults donated to charity and to a person, both when alone and when observed. In an additional manipulation, for half of the participants, the observer was also the recipient of their donations, and participants were told that this observer would subsequently have the opportunity to donate to them (motivation condition). This manipulation was designed to encourage an expectation of a reciprocal tit-for-tat strategy in the participant, which may motivate participants to change their behavior to receive more donations. The remaining participants were told that the person watching was just observing the procedure (no motivation condition). Our results replicated Izuma etal.'s finding that autistic adults did not donate more to charity when observed. Yet, in the motivation condition, both typical and autistic adults donated significantly more to the observer when watched, although this effect was significantly attenuated in autistic individuals. Results indicate that, while individuals with autism may have the ability to think about reputation, a reduced expectation of reciprocal behavior from others may reduce the degree to which they engage in reputation management. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Cage, Eilidh; Pellicano, Elizabeth] Univ London, Ctr Res Autism & Educ CRAE, Dept Psychol & Human Dev, Inst Educ, London WC1H 0NU, England.
[Cage, Eilidh; Shah, Punit] Univ London Birkbeck Coll, Dept Psychol Sci, London WC1E 7HX, England.
[Pellicano, Elizabeth] Univ Western Australia, Sch Psychol, Perth, WA 6009, Australia.
[Bird, Geoffrey] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London, England.
[Bird, Geoffrey] UCL, Inst Cognit Neurosci, London, England.
RP Cage, E (reprint author), Univ London, Ctr Res Autism & Educ CRAE, Dept Psychol & Human Dev, Inst Educ, 55-59 Gordon Sq, London WC1H 0NU, England.
EM e.cage@ioe.ac.uk
FU Clothworkers' Foundation; Pears Foundation
FX We are extremely grateful to all of the adults who took part in our
study, and to Erica Salomone and Nanami Harada for assistance with task
procedure. Research at the Centre for Research in Autism and Education
(CRAE) is supported by The Clothworkers' Foundation and Pears
Foundation. This experiment was realized using Cogent 2000, developed by
the Cogent 2000 team at the FIL and the ICN, and Cogent Graphics,
developed by John Romaya at the LON at the Wellcome Department of
Imaging Neuroscience.
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NR 44
TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 433
EP 442
DI 10.1002/aur.1313
PG 10
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600013
PM 23836550
ER
PT J
AU Matthews, NL
Goldberg, WA
Lukowski, AF
AF Matthews, Nicole L.
Goldberg, Wendy A.
Lukowski, Angela F.
TI Theory of Mind in Children with Autism Spectrum Disorder: Do Siblings
Matter?
SO AUTISM RESEARCH
LA English
DT Article
DE autism; theory of mind; siblings; false belief
ID FALSE-BELIEF; INDIVIDUAL-DIFFERENCES; EXECUTIVE FUNCTION; METAANALYSIS;
LANGUAGE; RISK
AB Research indicates a positive relation between the sibling constellation and theory of mind (ToM) development in typically developing (TD) children. Less is known about this association in children with autism spectrum disorder (ASD). The current study examined the association among the presence and number of siblings, birth order, and false belief (FB) understanding in children with ASD and a TD comparison group. Two FB tasks (change of contents and change of location) and the Peabody Picture Vocabulary Test were administered to 57 children with ASD and 28 TD children during a home visit. One parent of each child reported on demographics and the sibling constellation. Separate hierarchical regressions controlled for age, receptive language ability, and scores on the Social Communication Questionnaire. In children with ASD, no association was observed between presence or number of siblings and ToM. However, the presence of older (but not younger) siblings was found to be positively associated with ToM. Children with ASD who had at least one older sibling performed similarly to the TD group, whereas children with ASD who had no older siblings performed significantly worse than the TD group. These findings indicate an advantage for FB performance in children with ASD who have an older sibling. They may bear on decisions to include older siblings or peers in intervention programs and may also contribute to a more complete understanding of the origins of individual differences in ToM ability in children with ASD. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc.
C1 [Matthews, Nicole L.; Goldberg, Wendy A.; Lukowski, Angela F.] Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92697 USA.
RP Goldberg, WA (reprint author), Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92697 USA.
EM wendy.goldberg@uci.edu
FU Autism Society of America, San Diego Bernard Rimland Memorial Research
Grant; School of Social Ecology at the University of California, Irvine
Summer Research Grant; University of California, Irvine Undergraduate
Research Opportunities Program
FX We thank the Autism Society of America, San Diego Bernard Rimland
Memorial Research Grant, the School of Social Ecology at the University
of California, Irvine Summer Research Grant, and the University of
California, Irvine Undergraduate Research Opportunities Program for
partial financial support of this project. We gratefully acknowledge the
contributions made by members of the undergraduate research team to data
collection and coding. We also thank the children and parents who
participated in this study.
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NR 42
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-3792
EI 1939-3806
J9 AUTISM RES
JI Autism Res.
PD OCT
PY 2013
VL 6
IS 5
BP 443
EP 453
DI 10.1002/aur.1308
PG 11
WC Behavioral Sciences; Psychology, Developmental
SC Behavioral Sciences; Psychology
GA 238GX
UT WOS:000325933600014
PM 23843293
ER
PT J
AU Longstaffe, KA
Hood, BM
Gilchrist, ID
AF Longstaffe, Kate A.
Hood, Bruce M.
Gilchrist, Iain D.
TI Development of human spatial cognition in a three-dimensional world
SO BEHAVIORAL AND BRAIN SCIENCES
LA English
DT Editorial Material
ID VISUAL-SEARCH; ATTENTION; AUTISM; ONSETS
AB Jeffery et al. accurately identify the importance of developing an understanding of spatial reference frames in a three-dimensional world. We examine human spatial cognition via a unique paradigm that investigates the role of saliency and adjusting reference frames. This includes work with adults, typically developing children, and children who develop non-typically (e.g., those with autism).
C1 [Longstaffe, Kate A.; Hood, Bruce M.; Gilchrist, Iain D.] Univ Bristol, Sch Expt Psychol, Bristol BS8 1TU, Avon, England.
RP Longstaffe, KA (reprint author), Univ Bristol, Sch Expt Psychol, Bristol BS8 1TU, Avon, England.
EM Kate.longstaffe@Bristol.ac.uk; Bruce.Hood@Bristol.ac.uk;
Iain.gilchrist@Bristol.ac.uk
CR Baron-Cohen S, 2008, Q J EXP PSYCHOL, V61, P64, DOI 10.1080/17470210701508749
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NR 12
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0140-525X
EI 1469-1825
J9 BEHAV BRAIN SCI
JI Behav. Brain Sci.
PD OCT
PY 2013
VL 36
IS 5
BP 556
EP 556
DI 10.1017/S0140525X13000459
PG 1
WC Psychology, Biological; Behavioral Sciences; Neurosciences
SC Psychology; Behavioral Sciences; Neurosciences & Neurology
GA 234YR
UT WOS:000325681000043
PM 24103610
ER
PT J
AU Koolen, S
Vissers, CTWM
Egger, JIM
Verhoeven, L
AF Koolen, Sophieke
Vissers, Constance Th. W. M.
Egger, Jos I. M.
Verhoeven, Ludo
TI Can monitoring in language comprehension in Autism Spectrum Disorder be
modulated? Evidence from event-related potentials
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Autism Spectrum Disorder; Language; Cognitive control; Monitoring;
Event-related potentials; P600 effect
ID READING-COMPREHENSION; POOR COMPREHENDERS; PARSING ROUTINES; BRAIN
RESPONSE; PERCEPTION; SENTENCES; DISCOURSE; ABILITY; ERPS; HEURISTICS
AB The present study examined language comprehension in Autism Spectrum Disorder (ASD) in light of monitoring. It was studied whether individuals with ASD monitor their language perception, and whether monitoring during language perception could be modulated with instructions. We presented higher-level (semantic) linguistic violations and lower-level (orthographic) linguistic violations in a free reading condition and in an instructed condition, recording event-related potentials. For control participants, a monitoring response as tapped by the P600 effect was found to semantically and orthographically incorrect input in both conditions. For participants with ASD, however, a monitoring response to semantically implausible input, tapped by the P600, was found only in the instructed condition. For orthographic errors monitoring was observed both in the free reading and in the instructed condition. This suggests that people with ASD are less inclined than typical individuals to monitor their perception of higher-level linguistic input, but that this can be enhanced with instructions. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Koolen, Sophieke; Egger, Jos I. M.; Verhoeven, Ludo] Radboud Univ Nijmegen, Inst Behav Sci, NL-6500 HE Nijmegen, Netherlands.
[Vissers, Constance Th. W. M.; Egger, Jos I. M.] Vincent van Gogh Inst Psychiat, Ctr Excellence Neuropsychiat, NL-5803 AC Venray, Netherlands.
[Vissers, Constance Th. W. M.; Egger, Jos I. M.] Radboud Univ Nijmegen, Ctr Cognit, Donders Inst Brain Cognit & Behav, NL-6500 HE Nijmegen, Netherlands.
RP Koolen, S (reprint author), Radboud Univ Nijmegen, Inst Behav Sci, POB 9104, NL-6500 HE Nijmegen, Netherlands.
EM s.koolen@pwo.ru.nl; cvissers@vvgi.nl; j.egger@psych.ru.nl;
l.verhoeven@pwo.ru.nl
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NR 63
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD OCT
PY 2013
VL 94
IS 2
BP 354
EP 368
DI 10.1016/j.biopsycho.2013.07.008
PG 15
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
Experimental
SC Psychology; Behavioral Sciences
GA 232BI
UT WOS:000325462900014
PM 23927989
ER
PT J
AU Mathersul, D
McDonald, S
Rushby, JA
AF Mathersul, Danielle
McDonald, Skye
Rushby, Jacqueline A.
TI Automatic facial responses to briefly presented emotional stimuli in
autism spectrum disorder
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Autism; Asperger's; EMG; Emotion; Backward mask; Skin conductance
ID HIGH-FUNCTIONING AUTISM; TYPICALLY DEVELOPING-CHILDREN;
ASPERGER-SYNDROME; ORIENTING REFLEX; INDIVIDUAL-DIFFERENCES; MIMICRY
REACTIONS; REVISED VERSION; BASIC EMOTIONS; NORMAL ADULTS; EXPRESSIONS
AB Emotion processing, including automatic facial mimicry, plays an important role in social reciprocity. Disruptions in these processes have implications for individuals with impaired social functioning, such as autism spectrum disorders (ASDs). Past research has demonstrated that ASDs are impaired in the recognition of briefly presented emotions and display atypical mimicry of emotions presented for protracted duration. Mimicry (electromyography; EMG) of briefly presented emotions was investigated in adults with ASDs. Concurrent measures of skin conductance and cardiac responses were used as markers of orientation and stimulus detection, respectively. A backward masking task was employed whereby the emotional face (happy, angry) was presented for 30 ms followed by a neutral face "mask". An implicit comparison task required rapid gender identification. The ASD group failed to differentiate by valence in their EMG (zygomaticus, corrugator) and demonstrated atypical pre- and post-stimulus arousal. These findings may provide a potential mechanism for marked deficits in social reciprocity. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Mathersul, Danielle; McDonald, Skye; Rushby, Jacqueline A.] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
RP Mathersul, D (reprint author), Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
EM d.mathersul@unsw.edu.au
RI McDonald, Skye/G-4118-2014
OI McDonald, Skye/0000-0003-0723-6094
FU Australian Postgraduate Award (APA); Australian National Health and
Medical Research Council (NHMRC) Postdoctoral Fellowship [APP1013796];
Australian National Health and Medical Research Council (NHMRC)
FX DM is supported by an Australian Postgraduate Award (APA). JAR is
supported by an Australian National Health and Medical Research Council
(NHMRC) Postdoctoral Fellowship (Clinical Training; APP1013796). This
research was funded by the Australian National Health and Medical
Research Council (NHMRC). We would like to thank the individuals who
gave their time to participate in this study, and the clinicians who
assisted with participant recruitment.
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NR 118
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD OCT
PY 2013
VL 94
IS 2
BP 397
EP 407
DI 10.1016/j.biopsycho.2013.08.004
PG 11
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
Experimental
SC Psychology; Behavioral Sciences
GA 232BI
UT WOS:000325462900018
PM 23998995
ER
PT J
AU Dababnah, S
Parish, SL
AF Dababnah, Sarah
Parish, Susan L.
TI "At a moment, you could collapse": Raising children with autism in the
West Bank
SO CHILDREN AND YOUTH SERVICES REVIEW
LA English
DT Article
DE Autism; ASDs; Caregiving; Coping; Palestinians; West Bank
ID SPECTRUM DISORDER; PARENTING STRESS; SOCIAL SUPPORT; PRESCHOOL-CHILDREN;
DEPRESSED MOOD; MOTHERS; HEALTH; SERVICES; FATHERS; ISRAEL
AB The current qualitative study examined knowledge, attitudes, burdens and coping strategies related to caring for a child with an autism spectrum disorder (ASD) in the West Bank. Based on a sample of 24 Palestinian parents, the study found that parents struggled with financial stressors, child behavioral and medical challenges, and depression. Few parents were aware of ASDs prior to their children's diagnoses. Furthermore, discrimination and stigma from extended family members and the larger community intensified parents' feelings of shame and experiences of social isolation. While some parents coped by withdrawing from the community or denying the diagnosis, others aimed to increase social interactions and access information. Religious coping was found to be partly adaptive for some of the participants. The study underscored the vital need to increase community awareness of ASDs and increase social support for parents in the West Bank. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Dababnah, Sarah] Univ N Carolina, Sch Social Work, Chapel Hill, NC 27599 USA.
[Parish, Susan L.] Brandeis Univ, Heller Sch Social Policy & Management, Waltham, MA 02454 USA.
RP Dababnah, S (reprint author), Univ N Carolina, Sch Social Work, 325 Pittsboro St,CB 3550, Chapel Hill, NC 27599 USA.
EM dababnah@unc.edu; slp@brandeis.edu
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NR 43
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0190-7409
EI 1873-7765
J9 CHILD YOUTH SERV REV
JI Child. Youth Serv. Rev.
PD OCT
PY 2013
VL 35
IS 10
BP 1670
EP 1678
DI 10.1016/j.childyouth.2013.07.007
PG 9
WC Family Studies; Social Work
SC Family Studies; Social Work
GA 231BR
UT WOS:000325388500002
ER
PT J
AU Damico, JS
Lynch, KE
AF Damico, Jack S.
Lynch, Karen E.
TI Theory and practice in action: The contributions of Michael Perkins to
clinical linguistics
SO CLINICAL LINGUISTICS & PHONETICS
LA English
DT Article
DE Clinical linguistics; Michael R. Perkins; pragmatics
ID WILLIAMS-SYNDROME; LANGUAGE; COMMUNICATION; PRAGMATICS; AUTISM;
STRATEGIES; DISORDERS; ENGLISH
AB This article reviews the scholarly contributions of Michael R. Perkins in the discipline of clinical linguistics and provides some indication of the reasons that he has been so successful. Three primary attributes were described through an analysis of his publications.
C1 [Damico, Jack S.] SE Louisiana Univ, Univ Louisiana Lafayette, Dept Commun Disorders, Lafayette, LA USA.
[Lynch, Karen E.] SE Louisiana Univ, Univ Louisiana Lafayette, Dept Speech & Hearing Sci, Lafayette, LA USA.
RP Damico, JS (reprint author), Univ Louisiana Lafayette, Dept Commun Disorders, POB 43170, Lafayette, LA 70504 USA.
EM jsdamico@louisiana.edu
CR Ball M., 2008, HDB CLIN LINGUISTICS
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NR 41
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0269-9206
EI 1464-5076
J9 CLIN LINGUIST PHONET
JI Clin. Linguist. Phon.
PD OCT-NOV
PY 2013
VL 27
IS 10-11
BP 736
EP 745
DI 10.3109/02699206.2013.816782
PG 10
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 235JF
UT WOS:000325713600002
PM 24067166
ER
PT J
AU Muskett, T
Body, R
AF Muskett, Tom
Body, Richard
TI The case for multimodal analysis of atypical interaction: Questions,
answers and gaze in play involving a child with autism
SO CLINICAL LINGUISTICS & PHONETICS
LA English
DT Article
DE Answers; autism; clinical linguistics; conversation analysis; gaze;
multimodality; questions
ID CONVERSATION ANALYSIS
AB Conversation Analysis (CA) continues to accrue interest within clinical linguistics as a methodology that can enable elucidation of structural and sequential orderliness in interactions involving participants who produce ostensibly disordered communication behaviours. However, it can be challenging to apply CA to re-examine clinical phenomena that have initially been defined in terms of linguistics, as a logical starting point for analysis may be to focus primarily on the organisation of language ("talk'') in such interactions. In this article, we argue that CA's methodological power can only be fully exploited in this research context when a multimodal analytic orientation is adopted, where due consideration is given to participants' co-ordinated use of multiple semiotic resources including, but not limited to, talk (e.g. gaze, embodied action, object use and so forth). To evidence this argument, a two-layered analysis of unusual question-answer sequences in a play episode involving a child with autism is presented. It is thereby demonstrated that only when the scope of enquiry is broadened to include gaze and other embodied action can an account be generated of orderliness within these sequences. This finding has important implications for CA's application as a research methodology within clinical linguistics.
C1 [Muskett, Tom; Body, Richard] Univ Sheffield, Dept Human Commun Sci, Sheffield S10 2TS, S Yorkshire, England.
RP Muskett, T (reprint author), Univ Sheffield, Dept Human Commun Sci, 362 Mushroom Lane, Sheffield S10 2TS, S Yorkshire, England.
EM t.muskett@sheffield.ac.uk
CR Ball M., 2008, HDB CLIN LINGUISTICS
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NR 27
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0269-9206
EI 1464-5076
J9 CLIN LINGUIST PHONET
JI Clin. Linguist. Phon.
PD OCT-NOV
PY 2013
VL 27
IS 10-11
BP 837
EP 850
DI 10.3109/02699206.2013.816780
PG 14
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 235JF
UT WOS:000325713600008
PM 24067142
ER
PT J
AU Shuvarikov, A
Campbell, IM
Dittwald, P
Neill, NJ
Bialer, MG
Moore, C
Wheeler, PG
Wallace, SE
Hannibal, MC
Murray, MF
Giovanni, MA
Terespolsky, D
Sodhi, S
Cassina, M
Viskochil, D
Moghaddam, B
Herman, K
Brown, CW
Beck, CR
Gambin, A
Cheung, SW
Patel, A
Lamb, AN
Shaffer, LG
Ellison, JW
Ravnan, JB
Stankiewicz, P
Rosenfeld, JA
AF Shuvarikov, Andrey
Campbell, Ian M.
Dittwald, Piotr
Neill, Nicholas J.
Bialer, Martin G.
Moore, Christine
Wheeler, Patricia G.
Wallace, Stephanie E.
Hannibal, Mark C.
Murray, Michael F.
Giovanni, Monica A.
Terespolsky, Deborah
Sodhi, Sandi
Cassina, Matteo
Viskochil, David
Moghaddam, Billur
Herman, Kristin
Brown, Chester W.
Beck, Christine R.
Gambin, Anna
Cheung, Sau Wai
Patel, Ankita
Lamb, Allen N.
Shaffer, Lisa G.
Ellison, Jay W.
Ravnan, J. Britt
Stankiewicz, Pawel
Rosenfeld, Jill A.
TI Recurrent HERV-H-Mediated 3q13.2-q13.31 Deletions Cause a Syndrome of
Hypotonia and Motor, Language, and Cognitive Delays
SO HUMAN MUTATION
LA English
DT Article
DE 3q13; microdeletion; hypotonia; NAHR; recurrent; developmental delay;
microarray; HERV-H
ID COPY-NUMBER VARIATION; HUMAN ENDOGENOUS RETROVIRUSES; GROWTH-ASSOCIATED
PROTEIN-43; MICRODELETION SYNDROME; HUMAN-GENOME; INTERSTITIAL DELETION;
DEVELOPMENTAL DELAY; DYSMORPHIC FEATURES; CORPUS-CALLOSUM;
INTRACHROMOSOMAL RECOMBINATION
AB We describe the molecular and clinical characterization of nine individuals with recurrent, 3.4-Mb, de novo deletions of 3q13.2-q13.31 detected by chromosomal microarray analysis. All individuals have hypotonia and language and motor delays; they variably express mild to moderate cognitive delays (8/9), abnormal behavior (7/9), and autism spectrum disorders (3/9). Common facial features include downslanting palpebral fissures with epicanthal folds, a slightly bulbous nose, and relative macrocephaly. Twenty-eight genes map to the deleted region, including four strong candidate genes, DRD3, ZBTB20, GAP43, and BOC, with important roles in neural and/or muscular development. Analysis of the breakpoint regions based on array data revealed directly oriented human endogenous retrovirus (HERV-H) elements of approximate to 5kb in size and of >95% DNA sequence identity flanking the deletion. Subsequent DNA sequencing revealed different deletion breakpoints and suggested nonallelic homologous recombination (NAHR) between HERV-H elements as a mechanism of deletion formation, analogous to HERV-I-flanked and NAHR-mediated AZFa deletions. We propose that similar HERV elements may also mediate other recurrent deletion and duplication events on a genome-wide scale. Observation of rare recurrent chromosomal events such as these deletions helps to further the understanding of mechanisms behind naturally occurring variation in the human genome and its contribution to genetic disease. (C) 2013 Wiley Periodicals, Inc.
C1 [Shuvarikov, Andrey; Neill, Nicholas J.; Shaffer, Lisa G.; Ellison, Jay W.; Ravnan, J. Britt; Rosenfeld, Jill A.] PerkinElmer Inc, Signature Genom Labs, Spokane, WA 99207 USA.
[Campbell, Ian M.; Neill, Nicholas J.; Brown, Chester W.; Beck, Christine R.; Cheung, Sau Wai; Patel, Ankita; Stankiewicz, Pawel] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Dittwald, Piotr; Gambin, Anna] Univ Warsaw, Inst Informat, Warsaw, Poland.
[Dittwald, Piotr] Univ Warsaw, Coll Interfac Individual Studies Math & Nat Sci, Warsaw, Poland.
[Bialer, Martin G.; Moore, Christine] Cohen Childrens Med Ctr New York, Manhasset, NY USA.
[Wheeler, Patricia G.] Nemours Childrens Clin, Orlando, FL USA.
[Wallace, Stephanie E.; Hannibal, Mark C.] Seattle Childrens Hosp, Seattle, WA USA.
[Murray, Michael F.; Giovanni, Monica A.] Brigham & Womens Hosp, Boston, MA 02115 USA.
[Terespolsky, Deborah; Sodhi, Sandi] Credit Valley Hosp, Mississauga, ON, Canada.
[Cassina, Matteo] Univ Padua, Dept Womens & Childrens Hlth, Clin Genet Unit, I-35100 Padua, Italy.
[Viskochil, David] Univ Utah, Dept Pediat, Div Med Genet, Salt Lake City, UT USA.
[Moghaddam, Billur] Kaiser Permanente, Dept Clin Genet, Oakland, CA USA.
[Herman, Kristin] Univ Calif, Div Genet, Davis Med Invest Neurodev Disorders Inst, Sacramento, CA USA.
[Brown, Chester W.] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
[Gambin, Anna] Polish Acad Sci, Mossakowski Med Res Ctr, Warsaw, Poland.
[Lamb, Allen N.] Univ Utah, Dept Pathol, ARUP Labs, Salt Lake City, UT USA.
RP Stankiewicz, P (reprint author), Baylor Coll Med, Dept Mol & Human Genet, 1 Baylor Plaza,Rm ABBR R809, Houston, TX 77030 USA.
EM pawels@bcm.edu; Jill.Mokry@perkinelmer.com
FU Polish National Science Center [2012/06/M/ST6/00438]; European Social
Fund [UDA-POKL.04.01.01-00-072/09-00]
FX Contract grant sponsors: Polish National Science Center
(2012/06/M/ST6/00438); European Social Fund
(UDA-POKL.04.01.01-00-072/09-00).
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NR 77
TC 9
Z9 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1059-7794
EI 1098-1004
J9 HUM MUTAT
JI Hum. Mutat.
PD OCT
PY 2013
VL 34
IS 10
BP 1415
EP 1423
DI 10.1002/humu.22384
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 222SW
UT WOS:000324752700015
PM 23878096
ER
PT J
AU Gronborg, TK
Schendel, DE
Parner, ET
AF Gronborg, Therese K.
Schendel, Diana E.
Parner, Erik T.
TI Recurrence of Autism Spectrum Disorders in Full- and Half-Siblings and
Trends Over Time A Population-Based Cohort Study
SO JAMA PEDIATRICS
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDER; PSYCHIATRIC-DISORDERS; EPIDEMIOLOGIC
SURVEY; FAMILY-HISTORY; RISK-FACTORS; TWIN PAIRS; PREVALENCE; CHILDREN
AB IMPORTANCE To date, this is the first population-based study to examine the recurrence risk for autism spectrum disorders (ASDs), including time trends, and the first study to consider the ASDs recurrence risk for full-and half-siblings.
OBJECTIVES To estimate the relative recurrence risk for ASDs in a Danish population, including recurrence in full-and half-siblings, and to examine time trends in ASDs relative to the recurrence risk.
DESIGN, SETTING, AND PARTICIPANTS Population-based cohort study in Denmark. All children (about 1.5 million) born in Denmark between January 1, 1980, and December 31, 2004, were identified and followed up to December 31, 2010. We identified a maternal sibling subcohort derived from mothers with at least 2 children and a paternal sibling subcohort derived from fathers with at least 2 children.
EXPOSURES Children having an older sibling with ASDs are compared with children not having an older sibling with ASDs.
MAIN OUTCOMES AND MEASURES The adjusted hazard ratio for ASDs among children having an older sibling with ASDs compared with children not having an older sibling with ASDs.
RESULTS The overall relative recurrence risk for ASDs was 6.9 (95% CI, 6.1-7.8), and it did not change significantly over time; similar risks were observed in maternal and paternal full-siblings. The relative recurrence risks were 2.4 (95% CI, 1.4-4.1) for maternal half-siblings and 1.5 (95% CI, 0.7-3.4) for paternal half-siblings.
CONCLUSIONS AND RELEVANCE Our population-based recurrence risk estimate is lower than the recently reported estimates from clinical samples. Our results demonstrate no time trend in the ASDs recurrence risk as seen in the ASDs prevalence. The difference in the recurrence risk between full-and half-siblings supports the role of genetics in ASDs, while the significant recurrence risk in maternal half-siblings may support the role of factors associated with pregnancy and the maternal intrauterine environment in ASDs.
C1 [Gronborg, Therese K.; Parner, Erik T.] Aarhus Univ, Dept Publ Hlth, Biostat Sect, DK-8000 Aarhus C, Denmark.
[Schendel, Diana E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Gronborg, TK (reprint author), Aarhus Univ, Dept Publ Hlth, Biostat Sect, Bartholins Alle 2, DK-8000 Aarhus C, Denmark.
EM therese@biostat.au.dk
FU Aarhus University
FX This study is funded by Aarhus University.
CR Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
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World Health Organization, 1965, INT CLASS DIS 8 REV
World Health Organization, 1992, INT STAT CLASS DIS 1
NR 32
TC 23
Z9 23
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-6203
EI 2168-6211
J9 JAMA PEDIATR
JI JAMA Pediatr.
PD OCT
PY 2013
VL 167
IS 10
BP 947
EP 953
DI 10.1001/jamapediatrics.2013.2259
PG 7
WC Pediatrics
SC Pediatrics
GA 232GQ
UT WOS:000325480900017
PM 23959427
ER
PT J
AU Gregory, SG
Anthopolos, R
Osgood, CE
Grotegut, CA
Miranda, ML
AF Gregory, Simon G.
Anthopolos, Rebecca
Osgood, Claire E.
Grotegut, Chad A.
Miranda, Marie Lynn
TI Association of Autism With Induced or Augmented Childbirth in North
Carolina Birth Record (1990-1998) and Education Research (1997-2007)
Databases
SO JAMA PEDIATRICS
LA English
DT Article
ID NEONATAL RISK-FACTORS; SPECTRUM DISORDERS; COMPREHENSIVE METAANALYSIS;
SEX-DIFFERENCES; OXYTOCIN; DINOPROSTONE; MISOPROSTOL; INDUCTION;
INFANTS; LABOR
AB IMPORTANCE One in 88 children in the United States is diagnosed as having autism spectrum disorder. Significant interest centers on understanding the environmental factors that may contribute to autism risk.
OBJECTIVE To examine whether induced (stimulating uterine contractions prior to the onset of spontaneous labor) and/or augmented (increasing the strength, duration, or frequency of uterine contractions with spontaneous onset of labor) births are associated with increased odds of autism.
DESIGN, SETTING, AND PARTICIPANTS We performed an epidemiological analysis using multivariable logistic regression modeling involving the North Carolina Detailed Birth Record and Education Research databases. The study featured 625 042 live births linked with school records, including more than 5500 children with a documented exceptionality designation for autism.
EXPOSURES Induced or augmented births.
MAIN OUTCOMES AND MEASURES Autism as assessed by exceptionality designations in child educational records.
RESULTS Compared with children born to mothers who received neither labor induction nor augmentation, children born to mothers who were induced and augmented, induced only, or augmented only experienced increased odds of autism after controlling for potential confounders related to socioeconomic status, maternal health, pregnancy-related events and conditions, and birth year. The observed associations between labor induction/augmentation were particularly pronounced in male children.
CONCLUSIONS AND RELEVANCE Our work suggests that induction/augmentation during childbirth is associated with increased odds of autism diagnosis in childhood. While these results are interesting, further investigation is needed to differentiate among potential explanations of the association including underlying pregnancy conditions requiring the eventual need to induce/augment, the events of labor and delivery associated with induction/augmentation, and the specific treatments and dosing used to induce/augment labor (eg, exogenous oxytocin and prostaglandins).
C1 [Gregory, Simon G.] Duke Univ, Med Ctr, Dept Med, Ctr Human Genet, Durham, NC 27710 USA.
[Gregory, Simon G.] Duke Univ, Med Ctr, Duke Inst Mol Physiol, Durham, NC 27710 USA.
[Anthopolos, Rebecca; Miranda, Marie Lynn] Univ Michigan, Childrens Environm Hlth Initiat, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA.
[Osgood, Claire E.] Duke Univ, Childrens Environm Hlth Initiat, Durham, NC 27710 USA.
[Grotegut, Chad A.] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Durham, NC 27710 USA.
[Miranda, Marie Lynn] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
RP Gregory, SG (reprint author), Duke Univ, Med Ctr, Duke Ctr Human Genet, 905 S LaSalle St, Durham, NC 27710 USA.
EM simon.gregory@duke.edu
FU United States Environmental Protection Agency [RD-83329301]
FX Support for this research was provided by funding from the United States
Environmental Protection Agency (RD-83329301) (Mss Anthopolos and Osgood
and Dr Miranda).
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NR 42
TC 28
Z9 28
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-6203
EI 2168-6211
J9 JAMA PEDIATR
JI JAMA Pediatr.
PD OCT
PY 2013
VL 167
IS 10
BP 959
EP 966
DI 10.1001/jamapediatrics.2013.2904
PG 8
WC Pediatrics
SC Pediatrics
GA 232GQ
UT WOS:000325480900019
PM 23938610
ER
PT J
AU Cheremshynski, C
Lucyshyn, JM
Olson, DL
AF Cheremshynski, Christy
Lucyshyn, Joseph M.
Olson, Deborah L.
TI Implementation of a Culturally Appropriate Positive Behavior Support
Plan With a Japanese Mother of a Child With Autism: An Experimental and
Qualitative Analysis
SO JOURNAL OF POSITIVE BEHAVIOR INTERVENTIONS
LA English
DT Article
DE positive behavior support; behavioral parent training; culturally
responsive service delivery; single-subject research
ID FAMILY; INTERVENTION
AB The purpose of this study was to empirically investigate a family-centered approach to positive behavior support (PBS) that was designed to be culturally responsive to families of diverse linguistic and cultural backgrounds. A Japanese mother and a child with autism were the primary participants. Multiple research methods were used. A single-subject withdrawal design evaluated the functional relation between parent implementation of a culturally informed PBS plan and improvements in child behavior and participation in a dinner routine. Qualitative case study methods guided an understanding of the family's culture, the mother's perspectives on the PBS plan and outcomes, and the interventionist's perspectives on the provision of behavior support to the family. Quantitative results documented a functional relation between implementation of the PBS plan and improvements in child behavior and participation in the dinner routine. Qualitative results provided a rich description of the parent's and interventionist's experience and perspective. Three themes emerged: (a) developing a rapport informed by family culture; (b) working with a cultural guide to facilitate understanding the family's cultural values, beliefs, and parenting practices; and (c) accommodating the mother's cross-cultural values and beliefs. Contributions to the literature and implications for behavior interventionists working with families of diverse cultural backgrounds are discussed.
C1 [Cheremshynski, Christy; Lucyshyn, Joseph M.] Univ British Columbia, Vancouver, BC V5N 2E5, Canada.
[Olson, Deborah L.] Univ Oregon, Eugene, OR 97403 USA.
RP Lucyshyn, JM (reprint author), Univ British Columbia, Fac Educ, 2125 Main Mall, Vancouver, BC V5N 2E5, Canada.
EM joe.lucyshyn@ubc.ca
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NR 26
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1098-3007
EI 1538-4772
J9 J POSIT BEHAV INTERV
JI J. Posit. Behav. Interv.
PD OCT
PY 2013
VL 15
IS 4
BP 242
EP 253
DI 10.1177/1098300712459904
PG 12
WC Psychology, Clinical; Education, Special
SC Psychology; Education & Educational Research
GA 220NC
UT WOS:000324590300007
ER
PT J
AU Baweja, R
Calhoun, S
Baweja, R
Singareddy, R
AF Baweja, R.
Calhoun, S.
Baweja, R.
Singareddy, R.
TI Sleep problems in children
SO MINERVA PEDIATRICA
LA English
DT Article
DE Sleep disorders; Child; Adolescent; Sleep apnea, obstructive; Sleep
disorders, circadian rhythm
ID SCHOOL-AGED CHILDREN; EXCESSIVE DAYTIME SLEEPINESS; DEFICIT
HYPERACTIVITY DISORDER; RESTLESS-LEGS-SYNDROME;
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; RANDOMIZED CONTROLLED-TRIAL;
AUTISM SPECTRUM DISORDERS; YOUNG-CHILDREN; RISK-FACTORS; BEHAVIORAL
TREATMENT
AB Sleep complaints and sleep disorders are common during childhood and adolescence. The impact of not getting enough sleep may affect children's' physical health as well emotional, cognitive and social development. Insomnia, sleep-disordered breathing, para-somnias and sleep disturbances associated with medical and psychiatric disorders are some of the commonly encountered sleep disorders in this age group. Changes in sleep architecture and the amount of sleep requirement associated with each stage of development should be considered during an evaluation of sleep disorders in children. Behavioral treatments should be used initially wherever possible especially considering that most pharmacologic agents used to treat pediatric sleep disorders are off-label. In this review we address the most common sleep problems in children/adolescents as they relate to prevalence, presentation and symptoms, evaluation and management.
C1 [Baweja, R.; Calhoun, S.; Baweja, R.; Singareddy, R.] Penn State Hershey Med Ctr, Dept Psychiat, Hershey, PA USA.
RP Baweja, R (reprint author), Milton S Hershey Med Ctr, Dept Psychiat H073, 500 Univ Dr, Hershey, PA 17033 USA.
EM rbaweja@hmc.psu.edu
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NR 97
TC 1
Z9 1
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4946
EI 1827-1715
J9 MINERVA PEDIATR
JI Minerva Pediat.
PD OCT
PY 2013
VL 65
IS 5
BP 457
EP 472
PG 16
WC Pediatrics
SC Pediatrics
GA 235PW
UT WOS:000325734200001
PM 24056373
ER
PT J
AU Uhrskov, L
AF Uhrskov, L.
TI Autism and other neurodevelopmental disorders
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Book Review
C1 [Uhrskov, L.] Aarhus Univ Hosp, Dept M, Risskov, Denmark.
RP Uhrskov, L (reprint author), Aarhus Univ Hosp, Dept M, Risskov, Denmark.
EM lisbeth.uhrskov@ps.rm.dk
CR HANSEN RL, 2012, AUTISM NEURODEVELOPM
NR 1
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD OCT
PY 2013
VL 128
IS 4
BP 325
EP 325
DI 10.1111/acps.12190
PG 1
WC Psychiatry
SC Psychiatry
GA 224WQ
UT WOS:000324922700017
ER
PT J
AU Bertsch, K
Gamer, M
Schmidt, B
Schmidinger, I
Walther, S
Kastel, T
Schnell, K
Buchel, C
Domes, G
Herpertz, SC
AF Bertsch, Katja
Gamer, Matthias
Schmidt, Brigitte
Schmidinger, Ilinca
Walther, Stephan
Kaestel, Thorsten
Schnell, Knut
Buechel, Christian
Domes, Gregor
Herpertz, Sabine C.
TI Oxytocin and Reduction of Social Threat Hypersensitivity in Women With
Borderline Personality Disorder
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; EMOTIONAL FACES; INTRANASAL OXYTOCIN; FEMALE
ADOLESCENTS; FACIAL EXPRESSIONS; HUMAN BRAIN; AMYGDALA; HUMANS; GAZE;
RECOGNITION
AB Objective: Patients with borderline personality disorder are characterized by emotional hyperarousal with increased stress levels, anger proneness, and hostile, impulsive behaviors. They tend to ascribe anger to ambiguous facial expressions and exhibit enhanced and prolonged reactions in response to threatening social cues, associated with enhanced and prolonged amygdala responses. Because the intranasal administration of the neuropeptide oxytocin has been shown to improve facial recognition and to shift attention away from negative social information, the authors investigated whether borderline patients would benefit from oxytocin administration.
Method: In a randomized placebo-controlled double-blind group design, 40 nonmedicated, adult female patients with a current DSM-IV diagnosis of borderline personality disorder (two patients were excluded based on hormonal analyses) and 41 healthy women, matched on age, education, and IQ, took part in an emotion classification task 45 Minutes after intranasal administration of 26 IU of oxytocin or placebo. Dependent variables were latencies and number or initial reflexive eye movements measured by eye tracking, manual response latencies, and blood-oxygen-level-dependent responses of the amygdala to angry and fearful compared with happy facial expressions.
Results: Borderline patients exhibited more and faster initial fixation changes to the eyes of angry faces combined with increased amygdala activation in response to angry faces compared with the control group. These abnormal behavioral and neural patterns were normalized after oxytocin administration.
Conclusions: Borderline patients exhibit a hypersensitivity to social threat in early, reflexive stages of information processing. Oxytocin may decrease social threat hypersensitivity and thus reduce anger and aggressive behavior in borderline personality disorder or other psychiatric disorders with enhanced threat-driven reactive aggression.
C1 [Bertsch, Katja] Heidelberg Univ, Dept Gen Psychiat, Heidelberg, Germany.
Univ Med Ctr Hamburg Eppendorf, Dept Syst Neurosci, Hamburg, Germany.
Heidelberg Univ, Dept Neuroradiol, Heidelberg, Germany.
Univ Freiburg, Dept Psychol, Lab Biol & Personal Psychol, D-79106 Freiburg, Germany.
Univ Freiburg, Freiburg Brain Imaging, Univ Med Ctr, D-79106 Freiburg, Germany.
RP Bertsch, K (reprint author), Heidelberg Univ, Dept Gen Psychiat, Heidelberg, Germany.
EM katja.bertsch@med.uni-heidelberg.de
RI Gamer, Matthias/E-7967-2010; Domes, Gregor/J-3369-2013
OI Domes, Gregor/0000-0001-5908-4374
FU German Federal Ministry for Education and Research [01GW0784]
FX Funded by a grant of the German Federal Ministry for Education and
Research (to Dr. Herpertz) (Network "Social Cognition," 01GW0784)
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Z9 20
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD OCT
PY 2013
VL 170
IS 10
BP 1169
EP 1177
DI 10.1176/appi.ajp.2013.13020263
PG 9
WC Psychiatry
SC Psychiatry
GA 230ZV
UT WOS:000325383700018
PM 23982273
ER
PT J
AU Han, ZZ
Ma, YJ
Gong, GL
He, Y
Caramazza, A
Bi, YC
AF Han, Zaizhu
Ma, Yujun
Gong, Gaolang
He, Yong
Caramazza, Alfonso
Bi, Yanchao
TI White matter structural connectivity underlying semantic processing:
evidence from brain damaged patients
SO BRAIN
LA English
DT Article
DE semantic network; DTI; connectome; brain-damaged patient
ID ANATOMO-FUNCTIONAL CONNECTIVITY; AUTISM SPECTRUM DISORDERS; LANGUAGE
COMPREHENSION; SUBCORTICAL APHASIA; SYSTEM; STIMULATION; IMPAIRMENT;
RETRIEVAL; KNOWLEDGE; INSIGHTS
AB Widely distributed brain regions in temporal, parietal and frontal cortex have been found to be involved in semantic processing, but the anatomical connections supporting the semantic system are not well understood. In a group of 76 right-handed brain-damaged patients, we tested the relationship between the integrity of major white matter tracts and the presence of semantic deficits. The integrity of white matter tracts was measured by percentage of lesion voxels obtained in structural imaging and mean fractional anisotropy values obtained in diffusion tensor imaging. Semantic deficits were assessed by jointly considering the performance on three semantic tasks that vary in the modalities of input (visual and auditory stimuli) and output (oral naming and associative judgement). We found that the lesion volume and fractional anisotropy value of the left inferior fronto-occipital fasciculus, left anterior thalamic radiation, and left uncinate fasciculus significantly correlated with severity of impairment in all three semantic tasks. These associations remained significant even when we controlled for a wide range of potential confounding variables, including overall cognitive state, whole lesion volume, or type of brain damage. The effects of these three white matter tracts could not be explained by potential involvement of relevant grey matter, and were (relatively) specific to object semantic processing, as no correlation with performance on non-object semantic control tasks (oral repetition and number processing tasks) was observed. These results underscore the causal role of left inferior fronto-occipital fasciculus, left anterior thalamic radiation, and left uncinate fasciculus in semantic processing, providing direct evidence for (part of) the anatomical skeleton of the semantic network.
C1 [Han, Zaizhu; Ma, Yujun; Gong, Gaolang; He, Yong; Bi, Yanchao] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
[He, Yong; Bi, Yanchao] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China.
[Caramazza, Alfonso] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA.
[Caramazza, Alfonso] Univ Trento, Ctr Mind Brain Sci CIMeC, I-38122 Trento, Italy.
RP Bi, YC (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
EM ybi@bnu.edu.cn
RI Ma, Yujun/F-8722-2014
FU 973 Program [2013CB837300]; Major Project of National Social Science
Foundation [11ZD186]; NSFC [31171073, 31222024, 31271115, 81030028,
31221003, 31000499]; Beijing Natural Science Foundation
[Z111107067311036]; NCET [12-0055, 12-0065]; National Science Fund for
Distinguished Young Scholars [81225012]; Fondazione Cassa di Risparmio
di Trento e Rovereto
FX This study was funded by 973 Program (2013CB837300), Major Project of
National Social Science Foundation (11&ZD186), NSFC (31171073; 31222024;
31271115; 81030028; 31221003; 31000499), Beijing Natural Science
Foundation (Z111107067311036), NCET (12-0055; 12-0065), and the National
Science Fund for Distinguished Young Scholars (81225012, YH). A.C. was
supported by the Fondazione Cassa di Risparmio di Trento e Rovereto.
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NR 69
TC 8
Z9 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
J9 BRAIN
JI Brain
PD OCT
PY 2013
VL 136
BP 2952
EP 2965
DI 10.1093/brain/awt205
PN 10
PG 14
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 228DU
UT WOS:000325166500013
PM 23975453
ER
PT J
AU Wentz, CT
Oettl, LL
Kelsch, W
AF Wentz, Christian T.
Oettl, Lars-Lennart
Kelsch, Wolfgang
TI Optogenetics in psychiatric animal models
SO CELL AND TISSUE RESEARCH
LA English
DT Review
DE Optogenetics; fMRI; Wireless; Dopamine; Animal models; Psychiatric
disorders schizophrenia, autism, addiction)
ID MIDBRAIN DOPAMINE NEURONS; NUCLEUS-ACCUMBENS; OPTICAL CONTROL;
MILLISECOND-TIMESCALE; TRANSGENIC MICE; NEURAL CIRCUITS; LIGHT DELIVERY;
GABA NEURONS; IN-VIVO; SCHIZOPHRENIA
AB Optogenetics is the optical control of neuronal excitability by genetically delivered light-activated channels and pumps and represents a promising tool to fuel the study of circuit function in psychiatric animal models. This review highlights three developments. First, we examine the application of optogenetics in one of the neuromodulators central to the pathophysiology of many psychiatric disorders, the dopaminergic system. We then discuss recent work in translating functional magnetic resonance imaging in small animals (in which optogenetics can be employed to reveal physiological mechanisms underlying disease-related alterations in brain circuits) to patients. Finally, we describe emerging technological developments for circuit manipulation in freely behaving animals.
C1 [Wentz, Christian T.] MIT, Synthet Neurobiol Grp, MIT Media Lab, Cambridge, MA 02139 USA.
[Oettl, Lars-Lennart; Kelsch, Wolfgang] Heidelberg Univ, Dept Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany.
[Kelsch, Wolfgang] Cent Inst Mental Hlth, D-68159 Mannheim, Germany.
RP Kelsch, W (reprint author), Cent Inst Mental Hlth, J5, D-68159 Mannheim, Germany.
EM wolfgang.kelsch@zi-mannheim.de
FU DFG Emmy-Noether-Program [KE1661/1-1]; DFG [SFB636 TP B08]; DFG Graduate
Program "Translational Neuroscience"; Hertz Foundation Myhrvold Family
Fellowship
FX The authors are supported by the DFG Emmy-Noether-Program KE1661/1-1 and
DFG grant SFB636 TP B08 (to W.K.) and a fellowship of the DFG Graduate
Program "Translational Neuroscience" to (L.-L.O.). C. T. W. is supported
by the Hertz Foundation Myhrvold Family Fellowship.
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NR 66
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0302-766X
J9 CELL TISSUE RES
JI Cell Tissue Res.
PD OCT
PY 2013
VL 354
IS 1
BP 61
EP 68
DI 10.1007/s00441-013-1651-5
PG 8
WC Cell Biology
SC Cell Biology
GA 227HO
UT WOS:000325103500006
PM 23695972
ER
PT J
AU Wohr, M
Schwarting, RKW
AF Woehr, Markus
Schwarting, Rainer K. W.
TI Affective communication in rodents: ultrasonic vocalizations as a tool
for research on emotion and motivation
SO CELL AND TISSUE RESEARCH
LA English
DT Review
DE Anxiety; Fear; Autism; Social behavior; Preparedness
ID ANXIETY-RELATED BEHAVIOR; C-FOS EXPRESSION; INDUCED DEFENSE BEHAVIOR;
RAT RATTUS-NORVEGICUS; LISTER-HOODED RATS; ADULT MALE RATS; 22 KHZ
CALLS; JUVENILE RATS; PERIAQUEDUCTAL GRAY; PERIRHINAL CORTEX
AB Mice and rats emit and perceive calls in the ultrasonic range, i.e., above the human hearing threshold of about 20 kHz: so-called ultrasonic vocalizations (USV). Juvenile and adult rats emit 22-kHz USV in aversive situations, such as predator exposure and fighting or during drug withdrawal, whereas 50-kHz USV occur in appetitive situations, such as rough-and-tumble play and mating or in response to drugs of abuse, e.g., amphetamine. Aversive 22-kHz USV and appetitive 50-kHz USV serve distinct communicative functions. Whereas 22-kHz USV induce freezing behavior in the receiver, 50-kHz USV lead to social approach behavior. These opposite behavioral responses are paralleled by distinct patterns of brain activation. Freezing behavior in response to 22-kHz USV is paralleled by increased neuronal activity in brain areas regulating fear and anxiety, such as the amygdala and periaqueductal gray, whereas social approach behavior elicited by 50-kHz USV is accompanied by reduced activity levels in the amygdala but enhanced activity in the nucleus accumbens, a brain area implicated in reward processing. These opposing behavioral responses, together with distinct patterns of brain activation, particularly the bidirectional tonic activation or deactivation of the amygdala elicited by 22-kHz and 50-kHz USV, respectively, concur with a wealth of behavioral and neuroimaging studies in humans involving emotionally salient stimuli, such as fearful and happy facial expressions. Affective ultrasonic communication therefore offers a translational tool for studying the neurobiology underlying socio-affective communication. This is particularly relevant for rodent models of neurodevelopmental disorders characterized by social and communication deficits, such as autism and schizophrenia.
C1 [Woehr, Markus; Schwarting, Rainer K. W.] Univ Marburg, D-35032 Marburg, Germany.
RP Wohr, M (reprint author), Univ Marburg, Gutenbergstr 18, D-35032 Marburg, Germany.
EM markus.woehr@staff.uni-marburg.de
FU Deutsche Forschungsgemeinschaft [DFG WO 1732/1-1]
FX M.W. is supported by the Deutsche Forschungsgemeinschaft (DFG WO
1732/1-1).
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0302-766X
J9 CELL TISSUE RES
JI Cell Tissue Res.
PD OCT
PY 2013
VL 354
IS 1
BP 81
EP 97
DI 10.1007/s00441-013-1607-9
PG 17
WC Cell Biology
SC Cell Biology
GA 227HO
UT WOS:000325103500008
PM 23576070
ER
PT J
AU Cochran, DM
Dvir, Y
Frazier, JA
AF Cochran, David M.
Dvir, Yael
Frazier, Jean A.
TI "Autism-plus" Spectrum Disorders Intersection with Psychosis and the
Schizophrenia Spectrum
SO CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Autism; Psychosis; Schizophrenia; Multiple complex developmental
disorder; Multidimensionally impaired
ID COMPLEX DEVELOPMENTAL DISORDER; CHILDHOOD-ONSET SCHIZOPHRENIA;
HIGH-FUNCTIONING AUTISM; RECEPTOR GENE OXTR; PSYCHIATRIC-DISORDERS;
ASPERGER-SYNDROME; THOUGHT-DISORDER; PDD-NOS; SCHIZOID PERSONALITY;
CORTICAL DEVELOPMENT
AB Patients are often encountered clinically who have autism spectrum disorders (ASD) and also have symptoms suggestive of a comorbid psychotic disorder. A careful assessment for the presence of comorbid disorders is important. However, the core deficits seen in ASD, in social reciprocity, communication, and restricted behaviors and interests, can be mistaken for psychosis. Also, there is a subset of patients who present with a complex neurodevelopmental disorder with impairments that cross diagnostic categories. This article reviews the connections between ASD and psychosis, and highlights the key points to consider in patients who present with these "autism-plus" disorders.
C1 [Cochran, David M.; Frazier, Jean A.] Univ Massachusetts, Sch Med, Dept Psychiat, Div Child & Adolescent Psychiat, Worcester, MA 01605 USA.
[Dvir, Yael] Univ Massachusetts, Sch Med, Dept Psychiat, Div Child & Adolescent Psychiat, Worcester, MA 01655 USA.
RP Cochran, DM (reprint author), Univ Massachusetts, Sch Med, Dept Psychiat, Div Child & Adolescent Psychiat, Biotech 1,Suite 100,365 Plantat St, Worcester, MA 01605 USA.
EM david.cochran@umassmemorial.org
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TC 3
Z9 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1056-4993
J9 CHILD ADOL PSYCH CL
JI Child Adolesc. Psychiatr. N. Am.
PD OCT
PY 2013
VL 22
IS 4
BP 609
EP +
DI 10.1016/j.chc.2013.04.005
PG 20
WC Psychiatry
SC Psychiatry
GA 228MP
UT WOS:000325191200006
PM 24012076
ER
PT J
AU Asarnow, RF
Forsyth, JK
AF Asarnow, Robert F.
Forsyth, Jennifer K.
TI Genetics of Childhood-onset Schizophrenia
SO CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Childhood-onset schizophrenia; Genetics; Common alleles; GWAS; Copy
number variants; Rare alleles; Autism
ID AUTISM SPECTRUM DISORDERS; DE-NOVO MUTATIONS; OBSTETRIC COMPLICATIONS;
PERSONALITY-DISORDERS; FAMILY; ENDOPHENOTYPES; PSYCHOSIS; GENES;
PREVALENCE; DIAGNOSIS
AB Schizophrenia is a heritable disorder. The genetic architecture of schizophrenia is complex and heterogeneous. This article discusses genetic studies of childhood-onset schizophrenia (COS) and compares findings in familial aggregation, common allele, and rare allele studies of COS with those for adult-onset schizophrenia (AOS). COS seems to be a rare variant of AOS with greater familial aggregation of schizophrenia spectrum disorders and higher occurrence of rare allelic variants. The usefulness of genetic screening for diagnosis and individualized treatment is limited; however, identifying common pathways through which multiple genes adversely affect neural systems offers great promise toward developing novel pharmacologic interventions.
C1 [Asarnow, Robert F.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
[Asarnow, Robert F.; Forsyth, Jennifer K.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA.
RP Asarnow, RF (reprint author), Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
EM rasarnow@mednet.ucla.edu
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NR 47
TC 1
Z9 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1056-4993
J9 CHILD ADOL PSYCH CL
JI Child Adolesc. Psychiatr. N. Am.
PD OCT
PY 2013
VL 22
IS 4
BP 675
EP +
DI 10.1016/j.chc.2013.06.004
PG 14
WC Psychiatry
SC Psychiatry
GA 228MP
UT WOS:000325191200010
PM 24012080
ER
PT J
AU Winder, BM
Wozniak, RH
Parlade, MV
Iverson, JM
AF Winder, Breanna M.
Wozniak, Robert H.
Parlade, Meaghan V.
Iverson, Jana M.
TI Spontaneous Initiation of Communication in Infants at Low and Heightened
Risk for Autism Spectrum Disorders
SO DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
DE autism spectrum disorders; communication; gesture; vocalization
ID JOINT ATTENTION; LANGUAGE-DEVELOPMENT; EARLY IDENTIFICATION; YOUNGER
SIBLINGS; NORMAL-CHILDREN; 2ND YEAR; LIFE; BEHAVIORS; DIAGNOSIS;
PROFILES
AB Communication spontaneously initiated by infants at heightened risk (HR; n = 15) for autism spectrum disorders (ASD) is compared with that in low-risk (LR; n = 15) infants at 13 and 18 months of age. Infants were observed longitudinally during naturalistic in-home interaction and semistructured play with caregivers. At both ages, HR infants spontaneously produced Words, Communicative Non-Word Vocalizations, show and point Gestures, and Gesture + Non-Word Vocalization combinations at lower rates than LR peers. This difference also held for Gesture + Word combinations at 18 but not 13 months. At 36 months, all BR children were evaluated for ASD, and 3 received a diagnosis of autistic disorder. At both 13 and 18 months, these 3 children had been at or near the bottom of the distribution on all spontaneous communication variables.
C1 [Winder, Breanna M.; Wozniak, Robert H.] Bryn Mawr Coll, Dept Psychol, Bryn Mawr, PA 19010 USA.
[Parlade, Meaghan V.; Iverson, Jana M.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
RP Winder, BM (reprint author), Bryn Mawr Coll, Dept Psychol, 101 North Mer Ave, Bryn Mawr, PA 19010 USA.
EM bwinder@brynmawr.edu
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NR 64
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0012-1649
J9 DEV PSYCHOL
JI Dev. Psychol.
PD OCT
PY 2013
VL 49
IS 10
BP 1931
EP 1942
DI 10.1037/a0031061
PG 12
WC Psychology, Developmental
SC Psychology
GA 226OX
UT WOS:000325046800011
PM 23231694
ER
PT J
AU Kancherla, V
Braun, KV
Yeargin-Allsopp, M
AF Kancherla, Vijaya
Braun, Kim Van Naarden
Yeargin-Allsopp, Marshalyn
TI Childhood vision impairment, hearing loss and co-occurring autism
spectrum disorder
SO DISABILITY AND HEALTH JOURNAL
LA English
DT Article
DE Autism spectrum disorder; Children; Developmental disabilities; Hearing
loss; Visually impaired
ID SOCIAL COMMUNICATION DIFFICULTIES; OPTIC-NERVE HYPOPLASIA;
DEVELOPMENTAL-DISABILITIES; YOUNG-CHILDREN; METROPOLITAN ATLANTA;
CONGENITAL-RUBELLA; VISUAL IMPAIRMENT; BLIND-CHILDREN; BIRTH-WEIGHT;
PREVALENCE
AB Background: Limited population-based data on prevalence of childhood vision impairment (VI) and hearing loss (HL), and their co-occurrence with autism spectrum disorder (ASD) exists.
Objective: To examine prevalence and characteristics of VI, HL and co-occurring ASD among 8-year-olds in metropolitan Atlanta 2000-2008.
Methods: We used data from the population-based Metropolitan Atlanta Developmental Disabilities Surveillance Program. Prevalence, birth and parental characteristics, presence and severity of other co-occurring developmental disabilities, and age of earliest identification of ASD, were examined for children with VI and HL, by co-occurring ASD.
Results: VI and HL prevalences were 1.2 and 1.3 per 1000 8-year-olds, respectively. Approximately 6-7% of children with VI or HL had co-occurring ASD. Children with VI or HL with co-occurring ASD differed from those without co-occurring ASD by select birth characteristics and the presence of other co-occurring DDs. The median age of earliest known ASD diagnosis was significantly later among children with VI and ASD compared to children with ASD without VI (79 vs. 56 months). Children with HL and ASD were first evaluated by a community provider significantly earlier than those with ASD without HL (40 vs. 50 months).
Conclusions: The frequency of co-occurring ASD with VI and HL is higher than the population prevalence of ASD. The significant delays in diagnosis of ASD in children with VI and lack of earlier diagnosis of ASD among children with HL despite earlier evaluation highlight the importance of developing screening tools for early identification of ASD among children with VI and HL. Published by Elsevier Inc.
C1 [Kancherla, Vijaya; Braun, Kim Van Naarden; Yeargin-Allsopp, Marshalyn] Ctr Dis Control & Prevent, Dev Disabil Branch, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Kancherla, Vijaya] Assoc Univ Ctr Disabil, Silver Spring, MD 20910 USA.
RP Braun, KV (reprint author), Ctr Dis Control & Prevent, Dev Disabil Branch, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd MS E-86, Atlanta, GA 30333 USA.
EM kbn5@cdc.gov
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NR 49
TC 4
Z9 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1936-6574
J9 DISABIL HEALTH J
JI Disabil. Health J.
PD OCT
PY 2013
VL 6
IS 4
BP 333
EP 342
DI 10.1016/j.dhjo.2013.05.003
PG 10
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health; Rehabilitation
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Rehabilitation
GA 224CJ
UT WOS:000324858900009
PM 24060256
ER
PT J
AU Preskitt, JK
Goldfarb, SS
Mulvihill, BA
Colburn, S
Davis, MM
AF Preskitt, Julie K.
Goldfarb, Samantha S.
Mulvihill, Beverly A.
Colburn, Susan
Davis, Melinda M.
TI Future plans and social/recreational activities of youth with special
health care needs: The implications of parental help in completing
surveys
SO DISABILITY AND HEALTH JOURNAL
LA English
DT Article
DE Youth with special health care needs; Social activity; Recreation;
Future plans; Parental assistance; Parent perception
ID QUALITY-OF-LIFE; AUTISM SPECTRUM DISORDERS; GENERIC CORE SCALES;
YOUNG-ADULTS; INTELLECTUAL DISABILITIES; CEREBRAL-PALSY; PROXY-REPORTS;
CHILDREN; AGREEMENT; ADOLESCENTS
AB Background: A major focus of the literature on youth with special health care needs (YSHCN) is the transition to adult health care. As perceptions of disability are a product of interactions between youth and their environment, it is important to understand youth's needs and experiences beyond health care. Few studies have addressed social/recreational activity participation and future plans and none have included parent/caregiver help in survey completion as a potential factor impacting responses.
Objectives: We describe activity participation and identification of future plans among YSHCN and examine the impact of receiving parent/caregiver assistance to complete a survey on these responses. Implications for research, policy, and practice affecting programs serving and providing transition assistance for YSHCN are discussed.
Methods: Data are from a survey of YSHCN conducted during Alabama's 2010 Title V Maternal and Child Health Needs Assessment. Analyses included descriptive statistics, bivariate analysis, and multivariable logistic regression.
Results: Youth who received help completing the survey were less likely to report participating in certain social/recreational activities and key future plans, including hobbies, getting married, having children, and working for pay.
Conclusions: For YSHCN, parent/caregiver assistance to complete a survey is a critical consideration in analyses and interpretation of results. Whether, how much, and what type of help received may represent a more objective proxy measure of perceptions of condition severity or impact on abilities than do self-reported ratings of these factors. Our results also raise questions about the distinctions between youth and parent/caregiver perceptions of independence, participation, and potential. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Preskitt, Julie K.; Goldfarb, Samantha S.; Mulvihill, Beverly A.] Univ Alabama Birmingham, Dept Hlth Care Org & Policy, Sch Publ Hlth, Birmingham, AL 35294 USA.
RP Preskitt, JK (reprint author), Univ Alabama Birmingham, Dept Hlth Care Org & Policy, Sch Publ Hlth, RPHB 330,1720 2nd Ave S, Birmingham, AL 35294 USA.
EM preskitt@uab.edu
CR American Academy of Pediatrics; American Academy of Family Physicians; American College of Physicians Transitions Clinical Report Authoring Group, 2011, PEDIATRICS, V128, P182
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NR 37
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1936-6574
J9 DISABIL HEALTH J
JI Disabil. Health J.
PD OCT
PY 2013
VL 6
IS 4
BP 343
EP 351
DI 10.1016/j.dhjo.2013.04.010
PG 9
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health; Rehabilitation
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Rehabilitation
GA 224CJ
UT WOS:000324858900010
PM 24060257
ER
PT J
AU Ionita-Laza, I
Lee, S
Makarov, V
Buxbaum, JD
Lin, XH
AF Ionita-Laza, Iuliana
Lee, Seunggeun
Makarov, Vladimir
Buxbaum, Joseph D.
Lin, Xihong
TI Family-based association tests for sequence data, and comparisons with
population-based association tests
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE family- and population-based association tests; sequence data; burden
and variance-component tests
ID GENOME-WIDE ASSOCIATION; RARE VARIANTS; DISEASE VARIANTS; UNIFIED
APPROACH; COMMON VARIANTS; FRAMEWORK; DISORDERS; MUTATIONS; PATTERNS;
DESIGNS
AB Recent advances in high-throughput sequencing technologies make it increasingly more efficient to sequence large cohorts for many complex traits. We discuss here a class of sequence-based association tests for family-based designs that corresponds naturally to previously proposed population-based tests, including the classical Burden and variance-component tests. This framework allows for a direct comparison between the powers of sequence-based association tests with family- vs population-based designs. We show that for dichotomous traits using family-based controls results in similar power levels as the population-based design (although at an increased sequencing cost for the family-based design), while for continuous traits (in random samples, no ascertainment) the population-based design can be substantially more powerful. A possible disadvantage of population-based designs is that they can lead to increased false-positive rates in the presence of population stratification, while the family-based designs are robust to population stratification. We show also an application to a small exome-sequencing family-based study on autism spectrum disorders. The tests are implemented in publicly available software.
C1 [Ionita-Laza, Iuliana; Makarov, Vladimir] Columbia Univ, Dept Biostat, New York, NY 10032 USA.
[Lee, Seunggeun; Lin, Xihong] Harvard Univ, Dept Biostat, Boston, MA 02115 USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Genet, New York, NY USA.
[Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Genom Sci, New York, NY USA.
RP Ionita-Laza, I (reprint author), Columbia Univ, Dept Biostat, 722 West,168th St,6th Floor, New York, NY 10032 USA.
EM ii2135@columbia.edu; xlin@hsph.harvard.edu
FU National Science Foundation [DMS-1100279]; National Institutes of Health
[R01MH095797, 1R03HG005908, MH089025, R37 CA076404, P01CA134294]; Seaver
Foundation
FX The research was partially supported by National Science Foundation
grant DMS-1100279 and National Institutes of Health grants R01MH095797
and 1R03HG005908 (to II-L), a Seaver Foundation grant and National
Institutes of Health grants MH089025 (to JDB) and National Institutes of
Health grants R37 CA076404 and P01CA134294 (to SL and XL).
CR Amos CI, 2007, HUM MOL GENET, V16, pR220, DOI 10.1093/hmg/ddm161
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NR 40
TC 22
Z9 23
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD OCT
PY 2013
VL 21
IS 10
BP 1158
EP 1162
DI 10.1038/ejhg.2012.308
PG 5
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 222JO
UT WOS:000324727200027
PM 23386037
ER
PT J
AU Fruhmesser, A
Blake, J
Haberlandt, E
Baying, B
Raeder, B
Runz, H
Spreiz, A
Fauth, C
Benes, V
Utermann, G
Zschocke, J
Kotzot, D
AF Fruehmesser, Anne
Blake, Jonathon
Haberlandt, Edda
Baying, Bianka
Raeder, Benjamin
Runz, Heiko
Spreiz, Ana
Fauth, Christine
Benes, Vladimir
Utermann, Gerd
Zschocke, Johannes
Kotzot, Dieter
TI Disruption of EXOC6B in a patient with developmental delay, epilepsy,
and a de novo balanced t(2;8) translocation
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
DE balanced translocation; gene disruption; next-generation sequencing
ID EXOCYST; SEC15; PHENOTYPE; INTERACTS; RAB11
AB Most balanced chromosomal aberrations are not associated with a clinical phenotype, however, in some patients they may disrupt gene structure. With the development of various next-generation sequencing techniques, fast and specific analyses of the breakpoint regions of chromosomal rearrangements are possible. Here, we report on a 19-year-old woman with a de novo balanced translocation t(2;8)(p13.2;q22.1) and a severe clinical phenotype including intellectual disability, epilepsy, behavioral features resembling autism, and minor dysmorphic features. By next-generation sequencing, we defined the breakpoints and found disruption of the exocyst complex component 6B (EXOC6B) gene in intron 1 on chromosome 2p13.2 involving two Alu elements with a homology of 81%. No gene was found at the respective breakpoint on chromosome 8. Expression analysis of the EXOC6B in blood lymphocytes and buccal smear revealed reduced expression in the patient in comparison with the control. Our findings in combination with one recently published case and one other patient listed in DECIPHER v5.1 indicate EXOC6B as a gene relevant for intellectual development and electrophysiological stability.
C1 [Fruehmesser, Anne; Spreiz, Ana; Fauth, Christine; Utermann, Gerd; Zschocke, Johannes; Kotzot, Dieter] Med Univ Innsbruck, Dept Med Genet Mol & Clin Pharmacol, Div Human Genet, A-6020 Innsbruck, Austria.
[Blake, Jonathon; Baying, Bianka; Benes, Vladimir] Genom Core Facil, EMBL, Heidelberg, Germany.
[Haberlandt, Edda] Med Univ Innsbruck, Clin Dept Pediat 1, A-6020 Innsbruck, Austria.
[Raeder, Benjamin] Korbel Lab, EMBL, Heidelberg, Germany.
[Runz, Heiko] Heidelberg Univ, Inst Human Genet, Heidelberg, Germany.
RP Kotzot, D (reprint author), Dept Med Genet Mol & Clin Pharmacol, Div Human Genet, Schoepfstr 41, A-6020 Innsbruck, Austria.
EM DieterKotzot@gmx.de
FU TWF-grant [D-151740-020-011]
FX We thank the family for the excellent cooperation. This work was founded
by a TWF-grant (D-151740-020-011) to AS.
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NR 15
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD OCT
PY 2013
VL 21
IS 10
BP 1177
EP 1180
DI 10.1038/ejhg.2013.18
PG 4
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 222JO
UT WOS:000324727200031
PM 23422942
ER
PT J
AU de Boer, M
Toni, I
Willems, RM
AF de Boer, Miriam
Toni, Ivan
Willems, Roel M.
TI What drives successful verbal communication?
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE communication; language; individual differences; mentalizing; Raven's
progressive matrices
ID SEX-DIFFERENCES; PROGRESSIVE MATRICES; EMPATHY QUOTIENT; COGNITION;
NEED; MOTIVATION; MECHANISMS; LANGUAGE; ACCOUNT; AUTISM
AB There is a vast amount of potential mappings between behaviors and intentions in communication: a behavior can indicate a multitude of different intentions, and the same intention can be communicated with a variety of behaviors. Humans routinely solve these many-to-many referential problems when producing utterances for an Addressee. This ability might rely on social cognitive skills, for instance, the ability to manipulate unobservable summary variables to disambiguate ambiguous behavior of other agents ("mentalizing") and the drive to invest resources into changing and understanding the mental state of other agents ("communicative motivation"). Alternatively, the ambiguities of verbal communicative interactions might be solved by general-purpose cognitive abilities that process cues that are incidentally associated with the communicative interaction. In this study, we assess these possibilities by testing which cognitive traits account for communicative success during a verbal referential task. Cognitive traits were assessed with psychometric scores quantifying motivation, mentalizing abilities, and general-purpose cognitive abilities, taxing abstract visuo-spatial abilities. Communicative abilities of participants were assessed by using an on-line interactive task that required a speaker to verbally convey a concept to an Addressee. The communicative success of the utterances was quantified by measuring how frequently a number of Evaluators would infer the correct concept. Speakers with high motivational and general-purpose cognitive abilities generated utterances that were more easily interpreted. These findings extend to the domain of verbal communication the notion that motivational and cognitive factors influence the human ability to rapidly converge on shared communicative innovations.
C1 [de Boer, Miriam; Toni, Ivan; Willems, Roel M.] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands.
[Willems, Roel M.] Max Planck Inst Psycholinguist, Nijmegen, Netherlands.
RP de Boer, M (reprint author), Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM miriam.deboer@donders.ru.nl
FU European Union Joint-Action Science and Technology Project
[IST-FP6-003747]; Netherlands Organisation for Scientific Research
(VICI) [453-08-002]
FX The authors thank Iris van Rooij and Mark Blokpoel for their valuable
contribution to the interpretation of the data. This paper is supported
by a grant from the European Union Joint-Action Science and Technology
Project (IST-FP6-003747) and by a grant from the Netherlands
Organisation for Scientific Research (VICI grant #453-08-002).
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NR 38
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD OCT 1
PY 2013
VL 7
AR 622
DI 10.3389/fnhum.2013.00622
PG 8
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 226XF
UT WOS:000325069100001
PM 24101898
ER
PT J
AU Pacey, LKK
Xuan, ICY
Guan, SH
Sussman, D
Henkelman, RM
Chen, Y
Thomsen, C
Hampson, DR
AF Pacey, Laura K. K.
Xuan, Ingrid C. Y.
Guan, Sihui
Sussman, Dafna
Henkelman, R. Mark
Chen, Yan
Thomsen, Christian
Hampson, David R.
TI Delayed myelination in a mouse model of fragile X syndrome
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE; MENTAL-RETARDATION
PROTEIN; MATERNAL IMMUNE ACTIVATION; AUTISTIC-LIKE BEHAVIOR;
CENTRAL-NERVOUS-SYSTEM; BASIC-PROTEIN; OLIGODENDROCYTE DIFFERENTIATION;
CELL-PROLIFERATION; NG2 PROTEOGLYCAN; PURKINJE-CELLS
AB Fragile X Syndrome is the most common inherited cause of autism. Fragile X mental retardation protein (FMRP), which is absent in fragile X, is an mRNA binding protein that regulates the translation of hundreds of different mRNA transcripts. In the adult brain, FMRP is expressed primarily in the neurons; however, it is also expressed in developing glial cells, where its function is not well understood. Here, we show that fragile X (Fmr1) knockout mice display abnormalities in the myelination of cerebellar axons as early as the first postnatal week, corresponding roughly to the equivalent time in human brain development when symptoms of the syndrome first become apparent (1-3 years of age). At postnatal day (PND) 7, diffusion tensor magnetic resonance imaging showed reduced volume of the Fmr1 cerebellum compared with wild-type mice, concomitant with an 80-85% reduction in the expression of myelin basic protein, fewer myelinated axons and reduced thickness of myelin sheaths, as measured by electron microscopy. Both the expression of the proteoglycan NG2 and the number of PDGFR alpha+/NG2+ oligodendrocyte precursor cells were reduced in the Fmr1 cerebellum at PND 7. Although myelin proteins were still depressed at PND 15, they regained wild-type levels by PND30. These findings suggest that impaired maturation or function of oligodendrocyte precursor cells induces delayed myelination in the Fmr1 mouse brain. Our results bolster an emerging recognition that white matter abnormalities in early postnatal brain development represent an underlying neurological deficit in Fragile X syndrome.
C1 [Pacey, Laura K. K.; Xuan, Ingrid C. Y.; Guan, Sihui; Hampson, David R.] Univ Toronto, Dept Pharmaceut Sci, Leslie Dan Fac Pharm, Toronto, ON M5S 3M2, Canada.
[Chen, Yan] Univ Toronto, Fac Med, Toronto, ON M5S 3M2, Canada.
[Hampson, David R.] Univ Toronto, Dept Pharmacol, Fac Med, Toronto, ON M5S 3M2, Canada.
[Sussman, Dafna; Henkelman, R. Mark] Mouse Imaging Ctr MICE, Toronto, ON, Canada.
[Sussman, Dafna; Henkelman, R. Mark] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
[Thomsen, Christian] Lundbeck Res USA, Dept Neuroinflammat, Paramus, NJ USA.
RP Hampson, DR (reprint author), Univ Toronto, Dept Pharmaceut Sci, 144 Coll St, Toronto, ON M5S 3M2, Canada.
EM d.hampson@utoronto.ca
RI Henkelman, Mark/F-3662-2011
FU Canadian Institutes for Health Research; Lundbeck Research USA
FX This work was supported by the Canadian Institutes for Health Research
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NR 62
TC 9
Z9 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD OCT 1
PY 2013
VL 22
IS 19
BP 3920
EP 3930
DI 10.1093/hmg/ddt246
PG 11
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 228CX
UT WOS:000325163900009
PM 23740941
ER
PT J
AU Duffield, TC
Trontel, HG
Bigler, ED
Froehlich, A
Prigge, MB
Travers, B
Green, RR
Cariello, AN
Cooperrider, J
Nielsen, J
Alexander, A
Anderson, J
Fletcher, PT
Lange, N
Zielinski, B
Lainhart, J
AF Duffield, Tyler C.
Trontel, Haley G.
Bigler, Erin D.
Froehlich, Alyson
Prigge, Molly B.
Travers, Brittany
Green, Ryan R.
Cariello, Annahir N.
Cooperrider, Jason
Nielsen, Jared
Alexander, Andrew
Anderson, Jeffrey
Fletcher, P. Thomas
Lange, Nicholas
Zielinski, Brandon
Lainhart, Janet
TI Neuropsychological investigation of motor impairments in autism
SO JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
LA English
DT Article
DE Autism; Network disruption; Motor impairment; Brain volume differences;
Motor cortex volume
ID PERVASIVE DEVELOPMENTAL DISORDERS; FUNCTIONAL MAGNETIC-RESONANCE;
VOXEL-BASED MORPHOMETRY; SPECTRUM DISORDER; BRAIN STRUCTURE;
PARKINSONS-DISEASE; ASPERGERS-SYNDROME; BASAL GANGLIA; GRIP FORCE;
CHILDREN
AB It is unclear how standardized neuropsychological measures of motor function relate to brain volumes of motor regions in autism spectrum disorder (ASD). An all-male sample composed of 59 ASD and 30 controls (ages 5-33 years) completed three measures of motor function: strength of grip (SOG), finger tapping test (FTT), and grooved pegboard test (GPT). Likewise, all participants underwent magnetic resonance imaging with region of interest (ROI) volumes obtained to include the following regions: motor cortex (precentral gyrus), somatosensory cortex (postcentral gyrus), thalamus, basal ganglia, cerebellum, and caudal middle frontal gyrus. These traditional neuropsychological measures of motor function are assumed to differ in motor complexity, with GPT requiring the most followed by FTT and SOG. Performance by ASD participants on the GPT and FTT differed significantly from that of controls, with the largest effect size differences observed on the more complex GPT task. Differences on the SOG task between the two groups were nonsignificant. Since more complex motor tasks tap more complex networks, poorer GPT performance by those with ASD may reflect less efficient motor networks. There was no gross pathology observed in classic motor areas of the brain in ASD, as ROI volumes did not differ, but FTT was negatively related to motor cortex volume in ASD. The results suggest a hierarchical motor disruption in ASD, with difficulties evident only in more complex tasks as well as a potential anomalous size-function relation in motor cortex in ASD.
C1 [Duffield, Tyler C.; Bigler, Erin D.; Green, Ryan R.] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA.
[Trontel, Haley G.] Univ Montana, Dept Psychol, Missoula, MT 59812 USA.
[Bigler, Erin D.] Brigham Young Univ, Ctr Neurosci, Provo, UT 84602 USA.
[Bigler, Erin D.] Univ Utah, Dept Psychiat, Salt Lake City, UT USA.
[Bigler, Erin D.; Fletcher, P. Thomas] Univ Utah, Brain Inst Utah, Salt Lake City, UT USA.
[Froehlich, Alyson; Prigge, Molly B.; Cariello, Annahir N.; Cooperrider, Jason; Nielsen, Jared] Univ Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA.
[Prigge, Molly B.; Cooperrider, Jason; Nielsen, Jared] Univ Utah, Interdept Neurosci Program, Salt Lake City, UT USA.
[Travers, Brittany; Alexander, Andrew; Zielinski, Brandon] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA.
[Alexander, Andrew; Lainhart, Janet] Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI USA.
[Alexander, Andrew; Lainhart, Janet] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA.
[Anderson, Jeffrey] Univ Utah, Dept Radiol, Salt Lake City, UT 84132 USA.
[Fletcher, P. Thomas] Univ Utah, Sch Comp, Salt Lake City, UT USA.
[Lange, Nicholas] Harvard Univ, Dept Psychiat, Boston, MA 02115 USA.
[Lange, Nicholas] Harvard Univ, Dept Biostat, Boston, MA 02115 USA.
[Lange, Nicholas] McLean Hosp, Neurostat Lab, Belmont, MA 02178 USA.
[Zielinski, Brandon] Univ Utah, Sch Med, Dept Pediat & Neurol, Salt Lake City, UT USA.
RP Bigler, ED (reprint author), Brigham Young Univ, Dept Psychol, 1001 SWKT, Provo, UT 84602 USA.
EM erin_bigler@byu.edu
FU National Institute of Mental Health [RO1 MH080826, RO1 MH084795, KO8
MH092697]; Eunice Kennedy Shriver National Institute of Child Health and
Human Development (NICHD) [T32 HD07489, P30 HD003352-45]; Hartwell
Foundation; Primary Children's Foundation Early Career Development
Award; Poelman Foundation
FX The project described was supported by Grants RO1 MH080826 (J.E.L.,
E.D.B., A.L.A., N.L.), RO1 MH084795 (J.E.L., P.T.F., N.L.), and KO8
MH092697 (J.S.A.) from the National Institute of Mental Health; Grants
T32 HD07489 (B.T.) and P30 HD003352-45 (Waisman Center Core Grant) from
the Eunice Kennedy Shriver National Institute of Child Health and Human
Development (NICHD), The Hartwell Foundation (B.T.), and the Primary
Children's Foundation Early Career Development Award (B.Z.). Support
from the Poelman Foundation to Brigham Young University for autism
research is gratefully acknowledged. The authors report no conflicts of
interest. The content is solely the responsibility of the authors and
does not necessarily represent the official views of the National
Institute of Mental Health, the National Institute of Child Health and
Development, or the National Institutes of Health. We thank former
members of the Utah Autism Creative Programs of Excellence in Autism
(CPEA) for their assistance during the early stages of this project. We
sincerely thank the children, adolescents, and adults with autism and
the individuals with typical development who participated in this study
and their families. The assistance of Tracy J. Abildskov with image
analysis and Jo Ann Petrie with manuscript preparation is gratefully
acknowledged.
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NR 104
TC 2
Z9 2
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1380-3395
J9 J CLIN EXP NEUROPSYC
JI J. Clin. Exp. Neuropsychol.
PD OCT 1
PY 2013
VL 35
IS 8
BP 867
EP 881
DI 10.1080/13803395.2013.827156
PG 15
WC Psychology, Clinical; Clinical Neurology; Psychology
SC Psychology; Neurosciences & Neurology
GA 226TQ
UT WOS:000325059300008
PM 23985036
ER
PT J
AU Torres, EB
Isenhower, RW
Yanovich, P
Rehrig, G
Stigler, K
Nurnberger, J
Jose, JV
AF Torres, Elizabeth B.
Isenhower, Robert W.
Yanovich, Polina
Rehrig, Gwendolyn
Stigler, Kimberly
Nurnberger, John
Jose, Jorge V.
TI Strategies to develop putative biomarkers to characterize the female
phenotype with autism spectrum disorders
SO JOURNAL OF NEUROPHYSIOLOGY
LA English
DT Article
DE sex differences; autism; kinesthetic input; decision-making; movement
decision time; stochastic signatures
ID POSTERIOR PARIETAL CORTEX; HIGH-FUNCTIONING AUTISM; 22Q13 DELETION
SYNDROME; CHOICE-REACTION TIME; BASAL GANGLIA; GENDER-DIFFERENCES;
INTERNAL-MODELS; SEX-DIFFERENCES; GASTROINTESTINAL PROBLEMS;
PARKINSONS-DISEASE
AB Current observational inventories used to diagnose autism spectrum disorders (ASD) apply similar criteria to females and males alike, despite developmental differences between the sexes. Recent work investigating the chronology of diagnosis in ASD has raised the concern that females run the risk of receiving a delayed diagnosis, potentially missing a window of opportunity for early intervention. Here, we retake this issue in the context of the objective measurements of natural behaviors that involve decision-making processes. Within this context, we quantified movement variability in typically developing (TD) individuals and those diagnosed with ASD across different ages. We extracted the latencies of the decision movements and velocity-dependent parameters as the hand movements unfolded for two movement segments within the reach: movements intended toward the target and withdrawing movements that spontaneously, without instruction, occurred incidentally. The stochastic signatures of the movement decision latencies and the percent of time to maximum speed differed between males and females with ASD. This feature was also observed in the empirically estimated probability distributions of the maximum speed values, independent of limb size. Females with ASD showed different dispersion than males with ASD. The distinctions found for females with ASD were better appreciated compared with those of TD females. In light of these results, behavioral assessment of autistic traits in females should be performed relative to TD females to increase the chance of detection.
C1 [Torres, Elizabeth B.; Isenhower, Robert W.; Rehrig, Gwendolyn] Rutgers State Univ, Dept Psychol, New Brunswick, NJ 08903 USA.
[Torres, Elizabeth B.] Rutgers State Univ, Rutgers Ctr Cognit Sci, New Brunswick, NJ 08903 USA.
[Torres, Elizabeth B.] Rutgers State Univ, Rutgers Ctr Computat Biomed Imaging & Modeling Co, New Brunswick, NJ 08903 USA.
[Torres, Elizabeth B.] Rutgers State Univ, Rutgers Ctr Movement Disorders, New Brunswick, NJ 08903 USA.
[Torres, Elizabeth B.] Indiana Univ Sch Med, Indianapolis, IN 46202 USA.
[Yanovich, Polina] Rutgers State Univ, Dept Comp Sci, New Brunswick, NJ 08903 USA.
[Stigler, Kimberly; Nurnberger, John] Indiana Univ Sch Med, Riley Hosp Children, Christian Sarkine Autism Treatment Ctr, Dept Psychiat, Indianapolis, IN 46202 USA.
[Jose, Jorge V.] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Dept Phys, Indianapolis, IN 46202 USA.
RP Torres, EB (reprint author), Rutgers State Univ, Dept Psychol, 152 Frelinghuysen Rd, Piscataway, NJ 08854 USA.
EM ebtorres@rci.rutgers.edu
FU National Science Foundation [094158]; New Jersey Governor's Council for
Medical Research and Treatment of Autism [10-403-SCH-E-0]
FX Support for this work was funded by National Science Foundation
Cyber-Enabled Discovery and Innovation-CDI Type I (Idea) grant #094158
to E. B. Torres ("A novel quantitative framework to study lack of social
interactions in autism") and by New Jersey Governor's Council for
Medical Research and Treatment of Autism grant #10-403-SCH-E-0
("Perceptual motor anticipation in individuals with autism spectrum
disorder").
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NR 141
TC 2
Z9 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3077
J9 J NEUROPHYSIOL
JI J. Neurophysiol.
PD OCT
PY 2013
VL 110
IS 7
BP 1646
EP 1662
DI 10.1152/jn.00059.2013
PG 17
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA 230NA
UT WOS:000325346300018
PM 23864377
ER
PT J
AU Singer, B
AF Singer, Barbara
TI Perceptions of School Nurses in the Care of Students With Disabilities
SO JOURNAL OF SCHOOL NURSING
LA English
DT Article
DE special education; disabilities; school nurse education; school nurse;
knowledge; perceptions; self-efficacy; qualitative research
ID AUTISM SPECTRUM DISORDERS; DEVELOPMENTAL-DISABILITIES; PAIN ASSESSMENT;
HEALTH-CARE; INTELLECTUAL DISABILITIES; NURSING-STUDENTS; CHILDREN;
PEOPLE; COMMUNICATION; ATTITUDES
AB Many children are surviving prematurity and serious childhood illnesses due to advances in technology and medical care. As a result, more children are entering public school systems with complex health care needs and intellectual and developmental disabilities. School nurses are responsible for caring for these children; however, many nurses feel unprepared due to a lack education on disability studies in nursing school, difficulty with effective communication, and a lack of experience. A qualitative study was conducted to explore the perceptions and challenges of school nurses who worked with students with intellectual and developmental disabilities. Participants included eight nurses who worked in a public school setting, and data were collected through personal interviews, observations, and field notes. Results were analyzed categorically, and data showed that school nurses identified that they lacked education in disability studies and encountered challenges with communication, conducting health assessments, and screenings in students with intellectual and developmental disabilities.
C1 Natick Publ Sch, Sch Nurse, Natick, MA 01760 USA.
RP Singer, B (reprint author), Natick Publ Sch, Sch Nurse, Natick, MA 01760 USA.
EM bssinger1@gmail.com
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NR 27
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1059-8405
J9 J SCH NURS
JI J. Sch. Nurs.
PD OCT
PY 2013
VL 29
IS 5
BP 329
EP 336
DI 10.1177/1059840512462402
PG 8
WC Nursing
SC Nursing
GA 222PI
UT WOS:000324742900002
PM 23015606
ER
PT J
AU Midouhas, E
Yogaratnam, A
Flouri, E
Charman, T
AF Midouhas, Emily
Yogaratnam, Amy
Flouri, Eirini
Charman, Tony
TI Psychopathology Trajectories of Children With Autism Spectrum Disorder:
The Role of Family Poverty and Parenting
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism spectrum disorder (ASP); household chaos; parenting;
psychopathology; trajectories
ID MATERNAL MENTAL-HEALTH; BEHAVIOR PROBLEMS; PSYCHIATRIC-DISORDERS;
INTELLECTUAL DISABILITY; EMOTIONAL-PROBLEMS; RISK-FACTORS; CHILDHOOD;
SCHOOL; ASSOCIATIONS; ADOLESCENTS
AB Children with autism spectrum disorder (ASD) are reported to have high rates of co-occurring psychopathology. Little is known about risk factors that might contribute to this psychopathology. This study modeled the effect of family poverty on psychopathology trajectories in young children with ASD, and examined whether home organization and maternal warmth and involvement could buffer the effect of poverty on children's psychopathology. Method: The sample comprised 209 children with ASD who participated in the UK's Millennium Cohort Study, a population birth cohort study. Individual trajectories of psychopathology at ages 3, 5, and 7 years were analyzed using growth curve models. Psychopathology was assessed with the Strengths and Difficulties Questionnaire. Results: Children with ASD exhibited increasingly high rates of psychopathology over time. Family poverty was associated with broad and specific (emotional and conduct problems) psychopathology, but not with changes in psychopathology over time. Warmth, involvement, and home organization did not buffer the association of family poverty with psychopathology. However, low warmth explained the relationship between poverty and broad psychopathology, and predicted annual changes in broad psychopathology. Warmth was associated with fewer conduct problems and less hyperactivity, and with an annual decrease in peer and conduct problems. Household chaos was a risk factor for conduct problems, as was maternal involvement for peer problems. Conclusions: Family poverty, low maternal warmth, and household chaos are risk factors for externalizing problems in children with ASP. Maternal warmth may be a key target for intervention, particularly in poorer families of children with ASD.
C1 [Midouhas, Emily; Yogaratnam, Amy; Flouri, Eirini] Univ London, Inst Educ, London WC1H OAA, England.
[Charman, Tony] Kings Coll London, Inst Psychiat, London, England.
RP Midouhas, E (reprint author), Univ London, Inst Educ, Dept Psychol & Human Dev, 25 Woburn Sq, London WC1H OAA, England.
EM e.midouhas@ioe.ac.uk
RI Charman, Tony/A-2085-2014
OI Charman, Tony/0000-0003-1993-6549
FU UK Economic and Social Research Council [ES/J001414]
FX This article was written while Drs. Midouhas and Flouri were supported
by a grant (ES/J001414) from the UK Economic and Social Research
Council.
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NR 53
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD OCT
PY 2013
VL 52
IS 10
BP 1057
EP 1065
DI 10.1016/j.jaac.2013.07.011
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 230AQ
UT WOS:000325309400010
PM 24074472
ER
PT J
AU Gwynette, MF
AF Gwynette, McLeod Frampton
TI Heterogeneity in Autism Spectrum Disorder(s)
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Letter
ID DSM-5; CRITERIA
C1 Med Univ S Carolina, Charleston, SC USA.
RP Gwynette, MF (reprint author), Med Univ S Carolina, Charleston, SC USA.
EM gwynette@musc.edu
CR Grzadzinski R, 2013, MOL AUTISM, V4, DOI 10.1186/2040-2392-4-12
Huerta M, 2012, AM J PSYCHIAT, V169, P1056, DOI 10.1176/appi.ajp.2012.12020276
King BH, 2013, J AM ACAD CHILD PSY, V52, P454, DOI 10.1016/j.jaac.2013.02.009
McPartland JC, 2012, J AM ACAD CHILD PSY, V51, P368, DOI 10.1016/j.jaac.2012.01.007
NR 4
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD OCT
PY 2013
VL 52
IS 10
BP 1095
EP 1096
DI 10.1016/j.jaac.2013.06.015
PG 2
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 230AQ
UT WOS:000325309400015
PM 24074477
ER
PT J
AU Schmidt, RJ
Tancredi, DJ
Hansen, DRL
Ozonoff, DS
Hertz-Picciotto, I
AF Schmidt, Rebecca J.
Tancredi, D. J.
Hansen, Davis R. L.
Ozonoff, Davis S.
Hertz-Picciotto, Irva
TI Maternal Intake of Supplemental Iron and Risk for Autism Spectrum
Disorders
SO JOURNAL OF WOMENS HEALTH
LA English
DT Meeting Abstract
C1 [Schmidt, Rebecca J.; Tancredi, D. J.] Univ Calif Davis, Dept Publ Hlth Sci, MIND 1, Davis, CA 95616 USA.
[Hansen, Davis R. L.; Ozonoff, Davis S.] Univ Calif Davis, Dept Pediat, MIND 1, Davis, CA 95616 USA.
[Hertz-Picciotto, Irva] Univ Calif Davis, Dept Psychiat & Behav Sci, MIND 1, Davis, CA 95616 USA.
NR 0
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD OCT 1
PY 2013
VL 22
IS 10
BP 897
EP 897
PG 1
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 227TD
UT WOS:000325136500076
ER
PT J
AU Ghosh, A
Michalon, A
Lindemann, L
Fontoura, P
Santarelli, L
AF Ghosh, Anirvan
Michalon, Aubin
Lindemann, Lothar
Fontoura, Paulo
Santarelli, Luca
TI Drug discovery for autism spectrum disorder: challenges and
opportunities
SO NATURE REVIEWS DRUG DISCOVERY
LA English
DT Review
ID FRAGILE-X-SYNDROME; PERVASIVE DEVELOPMENTAL DISORDERS; PLURIPOTENT
STEM-CELLS; DE-NOVO MUTATIONS; TUBEROUS-SCLEROSIS; MOUSE MODEL;
MOLECULAR MEDICINE; NEURAL DEVELOPMENT; LEARNING-DEFICITS; SYNAPTIC
FUNCTION
AB The rising rates of autism spectrum disorder (ASD) and the lack of effective medications to treat its core symptoms have led to an increased sense of urgency to identify therapies for this group of neurodevelopmental conditions. Developing drugs for ASD, however, has been challenging because of a limited understanding of its pathophysiology, difficulties in modelling the disease in vitro and in vivo, the heterogeneity of symptoms, and the dearth of prior experience in clinical development. In the past few years these challenges have been mitigated by considerable advances in our understanding of forms of ASD caused by single-gene alterations, such as fragile X syndrome and tuberous sclerosis. In these cases we have gained insights into the pathophysiological mechanisms underlying these conditions. In addition, they have aided in the development of animal models and compounds with the potential for disease modification in clinical development. Moreover, genetic studies are illuminating the molecular pathophysiology of ASD, and new tools such as induced pluripotent stem cells offer novel possibilities for drug screening and disease diagnostics. Finally, large-scale collaborations between academia and industry are starting to address some of the key barriers to developing drugs for ASD. Here, we propose a conceptual framework for drug discovery in ASD encompassing target identification, drug profiling and considerations for clinical trials in this novel area.
C1 [Ghosh, Anirvan; Michalon, Aubin; Lindemann, Lothar; Fontoura, Paulo; Santarelli, Luca] F Hoffmann La Roche, PRED, Pharma Res & Early Dev, DTA Neurosci, CH-4070 Basel, Switzerland.
RP Ghosh, A (reprint author), F Hoffmann La Roche, PRED, Pharma Res & Early Dev, DTA Neurosci, Grenzacherstr 124, CH-4070 Basel, Switzerland.
EM anirvan.ghosh@roche.com
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NR 86
TC 10
Z9 10
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1474-1776
J9 NAT REV DRUG DISCOV
JI Nat. Rev. Drug Discov.
PD OCT
PY 2013
VL 12
IS 10
BP 777
EP 790
DI 10.1038/nrd4102
PG 14
WC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy
SC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy
GA 227XT
UT WOS:000325149700015
PM 24080699
ER
PT J
AU Harlaar, L
Pouwels, PJ
Geytenbeek, J
Oostrom, K
Barkhof, F
Vermeulen, RJ
AF Harlaar, Laurike
Pouwels, Petra J.
Geytenbeek, Joke
Oostrom, Kim
Barkhof, Frederik
Vermeulen, R. Jeroen
TI Language Comprehension in Young People with Severe Cerebral Palsy in
Relation to Language Tracts: A Diffusion Tensor Imaging Study
SO NEUROPEDIATRICS
LA English
DT Article
DE cerebral palsy; language tracts; magnetic resonance imaging; diffusion
tensor imaging
ID AUTISM SPECTRUM DISORDERS; CHILDREN; IMPAIRMENT; MOTOR
AB Patients with severe cerebral palsy (CP) often have poor speech ability but potentially better language comprehension. The arcuate fasciculus and the extreme capsule are two important language tracts between the Wernicke and Broca areas. Using diffusion tensor imaging, we visualized language tracts and pyramidal tracts in both hemispheres in 10 controls (5 to 18 years) and 5 patients (5 to 23 years) with severe CP. Language comprehension was assessed with a recently designed instrument (the Computer-Based instrument for Low motor Language Testing [C-BiLLT]). The language tracts were visualized in all control children and in four CP patients. In one CP patient without any objective language comprehension skills, no language tract could be visualized. Both language and pyramidal tracts were smaller in patients than in controls. These preliminary data indicate a relation between language tracts and language skills. Further research is necessary to study the value of structural integrity of language tracts in predicting language comprehension in CP patients.
C1 [Harlaar, Laurike; Vermeulen, R. Jeroen] Vrije Univ Amsterdam, Med Ctr, Dept Child Neurol, NL-1007 MB Amsterdam, Netherlands.
[Pouwels, Petra J.] Vrije Univ Amsterdam, Med Ctr, Dept Phys & Med Technol, NL-1007 MB Amsterdam, Netherlands.
[Geytenbeek, Joke] Vrije Univ Amsterdam, Med Ctr, Dept Rehabil, NL-1007 MB Amsterdam, Netherlands.
[Oostrom, Kim] Vrije Univ Amsterdam, Med Ctr, Dept Med Psychol, NL-1007 MB Amsterdam, Netherlands.
[Barkhof, Frederik] Vrije Univ Amsterdam, Med Ctr, Dept Radiol, NL-1007 MB Amsterdam, Netherlands.
RP Vermeulen, RJ (reprint author), Vrije Univ Amsterdam, Med Ctr, Dept Child Neurol, Neurosci Campus Amsterdam,De Boelelaan 1117, NL-1007 MB Amsterdam, Netherlands.
EM rj.vermeulen@vumc.nl
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NR 14
TC 0
Z9 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0174-304X
J9 NEUROPEDIATRICS
JI Neuropediatrics
PD OCT
PY 2013
VL 44
IS 5
BP 286
EP 290
DI 10.1055/s-0033-1341600
PG 5
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 222TR
UT WOS:000324755000010
PM 23564318
ER
PT J
AU Drumm, E
Brian, J
AF Drumm, Ellen
Brian, Jessica
TI The developing language abilities and increased risks of 'unaffected'
siblings of children with autism spectrum disorder
SO NEUROPSYCHIATRY
LA English
DT Review
ID DIAGNOSTIC OBSERVATION SCHEDULE; HIGH-FUNCTIONING CHILDREN;
COMMUNICATION-CHECKLIST; PRAGMATIC LANGUAGE; MULTIPLE-INCIDENCE;
ASPERGER-SYNDROME; FAMILY-HISTORY; DEVELOPMENTAL TRAJECTORIES;
PSYCHIATRIC-DISORDERS; BABY SIBLINGS
AB Siblings of children with autism spectrum disorder (ASD) are at a higher risk than the general population of developing ASD, ASD traits and other developmental differences. A review of prospective longitudinal studies that have followed siblings up to the age of 3 years reveal that siblings with non-ASD outcomes are at increased risk for early language delays; however, there is a dearth of research on language development in these children through to middle childhood. Preliminary research into pragmatics (i.e., the contextually appropriate social use of language) suggests that non-ASD siblings may be at increased risk for impairment in this area, but this is a field that needs further investigation. Understanding the nature of the increased risk for language and related learning challenges in non-ASD siblings of children with ASD is important for researchers, clinicians and parents, as early identification can lead to early intervention and better outcomes.
C1 [Drumm, Ellen; Brian, Jessica] Univ Toronto, Bloorview Res Inst, Toronto, ON M4G 1R8, Canada.
RP Brian, J (reprint author), Univ Toronto, Bloorview Res Inst, 150 Kilgour Rd, Toronto, ON M4G 1R8, Canada.
EM jbrian@hollandbloorview.ca
FU Canadian Institutes of Health Research [276275]
FX This research was supported in part by an award from the Canadian
Institutes of Health Research to E Drumm (funding reference number
276275). The authors have no other relevant affiliations or financial
involvement with any organization or entity with a financial interest in
or financial conflict with the subject matter or materials discussed in
the manuscript apart from those disclosed.
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NR 89
TC 1
Z9 1
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1758-2008
J9 NEUROPSYCHIATRY-LOND
JI Neuropsychiatry
PD OCT
PY 2013
VL 3
IS 5
BP 513
EP 524
DI 10.2217/npy.13.65
PG 12
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 222SG
UT WOS:000324750800015
ER
PT J
AU Dominguez, LG
Stieben, J
Velazquez, JLP
Shanker, S
AF Dominguez, Luis Garcia
Stieben, Jim
Velazquez, Jose Luis Perez
Shanker, Stuart
TI The Imaginary Part of Coherency in Autism: Differences in Cortical
Functional Connectivity in Preschool Children
SO PLOS ONE
LA English
DT Article
ID SPECTRUM DISORDER; PHASE SYNCHRONIZATION; EEG; BRAIN; INDIVIDUALS;
RECORDINGS; COMPLEXITY; NETWORKS; POWER
AB Cognition arises from the transient integration and segregation of activity across functionally distinct brain areas. Autism Spectrum Disorders (ASD), which encompass a wide range of developmental disabilities, have been presumed to be associated with a problem in cortical and sub-cortical dynamics of coordinated activity, often involving enhanced local but decreased long range coordination over areas of integration. In this paper we challenge this idea by presenting results from a relatively large population of ASD children and age-matched controls during a face-processing task. Over most of the explored domain, children with ASD exhibited enhanced synchronization, although finer detail reveals specific enhancement/reduction of synchrony depending on time, frequency and brain site. Our results are derived from the use of the imaginary part of coherency, a measure which is not susceptible to volume conduction artifacts and therefore presents a credible picture of coordinated brain activity. We also present evidence that this measure is a good candidate to provide features in building a classifier to be used as a potential biomarker for autism.
C1 [Dominguez, Luis Garcia] Univ Toronto, Temerty Ctr Therapeut Brain Intervent, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
[Dominguez, Luis Garcia; Stieben, Jim; Shanker, Stuart] York Univ, Milton & Ethel Harris Res Initiat, Toronto, ON M3J 2R7, Canada.
[Velazquez, Jose Luis Perez] Hosp Sick Children, Neurosci & Mental Hlth Programme, Brain & Behaviour Ctr, Div Neurol, Toronto, ON M5G 1X8, Canada.
[Velazquez, Jose Luis Perez] Univ Toronto, Dept Paediat, Toronto, ON M5S 1A1, Canada.
[Velazquez, Jose Luis Perez] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
RP Dominguez, LG (reprint author), Univ Toronto, Temerty Ctr Therapeut Brain Intervent, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
EM l.garcia.d@gmail.com; jstieben@sympatico.ca
FU Harris Steel Foundation; Harris family; Unicorn Foundation; Cure Autism
Now; Public Health Agency of Canada; Templeton Foundation; York
University; facilities of the Shared Hierarchical Academic Research
Computing Network (SHARCNET); Compute/Calcul Canada
FX This research was made possible by the generous support of the Harris
Steel Foundation and the Harris family, which made it possible to create
the Milton and Ethel Harris Research Initiative (www.mehri.ca). The
authors have also received support from the Unicorn Foundation, Cure
Autism Now, the Public Health Agency of Canada, the Templeton
Foundation, York University, and the facilities of the Shared
Hierarchical Academic Research Computing Network (SHARCNET:
www.sharcnet.ca) and Compute/Calcul Canada. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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NR 38
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 1
PY 2013
VL 8
IS 10
AR e75941
DI 10.1371/journal.pone.0075941
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 231OR
UT WOS:000325427100028
ER
PT J
AU Kimura, M
Yamazaki, Y
AF Kimura, Miyako
Yamazaki, Yoshihiko
TI The Lived Experience of Mothers of Multiple Children With Intellectual
Disabilities
SO QUALITATIVE HEALTH RESEARCH
LA English
DT Article
DE children; disability; interpretative phenomenological analysis (IPA);
lived experience; mothers; mothering; research; qualitative
ID PARENTING STRESS; PRESCHOOL-CHILDREN; BEHAVIOR PROBLEMS; DOWN-SYNDROME;
DEVELOPMENTAL-DISABILITIES; MENTAL-HEALTH; AUTISM; COHERENCE; FAMILY;
SENSE
AB In this study, we explored the lived experience of Japanese mothers who have delivered multiple children with intellectual disabilities (ID), using interpretative phenomenological analysis. We identified three superordinate themes and seven subordinate themes from the narrative data collected from 10 participants. The superordinate themes were: abandoned hope for having an ordinary family, accumulating physical and mental fatigue, and searching for positive experiences in parenting multiple children with disabilities. How they perceived the birth of children with disabilities for the second time differed depending on the disability types; specifically, whether they detected the disabilities early or not. Encountering the disability in another child overwhelmed mothers, especially when the disabilities were diagnosed after several years with or without suspicion; they struggled to accept the fact. Despite mothers facing extreme difficulties in parenting multiple children with disabilities, they tried to alter the negative perceptions and find an optimistic way of living.
C1 [Kimura, Miyako] Univ Tokyo, Grad Sch Med, Dept Epidemiol & Prevent Hlth Sci, Bunkyo Ku, Tokyo 1130033, Japan.
[Yamazaki, Yoshihiko] Nihon Fukushi Univ, Fac Social Welf, Mihama, Aichi, Japan.
RP Kimura, M (reprint author), Univ Tokyo, Grad Sch Med, Dept Epidemiol & Prevent Hlth Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.
EM kimurami-tky@umin.ac.jp
CR American Association on Intellectual and Developmental Disabilities, DEF INT DIS
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NR 45
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1049-7323
J9 QUAL HEALTH RES
JI Qual. Health Res.
PD OCT
PY 2013
VL 23
IS 10
SI SI
BP 1307
EP 1319
DI 10.1177/1049732313504828
PG 13
WC Health Policy & Services
SC Health Care Sciences & Services
GA 227ZB
UT WOS:000325153100002
PM 24022734
ER
PT J
AU Corman, MK
AF Corman, Michael K.
TI How Mothers Talk About Placement of Their Child With Autism Outside the
Home
SO QUALITATIVE HEALTH RESEARCH
LA English
DT Article
DE autism; caregivers; caregiving; children; disability; coping and
adaptation; disability; developmental; discourse analysis; families;
caregiving; language; linguistics; mothers; mothering; social
constructionism
ID HIGH-FUNCTIONING AUTISM; DEVELOPMENTAL-DISABILITIES; COPING STRATEGIES;
STRESS PROCESS; DISCOURSE; PARENTS; IDENTITIES; FATHERS; GENDER; ADULTS
AB In this article I use insights offered by the poststructural shift and linguistic turn in social scientific inquiry, specifically discourse analysis, to explore mothers' talk about the placement of their child with autism outside of the home. By viewing mothers' talk as data, I bring to light the discourses and interpretive practices that mothers drew on to organize their talk of placement. In doing so, I provide insights into how mothers gave meaning to processes of placement while also expanding on commonsensical discursive notions of good mothering, caregiving, and family. Implications of the findings are discussed.
C1 Univ Calgary Qatar, Doha, Qatar.
RP Corman, MK (reprint author), Univ Calgary Qatar, POB 23133, Doha, Qatar.
EM mkcorman@ucalgary.ca
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NR 66
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1049-7323
J9 QUAL HEALTH RES
JI Qual. Health Res.
PD OCT
PY 2013
VL 23
IS 10
SI SI
BP 1320
EP 1332
DI 10.1177/1049732313505225
PG 13
WC Health Policy & Services
SC Health Care Sciences & Services
GA 227ZB
UT WOS:000325153100003
PM 24022735
ER
PT J
AU Bartl-Pokorny, KD
Marschik, PB
Sigafoos, J
Tager-Flusberg, H
Kaufmann, WE
Grossmann, T
Einspieler, C
AF Bartl-Pokorny, Katrin D.
Marschik, Peter B.
Sigafoos, Jeff
Tager-Flusberg, Helen
Kaufmann, Walter E.
Grossmann, Tobias
Einspieler, Christa
TI Early socio-communicative forms and functions in typical Rett syndrome
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Family videos; Home videos; Infants; Retrospective analysis; Rett
syndrome; Socio-communicative development; Video analysis
ID PRESERVED SPEECH VARIANT; AUTISM SPECTRUM DISORDER; FRAGILE-X-SYNDROME;
EARLY RECOGNITION; ANGELMAN-SYNDROME; HOME VIDEOTAPES; INDIVIDUALS;
INFANTS; PERSPECTIVE; REGRESSION
AB Rett syndrome (RTT) is a severe neurological disorder characterized by a developmental regression in motor and speech-language domains. There is, however, limited research on socio-communicative development of affected children before the onset of regression. We analyzed audio video recordings made by parents of six 9- to 12-month old girls later diagnosed with typical RTT, applying the Inventory of Potential Communicative Acts (IPCA) to identify early communicative forms and functions. Each girl used at least one communicative form (e.g., body movement, eye gaze, or vocalizations) to gain attention and answer, but none were observed to make choices or request information. Varying numbers of children were observed to perform other communicative functions according to the IPCA including social convention, rejecting or requesting an object. Non-verbal forms (e.g., reaching, moving closer, eye contact, smiling) were more common than non-linguistic verbal forms (e.g., unspecified vocalizations, pleasure vocalizations, crying). (Pre-)linguistic verbal forms (e.g., canonical or variegated babbling, proto-words) were not used for communicative purposes. These data suggest that atypical developmental patterns in the socio-communicative domain are evident prior to regression in young individuals later diagnosed with RTT. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Bartl-Pokorny, Katrin D.; Marschik, Peter B.; Einspieler, Christa] Med Univ Graz, Ctr Physiol Med, Inst Physiol, Res Unit iDN Interdisciplinary Dev Neurosci,IN Sp, Graz, Austria.
[Sigafoos, Jeff] Victoria Univ Wellington, Wellington 6147, New Zealand.
[Tager-Flusberg, Helen] Boston Univ, Dept Psychol, Boston, MA 02215 USA.
[Kaufmann, Walter E.] Boston Childrens Hosp, Boston, MA USA.
[Kaufmann, Walter E.] Harvard Univ, Sch Med, Boston, MA USA.
[Grossmann, Tobias] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany.
RP Sigafoos, J (reprint author), Victoria Univ Wellington, Sch Educ Psychol, POB 17-310, Wellington 6147, New Zealand.
EM jeff.sigafoos@vuw.ac.nz
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NR 47
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3133
EP 3138
DI 10.1016/j.ridd.2013.06.040
PG 6
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500010
PM 23891731
ER
PT J
AU Lydon, S
Healy, O
O'Reilly, M
McCoy, A
AF Lydon, Sinead
Healy, Olive
O'Reilly, Mark
McCoy, Anna
TI A systematic review and evaluation of response redirection as a
treatment for challenging behavior in individuals with developmental
disabilities
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Review
DE Redirection; Response redirection; Response interruption and
redirection; Empirically supported treatment; Evidence-based;
Challenging behavior; Problem behavior; Developmental disabilities;
Automatic reinforcement; Stereotypy
ID EMPIRICALLY SUPPORTED TREATMENT; VOCAL STEREOTYPY; DIFFERENTIAL
REINFORCEMENT; AUTOMATIC REINFORCEMENT; FUNCTIONAL-ANALYSIS;
INTERRUPTION; AUTISM; BLOCKING; PICA; CHILDREN
AB Response redirection is widely used in clinical practice as a treatment for repetitive behavior or stereotypy in persons with developmental disabilities. However, to date the procedure has received comparatively little empirical evaluation. The current review sought to examine the literature describing the efficacy of response redirection alone, response interruption and redirection (RIRD), and multi-element treatment packages incorporating response redirection, as interventions for challenging behavior in individuals with developmental disabilities. Additionally, the status of response redirection, and RIRD, as evidence-based practice was evaluated in accordance with Reichow's (2011) recently developed criteria. Results indicated that interventions involving response redirection or RIRD typically led to large decreases in challenging behavior but did not result in behavioral suppression. On the basis of the current literature and in accordance with Reichow's criteria, interventions incorporating response redirection do not yet constitute evidence-based practice. The implications of these findings, for both research and practice, are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Lydon, Sinead; Healy, Olive; McCoy, Anna] Natl Univ Ireland, Galway, Ireland.
[O'Reilly, Mark] Univ Texas Austin, Meadows Ctr Prevent Educ Risk, Austin, TX 78712 USA.
RP Healy, O (reprint author), Natl Univ Ireland, Sch Psychol, Univ Rd, Galway, Ireland.
EM olive.healy@nuigalway.ie
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Wendt O., 2009, 9 ANN CAMPB COLL C
NR 41
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3148
EP 3158
DI 10.1016/j.ridd.2013.06.010
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500012
PM 23886757
ER
PT J
AU Memari, AH
Ziaee, V
Shayestehfar, M
Ghanouni, P
Mansournia, MA
Moshayedi, P
AF Memari, Amir Hossein
Ziaee, Vahid
Shayestehfar, Monir
Ghanouni, Parisa
Mansournia, Mohammad Ali
Moshayedi, Pouria
TI Cognitive flexibility impairments in children with autism spectrum
disorders: Links to age, gender and child outcomes
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorder; Child outcomes; Cognitive flexibility; Gender
difference; Perseveration
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; EXECUTIVE FUNCTION DEFICITS;
CARD SORTING TEST; SEX-DIFFERENCES; FUNCTIONING AUTISM; ADOLESCENTS;
BEHAVIOR; DOMAINS; PEOPLE; MIND
AB There are still many questions about the cognitive flexibility in autism spectrum disorder (ASD) that remain unanswered. The goal of current study was to evaluate cognitive flexibility patterns and their demographic, clinical and behavioral correlates in large sample of children with ASD. A total of 123 children (94 boys and 29 girls) with ASD aged 7-14 years were assessed on the Wisconsin card sorting test (WCST). Findings showed that gender but not age was associated with the cognitive flexibility performance in ASD. Individuals who had more parent-reported language deficits, lower level of intelligence and education, and showed lower daily sleep time or more engagement in solitary instead of social daily activities were more likely to demonstrate perseveration. Findings provide tentative evidence of a link between cognitive flexibility deficits and sociodemographic or clinical child outcomes in ASD. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Memari, Amir Hossein; Mansournia, Mohammad Ali] Univ Tehran Med Sci, Sports Med Res Ctr, Neurosci Inst, Tehran, Iran.
[Ziaee, Vahid] Univ Tehran Med Sci, Growth & Dev Res Ctr, Tehran, Iran.
[Shayestehfar, Monir; Ghanouni, Parisa] Shahid Beheshti Univ Med Sci, Tehran, Iran.
[Moshayedi, Pouria] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA.
RP Memari, AH (reprint author), Univ Tehran Med Sci, Sports Med Res Ctr, Neurosci Inst, 7 Jalal,POB 14395-578, Tehran, Iran.
EM amirmemari@farabi.tums.ac.ir
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WAINWRIGHTSHARP JA, 1993, J AUTISM DEV DISORD, V23, P1, DOI 10.1007/BF01066415
NR 57
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3218
EP 3225
DI 10.1016/j.ridd.2013.06.033
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500020
PM 23886763
ER
PT J
AU Sun, X
Allison, C
Auyeung, B
Matthews, FE
Baron-Cohen, S
Brayne, C
AF Sun, Xiang
Allison, Carrie
Auyeung, Bonnie
Matthews, Fiona E.
Baron-Cohen, Simon
Brayne, Carol
TI The Mandarin Chinese version of the childhood autism spectrum test
(CAST): Test-retest reliability
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; Screening; Test-retest reliability; CAST; China
ID PERVASIVE DEVELOPMENTAL DISORDERS; ASPERGER-SYNDROME TEST;
SCHOOL-AGE-CHILDREN; HONG-KONG; QUESTIONNAIRE; AGREEMENT; SCALE;
EPIDEMIOLOGY; POPULATION; VALIDATION
AB This study aimed to investigate the test-retest reliability of a Mandarin Chinese version of the Childhood Autism Spectrum Test (CAST), in a Chinese population. Parents in a school based study on the prevalence of ASC in mainland China were asked to complete a second version of the CAST approximately 2-4 months after first completion. Test retest data were available from 70 children (questionnaires completed by the same parent). Using a cut-off score of 15, the test-retest reliability was good (kappa = 0.64). The test-retest reliability in three categories (<= 11, 12-14, >= 15) was moderate (weighted kappa = 0.53). The correlation between the scores at CAST-1 and CAST-2 was good (Spearman rho = 0.73). The Mandarin CAST demonstrated moderate to good test-retest reliability as a screening instrument for ASC in an assessment sample in mainland China. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Sun, Xiang; Brayne, Carol] Univ Cambridge, Cambridge Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge CB2 0SR, England.
[Sun, Xiang; Allison, Carrie; Auyeung, Bonnie; Baron-Cohen, Simon] Univ Cambridge, Autism Res Ctr, Dept Psychiat, Cambridge CB2 2AH, England.
[Matthews, Fiona E.] Univ Cambridge, MRC Biostat Unit, Cambridge Inst Publ Hlth, Cambridge CB2 0SR, England.
RP Sun, X (reprint author), Univ Cambridge, Cambridge Inst Publ Hlth, Dept Publ Hlth & Primary Care, Forvie Site,Robinson Way, Cambridge CB2 0SR, England.
EM xs227@medschl.cam.ac.uk
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NR 44
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3267
EP 3275
DI 10.1016/j.ridd.2013.05.042
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500025
PM 23892873
ER
PT J
AU Dohmen, A
Chiat, S
Roy, P
AF Dohmen, Andrea
Chiat, Shula
Roy, Penny
TI Nonverbal imitation skills in children with specific language delay
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Specific language delay/late talkers; Nonverbal imitation;
Sociocognitive skills; Body movements; Actions on objects
ID DEVELOPMENTAL COORDINATION DISORDER; ELICITED IMITATION; IMPAIRMENT;
AUTISM; GESTURES; HAND; PERFORMANCE; REPETITION; MOVEMENTS; DEFICIT
AB Research in children with language problems has focussed on verbal deficits, and we have less understanding of children's deficits with nonverbal sociocognitive skills which have been proposed to be important for language acquisition. This study was designed to investigate elicited nonverbal imitation in children with specific language delay (SLD). It is argued that difficulties in nonverbal imitation, which do not involve the processing of structural aspects of language, may be indicative of sociocognitive deficits. Participants were German-speaking typically developing children (n = 60) and children with SLD (n = 45) aged 2-31/2 years. A novel battery of tasks measured their ability to imitate a range of nonverbal target acts that to a greater or lesser extent involve sociocognitive skills (body movements, instrumental acts on objects, pretend acts). Significant group differences were found for all body movement and pretend act tasks, but not for the instrumental act tasks. The poorer imitative performance of the SLD sample was not explained by motor or nonverbal cognitive skills. Thus, it appeared that the nature of the task affected children's imitation performance. It is argued that the ability to establish a sense of connectedness with the demonstrator was at the core of children's imitation difficulty in the SLD sample. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Dohmen, Andrea] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England.
[Dohmen, Andrea; Chiat, Shula; Roy, Penny] City Univ London, Language & Commun Sci Div, London EC1V 0HB, England.
RP Dohmen, A (reprint author), Univ Oxford, Dept Expt Psychol, 9 South Parks Rd, Oxford OX1 3UD, England.
EM andrea.dohmen@psy.ox.ac.uk
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NR 55
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3288
EP 3300
DI 10.1016/j.ridd.2013.06.004
PG 13
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500027
PM 23896360
ER
PT J
AU Hsu, CF
AF Hsu, Ching-Fen
TI Contextual integration of causal coherence in people with Williams
syndrome
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Causal inference; Contextual integration; Central coherence; Williams
syndrome
ID FACE; CHILDREN; AUTISM; INFORMATION; PERCEPTION; MIND
AB This study investigated causal coherence in people with Williams syndrome (WS). To advance our understanding of this clinical group, we examined their ability to make causal inferences, using their understanding of homonyms (words with the same spelling but distinct meanings) embedded in contexts. A minor goal was to use verbal stimuli to clarify Santos and Deruelle's (2009) findings on the knowledge of causality among people with WS. Participants were presented with two types of scenarios requiring different inference directions: backward inferences (from consequence to cause) and forward inferences (from cause to consequence). Following each scenario, they were asked a comprehension question and given three possible answers that corresponded to a figurative, literal, and unrelated meaning of the homonym embedded in the scenario. The correct answer required the participants to make a successful causal inference. People with WS aged from 13 to 29 (n = 17, mental age = 6-14) were able to make backward and forward inferences by selecting the context-appropriate meanings of homonyms, thus demonstrating the existence of contextual integration ability in the causal coherence of people with WS. However, as their accuracy in the figurative meaning responses was lower than that of healthy age-matched controls, suggesting the participants with WS, were delayed in the contextual integration of causal coherence. The participants with WS chose a significantly higher percentage of answers with unrelated meanings than the two control groups, indicating a certain degree of weakness in the contextual integration of homonyms in context. (C) 2013 Elsevier Ltd. All rights reserved.
C1 Huafan Univ, Dept Foreign Languages & Literature, Taipei 22301, Taiwan.
RP Hsu, CF (reprint author), Huafan Univ, Dept Foreign Languages & Literature, 1 Huafan Rd, Taipei 22301, Taiwan.
EM chinghsu@cc.hfu.edu.tw
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NR 40
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3332
EP 3342
DI 10.1016/j.ridd.2013.06.031
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500030
PM 23911543
ER
PT J
AU Farran, EK
Cranwell, MB
Alvarez, J
Franklin, A
AF Farran, Emily K.
Cranwell, Matthew B.
Alvarez, James
Franklin, Anna
TI Colour discrimination and categorisation in Williams syndrome
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Williams syndrome; Colour discrimination; Colour categorisation; Visual
perception
ID MUNSELL 100-HUE TEST; VISUAL-SEARCH; LIFE-SPAN; CHILDREN; PERCEPTION;
ABNORMALITIES; DISORDERS; LOCATION; VISION; AUTISM
AB Individuals with Williams syndrome (WS) present with impaired functioning of the dorsal visual stream relative to the ventral visual stream. As such, little attention has been given to ventral stream functions in WS. We investigated colour processing, a predominantly ventral stream function, for the first time in nineteen individuals with Williams syndrome. Colour discrimination was assessed using the Farnsworth-Munsell 100 hue test. Colour categorisation was assessed using a match-to-sample test and a colour naming task. A visual search task was also included as a measure of sensitivity to the size of perceptual colour difference. Results showed that individuals with WS have reduced colour discrimination relative to typically developing participants matched for chronological age; performance was commensurate with a typically developing group matched for nonverbal ability. In contrast, categorisation was typical in WS, although there was some evidence that sensitivity to the size of perceptual colour differences was reduced in this group. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Farran, Emily K.] Univ London, Dept Psychol & Human Dev, Inst Educ, London WC1E 7HU, England.
[Cranwell, Matthew B.] Univ Newcastle, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England.
[Alvarez, James] Univ Surrey, Dept Psychol, Guildford GU2 5XH, Surrey, England.
[Franklin, Anna] Univ Sussex, Sch Psychol, Brighton BN1 9RH, E Sussex, England.
RP Farran, EK (reprint author), Inst Educ, Dept Psychol & Human Dev, 25 Woburn Sq, London WC1H 0AA, England.
EM E.Farran@ioe.ac.uk
RI Farran, Emily/F-6382-2010
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NR 33
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3352
EP 3360
DI 10.1016/j.ridd.2013.06.043
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500032
PM 23911545
ER
PT J
AU Hudry, K
Aldred, C
Wigham, S
Green, J
Leadbitter, K
Temple, K
Barlow, K
McConachie, H
AF Hudry, Kristelle
Aldred, Catherine
Wigham, Sarah
Green, Jonathan
Leadbitter, Kathy
Temple, Kathryn
Barlow, Katherine
McConachie, Helen
CA PACT Consortium
TI Predictors of parent-child interaction style in dyads with autism
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; Parent child interaction; Synchrony; Communication; Shared
attention; Language; Repetitive behavior
ID PERVASIVE DEVELOPMENTAL DISORDERS; YOUNG-CHILDREN; SPECTRUM DISORDERS;
BEHAVIORS; COMMUNICATION; LANGUAGE; RESPONSIVENESS; INTERVENTION;
ATTACHMENT; PARTNER
AB Parent synchrony has been shown to be developmentally important for the growth of communication skills in young children with autism. Understanding individual-differences in parent synchrony and other associated features of dyadic interaction therefore presents as an important step toward the goal of appreciating how and why some parent-child dyads come to adopt more optimal interaction styles, while for others, parent interaction is more asynchronous and less developmentally facilitative. Within the large, well-characterized Preschool Autism Communication Trial (PACT) cohort, baseline parent-child interaction samples were coded for three key aspects of dyadic interaction style; - Parent Synchrony, Child Initiation, and Shared Attention. We explored associations among these measures, demographic characteristics and standardized child assessment scores. While various child factors were associated with each of the interaction measures, very few associations were observed with parent/familial factors. Child language age-equivalence was a significant positive predictor of variation in each interaction measure, while child repetitive symptoms predicted reduced Shared Attention. The three interaction measures were moderately positively inter-related. In the context of childhood autism, variation in dyadic interaction style appears to be driven more by child language and repetitive behaviors than age, social-communication symptoms and non-verbal ability. Parent/family factors contributed little to explaining variability in parent-child interaction, in the current study. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
C1 [Hudry, Kristelle] La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Bundoora, Vic 3086, Australia.
[Aldred, Catherine] Stockport Fdn Trust, NHS, Stockport SK4 1BS, Lancs, England.
[Wigham, Sarah; Temple, Kathryn; Barlow, Katherine; McConachie, Helen] Newcastle Univ, Royal Victoria Infirm, Sir James Spence Inst, Inst Hlth & Soc, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
[Green, Jonathan; Leadbitter, Kathy] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester M13 9PL, Lancs, England.
RP Hudry, K (reprint author), La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Bundoora, Vic 3086, Australia.
EM k.hudry@latrobe.edu.au
RI Byford, Sarah/D-1699-2010; Howlin, Patricia/A-7622-2011; Charman,
Tony/A-2085-2014; Pickles, Andrew/A-9625-2011
OI Byford, Sarah/0000-0001-7084-1495; Charman, Tony/0000-0003-1993-6549;
Pickles, Andrew/0000-0003-1283-0346
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NR 41
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3400
EP 3410
DI 10.1016/j.ridd.2013.07.015
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500037
PM 23911646
ER
PT J
AU Lancioni, GE
Singh, NN
O'Reilly, MF
Sigafoos, J
Oliva, D
Boccasini, A
La Martire, ML
D'Amico, F
Sasanelli, G
AF Lancioni, Giulio E.
Singh, Nirbhay N.
O'Reilly, Mark F.
Sigafoos, Jeff
Oliva, Doretta
Boccasini, Adele
La Martire, Maria L.
D'Amico, Fiora
Sasanelli, Giovanni
TI Persons with multiple disabilities increase adaptive responding and
control inadequate posture or behavior through programs based on
microswitch-cluster technology
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Microswitch-cluster technology; Adaptive responding; Inappropriate
posture; Problem behavior; Multiple disabilities
ID AUTISM SPECTRUM DISORDERS; DEVELOPMENTAL-DISABILITIES; INTELLECTUAL
DISABILITIES; ASSISTIVE TECHNOLOGY; VOCAL STEREOTYPY; EYE POKING;
REDUCE; RESPONSES; CHILDREN; REINFORCEMENT
AB Study I used typical microswitch-cluster programs to promote adaptive responding (i.e., object manipulation) and reduce inappropriate head or head-trunk forward leaning with a boy and a woman with multiple disabilities. Optic, tilt, and vibration microswitches were used to record their adaptive responses while optic and tilt microswitches monitored their posture. The study included an ABB(1)AB(1) sequence, in which A represented baseline phases, B represented an intervention phase in which adaptive responses were always followed by preferred stimulation, and B-1 represented intervention phases in which the adaptive responses led to preferred stimulation only if the inappropriate posture was absent. Study II assessed a non-typical, new microswitch-cluster program to promote two adaptive responses (i.e., mouth cleaning to reduce drooling effects and object assembling) with a man with multiple disabilities. Initially, the man received preferred stimulation for each cleaning response. Then, he received stimulation only if mouth cleaning was preceded by object assembling. The results of Study I showed that both participants had large increases in adaptive responding and a drastic reduction in inappropriate posture during the B-1 phases and a 2-week post-intervention check. The results of Study II showed that the man learned to control drooling effects through mouth cleaning and used object assembling to extend constructive engagement and interspace cleaning responses functionally. The practical implications of the findings are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Lancioni, Giulio E.] Univ Bari, I-70100 Bari, Italy.
[Singh, Nirbhay N.] Georgia Regents Univ, Med Coll Georgia, Augusta, GA USA.
[O'Reilly, Mark F.] Univ Texas Austin, Austin, TX 78712 USA.
[Sigafoos, Jeff] Victoria Univ Wellington, Wellington, New Zealand.
[Oliva, Doretta; Boccasini, Adele; La Martire, Maria L.] Lega F DOro Res Ctr, Osimo, Italy.
[D'Amico, Fiora; Sasanelli, Giovanni] S Raffaele Care Ctr, Alberobello, Italy.
RP Lancioni, GE (reprint author), Univ Bari, Dept Neurosci & Sense Organs, Via Quintino Sella 268, I-70100 Bari, Italy.
EM giulio.lancioni@uniba.it
CR Barlow D., 2009, SINGLE CASE EXPT DES
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NR 56
TC 4
Z9 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3411
EP 3420
DI 10.1016/j.ridd.2013.07.014
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500038
PM 23920024
ER
PT J
AU Beighley, JS
Matson, JL
Rieske, RD
Adams, HL
AF Beighley, Jennifer S.
Matson, Johnny L.
Rieske, Robert D.
Adams, Hilary L.
TI Food selectivity in children with and without an autism spectrum
disorder: Investigation of diagnosis and age
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; Food selectivity; Feeding problems
ID DEVELOPMENTAL-DISABILITIES; ASD-CC; BEHAVIOR; INFANTS; ADULTS; SKILLS;
INTERVENTION; TODDLERS
AB Feeding problems are common in children with autism spectrum disorders (ASDs), with food selectivity being the most frequently reported. Selectivity based on type and/or texture of food is Of concern in those with ASD. Variations in symptom presentation of food selectivity in children with different autism spectrum diagnoses across childhood have not often been investigated. Parent-report of food selectivity was examined in 525 children age 2-18 years diagnosed with autistic disorder, PDD-NOS, Asperger's disorder, atypical development, and typical development using information garnered from the Autism Spectrum Disorder-Comorbidity for Children (ASD-CC), a tool to assess emotional issues and comorbid psychopathology. Individuals with an ASD were reported to have significantly more food selectivity than both the atypically developing group and the typically developing group. In addition, the ASD groups, when looked at together, showed a decrease in food selectivity across childhood with significant decrease in the Asperger's disorder group. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Beighley, Jennifer S.; Matson, Johnny L.; Rieske, Robert D.; Adams, Hilary L.] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Beighley, JS (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM johnmatson@aol.com
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NR 44
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3497
EP 3503
DI 10.1016/j.ridd.2013.07.026
PG 7
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500046
PM 23948127
ER
PT J
AU Sprenger, L
Buhler, E
Poustka, L
Bach, C
Heinzel-Gutenbrunner, M
Kamp-Becker, I
Bachmann, C
AF Sprenger, Linda
Buehler, Eva
Poustka, Luise
Bach, Christiane
Heinzel-Gutenbrunner, Monika
Kamp-Becker, Inge
Bachmann, Christian
TI Impact of ADHD symptoms on autism spectrum disorder symptom severity
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorder; Attention deficit/hyperactivity disorder;
Symptom severity; Psychopathology; Comorbidity
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SOCIAL RESPONSIVENESS SCALE;
PERVASIVE DEVELOPMENTAL DISORDERS; DEFICIT HYPERACTIVITY DISORDER;
CHILD-BEHAVIOR CHECKLIST; DIAGNOSTIC INTERVIEW; FIELD SAMPLE; PDD-NOS;
TRAITS; PSYCHOPATHOLOGY
AB Despite the official exclusion criteria for autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) in the DSM-IV and ICD-10, patients with ASD often show ADHD symptoms. We aimed to examine the potential influence of ADHD symptoms on autistic psychopathology in a large sample of patients with ASD. We tested the hypothesis that patients with ASD and an additional ADHD (ASD+) would show a higher severity of autistic symptoms than those with ASD only (ASD-). We measured autistic symptoms using the autism diagnostic observation schedule (ADOS-G), the autism diagnostic interview (ADI-R), and the social responsiveness scale (SRS). To measure overall psychopathology and ADHD symptoms, we used the child behavior checklist (CBCL) and the ADHD rating scale (FBB-ADHS), respectively. Group differences between the ASD+ and the ASD- group (group division was conducted according to the results of the FBB-ADHS) were calculated using a univariate analysis of variance (ANOVA). The ASD+ group showed a greater severity of autistic symptoms than the ASD- group, measured by the SRS and the ADI-R. Especially in the social interaction subscale (ADI-R), a significantly higher symptom severity was found in the ASD+ group. No significant group differences were found regarding autistic symptoms measured by the ADOS-G. Patients with ASD and an additional ADHD expressed a stronger severity of autistic symptoms than patients with ASD only. According to our results, the possibility of a co-diagnosis of ADS and ADHD, as is being planned in the DSM-5, is in line with earlier studies, is highly reasonable, will simplify research, and have therapeutic implications. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Sprenger, Linda; Bachmann, Christian] Univ Marburg, Fac Human Med, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-35033 Marburg, Germany.
[Buehler, Eva; Heinzel-Gutenbrunner, Monika; Kamp-Becker, Inge; Bachmann, Christian] Charite, Dept Child & Adolescent Psychiat, D-13353 Berlin, Germany.
[Poustka, Luise; Bach, Christiane] Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
RP Sprenger, L (reprint author), Univ Marburg, Fac Human Med, Dept Child & Adolescent Psychiat Psychosomat & Ps, Hans Sachs Str 6, D-35033 Marburg, Germany.
EM linda.sprenger@med.uni-marburg.de; eva.buehler@charite.de;
luise.poustka@zi-mannheim.de; christiane.bach@zi-mannheim.de;
heinzelg@med.uni-marburg.de; kampbeck@med.uni-marburg.de;
cbachman@med.uni-marburg.de
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NR 44
TC 5
Z9 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3545
EP 3552
DI 10.1016/j.ridd.2013.07.028
PG 8
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500051
PM 23973801
ER
PT J
AU Lin, CS
Chang, SH
Liou, WY
Tsai, YS
AF Lin, Chu-Sui
Chang, Shu-Hui
Liou, Wen-Ying
Tsai, Yu-Show
TI The development of a multimedia online language assessment tool for
young children with autism
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Autism; Computer-assisted technology; Language assessment; Hyperlexia
ID SPECTRUM DISORDER; COMPUTER; SKILLS; INSTRUCTION; HYPERLEXIA; VOCABULARY
AB This study aimed to provide early childhood special education professionals with a standardized and comprehensive language assessment tool for the early identification of language learning characteristics (e.g., hyperlexia) of young children with autism. In this study, we used computer technology to develop a multi-media online language assessment tool that presents auditory or visual stimuli. This online comprehensive language assessment consists of six subtests: decoding, homographs, auditory vocabulary comprehension, visual vocabulary comprehension, auditory sentence comprehension, and visual sentence comprehension. Three hundred typically developing children and 35 children with autism from Tao-Yuan County in Taiwan aged 4-6 Participated in this study. The Cronbach alpha values of the six subtests ranged from .64 to .97. The variance explained by the six subtests ranged from 14% to 56%, the current validity of each subtest with the Peabody Picture Vocabulary Test-Revised ranged from .21 to .45, and the predictive validity of each subtest with WISC-III ranged from .47 to .75. This assessment tool was also found to be able to accurately differentiate children with autism up to 92%. These results indicate that this assessment tool has both adequate reliability and validity. Additionally, 35 children with autism have completed the entire assessment in this study without exhibiting any extremely troubling behaviors. However, future research is needed to increase the sample size of both typically developing children and young children with autism and to overcome the technical challenges associated with internet issues. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Lin, Chu-Sui] Chung Yuan Christian Univ, Dept Special Educ, Chungli 32023, Taiwan.
[Chang, Shu-Hui] Chung Yuan Christian Univ, Dept Psychol, Chungli 32023, Taiwan.
[Liou, Wen-Ying] Natl Chia Yi Univ, Dept Educ, Chiayi 600, Taiwan.
[Tsai, Yu-Show] Chung Yuan Christian Univ, Dept Biomed Engn, Chungli 32023, Taiwan.
RP Lin, CS (reprint author), Chung Yuan Christian Univ, Dept Special Educ, 200 Chung Pei Rd, Chungli 32023, Taiwan.
EM chusui@cycu.edu.tw; shuhui@cycu.edu.tw; wengying_l@yahoo.com;
yushow@cycu.edu.tw
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NR 18
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD OCT
PY 2013
VL 34
IS 10
BP 3553
EP 3565
DI 10.1016/j.ridd.2013.06.042
PG 13
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 225NB
UT WOS:000324968500052
PM 23962602
ER
PT J
AU Campbell, CD
Eichler, EE
AF Campbell, Catarina D.
Eichler, Evan E.
TI Properties and rates of germline mutations in humans
SO TRENDS IN GENETICS
LA English
DT Review
DE germline mutation rate; de novo mutation; paternal bias; paternal age;
genome wide
ID COPY-NUMBER VARIATION; ALPHA-SATELLITE DNA; DE-NOVO MUTATIONS; AUTISM
SPECTRUM DISORDERS; HUMAN X-CHROMOSOME; HUMAN GENOME; SEGMENTAL
DUPLICATIONS; HUMAN-DISEASE; INVERSION POLYMORPHISM; STRUCTURAL
VARIATION
AB All genetic variation arises via new mutations; therefore, determining the rate and biases for different classes of mutation is essential for understanding the genetics of human disease and evolution. Decades of mutation rate analyses have focused on a relatively small number of loci because of technical limitations. However, advances in sequencing technology have allowed for empirical assessments of genome-wide rates of mutation. Recent studies have shown that 76% of new mutations originate in the paternal lineage and provide unequivocal evidence for an increase in mutation with paternal age. Although most analyses have focused on single nucleotide variants (SNVs), studies have begun to provide insight into the mutation rate for other classes of variation, including copy number variants (CNVs), microsatellites, and mobile element insertions (MEIs). Here, we review the genome-wide analyses for the mutation rate of several types of variants and suggest areas for future research.
C1 [Campbell, Catarina D.; Eichler, Evan E.] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
[Eichler, Evan E.] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA.
RP Eichler, EE (reprint author), Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
EM eee@gs.washington.edu
FU Ruth L. Kirschstein National Research Service Award (NRSA) [F32HG006070]
FX We thank Santhosh Girirajan and Bradley Coe for sharing data and
figures. We are grateful to Andrew Wilkie, Anne Goriely, and Peter
Sudmant for helpful discussions and to Tonia Brown for assistance with
manuscript preparation. We would like to thank Jacob Michaelson and
Jonathan Sebat for sharing a prepublication version of their manuscript.
C.D.C. was supported by a Ruth L. Kirschstein National Research Service
Award (NRSA; F32HG006070). E.E.E. is an Investigator of the Howard
Hughes Medical Institute.
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NR 120
TC 29
Z9 29
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0168-9525
J9 TRENDS GENET
JI Trends Genet.
PD OCT
PY 2013
VL 29
IS 10
SI SI
BP 575
EP 584
DI 10.1016/j.tig.2013.04.005
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 229XI
UT WOS:000325300800006
PM 23684843
ER
PT J
AU Oksenberg, N
Ahituv, N
AF Oksenberg, Nir
Ahituv, Nadav
TI The role of AUTS2 in neurodevelopment and human evolution
SO TRENDS IN GENETICS
LA English
DT Review
DE AUTS2; autism; neurodevelopment; human evolution
ID AUTISM SPECTRUM DISORDERS; ACUTE LYMPHOBLASTIC-LEUKEMIA; COPY-NUMBER
VARIATION; DE-NOVO MUTATIONS; GENOME-WIDE ASSOCIATION;
AUTISM-SUSCEPTIBILITY-CANDIDATE-2 AUTS2; TRANSLOCATION BREAKPOINT;
DEVELOPING NEOCORTEX; GENE; EXPRESSION
AB The autism susceptibility candidate 2 (AUTS2) gene is associated with multiple neurological diseases, including autism, and has been implicated as an important gene in human-specific evolution. Recent functional analysis of this gene has revealed a potential role in neuronal development. Here, we review the literature regarding AUTS2, including its discovery, expression, association with autism and other neurological and non-neurological traits, implication in human evolution, function, regulation, and genetic pathways. Through progress in clinical genomic analysis, the medical importance of this gene is becoming more apparent, as highlighted in this review, but more work needs to be done to discover the precise function and the genetic pathways associated with AUTS2.
C1 [Ahituv, Nadav] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA.
Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94158 USA.
RP Ahituv, N (reprint author), Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, 1550 4th St, San Francisco, CA 94158 USA.
EM nadav.ahituv@ucsf.edu
FU Simons Foundation [256769]; National Human Genome Research Institute
(NHGRI) [R01HG005058]; National Institute of Child Health and Human
Development (NICHD) [R01HD059862]; National Institute of Neurological
Disorders and Stroke (NINDS) [R01NS079231]; Autism Speaks
FX We would like to thank Christelle Golzio, Nicholas Katsanis, and Erik A.
Sistermans for sharing their work on auts2 including their morpholino
results used in Figure 3C. We would also like to thank members of the
Ahituv lab for helpful comments. NA. and N.O. received support for this
research from the Simons Foundation (SFARI grant 256769 to N.A.),
National Human Genome Research Institute (NHGRI) grant number
R01HG005058, National Institute of Child Health and Human Development
(NICHD) grant number R01HD059862, and National Institute of Neurological
Disorders and Stroke (NINDS) grant number R01NS079231. N.O. is also
supported in part by a Dennis Weatherstone pre-doctoral fellowship from
Autism Speaks.
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NR 79
TC 6
Z9 6
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0168-9525
J9 TRENDS GENET
JI Trends Genet.
PD OCT
PY 2013
VL 29
IS 10
SI SI
BP 600
EP 608
DI 10.1016/j.tig.2013.08.001
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 229XI
UT WOS:000325300800009
PM 24008202
ER
PT J
AU Miller, VM
Zhu, Y
Bucher, C
McGinnis, W
Ryan, LK
Siegel, A
Zalcman, S
AF Miller, V. M.
Zhu, Y.
Bucher, C.
McGinnis, W.
Ryan, L. K.
Siegel, A.
Zalcman, S.
TI Gestational flu exposure induces changes in neurochemicals, affiliative
hormones and brainstem inflammation, in addition to autism-like
behaviors in mice
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Viral exposure; Behavior; Oxytocin; Serotonin; Mice; Dose; Brainstem
ID MATERNAL IMMUNE ACTIVATION; INFLUENZA-VIRUS INFECTION; SPECTRUM
DISORDERS; ENDOTOXIN EXPOSURE; SEX-DIFFERENCES; HOST IMMUNE; RESPONSES;
RATS; SCHIZOPHRENIA; DEPRESSION
AB The prevalence of neurodevelopmental disorders such as autism is increasing, however the etiology of these disorders is unclear and thought to involve a combination of genetic, environmental and immune factors. A recent epidemiological study found that gestational viral exposure during the first trimester increases risk of autism in offspring by twofold. In mice gestational viral exposures alter behavior of offspring, but the biological mechanisms which underpin these behavioral changes are unclear. We hypothesized that gestational viral exposure induces changes in affiliative hormones, brainstem autonomic nuclei and neurotransmitters which are associated with behavioral alterations in offspring. To address this hypothesis, we exposed pregnant mice to influenza A virus (H3N2) on gestational day 9 and determined behavioral, hormonal and brainstem changes in male and female offspring. We found that gestational flu exposure induced dose-dependent alterations in social and aggressive behaviors (p <= 0.05) in male and female offspring and increases in locomotor behaviors particularly in male offspring (p <= 0.05). We found that flu exposure was also associated with reductions in oxytocin and serotonin (p <= 0.05) levels in male and female offspring and sex-specific changes in dopamine metabolism. In addition we found changes in catecholaminergic and microglia density in brainstem tissues of male flu exposed offspring only (p <= 0.05). This study demonstrates that gestational viral exposure induces behavioral changes in mice, which are associated with alterations in affiliative hormones. In addition we found sex-specific changes in locomotor behavior, which may be associated with sex-specific alterations in dopamine metabolism and brainstem inflammation. Further investigations into maternal immune responses are necessary to unravel the molecular mechanisms which underpin abnormal hormonal, immune and behavioral responses in offspring after gestational viral exposure. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Miller, V. M.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12208 USA.
[Miller, V. M.; Bucher, C.] SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, Albany, NY 12201 USA.
[Zhu, Y.; Ryan, L. K.; Siegel, A.; Zalcman, S.] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurol & Neurosci, Newark, NJ 07103 USA.
[Zhu, Y.; Ryan, L. K.; Siegel, A.; Zalcman, S.] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Psychiat, Newark, NJ 07103 USA.
[McGinnis, W.] Autism Res Inst, San Diego, CA 92116 USA.
RP Miller, VM (reprint author), New York State Dept Hlth, Wadsworth Ctr, Clin Med Sci Bldg,New Scotland Ave, Albany, NY 12208 USA.
EM vmiller@wadsworth.org
FU New Jersey Governor's Council on Autism; Autism Research Institute
FX We would like to thank the New Jersey Governor's Council on Autism who
funded the studies by the late Dr. Steven Zalcman and colleagues at the
University of Medicine and Dentistry of New Jersey. We also wish to
thank the Autism Research Institute and Alexander and Bo McInnis who
generously funded Dr. Veronica Miller's neurochemical, hormonal and
pathological analysis of brain tissues. We also thank the Biochemistry
Core and Advanced Light Microscopy Cores at the Wadsworth Center for
their assistance in this study. Finally we thank Ankur Patel, Anthony
Gotay, Praveen Ranganath and Sarah De Asis for their assistance.
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NR 53
TC 4
Z9 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2013
VL 33
BP 153
EP 163
DI 10.1016/j.bbi.2013.07.002
PG 11
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA 223EU
UT WOS:000324788300019
PM 23880236
ER
PT J
AU Richetto, J
Calabrese, F
Meyer, U
Riva, MA
AF Richetto, Juliet
Calabrese, Francesca
Meyer, Urs
Riva, Marco A.
TI Prenatal versus postnatal maternal factors in the development of
infection-induced working memory impairments in mice
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Adoption; Autism; GABA; Glutamic acid decarboxylase; Maternal immune
activation; Poly(I:C); Schizophrenia; Working memory
ID IMMUNE ACTIVATION; DOPAMINERGIC DEVELOPMENT; BRAIN-DEVELOPMENT;
FETAL-BRAIN; SCHIZOPHRENIA; PREGNANCY; CHALLENGE; DYSFUNCTION; EXPOSURE;
BEHAVIOR
AB Prenatal maternal infection is an environmental risk factor for neurodevelopmental psychiatric illness and disease-associated cognitive impairments. Modeling this epidemiological link in animals shows that prenatal immune challenge is capable of inducing long-lasting deficits in numerous cognitive domains. Here, we combined a neonatal cross-fostering design with a mouse model of prenatal immune challenge induced by maternal gestational treatment with the viral mimetic-poly(I:C) to dissect the relative contribution of prenatal and postnatal maternal effects on the offspring. We show that offspring prenatally exposed to poly(I:C) display significant impairments in spatial matching-to-position working memory and spatial novelty presence regardless of whether they are raised by gestationally immune-challenged or non-challenged control surrogate mothers. Likewise, prenatally immune challenged offspring exhibit reduced glutamic acid decarboxylase 65-kDa (GAD(65)) and 67-kDa (GAD(67)) gene expression in the adult medial prefrontal cortex and dorsal hippocampus largely independently of the postnatal rearing conditions. In addition, we confirm that being raised by a gestationally immune-challenged surrogate mother is sufficient to increase the offspring's locomotor response to systemic amphetamine treatment. Our data thus suggest that prenatal infection-induced deficits in spatial short-term memory are mediated by prenatal maternal effects on the offspring. At the same time, our study adds further weight to the notion that being reared by a surrogate mother that experienced immune activation during pregnancy may constitute a risk factor for specific dopaminergic abnormalities. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Richetto, Juliet; Calabrese, Francesca; Riva, Marco A.] Univ Milan, Dipartimento Sci Farmacol & Biomol, Ctr Neuropharmacol, Milan, Italy.
[Meyer, Urs] Swiss Fed Inst Technol, Physiol & Behav Lab, CH-8603 Schwerzenbach, Switzerland.
[Riva, Marco A.] Univ Milan, Ctr Excellence Neurodegenerat Dis, Milan, Italy.
RP Meyer, U (reprint author), Swiss Fed Inst Technol, Physiol & Behav Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland.
EM urs.meyer@ethz.ch
FU European Union's (EU) Seventh Framework Programme (FP7) [259679]; Swiss
National Science Foundation [310030_146217/1]; Italian Ministry of
University and Research [PRIN 20107MSMA4]; Fondazione CARIPLO
[2012-0503]
FX We remain indebted to Ulrike Stadlbauer and Marie Labouesse for animal
husbandry and care. The present study was supported by The European
Union's (EU) Seventh Framework Programme (FP7/2007-2011) under grant
agreement No. 259679 and by the Swiss National Science Foundation (grant
310030_146217/1) awarded to U.M., and by Italian Ministry of University
and Research (PRIN 20107MSMA4) and Fondazione CARIPLO (Grant No.
2012-0503) to M.A.R.
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NR 42
TC 12
Z9 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2013
VL 33
BP 190
EP 200
DI 10.1016/j.bbi.2013.07.006
PG 11
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA 223EU
UT WOS:000324788300023
PM 23876745
ER
PT J
AU Goddard, E
Treasure, J
AF Goddard, E.
Treasure, J.
TI Anxiety and Social-Emotional Processing in Eating Disorders: Examination
of Family Trios
SO COGNITIVE THERAPY AND RESEARCH
LA English
DT Article
DE Eating disorders; Anxiety; Attentional bias; Emotion; Relatives;
Intermediate phenotypes
ID AUTISM SPECTRUM DISORDERS; PROSPECTIVE RISK-FACTORS; STRESS SCALES DASS;
BODY-MASS INDEX; ANOREXIA-NERVOSA; BULIMIA-NERVOSA; PSYCHOMETRIC
PROPERTIES; SELF-REPORT; PERSONALITY-TRAITS; ATTENTIONAL BIASES
AB Anxiety, altered attention for social stimuli and poor recognition of emotions were examined as putative intermediate phenotypes of eating disorders (EDs). Three hundred and forty two participants (65 ED offspring; 52 healthy offspring; 124 parents of ED offspring; 101 parents of healthy offspring) completed self report and behavioural measures of anxiety, attention for social stimuli and emotion recognition. ED offspring and their parents had higher trait anxiety in comparison to healthy controls. Social anxiety co-segregated with the illness in parents. ED offspring did not show Stroop interference for social stimuli. Subtle alterations in response to social stimuli were observed in ED fathers. ED groups did not have difficulties recognising complex emotions. In conclusion, trait and social anxiety fulfil some of the criteria for intermediate phenotypes in EDs. There was less evidence for behavioural measures of anxiety and social processing. This may be a consequence of sample characteristics, low power or task sensitivity.
C1 [Goddard, E.; Treasure, J.] Kings Coll London, Inst Psychiat, Dept Psychol Med, Sect Eating Disorders, London SE5 8AF, England.
RP Goddard, E (reprint author), Kings Coll London, Inst Psychiat, Dept Psychol Med, Sect Eating Disorders, 103 Denmark Hill, London SE5 8AF, England.
EM elizabeth.e.goddard@kcl.ac.uk
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NR 86
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0147-5916
J9 COGNITIVE THER RES
JI Cogn. Ther. Res.
PD OCT
PY 2013
VL 37
IS 5
BP 890
EP 904
DI 10.1007/s10608-013-9535-2
PG 15
WC Psychology, Clinical
SC Psychology
GA 223PD
UT WOS:000324817600002
ER
PT J
AU Crespo, C
Santos, S
Canavarro, MC
Kielpikowski, M
Pryor, J
Feres-Carneiro, T
AF Crespo, Carla
Santos, Susana
Canavarro, Maria Cristina
Kielpikowski, Magdalena
Pryor, Jan
Feres-Carneiro, Terezinha
TI Family routines and rituals in the context of chronic conditions: A
review
SO INTERNATIONAL JOURNAL OF PSYCHOLOGY
LA English
DT Article
DE Routines; Rituals; Family; Chronic condition; Health
ID QUALITY-OF-LIFE; HOUSEHOLD ROUTINES; DIABETES-MELLITUS; CHILDHOOD
ASTHMA; CHRONIC ILLNESS; CHILDREN; AUTISM; MANAGEMENT; ADHERENCE; CANCER
AB This paper is a systematic review of 39 empirical studies on family routines and rituals in the context of a chronic condition of a family member. The search strategy encompassed a wide spectrum of chronic conditions affecting family members from childhood/adolescence to adulthood. Twenty quantitative, 13 qualitative, 3 mixed-methods, and 3 intervention studies published between 1995 and 2012 were reviewed. A conceptual framework of routines and rituals as key elements of family health was adopted, resulting in three main findings. First, a chronic condition in a family member impacted the frequency and nature of family's routines and rituals. Second, these whole-family interactions held important functions for individuals and families, constituting strategic resources in the condition's management and opportunities for emotional support exchanges, and providing the family with a sense of normalcy amid the challenges posed by chronic conditions. Third, family routines and rituals were linked to positive health and adaptation outcomes for both patients and family members. Implications for future research include the need for the distinction between routines and rituals against a conceptual background, use of validated assessment methods, and empirical examination of predictors of changes in routines and rituals throughout the course of the condition and of the mechanisms linking these family events to positive outcomes. Conclusions support the inclusion of routines and rituals in a family-centered care approach to the understanding and treatment of chronic conditions.
C1 [Crespo, Carla; Santos, Susana; Canavarro, Maria Cristina] Univ Coimbra, Fac Psychol & Educ Sci, Coimbra, Portugal.
[Kielpikowski, Magdalena; Pryor, Jan] Victoria Univ Wellington, Roy McKenzie Ctr Study Families, Wellington, New Zealand.
[Feres-Carneiro, Terezinha] Pontifical Catholic Univ Rio de Janeiro, Dept Psychol, Rio De Janeiro, Brazil.
RP Crespo, C (reprint author), Fac Psicol & Ciencias Educ, Rua Colegio Novo,Apartado 6153, P-3001802 Coimbra, Portugal.
EM carlacrespo@fpce.uc.pt
RI Canavarro, Maria Cristina/A-9893-2013
OI Canavarro, Maria Cristina/0000-0002-5083-7322
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NR 63
TC 1
Z9 1
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 0020-7594
J9 INT J PSYCHOL
JI Int. J. Psychol.
PD OCT 1
PY 2013
VL 48
IS 5
BP 729
EP 746
DI 10.1080/00207594.2013.806811
PG 18
WC Psychology, Multidisciplinary
SC Psychology
GA 212QR
UT WOS:000323998400001
PM 23848452
ER
PT J
AU Carter, RD
Raia, M
Ewing-Cobbs, L
Gambello, M
Hashmi, SS
Peterson, SK
Robbins-Furman, P
Potocki, L
AF Carter, Rebecca D.
Raia, Marianna
Ewing-Cobbs, Linda
Gambello, Michael
Hashmi, S. Shahrukh
Peterson, Susan K.
Robbins-Furman, Patricia
Potocki, Lorraine
TI Stress and Well-Being Among Parents of Children with Potocki-Lupski
Syndrome
SO JOURNAL OF GENETIC COUNSELING
LA English
DT Article
DE Parental functioning and coping; Disease severity; Potocki-Lupski
syndrome; Duplication 17p11.2
ID HYPOPLASTIC LEFT-HEART; DUPLICATION 17P11.2; DUP(17)(P11.2P11.2);
DISTRESS; FAMILIES; AUTISM; CANCER
AB Potocki-Lupski syndrome (PTLS) or duplication 17p11.2 syndrome is a newly characterized condition causing a variety of health problems with variable severity, including failure to thrive in infancy and childhood, hypotonia, structural heart anomalies, cognitive impairments, speech and learning difficulties, and autism. Due to its recent clinical characterization little is known about the psychosocial impact of this condition on patients and their families. This study evaluated whether parental psychosocial outcomes were associated with children's PTLS disease severity. Parents of 58 children with PTLS completed a cross-sectional survey that assessed parental stress, quality of life, and coping skills. Parental functioning was associated with greater severity of feeding difficulty and with lower severity of a cardiovascular defect. Findings from this study highlight potential support needs of parents of children affected by PTLS and suggest ways in which these needs may be addressed.
C1 [Carter, Rebecca D.; Robbins-Furman, Patricia] Univ Texas Med Sch Houston, Dept Obstet Gynecol & Reprod Sci, Houston, TX 77030 USA.
[Raia, Marianna] Univ Texas Med Sch Houston, Dept Pediat, Div Med Genet, Houston, TX 77030 USA.
[Ewing-Cobbs, Linda] Univ Texas Med Sch Houston, Childrens Learning Inst, Dept Pediat, Houston, TX 77030 USA.
[Gambello, Michael] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA USA.
[Hashmi, S. Shahrukh] Univ Texas Med Sch Houston, Dept Pediat, Pediat Res Ctr, Houston, TX 77030 USA.
[Peterson, Susan K.] Univ Texas MD Anderson Canc Ctr, Dept Behav Sci, Houston, TX 77030 USA.
[Potocki, Lorraine] Texas Childrens Hosp, Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
RP Carter, RD (reprint author), Univ Texas Med Sch Houston, Dept Obstet Gynecol & Reprod Sci, 6410 Fannin St,Ste 1217, Houston, TX 77030 USA.
EM Rebecca.D.Sample@uth.tmc.edu; lpotocki@bcm.edu
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NR 26
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-7700
J9 J GENET COUNS
JI J. Genet. Couns.
PD OCT
PY 2013
VL 22
IS 5
BP 633
EP 642
DI 10.1007/s10897-013-9602-6
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 219HG
UT WOS:000324496300009
PM 23709095
ER
PT J
AU Hayeems, RZ
Miller, FA
Bytautas, JP
Li, L
AF Hayeems, Robin Z.
Miller, Fiona A.
Bytautas, Jessica P.
Li, Li
TI Does a Duty of Disclosure Foster Special Treatment of Genetic Research
Participants?
SO JOURNAL OF GENETIC COUNSELING
LA English
DT Article
DE Return of research results; Special treatment; Mixed-methods; Autism
spectrum disorders
AB The principle that research participants not receive enhanced care compared to non-participants may be challenged by a duty to disclose genetic research results, especially where care is otherwise inaccessible. Autism researchers' attitudes toward providing enhanced care to study participants were analyzed quantitatively using descriptive and multivariate analyses of survey data and qualitatively through thematic analysis of interview data. Approximately half of survey respondents (n = 168, RR = 44 %) agreed they should provide additional knowledge (52 %) or services (48 %) to study participants that may not be available to non-participants. Qualitatively (n = 23), respondents were motivated by the notion of reciprocity but highlighted tensions when research enables access to expertise and therapeutic resources that are otherwise difficult to obtain. For researchers, feeling obliged to report research results may be in conflict with the obligation to avoid special treatment of research participants; this may in turn threaten principles of voluntariness, autonomy, and justice.
C1 [Hayeems, Robin Z.; Miller, Fiona A.; Bytautas, Jessica P.] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON M5T 3M6, Canada.
[Miller, Fiona A.] Univ Toronto, Joint Ctr Bioeth, Toronto, ON, Canada.
[Li, Li] Univ Toronto, Dept Biostat, Toronto, ON, Canada.
RP Hayeems, RZ (reprint author), Univ Toronto, Inst Hlth Policy Management & Evaluat, 155 Coll St,4th Floor, Toronto, ON M5T 3M6, Canada.
EM robin.hayeems@utoronto.ca
FU Genome Canada; Cystic Fibrosis Canada
FX We thank our study participants for taking the time to complete our
survey and key informant interviews as well as Genome Canada for funding
the two projects from which these data are drawn. We also thank our
clinical collaborators who work in the context of autism spectrum
disorders genetic research (Drs Stephen Scherer, Peter Szatmari, Wendy
Roberts, and Lonny Zweigenbaum). Robin Z Hayeems is supported
Postdoctoral Fellowship from Cystic Fibrosis Canada. Sponsors' support
for this work should not imply endorsement of the conclusions, for which
the authors retain sole responsibility.
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NR 24
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-7700
J9 J GENET COUNS
JI J. Genet. Couns.
PD OCT
PY 2013
VL 22
IS 5
BP 654
EP 661
DI 10.1007/s10897-013-9597-z
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 219HG
UT WOS:000324496300011
PM 23681280
ER
PT J
AU Wang, KS
Liu, XF
Arana, TB
Thompson, N
Weisman, H
Devargas, C
Mao, CX
Bin Su, B
Camarillo, C
Escamilla, MA
Xu, C
AF Wang, Ke-Sheng
Liu, Xuefeng
Arana, Tania Bedard
Thompson, Nicholas
Weisman, Henry
Devargas, Cecilia
Mao, ChunXiang
Bin Su, Brenda
Camarillo, Cynthia
Escamilla, Michael A.
Xu, Chun
TI Genetic Association Analysis of ITGB3 Polymorphisms with Age at Onset of
Schizophrenia
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Schizophrenia; Integrin-beta 3 subunit gene (ITGB3) gene; 17q21.32; Age
at onset; Meta-analysis; Single-nucleotide polymorphisms
ID GENOME-WIDE ASSOCIATION; CANDIDATE GENES; DISORDERS; ANTIPSYCHOTICS;
ENDOPHENOTYPES; METAANALYSIS; APOPTOSIS; DISEASE; LINKAGE; AUTISM
AB Schizophrenia (SCZ) is a debilitating disorder with a prevalence of approximately 1 % worldwide. SCZ is known to have a high degree of genetic and clinical heterogeneity and is a major health problem worldwide. The integrin-beta 3 subunit gene (ITGB3) gene at 17q21.32 has been implicated in psychiatric disorders. We therefore hypothesized that ITGB3 gene polymorphisms might also play a role in SCZ and age at onset (AAO) of SCZ. We investigated the genetic associations of 23 single-nucleotide polymorphisms (SNPs) of the ITGB3 gene with AAO in SCZ in two Caucasian samples (2,166 cases and 2,525 controls) using linear regression analysis and meta-analysis. We observed four ITGB3-SNPs associated with AAO in SCZ in a non-Genetic Association Information Network (GAIN) sample (p < 10(-3)). Three of these four SNPs were replicated in the GAIN sample. The SNP rs16941771 was most significantly associated with AAO (p = 7.47 x 10(-5)). Meta-analysis showed that 6 of 23 SNPs were associated with AAO. The haplotype analysis also supports the association of ITGB3 with AAO. Three disease-associated SNPs were located at species-conserved regions, indicating functional importance. This is the first report which shows that ITGB3 variants are associated with AAO in SCZ, providing direct evidence of the use of AAO as an intermediate phenotype to dissect the complex genetics of SCZ.
C1 [Arana, Tania Bedard; Weisman, Henry; Devargas, Cecilia; Camarillo, Cynthia; Escamilla, Michael A.; Xu, Chun] Texas Tech Univ, Hlth Sci Ctr, Dept Psychiat, El Paso, TX 79905 USA.
[Arana, Tania Bedard; Weisman, Henry; Devargas, Cecilia; Camarillo, Cynthia; Escamilla, Michael A.; Xu, Chun] Texas Tech Univ, Hlth Sci Ctr, Dept Neurol, El Paso, TX USA.
[Arana, Tania Bedard; Camarillo, Cynthia; Escamilla, Michael A.; Xu, Chun] Texas Tech Univ, Hlth Sci Ctr, Ctr Excellence Neurosci, El Paso, TX USA.
[Thompson, Nicholas] Texas Tech Univ, Hlth Sci Ctr, El Paso, TX USA.
[Wang, Ke-Sheng; Liu, Xuefeng] E Tennessee State Univ, Coll Publ Hlth, Dept Biostat & Epidemiol, Johnson City, TN 37614 USA.
[Bin Su, Brenda; Xu, Chun] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin 150086, Peoples R China.
[Mao, ChunXiang] Univ Toronto, Toronto, ON, Canada.
RP Xu, C (reprint author), Texas Tech Univ, Hlth Sci Ctr, Dept Psychiat, El Paso, TX 79905 USA.
EM wangk@etsu.edu; chunxu10@gmail.com
FU NIH [5U01M0H79469]; Genome-Wide Association Study of Schizophrenia
(GAIN); Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_
nonGAIN); Genomics Research Branch at NIMH
FX Funding support for Genome-Wide Association Study of Schizophrenia was
providedby funding from the NIH grant 5U01M0H79469 to Dr. PV Gejman and
the genotyping of samples was provided through the Genetic Association
Information Network (GAIN). The dataset used for the analyses described
in this manuscript were obtained from the database of Genotype and
Phenotype (dbGaP) found at http://www.ncbi.nlm.nih.gov/gap through dbGaP
accession number phs000021.v2.p1. Samples and associated phenotype data
for the Genome-Wide Association Study of Schizophrenia were provided by
Dr. PV Gejman. Funding support for the companion studies, Genome-Wide
Association Study of Schizophrenia (GAIN) and Molecular Genetics of
Schizophrenia - nonGAIN Sample (MGS_ nonGAIN), was provided by Genomics
Research Branch at NIMH and the genotyping and analysis of samples was
provided through the Genetic Association Information Network (GAIN) and
under the MGS U01s: MH79469 and MH79470. Assistance with data cleaning
wasprovided by the National Center for Biotechnology Information. The
MGS dataset(s) used for the analyses described in this manuscript were
obtained from the database of Genotype and Phenotype (dbGaP) found at
http://www.ncbi.nlm.nih.gov/gap through dbGaP accession numbers
phs000021.v2.p1 (GAIN) and phs000167.v1.p1(nonGAIN). Samples and
associated phenotype data for the MGS GWAS study werecollected under the
following grants: NIMH Schizophrenia Genetics Initiative U01s: MH46276
(CR Cloninger), MH46289 (C Kaufmann), and MH46318 (MT Tsuang); andMGS
Part 1 (MGS1) and Part 2 (MGS2) R01s: MH67257 (NG Buccola), MH59588
(BJMowry), MH59571 (PV Gejman), MH59565 (Robert Freedman), MH59587 (F
Amin), MH60870 (WF Byerley), MH59566 (DW Black), MH59586 (JM Silverman),
MH61675(DF Levinson), and MH60879 (CR Cloninger). Further details of
collection sites, individuals, and institutions may be found in data
supplement Table 1 of Sanders et al. (2008).
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NR 35
TC 0
Z9 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD OCT
PY 2013
VL 51
IS 2
BP 446
EP 453
DI 10.1007/s12031-013-0059-8
PG 8
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 221DG
UT WOS:000324637200027
PM 23860687
ER
PT J
AU Sullivan, PF
AF Sullivan, P. F.
TI Questions about DISC1 as a genetic risk factor for schizophrenia
SO MOLECULAR PSYCHIATRY
LA English
DT Editorial Material
ID DE-NOVO MUTATIONS; BIPOLAR DISORDER; TRANSLOCATION; ASSOCIATION;
LINKAGE; FAMILY; AUTISM; METAANALYSIS; VARIANTS; PATTERNS
C1 Univ N Carolina, Ctr Psychiat Genom, Dept Genet & Psychiat, Chapel Hill, NC 27515 USA.
RP Sullivan, PF (reprint author), Univ N Carolina, Ctr Psychiat Genom, Dept Genet & Psychiat, Chapel Hill, NC 27515 USA.
EM pfsulliv@med.unc.edu
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NR 31
TC 14
Z9 14
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD OCT
PY 2013
VL 18
IS 10
BP 1050
EP 1052
DI 10.1038/mp.2012.182
PG 3
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 222JJ
UT WOS:000324726700002
PM 24056909
ER
PT J
AU Ben-David, E
Shifman, S
AF Ben-David, E.
Shifman, S.
TI Combined analysis of exome sequencing points toward a major role for
transcription regulation during brain development in autism
SO MOLECULAR PSYCHIATRY
LA English
DT Letter
ID DE-NOVO MUTATIONS; SPECTRUM
C1 [Ben-David, E.; Shifman, S.] Hebrew Univ Jerusalem, Inst Life Sci, Dept Genet, IL-91904 Jerusalem, Israel.
RP Ben-David, E (reprint author), Hebrew Univ Jerusalem, Inst Life Sci, Dept Genet, IL-91904 Jerusalem, Israel.
EM sagiv@vms.huji.ac.il
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NR 8
TC 19
Z9 20
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD OCT
PY 2013
VL 18
IS 10
BP 1054
EP 1056
DI 10.1038/mp.2012.148
PG 4
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 222JJ
UT WOS:000324726700004
PM 23147383
ER
PT J
AU Sowers, LP
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Shepherd, AJ
Ferguson, PJ
Darbro, BW
Richerson, GB
Mohapatra, DP
Wemmie, JA
Bassuk, AG
AF Sowers, L. P.
Loo, L.
Wu, Y.
Campbell, E.
Ulrich, J. D.
Wu, S.
Paemka, L.
Wassink, T.
Meyer, K.
Bing, X.
El-Shanti, H.
Usachev, Y. M.
Ueno, N.
Manak, R. J.
Shepherd, A. J.
Ferguson, P. J.
Darbro, B. W.
Richerson, G. B.
Mohapatra, D. P.
Wemmie, J. A.
Bassuk, A. G.
TI Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like
behaviors with evidence for hippocampal synaptic dysfunction
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE autism; learning; memory; planar cell polarity; Wnt
ID DE-NOVO MUTATIONS; PLANAR CELL POLARITY; SPECTRUM DISORDERS;
SOCIAL-INTERACTION; MOUSE PRICKLE1; MICE; EPILEPSY; NEURONS;
DIFFERENTIATION; ABNORMALITIES
AB Autism spectrum disorders (ASDs) have been suggested to arise from abnormalities in the canonical and non-canonical Wnt signaling pathways. However, a direct connection between a human variant in a Wnt pathway gene and ASD-relevant brain pathology has not been established. Prickle2 (Pk2) is a post-synaptic non-canonical Wnt signaling protein shown to interact with post-synaptic density 95 (PSD-95). Here, we show that mice with disruption in Prickle2 display behavioral abnormalities including altered social interaction, learning abnormalities and behavioral inflexibility. Prickle2 disruption in mouse hippocampal neurons led to reductions in dendrite branching, synapse number and PSD size. Consistent with these findings, Prickle2 null neurons show decreased frequency and size of spontaneous miniature synaptic currents. These behavioral and physiological abnormalities in Prickle2 disrupted mice are consistent with ASD-like phenotypes present in other mouse models of ASDs. In 384 individuals with autism, we identified two with distinct, heterozygous, rare, non-synonymous PRICKLE2 variants (p.E8Q and p.V153I) that were shared by their affected siblings and inherited paternally. Unlike wild-type PRICKLE2, the PRICKLE2 variants found in ASD patients exhibit deficits in morphological and electrophysiological assays. These data suggest that these PRICKLE2 variants cause a critical loss of PRICKLE2 function. The data presented here provide new insight into the biological roles of Prickle2, its behavioral importance, and suggest disruptions in non-canonical Wnt genes such as PRICKLE2 may contribute to synaptic abnormalities underlying ASDs.
C1 [Sowers, L. P.; Campbell, E.; Wu, S.; Paemka, L.; Bing, X.; Ferguson, P. J.; Darbro, B. W.; Richerson, G. B.; Bassuk, A. G.] Univ Iowa, Dept Pediat, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA.
[Sowers, L. P.; Manak, R. J.; Richerson, G. B.; Bassuk, A. G.] Univ Iowa, Interdisciplinary Grad Program Mol & Cellular Bio, Iowa City, IA 52242 USA.
[Loo, L.; Ulrich, J. D.; Usachev, Y. M.; Shepherd, A. J.; Mohapatra, D. P.] Univ Iowa, Dept Pharmacol, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA.
[Wu, Y.; Richerson, G. B.] Univ Iowa, Dept Neurol, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA.
[Paemka, L.; Manak, R. J.; Bassuk, A. G.] Univ Iowa, Interdisciplinary Grad Program Genet, Iowa City, IA 52242 USA.
[Wassink, T.; Meyer, K.; Wemmie, J. A.] Univ Iowa, Dept Psychiat, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA.
[El-Shanti, H.] Shafallah Med Genet Ctr, Doha, Qatar.
[Usachev, Y. M.; Richerson, G. B.; Mohapatra, D. P.; Wemmie, J. A.; Bassuk, A. G.] Univ Iowa, Interdisciplinary Grad Program Neurosci, Iowa City, IA 52242 USA.
[Ueno, N.] Natl Inst Basic Biol, Div Morphogenesis, Okazaki, Aichi 444, Japan.
[Manak, R. J.] Univ Iowa, Dept Biol, Iowa City, IA 52242 USA.
RP Bassuk, AG (reprint author), Univ Iowa, Dept Pediat, 2160 Med Labs,25 South Grand Ave, Iowa City, IA 52242 USA.
EM alexander-bassuk@uiowa.edu
FU NIH [1R01 NS064159-01A1]; University of Iowa ICTS pilot-award
FX Thanks to Dr Margaret Price, Michael Lutter, Jeff Murray, Mathew State
and Dr Vinu Mahajan for comments and insights regarding the paper.
Thanks to Chantal Allamargot and Jean Ross in the University of Iowa
Microscopy core for their technical assistance. This work was supported
by NIH grant 1R01 NS064159-01A1 and a University of Iowa ICTS
pilot-award (AGB).
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NR 61
TC 8
Z9 8
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD OCT
PY 2013
VL 18
IS 10
BP 1077
EP 1089
DI 10.1038/mp.2013.71
PG 13
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 222JJ
UT WOS:000324726700008
PM 23711981
ER
PT J
AU Moreno-De-Luca, D
Sanders, SJ
Willsey, AJ
Mulle, JG
Lowe, JK
Geschwind, DH
State, MW
Martin, CL
Ledbetter, DH
AF Moreno-De-Luca, D.
Sanders, S. J.
Willsey, A. J.
Mulle, J. G.
Lowe, J. K.
Geschwind, D. H.
State, M. W.
Martin, C. L.
Ledbetter, D. H.
TI Using large clinical data sets to infer pathogenicity for rare copy
number variants in autism cohorts
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE autism; chromosomal microarray; copy number variant; deletion;
duplication; pathogenic
ID HIDDEN-MARKOV MODEL; SNP GENOTYPING DATA; SPECTRUM DISORDERS; CHROMOSOME
16P11.2; GENETICS; GENOME; SCHIZOPHRENIA; ABNORMALITIES; DUPLICATIONS;
DELETIONS
AB Copy number variants (CNVs) have a major role in the etiology of autism spectrum disorders (ASD), and several of these have reached statistical significance in case-control analyses. Nevertheless, current ASD cohorts are not large enough to detect very rare CNVs that may be causative or contributory (that is, risk alleles). Here, we use a tiered approach, in which clinically significant CNVs are first identified in large clinical cohorts of neurodevelopmental disorders (including but not specific to ASD), after which these CNVs are then systematically identified within well-characterized ASD cohorts. We focused our initial analysis on 48 recurrent CNVs (segmental duplication-mediated 'hotspots') from 24 loci in 31 516 published clinical cases with neurodevelopmental disorders and 13 696 published controls, which yielded a total of 19 deletion CNVs and 11 duplication CNVs that reached statistical significance. We then investigated the overlap of these 30 CNVs in a combined sample of 3955 well-characterized ASD cases from three published studies. We identified 73 deleterious recurrent CNVs, including 36 deletions from 11 loci and 37 duplications from seven loci, for a frequency of 1 in 54; had we considered the ASD cohorts alone, only 58 CNVs from eight loci (24 deletions from three loci and 34 duplications from five loci) would have reached statistical significance. In conclusion, until there are sufficiently large ASD research cohorts with enough power to detect very rare causative or contributory CNVs, data from larger clinical cohorts can be used to infer the likely clinical significance of CNVs in ASD.
C1 [Moreno-De-Luca, D.; Martin, C. L.] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA.
[Moreno-De-Luca, D.; Sanders, S. J.; Willsey, A. J.; State, M. W.] Yale Univ, Sch Med, Ctr Child Study, Program Neurogenet, New Haven, CT 06510 USA.
[Moreno-De-Luca, D.; Sanders, S. J.; Willsey, A. J.; State, M. W.] Yale Univ, Sch Med, Ctr Child Study, Program Human Genet & Genom, New Haven, CT 06510 USA.
[Moreno-De-Luca, D.; Sanders, S. J.; Willsey, A. J.; State, M. W.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
[Moreno-De-Luca, D.; Sanders, S. J.; Willsey, A. J.; State, M. W.] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA.
[Mulle, J. G.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Lowe, J. K.; Geschwind, D. H.] Univ Calif Los Angeles, Neurogenet Program, Los Angeles, CA USA.
[Ledbetter, D. H.] Geisinger Hlth Syst, Genom Med Inst, Danville, PA USA.
RP Moreno-De-Luca, D (reprint author), Emory Univ, Sch Med, Dept Human Genet, 615 Michael St,Suite 315, Atlanta, GA 30322 USA.
EM daniel.morenodeluca@yale.edu; dhledbetter@geisinger.edu
FU National Institutes of Health [MH081754, MH074090]; Simons Foundation
[SFARI 124827]; National Institute of Mental Health [1U24MH081810]
FX We would like to thank the families and the investigators for their
participation in the clinical, ASD, and control collections we used for
this study. We also thank DJ Cutler for expert statistical advice, CT
Strauss for editorial assistance and EB Kaminsky and A Moreno-De-Luca
for critical review of the manuscript. This work was funded in part by
National Institutes of Health grants MH081754 (DHG, CLM) and MH074090
(DHL, CLM) and by a grant from the Simons Foundation (SFARI 124827 to
CLM, MS). We acknowledge support from AGRE and autism speaks.We also
acknowledge the resources provided by the AGRE Consortium (D Geschwind,
M Bucan, W Brown, R Cantor, J Constantino, T Gilliam, M Herbert, C
Lajonchere, D Ledbetter, C Martin, J Miller, S Nelson, G Schellenberg, C
Samango-Sprouse, S Spence, M State, R Tanzi). The AGRE is a program of
autism speaks and is supported, in part, by grant 1U24MH081810 from the
National Institute of Mental Health to Clara M Lajonchere (PI). Approved
researchers can obtain the AGRE population data set described in this
study by applying online at http://research.agre.org/. We are also
grateful to the principal investigators of the SSC (A Beaudet, R
Bernier, J Constantino, E Cook, E Fombonne, D Geschwind, R Goin-Kochel,
E Hanson, D Grice, A Klin, D Ledbetter, C Lord, C Martin, D Martin, R
Maxim, J Miles, O Ousley, K Pelphrey, B Peterson, J Piggot, C Saulnier,
M State, W Stone, J Sutcliffe, C Walsh, Z Warren, E Wijsman). We
appreciate obtaining access to phenotypic data on SFARI Base. Approved
researchers can obtain the SSC population data set described in this
study by applying online at https://base.sfari.org.
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NR 29
TC 17
Z9 18
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD OCT
PY 2013
VL 18
IS 10
BP 1090
EP 1095
DI 10.1038/mp.2012.138
PG 6
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 222JJ
UT WOS:000324726700009
PM 23044707
ER
PT J
AU Gao, C
Tronson, NC
Radulovic, J
AF Gao, Can
Tronson, Natalie C.
Radulovic, Jelena
TI Modulation of behavior by scaffolding proteins of the post-synaptic
density
SO NEUROBIOLOGY OF LEARNING AND MEMORY
LA English
DT Article
DE Glutamate receptor; Scaffold; Behavior; Psychiatric disorders
ID LONG-TERM POTENTIATION; METABOTROPIC GLUTAMATE RECEPTORS; DENDRITIC
SPINE MORPHOGENESIS; AUTISM SPECTRUM DISORDERS; GTPASE-ACTIVATING
PROTEIN; NULL MUTANT MICE; NMDA RECEPTOR; SYNAPTIC PLASTICITY;
MENTAL-RETARDATION; KNOCKOUT MICE
AB Scaffolding proteins of the neuronal post-synaptic density (PSD) are principal organizers of glutamatergic neurotransmission that bring together glutamate receptors and signaling molecules at discrete synaptic locations. Genetic alterations of individual PSD scaffolds therefore disrupt the function of entire multiprotein modules rather than a single glutamatergic mechanism, and thus induce a range of molecular and structural abnormalities in affected neurons. Despite such broad molecular consequences, knockout, knockdown, or knockin of glutamate receptor scaffolds typically affect a subset of specific behaviors and thereby mold and specialize the actions of the ubiquitous glutamatergic neurotransmitter system. Approaches designed to control the function of neuronal scaffolds may therefore have high potential to restore behavioral morbidities and comorbidities in patients with psychiatric disorders. Here we summarize a series of experiments with genetically modified mice revealing the roles of main N-methyl-D-aspartate (NMDA) and group I metabotropic glutamate (mGluR1/5) receptor scaffolds in behavior, discuss the clinical implications of the findings, and propose future research directions. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Gao, Can] Xuzhou Med Coll, Jiangsu Key Lab Anesthesiol, Xuzhou 221004, Jiangsu, Peoples R China.
[Tronson, Natalie C.] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
[Radulovic, Jelena] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
RP Gao, C (reprint author), Xuzhou Med Coll, Jiangsu Key Lab Anesthesiol, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China.
EM gaocan@xzmc.edu.cn; j-radulovic@northwestern.edu
FU NIMH [R01MH078064]
FX The authors thank Dan Sylvester for assistance with the preparation of
the manuscript and Dr. Ted Abel for the invitation to contribute to this
special issue. This work was supported by NIMH R01MH078064 to JR.
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NR 134
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1074-7427
EI 1095-9564
J9 NEUROBIOL LEARN MEM
JI Neurobiol. Learn. Mem.
PD OCT
PY 2013
VL 105
SI SI
BP 3
EP 12
DI 10.1016/j.nlm.2013.04.014
PG 10
WC Behavioral Sciences; Neurosciences; Psychology; Psychology,
Multidisciplinary
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 219LP
UT WOS:000324508800002
PM 23701866
ER
PT J
AU Nylander, L
Holmqvist, M
Gustafson, L
Gillberg, C
AF Nylander, Lena
Holmqvist, Maria
Gustafson, Lars
Gillberg, Christopher
TI Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum
disorder (ASD) in adult psychiatry. A 20-year register study
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE ADHD; Adult psychiatry; Autism spectrum disorder
ID DEFICIT HYPERACTIVITY DISORDER; COMORBIDITY; POPULATION; PREVALENCE
AB Objective: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are increasingly recognized in adults. This study aimed to assess trends in diagnostic practice, diagnostic delay and comorbidity regarding ADHD and ASD in adult psychiatric patients. Methods: Individuals with diagnosed ADHD or ASD were identified in an adult psychiatry register comprising 56,462 patients. Results: ADHD was diagnosed in up to 2.7% and ASD in 1.3% of the patients. Most cases were diagnosed within 2 years of first contact with adult psychiatry, but some patients were treated for 10 years or more before being diagnosed with ADHD or ASD. Seventy per cent of ADHD and 56% of ASD patients were treated as outpatients only. Other psychiatric diagnoses were registered in about 60%. Affective disorders were common in patients with ADHD. Psychoses and intellectual disability were more common in ASD patients. Psychoactive substance use-related disorders were considerably more common in those with ADHD. Concomitant ADHD and ASD were seldom diagnosed in this clinical material. Conclusion: ADHD and ASD were probably much underdiagnosed in the studied group of psychiatric patients. Other psychiatric diagnoses were common, but not ADHD with concomitant ASD.
C1 [Nylander, Lena] Lund Univ, Dept Clin Sci Psychiat, S-22100 Lund, Sweden.
[Nylander, Lena; Gillberg, Christopher] Gothenburg Univ, Gillberg Neuropsychiat Ctr, S-41124 Gothenburg, Sweden.
[Holmqvist, Maria] Univ Lund Hosp, Adult Psychiat Clin, Lund, Sweden.
[Gustafson, Lars] Lund Univ, Dept Clin Sci Psychogeriatr, S-22100 Lund, Sweden.
RP Nylander, L (reprint author), MS S T Lars 1 Tr Korr A, S-22185 Lund, Sweden.
EM lena.nylander@skane.se
FU Ellen och Henrik Sjobrings Minnesfond, Lund, Sweden; Region Skane, Lund,
Sweden; Swedish Science Council, Stockholm, Sweden
FX Financial support for this research was provided by grants from Ellen
och Henrik Sjobrings Minnesfond, Lund, Sweden, grants for doctoral
studies from Region Skane, Lund, Sweden, and grants to professor
Gillberg from the Swedish Science Council, Stockholm, Sweden.
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NR 29
TC 4
Z9 4
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0803-9488
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD OCT
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IS 5
BP 344
EP 350
DI 10.3109/08039488.2012.748824
PG 7
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SC Psychiatry
GA 223BA
UT WOS:000324776900009
PM 23234539
ER
PT J
AU Das, UN
AF Das, Undurti N.
TI Autism as a disorder of deficiency of brain-derived neurotrophic factor
and altered metabolism of polyunsaturated fatty acids
SO NUTRITION
LA English
DT Review
DE Autism; Polyunsaturated fatty acids; Brain-derived neurotrophic factor;
Inflammation; Cytokines; Lipoxins; Resolvins; Prostaglandins; Memory;
Nitric oxide
ID LONG-TERM POTENTIATION; NECROSIS-FACTOR-ALPHA; GLIAL TNF-ALPHA;
DOCOSAHEXAENOIC ACID; NITRIC-OXIDE; SPECTRUM DISORDERS;
ARACHIDONIC-ACID; OXIDATIVE STRESS; FOLIC-ACID; SYNAPTIC-TRANSMISSION
AB Autism has a strong genetic and environmental basis in which inflammatory markers and factors concerned with synapse formation, nerve transmission, and information processing such as brain-derived neurotrophic factor (BDNF), polyunsaturated fatty acids (PUFAs): arachidonic (AA), eicosapentaenoic (EPA), and docosahexaenoic acids (DHA) and their products and neurotransmitters: dopamine, serotonin, acetylcholine, gamma-aminobutyric acid, and catecholamines and cytokines are altered. Antioxidants, vitamins, minerals, and trace elements are needed for the normal metabolism of neurotrophic factors, eicosanoids, and neurotransmitters, supporting reports of their alterations in autism. But, the exact relationship among these factors and their interaction with genes and proteins concerned with brain development and growth is not clear. It is suggested that maternal infections and inflammation and adverse events during intrauterine growth of the fetus could lead to alterations in the gene expression profile and proteomics that results in dysfunction of the neuronal function and neurotransmitters, alteration(s) in the metabolism of PUFAs and their metabolites resulting in excess production of proinflammatory eicosanoids and cytokines and a deficiency of anti-inflammatory cytokines and bioactive lipids that ultimately results in the development of autism. Based on these evidences, it is proposed that selective delivery of BDNF and methods designed to augment the production of anti-inflammatory cytokines and eicosanoids and PUFAs may prevent, arrest, or reverse the autism disease process. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Das, Undurti N.] UND Life Sci, Shaker Hts, OH USA.
[Das, Undurti N.] Jawaharlal Nehru Technol Univ, Kakinada, India.
[Das, Undurti N.] Gayatri Vidya Parishad Coll Engn, BioSci Res Ctr, Visakhapatnam, Andhra Pradesh, India.
RP Das, UN (reprint author), UND Life Sci, Shaker Hts, OH USA.
EM Undurti@hotmail.com
FU Department of Biotechnology; Defense Research and Development
Organization (DRDO), New Delhi
FX Dr. Das was in receipt of Ramalingaswami Fellowship of the Department of
Biotechnology during the tenure of this study. This work was supported
by a grant from Defense Research and Development Organization (DRDO),
New Delhi.
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NR 138
TC 8
Z9 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD OCT
PY 2013
VL 29
IS 10
BP 1175
EP 1185
DI 10.1016/j.nut.2013.01.012
PG 11
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 223DS
UT WOS:000324784900001
PM 23911220
ER
PT J
AU Rattaz, C
Dubois, A
Michelon, C
Viellard, M
Poinso, F
Baghdadli, A
AF Rattaz, Cecile
Dubois, Amandine
Michelon, Cecile
Viellard, Marine
Poinso, Franois
Baghdadli, Amaria
TI How do children with autism spectrum disorders express pain? A
comparison with developmentally delayed and typically developing
children
SO PAIN
LA English
DT Article
DE Age-related; Autism spectrum disorder (ASD); Behavioral reactions;
Facial activity; Pain
ID SELF-INJURIOUS-BEHAVIOR; OF-THE-LITERATURE; COGNITIVE IMPAIRMENTS;
SCHIZOPHRENIA; PERCEPTION; CHECKLIST
AB There is a lack of knowledge about pain reactions in children with autism spectrum disorders (ASD), who have often been considered as insensitive to pain. The objective of this study was to describe the facial, behavioral and physiological reactions of children with ASD during venipuncture and to compare them to the reactions of children with an intellectual disability and nonimpaired control children. We also examined the relation between developmental age and pain reactions. The sample included 35 children with ASD, 32 children with an intellectual disability, and 36 nonimpaired children. The children were video-taped during venipuncture and their heart rate was recorded. Facial reactions were assessed using the Child Facial Coding System (CFCS) and behavioral reactions were scored using the Noncommunicating Children's Pain Checklist (NCCPC). A linear mixed-effects model showed that children's reactions increased between baseline and venipuncture and decreased between the end of venipuncture and the recovery period. There was no significant difference between groups regarding the amount of facial, behavioral and physiological reactions. However, behavioral reactions seemed to remain high in children with ASD after the end of the venipuncture, in contrast with children in the 2 other groups. Moreover, we observed a significant decrease in pain expression with age in nonimpaired children, but no such effect was found regarding children with ASD. The data reveal that children with ASD displayed a significant pain reaction in this situation and tend to recover more slowly after the painful experience. Improvement in pain assessment and management in this population is necessary. (C) 2013 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved.
C1 [Rattaz, Cecile; Michelon, Cecile; Baghdadli, Amaria] CHRU Montpellier, Ctr Ressources Autisme, Dept Univ Pedopsychiatrie, F-34295 Montpellier 5, France.
[Rattaz, Cecile; Baghdadli, Amaria] Univ Montpellier, Lab Epsylon, EA 4556, F-34059 Montpellier, France.
[Dubois, Amandine] Univ Brest Occidentale, EPS EA 4686, Brest, France.
[Viellard, Marine; Poinso, Franois] Hop St Marguerite, Ctr Ressources Autisme, Serv Pedopsychiatr, Marseille, France.
RP Rattaz, C (reprint author), CHRU Montpellier, Ctr Ressources Autisme Languedoc Roussillon, Equipe Colombiere, Dept Univ Pedopsychiat, 291 Ave Doyen Giraud, F-34295 Montpellier 5, France.
EM c-rattaz@chu-montpellier.fr
FU National Clinical Research Program (PHRC) [NCT 01043822]; Orange
Foundation
FX This research was supported by Grant NCT 01043822 from the National
Clinical Research Program (PHRC) and by a grant from the Orange
Foundation. The authors sincerely thank the children and their families
who participated in this study. We are also grateful to the pediatric
and care units from Montpellier (Pr Sarda, Pr Rivier, Dr Rodiere, Dr
Jeziorski) and Marseille (Pr Philip), who participated in this study.
The authors would also like to thank Myriam Soussana and Veena
Murdymootoo, who assisted with collection of the data.
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NR 29
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3959
J9 PAIN
JI Pain
PD OCT
PY 2013
VL 154
IS 10
BP 2007
EP 2013
DI 10.1016/j.pain.2013.06.011
PG 7
WC Anesthesiology; Clinical Neurology; Neurosciences
SC Anesthesiology; Neurosciences & Neurology
GA 219AK
UT WOS:000324475500018
PM 24040973
ER
PT J
AU Deconinck, N
Soncarrieu, M
Dan, B
AF Deconinck, Nicolas
Soncarrieu, Marie
Dan, Bernard
TI Toward Better Recognition of Early Predictors for Autism Spectrum
Disorders
SO PEDIATRIC NEUROLOGY
LA English
DT Review
DE autism; early signs; sibling prospective studies; NICU
ID PERVASIVE DEVELOPMENTAL DISORDERS; HIGH-FUNCTIONING AUTISM; HEAD
CIRCUMFERENCE; BIOLOGICAL MOTION; HOME VIDEOTAPES; INFANT SIBLINGS;
BIRTH-WEIGHT; 1ST YEAR; AGE; DIAGNOSIS
AB BACKGROUND: Identification and diagnosis of autism spectrum disorders is essentially based on behavioral presentation and developmental history. The current average age at diagnosis is older than 3 years. METHODS: Over the past 15 years, there has been increasing documentation of the early signs of autism spectrum disorders through both individual retrospective parental reports and screening studies. Recent longitudinal studies have focused on early medical and behavioral features of children regarded at risk, namely younger siblings of children with autism spectrum disorders or children who required neonatal intensive care, with a later diagnosis of autism spectrum disorders. RESULTS: Potentially useful early neurological signs and developmental predictors for autism spectrum disorders could be identified, with a typical profile that evolved with age. CONCLUSIONS: Assessment of early social attention and communication skills with adapted scales in children before the age of 18 months in very large community-based settings may lead to high positive predictive values.
C1 [Deconinck, Nicolas; Dan, Bernard] Univ Libre Brussels, Hop Univ Enfants Reine Fabiola, Dept Neurol, Brussels, Belgium.
[Soncarrieu, Marie] Univ Libre Brussels, Hop Univ Enfants Reine Fabiola, Dept Child Psychiat, Brussels, Belgium.
RP Deconinck, N (reprint author), HUDERF, Dept Neurol, Av JJ Crocq 15, B-1020 Brussels, Belgium.
EM nicolas.deconinck@huderf.be
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NR 69
TC 2
Z9 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0887-8994
J9 PEDIATR NEUROL
JI Pediatr. Neurol.
PD OCT
PY 2013
VL 49
IS 4
BP 225
EP 231
DI 10.1016/j.pediatrneurol.2013.05.012
PG 7
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 226MT
UT WOS:000325041200003
PM 23932805
ER
PT J
AU Ghaziuddin, M
Al-Owain, M
AF Ghaziuddin, Mohammad
Al-Owain, Mohammed
TI Autism Spectrum Disorders and Inborn Errors of Metabolism: An Update
SO PEDIATRIC NEUROLOGY
LA English
DT Review
DE autism; metabolic disorders; autism spectrum disorders; inborn errors of
metabolism
ID PYRIDOXINE-DEPENDENT EPILEPSY; CREATINE DEFICIENCY SYNDROMES; CEREBRAL
FOLATE-DEFICIENCY; PYRIMIDINE METABOLISM; SANFILIPPO-SYNDROME;
MENTAL-RETARDATION; PROPIONIC-ACID; SAUDI-ARABIA; DISEASE; DIAGNOSIS
AB BACKGROUND: Autism spectrum disorder is characterized by social communicative deficits with restricted interests occurring in about 1% of the population. Although its exact cause is not known, several factors have been implicated in its etiology, including inborn errors of metabolism. Although relatively uncommon, these disorders frequently occur in countries with high rates of consanguinity and are often associated with behavioral problems, such as hyperactivity and aggression. The aim of this review is to examine the association of autism with these conditions. METHOD: A computer-assisted search was performed to identify the most common inborn errors of metabolism associated with autism. RESULTS: The following disorders were identified: phenylketonuria, glucose-6-phosphatase deficiency, propionic acidemia, adenosine deaminase deficiency, Smith-Lemli-Opitz syndrome and mitochondrial disorders, and the recently described branched chain ketoacid dehydrogenase kinase deficiency. CONCLUSION: The risk of autistic features is increased in children with inborn errors of metabolism, especially in the presence of cognitive and behavioral deficits. We propose that affected children should be screened for autism.
C1 Univ Michigan, Ann Arbor, MI 48109 USA.
King Faisal Specialist Hosp & Res Ctr, Riyadh 11211, Saudi Arabia.
RP Ghaziuddin, M (reprint author), Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
EM mghaziud@umich.edu
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NR 58
TC 2
Z9 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0887-8994
J9 PEDIATR NEUROL
JI Pediatr. Neurol.
PD OCT
PY 2013
VL 49
IS 4
BP 232
EP 236
DI 10.1016/j.pediatrneurol.2013.05.013
PG 5
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 226MT
UT WOS:000325041200004
PM 23921282
ER
PT J
AU Youssef, J
Singh, K
Huntington, N
Becker, R
Kothare, SV
AF Youssef, Julie
Singh, Kanwaljit
Huntington, Noelle
Becker, Ronald
Kothare, Sanjeev V.
TI Relationship of Serum Ferritin Levels to Sleep Fragmentation and
Periodic Limb Movements of Sleep on Polysomnography in Autism Spectrum
Disorders
SO PEDIATRIC NEUROLOGY
LA English
DT Article
DE autism; sleep; ferritin levels; iron deficiency
ID RESTLESS LEGS SYNDROME; CHILDREN
AB OBJECTIVE: Although children with autism spectrum disorders experience a range of sleep disturbances, exact mechanisms are not well-characterized. We investigated the association of serum-ferritin to sleep fragmentation and periodic limb movements of sleep using polysomnography in children with autism spectrum disorders. METHODS: We conducted a retrospective chart review of children with autism spectrum disorders followed from 1990 to 2010. Inclusion criteria were availability of polysomnography data and ferritin levels within 12 months of each other. The following variables on polysomnography characterized sleep fragmentation: increased arousal index, alpha intrusions, and reduced sleep efficiency. The data were compared with age- and gender-matched controls. RESULTS: Of 9791 children with autism spectrum disorders identified, 511 had a ferritin level, 377 had polysomnography data, and 53 had both ferritin and polysomnography data. As compared with the controls (86 ng/mL), the median ferritin level was 27 ng/mL in the study autism spectrum disorders population (53 patients) (P <0.01), 27 ng/mL in autism spectrum disorder subjects with periodic limb movements of sleep (25 patients) (P = 0.01), and 24 ng/mL in autism spectrum disorders subjects with sleep fragmentation (21 patients) (P = 0.02). Within the autism spectrum disorders population, median ferritin levels were significantly lower in patients with poor sleep efficiency (7 ng/mL) versus those with normal sleep efficiency (29 ng/mL) (P = 0.01). The prevalence of periodic limb movements of sleep was 47% in autism spectrum disorders compared with 8% in controls (P < 0.01). CONCLUSION: Children with autism spectrum disorders had significantly lower ferritin levels compared with controls. In addition, they experience a higher prevalence of sleep fragmentation, obstructive sleep apnea, and periodic limb movements of sleep than children with ASD and no sleep complaints. Our preliminary observations, which have not been described before, need to be validated in multicenter prospective studies.
C1 [Youssef, Julie; Huntington, Noelle; Becker, Ronald] Harvard Univ, Sch Med, Dept Neurol, Div Dev Med,Boston Childrens Hosp, Boston, MA 02115 USA.
[Singh, Kanwaljit] Harvard Univ, Sch Med, Lurie Ctr Autism, Massachusetts Gen Hosp Children, Boston, MA USA.
[Singh, Kanwaljit; Kothare, Sanjeev V.] Harvard Univ, Sch Med, Dept Neurol, Div Clin Neurophysiol,Childrens Hosp, Boston, MA 02115 USA.
RP Kothare, SV (reprint author), NYU, Comprehens Epilepsy Ctr, Ctr Med, 223 East 34th St, New York, NY 10016 USA.
EM sanjeev.kothare@nyumc.org
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NR 30
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0887-8994
J9 PEDIATR NEUROL
JI Pediatr. Neurol.
PD OCT
PY 2013
VL 49
IS 4
BP 274
EP 278
DI 10.1016/j.pediatrneurol.2013.06.012
PG 5
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 226MT
UT WOS:000325041200009
PM 24053984
ER
PT J
AU Gongidi, P
Johnson, C
Dinan, D
AF Gongidi, Preetam
Johnson, Craig
Dinan, David
TI Scurvy in an autistic child: MRI findings
SO PEDIATRIC RADIOLOGY
LA English
DT Article
DE Scurvy; Vitamin C deficiency; Autism; Food-avoidant behavior
AB Scurvy results from a deficiency of vitamin C and is rarely seen in the United States. We describe the MRI findings of a case of scurvy in an autistic child with food-avoidant behavior. Advanced imaging is rarely performed in clinically well-understood disease entities such as scurvy. Typical radiographic findings are well described leading to definitive diagnosis, although the findings can be missed or misinterpreted given the rarity of scurvy in daily practice. To our knowledge, MRI features of scurvy in children in the US have been described in only one case report. This case of scurvy in an autistic child with food-avoidant behavior emphasizes that classic nutritional deficiencies, despite their rarity, must be included in the differential diagnosis of at-risk populations.
C1 [Gongidi, Preetam] Rowan Univ, Cooper Univ Hosp, Cooper Med Sch, Dept Radiol, Camden, NJ 08103 USA.
[Johnson, Craig; Dinan, David] Nemours Childrens Hosp, Dept Med Imaging Radiol, Orlando, FL 32827 USA.
RP Gongidi, P (reprint author), Rowan Univ, Cooper Univ Hosp, Cooper Med Sch, Dept Radiol, 1 Cooper Plaza,B23, Camden, NJ 08103 USA.
EM gongidi-preetam@cooperhealth.edu
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NR 8
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0301-0449
J9 PEDIATR RADIOL
JI Pediatr. Radiol.
PD OCT
PY 2013
VL 43
IS 10
BP 1396
EP 1399
DI 10.1007/s00247-013-2688-z
PG 4
WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging
SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging
GA 221FQ
UT WOS:000324643600020
PM 23604286
ER
PT J
AU Broder-Fingert
AF Broder-Fingert
TI Racial and Ethnic Differences in Subspecialty Service Use by Children
With Autism (vol 132, pg 94, 2013)
SO PEDIATRICS
LA English
DT Correction
CR Broder-Fingert, 2013, PEDIATRICS, V132, P780, DOI 10.1542/peds.2013-2034
NR 1
TC 1
Z9 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD OCT
PY 2013
VL 132
IS 4
BP 780
EP 780
DI 10.1542/peds.2013-2034
PG 1
WC Pediatrics
SC Pediatrics
GA 227FI
UT WOS:000325095400060
ER
PT J
AU Adams, RC
Tapia, C
AF Adams, Richard C.
Tapia, Carl
CA COUNCIL CHILDREN DISABILITIES
TI Early Intervention, IDEA Part C Services, and the Medical Home:
Collaboration for Best Practice and Best Outcomes
SO PEDIATRICS
LA English
DT Article
DE Part C; IDEA; medical home; children with special health care needs;
CSHCN; collaboration; comanagement; coaching; learning in the natural
environment
ID HEALTH-CARE NEEDS; EARLY-CHILDHOOD-INTERVENTION; AUTISM SPECTRUM
DISORDERS; WEIGHT PREMATURE-INFANTS; DEVELOPMENTAL DELAY;
YOUNG-CHILDREN; BIRTH-WEIGHT; PRESCRIBING THERAPY; DEVELOPMENT PROGRAM;
FOOD INSECURITY
AB The medical home and the Individuals With Disabilities Education Act Part C Early Intervention Program share many common purposes for infants and children ages 0 to 3 years, not the least of which is a family-centered focus. Professionals in pediatric medical home practices see substantial numbers of infants and toddlers with developmental delays and/or complex chronic conditions. Economic, health, and family-focused data each underscore the critical role of timely referral for relationship-based, individualized, accessible early intervention services and the need for collaborative partnerships in care. The medical home process and Individuals With Disabilities Education Act Part C policy both support nurturing relationships and family-centered care; both offer clear value in terms of economic and health outcomes. Best practice models for early intervention services incorporate learning in the natural environment and coaching models. Proactive medical homes provide strategies for effective developmental surveillance, family-centered resources, and tools to support high-risk groups, and comanagement of infants with special health care needs, including the monitoring of services provided and outcomes achieved.
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NR 111
TC 5
Z9 5
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD OCT
PY 2013
VL 132
IS 4
BP E1073
EP E1088
DI 10.1542/peds.2013-2305
PG 16
WC Pediatrics
SC Pediatrics
GA 227FI
UT WOS:000325095400033
PM 24082001
ER
PT J
AU Graber, TE
Hebert-Seropian, S
Khoutorsky, A
David, A
Yewdell, JW
Lacaille, JC
Sossin, WS
AF Graber, Tyson E.
Hebert-Seropian, Sarah
Khoutorsky, Arkady
David, Alexandre
Yewdell, Jonathan W.
Lacaille, Jean-Claude
Sossin, Wayne S.
TI Reactivation of stalled polyribosomes in synaptic plasticity
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE RNA granule; mGluR-LTD; translation elongation; microtubule-associated
protein 1b
ID LONG-TERM DEPRESSION; MENTAL-RETARDATION PROTEIN; FRAGILE-X;
HIPPOCAMPAL-NEURONS; RNA GRANULES; TRANSLATION INITIATION; DEPENDENT
TRANSLATION; AUTISM; PATHOPHYSIOLOGY; TRANSLOCATION
AB Some forms of synaptic plasticity require rapid, local activation of protein synthesis. Although this is thought to reflect recruitment of mRNAs to free ribosomes, this would limit the speed and magnitude of translational activation. Here we provide compelling in situ evidence supporting an alternative model in which synaptic mRNAs are transported as stably paused polyribosomes. Remarkably, we show that metabotropic glutamate receptor activation allows the synthesis of proteins that lead to a functional long-term depression phenotype even when translation initiation has been greatly reduced. Thus, neurons evolved a unique mechanism to swiftly translate synaptic mRNAs into functional protein upon synaptic signaling using stalled polyribosomes to bypass the rate-limiting step of translation initiation. Because dysregulated plasticity is implicated in neurodevelopmental and psychiatric disorders such as fragile X syndrome, this work uncovers a unique translational target for therapies.
C1 [Graber, Tyson E.; Sossin, Wayne S.] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada.
[Hebert-Seropian, Sarah; Lacaille, Jean-Claude] Univ Montreal, Grp Rech Syst Nerveux Cent, Dept Neurosci, Montreal, PQ H3T 1J4, Canada.
[Khoutorsky, Arkady] McGill Univ, Dept Biochem, Montreal, PQ H3A 1A3, Canada.
[Khoutorsky, Arkady] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada.
[David, Alexandre; Yewdell, Jonathan W.] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA.
RP Sossin, WS (reprint author), McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada.
EM wayne.sossin@mcgill.ca
FU Montreal Neurological Institute; Fonds de recherche du Quebec-Sante;
Universite de Montreal; Canadian Institutes of Health Research
FX Pateamine A was a generous gift of Dr. Jerry Pelletier. The GFP-FMRP
expression plasmid was a kind gift of Dr. Keith Murai. T. E. G. is
supported by a Jeanne Timmins-Costello Fellowship from the Montreal
Neurological Institute and a Postdoctoral Fellowship from the Fonds de
recherche du Quebec-Sante. S.H.-S. is supported by a Graduate
Studentship from Universite de Montreal. This work was funded by the
Canadian Institutes of Health Research (J.-C.L. and W. S. S.) and Fonds
de recherche du Quebec-Sante (J.-C.L. and W. S. S.). J.-C.L. is the
recipient of the Canada Research Chair in Cellular and Molecular
Neurophysiology.
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NR 35
TC 21
Z9 21
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD OCT 1
PY 2013
VL 110
IS 40
BP 16205
EP 16210
DI 10.1073/pnas.1307747110
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 227II
UT WOS:000325105500081
PM 24043809
ER
PT J
AU Calcagnoli, F
de Boer, SF
Althaus, M
den Boer, JA
Koolhaas, JM
AF Calcagnoli, Federica
de Boer, Sietse F.
Althaus, Monika
den Boer, Johan A.
Koolhaas, Jaap M.
TI Antiaggressive activity of central oxytocin in male rats
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Oxytocin; Offensive aggression; Social exploration; Individual
variability
ID VOLES MICROTUS-OCHROGASTER; RECEPTOR GENE OXTR; HYPOTHALAMIC
PARAVENTRICULAR NUCLEUS; LATERAL SEPTAL VASOPRESSIN; FEMALE
SYRIAN-HAMSTERS; AGGRESSIVE-BEHAVIOR; CEREBROSPINAL-FLUID; SOCIAL
RECOGNITION; PRAIRIE VOLES; CENTRAL AMYGDALA
AB A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents.
Our primary goal was to examine the putative serenic effect of oxytocin in a feral strain (wild type Groningen, WTG) of rats that generally show a much broader variation and higher levels of intermale aggression than commonly used laboratory strains of rats.
Resident animals were intracerebroventricularly (icv) administered with different doses of synthetic oxytocin and oxytocin receptor antagonist, alone and in combination, in order to manipulate brain oxytocin functioning and to assess their behavioral response to an intruder.
Our data clearly demonstrate that acute icv administered oxytocin produces dose-dependent and receptor-selective changes in social behavior, reducing aggression and potentiating social exploration. These antiaggressive effects are stronger in the more offensive rats. On the other hand, administration of an oxytocin receptor antagonist tends to increase (nonsignificantly) aggression only in low-medium aggressive animals.
These results suggest that transiently enhancing brain oxytocin function has potent antiaggressive effects, whereas its attenuation tends to enhance aggressiveness. In addition, a possible inverse relationship between trait aggression and endogenous oxytocinergic signaling is revealed. Overall, this study emphasizes the importance of brain oxytocinergic signaling for regulating intermale offensive aggression. This study supports the suggestion that oxytocin receptor agonists could clinically be useful for curbing heightened aggression seen in a range of neuropsychiatric disorders like antisocial personality disorder, autism, and addiction.
C1 [Calcagnoli, Federica; de Boer, Sietse F.; Koolhaas, Jaap M.] Univ Groningen, Dept Behav Physiol, NL-9700 CC Groningen, Netherlands.
[Althaus, Monika] Univ Groningen, Univ Med Ctr Groningen, NL-9713 GZ Groningen, Netherlands.
[Calcagnoli, Federica; den Boer, Johan A.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9700 RB Groningen, Netherlands.
RP Calcagnoli, F (reprint author), Univ Groningen, Dept Behav Physiol, POB 30001, NL-9700 CC Groningen, Netherlands.
EM f.calcagnoli@rug.nl
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NR 115
TC 15
Z9 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD OCT
PY 2013
VL 229
IS 4
BP 639
EP 651
DI 10.1007/s00213-013-3124-7
PG 13
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 224HB
UT WOS:000324872600008
PM 23624810
ER
PT J
AU Mehta, NK
Lee, H
Ylitalo, KR
AF Mehta, Neil. K.
Lee, Hedwig
Ylitalo, Kelly R.
TI Child health in the United States: Recent trends in racial/ethnic
disparities
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Race; Ethnicity; Inequality; Disparities; Child health; Asthma; Autism;
Trends; United States
ID SOCIOECONOMIC-STATUS; US CHILDREN; HYGIENE HYPOTHESIS; ETHNIC
DISPARITIES; INCREASED PREVALENCE; RACIAL DISPARITIES; ASTHMA
PREVALENCE; AFRICAN-AMERICAN; RACE; CARE
AB In the United States, race and ethnicity are considered key social determinants of health because of their enduring association with social and economic opportunities and resources. An important policy and research concern is whether the U.S. is making progress toward reducing racial/ethnic inequalities in health. While race/ethnic disparities in infant and adult outcomes are well documented, less is known about patterns and trends by race/ethnicity among children. Our objective was to determine the patterns of and progress toward reducing racial/ethnic disparities in child health. Using nationally representative data from 1998 to 2009, we assessed 17 indicators of child health, including overall health status, disability, measures of specific illnesses, and indicators of the social and economic consequences of illnesses. We examined disparities across five race/ethnic groups (non-Hispanic white, non-Hispanic black, Hispanic, non-Hispanic Asian, and non-Hispanic other). We found important racial/ethnic disparities across nearly all of the indicators of health we examined, adjusting for socioeconomic status, nativity, and access to health care. Importantly, we found little evidence that racial/ethnic disparities in child health have changed over time. In fact, for certain illnesses such as asthma, black white disparities grew significantly larger over time. In general, black children had the highest reported prevalence across the health indicators and Asian children had the lowest reported prevalence. Hispanic children tended to be more similar to whites compared to the other race/ethnic groups, but there was considerable variability in their relative standing. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Mehta, Neil. K.] Emory Univ, Atlanta, GA 30322 USA.
[Lee, Hedwig] Univ Washington, Seattle, WA 98195 USA.
[Ylitalo, Kelly R.] Univ Michigan, Ann Arbor, MI 48109 USA.
RP Mehta, NK (reprint author), Emory Univ, 1518 Clifton Rd,CNR 7035, Atlanta, GA 30322 USA.
EM nkmehta@emory.edu
FU Robert Wood Johnson Foundation; National Institute on Minority Health
and Health Disparities
FX The authors would like to thank the Robert Wood Johnson Foundation
Health and Society Scholars program for its financial support. Neil K.
Mehta was additionally supported by the National Institute on Minority
Health and Health Disparities' Loan Repayment Program. An earlier
version of this paper was presented at the Population Association of
America 2012 Annual Conference (San Francisco, CA). We thank Enrico A.
Marcelli and three anonymous reviewers for their helpful comments. The
content in this article is solely the responsibility of the authors and
does not necessarily represent the official views of any agency.
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NR 76
TC 9
Z9 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD OCT
PY 2013
VL 95
SI SI
BP 6
EP 15
DI 10.1016/j.socscimed.2012.09.011
PG 10
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 221OR
UT WOS:000324668700002
PM 23034508
ER
PT J
AU Mazumdar, S
Winter, A
Liu, KY
Bearman, P
AF Mazumdar, Soumya
Winter, Alix
Liu, Ka-Yuet
Bearman, Peter
TI Spatial clusters of autism births and diagnoses point to contextual
drivers of increased prevalence
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Autism; Spatial clustering; California; Neighborhood resources; GIS;
Geography; Mobility
ID PHYSICIAN DENSITY; SOCIOECONOMIC-STATUS; SPECTRUM DISORDERS;
RISK-FACTORS; POPULATION; CALIFORNIA; DISEASE; RATES; CANCER;
SURVEILLANCE
AB Autism prevalence has risen dramatically over the past two decades in California. Although often suggested to have been crucial to the rise of autism, environmental and social contextual drivers of diagnosis have not been extensively examined. Identifying the spatial patterning of autism cases at birth and at diagnosis can help clarify which contextual drivers are affecting autism's rising prevalence. Children with autism not co-morbid with mental retardation served by the California Department of Developmental Services during the period 1992-2005 were matched to California's Birth Master Files. We search for spatial clusters of autism at time of birth and at time of diagnosis using a spatial scan approach that controls for key individual-level risk factors. We then test whether indicators of neighborhood-level diagnostic resources are associated with the diagnostic clusters and assess the extent of clustering by autism symptom severity through a multivariate scan. Finally, we test whether children who move into neighborhoods with higher levels of resources are more likely to receive an autism diagnosis relative to those who do not move with regard to resources. Significant birth and diagnostic clusters of autism are observed independent of key individual-level risk factors. While the clusters overlap, there is a strong positive association between the diagnostic clusters and neighborhood-level diagnostic resources. In addition, children with autism who are higher functioning are more likely to be diagnosed within a cluster than children with autism who are lower functioning. Most importantly, children who move into a neighborhood with more diagnostic resources than their previous residence are more likely to subsequently receive an autism diagnosis than children whose neighborhood resources do not change. We identify birth and diagnostic clusters of autism in California that are independent of individual-level autism risk factors. Our findings implicate a causal relationship between neighborhood-level diagnostic resources and spatial patterns of autism incidence but do not rule out the possibility that environmental toxicants have also contributed to autism risk. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Mazumdar, Soumya] Australian Natl Univ, Australian Primary Hlth Care Res Inst, Canberra, ACT 0200, Australia.
[Winter, Alix] Harvard Univ, Cambridge, MA 02138 USA.
[Liu, Ka-Yuet] Univ Calif Los Angeles, Los Angeles, CA USA.
[Bearman, Peter] Columbia Univ, New York, NY 10027 USA.
RP Mazumdar, S (reprint author), Australian Natl Univ, Australian Primary Hlth Care Res Inst, Level 1,Ian Potter House,Cnr Marcus Clarke & Gord, Canberra, ACT 0200, Australia.
EM soumya.com@gmail.com
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NR 53
TC 4
Z9 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD OCT
PY 2013
VL 95
SI SI
BP 87
EP 96
DI 10.1016/j.socscimed.2012.11.032
PG 10
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 221OR
UT WOS:000324668700011
PM 23267775
ER
PT J
AU Ramisch, JL
Timm, TM
Hock, RM
Topor, JA
AF Ramisch, Julie L.
Timm, Tina M.
Hock, Robert M.
Topor, Jessica A.
TI Experiences Delivering a Marital Intervention for Couples With Children
With Autism Spectrum Disorder
SO AMERICAN JOURNAL OF FAMILY THERAPY
LA English
DT Article
ID CHRONICALLY ILL CHILDREN; IN-HOME THERAPY; FAMILIES
AB Previous researchers have indicated that parents of children with autism spectrum disorder (ASD) are vulnerable to relationship stress, lower marital satisfaction, and potential relationship dissolution. We describe the experiences of three couples who participated in a 10-week, in-home couples therapy intervention using Emotionally Focused Therapy (EFT). Each couple and their progress through the intervention are described using therapist and supervisor reflections, and qualitative evaluation interviews with the participants after termination. Based on the experiences of the couples, we conclude that couples would benefit from an in-home couples therapy intervention aimed to strengthen their relationships.
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[Timm, Tina M.; Topor, Jessica A.] Michigan State Univ, E Lansing, MI 48824 USA.
[Hock, Robert M.] Univ S Carolina, Columbia, SC 29208 USA.
RP Ramisch, JL (reprint author), No Illinois Univ, Wirtz Hall 118, De Kalb, IL 60115 USA.
EM julie.ramisch@gmail.com
CR Brobst JB, 2009, FOCUS AUTISM DEV DIS, V24, P38, DOI 10.1177/1088357608323699
Centers for Disease Control and Prevention, 2012, MMWR-MORBID MORTAL W, V61, pSS
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NR 18
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0192-6187
J9 AM J FAM THER
JI Am. J. Fam. Ther.
PD OCT 1
PY 2013
VL 41
IS 5
BP 376
EP 388
DI 10.1080/01926187.2012.713816
PG 13
WC Psychology, Clinical; Family Studies
SC Psychology; Family Studies
GA 212RX
UT WOS:000324001600003
ER
PT J
AU Smith, AL
Freeman, SM
Voll, RJ
Young, LJ
Goodman, MM
AF Smith, Aaron L.
Freeman, Sara M.
Voll, Ronald J.
Young, Larry J.
Goodman, Mark M.
TI Investigation of an F-18 oxytocin receptor selective ligand via PET
imaging
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Oxytocin; Oxytocin receptor; Receptor imaging; Fluorine-18; PET imaging;
Cerebral ventricles; Choroid plexus; Alpha-1 adrenergic receptor;
Adrenergic receptor
ID POLYGAMOUS VOLES; SOCIAL-BEHAVIOR; BINDING-SITES; HUMAN BRAIN;
VASOPRESSIN; AUTISM; MECHANISMS; EXPRESSION; DISORDERS; SYSTEM
AB The compound 1-(1-(2-(2-(2-fluoroethoxy)-4-(piperidin-4-yloxy)phenyl)acetyl) piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one (1) was synthesized and positively evaluated in vitro for high potency and selectivity with human oxytocin receptors. The positron emitting analogue, [F-18]1, was synthesized and investigated in vivo via PET imaging using rat and cynomolgus monkey models. PET imaging studies in female Sprague-Dawley rats suggested [F-18]1 reached the brain and accumulated in various regions of the brain, but washed out too rapidly for adequate quantification and localization. In vivo PET imaging studies in a male cynomolgus monkey suggested [F-18]1 had limited brain penetration while specific uptake of radioactivity significantly accumulated within the vasculature of the cerebral ventricles in areas representative of the choroid plexus. (C) 2013 Published by Elsevier Ltd.
C1 [Smith, Aaron L.; Voll, Ronald J.; Goodman, Mark M.] Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30329 USA.
[Smith, Aaron L.; Freeman, Sara M.; Young, Larry J.] Yerkes Natl Primate Res Ctr, Dept Psychiat & Behav Sci, Ctr Translat Social Neurosci, Atlanta, GA 30322 USA.
RP Young, LJ (reprint author), Yerkes Natl Primate Res Ctr, Dept Psychiat & Behav Sci, Ctr Translat Social Neurosci, Atlanta, GA 30322 USA.
EM lyoun03@emory.edu; mgoodma@emory.edu
FU National Institute of Mental Health [5 R21 MH090776]; NIH [MH064692];
National Center for Research Resources [P51RR165, P51OD11132]
FX We thank Larry Williams, Mel Camp and Eugene Malveaux for their
contributions to the rodent studies. We thank the Yerkes National
Primate Imaging Suite staff for their aid in performing non-human
primate scans. We thank the NIMH PDSP directed by Bryan L. Roth M.D,
Ph.D at the University of North Carolina at Chapel Hill and Project
Officer Jamie Driscol at NIMH, Bethesda MD, USA for their contributions
of the human cell line studies. This research was funded by the National
Institute of Mental Health through grant 5 R21 MH090776. We also
acknowledge NIH MH064692 (L.J.Y.) and the National Center for Research
Resources P51RR165 (currently P51OD11132) to YNPRC.
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NR 28
TC 4
Z9 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
EI 1464-3405
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD OCT 1
PY 2013
VL 23
IS 19
BP 5415
EP 5420
DI 10.1016/j.bmcl.2013.07.045
PG 6
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA 216RX
UT WOS:000324302800031
PM 23978650
ER
PT J
AU Nikopoulos, CK
Nikopoulou-Smyrni, P
Konstantopoulos, K
AF Nikopoulos, Christos K.
Nikopoulou-Smyrni, Panagiota
Konstantopoulos, Kostas
TI Effects of video modelling on emerging speech in an adult with traumatic
brain injury: Preliminary findings
SO BRAIN INJURY
LA English
DT Article
DE Speech; traumatic brain injury; video modelling
ID AUTISM SPECTRUM DISORDERS; QUALITY-OF-LIFE; LANGUAGE THERAPY; COGNITIVE
REHABILITATION; MEMORY REHABILITATION; PATIENT PARTICIPATION;
LEARNING-THEORY; HEAD-INJURY; MODERATE; INDIVIDUALS
AB Primary objective: Research has shown that traumatic brain injury (TBI) can affect a person's ability to perform previously learned skills. Dysexecutive syndrome and inattention, for example, alongside a number of other cognitive and behavioural impairments such as memory loss and lack of motivation, significantly affect day-to-day functioning following TBI. This study examined the efficacy of video modelling in emerging speech in an adult male with TBI caused by an assault.
Research design: In an effort to identify functional relations between this novice intervention and the target behaviour, experimental control was achieved by using within-system research methodology, overcoming difficulties of forming groups for such an highly non-homogeneous population.
Methods and procedures: Across a number of conditions, the participant watched a videotape in which another adult modelled a selection of 19 spoken words. When this modelled behaviour was performed in vivo, then generalization across 76 other words in the absence of a videotape took place.
Main outcomes and results: It was revealed that video modelling can promote the performance of previously learned behaviours related to speech, but more significantly it can facilitate the generalization of this verbal behaviour across untrained words.
Conclusions: Video modelling could well be added within the rehabilitation programmes for this population.
C1 [Nikopoulos, Christos K.; Nikopoulou-Smyrni, Panagiota] Brunel Univ, Sch Hlth Sci & Social Care, Uxbridge UB8 3PH, Middx, England.
[Konstantopoulos, Kostas] European Univ Cyprus, Sch Humanities & Social Sci, Nicosia, Cyprus.
RP Nikopoulos, CK (reprint author), Brunel Univ, Sch Hlth Sci & Social Care, Mary Seacole Bldg, Uxbridge UB8 3PH, Middx, England.
EM christos.nikopoulos@brunel.ac.uk
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NR 73
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0269-9052
J9 BRAIN INJURY
JI Brain Inj.
PD OCT
PY 2013
VL 27
IS 11
BP 1256
EP 1262
DI 10.3109/02699052.2013.809550
PG 7
WC Neurosciences; Rehabilitation
SC Neurosciences & Neurology; Rehabilitation
GA 217YQ
UT WOS:000324399800004
PM 23909660
ER
PT J
AU Hattier, MA
Matson, JL
Macmillan, K
Williams, L
AF Hattier, Megan A.
Matson, Johnny L.
Macmillan, Katherine
Williams, Lindsey
TI Stereotyped behaviours in children with autism spectrum disorders and
atypical development as measured by the BPI-01
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE Autism spectrum disorders; BPI-01; stereotyped behaviours
ID SELF-INJURIOUS-BEHAVIOR; CHALLENGING BEHAVIORS; PROBLEMS-INVENTORY;
INTELLECTUAL DISABILITIES; ABERRANT BEHAVIOR; YOUNG-CHILDREN; REPETITIVE
BEHAVIOR; DIAGNOSTIC FIDELITY; INFANT SCREEN; PDD-NOS
AB Objective: As repetitive behaviours in children with autism spectrum disorders (ASDs) can significantly interfere with one's daily functioning, continued research on these behaviours is needed.
Methods: This study examined the occurrence of repetitive motor movements in toddlers (17-37 months) with ASD and atypical development and the relationship between stereotypies and sensory impairment.
Results: Children with ASD (n = 13) exhibited significantly more repetitive behaviours than the non-ASD group (n = 12). Greater percentages of endorsement were evident for the ASD group on nearly all items of the Behaviour Problems Inventory-01 (BPI-01) Stereotypy subscale. More repetitive behaviours tended to co-occur with other stereotypies for the ASD group. A moderate correlation was found between stereotypy severity and sensory deficits.
Conclusion: These findings suggest that stereotyped behaviours can be identified at very young ages, negatively affect the behavioural presentation of those with ASDs and should be considered when developing treatment plans.
C1 [Hattier, Megan A.; Matson, Johnny L.; Macmillan, Katherine; Williams, Lindsey] Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
RP Matson, JL (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM johnmatson@aol.com
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NR 60
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD OCT
PY 2013
VL 16
IS 5
BP 291
EP 300
DI 10.3109/17518423.2012.727107
PG 10
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA 217YV
UT WOS:000324400400001
PM 24020875
ER
PT J
AU Ninci, J
Lang, R
Davenport, K
Lee, A
Garner, J
Moore, M
Boutot, A
Rispoli, M
Lancioni, G
AF Ninci, Jennifer
Lang, Russell
Davenport, Katy
Lee, Allyson
Garner, Jennifer
Moore, Melissa
Boutot, Amanda
Rispoli, Mandy
Lancioni, Giulio
TI An analysis of the generalization and maintenance of eye contact taught
during play
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE Autism spectrum disorders; pervasive developmental disability; eye
contact; intervention; differential reinforcement
ID JOINT ATTENTION; NONVERBAL-COMMUNICATION; SOCIAL INTERACTIONS; UNIQUE
MORPHOLOGY; CHILDREN; AUTISM; BEHAVIOR
AB Purpose: Differential reinforcement and most-to-least prompting were implemented within the context of developmentally appropriate play activities in an effort to improve the eye contact between a 4-year-old boy with pervasive developmental disorder-not otherwise specified (PDD-NOS) and his three therapists.
Methods: A multiple baseline design across therapists was used to examine the eye contact of a 4-year-old boy with PDD-NOS. Maintenance data were collected at 1, 2 and 3 months post intervention.
Results: The intervention was effective and improvements in eye contact were maintained for at least 3 months post intervention. However, eye contact did not readily generalize across communication partners.
Conclusions: Results suggest that eye contact may not generalize to communication partners who are not directly involved in intervention. Results are discussed in terms of implications for practitioners and directions for future research.
C1 [Ninci, Jennifer; Lang, Russell; Davenport, Katy; Lee, Allyson; Garner, Jennifer; Moore, Melissa; Boutot, Amanda] SW Texas State Univ, Clin Autism Res Evaluat & Support, San Marcos, TX 78666 USA.
[Rispoli, Mandy] Texas A&M Univ, Dept Educ Psychol, College Stn, TX 77843 USA.
[Lancioni, Giulio] Univ Bari, Dept Psychol, Bari, Italy.
RP Ninci, J (reprint author), SW Texas State Univ, Clin Autism Res Evaluat & Support, Coll Educ Bldg,601 Univ Dr, San Marcos, TX 78666 USA.
EM jninci@neo.tamu.edu
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NR 27
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD OCT
PY 2013
VL 16
IS 5
BP 301
EP 307
DI 10.3109/17518423.2012.730557
PG 7
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA 217YV
UT WOS:000324400400002
PM 24020876
ER
PT J
AU Castro, S
Ferreira, T
Dababnah, S
Pinto, AI
AF Castro, Susana
Ferreira, Tiago
Dababnah, Sarah
Pinto, Ana Isabel
TI Linking autism measures with the ICF-CY: Functionality beyond the
borders of diagnosis and interrater agreement issues
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE Childhood; disability; ICF-CY; autism; functioning
ID INDIVIDUALIZED EDUCATION-PROGRAMS; INTERNATIONAL CLASSIFICATION;
PSYCHOMETRIC EVALUATION; SPECTRUM DISORDERS; CHILDREN; PARTICIPATION;
DISABILITY; HEALTH; YOUTH; REHABILITATION
AB Purpose: This study aims to: (1) link measurements used in the diagnosis of children with autism spectrum disorders (ASDs) with the International Classification of Functioning, Disability and Health - Children and Youth Version (ICF-CY) and (2) analyse issues relating with interrater agreement within this process.
Method: Three instruments for ASD diagnosis were linked with the ICF-CY using deductive content analysis.
Results: Correspondences between items' content and ICF-CY dimensions were identified for all ICF-CY components, except for environmental factors. Interrater agreement varied with the content of the units analyzed.
Conclusion: The linkage between the ICF-CY and the analyzed measures provides a way to document assessment-intervention outcomes using a common language, as well as to integrate diagnostic and functional data. Diagnostic measurements provide functional information beyond the diagnostic criteria defined for autism. A functional perspective is added to diagnostic outcomes, thus better informing educational and rehabilitation practices for children with ASD.
C1 [Castro, Susana; Ferreira, Tiago; Pinto, Ana Isabel] Univ Porto, Fac Psychol & Educ Sci, P-4100 Oporto, Portugal.
[Dababnah, Sarah] Univ N Carolina, Sch Social Work, Chapel Hill, NC USA.
RP Castro, S (reprint author), Univ Porto, Fac Psychol & Educ Sci, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
EM susanacastro161@gmail.com
FU Fundacao para a Ciencia e Tecnologia; Sam and Betsy Reeves Doctoral
Fellowship Fund at the University of North Carolina School of Social
Work
FX Susana Castro acknowledges the support of the Fundacao para a Ciencia e
Tecnologia for funding this study. Sarah Dababnah acknowledges the
support of the Sam and Betsy Reeves Doctoral Fellowship Fund at the
University of North Carolina School of Social Work.
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NR 42
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD OCT
PY 2013
VL 16
IS 5
BP 321
EP 331
DI 10.3109/17518423.2012.733438
PG 11
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA 217YV
UT WOS:000324400400005
PM 23869843
ER
PT J
AU Huskens, B
Verschuur, R
Gillesen, J
Didden, R
Barakova, E
AF Huskens, Bibi
Verschuur, Rianne
Gillesen, Jan
Didden, Robert
Barakova, Emilia
TI Promoting question-asking in school-aged children with autism spectrum
disorders: Effectiveness of a robot intervention compared to a
human-trainer intervention
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE Autism spectrum disorders; robot intervention; high-functioning children
ID INTENSIVE BEHAVIORAL INTERVENTIONS; SOCIALLY ASSISTIVE ROBOTICS;
OF-THE-ART; PIVOTAL RESPONSE; YOUNG-CHILDREN; COMMUNICATION;
INDIVIDUALS; IMITATION; SCALES
AB Objective: The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis (ABA)-based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder (ASD).
Methods: Data were collected in a combined crossover multiple baseline design across participants. Six children were randomly assigned to two experimental groups.
Results: Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up. The high number of self-initiated questions during follow-up indicates that both groups maintained this skill.
Conclusions: The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD. No conclusion with regard to the differential effectiveness of both interventions could be drawn. Implications of the results and directions for future research are discussed.
C1 [Huskens, Bibi; Verschuur, Rianne] Dr Leo Kannerhuis, Res & Dev, NL-6865 ZH Doorwerth, Netherlands.
[Gillesen, Jan; Barakova, Emilia] Eindhoven Univ Technol, Fac Ind Design, NL-5600 MB Eindhoven, Netherlands.
[Didden, Robert] Radboud Univ Nijmegen, Inst Behav Sci, NL-6525 ED Nijmegen, Netherlands.
RP Huskens, B (reprint author), Dr Leo Kannerhuis, Res & Dev, POB 62,Houtsnipl 1, NL-6865 ZH Doorwerth, Netherlands.
EM b.huskens@leokannerhuis.nl
RI Huskens, Bibi/G-1685-2014
FU Dutch Ministry of Economic Affairs, Agriculture and Innovation, The
Hague
FX The authors gratefully acknowledge the support of the
Innovation-Oriented Research Program "Integral Product Creation and
Realization (IOP IPCR)'' of the Dutch Ministry of Economic Affairs,
Agriculture and Innovation, The Hague. The authors thank the children,
their parents, and the staff of the day treatment group and the clinical
treatment facility of the Dr Leo Kannerhuis for their participation. We
also would like to thank Margreet Weide and Anke van der Linden for
their assistance during preparation and data collection. Finally, we
would like to thank Iris Soute for her assistance with the robot in the
sessions and Tino Lourens, TiViPE, for his assistance in programming the
robot.
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NR 47
TC 1
Z9 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD OCT
PY 2013
VL 16
IS 5
BP 345
EP 356
DI 10.3109/17518423.2012.739212
PG 12
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA 217YV
UT WOS:000324400400008
PM 23586852
ER
PT J
AU Chouinard, PA
Noulty, WA
Sperandio, I
Landry, O
AF Chouinard, Philippe A.
Noulty, William A.
Sperandio, Irene
Landry, Oriane
TI Global processing during the Muller-Lyer illusion is distinctively
affected by the degree of autistic traits in the typical population
SO EXPERIMENTAL BRAIN RESEARCH
LA English
DT Article
DE Muller-Lyer illusion; Ebbinghaus illusion; Ponzo illusion; Autism
Spectrum Quotient (AQ) questionnaire; Autism spectrum disorders; Vision
ID HIGH-FUNCTIONING AUTISM; WEAK CENTRAL COHERENCE; SPECTRUM QUOTIENT AQ;
ASPERGER-SYNDROME; VISUAL ILLUSIONS; COGNITIVE-STYLE; HUMAN V1;
PERCEPTION; SIZE; ATTENTION
AB Earlier work examining susceptibility to visual illusions in autism has reported discrepant findings. Some of this research suggests that global processing is affected in autism while some of this research suggests otherwise. The discrepancies may relate to compliance issues and differences in population samples in terms of symptom severity, cognitive ability, and co-morbid disorders. Equally important, most of this work tended to treat global processing as if it were a singular construct, invoking similar cognitive operations across different visual illusions. We argue that this is not a fair assumption to make given the extensive research that has classified visual illusions on the basis of their cognitive demands. With this in mind, and to overcome the many caveats associated with examining a heterogeneous disorder such as autism directly, we examined how susceptibility to various illusions relates differently to people's scores on the Autism Spectrum Quotient (AQ) questionnaire. We found that susceptibility to the Muller-Lyer but not to the Ebbinghaus and Ponzo illusions decreased as a function of AQ and that the relationship between AQ and susceptibility to the Muller-Lyer illusion was different from those between AQ and susceptibility to the Ebbinghaus and Ponzo illusions. Our findings confirm that the cognitive operations underlying global processing in the Muller-Lyer illusion are different from the other illusions and, more importantly, reveal that they might be affected in autism. Future brain mapping studies could provide additional insight into the neural underpinnings of how global processing might and might not be affected in autism.
C1 [Chouinard, Philippe A.; Sperandio, Irene] Univ Western Ontario, Dept Psychol Brain & Mind Inst, London, ON N6A 5B8, Canada.
[Noulty, William A.; Landry, Oriane] Dalhousie Univ, Dept Psychol, Halifax, NS B3H 4R2, Canada.
[Sperandio, Irene] Univ E Anglia, Sch Psychol, Norwich NR4 7TJ, Norfolk, England.
[Landry, Oriane] McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON L8S 4K1, Canada.
RP Chouinard, PA (reprint author), Univ Western Ontario, Dept Psychol Brain & Mind Inst, 1151 Richmond St, London, ON N6A 5B8, Canada.
EM pchouin@uwo.ca
FU Ontario Mental Health Foundation; Ontario Ministry of Research and
Innovation
FX This work was supported by postdoctoral fellowship awards from the
Ontario Mental Health Foundation to P.A.C and from the Ontario Ministry
of Research and Innovation to I.S.
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NR 54
TC 6
Z9 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4819
J9 EXP BRAIN RES
JI Exp. Brain Res.
PD OCT
PY 2013
VL 230
IS 2
BP 219
EP 231
DI 10.1007/s00221-013-3646-6
PG 13
WC Neurosciences
SC Neurosciences & Neurology
GA 217DD
UT WOS:000324336000007
PM 23864047
ER
PT J
AU Wang, CC
Lin, HC
Chan, YH
Gean, PW
Yang, YK
Chen, PS
AF Wang, Chao-Chuan
Lin, Hui-Ching
Chan, Yun-Han
Gean, Po-Wu
Yang, Yen Kung
Chen, Po See
TI 5-HT1A-receptor agonist modified amygdala activity and
amygdala-associated social behavior in a valproate-induced rat autism
model
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Amygdala; autistic spectrum disorders; serotonin; SPECT; valproate
ID ACUTE-TRYPTOPHAN-DEPLETION; SEROTONIN TRANSPORTER; BASOLATERAL AMYGDALA;
SYNAPTIC PLASTICITY; SPECTRUM DISORDERS; BRAIN; ACID; CHILDREN;
ADOLESCENTS; HIPPOCAMPUS
AB Accumulating evidence suggests that dysfunction of the amygdala is related to abnormal fear processing, anxiety, and social behaviors noted in autistic spectrum disorders (ASDs). In addition, studies have shown that disrupted brain serotonin homeostasis is linked to ASD. With a valproate (VPA)-induced rat ASD model, we investigated the possible role of amygdala serotonin homeostasis in autistic phenotypes and further explored the underlying mechanism. We first discovered that the distribution of tryptophan hydroxylase immunoreactivity in the caudal raphe system was modulated on postnatal day (PD) 28 of the VPA-exposed offspring. Then, we found a significantly higher serotonin transporter availability in the amygdala of the VPA-exposed offspring on PD 56 by using single photon emission computed tomography and computed tomography co-registration following injection of I-123-labeled 2-((2-(dimethylamino) methyl) phenyl) thio)-5-iodophenylamine(I-123[ADAM]). Furthermore, treatment with 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a 5-HT1A receptor agonist, increased social interaction and improved fear memory extinction in the VPA-exposed offspring. 8-OH-DPAT treatment also reversed the characteristics of miniature excitatory post-synaptic currents as well as paired pulse facilitation observed in lateral amygdala slices. These results provided further evidence to support the role of the amygdala in characteristic behavioral changes in the rat ASD model. The serotonergic projections that modulate the amygdala function might play a certain role in the development and treatment of behavioral symptoms exhibited in individuals with ASD.
C1 [Wang, Chao-Chuan] Kaohsiung Med Univ, Coll Med, Dept Anat, Kaohsiung, Taiwan.
[Lin, Hui-Ching] Natl Yang Ming Univ, Sch Med, Dept & Inst Physiol, Taipei 112, Taiwan.
[Lin, Hui-Ching] Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, Taiwan.
[Chan, Yun-Han; Gean, Po-Wu] Natl Cheng Kung Univ, Dept Pharmacol, Coll Med, Tainan 70403, Taiwan.
[Yang, Yen Kung; Chen, Po See] Natl Cheng Kung Univ, Dept Psychiat, Coll Med, Natl Cheng Kung Univ Hosp, Tainan 70403, Taiwan.
[Yang, Yen Kung; Chen, Po See] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 70403, Taiwan.
RP Chen, PS (reprint author), Natl Cheng Kung Univ, Dept Psychiat, Coll Med, 138 Sheng Li Rd, Tainan 70403, Taiwan.
EM chenps@mail.ncku.edu.tw
FU National Science Council of Taiwan [NSC 96-2314-B-006-056-MY3, NSC
99-2628-B-006-013-MY3, NSC 100-2320-B-010-033-MY2]; National Cheng Kung
University Hospital, Ministry of Education of Taiwan; Aim for the Top
University Plan from the National Cheng Kung University; Aim for the Top
University Plan from National Yang-Ming University; Kaohsiung Medical
University [KMU-M-110014]
FX The authors thank Mr Chien Ting Lin, Mr Chao Yuan Chang and all of the
research participants. This study was supported by grants from the
National Science Council of Taiwan (NSC 96-2314-B-006-056-MY3, NSC
99-2628-B-006-013-MY3, NSC 100-2320-B-010-033-MY2), National Cheng Kung
University Hospital, Ministry of Education of Taiwan, Aim for the Top
University Plan from the National Cheng Kung University and National
Yang-Ming University and Kaohsiung Medical University (KMU-M-110014).
The funding institutions of this study had no further role in the study
design, collection, analysis, and interpretation of data, the writing of
this paper, or the decision to submit it for publication. The authors
thank OxBioSci for English editing.
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NR 70
TC 5
Z9 5
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1461-1457
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD OCT
PY 2013
VL 16
IS 9
BP 2027
EP 2039
DI 10.1017/S1461145713000473
PG 13
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 213AT
UT WOS:000324026000010
PM 23823694
ER
PT J
AU Marmel, F
Linley, D
Carlyon, RP
Gockel, HE
Hopkins, K
Plack, CJ
AF Marmel, F.
Linley, D.
Carlyon, R. P.
Gockel, H. E.
Hopkins, K.
Plack, C. J.
TI Subcortical Neural Synchrony and Absolute Thresholds Predict Frequency
Discrimination Independently
SO JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
LA English
DT Article
DE FFR; sensorineural hearing loss; pitch perception; neural phase locking;
age
ID AUDITORY BRAIN-STEM; AUTISM SPECTRUM DISORDERS; HARMONIC COMPLEX TONES;
COCHLEAR HEARING-LOSS; PITCH DISCRIMINATION; DIFFERENCE LIMENS; SPEECH
RECEPTION; NERVE FIBERS; REPRESENTATION; PERCEPTION
AB The neural mechanisms of pitch coding have been debated for more than a century. The two main mechanisms are coding based on the profiles of neural firing rates across auditory nerve fibers with different characteristic frequencies (place-rate coding), and coding based on the phase-locked temporal pattern of neural firing (temporal coding). Phase locking precision can be partly assessed by recording the frequency-following response (FFR), a scalp-recorded electrophysiological response that reflects synchronous activity in subcortical neurons. Although features of the FFR have been widely used as indices of pitch coding acuity, only a handful of studies have directly investigated the relation between the FFR and behavioral pitch judgments. Furthermore, the contribution of degraded neural synchrony (as indexed by the FFR) to the pitch perception impairments of older listeners and those with hearing loss is not well known. Here, the relation between the FFR and pure-tone frequency discrimination was investigated in listeners with a wide range of ages and absolute thresholds, to assess the respective contributions of subcortical neural synchrony and other age-related and hearing loss-related mechanisms to frequency discrimination performance. FFR measures of neural synchrony and absolute thresholds independently contributed to frequency discrimination performance. Age alone, i.e., once the effect of subcortical neural synchrony measures or absolute thresholds had been partialed out, did not contribute to frequency discrimination. Overall, the results suggest that frequency discrimination of pure tones may depend both on phase locking precision and on separate mechanisms affected in hearing loss.
C1 [Marmel, F.; Linley, D.; Hopkins, K.; Plack, C. J.] Univ Manchester, Sch Psychol Sci, Manchester M13 9PL, Lancs, England.
[Carlyon, R. P.; Gockel, H. E.] MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England.
RP Marmel, F (reprint author), Univ Manchester, Sch Psychol Sci, Manchester M13 9PL, Lancs, England.
EM frederic.marmel@gmail.com
FU MRC [G0900591]
FX This work was supported by MRC grant G0900591
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NR 55
TC 7
Z9 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1525-3961
J9 JARO-J ASSOC RES OTO
JI JARO
PD OCT
PY 2013
VL 14
IS 5
BP 757
EP 766
DI 10.1007/s10162-013-0402-3
PG 10
WC Neurosciences; Otorhinolaryngology
SC Neurosciences & Neurology; Otorhinolaryngology
GA 214EK
UT WOS:000324113600011
PM 23760984
ER
PT J
AU Abu-Dahab, SMN
Skidmore, ER
Holm, MB
Rogers, JC
Minshew, NJ
AF Abu-Dahab, Sana M. N.
Skidmore, Elizabeth R.
Holm, Margo B.
Rogers, Joan C.
Minshew, Nancy J.
TI Motor and Tactile-Perceptual Skill Differences Between Individuals with
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SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Motor skills; Coordination; Strength; Tactile-perceptual skills;
Stereognosis
ID ASPERGER SYNDROME; GRIP STRENGTH; CHILDREN; CONNECTIVITY; PERFORMANCE;
MOVEMENT; DISORDER; DEFICITS; ASSOCIATION; IMPAIRMENT
AB We examined motor and tactile-perceptual skills in individuals with high-functioning autism (IHFA) and matched typically developing individuals (TDI) ages 5-21 years. Grip strength, motor speed and coordination were impaired in IHFA compared to matched TDI, and the differences between groups varied with age. Although tactile-perceptual skills of IHFA were impaired compared to TDI on several measures, impairments were significant only for stereognosis. Motor and tactile-perceptual skills should be assessed in children with IHFA and intervention should begin early because these skills are essential to school performance. Impairments in coordination and stereognosis suggest a broad though selective under-development of the circuitry for higher order abilities regardless of domain that is important in the search for the underlying disturbances in neurological development.
C1 [Abu-Dahab, Sana M. N.] Univ Jordan, Occupat Therapy Dept, Fac Rehabil Sci, Amman, Jordan.
[Skidmore, Elizabeth R.; Holm, Margo B.; Rogers, Joan C.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Occupat Therapy, Pittsburgh, PA USA.
[Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat & Neurol, Pittsburgh, PA USA.
RP Abu-Dahab, SMN (reprint author), Univ Jordan, Occupat Therapy Dept, Fac Rehabil Sci, Amman, Jordan.
EM s.abudahab@ju.edu.jo
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NR 44
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2241
EP 2248
DI 10.1007/s10803-011-1439-y
PG 8
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500001
PM 22318760
ER
PT J
AU Falck-Ytter, T
von Hofsten, C
Gillberg, C
Fernell, E
AF Falck-Ytter, Terje
von Hofsten, Claes
Gillberg, Christopher
Fernell, Elisabeth
TI Visualization and Analysis of Eye Movement Data from Children with
Typical and Atypical Development
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Learning; Eye tracking; Scientific visualization; Bottom-up; Knowledge
generation; Autism spectrum disorder; Diagnosis; Attention; Social
dominance; Social hierarchies; Conflict; Goals
ID AUTISM SPECTRUM DISORDER; SOCIAL SCENES; GAZE; PATTERNS; ATTENTION;
BEHAVIOR
AB Looking at other children's interactions provides rich learning opportunities for a small child. How children with autism look at other children is largely unknown. Using eye tracking, we studied gaze performance in children with autism and neurotypical comparison children while they were watching videos of semi-naturalistic social interactions between young children. Using a novel, bottom-up approach we identified event-related measures that distinguished between groups with high accuracy. The observed effects remained in a subset of the total sample matched on IQ, and were replicated across several different stimuli. The described method facilitates the detection of meaningful patterns in complex eye tracking data. Also, the approach significantly improves visualization, which will help investigators understand, illustrate, and generate new hypotheses.
C1 [Falck-Ytter, Terje] Astrid Lindgren Childrens Hosp Q2 07, Karolinska Inst KIND, Dept Womens & Childrens Hlth, Ctr Neurodev Disorders, S-17176 Stockholm, Sweden.
[Falck-Ytter, Terje; von Hofsten, Claes] Uppsala Univ, Dept Psychol, S-75142 Uppsala, Sweden.
[Falck-Ytter, Terje; Gillberg, Christopher; Fernell, Elisabeth] Gothenburg Univ, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
[Fernell, Elisabeth] Autism Ctr Young Children Habilitat & Hlth, Stockholm, Sweden.
RP Falck-Ytter, T (reprint author), Astrid Lindgren Childrens Hosp Q2 07, Karolinska Inst KIND, Dept Womens & Childrens Hlth, Ctr Neurodev Disorders, S-17176 Stockholm, Sweden.
EM terje.falck-ytter@ki.se
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NR 30
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2249
EP 2258
DI 10.1007/s10803-013-1776-0
PG 10
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500002
PM 23381485
ER
PT J
AU Gonzalez, C
Martin, JM
Minshew, NJ
Behrmann, M
AF Gonzalez, Cleotilde
Martin, Jolie M.
Minshew, Nancy J.
Behrmann, Marlene
TI Practice Makes Improvement: How Adults with Autism Out-Perform Others in
a Naturalistic Visual Search Task
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Visual search; Luggage screening
ID ENHANCED DISCRIMINATION; SPECTRUM DISORDERS; COGNITIVE-STYLE;
EYE-MOVEMENTS; SUPERIOR; CONNECTIVITY; PERCEPTION; VIGILANCE; STIMULI
AB People with autism spectrum disorder (ASD) often exhibit superior performance in visual search compared to others. However, most studies demonstrating this advantage have employed simple, uncluttered images with fully visible targets. We compare the performance of high-functioning adults with ASD and matched controls on a naturalistic luggage screening task. Although the two groups were equally accurate in detecting targets, the ASD adults improve in their correct elimination of target-absent bags faster than controls. This feature of their behavior is extremely important for many real-world monitoring tasks that require sustained attention for long time periods. Further analyses suggest that this improvement is attributable neither to the motor speed nor to the level of intelligence of the adults with ASD. These findings may have possible implications for employment opportunities of adult individuals with ASD.
C1 [Gonzalez, Cleotilde] Carnegie Mellon Univ, Dynam Decis Making Lab, Pittsburgh, PA 15213 USA.
[Martin, Jolie M.] Univ Minnesota, Sch Journalism & Mass Commun, Minneapolis, MN 55455 USA.
[Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA.
[Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA.
[Behrmann, Marlene] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
RP Gonzalez, C (reprint author), Carnegie Mellon Univ, Dynam Decis Making Lab, Pittsburgh, PA 15213 USA.
EM coty@cmu.edu
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NR 39
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2259
EP 2268
DI 10.1007/s10803-013-1772-4
PG 10
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500003
PM 23381483
ER
PT J
AU Scarpa, A
Reyes, NM
Patriquin, MA
Lorenzi, J
Hassenfeldt, TA
Desai, VJ
Kerkering, KW
AF Scarpa, Angela
Reyes, Nuri M.
Patriquin, Michelle A.
Lorenzi, Jill
Hassenfeldt, Tyler A.
Desai, Varsha J.
Kerkering, Kathryn W.
TI The Modified Checklist for Autism in Toddlers: Reliability in a Diverse
Rural American Sample
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE M-CHAT; Autism screening; Reliability; Diverse populations
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; SCREENING TOOL;
MENTAL-HEALTH; PRIMARY-CARE; CHILDREN; DIAGNOSIS; AGE; BEHAVIORS;
IDENTIFICATION
AB This study investigated the psychometric properties of the modified checklist for autism in toddlers (M-CHAT) in a diverse rural American low-socioeconomic status (SES) sample. Four hundred and forty-seven English (n = 335) and Spanish (n = 112) speaking caregivers completed the M-CHAT during their toddler's 18- or 24-month well visit in a Southwest Virginia pediatric clinic. The M-CHAT did not show acceptable internal consistency in groups with low maternal education or minority status. Caregivers reporting low maternal education and minority status were more likely to endorse items suggestive of autism. These results indicate that the M-CHAT may require modifications to be more internally consistent and accurate across ethnic and educational groups in rural areas with low levels of SES. Recommendations to increase the utility of the M-CHAT are discussed.
C1 [Scarpa, Angela; Reyes, Nuri M.; Patriquin, Michelle A.; Lorenzi, Jill; Hassenfeldt, Tyler A.] Virginia Tech, Dept Psychol, Blacksburg, VA 24061 USA.
[Desai, Varsha J.] Caril Clin, Dept Pediat, Roanoke, VA 24016 USA.
[Kerkering, Kathryn W.] Caril Clin, Dept Pediat, Pediat Neurodev Clin, Roanoke, VA 24016 USA.
RP Scarpa, A (reprint author), Virginia Tech, Dept Psychol, 109 Williams Hall, Blacksburg, VA 24061 USA.
EM ascarpa@vt.edu; reynados@vt.edu; mpatriq@vt.edu; lorenzi@vt.edu;
thassen@vt.edu; vjdesai@carilionclinic.org;
kwkerkering@carilionclinic.org
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
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NR 43
TC 3
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2269
EP 2279
DI 10.1007/s10803-013-1779-x
PG 11
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500004
PM 23386118
ER
PT J
AU de Bildt, A
Oosterling, IJ
van Lang, NDJ
Kuijper, S
Dekker, V
Sytema, S
Oerlemans, AM
van Steijn, DJ
Visser, JC
Rommelse, NN
Minderaa, RB
van Engeland, H
van der Gaag, RJ
Buitelaar, JK
de Jonge, MV
AF de Bildt, Annelies
Oosterling, Iris J.
van Lang, Natasja D. J.
Kuijper, Sanne
Dekker, Vera
Sytema, Sjoerd
Oerlemans, Anoek M.
van Steijn, Daphne J.
Visser, Janne C.
Rommelse, Nanda N.
Minderaa, Ruud B.
van Engeland, Herman
van der Gaag, Rutger-Jan
Buitelaar, Jan K.
de Jonge, Maretha V.
TI How to Use the ADI-R for Classifying Autism Spectrum Disorders?
Psychometric Properties of Criteria from the Literature in 1,204 Dutch
Children
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ADI-R; Autism; ASD; Diagnosis; Classification; Validity
ID DIAGNOSTIC-OBSERVATION-SCHEDULE; ADOS REVISED ALGORITHM;
MENTAL-RETARDATION; ADOLESCENTS
AB The algorithm of the Autism Diagnostic Interview-Revised provides criteria for autism versus non-autism according to DSM-IV. Criteria for the broader autism spectrum disorders are needed. This study investigated the validity of seven sets of criteria from the literature, in 1,204 Dutch children (aged 3-18 years) with and without mental retardation. The original criteria (Rutter et al. in ADI-R Autism Diagnostic Interview Revised. Manual. Western Psychological Services, Los Angeles, 2003) well discriminated ASD from non-ASD in MR. All other criteria (IMGSAC in Am Soc Hum Genet 69:570-581 2001; Sung et al. in Am J Hum Genet 76: 68-81, 2005; Risi et al. in J Am Acad Child Adolesc Psychiatry 45: 1094-1103, 2006) were sensitive at the cost of specificity, bearing the risk of overinclusiveness. In the group without MR, clinicians should decide whether sensitivity or specificity is aimed for, to choose the appropriate criteria. Including the Autism Diagnostic Observation Schedule revised algorithms in the classification, the specificity increases, at the cost of sensitivity. This study adds to a more valid judgment on which criteria to use for specific objectives.
C1 [de Bildt, Annelies; Kuijper, Sanne; Minderaa, Ruud B.] Univ Groningen, Univ Med Ctr Groningen, Dept Child & Adolescent Psychiat, NL-9713 AV Groningen, Netherlands.
[de Bildt, Annelies; Kuijper, Sanne; Dekker, Vera; Minderaa, Ruud B.] Accare Groningen, Groningen, Netherlands.
[de Bildt, Annelies] UCKJP Groningen, Accare, NL-9700 AR Groningen, Netherlands.
[Oosterling, Iris J.; Oerlemans, Anoek M.; van Steijn, Daphne J.; Visser, Janne C.; Rommelse, Nanda N.; van der Gaag, Rutger-Jan; Buitelaar, Jan K.] Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands.
[van Lang, Natasja D. J.] Leiden Univ Med Ctr, Dept Child & Adolescent Psychiat, Curium, Leiden, Netherlands.
[Kuijper, Sanne] Univ Groningen, Ctr Language & Cognit, Groningen, Netherlands.
[Sytema, Sjoerd] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
[Oerlemans, Anoek M.; Rommelse, Nanda N.; van der Gaag, Rutger-Jan] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.
[Rommelse, Nanda N.; Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NCEBP, NL-6525 ED Nijmegen, Netherlands.
[van Engeland, Herman; de Jonge, Maretha V.] Univ Med Ctr Utrecht, Dept Child & Adolescent Psychiat, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
RP de Bildt, A (reprint author), UCKJP Groningen, Accare, POB 660, NL-9700 AR Groningen, Netherlands.
EM annelies.de.bildt@home.nl
RI Rommelse, Nanda/D-4872-2009; Gaag, R.J./H-8030-2014
OI Rommelse, Nanda/0000-0002-1711-0359;
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Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
NR 35
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2280
EP 2294
DI 10.1007/s10803-013-1783-1
PG 15
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500005
PM 23397166
ER
PT J
AU Raz, R
Lerner-Geva, L
Leon, O
Chodick, G
Gabis, LV
AF Raz, Raanan
Lerner-Geva, Liat
Leon, Odelia
Chodick, Gabriel
Gabis, Lidia V.
TI A Survey of Out-of-Pocket Expenditures for Children with Autism Spectrum
Disorder in Israel
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Pervasive developmental disorders; Autism spectrum disorders; Health
services; Out-of-pocket costs
ID HEALTH-CARE EXPENDITURES; UNITED-STATES; MEDICAID; SERVICE; ACCESS
AB We describe a survey of children with ASD aged 4-10 years. The main dependent variables were out-of-pocket expenditures for health services and hours of therapy. Multivariable logistic regression models were used in order to find independent predictors for service utilization. Parents of 178 of the children (87 %) agreed to participate. The average annual out-of-pocket cost was $8,288, with a median of $4,473 and a range of $0-89,754. Higher severity of ASD and a parent with an academic degree were associated with higher expenditure. Having at least one older sibling, siblings without developmental disorders, regular education setting, lower parent education and low income were associated with lower expenditure.
C1 [Raz, Raanan; Lerner-Geva, Liat; Chodick, Gabriel] Tel Aviv Univ, Sch Publ Hlth, IL-69978 Tel Aviv, Israel.
[Raz, Raanan; Chodick, Gabriel] Maccabi Healthcare Serv, Tel Aviv, Israel.
[Raz, Raanan] Harvard Univ, Sch Publ Hlth, Landmark Ctr, Boston, MA 02215 USA.
[Lerner-Geva, Liat] Gertner Inst, Women & Children Hlth Res Unit, Tel Hashomer, Israel.
[Leon, Odelia; Gabis, Lidia V.] Edmond & Lily Safra Childrens Hosp, Chaim Sheba Med Ctr, Weinberg Child Dev Ctr, Tel Hashomer, Israel.
[Gabis, Lidia V.] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
RP Raz, R (reprint author), Harvard Univ, Sch Publ Hlth, Landmark Ctr, 401 Pk Dr, Boston, MA 02215 USA.
EM rraz@hsph.harvard.edu
CR AAP, 2004, PEDIATRICS, V113, P1545
Croen LA, 2006, PEDIATRICS, V118, pE1203, DOI 10.1542/peds.2006-0127
Jarbrink K, 2003, J AUTISM DEV DISORD, V33, P395, DOI 10.1023/A:1025058711465
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Leslie DL, 2007, ARCH PEDIAT ADOL MED, V161, P350, DOI 10.1001/archpedi.161.4.350
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Wang L, 2010, J AM ACAD CHILD PSY, V49, P1165, DOI 10.1016/j.jaac.2010.08.003
NR 12
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2295
EP 2302
DI 10.1007/s10803-013-1782-2
PG 8
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500006
PM 23381487
ER
PT J
AU Stagg, SD
Davis, R
Heaton, P
AF Stagg, Steven D.
Davis, Robert
Heaton, Pamela
TI Associations Between Language Development and Skin Conductance Responses
to Faces and Eye Gaze in Children with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Language delay; Galvanic skin response; Language onset; Autism spectrum
disorder; Faces; Eye-gaze
ID HIGH-FUNCTIONING AUTISM; JOINT ATTENTION; DIAGNOSTIC INTERVIEW;
AUTONOMIC RESPONSES; PRESCHOOL-CHILDREN; ASPERGER-SYNDROME;
INFANTILE-AUTISM; AVERTED GAZE; TODDLERS; STIMULI
AB Attention to social stimuli is associated with language development, and arousal is associated with the increased viewing of stimuli. We investigated whether skin conductance responses (SCRs) are associated with language development in autism spectrum disorder (ASD): a population that shows abnormalities in both attention to others and language development. A sample of 32 children with ASD (7-15 year; M = 9 year) was divided into two groups, based on language onset histories. A typically developing comparison group consisted of 18 age and IQ matched children. SCRs were taken as the participants viewed faces. SCRs differentiated the ASD group based on language onset and were associated with abnormal attention to gaze in infancy and subsequent language development.
C1 [Stagg, Steven D.] Anglia Ruskin Univ, Cambridge, England.
[Davis, Robert; Heaton, Pamela] Univ London, London, England.
RP Stagg, SD (reprint author), Anglia Ruskin Univ, Cambridge, England.
EM steven.stagg@anglia.ac.uk
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WHO, 1992, ICD 10 WHO
NR 63
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2303
EP 2311
DI 10.1007/s10803-013-1780-4
PG 9
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500007
PM 23400348
ER
PT J
AU Bhatara, A
Babikian, T
Laugeson, E
Tachdjian, R
Sininger, YS
AF Bhatara, Anjali
Babikian, Talin
Laugeson, Elizabeth
Tachdjian, Raffi
Sininger, Yvonne S.
TI Impaired Timing and Frequency Discrimination in High-functioning Autism
Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Auditory perception; Psychophysics; Hyper-sensitivity; Asperger
syndrome; High-functioning autism
ID DEVELOPMENTAL LANGUAGE DISORDER; TEMPORAL PROCESSING DEFICIT;
AUDITORY-EVOKED-POTENTIALS; EVENT-RELATED POTENTIALS; BRAIN-STEM
RESPONSES; ASPERGER-SYNDROME; YOUNG-CHILDREN; GAP DETECTION;
HEARING-LOSS; PITCH DISCRIMINATION
AB Individuals with autism spectrum disorders (ASD) frequently demonstrate preserved or enhanced frequency perception but impaired timing perception. The present study investigated the processing of spectral and temporal information in 12 adolescents with ASD and 15 age-matched controls. Participants completed two psychoacoustic tasks: one determined frequency difference limens, and the other determined gap detection thresholds. Results showed impaired frequency discrimination at the highest standard frequency in the ASD group but no overall difference between groups. However, when groups were defined by auditory hyper-sensitivity, a group difference arose. For the gap detection task, the ASD group demonstrated elevated thresholds. This supports previous research demonstrating a deficit in ASD in temporal perception and suggests a connection between hyper-sensitivity and frequency discrimination abilities.
C1 [Bhatara, Anjali; Sininger, Yvonne S.] Univ Calif Los Angeles, Dept Head & Neck Surg, David Geffen Sch Med, Ctr Hlth Sci 62 132, Los Angeles, CA 90095 USA.
[Bhatara, Anjali] CNRS, Lab Psychol Percept, UMR 8158, F-75006 Paris, France.
[Babikian, Talin; Laugeson, Elizabeth] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USA.
[Laugeson, Elizabeth] Help Grp UCLA Autism Res Alliance, Sherman Oaks, CA 91401 USA.
[Tachdjian, Raffi] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
[Tachdjian, Raffi] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA.
RP Bhatara, A (reprint author), Univ Paris 05, Sorbonne Paris Cite, Paris, France.
EM bhatara@gmail.com
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NR 158
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2312
EP 2328
DI 10.1007/s10803-013-1778-y
PG 17
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500008
PM 23386117
ER
PT J
AU Koldewyn, K
Jiang, YV
Weigelt, S
Kanwisher, N
AF Koldewyn, Kami
Jiang, Yuhong V.
Weigelt, Sarah
Kanwisher, Nancy
TI Global/Local Processing in Autism: Not a Disability, but a
Disinclination
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Global/local processing; Global attention;
Cognitive development
ID HIGH-FUNCTIONING AUTISM; DEFICIT HYPERACTIVITY DISORDER; SPECTRUM
DISORDER; CONTRAST SENSITIVITY; SELECTIVE ATTENTION; ASPERGERS-DISORDER;
WEAK COHERENCE; VISUAL-SEARCH; PERCEPTION; ADOLESCENTS
AB It is widely suggested that ASD is characterized by atypical local/global processing, but the published findings are contradictory. In an effort to resolve this question, we tested a large group of children on both a free-choice task and an instructed task using hierarchical local-global stimuli. We find that although children with autism showed a reduced preference to report global properties of a stimulus when given a choice, their ability to process global properties when instructed to do so is unimpaired. These findings support prior claims that people with ASD show a disinclination, not a disability, in global processing, and highlight the broader question of whether other characteristics of autism may also reflect disinclinations rather than disabilities.
C1 [Koldewyn, Kami; Weigelt, Sarah; Kanwisher, Nancy] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Koldewyn, Kami; Weigelt, Sarah; Kanwisher, Nancy] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA.
[Jiang, Yuhong V.] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA.
RP Koldewyn, K (reprint author), MIT, Dept Brain & Cognit Sci, Bldg 46 Room 4141 Kanwisher Lab, Cambridge, MA 02139 USA.
EM kamik@mit.edu
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NR 41
TC 12
Z9 12
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2329
EP 2340
DI 10.1007/s10803-013-1777-z
PG 12
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500009
PM 23378063
ER
PT J
AU Hallett, V
Lecavalier, L
Sukhodolsky, DG
Cipriano, N
Aman, MG
McCracken, JT
McDougle, CJ
Tierney, E
King, BH
Hollander, E
Sikich, L
Bregman, J
Anagnostou, E
Donnelly, C
Katsovich, L
Dukes, K
Vitiello, B
Gadow, K
Scahill, L
AF Hallett, Victoria
Lecavalier, Luc
Sukhodolsky, Denis G.
Cipriano, Noreen
Aman, Michael G.
McCracken, James T.
McDougle, Christopher J.
Tierney, Elaine
King, Bryan H.
Hollander, Eric
Sikich, Linmarie
Bregman, Joel
Anagnostou, Evdokia
Donnelly, Craig
Katsovich, Lily
Dukes, Kimberly
Vitiello, Benedetto
Gadow, Kenneth
Scahill, Lawrence
TI Exploring the Manifestations of Anxiety in Children with Autism Spectrum
Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Anxiety; Measurement; Clinical Trials
ID PERVASIVE DEVELOPMENTAL DISORDERS; ABERRANT BEHAVIOR CHECKLIST;
OBSESSIVE-COMPULSIVE SCALE; YOUNG-PEOPLE; SYMPTOMS; VALIDITY;
RELIABILITY; RISPERIDONE; ADOLESCENTS; COMMUNITY
AB This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety was associated with functional language, IQ above 70 and higher scores on several other behavioral measures. Four underlying factors emerged: Generalized Anxiety, Separation Anxiety, Social Anxiety and Over-arousal. Our findings extend our understanding of anxiety across IQ in ASD and provide guidance for improving anxiety outcome measurement.
C1 [Hallett, Victoria; Sukhodolsky, Denis G.; Cipriano, Noreen; Katsovich, Lily; Scahill, Lawrence] Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
[Hallett, Victoria; Sukhodolsky, Denis G.; Cipriano, Noreen; Katsovich, Lily; Scahill, Lawrence] Yale Univ, Sch Nursing, New Haven, CT 06536 USA.
[Lecavalier, Luc; Aman, Michael G.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
[McCracken, James T.] Univ Calif Los Angeles, Sch Med, Div Child & Adolescent Psychiat, Semel Inst Neurosci, Los Angeles, CA USA.
[McDougle, Christopher J.] Massachusetts Gen Hosp Children, Lurie Ctr Autism, Boston, MA USA.
[McDougle, Christopher J.] Harvard Univ, Sch Med, Boston, MA USA.
[Tierney, Elaine] Kennedy Krieger Inst, Dept Psychiat, Baltimore, MD USA.
[King, Bryan H.] Univ Washington, Dept Psychiat, Seattle Childrens Hosp, Seattle, WA 98195 USA.
[Hollander, Eric] Albert Einstein Coll Med, Montefiore Med Ctr, New York, NY USA.
[Sikich, Linmarie] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
[Bregman, Joel] Ctr Autism, Philadelphia, PA USA.
[Anagnostou, Evdokia] Univ Toronto, Dept Pediat, Bloorview Res Inst, Toronto, ON, Canada.
[Donnelly, Craig] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Psychiat, Hanover, NH 03756 USA.
[Dukes, Kimberly] DM STAT Inc, Malden, MA USA.
[Dukes, Kimberly] Boston Univ, Dept Biostat, Boston, MA 02215 USA.
[Vitiello, Benedetto] NIMH, Bethesda, MD 20892 USA.
[Gadow, Kenneth] SUNY Stony Brook, Dept Psychiat & Behav Sci, Stony Brook, NY 11794 USA.
RP Scahill, L (reprint author), Emory Univ, Marcus Autism Ctr, 1920 Briarcliff Rd, Atlanta, GA 30329 USA.
EM lawrence.scahill@emory.edu
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NR 41
TC 7
Z9 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2341
EP 2352
DI 10.1007/s10803-013-1775-1
PG 12
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500010
PM 23400347
ER
PT J
AU Zalla, T
Labruyere, N
Georgieff, N
AF Zalla, Tiziana
Labruyere, Nelly
Georgieff, Nicolas
TI Perceiving Goals and Actions in Individuals with Autism Spectrum
Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Action parsing; Intention; Episodic memory; Biological motion
ID DYNAMIC HUMAN ACTION; MIRROR-NEURON SYSTEM; BIOLOGICAL MOTION; EVENT
PERCEPTION; ONGOING BEHAVIOR; INTERNAL-MODEL; VISUAL-MOTION; MOTOR
CONTROL; CHILDREN; INTENTIONS
AB In the present study, we investigated the ability to parse familiar sequences of action into meaningful events in young individuals with autism spectrum disorders (ASDs), as compared to young individuals with typical development (TD) and young individuals with moderate mental retardation or learning disabilities (MLDs). While viewing two videotaped movies, participants were requested to detect the boundary transitions between component events at both fine and coarse levels of the action hierarchical structure. Overall, reduced accuracy for event detection was found in participants with ASDs, relative to participants with TD, at both levels of action segmentation. The performance was, however, equally diminished in participants with ASDs and MLDs under the course-grained segmentation suggesting that difficulties to detect fine-grained events in ASDs cannot be explained by a general intellectual dysfunction. Reduced accuracy for event detection was related to diminished event recall, memory for event sequence and Theory of Mind abilities. We hypothesized that difficulties with event detection result from a deficit disrupting the on-line processing of kinematic features and physical changes of dynamic human actions. An impairment at the earlier stages of the event encoding process might contribute to deficits in episodic memory and social functioning in individuals with ASDs.
C1 [Zalla, Tiziana] Ecole Normale Super, Dept Etud Cognit, Inst Jean Nicod, CNRS, F-75005 Paris, France.
[Labruyere, Nelly] Inst Cognit Sci, Bron, France.
[Georgieff, Nicolas] Ctr Hosp Le Vinatier, ITTAC, Bron, France.
RP Zalla, T (reprint author), Ecole Normale Super, Dept Etud Cognit, Inst Jean Nicod, CNRS, 29 Rue Ulm, F-75005 Paris, France.
EM tiziana.zalla@ens.fr
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NR 81
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2353
EP 2365
DI 10.1007/s10803-013-1784-0
PG 13
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500011
PM 23420086
ER
PT J
AU Lemcke, S
Juul, S
Parner, ET
Lauritsen, MB
Thorsen, P
AF Lemcke, Sanne
Juul, Svend
Parner, Erik T.
Lauritsen, Marlene B.
Thorsen, Poul
TI Early Signs of Autism in Toddlers: A Follow-Up Study in the Danish
National Birth Cohort
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Intellectual disability; Early signs; Parents'
interview; Follow-up study; Birth cohort
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; CHILDREN;
PREVALENCE; ABNORMALITIES; RECOGNITION; REGRESSION; DIAGNOSIS; AGE;
IDENTIFICATION
AB To identify possible early signs of autism spectrum disorder (ASD) within the Danish National Birth Cohort, we studied prospectively collected interviews from 76,441 mothers about their children's development and behaviour at 6 and 18 months. In Danish national registries, 720 children with ASD and 231 children with intellectual disability (ID) were identified. At 6 months, associations between early signs and ASD or ID were found only in few areas. At 18 months social, language, and motor skills were delayed, and suspicion of vision and hearing problems were increased for both groups. Signs distinguishing ASD from ID were unclear, and the positive predictive values regarding ASD were below 10 % for individual predictors and aggregated risk scores.
C1 [Lemcke, Sanne; Lauritsen, Marlene B.] Aarhus Univ Hosp, Reg Ctr Child & Adolescent Psychiat, DK-8240 Risskov, Denmark.
[Juul, Svend] Univ Aarhus, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark.
[Parner, Erik T.] Univ Aarhus, Sch Publ Hlth, Dept Biostat, Aarhus, Denmark.
[Lauritsen, Marlene B.] Aalborg Univ Hosp, Res Unit Child & Adolescent Psychiat, Aalborg, Denmark.
[Thorsen, Poul] Lillebaelt Hosp, Dept Obstet & Gynaecol, Kolding, Denmark.
RP Lemcke, S (reprint author), Aarhus Univ Hosp, Reg Ctr Child & Adolescent Psychiat, Harald Selmers Vej 66, DK-8240 Risskov, Denmark.
EM sanne.lemcke@ps.rm.dk
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NR 41
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2366
EP 2375
DI 10.1007/s10803-013-1785-z
PG 10
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500012
PM 23404041
ER
PT J
AU Grossman, M
Peskin, J
San Juan, V
AF Grossman, Michael
Peskin, Joan
San Juan, Valerie
TI Thinking About a Reader's Mind: Fostering Communicative Clarity in the
Compositions of Youth with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Asperger syndrome; Referential communication; Writing; Theory of
mind; Intervention
ID HIGH-FUNCTIONING AUTISM; SCHOOL-AGE-CHILDREN; IMPROVING WRITTEN
COMMUNICATION; CAST CHILDHOOD ASPERGER; REFERENTIAL COMMUNICATION;
PSYCHOMETRIC EVALUATION; TEACHING THEORY; FALSE-BELIEF; LANGUAGE;
INDIVIDUALS
AB A critical component of effective communication is the ability to consider the knowledge state of one's audience, yet individuals with autism spectrum disorders (ASD) have difficulty representing the mental states of others. In the present study, youth with high-functioning ASD were trained to consider their reader's knowledge states in their compositions using a novel computer-based task. After two training trials, participants who received visual feedback from a confederate demonstrated significantly greater communicative clarity on the training measure compared to a control group. The improvements from training transferred to similar and very different tasks, and were maintained approximately 6 weeks post-intervention. These results provide support for the sustained efficacy of a rapid and motivating communication intervention for youth with high-functioning ASD.
C1 [Grossman, Michael] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada.
[Peskin, Joan; San Juan, Valerie] Univ Toronto, Dept Human Dev & Appl Psychol, OISE, Toronto, ON M5S 1V6, Canada.
RP Peskin, J (reprint author), Univ Toronto, Dept Human Dev & Appl Psychol, OISE, 252 Bloor St West, Toronto, ON M5S 1V6, Canada.
EM j.peskin@utoronto.ca
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NR 76
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2376
EP 2392
DI 10.1007/s10803-013-1786-y
PG 17
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500013
PM 23417283
ER
PT J
AU Travers, BG
Powell, PS
Mussey, JL
Klinger, LG
Crisler, ME
Klinger, MR
AF Travers, Brittany G.
Powell, Patrick S.
Mussey, Joanna L.
Klinger, Laura G.
Crisler, Megan E.
Klinger, Mark R.
TI Spatial and Identity Cues Differentially Affect Implicit Contextual
Cueing in Adolescents and Adults with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Implicit learning; Contextual cueing; Attention; Learning; Autism
ID MEMORY; INTACT; ATTENTION; DEFICITS; CHILDREN
AB The present studies examined implicit contextual cueing in adolescents and adults with Autism Spectrum Disorder (ASD). In Study 1, 16 individuals with ASD and 20 matched individuals with typical development completed a contextual cueing task using stimulus-identity cues. In Study 2, 12 individuals with ASD and 16 individuals with typical development completed a revised version of the contextual cueing task, using both stimulus-identity cues and global spatial-configuration cues. The results suggest that when only stimulus-identity cues were provided, individuals with ASD had difficulty with implicit contextual cueing (Study 1). However, when both stimulus-identity and spatial-configuration contextual cues were provided, individuals with ASD demonstrated successful contextual cueing (Study 2). Nuances in implicit learning and clinical implications are discussed.
C1 [Travers, Brittany G.; Powell, Patrick S.; Mussey, Joanna L.; Klinger, Laura G.; Crisler, Megan E.; Klinger, Mark R.] Univ Alabama, Dept Psychol, Tuscaloosa, AL 35487 USA.
[Travers, Brittany G.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
[Powell, Patrick S.] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA.
[Klinger, Laura G.] Univ N Carolina, Dept Psychiat, TEACCH Autism Program, Chapel Hill, NC USA.
[Klinger, Mark R.] Univ N Carolina, Dept Allied Hlth Sci, Chapel Hill, NC USA.
[Klinger, Mark R.] Univ N Carolina, Sch Med, Autism Program, Chapel Hill, NC USA.
RP Travers, BG (reprint author), Univ Wisconsin, Waisman Ctr, 1500 Highland Ave, Madison, WI 53705 USA.
EM btravers@wisc.edu
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NR 27
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2393
EP 2404
DI 10.1007/s10803-013-1787-x
PG 12
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500014
PM 23417264
ER
PT J
AU Schupp, CW
Simon, D
Corbett, BA
AF Schupp, Clayton W.
Simon, David
Corbett, Blythe A.
TI Cortisol Responsivity Differences in Children with Autism Spectrum
Disorders During Free and Cooperative Play
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Cortisol; Play; Social; Stress; Responder
ID HIGH-FUNCTIONING AUTISM; DEVELOPMENTAL-CHANGES; PSYCHOSOCIAL STRESS;
SALIVARY CORTISOL; CIRCADIAN-RHYTHMS; SQUIRREL-MONKEYS; ANXIETY;
COMMUNICATION; INTERVENTION; RECOGNITION
AB Children with autism spectrum disorder (ASD) demonstrate significant heterogeneity in their profiles of social interaction and stress responsivity. We evaluated behavior and stress response in 52 male children ages 8-12 in a naturalistic playground interaction paradigm involving a child with ASD, a typically developing peer, and a same-age confederate. Younger children in the ASD group engaged in 5.8 times more approach behavior and showed a lower cortisol response than their older peers. Those that verbally initiated with their peers also showed a higher cortisol response. Older children with ASD exhibited the highest stress responsivity, while younger children with ASD showed more willingness to approach others without apparent stress. Intervening early and often may contribute to improvements in social engagement in youth with ASD.
C1 [Schupp, Clayton W.] Canc Prevent Inst Calif, Fremont, CA USA.
[Simon, David; Corbett, Blythe A.] Vanderbilt Univ, Dept Psychiat, Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
RP Corbett, BA (reprint author), Vanderbilt Univ, Dept Psychiat, Vanderbilt Kennedy Ctr, PMB 40,230 Appleton Pl, Nashville, TN 37203 USA.
EM blythe.corbett@vanderbilt.edu
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NR 53
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2405
EP 2417
DI 10.1007/s10803-013-1790-2
PG 13
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500015
PM 23430177
ER
PT J
AU Wainer, AL
Block, N
Donnellan, MB
Ingersoll, B
AF Wainer, Allison L.
Block, Nicole
Donnellan, M. Brent
Ingersoll, Brooke
TI The Broader Autism Phenotype and Friendships in Non-clinical Dyads
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Broader autism phenotype; Friendships; Actor-partner interdependence
model
ID SPECTRUM QUOTIENT AQ; SELF-OTHER AGREEMENT; PERSONALITY-TRAITS;
GENERAL-POPULATION; MULTIPLE-INCIDENCE; RELATIONSHIP SATISFACTION;
MARITAL SATISFACTION; FUNCTIONING AUTISM; YOUNG-ADULTS; SIMILARITY
AB The broader autism phenotype (BAP) is a set of subclinical traits qualitatively similar to those observed in autism spectrum disorders. The current study sought to elucidate the association between self- and informant-reports of the BAP and friendships, in a non-clinical sample of college student dyads. Self-informant agreement of the BAP and friendship similarity was evaluated, and the Actor-Partner Interdependence Model was used to test how both friends' BAP characteristics jointly and uniquely contribute to the experiences of friendships. Results suggest self-informant agreement about the BAP, friendship closeness, quality, and conflict. Actor effects were observed for the BAP and friendship values, quality, conflict, and loneliness. Findings suggest that the BAP relates in meaningful ways to self-perceptions of friendship variables in the general population.
C1 [Wainer, Allison L.; Block, Nicole; Donnellan, M. Brent; Ingersoll, Brooke] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA.
RP Wainer, AL (reprint author), Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA.
EM waineral@msu.edu; ingers19@msu.edu
RI Ingersoll, Brooke/A-9117-2012
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American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 48
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2418
EP 2425
DI 10.1007/s10803-013-1789-8
PG 8
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500016
PM 23430176
ER
PT J
AU Dykens, EM
Lambert, W
AF Dykens, Elisabeth M.
Lambert, Warren
TI Trajectories of Diurnal Cortisol in Mothers of Children with Autism and
Other Developmental Disabilities: Relations to Health and Mental Health
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Diurnal cortisol; Mothers of children with disabilities; Health; Mental
health
ID INTELLECTUAL DISABILITIES; STRESS; ADULTS; WOMEN; DISORDERS; BEHAVIORS;
PATTERNS; BENEFITS; PARENTS; MIDLIFE
AB This study used a stress biomarker, diurnal cortisol, to identify how elevated stress in mothers of children and adults with autism and other disabilities relates to their health and mental health. Based on semi-parametric, group-based trajectory analysis of 91 mothers, two distinctive cortisol trajectories emerged: blunted (63 %) or steep (37 %). Mothers in the blunted (vs. steep) trajectory had higher stress levels, lower health ratings, and 89 % of mothers of children with autism, and 53 % with other disabilities, belonged to this trajectory. Atypical cortisol awakening responses and evening rises were differentially associated with anxiety, depression, health problems and employment status. Stress-reducing interventions are needed for parents of children with autism and other disabilities that include biomarkers as indices of risk or treatment outcome.
C1 [Dykens, Elisabeth M.; Lambert, Warren] Vanderbilt Univ, Dept Psychol & Human Dev, Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
[Dykens, Elisabeth M.; Lambert, Warren] Vanderbilt Univ, Dept Pediat, Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
[Dykens, Elisabeth M.; Lambert, Warren] Vanderbilt Univ, Dept Psychiat, Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
RP Dykens, EM (reprint author), Vanderbilt Univ, Dept Psychol & Human Dev, Vanderbilt Kennedy Ctr, 1 Magnolia Circle,Peabody Box 40, Nashville, TN 37203 USA.
EM elisabeth.dykens@vanderbilt.edu
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NR 43
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2426
EP 2434
DI 10.1007/s10803-013-1791-1
PG 9
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500017
PM 23468069
ER
PT J
AU Reichow, B
Volkmar, FR
Bloch, MH
AF Reichow, Brian
Volkmar, Fred R.
Bloch, Michael H.
TI Systematic Review and Meta-analysis of Pharmacological Treatment of the
Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with
Pervasive Developmental Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Pervasive developmental disorder; Attention
deficit/hyperactivity disorder; Methylphenidate; Meta-analysis;
Atomoxetine; Clonidine; ADHD; ASD; Autism spectrum disorder; PDD;
PDD-NOS
ID AUTISM-SPECTRUM DISORDERS; DEFICIT HYPERACTIVITY DISORDER;
PSYCHIATRIC-DISORDERS; MEDICATION USE; METHYLPHENIDATE; ADOLESCENTS;
ATOMOXETINE; CROSSOVER; EFFICACY; PLACEBO
AB Many children with pervasive developmental disorders (PDD) exhibit behaviors and symptoms of attention-deficit/hyperactivity disorder (ADHD). We sought to determine the relative efficacy of medications for treating ADHD symptoms in children with PDD by identifying all double-blind, randomized, placebo-controlled trials examining the efficacy of medications for treating ADHD symptoms in children with PDD. We located seven trials involving 225 children. A random effects meta-analysis of four methylphenidate trials showed methylphenidate to be effective for treating ADHD symptoms in children with PDD (ES = .67). Several adverse events were greater for children were taking methylphenidate compared to placebo. An individual trial of clonidine and two trials of atomoxetine suggest these agents may also be effective in treating ADHD symptoms in children with PDD.
C1 [Reichow, Brian; Volkmar, Fred R.; Bloch, Michael H.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06519 USA.
RP Reichow, B (reprint author), Yale Univ, Sch Med, Ctr Child Study, 230 South Frontage Rd, New Haven, CT 06519 USA.
EM brian.reichow@yale.edu
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NR 41
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2435
EP 2441
DI 10.1007/s10803-013-1793-z
PG 7
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500018
PM 23468071
ER
PT J
AU Caamano, M
Boada, L
Merchan-Naranjo, J
Moreno, C
Llorente, C
Moreno, D
Arango, C
Parellada, M
AF Caamano, Marta
Boada, Leticia
Merchan-Naranjo, Jessica
Moreno, Carmen
Llorente, Cloe
Moreno, Dolores
Arango, Celso
Parellada, Mara
TI Psychopathology in Children and Adolescents with ASD Without Mental
Retardation
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Asperger syndrome; Psychopathology; Comorbidity; Adolescent;
Developmental disorders
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME;
PSYCHIATRIC-SYMPTOMS; SCHEDULE
AB This study analyzes subclinical psychopathology in children and adolescents with autism spectrum disorders (ASD) without mental retardation with no comorbid disorder, assessed by an extensive general psychopathology interview. The K-SADS-PL was administered to a group of 25 patients with ASD (mean age = 12.80 +/- A 2.86 years) and 25 healthy controls (mean age 12.52 +/- A 2.86 years). Significant differences were found between patients with ASD and controls for the domains of: depressive disorder, anxiety separation disorder, agoraphobia and specific phobias, obsessive compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD). In patients without a comorbid disorder, we found a profile of subclinical disturbances that suggest high risk for comorbid psychiatric conditions derived from the presence of subthreshold symptomatology.
C1 [Caamano, Marta; Boada, Leticia; Merchan-Naranjo, Jessica; Moreno, Carmen; Llorente, Cloe; Moreno, Dolores; Arango, Celso; Parellada, Mara] Hosp Gen Univ Gregorio Maranon, Dept Psychiat, Madrid 28009, Spain.
[Caamano, Marta; Boada, Leticia; Merchan-Naranjo, Jessica; Moreno, Carmen; Llorente, Cloe; Moreno, Dolores; Arango, Celso; Parellada, Mara] Hosp Gen Univ Gregorio Maranon, Child & Adolescent Psychiat Dept, Ctr Invest Biomed Red Salud Mental, CIBERSAM,IISGM, Madrid 28009, Spain.
[Arango, Celso] Univ Complutense, Fac Med, E-28040 Madrid, Spain.
RP Caamano, M (reprint author), Hosp Gen Univ Gregorio Maranon, Child & Adolescent Psychiat Dept, Ctr Invest Biomed Red Salud Mental, CIBERSAM,IISGM, C Ibiza 43, Madrid 28009, Spain.
EM marta.caamano@hotmail.com
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NR 25
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2442
EP 2449
DI 10.1007/s10803-013-1792-0
PG 8
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500019
PM 23468070
ER
PT J
AU Storch, EA
Sulkowski, ML
Nadeau, J
Lewin, AB
Arnold, EB
Mutch, PJ
Jones, AM
Murphy, TK
AF Storch, Eric A.
Sulkowski, Michael L.
Nadeau, Josh
Lewin, Adam B.
Arnold, Elysse B.
Mutch, P. Jane
Jones, Anna M.
Murphy, Tanya K.
TI The Phenomenology and Clinical Correlates of Suicidal Thoughts and
Behaviors in Youth with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Suicide; Autism spectrum disorders; Pervasive developmental disorder;
Asperger's disorder; Depression
ID HIGH-FUNCTIONING CHILDREN; ANXIETY DISORDERS; CONTROLLED-TRIAL;
INTELLECTUAL DISABILITY; DEVELOPMENTAL DISORDERS; INTERVIEW SCHEDULE;
DSM-IV; ADOLESCENTS; DEPRESSION; SYMPTOMS
AB This study investigated the phenomenology and clinical correlates of suicidal thoughts and behaviors in youth with ASD (N = 102; range 7-16 years). The presence of suicidal thoughts and behavior was assessed through the Anxiety Disorders Interview Schedule-Child and Parent Versions. Children and parents completed measures of anxiety severity, functional impairment, and behavioral and emotional problems. Approximately 11 % of youth displayed suicidal thoughts and behaviors. Children with autism were more likely to have suicidal thoughts and behaviors whereas children with Asperger's disorder were less likely. Suicidal thoughts and behaviors were associated with the presence of depression and post-traumatic stress disorder. Overall, results suggest that suicidal thoughts and behaviors are common in youth with ASD, and may be related to depression and trauma.
C1 [Storch, Eric A.; Nadeau, Josh; Lewin, Adam B.; Arnold, Elysse B.; Mutch, P. Jane; Jones, Anna M.; Murphy, Tanya K.] Univ S Florida, Dept Pediat, Rothman Ctr Neuropsychiat, St Petersburg, FL 33701 USA.
[Storch, Eric A.; Lewin, Adam B.; Murphy, Tanya K.] Univ S Florida, Dept Psychiat & Neurosci, St Petersburg, FL 33701 USA.
[Sulkowski, Michael L.] Univ Arizona, Dept Disabil & Psychoeduc Studies, Tucson, AZ USA.
RP Storch, EA (reprint author), Univ S Florida, Dept Pediat, Rothman Ctr Neuropsychiat, 880 6th St South,4th Floor Suite 460,Box 7523, St Petersburg, FL 33701 USA.
EM estorch@health.usf.edu
RI Nadeau, Joshua/F-1462-2015
OI Nadeau, Joshua/0000-0002-9886-4709
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NR 79
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2450
EP 2459
DI 10.1007/s10803-013-1795-x
PG 10
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500020
PM 23446993
ER
PT J
AU Fulton, ML
D'Entremont, B
AF Fulton, Mandy L.
D'Entremont, Barbara
TI Utility of the Psychoeducational Profile-3 for Assessing Cognitive and
Language Skills of Children with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Psychoeducational Profile-3; Psychometric
properties; Diagnostic symptomatology
ID PERVASIVE DEVELOPMENTAL DISORDERS; ADAPTIVE-BEHAVIOR SCALES;
PRESCHOOL-CHILDREN; RELIABILITY; INDIVIDUALS; ACQUISITION; SCHEDULE;
VALIDITY; ABILITY; VERSION
AB The Psychoeducational Profile-3's (PEP-3) ability to estimate cognitive and language skills of 136 children (20-75 months) with autism spectrum disorders (ASDs) across a range of functioning, and the association between the PEP-3 and ASD symptomatology was examined using retrospective data. PEP-3 cognitive and language measures were positively correlated with similar measures on the Child Development Inventory, the Merrill-Palmer Revised, and the Vineland Adaptive Behaviour Scale-2. The PEP-3 sometimes provided higher or lower estimates than other measures. Significant differences were found between diagnostic groups on PEP-3 cognitive and language measures. PEP-3 cognitive scores correlated positively with scores on the Autism Diagnostic Observation Schedule. Findings support the use of the PEP-3 to measure cognition and language in children with ASDs.
C1 [Fulton, Mandy L.; D'Entremont, Barbara] Univ New Brunswick, Fredericton, NB E3B 5A3, Canada.
RP Fulton, ML (reprint author), Univ New Brunswick, POB 4400, Fredericton, NB E3B 5A3, Canada.
EM t533z@unb.ca
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NR 58
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2460
EP 2471
DI 10.1007/s10803-013-1794-y
PG 12
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500021
PM 23446992
ER
PT J
AU Strickland, DC
Coles, CD
Southern, LB
AF Strickland, Dorothy C.
Coles, Claire D.
Southern, Louise B.
TI JobTIPS: A Transition to Employment Program for Individuals with Autism
Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Interviewing; JobTIPS; Employment; Theory of Mind
ID HIGH-FUNCTIONING AUTISM; SOCIAL-SKILLS; VIRTUAL-REALITY; POSTSECONDARY
EDUCATION; SITUATIONAL INTERVIEW; YOUNG-ADULTS; CHILDREN; VALIDITY;
INTERVENTIONS; METAANALYSIS
AB This study evaluated the effectiveness of an internet accessed training program that included Theory of Mind-based guidance, video models, visual supports, and virtual reality practice sessions in teaching appropriate job interview skills to individuals with high functioning Autism Spectrum Disorders. In a randomized study, twenty-two youth, ages 16-19, were evaluated during two employment interviews. Half received a training intervention following the initial interview and the half who served as a contrast group did not. Their performance pre and post intervention was assessed by four independent raters using a scale that included evaluation of both Content and Delivery. Results suggest that youth who completed the JobTIPS employment program demonstrated significantly more effective verbal content skills than those who did not.
C1 [Strickland, Dorothy C.] Virtual Real Aids Do2Learn, Raleigh, NC 27607 USA.
[Coles, Claire D.] Emory Univ, Dept Psychiat & Behav Sci, Sch Med, Atlanta, GA USA.
[Coles, Claire D.] Marcus Autism Ctr, Dept Pediat, Atlanta, GA USA.
[Southern, Louise B.] N Carolina State Univ, Raleigh, NC 27607 USA.
RP Strickland, DC (reprint author), Virtual Real Aids Do2Learn, 3204 Churchill Rd, Raleigh, NC 27607 USA.
EM strickland@do2learn.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baron-Cohen Simon, 2000, UNDERSTANDING OTHER
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NR 43
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2472
EP 2483
DI 10.1007/s10803-013-1800-4
PG 12
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500022
PM 23494559
ER
PT J
AU Peters, SU
Hundley, RJ
Wilson, AK
Carvalho, CMB
Lupski, JR
Ramocki, MB
AF Peters, S. U.
Hundley, R. J.
Wilson, A. K.
Carvalho, C. M. B.
Lupski, J. R.
Ramocki, M. B.
TI Brief Report: Regression Timing and Associated Features in MECP2
Duplication Syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Regression; MECP2; Seizures
ID AUTISM SPECTRUM DISORDERS; MENTAL-RETARDATION; RETT-SYNDROME; PHENOTYPE;
PATTERNS; FEMALES; ONSET; CPEA; XQ28
AB The aim of this study was to determine the frequency, timing, and associated features of developmental regression in MECP2 duplication syndrome. We also examined whether duplication size was associated with regression. Comprehensive psychological evaluations were used to assess 17 boys with MECP2 duplication syndrome. Information about regression was gathered via parent report. Eight of 17 boys exhibited regression in language skills, while seven of 17 exhibited regression in other skill areas. Regression in "other skill" areas coincided with seizure onset and with a prior autism diagnosis in six of seven participants. Regression was not associated with duplication size. Questions remain as to why some boys regress, and future work is necessary to understand the underlying mechanism(s) that causes regression.
C1 [Peters, S. U.; Hundley, R. J.] Vanderbilt Univ, Dept Pediat, Nashville, TN USA.
[Peters, S. U.; Hundley, R. J.] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37235 USA.
[Peters, S. U.; Hundley, R. J.; Wilson, A. K.] Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37203 USA.
[Carvalho, C. M. B.; Lupski, J. R.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Ramocki, M. B.] Baylor Coll Med, Dept Pediat, Sect Pediat Neurol & Dev Neurosci, Houston, TX 77030 USA.
RP Peters, SU (reprint author), Vanderbilt Kennedy Ctr Res Human Dev, PMB 74 230 Appleton Pl, Nashville, TN 37203 USA.
EM sarika.u.peters@vanderbilt.edu
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Yang TS, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004430
NR 23
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD OCT
PY 2013
VL 43
IS 10
BP 2484
EP 2490
DI 10.1007/s10803-013-1796-9
PG 7
WC Psychology, Developmental
SC Psychology
GA 217FD
UT WOS:000324341500023
PM 23456562
ER
PT J
AU Gourley, L
Wind, C
Henninger, EM
Chinitz, S
AF Gourley, Lauren
Wind, Carina
Henninger, Erin M.
Chinitz, Susan
TI Sensory Processing Difficulties, Behavioral Problems, and Parental
Stress in a Clinical Population of Young Children
SO JOURNAL OF CHILD AND FAMILY STUDIES
LA English
DT Article
DE Sensory processing disorder; Short sensory profile; Parental stress;
Behavioral difficulties; Preschool aged children
ID DEFICIT-HYPERACTIVITY DISORDER; ELECTRODERMAL RESPONSES;
OVER-RESPONSIVITY; EVERYDAY LIFE; FAMILIES; PREVALENCE; TODDLERS;
PROFILE; AUTISM; IMPACT
AB This study examined the relationship between sensory processing difficulties, parental stress, and behavioral problems in a clinical sample of young children with developmental and behavioral difficulties. We hypothesized that a high rate of sensory processing difficulties would be found, that there would be a high rate of comorbidity between sensory processing difficulties and behavioral problems, and that children's sensory processing difficulties and parental stress would be highly correlated. Parents of 59 children ages two to five who attended an out-patient clinic in a low income, urban community completed the Child Behavior Checklist, Parental Stress Inventory-Short Form and the Short Sensory Profile. Children in this clinical population showed a high prevalence (55.9 %) of sensory processing difficulties, a significantly higher rate than previously reported. Sensory processing deficits were correlated with behavioral difficulties and parental stress levels-suggesting that as sensory processing difficulties increase, so do behavioral difficulties and parental stress. Parents of children with sensory processing deficits had significantly higher levels of parental stress than parents of children without sensory deficits. Parenting stress levels were also clinically elevated for the cohort of children in which sensory processing difficulties and behavioral concerns co-existed. These findings suggest that treatment outcomes might improve and parental stress could be reduced if mental health clinicians were trained to identify and address sensory problems. This could result in more children being screened and treated for sensory processing difficulties and an eventual reduction in the rates of parental stress.
C1 [Gourley, Lauren; Wind, Carina; Henninger, Erin M.; Chinitz, Susan] Yeshiva Univ Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA.
[Gourley, Lauren; Wind, Carina; Henninger, Erin M.; Chinitz, Susan] Early Childhood Ctr, Bronx, NY 10461 USA.
RP Gourley, L (reprint author), Yeshiva Univ Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA.
EM lauren.gourley@einstein.yu.edu
CR Abidin RR, 1995, PARENTING STRESS IND
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Talay-Ongan A., 2000, INT J DISABIL DEV ED, V47, P201, DOI DOI 10.1080/713671112
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Yeo RA, 2003, J AM ACAD CHILD PSY, V42, P303, DOI 10.1097/01.CHI.0000037024.34553.1B
NR 42
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1062-1024
J9 J CHILD FAM STUD
JI J. Child Fam. Stud.
PD OCT
PY 2013
VL 22
IS 7
BP 912
EP 921
DI 10.1007/s10826-012-9650-9
PG 10
WC Family Studies; Psychology, Developmental; Psychiatry
SC Family Studies; Psychology; Psychiatry
GA 216AQ
UT WOS:000324253600004
ER
PT J
AU Ecker, C
Spooren, W
Murphy, D
AF Ecker, C.
Spooren, W.
Murphy, D.
TI Developing new pharmacotherapies for autism
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE autism; biomarkers; drug development; personalized medicine;
translational research
ID SPECTRUM DISORDERS; NEURODEVELOPMENTAL DISORDERS; NEUROPSYCHIATRIC
DISORDERS; MENTAL-RETARDATION; BRAIN-SEROTONIN; EARLY-LIFE; ADULTS;
DYSFUNCTION; GLUTAMATE; CHILDREN
AB Developing new pharmacotherapies for autism spectrum disorder (ASD) is a challenge. ASD has a complex genetic architecture, several neurobiological phenotypes and multiple symptom domains. However, new opportunities are emerging that could lead to the development of targeted' and individualized pharmacological interventions. Here, first we review these important new insights into the aetiology and neurobiology of ASD with particular focus on (i) genetic variants mediating synaptic structure and functioning and (ii) differences in brain anatomy, chemistry and connectivity in this condition. The characterization of the genotypic and phenotypic differences underlying ASD might in the future be invaluable for stratifying the large range of different individuals on the autism spectrum into genetically and/or biologically homogeneous subgroups that might respond to similar targeted interventions. Secondly, we propose a strategic framework for the development of targeted pharmacotherapies for ASD, which comprises several different stages in which research findings are translated into clinical applications. The establishment of animal models and cellular assays is important for developing and testing new pharmacological targets before initiating large-scale clinical trials. Finally, we present the European Autism Interventions - A Multicentre Study for Developing New Medications (EU-AIMS) Initiative, which was set up in the context of the EU Innovative Medicines Initiative as the first European platform for integrated translational research in ASD. The EU-AIMS Initiative consists of academic and industrial partners working in collaboration to deliver a more personalized' approach to diagnosing and treating ASD in the future.
C1 [Ecker, C.; Murphy, D.] Inst Psychiat, Dept Forens & Neurodev Sci, London SE5 8AF, England.
[Spooren, W.] F Hoffmann La Roche Ltd, Basel, Switzerland.
RP Ecker, C (reprint author), Inst Psychiat, Dept Forens & Neurodev Sci, De Crespigny Pk, London SE5 8AF, England.
EM Christine.ecker@kcl.ac.uk
RI Ecker, Christine/E-5194-2010
FU Autism Imaging Multicentre Study (AIMS) Consortium; Medical Research
Council, UK [G0400061]; Innovative Medicines Initiative Joint
Undertaking [115300]; EU; Autism Speaks; Dr. Mortimer and Theresa
Sackler Foundation; NIHR Biomedical Research Centre for Mental Health at
King's College London, Institute of Psychiatry; South London and
Maudsley NHS Foundation Trust
FX This work was supported by the Autism Imaging Multicentre Study (AIMS)
Consortium funded by the Medical Research Council, UK (G0400061); the
EU-AIMS receiving support from the Innovative Medicines Initiative Joint
Undertaking under grant agreement no. 115300, which includes financial
contributions from the EU Seventh Framework Programme (FP7/2007-2013),
from the EFPIA companies in kind and from Autism Speaks
(http://www.eu-aims.eu); the Dr. Mortimer and Theresa Sackler
Foundation, the NIHR Biomedical Research Centre for Mental Health at
King's College London, Institute of Psychiatry, and South London and
Maudsley NHS Foundation Trust.
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NR 75
TC 6
Z9 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
J9 J INTERN MED
JI J. Intern. Med.
PD OCT
PY 2013
VL 274
IS 4
BP 308
EP 320
DI 10.1111/joim.12113
PG 13
WC Medicine, General & Internal
SC General & Internal Medicine
GA 213OZ
UT WOS:000324068800002
PM 23865950
ER
PT J
AU von Hohenberg, CC
Wigand, MC
Kubicki, M
Leicht, G
Giegling, I
Karch, S
Hartmann, AM
Konte, B
Friedl, M
Ballinger, T
Eckbo, R
Bouix, S
Jager, L
Shenton, ME
Rujescu, D
Mulert, C
AF von Hohenberg, Christian Clemm
Wigand, Marlene C.
Kubicki, Marek
Leicht, Gregor
Giegling, Ina
Karch, Susanne
Hartmann, Annette M.
Konte, Bettina
Friedl, Marion
Ballinger, Thomas
Eckbo, Ryan
Bouix, Sylvain
Jaeger, Lorenz
Shenton, Martha E.
Rujescu, Dan
Mulert, Christoph
TI CNTNAP2 polymorphisms and structural brain connectivity: A
diffusion-tensor imaging study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Caspr2; Genetics; Endophenotype; Magnetic resonance imaging;
Schizophrenia; Autism
ID AUTISM SPECTRUM DISORDERS; WHITE-MATTER; GABAERGIC INTERNEURONS;
NEUREXIN SUPERFAMILY; MYELINATED AXONS; K+ CHANNELS; SCHIZOPHRENIA;
ASSOCIATION; EPILEPSY; GENE
AB CNTNAP2 is a gene on chromosome 7 that has shown associations with autism and schizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we assessed the relationship between Diffusion Tensor Imaging (DTI), a putative marker of anatomical brain connectivity, and multiple single nucleotide polymorphisms (SNPs) spread out over this large gene. 81 healthy controls and 44 patients with schizophrenia (all Caucasian) underwent DTI and genotyping of 31 SNPs within CNTNAP2. We employed Tract-based Spatial Statistics (TBSS) for inter-subject brain registration and computed average diffusivity values for six major white matter tracts. Analyses of Covariance (ANCOVAs) were computed to test for possible associations with genotypes. The strongest association, which survived rigorous Bonferroni correction, was between rs2710126 genotype and Fractional Anisotropy (FA) in the uncinate fasciculus (p = .00003). This anatomical location is particularly interesting given the enriched fronto-temporal expression of CNTNAP2 in the developing brain. For this SNP, no phenotype association has been reported before. There were several further genotype-DTI associations that were nominally significant but did not survive Bonferroni correction, including an association between axial diffusivity in the dorsal cingulum bundle and a region in intron 13 (represented by rs2710102, rs759178, rs2538991), which has previously been reported to be associated with anterior-posterior functional connectivity. We present new evidence about the effects of CNTNAP2 on brain connectivity, whose disruption has been hypothesized to be central to schizophrenia pathophysiology. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [von Hohenberg, Christian Clemm; Wigand, Marlene C.; Kubicki, Marek; Ballinger, Thomas; Eckbo, Ryan; Bouix, Sylvain; Shenton, Martha E.] Brigham & Womens Hosp, Psychiat Neuroimaging Lab, Boston, MA 02215 USA.
[von Hohenberg, Christian Clemm; Wigand, Marlene C.; Kubicki, Marek; Ballinger, Thomas; Eckbo, Ryan; Bouix, Sylvain; Shenton, Martha E.] Harvard Univ, Sch Med, Boston, MA 02215 USA.
[von Hohenberg, Christian Clemm; Wigand, Marlene C.; Giegling, Ina; Karch, Susanne; Hartmann, Annette M.; Konte, Bettina; Friedl, Marion; Rujescu, Dan] Univ Munich, Fac Med, Dept Psychiat, Munich, Germany.
[von Hohenberg, Christian Clemm; Wigand, Marlene C.; Leicht, Gregor; Mulert, Christoph] Univ Med Ctr Hamburg Eppendorf, Psychiat Neuroimaging Branch, Imaging Ctr NeuroImage Nord, Hamburg, Germany.
[von Hohenberg, Christian Clemm; Wigand, Marlene C.; Leicht, Gregor; Mulert, Christoph] Univ Med Ctr Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Hamburg, Germany.
[Kubicki, Marek; Bouix, Sylvain; Shenton, Martha E.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
[Kubicki, Marek; Bouix, Sylvain; Shenton, Martha E.] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA.
[Jaeger, Lorenz] Univ Munich, Fac Med, Dept Radiol, Munich, Germany.
[Shenton, Martha E.] Vet Affairs Boston Healthcare Syst, Brockton Div, Neurosci Lab, Clin Neurosci Div, Brockton, MA USA.
[Rujescu, Dan] Univ Halle Wittenberg, Univ Hosp, Dept Psychiat, Halle, Germany.
[Rujescu, Dan] Univ Halle Wittenberg, Fac Med, Halle, Germany.
RP von Hohenberg, CC (reprint author), Brigham & Womens Hosp, Psychiat Neuroimaging Lab, 1249 Boylston St, Boston, MA 02215 USA.
EM clemm@bwh.harvard.edu
RI Mulert, Christoph/F-2576-2012
FU Deutsche Forschungsgemeinschaft [DFG SFB 936]; National Institutes of
Health [P50 MH 080272, R01 MH082918]; Veterans Affairs Merit Award;
Veterans Affairs Schizophrenia Center Grant; NARSAD Distinguished
Investigator Award
FX This work was supported, in part, by grants from the Deutsche
Forschungsgemeinschaft (DFG SFB 936 to CM, GL); National Institutes of
Health (P50 MH 080272 to MES; R01 MH082918 to SB); Veterans Affairs
Merit Award to MES; Veterans Affairs Schizophrenia Center Grant to MES;
NARSAD Distinguished Investigator Award to MES. The content is solely
the responsibility of the authors and does not necessarily represent the
official views of the National Institutes of Health.
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TC 9
Z9 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD OCT
PY 2013
VL 47
IS 10
BP 1349
EP 1356
DI 10.1016/j.jpsychires.2013.07.002
PG 8
WC Psychiatry
SC Psychiatry
GA 212TC
UT WOS:000324004700010
ER
PT J
AU Miller, BT
Krockover, GH
Doughty, T
AF Miller, Bridget T.
Krockover, Gerald H.
Doughty, Teresa
TI Using iPads to teach inquiry science to students with a moderate to
severe intellectual disability: A pilot study
SO JOURNAL OF RESEARCH IN SCIENCE TEACHING
LA English
DT Article
DE science inquiry; intellectual disabilities; instructional supports
ID SEVERE DEVELOPMENTAL-DISABILITIES; COGNITIVE DISABILITIES; HIGH-SCHOOL;
EDUCATION; INSTRUCTION; COMMUNICATION; STANDARDS; AUTISM; SYSTEM
AB Multiple illustrative case studies were used to investigate guided inquiry methods and the benefits of traditional science notebooks versus electronic science notebooks for students with moderate to severe intellectual disabilities. Results indicated students successfully acquired science content and increased motivation through science inquiry instruction using both methods. However, each student demonstrated higher motivation, engagement, and independence in inquiry investigation with the use of iPad (R) electronic notebooks. (c) 2013 Wiley Periodicals, Inc. J Res Sci Teach 50: 887-911, 2013
C1 [Miller, Bridget T.] Univ S Carolina, Dept Instruct & Teacher Educ, Columbia, SC 29208 USA.
[Krockover, Gerald H.] Purdue Univ, Dept Earth Atmospher & Planetary Sci, W Lafayette, IN 47907 USA.
[Doughty, Teresa] Purdue Univ, Dept Educ Studies, W Lafayette, IN 47907 USA.
RP Miller, BT (reprint author), Univ S Carolina, Dept Instruct & Teacher Educ, Columbia, SC 29208 USA.
EM btmiller@mailbox.sc.edu
RI boran, gul hanim/C-5889-2014
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NR 68
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4308
J9 J RES SCI TEACH
JI J. Res. Sci. Teach.
PD OCT
PY 2013
VL 50
IS 8
BP 887
EP 911
DI 10.1002/tea.21091
PG 25
WC Education & Educational Research
SC Education & Educational Research
GA 214AE
UT WOS:000324101400001
ER
PT J
AU Chapman, CD
Frey, WH
Craft, S
Danielyan, L
Hallschmid, M
Schithoth, HB
Benedict, C
AF Chapman, Colin D.
Frey, William H., II
Craft, Suzanne
Danielyan, Lusine
Hallschmid, Manfred
Schithoth, Helgi B.
Benedict, Christian
TI Intranasal Treatment of Central Nervous System Dysfunction in Humans
SO PHARMACEUTICAL RESEARCH
LA English
DT Review
DE central nervous system; insulin; intranasal administration; oxytocin;
stem cells
ID BLOOD-BRAIN-BARRIER; RANDOMIZED CONTROLLED-TRIAL; INSULIN IMPROVES
MEMORY; PITUITARY-ADRENAL AXIS; MESENCHYMAL STEM-CELLS; IMPAIRED
OLDER-ADULTS; FOOD-INTAKE; NEURODEGENERATIVE DISEASE;
PARKINSONS-DISEASE; STATUS EPILEPTICUS
AB One of the most challenging problems facing modern medicine is how to deliver a given drug to a specific target at the exclusion of other regions. For example, a variety of compounds have beneficial effects within the central nervous system (CNS), but unwanted side effects in the periphery. For such compounds, traditional oral or intravenous drug delivery fails to provide benefit without cost. However, intranasal delivery is emerging as a noninvasive option for delivering drugs to the CNS with minimal peripheral exposure. Additionally, this method facilitates the delivery of large and/or charged therapeutics, which fail to effectively cross the blood-brain barrier (BBB). Thus, for a variety of growth factors, hormones, neuropeptides and therapeutics including insulin, oxytocin, orexin, and even stem cells, intranasal delivery is emerging as an efficient method of administration, and represents a promising therapeutic strategy for the treatment of diseases with CNS involvement, such as obesity, Alzheimer's disease, Parkinson's disease, Huntington's disease, depression, anxiety, autism spectrum disorders, seizures, drug addiction, eating disorders, and stroke.
C1 [Chapman, Colin D.; Schithoth, Helgi B.; Benedict, Christian] Uppsala Univ, Dept Neurosci, Uppsala, Sweden.
[Frey, William H., II] HealthPartners Res Fdn, Reg Hosp, Alzheimers Res Ctr, St Paul, MN USA.
[Craft, Suzanne] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, J Paul Sticht Ctr Aging,Sect Gerontol & Geriatr M, Winston Salem, NC 27157 USA.
[Danielyan, Lusine] Univ Tubingen Hosp, Dept Clin Pharmacol, Tubingen, Germany.
[Hallschmid, Manfred] Univ Tubingen, Dept Med Psychol & Behav Neurobiol, Tubingen, Germany.
RP Chapman, CD (reprint author), Uppsala Univ, Dept Neurosci, Box 593,Husargatan 3, Uppsala, Sweden.
EM colin.chapman@neuro.uu.se
FU Tore Nilsons Foundation; Ingrid Thurings Foundation; Swedish Brain
Foundation; Ake Wiberg Foundation; Olle Engkvist Byggmastare Foundation;
Ahlens Foundation; Swedish Research Council; National Institutes of
Health; Deutsche Forschungsgemeinschaft
FX Work from CC, HS, and CB has been supported by the Tore Nilsons
Foundation, Ingrid Thurings Foundation, the Swedish Brain Foundation,
Ake Wiberg Foundation, Olle Engkvist Byggmastare Foundation, Ahlens
Foundation, and the Swedish Research Council. Work from WF and SC has
been supported by the National Institutes of Health. Work from WF has
also been supported by numerous pharmaceutical companies. Further, WF is
the listed inventor on many patents (101-104) related to the use of
intranasal drugs, biopharmaceuticals and, in combination with LD,
therapeutic stem cells to treat CNS disorders. Work from MH has been
supported by the Deutsche Forschungsgemeinschaft. The authors have no
conflicts of interest that are directly relevant to the content of this
article.
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PU SPRINGER/PLENUM PUBLISHERS
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PY 2013
VL 30
IS 10
BP 2475
EP 2484
DI 10.1007/s11095-012-0915-1
PG 10
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
SC Chemistry; Pharmacology & Pharmacy
GA 213RC
UT WOS:000324074800005
PM 23135822
ER
PT J
AU Volaki, K
Pampanos, A
Kitsiou-Tzeli, S
Vrettou, C
Oikonomakis, V
Sofocleous, C
Kanavakis, E
AF Volaki, Konstantina
Pampanos, Andreas
Kitsiou-Tzeli, Sophia
Vrettou, Christina
Oikonomakis, Vasilis
Sofocleous, Christalena
Kanavakis, Emmanuel
TI Mutation screening in the Greek population and evaluation of NLGN3 and
NLGN4X genes causal factors for autism
SO PSYCHIATRIC GENETICS
LA English
DT Article
DE autism; mutation detection; NLGN3; NLGN4X
ID MOLECULAR CYTOGENETIC ANALYSIS; STEROID SULFATASE DEFICIENCY;
MENTAL-RETARDATION; NEUROLIGIN GENES; VARIABLE PHENOTYPE; SPECTRUM
DISORDER; SYNAPSE FORMATION; DELETION; EXPRESSION; VARIANTS
AB Molecular and neurobiological evidence for the involvement of neuroligins (particularly NLGN3 and NLGN4X genes) in autistic disorder is accumulating. However, previous mutation screening studies on these two genes have yielded controversial results. The present study explores, for the first time, the contribution of NLGN3 and NLGN4X genetic variants in Greek patients with autistic disorder. We analyzed the full exonic sequence of NLGN3 and NLGN4X genes in 40 patients strictly fulfilling the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. criteria for autistic disorder. We identified nine nucleotide changes in NLGN4X - one probable causative mutation (p.K378R) previously reported by our research group, one novel variant (c.-206G>C), one nonvalidated single nucleotide polymorphism (SNP, rs111953947), and six known human SNPs reported in the SNP database - and one known human SNP in NLGN3 also reported in the SNP database. The variants identified are expected to be benign. However, they should be investigated in the context of variants in interacting cellular pathways to assess their contribution to the etiology of autism. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Volaki, Konstantina; Pampanos, Andreas; Kitsiou-Tzeli, Sophia; Vrettou, Christina; Oikonomakis, Vasilis; Sofocleous, Christalena; Kanavakis, Emmanuel] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Med Genet, GR-11527 Athens, Greece.
[Kanavakis, Emmanuel] Aghia Sophia Childrens Hosp, Univ Res Inst Study Genet & Malignant Disorders C, Athens, Greece.
RP Volaki, K (reprint author), Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Med Genet, GR-11527 Athens, Greece.
EM tina.volaki@gmail.com
FU National and Kapodistrian University of Athens; University Research
Institute for the Study of Genetic and Malignant Disorders in Childhood;
National and Kapodistrian University of Athens [70/4/6524]
FX This study was funded by the National and Kapodistrian University of
Athens and the University Research Institute for the Study of Genetic
and Malignant Disorders in Childhood. Konstantina Volaki, Andreas
Pampanos, and Sophia Kitsiou-Tzeli have received funding for this
research work from the National and Kapodistrian University of Athens
[research code number: 70/4/6524 (11/12/2009)]. Emmanuel Kanavakis has
received funding from the University Research Institute for the Study of
Genetic and Malignant Disorders in Childhood. The remaining authors did
not receive funding for this research. The authors thank all the
families and professionals who participated in this study. They also
thank the neurologists and psychiatrists from around the country for the
referrals of the patients who participated in this study.
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NR 50
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0955-8829
J9 PSYCHIAT GENET
JI Psychiatr. Genet.
PD OCT
PY 2013
VL 23
IS 5
BP 198
EP 203
DI 10.1097/YPG.0b013e3283643644
PG 6
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 211DH
UT WOS:000323884200003
PM 23851596
ER
PT J
AU Hashemi, F
Tekes, K
Laufer, R
Szegi, P
Tothfalusi, L
Csaba, G
AF Hashemi, F.
Tekes, Kornelia
Laufer, R.
Szegi, P.
Tothfalusi, L.
Csaba, G.
TI Effect of a Single Neonatal Oxytocin Treatment (Hormonal Imprinting) on
the Biogenic Amine Level of the Adult Rat Brain: Could Oxytocin-Induced
Labor Cause Pervasive Developmental Diseases?
SO REPRODUCTIVE SCIENCES
LA English
DT Article
DE oxytocin; hormonal imprinting; neonatal treatments; parturition; autism
ID AUTISM SPECTRUM DISORDERS; VITAMIN-D TREATMENT; PRAIRIE VOLES;
BEHAVIORAL-DISORDERS; SEROTONIN LEVEL; SEXUAL-BEHAVIOR; RECEPTORS;
METABOLITES; PHYLOGENY; EVOLUTION
AB Perinatal single-hormone treatment causes hormonal imprinting with lifelong consequences in receptor-binding capacity, hormone production as well as in social and sexual behavior. In the present experiments, newborn rats were treated with a single dose of oxytocin, and the levels of biogenic amines and their metabolites were studied in 8 different brain regions and in the sera when the male and female animals were 4 months old. Both dopaminergic and serotonergic neurotransmission was found to be significantly influenced. The levels of 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindole acetic acid metabolites decreased in the hypothalamus and striatum. Dopamine, serotonin, norepinephrine, and 5-hydroxytryptophol levels were hardly altered, and there was no difference in the epinephrine levels. The results show that dopamine and serotonin metabolism of hypothalamus and striatum are deeply and lifelong influenced by a single neonatal oxytocin treatment Oxytocin imprinting resulted in decreased dopamine turnover in the hypothalamus and decreased serotonin turnover in the hypothalamus, medulla oblongata, and striatum of females. As the disturbance of brain dopamine and serotonin system has an important role in the development of pervasive developmental diseases (eg, autism) and neuropsychiatric disorders (eg, schizophrenia), the growing number of oxytocin-induced labor as a causal factor, cannot be omitted.
C1 [Hashemi, F.; Tekes, Kornelia; Laufer, R.; Szegi, P.; Tothfalusi, L.] Semmelweis Univ, Dept Pharmacodynam, H-1445 Budapest, Hungary.
[Csaba, G.] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1445 Budapest, Hungary.
RP Csaba, G (reprint author), Semmelweis Univ, Dept Genet Cell & Immunobiol, POB 370, H-1445 Budapest, Hungary.
EM csagyor@dgci.sote.hu
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NR 52
TC 5
Z9 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1933-7191
J9 REPROD SCI
JI Reprod. Sci.
PD OCT
PY 2013
VL 20
IS 10
BP 1255
EP 1263
DI 10.1177/1933719113483010
PG 9
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 213FL
UT WOS:000324040200016
PM 23548412
ER
PT J
AU Paynter, J
Riley, E
Beamish, W
Davies, M
Milford, T
AF Paynter, Jessica
Riley, Emma
Beamish, Wendi
Davies, Michael
Milford, Todd
TI The double ABCX model of family adaptation in families of a child with
an autism spectrum disorder attending an Australian early intervention
service
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Family adaptation; Early intervention
ID SCHOOL-AGE-CHILDREN; PRESCHOOL-CHILDREN; BEHAVIOR PROBLEMS; PARENTING
STRESS; ASPERGER-SYNDROME; SOCIAL SUPPORT; INTELLECTUAL DISABILITY;
SYNDROME SPECIFICITY; DEVELOPMENTAL DELAY; COPING STRATEGIES
AB It is well established that families caring for a child with an autism spectrum disorder (ASD) experience increased psychological distress compared to other families (e.g., Baker-Ericzen, Brookman-Frazee, & Stahmer, 2005; Lee et al., 2009). However, little research has captured the range of variables linked to family outcomes, and research in the early childhood period has been largely atheoretical. The current study sought to investigate the applicability of the double ABCX Model of Family Adaptation (McCubbin & Patterson, 1983) in understanding the factors underlying family outcomes when children with ASD attend early intervention. Participants included 43 parents (18 males, 25 females) of children aged 2.5 to 6 years (M=49.35, SD = 9.21 months; 8 female, 35 male) with ASD who were attending an autism-specific intervention service. Participants completed standardised questionnaire measures of constructs of the double ABCX Model. As predicted by the model, family systems outcomes (individual, relationship, or family) were linked to symptom severity (challenging behaviour), pile-up demands, internal and external resources, appraisals, and active-avoidant coping styles. Level of ASD symptoms however, were not significantly linked to outcomes. Limitations, directions for future research, and practical implications are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Paynter, Jessica; Riley, Emma] AEIOU Fdn, Res & Psychol Dept, Brisbane, Qld 4111, Australia.
[Beamish, Wendi; Davies, Michael; Milford, Todd] Griffith Univ, Sch Educ & Profess Studies, Brisbane, Qld 4122, Australia.
RP Paynter, J (reprint author), AEIOU Fdn, Res & Psychol Dept, Moorooka Campus,66 Hamilton Rd, Brisbane, Qld 4111, Australia.
EM jessica.paynter@aeiou.org.au; emma.riley@aeiou.org.au;
w.beamish@griffith.edu.au; m.davies@griffith.edu.au;
t.milford@griffith.edu.au
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NR 66
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1183
EP 1195
DI 10.1016/j.rasd.2013.07.006
PG 13
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700001
ER
PT J
AU Lane, BR
Paynter, J
Sharman, R
AF Lane, Ben R.
Paynter, Jessica
Sharman, Rachael
TI Parent and teacher ratings of adaptive and challenging behaviours in
young children with autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; VABS-II; BASC-2; Adaptive behaviour;
Challenging behaviour
ID INFORMANT DISCREPANCIES; INTERVENTIONS; AGREEMENT; ADOLESCENTS; STRESS;
LEVEL
AB This study examined parent and teacher rating correspondence of adaptive and challenging behaviours for children with autism spectrum disorders (ASDs) enrolled in an early intervention program. Data were collected on the Behaviour Assessment System for Children, second edition (BASC-2; n = 22), and Vineland Adaptive Behaviour Scales, second edition (VABS-II; n = 28). Adaptive behaviour ratings generally demonstrated high parent-teacher correlations, while challenging behaviour ratings demonstrated relatively low correlations. Only adaptive skills on the BASC-2 showed significant mean parent-teacher differences, with parent ratings suggesting greater impairment. Results suggest that clinicians should consider gaining both parent and teacher perspectives on a child's challenging behaviour, but that a single informant measure of adaptive behaviour, either parent or teacher, may be sufficient after initial assessments are completed. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Lane, Ben R.; Sharman, Rachael] Univ Sunshine Coast, Maroochydore, Qld 4558, Australia.
[Paynter, Jessica] AEIOU Fdn, Brisbane, Qld 4105, Australia.
RP Lane, BR (reprint author), Univ Sunshine Coast, Sch Social Sci, Locked Bag 4, Maroochydore, Qld 4558, Australia.
EM blane@usc.edu.au; jessica.paynter@aeiou.org.au; rsharman@usc.edu.au
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NR 37
TC 4
Z9 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1196
EP 1203
DI 10.1016/j.rasd.2013.07.011
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700002
ER
PT J
AU Zhang, W
Yan, TT
Du, YS
Liu, XH
AF Zhang, Wei
Yan, Ting-ting
Du, Ya-song
Liu, Xiao-hong
TI Relationship between coping, rumination and posttraumatic growth in
mothers of children with autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Caregiver; Mothers; Rumination; Coping;
Posttraumatic growth
ID QUALITY-OF-LIFE; PRESCHOOL-CHILDREN; BEHAVIOR PROBLEMS; CANCER
SURVIVORS; MENTAL-HEALTH; DOWN-SYNDROME; STRESS; ADOLESCENTS;
CAREGIVERS; SYMPTOMS
AB This study examined the relationship between coping, rumination and posttraumatic growth in mothers of children with autism spectrum disorders (ASD). One hundred and two mothers of autistic children in China were surveyed using Post-traumatic Growth Inventory, Trait Coping Style Questionnaire, and Event Related Rumination Inventory. Mothers reported mediate level of PIG, mostly on the growth of personal strength. Hierarchal regression analysis indicated that positive coping positively predicted PTG and growth on "relating to others"; deliberate rumination was positively correlated with growth on "appreciation of life"; and intrusive rumination negatively predicted growth on "personal strength", "new possibilities" and "spiritual change". No statistically significant relationship between negative coping and PIG was found. The results may be used to provide mothers with a better understanding of the underlying growth process and assist service providers in facilitating this progress. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Zhang, Wei; Yan, Ting-ting; Liu, Xiao-hong] Second Mil Med Univ, Sch Nursing, Shanghai 200433, Peoples R China.
[Du, Ya-song] Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.
RP Liu, XH (reprint author), Second Mil Med Univ, Sch Nursing, 800 Xiangyin Rd, Shanghai 200433, Peoples R China.
EM xhliu@smmu.edu.cn
CR Allik H, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-1
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Zhang W, 2013, RES AUTISM SPECT DIS, V7, P1204, DOI 10.1016/j.rasd.2013.07.008
NR 41
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1204
EP 1210
DI 10.1016/j.rasd.2013.07.008
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700003
ER
PT J
AU Dixon, MR
Whiting, SW
Miller, JR
AF Dixon, Mark R.
Whiting, Seth W.
Miller, Jeffrey R.
TI Discounting of restraint usage, problem behavior management, and risk of
autism severity
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Delay discounting; Probability discounting; Physical restraint; Autism
services; Birth risk
ID SELF-CONTROL; CHALLENGING BEHAVIOR; DELAY; CHILDREN; STUDENTS; SMOKING;
PEOPLE
AB The current study examined whether a history of experience with children with autism affected the rate of discounting of a delayed or probable consequence. Experiment 1 utilized a temporal discounting task to compare the discounting rates of adults who have worked in an autism service setting and have experience with physical restraints to that of adults who have little or no experience with these populations. The results showed that adults with a history of contact with autism made less optimal choices and discounted restraint responsibilities more steeply than adults with no such history, indicating increased avoidance of engaging in restraints. Experiment 2 investigated how the same groups discounted child problem behavior, and showed that those with experience with autism preferred to delay working with children with severe problem behavior and discounted the student's problem behavior more steeply, again demonstrating increased avoidance. Experiment 3 examined risk tendencies in relation to having children with diminished functioning in parents who have children with autism and those who have only worked with them. Results showed that parents made riskier choices than non-parents. Overall, all 3 experiments showed that those with increased experience with children with autism tended toward more impulsive and risky choices. Published by Elsevier Ltd.
C1 [Dixon, Mark R.; Whiting, Seth W.; Miller, Jeffrey R.] So Illinois Univ, Behav Anal & Therapy Program, Inst Rehabil, Carbondale, IL 62901 USA.
RP Dixon, MR (reprint author), So Illinois Univ, Behav Anal & Therapy Program, Inst Rehabil, Carbondale, IL 62901 USA.
EM mdixon@siu.edu
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NR 21
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1211
EP 1220
DI 10.1016/j.rasd.2013.07.004
PG 10
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700004
ER
PT J
AU Erbas, Y
Ceulemans, E
Boonen, J
Noens, I
Kuppens, P
AF Erbas, Yasemin
Ceulemans, Eva
Boonen, Johanna
Noens, Ilse
Kuppens, Peter
TI Emotion differentiation in autism spectrum disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders (ASD); Emotions; Emotion differentiation;
Emotion knowledge; Individual differences
ID HIGH-FUNCTIONING CHILDREN; ASPERGER-SYNDROME; FACIAL EXPRESSIONS;
INDIVIDUALS; RECOGNITION; RELIABILITY; VALIDITY; DEFICITS; MIND
AB Autism spectrum disorder (ASD) is commonly associated with reduced ability to recognize emotions in others. It is less clear however, whether ASD is also associated with impaired knowledge of one's own emotions. In the current study we present a first examination of how much knowledge individuals with ASD have about their emotions by investigating their ability to differentiate between emotions. Across two lab tasks that measured to what extent and how people differentiate between their own feeling states and semantic emotion terms, results showed that ASD individuals differentiated less than typically developing individuals. Yet, both groups of participants similarly categorized emotions according to previously established theoretical categories. These findings indicate that while both give similar meaning to emotions, individuals with ASD make less subtle distinctions between emotions. With low levels of emotion differentiation being linked to reduced well-being, these findings may help to better understand the high prevalence of internalizing problems associated with ASD. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Erbas, Yasemin; Ceulemans, Eva; Boonen, Johanna; Kuppens, Peter] Katholieke Univ Leuven, Fac Psychol & Educ Sci, B-3000 Louvain, Belgium.
[Noens, Ilse] Katholieke Univ Leuven, Parenting & Special Educ Res Unit, B-3000 Louvain, Belgium.
[Noens, Ilse] Katholieke Univ Leuven, Leuven Autism Res, B-3000 Louvain, Belgium.
[Kuppens, Peter] Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic 3010, Australia.
RP Erbas, Y (reprint author), Katholieke Univ Leuven, Dept Psychol, Tiensestr 102,Box 3713, B-3000 Louvain, Belgium.
EM Yasemin.Erbas@ppw.kuleuven.be; Eva.Ceulemans@ppw.kuleuven.be;
Johanna.Boonen@student.kuleuven.be; Ilse.Noens@ppw.kuleuven.be;
Peter.Kuppens@ppw.kuleuven.be
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NR 41
TC 3
Z9 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1221
EP 1227
DI 10.1016/j.rasd.2013.07.007
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700005
ER
PT J
AU Matson, JL
Goldin, RL
AF Matson, Johnny L.
Goldin, Rachel L.
TI Comorbidity and autism: Trends, topics and future directions
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Review
DE Autism spectrum disorders; Comorbidities; Intellectual disabilities;
Co-occurring
ID QUALITY-OF-LIFE; SPECTRUM DISORDERS; DEVELOPMENTAL-DISABILITIES;
CHILDREN; BEHAVIORS; ADOLESCENTS; RELIABILITY; EPILEPSY; TODDLERS;
INFANTS
AB Autism spectrum disorders (ASD) are common, life-long disorders. Symptoms of ASD often co-occur with other difficulties that also tend to be chronic and debilitating. Common co-occurring difficulties include intellectual disabilities, physical conditions, comorbid psychopathologies and challenging behaviors. However, the idea of comorbidities among individuals with ASD is still a relatively new notion. Thus, a new field of research is developing examining comorbidities with ASD. This field is developing rapidly but is still lacking. This paper highlights the most common forms of comorbid disorders, and the future direction of research on comorbidities among individuals with ASD is discussed. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Matson, Johnny L.; Goldin, Rachel L.] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Goldin, RL (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM rgold3@lsu.edu
CR Ali A, 2012, RES DEV DISABIL, V33, P2122, DOI 10.1016/j.ridd.2012.06.013
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Medeiros K, 2012, RES DEV DISABIL, V33, P1110, DOI 10.1016/j.ridd.2012.02.005
Paul R, 2011, J CHILD PSYCHOL PSYC, V52, P588, DOI 10.1111/j.1469-7610.2010.02332.x
Peters-Scheffer N, 2012, RES DEV DISABIL, V33, P1763, DOI 10.1016/j.ridd.2012.04.006
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Wildes JE, 2013, CLIN PSYCHOL REV, V33, P383, DOI 10.1016/j.cpr.2013.01.006
NR 33
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1228
EP 1233
DI 10.1016/j.rasd.2013.07.003
PG 6
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700006
ER
PT J
AU Lanovaz, MJ
Robertson, KM
Soerono, K
Watkins, N
AF Lanovaz, Marc J.
Robertson, Kirsty M.
Soerono, Kara
Watkins, Nicholas
TI Effects of reducing stereotypy on other behaviors: A systematic review
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Review
DE Autism; Collateral behavior; Developmental disabilities; Intervention;
Literature review; Stereotypy
ID PROFOUND MENTAL-RETARDATION; AUTISM SPECTRUM DISORDERS; SELF-STIMULATORY
BEHAVIOR; VOCAL STEREOTYPY; RESPONSE INTERRUPTION; DIFFERENTIAL
REINFORCEMENT; CHALLENGING BEHAVIOR; NONCONTINGENT REINFORCEMENT;
TEACHING-CHILDREN; PHYSICAL EXERCISE
AB Researchers have shown that high levels of stereotypy in individuals diagnosed with autism spectrum disorders were correlated with more significant impairments in social and adaptive functioning. Reducing stereotypy may thus potentially occasion an increase in appropriate social and adaptive behaviors. Hence, the purpose of this systematic review was to examine the effects of reducing stereotypy on engagement in other behaviors. Following a thorough literature search, we identified 60 studies that both reduced engagement in stereotypy and measured engagement in at least one other behavior. We divided the studies into six broad categories: noncontingent reinforcement, differential reinforcement, punishment-based interventions, multiple contingencies, physical exercise, and other antecedent-based interventions. The results of our analyses suggest that reducing stereotypy produces reallocation toward other behaviors, albeit not necessarily appropriate. As such, clinicians and researchers targeting stereotypy should plan to strengthen an appropriate alternative behavior while targeting all response forms of stereotypy for reduction. Moreover, our review suggests that measuring untargeted behaviors when implementing interventions designed to reduce stereotypy may be essential in clinical and research settings. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Lanovaz, Marc J.] Univ Montreal, Ecole Psychoeduc, Montreal, PQ H3C 3J7, Canada.
[Robertson, Kirsty M.; Soerono, Kara] ASD Montreal, Montreal, PQ H4B 2M5, Canada.
[Watkins, Nicholas] Douglas Coll, New Westminster, BC V3L 5B2, Canada.
RP Lanovaz, MJ (reprint author), Univ Montreal, Ecole Psychoeduc, CP 6128,Succ Ctr Ville, Montreal, PQ H3C 3J7, Canada.
EM marc.lanovaz@umontreal.ca
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NR 80
TC 7
Z9 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1234
EP 1243
DI 10.1016/j.rasd.2013.07.009
PG 10
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700007
ER
PT J
AU Liu, T
Breslin, CM
AF Liu, Ting
Breslin, Casey M.
TI Fine and gross motor performance of the MABC-2 by children with autism
spectrum disorder and typically developing children
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Typical; Youth; Fine motor skills; Gross motor skills
ID ASPERGERS-SYNDROME; PRESCHOOL-CHILDREN; YOUNG-CHILDREN; SKILLS;
IMPAIRMENT; COORDINATION; COMPETENCE; DIAGNOSIS; IQ
AB The purpose of this study was to investigate the fine and gross motor performance of children with autism spectrum disorder (ASD) and age-matched typically developing children as measured by the Movement Assessment Battery for Children-2 (MABC-2). Thirty children with ASD (ages 3-16 years, male = 25, female = 5) and 30 age-matched typically developing children (male = 16, female = 14) performed the MABC-2. Group differences on MABC-2 percentile scores were analyzed using descriptive data and one-way ANOVAs. Effect sizes were also calculated for practical significance. Descriptive data showed that all typically developing children were classified in the green zone on MABC-2. However, the majority of children (80%) with ASD were categorized in the red and amber zones suggesting they experienced motor difficulty or were at risk for motor delay. In addition, children with ASD showed significantly lower MABC-2 percentile scores than the typically developing children on manual dexterity, ball skills, and static and dynamic balance, F(1, 59) = 109.043, p < .001, and the effect sizes were large (>.80). In conclusion, children with ASD were delayed in both fine and gross motor skill performance on MABC-2 when compared to their age-matched typically developing children. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Liu, Ting] Texas State Univ San Marcos, San Marcos, TX 78666 USA.
[Breslin, Casey M.] Temple Univ, Philadelphia, PA 19122 USA.
RP Liu, T (reprint author), Texas State Univ San Marcos, Dept Hlth & Human Performance, San Marcos, TX 78666 USA.
EM tingliu@txstate.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baranek G. T., 2005, HDB AUTISM PERVASIVE, VII, P831
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Centers for Disease Control and Prevention, 2013, DAT STAT AUT SPECTR
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Vasileva N., 2012, J SPECIAL ED REHABIL, V13, P55
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NR 41
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1244
EP 1249
DI 10.1016/j.rasd.2013.07.002
PG 6
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700008
ER
PT J
AU Zhao, S
Uono, S
Yoshimura, S
Kubota, Y
Toichi, M
AF Zhao, Shuo
Uono, Shota
Yoshimura, Sayaka
Kubota, Yasutaka
Toichi, Motomi
TI Can gaze-cueing be helpful for detecting sound in autism spectrum
disorder?
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Auditory; Autism spectrum disorder; Cross-modal; Gaze; Joint attention
ID SUPERIOR TEMPORAL SULCUS; SOCIAL-PERCEPTION; EYE GAZE; ATTENTION;
CHILDREN; DIRECTION; MOVEMENT; EMOTION; ADULTS; BRAIN
AB Autism spectrum disorder (ASD) is a developmental disorder characterized by impaired social interaction, including joint attention, but psychological studies generally have reported intact gaze-triggered joint attention in ASD. These studies used a uni-modal paradigm (i.e. visual cue-target pairs) with eyes or faces as cues and letters or dots as targets. However, it has not been determined whether joint attention is impaired under cross-modal conditions in ASD, although cross-modal impairment has been reported. This study investigated joint attention in ASD under cross-modal conditions with gaze stimuli as visual cues and two kinds of sound (social voice or non-social tone) stimuli as targets. The task for the subject was to locate the target sound and click as soon and as accurately as possible. The ASD group was impaired in joint attention when a tone was used as the target, while both groups showed joint attention to a voice. The results suggest that cross-modal joint attention is impaired in the ASD group when the cue-target relationship is weak (i.e. social cue and non-social target) while it is unimpaired when there is a strong cue-target relationship (i.e. social cue and social target). (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Zhao, Shuo; Uono, Shota; Toichi, Motomi] Kyoto Univ, Grad Sch Med, Sch Hlth Sci, Kyoto 6068507, Japan.
[Yoshimura, Sayaka] Kyoto Univ, Grad Sch Med, Dept Psychiat, Kyoto 6068507, Japan.
[Kubota, Yasutaka] Shiga Univ, Hlth & Med Serv Ctr, Shiga, Japan.
[Toichi, Motomi] Org Promoting Dev Disorder Res, Kyoto, Japan.
RP Zhao, S (reprint author), Kyoto Univ, Grad Sch Med, Sch Hlth Sci, Sakyo Ku, 53 Shogoin Kawahara Cho, Kyoto 6068507, Japan.
EM zhaoshuo09@gmail.com
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NR 32
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1250
EP 1256
DI 10.1016/j.rasd.2013.07.001
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700009
ER
PT J
AU Bulkeley, K
Bundy, A
Roberts, J
Einfeld, S
AF Bulkeley, Kim
Bundy, Anita
Roberts, Jacqueline
Einfeld, Stewart
TI ASD intervention research in real world contexts: Refining single case
designs
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Review
DE Autism; Social validity; Repeated measures; Individualized intervention;
Outcome measurement; Intervention fidelity
ID AUTISM SPECTRUM DISORDERS; SUBJECT DESIGNS; PSYCHOSOCIAL INTERVENTIONS;
SOCIAL-COMMUNICATION; TREATMENT FIDELITY; SPECIAL-EDUCATION; PARENTAL
REPORTS; ITEM SCALES; CHILDREN; BEHAVIOR
AB There is a pressing need for intervention research that reflects real world practice to support evidence-based decision making for families, professionals and administrators who support children with ASD. Some of the challenges confronting intervention research are explored, with solutions offered based on single case design methodology. Challenges with single case designs are also outlined and contemporary solutions that are applicable in real world contexts are illustrated in a study by the authors. Research utilizing these strategies may assist with facilitating practitioners to engage in practice-based research to bridge the research to practice gap in intervention with young children with ASD. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Bulkeley, Kim; Bundy, Anita; Einfeld, Stewart] Univ Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia.
[Roberts, Jacqueline] Griffith Univ, Nathan, Qld 4111, Australia.
RP Bulkeley, K (reprint author), Univ Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia.
EM timankim@optusnet.com.au
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NR 54
TC 4
Z9 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1257
EP 1264
DI 10.1016/j.rasd.2013.07.014
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700010
ER
PT J
AU Bennett, KD
Gutierrez, A
Honsberger, T
AF Bennett, Kyle D.
Gutierrez, Anibal
Honsberger, Toby
TI A comparison of video prompting with and without voice-over narration on
the clerical skills of adolescents with Autism
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder; Video prompting; Employment training
ID DAILY LIVING SKILLS; DEVELOPMENTAL-DISABILITIES; INDIVIDUALS; CHILDREN;
ADULTS
AB The purpose of this study was to compare the effects of video prompting with and without voice-over narration on the acquisition of clerical skills among five secondary students with Autism Spectrum Disorder. We used an adapted alternating treatments design consisting of baseline, comparison, and best treatment conditions. Results showed there were negligible differences between video prompting with or without voice-over narration. However, participants indicated differing preferences for one method over the other. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Bennett, Kyle D.] Florida Int Univ, Dept Teaching & Learning, Miami, FL 33199 USA.
[Gutierrez, Anibal] Florida Int Univ, Dept Psychol, Miami, FL 33199 USA.
[Honsberger, Toby] Renaissance Learning Acad, W Palm Beach, FL USA.
RP Bennett, KD (reprint author), Florida Int Univ, Coll Educ, Dept Teaching & Learning, 11200 SW 8th St, Miami, FL 33199 USA.
EM kyle.bennett@fiu.edu
CR Banda DR, 2011, EDUC TRAIN AUTISM DE, V46, P514
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NR 15
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1273
EP 1281
DI 10.1016/j.rasd.2013.07.013
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700012
ER
PT J
AU Koning, C
Magill-Evans, J
Volden, J
Dick, B
AF Koning, Cyndie
Magill-Evans, Joyce
Volden, Joanne
Dick, Bruce
TI Efficacy of cognitive behavior therapy-based social skills intervention
for school-aged boys with autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Cognitive behavior therapy; Social skills; Intervention; ASD; Autism
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; PERCEPTION MEASURE;
CONTROLLED-TRIAL; CHILDREN; ADOLESCENTS; DEFICITS; ANXIETY; ADJUSTMENT;
PROGRAM
AB School-aged children with Autism Spectrum Disorders (ASD) experience significant difficulty with peer interaction. Research to identify the most effective strategies to address this difficulty has increased but more evidence is needed. Cognitive behavior therapy (CBT), which focuses on changing how a person thinks about social situations as well as how he behaves, is a promising approach. This study evaluated the efficacy of a 15 week CBT-based social skills intervention for boys aged 10-12 years diagnosed with an ASD. Boys with average or better IQ and receptive language skills were randomly assigned to either a control (n = 8) or intervention condition (n = 7). During intervention, boys attended weekly 2 h long group sessions focusing on self-monitoring skills, social perception and affective knowledge, conversation skills, social problem-solving, and friendship management skills. Comparison of the outcomes using repeated measures analyses indicated that boys receiving the intervention scored significantly better on measures of social perception, peer interaction, and social knowledge than boys who had not received intervention. There were no differences on general measures of socialization. The manualized intervention used in this study shows promise but replication with larger samples is needed. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
C1 [Koning, Cyndie; Magill-Evans, Joyce; Volden, Joanne] Univ Alberta, Edmonton, AB T6G 2G4, Canada.
[Dick, Bruce] Univ Alberta, Edmonton, AB T6G 2G3, Canada.
RP Koning, C (reprint author), Glenrose Rehabil Hosp, 10230-111 Ave, Edmonton, AB T5G 0B7, Canada.
EM Cyndie.Koning@albertahealthservices.ca; Joyce.magill-Evans@ualberta.ca;
Joanne.volden@ualberta.ca; Bruce.Dick@ualberta.ca
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Wuensch K. L, 2009, STANDARDIZED EFFECT
NR 60
TC 4
Z9 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD OCT
PY 2013
VL 7
IS 10
BP 1282
EP 1290
DI 10.1016/j.rasd.2011.07.011
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 218SB
UT WOS:000324451700013
ER
PT J
AU Johnels, JA
Hagberg, B
Gillberg, C
Miniscalco, C
AF Johnels, Jakob Asberg
Hagberg, Bibbi
Gillberg, Christopher
Miniscalco, Carmela
TI Narrative retelling in children with neurodevelopmental disorders: Is
there a role for nonverbal temporal-sequencing skills?
SO SCANDINAVIAN JOURNAL OF PSYCHOLOGY
LA English
DT Article
DE Narrative; language impairment; autism; ADHD; temporal sequencing;
ESSENCE; bus story test
ID LANGUAGE IMPAIRMENT; STORY COMPREHENSION; WORKING-MEMORY; DEFICITS;
PERSISTENT; ABILITIES; COHERENCE; SPEECH; BOYS
AB Oral narrative retelling is often problematic for children with communicative and neurodevelopmental disorders. However, beyond a suggested role of language level, little is known about the basis of narrative performance. In this study we examine whether oral narrative retelling might be associated not just with language level but also with skills related to nonverbal narrative temporal sequencing. A diagnostically heterogeneous sample of Swedish-speaking children with a full scale IQ >70 was included in the study (N=55; age 6-9years). Narrative retelling skills were measured using the three subscores from the bus story test (BST). Independent predictors included (1) temporal sequencing skills according to a picture arrangement test and (2) a language skills factor consisting of definitional vocabulary and receptive grammar. Regression analyses show that language skills predicted BST Sentence Length and Subordinate Clauses subscores, while both temporal sequencing and language were independently linked with the BST Information subscore. When subdividing the sample based on nonverbal temporal sequencing level, a significant subgroup difference was found only for BST Information. Finally, a principal component analysis shows that temporal sequencing and BST Information loaded on a common factor, separately from the language measures. It is concluded that language level is an important correlate of narrative performance more generally in this diagnostically heterogeneous sample, and that nonverbal temporal sequencing functions are important especially for conveying story information. Theoretical and clinical implications are discussed.
C1 [Johnels, Jakob Asberg; Hagberg, Bibbi; Gillberg, Christopher; Miniscalco, Carmela] Univ Gothenburg, Inst Neurosci & Physiol, Gillberg Neuropsychiat Ctr, SE-41119 Gothenburg, Sweden.
[Johnels, Jakob Asberg] Univ Gothenburg, Dept Psychol, SE-41119 Gothenburg, Sweden.
[Miniscalco, Carmela] Univ Gothenburg, Inst Neurosci & Physiol, Div Speech & Language Pathol, SE-41119 Gothenburg, Sweden.
RP Johnels, JA (reprint author), Univ Gothenburg, Inst Neurosci & Physiol, Gillberg Neuropsychiat Ctr, Kungsgatan 12, SE-41119 Gothenburg, Sweden.
EM psyjaas@psy.gu.se
CR Abelson R., 1977, SCRIPTS PLANS GOALS
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White S, 2006, COGN NEUROPSYCHOL, V23, P748, DOI 10.1080/02643290500438607
NR 46
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0036-5564
J9 SCAND J PSYCHOL
JI Scand. J. Psychol.
PD OCT
PY 2013
VL 54
IS 5
BP 376
EP 385
DI 10.1111/sjop.12067
PG 10
WC Psychology, Multidisciplinary
SC Psychology
GA 211RN
UT WOS:000323927800005
PM 23855443
ER
PT J
AU Lange, N
McDougle, CJ
AF Lange, Nicholas
McDougle, Christopher J.
TI Help for the Child with Autism
SO SCIENTIFIC AMERICAN
LA English
DT Article
CR Centers for Disease Control and Prevention, LEARN SIGNS ACT EARL
Dawson G, 2012, J AM ACAD CHILD PSY, V51, P1150, DOI 10.1016/j.jaac.2012.08.018
NR 2
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0036-8733
J9 SCI AM
JI Sci.Am.
PD OCT
PY 2013
VL 309
IS 4
BP 72
EP 77
DI 10.1038/scientificamerican1013-72
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 220JA
UT WOS:000324577900032
PM 24137859
ER
PT J
AU Johnson, CR
Turner, KS
Foldes, E
Brooks, MM
Kronk, R
Wiggs, L
AF Johnson, Cynthia R.
Turner, Kylan S.
Foldes, Emily
Brooks, Maria M.
Kronk, Rebecca
Wiggs, Luci
TI Behavioral parent training to address sleep disturbances in young
children with autism spectrum disorder: a pilot trial
SO SLEEP MEDICINE
LA English
DT Article
DE Sleep; Sleep disturbances; Sleep problems; Bedtime problems; Autism;
Autism spectrum disorders; Parent training
ID PERVASIVE DEVELOPMENTAL DISORDERS; SEVERE LEARNING-DISABILITIES;
CHALLENGING DAYTIME BEHAVIOR; CONTROLLED-RELEASE MELATONIN; RANDOMIZED
CONTROLLED-TRIAL; SCHOOL-AGE-CHILDREN; INFANT SLEEP; PSYCHOSOCIAL
INTERVENTIONS; PATTERNS; BEDTIME
AB Objectives: A large percentage of children with autism spectrum disorders (ASD) have bedtime and sleep disturbances. However, the treatment of these disturbances has been understudied. The purpose of our study was to develop a manualized behavioral parent training (BPT) program for parents of young children with ASD and sleep disturbances and to test the feasibility, fidelity, and initial efficacy of the treatment in a small randomized controlled trial (RCT).
Participants and methods: Parents of a sample of 40 young children diagnosed with ASD with an average age of 3.5 years were enrolled in our study. Participants were randomized to either the BPT program group or a comparison group who were given nonsleep-related parent education. Each participant was individually administered a 5-session program delivered over the 8-week study. Outcome measures of feasibility, fidelity, and efficacy were collected at weeks 4 and 8 after the baseline time point. Children's sleep was assessed by parent report and objectively by actigraphy.
Results: Of the 20 participants in each group, data were available for 15 participants randomized to BPT and 18 participants randomized to the comparison condition. Results supported the feasibility of the manualized parent training program and the comparison program. Treatment fidelity was high for both groups. The BPT program group significantly improved more than the comparison group based on the primary sleep outcome of parent report. There were no objective changes in sleep detected by actigraphy.
Conclusions: Our study is one of few RCTs of a BPT program to specifically target sleep disturbances in a well-characterized sample of young children with ASD and to demonstrate the feasibility of the approach. Initial efficacy favored the BPT program over the comparison group and suggested that this manualized parent training approach is worthy of further examination of the efficacy within a larger RCT. (C) 2013 Elsevier B. V. All rights reserved.
C1 [Johnson, Cynthia R.; Turner, Kylan S.; Foldes, Emily] Univ Pittsburgh, Sch Med, Autism Ctr, Pittsburgh, PA 15213 USA.
[Brooks, Maria M.] Univ Pittsburgh, Sch Publ Hlth, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA.
[Kronk, Rebecca] Duquesne Univ, Sch Nursing, Pittsburgh, PA 15282 USA.
[Wiggs, Luci] Oxford Brookes Univ, Oxford OX3 0BP, England.
RP Johnson, CR (reprint author), Univ Pittsburgh, Sch Med, Childrens Hosp Pittsburgh, Autism Ctr, 3420 5th Ave, Pittsburgh, PA 15213 USA.
EM Cynthia.Johnson@chp.edu
FU National Institute of Mental Health [R34 MH082882-01A2]; Pennsylvania
Bureau of Autism Services, Department of Public Welfare; National
Institute for Research Resources [UL1 RR024153-06, ULTR000005]
FX Our study was supported by funding from the National Institute of Mental
Health (R34 MH082882-01A2) award to the first author, Autism Speaks,
Autism Service, Education, Research and Training grant from the
Pennsylvania Bureau of Autism Services, Department of Public Welfare,
and National Institute for Research Resources (UL1 RR024153-06 &
ULTR000005).
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NR 71
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
J9 SLEEP MED
JI Sleep Med.
PD OCT
PY 2013
VL 14
IS 10
BP 995
EP 1004
DI 10.1016/j.sleep.2013.05.013
PG 10
WC Clinical Neurology
SC Neurosciences & Neurology
GA 214AY
UT WOS:000324103600012
PM 23993773
ER
PT J
AU Wang, HT
Casillas, N
AF Wang, Hui-Ting
Casillas, Nicole
TI Asian American Parents' Experiences of Raising Children with Autism:
Multicultural Family Perspective
SO JOURNAL OF ASIAN AND AFRICAN STUDIES
LA English
DT Article
DE Asian immigrants; autism; cultural linguistic diversity; parents
AB This article describes the experiences of Mandarin-speaking immigrant parents - an understudied population - raising a child with autism in the United States. Using purposive sampling, semi-structured interviews were conducted with four sets of parents and two mothers of children with autism. The interviews were transcribed and translated verbatim and analyzed using content analysis. Three main themes regarding parents' experiences were derived from the data: immigration and cultural accommodation; impact of autism and cognitive response; and outlook for the future. Implications for developing cultural competency to serve culturally and linguistically diverse populations were discussed. It is suggested that more cultural studies involving participants of diverse backgrounds should be conducted in further studies.
C1 [Wang, Hui-Ting] Natl Taiwan Normal Univ, Dept Special Educ, Taipei 106, Taiwan.
[Casillas, Nicole] Univ Nevada, Reno, NV 89557 USA.
RP Wang, HT (reprint author), Natl Taiwan Normal Univ, Dept Special Educ, 162,Sec 1,HePing East Rd, Taipei 106, Taiwan.
EM tinaw@ntnu.edu.tw
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NR 32
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0021-9096
EI 1745-2538
J9 J ASIAN AFR STUD
JI J. Asian Afr. Stud.
PD OCT
PY 2013
VL 48
IS 5
BP 594
EP 606
DI 10.1177/0021909612467421
PG 13
WC Area Studies
SC Area Studies
GA V38ZA
UT WOS:000209380100004
ER
PT J
AU Deal, LS
Britt, D
DeMuro, C
AF Deal, Linda S.
Britt, Dana
DeMuro, Carla
TI Development of a clinical outcome assessment for autism spectrum
disorder
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Deal, Linda S.] Shire, Wayne, PA USA.
[Britt, Dana; DeMuro, Carla] RTI Hlth Solut, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2013
VL 22
SU 1
MA 104.2
PG 1
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA V38QX
UT WOS:000209359000045
ER
PT J
AU Payakachat, N
Tilford, JM
Kuhlthau, KA
Kovacs, E
Bellando, J
Pyne, JM
AF Payakachat, Nalin
Tilford, J. Mick
Kuhlthau, Karen A.
Kovacs, Erica
Bellando, Jayne
Pyne, Jeffrey M.
TI Predicting health utilities for children with autism spectrum disorders
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Payakachat, Nalin; Tilford, J. Mick; Bellando, Jayne; Pyne, Jeffrey M.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA.
[Kuhlthau, Karen A.] Ctr Child & Adolescent Hlth Policy, Boston, MA USA.
[Kovacs, Erica] Columbia Univ, Med Ctr, Div Child & Adolescent Psychiat, New York, NY 10027 USA.
NR 0
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2013
VL 22
SU 1
MA 1035
PG 2
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA V38QX
UT WOS:000209359000176
ER
PT J
AU Payakachat, N
Tilford, JM
Kovacs, E
Delahaye, J
Kuhlthau, KA
AF Payakachat, Nalin
Tilford, J. Mick
Kovacs, Erica
Delahaye, Jennifer
Kuhlthau, Karen A.
TI Relationship between Child Health-related Quality of Life and SF6D
scores for children with autism and their caregivers
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Payakachat, Nalin; Tilford, J. Mick] Univ Arkansas Med Sci, Little Rock, AR 72205 USA.
[Kovacs, Erica] Columbia Univ, Med Ctr, Div Child & Adolescent Psychiat, New York, NY 10027 USA.
[Delahaye, Jennifer] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Kuhlthau, Karen A.] Ctr Child & Adolescent Hlth Policy, Boston, MA USA.
NR 0
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2013
VL 22
SU 1
MA 210.3
PG 1
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA V38QX
UT WOS:000209359000095
ER
PT J
AU Tilford, JM
Payakachat, N
Pyne, JM
Kovacs, E
Kuhlthau, KA
Brouwer, W
AF Tilford, J. Mick
Payakachat, Nalin
Pyne, Jeffrey M.
Kovacs, Erica
Kuhlthau, Karen A.
Brouwer, Werner
TI Health utilities and caregiver spillover effects associated with sleep
problems in children with autism spectrum disorders
SO QUALITY OF LIFE RESEARCH
LA English
DT Meeting Abstract
C1 [Tilford, J. Mick; Payakachat, Nalin; Pyne, Jeffrey M.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA.
[Kovacs, Erica] Columbia Univ, Med Ctr, Div Child & Adolescent Psychiat, New York, NY 10027 USA.
[Kuhlthau, Karen A.] Ctr Child & Adolescent Hlth Policy, Boston, MA USA.
[Brouwer, Werner] Erasmus Univ Rottedam, Rotterdam, Netherlands.
NR 0
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2013
VL 22
SU 1
MA 206.5
PG 2
WC Health Care Sciences & Services; Health Policy & Services; Public,
Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA V38QX
UT WOS:000209359000078
ER
PT J
AU Hanaie, R
Mohri, I
Kagitani-Shimono, K
Tachibana, M
Azuma, J
Matsuzaki, J
Watanabe, Y
Fujita, N
Taniike, M
AF Hanaie, Ryuzo
Mohri, Ikuko
Kagitani-Shimono, Kuriko
Tachibana, Masaya
Azuma, Junji
Matsuzaki, Junko
Watanabe, Yoshiyuki
Fujita, Norihiko
Taniike, Masako
TI Altered Microstructural Connectivity of the Superior Cerebellar Peduncle
is Related to Motor Dysfunction in Children with Autistic Spectrum
Disorders
SO CEREBELLUM
LA English
DT Article
DE Diffusion tensor imaging; Tractography; Volumetry; Cerebellum; Autistic
spectrum disorders; Motor
ID HIGH-FUNCTIONING AUTISM; MESSENGER-RNA LEVELS; WHITE-MATTER;
INFANTILE-AUTISM; ASPERGERS-DISORDER; AXONAL INJURY; OPTIC-NERVE;
SPINAL-CORD; DIFFUSION; BRAIN
AB Many studies have reported motor impairments in autistic spectrum disorders (ASD). However, the brain mechanism underlying motor impairment in ASD remains unclear. Recent neuroimaging studies have suggested that underconnectivity between the cerebellum and other brain regions contributes to the features of ASD. In this study, we investigated the microstructural integrity of the cerebellar pathways, including the superior, middle, and inferior cerebellar peduncles, of children with and without ASD by using diffusion tensor imaging (DTI) tractography to determine whether the microstructural integrity of the cerebellar pathways is related to motor function in children with ASD. Thirteen children with ASD and 11 age-, gender-, handedness-, and IQ-matched typically developing (TD) controls were enrolled in this study. DTI outcome measurements, such as fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD), for the cerebellar pathways were calculated. The Movement Assessment Battery for Children 2 (M-ABC 2) was used for assessing motor functions. There were no significant differences between the two groups in RD. However, compared to the TD subjects, patients with ASD had a significantly lower FA in the right superior cerebellar peduncle and lower AD in the left superior cerebellar peduncle, in addition to a significantly lower score in ball skills and the total test score of M-ABC 2. There was a significant positive correlation between the total test score of M-ABC 2 and FA in the right superior cerebellar peduncle in the ASD group. These findings suggest that the altered microstructural integrity of the superior cerebellar peduncle may be related to motor impairment in ASD.
C1 [Hanaie, Ryuzo; Mohri, Ikuko; Kagitani-Shimono, Kuriko; Taniike, Masako] Osaka Univ, Grad Sch Med, United Grad Sch Child Dev, Suita, Osaka 5650871, Japan.
[Mohri, Ikuko; Tachibana, Masaya; Matsuzaki, Junko; Taniike, Masako] Osaka Univ, Mol Res Ctr Childrens Mental Dev, United Grad Sch Child Dev, Suita, Osaka 5650871, Japan.
[Mohri, Ikuko; Kagitani-Shimono, Kuriko; Tachibana, Masaya; Azuma, Junji; Taniike, Masako] Osaka Univ, Grad Sch Med, Dept Pediat, Suita, Osaka 5650871, Japan.
[Watanabe, Yoshiyuki; Fujita, Norihiko] Osaka Univ, Grad Sch Med, Dept Diagnost & Intervent Radiol, Suita, Osaka 5650871, Japan.
RP Taniike, M (reprint author), Osaka Univ, Grad Sch Med, United Grad Sch Child Dev, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM masako@kokoro.med.osaka-u.ac.jp
FU Special Coordination Funds for Promoting Science and Technology from
Ministry of Education, Culture, Sports, Science and Technology of Japan;
Osaka University
FX This work was supported in part by Special Coordination Funds for
Promoting Science and Technology from the Ministry of Education,
Culture, Sports, Science and Technology of Japan, and the Osaka
University Program for the Support of Networking among Present and
Future Women Researchers. We thank Mayumi Wada for helping with our
volumetric analysis and are grateful to all the children and parents who
participated in this study.
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NR 86
TC 3
Z9 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1473-4222
J9 CEREBELLUM
JI Cerebellum
PD OCT
PY 2013
VL 12
IS 5
BP 645
EP 656
DI 10.1007/s12311-013-0475-x
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 210PB
UT WOS:000323845100006
PM 23564050
ER
PT J
AU Riva, D
Annunziata, S
Contarino, V
Erbetta, A
Aquino, D
Bulgheroni, S
AF Riva, Daria
Annunziata, Silvia
Contarino, Valeria
Erbetta, Alessandra
Aquino, Domenico
Bulgheroni, Sara
TI Gray Matter Reduction in the Vermis and CRUS-II Is Associated with
Social and Interaction Deficits in Low-Functioning Children with
Autistic Spectrum Disorders: a VBM-DARTEL Study
SO CEREBELLUM
LA English
DT Article
DE Autism spectrum disorders; ADI; ADOS; Vermis; Crus II; DARTEL VBM
ID VOXEL-BASED MORPHOMETRY; PERVASIVE DEVELOPMENTAL DISORDERS;
COGNITIVE-AFFECTIVE SYNDROME; MIRROR-NEURON SYSTEM; CEREBELLAR
CONTRIBUTION; ASPERGERS-SYNDROME; BRAIN STRUCTURE; WHITE-MATTER; MRI;
CONNECTIVITY
AB Voxel-based morphometry (VBM) studies have reported abnormalities in brain regions involved in functions that are commonly impaired in autism spectrum disorders (ASD). However, little is known about brain structure anomalies in low-functioning (LF) young children with ASD. A VBM analysis was carried out to assess brain regions involved in ASD LF children, and a multiple regression analysis was used to examine the relationship between regional volume changes and autism symptom measures. Twenty-six LF ASD children (2-10 years) were compared with 21 controls. A VBM-Diffeomorphic Anatomical Registration analysis using Exponentiated Lie algebra (DARTEL) was used to evaluate gray matter (GM) and white matter alterations, covaried with Intelligence Quotient, age, and total brain volume. The resulting altered regions were correlated with Autism Diagnostic Interview (ADI)-Revised and Autism Diagnostic Observation Schedule (ADOS)-Generic scores. GM bilateral reduction was noted in the cerebellum (Crus II and vermis) and in the hippocampi in ASD group. GM reduction was also detected in the inferior and superior frontal gyri, in the occipital medial and superior gyri, and in the inferior temporal gyrus of the left cerebral hemisphere. In the right hemisphere, GM reduction was found in the post-central cortex and in the occipital inferior gyrus. Multiple regression analysis showed a correlation between alterations in GM volume in the cerebellum (Crus II and vermis) and ADI-communication and ADOS-total (communication and interaction) scores. These findings seem to confirm that the cerebellum is involved in integrating and regulating emotional and cognitive functions which are impaired in ASD.
C1 [Riva, Daria; Annunziata, Silvia; Bulgheroni, Sara] Fdn IRCCS Ist Neurol C Besta, Dev Neurol Div, I-20133 Milan, Italy.
[Contarino, Valeria; Erbetta, Alessandra; Aquino, Domenico] Fdn IRCCS Ist Neurol C Besta, Dept Neuroradiol, I-20133 Milan, Italy.
RP Riva, D (reprint author), Fdn IRCCS Ist Neurol C Besta, Dev Neurol Div, Via Celoria 11, I-20133 Milan, Italy.
EM driva@istituto-besta.it
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NR 81
TC 4
Z9 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1473-4222
J9 CEREBELLUM
JI Cerebellum
PD OCT
PY 2013
VL 12
IS 5
BP 676
EP 685
DI 10.1007/s12311-013-0469-8
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 210PB
UT WOS:000323845100009
PM 23572290
ER
PT J
AU Ziats, MN
Rennert, OM
AF Ziats, Mark N.
Rennert, Owen M.
TI The Cerebellum in Autism: Pathogenic or an Anatomical Beacon?
SO CEREBELLUM
LA English
DT Letter
ID HUMAN BRAIN; TRANSCRIPTOME; EXPRESSION
C1 [Ziats, Mark N.; Rennert, Owen M.] NICHHD, Lab Clin & Dev Genom, NIH, Bethesda, MD 20814 USA.
[Ziats, Mark N.] Baylor Coll Med MSTP, Houston, TX USA.
[Ziats, Mark N.] NIH Univ Cambridge Biomed Scholars Program, Cambridge, England.
RP Ziats, MN (reprint author), NICHHD, Lab Clin & Dev Genom, NIH, 49 Convent Dr,Bldg 49,Room 2C08, Bethesda, MD 20814 USA.
EM ziatsm@mail.nih.gov; rennerto@mail.nih.gov
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NR 17
TC 3
Z9 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1473-4222
J9 CEREBELLUM
JI Cerebellum
PD OCT
PY 2013
VL 12
IS 5
BP 776
EP 777
DI 10.1007/s12311-013-0483-x
PG 2
WC Neurosciences
SC Neurosciences & Neurology
GA 210PB
UT WOS:000323845100018
PM 23605119
ER
PT J
AU Fatemi, SH
AF Fatemi, S. Hossein
TI Cerebellum and Autism
SO CEREBELLUM
LA English
DT Letter
ID DYSFUNCTION; COGNITION
C1 [Fatemi, S. Hossein] Univ Minnesota, Sch Med, Div Neurosci Res, Dept Psychiat, Minneapolis, MN 55455 USA.
[Fatemi, S. Hossein] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA.
[Fatemi, S. Hossein] Univ Minnesota, Sch Med, Dept Neurosci, Minneapolis, MN 55455 USA.
RP Fatemi, SH (reprint author), Univ Minnesota, Sch Med, Div Neurosci Res, Dept Psychiat, 420 Delaware St SE,MMC 392, Minneapolis, MN 55455 USA.
EM fatem002@umn.edu
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Ziats MN, 2013, CEREBELLUM IN PRESS
NR 7
TC 2
Z9 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1473-4222
J9 CEREBELLUM
JI Cerebellum
PD OCT
PY 2013
VL 12
IS 5
BP 778
EP 779
DI 10.1007/s12311-013-0484-9
PG 2
WC Neurosciences
SC Neurosciences & Neurology
GA 210PB
UT WOS:000323845100019
PM 23605188
ER
PT J
AU Luiselli, JK
Woods, KE
Keary, P
Parenteau, RE
AF Luiselli, James K.
Woods, Kathryn E.
Keary, Patrick
Parenteau, Rebecca E.
TI Practitioner Attitudes and Beliefs about Exercise, Athletic, and
Recreational Activities for Children and Youth with Intellectual and
Developmental Disabilities
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Exercise; Athletics; Recreation; Social validity assessment;
Intellectual and developmental disabilities
ID MENTAL-RETARDATION; PHYSICAL-ACTIVITY; SPECIAL-OLYMPICS; AEROBIC
EXERCISE; ADULTS; AUTISM; INDIVIDUALS; PERFORMANCE; BEHAVIORS; FITNESS
AB We describe construction of a social validity assessment questionnaire that was distributed to practitioners at a specialized school to solicit their attitudes and beliefs about exercise, athletic, and recreational activities for children and youth with intellectual and developmental disabilities. The questionnaire data identified the types of activities available at the school and associated benefits, negative outcomes, and impediments to participation. As well, the questionnaire asked the practitioners to identify prerequisite skills for engaging in the activities. We discuss implications of these findings and present recommendations for future research.
C1 [Luiselli, James K.; Woods, Kathryn E.; Keary, Patrick; Parenteau, Rebecca E.] May Inst, Randolph, MA USA.
RP Luiselli, JK (reprint author), May Inst, Randolph, MA USA.
EM jluiselli@mayinstitute.org
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NR 24
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD OCT
PY 2013
VL 25
IS 5
BP 485
EP 492
DI 10.1007/s10882-012-9323-z
PG 8
WC Rehabilitation
SC Rehabilitation
GA 211CS
UT WOS:000323882400001
ER
PT J
AU Moore, DW
Anderson, A
Treccase, F
Deppeler, J
Furlonger, B
Didden, R
AF Moore, Dennis W.
Anderson, Angelika
Treccase, Francesca
Deppeler, Joanne
Furlonger, Brett
Didden, Robert
TI A Video-Based Package to Teach a Child with Autism Spectrum Disorder to
Write Her Name
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Autism; Backward chaining; Point-of-view video modeling; Reinforcement;
Writing
ID DEVELOPMENTAL-DISABILITIES; PERSPECTIVE-TAKING; SKILLS; COMMUNICATION
AB The purpose of this study was to trial a procedure involving point-of-view video modeling, backward chaining and reinforcement to teach a child with ASD to write her name. Video modeling and reinforcement were used to teach letter writing, and backward chaining to produce the complete name. A multiple baseline across behaviors design treating each letter as a different behavior established the effectiveness of the procedure for teaching letter writing and generalization data suggest the efficacy of backward chaining in teaching production of her name. Treatment integrity was satisfactory and a post-intervention questionnaire indicated the intervention was acceptable to the participant's mother. These findings suggest that point-of-view video modeling in combination with backward chaining and reinforcement may be an effective tool for teaching new academic skills.
C1 [Moore, Dennis W.; Anderson, Angelika; Treccase, Francesca; Deppeler, Joanne; Furlonger, Brett] Monash Univ, Fac Educ, Melbourne, Vic 3800, Australia.
[Didden, Robert] Radboud Univ Nijmegen, NL-6525 ED Nijmegen, Netherlands.
[Treccase, Francesca] Deakin Univ, Fac Hlth Med Nursing & Behav Sci, Geelong, Vic 3217, Australia.
RP Moore, DW (reprint author), Monash Univ, Fac Educ, Melbourne, Vic 3800, Australia.
EM dennis.moore@monash.edu
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NR 28
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD OCT
PY 2013
VL 25
IS 5
BP 493
EP 503
DI 10.1007/s10882-012-9325-x
PG 11
WC Rehabilitation
SC Rehabilitation
GA 211CS
UT WOS:000323882400002
ER
PT J
AU Rojahn, J
Barnard-Brak, L
Richman, D
Dotson, W
Medeiros, K
Wei, TL
Abby, L
AF Rojahn, Johannes
Barnard-Brak, Lucy
Richman, David
Dotson, Wesley
Medeiros, Kristen
Wei, Tianlan
Abby, Layla
TI Behavior Problems in Individuals with Cornelia de Lange Syndrome:
Population-Specific Validation of the Behavior Problem Inventory-01
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Cornelia de Lange Syndrome; Intellectual disabilities; Self-injurious
behavior; Stereotyped behavior; Aggressive/destructive behavior
ID SELF-INJURIOUS-BEHAVIOR; INTELLECTUAL DISABILITIES; REPETITIVE
BEHAVIORS; DELANGE-SYNDROME; SHORT FORM; RELIABILITY; VALIDITY;
PHENOMENOLOGY; PREVALENCE; SCALE
AB The purpose of this study was to validate the Behavior Problem Inventory-01 (BPI-01; Rojahn J Autism Dev Disord 31:577-588, 2001) in a population of 179 individuals with Cornelia de Lange Syndrome (CdLS) and to extend the literature on the behavioral phenotype of individuals with CdLS. We also set out to determine the relationship between the frequency of self-injurious behavior (SIB), stereotyped behavior, and aggressive/destructive behavior topographies with the level of intellectual disability (ID). The BPI-01 among the individuals with CdLS showed a sufficient factor structure and internal consistency of each of the three assessed construct (SIB, stereotyped behavior, and aggressive/destructive behaviors). Similar to the findings in other populations with intellectual disabilities, those with severe/profound intellectual impairment exhibited significantly more frequent SIB and stereotypic behavior than those with moderate or mild intellectual impairment or average intellectual abilities while no statistically a differences were noted for aggressive behavior across levels of intellectual impairment. There is a need for uniformity of assessment tools across different study to improve our ability to compare results across different prevalence studies.
C1 [Rojahn, Johannes; Medeiros, Kristen] George Mason Univ, Fairfax, VA 22030 USA.
[Barnard-Brak, Lucy; Richman, David; Dotson, Wesley; Wei, Tianlan; Abby, Layla] Texas Tech Univ, Lubbock, TX 79409 USA.
[Rojahn, Johannes] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA.
RP Rojahn, J (reprint author), George Mason Univ, Dept Psychol, 10340 Democracy Lane,Suite 202, Fairfax, VA 22030 USA.
EM jrojahn@gmu.edu
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NR 28
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD OCT
PY 2013
VL 25
IS 5
BP 505
EP 515
DI 10.1007/s10882-012-9329-6
PG 11
WC Rehabilitation
SC Rehabilitation
GA 211CS
UT WOS:000323882400003
ER
PT J
AU Rieske, RD
Matson, JL
Davis, TE
AF Rieske, Robert D.
Matson, Johnny L.
Davis, Thompson E., III
TI The Moderating Effect of Autism Symptomatology on Anxiety Symptoms
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorders; Anxiety; Infants; Children; Moderation
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; INTELLECTUAL
DISABILITIES; DIFFERENTIAL-DIAGNOSIS; MODIFIED CHECKLIST; SOCIAL-SKILLS;
CHILDREN; TODDLERS; INFANTS; PSYCHOPATHOLOGY
AB Anxiety disorders are prevalent in the general population and the prevalence of anxiety disorders for people with Autism Spectrum Disorders (ASD) is even higher. Researchers have shown how cognitive and adaptive functioning are related and affect anxiety symptoms in children as well as the high comorbidity with ASD. The aim of this study was to confirm those relationships and to examine the moderating effect of autism symptomatology in infants and toddlers. A sample of 2,366 infants and toddlers between the ages of 17 and 36 months of age was examined using a hierarchical moderation analysis. Post-hoc analyses were then completed to determine the source of any interaction. The relationship between autism symptomatology and anxiety was confirmed as was the relationship between Cognitive Developmental Quotient (DQ) and anxiety; adaptive DQ was found to be positively correlated with anxiety. The moderating effect of autism symptomatology between DQs individually and anxiety was statistically significant but with a small effect size. Autism symptomatology also moderated the relationship between Cognitive and Adaptive DQ with anxiety but with a negligible effect size.
C1 [Rieske, Robert D.; Matson, Johnny L.; Davis, Thompson E., III] Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
RP Rieske, RD (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM rrieske@hotmail.com
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NR 63
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD OCT
PY 2013
VL 25
IS 5
BP 517
EP 531
DI 10.1007/s10882-012-9330-0
PG 15
WC Rehabilitation
SC Rehabilitation
GA 211CS
UT WOS:000323882400004
ER
PT J
AU Bitsika, V
Sharpley, CF
Bell, R
AF Bitsika, Vicki
Sharpley, Christopher F.
Bell, Ryan
TI The Buffering Effect of Resilience upon Stress, Anxiety and Depression
in Parents of a Child with an Autism Spectrum Disorder
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Stress; Anxiety; Depression; Resilience; Parents; ASD
ID PSYCHOLOGICAL RESILIENCE; SYMPTOM SEVERITY; FAMILY STRESS;
INTERVENTIONS; MOTHERS; RESOURCES; HEALTH; IMPACT; SCALE; ASD
AB The possible buffering effects of psychological resilience on stress, anxiety and depression associated with parenting a child with an Autism Spectrum Disorder (ASD) were investigated in 73 mothers and 35 fathers who had at least one child with an ASD and who completed a questionnaire about their experiences as parents. Mothers were significantly more anxious and depressed than fathers, and reported being "stretched beyond their resources" more frequently than fathers. Both mothers and fathers reported clinically significant anxiety and depression between three and five times the rate reported in the normal adult population. Moderation analysis showed that psychological resilience acted as a buffer against the development of elevated anxiety and depression associated with high levels of daily stress from parenting. Further, although the daily stress of parenting a child with an ASD was associated with quite severe anxiety and depression, even relatively low levels of resilience buffered against this anxiety and depression. Suggestions are made for assisting parents to develop psychological resilience in dealing with the stress associated with parenting their child with an ASD.
C1 [Bitsika, Vicki] Bond Univ, Ctr Autism Spectrum Disorders, Gold Coast, Qld, Australia.
[Sharpley, Christopher F.] Univ New England, Brain Behav Res Grp, Armidale, NSW, Australia.
[Bell, Ryan] Bond Univ, Gold Coast, Qld, Australia.
RP Sharpley, CF (reprint author), POB 378, Coolangatta, Qld 4225, Australia.
EM csharpley@onthenet.com.au
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NR 45
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD OCT
PY 2013
VL 25
IS 5
BP 533
EP 543
DI 10.1007/s10882-013-9333-5
PG 11
WC Rehabilitation
SC Rehabilitation
GA 211CS
UT WOS:000323882400005
ER
PT J
AU Solomon, O
Lawlor, MC
AF Solomon, Olga
Lawlor, Mary C.
TI "And I look down and he is gone": Narrating autism, elopement and
wandering in Los Angeles
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE USA; African American; Autism; Elopement; Family perspectives; Mothers;
Narrative; Wandering
ID SPECTRUM DISORDER; HEALTH-CARE; CHILDREN; DISPARITIES; DIAGNOSIS;
EXPERIENCES; SERVICES; ACCESS
AB 'Wandering' and 'elopement' have been identified as common in autism, affecting half of all diagnosed children ages four to ten, yet families rarely receive advice from practitioners even after the fact. Family perspectives have been missing from the literature as well as from public health and policy debates on how and when to respond to this problem. The problem of 'wandering' and 'elopement' reveals a complex intersection of larger issues encountered by families of children with autism. To consider these issues, this article examines 'wandering' and 'elopement' from the perspectives of African American mothers of children with autism, an underrepresented group in autism research. We consider how the mothers experience these behaviors and the response to these behaviors by professionals, such as service coordinators and law enforcement personnel working within various jurisdictions that become involved with the problem. We analyze the mothers' narratives about 'wandering' and 'elopement' drawn from ethnographic interviews that were collected between October 1, 2009 and August 31, 2012. These interviews were part of a larger project on disparities in autism diagnosis and services that followed a cohort of 25 four to ten-year old children. Drawing on narrative, phenomenological and interpretive traditions, we trace the mothers' developing understandings of 'wandering' and 'elopement' over time, and show how these understandings become elaborated and transformed. This article provides a nuanced, moment-to-moment and longitudinal picture of the mothers' experiences of 'wandering' and 'elopement' that enriches the cross-sectional view of large-scale surveys about the problem and contributes unique insights at the family and community levels. Implications for professional awareness, clinical practice and service provision are also suggested. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Solomon, Olga; Lawlor, Mary C.] Univ So Calif, Los Angeles, CA 90089 USA.
RP Solomon, O (reprint author), Univ So Calif, Los Angeles, CA 90089 USA.
EM olga.solomon@usc.edu; lawlor@usc.edu
FU Autism in Urban Context: Linking Heterogeneity with Health and Service
Disparities (NIH/NIMH) [R01 MH089474]; Division of Occupational Science
and Occupational Therapy at the Herman Ostrow School of Dentistry at the
University of Southern California
FX We thank the families who participated in this research and hope that
this article "makes good" on the stories and experiences that they
shared with us. We thank our collaborators: Sharon Cermak, EdD, Marie
Poulsen, PhD, Thomas Valente, PhD, Marian Williams, PhD, and Larry Yin,
MD, MSPH; our consultant, Marshalyn Yeargin-Allsopp, MD; our
post-doctoral research associates Tessa Milman, OTD, OTR/L, Kimberly
Wilkinson, PhD, OTR/L; and our doctoral research assistant Amber Angell,
MA, OTR/L. We are also grateful to four anonymous reviewers for their
comments and suggestions. This study was supported by a grant 'Autism in
Urban Context: Linking Heterogeneity with Health and Service
Disparities' (NIH/NIMH, R01 MH089474, 2009-2012, O. Solomon, P.I.). The
content of this article is solely the responsibility of the authors and
does not necessarily represent the official views of the National
Institute of Mental Health or the National Institutes of Health. The
authors gratefully acknowledge the support of the Division of
Occupational Science and Occupational Therapy at the Herman Ostrow
School of Dentistry at the University of Southern California.
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NR 75
TC 4
Z9 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD OCT
PY 2013
VL 94
BP 106
EP 114
DI 10.1016/j.socscimed.2013.06.034
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 210DK
UT WOS:000323809300014
PM 23890970
ER
PT J
AU Zurawicz, E
Kaluzna-Czaplinska, J
Rynkowski, J
AF Zurawicz, Ewa
Kaluzna-Czaplinska, Joanna
Rynkowski, Jacek
TI Chromatographic methods in the study of autism
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE autism; chromatography; HPLC; GC-MS; biomarker
ID SPECTRUM DISORDERS; OPIOID-PEPTIDES; CHILDREN; ACID; SEROTONIN;
ETIOLOGY; FEATURES
AB Research into biomarkers of autism is a new means of medical intervention in this disease. Chromatographic techniques, especially coupled with mass spectrometry, are widely used in determination of biomarkers and assessment of effectiveness of autism therapy owing to their sensitivity and selectivity. Among the chromatographic techniques gas chromatography and liquid chromatography, especially high-performance liquid chromatography, have found application in clinical trials. The high-performance liquid chromatography technique allows an analysis of liquid samples with a wide range of molecules, small and large, providing an opportunity to perform advanced assays within a short time frame. Gas chromatography with the appropriate preparation of samples (gaseous and liquid) and a selection of analysis conditions enables the separation of thermally stable, volatile and non-volatile organic substances in short runtimes. The chromatographic techniques that are currently used in metabolic studies in autism are designed to identify abnormalities in three areas: the metabolism of neurotransmitters, nutritional and metabolic status and manifestations of oxidative stress. This review presents a necessary theoretical introduction and examples of applications of chromatographic studies of disorder markers in autism. Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Zurawicz, Ewa; Kaluzna-Czaplinska, Joanna; Rynkowski, Jacek] Lodz Univ Technol, Inst Gen & Ecol Chem, Dept Chem, PL-90924 Lodz, Poland.
RP Kaluzna-Czaplinska, J (reprint author), Lodz Univ Technol, Inst Gen & Ecol Chem, Dept Chem, Zeromskiego 116, PL-90924 Lodz, Poland.
EM jkaluzna@p.lodz.pl
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NR 49
TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD OCT
PY 2013
VL 27
IS 10
SI SI
BP 1273
EP 1279
DI 10.1002/bmc.2911
PG 7
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Chemistry, Analytical; Pharmacology & Pharmacy
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA 211IR
UT WOS:000323900600005
PM 23605782
ER
PT J
AU Liu, X
Zhou, XB
Lackaff, J
AF Liu, Xin
Zhou, Xiaobin
Lackaff, Julie
TI Incremental Validity in the Clinical Assessment of Early Childhood
Development
SO JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
LA English
DT Article
DE incremental validity; childhood; assessment; rating scales; autism;
developmental delay
ID MULTIPLE INFORMANTS; CHILDREN; PRESCHOOL; VALIDATION; BEHAVIORS;
DISORDER; DELAY
AB The authors demonstrate the increment of clinical validity in early childhood assessment of physical impairment (PI), developmental delay (DD), and autism (AUT) using multiple standardized developmental screening measures such as performance measures and parent and teacher rating scales. Hierarchical regression and sensitivity/specificity analyses were used to identify the differential impact of each domain the scales measure. Significant findings include (a) self-help domains in either parent or teacher questionnaires are more significant contributors than social-emotional domains to early detection, (b) performance measures are stronger predictors than parent or teacher questionnaires in detecting physical impairment or developmental delay, and (c) parent questionnaires measuring self-help skills are a stronger predictor of autism than performance measures. These results support the combined use of parent and teacher rating scales and provide important implications in choosing instruments for different developmental disorders when time and resources are limited.
C1 [Liu, Xin] Pearson, Bloomington, MN USA.
[Zhou, Xiaobin] Pearson, San Antonio, TX USA.
[Lackaff, Julie] Pearson, Chicago, IL 60657 USA.
[Liu, Xin] Data Recognit Corp, Maple Grove, MN USA.
RP Lackaff, J (reprint author), Pearson, Clin Content Dev Assessment & Informat, 3180 N Lake Shore Dr,15A, Chicago, IL 60657 USA.
EM julie.lackaff@pearson.com
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NR 38
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0734-2829
J9 J PSYCHOEDUC ASSESS
JI J. Psychoeduc. Assess.
PD OCT
PY 2013
VL 31
IS 5
BP 506
EP 515
DI 10.1177/0734282912473457
PG 10
WC Psychology, Educational
SC Psychology
GA 209FC
UT WOS:000323739000007
ER
PT J
AU Grossi, D
Marcone, R
Cinquegrana, T
Gallucci, M
AF Grossi, D.
Marcone, R.
Cinquegrana, T.
Gallucci, M.
TI On the differential nature of induced and incidental echolalia in autism
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE autism; echolalia; intellectual disability; monitoring processing
ID MIXED TRANSCORTICAL APHASIA; UTILIZATION BEHAVIOR; FRONTAL LOBES;
LANGUAGE; CHILD; COMMUNICATION; VINELAND
AB Background Echolalia is a verbal disorder, defined as a meaningless repetition of the words of others'. It is pathological, automatic and non-intentional behaviour, often observed in a variety of neurological and psychiatric disorders and above all in autism. We assume that echolalia is an imitative behaviour that is due to difficulties in inhibiting automatic repetition as seen in patients with frontal lobe damage. Our aim is to study the occurrence of echolalia under experimental conditions to investigate the nature of the phenomenon and its relationship with the severity of autism. Methods Eighteen participants with autism from 17 to 36 years old were recruited; they were administrated the Vineland scale, the Observational Rating Scale of Basic Functions and the Echolalia Questionnaire. In the Echolalia Questionnaire, questions were directly addressed to the autistic subject (induced procedure) or to the subject's caregiver while the subject was free to do what he wanted (incidental procedure). The data were analysed by multivariate regressions and Pearson's correlations. Results The results showed that echolalia occurred in both experimental situations; the mean value was significantly higher in the induced procedure, but results did not support the correlation with Vineland's score in the incidental procedure. It is likely that the two situations activated different processes. In particular, echolalia was statistically higher in the induced procedure as compared with the incidental one only for subjects with low score on Vineland, but in the incidental procedure, the presence of echolalia appeared to be uninfluenced by the functional capacity of subjects. Conclusions The two experimental conditions require different monitoring systems to control this verbal behaviour. The echolalic phenomenon is an expression of dependence on the environment and may occur in a situation in which the autistic person is participating in a communicative act and, lacking inhibitory control, repeats the other's communication rather than selecting an answer. The deficit in inhibitory control in this situation does not seem to be present in subjects with higher efficiency. Incidental echolalia reflects the inability of the subject to filter out background environmental noise, which occasionally results in environmental dependency.
C1 [Grossi, D.; Marcone, R.; Cinquegrana, T.] Univ Naples 2, Dept Psychol, I-81100 Caserta, Italy.
[Gallucci, M.] AIAS, Autism & Related Disorders Sect, Naples, Italy.
RP Marcone, R (reprint author), Univ Naples 2, Dept Psychol, Via Vivaldi 43, I-81100 Caserta, Italy.
EM roberto.marcone@unina2.it
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NR 41
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD OCT
PY 2013
VL 57
IS 10
BP 903
EP 912
DI 10.1111/j.1365-2788.2012.01579.x
PG 10
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA 206BD
UT WOS:000323490000002
PM 22676294
ER
PT J
AU Shi, GX
Cai, WK
Andres, DA
AF Shi, Geng-Xian
Cai, Weikang
Andres, Douglas A.
TI Rit subfamily small GTPases: Regulators in neuronal differentiation and
survival
SO CELLULAR SIGNALLING
LA English
DT Review
DE Ras GTPase; Rin; MAPK; Neuron; Signaling
ID NERVE GROWTH-FACTOR; RAT SYMPATHETIC NEURONS; COPY NUMBER VARIATIONS;
BINDING PROTEIN RIN; DENDRITIC GROWTH; DOPAMINE TRANSPORTER; SIGNALING
PATHWAY; P38 MAPK; PHEOCHROMOCYTOMA CELLS; HIPPOCAMPAL-NEURONS
AB Ras family small GTPases serve as binary molecular switches to regulate a broad array of cellular signaling cascades, playing essential roles in a vast range of normal physiological processes, with dysregulation of numerous Ras-superfamily G-protein-dependent regulatory cascades underlying the development of human disease. However, the physiological function for many "orphan" Ras-related GTPases remain poorly characterized, including members of the Rit subfamily GTPases. Rit is the founding member of a novel branch of the Ras subfamily, sharing close homology with the neuronally expressed Rin and Drosophila Ric GTPases. Here, we highlight recent studies using transgenic and knockout animal models which have begun to elucidate the physiological roles for the Rit subfamily, including emerging roles in the regulation of neuronal morphology and cellular survival signaling, and discuss new genetic data implicating Rit and Rin signaling in disorders such as cancer, Parkinson's disease, autism, and schizophrenia. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Shi, Geng-Xian; Cai, Weikang; Andres, Douglas A.] Univ Kentucky, Coll Med, Dept Mol & Cellular Biochem, BBSRB, Lexington, KY 40536 USA.
RP Andres, DA (reprint author), Univ Kentucky, Coll Med, Dept Mol & Cellular Biochem, BBSRB, 741S Limestone St, Lexington, KY 40536 USA.
EM dandres@uky.edu
FU Public Health Service Grant from the National Institute of Neurological
Disease's and Stroke (NINDS) [NS045103]; National Center for Research
Resources (NCRR) [2P20 RR020171]; Kentucky Spinal Cord and Head Injury
Research Trust [KSCHIRT 12-1A]; University of Kentucky
FX We apologize to the scientists whose work was not cited due to space
constraints. Research by the authors was supported by Public Health
Service Grant NS045103 from the National Institute of Neurological
Disease's and Stroke (NINDS) (DAA), 2P20 RR020171 from the National
Center for Research Resources (NCRR) (DAA), KSCHIRT 12-1A from the
Kentucky Spinal Cord and Head Injury Research Trust (DAA), and the
University of Kentucky 2012-2013 Research Professorship (DAA). The
content of this article is the responsibility of the authors and does
not necessarily represent the official views of the NIH.
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NR 83
TC 5
Z9 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0898-6568
J9 CELL SIGNAL
JI Cell. Signal.
PD OCT
PY 2013
VL 25
IS 10
BP 2060
EP 2068
DI 10.1016/j.cellsig.2013.06.002
PG 9
WC Cell Biology
SC Cell Biology
GA 198SX
UT WOS:000322943700013
PM 23770287
ER
PT J
AU Martis, RJ
Acharya, UR
Tan, JH
Petznick, A
Tong, L
Chua, CK
Ng, EYK
AF Martis, Roshan Joy
Acharya, U. Rajendra
Tan, Jen Hong
Petznick, Andrea
Tong, Louis
Chua, Chua Kuang
Ng, Eddie Yin Kwee
TI APPLICATION OF INTRINSIC TIME-SCALE DECOMPOSITION (ITD) TO EEG SIGNALS
FOR AUTOMATED SEIZURE PREDICTION
SO INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
LA English
DT Article
DE Electroencephalogram (EEG); ictal; interictal; energy; fractal
dimension; Hurst exponent; sample entropy; classifier
ID FUZZY SYNCHRONIZATION LIKELIHOOD; NEURAL NETWORK METHODOLOGY; AUTISM
SPECTRUM DISORDER; SUPPORT VECTOR MACHINE; TEMPORAL-LOBE EPILEPSY;
ELECTRICAL-STIMULATION; ALZHEIMERS-DISEASE; APPROXIMATE ENTROPY;
COMPONENT ANALYSIS; DIAGNOSIS
AB Intrinsic time-scale decomposition (ITD) is a new nonlinear method of time-frequency representation which can decipher the minute changes in the nonlinear EEG signals. In this work, we have automatically classified normal, interictal and ictal EEG signals using the features derived from the ITD representation. The energy, fractal dimension and sample entropy features computed on ITD representation coupled with decision tree classifier has yielded an average classification accuracy of 95.67%, sensitivity and specificity of 99% and 99.5%, respectively using 10-fold cross validation scheme. With application of the nonlinear ITD representation, along with conceptual advancement and improvement of the accuracy, the developed system is clinically ready for mass screening in resource constrained and emerging economy scenarios.
C1 [Martis, Roshan Joy; Acharya, U. Rajendra; Tan, Jen Hong; Chua, Chua Kuang] Ngee Ann Polytech, Dept Elect & Comp Engn, Singapore 599489, Singapore.
[Acharya, U. Rajendra] Univ Malaya, Fac Engn, Dept Biomed Engn, Kuala Lumpur, Malaysia.
[Petznick, Andrea] Singapore Eye Res Inst, Singapore 168751, Singapore.
[Tong, Louis] Singapore Natl Eye Ctr, Singapore 168751, Singapore.
[Ng, Eddie Yin Kwee] Nanyang Technol Univ, Sch Mech & Aerosp Engn, Singapore 639798, Singapore.
RP Martis, RJ (reprint author), Ngee Ann Polytech, Dept Elect & Comp Engn, Singapore 599489, Singapore.
EM roshaniitsmst@gmail.com; aru@np.edu.sg
RI Ng, Yin Kwee, Eddie/A-1375-2011
OI Ng, Yin Kwee, Eddie/0000-0002-5701-1080
FU Singapore Ministry of Health under the Translational and Innovation Fund
[MOE2011-TIF-1-G-015]
FX This research was supported by the Singapore Ministry of Health under
the Translational and Innovation Fund MOE2011-TIF-1-G-015.
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NR 71
TC 9
Z9 9
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0129-0657
J9 INT J NEURAL SYST
JI Int. J. Neural Syst.
PD OCT
PY 2013
VL 23
IS 5
AR 1350023
DI 10.1142/S0129065713500238
PG 16
WC Computer Science, Artificial Intelligence
SC Computer Science
GA 200ZD
UT WOS:000323109600004
PM 23924414
ER
PT J
AU Eagleson, KL
Milner, TA
Xie, ZH
Levitt, P
AF Eagleson, Kathie L.
Milner, Teresa A.
Xie, Zhihui
Levitt, Pat
TI Synaptic and extrasynaptic location of the receptor tyrosine kinase met
during postnatal development in the mouse neocortex and hippocampus
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE axon; dendritic spine; synaptogenesis; receptor tyrosine kinase;
hepatocyte growth factor
ID HEPATOCYTE GROWTH-FACTOR; DENDRITIC SPINE MORPHOLOGY; ADENOSINE A(2A)
RECEPTORS; RISK GENE MET; C-MET; SUBCELLULAR-LOCALIZATION; PROTEIN
EXPRESSION; ALZHEIMERS-DISEASE; GONADAL-STEROIDS; FACTOR PROMOTES
AB MET, a replicated autism risk gene, encodes a pleiotropic receptor tyrosine kinase implicated in multiple cellular processes during development and following injury. Previous studies suggest that Met modulates excitatory synapse development in the neocortex and hippocampus, although the underlying mechanism is unknown. The peak of Met expression corresponds to the period of process outgrowth and synaptogenesis, with robust expression in hippocampal and neocortical neuropil. Resolving whether neuropil expression represents presynaptic, postsynaptic or glial localization provides insight into potential mechanisms of Met action. The subcellular distribution of Met was characterized using complementary ultrastructural, in situ proximity ligation assay (PLA), and biochemical approaches. At postnatal day (P) 7, immunoelectron microscopy revealed near-equivalent proportions of Met-immunoreactive pre-(axons and terminals) and postsynaptic (dendritic shafts and spines) profiles in the stratum radiatum in the hippocampal CA1 region. Staining was typically in elements in which the corresponding pre- or postsynaptic apposition was unlabeled. By P21, Met-immunoreactive presynaptic profiles predominated and similar to 20% of Met-expressing profiles were glial. A different distribution of Met-immunoreactive profiles was observed in layer V of somatosensory cortex: Met-labeled spines were rare and a smaller proportion of glial profiles expressed Met. Strikingly, Met-immunoreactive presynaptic profiles predominated over postsynaptic profiles as early as P7. PLA analysis of neurons in vitro and biochemical analysis of tissue subsynaptic fractions confirmed the localization of Met in specific synaptic subcompartments. The study demonstrates that Met is enriched at synapses during development and its activation may modulate synapse formation and stability through both pre- and postsynaptic mechanisms. J. Comp. Neurol. 521: 3241-3259, 2013. (C) 2013 Wiley Periodicals, Inc.
C1 [Eagleson, Kathie L.; Xie, Zhihui; Levitt, Pat] Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90033 USA.
[Eagleson, Kathie L.; Levitt, Pat] Univ So Calif, Keck Sch Med, Dept Cell & Neurobiol, Los Angeles, CA 90033 USA.
[Milner, Teresa A.] Weill Cornell Med Coll, Brain & Mind Res Inst, New York, NY 10065 USA.
[Milner, Teresa A.] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10065 USA.
RP Eagleson, KL (reprint author), Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, 1501 San Pablo St,Rm 237, Los Angeles, CA 90033 USA.
EM keagleso@usc.edu
RI Xie, Zhihui/G-8736-2013
FU National Institutes of Health (NIH) [R01 MH067842, NIH R01 DA08259, HL
098351, P01 HL096571]
FX Grant sponsor: National Institutes of Health (NIH); Grand numbers: R01
MH067842 (to P.L.), NIH R01 DA08259, HL 098351, and P01 HL096571 (to
T.A.M.).
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NR 78
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9967
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD OCT 1
PY 2013
VL 521
IS 14
BP 3241
EP 3259
DI 10.1002/cne.23343
PG 19
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA 188UP
UT WOS:000322220700008
PM 23787772
ER
PT J
AU Grissom, NM
Reyes, TM
AF Grissom, Nicola M.
Reyes, Teresa M.
TI Gestational overgrowth and undergrowth affect neurodevelopment:
similarities and differences from behavior to epigenetics
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Intrauterine growth restriction; Macrosomia; DNA methylation; Dopamine;
Opioid; Mesolimbic
ID HIGH-FAT DIET; LOW-BIRTH-WEIGHT; INTRAUTERINE GROWTH RESTRICTION;
MATERNAL OBESITY; DNA METHYLATION; GENE-EXPRESSION; POSTWEANING DIET;
HUMAN PLACENTA; CHILDREN BORN; AGE
AB The size of an infant at birth, a measure of gestational growth, has been recognized for many years as a biomarker of future risk of morbidity. Both being born small for gestational age (SGA) and being born large for gestational age (LGA), are associated with increased rates of obesity and metabolic disorder, as well as a number of mental disorders including attention deficit/hyperactivity disorder, autism, anxiety, and depression. The common risks raise the question of what neurobiological mechanisms are altered in SGA and LGA offspring. Here we review recent findings allowing for direct comparison of neurobiological outcomes of SGA and LGA in human and animal models. We also present new data highlighting similarities and differences in behavior and neurobiology in our mouse models of SGA and LGA. Overall, there is significant data to support aberrant epigenetic mechanisms, particularly related to DNA methylation, in the brains of SGA and LGA offspring, leading to disruptions in the cell cycle in development and gene expression in adulthood. (C) 2012 ISDN. Published by Elsevier Ltd. All rights reserved.
C1 [Grissom, Nicola M.; Reyes, Teresa M.] Univ Penn, Perelman Sch Med, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA.
RP Reyes, TM (reprint author), Univ Penn, Perelman Sch Med, Smilow Ctr Translat Res 10 131, 3400 Civ Ctr Dr,Bldg 421, Philadelphia, PA 19104 USA.
EM reyestm@mail.med.upenn.edu
FU Brain and Behavior Research Foundation; [MH087978]; [MH091372]
FX We would like to thank Debra Okafor, Zivjena Vucetic, and Ryan
Cunningham for their assistance in completion of the newly reported data
in this paper. Supported by MH087978, MH091372, and a Brain and Behavior
Research Foundation (formerly NARSAD) Young Investigator Grant.
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NR 88
TC 6
Z9 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0736-5748
J9 INT J DEV NEUROSCI
JI Int. J. Dev. Neurosci.
PD OCT
PY 2013
VL 31
IS 6
SI SI
BP 406
EP 414
DI 10.1016/j.ijdevneu.2012.11.006
PG 9
WC Developmental Biology; Neurosciences
SC Developmental Biology; Neurosciences & Neurology
GA 187FA
UT WOS:000322101100008
PM 23201144
ER
PT J
AU Yu, ACL
Abrego-Collier, C
Sonderegger, M
AF Yu, Alan C. L.
Abrego-Collier, Carissa
Sonderegger, Morgan
TI Phonetic Imitation from an Individual-Difference Perspective: Subjective
Attitude, Personality and "Autistic" Traits
SO PLOS ONE
LA English
DT Article
ID SPECTRUM QUOTIENT AQ; VOICE-ONSET-TIME; SPEECH-PERCEPTION;
WORKING-MEMORY; FUNCTIONING AUTISM; TALKER DIFFERENCES; EMPATHY
QUOTIENT; COGNITIVE STYLES; SEX-DIFFERENCES; CONVERGENCE
AB Numerous studies have documented the phenomenon of phonetic imitation: the process by which the production patterns of an individual become more similar on some phonetic or acoustic dimension to those of her interlocutor. Though social factors have been suggested as a motivator for imitation, few studies has established a tight connection between language-external factors and a speaker's likelihood to imitate. The present study investigated the phenomenon of phonetic imitation using a within-subject design embedded in an individual-differences framework. Participants were administered a phonetic imitation task, which included two speech production tasks separated by a perceptual learning task, and a battery of measures assessing traits associated with Autism-Spectrum Condition, working memory, and personality. To examine the effects of subjective attitude on phonetic imitation, participants were randomly assigned to four experimental conditions, where the perceived sexual orientation of the narrator (homosexual vs. heterosexual) and the outcome (positive vs. negative) of the story depicted in the exposure materials differed. The extent of phonetic imitation by an individual is significantly modulated by the story outcome, as well as by the participant's subjective attitude toward the model talker, the participant's personality trait of openness and the autistic-like trait associated with attention switching.
C1 [Yu, Alan C. L.; Abrego-Collier, Carissa] Univ Chicago, Dept Linguist, Phonol Lab, Chicago, IL 60637 USA.
[Sonderegger, Morgan] McGill Univ, Dept Linguist, Montreal, PQ, Canada.
RP Yu, ACL (reprint author), Univ Chicago, Dept Linguist, Phonol Lab, Chicago, IL 60637 USA.
EM aclyu@uchicago.edu
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NR 86
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 30
PY 2013
VL 8
IS 9
AR e74746
DI 10.1371/journal.pone.0074746
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 231NL
UT WOS:000325423500036
PM 24098665
ER
PT J
AU Hughes, C
Waters, M
Allen, D
Obasanjo, I
AF Hughes, Claude
Waters, Michael
Allen, David
Obasanjo, Iyabo
TI Translational toxicology: a developmental focus for integrated research
strategies
SO BMC PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
DE Translational toxicology; Environmental health; Biomarkers
ID AUTISM SPECTRUM DISORDERS; ANTENATAL MAGNESIUM-SULFATE; NEURAL-TUBE
DEFECTS; METABOLIC SYNDROME; CEREBRAL-PALSY; FOLIC-ACID;
ENVIRONMENTAL-FACTORS; POSTMENOPAUSAL WOMEN; PROSPECTIVE COHORT;
MENSTRUAL CYCLES
AB Background: Given that toxicology studies the potential adverse effects of environmental exposures on various forms of life and that clinical toxicology typically focuses on human health effects, what can and should the relatively new term of "translational toxicology" be taken to mean?
Discussion: Our assertion is that the core concept of translational toxicology must incorporate existing principles of toxicology and epidemiology, but be driven by the aim of developing safe and effective interventions beyond simple reduction or avoidance of exposure to prevent, mitigate or reverse adverse human health effects of exposures.
The field of toxicology has now reached a point where advances in multiple areas of biomedical research and information technologies empower us to make fundamental transitions in directly impacting human health. Translational toxicology must encompass four action elements as follows:
1) Assessing human exposures in critical windows across the lifespan
2) Defining modes of action and relevance of data from animal models
3) Use of mathematical models to develop plausible predictions as the basis for
4) Protective and restorative human health interventions.
The discussion focuses on the critical window of in-utero development.
Summary: Exposure assessment, basic toxicology and development of certain categories of mathematical models are not new areas of research; however overtly integrating these in order to conceive, assess and validate effective interventions to mitigate or reverse adverse effects of environmental exposures is our novel opportunity. This is what we should do in translational toxicology so that we have a portfolio of interventional options to improve human health that include both minimizing exposures and specific preventative/restorative/mitigative therapeutics.
C1 [Hughes, Claude] N Carolina State Univ, Quintiles Inc, Morrisville, NC USA.
[Hughes, Claude] Wake Forest Univ, Morrisville, NC USA.
[Hughes, Claude] Duke Univ, Med Ctr, Morrisville, NC USA.
[Waters, Michael; Allen, David] Integrated Lab Syst Inc, Durham, NC USA.
[Obasanjo, Iyabo] Harvard Univ, Cambridge, MA 02138 USA.
RP Hughes, C (reprint author), N Carolina State Univ, Quintiles Inc, Morrisville, NC USA.
EM claude.hughes@quintiles.com
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NR 100
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2210
J9 BMC PHARMACOL TOXICO
JI BMC Pharmacol. Toxicol.
PD SEP 30
PY 2013
VL 14
DI 10.1186/2050-6511-14-51
PG 19
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 227SY
UT WOS:000325136000002
PM 24079609
ER
PT J
AU Ohayon, S
Avni, O
Taylor, AL
Perona, P
Egnor, SER
AF Ohayon, Shay
Avni, Ofer
Taylor, Adam L.
Perona, Pietro
Egnor, S. E. Roian
TI Automated multi-day tracking of marked mice for the analysis of social
behaviour
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE Multiple mice tracking; Long term; Social behaviour; Automated
ID MOUSE MODEL; MUS-MUSCULUS; PHENOTYPES; DROSOPHILA; DEFICITS; ETHOMICS;
AUTISM
AB A quantitative description of animal social behaviour is informative for behavioural biologists and clinicians developing drugs to treat social disorders. Social interaction in a group of animals has been difficult to measure because behaviour develops over long periods of time and requires tedious manual scoring, which is subjective and often non-reproducible. Computer-vision systems with the ability to measure complex social behaviour automatically would have a transformative impact on biology. Here, we present a method for tracking group-housed mice individually as they freely interact over multiple days. Each mouse is bleach-marked with a unique fur pattern. The patterns are automatically learned by the tracking software and used to infer identities. Trajectories are analysed to measure behaviour as it develops over days, beyond the range of acute experiments. We demonstrate how our system may be used to study the development of place preferences, associations and social relationships by tracking four mice continuously for five days. Our system enables accurate and reproducible characterisation of wild-type mouse social behaviour and paves the way for high-throughput long-term observation of the effects of genetic, pharmacological and environmental manipulations. Published by Elsevier B.V.
C1 [Ohayon, Shay; Perona, Pietro] CALTECH, Pasadena, CA 91125 USA.
[Avni, Ofer; Taylor, Adam L.; Egnor, S. E. Roian] Howard Hughes Med Inst, Ashburn, VA 20147 USA.
[Perona, Pietro] CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USA.
RP Ohayon, S (reprint author), CALTECH, 1200 East Calif Blvd, Pasadena, CA 91125 USA.
EM shay.ohayon@gmail.com
FU NIH; Howard Hughes Medical Institute
FX This work is funded by NIH and the Howard Hughes Medical Institute.
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NR 28
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD SEP 30
PY 2013
VL 219
IS 1
BP 10
EP 19
DI 10.1016/j.jneumeth.2013.05.013
PG 10
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 222HX
UT WOS:000324722900002
PM 23810825
ER
PT J
AU Ro, M
Park, J
Nam, M
Bang, HJ
Yang, JW
Choi, KS
Kim, SK
Chung, JH
Kwack, K
AF Ro, MyungJa
Park, JungWon
Nam, Min
Bang, Hee Jung
Yang, Jae Won
Choi, Kyung-Sik
Kim, Su Kang
Chung, Joo-Ho
Kwack, KyuBum
TI Associations between single-nucleotide polymorphism in the FNDC3A and
autism spectrum disorder in a Korean population
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE ASD; SNP; Fibronectin type III domain-containing 3A (FNDC3A)
ID FIBRONECTIN; MODULES
AB Autism spectrum disorder (ASD) is a neurodevelopmental syndrome associated with impairments of reciprocal communication and cognitive function. Associations between single-nucleotide polymorphisms (SNPs) and ASD were analysed by logistic regression. Polymorphisms in fibronectin type III domain-containing 3A (FNDC3A) exhibited significant associations in genotype and diplotype analyses. We conclude that FNDC3A influences the prevalence of ASD. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Ro, MyungJa; Park, JungWon; Kwack, KyuBum] CHA Univ, Dept Biomed Sci, Coll Life Sci, Songnam, South Korea.
[Nam, Min] Seoul Metropolitan Childrens Hosp, Dept Psychiat, Seoul, South Korea.
[Bang, Hee Jung] Ewha Womans Univ, Dept Psychol, Coll Social Sci, Seoul, South Korea.
[Yang, Jae Won] Korea Univ, Coll Med, Ansan Hosp, Dept Psychiat, Ansan, South Korea.
[Choi, Kyung-Sik] Joongbu Univ, Dept Elementary Special Educ, Coll Social Sci, Chungnam, South Korea.
[Kim, Su Kang; Chung, Joo-Ho] Kyung Hee Univ, Sch Med, Kohwang Med Res Inst, Seoul, South Korea.
RP Kwack, K (reprint author), CHA Univ, Dept Biomed Sci, Coll Life Sci, Songnam, South Korea.
EM kbkwack@gmail.com
FU Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of
Korea [A040002]
FX This study was supported by a grant from the Korea Health 21 R&D
Project, Ministry of Health and Welfare, Republic of Korea (A040002).
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NR 11
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PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD SEP 30
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VL 209
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BP 246
EP 248
DI 10.1016/j.psychres.2013.02.028
PG 3
WC Psychiatry
SC Psychiatry
GA 223GA
UT WOS:000324791500020
PM 23639254
ER
PT J
AU Mavel, S
Nadal-Desbarats, L
Blasco, H
Bonnet-Brilhault, F
Barthelemy, C
Montigny, F
Sarda, P
Laumonnier, F
Vourc'h, P
Andres, CR
Emond, P
AF Mavel, Sylvie
Nadal-Desbarats, Lydie
Blasco, Helene
Bonnet-Brilhault, Frederique
Barthelemy, Catherine
Montigny, Frederic
Sarda, Pierre
Laumonnier, Frederic
Vourc'h, Patrick
Andres, Christian R.
Emond, Patrick
TI H-1-C-13 NMR-based urine metabolic profiling in autism spectrum
disorders
SO TALANTA
LA English
DT Article
DE HSQC NMR spectroscopy; Autism spectrum disorders; Urinary metabolites;
OPLS-DA; Metabolomics
ID GAS CHROMATOGRAPHY/MASS SPECTROMETRY; CHILDREN; SPECTROSCOPY;
BIOMARKERS; IDENTIFICATION; INDIVIDUALITY; METABOANALYST; CHEMOMETRICS;
PATHWAYS; DISEASE
AB Autism Spectrum Disorders (ASD) are a group of developmental disorders caused by environmental and genetic factors. Diagnosis is based on behavioral and developmental signs detected before 3 years of age with no reliable biological marker. The purpose of this study was to evaluate the potential use of a 2D NMR-based approach to express the global biochemical signature of autistic individuals compared to normal controls. This technique has greater spectral resolution than to 1D H-1 NMR spectroscopy, which is limited by overlapping signals. The urinary metabolic profiles of 30 autistic and 28 matched healthy children were obtained using a H-1-C-13 NMR-based approach. The data acquired were processed by multivariate orthogonal partial least-squares discriminant analysis (OPLS-DA). Some discriminating metabolites were identified: beta-alanine, glycine, taurine and succinate concentrations were significatively higher, and creatine and 3-methylhistidine concentrations were lower in autistic children than in controls. We also noted differences in several other metabolites that were unidentified but characterized by a cross peak correlation in H-1-C-13 HSQC. Statistical models of H-1 and H-1-C-13 analyses were compared and only 2D spectra allowed the characterization of statistically relevant changes [(RY)-Y-2(cum) = 0.78 and Q(2)(cum)=0.60] in the low abundance metabolites. This method has the potential to contribute to the diagnosis of neurodevelopment disorders but needs to be validated on larger cohorts and on other developmental disorders to define its specificity. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Mavel, Sylvie; Nadal-Desbarats, Lydie; Blasco, Helene; Laumonnier, Frederic; Vourc'h, Patrick; Andres, Christian R.; Emond, Patrick] Univ Tours, INSERM, U930, Equipe Neurogenet & Neurometabolom,CHRU Tours, F-37044 Tours, France.
[Bonnet-Brilhault, Frederique; Barthelemy, Catherine] Univ Tours, INSERM, U930, Equips Autisme,CHRU Tours, F-37044 Tours, France.
[Nadal-Desbarats, Lydie; Montigny, Frederic; Vourc'h, Patrick; Emond, Patrick] Univ Tours, PPF Anal Syst Biol, UFR Med, F-37044 Tours, France.
[Sarda, Pierre] Hop Arnaud de Villeneuve, CHRU Montpellier, F-34295 Montpellier 5, France.
RP Mavel, S (reprint author), Univ Tours, INSERM, U930, Equipe Neurogenet & Neurometabolom,CHRU Tours, 10 Bv Tonnelle, F-37044 Tours, France.
EM sylvie.mavel@univ-tours.fr
FU "Institut National de la Sante et de la Recherche" INSERM
FX This work was supported by the "Institut National de la Sante et de la
Recherche" INSERM and the University Francois-Rabelais. We thank the
center "Sesame Autisme Loiret" for their participation to this study. We
thank the "Departement d'Analyses Chimiques et S. R.M. Biologique et
Medicale" (PPF, Tours, France) for chemical analyses.
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NR 43
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0039-9140
J9 TALANTA
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PY 2013
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BP 95
EP 102
DI 10.1016/j.talanta.2013.03.064
PG 8
WC Chemistry, Analytical
SC Chemistry
GA 212WJ
UT WOS:000324013200016
PM 23953447
ER
PT J
AU Zikopoulos, B
Barbas, H
AF Zikopoulos, Basilis
Barbas, Helen
TI Altered neural connectivity in excitatory and inhibitory cortical
circuits in autism
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE prefrontal cortex (PFC); parvalbumin-positive interneurons; anterior
cingulate cortex; ratio of excitation and inhibition; myelinated axons;
GAP-43; white matter; short-range and long-distance pathways
ID ANTERIOR CINGULATE CORTEX; PRIMARY VISUAL-CORTEX; CALCIUM-BINDING
PROTEINS; MONKEY PREFRONTAL CORTEX; HIGH-FUNCTIONING AUTISM; EFFERENT
ASSOCIATION PATHWAYS; REGULATES INFORMATION-STORAGE; THALAMIC RETICULAR
NUCLEUS; DOPAMINE-BETA-HYDROXYLASE; MESSENGER-RNA EXPRESSION
AB Converging evidence from diverse studies suggests that atypical brain connectivity in autism affects in distinct ways short- and long-range cortical pathways, disrupting neural communication and the balance of excitation and inhibition. This hypothesis is based mostly on functional non-invasive studies that show atypical synchronization and connectivity patterns between cortical areas in children and adults with autism. Indirect methods to study the course and integrity of major brain pathways at low resolution show changes in fractional anisotropy (FA) or diffusivity of the white matter in autism. Findings in post-mortem brains of adults with autism provide evidence of changes in the fine structure of axons below prefrontal cortices, which communicate over short- or long-range pathways with other cortices and subcortical structures. Here we focus on evidence of cellular and axon features that likely underlie the changes in short- and long-range communication in autism. We review recent findings of changes in the shape, thickness, and volume of brain areas, cytoarchitecture, neuronal morphology, cellular elements, and structural and neurochemical features of individual axons in the white matter, where pathology is evident even in gross images. We relate cellular and molecular features to imaging and genetic studies that highlight a variety of polymorphisms and epigenetic factors that primarily affect neurite growth and synapse formation and function in autism. We report preliminary findings of changes in autism in the ratio of distinct types of inhibitory neurons in prefrontal cortex, known to shape network dynamics and the balance of excitation and inhibition. Finally we present a model that synthesizes diverse findings by relating them to developmental events, with a goal to identify common processes that perturb development in autism and affect neural communication, reflected in altered patterns of attention, social interactions, and language.
C1 [Zikopoulos, Basilis; Barbas, Helen] Boston Univ, Dept Hlth Sci, Neural Syst Lab, Boston, MA 02215 USA.
RP Zikopoulos, B (reprint author), Boston Univ, Dept Hlth Sci, Neural Syst Lab, 635 Commonwealth Ave, Boston, MA 02215 USA.
EM zikopoul@bu.edu
FU Autism Speaks; CELEST, the Center of Excellence for Learning in
Education, Science, and Technology (a National Science Foundation
Science of Learning Center) [SBE-0354378]; National Institutes of Health
(National Institute of Mental Health) [RO1MH057414]; National Institute
of Neurological Disorders and Stroke [R01NS024760]
FX We thank Dr. Nenad Bogdanovic for useful comments on the manuscript,
Marcia Feinberg for assistance with electron microscopy, and Mary Louise
Fowler for assistance with cell counts. This work was supported by
grants from: Autism Speaks; CELEST, the Center of Excellence for
Learning in Education, Science, and Technology (a National Science
Foundation Science of Learning Center, grant SBE-0354378) and the
National Institutes of Health (National Institute of Mental Health
RO1MH057414, and the National Institute of Neurological Disorders and
Stroke, R01NS024760). We gratefully acknowledge the families of the
donors and the following brain banks that make post-mortem research
possible: The Autism Tissue Program (ATP; Dr. Jane Pickett, Director),
The Eunice Kennedy Shriver NICHD Brain and Tissue Bank at the University
of Maryland, Baltimore, MD, USA (Dr. Ronald Zielke, Director), and the
Harvard Brain and Tissue Resource Center (HBTRC; Dr. Francine Benes,
Director).
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NR 310
TC 20
Z9 21
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 27
PY 2013
VL 7
BP 1
EP 24
DI 10.3389/fnhum.2013.00609
PG 24
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 224CV
UT WOS:000324860300001
PM 24098278
ER
PT J
AU Falck-Ytter, T
Bolte, S
Gredeback, G
AF Falck-Ytter, Terje
Bolte, Sven
Gredeback, Gustaf
TI Eye tracking in early autism research
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Review
ID INFANTS AT-RISK; SPECTRUM DISORDERS; BIOLOGICAL MOTION; YOUNG-CHILDREN;
SOCIAL SCENES; DEVELOPMENTAL-CHANGES; ATYPICAL DEVELOPMENT; 6-MONTH-OLD
INFANTS; ASPERGER SYNDROME; VISUAL TRACKING
AB Eye tracking has the potential to characterize autism at a unique intermediate level, with links 'down' to underlying neurocognitive networks, as well as 'up' to everyday function and dysfunction. Because it is non-invasive and does not require advanced motor responses or language, eye tracking is particularly important for the study of young children and infants. In this article, we review eye tracking studies of young children with autism spectrum disorder (ASD) and children at risk for ASD. Reduced looking time at people and faces, as well as problems with disengagement of attention, appear to be among the earliest signs of ASD, emerging during the first year of life. In toddlers with ASD, altered looking patterns across facial parts such as the eyes and mouth have been found, together with limited orienting to biological motion. We provide a detailed discussion of these and other key findings and highlight methodological opportunities and challenges for eye tracking research of young children with ASD. We conclude that eye tracking can reveal important features of the complex picture of autism.
C1 [Falck-Ytter, Terje; Bolte, Sven] Karolinska Inst KIND, Dept Womens & Childrens Hlth, Child & Adolescent Psychiat Res Ctr, Pediat Neuropsychiat Unit,Ctr Neurodev Disordes, SE-11330 Stockholm, Sweden.
[Falck-Ytter, Terje; Gredeback, Gustaf] Uppsala Univ, Dept Psychol, Uppsala Child & Babylab, Uppsala, Sweden.
[Bolte, Sven] Stockholm Cty Council, Div Child & Adolescent Psychiat, Stockholm, Sweden.
RP Falck-Ytter, T (reprint author), Karolinska Inst KIND, Dept Womens & Childrens Hlth, Child & Adolescent Psychiat Res Ctr, Pediat Neuropsychiat Unit,Ctr Neurodev Disordes, Gavlegatan 22, SE-11330 Stockholm, Sweden.
EM terje.falck-ytter@ki.se
RI Gredeback, Gustaf/C-1676-2009
OI Gredeback, Gustaf/0000-0003-3046-0043
FU Swedish Research Council [259-2012-24, 523-2009-7054]; FAS; FORMAS;
VINNOVA; ESF COST Action [BM1004]; The Bank of Sweden Tercentenary
Foundation [P12-0270:1]; The Sven Jerring Foundation
FX This research was supported by a grant to all authors from the Swedish
Research Council in partnership with FAS, FORMAS, and VINNOVA
(Cross-disciplinary research programme concerning children's and young
people's mental health; grant number 259-2012-24). The work of TFY and
SB was supported by the ESF COST Action BM1004 'Enhancing the Scientific
Study of Early Autism' (ESSEA). TFY was supported by The Bank of Sweden
Tercentenary Foundation [P12-0270:1] and The Sven Jerring Foundation. SB
was supported by the Swedish Research Council [Nr. 523-2009-7054]. GG
was supported by the European Research Council (StG - CACTUS 312292). SB
and GG were supported by The Bank of Sweden Tercentenary Foundation
(P10-0785).
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NR 120
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD SEP 26
PY 2013
VL 5
AR 28
DI 10.1186/1866-1955-5-28
PG 13
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 231ET
UT WOS:000325397700001
PM 24069955
ER
PT J
AU Blair, DR
Lyttle, CS
Mortensen, JM
Bearden, CF
Jensen, AB
Khiabanian, H
Melamed, R
Rabadan, R
Bernstam, EV
Brunak, S
Jensen, LJ
Nicolae, D
Shah, NH
Grossman, RL
Cox, NJ
White, KP
Rzhetsky, A
AF Blair, David R.
Lyttle, Christopher S.
Mortensen, Jonathan M.
Bearden, Charles F.
Jensen, Anders Boeck
Khiabanian, Hossein
Melamed, Rachel
Rabadan, Raul
Bernstam, Elmer V.
Brunak, Soren
Jensen, Lars Juhl
Nicolae, Dan
Shah, Nigam H.
Grossman, Robert L.
Cox, Nancy J.
White, Kevin P.
Rzhetsky, Andrey
TI A Nondegenerate Code of Deleterious Variants in Mendelian Loci
Contributes to Complex Disease Risk
SO CELL
LA English
DT Article
ID TERT PROMOTER MUTATIONS; BARDET-BIEDL-SYNDROME; RETINITIS-PIGMENTOSA;
MENTAL-RETARDATION; MODIFIER GENES; AUTISM; DISORDERS; SCHIZOPHRENIA;
PATHOGENESIS; INHERITANCE
AB Although countless highly penetrant variants have been associated with Mendelian disorders, the genetic etiologies underlying complex diseases remain largely unresolved. By mining the medical records of over 110 million patients, we examine the extent to which Mendelian variation contributes to complex disease risk. We detect thousands of associations between Mendelian and complex diseases, revealing a nondegenerate, phenotypic code that links each complex disorder to a unique collection of Mendelian loci. Using genome-wide association results, we demonstrate that common variants associated with complex diseases are enriched in the genes indicated by this "Mendelian code.'' Finally, we detect hundreds of comorbidity associations among Mendelian disorders, and we use probabilistic genetic modeling to demonstrate that Mendelian variants likely contribute nonadditively to the risk for a subset of complex diseases. Overall, this study illustrates a complementary approach for mapping complex disease loci and provides unique predictions concerning the etiologies of specific diseases.
C1 [Blair, David R.] Univ Chicago, Comm Genet Genom & Syst Biol, Chicago, IL 60637 USA.
[Lyttle, Christopher S.] Univ Chicago, Ctr Hlth & Social Sci, Chicago, IL 60637 USA.
[Nicolae, Dan] Univ Chicago, Dept Stat, Chicago, IL 60637 USA.
[Nicolae, Dan; Grossman, Robert L.; Cox, Nancy J.; White, Kevin P.; Rzhetsky, Andrey] Univ Chicago, Dept Med, Chicago, IL 60637 USA.
[Nicolae, Dan; Cox, Nancy J.; White, Kevin P.; Rzhetsky, Andrey] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA.
[Grossman, Robert L.; White, Kevin P.; Rzhetsky, Andrey] Univ Chicago, Inst Genom & Syst Biol, Computat Inst, Chicago, IL 60637 USA.
[Mortensen, Jonathan M.; Shah, Nigam H.] Stanford Ctr Biomed Informat Res, Stanford, CA 94305 USA.
[Bearden, Charles F.; Bernstam, Elmer V.] Univ Texas Hlth Sci Ctr Houston, Dept Internal Med, Sch Biomed Informat, Houston, TX 77030 USA.
[Jensen, Anders Boeck; Brunak, Soren; Jensen, Lars Juhl] Tech Univ Denmark, Ctr Biol Sequence Anal, DK-2800 Copenhagen, Denmark.
[Khiabanian, Hossein; Melamed, Rachel; Rabadan, Raul] Columbia Univ, Ctr Computat Biol & Bioinformat, Dept Biomed Informat, New York, NY 10032 USA.
[Brunak, Soren; Jensen, Lars Juhl] Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, DK-2200 Copenhagen, Denmark.
RP White, KP (reprint author), Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA.
EM kpwhite@uchicago.edu; arzhetsky@uchicago.edu
RI Hvam, Lars/O-4313-2014
FU National Institutes of Health [1P50MH094267, NHLBI MAPGen
U01HL108634-01, P50GM081892-01A1, 2T32GM007281-39]; Chicago Biomedical
Consortium
FX We are grateful to Steven Bagley, Richard R. Hudson, Ivan Iossifov,
Ravinesh Kumar, Simon Lovestone, Fabiola Rivas, Gregory Gibson, Jason
Pitt, Rita Rzhetsky, Michael Wigler, and anonymous reviewers for helpful
comments on earlier versions of the manuscript. GeneXplain, GmbH,
provided help with annotation of Mendelian disorders. This work was
supported by grants (1P50MH094267, NHLBI MAPGen U01HL108634-01,
P50GM081892-01A1, and 2T32GM007281-39) from the National Institutes of
Health and by a Lever Award from the Chicago Biomedical Consortium.
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SN 0092-8674
J9 CELL
JI Cell
PD SEP 26
PY 2013
VL 155
IS 1
BP 70
EP 80
DI 10.1016/j.cell.2013.08.030
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 224UX
UT WOS:000324916700010
PM 24074861
ER
PT J
AU McGrath, J
Johnson, K
O'Hanlon, E
Garavan, H
Leemans, A
Gallagher, L
AF McGrath, Jane
Johnson, Katherine
O'Hanlon, Erik
Garavan, Hugh
Leemans, Alexander
Gallagher, Louise
TI Abnormal functional connectivity during visuospatial processing is
associated with disrupted organisation of white matter in autism
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE neuroimaging; autism spectrum disorders; functional connectivity;
diffusion tractography; constrained spherical deconvolution;
visuospatial processing; structural connectivity; mental rotation
ID DIFFUSION-WEIGHTED MRI; EMBEDDED FIGURES TASK; CORPUS-CALLOSUM;
RESTING-STATE; SPECTRUM DISORDER; SPHERICAL DECONVOLUTION; HUMAN BRAIN;
CORTICAL UNDERCONNECTIVITY; STRUCTURAL CONNECTIVITY; FRACTIONAL
ANISOTROPY
AB Disruption of structural and functional neural connectivity has been widely reported in Autism Spectrum Disorder (ASD) but there is a striking lack of research attempting to integrate analysis of functional and structural connectivity in the same study population, an approach that may provide key insights into the specific neurobiological underpinnings of altered functional connectivity in autism. The aims of this study were (1) to determine whether functional connectivity abnormalities were associated with structural abnormalities of white matter (WM) in ASD and (2) to examine the relationships between aberrant neural connectivity and behavior in ASD. Twenty-two individuals with ASD and 22 age, IQ-matched controls completed a high-angular-resolution diffusion MRI scan. Structural connectivity was analysed using constrained spherical deconvolution (CSD) based tractography. Regions for tractography were generated from the results of a previous study, in which 10 pairs of brain regions showed abnormal functional connectivity during visuospatial processing in ASD. WM tracts directly connected 5 of the 10 region pairs that showed abnormal functional connectivity; linking a region in the left occipital lobe (left BA19) and five paired regions: left caudate head, left caudate body, left uncus, left thalamus, and left cuneus. Measures of WM microstructural organization were extracted from these tracts. Fractional anisotropy (FA) reductions in the ASD group relative to controls were significant for WM connecting left BA19 to left caudate head and left BA19 to left thalamus. Using a multimodal imaging approach, this study has revealed aberrant WM microstructure in tracts that directly connect brain regions that are abnormally functionally connected in ASD. These results provide novel evidence to suggest that structural brain pathology may contribute (1) to abnormal functional connectivity and (2) to atypical visuospatial processing in ASD.
C1 [McGrath, Jane; Johnson, Katherine; Garavan, Hugh; Gallagher, Louise] Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland.
[Johnson, Katherine] Univ Melbourne, Dept Psychol, Melbourne, Vic, Australia.
[O'Hanlon, Erik] Royal Coll Surgeons Ireland, Dept Psychiat, Dublin 2, Ireland.
[Garavan, Hugh] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA.
[Leemans, Alexander] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands.
RP McGrath, J (reprint author), St James Hosp, Trinity Ctr Hlth Sci, Dept Psychiat, Dublin 8, Ireland.
EM jane.mcgrath@tcd.ie
RI Leemans, Alexander/A-1784-2011
FU MolecularMedicine Ireland who funded this work [4AA-G04005-0-S06];
IITAC; HEA; National Development Plan; Trinity Centre for High
Performance
FX We wish to thank all the families who participated in this study, Mr.
Sean Brennan and Dr. Miriam Law-Smith for help with recruitment, and Dr.
Flavio Dell'Acqua, Dr. Marco Catani, Dr. Dara Cannon, and Dr. Stephen
Meredith for expert advice on setting up the study. We gratefully
acknowledge the support of MolecularMedicine Ireland who funded this
work (grant number 4AA-G04005-0-S06), IITAC, the HEA, the National
Development Plan and the Trinity Centre for High Performance Computing
and thank Mr. Brendan Behan,Mr. Sojo Joseph, and many others for their
invaluable assistance during the study.
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NR 74
TC 5
Z9 5
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 26
PY 2013
VL 7
AR 434
DI 10.3389/fnhum.2013.00434
PG 18
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 224TK
UT WOS:000324912100001
PM 24133425
ER
PT J
AU Jung, CR
Lin, YT
Hwang, BF
AF Jung, Chau-Ren
Lin, Yu-Ting
Hwang, Bing-Fang
TI Air Pollution and Newly Diagnostic Autism Spectrum Disorders: A
Population-Based Cohort Study in Taiwan
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; NITROGEN-DIOXIDE; CHILDREN;
EXPOSURE; OZONE; BRAIN; RISK; RAT; MECHANISMS
AB There is limited evidence that long-term exposure to ambient air pollution increases the risk of childhood autism spectrum disorder (ASD). The objective of the study was to investigate the associations between long-term exposure to air pollution and newly diagnostic ASD in Taiwan. We conducted a population-based cohort of 49,073 children age less than 3 years in 2000 that were retrieved from Taiwan National Insurance Research Database and followed up from 2000 through 2010. Inverse distance weighting method was used to form exposure parameter for ozone (O-3), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and particles with aerodynamic diameter less than 10 mu m (PM10). Time-dependent Cox proportional hazards (PH) model was performed to evaluate the relationship between yearly average exposure air pollutants of preceding years and newly diagnostic ASD. The risk of newly diagnostic ASD increased according to increasing O-3, CO, NO2, and SO2 levels. The effect estimate indicating an approximately 59% risk increase per 10 ppb increase in O-3 level (95% CI 1.42-1.79), 37% risk increase per 10 ppb in CO (95% CI 1.31-1.44), 340% risk increase per 10 ppb increase in NO2 level (95% CI 3.31-5.85), and 17% risk increase per 1 ppb in SO2 level (95% CI 1.09-1.27) was stable with different combinations of air pollutants in the multi-pollutant models. Our results provide evident that children exposure to O-3, CO, NO2, and SO2 in the preceding 1 year to 4 years may increase the risk of ASD diagnosis.
C1 [Jung, Chau-Ren; Lin, Yu-Ting; Hwang, Bing-Fang] China Med Univ, Coll Publ Hlth, Dept Occupat Safety & Hlth, Taichung, Taiwan.
RP Hwang, BF (reprint author), China Med Univ, Coll Publ Hlth, Dept Occupat Safety & Hlth, Taichung, Taiwan.
EM bfhwang@mail.cmu.edu.tw
FU China Medical University [100-Award-07]
FX This study was supported by grant CMU#100-Award-07 from China Medical
University. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
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NR 46
TC 9
Z9 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 25
PY 2013
VL 8
IS 9
AR e75510
DI 10.1371/journal.pone.0075510
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 228VC
UT WOS:000325218700093
PM 24086549
ER
PT J
AU Xu, XJ
Shou, XJ
Li, J
Jia, MX
Zhang, JS
Guo, Y
Wei, QY
Zhang, XT
Han, SP
Zhang, R
Han, JS
AF Xu, Xin-Jie
Shou, Xiao-Jing
Li, Jin
Jia, Mei-Xiang
Zhang, Ji-Shui
Guo, Yan
Wei, Qing-Yun
Zhang, Xiu-Ting
Han, Song-Ping
Zhang, Rong
Han, Ji-Sheng
TI Mothers of Autistic Children: Lower Plasma Levels of Oxytocin and
Arg-Vasopressin and a Higher Level of Testosterone
SO PLOS ONE
LA English
DT Article
ID ARGININE-VASOPRESSIN; SPECTRUM DISORDER; SOCIAL-BEHAVIOR; GENES; BRAIN;
MECHANISMS; PHENOTYPE; PARENTS; BROADER; WOMEN
AB Background: Autism is a pervasive neurodevelopmental disorder, thought to be caused by a combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers of autistic children. We hypothesized that dysregulation of oxytocin (OXT), Arg-vasopressin (AVP) and sex hormones, found in autistic children, may also exist in their mothers.
Methods: We determined plasma levels of OXT (40 in autism vs. 26 in control group), AVP (40 vs. 17) and sex hormones (61 vs. 47) in mothers of autistic and normal children by enzyme immunoassay and radioimmunoassay, respectively and investigated their relationships with the children's autistic behavior scores (Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC)).
Results: Significantly lower plasma concentrations of OXT (p<0.001) and AVP (p<0.001), as well as a higher level of plasma testosterone (p<0.05), were found in mothers of autistic children vs. those of control. The children's autistic behavior scores were negatively associated with maternal plasma levels of OXT and AVP.
Conclusions: These results suggest that dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children, which may impact children's susceptibility to autism.
C1 [Xu, Xin-Jie; Shou, Xiao-Jing; Li, Jin; Zhang, Rong; Han, Ji-Sheng] Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100871, Peoples R China.
[Xu, Xin-Jie; Shou, Xiao-Jing; Li, Jin; Zhang, Rong; Han, Ji-Sheng] Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100871, Peoples R China.
[Xu, Xin-Jie; Shou, Xiao-Jing; Li, Jin; Zhang, Rong; Han, Ji-Sheng] Peking Univ, Minist Educ, Key Lab Neurosci, Natl Hlth & Family Planning Commiss, Beijing 100871, Peoples R China.
[Jia, Mei-Xiang] Peking Univ, Mental Hlth Inst, Beijing 100871, Peoples R China.
[Zhang, Ji-Shui] Capital Univ Med Sci, Beijing Childrens Hosp, Dept Neurol, Beijing, Peoples R China.
[Zhang, Ji-Shui] Capital Univ Med Sci, Beijing Childrens Hosp, Ctr Rehabil, Beijing, Peoples R China.
[Guo, Yan] Beijing Univ Chinese Med, Dept Ophthalmol, Affiliated Hosp 3, Beijing, Peoples R China.
[Wei, Qing-Yun] Beijing Yangguang Youyi Rehabil Ctr, Beijing, Peoples R China.
[Zhang, Xiu-Ting] Beijing Tongkang Rehabil Ctr, Beijing, Peoples R China.
[Han, Song-Ping] HANS Int Inc, Belle Mead, NJ USA.
RP Zhang, R (reprint author), Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100871, Peoples R China.
EM zhangrong@bjmu.edu.cn; hanjisheng@bjmu.edu.cn
FU National Natural Science Foundation of China [81271507]; Peking
University
FX This project was supported by grants from the National Natural Science
Foundation of China (81271507, http://www.nsfc.gov.cn/) to JSH. The
study was also supported by Peking University Special Project for
promoting joint research between basic and clinical sciences
(http://www.pku.edu.cn/). The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
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NR 37
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 25
PY 2013
VL 8
IS 9
AR e74849
DI 10.1371/journal.pone.0074849
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 228VC
UT WOS:000325218700043
PM 24086383
ER
PT J
AU Larson, T
Lundstom, S
Nilsson, T
Selinus, EN
Rastam, M
Lichtenstein, P
Gumpert, CH
Anckarsater, H
Kerekes, N
AF Larson, Tomas
Lundstom, Sebastian
Nilsson, Thomas
Selinus, Eva Noren
Rastam, Maria
Lichtenstein, Paul
Gumpert, Clara Hellner
Anckarsater, Henrik
Kerekes, Nora
TI Predictive properties of the A-TAC inventory when screening for
childhood-onset neurodevelopmental problems in a population-based sample
SO BMC PSYCHIATRY
LA English
DT Article
DE Autism, Tics, AD/HD, and other Co-morbidities inventory; A-TAC;
Screening; Mental disorders diagnosed in childhood; Co-morbidity; Cohort
studies; Predictive value of tests; Sensitivity and specificity
ID AUTISM SPECTRUM DISORDERS; TELEPHONE INTERVIEW; ASPERGER-SYNDROME;
PERFORMANCE; ADHD; TICS; ADULTS; AD/HD; TESTS; TWINS
AB Background: Identifying children with childhood-onset neurodevelopmental problems (NDPs, defined here as autism spectrum disorders [ASDs], attention-deficit/hyperactivity disorder [AD/HD], tic disorders [TDs], learning disorders [LDs] and development coordination disorder), using easily administered screening instruments, is a prerequisite for epidemiological research. Such instruments are also clinically useful to prioritize children for comprehensive assessments, to screen risk groups, and to follow controls.
Autism-Tics, ADHD, and other Co-morbidities inventory (A-TAC) was developed to meet these requirements; here the A-TAC's prospective and psychometric properties are examined, when used in a population-based, epidemiological setting.
Methods: Since 2004, parents of all Swedish twins have been asked to take part in an ongoing, nation-wide twin study (The Child and Adolescent Twin Study in Sweden). The study includes the A-TAC, carried out as a telephone interview with parents of twins aged 9 or 12. In the present study, screen-positive twins from three birth year cohorts (1993-1995) were invited to a comprehensive clinical follow-up (blinded for previous screening results) together with their co-twins and randomly selected, healthy controls at age 15 (Total N = 452).
Results: Sensitivity and specificity of A-TAC scores for predicting later clinical diagnoses were good to excellent overall, with values of the area under the receiver operating characteristics curves ranging from 0.77 (AD/HD) to 0.91 (ASDs). Among children who were screen-positive for an ASD, 48% received a clinical diagnosis of ASDs. For AD/HD, the corresponding figure was also 48%, for LDs 16%, and for TDs 60%. Between 4% and 35% of screen-positive children did not receive any diagnosis at the clinical follow-up three years later. Among screen-negative controls, prevalence of ASDs, AD/HD, LDs, and TDs was 0%, 7%, 4%, and 2%, respectively.
Conclusions: The A-TAC appeared to be a valid instrument to assess NDPs in this population-based, longitudinal study. It has good-to-excellent psychometric properties, with an excellent ability to distinguish NDPs (mainly ASDs) from non-NDPs at least three years after the screening evaluations, although specific diagnoses did not correspond closely to actual clinical diagnoses.
C1 [Larson, Tomas; Anckarsater, Henrik] Lund Univ, Dept Clin Sci, Malmo, Sweden.
[Rastam, Maria] Lund Univ, Dept Clin Sci, Lund, Sweden.
[Lundstom, Sebastian; Nilsson, Thomas; Anckarsater, Henrik; Kerekes, Nora] Univ Gothenburg, Ctr Eth Law & Mental Hlth CELAM, Gothenburg, Sweden.
[Lundstom, Sebastian; Kerekes, Nora] Swedish Prison & Probat Serv, Res & Dev Unit, Gothenburg, Sweden.
[Lundstom, Sebastian] Univ Gothenburg, GNC, Gothenburg, Sweden.
[Selinus, Eva Noren; Gumpert, Clara Hellner] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
[Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
RP Larson, T (reprint author), Lund Univ, Dept Clin Sci, Malmo, Sweden.
EM tomas.larson@med.lu.se
RI Kerekes, Nora/C-6474-2009
FU Swedish Council for Working Life and Social Research; Swedish Research
Council; National Board of Forensic Medicine; Swedish Prison and
Probation Service; Bank of Sweden Tercentenary Foundation;
Soderstrom-Konigska Foundation; Karolinska Institutet Center of
Neurodevelopmental Disorders (KIND); Systembolaget
FX The CATSS/DOGSS project is supported by the Swedish Council for Working
Life and Social Research, the Swedish Research Council, Systembolaget,
the National Board of Forensic Medicine, the Swedish Prison and
Probation Service, the Bank of Sweden Tercentenary Foundation, the
Soderstrom-Konigska Foundation, and the Karolinska Institutet Center of
Neurodevelopmental Disorders (KIND).
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Anckarsater H, 2010, INT J LAW PSYCHIAT, V33, P59, DOI 10.1016/j.ijlp.2009.12.001
Anckarsater H, 2008, OPEN PSYCHIAT J, V2, P5, DOI DOI 10.2174/1874354400802010005
Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
Bergfalk H, 2006, QBTEST USER MANUAL
Biederman J, 2006, J CLIN PSYCHIAT, V67, P524
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Jacobson JW, 2007, HDB INTELLECTUAL DEV, P353, DOI 10.1007/0-387-32931-5_19
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Pezzullo JC, INTERACTIVE STAT RES
Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x
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Tape T. G., INTERPRETING DIAGNOS
Wechsler D, 1997, MANUAL WECHSLER ADUL
NR 33
TC 6
Z9 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD SEP 25
PY 2013
VL 13
AR 233
DI 10.1186/1471-244X-13-233
PG 11
WC Psychiatry
SC Psychiatry
GA 227VX
UT WOS:000325144900001
PM 24066834
ER
PT J
AU Kats, D
Payne, L
Parlier, M
Piven, J
AF Kats, Dmitry
Payne, Leslie
Parlier, Morgan
Piven, Joseph
TI Prevalence of selected clinical problems in older adults with autism and
intellectual disability
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; ASD; Older adults; Clinical problems; Behavior problems;
Intellectual disabilities
ID SPECTRUM DISORDERS; YOUNG-ADULTS; EPIDEMIOLOGY; BEHAVIOR; ADOLESCENTS;
CHILDREN; RATES; RISK
AB Background: Originally described as a disorder of childhood, evidence now demonstrates the lifelong nature of autism spectrum disorder (ASD). Despite the increase of the population over age 65, older adults with ASD remain a scarcely explored subpopulation. This study set out to investigate the prevalence of clinically relevant behaviors and medical problems in a sample of US adults aged 30 to 59 with ASD and intellectual disability (ID), in comparison to those with ID only.
Methods: A cross-sectional study, with both an exploratory and replication analysis, was conducted using National Core Indicators (NCI) multi-state surveys from 2009 to 2010 and 2010 to 2011. There were 4,989 and 4,261 adults aged 30-59 with ID examined from the 2009 to 2010 and 2010 to 2011 samples, respectively. The two consecutive annual samples consisted of 438 (9%) and 298 (7%) individuals with ASD and ID. Variables were chosen from the NCI data as outcomes, including medication use for behavior problems, severe or aggressive behavior problems and selected medical conditions.
Results: No age-associated disparities were observed between adults with ASD and ID versus adults with ID only in either sample. For the 2009 to 2010 sample, the prevalence of support needed to manage self-injurious, disruptive and destructive behavior in subjects with ASD and ID ranged from 40 to 60%. Similarly, the prevalence estimates of self-injurious, disruptive and destructive behavior were each almost double in adults with ASD and ID relative to those with ID only. These results were replicated in the 2010 to 2011 sample.
Conclusions: The findings of this study highlight the urgent need for research on the nature and treatment of severe behavior problems in the rapidly increasing population of older adults with ASD. They also suggest the importance of developing policies that expand our capacity to care for these individuals.
C1 [Payne, Leslie; Parlier, Morgan; Piven, Joseph] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
[Piven, Joseph] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA.
[Kats, Dmitry] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA.
RP Piven, J (reprint author), Univ N Carolina, Carolina Inst Dev Disabil, Campus Box 7255, Chapel Hill, NC 27599 USA.
EM jpiven@med.unc.edu
FU National Center for Research Resources [UL1RR025747]; National
Institutes of Health [1R03MH097070-01]
FX We acknowledge the important contributions of Sergio Starkstein, MD;
Rebecca Edmonson Pretzel, PhD; Mary Lynn Piven, PhD; Peter V Rabins, MD,
MPH; Peggye Dilworth-Anderson, PhD; and Stephen Cole, PhD. This project
was supported by Award Number UL1RR025747 from the National Center for
Research Resources and National Institutes of Health Grant
(1R03MH097070-01). The content is solely the responsibility of the
authors and does not necessarily represent the official views of the
National Center for Research Resources or the National Institutes of
Health.
CR Alzheimer's Association, YOUNG ONS ALZH IM TO
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 32
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD SEP 25
PY 2013
VL 5
AR 27
DI 10.1186/1866-1955-5-27
PG 12
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 231ES
UT WOS:000325397600001
PM 24066979
ER
PT J
AU Nielsen, JA
Zielinski, BA
Fletcher, PT
Alexander, AL
Lange, N
Bigler, ED
Lainhart, JE
Anderson, JS
AF Nielsen, Jared A.
Zielinski, Brandon A.
Fletcher, P. Thomas
Alexander, Andrew L.
Lange, Nicholas
Bigler, Erin D.
Lainhart, Janet E.
Anderson, Jeffrey S.
TI Multisite functional connectivity MRI classification of autism: ABIDE
results
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE functional connectivity; fcMRI; classification; autism; ABIDE
ID SPECTRUM DISORDERS; DIAGNOSTIC INTERVIEW; BRAIN; NETWORKS; CHILDREN;
FMRI; SYNCHRONIZATION; BIOMARKER; DEFICITS; MOTION
AB Background: Systematic differences in functional connectivity MRI metrics have been consistently observed in autism, with predominantly decreased cortico-cortical connectivity. Previous attempts at single subject classification in high-functioning autism using whole brain point-to-point functional connectivity have yielded about 80% accurate classification of autism vs. control subjects across a wide age range. We attempted to replicate the method and results using the Autism Brain Imaging Data Exchange (ABIDE) including resting state fMRI data obtained from 964 subjects and 16 separate international sites.
Methods: For each of 964 subjects, we obtained pairwise functional connectivity measurements from a lattice of 7266 regions of interest covering the gray matter (26.4 million connections) after preprocessing that included motion and slice timing correction, coregistration to an anatomic image, normalization to standard space, and voxelwise removal by regression of motion parameters, soft tissue, CSF, and white matter signals. Connections were grouped into multiple bins, and a leave-one-out classifier was evaluated on connections comprising each set of bins. Age, age-squared, gender, handedness, and site were included as covariates for the classifier.
Results: Classification accuracy significantly outperformed chance but was much lower for multisite prediction than for previous single site results. As high as 60% accuracy was obtained for whole brain classification, with the best accuracy from connections involving regions of the default mode network, parahippocampaland fusiform gyri, insula, Wernicke Area, and intraparietal sulcus. The classifier score was related to symptom severity, social function, daily living skills, and verbal IQ. Classification accuracy was significantly higher for sites with longer BOLD imaging times.
Conclusions: Multisite functional connectivity classification of autism outperformed chance using a simple leave-one-out classifier, but exhibited poorer accuracy than for single site results. Attempts to use multisite classifiers will likely require improved classification algorithms, longer BOLD imaging times, and standardized acquisition parameters for possible future clinical utility.
C1 [Nielsen, Jared A.; Anderson, Jeffrey S.] Univ Utah, Interdepartmental Program Neurosci, Salt Lake City, UT 84112 USA.
[Nielsen, Jared A.] Univ Utah, Dept Psychiat, Salt Lake City, UT 84112 USA.
[Zielinski, Brandon A.] Univ Utah, Dept Pediat, Salt Lake City, UT 84112 USA.
[Zielinski, Brandon A.] Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA.
[Zielinski, Brandon A.] Primary Childrens Med Ctr, Salt Lake City, UT 84103 USA.
[Fletcher, P. Thomas] Univ Utah, Sch Comp & Sci Comp, Salt Lake City, UT 84112 USA.
[Fletcher, P. Thomas] Univ Utah, Imaging Inst, Salt Lake City, UT 84112 USA.
[Alexander, Andrew L.; Lainhart, Janet E.] Univ Wisconsin, Dept Psychiat, Waisman Lab Brain Imaging & Behav, Madison, WI 53706 USA.
[Alexander, Andrew L.] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA.
[Lange, Nicholas] Harvard Univ, Dept Psychiat, Boston, MA 02115 USA.
[Lange, Nicholas] Harvard Univ, Dept Biostat, Boston, MA 02115 USA.
[Lange, Nicholas] McLean Hosp, Neurostat Lab, Belmont, MA 02178 USA.
[Bigler, Erin D.] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA.
[Bigler, Erin D.] Brigham Young Univ, Ctr Neurosci, Provo, UT 84602 USA.
[Bigler, Erin D.; Anderson, Jeffrey S.] Univ Utah, Brain Inst Utah, Salt Lake City, UT 84112 USA.
[Anderson, Jeffrey S.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
[Anderson, Jeffrey S.] Univ Utah, Div Neuroradiol, Salt Lake City, UT 84112 USA.
RP Anderson, JS (reprint author), Univ Utah, Interdepartmental Program Neurosci, 201 Presidents Cir, Salt Lake City, UT 84112 USA.
EM andersonjeffs@gmail.com
FU NIH [K08MH092697, R01MH084795, R01MH080826]; Flamm Family Foundation;
Morrell Family Foundation; Ben B. and Iris M. Margolis Foundation
FX The analysis described was supported by NIH grant numbers K08MH092697
and R01MH084795, R01MH080826, the Flamm Family Foundation, the Morrell
Family Foundation and by the Ben B. and Iris M. Margolis Foundation. The
content is solely the responsibility of the authors and does not
necessarily represent the official views of the National Institute of
Mental Health or the National Institutes of Health. Funding sources for
the datasets comprising the 1000 Functional Connectome Project are
listed at fcon_1000.projects.nitrc.org/fcpClassic/FcpTable.html. Funding
sources for the ABIDE dataset are listed at
fcon_1000.projects.nitrcc.org/indi/abide.
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NR 55
TC 7
Z9 7
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 25
PY 2013
VL 7
AR 599
DI 10.3389/fnhum.2013.00599
PG 12
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 223IZ
UT WOS:000324799200001
PM 24093016
ER
PT J
AU Ben Khelifa, H
Soyah, N
Ben-Abdallah-Bouhjar, I
Gritly, R
Sanlaville, D
Elghezal, H
Saad, A
Mougou-Zerelli, S
AF Ben Khelifa, Hela
Soyah, Najla
Ben-Abdallah-Bouhjar, Inesse
Gritly, Ryma
Sanlaville, Damien
Elghezal, Hatem
Saad, Ali
Mougou-Zerelli, Soumaya
TI Xp22.3 interstitial deletion: A recognizable chromosomal abnormality
encompassing VCX3A and STS genes in a patient with X-linked ichthyosis
and mental retardation
SO GENE
LA English
DT Article
DE STS deficiency; Whole genome analysis; Genomic rearrangements
ID STEROID-SULFATASE DEFICIENCY; DISTAL SHORT ARM; FAMILY; RECOMBINATION;
EPILEPSY; AUTISM; MEMBER; NLGN4; ADHD
AB X-linked ichthyosis is a genetic disorder affecting the skin and caused by a deficit in the steroid sulfatase enzyme (STS), often associated with a recurrent microdeletion at Xp22.31. Most of the STS deleted patients have X-linked ichthyosis as the only clinical feature and it is believed that patients with more complex disorders including mental retardation could be present as a result of contiguous gene deletion. In fact, VCX3A gene, a member of the VCX (variable charge, X chromosome) gene family, was previously proposed as the candidate gene for X-linked non-specific mental retardation in patients with X-linked ichthyosis.
We report on a boy with familial ichthyosis, dysmorphic features and moderate mental retardation with approximately 2 Mb interstitial deletion on Xp22.3 involving VCX3A and STS genes. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Ben Khelifa, Hela; Ben-Abdallah-Bouhjar, Inesse; Elghezal, Hatem; Saad, Ali; Mougou-Zerelli, Soumaya] Farhat Hached Univ, Teaching Hosp, Cytogenet & Reprod Biol Dept, Sousse 4000, Tunisia.
[Ben Khelifa, Hela; Ben-Abdallah-Bouhjar, Inesse; Elghezal, Hatem; Saad, Ali; Mougou-Zerelli, Soumaya] Univ Sousse, Fac Med Sousse, Common Serv Units Res Genet, Tunis, Tunisia.
[Soyah, Najla] Farhat Hached Univ, Teaching Hosp, Dept Pediat, Sousse 4000, Tunisia.
[Gritly, Ryma] Dept Psychiat, Units Res Rehabil, Sousse, Tunisia.
[Sanlaville, Damien] Hospices Civils Lyon, Serv Cytogenet Constitutionnelle, Lyon, France.
RP Mougou-Zerelli, S (reprint author), Farhat Hached Univ, Teaching Hosp, Cytogenet & Reprod Biol Dept, St Ibn El Jazzar, Sousse 4000, Tunisia.
EM mougousoumaya@yahoo.fr
RI sanlaville, damien/M-4716-2014
OI sanlaville, damien/0000-0001-9939-2849
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NR 27
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
J9 GENE
JI Gene
PD SEP 25
PY 2013
VL 527
IS 2
BP 578
EP 583
DI 10.1016/j.gene.2013.06.018
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 210YW
UT WOS:000323872300023
PM 23791652
ER
PT J
AU Campbell, MG
Kohane, IS
Kong, SW
AF Campbell, Malcolm G.
Kohane, Isaac S.
Kong, Sek Won
TI Pathway-based outlier method reveals heterogeneous genomic structure of
autism in blood transcriptome
SO BMC MEDICAL GENOMICS
LA English
DT Article
DE Autism spectrum disorder; Blood gene expression; Nervous system
development; Outliers; Pathways
ID DIFFERENTIAL GENE-EXPRESSION; COPY-NUMBER VARIATION; DE-NOVO MUTATIONS;
LYMPHOBLASTOID CELL-LINES; FRAGILE-X-SYNDROME; SPECTRUM DISORDERS;
FUNCTIONAL IMPACT; LOCAL OUTLIERS; HUMAN-DISEASE; MOUSE MODEL
AB Background: Decades of research strongly suggest that the genetic etiology of autism spectrum disorders (ASDs) is heterogeneous. However, most published studies focus on group differences between cases and controls. In contrast, we hypothesized that the heterogeneity of the disorder could be characterized by identifying pathways for which individuals are outliers rather than pathways representative of shared group differences of the ASD diagnosis.
Methods: Two previously published blood gene expression data sets - the Translational Genetics Research Institute (TGen) dataset (70 cases and 60 unrelated controls) and the Simons Simplex Consortium (Simons) dataset (221 probands and 191 unaffected family members) - were analyzed. All individuals of each dataset were projected to biological pathways, and each sample's Mahalanobis distance from a pooled centroid was calculated to compare the number of case and control outliers for each pathway.
Results: Analysis of a set of blood gene expression profiles from 70 ASD and 60 unrelated controls revealed three pathways whose outliers were significantly overrepresented in the ASD cases: neuron development including axonogenesis and neurite development (29% of ASD, 3% of control), nitric oxide signaling (29%, 3%), and skeletal development (27%, 3%). Overall, 50% of cases and 8% of controls were outliers in one of these three pathways, which could not be identified using group comparison or gene-level outlier methods. In an independently collected data set consisting of 221 ASD and 191 unaffected family members, outliers in the neurogenesis pathway were heavily biased towards cases (20.8% of ASD, 12.0% of control). Interestingly, neurogenesis outliers were more common among unaffected family members (Simons) than unrelated controls (TGen), but the statistical significance of this effect was marginal (Chi squared P < 0.09).
Conclusions: Unlike group difference approaches, our analysis identified the samples within the case and control groups that manifested each expression signal, and showed that outlier groups were distinct for each implicated pathway. Moreover, our results suggest that by seeking heterogeneity, pathway-based outlier analysis can reveal expression signals that are not apparent when considering only shared group differences.
C1 [Campbell, Malcolm G.; Kohane, Isaac S.; Kong, Sek Won] Harvard Univ, Ctr Biomed Informat, Sch Med, Boston, MA 02115 USA.
[Campbell, Malcolm G.; Kohane, Isaac S.; Kong, Sek Won] Childrens Hosp Boston, Informat Program, Boston, MA 02115 USA.
RP Kong, SW (reprint author), Harvard Univ, Ctr Biomed Informat, Sch Med, 10 Shattuck St, Boston, MA 02115 USA.
EM sekwon.kong@childrens.harvard.edu
FU NIMH [P50MH094267, R01MH085143]; NHGRI [U01HG006500]
FX ISK and SWK are supported in part by NIMH P50MH094267, NIMH R01MH085143,
and NHGRI U01HG006500.
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TC 5
Z9 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1755-8794
J9 BMC MED GENOMICS
JI BMC Med. Genomics
PD SEP 24
PY 2013
VL 6
DI 10.1186/1755-8794-6-34
PG 15
WC Genetics & Heredity
SC Genetics & Heredity
GA 235EQ
UT WOS:000325699600001
PM 24063311
ER
PT J
AU Allely, CS
Johnson, PCD
Marwick, H
Lidstone, E
Kocovska, E
Puckering, C
McConnachie, A
Golding, J
Gillberg, C
Wilson, P
AF Allely, Clare S.
Johnson, Paul C. D.
Marwick, Helen
Lidstone, Emma
Kocovska, Eva
Puckering, Christine
McConnachie, Alex
Golding, Jean
Gillberg, Christopher
Wilson, Philip
TI Prediction of 7-year psychopathology from mother-infant joint attention
behaviours: a nested case-control study
SO BMC PEDIATRICS
LA English
DT Article
DE Avon longitudinal study of parents and children (ALSPAC); Autism;
Attention deficit hyperactivity disorder (ADHD); Disruptive behaviour
disorders; Joint attention behaviours
ID INDIVIDUAL-DIFFERENCES; POSTNATAL DEPRESSION; DEFICIT/HYPERACTIVITY
DISORDER; HOME VIDEOTAPES; RISK-FACTORS; CHILDREN; AUTISM; LANGUAGE;
SYMPTOMS; SPEECH
AB Background: To investigate whether later diagnosis of psychiatric disorder can be predicted from analysis of mother-infant joint attention (JA) behaviours in social-communicative interaction at 12 months.
Method: Using data from a large contemporary birth cohort, we examined 159 videos of a mother-infant interaction for joint attention behaviour when children were aged one year, sampled from within the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Fifty-three of the videos involved infants who were later considered to have a psychiatric disorder at seven years and 106 were same aged controls. Psychopathologies included in the case group were disruptive behaviour disorders, oppositional-conduct disorder, attention-deficit/hyperactivity disorder, pervasive development disorder, anxiety and depressive disorders. Psychiatric diagnoses were obtained using the Development and Wellbeing Assessment when the children were seven years old.
Results: None of the three JA behaviours (shared look rate, shared attention rate and shared attention intensity) showed a significant association with the primary outcome of case-control status. Only shared look rate predicted any of the exploratory sub-diagnosis outcomes and was found to be positively associated with later oppositional-conduct disorders (OR [95% CI]: 1.5 [1.0, 2.3]; p = 0.041).
Conclusions: JA behaviours did not, in general, predict later psychopathology. However, shared look was positively associated with later oppositional-conduct disorders. This suggests that some features of JA may be early markers of later psychopathology. Further investigation will be required to determine whether any JA behaviours can be used to screen for families in need of intervention.
C1 [Allely, Clare S.; Lidstone, Emma; Kocovska, Eva; Puckering, Christine; Gillberg, Christopher] Univ Glasgow, RHSC Yorkhill, Inst Hlth & Wellbeing, Glasgow G3 8SJ, Lanark, Scotland.
[Johnson, Paul C. D.; McConnachie, Alex] Univ Glasgow, Robertson Ctr Biostat, Glasgow G12 8QQ, Lanark, Scotland.
[Marwick, Helen] Univ Strathclyde, Natl Ctr Autism Studies, Glasgow, Lanark, Scotland.
[Golding, Jean] Univ Bristol, Sch Social & Community Med, Ctr Child & Adolescent Hlth, Bristol, Avon, England.
[Wilson, Philip] Univ Aberdeen, Ctr Hlth Sci, Ctr Rural Hlth, Inverness IV2 3JH, Scotland.
RP Wilson, P (reprint author), Univ Aberdeen, Ctr Hlth Sci, Ctr Rural Hlth, Old Perth Rd, Inverness IV2 3JH, Scotland.
EM p.wilson@abdn.ac.uk
RI Johnson, Paul/O-9695-2014
OI Johnson, Paul/0000-0001-6663-7520
FU Yorkhill Children's Foundation; Gillberg Neuropsychiatry Centre;
Waterloo Foundation
FX ALSPAC currently receives core support from Wellcome Trust, Medical
Research Council and the University of Bristol. This project was
specifically funded by small grants from the Yorkhill Children's
Foundation, the Gillberg Neuropsychiatry Centre and the Waterloo
Foundation.
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NR 61
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD SEP 24
PY 2013
VL 13
AR 147
DI 10.1186/1471-2431-13-147
PG 9
WC Pediatrics
SC Pediatrics
GA 231IK
UT WOS:000325409700001
PM 24063312
ER
PT J
AU Levit-Binnun, N
Davidovitch, M
Golland, Y
AF Levit-Binnun, Nava
Davidovitch, Michael
Golland, Yulia
TI Sensory and motor secondary symptoms as indicators of brain
vulnerability
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Review
DE Motor; Network neuroscience; Networks; Resilience; Secondary symptoms;
Sensory; Vulnerability
ID NEUROLOGICAL SOFT SIGNS; OBSESSIVE-COMPULSIVE DISORDER; AUTISM SPECTRUM
DISORDERS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; BORDERLINE
PERSONALITY-DISORDER; DEFICIT-HYPERACTIVITY DISORDER;
POSTTRAUMATIC-STRESS-DISORDER; MILD COGNITIVE IMPAIRMENT;
GRAPH-THEORETICAL ANALYSIS; MINOR PHYSICAL ANOMALIES
AB In addition to the primary symptoms that distinguish one disorder from the next, clinicians have identified, yet largely overlooked, another set of symptoms that appear across many disorders, termed secondary symptoms. In the emerging era of systems neuroscience, which highlights that many disorders share common deficits in global network features, the nonspecific nature of secondary symptoms should attract attention. Herein we provide a scholarly review of the literature on a subset of secondary symptoms-sensory and motor. We demonstrate that their pattern of appearance-across a wide range of psychopathologies, much before the full-blown disorder appears, and in healthy individuals who display a variety of negative symptoms-resembles the pattern of appearance of network abnormalities. We propose that sensory and motor secondary symptoms can be important indicators of underlying network aberrations and thus of vulnerable brain states putting individuals at risk for psychopathology following extreme circumstances.
C1 [Levit-Binnun, Nava; Davidovitch, Michael; Golland, Yulia] Interdisciplinary Ctr IDC, Sagol Unit Appl Neurosci, Sch Psychol, IL-46150 Herzliyya, Israel.
[Davidovitch, Michael] Tel Aviv Maccabi Healthcare Serv, IL-68125 Tel Aviv, Israel.
RP Levit-Binnun, N (reprint author), Interdisciplinary Ctr IDC, Sagol Unit Appl Neurosci, Sch Psychol, POB 167, IL-46150 Herzliyya, Israel.
EM navalb@idc.ac.il
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NR 370
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD SEP 24
PY 2013
VL 5
AR 26
DI 10.1186/1866-1955-5-26
PG 21
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 231ER
UT WOS:000325397500001
PM 24063566
ER
PT J
AU Gessaroli, E
Santelli, E
di Pellegrino, G
Frassinetti, F
AF Gessaroli, Erica
Santelli, Erica
di Pellegrino, Giuseppe
Frassinetti, Francesca
TI Personal Space Regulation in Childhood Autism Spectrum Disorders
SO PLOS ONE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; MONKEYS MACACA-MULATTA; NEURAL CIRCUITRY;
AMYGDALA; CHILDREN; IMPAIRMENTS; OXYTOCIN; DISTANCE; FEAR; INDIVIDUALS
AB People appropriately adjust the distance between themselves and others during social interaction, and they may feel discomfort and move away when another person intrudes on their personal space. In the present study, we investigated personal space in children with persistent difficulties in the domain of social behavior, such as children with autism spectrum disorders (ASD), and in children with typical development (TD). The stop-distance paradigm was used to derive estimates of interpersonal distance, before and after a brief interaction with an unfamiliar adult confederate. The results showed that ASD children felt comfortable at a greater distance compared to TD children. Moreover, personal space shrunk after interaction with the confederate in TD children, but it failed to do so in ASD children. These findings reveal that autism deeply affects the regulation of personal space, influencing both its size and flexibility.
C1 [Gessaroli, Erica; di Pellegrino, Giuseppe; Frassinetti, Francesca] Univ Bologna, Dept Psychol, Bologna, Italy.
[Gessaroli, Erica; Frassinetti, Francesca] Fdn Salvatore Maugeri, Clin Lavoro & Riabilitaz, Ist Ricovero & Cura Carattere Sci, Mantua, Castel Goffredo, Italy.
[Santelli, Erica] Ctr Autismo, Reggio Emilia, Italy.
[di Pellegrino, Giuseppe] Ctr Studies & Res Cognit Neurosci, Cesena, Italy.
RP di Pellegrino, G (reprint author), Univ Bologna, Dept Psychol, Bologna, Italy.
EM g.dipellegrino@unibo.it; francesc.frassinetti@unibo.it
FU University of Bologna (Ricerca Fondamentale Orientata); Ministero
Istruzione Universita e Ricerca [2010XPMFW4_009]
FX This work was supported by grants from the University of Bologna
(Ricerca Fondamentale Orientata) to FF and GdP, and from the Ministero
Istruzione Universita e Ricerca (PRIN 2010, protocol number:
2010XPMFW4_009) to GdP. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
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NR 56
TC 4
Z9 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 23
PY 2013
VL 8
IS 9
DI 10.1371/journal.pone.0074959
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 246EK
UT WOS:000326520200062
PM 24086410
ER
PT J
AU Pisula, E
Kawa, R
Szostakiewicz, L
Lucka, I
Kawa, M
Rynkiewicz, A
AF Pisula, Ewa
Kawa, Rafal
Szostakiewicz, Lukasz
Lucka, Izabela
Kawa, Magdalena
Rynkiewicz, Agnieszka
TI Autistic Traits in Male and Female Students and Individuals with High
Functioning Autism Spectrum Disorders Measured by the Polish Version of
the Autism-Spectrum Quotient
SO PLOS ONE
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; GENERAL-POPULATION;
PERSONALITY-TRAITS; EMPATHY QUOTIENT; AQ; PHENOTYPE; CHILDREN; SAMPLE;
ADULTS; RELIABILITY
AB So far no standardized screening instrument for autism spectrum disorders for adults has been developed in Poland. The main aim of the study was to explore the properties of the Polish version of the Autism-Spectrum Quotient (AQ), especially its reliability and discriminating power. The second purpose was to establish whether the pattern of sex and area of study differences in the amount of autistic traits found in other countries also exist in Poland. The groups in the study included students (n = 2819), adults with ASD (n = 60) and a non-clinical sample (n = 60) matched with the ASD group for age, sex, education and place of residence. The Polish version of AQ proved to be reliable, although - as in studies conducted in other countries - the internal consistency coefficients for subscales (with exception for social skill) were low. ASD diagnosis was the most powerful determinant of AQ scores. Sex differences in autistic traits and a relationship between autistic traits and area of study were found.
C1 [Pisula, Ewa; Kawa, Rafal; Kawa, Magdalena] Univ Warsaw, Fac Psychol, Warsaw, Poland.
[Szostakiewicz, Lukasz; Lucka, Izabela; Rynkiewicz, Agnieszka] Med Univ Gdansk, Dept Dev Psychot & Geriatr Psychiat, Gdansk, Poland.
RP Pisula, E (reprint author), Univ Warsaw, Fac Psychol, Warsaw, Poland.
EM ewa.pisula@psych.uw.edu.pl
FU Polish National Science Centre [N N106 352940]; Warsaw University
FX The study was supported by a grant from the Polish National Science
Centre (N N106 352940) and by the Warsaw University. No additional
external funding received for this study. The funding institutions had
no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
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NR 50
TC 3
Z9 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 23
PY 2013
VL 8
IS 9
AR e75236
DI 10.1371/journal.pone.0075236
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 246EK
UT WOS:000326520200091
PM 24086474
ER
PT J
AU Valvo, G
Baldini, S
Brachini, F
Apicella, F
Cosenza, A
Ferrari, AR
Guerrini, R
Muratori, F
Romano, MF
Santorelli, FM
Tancredi, R
Sicca, F
AF Valvo, Giulia
Baldini, Sara
Brachini, Francesca
Apicella, Fabio
Cosenza, Angela
Ferrari, Anna Rita
Guerrini, Renzo
Muratori, Filippo
Romano, Maria Francesca
Santorelli, Filippo M.
Tancredi, Raffaella
Sicca, Federico
TI Somatic Overgrowth Predisposes to Seizures in Autism Spectrum Disorders
SO PLOS ONE
LA English
DT Article
ID HEAD CIRCUMFERENCE; INTELLECTUAL DISABILITY; EEG ABNORMALITIES; 1ST
YEAR; EPILEPSY; CHILDREN; GROWTH; REGRESSION; LIFE; METAANALYSIS
AB Background: Comorbidity of Autism Spectrum Disorders with seizures or abnormal EEG (Autism-Epilepsy Phenotype) suggests shared pathomechanisms, and might be a starting point to identify distinct populations within the clinical complexity of the autistic spectrum. In this study, we tried to assess whether distinct subgroups, having distinctive clinical hallmarks, emerge from this comorbid condition.
Methods: Two-hundred and six individuals with idiopathic Autism Spectrum Disorders were subgrouped into three experimental classes depending on the presence of seizures and EEG abnormalities. Neurobehavioral, electroclinical and auxological parameters were investigated to identify differences among groups and features which increase the risk of seizures. Our statistical analyses used ANOVA, post-hoc multiple comparisons, and the Chi-squared test to analyze continuous and categorical variables. A correspondence analysis was also used to decompose significant Chi-squared and reduce variables dimensions.
Results: The high percentage of children with seizures (28.2% of our whole cohort) and EEG abnormalities (64.1%) confirmed that the prevalence of epilepsy in Autism Spectrum Disorders exceeds that of the general population. Seizures were associated with severe intellectual disability, and not with autism severity. Interestingly, tall stature (without macrocephaly) was significantly associated with EEG abnormalities or later onset seizures. However, isolated macrocephaly was equally distributed among groups or associated with early onset seizures when accompanied by tall stature.
Conclusions: Tall stature seems to be a phenotypic "biomarker" of susceptibility to EEG abnormalities or late epilepsy in Autism Spectrum Disorders and, when concurring with macrocephaly, predisposes to early onset seizures. Growth pattern might act as an endophenotypic marker in Autism-Epilepsy comorbidity, delineating distinct pathophysiological subtypes and addressing personalized diagnostic work-up and therapeutic approaches.
C1 [Valvo, Giulia; Baldini, Sara; Brachini, Francesca; Ferrari, Anna Rita; Guerrini, Renzo; Sicca, Federico] IRCCS Stella Maris Fdn, Epilepsy Neurophysiol & Neurogenet Unit, Pisa, Italy.
[Apicella, Fabio; Cosenza, Angela; Muratori, Filippo; Tancredi, Raffaella] IRCCS Stella Maris Fdn, Dev Psychiat Unit, Pisa, Italy.
[Guerrini, Renzo] Univ Florence, A Meyer Pediat Hosp, Child Neurol Unit, Florence, Italy.
[Romano, Maria Francesca] St Anna Sch Adv Studies, Inst Econ, Pisa, Italy.
[Santorelli, Filippo M.] IRCCS Stella Maris Fdn, Mol Med Unit, Pisa, Italy.
RP Sicca, F (reprint author), IRCCS Stella Maris Fdn, Epilepsy Neurophysiol & Neurogenet Unit, Pisa, Italy.
EM federico.sicca@inpe.unipi.it
RI Romano, Maria Francesca/G-7717-2011
OI Romano, Maria Francesca/0000-0001-8933-125X
FU Telethon - Italy [GGP11188]
FX The financial support of Telethon - Italy (http://www.telethon.it/en;
Grant no. GGP11188) is gratefully acknowledged. The funders had no role
in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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NR 37
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 23
PY 2013
VL 8
IS 9
AR e75015
DI 10.1371/journal.pone.0075015
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 246EK
UT WOS:000326520200070
PM 24086423
ER
PT J
AU Akther, S
Korshnova, N
Zhong, J
Liang, MK
Cherepanov, SM
Lopatina, O
Komleva, YK
Salmina, AB
Nishimura, T
Fakhrul, AA
Hirai, H
Kato, I
Yamamoto, Y
Takasawa, S
Okamoto, H
Higashida, H
AF Akther, Shirin
Korshnova, Natalia
Zhong, Jing
Liang, Mingkun
Cherepanov, Stanislav M.
Lopatina, Olga
Komleva, Yulia K.
Salmina, Alla B.
Nishimura, Tomoko
Fakhrul, Azam A. K. M.
Hirai, Hirokazu
Kato, Ichiro
Yamamoto, Yasuhiko
Takasawa, Shin
Okamoto, Hiroshi
Higashida, Haruhiro
TI CD38 in the nucleus accumbens and oxytocin are related to paternal
behavior in mice
SO MOLECULAR BRAIN
LA English
DT Article
DE Parental behavior; Paternal behavior; Maternal behavior; Retrieval
behavior; Oxytocin; CD38; Nucleus accumbens
ID MEDIAL PREOPTIC AREA; AUTISM SPECTRUM DISORDER; POSTPARTUM FEMALE RATS;
MATERNAL-BEHAVIOR; PEROMYSCUS-CALIFORNICUS; SOCIAL-BEHAVIOR; LACTATING
RATS; ADP-RIBOSE; AFFILIATIVE BEHAVIOR; INSULIN-SECRETION
AB Background: Mammalian sires participate in infant care. We previously demonstrated that sires of a strain of nonmonogamous laboratory mice initiate parental retrieval behavior in response to olfactory and auditory signals from the dam during isolation in a new environment. This behavior is rapidly lost in the absence of such signals when the sires are caged alone. The neural circuitry and hormones that control paternal behavior are not well-understood. CD38, a membrane glycoprotein, catalyzes synthesis of cyclic ADP-ribose and facilitates oxytocin (OT) secretion due to cyclic ADP-ribose-dependent increases in cytosolic free calcium concentrations in oxytocinergic neurons in the hypothalamus. In this paper, we studied CD38 in the nucleus accumbens (NAcc) and the role of OT on paternal pup retrieval behavior using CD38 knockout (CD38(-/-)) mice of the ICR strain.
Results: CD38(-/-) sires failed to retrieve when they were reunited with their pups after isolation together with the mate dams, but not with pup, in a novel cage for 10 min. CD38(-/-) sires treated with a single subcutaneous injection of OT exhibited recovery in the retrieval events when caged with CD38(-/-) dams treated with OT. We introduced human CD38 in the NAcc of CD38(-/-) sires using a lentiviral infection technique and examined the effects of local expression of CD38. Pairs of knockout dams treated with OT and sires expressing CD38 in the NAcc showed more retrieval (83% of wild-type sire levels). Complete recovery of retrieval was obtained in sires with the expression of CD38 in the NAcc in combination with OT administration. Other paternal behaviors, including pup grooming, crouching and huddling, were also more common in CD38(-/-) sires with CD38 expression in the NAcc compared with those in CD38(-/-) sires without CD38 expression in the NAcc.
Conclusions: CD38 in the NAcc and OT are critical in paternal behavior.
C1 [Akther, Shirin; Korshnova, Natalia; Zhong, Jing; Liang, Mingkun; Cherepanov, Stanislav M.; Lopatina, Olga; Komleva, Yulia K.; Salmina, Alla B.; Nishimura, Tomoko; Fakhrul, Azam A. K. M.; Higashida, Haruhiro] Kanazawa Univ, Ctr Child Mental Dev, Kanazawa, Ishikawa 9208640, Japan.
[Akther, Shirin; Zhong, Jing; Liang, Mingkun] Kanazawa Univ, Grad Sch Med Sci, Dept Biophys Genet, Kanazawa, Ishikawa 9208640, Japan.
[Cherepanov, Stanislav M.; Lopatina, Olga; Komleva, Yulia K.; Salmina, Alla B.; Higashida, Haruhiro] Krasnoyarsk State Med Univ, Dept Biochem Med Pharmaceut & Toxicol Chem, Krasnoyarsk 660022, Russia.
[Hirai, Hirokazu] Gunma Univ, Grad Sch Med, Dept Neurophysiol, Maebashi, Gumma 3718511, Japan.
[Kato, Ichiro] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Dept Biochem, Toyama 9300194, Japan.
[Yamamoto, Yasuhiko] Kanazawa Univ, Grad Sch Med Sci, Dept Biochem & Mol Vasc Biol, Kanazawa, Ishikawa 9208640, Japan.
[Takasawa, Shin] Nara Med Univ, Dept Biochem, Kashihara, Nara 6348521, Japan.
[Okamoto, Hiroshi] Tohoku Univ, Grad Sch Med, Dept Adv Biol Sci Regenerat, Sendai, Miyagi 9808575, Japan.
RP Higashida, H (reprint author), Kanazawa Univ, Ctr Child Mental Dev, Kanazawa, Ishikawa 9208640, Japan.
EM haruhiro@med.kanazawa-u.ac.jp
RI Lopatina, Olga/I-9610-2014; Komleva, Yulia/F-3529-2014
FU Core Research for Evolutional Science and Technology, from the Japan
Science and Technology Agency; Ministry of Education, Culture, Sports,
Science and Technology, Japan
FX This work was supported by Core Research for Evolutional Science and
Technology, from the Japan Science and Technology Agency, and the
Strategic Research Program for Brain Sciences from the Ministry of
Education, Culture, Sports, Science and Technology, Japan.
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NR 77
TC 10
Z9 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1756-6606
J9 MOL BRAIN
JI Mol. Brain
PD SEP 23
PY 2013
VL 6
AR 41
DI 10.1186/1756-6606-6-41
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 234LU
UT WOS:000325646500001
PM 24059452
ER
PT J
AU Maxwell, CR
Parish-Morris, J
Hsin, O
Bush, JC
Schultz, RT
AF Maxwell, Christina R.
Parish-Morris, Julia
Hsin, Olivia
Bush, Jennifer C.
Schultz, Robert T.
TI The broad autism phenotype predicts child functioning in autism spectrum
disorders
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Broad autism phenotype; Social functioning
ID INTERGENERATIONAL TRANSMISSION; DIAGNOSTIC INTERVIEW; TRAITS
AB Background: Broad autism phenotype (BAP) is a milder expression of the social and communication impairments seen in autism spectrum disorders (ASD). While prior studies characterized the BAP in unaffected family members of probands with ASD, the relationship between parental BAP traits and proband symptomatology remains poorly understood. This study utilizes the Broad Autism Phenotype Questionnaire (BAPQ) in parents and the Social Responsiveness Scale (SRS) in children to examine this connection. We hypothesized that in families affected by ASD, elevated maternal and paternal BAPQ scores would correlate with greater autism symptomatology in diagnosed children. In an extension of prior research, we also explored this relationship in families with typically developing children (TDC).
Methods: Two hundred and forty-five children with ASD, 129 TDC and all parents were recruited as part of a larger study investigating relationships between genes, brain and behavior. The Autism Diagnostic Interview-Revised (ADI-R), Autism Diagnostic Observation Schedule (ADOS) and expert clinical judgment confirmed ASD diagnoses in children. SRS was collected for all children. Parents completed a self-report BAPQ and an informant report BAPQ for their spouse; an average of self-report and informant report for each parent was used in all analyses.
Results: Mothers and fathers of children with ASD had significantly higher rates of BAP traits as compared to parents of TDC. Maternal and paternal BAPQ total scores were not correlated with child IQ in either group. In the ASD group, 10% of mothers and 21% of fathers scored above the established BAP threshold compared to 4% of TDC parents. Crude regression analyses showed that maternal and paternal BAPQ total scores accounted for significant variance in child SRS scores in both ASD (17.1%) and TDC (19.8%) families.
Conclusions: Our results suggest that broad autism symptomatology in parents is moderately associated with their child's autism symptomatology. This result extended to TDC families, suggesting that the BAPQ and SRS capture subtle, subclinical social variation in both children and adults. These findings could help define multi-generational social impairments in future phenotypic and genetic studies.
C1 [Maxwell, Christina R.; Parish-Morris, Julia; Hsin, Olivia; Bush, Jennifer C.; Schultz, Robert T.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Schultz, Robert T.] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Schultz, Robert T.] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA.
RP Maxwell, CR (reprint author), Childrens Hosp Philadelphia, Ctr Autism Res, 3535 Market St,Suite 860, Philadelphia, PA 19104 USA.
EM christina.r.maxwell@gmail.com
FU Pennsylvania Department of Health (SAP) [4100042728, 4100047863];
National Institutes of Health [NIMH 1RC1MH088791]; Pfizer, Inc;
Institute for Translational Medicine and Therapeutics at the University
of Pennsylvania (Philadelphia, PA, USA)
FX This study was funded by grants from the Pennsylvania Department of
Health ((SAP) #4100042728 and #4100047863), National Institutes of
Health (NIMH 1RC1MH088791) and Pfizer, Inc to RTS. CRM was funded by the
Institute for Translational Medicine and Therapeutics at the University
of Pennsylvania (Philadelphia, PA, USA).
CR Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014
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NR 17
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD SEP 22
PY 2013
VL 5
AR 25
DI 10.1186/1866-1955-5-25
PG 7
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 223NK
UT WOS:000324812300001
PM 24053506
ER
PT J
AU Fan, YS
Ouyang, XM
Peng, JH
Sacharow, S
Tekin, M
Barbouth, D
Bodamer, O
Yusupov, R
Navarrete, C
Heller, AH
Pena, SDJ
AF Fan, Yao-Shan
Ouyang, Xiaomei
Peng, Jinghong
Sacharow, Stephanie
Tekin, Mustafa
Barbouth, Deborah
Bodamer, Olaf
Yusupov, Roman
Navarrete, Christina
Heller, Ana H.
Pena, Sergio D. J.
TI Frequent detection of parental consanguinity in children with
developmental disorders by a combined CGH and SNP microarray
SO MOLECULAR CYTOGENETICS
LA English
DT Article
DE Chromosome microarray; Consanguinity; Developmental disabilities
ID 2-KETOGLUTARATE DEHYDROGENASE-DEFICIENCY; COMPARATIVE GENOMIC
HYBRIDIZATION; COPY NUMBER VARIATIONS; MENTAL-RETARDATION; DISABILITIES;
MORBIDITY; DIAGNOSIS; SMARCAL1
AB Background: Genomic microarrays have been used as the first-tier cytogenetic diagnostic test for patients with developmental delay/intellectual disability, autism spectrum disorders and/or multiple congenital anomalies. The use of SNP arrays has revealed regions of homozygosity in the genome which can lead to identification of uniparental disomy and parental consanguinity in addition to copy number variations. Consanguinity is associated with an increased risk of birth defects and autosomal recessive disorders. However, the frequency of parental consanguinity in children with developmental disabilities is unknown, and consanguineous couples may not be identified during doctor's visit or genetic counseling without microarray.
Results: We studied 607 proband pediatric patients referred for developmental disorders using a 4 x 180 K array containing both CGH and SNP probes. Using 720, 360, 180, and 90 Mb as the expected sizes of homozygosity for an estimated coefficient of inbreeding (F) 1/4, 1/8, 1/16, 1/32, parental consanguinity was detected in 21 cases (3.46%).
Conclusion: Parental consanguinity is not uncommon in children with developmental problems in our study population, and can be identified by use of a combined CGH and SNP chromosome microarray. Identification of parental consanguinity in such cases can be important for further diagnostic testing.
C1 [Fan, Yao-Shan; Ouyang, Xiaomei; Peng, Jinghong] Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33136 USA.
[Fan, Yao-Shan; Ouyang, Xiaomei; Peng, Jinghong] Univ Miami, Miller Sch Med, Mailman Ctr Child Dev, Miami, FL 33136 USA.
[Sacharow, Stephanie; Tekin, Mustafa; Barbouth, Deborah; Bodamer, Olaf] Univ Miami, Miller Sch Med, Dept Human Genet, Miami, FL 33136 USA.
[Yusupov, Roman] Mem Reg Hosp, Miami, FL USA.
[Navarrete, Christina; Heller, Ana H.] Jackson Mem Hosp, Hollywood, FL USA.
[Pena, Sergio D. J.] Nucleo Genet Med, Belo Horizonte, MG, Brazil.
RP Fan, YS (reprint author), Univ Miami, Miller Sch Med, Dept Pathol, Room 7050,1601 NW 12th Ave, Miami, FL 33136 USA.
EM yfan@med.miami.edu
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NR 24
TC 4
Z9 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1755-8166
J9 MOL CYTOGENET
JI Mol. Cytogenet.
PD SEP 20
PY 2013
VL 6
AR 38
DI 10.1186/1755-8166-6-38
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 279TQ
UT WOS:000328982700001
PM 24053112
ER
PT J
AU Cofiel, L
Bassi, DU
Ray, RK
Pietrobon, R
Brentani, H
AF Cofiel, Luciana
Bassi, Debora U.
Ray, Ryan Kumar
Pietrobon, Ricardo
Brentani, Helena
TI Detecting Dissonance in Clinical and Research Workflow for Translational
Psychiatric Registries
SO PLOS ONE
LA English
DT Article
ID RESEARCH DATA-COLLECTION; DATA CAPTURE; TECHNOLOGY; AUTISM; CARE
AB Background: The interplay between the workflow for clinical tasks and research data collection is often overlooked, ultimately making it ineffective.
Questions/purposes: To the best of our knowledge, no previous studies have developed standards that allow for the comparison of workflow models derived from clinical and research tasks toward the improvement of data collection processes
Methods: In this study we used the term dissonance for the occurrences where there was a discord between clinical and research workflows. We developed workflow models for a translational research study in psychiatry and the clinic where its data collection was carried out. After identifying points of dissonance between clinical and research models we derived a corresponding classification system that ultimately enabled us to re-engineer the data collection workflow. We considered (1) the number of patients approached for enrollment and (2) the number of patients enrolled in the study as indicators of efficiency in research workflow. We also recorded the number of dissonances before and after the workflow modification.
Results: We identified 22 episodes of dissonance across 6 dissonance categories: actor, communication, information, artifact, time, and space. We were able to eliminate 18 episodes of dissonance and increase the number of patients approached and enrolled in research study trough workflow modification.
Conclusion: The classification developed in this study is useful for guiding the identification of dissonances and reveal modifications required to align the workflow of data collection and the clinical setting. The methodology described in this study can be used by researchers to standardize data collection process.
C1 [Cofiel, Luciana; Bassi, Debora U.; Brentani, Helena] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo, Brazil.
[Ray, Ryan Kumar] Univ Texas Sch Publ Hlth, Dept Management Policy & Community Hlth, Houston, TX USA.
[Pietrobon, Ricardo] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
RP Cofiel, L (reprint author), Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo, Brazil.
EM cofiel@gmail.com
FU FAPESP [2009/454220-6, 2011/05481-1]
FX Research supported by FAPESP (2009/454220-6 and 2011/05481-1). The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
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TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 20
PY 2013
VL 8
IS 9
AR e75167
DI 10.1371/journal.pone.0075167
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 222YC
UT WOS:000324768000055
PM 24073246
ER
PT J
AU Dufour, N
Redcay, E
Young, L
Mavros, PL
Moran, JM
Triantafyllou, C
Gabrieli, JDE
Saxe, R
AF Dufour, Nicholas
Redcay, Elizabeth
Young, Liane
Mavros, Penelope L.
Moran, Joseph M.
Triantafyllou, Christina
Gabrieli, John D. E.
Saxe, Rebecca
TI Similar Brain Activation during False Belief Tasks in a Large Sample of
Adults with and without Autism
SO PLOS ONE
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; MORAL JUDGMENT; SPECTRUM
DISORDERS; NEURAL BASIS; MIND; COMPREHENSION; FMRI; CHILDREN; CORTEX
AB Reading about another person's beliefs engages 'Theory of Mind' processes and elicits highly reliable brain activation across individuals and experimental paradigms. Using functional magnetic resonance imaging, we examined activation during a story task designed to elicit Theory of Mind processing in a very large sample of neurotypical (N = 462) individuals, and a group of high-functioning individuals with autism spectrum disorders (N = 31), using both region-of-interest and whole-brain analyses. This large sample allowed us to investigate group differences in brain activation to Theory of Mind tasks with unusually high sensitivity. There were no differences between neurotypical participants and those diagnosed with autism spectrum disorder. These results imply that the social cognitive impairments typical of autism spectrum disorder can occur without measurable changes in the size, location or response magnitude of activity during explicit Theory of Mind tasks administered to adults.
C1 [Dufour, Nicholas; Mavros, Penelope L.; Triantafyllou, Christina; Gabrieli, John D. E.; Saxe, Rebecca] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Redcay, Elizabeth] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA.
[Young, Liane] Boston Coll, Dept Psychol, Boston, MA USA.
[Moran, Joseph M.] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA.
[Triantafyllou, Christina; Gabrieli, John D. E.; Saxe, Rebecca] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA.
RP Saxe, R (reprint author), MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA.
EM saxe@mit.edu
FU Simons Foundation; National Science Foundation [095518, 0645960]; Dana
Foundation; John Merck Scholars Grant
FX This work was supported by the Simons Foundation, the National Science
Foundation (grant number 095518), the Dana Foundation, a National
Science Foundation Graduate Research Fellowship (grant number 0645960),
and a John Merck Scholars Grant. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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NR 45
TC 10
Z9 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 20
PY 2013
VL 8
IS 9
AR e75468
DI 10.1371/journal.pone.0075468
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 222YC
UT WOS:000324768000077
PM 24073267
ER
PT J
AU Baker, JP
AF Baker, Jeffrey P.
TI HISTORY OF MEDICINE Autism at 70-Redrawing the Boundaries
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Editorial Material
ID SPECTRUM DISORDERS
AB Though the DSM-5 definition of autism refers to it as a spectrum, in important ways it represents an effort to define the syndrome more sharply. It thus reflects one of the central themes in the history of autism: a debate over where to set its boundaries. This year's revision of the diagnostic criteria for autism is among the most contentious of any in the new Diagnostic and Statistical Manual of Mental Disorders (the fifth edition, or DSM-5), provoking widespread fears among parents and advocacy groups that children who have received a diagnosis of autism will lose their eligibility for services. Coincidentally, this year also marks the 70th anniversary of psychiatrist Leo Kanner's first clinical description of autism in 1943.(1) Though the DSM-5 definition explicitly refers to autism as a spectrum, in important ways it represents an effort to define the syndrome more sharply. In this respect, ...
C1 Duke Univ, Sch Med, Trent Ctr Bioeth Humanities & Hist Med, Durham, NC USA.
RP Baker, JP (reprint author), Duke Univ, Sch Med, Trent Ctr Bioeth Humanities & Hist Med, Durham, NC USA.
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NR 5
TC 3
Z9 4
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD SEP 19
PY 2013
VL 369
IS 12
BP 1089
EP 1091
DI 10.1056/NEJMp1306380
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 220BD
UT WOS:000324554800004
PM 24047057
ER
PT J
AU Unwin, LM
Maybery, MT
Wray, JA
Whitehouse, AJO
AF Unwin, Lisa M.
Maybery, Murray T.
Wray, John A.
Whitehouse, Andrew J. O.
TI A "bottom-up" approach to aetiological research in autism spectrum
disorders
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE autism spectrum disorders; heterogeneity; autism phenotype
ID LOW-BIRTH-WEIGHT; MOTOR DEVELOPMENT; CHILDREN; ANTIDEPRESSANTS;
POPULATION; SEROTONIN; EXPOSURE; RISK; AGE; CHROMOSOME-2
AB Autism spectrum disorders (ASD) are currently diagnosed in the presence of impairments in social interaction and communication, and a restricted range of activities and interests. However, there is considerable variability in the behaviors of different individuals with an ASD diagnosis. The heterogeneity spans the entire range of IQ and language abilities, as well as other behavioral, communicative, and social functions. While any psychiatric condition is likely to incorporate a degree of heterogeneity, the variability in the nature and severity of behaviors observed in ASD is thought to exceed that of other disorders. The current paper aims to provide a model for future research into ASD subgroups. In doing so, we examined whether two proposed risk factors - low birth weight (LBW), and in utero exposure to selective serotonin reuptake inhibitors (SSRIs) - are associated with greater behavioral homogeneity. Using data from the Western Australian Autism Biological Registry, this study found that LBW and maternal SSRI use during pregnancy were associated with greater sleep disturbances and a greater number of gastrointestinal complaints in children with ASD, respectively. The findings from this "proof of principle" paper provide support for this "bottom-up" approach as a feasible method for creating homogenous groups.
C1 [Unwin, Lisa M.; Maybery, Murray T.; Whitehouse, Andrew J. O.] Univ Western Australia, Sch Psychol, Perth, WA 6009, Australia.
[Unwin, Lisa M.; Whitehouse, Andrew J. O.] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia.
[Wray, John A.] Princess Margaret Hosp Children, State Child Dev Ctr, Child & Adolescent Hlth Serv, Perth, WA, Australia.
RP Unwin, LM (reprint author), Univ Western Australia, Sch Psychol, M304,35 Stirling Highway, Crawley, WA 6009, Australia.
EM 20375262@student.uwa.edu.au
RI Maybery, Murray/H-5390-2014
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NR 38
TC 3
Z9 3
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 19
PY 2013
VL 7
AR 606
DI 10.3389/fnhum.2013.00606
PG 8
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 220HE
UT WOS:000324572700001
PM 24065914
ER
PT J
AU Redcay, E
Moran, JM
Mavros, PL
Tager-Flusberg, H
Gabrieli, JDE
Whitfield-Gabrieli, S
AF Redcay, Elizabeth
Moran, Joseph M.
Mavros, Penelope L.
Tager-Flusberg, Helen
Gabrieli, Johnd D. E.
Whitfield-Gabrieli, Susan
TI Intrinsic functional network organization in high-functioning
adolescents with autism spectrum disorder
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE autism; resting-state functional connectivity; default mode network;
intrinsic network organization; graph theory; functional MRI
ID RESTING HUMAN BRAIN; WHITE-MATTER; DEFAULT MODE; SENTENCE COMPREHENSION;
ASPERGER SYNDROME; SOCIAL COGNITION; STATE NETWORKS; BASE-LINE;
CONNECTIVITY; CORTEX
AB Converging theories and data suggest that atypical patterns of functional and structural connectivity are a hallmark neurobiological feature of autism. However, empirical studies of functional connectivity, or, the correlation of MRI signal between brain regions, have largely been conducted during task performance and/or focused on group differences within one network [e.g., the default mode network (DMN)]. This narrow focus on task-based connectivity and single network analyses precludes investigation of whole-brain intrinsic network organization in autism. To assess whole-brain network properties in adolescents with autism, we collected resting-state functional connectivity MRI (rs-fcMRI) data from neurotypical (NT) adolescents and adolescents with autism spectrum disorder (ASD). We used graph theory metrics on rs-fcMRI data with 34 regions of interest (i.e., nodes) that encompass four different functionally defined networks: cingulo-opercular, cerebellar, fronto-parietal, and DMN (Fair et al., 2009). Contrary to our hypotheses, network analyses revealed minimal differences between groups with one exception. Betweenness centrality, which indicates the degree to which a seed (or node) functions as a hub within and between networks, was greater for participants with autism for the right lateral parietal (RLatP) region of the DMN. Follow-up seed-based analyses demonstrated greater functional connectivity in ASD than NT groups between the RLatP seed and another region of the DMN, the anterior medial prefrontal cortex. Greater connectivity between these regions was related to lower ADOS (Autism Diagnostic Observation Schedule) scores (i.e., lower impairment) in autism. These findings do not support current theories of underconnectivity in autism, but, rather, underscore the need for future studies to systematically examine factors that can influence patterns of intrinsic connectivity such as autism severity, age, and head motion.
C1 [Redcay, Elizabeth] Univ Maryland, Dept Psychol, College Pk, MD 20742 USA.
[Moran, Joseph M.] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA.
[Moran, Joseph M.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA USA.
[Mavros, Penelope L.] MIT, Simons Ctr Social Brain, Cambridge, MA 02139 USA.
[Tager-Flusberg, Helen] Boston Univ, Dept Psychol, Boston, MA 02215 USA.
[Gabrieli, Johnd D. E.; Whitfield-Gabrieli, Susan] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA.
[Gabrieli, Johnd D. E.; Whitfield-Gabrieli, Susan] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
RP Redcay, E (reprint author), Univ Maryland, Dept Psychol, 1147 Biol Psychol Bldg, College Pk, MD 20742 USA.
EM redcay@umd.edu
FU Boston Autism Consortium; Eunice Kennedy Shriver National Institute of
Child Health and Human Development
FX We gratefully acknowledge the Boston Autism Consortium for providing
funding support for this project. We also wish to thank Dr. Charles A.
Nelson, Dr. Tal Kenet, and Dr. Robert Joseph for their contributions to
this multi-site project that made collection of these data possible,
including recruitment and assessment of participants with ASD. We also
thank Dr. Jasmin Cloutier and Daniel O'Young for assistance with data
collection and the Athinoula A. Martinos Imaging Center at the McGovern
Institute for Brain Research at MIT, particularly Dr. Christina
Triantafyllou for development of the current resting-state imaging
protocol. We also are grateful to the Eunice Kennedy Shriver National
Institute of Child Health and Human Development for a postdoctoral
fellowship to Elizabeth Redcay.
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NR 82
TC 11
Z9 11
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 19
PY 2013
VL 7
AR 573
DI 10.3389/fnhum.2013.00573
PG 11
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 220GU
UT WOS:000324571600001
PM 24062673
ER
PT J
AU De Rubeis, S
Pasciuto, E
Li, KW
Fernandez, E
Di Marino, D
Buzzi, A
Ostroff, LE
Klann, E
Zwartkruis, FJT
Komiyama, NH
Grant, SGN
Poujol, C
Choquet, D
Achsel, T
Posthuma, D
Smit, AB
Bagni, C
AF De Rubeis, Silvia
Pasciuto, Emanuela
Li, Ka Wan
Fernandez, Esperanza
Di Marino, Daniele
Buzzi, Andrea
Ostroff, Linnaea E.
Klann, Eric
Zwartkruis, Fried J. T.
Komiyama, Noboru H.
Grant, Seth G. N.
Poujol, Christel
Choquet, Daniel
Achsel, Tilmann
Posthuma, Danielle
Smit, August B.
Bagni, Claudia
TI CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to
Ensure Proper Dendritic Spine Formation
SO NEURON
LA English
DT Article
ID FRAGILE-X-SYNDROME; LOCAL PROTEIN-SYNTHESIS; MENTAL-RETARDATION;
SYNAPTIC PLASTICITY; KNOCKOUT MICE; NEUROPSYCHIATRIC DISORDERS;
INTELLECTUAL DISABILITY; HIPPOCAMPAL-NEURONS; MAMMALIAN TARGET; CRITICAL
REGION
AB The CYFIP1/SRA1 gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1 plays a dual role in two apparently unrelated processes, inhibiting local protein synthesis and favoring actin remodeling. Here, we show that brain-derived neurotrophic factor (BDNF)-driven synaptic signaling releases CYFIP1 from the translational inhibitory complex, triggering translation of target mRNAs and shifting CYFIP1 into the WAVE regulatory complex. Active Rac1 alters the CYFIP1 conformation, as demonstrated by intramolecular FRET, and is key in changing the equilibrium of the two complexes. CYFIP1 thus orchestrates the two molecular cascades, protein translation and actin polymerization, each of which is necessary for correct spine morphology in neurons. The CYFIP1 interactome reveals many interactors associated with brain disorders, opening new perspectives to define regulatory pathways shared by neurological disabilities characterized by spine dysmorphogenesis.
C1 [De Rubeis, Silvia; Pasciuto, Emanuela; Fernandez, Esperanza; Di Marino, Daniele; Buzzi, Andrea; Achsel, Tilmann; Bagni, Claudia] KULeuven, VIB Ctr Biol Dis, B-3000 Louvain, Belgium.
[De Rubeis, Silvia; Pasciuto, Emanuela; Fernandez, Esperanza; Di Marino, Daniele; Buzzi, Andrea; Achsel, Tilmann; Bagni, Claudia] KULeuven, Ctr Human Genet, B-3000 Louvain, Belgium.
[De Rubeis, Silvia; Pasciuto, Emanuela; Fernandez, Esperanza; Di Marino, Daniele; Buzzi, Andrea; Achsel, Tilmann; Bagni, Claudia] KULeuven, LIND, B-3000 Louvain, Belgium.
[Li, Ka Wan; Smit, August B.] VU Univ Med Ctr Amsterdam, Ctr Neurogen & Cognit Res, Dept Mol & Cellular Neurobiol, NL-1081 HV Amsterdam, Netherlands.
[Posthuma, Danielle] VU Univ Med Ctr Amsterdam, Ctr Neurogen & Cognit Res, Dept Funct Genom, NL-1081 HV Amsterdam, Netherlands.
[Posthuma, Danielle] VU Univ Med Ctr Amsterdam, Ctr Neurogen & Cognit Res, Dept Clin Genet, NL-1081 HV Amsterdam, Netherlands.
[Ostroff, Linnaea E.; Klann, Eric] NYU, Ctr Neural Sci, New York, NY 10003 USA.
[Zwartkruis, Fried J. T.] Univ Med Ctr Utrecht, Ctr Biomed Genet, NL-3584 CG Utrecht, Netherlands.
[Zwartkruis, Fried J. T.] Univ Med Ctr Utrecht, Canc Genom Ctr, NL-3584 CG Utrecht, Netherlands.
[Komiyama, Noboru H.; Grant, Seth G. N.] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh EH16 4SB, Midlothian, Scotland.
[Komiyama, Noboru H.; Grant, Seth G. N.] Univ Edinburgh, Ctr Neuroregenerat, Edinburgh EH16 4SB, Midlothian, Scotland.
[Poujol, Christel] CNRS, Bordeaux Imaging Ctr, UMS 3420, F-33000 Bordeaux, France.
[Poujol, Christel] Univ Bordeaux, UMS 3420, F-33077 Bordeaux, France.
[Choquet, Daniel] CNRS, Interdisciplinary Inst Neurosci, IINS, UMR 5297, F-33000 Bordeaux, France.
[Choquet, Daniel] Univ Bordeaux, UMR 5297, F-33077 Bordeaux, France.
[Posthuma, Danielle] Erasmus Univ, Sophia Child Hosp, Dept Child & Adolescent Psychiat, Med Ctr, NL-3000 CB Rotterdam, Netherlands.
[Bagni, Claudia] Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy.
RP Bagni, C (reprint author), KULeuven, VIB Ctr Biol Dis, B-3000 Louvain, Belgium.
EM claudia.bagni@cme.vib-kuleuven.be
FU Associazione Italiana Sindrome X Fragile; Fonds Wetenschappelijk
Onderzoek (FWO) [FWO G.0705.11]; FWO; FWO [FWO G.0705.11];
Intra-European Marie Curie Fellowship FP7; Queen Elisabeth Foundation
(Belgium); CARIPLO; VIB; Telethon [GGP10150]; FP7 GENCODYS; EU-FP7
"EUROSPIN"; Wellcome Trust; Center for Medical Systems Biology (CMSB);
[HEALTH-2009-2.1.2-1 EU-FP7 "SynSys"]
FX We thank Ilaria Napoli and Tiziana Girardi for preliminary data. We are
grateful to Evita Mohr and Joachim Kremerskothen for the PABP1 and
SYNCRIP antibodies. We are grateful to Elien Theuns, Jonathan Royaert,
Karin Jonkers, Ingeborg Beheydt, and Roel van der Schors for technical
help and to Bing Yen for viral production. We are thankful to Paul
Woolley, Carolina Barillas, and Giovanni Chillemi for comments on the
manuscript and to Sebastian Munck, coordinator of LiMoNe, for his
advice. S.D.R. was supported by the Associazione Italiana Sindrome X
Fragile and by a Fonds Wetenschappelijk Onderzoek (FWO) grant to C.B.
(FWO G.0705.11); E.P. was supported by an FWO (aspirant fellowship);
D.D.M was supported by an FWO grant to C.B. (FWO G.0705.11); E.F. was
supported by an Intra-European Marie Curie Fellowship FP7. We are
indebted to the Schizophrenia subgroup of the Psychiatric Genetics
Consortium for providing access to the results of their meta-analysis.
This work was supported by grants from the following agencies: Queen
Elisabeth Foundation (Belgium), CARIPLO, FWO (FWO G.0705.11), VIB, and
Telethon (GGP10150) to C.B.; HEALTH-2009-2.1.2-1 EU-FP7 "SynSys" to
A.B.S., S.G.N.G., and C.B.; FP7 GENCODYS and EU-FP7 "EUROSPIN" to A.B.S.
and S.G.N.G.; Wellcome Trust to S.G.N.G.; and the Center for Medical
Systems Biology (CMSB) to A.B.S. Nikon microscope used in this study was
acquired through a Hercules Type 1 AKUL/09/037 to Wim Annaert. We are
very grateful to Eef Lemmens for administrative support.
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NR 78
TC 23
Z9 23
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD SEP 18
PY 2013
VL 79
IS 6
BP 1169
EP 1182
DI 10.1016/j.neuron.2013.06.039
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA 298NC
UT WOS:000330329600014
PM 24050404
ER
PT J
AU St Pourcain, B
Whitehouse, AJO
Ang, WQ
Warrington, NM
Glessner, JT
Wang, K
Timpson, NJ
Evans, DM
Kemp, JP
Ring, SM
McArdle, WL
Golding, J
Hakonarson, H
Pennell, CE
Smith, GD
AF St Pourcain, Beate
Whitehouse, Andrew J. O.
Ang, Wei Q.
Warrington, Nicole M.
Glessner, Joseph T.
Wang, Kai
Timpson, Nicholas J.
Evans, David M.
Kemp, John P.
Ring, Susan M.
McArdle, Wendy L.
Golding, Jean
Hakonarson, Hakon
Pennell, Craig E.
Smith, George Davey
TI Common variation contributes to the genetic architecture of social
communication traits
SO MOLECULAR AUTISM
LA English
DT Article
DE ALSPAC; RAINE; Autistic trait; GWAS; Social communication; Association
ID GENOME-WIDE ASSOCIATION; AUTISM SPECTRUM DISORDERS; GENERAL-POPULATION;
PRAGMATIC LANGUAGE; HEAD CIRCUMFERENCE; LOCUS ANALYSIS; VARIANTS;
HERITABILITY; RISK; IMPAIRMENT
AB Background: Social communication difficulties represent an autistic trait that is highly heritable and persistent during the course of development. However, little is known about the underlying genetic architecture of this phenotype.
Methods: We performed a genome-wide association study on parent-reported social communication problems using items of the children's communication checklist (age 10 to 11 years) studying single and/or joint marker effects. Analyses were conducted in a large UK population-based birth cohort (Avon Longitudinal Study of Parents and their Children, ALSPAC, N = 5,584) and followed-up within a sample of children with comparable measures from Western Australia (RAINE, N = 1364).
Results: Two of our seven independent top signals (P-discovery <1.0E-05) were replicated (0.009 < P-replication <= 0.02) within RAINE and suggested evidence for association at 6p22.1 (rs9257616, meta-P = 2.5E-07) and 14q22.1 (rs2352908, meta-P = 1.1E-06). The signal at 6p22.1 was identified within the olfactory receptor gene cluster within the broader major histocompatibility complex (MHC) region. The strongest candidate locus within this genomic area was TRIM27. This gene encodes an ubiquitin E3 ligase, which is an interaction partner of methyl-CpG-binding domain (MBD) proteins, such as MBD3 and MBD4, and rare protein-coding mutations within MBD3 and MBD4 have been linked to autism. The signal at 14q22.1 was found within a gene-poor region.
Single-variant findings were complemented by estimations of the narrow-sense heritability in ALSPAC suggesting that approximately a fifth of the phenotypic variance in social communication traits is accounted for by joint additive effects of genotyped single nucleotide polymorphisms throughout the genome (h(2)(SE) = 0.18(0.066), P = 0.0027).
Conclusion: Overall, our study provides both joint and single-SNP-based evidence for the contribution of common polymorphisms to variation in social communication phenotypes.
C1 [St Pourcain, Beate; Timpson, Nicholas J.; Evans, David M.; Kemp, John P.; Smith, George Davey] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England.
[St Pourcain, Beate] Univ Bristol, Sch Oral & Dent Sci, Bristol, Avon, England.
[St Pourcain, Beate] Univ Bristol, Sch Expt Psychol, Bristol, Avon, England.
[Whitehouse, Andrew J. O.] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia.
[Whitehouse, Andrew J. O.] Univ Western Australia, Sch Psychol, Perth, WA 6009, Australia.
[Ang, Wei Q.; Warrington, Nicole M.; Pennell, Craig E.] Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia.
[Glessner, Joseph T.; Hakonarson, Hakon] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Wang, Kai] Univ So Calif, Zilkha Neurogenet Inst, Los Angeles, CA USA.
[Wang, Kai] Univ So Calif, Dept Psychiat, Los Angeles, CA USA.
[Timpson, Nicholas J.; Evans, David M.; Kemp, John P.; Ring, Susan M.; McArdle, Wendy L.; Golding, Jean; Smith, George Davey] Univ Bristol, Sch Social & Community Med, Bristol BS8 2BN, Avon, England.
RP St Pourcain, B (reprint author), Univ Bristol, MRC Integrat Epidemiol Unit, Oakfield House, Bristol BS8 2BN, Avon, England.
EM Beate.StPourcain@bristol.ac.uk
RI Warrington, Nicole/P-4868-2014
OI Warrington, Nicole/0000-0003-4195-775X
FU ALSPAC: The UK Medical Research Council; Wellcome Trust [092731,
WT083431MA]; University of Bristol; Autism Speaks [7132]; Medical
Research Council [MRC G0800582]; National Health and Medical Research
Council (NHMRC); University of Western Australia (UWA); Curtin
University; UWA Faculty of Medicine, Dentistry and Health Sciences;
RAINE Medical Research Foundation; Telethon Institute for Child Health
Research; Women's and Infants Research Foundation; NHMRC [572613,
1004065]
FX ALSPAC: The UK Medical Research Council and the Wellcome Trust (092731),
and the University of Bristol provided core support for ALSPAC, and
Autism Speaks (7132) provided support for the analysis of autistic-trait
related data. DME is supported by a Medical Research Council New
Investigator Award (MRC G0800582). JPK is funded by a Wellcome Trust
four-year PhD studentship (WT083431MA). We are extremely grateful to all
the families who took part in the ALSPAC study, the midwives for their
help in recruiting them, and the whole ALSPAC team, which includes
interviewers, computer and laboratory technicians, clerical workers,
research scientists, volunteers, managers, receptionist and nurses. We
thank the Sample Logistics and Genotyping Facilities at the Wellcome
Trust Sanger Institute and also 23andMe for generating the ALSPAC
genome-wide data.RAINE: The authors would like to acknowledge the
National Health and Medical Research Council (NHMRC) for their long term
contribution to funding the study over the last 20 years. Core
Management of the RAINE study has been funded by the University of
Western Australia (UWA), Curtin University, the UWA Faculty of Medicine,
Dentistry and Health Sciences, the RAINE Medical Research Foundation,
the Telethon Institute for Child Health Research, and the Women's and
Infants Research Foundation. DNA collection and genotyping was funded by
the NHMRC (572613). AJOW is funded by Career Development Fellowships
from the NHMRC (1004065). The authors are extremely grateful to all of
the families who took part in this study and the whole RAINE Study team,
which includes the Cohort Manager, Data Manager and data collection
team.
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NR 63
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD SEP 18
PY 2013
VL 4
AR 34
DI 10.1186/2040-2392-4-34
PG 12
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254XX
UT WOS:000327204200001
PM 24047820
ER
PT J
AU Davis, JM
Keeney, JG
Sikela, JM
Hepburn, S
AF Davis, Jonathan M.
Keeney, Jonathon G.
Sikela, James M.
Hepburn, Susan
TI Mode of Genetic Inheritance Modifies the Association of Head
Circumference and Autism-Related Symptoms: A Cross-Sectional Study
SO PLOS ONE
LA English
DT Article
ID SPECTRUM DISORDERS; 1ST YEAR; CHILDREN; GROWTH; UNDERCONNECTIVITY;
ABNORMALITIES; CONNECTIVITY; CORTEX; LIFE; SYNCHRONIZATION
AB Background: Frequently individuals with autism spectrum disorder (ASD) have been noted with a larger head circumference (HC) than their typical developing peers. Biologic hypotheses suggest that an overly rapid brain growth leads to the core symptoms of ASD by impairing connectivity. Literature is divided however where deleterious, protective and null associations of HC with ASD symptoms in individuals with ASD have been found.
Method: Individuals (n = 1,416) from the Autism Genetic Resource Exchange with ASD were examined for associations of HC with ASD like symptoms. Mixed models controlling for sex, age, race/ethnicity, simplex/multiplex status and accounting for correlations between siblings were used. Interactions by simplex/multiplex were explored. Adjustments for height in a sub-population with available data were explored as well.
Results: A Significant interaction term (p = 0.03) suggested that the effect of HC was dependent on whether the individual was simplex or multiplex. In simplex individuals at mean age (8.9 years) 1 cm increase in head circumference was associated with a 24% increase in the odds of a high social diagnostic score from the Autism Diagnostic Interview - Revised (odds ratio = 1.24, p = 0.01). There was no association in multiplex individuals. Additionally, individuals classified with a non-verbal IQ <70 were 90% simplex and had a significantly increased head circumference (0.7 cm p = 0.03) relative to a mid-range nonverbal IQ group. Interestingly, children classified with a >110 non-verbal IQ also had an increased HC (0.4 cm p = 0.04), relative to a mid-range non-verbal IQ group, and were 90% multiplex. HC effects do not appear to be confounded by height, however, larger samples with height information are needed.
Conclusion: The potential link between brain growth and autism like symptoms is complex and could depend on specific etiologies. Further investigations accounting for a likely mode of inheritance will help identify an ASD subtype related to HC.
C1 [Davis, Jonathan M.; Keeney, Jonathon G.; Sikela, James M.] Univ Colorado, Dept Biochem & Mol Genet, Human Med Genet Program, Aurora, CO 80045 USA.
[Davis, Jonathan M.; Keeney, Jonathon G.; Sikela, James M.] Univ Colorado, Dept Biochem & Mol Genet, Neurosci Program, Aurora, CO USA.
[Hepburn, Susan] Univ Colorado, Dept Psychiat, Aurora, CO USA.
[Hepburn, Susan] Univ Colorado, Dept Pediat, Aurora, CO USA.
RP Davis, JM (reprint author), Univ Colorado, Dept Biochem & Mol Genet, Human Med Genet Program, Denver Anschutz Med Campus, Aurora, CO 80045 USA.
EM Jonathan.Davis@UCDenver.edu
FU National Institute of Mental Health [1U24MH081810]; [5RO1 MH081203-04
NIMH]; [5RO1AA011853-13 NIAAA]
FX This research was funded in part by 5RO1 MH081203-04 NIMH, and funding
received was also in part from 5RO1AA011853-13 NIAAA. No additional
external funding was received for this study. The Autism Genetic
Resource Exchange is a program of Autism Speaks and is supported, in
part, by grant 1U24MH081810 from the National Institute of Mental Health
to Clara M. Lajonchere (PI). The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
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NR 47
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 18
PY 2013
VL 8
IS 9
AR e74940
DI 10.1371/journal.pone.0074940
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 221YD
UT WOS:000324695900088
PM 24058641
ER
PT J
AU Kuwabara, H
Yamasue, H
Koike, S
Inoue, H
Kawakubo, Y
Kuroda, M
Takano, Y
Iwashiro, N
Natsubori, T
Aoki, Y
Kano, Y
Kasai, K
AF Kuwabara, Hitoshi
Yamasue, Hidenori
Koike, Shinsuke
Inoue, Hideyuki
Kawakubo, Yuki
Kuroda, Miho
Takano, Yosuke
Iwashiro, Norichika
Natsubori, Tatsunobu
Aoki, Yuta
Kano, Yukiko
Kasai, Kiyoto
TI Altered Metabolites in the Plasma of Autism Spectrum Disorder: A
Capillary Electrophoresis Time-of-Flight Mass Spectroscopy Study
SO PLOS ONE
LA English
DT Article
ID MITOCHONDRIAL DYSFUNCTION; ANTIOXIDANT DEFENSES; ALZHEIMERS-DISEASE;
JAPANESE VERSION; OXIDATIVE DAMAGE; NITRIC-OXIDE; CE-TOFMS;
SCHIZOPHRENIA; METABOLOMICS; ASSOCIATION
AB Clinical diagnosis and severity of autism spectrum disorders (ASD) are determined by trained clinicians based on clinical evaluations of observed behaviors. As such, this approach is inevitably dependent on the expertise and subjective assessment of those administering the clinical evaluations. There is a need to identify objective biological markers associated with diagnosis or clinical severity of the disorder. To identify novel candidate metabolites as potential biomarkers for ASD, the current study applied capillary electrophoresis time-of-flight mass spectroscopy (CE-TOFMS) for high-throughput profiling of metabolite levels in the plasma of 25 psychotropic-naive adult males with high-functioning ASD and 28 age-matched typically-developed control subjects. Ten ASD participants and ten age-matched controls were assigned in the first exploration set, while 15 ASD participants and 18 controls were included in the second replication set. By CE-TOFMS analysis, a total of 143 metabolites were detected in the plasma of the first set. Of these, 17 metabolites showed significantly different relative areas between the ASD participants and the controls (p<0.05). Of the 17 metabolites, we consistently found that the ASD participants had significantly high plasma levels of arginine (p = 0.024) and taurine (p = 0.018), and significantly low levels of 5-oxoproline (p<0.001) and lactic acid (p = 0.031) compared with the controls in the second sample set. Further confirmatory analysis using quantification of absolute metabolite concentrations supported the robustness of high arginine (p = 0.001) and low lactic acid (p = 0.003) in the combined sample (n = 53). The present study identified deviated plasma metabolite levels associated with oxidative stress and mitochondrial dysfunction in individuals with ASD.
C1 [Kuwabara, Hitoshi; Kawakubo, Yuki; Kuroda, Miho; Kano, Yukiko] Univ Tokyo, Grad Sch Med, Dept Child Neuropsychiat, Bunkyo Ku, Tokyo 113, Japan.
[Yamasue, Hidenori; Koike, Shinsuke; Inoue, Hideyuki; Takano, Yosuke; Iwashiro, Norichika; Natsubori, Tatsunobu; Aoki, Yuta; Kasai, Kiyoto] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 113, Japan.
[Yamasue, Hidenori] Japan Sci & Technol Agcy, CREST, Chiyoda Ku, Tokyo 1028666, Japan.
[Koike, Shinsuke] Univ Tokyo, Off Mental Hlth Support, Div Counseling & Support, Bunkyo Ku, Tokyo 113, Japan.
[Kuroda, Miho] Shukutoku Univ, Fac Integrated Human & Social Welf, Dept Psychol, Chiba, Japan.
RP Yamasue, H (reprint author), Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 113, Japan.
EM yamasue-tky@umin.ac.jp
FU CREST; Japan Science and Technology Agency; Development of biomarker
candidates for social behavior
FX A part of this study was supported by CREST, Japan Science and
Technology Agency, and the "Development of biomarker candidates for
social behavior'' carried out under the Strategic Research Program for
Brain Sciences by the Ministry of Education, Culture, Sports, Science
and Technology of Japan. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript. to funding.
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NR 59
TC 4
Z9 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 18
PY 2013
VL 8
IS 9
AR e73814
DI 10.1371/journal.pone.0073814
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 221YD
UT WOS:000324695900023
PM 24058493
ER
PT J
AU Stoner, AM
Anderson, SE
Buckley, TJ
AF Stoner, Alexis M.
Anderson, Sarah E.
Buckley, Timothy J.
TI Ambient Air Toxics and Asthma Prevalence among a Representative Sample
of US Kindergarten-Age Children
SO PLOS ONE
LA English
DT Article
ID VOLATILE ORGANIC-COMPOUNDS; AUTISM SPECTRUM DISORDERS; ENVIRONMENTAL
JUSTICE; PUBLIC-HEALTH; CANCER-RISK; POLLUTION; EXPOSURE; POLLUTANTS;
COHORT; CITY
AB Background: Criteria pollutants have been associated with exacerbation of children's asthma, but the role of air toxics in relation to asthma is less clear. Our objective was to evaluate whether exposure to outdoor air toxics in early childhood increased asthma risk or severity.
Methods: Air toxics exposure was estimated using the 2002 National Air toxics Assessment (NATA) and linked to longitudinal data (n=6950) from a representative sample of US children born in 2001 and followed through kindergarten-age in the Early Child Longitudinal Study - Birth Cohort (ECLS-B).
Results: Overall, 17.7% of 5.5 year-olds had ever been told by a healthcare professional they had asthma, and 6.8% had been hospitalized or visited an emergency room for an asthma attack. Higher rates of asthma were observed among boys (20.1%), low-income (24.8%), and non-Hispanic black children (30.0%) (p <= 0.05). Air toxics exposure was greater for minority race/ethnicity (p<0.0001), low income (p<0.0001), non-rural area (p<0.001). Across all analyses, greater air toxics exposure, as represented by total NATA respiratory hazard index, or when limited to respiratory hazard index from onroad mobile sources or diesel PM, was not associated with a greater prevalence of asthma or hospitalizations (p trend >0.05). In adjusted logistic regression models, children exposed to the highest respiratory hazard index were not more likely to have asthma compared to those exposed to the lowest respiratory hazard index of total, onroad sources, or diesel PM.
Conclusions: Early childhood exposure to outdoor air toxics in a national sample has not previously been studied relative to children's asthma. Within the constraints of the study, we found no evidence that early childhood exposure to outdoor air toxics increased risk for asthma. As has been previously reported, it is evident that there are environmental justice and disparity concerns for exposure to air toxics and asthma prevalence in US children.
C1 [Stoner, Alexis M.; Buckley, Timothy J.] Ohio State Univ, Coll Publ Hlth, Div Environm Hlth Sci, Columbus, OH 43210 USA.
[Anderson, Sarah E.] Ohio State Univ, Coll Publ Hlth, Div Epidemiol, Columbus, OH 43210 USA.
RP Buckley, TJ (reprint author), US EPA, Durham, NC USA.
EM Buckley.Timothy@epa.gov
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NR 41
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 18
PY 2013
VL 8
IS 9
DI 10.1371/journal.pone.0075176
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 221YD
UT WOS:000324695900099
PM 24058662
ER
PT J
AU Selemon, LD
Friedman, HR
AF Selemon, L. D.
Friedman, H. R.
TI MOTOR STEREOTYPIES AND COGNITIVE PERSEVERATION IN NON-HUMAN PRIMATES
EXPOSED TO EARLY GESTATIONAL IRRADIATION
SO NEUROSCIENCE
LA English
DT Article
DE behavior; neurodevelopment; cortico-striatal; dopamine; autism;
schizophrenia
ID SCHIZOPHRENIC-PATIENTS; RHESUS-MONKEYS; MORPHOMETRIC ANALYSIS;
REPETITIVE BEHAVIORS; AUTISTIC-CHILDREN; PREFRONTAL CORTEX; NEURONAL
DENSITY; ETIOLOGY; ABNORMALITIES; DISORDERS
AB A number of psychiatric illnesses have been associated with prenatal disturbance of brain development, including autism, attention deficit hyperactivity disorder, and schizophrenia. Individuals afflicted with these disorders exhibit both repetitive motor and cognitive behavior. The potential role that environmental insult to the developing brain may play in generating these aberrant behaviors is unclear. Here we examine the behavioral consequences of an early gestational insult in the non-human primate. Rhesus macaques were exposed to x-irradiation during the first trimester of development to disrupt neurogenesis. The behavior of five fetally irradiated monkeys (FIMs) and five control monkeys (CONs) was observed as they matured from juvenile (1.5 years) to adult ages (4-5 years). Home-cage behavior was indistinguishable in the two groups. In the testing cage, circling was prevalent in both groups at juvenile ages, persisting to adulthood in three of the five FIMs. One FIM executed a ritualized motor sequence marked by semi-circling and undulating head movements. Seven macaques (4 FIMs, 3 CONs) were tested on a spatial Delayed Alternation (DA) task as adults. Perseverative errors and non-perseverative errors were recorded in early stages of the testing, at the 0 delay interval. While performing DA, FIMs made more errors of perseveration than CONs yet the number of total errors committed did not differ between groups. The presence of motor stereotypies and cognitive perseveration in fetally irradiated non-human primates suggests that environmental insult to the embryonic brain may contribute to repetitive motor and cognitive behaviors in neuropsychiatric diseases. Published by Elsevier Ltd. on behalf of IBRO.
C1 [Selemon, L. D.; Friedman, H. R.] Yale Univ, Dept Neurobiol, Sch Med, New Haven, CT 06520 USA.
RP Friedman, HR (reprint author), Yale Univ, Dept Neurobiol, Sch Med, POB 208001, New Haven, CT 06520 USA.
EM ldselemon@aol.com; hrfried-man@gmail.com
FU National Institutes of Health [MH59329]; Washington University Silvio
Conte Center [MH071616]
FX Acknowledgments We thank Heidi Voegeli for behavioral observation and
videography of the monkeys at juvenile ages. This work was supported by
National Institutes of Health grant MH59329 (L.D.S.) and the Washington
University Silvio Conte Center grant MH071616 (John G. Csemansky, M.D.,
Program Director).
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NR 71
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD SEP 17
PY 2013
VL 248
BP 213
EP 224
DI 10.1016/j.neuroscience.2013.06.006
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA 299UV
UT WOS:000330422100020
PM 23769911
ER
PT J
AU Oristaglio, J
West, SH
Ghaffari, M
Lech, MS
Verma, BR
Harvey, JA
Welsh, JP
Malone, RP
AF Oristaglio, J.
West, S. Hyman
Ghaffari, M.
Lech, M. S.
Verma, B. R.
Harvey, J. A.
Welsh, J. P.
Malone, R. P.
TI CHILDREN WITH AUTISM SPECTRUM DISORDERS SHOW ABNORMAL CONDITIONED
RESPONSE TIMING ON DELAY, BUT NOT TRACE, EYEBLINK CONDITIONING
SO NEUROSCIENCE
LA English
DT Article
DE autism; eyeblink conditioning; timing; cerebellum
ID NICTITATING-MEMBRANE RESPONSE; MEDIAL PREFRONTAL CORTEX; FETAL ALCOHOL
SYNDROME; EYELID RESPONSES; CEREBELLAR CORTEX; PURKINJE-CELLS; IMPAIRED
DELAY; LESIONS; DEFICITS; RABBIT
AB Children with autism spectrum disorder (ASD) and age-matched typically-developing (TD) peers were tested on two forms of eyeblink conditioning (EBC), a Pavlovian associative learning paradigm where subjects learn to execute an appropriately-timed eyeblink in response to a previously neutral conditioning stimulus (CS). One version of the task, trace EBC, interposes a stimulus-free interval between the presentation of the CS and the unconditioned stimulus (US), a puff of air to the eye which causes the subjects to blink. In delay EBC, the CS overlaps in time with the delivery of the US, usually with both stimuli terminating simultaneously. ASD children performed normally during trace EBC, exhibiting no differences from TD subjects with regard to the learning rate or the timing of the conditioned response. However, when subsequently tested on delay EBC, subjects with ASD displayed abnormally-timed conditioned eye blinks that began earlier and peaked sooner than those of TD subjects, consistent with previous findings. The results suggest an impaired ability of children with ASD to properly time conditioned eye blinks which appears to be specific to delay EBC. We suggest that this deficit may reflect a dysfunction of the cerebellar cortex in which increases in the intensity or duration of sensory input can temporarily disrupt the accuracy of motor timing over short temporal intervals. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Oristaglio, J.; Harvey, J. A.] Drexel Univ, Coll Med, Dept Physiol & Pharmacol, Philadelphia, PA 19102 USA.
[West, S. Hyman; Ghaffari, M.; Lech, M. S.; Verma, B. R.; Malone, R. P.] Drexel Univ, Coll Med, Dept Psychiat, Philadelphia, PA 19102 USA.
[Welsh, J. P.] Seattle Childrens Res Inst, Ctr Integrat Brain Res, Seattle, WA USA.
[Welsh, J. P.] Seattle Childrens Res Inst, Dept Pediat, Seattle, WA USA.
[Welsh, J. P.] Univ Washington, Seattle, WA 98195 USA.
RP Oristaglio, J (reprint author), Drexel Univ, Coll Med, Dept Physiol & Pharmacol, New Coll Bldg,Room 8215,245 North 15th St, Philadelphia, PA 19102 USA.
EM joristag@drexelmed.edu
FU National Institute of Mental Health [R21 MH084219]; National Institute
of Neurological Disorders and Stroke [R01 NS31224-19]
FX This study was supported by National Institute of Mental Health grant
R21 MH084219 to R.P.M. J.P.W. was supported by National Institute of
Neurological Disorders and Stroke grant R01 NS31224-19. We sadly
acknowledge the passing of Professors Harvey and Malone during the
course of this study. We thank Alicia Fuscellaro for assistance with
data tabulation and experimental protocols, and Mark Shiber at the
Drexel Machine shop for technical assistance with experimental hardware.
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NR 91
TC 6
Z9 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD SEP 17
PY 2013
VL 248
BP 708
EP 718
DI 10.1016/j.neuroscience.2013.06.007
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 299UV
UT WOS:000330422100064
PM 23769889
ER
PT J
AU Dinwiddie, DL
Soden, SE
Saunders, CJ
Miller, NA
Farrow, EG
Smith, LD
Kingsmore, SF
AF Dinwiddie, Darrell L.
Soden, Sarah E.
Saunders, Carol J.
Miller, Neil A.
Farrow, Emily G.
Smith, Laurie D.
Kingsmore, Stephen F.
TI De novo frameshift mutation in ASXL3 in a patient with global
developmental delay, microcephaly, and craniofacial anomalies
SO BMC MEDICAL GENOMICS
LA English
DT Article
DE ASXL3; Bohring-Opitz syndrome; Global developmental delay; Microcephaly;
Craniofacial anomalies; de novo frameshift; Exome sequencing
ID BOHRING-OPITZ SYNDROME; UNDIAGNOSED DISEASES; GENETIC-VARIATION;
SCHIZOPHRENIA; DISORDERS; GERMLINE; PATTERNS; SPECTRUM; GENOME
AB Background: Currently, diagnosis of affected individuals with rare genetic disorders can be lengthy and costly, resulting in a diagnostic odyssey and in many patients a definitive molecular diagnosis is never achieved despite extensive clinical investigation. The recent advent and use of genomic medicine has resulted in a paradigm shift in the clinical molecular genetics of rare diseases and has provided insight into the causes of numerous rare genetic conditions. In particular, whole exome and genome sequencing of families has been particularly useful in discovering de novo germline mutations as the cause of both rare diseases and complex disorders.
Case presentation: We present a six year old, nonverbal African American female with microcephaly, autism, global developmental delay, and metopic craniosynostosis. Exome sequencing of the patient and her two parents revealed a heterozygous two base pair de novo deletion, c.1897_1898delCA, p.Gln633ValfsX13 in ASXL3, predicted to result in a frameshift at codon 633 with substitution of a valine for a glutamine and introduction of a premature stop codon.
Conclusions: We provide additional evidence that, truncating and frameshifting mutations in the ASXL3 gene are the cause of a newly recognized disorder characterized by severe global developmental delay, short stature, microcephaly, and craniofacial anomalies. Furthermore, we expand the knowledge about disease causing mutations and the genotype-phenotype relationships in ASXL3 and provide evidence that rare, nonsynonymous, damaging mutations are not associated with developmental delay or microcephaly.
C1 [Dinwiddie, Darrell L.; Soden, Sarah E.; Saunders, Carol J.; Miller, Neil A.; Farrow, Emily G.; Smith, Laurie D.; Kingsmore, Stephen F.] Childrens Mercy Hosp, Ctr Pediat Genom Med, Kansas City, MO 64108 USA.
[Dinwiddie, Darrell L.; Soden, Sarah E.; Saunders, Carol J.; Miller, Neil A.; Farrow, Emily G.; Smith, Laurie D.; Kingsmore, Stephen F.] Childrens Mercy Hosp, Dept Pediat, Kansas City, MO 64108 USA.
[Dinwiddie, Darrell L.; Saunders, Carol J.; Kingsmore, Stephen F.] Childrens Mercy Hosp, Dept Pathol, Kansas City, MO 64108 USA.
[Dinwiddie, Darrell L.; Soden, Sarah E.; Saunders, Carol J.; Farrow, Emily G.; Smith, Laurie D.; Kingsmore, Stephen F.] Univ Missouri, Sch Med, Kansas City, MO 64110 USA.
[Dinwiddie, Darrell L.] Univ New Mexico, Dept Pediat, Hlth Sci Ctr, Albuquerque, NM 87131 USA.
[Dinwiddie, Darrell L.] Univ New Mexico, Clin Translat Sci Ctr, Albuquerque, NM 87131 USA.
[Dinwiddie, Darrell L.] Univ New Mexico, Albuquerque, NM 87131 USA.
RP Dinwiddie, DL (reprint author), Childrens Mercy Hosp, Ctr Pediat Genom Med, Kansas City, MO 64108 USA.
EM dldinwiddie@salud.unm.edu
FU Marion Merrell Dow Foundation; Patton Trust; WT Kemper Foundation;
Children's Mercy Hospital
FX This work was funded by the Marion Merrell Dow Foundation, the Patton
Trust, the WT Kemper Foundation, and the Children's Mercy Hospital.
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NR 25
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1755-8794
J9 BMC MED GENOMICS
JI BMC Med. Genomics
PD SEP 17
PY 2013
VL 6
AR 32
DI 10.1186/1755-8794-6-32
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 235EO
UT WOS:000325699400001
PM 24044690
ER
PT J
AU Bagga, JS
D'Antonio, LA
AF Bagga, Joetsaroop S.
D'Antonio, Lawrence A.
TI Role of conserved cis-regulatory elements in the post-transcriptional
regulation of the human MECP2 gene involved in autism
SO HUMAN GENOMICS
LA English
DT Article
DE G-quadruplex; Post-transcriptional regulation; MECP2; MicroRNAs; AU-rich
elements; Autism
ID G-QUADRUPLEX STRUCTURES; AU-RICH TRANSCRIPTOME; RNA G-QUADRUPLEX;
MESSENGER-RNA; RETT-SYNDROME; G-QUARTET; ALTERNATIVE POLYADENYLATION;
TRANSLATION INITIATION; SPLICING ENHANCER; BINDING PROTEIN
AB Background: The MECP2 gene codes for methyl CpG binding protein 2 which regulates activities of other genes in the early development of the brain. Mutations in this gene have been associated with Rett syndrome, a form of autism. The purpose of this study was to investigate the role of evolutionarily conserved cis-elements in regulating the post-transcriptional expression of the MECP2 gene and to explore their possible correlations with a mutation that is known to cause mental retardation.
Results: A bioinformatics approach was used to map evolutionarily conserved cis-regulatory elements in the transcribed regions of the human MECP2 gene and its mammalian orthologs. Cis-regulatory motifs including G-quadruplexes, microRNA target sites, and AU-rich elements have gained significant importance because of their role in key biological processes and as therapeutic targets. We discovered in the 5'-UTR (untranslated region) of MECP2 mRNA a highly conserved G-quadruplex which overlapped a known deletion in Rett syndrome patients with decreased levels of MeCP2 protein. We believe that this 5'-UTR G-quadruplex could be involved in regulating MECP2 translation. We mapped additional evolutionarily conserved G-quadruplexes, microRNA target sites, and AU-rich elements in the key sections of both untranslated regions. Our studies suggest the regulation of translation, mRNA turnover, and development-related alternative MECP2 polyadenylation, putatively involving interactions of conserved cis-regulatory elements with their respective trans factors and complex interactions among the trans factors themselves. We discovered highly conserved G-quadruplex motifs that were more prevalent near alternative splice sites as compared to the constitutive sites of the MECP2 gene. We also identified a pair of overlapping G-quadruplexes at an alternative 5' splice site that could potentially regulate alternative splicing in a negative as well as a positive way in the MECP2 pre-mRNAs.
Conclusions: A Rett syndrome mutation with decreased protein expression was found to be associated with a conserved G-quadruplex. Our studies suggest that MECP2 post-transcriptional gene expression could be regulated by several evolutionarily conserved cis-elements like G-quadruplex motifs, microRNA target sites, and AU-rich elements. This phylogenetic analysis has provided some interesting and valuable insights into the regulation of the MECP2 gene involved in autism.
C1 [Bagga, Joetsaroop S.] John P Stevens High Sch, Edison, NJ 08820 USA.
[D'Antonio, Lawrence A.] Ramapo Coll, Mahwah, NJ 07430 USA.
[Bagga, Joetsaroop S.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA.
RP D'Antonio, LA (reprint author), Ramapo Coll, 505 Ramapo Valley Rd, Mahwah, NJ 07430 USA.
EM ldant@ramapo.edu
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NR 76
TC 4
Z9 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1473-9542
J9 HUM GENOMICS
JI Hum. Genomics
PD SEP 16
PY 2013
VL 7
AR 19
DI 10.1186/1479-7364-7-19
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA 230JB
UT WOS:000325333400001
PM 24040966
ER
PT J
AU Wang, J
Barstein, J
Ethridge, LE
Mosconi, MW
Takarae, Y
Sweeney, JA
AF Wang, Jun
Barstein, Jamie
Ethridge, Lauren E.
Mosconi, Matthew W.
Takarae, Yukari
Sweeney, John A.
TI Resting state EEG abnormalities in autism spectrum disorders
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Review
DE Autism; Resting-state; EEG; Electroencephalography
ID PERVASIVE DEVELOPMENTAL DISORDERS; DEFICIT-HYPERACTIVITY DISORDER;
FUNCTIONAL MAGNETIC-RESONANCE; LANGUAGE-ASSOCIATION CORTEX; DEFAULT MODE
NETWORK; FRAGILE-X-SYNDROME; TO-NOISE RATIO; BRAIN ACTIVITY;
WHITE-MATTER; ALPHA OSCILLATIONS
AB Autism spectrum disorders (ASD) are a group of complex and heterogeneous developmental disorders involving multiple neural system dysfunctions. In an effort to understand neurophysiological substrates, identify etiopathophysiologically distinct subgroups of patients, and track outcomes of novel treatments with translational biomarkers, EEG (electroencephalography) studies offer a promising research strategy in ASD. Resting-state EEG studies of ASD suggest a U-shaped profile of electrophysiological power alterations, with excessive power in low-frequency and high-frequency bands, abnormal functional connectivity, and enhanced power in the left hemisphere of the brain. In this review, we provide a summary of recent findings, discuss limitations in available research that may contribute to inconsistencies in the literature, and offer suggestions for future research in this area for advancing the understanding of ASD.
C1 [Wang, Jun; Barstein, Jamie; Ethridge, Lauren E.; Mosconi, Matthew W.; Takarae, Yukari; Sweeney, John A.] Univ Texas Southwestern, Dept Psychiat, Dallas, TX 75390 USA.
[Mosconi, Matthew W.; Sweeney, John A.] Univ Texas Southwestern, Dept Pediat, Dallas, TX USA.
[Sweeney, John A.] Bond Univ, Ctr Autism Spectrum Disorders, Gold Coast, Australia.
RP Wang, J (reprint author), Univ Texas Southwestern, Dept Psychiat, Dallas, TX 75390 USA.
EM jun.wang@utsouthwestern.edu
FU NIMH Autism Center of Excellence [1P50HD055751-01, K23MH092696,
K01MH087720]; Department of the Army [AR100276]; Autism Speaks
FX This study was funded by the NIMH Autism Center of Excellence
1P50HD055751-01, K23MH092696, K01MH087720, Department of the Army award
AR100276, and Autism Speaks.
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NR 167
TC 6
Z9 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD SEP 16
PY 2013
VL 5
AR 24
DI 10.1186/1866-1955-5-24
PG 14
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 221VL
UT WOS:000324688000001
PM 24040879
ER
PT J
AU Giancardo, L
Sona, D
Huang, HP
Sannino, S
Manago, F
Scheggia, D
Papaleo, F
Murino, V
AF Giancardo, Luca
Sona, Diego
Huang, Huiping
Sannino, Sara
Manago, Francesca
Scheggia, Diego
Papaleo, Francesco
Murino, Vittorio
TI Automatic Visual Tracking and Social Behaviour Analysis with Multiple
Mice
SO PLOS ONE
LA English
DT Article
ID AUTISM; RECOGNITION; DROSOPHILA; RODENTS; DENSE
AB Social interactions are made of complex behavioural actions that might be found in all mammalians, including humans and rodents. Recently, mouse models are increasingly being used in preclinical research to understand the biological basis of social-related pathologies or abnormalities. However, reliable and flexible automatic systems able to precisely quantify social behavioural interactions of multiple mice are still missing. Here, we present a system built on two components. A module able to accurately track the position of multiple interacting mice from videos, regardless of their fur colour or light settings, and a module that automatically characterise social and non-social behaviours. The behavioural analysis is obtained by deriving a new set of specialised spatio-temporal features from the tracker output. These features are further employed by a learning-by-example classifier, which predicts for each frame and for each mouse in the cage one of the behaviours learnt from the examples given by the experimenters. The system is validated on an extensive set of experimental trials involving multiple mice in an open arena. In a first evaluation we compare the classifier output with the independent evaluation of two human graders, obtaining comparable results. Then, we show the applicability of our technique to multiple mice settings, using up to four interacting mice. The system is also compared with a solution recently proposed in the literature that, similarly to us, addresses the problem with a learning-by-examples approach. Finally, we further validated our automatic system to differentiate between C57B/6J (a commonly used reference inbred strain) and BTBR T+tf/J (a mouse model for autism spectrum disorders). Overall, these data demonstrate the validity and effectiveness of this new machine learning system in the detection of social and non-social behaviours in multiple (>2) interacting mice, and its versatility to deal with different experimental settings and scenarios.
C1 [Giancardo, Luca; Sona, Diego; Huang, Huiping; Sannino, Sara; Manago, Francesca; Scheggia, Diego; Papaleo, Francesco; Murino, Vittorio] Ist Italiano Tecnol, Genoa, Italy.
[Papaleo, Francesco] Univ Padua, Dipartimento Sci Farmaco, Padua, Italy.
RP Giancardo, L (reprint author), Ist Italiano Tecnol, Genoa, Italy.
EM luca.giancardo@iit.it; francesco.papaleo@iit.it
RI Sona, Diego/A-9667-2014
FU Istituto Italiano di Tecnologia; Marie Curie FP7-Reintegration-Grant
[268247]
FX This research was supported by the Istituto Italiano di Tecnologia and
by the Marie Curie FP7-Reintegration-Grant No268247. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
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NR 45
TC 3
Z9 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 16
PY 2013
VL 8
IS 9
AR e74557
DI 10.1371/journal.pone.0074557
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 219GJ
UT WOS:000324494000128
PM 24066146
ER
PT J
AU Koshimizu, E
Miyatake, S
Okamoto, N
Nakashima, M
Tsurusaki, Y
Miyake, N
Saitsu, H
Matsumoto, N
AF Koshimizu, Eriko
Miyatake, Satoko
Okamoto, Nobuhiko
Nakashima, Mitsuko
Tsurusaki, Yoshinori
Miyake, Noriko
Saitsu, Hirotomo
Matsumoto, Naomichi
TI Performance Comparison of Bench-Top Next Generation Sequencers Using
Microdroplet PCR-Based Enrichment for Targeted Sequencing in Patients
with Autism Spectrum Disorder
SO PLOS ONE
LA English
DT Article
ID DE-NOVO MUTATIONS; VARIANTS; PLATFORMS; SEIZURES; DISEASE; REPAIR;
STRAND; GENE; TWIN
AB Next-generation sequencing (NGS) combined with enrichment of target genes enables highly efficient and low-cost sequencing of multiple genes for genetic diseases. The aim of this study was to validate the accuracy and sensitivity of our method for comprehensive mutation detection in autism spectrum disorder (ASD). We assessed the performance of the bench-top Ion Torrent PGM and Illumina MiSeq platforms as optimized solutions for mutation detection, using microdroplet PCR-based enrichment of 62 ASD associated genes. Ten patients with known mutations were sequenced using NGS to validate the sensitivity of our method. The overall read quality was better with MiSeq, largely because of the increased indel-related error associated with PGM. The sensitivity of SNV detection was similar between the two platforms, suggesting they are both suitable for SNV detection in the human genome. Next, we used these methods to analyze 28 patients with ASD, and identified 22 novel variants in genes associated with ASD, with one mutation detected by MiSeq only. Thus, our results support the combination of target gene enrichment and NGS as a valuable molecular method for investigating rare variants in ASD.
C1 [Koshimizu, Eriko; Miyatake, Satoko; Nakashima, Mitsuko; Tsurusaki, Yoshinori; Miyake, Noriko; Saitsu, Hirotomo; Matsumoto, Naomichi] Yokohama City Univ, Dept Human Genet, Grad Sch Med, Yokohama, Kanagawa 232, Japan.
[Okamoto, Nobuhiko] Osaka Med Ctr, Dept Med Genet, Osaka, Japan.
[Okamoto, Nobuhiko] Res Inst Maternal & Child Hlth, Osaka, Japan.
RP Matsumoto, N (reprint author), Yokohama City Univ, Dept Human Genet, Grad Sch Med, Yokohama, Kanagawa 232, Japan.
EM naomat@yokohama-cu.ac.jp
FU Ministry of Health, Labour and Welfare; Japan Science and Technology
Agency; Ministry of Education, Culture, Sports, Science and Technology
of Japan; Japan Society for the Promotion of Science; Takeda Science
Foundation
FX Research grants from the Ministry of Health, Labour and Welfare: the
Japan Science and Technology Agency: and the Strategic Research Program
for Brain Sciences, Grant-in-Aid for Scientific Research on Innovative
Areas (Transcription cycle) from the Ministry of Education, Culture,
Sports, Science and Technology of Japan, Grant-in-Aid for Scientific
Research from Japan Society for the Promotion of Science, Grant-in-Aid
for Young Scientist from Japan Society for the Promotion of Science, and
Grant from the Takeda Science Foundation. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILL SUMM, V61, P1
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NR 31
TC 2
Z9 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 16
PY 2013
VL 8
IS 9
AR e74167
DI 10.1371/journal.pone.0074167
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 219GJ
UT WOS:000324494000096
PM 24066114
ER
PT J
AU Sappok, T
Budczies, J
Bolte, S
Dziobek, I
Dosen, A
Diefenbacher, A
AF Sappok, Tanja
Budczies, Jan
Bolte, Sven
Dziobek, Isabel
Dosen, Anton
Diefenbacher, Albert
TI Emotional Development in Adults with Autism and Intellectual
Disabilities: A Retrospective, Clinical Analysis
SO PLOS ONE
LA English
DT Article
ID DIAGNOSTIC OBSERVATION SCHEDULE; SPECTRUM DISORDERS; ADAPTIVE-BEHAVIOR;
MENTAL-HEALTH; PSYCHIATRIC-ASSESSMENT; FUNCTIONING AUTISM;
RETARDED-CHILDREN; SOCIAL-BEHAVIOR; ABILITIES; INDIVIDUALS
AB Individuals with intellectual disability (ID) are at risk for additional autism spectrum disorders (ASD). A large amount of research reveals deficits in emotion-related processes that are relevant to social cognition in ASD. However, studies on the structure and level of emotional development (ED) assessing emotional maturity according to the normative trajectory in typically developing children are scares. The level of ED can be evaluated by the 'Scheme of Appraisal of Emotional Development' (SAED), a semi-structured interview with a close caregiver. The SAED assesses the level of emotional developmental based on a five stage system in 10 domains, for example, 'interaction with peers' or 'object permanence', which are conducive to the overall emotional developmental level. This study examined the ED as measured by the SAED in 289 adults (mean age: 36 years) with ID with and without additional ASD. A lower level in ED was observed in ASD/ID combined that corresponded to the ED of typically developing children aged 1.5-3 years versus an ED with a corresponding age of 3-7 years in ID individuals without ASD. Moreover, distinct strengths in 'object permanence', and weaknesses in 'interaction', 'verbal communication', 'experience of self', 'affect differentiation', 'anxiety', and 'handling of material objects' led to a characteristic pattern of ED in ASD. SAED domains with highest discriminative power between ID individuals with and without ASD (5/10) were used to predict ASD group membership. The classification using a selection of SAED domains revealed a sensitivity of 77.5% and a specificity of 76.4%. ASD risk increased 2.7-fold with every SAED level. The recognition of delayed and uneven pattern of ED contributes to our understanding of the emotion-related impairments in adults with ID and ASD these individuals. Assessment of intra-individual ED could add value to the standard diagnostic procedures in ID, a population at risk for underdiagnosed ASD.
C1 [Sappok, Tanja; Diefenbacher, Albert] Evangel Krankenhaus Konigin Elisabeth Herzberge, Dept Psychiat, Berlin, Germany.
[Budczies, Jan] Charite, Inst Pathol, Berlin, Germany.
[Bolte, Sven] Karolinska Inst KIND, Dept Womens & Childrens Hlth, Ctr Neurodev Disorders, Stockholm, Sweden.
[Dziobek, Isabel] Free Univ Berlin, Cluster Excellence Languages Emot, Berlin, Germany.
[Dosen, Anton] Radboud Univ Nijmegen, Univ Hosp, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands.
RP Sappok, T (reprint author), Evangel Krankenhaus Konigin Elisabeth Herzberge, Dept Psychiat, Berlin, Germany.
EM t.sappok@keh-berlin.de
FU von Bodelschwinghsche Stiftungen Bethel; Swedish Research Council
[523-2009-7054]
FX The study was funded by the "von Bodelschwinghsche Stiftungen Bethel.''
Sven Bolte was supported by the Swedish Research Council (grant nr.
523-2009-7054). The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
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NR 114
TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 16
PY 2013
VL 8
IS 9
AR e74036
DI 10.1371/journal.pone.0074036
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 219GJ
UT WOS:000324494000074
PM 24066092
ER
PT J
AU Kezurer, N
Galron, D
Golan, HM
AF Kezurer, N.
Galron, D.
Golan, H. M.
TI Increased susceptibility to mild neonatal stress in MTHFR deficient mice
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Sociability; Anxiety; C1-metabolism; Early-life-stress
ID CHINESE HAN POPULATION; MATERNAL-CARE; GLUCOCORTICOID-RECEPTORS; DNA
METHYLATION; AUTISM; RAT; SCHIZOPHRENIA; POLYMORPHISM; BEHAVIORS;
RELEVANT
AB Early life stress is shown to have a life-span outcome on human and animal behavior, increasing the risk for psychopathology. The gene methylenetetrahydrofolate reductase (MTHFR), which encodes for a key enzyme in one carbon metabolism, shows a high prevalence of polymorphism in patients with developmental disorders. Here we examined the hypothesis that MTHFR deficiency results in an increased susceptibility of the developing brain to mild neonatal stress (NS). Mild NS failed to alter corticosterone levels in young and adult Wt mice. However, an elevated level of corticosterone was found in the MTHFR deficient-NS female, exemplifying enhanced sensitivity to NS. Behavioral phenotyping of Wt and MTHFR deficient mice provides evidence that the effect of mild NS may be amplified by the MTHFR deficient genotype. Distinct behavioral characteristics were altered in male and female mice. In general, three patterns of influence on mice behavior were observed: (1) an additive suppressive effect of NS and MTHFR deficiency on exploration and activity was evident in females; (2) stress related parameters were significantly sensitive to genotype in females, presenting an interaction between genotype and sex; (3) various aspects of behavior in a social setting were modified preferably in males by genotype, NS and the interaction between the two, while females exhibited a smaller effect that was restricted to NS with no genotype effect. Overall, our results support an interaction between mild NS, the MTHFR genotype and sex. We suggest using this animal model to study the molecular mechanism linking these two risk factors and their involvement in neurodevelopmental disorders such as schizophrenia and autism. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Kezurer, N.; Golan, H. M.] Ben Gurion Univ Negev, Dept Physiol & Cell Biol, IL-84105 Beer Sheva, Israel.
[Kezurer, N.; Golan, H. M.] Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, IL-84105 Beer Sheva, Israel.
[Galron, D.] Soroka Med Ctr, Genet Inst, IL-84101 Beer Sheva, Israel.
RP Golan, HM (reprint author), Ben Gurion Univ Negev, Dept Physiol & Cell Biol, Fac Hlth Sci, IL-84105 Beer Sheva, Israel.
EM nowagolan@gmail.com; daliagalron1@gmail.com; havag@bgu.ac.il
RI GOLAN, HAVA/F-2121-2012
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NR 36
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD SEP 15
PY 2013
VL 253
BP 240
EP 252
DI 10.1016/j.bbr.2013.07.037
PG 13
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 222GZ
UT WOS:000324720500032
PM 23896051
ER
PT J
AU Shi, LL
Chang, X
Zhang, PL
Coba, MP
Lu, WG
Wang, K
AF Shi, Lingling
Chang, Xiao
Zhang, Peilin
Coba, Marcelo P.
Lu, Wange
Wang, Kai
TI The functional genetic link of NLGN4X knockdown and neurodevelopment in
neural stem cells
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID AUTISM; NEUROLIGINS; EXPRESSION; NEUREXINS; DISEASES; TRANSCRIPTOME;
MUTATIONS; INSIGHTS
AB Genetic mutations in NLGN4X (neuroligin 4), including point mutations and copy number variants (CNVs), have been associated with susceptibility to autism spectrum disorders (ASDs). However, it is unclear how mutations in NLGN4X result in neurodevelopmental defects. Here, we used neural stem cells (NSCs) as in vitro models to explore the impacts of NLGN4X knockdown on neurodevelopment. Using two shRNAmir-based vectors targeting NLGN4X and one control shRNAmir vector, we modulated NLGN4X expression and differentiated these NSCs into mature neurons. We monitored the neurodevelopmental process at Weeks 0, 0.5, 1, 2, 4 and 6, based on morphological analysis and whole-genome gene expression profiling. At the cellular level, in NSCs with NLGN4X knockdown, we observed increasingly delayed neuronal development and compromised neurite formation, starting from Week 2 through Week 6 post differentiation. At the molecular level, we identified multiple pathways, such as neurogenesis, neuron differentiation and muscle development, which are increasingly disturbed in cells with NLGN4X knockdown. Notably, several postsynaptic genes, including DLG4, NLGN1 and NLGN3, also have decreased expression. Based on in vitro models, NLGN4X knockdown directly impacts neurodevelopmental process during the formation of neurons and their connections. Our functional genomics study highlights the utility of NSCs models in understanding the functional roles of CNVs in affecting neurodevelopment and conferring susceptibility to neurodevelopmental diseases.
C1 [Shi, Lingling; Chang, Xiao; Coba, Marcelo P.; Wang, Kai] Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA.
[Zhang, Peilin; Lu, Wange] Univ So Calif, Keck Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90089 USA.
[Lu, Wange] Univ So Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90089 USA.
[Coba, Marcelo P.; Wang, Kai] Univ So Calif, Keck Sch Med, Dept Psychiat, Los Angeles, CA 90033 USA.
[Wang, Kai] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
RP Wang, K (reprint author), Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA.
EM kaiwang@usc.edu
FU Zilkha Neurogenetic Institute; NIH [P30 MH08977, R01 HG006465]
FX The study is supported by start-up funds from the Zilkha Neurogenetic
Institute to K. W., and in part by NIH grant P30 MH08977 (PI: Levitt)
and R01 HG006465 (PI: K.W.).
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NR 47
TC 3
Z9 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD SEP 15
PY 2013
VL 22
IS 18
BP 3749
EP 3760
DI 10.1093/hmg/ddt226
PG 12
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 207FD
UT WOS:000323582000011
PM 23710042
ER
PT J
AU Drobnjak, I
Cruz, G
Alexander, DC
AF Drobnjak, Ivana
Cruz, Gastao
Alexander, Daniel C.
TI Optimising oscillating waveform-shape for pore size sensitivity in
diffusion-weighted MR
SO MICROPOROUS AND MESOPOROUS MATERIALS
LA English
DT Article; Proceedings Paper
CT 11th International Bologna Conference on Magnetic Resonance in Porous
Media (MRPM)
CY SEP 09-13, 2012
CL Guildford, ENGLAND
SP Adv Magnet Resonance Ltd, Anvendt Teknologi AS, Bruker BioSpin GmbH, Chevron, HeidelbergCement GmbH, Inst Phys, BRSG Magnet Resonance Grp, Magritek Ltd, MR Solut Ltd, Oxford Instruments, Schlumberger Doll Res, Schlumberger Gould Res, Stelar Srl, Univ Bologna, Univ Surrey, Fac Engn & Phys Sci (Int Comm)
HO Univ Surrey
DE Pore size; Diffusion MR; Oscillating gradients; Axon radius
ID MICROSTRUCTURE SENSITIVITY; RESTRICTED DIFFUSION; GRADIENT; NMR; WATER;
AUTISM; TISSUE
AB Optimising the shape of a generalised gradient waveform (GEN) in diffusion-weighted MR has been shown to, in theory, greatly increase sensitivity to pore size. The broad class of optimised shapes takes simple oscillatory forms. To speed up convergence of the optimisation, improve computation times and make the waveforms more practical, here we explore various oscillatory waveforms constructed from trapezoidal and sinusoidal shapes and compare their performance with the optimised GEN waveform. The oscillating waveforms are optimised to maximise sensitivity to parameters, such as axon radius, intra-cellular volume fraction and diffusion constants, of a simple white matter model. Simulation experiments find that all oscillating waveforms we tried perform significantly better than the original generalised waveform due to the improved convergence of the optimisation. Differences among the oscillating shapes however are very small and although a truncated sinusoidal waveform consistently gives the lowest cost function, no significant difference in the estimated model parameters was found. Therefore the simplest choice, i.e. the trapezoidal parametrisation, seems sufficient for most practical purposes. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Drobnjak, Ivana; Cruz, Gastao; Alexander, Daniel C.] UCL, Dept Comp Sci, Ctr Med Image Comp, London WC1E 6BT, England.
RP Drobnjak, I (reprint author), UCL, Dept Comp Sci, Ctr Med Image Comp, Gower St, London WC1E 6BT, England.
EM i.drobnjak@ucl.ac.uk
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NR 17
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1387-1811
J9 MICROPOR MESOPOR MAT
JI Microporous Mesoporous Mat.
PD SEP 15
PY 2013
VL 178
SI SI
BP 11
EP 14
DI 10.1016/j.micromeso.2013.03.004
PG 4
WC Chemistry, Applied; Chemistry, Physical; Nanoscience & Nanotechnology;
Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 191PZ
UT WOS:000322426400004
ER
PT J
AU Mameza, MG
Dvoretskova, E
Bamann, M
Honck, HH
Guler, T
Boeckers, TM
Schoen, M
Verpelli, C
Sala, C
Barsukov, I
Dityatev, A
Kreienkamp, HJ
AF Mameza, Marie Germaine
Dvoretskova, Elena
Bamann, Margarete
Hoenck, Hans-Hinrich
Gueler, Tuerkan
Boeckers, Tobias M.
Schoen, Michael
Verpelli, Chiara
Sala, Carlo
Barsukov, Igor
Dityatev, Alexander
Kreienkamp, Hans-Juergen
TI SHANK3 Gene Mutations Associated with Autism Facilitate Ligand Binding
to the Shank3 Ankyrin Repeat Region
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID POSTSYNAPTIC DENSITY PROTEINS; ARCHITECTURAL FRAMEWORK; SCAFFOLDING
PROTEINS; SYNAPTIC PROTEINS; SPECTRUM DISORDER; FAMILY; SHARPIN;
EXPRESSION; BEHAVIORS; COMPLEX
AB Shank/ProSAP proteins are major scaffold proteins of the postsynaptic density; mutations in the human SHANK3 gene are associated with intellectual disability or autism spectrum disorders. We have analyzed the functional relevance of several SHANK3 missense mutations affecting the N-terminal portion of the protein by expression of wild-type and mutant Shank3 in cultured neurons and by binding assays in heterologous cells. Postsynaptic targeting of recombinant Shank3 was unaltered. In electrophysiological experiments, both wild-type and L68P mutant forms of Shank3 were equally effective in restoring synaptic function after knockdown of endogenous Shank3. We observed that several mutations affected binding to interaction partners of the Shank3 ankyrin repeat region. One of these mutations, L68P, improved binding to both ligands. Leu-68 is located N-terminal to the ankyrin repeats, in a highly conserved region that we identify here as a novel domain termed the Shank/ProSAP N-terminal (SPN) domain. We show that the SPN domain interacts with the ankyrin repeats in an intramolecular manner, thereby restricting access of either Sharpin or alpha-fodrin. The L68P mutation disrupts this blockade, thus exposing the Shank3 ankyrin repeat region to its ligands. Our data identify a new type of regulation of Shank proteins and suggest that mutations in the SHANK3 gene do not necessarily induce a loss of function, but may represent a gain of function with respect to specific interaction partners.
C1 [Mameza, Marie Germaine; Bamann, Margarete; Hoenck, Hans-Hinrich; Gueler, Tuerkan; Kreienkamp, Hans-Juergen] Univ Krankenhaus Hamburg Eppendorf, Inst Humangenet, D-20246 Hamburg, Germany.
[Dvoretskova, Elena; Dityatev, Alexander] Ist Italiano Tecnol, Dept Neurosci & Brain Technol, I-16163 Genoa, Italy.
[Boeckers, Tobias M.; Schoen, Michael] Univ Ulm, Inst Anat & Cell Biol, D-89069 Ulm, Germany.
[Verpelli, Chiara; Sala, Carlo] Univ Milan, Consiglio Nazl Ric, Inst Neurosci, I-20129 Milan, Italy.
[Verpelli, Chiara; Sala, Carlo] Univ Milan, Dept Med Biotechnol & Translat Med, I-20129 Milan, Italy.
[Sala, Carlo] Neurol Inst Fdn Carlo Besta, Dept Neuromuscular Dis & Neuroimmunol, I-20133 Milan, Italy.
[Barsukov, Igor] Univ Liverpool, Inst Integrat Biol, Liverpool L69 3BX, Merseyside, England.
[Dityatev, Alexander] Deutsch Zentrum Neurodegenerat Erkrankungen, Mol Neuroplast Grp, D-39120 Magdeburg, Germany.
RP Kreienkamp, HJ (reprint author), Univ Krankenhaus Hamburg Eppendorf, Inst Humangenet, Martinistr 52, D-20246 Hamburg, Germany.
EM Kreienkamp@uke.de
RI Sala, Carlo/A-2493-2009
OI Sala, Carlo/0000-0003-0662-9523
FU Deutsche Forschungsgemeinschaft [FOR885, IRP2, Kr1312/3-2]; Telethon
Fondazione Onlus [GGP11095]; Istituto Italiano di Tecnologia; Seed
grant; Ministry of Health in the frame of European Research Area Network
NEURON; Programma Nazionale per la Ricerca-Consiglio Nazionale delle
Ricerche Aging Program
FX This work was supported by Deutsche Forschungsgemeinschaft Grants
FOR885, IRP2, and Kr1312/3-2 (to H.-J. K.), Telethon Fondazione Onlus
Grant GGP11095 (to C. S. and A. D.), Istituto Italiano di Tecnologia (to
A. D.) and Seed grant (to C. S.), Ministry of Health in the frame of
European Research Area Network NEURON (to C. S.), and Programma
Nazionale per la Ricerca-Consiglio Nazionale delle Ricerche Aging
Program 2012-2014 (to C. S.).
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NR 39
TC 2
Z9 5
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD SEP 13
PY 2013
VL 288
IS 37
BP 26697
EP 26708
DI 10.1074/jbc.M112.424747
PG 12
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 302HM
UT WOS:000330594500035
PM 23897824
ER
PT J
AU D'Adamo, MC
Catacuzzeno, L
Di Giovanni, G
Franciolini, F
Pessia, M
AF D'Adamo, Maria Cristina
Catacuzzeno, Luigi
Di Giovanni, Giuseppe
Franciolini, Fabio
Pessia, Mauro
TI K+ channelepsy: progress in the neurobiology of potassium channels and
epilepsy
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Review
DE Potassium channels: [Kv1, Kv2, Kv3, Kv4, Kv8, Kv11(HERG) K-Ca1.1, Kv
beta 1, Kv beta 2, KChIP LGI1, Kir1-Kir7 (GIRK, K-ATP)]; temporal lobe
epilepsy; autism-epilepsy; channelopathies
ID EPISODIC ATAXIA TYPE-1; TEMPORAL-LOBE EPILEPSY; UNION-OF-PHARMACOLOGY;
ACTION-POTENTIAL REPOLARIZATION; NEOCORTICAL PYRAMIDAL NEURONS;
X-RAY-STRUCTURE; BK-CHANNEL; SEIZURE SUSCEPTIBILITY; DENTATE GYRUS;
GLIAL-CELLS
AB K+ channels are important determinants of seizure susceptibility. These membrane proteins, encoded by more than 70 genes, make the largest group of ion channels that fine-tune the electrical activity of neuronal and non-neuronal cells in the brain. Their ubiquity and extremely high genetic and functional diversity, unmatched by any other ion channel type, place K+ channels as primary targets of genetic variations or perturbations in K+-dependent homeostasis, even in the absence of a primary channel defect. It is therefore not surprising that numerous inherited or acquired K+ channels dysfunctions have been associated with several neurologic syndromes, including epilepsy, which often generate confusion in the classification of the associated diseases. Therefore, we propose to name the K+ channels defects underlying distinct epilepsies as "K+ channelepsies," and introduce a new nomenclature (e.g., Kx.y-channelepsy), following the widely used K+ channel classification, which could be also adopted to easily identify other channelopathies involving Na+ (e.g., Navx.y-phenotype), Ca2+ (e.g., Cavx.y-phenotype), and Cl-channels. Furthermore, we discuss novel genetic defects in K+ channels and associated proteins that underlie distinct epileptic phenotypes in humans, and analyze critically the recent progress in the neurobiology of this disease that has also been provided by investigations on valuable animal models of epilepsy. The abundant and varied lines of evidence discussed here strongly foster assessments for variations in genes encoding for K+ channels and associated proteins in patients with idiopathic epilepsy, provide new avenues for future investigations, and highlight these proteins as critical pharmacological targets.
C1 [D'Adamo, Maria Cristina; Pessia, Mauro] Univ Perugia, Dept Internal Med, Fac Med, Sect Human Physiol, I-06132 Perugia, Italy.
[D'Adamo, Maria Cristina; Di Giovanni, Giuseppe; Pessia, Mauro] IEMEST, Ist Euro Mediterraneo Sci & Tecnol, Palermo, Italy.
[Catacuzzeno, Luigi; Franciolini, Fabio] Univ Perugia, Dipartimento Biol Cellulare & Ambientale, I-06132 Perugia, Italy.
[Di Giovanni, Giuseppe] Univ Malta, Dept Physiol & Biochem, Msida, Malta.
RP D'Adamo, MC (reprint author), Univ Perugia, Dept Internal Med, Fac Med, Sect Human Physiol, Ple Gambuli,Edificio D Piano 1, I-06132 Perugia, Italy.
EM maria.dadamo@unipg.it; mauro.pessia@unipg.it
RI franciolini, fabio/F-9699-2014; Di Giovanni, Giuseppe/N-3047-2013;
Catacuzzeno, Luigi/M-4637-2014
OI Di Giovanni, Giuseppe/0000-0003-2006-563X;
FU Telethon [GGP11188]; Ministero della Salute [GR-2009-1580433]; COMPAGNIA
di San Paolo (Turin) "Programma Neuroscienze"; Fondazione Cassa di
Risparmio di Perugia; [MIUR-PRIN 20108WT59Y_004]
FX This work was supported by Telethon (GGP11188), Ministero della Salute
(GR-2009-1580433); MIUR-PRIN 20108WT59Y_004; COMPAGNIA di San Paolo
(Turin) "Programma Neuroscienze," and Fondazione Cassa di Risparmio di
Perugia.
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NR 208
TC 12
Z9 12
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD SEP 13
PY 2013
VL 7
AR 134
DI 10.3389/fncel.2013.00134
PG 21
WC Neurosciences
SC Neurosciences & Neurology
GA 220ID
UT WOS:000324575300001
PM 24062639
ER
PT J
AU Underwood, E
AF Underwood, Emily
TI Alarm Over Autism Test
SO SCIENCE
LA English
DT News Item
NR 0
TC 0
Z9 0
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD SEP 13
PY 2013
VL 341
IS 6151
BP 1164
EP 1167
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 215ZA
UT WOS:000324248800012
PM 24030995
ER
PT J
AU Berk, M
Williams, LJ
Jacka, FN
O'Neil, A
Pasco, JA
Moylan, S
Allen, NB
Stuart, AL
Hayley, AC
Byrne, ML
Maes, M
AF Berk, Michael
Williams, Lana J.
Jacka, Felice N.
O'Neil, Adrienne
Pasco, Julie A.
Moylan, Steven
Allen, Nicholas B.
Stuart, Amanda L.
Hayley, Amie C.
Byrne, Michelle L.
Maes, Michael
TI So depression is an inflammatory disease, but where does the
inflammation come from?
SO BMC MEDICINE
LA English
DT Article
DE Depression; Inflammation; Cytokines; Diet; Obesity; Exercise; Smoking;
Vitamin D; Dental cares; Sleep; Atopic; Gut; Oxidative stress
ID POSTTRAUMATIC-STRESS-DISORDER; C-REACTIVE PROTEIN;
NECROSIS-FACTOR-ALPHA; MUSCLE-DERIVED INTERLEUKIN-6; POLYUNSATURATED
FATTY-ACIDS; VITAMIN-D SUPPLEMENTATION; CORONARY-HEART-DISEASE;
MIDDLE-AGED WOMEN; MAJOR DEPRESSION; PERIODONTAL-DISEASE
AB Background: We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to neuroprogression in the disorder. The obvious question this poses is 'what is the source of this chronic low-grade inflammation?'
Discussion: This review explores the role of inflammation and oxidative and nitrosative stress as possible mediators of known environmental risk factors in depression, and discusses potential implications of these findings. A range of factors appear to increase the risk for the development of depression, and seem to be associated with systemic inflammation; these include psychosocial stressors, poor diet, physical inactivity, obesity, smoking, altered gut permeability, atopy, dental cares, sleep and vitamin D deficiency.
Summary: The identification of known sources of inflammation provides support for inflammation as a mediating pathway to both risk and neuroprogression in depression. Critically, most of these factors are plastic, and potentially amenable to therapeutic and preventative interventions. Most, but not all, of the above mentioned sources of inflammation may play a role in other psychiatric disorders, such as bipolar disorder, schizophrenia, autism and post-traumatic stress disorder.
C1 [Berk, Michael; Williams, Lana J.; Jacka, Felice N.; O'Neil, Adrienne; Pasco, Julie A.; Moylan, Steven; Stuart, Amanda L.; Hayley, Amie C.; Maes, Michael] Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, Geelong, Vic 3217, Australia.
[Berk, Michael; Williams, Lana J.; Jacka, Felice N.] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia.
[Berk, Michael] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
[Berk, Michael] Orygen Youth Hlth Res Ctr, Parkville, Vic, Australia.
[O'Neil, Adrienne] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia.
[Pasco, Julie A.] Univ Melbourne, Dept Med, NorthWest Acad Ctr, St Albans, Vic, Australia.
[Allen, Nicholas B.; Byrne, Michelle L.] Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic 3052, Australia.
[Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
RP Berk, M (reprint author), Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, Geelong, Vic 3217, Australia.
EM mikebe@barwonhealth.org.au
RI nakham, kwanphat/F-4661-2014
FU NIH; Cooperative Research Centre; Simons Autism Foundation; Cancer
Council of Victoria; Stanley Medical Research Foundation; MBF; NHMRC;
Beyond Blue; Rotary Health; Geelong Medical Research Foundation; Bristol
Myers Squibb; Eli Lilly; Glaxo SmithKline; Organon; Novartis; Mayne
Pharma; Servier; Brain and Behaviour Research Institute; National Health
and Medical Research Council (NHMRC); Australian Rotary Health; Ian
Potter Foundation; University of Melbourne; NHMRC [628912];
Sanofi-Synthelabo; Janssen Cilag; Pfizer; Health Ed; Network Nutrition
FX MB has received Grant/Research Support from the NIH, Cooperative
Research Centre, Simons Autism Foundation, Cancer Council of Victoria,
Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Rotary
Health, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli
Lilly, Glaxo SmithKline, Organon, Novartis, Mayne Pharma and Servier;
has been a speaker for Astra Zeneca, Bristol Myers Squibb, Eli Lilly,
Glaxo SmithKline, Janssen Cilag, Lundbeck, Merck, Pfizer, Sanofi
Synthelabo, Servier, Solvay and Wyeth; and served as a consultant to
Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen
Cilag, Lundbeck Merck and Servier. FJ has received Grant/Research
support from the Brain and Behaviour Research Institute, the National
Health and Medical Research Council (NHMRC), Australian Rotary Health,
the Geelong Medical Research Foundation, the Ian Potter Foundation, Eli
Lilly and The University of Melbourne, and has been a paid speaker for
Sanofi-Synthelabo, Janssen Cilag, Servier, Pfizer, Health Ed, Network
Nutrition and Eli Lilly. She is currently supported by an NHMRC Training
Fellowship (#628912).
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NR 251
TC 56
Z9 56
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD SEP 12
PY 2013
VL 11
AR 200
DI 10.1186/1741-7015-11-200
PG 16
WC Medicine, General & Internal
SC General & Internal Medicine
GA 216CY
UT WOS:000324260200001
PM 24228900
ER
PT J
AU Nemeroff, CB
Weinberger, D
Rutter, M
MacMillan, HL
Bryant, RA
Wessely, S
Stein, DJ
Pariante, CM
Seemuller, F
Berk, M
Malhi, GS
Preisig, M
Brune, M
Lysaker, P
AF Nemeroff, Charles B.
Weinberger, Daniel
Rutter, Michael
MacMillan, Harriet L.
Bryant, Richard A.
Wessely, Simon
Stein, Dan J.
Pariante, Carmine M.
Seemueller, Florian
Berk, Michael
Malhi, Gin S.
Preisig, Martin
Bruene, Martin
Lysaker, Paul
TI DSM-5: a collection of psychiatrist views on the changes, controversies,
and future directions
SO BMC MEDICINE
LA English
DT Article
DE DSM-5; Psychiatry; Autism; PTSD; Mood disorders; Bipolar;
Obsessive-compulsive disorders; Depression; Schizophrenia
ID OBSESSIVE-COMPULSIVE DISORDER; POSTTRAUMATIC-STRESS-DISORDER;
RANDOMIZED-CONTROLLED-TRIAL; SKIN PICKING DISORDER; MOOD DYSREGULATION
DISORDER; CHILD-PARENT PSYCHOTHERAPY; HAIR-PULLING DISORDER; BEREAVEMENT
EXCLUSION; ANXIETY DISORDERS; HOARDING DISORDER
AB The recent release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) by the American Psychiatric Association has led to much debate. For this forum article, we asked BMC Medicine Editorial Board members who are experts in the field of psychiatry to discuss their personal views on how the changes in DSM-5 might affect clinical practice in their specific areas of psychiatric medicine. This article discusses the influence the DSM-5 may have on the diagnosis and treatment of autism, trauma-related and stressor-related disorders, obsessive-compulsive and related disorders, mood disorders (including major depression and bipolar disorders), and schizophrenia spectrum disorders.
C1 [Nemeroff, Charles B.] Univ Miami, Leonard M Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL USA.
[Weinberger, Daniel] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA.
[Weinberger, Daniel] Johns Hopkins Univ, Sch Med, Inst Med Genet, Lieber Inst Brain Dev, Baltimore, MD 21205 USA.
[Rutter, Michael] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, MRC, London, England.
[MacMillan, Harriet L.] McMaster Univ, Dept Psychiat, Offord Ctr Child Studies, Hamilton, ON, Canada.
[MacMillan, Harriet L.] McMaster Univ, Dept Behav Neurosci, Offord Ctr Child Studies, Hamilton, ON, Canada.
[MacMillan, Harriet L.] McMaster Univ, Dept Pediat, Offord Ctr Child Studies, Hamilton, ON, Canada.
[Bryant, Richard A.] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
[Wessely, Simon] Kings Coll London, Inst Psychiat, Dept Psychol Med, Weston Educ Ctr, London, England.
[Stein, Dan J.] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7925 Cape Town, South Africa.
[Stein, Dan J.] Groote Schuur Hosp, ZA-7925 Cape Town, South Africa.
[Pariante, Carmine M.] Kings Coll London, James Black Ctr, Inst Psychiat, Dept Psychol Med, London, England.
[Seemueller, Florian] Univ Munich, Dept Psychiat & Psychotherapy, D-80336 Munich, Germany.
[Berk, Michael] Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, Geelong, Vic 3220, Australia.
[Berk, Michael] Univ Melbourne, Orygen Res Ctr, Dept Psychiat, Parkville, Vic 3052, Australia.
[Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia.
[Malhi, Gin S.] Univ Sydney, Sydney Med Sch, Discipline Psychiat, Sydney, NSW 2006, Australia.
[Malhi, Gin S.] Royal N Shore Hosp, Dept Psychiat, CADE Clin, Sydney, NSW, Australia.
[Preisig, Martin] Univ Lausanne Hosp, Dept Psychiat, CH-1008 Prilly, Switzerland.
[Bruene, Martin] Ruhr Univ Bochum, Div Cognit Neuropsychiat & Psychiat Prevent Med, LWL Univ Hosp, D-44791 Bochum, Germany.
[Lysaker, Paul] Richard L Roudebush VA Med Ctr, Indianapolis, IN USA.
[Lysaker, Paul] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
RP Nemeroff, CB (reprint author), Univ Miami, Leonard M Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL USA.
EM bmcmedicineeditorial@biomedcentral.com
RI Stein, Dan/A-1752-2008
OI Stein, Dan/0000-0001-7218-7810
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NR 73
TC 12
Z9 13
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD SEP 12
PY 2013
VL 11
AR 202
DI 10.1186/1741-7015-11-202
PG 19
WC Medicine, General & Internal
SC General & Internal Medicine
GA 216CY
UT WOS:000324260200003
PM 24229007
ER
PT J
AU Wardenaar, KJ
de Jonge, P
AF Wardenaar, Klaas J.
de Jonge, Peter
TI Diagnostic heterogeneity in psychiatry: towards an empirical solution
SO BMC MEDICINE
LA English
DT Article
DE DSM-5; Heterogeneity; Data-driven techniques; Cattell's cube
ID MAJOR DEPRESSIVE DISORDER; AUTISM SPECTRUM DISORDER; LATENT CLASS
ANALYSIS; COMPONENT ANALYSIS; DSM-5 CRITERIA; PSYCHOPATHOLOGY;
CLASSIFICATION; TRAJECTORIES; COMORBIDITY; MODELS
AB The launch of the 5th version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) has sparked a debate about the current approach to psychiatric classification. The most basic and enduring problem of the DSM is that its classifications are heterogeneous clinical descriptions rather than valid diagnoses, which hampers scientific progress. Therefore, more homogeneous evidence-based diagnostic entities should be developed. To this end, data-driven techniques, such as latent class-and factor analyses, have already been widely applied. However, these techniques are insufficient to account for all relevant levels of heterogeneity, among real-life individuals. There is heterogeneity across persons (p: for example, subgroups), across symptoms (s:for example, symptom dimensions) and over time (t:for example, course-trajectories) and these cannot be regarded separately. Psychiatry should upgrade to techniques that can analyze multi-mode (p-by-s-by-t) data and can incorporate all of these levels at the same time to identify optimal homogeneous subgroups (for example, groups with similar profiles/connectivity of symptomatology and similar course). For these purposes, Multimode Principal Component Analysis and (Mixture)-Graphical Modeling may be promising techniques.
C1 [Wardenaar, Klaas J.; de Jonge, Peter] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, NL-9713 GZ Groningen, Netherlands.
RP de Jonge, P (reprint author), Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Hanzepl 1, NL-9713 GZ Groningen, Netherlands.
EM peter.de.jonge@umcg.nl
RI de Jonge, peter/L-6395-2013; Wardenaar, Klaas/E-2985-2013
OI de Jonge, peter/0000-0002-0866-6929;
FU VICI grant from Netherlands Research Foundation (NWO-ZonMW) [91812607]
FX PdJ and KJW are supported by a VICI grant (no: 91812607) from the
Netherlands Research Foundation (NWO-ZonMW).
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NR 20
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD SEP 12
PY 2013
VL 11
AR 201
DI 10.1186/1741-7015-11-201
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 216CY
UT WOS:000324260200002
PM 24228940
ER
PT J
AU Dolen, G
Darvishzadeh, A
Huang, KW
Malenka, RC
AF Doelen, Guel
Darvishzadeh, Ayeh
Huang, Kee Wui
Malenka, Robert C.
TI Social reward requires coordinated activity of nucleus accumbens
oxytocin and serotonin
SO NATURE
LA English
DT Article
ID MEDIUM SPINY NEURONS; HYPOTHALAMO-NEUROHYPOPHYSEAL SYSTEM; BASAL
GANGLIA; CONCURRENT ACTIVATION; AFFILIATIVE BEHAVIOR; FOREBRAIN CIRCUIT;
INDIRECT PATHWAYS; ADOLESCENT MICE; GENE-EXPRESSION; RABIES VIRUS
AB Social behaviours in species as diverse as honey bees and humans promote group survival but often come at some cost to the individual. Although reinforcement of adaptive social interactions is ostensibly required for the evolutionary persistence of these behaviours, the neural mechanisms by which social reward is encoded by the brain are largely unknown. Here we demonstrate that in mice oxytocin acts as a social reinforcement signal within the nucleus accumbens core, where it elicits a presynaptically expressed long-term depression of excitatory synaptic transmission in medium spiny neurons. Although the nucleus accumbens receives oxytocin-receptor-containing inputs from several brain regions, genetic deletion of these receptors specifically from dorsal raphe nucleus, which provides serotonergic (5-hydroxytryptamine; 5-HT) innervation to the nucleus accumbens, abolishes the reinforcing properties of social interaction. Furthermore, oxytocin-induced synaptic plasticity requires activation of nucleus accumbens 5-HT1B receptors, the blockade of which prevents social reward. These results demonstrate that the rewarding properties of social interaction in mice require the coordinated activity of oxytocin and 5-HT in the nucleus accumbens, a mechanistic insight with implications for understanding the pathogenesis of social dysfunction in neuropsychiatric disorders such as autism.
C1 [Doelen, Guel; Darvishzadeh, Ayeh; Huang, Kee Wui; Malenka, Robert C.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Stanford, CA 94305 USA.
RP Malenka, RC (reprint author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, 265 Campus Dr, Stanford, CA 94305 USA.
EM malenka@stanford.edu
FU National Institutes of Health [NIH NS069375]; Simons Foundation Autism
Research Initiative; Berry Foundation
FX We thank members of the Malenka laboratory for comments; A. Andalman, W.
Xu, B. K. Lim and T. Sudhof for technical advice; and the SIM1 Animal
Care facility for husbandry support. The OT-neurophysin antibody was a
gift of H. Gainer. OTR-Venus reporter mice were a gift of L. J. Young.
D1-TdTomato BAC transgenic mice were provided by N. Calakos. The rabies
virus complementary DNA plasmid and viral component-expressing plasmids
were gifts from K. Conzelmann and I. Wickersham. HHK-B19G cells were a
gift from E. Callaway. AAVs were produced by the Stanford NGVVC
(supported by National Institutes of Health grant NIH NS069375). The
AAV-DJ helper plasmid was a gift from M. Kay. This work was supported by
funding from the Simons Foundation Autism Research Initiative (R. C.
M.), N. I. H. (R. C. M.), and a Berry Foundation Postdoctoral Fellowship
(G.D.)
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NR 47
TC 55
Z9 55
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD SEP 12
PY 2013
VL 501
IS 7466
BP 179
EP +
DI 10.1038/nature12518
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 215XR
UT WOS:000324244900032
PM 24025838
ER
PT J
AU Allen, AS
Berkovic, SF
Cossette, P
Delanty, N
Dlugos, D
Eichler, EE
Epstein, MP
Glauser, T
Goldstein, DB
Han, YJ
Heinzen, EL
Hitomi, Y
Howell, KB
Johnson, MR
Kuzniecky, R
Lowenstein, DH
Lu, YF
Madou, MRZ
Marson, AG
Mefford, HC
Nieh, SE
O'Brien, TJ
Ottman, R
Petrovski, S
Poduri, A
Ruzzo, EK
Scheffer, IE
Sherr, EH
Yuskaitis, CJ
Abou-Khalil, B
Alldredge, BK
Bautista, JF
Berkovic, SF
Boro, A
Cascino, GD
Consalvo, D
Crumrine, P
Devinsky, O
Dlugos, D
Epstein, MP
Fiol, M
Fountain, NB
French, J
Friedman, D
Geller, EB
Glauser, T
Glynn, S
Haut, SR
Hayward, J
Helmers, SL
Joshi, S
Kanner, A
Kirsch, HE
Knowlton, RC
Kossoff, E
Kuperman, R
Kuzniecky, R
Lowenstein, DH
McGuire, SM
Motika, PV
Novotny, EJ
Ottman, R
Paolicchi, JM
Parent, JM
Park, K
Poduri, A
Scheffer, IE
Shellhaas, RA
Sherr, EH
Shih, JJ
Singh, R
Sirven, J
Smith, MC
Sullivan, J
Thio, LL
Venkat, A
Vining, EPG
Von Allmen, GK
Weisenberg, JL
Widdess-Walsh, P
Winawer, MR
AF Allen, Andrew S.
Berkovic, Samuel F.
Cossette, Patrick
Delanty, Norman
Dlugos, Dennis
Eichler, Evan E.
Epstein, Michael P.
Glauser, Tracy
Goldstein, David B.
Han, Yujun
Heinzen, Erin L.
Hitomi, Yuki
Howell, Katherine B.
Johnson, Michael R.
Kuzniecky, Ruben
Lowenstein, Daniel H.
Lu, Yi-Fan
Madou, Maura R. Z.
Marson, Anthony G.
Mefford, Heather C.
Nieh, Sahar Esmaeeli
O'Brien, Terence J.
Ottman, Ruth
Petrovski, Slave
Poduri, Annapurna
Ruzzo, Elizabeth K.
Scheffer, Ingrid E.
Sherr, Elliott H.
Yuskaitis, Christopher J.
Abou-Khalil, Bassel
Alldredge, Brian K.
Bautista, Jocelyn F.
Berkovic, Samuel F.
Boro, Alex
Cascino, Gregory D.
Consalvo, Damian
Crumrine, Patricia
Devinsky, Orrin
Dlugos, Dennis
Epstein, Michael P.
Fiol, Miguel
Fountain, Nathan B.
French, Jacqueline
Friedman, Daniel
Geller, Eric B.
Glauser, Tracy
Glynn, Simon
Haut, Sheryl R.
Hayward, Jean
Helmers, Sandra L.
Joshi, Sucheta
Kanner, Andres
Kirsch, Heidi E.
Knowlton, Robert C.
Kossoff, Erich
Kuperman, Rachel
Kuzniecky, Ruben
Lowenstein, Daniel H.
McGuire, Shannon M.
Motika, Paul V.
Novotny, Edward J.
Ottman, Ruth
Paolicchi, Juliann M.
Parent, Jack M.
Park, Kristen
Poduri, Annapurna
Scheffer, Ingrid E.
Shellhaas, Renee A.
Sherr, Elliott H.
Shih, Jerry J.
Singh, Rani
Sirven, Joseph
Smith, Michael C.
Sullivan, Joseph
Thio, Liu Lin
Venkat, Anu
Vining, Eileen P. G.
Von Allmen, Gretchen K.
Weisenberg, Judith L.
Widdess-Walsh, Peter
Winawer, Melodie R.
TI De novo mutations in epileptic encephalopathies
SO NATURE
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; INTELLECTUAL DISABILITY; MENTAL-RETARDATION;
EPILEPSIES; DISORDERS; AUTISM; SUSCEPTIBILITY; SPECTRUM; DISEASE;
PROTEIN
AB Epileptic encephalopathies are a devastating group of severe childhood epilepsy disorders for which the cause is often unknown(1). Here we report a screen for de novo mutations in patients with two classical epileptic encephalopathies: infantile spasms (n = 149) and Lennox-Gastaut syndrome (n = 115). We sequenced the exomes of 264 probands, and their parents, and confirmed 329 de novo mutations. A likelihood analysis showed a significant excess of de novo mutations in the similar to 4,000 genes that are the most intolerant to functional genetic variation in the human population (P = 2.9 x 10(-3)). Among these are GABRB3, with de novo mutations in four patients, and ALG13, with the same de novo mutation in two patients; both genes show clear statistical evidence of association with epileptic encephalopathy. Given the relevant site-specific mutation rates, the probabilities of these outcomes occurring by chance are P = 4.1 x 10(-10) and P = 7.8 x 10(-12), respectively. Other genes with de novo mutations in this cohort include CACNA1A, CHD2, FLNA, GABRA1, GRIN1, GRIN2B, HNRNPU, IQSEC2, MTOR and NEDD4L. Finally, we show that the de novo mutations observed are enriched in specific gene sets including genes regulated by the fragile X protein (P < 10(-8)), as has been reported previously for autism spectrum disorders(2).
C1 [Allen, Andrew S.] Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Duke Clin Res Inst, Durham, NC 27710 USA.
[Allen, Andrew S.] Duke Univ, Med Ctr, Ctr Human Genome Variat, Durham, NC 27710 USA.
[Berkovic, Samuel F.; Petrovski, Slave] Univ Melbourne Austin Hlth, Dept Med, Epilepsy Res Ctr, Heidelberg, Vic 3084, Australia.
[Cossette, Patrick] Univ Montreal, CHUM Hop Notre Dame Montre, Montreal, PQ H2L 4M1, Canada.
[Cossette, Patrick] CHUM Res Ctr, Montreal, PQ H2L 4M1, Canada.
[Delanty, Norman] Royal Coll Surg, Dublin 9, Ireland.
[Delanty, Norman] Beaumont Hosp, Dept Neurol, Dublin 9, Ireland.
[Dlugos, Dennis; Venkat, Anu] Univ Penn, Perelman Sch Med, Childrens Hosp Philadelphia, Dept Neurol & Pediat, Philadelphia, PA 19104 USA.
[Eichler, Evan E.] Univ Washington, Sch Med, Dept Gen Sci, Seattle, WA 98195 USA.
[Eichler, Evan E.] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA.
[Epstein, Michael P.] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA.
[Glauser, Tracy] Cincinnati Childrens Hosp Med Ctr, Div Neurol, Cincinnati, OH 45229 USA.
[Goldstein, David B.; Han, Yujun; Heinzen, Erin L.; Hitomi, Yuki; Lu, Yi-Fan; Petrovski, Slave; Ruzzo, Elizabeth K.] Duke Univ, Sch Med, Ctr Human Genome Variat, Durham, NC 27708 USA.
[Howell, Katherine B.] Royal Childrens Hosp Melbourne, Dept Neurol, Parkville, Vic 3052, Australia.
[Johnson, Michael R.] Ctr Clin Translat Div Brain Sci, London SW7 2AZ, England.
[Kuzniecky, Ruben; French, Jacqueline; Friedman, Daniel] NYU, Sch Med, Dept Neurol, Comprehens Epilepsy Ctr, New York, NY 10016 USA.
[Lowenstein, Daniel H.; Madou, Maura R. Z.; Kirsch, Heidi E.; Sullivan, Joseph] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA.
[Marson, Anthony G.] Univ Liverpool, Ctr Clin Sci, Dept Mol & Clin Pharmacol, Liverpool L9 7LJ, Merseyside, England.
[Mefford, Heather C.] Univ Washington, Div Med Genet, Dept Pediat, Seattle, WA 98115 USA.
[Nieh, Sahar Esmaeeli] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[O'Brien, Terence J.; Petrovski, Slave] Royal Melbourne Hosp, Dept Med, Parkville, Vic 3146, Australia.
[O'Brien, Terence J.; Petrovski, Slave] Royal Melbourne Hosp, Dept Neurol, Parkville, Vic 3146, Australia.
[Ottman, Ruth] Columbia Univ, Dept Epidemiol, New York, NY 10027 USA.
[Ottman, Ruth] Columbia Univ, Dept Neurol, New York, NY 10027 USA.
[Ottman, Ruth] Columbia Univ, GH Sergievsky Ctr, New York, NY 10027 USA.
[Ottman, Ruth] New York State Psychiat Inst & Hosp, Div Epidemiol, New York, NY 10032 USA.
[Poduri, Annapurna] Boston Childrens Hosp, Dept Neurol, Div Epilepsy & Clin Neurophysiol, Boston, MA 02115 USA.
[Scheffer, Ingrid E.] Univ Melbourne Austin Hlth, Dept Med, Epilepsy Res Ctr, Heidelberg, Vic 3084, Australia.
[Scheffer, Ingrid E.] Univ Melbourne, Florey Inst, Parkville, Vic 3052, Australia.
[Scheffer, Ingrid E.] Univ Melbourne, Dept Pediat, Royal Childrens Hosp, Parkville, Vic 3052, Australia.
[Sherr, Elliott H.] Univ Calif San Francisco, Pediat & Inst Human Genet, Dept Neurol, San Francisco, CA 94158 USA.
[Yuskaitis, Christopher J.] Harvard Univ, Sch Med, Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA.
[Abou-Khalil, Bassel; Paolicchi, Juliann M.] Vanderbilt Univ, Med Ctr, Dept Neurol, Nashville, TN 37232 USA.
[Alldredge, Brian K.] Univ Calif San Francisco, Sch Med, UCSF Sch Pharm, Dept Clin Pharm,Dept Neurol, San Francisco, CA 94143 USA.
[Bautista, Jocelyn F.] Cleveland Clin Neurol Inst, Cleveland Clin Lerner Coll Med & Epilepsy Ctr, Dept Neurol, Cleveland, OH 44195 USA.
[Boro, Alex] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Neurol, Bronx, NY 10467 USA.
[Cascino, Gregory D.] Mayo Clin, Div Epilepsy, Rochester, MN 55905 USA.
[Consalvo, Damian] Ramos Meji Hosp, Div Neurol, Epilepsy Ctr, RA-1221 Buenos Aires, DF, Argentina.
[Crumrine, Patricia] Univ Pittsburgh, UPMC, Med Epilepsy Program & EEG & Child Neurol, Childrens Hosp Pittsburgh,Sch Med, Pittsburgh, PA 15224 USA.
[Devinsky, Orrin] NYU, Sch Med, St Barnabas Epilepsy Ctr, New York, NY 10016 USA.
[Fiol, Miguel] Univ Minnesota, Sch Med, Epilepsy Care Ctr, Dept Neurol, Minneapolis, MN 55414 USA.
[Fountain, Nathan B.] Univ Virginia, FE Dreifuss Comprehens Epilepsy Program, Charlottesville, VA 22908 USA.
[Geller, Eric B.; Widdess-Walsh, Peter] St Barnabas Hosp, Div Neurol, Livingston, NJ 07039 USA.
[Glynn, Simon] Univ Michigan Hlth Syst, Dept Neurol, Comprehens Epilepsy Program, Ann Arbor, MI 48109 USA.
[Haut, Sheryl R.] Montefiore Med Ctr, Comprehens Epilepsy Ctr, Bronx, NY 10467 USA.
[Hayward, Jean] Kaiser Permanente Grp, Oakland, CA 94618 USA.
[Helmers, Sandra L.] Emory Univ, Sch Med, Atlanta, GA 30322 USA.
[Joshi, Sucheta] Univ Michigan, Ann Arbor, MI 48109 USA.
[Kanner, Andres; Smith, Michael C.] Rush Univ, Med Ctr, Rush Epilepsy Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.
[Kirsch, Heidi E.] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA.
[Knowlton, Robert C.] Univ Texas Houston, Sch Med, Houston, TX 77030 USA.
[Kossoff, Erich] Johns Hopkins Univ Hosp, Child Neurol Pediat Neurol Residency Program, Baltimore, MD 21287 USA.
[Kuperman, Rachel] Childrens Hosp, Epilepsy Program, Oakland, CA 94609 USA.
[Kuperman, Rachel] Res Ctr Oakland, Oakland, CA 94609 USA.
[McGuire, Shannon M.] Childrens Hosp Epilepsy Ctr New Orleans, New Orleans, LA 70118 USA.
[Motika, Paul V.] Oregon Hlth & Sci Univ, Comprehens Epilepsy Ctr, Portland, OR 97239 USA.
[Novotny, Edward J.] Univ Washington, Sch Med, Seattle Childrens Hosp, Dept Neurol, Seattle, WA 98105 USA.
[Novotny, Edward J.] Univ Washington, Sch Med, Seattle Childrens Hosp, Dept Pediat, Seattle, WA 98105 USA.
[Paolicchi, Juliann M.] Weill Cornell Med Ctr, New York, NY 10065 USA.
[Parent, Jack M.] Univ Michigan, Med Ctr, Dept Neurol & Neurosci, Grad Program, Ann Arbor, MI 49108 USA.
[Parent, Jack M.] Ann Arbor Vet Adm Healthcare Syst, Ann Arbor, MI 48105 USA.
[Park, Kristen] Univ Colorado, Childrens Hosp Colorado, Sch Med, Dept Neurol, Denver, CO 80045 USA.
Univ Colorado, Childrens Hosp Colorado, Sch Med, Dept Pediat, Denver, CO 80045 USA.
[Shellhaas, Renee A.] Univ Michigan, Ann Arbor, MI USA.
[Shih, Jerry J.] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA.
[Singh, Rani] Univ Michigan Hlth Syst, Div Pediat Neurol, Ann Arbor, MI 48109 USA.
[Sirven, Joseph] Mayo Clin, Dept Neurol, Scottsdale, AZ 85259 USA.
[Thio, Liu Lin] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
[Vining, Eileen P. G.] Dept Neurol, Baltimore, MD 21287 USA.
[Von Allmen, Gretchen K.] Univ Texas Houston, Sch Med, Div Child & Adolescent Neurol, Dept Pediat, Houston, TX 77030 USA.
[Weisenberg, Judith L.] Washington Univ, Sch Med, Div Pediat Neurol, Dept Neurol, St Louis, MO 63110 USA.
[Winawer, Melodie R.] Columbia Univ, Dept Neurol, New York, NY 10032 USA.
[Winawer, Melodie R.] Columbia Univ, GH Sergievsky Ctr, New York, NY 10032 USA.
RP Allen, AS (reprint author), Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Duke Clin Res Inst, Durham, NC 27710 USA.
RI O'Brien, Terence/L-8102-2013; Ottman, Ruth/O-2371-2013; Scheffer,
Ingrid/G-1668-2013
OI Scheffer, Ingrid/0000-0002-2311-2174
FU National Institute of Neurological Disorders and Stroke [NS053998,
NS077364, NS077274, NS077303, NS077276]; Richard Thalheimer
Philanthropic Fund; ARRA [1RC2NS070342]; NIAID [R56AI098588]; Ellison
Medical Foundation New Scholar award [AG-NS-0441-08]; SAID-Frederick,
Inc. [M11-074]; Center for HIV/AIDS Vaccine Immunology ("CHAVI") from
the National Institute of Allergy and Infectious Diseases, National
Institutes of Health [UO1AIO67854]
FX We are grateful to the patients, their families, clinical research
coordinators and referring physicians for participating in the Epilepsy
Phenome/Genome Project (EPGP) and providing the phenotype data and DNA
samples used in this study. We thank the following professional and lay
organizations for substantial assistance in publicizing EPGP and
therefore enabling us to recruit participants effectively: AED Pregnancy
Registry, American Epilepsy Society, Association of Child Neurology
Nurses, California School Nurses Organization, Child Neurology Society,
Citizens United for Research in Epilepsy, Dravet Syndrome Foundation,
Epilepsy Alliance of Orange County, Epilepsy Foundation, Epilepsy
Therapy Project, Finding a Cure for Epilepsy and Seizures, IDEA League,
InfantileSpasms.com, Lennox-Gastaut Syndrome Foundation, PatientsLikeMe,
People Against Childhood Epilepsy, PVNH Support & Awareness, and
Seizures & Epilepsy Education. We thank the EPGP Administrative Core (C.
Freyer, K. Schardein, R.N., M. S., R. Fahlstrom, M. P. H., S.
Cristofaro, R.N., B.S.N. and K. McGovern), EPGP Bioinformatics Core (G.
Nesbitt, K. McKenna, V. Mays), staff at the Coriell Institute - NINDS
Genetics Repository (C. Tarn, A. Scutti), and members of the Duke Center
for Human Genome Variation (B. Krueger, J. Bridgers, J. Keebler, H. Shin
Kim, E. Campbell, K. Cronin, L. Hong and M. McCall) for their dedication
and commitment to this work. We also thank S. Shinnar (Albert Einstein
College of Medicine) and N. Risch (University of California, San
Francisco) for valuable input into the creation of EPGP and Epi4K, and
R. Stewart, K. Gwinn and R. Corriveau from the National Institute of
Neurological Disorders and Stroke for their careful oversight and
guidance of both EPGP and Epi4K. This work was supported by grants from
the National Institute of Neurological Disorders and Stroke (The
Epilepsy Phenome/Genome Project NS053998; Epi4K Project 1-Epileptic
Encephalopathies NS077364; Epi4K-Administrative Core NS077274;
Epi4K-Sequencing, Biostatistics and Bioinformatics Core NS077303 and
Epi4K-Phenotyping and Clinical Informatics Core NS077276); Finding a
Cure for Epilepsy and Seizures; and the Richard Thalheimer Philanthropic
Fund. We would like to acknowledge the following individuals and groups
for their contribution of control samples: J. Hoover-Fong, N. Sobreira
and D. Valle; The MURDOCK Study Community Registry and Biorepository (D.
Murdock); S. Sisodiya; D. Attix; O. Chiba-Falek; V. Shashi; P. Lugar; W.
Lowe; S. Palmer; D. Marchuk; Z. Farfel, D. Lancet, E. Pras; Q. Zhao; D.
Daskalakis; R. Brown; E. Holtzman; R. Gbadegesin; M. Winn; S. Kerns; and
H. Oster. The collection of control samples was funded in part by ARRA
1RC2NS070342, NIAID R56AI098588, the Ellison Medical Foundation New
Scholar award AG-NS-0441-08, an award from SAID-Frederick, Inc.
(M11-074), and with federal funds by the Center for HIV/AIDS Vaccine
Immunology ("CHAVI") under a grant from the National Institute of
Allergy and Infectious Diseases, National Institutes of Health
(UO1AIO67854).
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NR 31
TC 149
Z9 152
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD SEP 12
PY 2013
VL 501
IS 7466
BP 217
EP +
DI 10.1038/nature12439
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 215XR
UT WOS:000324244900040
ER
PT J
AU Fernandez-Abascal, EG
Cabello, R
Fernandez-Berrocal, P
Baron-Cohen, S
AF Fernandez-Abascal, Enrique G.
Cabello, Rosario
Fernandez-Berrocal, Pablo
Baron-Cohen, Simon
TI Test-retest reliability of the 'Reading the Mind in the Eyes' test: a
one-year follow-up study
SO MOLECULAR AUTISM
LA English
DT Article
DE Reading the mind in the eyes; Reliability; Assessment; Social cognition;
Theory of mind
ID UNAFFECTED 1ST-DEGREE RELATIVES; HIGH-FUNCTIONING AUTISM;
ASPERGER-SYNDROME; SCHIZOPHRENIA-PATIENTS; SOCIAL COGNITION; FACIAL
EMOTION; NORMAL ADULTS; NEURAL BASIS; RECOGNITION; POPULATION
AB Background: The 'Reading the Mind in the Eyes' (Eyes) test is an advanced test of theory of mind. It is widely used to assess individual differences in social cognition and emotion recognition across different groups and cultures. The present study examined distributions of responses and scores on a Spanish version of the test in a non-clinical Spanish adult population, and assessed test-retest reliability over a 1-year interval.
Methods: A total of 358 undergraduates of both sexes, age 18 to 65 years, completed the Spanish version of the test twice over an interval of 1 year. The Bland-Altman method was used to calculate test-retest reliability.
Results: Distributions of responses and scores were optimal. Test-retest reliability for total score on the Eyes test was .63 (P <.01), based on the intraclass correlation coefficient. Test-retest reliability using the Bland-Altman method was fairly good.
Conclusions: This is the first study providing evidence that the Eyes test is reliable and stable over a 1-year period, in a non-clinical sample of adults.
C1 [Fernandez-Abascal, Enrique G.] Natl Distance Educ Univ UNED, Fac Psychol, Dept Basic Psychol, Madrid, Spain.
[Cabello, Rosario] Univ Huelva, Fac Educ Sci, Dept Dev Psychol & Educ, Huelva, Spain.
[Fernandez-Berrocal, Pablo] Univ Malaga, Fac Psychol, Dept Basic Psychol, E-29071 Malaga, Spain.
[Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
[Baron-Cohen, Simon] Cambridgeshire & Peterborough NHS Fdn Trust CPFT, CLASS Clin, Cambridge, England.
RP Fernandez-Berrocal, P (reprint author), Univ Malaga, Fac Psychol, Dept Basic Psychol, Campus Teatinos S-N, E-29071 Malaga, Spain.
EM berrocal@uma.es
FU Department of Economics, Science, and Business, Junta Andalucia (Spain)
[SEJ-03036]; EU; MRC; Wellcome Trust
FX RC and PFB were supported in part by project SEJ-03036 from the
Department of Economics, Science, and Business, Junta Andalucia (Spain).
SBC was supported by the EU, the MRC, and the Wellcome Trust during the
period of this work. He was part of the NIHR CLAHRC for Cambridgeshire
and Peterborough NHS Foundation Trust.
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NR 34
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD SEP 11
PY 2013
VL 4
AR 33
DI 10.1186/2040-2392-4-33
PG 6
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254XR
UT WOS:000327203500001
PM 24020728
ER
PT J
AU Weigelt, S
Koldewyn, K
Kanwisher, N
AF Weigelt, Sarah
Koldewyn, Kami
Kanwisher, Nancy
TI Face Recognition Deficits in Autism Spectrum Disorders Are Both Domain
Specific and Process Specific
SO PLOS ONE
LA English
DT Article
ID BODY INVERSION; DEVELOPMENTAL PROSOPAGNOSIA; IDENTITY RECOGNITION;
ASPERGERS SYNDROME; BIOLOGICAL MOTION; CHILDREN; PERCEPTION; MEMORY;
PSYCHOPHYSICS; IMPAIRMENT
AB Although many studies have reported face identity recognition deficits in autism spectrum disorders (ASD), two fundamental question remains: 1) Is this deficit "process specific" for face memory in particular, or does it extend to perceptual discrimination of faces as well? And 2) Is the deficit "domain specific" for faces, or is it found more generally for other social or even nonsocial stimuli? The answers to these questions are important both for understanding the nature of autism and its developmental etiology, and for understanding the functional architecture of face processing in the typical brain. Here we show that children with ASD are impaired (compared to age and IQ-matched typical children) in face memory, but not face perception, demonstrating process specificity. Further, we find no deficit for either memory or perception of places or cars, indicating domain specificity. Importantly, we further showed deficits in both the perception and memory of bodies, suggesting that the relevant domain of deficit may be social rather than specifically facial. These results provide a more precise characterization of the cognitive phenotype of autism and further indicate a functional dissociation between face memory and face perception.
C1 [Weigelt, Sarah; Koldewyn, Kami; Kanwisher, Nancy] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Weigelt, Sarah; Koldewyn, Kami; Kanwisher, Nancy] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA.
[Weigelt, Sarah] Ruhr Univ Bochum, Dept Psychol, Bochum, Germany.
RP Weigelt, S (reprint author), MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA.
EM sarah.weigelt@rub.de
FU Ellison Medical Foundation; Simons Foundation; Daimler and Benz
Foundation
FX This research was supported by the Ellison Medical Foundation (to NK;
www.ellisonfoundation.org), the Simons Foundation (to KK, SW;
www.simonsfoundation.org) and the Daimler and Benz Foundation (SW;
www.daimler-benz-stiftung.de). The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
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NR 51
TC 3
Z9 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 11
PY 2013
VL 8
IS 9
AR e74541
DI 10.1371/journal.pone.0074541
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 248VW
UT WOS:000326734500103
PM 24040276
ER
PT J
AU Wallisch, P
Bornstein, AM
AF Wallisch, Pascal
Bornstein, Aaron M.
TI Enhanced Motion Perception as a Psychophysical Marker for Autism?
SO JOURNAL OF NEUROSCIENCE
LA English
DT Editorial Material
ID EXCITATION/INHIBITION; MODEL
C1 [Wallisch, Pascal; Bornstein, Aaron M.] NYU, New York, NY 10003 USA.
RP Wallisch, P (reprint author), NYU, 4 Washington Pl,Suite 809, New York, NY 10003 USA.
EM pascal.wallisch@nyu.edu
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NR 12
TC 0
Z9 0
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD SEP 11
PY 2013
VL 33
IS 37
BP 14631
EP U16
DI 10.1523/JNEUROSCI.2945-13.2013
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA 216WG
UT WOS:000324316200001
PM 24027263
ER
PT J
AU Eapen, V
Crncec, R
Walter, A
AF Eapen, Valsamma
Crncec, Rudi
Walter, Amelia
TI Exploring links between genotypes, phenotypes, and clinical predictors
of response to early intensive behavioral intervention in autism
spectrum disorder
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Review
DE autism spectrum disorder; genotype; phenotype; early intervention;
treatment response
ID CALLOUS-UNEMOTIONAL TRAITS; GENERAL-POPULATION; CONDUCT PROBLEMS; JOINT
ATTENTION; YOUNG-CHILDREN; FOLLOW-UP; MENTAL-RETARDATION; HOME
VIDEOTAPES; SPEECH SOUNDS; BRAIN
AB Autism spectrum disorder (ASD) is amongst the most familial of psychiatric disorders. Twin and family studies have demonstrated a monozygotic concordance rate of 70-90%, dizygotic concordance of around 10%, and more than a 20-fold increase in risk for first-degree relatives. Despite major advances in the genetics of autism, the relationship between different aspects of the behavioral and cognitive phenotype and their underlying genetic liability is still unclear. This is complicated by the heterogeneity of autism, which exists at both genetic and phenotypic levels. Given this heterogeneity, one method to find homogeneous entities and link these with specific genotypes would be to pursue endophenotypes. Evidence from neuroimaging, eye tracking, and electrophysiology studies supports the hypothesis that, building on genetic vulnerability, ASD emerges from a developmental cascade in which a deficit in attention to social stimuli leads to impaired interactions with primary caregivers. This results in abnormal development of the neurocircuitry responsible for social cognition, which in turn adversely affects later behavioral and functional domains dependent on these early processes, such as language development. Such a model begets a heterogeneous clinical phenotype, and is also supported by studies demonstrating better clinical outcomes with earlier treatment. Treatment response following intensive early behavioral intervention in ASD is also distinctly variable; however, relatively little is known about specific elements of the clinical phenotype that may predict response to current behavioral treatments. This paper overviews the literature regarding genotypes, phenotypes, and predictors of response to behavioral intervention in ASD and presents suggestions for future research to explore linkages between these that would enable better identification of, and increased treatment efficacy for, ASD.
C1 [Eapen, Valsamma; Walter, Amelia] South Western Sydney Local Hlth District, Acad Unit Psychiat South West Sydney, Liverpool, NSW, Australia.
[Eapen, Valsamma; Crncec, Rudi; Walter, Amelia] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia.
RP Eapen, V (reprint author), Mental Hlth Ctr L1, ICAMHS, Acad Unit Psychiat South West Sydney, Locked Bag 7103, Liverpool Bc, NSW 1871, Australia.
EM v.eapen@unsw.edu.au
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NR 123
TC 7
Z9 7
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 11
PY 2013
VL 7
AR 567
DI 10.3389/fnhum.2013.00567
PG 10
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 214TJ
UT WOS:000324158400001
PM 24062668
ER
PT J
AU Koshiba, M
Senoo, A
Mimura, K
Shirakawa, Y
Karino, G
Obara, S
Ozawa, S
Sekihara, H
Fukushima, Y
Ueda, T
Kishino, H
Tanaka, T
Ishibashi, H
Yamanouchi, H
Yui, K
Nakamura, S
AF Koshiba, Mamiko
Senoo, Aya
Mimura, Koki
Shirakawa, Yuka
Karino, Genta
Obara, Saya
Ozawa, Shinpei
Sekihara, Hitomi
Fukushima, Yuta
Ueda, Toyotoshi
Kishino, Hirohisa
Tanaka, Toshihisa
Ishibashi, Hidetoshi
Yamanouchi, Hideo
Yui, Kunio
Nakamura, Shun
TI A cross-species socio-emotional behaviour development revealed by a
multivariate analysis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NEWLY-HATCHED CHICKS; SOCIAL NEUROSCIENCE; BIOLOGICAL MOTION;
ATTACHMENT; AUTISM; BRAIN; OXYTOCIN; EMOTION; NEUROBIOLOGY; RECOGNITION
AB Recent progress in affective neuroscience and social neurobiology has been propelled by neuro-imaging technology and epigenetic approach in neurobiology of animal behaviour. However, quantitative measurements of socio-emotional development remains lacking, though sensory-motor development has been extensively studied in terms of digitised imaging analysis. Here, we developed a method for socio-emotional behaviour measurement that is based on the video recordings under well-defined social context using animal models with variously social sensory interaction during development. The behaviour features digitized from the video recordings were visualised in a multivariate statistic space using principal component analysis. The clustering of the behaviour parameters suggested the existence of species- and stage-specific as well as cross-species behaviour modules. These modules were used to characterise the behaviour of children with or without autism spectrum disorders (ASDs). We found that socio-emotional behaviour is highly dependent on social context and the cross-species behaviour modules may predict neurobiological basis of ASDs.
C1 [Koshiba, Mamiko; Senoo, Aya; Mimura, Koki; Shirakawa, Yuka; Karino, Genta; Obara, Saya; Ozawa, Shinpei; Sekihara, Hitomi; Fukushima, Yuta; Tanaka, Toshihisa; Nakamura, Shun] Tokyo Univ Agr & Technol, Tokyo, Japan.
[Koshiba, Mamiko; Ishibashi, Hidetoshi; Nakamura, Shun] NCNP, Natl Inst Neurosci, Tokyo, Japan.
[Ueda, Toyotoshi] Meisei Univ, Tokyo, Japan.
[Kishino, Hirohisa] Univ Tokyo, Tokyo, Japan.
[Koshiba, Mamiko; Yamanouchi, Hideo] Saitama Med Univ, Saitama, Japan.
[Yui, Kunio] Ashiya Univ, Kobe, Hyogo, Japan.
RP Koshiba, M (reprint author), Tokyo Univ Agr & Technol, Tokyo, Japan.
EM koshiba@saitama-med.ac.jp
FU MEXT [21200017, 25119509, 25282221]; MHLW [22-6]
FX This work was supported by MEXT, Grant-in-Aid for Scientific Research on
Innovative Area(21200017, 25119509, 25282221) and MHLW, Intramural
Research Grant 22-6 for Neurological and Psychiatric Disorders of the
NCNP, JST-ALCA. The authors especially thank Drs. Makiko Kaga, Masumi
Inagaki, Atsuko Gunji and Yuki Inoue for their advice regarding
developmental disorders and the anonymous reviewers for their
constructive comments on this manuscript. The authors also thank all of
TUAT, NCNP, Sawa hospital (Osaka), and Drs. Fukuoka T, Saito K, Oeda K
of Dainippon Sumitomo Pharma.
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NR 61
TC 3
Z9 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 11
PY 2013
VL 3
AR 2630
DI 10.1038/srep02630
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 214TC
UT WOS:000324157700001
PM 24022241
ER
PT J
AU Courty, A
Maria, AS
Lalanne, C
Ringuenet, D
Vindreau, C
Chevallier, C
Pouga, L
Pinabel, F
Philippe, A
Adrien, JL
Barry, C
Berthoz, S
AF Courty, Annaig
Maria, Anne Solene
Lalanne, Christophe
Ringuenet, Damien
Vindreau, Christine
Chevallier, Coralie
Pouga, Lydia
Pinabel, Franois
Philippe, Anne
Adrien, Jean-Louis
Barry, Caroline
Berthoz, Sylvie
TI Levels of autistic traits in anorexia nervosa: a comparative
psychometric study
SO BMC PSYCHIATRY
LA English
DT Article
DE Anorexia nervosa; Autism; Neuropsychology; Flexibility; Interpersonal
functioning; Empathy; Alexithymia
ID VORST ALEXITHYMIA QUESTIONNAIRE; HIGH-FUNCTIONING AUTISM; NORMAL
SEX-DIFFERENCES; EATING-DISORDERS; ASPERGER-SYNDROME; SYSTEMATIZING
QUOTIENT; COGNITIVE REMEDIATION; SPECTRUM DISORDER; EMPATHY QUOTIENT;
SHORT FORMS
AB Background: A number of characteristics associated with Autism Spectrum Disorders (ASD) are over-represented among patients with Anorexia Nervosa (AN) as well as among relatives of these patients. Yet the co-occurrence of autistic traits in AN has not been fully explored and no previous study has directly compared self-reported evaluations of cognitive and socio-affective skills in AN and ASD.
Methods: We aimed to determine the degree of overlap between AN and ASD from scores on questionnaires classically used to measure ASD impairments. Fifteen AN participants, 15 ASD participants and two groups of matched controls completed a battery of self-reports measuring: autistic traits (Autism-Spectrum Quotient), empathy (Empathy Quotient-short and Interpersonal Reactivity Index), systemizing (Systemizing Quotient-short) and alexithymia (Bermond-Vorst Alexithymia Questionnaire-B). Univariate comparisons of mean totalled scores were performed on each measure (patients vs. controls, and AN vs. ASD), and a Principal Component Analysis was used to study subject proximities in a reduced-factor space constructed from AQ, BVAQ-B and IRI subscales.
Results: These analyses revealed similarities in a few cognitive domains (Attention Switching, Perspective Taking and Fantasy, lack of emotional introspection) and in some nonspecific affective dimensions (depression and feelings of distress), but also marked dissimilarities in social skills (the ability to communicate emotions to others, empathizing).
Conclusion: The AN and ASD participants reported similar needs for sameness, and similar difficulties understanding their emotions and taking the perspective of another, but contrasting abilities to feel concerned in interpersonal situations. Our mixed findings encourage further exploration of transdiagnostic similarities and associations between these disorders.
C1 [Courty, Annaig; Berthoz, Sylvie] Inst Mutualiste Montsouris, Psychiat Serv, Dept Adolescent & Young Adult Psychiat, F-75014 Paris, France.
[Courty, Annaig; Adrien, Jean-Louis] Paris Descartes Univ, Inst Psychol, LPPS EA 4057, Paris, France.
[Ringuenet, Damien; Vindreau, Christine] Univ Paris 11, Hop Paul Brousse, AP HP, Dept Psychiat & Addictol,Eating Disorders Unit, Villejuif, France.
[Chevallier, Coralie; Pouga, Lydia] INSERM, LNC, U960, Paris, France.
[Chevallier, Coralie] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Maria, Anne Solene; Barry, Caroline; Berthoz, Sylvie] Paris Descartes Univ, Inserm Maison Solenn U669, Paris, France.
[Maria, Anne Solene; Barry, Caroline; Berthoz, Sylvie] Univ Paris 11, Paris, France.
[Pinabel, Franois] Paris Descartes Univ, Hop La Pitie Salpetriere, AP HP, Dept Child & Adolescent Psychiat, Paris, France.
[Philippe, Anne] Paris Descartes Univ, Hop Necker Enfants Malad, AP HP, Inserm U781, Paris, France.
[Philippe, Anne] Paris Descartes Univ, Hop Necker Enfants Malad, AP HP, Dept Genet, Paris, France.
[Lalanne, Christophe] St Louis Hosp, AP HP, Dept Clin Res, Paris, France.
[Lalanne, Christophe] Univ Paris 11, Inserm Unit, UMR SO 669, Paris, France.
RP Berthoz, S (reprint author), Inst Mutualiste Montsouris, Psychiat Serv, Dept Adolescent & Young Adult Psychiat, 42 Bd Jourdan, F-75014 Paris, France.
EM sylvie.berthoz@aliceadsl.fr
FU French "Fondation pour la Recherche Psychiatrique et la Sante Mentale";
Orange Fundation
FX The project was supported by the French "Fondation pour la Recherche
Psychiatrique et la Sante Mentale" and "Orange Fundation".
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NR 53
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD SEP 10
PY 2013
VL 13
AR 222
DI 10.1186/1471-244X-13-222
PG 9
WC Psychiatry
SC Psychiatry
GA 223AI
UT WOS:000324774500001
PM 24015680
ER
PT J
AU Hage, SR
Gavrilov, N
Salomon, F
Stein, AM
AF Hage, Steffen R.
Gavrilov, Natalja
Salomon, Ferdinand
Stein, Anna M.
TI Temporal vocal features suggest different call-pattern generating
mechanisms in mice and bats
SO BMC NEUROSCIENCE
LA English
DT Article
DE Acoustic communication; Bat; Mammal; Mice; Mouse model; Vocal pattern
generation
ID RUFOUS HORSESHOE BAT; ULTRASONIC VOCALIZATIONS; MOUSE MODEL;
RHINOLOPHUS-FERRUMEQUINUM; SQUIRREL-MONKEY; ECHOLOCATION; AUTISM;
COMMUNICATION; RESPIRATION; FREQUENCY
AB Background: Mice produce ultrasonic vocalizations in various inter-individual encounters and with high call rates. However, it is so far virtually unknown how these vocal patterns are generated. On the one hand, these vocal patterns could be embedded into the normal respiratory cycle, as happens in bats and other mammals that produce similar call rates and frequencies. On the other, mice could possess distinct vocal pattern generating systems that are capable of modulating the respiratory cycle, which is what happens in non-human and human primates. In the present study, we investigated the temporal call patterns of two different mammalian species, bats and mice, in order to differentiate between these two possibilities for mouse vocalizations. Our primary focus was on comparing the mechanisms for the production of rapid, successive ultrasound calls of comparable frequency ranges in the two species.
Results: We analyzed the temporal call pattern characteristics of mice, and we compared these characteristics to those of ultrasonic echolocation calls produced by horseshoe bats. We measured the distributions of call durations, call intervals, and inter-call intervals in the two species. In the bat, and consistent with previous studies, we found that call duration was independent of corresponding call intervals, and that it was negatively correlated with the corresponding inter-call interval. This indicates that echolocation call production mechanisms in the bat are highly correlated with the respiratory cycle. In contrast, call intervals in the mouse were directly correlated with call duration. Importantly, call duration was not, or was only slightly, correlated with inter-call intervals, consistent with the idea that vocal production in the mouse is largely independent of the respiratory cycle.
Conclusions: Our findings suggest that ultrasonic vocalizations in mice are produced by call-pattern generating mechanisms that seem to be similar to those that have been found in primates. This is in contrast to the production mechanisms of ultrasonic echolocation calls in horseshoe bats. These results are particularly interesting, especially since mouse vocalizations have recently attracted increased attention as potential indicators for the degree of progression of several disease patterns in mouse models for neurodegenerative and neurodevelopmental disorders of humans.
C1 [Hage, Steffen R.; Gavrilov, Natalja; Salomon, Ferdinand; Stein, Anna M.] Univ Tubingen, Inst Neurobiol, D-72076 Tubingen, Germany.
RP Hage, SR (reprint author), Univ Tubingen, Inst Neurobiol, Morgenstelle 28, D-72076 Tubingen, Germany.
EM steffen.hage@uni-tuebingen.de
FU Deutsche Forschungsgemeinschaft [Ha 5400/1-1]; Tubingen University
FX We thank Ziad Hafed and Andreas Nieder for helpful comments on the
manuscript, Walter Metzner for valuable help during data collection of
bat calls, and Ziad Hafed for proofreading the manuscript. Parts of this
study were supported by the Deutsche Forschungsgemeinschaft (Ha
5400/1-1). This study was supported by an Open Access Publishing Fund of
Deutsche Forschungsgemeinschaft and Tubingen University.
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NR 28
TC 2
Z9 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2202
J9 BMC NEUROSCI
JI BMC Neurosci.
PD SEP 10
PY 2013
VL 14
AR 99
DI 10.1186/1471-2202-14-99
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA 215WS
UT WOS:000324242200001
PM 24020588
ER
PT J
AU Truong, DT
Bonet, A
Rendall, AR
Rosen, GD
Fitch, RH
AF Truong, Dongnhu T.
Bonet, Ashley
Rendall, Amanda R.
Rosen, Glenn D.
Fitch, Roslyn H.
TI A Behavioral Evaluation of Sex Differences in a Mouse Model of Severe
Neuronal Migration Disorder
SO PLOS ONE
LA English
DT Article
ID AUDITORY-PROCESSING DEFICITS; IN-UTERO RNAI; PERIVENTRICULAR NODULAR
HETEROTOPIA; MORRIS WATER MAZE; MICE MUS-MUSCULUS; WILLIAMS-SYNDROME;
ULTRASONIC VOCALIZATIONS; READING-DISABILITY; CORPUS-CALLOSUM; MEMORY
DEFICITS
AB Disruption of neuronal migration in humans is associated with a wide range of behavioral and cognitive outcomes including severe intellectual disability, language impairment, and social dysfunction. Furthermore, malformations of cortical development have been observed in a number of neurodevelopmental disorders (e. g. autism and dyslexia), where boys are much more commonly diagnosed than girls (estimates around 4 to 1). The use of rodent models provides an excellent means to examine how sex may modulate behavioral outcomes in the presence of comparable abnormal neuroanatomical presentations. Initially characterized by Rosen et al. 2012, the BXD29-Tlr4(lps-2J)/J mouse mutant exhibits a highly penetrant neuroanatomical phenotype that consists of bilateral midline subcortical nodular heterotopia with partial callosal agenesis. In the current study, we confirm our initial findings of a severe impairment in rapid auditory processing in affected male mice. We also report that BXD29-Tlr4(lps-2J)/J (mutant) female mice show no sparing of rapid auditory processing, and in fact show deficits similar to mutant males. Interestingly, female BXD29-Tlr4(lps-2J)/J mice do display superiority in Morris water maze performance as compared to wild type females, an affect not seen in mutant males. Finally, we report new evidence that BXD29-Tlr4(lps-2J)/J mice, in general, show evidence of hyper-social behaviors. In closing, the use of the BXD29-Tlr4(lps-2J)/J strain of mice - with its strong behavioral and neuroanatomical phenotype - may be highly useful in characterizing sex independent versus dependent mechanisms that interact with neural reorganization, as well as clinically relevant abnormal behavior resulting from aberrant neuronal migration.
C1 [Truong, Dongnhu T.; Bonet, Ashley; Rendall, Amanda R.; Fitch, Roslyn H.] Univ Connecticut, Dept Psychol Behav Neurosci, Storrs, CT 06269 USA.
[Rosen, Glenn D.] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA.
RP Truong, DT (reprint author), Univ Connecticut, Dept Psychol Behav Neurosci, Storrs, CT 06269 USA.
EM dongnhu.truong@uconn.edu
FU NIH [P01HD57853]
FX This work was supported by NIH grant P01HD57853
(http://www.nichd.nih.gov). The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
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NR 67
TC 2
Z9 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 9
PY 2013
VL 8
IS 9
AR e73144
DI 10.1371/journal.pone.0073144
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 244QV
UT WOS:000326405300051
PM 24039873
ER
PT J
AU Artigas-Pallares, J
AF Artigas-Pallares, Josep
TI Autism and attention deficit hyperactivity disorder: convergences and
divergences. Genetics
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Article
DE ADHD; ASD; Attention deficit hyperactivity disorder; Autism spectrum
disorder; Autism; DSM-5; Epigenetics; Quantitative genetic traits;
Single-nucleotide polymorphisms
ID PERINATAL RISK-FACTORS; PERVASIVE DEVELOPMENTAL DISORDERS; CATECHOL
O-METHYLTRANSFERASE; GENOME-WIDE ANALYSIS; DEFICIT/HYPERACTIVITY
DISORDER; SPECTRUM DISORDERS; ANTISOCIAL-BEHAVIOR; BIPOLAR DISORDER;
TWIN SAMPLE; ADHD
AB According to the DSM-5, attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are different conditions that earlier versions of the DSM stated could not be diagnosed together in the same individual. Yet, over the last few decades the debate on the limits between the two disorders has continued, even though ADHD and ASD are undoubtedly clinically and cognitively different phenotypes, as demonstrated by the simple fact that they have been defined in clearly different ways. Thus, from a perspective anchored in a purely phenomenological view, there would be no grounds whatsoever on which to question the independence between the two disorders. Since, at the present time, the discussion on the convergence between ADHD and ASD cannot be considered to have been solved, this study aims to take the data available from genetics as the basis on which to review the nosological position of the two disorders. The main studies that have addressed this issue are reviewed. The data collected agree on a genetic overlap between ADHD and ASD, which is influenced by common molecular mechanisms that affect the two disorders at the same time. The conclusions that can be drawn from the data collected suggest a new conceptual model not only for ADHD and ASD, but also for complex mental disorders in general. This line of research will transform the way of understanding the treatment of mental disorders and will almost certainly open up new perspectives in this area.
C1 [Artigas-Pallares, Josep] Hosp Sabadell, Ctr Med Psyncron, Unidad Neuropediat, Barcelona, Spain.
RP Artigas-Pallares, J (reprint author), Rambla 172,1 4A, E-08201 Sabadell, Barcelona, Spain.
EM 7280jap@comb.cat
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NR 61
TC 1
Z9 1
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD SEP 6
PY 2013
VL 57
SU 1
BP S155
EP S161
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 225SM
UT WOS:000324982600018
PM 23897143
ER
PT J
AU Fernandez-Jaen, A
Fernandez-Mayoralas, DM
Fernandez-Perrone, AL
Calleja-Perez, B
Munoz-Jareno, N
Lopez-Arribas, S
AF Fernandez-Jaen, Alberto
Martin Fernandez-Mayoralas, Daniel
Laura Fernandez-Perrone, Ana
Calleja-Perez, Beatriz
Munoz-Jareno, Nuria
Lopez-Arribas, Sonia
TI Autism and attention deficit hyperactivity disorder: pharmacological
intervention
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Article
DE ADHD; Atomoxetine; Autism spectrum disorders; Autism; Methylphenidate
ID PERVASIVE DEVELOPMENTAL DISORDERS; DEFICIT/HYPERACTIVITY DISORDER;
SPECTRUM DISORDERS; INTELLECTUAL DISABILITY; RETROSPECTIVE ANALYSIS;
WORKING-MEMORY; OPEN-LABEL; CHILDREN; ATOMOXETINE; SYMPTOMS
AB The cardinal symptoms of attention deficit hyperactivity disorder (ADHD) -inattention, hyperactivity and impulsiveness- are not specific and may be found in the general population and in other disorders. These symptoms are present in over 50% of patients with autism spectrum disorders (ASD). It thus seems quite clear that both problems can coexist in these patients. The usual pharmacological treatments for ADHD, methylphenidate and atomoxetine, appear to be useful in reducing the above-mentioned symptoms in patients with ADHD and ASD. Effectiveness seems to be lower in patients with ASD and tolerance is slightly poorer. This may be conditioned by a number of variables, including: the complexity of ASD, association with mental retardation, polypharmacotherapy, and so on. Given the long-term tolerance profile of methylphenidate and atomoxetine, these treatments appear to be a good alternative with which to improve the problems of attention and self-control these patients have. Nevertheless, further controlled studies are needed to confirm this proposition.
C1 [Fernandez-Jaen, Alberto; Martin Fernandez-Mayoralas, Daniel; Laura Fernandez-Perrone, Ana] Hosp Univ Quiron, Secc Neurol Infantil, Serv Neuropediat, Madrid, Spain.
[Calleja-Perez, Beatriz] Ctr Salud Doctor Cirajas, Serv Pediat, Madrid, Spain.
[Munoz-Jareno, Nuria] Hosp Infanta Leonor, Serv Neuropediat, Madrid, Spain.
[Lopez-Arribas, Sonia] Hosp Gomez Ulla, Serv Psiquiat, Madrid, Spain.
RP Fernandez-Jaen, A (reprint author), Hosp Univ Quiron, Secc Neurol Infantil, Diego Velazquez 1, E-28024 Pozuelo De Alarcon, Madrid, Spain.
EM aferjaen@telefonica.net
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NR 67
TC 1
Z9 1
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD SEP 6
PY 2013
VL 57
SU 1
BP S205
EP S210
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 225SM
UT WOS:000324982600023
PM 23897149
ER
PT J
AU Martos-Perez, J
Llorente-Comi, M
AF Martos-Perez, Juan
Llorente-Comi, Maria
TI Treatment of autism spectrum disorders: union between understanding and
evidence-based practice
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Article
DE Autism spectrum disorders; Early intervention; Evidence-based practice;
Treatment; Treatment in children and adolescents
AB Introduction. Synthetically realizes heterogeneous operating characteristics of people with autism spectrum disorders (ASD) and how these features can also be based on the variability in response to treatment. It emphasizes the need to combine, in treatment, evidence-based practice with a deep understanding of ASD.
Development. It explains some of the key principles that should guide the treatment from the standpoint of quality indicators should include intervention programs, to then influence the features and content that are part of the programs carried out in the field early intervention, briefly explaining some of these programs and then characterize the intervention, with the use of techniques and strategies, which is usually carried out with children and adolescents in high-functioning.
Conclusion. Research and accumulated knowledge and the increasing experimental evidence configure the features to be taken by intervention and treatment programs that are used with people with ASD. Such treatment should begin early, as soon as possible and spread over the life cycle.
C1 [Martos-Perez, Juan; Llorente-Comi, Maria] Deletrea Diagnost Evaluac Lenguaje & Tratamiento, Madrid, Spain.
RP Martos-Perez, J (reprint author), Deletrea, Doctor Esquerdo 82, E-28027 Madrid, Spain.
EM deletrea@telefonica.net
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NR 18
TC 0
Z9 0
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD SEP 6
PY 2013
VL 57
SU 1
BP S185
EP S191
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 225SM
UT WOS:000324982600021
PM 23897147
ER
PT J
AU Miranda-Casas, A
Baixauli-Fortea, I
Colomer-Diago, C
Rosello-Miranda, B
AF Miranda-Casas, Ana
Baixauli-Fortea, Immaculada
Colomer-Diago, Carla
Rosello-Miranda, Belen
TI Autism and attention deficit hyperactivity disorder: similarities and
differences in executive functioning and theory of mind
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Article
DE ADHD; Autism; Executive functioning; Flexibility; Inhibition; Theory of
mind
ID CHILDRENS-COMMUNICATION-CHECKLIST; SPECTRUM DISORDERS;
DEFICIT/HYPERACTIVITY DISORDER; SUSTAINED ATTENTION; ADHD; RECOGNITION;
PROFILES; SYMPTOMS; DYSFUNCTION; IMPAIRMENT
AB Introduction. Although the DSM-IV-TR diagnostic criteria do not overlap, the presence of attention deficit hyperactivity disorder (ADHD) symptoms in individuals with a clinical diagnosis of autism is quite high. At the same time, children with ADHD can have autistic traits, the most prevalent being social and communication difficulties. The analysis of the combination of executive functions and theory of mind (ToM) deficits could help to explain the overlap and differentiation between the two disorders.
Aim. To review the findings of empirical studies in which children with ADHD and autism have been compared on indicators of executive functions and ToM.
Development. The literature review suggests the existence of distinct patterns in autism spectrum disorders (ASD) and ADHD when the executive functioning is segmented by components. Children with ADHD experience deficits in inhibitory control, while children with ASD have problems with cognitive flexibility and planning. Regarding the domain of the mentalist skills, there are developmental differences, as well as differences in their severity. Younger children with ASD have greater deficiencies in the ToM compared to children with ADHD, and a primary deficit in social orientation.
Conclusion. Although important progress has been made, some issues remain to be clarified, among which we can highlight the analysis of how ToM development affects poor executive functions development, using longitudinal studies that analyze the developmental paths of children with ASD and children with ADHD.
C1 [Miranda-Casas, Ana; Colomer-Diago, Carla] Univ Valencia, Dept Psicol Evolut & Educ, E-46010 Valencia, Spain.
[Baixauli-Fortea, Immaculada] Univ Catolica Valencia, Dept Ciencias Ocupac Psicol Evolut & Educ, Valencia, Spain.
[Rosello-Miranda, Belen] Hosp Univ La Fe, Serv Neuropediat, Valencia, Spain.
RP Miranda-Casas, A (reprint author), Univ Valencia, Dept Psicol Evolut & Educ, Avda Blasco Ibanez 21, E-46010 Valencia, Spain.
EM ana.miranda@uv.es
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NR 48
TC 2
Z9 2
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD SEP 6
PY 2013
VL 57
SU 1
BP S177
EP S184
PG 8
WC Clinical Neurology
SC Neurosciences & Neurology
GA 225SM
UT WOS:000324982600020
PM 23897146
ER
PT J
AU Proal, E
Gonzalez-Olvera, J
Blancas, AS
Chalita, PJ
Castellanos, FX
AF Proal, Erika
Gonzalez-Olvera, Jorge
Blancas, Aurea S.
Chalita, Pablo J.
Castellanos, F. Xavier
TI Neurobiology of autism and attention deficit hyperactivity disorder by
means of neuroimaging techniques: convergences and divergences
SO REVISTA DE NEUROLOGIA
LA Spanish
DT Article
DE ADHD; Autism spectrum disorders; Magnetic resonance imaging;
Meta-analysis; Volumetric measurement
ID LIKELIHOOD ESTIMATION METAANALYSIS; INTRINSIC FUNCTIONAL CONNECTIVITY;
SPECTRUM DISORDERS; DEFICIT/HYPERACTIVITY DISORDER; ALE METAANALYSIS;
BRAIN; CHILDREN; ADHD; FMRI; ABNORMALITIES
AB In the clinical area, some symptoms of attention deficit hyperactivity disorder (ADHD) also present in patients with autism spectrum disorders (ASD). Research has shown that there are alterations in brain circuits that have an impact upon specific cognitive and behavioural failures in each of these disorders. Yet, little research has been conducted on the brain correlates underlying both the similarities and the differences in the symptoms. In this review, the structural and functional meta-analytical studies that have been carried out to date on ADHD and ASD have been analysed. On the one hand, there are convergences in the attentional dorsal, executive functions, visual, somatomotor circuits and the default activation circuit. These similarities can account for the comorbid manifestations between the disorders, such as failure in the integration of information, fine motor control and specific attention processes. On the other hand, specifically in ADHD, there is a deficit in the reward circuit and in the attentional ventral, which are systems involved in the measurement of the effects of reinforcement and monitoring of attention. In ASD, the circuits that are most strongly affected are those involved in social cognition and language processes. In conclusion, there are neuronal correlates in both disorders that explain both the convergent and divergent clinical and behavioural manifestations.
C1 [Proal, Erika; Blancas, Aurea S.] Inst Invest NeuroMOBIUS, Mexico City, DF, Mexico.
[Proal, Erika; Blancas, Aurea S.; Chalita, Pablo J.] NEUROingenia Clin Ctr, Mexico City 11560, DF, Mexico.
[Proal, Erika; Castellanos, F. Xavier] NYU, Child Study Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY USA.
[Gonzalez-Olvera, Jorge] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Mexico City, DF, Mexico.
[Castellanos, F. Xavier] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
RP Proal, E (reprint author), NEUROingenia Clin Ctr, Eugenio Sue 355,Interior 104, Mexico City 11560, DF, Mexico.
EM erikaproal@neuroingenia.com
RI Gonzalez-Olvera, Jorge Julio/C-1630-2014
OI Gonzalez-Olvera, Jorge Julio/0000-0001-6325-7434
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NR 69
TC 0
Z9 0
PU REVISTA DE NEUROLOGIA
PI BARCELONA
PA C/O CESAR VIGUERA, EDITOR, APDO 94121, 08080 BARCELONA, SPAIN
SN 0210-0010
J9 REV NEUROLOGIA
JI Rev. Neurologia
PD SEP 6
PY 2013
VL 57
SU 1
BP S163
EP S175
PG 13
WC Clinical Neurology
SC Neurosciences & Neurology
GA 225SM
UT WOS:000324982600019
PM 23897144
ER
PT J
AU Clements-Stephens, AM
Vasiljevic, K
Murray, AJ
Shelton, AL
AF Clements-Stephens, Amy M.
Vasiljevic, Katarina
Murray, Alexandra J.
Shelton, Amy L.
TI The role of potential agents in making spatial perspective taking social
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Article
DE perspective taking; social skills; agency; individual differences;
spatial cognition
ID FUNCTIONING AUTISM; CHILDREN; TRAITS; SKILLS; SELF
AB A striking relationship between visual spatial perspective taking (VSPT) and social skills has been demonstrated for perspective taking tasks in which the target of the imagined or inferred perspective is a potential agent, suggesting that the presence of a potential agent may create a social context for the seemingly spatial task of imagining a novel visual perspective. In a series of studies, we set out to investigate how and when a target might be viewed as sufficiently agent-like to incura social influence on VSPT performance. By varying the perceptual and conceptual features that defined the targets as potential agents, we find that even something as simple as suggesting animacy for a simple wooden block may be sufficient. More critically, we found that experience with one potential agent influenced the performance with subsequent targets, either by inducing or eliminating the influence of social skills on VSPT performance. These carry over effects suggest that the relationship between social skills and VSPT performance is mediated by a complex relationship that includes the task, the target, and the context in which that target is perceived. These findings highlight potential problems that arise when identifying a task as belonging exclusively to a single cognitive domain and stress instead the highly interactive nature of cognitive domains and their susceptibility to cross-domain individual differences.
C1 [Clements-Stephens, Amy M.; Shelton, Amy L.] Johns Hopkins Univ, Sch Educ, Baltimore, MD 21218 USA.
[Clements-Stephens, Amy M.; Shelton, Amy L.] Johns Hopkins Univ, Ctr Talented Youth, Baltimore, MD 21218 USA.
[Clements-Stephens, Amy M.; Vasiljevic, Katarina; Murray, Alexandra J.; Shelton, Amy L.] Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA.
RP Shelton, AL (reprint author), Johns Hopkins Univ, Sch Educ, 3400 North Charles St, Baltimore, MD 21218 USA.
EM ashelton@jhu.edu
FU Woodrow Wilson under-graduate research fellowship
FX We would like to thank Ben Nelligan for helpful comments on previous
versions of this manuscript. Portions of this work were supported in
part by a Woodrow Wilson under-graduate research fellowship that was
awarded to Alexandra J. Murray.
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NR 24
TC 2
Z9 2
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 5
PY 2013
VL 7
AR 497
DI 10.3389/fnhum.2013.00497
PG 11
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 211PN
UT WOS:000323921500001
PM 24046735
ER
PT J
AU Plasschaert, RN
Bartolomei, MS
AF Plasschaert, Robert N.
Bartolomei, Marisa S.
TI AUTISM A long genetic explanation
SO NATURE
LA English
DT Editorial Material
ID MUTATIONS; SPECTRUM
C1 [Plasschaert, Robert N.; Bartolomei, Marisa S.] Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.
RP Plasschaert, RN (reprint author), Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.
EM bartolom@mail.med.upenn.edu
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NR 8
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD SEP 5
PY 2013
VL 501
IS 7465
BP 36
EP 37
PG 2
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 211ER
UT WOS:000323888300022
PM 23995684
ER
PT J
AU King, IF
Yandava, CN
Mabb, AM
Hsiao, JS
Huang, HS
Pearson, BL
Calabrese, JM
Starmer, J
Parker, JS
Magnuson, T
Chamberlain, SJ
Philpot, BD
Zylka, MJ
AF King, Ian F.
Yandava, Chandri N.
Mabb, Angela M.
Hsiao, Jack S.
Huang, Hsien-Sung
Pearson, Brandon L.
Calabrese, J. Mauro
Starmer, Joshua
Parker, Joel S.
Magnuson, Terry
Chamberlain, Stormy J.
Philpot, Benjamin D.
Zylka, Mark J.
TI Topoisomerases facilitate transcription of long genes linked to autism
SO NATURE
LA English
DT Article
ID RNA-POLYMERASE-II; DE-NOVO MUTATIONS; SPECTRUM DISORDERS; EXPRESSION
SIGNATURES; BETA; CHROMATIN; UBE3A; CAMPTOTHECIN; TEMPLATE; ANGELMAN
AB Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expression of extremely long genes in mouse and human neurons, including nearly all genes that are longer than 200 kilobases. Expression of long genes is also reduced after knockdown of Top1 or Top2b in neurons, highlighting that both enzymes are required for full expression of long genes. By mapping RNA polymerase II density genome-wide in neurons, we found that this length-dependent effect on gene expression was due to impaired transcription elongation. Interestingly, many high-confidence ASD candidate genes are exceptionally long and were reduced in expression after TOP1 inhibition. Our findings suggest that chemicals and genetic mutations that impair topoisomerases could commonly contribute to ASD and other neurodevelopmental disorders.
C1 [King, Ian F.; Mabb, Angela M.; Huang, Hsien-Sung; Pearson, Brandon L.; Philpot, Benjamin D.; Zylka, Mark J.] Univ N Carolina, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA.
[Yandava, Chandri N.; Philpot, Benjamin D.; Zylka, Mark J.] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
[Hsiao, Jack S.; Chamberlain, Stormy J.] Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06032 USA.
[Calabrese, J. Mauro; Starmer, Joshua; Parker, Joel S.; Magnuson, Terry] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
[Parker, Joel S.; Magnuson, Terry] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
[Philpot, Benjamin D.; Zylka, Mark J.] Univ N Carolina, UNC Neurosci Ctr, Chapel Hill, NC 27599 USA.
RP Philpot, BD (reprint author), Univ N Carolina, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA.
EM bphilpot@med.unc.edu; zylka@med.unc.edu
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NR 48
TC 33
Z9 34
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD SEP 5
PY 2013
VL 501
IS 7465
BP 58
EP +
DI 10.1038/nature12504
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 211ER
UT WOS:000323888300031
PM 23995680
ER
PT J
AU Chamberlain, PD
Rodgers, J
Crowley, MJ
White, SE
Freeston, MH
South, M
AF Chamberlain, Paul D.
Rodgers, Jacqui
Crowley, Michael J.
White, Sarah E.
Freeston, Mark H.
South, Mikle
TI A potentiated startle study of uncertainty and contextual anxiety in
adolescents diagnosed with autism spectrum disorder
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum disorder; Anxiety; Fear; Potentiated startle; Eye blink;
EMG; Intolerance of uncertainty; Psychophysiology; Repetitive behavior
ID UNPREDICTABLE AVERSIVE EVENTS; PANIC DISORDER; FEAR; RESPONSES;
CHILDREN; REVERSAL; AROUSAL; STRESS; BRAIN
AB Background: Beyond the core symptoms of autism spectrum disorder (ASD), associated symptoms of anxiety can cause substantial impairment for individuals affected by ASD and those who care for them.
Methods: We utilized a potentiated startle paradigm with a puff of air to the neck as the unconditioned stimulus in order to investigate differences between response to cued fear and contextual anxiety among cognitively able adolescents diagnosed with ASD and an age-and IQ-matched typically developing group.
Results: In a threat-modulated startle paradigm, response patterns to neutral, predictable, and unpredictable conditions were comparable across typically developing and ASD youth in terms of startle response magnitude and latency. However, the ASD group showed significantly greater absolute startle responsivity at baseline and throughout the experiment, suggesting possibly enhanced general sensitivity to threatening contexts. The ASD group, but not the control group, demonstrated moderate to strong negative correlations between psychophysiological response to unpredictable threats (uncertainty) and questionnaire measures of generalized anxiety, intolerance of uncertainty, and repetitive behavior.
Conclusions: Our data suggest enhanced general reactivity among the ASD group, possibly reflecting greater sensitivity to the threatening context of the startle paradigm. Associations with the response to uncertainty may help explain shared neurobehavioral mechanisms in ASD and anxiety. This task can provide useful targets for future neuroimaging and genetics studies as well as specific avenues for intervention. We emphasize the importance of further basic and clinical research into links among these important constructs.
C1 [Chamberlain, Paul D.; South, Mikle] Brigham Young Univ, Ctr Neurosci, Provo, UT 84602 USA.
[Rodgers, Jacqui; Freeston, Mark H.] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Crowley, Michael J.] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT 06520 USA.
[White, Sarah E.] Univ Calif Davis, Ctr Neurosci, Davis, CA 95618 USA.
[South, Mikle] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA.
RP South, M (reprint author), Brigham Young Univ, Ctr Neurosci, S192 ESC, Provo, UT 84602 USA.
EM south@byu.edu
FU Newcastle University; Brigham Young University; NIHR; Northumberland;
Tyne; Wear NHS Trust; Bial Foundation; NARSAD Young Investigator Award
FX We especially thank Anja Schmitz for sharing critical details of the
implementation of the NPU-threat task [12]. This project was generously
supported by a Visiting Fellowship provided to MS from Newcastle
University. PDC received an Office of Research and Creative Activities
Undergraduate Research Award from Brigham Young University. JR and MHF
were supported by an NIHR, Flexibility and Sustainability Award from
Northumberland, Tyne and Wear NHS Trust. MJC was supported by a grant
from the Bial Foundation and a NARSAD Young Investigator Award. The
authors wish to thank Nick Top and Ammoren Dohm for their assistance in
data collection and extraction.
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NR 38
TC 5
Z9 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD SEP 4
PY 2013
VL 4
AR 31
DI 10.1186/2040-2392-4-31
PG 11
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254XN
UT WOS:000327203000002
PM 24007557
ER
PT J
AU Stamova, BS
Tian, YF
Nordahl, CW
Shen, MD
Rogers, S
Amaral, DG
Sharp, FR
AF Stamova, Boryana S.
Tian, Yingfang
Nordahl, Christine W.
Shen, Mark D.
Rogers, Sally
Amaral, David G.
Sharp, Frank R.
TI Evidence for differential alternative splicing in blood of young boys
with autism spectrum disorders
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism; ASD; RNA; Splicing; Head size; Gene expression
ID CENTRAL-NERVOUS-SYSTEM; RNA-POLYMERASE-II; DE-NOVO MUTATIONS;
MITOCHONDRIAL DYSFUNCTION; COMMUNICATION DEFICITS; NEURONAL DEVELOPMENT;
CORTICAL DEVELOPMENT; ANTIOXIDANT ENZYMES; IMMUNE DYSFUNCTION; HEAD
CIRCUMFERENCE
AB Background: Since RNA expression differences have been reported in autism spectrum disorder (ASD) for blood and brain, and differential alternative splicing (DAS) has been reported in ASD brains, we determined if there was DAS in blood mRNA of ASD subjects compared to typically developing (TD) controls, as well as in ASD subgroups related to cerebral volume.
Methods: RNA from blood was processed on whole genome exon arrays for 2-4-year-old ASD and TD boys. An ANCOVA with age and batch as covariates was used to predict DAS for ALL ASD (n=30), ASD with normal total cerebral volumes (NTCV), and ASD with large total cerebral volumes (LTCV) compared to TD controls (n=20).
Results: A total of 53 genes were predicted to have DAS for ALL ASD versus TD, 169 genes for ASD_NTCV versus TD, 1 gene for ASD_LTCV versus TD, and 27 genes for ASD_LTCV versus ASD_NTCV. These differences were significant at P <0.05 after false discovery rate corrections for multiple comparisons (FDR <5% false positives). A number of the genes predicted to have DAS in ASD are known to regulate DAS (SFPQ, SRPK1, SRSF11, SRSF2IP, FUS, LSM14A). In addition, a number of genes with predicted DAS are involved in pathways implicated in previous ASD studies, such as ROS monocyte/macrophage, Natural Killer Cell, mTOR, and NGF signaling. The only pathways significant after multiple comparison corrections (FDR <0.05) were the Nrf2-mediated reactive oxygen species (ROS) oxidative response (superoxide dismutase 2, catalase, peroxiredoxin 1, PIK3C3, DNAJC17, microsomal glutathione S-transferase 3) and superoxide radical degradation (SOD2, CAT).
Conclusions: These data support differences in alternative splicing of mRNA in blood of ASD subjects compared to TD controls that differ related to head size. The findings are preliminary, need to be replicated in independent cohorts, and predicted alternative splicing differences need to be confirmed using direct analytical methods.
C1 [Stamova, Boryana S.; Tian, Yingfang; Nordahl, Christine W.; Shen, Mark D.; Rogers, Sally; Amaral, David G.; Sharp, Frank R.] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
[Stamova, Boryana S.; Tian, Yingfang; Sharp, Frank R.] Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA.
[Nordahl, Christine W.; Shen, Mark D.; Rogers, Sally; Amaral, David G.] Univ Calif Davis, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
[Tian, Yingfang] Shaanxi Normal Univ, Coll Life Sci, Xian 710062, Peoples R China.
[Stamova, Boryana S.] Univ Calif Davis, MIND Inst Res Wet Labs, Sacramento, CA 95817 USA.
RP Stamova, BS (reprint author), Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
EM boryana.stamova@ucdmc.ucdavis.edu
FU MIND Institute; UC Davis Children's Miracle Network; ARRA
[1R01MH089626]; Science Technology Foundation of Shaanxi Province, PR
China [2012K16-03-05]
FX The study was supported by the MIND Institute (FRS), the UC Davis
Children's Miracle Network (FRS and BS), and by ARRA funding
1R01MH089626 to DGA. Dr. Yingfang Tian was supported by Science
Technology Foundation of Shaanxi Province, PR China (2012K16-03-05).
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NR 115
TC 3
Z9 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD SEP 4
PY 2013
VL 4
AR 30
DI 10.1186/2040-2392-4-30
PG 16
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254XN
UT WOS:000327203000001
PM 24007566
ER
PT J
AU Velmeshev, D
Magistri, M
Faghihi, MA
AF Velmeshev, Dmitry
Magistri, Marco
Faghihi, Mohammad Ali
TI Expression of non-protein-coding antisense RNAs in genomic regions
related to autism spectrum disorders
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism; ASDs; Epigenetics; IncRNAs; NATs; ncRNAs
ID LONG NONCODING RNAS; MOLECULAR-MECHANISMS; GENE-EXPRESSION;
NERVOUS-SYSTEM; IN-VIVO; TRANSCRIPTS; DIFFERENTIATION; CHROMATIN;
EVOLUTION; BRAIN
AB Background: Autism spectrum disorders (ASD) manifest with neurodevelopmental phenotypes including communicative, social and behavioral impairments that affect as many as 1 in 88 children. The majority of autism cases have no known genetic cause, suggesting complex genetics of the disorder, but a few genes of large effect have been identified.
Methods: In order to identify novel ASD genetic correlates, we investigated non-protein coding RNAs (ncRNAs) which are abundantly transcribed from the human genome, enriched in the brain, and have been implicated in neurodevelopmental disorders. Using an algorithm that we developed, we examined a publicly available transcriptomics database, AceView, to identify the natural antisense transcripts (NATs) that overlap with known autism-related genes. We validated the presence and differential expression of NATs in different brain regions of ASD and control brains using qRT-PCR. Additionally, we investigated the subcellular localization of these transcripts in a neuronal cell line using RNA-sequencing (RNA-seq).
Results: We found noncoding antisense RNA transcripts at approximately 40% of loci previously implicated in ASD. We confirmed the expression of 10 antisense RNAs in different postmortem human brain tissues. The expression of five antisense transcripts was found to be region-specific, suggesting a role for these ncRNAs in the development and function of specific brain regions. Some antisense RNAs overlapping suspected ASD genes exhibited concordant expression relative to their sense protein-coding genes, while other sense-antisense pairs demonstrate a discordant relationship. Interestingly, the antisense RNA corresponding to the SYNGAP1 locus (SYNGAP1-AS) was found to be differentially expressed in brain regions of patients with ASD compared to control individuals. RNA-seq analysis of subcellular compartments from SH-SY5Y human neuroblastoma cells demonstrated that antisense RNAs to ASD candidate genes are predominantly expressed in the nucleoplasmic or chromatin compartments, implying their involvement in nuclear-associated processes.
Conclusions: Our data suggests that NATs are abundantly expressed from ASD-related loci and provide evidence for their roles in target gene regulation, neurodevelopment and autism pathogenesis. This class of RNA should therefore be considered in functional studies aimed at understanding genetic risk factors for ASD.
C1 [Faghihi, Mohammad Ali] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA.
Univ Miami, Miller Sch Med, Ctr Therapeut Innovat, Miami, FL 33136 USA.
RP Faghihi, MA (reprint author), Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, 1501 NW 10th Ave,BRB-407, Miami, FL 33136 USA.
EM mfaghihi@med.miami.edu
FU Margaret Q. Landenberger Foundation; Swiss National Science Foundation
FX The Margaret Q. Landenberger Foundation generously supported this work.
Funding from the Swiss National Science Foundation supported Dr. Marco
Magistri. We are thankful to Dr. Zane Zeier as well as to Roya
Pedram-Fatemi and Veronica Peschansky for careful reading of the
manuscript. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
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NR 66
TC 5
Z9 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD SEP 4
PY 2013
VL 4
AR 32
DI 10.1186/2040-2392-4-32
PG 12
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA 254XN
UT WOS:000327203000003
PM 24007600
ER
PT J
AU Furumi, F
Koyasu, M
AF Furumi, Fumikazu
Koyasu, Masuo
TI Role-Play Experience Facilitates Reading the Mind of Individuals with
Different Perception
SO PLOS ONE
LA English
DT Article
ID PERSPECTIVE; KNOWLEDGE; REPRESENTATION; COMPREHENSION; CHILDREN;
BELIEFS; AUTISM
AB The present study examined effects of role-play experience on reading the mind of people with different perception. It is normally difficult but very important in daily life to understand people with different characteristics, including those with restricted color vision. We explored the mechanisms of reading the mind of people with different perception. Forty university students were introduced to a communication task in which the use of mindreading was essential. During each trial, participants viewed a shelf, presented on a laptop computer, which contained several familiar objects, and they were instructed to touch an object on the shelf following an instruction issued by a partner who stood at the opposite side of the shelf. There were two partners: one was a monkey with normal color vision and the other was a dog with restricted color vision. The monkey could see all the objects in the same colors as the participants, whereas the dog saw some objects in different colors (e. g., he saw as yellow objects that the participants saw as red). Participants were required to respond according to the partner's instruction. In the restricted color vision condition, the dog saw the colors of objects differently; thus, participants had to work out his intentions (i.e., mind read), according to his different perspective. In the normal color vision condition, all objects were in the same colors as those seen by the monkey. Before the test phase, the role-play group had a role-play experience in which participants assumed the role of people with restricted color vision. No-role-play participants made significantly more errors in the restricted color vision condition than in the normal color vision condition, whereas among role-play participants, there was no difference between conditions. These results suggest that role-play experience facilitates reading the mind of people with perceptual experiences different from our own.
C1 [Furumi, Fumikazu; Koyasu, Masuo] Kyoto Univ, Grad Sch Educ, Kyoto, Japan.
[Furumi, Fumikazu] Japan Soc Promot Sci, Tokyo, Japan.
RP Furumi, F (reprint author), Kyoto Univ, Grad Sch Educ, Kyoto, Japan.
EM fumikazu.furumi@gmail.com
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TC 1
Z9 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 4
PY 2013
VL 8
IS 9
AR e74899
DI 10.1371/journal.pone.0074899
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 219OE
UT WOS:000324515600160
PM 24023966
ER
PT J
AU Basson, MA
Wingate, RJ
AF Basson, M. Albert
Wingate, Richard J.
TI Congenital hypoplasia of the cerebellum: developmental causes and
behavioral consequences
SO FRONTIERS IN NEUROANATOMY
LA English
DT Review
DE cerebellum; development; defects; hypoplasia; genetics; function;
behavior; autism spectrum disorders
ID DANDY-WALKER MALFORMATION; AUTISM SPECTRUM DISORDER; GRANULE NEURON
PRECURSORS; ENGRAILED HOMEOBOX GENES; SONIC HEDGEHOG; JOUBERT-SYNDROME;
ISTHMIC ORGANIZER; RHOMBIC-LIP; PONTOCEREBELLAR HYPOPLASIA; MOUSE
CEREBELLUM
AB Over the last 60 years, the spotlight of research has periodically returned to the cerebellum as new techniques and insights have emerged. Because of its simple homogeneous structure, limited diversity of cell types and characteristic behavioral pathologies, the cerebellum is a natural home for studies of cell specification, patterning, and neuronal migration. However, recent evidence has extended the traditional range of perceived cerebellar function to include modulation of cognitive processes and implicated cerebellar hypoplasia and Purkinje neuron hypo-cellularity with autistic spectrum disorder. In the light of this emerging frontier, we review the key stages and genetic mechanisms behind cerebellum development. In particular, we discuss the role of the midbrain hindbrain isthmic organizer in the development of the cerebellar vermis and the specification and differentiation of Purkinje cells and granule neurons. These developmental processes are then considered in relation to recent insights into selected human developmental cerebellar defects: Joubert syndrome, Dandy-Walker malformation, and pontocerebellar hypoplasia. Finally, we review current research that opens up the possibility of using the mouse as a genetic model to study the role of the cerebellum in cognitive function.
C1 [Basson, M. Albert] Kings Coll London, Dept Craniofacial Dev & Stem Cell Biol, London SE1 9RT, England.
[Basson, M. Albert; Wingate, Richard J.] Kings Coll London, MRC, Ctr Dev Neurobiol, London SE1 9RT, England.
RP Basson, MA (reprint author), Kings Coll London, Dept Craniofacial Dev & Stem Cell Biol, Floor 27,Guys Hosp Tower Wing, London SE1 9RT, England.
EM albert.basson@kcl.ac.uk
RI Wingate, Richard/C-5341-2009
FU Medical Research Council [MR/K022377]; Wellcome Trust [091475]
FX This work is supported by grants from the Medical Research Council
(MR/K022377) and Wellcome Trust (091475).
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Yu TA, 2011, DEVELOPMENT, V138, P2957, DOI 10.1242/dev.063784
NR 154
TC 10
Z9 10
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5129
J9 FRONT NEUROANAT
JI Front. Neuroanat.
PD SEP 3
PY 2013
VL 7
AR 29
DI 10.3389/fnana.2013.00029
PG 16
WC Anatomy & Morphology; Neurosciences
SC Anatomy & Morphology; Neurosciences & Neurology
GA 223JQ
UT WOS:000324801100001
PM 24027500
ER
PT J
AU Gotts, SJ
Jo, HJ
Wallace, GL
Saad, ZS
Cox, RW
Martin, A
AF Gotts, Stephen J.
Jo, Hang Joon
Wallace, Gregory L.
Saad, Ziad S.
Cox, Robert W.
Martin, Alex
TI Two distinct forms of functional lateralization in the human brain
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE specialization; asymmetry; intelligence; segregation; circuit
ID AUTISM SPECTRUM DISORDERS; HEMISPHERIC-SPECIALIZATION; CEREBRAL
HEMISPHERES; NEURAL BASIS; LANGUAGE; ORGANIZATION; ATTENTION; NETWORKS;
CORTEX; CONNECTIVITY
AB The hemispheric lateralization of certain faculties in the human brain has long been held to be beneficial for functioning. However, quantitative relationships between the degree of lateralization in particular brain regions and the level of functioning have yet to be established. Here we demonstrate that two distinct forms of functional lateralization are present in the left vs. the right cerebral hemisphere, with the left hemisphere showing a preference to interact more exclusively with itself, particularly for cortical regions involved in language and fine motor coordination. In contrast, right-hemisphere cortical regions involved in visuospatial and attentional processing interact in a more integrative fashion with both hemispheres. The degree of lateralization present in these distinct systems selectively predicted behavioral measures of verbal and visuospatial ability, providing direct evidence that lateralization is associated with enhanced cognitive ability.
C1 [Gotts, Stephen J.; Wallace, Gregory L.; Martin, Alex] NIMH, Sect Cognit Neuropsychol, Lab Brain & Cognit, Bethesda, MD 20892 USA.
[Jo, Hang Joon; Saad, Ziad S.; Cox, Robert W.] NIMH, Sci & Stat Comp Core, NIH, Bethesda, MD 20892 USA.
RP Jo, HJ (reprint author), NIMH, Sci & Stat Comp Core, NIH, Bethesda, MD 20892 USA.
EM hangjoon.jo@nih.gov
RI JO, HANG JOON/D-1775-2011
OI JO, HANG JOON/0000-0002-9180-3831
FU National Institute of Mental Health, National Institutes of Health,
Division of Intramural Research
FX We thank Allen Braun, Kyle Simmons, Kelly Barnes, and Dale Stevens for
helpful discussions; Gang Chen for advice on statistics; and Eunice
Dixon, Ian Eisenberg, Lydia Milbury, Shawn Milleville, Briana
Robustelli, and Henry Tessler for aid in data collection. This study was
supported by the National Institute of Mental Health, National
Institutes of Health, Division of Intramural Research, and it was
conducted under National Institutes of Health Clinical Study Protocol
10-M-0027 (ClinicalTrials.gov ID NCT01031407).
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NR 67
TC 18
Z9 18
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD SEP 3
PY 2013
VL 110
IS 36
BP E3435
EP E3444
DI 10.1073/pnas.1302581110
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 211DY
UT WOS:000323886200012
PM 23959883
ER
PT J
AU Verga, L
Kotz, SA
AF Verga, Laura
Kotz, Sonja A.
TI How relevant is social interaction in second language learning?
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Review
DE language; learning; social interaction; communication; joint attention
ID EARLY LANGUAGE-ACQUISITION; JOINT ATTENTION; GESTURAL COMMUNICATION;
MEANING ACQUISITION; FRONTAL-CORTEX; WORD MEANINGS; BRAIN BASIS;
COGNITION; MIRROR; COORDINATION
AB Verbal language is the most widespread mode of human communication, and an intrinsically social activity. This claim is strengthened by evidence emerging from different fields, which clearly indicates that social interaction influences human communication, and more specifically, language learning. Indeed, research conducted with infants and children shows that interaction with a caregiver is necessary to acquire language. Further evidence on the influence of sociality on language comes from social and linguistic pathologies, in which deficits in social and linguistic abilities are tightly intertwined, as is the case for Autism, for example. However, studies on adult second language (L2) learning have been mostly focused on individualistic approaches, partly because of methodological constraints, especially of imaging methods. The question as to whether social interaction should be considered as a critical factor impacting upon adult language learning still remains underspecified. Here, we review evidence in support of the view that sociality plays a significant role in communication and language learning, in an attempt to emphasize factors that could facilitate this process in adult language learning. We suggest that sociality should be considered as a potentially influential factor in adult language learning and that future studies in this domain should explicitly target this factor.
C1 [Verga, Laura; Kotz, Sonja A.] Max Planck Inst Human Cognit & Brain Sci, Res Grp Subcort Contribut Comprehens, Dept Neuropsychol, D-04103 Leipzig, Germany.
[Kotz, Sonja A.] Univ Manchester, Sch Psychol Sci, Manchester, Lancs, England.
RP Verga, L (reprint author), Max Planck Inst Human Cognit & Brain Sci, Res Grp Subcort Contribut Comprehens, Dept Neuropsychol, Stephanstr 1A, D-04103 Leipzig, Germany.
EM verga@cbs.mpg.de
FU European Community [238157]
FX Laura Verga has received funding from the European Community's Seventh
Framework Programme under the EBRAMUS project-grant agreement no 238157.
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NR 96
TC 1
Z9 1
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD SEP 3
PY 2013
VL 7
AR 550
DI 10.3389/fnhum.2013.00550
PG 7
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 210IG
UT WOS:000323824000001
PM 24027521
ER
PT J
AU Kim, CH
Lee, SC
Shin, JW
Chung, KJ
Lee, SH
Shin, MS
Baek, SB
Sung, YH
Kim, CJ
Kim, KH
AF Kim, Chang-Hee
Lee, Sang-Chul
Shin, Je Wook
Chung, Kyung-Jin
Lee, Shin-Ho
Shin, Mal-Soon
Baek, Sang-Bin
Sung, Yun-Hee
Kim, Chang-Ju
Kim, Khae-Hawn
TI Exposure to Music and Noise During Pregnancy Influences Neurogenesis and
Thickness in Motor and Somatosensory Cortex of Rat Pups
SO INTERNATIONAL NEUROUROLOGY JOURNAL
LA English
DT Article
DE Music; Noise; Neurogenesis; Motor cortex; Somatosensory cortex
ID PRENATAL MATERNAL STRESS; PROJECT ICE STORM; CHILDREN; HEARING; AUTISM;
MEMORY
AB Purpose: Prenatal environmental conditions affect the development of the fetus. In the present study, we investigated the effects of exposure to music and noise during pregnancy on neurogenesis and thickness in the motor and somatosensory cortex of rat pups.
Methods: The pregnant rats in the music-applied group were exposed to 65 dB of comfortable music for 1 hour, once per day, from the 15th day of pregnancy until delivery. The pregnant rats in the noise-applied group were exposed to 95 dB of sound from a supersonic sound machine for 1 hour, once per day, from the 15th day of pregnancy until delivery. After birth, the offspring were left undisturbed together with their mother. The rat pups were sacrificed at 21 days after birth.
Results: Exposure to music during pregnancy increased neurogenesis in the motor and somatosensory cortex of rat pups. In contrast, rat pups exposed to noise during pregnancy showed decreased neurogenesis and thickness in the motor and somatosensory cortex.
Conclusions: Our study suggests that music and noise during the developmental period are important factors influencing brain development and urogenital disorders.
C1 [Kim, Chang-Hee; Lee, Sang-Chul; Chung, Kyung-Jin; Kim, Khae-Hawn] Gachon Univ, Gil Med Ctr, Dept Urol, Inchon 405760, South Korea.
[Shin, Je Wook] Gachon Univ Med & Sci, Dept Urol, Inchon, South Korea.
[Lee, Shin-Ho; Shin, Mal-Soon; Kim, Chang-Ju] Kyung Hee Univ, Sch Med, Dept Physiol, Seoul, South Korea.
[Baek, Sang-Bin] Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Psychiat, Kangnung, South Korea.
[Sung, Yun-Hee] Kyungnam Univ, Dept Phys Therapy, Chang Won, South Korea.
RP Kim, KH (reprint author), Gachon Univ, Gil Med Ctr, Dept Urol, 21 Namdong Daero 774beon Gil, Inchon 405760, South Korea.
EM kimcho99@gilhospital.com
FU National Research Foundation of Korea Grant - Korean Government (MEST)
[NRF-2010-0022895]
FX This work was supported by the National Research Foundation of Korea
Grant funded by the Korean Government (MEST) (NRF-2010-0022895).
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NR 32
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Z9 0
PU KOREAN CONTINENCE SOC
PI YEONGOTONG-GU
PA DEPT UROLOGY, AJOU UNIV COLL MEDICINE, SAN 5 WONCHEN-DONG,
YEONGOTONG-GU, SUWON 443-721, SOUTH KOREA
SN 2093-4777
EI 2093-6931
J9 INT NEUROUROL J
JI Int. Neurourol. J.
PD SEP
PY 2013
VL 17
IS 3
BP 107
EP 113
DI 10.5213/inj.2013.17.3.107
PG 7
WC Urology & Nephrology
SC Urology & Nephrology
GA AM0YN
UT WOS:000339573700003
ER
PT J
AU Piz, L
Maremrnani, AGI
Rovai, L
Bacciardi, S
Rugani, F
Maremmani, I
AF Piz, Luigi
Maremrnani, Angelo Giovanni Icro
Rovai, Luca
Bacciardi, Silvia
Rugani, Fabio
Maremmani, Icro
TI Successful long-term (3-year) treatment of gambling with naltrexone. A
case report
SO HEROIN ADDICTION AND RELATED CLINICAL PROBLEMS
LA English
DT Article
DE Pathological Gambling; Naltrexone; Long-term outcome
ID HIGH-DOSE NALTREXONE; ALCOHOL DEPENDENCE; DOUBLE-BLIND; ANTAGONIST
NALTREXONE; BULIMIA; DYSPHORIA; COCAINE; PREDICTORS; BLOCKADE; GAMBLERS
AB Pathological gambling (PG) is classified as an impulse control disorder in the Diagnosis and Statistical Manual of Mental Disorder (DSM-IV-TR). There is still no properly validated pharmacotherapeutic treatment of PG. The involvement of the mu-opioid system in reward processes leads to the hypothesis that opioid antagonists have an impact on addictive behaviours. In reality, opioid antagonists have been used not only in substance abuse illnesses (narcotics, alcohol), but also in a variety of psychiatric conditions, including anorexia nervosa, bulimia, schizophrenia, self-injurious behaviour autism, obsessive-compulsive disorder, Tourette's disease and trichotillomania. We present a case report in which an Italian patient affected by pathological gambling was successfully given long-term treatment with naltrexone. Controlled studies on opiate antagonists from the literature have already shown positive results. This case report confirms these data, but the present innovative finding is, for the first time, focused on the long-term outcome of treatment without side-effects. The patient has, in fact, taken her medication for 3 years, and so far she has never relapsed into gambling.
C1 [Piz, Luigi; Maremrnani, Angelo Giovanni Icro; Rovai, Luca; Bacciardi, Silvia; Rugani, Fabio; Maremmani, Icro] Univ Pisa, Santa Chiara Univ Hosp, Dept Neurosci, Vincent P Dole Dual Diag Unit, I-56100 Pisa, Italy.
[Maremmani, Icro] G De Lisio Inst Behav Sci Pisa, Pisa, Italy.
[Maremrnani, Angelo Giovanni Icro; Maremmani, Icro] Assoc Applicat Neurosci Knowledge Social Aims AU, Lucca, Italy.
RP Piz, L (reprint author), Univ Pisa, Santa Chiara Univ Hosp, Dept Neurosci, Vincent P Dole Dual Diag Unit, Via Roma 67, I-56100 Pisa, Italy.
EM pizluigi@gmail.com
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NR 52
TC 0
Z9 0
PU PACINI EDITORE
PI PISA
PA VIA DELLA GHERARDESCA-ZONA INDUSTRIALE OSPEDALETTO, 56121 PISA, ITALY
SN 1592-1638
J9 HEROIN ADDICT REL CL
JI Heroin Addict. Relat. Clin. Probl.
PD SEP
PY 2013
VL 15
IS 3
BP 47
EP 54
PG 8
WC Substance Abuse
SC Substance Abuse
GA AL6GK
UT WOS:000339230400006
ER
PT J
AU Miller, S
AF Miller, Sarah
TI First autism whole-genome sequencing study offers a whole new level of
insight
SO PERSONALIZED MEDICINE
LA English
DT News Item
CR Jiang YH, 2013, AM J HUM GENET, V93, P249, DOI 10.1016/j.ajhg.2013.06.012
NR 1
TC 0
Z9 0
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1741-0541
EI 1744-828X
J9 PERS MED
JI Pers. Med.
PD SEP
PY 2013
VL 10
IS 7
BP 628
EP 628
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA AI8PX
UT WOS:000337184100003
ER
PT J
AU Carneiro, MFH
Morais, C
Barbosa, F
Gobe, GC
AF Hornos Carneiro, Maria Fernanda
Morais, Christudas
Barbosa, Fernando, Jr.
Gobe, Glenda Carolyn
TI Thimerosal in childhood vaccines contributes to accumulating mercury
toxicity in the kidney
SO TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
LA English
DT Article
DE thimerosal; ethyl mercury; kidney; apoptosis; oxidative stress
ID CHLORIDE-INDUCED APOPTOSIS; RENAL TUBULAR CELLS; BLOOD-BRAIN-BARRIER;
INORGANIC MERCURY; OXIDATIVE STRESS; IN-VITRO; LIPID-PEROXIDATION;
RAT-KIDNEY; MITOCHONDRIAL DYSFUNCTION; INDUCED NEPHROTOXICITY
AB Mercury (Hg) is a hazardous chemical that accumulates in many cells and tissues, thereby producing toxicity. The kidney is a key target organ for Hg accumulation and toxicity. The contributing factors to Hg accumulation in humans include: (1) elemental and inorganic Hg exposure, often occurring by inhalation of Hg vapors; (2) exposure to methyl Hg (meHg), for example, through contaminated seafood; and (3) exposure to ethyl mercury (etHg) via thimerosal-containing vaccines. Systematic investigations on the toxic effects of etHg/thimerosal on the nervous system were carried out, and etHg/thimerosal emerged as a possible risk factor for autism and other neurodevelopmental disorders. There is, however, little known about the mechanisms and molecular interactions underlying toxicity of etHg/thimerosal in the kidney, which is the focus of the current review. Susceptible populations such as infants, pregnant women, and the elderly are exposed to etHg through thimerosal-containing vaccines, and in-depth study of the potential adverse effects on the kidney is needed. In general, toxicity occurring in association with different forms of Hg is related to: intracellular thiol metabolism and oxidative stress reactions; mitochondrial function; intracellular distribution and build-up of calcium; apoptosis; expression of stress proteins; and also interaction with the cytoskeleton. Available evidence for the etHg-induced toxicity in the kidney was examined, and the main mechanisms and molecular interactions of cytotoxicity of etHg/thimerosal exposure in kidney described. Such accumulating knowledge may help to indicate molecular pathways that, if modulated, may better handle Hg-mediated toxicity.
C1 [Hornos Carneiro, Maria Fernanda; Morais, Christudas; Gobe, Glenda Carolyn] Univ Queensland, Sch Med, Translat Res Inst, Ctr Kidney Dis Res, Brisbane, Qld, Australia.
[Hornos Carneiro, Maria Fernanda; Barbosa, Fernando, Jr.] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Lab Toxicol & Essencialidade Met, BR-14049 Ribeirao Preto, SP, Brazil.
RP Gobe, GC (reprint author), Univ Queensland, Sch Med, Translat Res Inst, Ctr Kidney Dis Res, Brisbane, Qld, Australia.
EM g.gobe@uq.edu.au
RI Barbosa, Fernando/C-6929-2012; Carneiro, Maria Fernanda/E-6870-2014;
Gobe, Glenda/G-2315-2010
OI Barbosa, Fernando/0000-0002-2498-0619; Carneiro, Maria
Fernanda/0000-0001-7041-6923;
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
FX The authors are grateful to Conselho Nacional de Desenvolvimento
Cientifico e Tecnologico (CNPq) and Coordenacao de Aperfeicoamento de
Pessoal de Nivel Superior (CAPES) for financial support and fellowships.
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NR 196
TC 1
Z9 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0277-2248
EI 1029-0486
J9 TOXICOL ENVIRON CHEM
JI Toxicol Environ. Chem.
PD SEP 1
PY 2013
VL 95
IS 8
BP 1424
EP 1447
DI 10.1080/02772248.2013.877246
PG 24
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA AB6WB
UT WOS:000331929100018
ER
PT J
AU Huang, A
Seshadri, K
Matthews, TA
Ostfeld, BM
AF Huang, Angela
Seshadri, Kapila
Matthews, Tara Anne
Ostfeld, Barbara M.
TI Parental Perspectives on Use, Benefits, and Physician Knowledge of
Complementary and Alternative Medicine in Children with Autistic
Disorder and Attention-Deficit/Hyperactivity Disorder
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID DEFICIT HYPERACTIVITY DISORDER; RANDOMIZED CONTROLLED-TRIAL; SPECTRUM
DISORDERS; CHILDHOOD ATTENTION; THERAPIES; PEDIATRICS; PROTOCOL; ADHD;
CAM
AB Background: Complementary and alternative medicine (CAM) use appears to be increasing in children with developmental disorders. However, it is not clear whether parents perceive their healthcare providers as resources who are knowledgeable about CAM therapies and are interested in further developing their knowledge.
Objectives: (1) To establish and compare use of, and perceived satisfaction with, traditional medicine and CAM in children with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs) and (2) to assess parental perceptions of physician knowledge of CAM and physician interest in continuing education about CAM for the two groups of parents.
Methods: Families of children with a diagnosis of ADHD or ASD were surveyed regarding the frequency of use of traditional treatment and CAM, parental perceptions of the helpfulness of each therapy, parental perceptions regarding physicians' knowledge level about CAM, and physician interest in continuing education.
Results: Thirty-six percent (n = 135) of 378 surveys were returned: 41 contained a diagnosis of ADHD and 22 of ASD. Traditional therapies were used by 98% of children with ADHD and 100% of those with ASD. Perceived helpfulness of medication was 92% for children with ADHD and 60% for children with ASD (p < 0.05). CAM was used for 19.5% of children with ADHD and 82% of children with ASD. Perceived satisfaction for any form of CAM in the children with ADHD was at an individual patient level. Satisfaction for two of the most commonly used CAM treatments in children with ASD ranged from 50% to 78%. In children with ASD (the diagnostic group with the highest use of and satisfaction with CAM), physician's perceived knowledge of CAM was lower (14% versus 38%; p < 0.05), as was perceptions of the physician's interest in learning more (p < 0.05).
Conclusion: CAM use is significant, especially in children with ASD. Physicians are not perceived as a knowledgeable resource.
C1 [Huang, Angela] Texas Tech Univ Hlth Sci Ctr Sch Med Amarillo, Div Dev Behav Pediat, Dept Pediat, Amarillo, TX USA.
[Seshadri, Kapila; Matthews, Tara Anne; Ostfeld, Barbara M.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pediat, New Brunswick, NJ 08903 USA.
RP Seshadri, K (reprint author), Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pediat, Inst Child Hlth, 89 French St, New Brunswick, NJ 08903 USA.
EM seshadka@umdnj.edu
CR Aickin M, 2010, J ALTERN COMPLEM MED, V16, P1, DOI 10.1089/acm.2009.0718
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NR 18
TC 1
Z9 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD SEP
PY 2013
VL 19
IS 9
BP 746
EP 750
DI 10.1089/acm.2012.0640
PG 5
WC Integrative & Complementary Medicine
SC Integrative & Complementary Medicine
GA 300IN
UT WOS:000330457700003
PM 23621389
ER
PT J
AU Graf-Myles, J
Farmer, C
Thurm, A
Royster, C
Kahn, P
Soskey, L
Rothschild, L
Swedo, S
AF Graf-Myles, Jennifer
Farmer, Cristan
Thurm, Audrey
Royster, Caitlin
Kahn, Phoebe
Soskey, Laura
Rothschild, Leah
Swedo, Susan
TI Dietary Adequacy of Children with Autism Compared with Controls and the
Impact of Restricted Diet
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE autism; diet; nutrition; healthy eating index; gluten-free; casein-free
ID TYPICALLY DEVELOPING-CHILDREN; HEALTHY EATING INDEX-2005;
VITAMIN-A-DEFICIENCY; SPECTRUM DISORDERS; FOOD SELECTIVITY;
PRESCHOOL-CHILDREN; NUTRIENT INTAKE; YOUNG-CHILDREN; BEHAVIORS;
NUTRITION
AB Objective: Children with autism (AUT) may consume a restricted diet relative to typical peers, whether due to therapeutic measures or sensory sensitivities. The objective of this study was to compare children with AUT with both typically developing (TYP) and developmentally delayed children on nutrient and food group intake and overall diet quality and to evaluate the impact of diet restriction. Methods: Three-day food records and interview information were analyzed from 69 children with AUT, 14 children with developmental delay, and 37 TYP children, drawn from a larger longitudinal study. Results: Children with AUT did not differ significantly from children with other developmental delays on any dietary measures. Although there were differences in the average intake of some nutrients between AUT and typical controls, only calcium and dairy were also less likely to be consumed in adequate amounts by the AUT group. Intentional diet restriction accounted for most of the differences between AUT and typical controls. On average, all groups had inadequate fiber, vitamin D, and vegetable intake. Inadequate intake of folate, grains, and dairy was noted for the AUT subgroup with intentional diet restrictions. Children in the AUT group not following a restricted diet received significantly worse Healthy Eating Index-2005 scores than those following a restricted diet and typical controls. These differences were not nutritionally significant. Conclusions: When evaluating nutritional adequacy of children with AUT, special consideration should be given to calcium, folate, dairy, and grains. Diets of all children with AUT should be evaluated for idiosyncratic deficiencies because of unique dietary patterns.
C1 [Graf-Myles, Jennifer; Royster, Caitlin] NIH, Dept Nutr, Ctr Clin, Bethesda, MD 20892 USA.
[Farmer, Cristan; Thurm, Audrey; Kahn, Phoebe; Soskey, Laura; Rothschild, Leah; Swedo, Susan] NIMH, Pediat & Dev Neurosci Branch, NIH, Bethesda, MD 20892 USA.
RP Graf-Myles, J (reprint author), NIH, Dept Nutr, Room B2-2426,Bldg 10,10 Ctr Dr, Bethesda, MD 20892 USA.
EM mylesjg@cc.nih.gov
FU National Institute of Mental Health of the National Institutes of Health
[NCT00298246, 06-M-0102]
FX This work was supported by the Intramural Program of the National
Institute of Mental Health of the National Institutes of Health,
NCT00298246, 06-M-0102.
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NR 43
TC 4
Z9 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD SEP
PY 2013
VL 34
IS 7
BP 449
EP 459
PG 11
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 298XW
UT WOS:000330359000001
PM 24042076
ER
PT J
AU Russ, SA
Kenney, MK
Kogan, MD
AF Russ, Shirley A.
Kenney, Mary K.
Kogan, Michael D.
TI Hearing Difficulties in Children with Special Health Care Needs
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE CSHCN; hearing loss; learning difficulties; hearing aids
ID DOWN-SYNDROME; SPECTRUM DISORDER; CEREBRAL-PALSY; IMPAIRMENT;
PREVALENCE; EPIDEMIOLOGY; DIAGNOSIS; OUTCOMES; AUTISM
AB Objective: To determine characteristics of children with special health care needs (CSHCN) with hearing difficulties including patterns of hearing aid use, comorbidity, and social and communication function. Methods: Bivariate and multivariable analysis of cross-sectional data on 40,723 children aged from birth to 17 years from the 2005-2006 National Survey of Children with Special Health Care Needs, including 1,982 (5%) with parent-reported hearing difficulties. Results: Among CSHCN, 383 (1%) used hearing aids, representing 20% of those with reported hearing difficulties. Odds of hearing aid use increased with age, primary language other than English, and lower income. More than half (58%) of the aided children reported hearing difficulties even with their aid. Among CSHCN with cerebral palsy, 13% had reported hearing difficulties and 3% used hearing aids. Equivalent figures for children with Down syndrome were 24% and 4%, mental retardation/developmental delay 12% and 5%, and autism spectrum disorder 9% and 2%. Overall, two-thirds of CSHCN with hearing difficulties had one or more sensory/developmental comorbidities; CSHCN with both hearing difficulties and a sensory/developmental comorbidity had highest odds of learning difficulties, speaking/communication difficulties, feeling anxious/depressed, acting out/bullying, and difficulty making friends. CSHCN with hearing difficulties alone, or sensory/developmental conditions alone had intermediate odds, after socio-demographic adjustment. Conclusions: Sensory/developmental comorbidities are common among CSHCN with hearing difficulties, and they are associated with higher odds of poorer social, communication, and educational function. Services for CSHCN must be equipped to address a range of hearing difficulties as well as sensory/developmental comorbidities and to improve social/emotional functioning as well as learning and communication.
C1 [Russ, Shirley A.] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Ctr Healthier Children Families & Communitie, Los Angeles, CA 90095 USA.
[Kenney, Mary K.; Kogan, Michael D.] Maternal & Child Hlth Bur, US Dept HHS, Washington, DC USA.
RP Russ, SA (reprint author), UCLA Ctr Healthier Children Families & Communitie, 10990 Wilshire Blvd,Suite 900, Los Angeles, CA 90024 USA.
EM shirlyruss@aol.com
CR Busa J, 2007, PEDIATRICS, V120, P898, DOI 10.1542/peds.2007-2333
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NR 29
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD SEP
PY 2013
VL 34
IS 7
BP 478
EP 485
PG 8
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 298XW
UT WOS:000330359000004
PM 24042079
ER
PT J
AU Coury, DL
AF Coury, Daniel L.
TI DSM-5 and Autism Spectrum Disorders: Implications for Families and
Clinicians
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Editorial Material
DE autism spectrum disorders; DSM-5; social communication disorder;
advocacy; clinical practice; special education
ID CRITERIA
AB Changes in the criteria for autism spectrum disorders in the new Diagnostic and Statistical Manual, fifth edition (DSM-5), have raised concerns among both professionals and the public. This commentary reviews these changes and their implications for families and clinicians.
C1 [Coury, Daniel L.] Nationwide Childrens Hosp, Dept Pediat, Div Dev & Behav Pediat, Columbus, OH USA.
RP Coury, DL (reprint author), 700 Childrens Dr,Timken G-350, Columbus, OH 43205 USA.
EM daniel.coury@nationwidechildrens.org
FU Autism Speaks; US Department of Health and Human Services, Health
Resources and Services Administration, Maternal and Child Health
Research Program [UA3 MC 11054]; SynapDx Corporation
FX The author reports the following support: Supported in part by Autism
Speaks and by cooperative agreement UA3 MC 11054 through the US
Department of Health and Human Services, Health Resources and Services
Administration, Maternal and Child Health Research Program to the
Massachusetts General Hospital. Dr. D. L. Coury has also received grant
support from SynapDx Corporation.
CR Frazier TW, 2012, J AM ACAD CHILD PSY, V51, P28, DOI 10.1016/j.jaac.2011.09.021
Gibson J, 2013, J CHILD PSYCHOL PSYC, V54, P1186, DOI 10.1111/jcpp.12079
Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148
Mandy WPL, 2012, J AM ACAD CHILD PSY, V51, P41, DOI 10.1016/j.jaac.2011.10.013
Williams D, 2008, PSYCHOL BULL, V134, P944, DOI [10.1037/a0013743, 10.1037/0013743]
NR 5
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD SEP
PY 2013
VL 34
IS 7
BP 494
EP 496
PG 3
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 298XW
UT WOS:000330359000006
PM 24042080
ER
PT J
AU Berry-Kravis, E
Hessl, D
Abbeduto, L
Reiss, AL
Beckel-Mitchener, A
Urv, TK
AF Berry-Kravis, Elizabeth
Hessl, David
Abbeduto, Leonard
Reiss, Allan L.
Beckel-Mitchener, Andrea
Urv, Tiina K.
CA Outcome Measures Working Grp
TI Outcome Measures for Clinical Trials in Fragile X Syndrome
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE fragile X syndrome; clinical trials; outcome measures; intellectual
disability
ID AUTISM SPECTRUM DISORDER; ABERRANT BEHAVIOR CHECKLIST; DOWN-SYNDROME;
WORKING-MEMORY; EXPRESSIVE LANGUAGE; MENTAL-RETARDATION; DOUBLE-BLIND;
DEVELOPMENTAL-DISABILITIES; REPETITIVE BEHAVIOR; ATTENTION DEFICITS
AB Objective: Progress in basic neuroscience has led to identification of molecular targets for treatment in fragile X syndrome (FXS) and other neurodevelopmental disorders; however, there is a gap in translation to targeted therapies in humans. One major obstacle to the demonstration of efficacy in human trials has been the lack of generally accepted endpoints to assess improvement in function in individuals with FXS. To address this problem, the National Institutes of Health convened a meeting of leading scientists and clinicians with the goal of identifying and standardizing outcome measures for use as potential endpoints in clinical trials in FXS. Methods: Participants in the meeting included FXS experts, experts in the design and implementation of clinical trials and measure development, and representatives from advocacy groups, industry, and federal agencies. Results: The group generated recommendations for optimal outcome measures in cognitive, behavioral, and biomarker/medical domains, including additional testing and validation of existing measures and development of new measures in areas of need. Although no one endpoint or set of endpoints could be identified that met all criteria as an optimal measure, recommendations are presented in this report. Conclusion: The report is expected to guide the selection of measures in clinical trials and lead to the use of a more consistent battery of measures across trials. Furthermore, this will help to direct research toward gaps in the development of validated FXS-specific outcome measures and to assist with interpretation of clinical trial data by creating templates for measurement of treatment efficacy.
C1 [Berry-Kravis, Elizabeth] Rush Univ, Med Ctr, Dept Pediat, Chicago, IL 60612 USA.
[Berry-Kravis, Elizabeth] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.
[Berry-Kravis, Elizabeth] Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA.
[Hessl, David; Abbeduto, Leonard] Univ Calif Davis, Sch Med, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
[Hessl, David; Abbeduto, Leonard] Univ Calif Davis, Med Ctr, MIND Inst, Sacramento, CA 95817 USA.
[Reiss, Allan L.] Stanford Univ, Sch Med, Ctr Interdisciplinary Brain Sci Res, Stanford, CA 94305 USA.
[Reiss, Allan L.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
[Reiss, Allan L.] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA.
[Reiss, Allan L.] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA.
[Beckel-Mitchener, Andrea] NIMH, NIH, Bethesda, MD 20892 USA.
[Urv, Tiina K.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
RP Berry-Kravis, E (reprint author), Rush Univ, Med Ctr, 1725 West Harrison,Suite 718, Chicago, IL 60612 USA.
EM elizabeth_m_berry-kravis@rush.edu
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development; Office of Rare Disease Research; National Institute of
Mental Health; National Institute of Neurological Disorders and Stroke
FX The Fragile X Outcome Measures Working Group meeting was supported by
the Eunice Kennedy Shriver National Institute of Child Health and Human
Development, the Office of Rare Disease Research, the National Institute
of Mental Health, and the National Institute of Neurological Disorders
and Stroke. The authors thank Dr. Shaguna Mathur for her assistance with
manuscript formatting and submission.
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NR 124
TC 16
Z9 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD SEP
PY 2013
VL 34
IS 7
BP 508
EP 522
PG 15
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 298XW
UT WOS:000330359000008
PM 24042082
ER
PT J
AU Galligan, MG
Feinstein, C
Sulkes, SS
Bisagno, JM
Stein, MT
AF Galligan, Meghan G.
Feinstein, Carl
Sulkes, Stephen S.
Bisagno, Joan M.
Stein, Martin T.
TI Asperger Syndrome and DSM-5: A Dilemma for a College Freshman
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Editorial Material
AB CASE: Angela is an 18-year-old college freshman who made an appointment with her pediatrician because of academic and social difficulties at college. She was diagnosed with Asperger disorder at age 6 based on difficulties relating to adults and peers, perseverative patterns of interest, and normal language development.
She received special education services in middle school to help follow directions and complete assignments. She reports feeling very isolated during this time. In freshman year of high school, she insisted on discontinuing special education and managed with weekly private individual psychotherapy.
In sophomore year, Angela learned strategies to get additional help from her teachers about assignments, and her grades improved. Socially, she formed a close friendship with a classmate who was also on the autistic spectrum, and she found a group of friends through this individual. As a senior with an upward grade trajectory and good SAT scores, she was admitted to a competitive 4-year college. In a precollege consult 6 months ago, she was anxious about fitting in.
Angela began college classes without accommodations, but she now describes a challenging semester. She has not made many friends. She finds her courses difficult and does not fully understand assignments. She believes her peers dislike her. She thinks she would benefit from receiving note-taking and other services and asks you to document her disability for the college so that she might obtain accommodations.
You point out that the DSM-5 eliminates the Asperger category. Angela is concerned. She does not believe that her profile is consistent with autism spectrum disorder, and she fears that being labeled as autistic will be prejudicial at school. Yet she is worried about retaining eligibility for services on the basis of a disability. How do you counsel her?
C1 [Galligan, Meghan G.] Stanford Univ, Sch Med, Arts Humanities & Med Program, Stanford, CA 94305 USA.
[Feinstein, Carl] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
[Sulkes, Stephen S.] Univ Rochester, Med Ctr, Golisano Childrens Hosp, Div Neurodev & Behav Pediat, Rochester, NY 14642 USA.
[Bisagno, Joan M.] Stanford Univ, Sch Med, Off Accessible Educ, Stanford, CA 94305 USA.
[Bisagno, Joan M.] Stanford Univ, Sch Med, Schwab Learning Ctr, Stanford, CA 94305 USA.
[Stein, Martin T.] Univ Calif San Diego, Sch Med, Div Acad Gen Pediat Dev Pediat & Community Hlth, San Diego, CA 92103 USA.
RP Galligan, MG (reprint author), Stanford Univ, Sch Med, Arts Humanities & Med Program, Stanford, CA 94305 USA.
CR Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI 10.1017/CBO9780511526770.002
Kanner L, 1943, NERV CHILD, V2, P217
NR 2
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD SEP
PY 2013
VL 34
IS 7
BP 529
EP 532
PG 4
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA 298XW
UT WOS:000330359000010
PM 24042084
ER
PT J
AU Bartl-Pokorny, KD
Pokorny, F
Bolte, S
Langmann, A
Falck-Ytter, T
Wolin, T
Einspieler, C
Sigafoos, J
Marschik, PB
AF Bartl-Pokorny, K. D.
Pokorny, F.
Boelte, S.
Langmann, A.
Falck-Ytter, T.
Wolin, T.
Einspieler, C.
Sigafoos, J.
Marschik, P. B.
TI Eye Tracking in Basic Research and Clinical Practice
SO KLINISCHE NEUROPHYSIOLOGIE
LA German
DT Article
DE autism; autism spectrum disorders; dyslexia; eye tracking; dyslexia
ID AUTISM SPECTRUM DISORDERS; DEVELOPMENTAL DYSLEXIA; PRINT ADVERTISEMENTS;
RECURRENCE RISK; MOVEMENTS; CHILDREN; AGE; BEHAVIOR; LOOKING; TWIN
AB Eye tracking is a non-invasive technique based on infrared video technology that is used to analyse eye movements. Such analyses might provide insights into perceptual and cognitive capacities. It is a method widely used in various disciplines, such as ophthalmology, neurology, psychiatry and neuropsychology for basic science, but also clinical practice. For example, recent studies on children who were later diagnosed with autism spectrum disorders revealed early abnormal eye movement patterns in socio-communicative settings; children with dyslexia appeared also to have peculiar eye movement patterns, expressed in longer fixation durations and smaller saccades while reading. Current research using eye tracking systems in combination with neurophysiological and brain imaging techniques will add to a better understanding of cognitive, linguistic and socio-communicative development and in the near future possibly also lead to a broader clinical application of this method.
C1 [Bartl-Pokorny, K. D.; Pokorny, F.; Wolin, T.; Einspieler, C.; Marschik, P. B.] Med Univ Graz, Zentrum Physiol Med, Inst Physiol, IN Spired, A-8010 Graz, Austria.
[Boelte, S.; Falck-Ytter, T.] Karolinska Inst, Karolinska Inst Ctr Neurodev Disorders KIND, Dept Womens & Childrens Hlth, S-10401 Stockholm, Sweden.
[Langmann, A.] Graz Univ, Augenklin Med, Ambulanz Schielen Kinderophthalmol & Rehabil Sehb, A-8010 Graz, Austria.
[Falck-Ytter, T.] Uppsala Univ, Dept Physiol, Uppsala, Sweden.
[Sigafoos, J.] Victoria Univ Wellington, Sch Educ Psychol & Pedag, Wellington, New Zealand.
RP Marschik, PB (reprint author), Med Univ Graz, Zentrum Physiol Med, Inst Physiol, Harrachgasse 21-5, A-8010 Graz, Austria.
EM peter.marschik@medunigraz.at
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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World Health Organisation, 1992, ICD 10 CLASS MENT BE
Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x
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NR 62
TC 0
Z9 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 1434-0275
EI 1439-4081
J9 KLIN NEUROPHYSIOL
JI Klin. Neurophysiol.
PD SEP
PY 2013
VL 44
IS 3
BP 193
EP 198
DI 10.1055/s-0033-1343458
PG 6
WC Clinical Neurology; Neuroimaging; Physiology
SC Neurosciences & Neurology; Physiology
GA 301GY
UT WOS:000330522000004
ER
PT J
AU Christensen, J
Gronborg, TK
Sorensen, MJ
Schendel, D
Parner, ET
Pedersen, LH
Vestergaard, M
AF Christensen, Jakob
Gronborg, Therese Koops
Sorensen, Merete Juul
Schendel, Diana
Parner, Erik Thorlund
Pedersen, Lars Henning
Vestergaard, Mogens
TI Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and
Childhood Autism EDITORIAL COMMENT
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
ID OUTCOMES
C1 [Christensen, Jakob] Aarhus Univ Hosp, Dept Neurol, DK-8000 Aarhus, Denmark.
[Christensen, Jakob] Aarhus Univ Hosp, Dept Clin Pharmacol, DK-8000 Aarhus, Denmark.
[Gronborg, Therese Koops; Parner, Erik Thorlund] Aarhus Univ, Dept Biostat, Aarhus, Denmark.
[Pedersen, Lars Henning] Aarhus Univ, Dept Epidemiol, Aarhus, Denmark.
[Pedersen, Lars Henning] Aarhus Univ, Inst Publ Hlth, Inst Clin Med, Dept Obstet & Gynaecol, Aarhus, Denmark.
[Vestergaard, Mogens] Aarhus Univ, Inst Publ Hlth, Res Unit, Aarhus, Denmark.
[Vestergaard, Mogens] Aarhus Univ, Inst Publ Hlth, Sect Gen Practice, Aarhus, Denmark.
[Sorensen, Merete Juul] Aarhus Univ Hosp, Reg Ctr Child & Adolescent Psychiat, Risskov, Denmark.
[Schendel, Diana] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Christensen, J (reprint author), Aarhus Univ Hosp, Dept Neurol, DK-8000 Aarhus, Denmark.
CR 2008, EPILEPSY RES, V81, P1
2013, LANCET NEUROL, V12, P244
2007, PEDIATRICS, V119, pE1040
2007, ANN REV PUBLIC HLTH, V28, P235
2012, AM J MED GENET, V158, P2071
NR 5
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD SEP
PY 2013
VL 68
IS 9
BP 613
EP 614
PG 2
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 301DM
UT WOS:000330513000003
ER
PT J
AU Armstrong, DC
Redman-Bentley, D
Wardell, M
AF Armstrong, Dayle C.
Redman-Bentley, Donna
Wardell, Mary
TI Differences in Function Among Children With Sensory Processing
Disorders, Physical Disabilities, and Typical Development
SO PEDIATRIC PHYSICAL THERAPY
LA English
DT Article
DE activities of daily living; child; child development; child development
disorders; disability evaluation; female; male; motor skills
disorders/diagnosis; neuropsychological tests; psychomotor disorders;
sensory disorders
ID YOUNG-CHILDREN; PEDIATRIC EVALUATION; MOTOR DEVELOPMENT; AUTISM;
PERFORMANCE; INVENTORY; DELAYS
AB Purpose: To examine the capability and performance of children with sensory processing disorders (SPD) compared with children who are developing typically and those with physical disabilities (PD). Methods: Participants included parents/caregivers of 81 children ranging in age from 1 to 7.3 years; 57% were boys. The child's therapist interviewed the parents using the Pediatric Evaluation of Disability Inventory (PEDI) to measure functional performance. Results: Children with SPD demonstrated significant differences from children in the other groups in functional skills and caregiver assistance within 3 domains (self-care, mobility, social function). Conclusions: The PEDI can be used to (1) identify functional delays in young children with SPD, which can affect participation in age-appropriate self-care, mobility, and social skills, and (2) determine appropriate referrals for early intervention.
C1 [Armstrong, Dayle C.] Western Univ Hlth Sci, Dept Phys Therapy Educ, Pomona, CA 91766 USA.
[Redman-Bentley, Donna] Western Univ Hlth Sci, Coll Allied Hlth Profess, Pomona, CA 91766 USA.
[Wardell, Mary] Miller Childrens Hosp Long Beach, Long Beach, CA USA.
RP Armstrong, DC (reprint author), Western Univ Hlth Sci, Dept Phys Therapy Educ, 309 E Second St, Pomona, CA 91766 USA.
EM darmstron@westernu.edu
CR Ahn RR, 2004, AM J OCCUP THER, V58, P287
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NR 23
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0898-5669
EI 1538-005X
J9 PEDIATR PHYS THER
JI Pediatr. Phys. Ther.
PD FAL
PY 2013
VL 25
IS 3
BP 315
EP 321
DI 10.1097/PEP.0b013e3182980cd4
PG 7
WC Pediatrics; Rehabilitation
SC Pediatrics; Rehabilitation
GA 300FW
UT WOS:000330450800016
PM 23797404
ER
PT J
AU Ishitobi, M
Kosaka, H
Takahashi, T
Yatuga, C
Asano, M
Tanaka, Y
Ueno, K
Okazaki, R
Omori, M
Hiratani, M
Tomoda, A
Wada, Y
AF Ishitobi, Makoto
Kosaka, Hirotaka
Takahashi, Tetsuya
Yatuga, Chiho
Asano, Mizuki
Tanaka, Yuji
Ueno, Kanji
Okazaki, Ryoko
Omori, Masao
Hiratani, Michio
Tomoda, Akemi
Wada, Yuji
TI Effectiveness and Tolerability of Switching to Aripiprazole From
Risperidone in Subjects With Autism Spectrum Disorders: A Prospective
Open-Label Study
SO CLINICAL NEUROPHARMACOLOGY
LA English
DT Review
DE autism spectrum disorders (ASDs); aripiprazole; risperidone;
tolerability issues; switching
ID PERVASIVE DEVELOPMENTAL DISORDERS; ABERRANT BEHAVIOR CHECKLIST;
PHARMACOLOGICAL-TREATMENT; RATING-SCALE; CHILDREN; ADOLESCENTS;
IRRITABILITY; HYPERPROLACTINEMIA; MECHANISM; EFFICACY
AB Background: Subjects with autism spectrum disorders (ASDs) often exhibit behavioral symptoms such as aggressiveness and irritability. The purpose of this study was to examine the efficacy and the tolerability of aripiprazole switched from risperidone in children and adolescents with ASD.
Methods: This prospective, 12-week, open-label study included 9 male subjects with ASD (age range, 9-22 years; mean +/- SD age, 14.8 +/- 4.0 years) followed up for 12 weeks after switching to aripiprazole from risperidone. The primary outcome measures were the Clinical Global Impression-Improvement scales and the irritability subscale of the Aberrant Behavior Checklist.
Results: The mean +/- SD maintenance dosages of risperidone and aripiprazole were 0.6 +/- 0.4 mg/d and 4.8 +/- 4.0 mg/d, respectively. The mean +/- SD scores of the irritability subscale of the Aberrant Behavior Checklist before switching to aripiprazole (baseline) and 12 weeks after switching to aripiprazole (end point) were 14.8 +/- 7.6 and 13.1 +/- 8.0, respectively. The mean +/- SD Clinical Global Impression-Improvement score, a comparison from baseline to end point, was 2.4 +/- 0.7. Mild somnolence was observed only in 1 subject. No significant changes in vital signs, weight, electrocardiogram, or laboratory measures occurred during switching to aripiprazole. Serum prolactin levels decreased significantly from 17.3 +/- 9.4 ng/mL (baseline) to 2.3 +/- 1.7 ng/mL (end point).
Conclusions: The results show that aripiprazole might be generally well tolerated and might constitute an alternative treatment of subjects with ASD who experience poor efficacy or tolerability issues with risperidone treatment. Additional long-term controlled studies are needed to evaluate the efficacy and the safety of switching to aripiprazole from other antipsychotics in subjects with ASD.
C1 [Ishitobi, Makoto; Kosaka, Hirotaka; Takahashi, Tetsuya; Asano, Mizuki; Tanaka, Yuji; Ueno, Kanji; Okazaki, Ryoko; Wada, Yuji] Univ Fukui, Dept Neuropsychiat, Fukui 910, Japan.
[Ishitobi, Makoto; Hiratani, Michio] Hiratani Child Dev Clin, Fukui, Japan.
[Kosaka, Hirotaka; Yatuga, Chiho; Asano, Mizuki; Wada, Yuji] Univ Fukui, Res Ctr Child Mental Dev, Fukui 910, Japan.
[Omori, Masao] Fukui Prefectural Univ, Fac Nursing & Social Welf Sci, Fukui, Japan.
RP Ishitobi, M (reprint author), Univ Fukui, Dept Neuropsychiat, 23-3 Matsuokashimoaizuki, Eiheiji, Fukui 9101193, Japan.
EM mak1977019@yahoo.co.jp
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NR 35
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-5664
EI 1537-162X
J9 CLIN NEUROPHARMACOL
JI Clin. Neuropharmacol.
PD SEP-OCT
PY 2013
VL 36
IS 5
BP 151
EP 156
DI 10.1097/WNF.0b013e3182a31ec0
PG 6
WC Clinical Neurology; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 299BD
UT WOS:000330368700003
PM 24045605
ER
PT J
AU Wong, AM
Wang, HS
Schwartz, ES
Toh, CH
Zimmerman, RA
Liu, PL
Wu, YM
Ng, SH
Wang, JJ
AF Wong, A. M.
Wang, H. -S.
Schwartz, E. S.
Toh, C. -H.
Zimmerman, R. A.
Liu, P. -L.
Wu, Y. -M.
Ng, S. -H.
Wang, J. -J.
TI Cerebral Diffusion Tensor MR Tractography in Tuberous Sclerosis Complex:
Correlation with Neurologic Severity and Tract-Based Spatial Statistical
Analysis
SO AMERICAN JOURNAL OF NEURORADIOLOGY
LA English
DT Article
ID WHITE-MATTER; BRAIN; PRINCIPLES; TRACKING; CHILDREN; FEATURES; MODEL
AB BACKGROUND AND PURPOSE: The neurologic significance of residual cerebral white matter tracts, identified on diffusion tensor tractography, has not been well studied in tuberous sclerosis complex. We aimed to correlate the quantity of reconstructed white matter tracts with the degree of neurologic impairment of subjects with the use of DTI and determined differences in white matter integrity between patients with tuberous sclerosis complex and controls with the use of voxelwise analysis.
MATERIALS AND METHODS: In this case-control study, 16 patients with tuberous sclerosis complex and 12 control subjects underwent DTI. Major white matter tracts, comprising bilateral PF and CF, were reconstructed and assessed for quantity, represented by NOP and NOF. A neurologic severity score, based on the presence of developmental disability, seizure, autism, and other neuropsychiatric disorders, was calculated for each subject. We then correlated this score with white matter quantity. Voxelwise tract-based spatial statistics was used to determine differences in FA, axial, and radial diffusivity values between the tuberous sclerosis complex group and the control subjects.
RESULTS: NOP and NOF of CF, bilateral PF, and MWT in the tuberous sclerosis complex group were all significantly lower than those in the control subjects (P < .05). The neurologic severity score was moderately negatively correlated with NOF and NOP regarding CF (r = -.70; r = -.75), bilateral PF (r = -.66; r = -.68), and MWT (r = -.71; r = -.74). Tract-based spatial statistics revealed that patients with tuberous sclerosis complex showed a widespread reduction (P < .05) in FA and axial diffusivity in most cerebral white matter regions.
CONCLUSIONS: Patients with tuberous sclerosis complex with reduced residual white matter were neurologically more severely affected. Tract-based spatial statistics revealed decreased FA and axial diffusivity of the cerebral white matter in the tuberous sclerosis complex group, suggesting reduced axonal integrity.
C1 [Wong, A. M.; Toh, C. -H.; Wu, Y. -M.; Ng, S. -H.; Wang, J. -J.] Chang Gung Mem Hosp, Dept Med Imaging & Intervent, Keelung, Linkou, Taiwan.
[Wong, A. M.; Toh, C. -H.; Wu, Y. -M.; Ng, S. -H.; Wang, J. -J.] Chang Gung Univ, Keelung, Linkou, Taiwan.
[Wang, H. -S.] Chang Gung Childrens Hosp, Dept Pediat, Div Pediat Neurol, Tao Yuan, Taiwan.
[Wang, H. -S.] Chang Gung Univ, Tao Yuan, Taiwan.
[Schwartz, E. S.; Zimmerman, R. A.] Childrens Hosp, Dept Radiol, Philadelphia, PA 19104 USA.
[Liu, P. -L.] Acad Sinica, Inst Informat Sci, Taipei, Taiwan.
RP Wong, AM (reprint author), Chang Gung Mem Hosp, Dept Med Imaging & Intervent, 5 Fu Hsing St, Tao Yuan, Taiwan.
EM alexmcwchop@yahoo.com
RI Ruan, YL/B-9813-2009
FU National Science Council of Taiwan [NSC 94-2314-B-182A-113]
FX This work was supported by the National Science Council of Taiwan (Grant
No. NSC 94-2314-B-182A-113).
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NR 42
TC 2
Z9 2
PU AMER SOC NEURORADIOLOGY
PI DENVILLE
PA PO BOX 3000, DENVILLE, NJ 07834-9349 USA
SN 0195-6108
EI 1936-959X
J9 AM J NEURORADIOL
JI Am. J. Neuroradiol.
PD SEP
PY 2013
VL 34
IS 9
BP 1829
EP 1835
DI 10.3174/ajnr.A3507
PG 7
WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA 291SE
UT WOS:000329848800035
PM 23578671
ER
PT J
AU Kaland, C
Swerts, M
Krahmer, E
AF Kaland, Constantijn
Swerts, Marc
Krahmer, Emiel
TI Accounting for the listener: Comparing the production of contrastive
intonation in typically-developing speakers and speakers with autism
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; FUNDAMENTAL-FREQUENCY; ASPERGER-SYNDROME;
CHILDREN; PROSODY; PROMINENCE; SPEECH; DISAMBIGUATION; INFORMATION;
DISORDERS
AB The present research investigates what drives the prosodic marking of contrastive information. For example, a typically developing speaker of a Germanic language like Dutch generally refers to a pink car as a "PINK car" (accented words in capitals) when a previously mentioned car was red. The main question addressed in this paper is whether contrastive intonation is produced with respect to the speaker's or (also) the listener's perspective on the preceding discourse. Furthermore, this research investigates the production of contrastive intonation by typically developing speakers and speakers with autism. The latter group is investigated because people with autism are argued to have difficulties accounting for another person's mental state and exhibit difficulties in the production and perception of accentuation and pitch range. To this end, utterances with contrastive intonation are elicited from both groups and analyzed in terms of function and form of prosody using production and perception measures. Contrary to expectations, typically developing speakers and speakers with autism produce functionally similar contrastive intonation as both groups account for both their own and their listener's perspective. However, typically developing speakers use a larger pitch range and are perceived as speaking more dynamically than speakers with autism, suggesting differences in their use of prosodic form. (C) 2013 Acoustical Society of America.
C1 [Kaland, Constantijn; Swerts, Marc; Krahmer, Emiel] Tilburg Ctr Cognit & Commun, NL-5000 LE Tilburg, Netherlands.
RP Kaland, C (reprint author), Tilburg Ctr Cognit & Commun, POB 90153, NL-5000 LE Tilburg, Netherlands.
EM c.c.l.kaland@uvt.nl
RI Swerts, Marc/C-8855-2013
FU Netherlands Organisation for Scientific Research (NWO) [277-70-007]
FX The authors thank Sonny de Nijs of Zintri Zorggroep for help with the
recruitment of and the carrying out of the experiment involving
participants with autism and Marieke Hoetjes for help with the
prominence ratings. E.K. thanks The Netherlands Organisation for
Scientific Research (NWO) for Grant No. 277-70-007.
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NR 58
TC 0
Z9 0
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD SEP
PY 2013
VL 134
IS 3
BP 2182
EP 2196
DI 10.1121/1.4816544
PG 15
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 294LG
UT WOS:000330047000045
PM 23967948
ER
PT J
AU Moreau, N
Viallet, F
Champagne-Lavau, M
AF Moreau, Noemie
Viallet, Francois
Champagne-Lavau, Maud
TI Using memories to understand others: The role of episodic memory in
theory of mind impairment in Alzheimer disease
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Theory of mind; Episodic memory; Self-projection; Alzheimer disease;
Mild cognitive impairment
ID MILD COGNITIVE IMPAIRMENT; DEFAULT-MODE NETWORK; VARIANT FRONTOTEMPORAL
DEMENTIA; HIGH-FUNCTIONING AUTISM; AUTOBIOGRAPHICAL MEMORY; SOCIAL
COGNITION; AUTONOETIC CONSCIOUSNESS; ASSOCIATION WORKGROUPS; DIAGNOSTIC
GUIDELINES; NATIONAL INSTITUTE
AB Theory of mind (TOM) refers to the ability to infer one's own and other's mental states. Growing evidence highlighted the presence of impairment on the most complex TOM tasks in Alzheimer disease (AD). However, how TOM deficit is related to other cognitive dysfunctions and more specifically to episodic memory impairment - the prominent feature of this disease - is still under debate. Recent neuroanatomical findings have shown that remembering past events and inferring others' states of mind share the same cerebral network suggesting the two abilities share a common process. This paper proposes to review emergent evidence of TOM impairment in AD patients and to discuss the evidence of a relationship between TOM and episodic memory. We will discuss about AD patients' deficit in TOM being possibly related to their difficulties in recollecting memories of past social interactions. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Moreau, Noemie; Viallet, Francois; Champagne-Lavau, Maud] Aix Marseille Univ, CNRS, LPL, UMR 7309, F-13604 Aix En Provence, France.
[Moreau, Noemie; Viallet, Francois] Ctr Hosp Pays Aix, Dept Neurol, F-13616 Aix En Provence, France.
RP Moreau, N (reprint author), Aix Marseille Univ, CNRS, Lab Parole & Langage, CH Pays Aix,Serv Neurol,UMR 7309, Ave Tamaris, F-13616 Aix En Provence 1, France.
EM nmoreau@ch-aix.fr
FU Agence Nationale de la Recherche [ANR-11-BSH2-006-01 MINDPROGEST]
FX We would like to express our sincere gratitude to Laurent
Martinez-Almoyna and Laurent Renie for their help with the manuscript
and their helpful comments. This work was supported by the Agence
Nationale de la Recherche (ANR-11-BSH2-006-01 MINDPROGEST).
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NR 78
TC 4
Z9 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD SEP
PY 2013
VL 12
IS 4
BP 833
EP 839
DI 10.1016/j.arr.2013.06.005
PG 7
WC Cell Biology; Geriatrics & Gerontology
SC Cell Biology; Geriatrics & Gerontology
GA 278EQ
UT WOS:000328872400001
PM 23838323
ER
PT J
AU Siniscalco, D
Cirillo, A
Bradstreet, JJ
Antonucci, N
AF Siniscalco, Dario
Cirillo, Alessandra
Bradstreet, James Jeffrey
Antonucci, Nicola
TI Epigenetic Findings in Autism: New Perspectives for Therapy
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE autism; gene expression; environmental factors
ID FRAGILE-X-SYNDROME; GENE-ENVIRONMENT INTERACTIONS; SPECTRUM DISORDERS;
OXIDATIVE STRESS; DNA METHYLATION; EXPRESSION; CHILDREN; RECEPTOR;
VASOPRESSIN; MECHANISMS
AB Autism and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders characterized by dysfunctions in social interactions, communications, restricted interests, and repetitive stereotypic behaviors. Despite extensive genetic and biological research, significant controversy surrounds our understanding of the specific mechanisms of their pathogenesis. However, accumulating evidence points to the involvement of epigenetic modifications as foundational in creating ASD pathophysiology. Epigenetic modifications or the alteration of DNA transcription via variations in DNA methylation and histone modifications but without alterations in the DNA sequence, affect gene regulation. These alterations in gene expression, obtained through DNA methylation and/or histone modifications, result from transcriptional regulatory influences of environmental factors, such as nutritional deficiencies, various toxicants, immunological effects, and pharmaceuticals. As such these effects are epigenetic regulators which determine the final biochemistry and physiology of the individual. In contrast to psychopharmacological interventions, bettering our understanding of how these gene-environmental interactions create autistic symptoms should facilitate the development of therapeutic targeting of gene expression for ASD biomedical care.
C1 [Siniscalco, Dario] Univ Naples 2, Dept Expt Med, I-80138 Naples 16, Italy.
[Siniscalco, Dario] Ctr Autism Forza Silenzio, I-81036 Caserta, Italy.
[Siniscalco, Dario] Cancellautismo Nonprofit Assoc Autism Care, I-50132 Florence, Italy.
[Cirillo, Alessandra] Natl Res Council Italy, Inst Prot Biochem, I-80128 Naples, Italy.
[Bradstreet, James Jeffrey] Int Child Dev Resource Ctr, Chateau Elan, GA 30517 USA.
[Antonucci, Nicola] Biomed Ctr Autism Res & Treatment, I-70126 Bari, Italy.
RP Siniscalco, D (reprint author), Univ Naples 2, Dept Expt Med, Via S Maria Costantinopoli, I-80138 Naples 16, Italy.
EM dariosin@uab.edu; cirillo.alessandra@libero.it; drbradstreet@gmail.com;
info@antonucci.eu
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NR 85
TC 7
Z9 7
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2013
VL 10
IS 9
BP 4261
EP 4273
DI 10.3390/ijerph10094261
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 274QD
UT WOS:000328620200029
PM 24030655
ER
PT J
AU Burgess, S
Audet, L
Harjusola-Webb, S
AF Burgess, Sloane
Audet, Lisa
Harjusola-Webb, Sanna
TI Quantitative and qualitative characteristics of the school and home
language environments of preschool-aged children with ASD
SO JOURNAL OF COMMUNICATION DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder; Naturalistic language sampling; Preschool;
Language environment; LENA
ID AUTISM SPECTRUM DISORDERS; YOUNG-CHILDREN; DEVELOPMENTAL-DISABILITIES;
COMMUNICATION; INTERVENTION; 1-YEAR-OLD; IMITATION; PATTERNS; TODDLERS;
INFANTS
AB The purpose of this research was to begin to characterize and compare the school and home language environments of 10 preschool-aged children with Autism Spectrum Disorders (ASD). Naturalistic language samples were collected from each child, utilizing Language ENvironment Analysis (LENA) digital voice recorder technology, at 3-month intervals over the course of one year. LENA software was used to identify 15-min segments of each sample that represented the highest number of adult words used during interactions with each child for all school and home language samples. Selected segments were transcribed and analyzed using Systematic Analysis of Language Transcripts (SALT). LENA data was utilized to evaluate quantitative characteristics of the school and home language environments and SALT data was utilized to evaluate quantitative and qualitative characteristics of language environment. Results revealed many similarities in home and school language environments including the degree of semantic richness, and complexity of adult language, types of utterances, and pragmatic functions of utterances used by adults during interactions with child participants. Study implications and recommendations for future research are discussed.
Learning outcomes: The reader will be able to, (1) describe how two language sampling technologies can be utilized together to collect and analyze language samples, (2) describe characteristics of the school and home language environments of young children with ASD, and (3) identify environmental factors that may lead to more positive expressive language outcomes of young children with ASD. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Burgess, Sloane; Audet, Lisa; Harjusola-Webb, Sanna] Kent State Univ, Kent, OH 44242 USA.
RP Burgess, S (reprint author), Kent State Univ, A104 Mus & Speech Bldg, Kent, OH 44242 USA.
EM sburges8@kent.edu; laudet@kent.edu; shwebb@kent.edu
FU Federal Education Grant; University Research Council at Kent State
University
FX We greatly acknowledge partial support for this project from a Federal
Education Grant awarded to the Hattie Larlham Research Foundation,
Mantua, OH and the University Research Council at Kent State University.
We would also like to acknowledge the graduate and undergraduate
students who so graciously and diligently transcribed audio files.
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NR 48
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0021-9924
EI 1873-7994
J9 J COMMUN DISORD
JI J. Commun. Disord.
PD SEP-DEC
PY 2013
VL 46
IS 5-6
BP 428
EP 439
DI 10.1016/j.jcomdis.2013.09.003
PG 12
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 273HJ
UT WOS:000328525600003
PM 24209428
ER
PT J
AU Van Herwegen, J
Dimitriou, D
Rundblad, G
AF Van Herwegen, Jo
Dimitriou, Dagmara
Rundblad, Gabriella
TI Performance on verbal and low-verbal false belief tasks: Evidence from
children with Williams syndrome
SO JOURNAL OF COMMUNICATION DISORDERS
LA English
DT Article
DE Theory of mind; Williams syndrome; Verbal abilities
ID EXECUTIVE FUNCTION; MIND DEVELOPMENT; LANGUAGE; METAANALYSIS;
INDIVIDUALS; ABILITIES; STABILITY
AB Previous studies that have investigated the relationship between performance on theory of mind (TOM) tasks and verbal abilities in individuals with Williams syndrome (WS) have reported contradictory findings with some showing that language abilities aid performance on ToM tasks while others have found that participants with WS fail these tasks because of their verbal demands. The current study investigated this relationship again comparing performance on a classical change-location task to two newly developed low-verbal tasks, one change-location task and one unexpected content task. Thirty children with WS (aged 5-17;01 years) and 30 typically developing (TD) children (aged between 2;10 years and 9;09 years), who were matched for vocabulary comprehension scores were included in the study. Although performance in the WS group was significantly poorer compared to the TD group on all three tasks, performance was not predicted by their receptive vocabulary or grammatical ability scores. In addition, ToM abilities in both groups depended on the cognitive demands of the task at hand. This finding shows that performance on ToM tasks in WS is not necessarily hindered by their delayed language abilities but rather by the task administered. This could potentially affect the diagnosis of developmental disorders, such as Autism Spectrum Disorders, and comparison of ToM abilities across developmental disorders.
Learning outcomes: Readers of this article should be able to (1) describe the current state of theory of mind research in Williams syndrome, (2) identify which cognitive abilities might explain performance on theory of mind tasks in both typically developing children and in children with Williams syndrome, and (3) interpret the importance of task demands when assessing children's theory of mind abilities. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Van Herwegen, Jo] Univ Kingston, Dept Psychol, Kingston Upon Thames KT1 2EE, Surrey, England.
[Van Herwegen, Jo; Rundblad, Gabriella] Kings Coll London, Dept Educ & Profess Studies, London SE1 9NH, England.
[Dimitriou, Dagmara] Univ London, Inst Educ, Dept Psychol & Human Dev, London WC1H 0AL, England.
RP Van Herwegen, J (reprint author), Univ Kingston, Dept Psychol, Penrhyn Rd, Kingston Upon Thames KT1 2EE, Surrey, England.
EM j.vanherwegen@kingston.ac.uk; d.annaz@ioe.ac.uk;
gabriella.rundblad@kcl.ac.uk
FU ESRC open-competition grant [PTA-030-2006-00235]; University of London
Central Research Fund [REGCRF06-07]; Departmental Scholarship from
King's College London; Williams Syndrome Foundation, UK; Nuffield
Foundation
FX We thank the Williams Syndrome Foundation UK and all the children who
took part in this study. This research was supported by an ESRC
open-competition grant (PTA-030-2006-00235), a grant from the University
of London Central Research Fund (REGCRF06-07), a Departmental
Scholarship from King's College London, a grant from the Williams
Syndrome Foundation, UK and a grant from the Nuffield Foundation. We
also thank reviewers for their comments on an earlier draft of this
manuscript.
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NR 39
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0021-9924
EI 1873-7994
J9 J COMMUN DISORD
JI J. Commun. Disord.
PD SEP-DEC
PY 2013
VL 46
IS 5-6
BP 440
EP 448
DI 10.1016/j.jcomdis.2013.10.002
PG 9
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 273HJ
UT WOS:000328525600004
PM 24239484
ER
PT J
AU Houghton, K
Schuchard, J
Lewis, C
Thompson, CK
AF Houghton, Kat
Schuchard, Julia
Lewis, Charlie
Thompson, Cynthia K.
TI Promoting child-initiated social-communication in children with autism:
Son-Rise Program intervention effects
SO JOURNAL OF COMMUNICATION DISORDERS
LA English
DT Article
DE Autism; Son-Rise Program; Treatment; Social communication; Joint
attention
ID PERVASIVE DEVELOPMENTAL DISORDERS; JOINT ATTENTION; YOUNG-CHILDREN;
PRESCHOOL-CHILDREN; SPECTRUM DISORDERS; SPONTANEOUS SPEECH; LANGUAGE;
MODEL; PLAY; IMITATION
AB This study examined the effects of the Son-Rise Program (SRP), an intensive treatment aimed to improve child-initiated social communication in children with autism. Six children between the ages of 47 and 78 months were provided with 40 h of SRP, with preto post-treatment behavioral changes tested using a novel passive interaction probe task. Results showed an increase in the frequency of spontaneous social orienting and gestural communication for the experimental children, compared to six age- and behaviorallymatched control children with autism. In addition, for the children who received treatment, the duration of social dyadic interactions and total time spent engaged in social interaction increased from pre- to post-treatment. These findings suggest that intensive intervention focused on fostering child-initiated interaction increases social-communicative behaviors in children with autism.
Learning outcomes: Readers will be able to describe the principles underlying the Son-Rise Program, a developmental approach to treatment for autism. Readers will be able to explain the methods of the investigation of a 5-day intensive Son-Rise Program and the results that report change in social communication in children with autism. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
C1 [Houghton, Kat; Lewis, Charlie] Univ Lancaster, Fylde Coll, Dept Psychol, Lancaster LA1 4YF, England.
[Schuchard, Julia; Thompson, Cynthia K.] Northwestern Univ, Dept Commun Sci & Disorders, Evanston, IL 60208 USA.
RP Thompson, CK (reprint author), Northwestern Univ, Dept Commun Sci & Disorders, 2240 Campus Dr, Evanston, IL 60208 USA.
EM kathoughton@taconic.net; schuchard@u.northwestern.edu;
c.lewis@lancaster.ac.uk; ckthom@northwestern.edu
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NR 56
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0021-9924
EI 1873-7994
J9 J COMMUN DISORD
JI J. Commun. Disord.
PD SEP-DEC
PY 2013
VL 46
IS 5-6
BP 495
EP 506
DI 10.1016/j.jcomdis.2013.09.004
PG 12
WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation
GA 273HJ
UT WOS:000328525600009
PM 24209427
ER
PT J
AU Tomalski, P
Moore, DG
Ribeiro, H
Axelsson, EL
Murphy, E
Karmiloff-Smith, A
Johnson, MH
Kushnerenko, E
AF Tomalski, Przemyslaw
Moore, Derek G.
Ribeiro, Helena
Axelsson, Emma L.
Murphy, Elizabeth
Karmiloff-Smith, Annette
Johnson, Mark H.
Kushnerenko, Elena
TI Socioeconomic status and functional brain development - associations in
early infancy
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID SELECTIVE ATTENTION; GAMMA-ACTIVITY; DEPRESSED MOTHERS; YOUNG-CHILDREN;
SLEEP PROBLEMS; EEG; OSCILLATIONS; AUTISM; DISORDER;
ELECTROENCEPHALOGRAM
AB Socioeconomic status (SES) impacts on both structural and functional brain development in childhood, but how early its effects can be demonstrated is unknown. In this study we measured resting baseline EEG activity in the gamma frequency range in awake 6-9-month-olds from areas of East London with high socioeconomic deprivation. Between-subject comparisons of infants from low- and high-income families revealed significantly lower frontal gamma power in infants from low-income homes. Similar power differences were found when comparing infants according to maternal occupation, with lower occupational status groups yielding lower power. Infant sleep, maternal education, length of gestation, and birth weight, as well as smoke exposure and bilingualism, did not explain these differences. Our results show that the effects of socioeconomic disparities on brain activity can already be detected in early infancy, potentially pointing to very early risk for language and attention difficulties. This is the first study to reveal region-selective differences in functional brain development associated with early infancy in low-income families.
C1 [Tomalski, Przemyslaw; Moore, Derek G.; Ribeiro, Helena; Axelsson, Emma L.; Murphy, Elizabeth; Kushnerenko, Elena] Univ E London, Sch Psychol, Inst Res Child Dev, London E15 4LZ, England.
[Ribeiro, Helena; Karmiloff-Smith, Annette; Johnson, Mark H.] Birkbeck Univ London, Dept Psychol Sci, Ctr Brain & Cognit Dev, London, England.
[Tomalski, Przemyslaw] Univ Warsaw, Fac Psychol, PL-00183 Warsaw, Poland.
RP Tomalski, P (reprint author), Univ Warsaw, Fac Psychol, Stawki 5-7, PL-00183 Warsaw, Poland.
EM tomalski@mac.com
RI Kushnerenko, Elena/B-6486-2008
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NR 56
TC 9
Z9 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7687
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD SEP
PY 2013
VL 16
IS 5
SI SI
BP 676
EP 687
DI 10.1111/desc.12079
PG 12
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA 265KG
UT WOS:000327949600005
PM 24033573
ER
PT J
AU Ortega, F
Vidal, F
AF Ortega, Francisco
Vidal, Fernando
TI Brains in Literature/Literature in the Brain
SO POETICS TODAY
LA English
DT Article
ID MEDICAL THRILLERS; SPLIT-BRAIN; NEUROSCIENCE; SCIENCE; FICTION; AUTISM
AB Since the 1990s, several disciplines, from neuroanthropology to neurotheology, have emerged at the interface between neuroscience and the social and human sciences. These "neurodisciplines" share basic assumptions about the brain/mind relationship, a preference for neuroimaging methodology, and the goal of establishing the neurobiological foundations of mind and behavior. A neural turn has also been taken in some quarters within the literary field. The neurosciences have provided writers of literature with resources for depicting characters and psychological processes and states; at the same time, they have inspired new interpretive approaches within literary studies. A twofold motif structures what might be called the neuroliterary field: brains in literature/literature in the brain. There has been a certain convergence between the rise of "neuronovels," on the one hand, and the neurologization of literary analysis, on the other. This article studies that twofold motif. It first sketches how neuronovels fit into the history of neurological fiction and fictional elaborations of brain-related issues. It then examines three aspects of several major neuronovels: narrativity, solipsism and sociality, and memory. The article concludes by underlining the difference between incorporating "brains in literature" and placing "literature in the brain."
C1 [Ortega, Francisco] Univ Estado Rio De Janeiro, Inst Social Med, Rio De Janeiro, Brazil.
[Vidal, Fernando] Autonomous Univ Barcelona, Ctr Hist Sci, ICREA Catalan Inst Res & Adv Studies, E-08193 Barcelona, Spain.
RP Ortega, F (reprint author), Univ Estado Rio De Janeiro, Inst Social Med, Rio De Janeiro, Brazil.
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NR 191
TC 0
Z9 0
PU DUKE UNIV PRESS
PI DURHAM
PA 905 W MAIN ST, STE 18-B, DURHAM, NC 27701 USA
SN 0333-5372
J9 POETICS TODAY
JI Poetics Today
PD FAL
PY 2013
VL 34
IS 3
BP 327
EP 360
DI 10.1215/03335372-2325241
PG 34
WC Literature
SC Literature
GA 270CT
UT WOS:000328297200002
ER
PT J
AU Legido, A
Jethva, R
Goldenthal, MJ
AF Legido, Agustin
Jethva, Reena
Goldenthal, Michael J.
TI Mitochondrial Dysfunction in Autism
SO SEMINARS IN PEDIATRIC NEUROLOGY
LA English
DT Review
ID CARRIER SLC25A12 GENE; TRANSPORT CHAIN COMPLEXES; SPECTRUM DISORDERS;
OXIDATIVE STRESS; RESPIRATORY-CHAIN; IMMUNE ACTIVATION; INBORN-ERRORS;
CHILDREN; DISEASE; ABNORMALITIES
AB Using data of the current prevalence of autism as 200:10,000 and a 1:2000 incidence of definite mitochondrial (mt) disease, if there was no linkage of autism spectrum disorder (ASD) and mt disease, it would be expected that 1 in 110 subjects with mt disease would have ASD and 1 in 2000 individuals with ASD would have mt disease. The co-occurrence of autism and mt disease is much higher than these figures, suggesting a possible pathogenetic relationship. Such hypothesis was initially suggested by the presence of biochemical markers of abnormal mt metabolic function in patients with ASD, including elevation of lactate, pyruvate, or alanine levels in blood, cerebrospinal fluid, or brain; carnitine level in plasma; and level of organic acids in urine, and by demonstrating impaired mt fatty acid beta-oxidation. More recently, mtDNA genetic mutations or deletions or mutations of nuclear genes regulating mt function have been associated with ASD in patients or in neuropathologic studies on the brains of patients with autism. In addition, the presence of dysfunction of the complexes of the mt respiratory chain or electron transport chain, indicating abnormal oxidative phosphorylation, has been reported in patients with ASD and in the autopsy samples of brains. Possible pathogenetic mechanisms linking mt dysfunction and ASD include mt activation of the immune system, abnormal mt Ca2+ handling, and mt-induced oxidative stress. Genetic and epigenetic regulation of brain development may also be disrupted by mt dysfunction, including mt-induced oxidative stress. The role of the purinergic system linking mt dysfunction and ASD is currently under investigation. In summary, there is genetic and biochemical evidence for a mitochondria (mt) role in the pathogenesis of ASD in a subset of children. To determine the prevalence and type of genetic and biochemical mt defects in ASD, there is a need for further research using the latest genetic technology such as next-generation sequencing, microarrays, bioinformatics, and biochemical assays. Because of the availability of potential therapeutic options for nit disease, successful research results could translate into better treatment and outcome for patients with mt-associated ASD. This requires a high index of suspicion of mt disease in children with autism who are diagnosed early. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Legido, Agustin; Jethva, Reena; Goldenthal, Michael J.] St Christophers Hosp Children, Neurol Sect, Philadelphia, PA 19134 USA.
[Legido, Agustin; Jethva, Reena; Goldenthal, Michael J.] Drexel Univ, Coll Med, Dept Pediat, Philadelphia, PA 19104 USA.
[Legido, Agustin; Jethva, Reena; Goldenthal, Michael J.] Drexel Univ, Coll Med, Dept Neurol, Philadelphia, PA 19104 USA.
RP Legido, A (reprint author), St Christophers Hosp Children, Neurol Sect, 3601 A St, Philadelphia, PA 19134 USA.
EM alegido@drexelmed.edu
FU St. Christopher's Foundation (St. Christopher's Hospital for Children);
PHEC (Philadelphia Health Education Corporation); DUCOM (Drexel
University College of Medicine), Philadelphia, PA
FX This work was in part supported by grams from the St. Christopher's
Foundation (St. Christopher's Hospital for Children), PHEC (Philadelphia
Health Education Corporation), and DUCOM (Drexel University College of
Medicine), Philadelphia, PA.
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NR 112
TC 8
Z9 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1071-9091
EI 1558-0776
J9 SEMIN PEDIATR NEUROL
JI Semin. Pediatr. Neurol.
PD SEP
PY 2013
VL 20
IS 3
BP 163
EP 175
DI 10.1016/j.spen.2013.10.008
PG 13
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA 269SK
UT WOS:000328262000002
PM 24331358
ER
PT J
AU Singer-Dudek, J
Oblak, M
AF Singer-Dudek, Jessica
Oblak, Mara
TI PEER PRESENCE AND THE EMERGENCE OF CONDITIONED REINFORCEMENT FROM
OBSERVATION
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE observational learning; conditioned reinforcement; peers
ID CHILDREN; AUTISM; PRESCHOOL
AB We examined the effects of peer presence on the conditioning of new reinforcers via observation. At the outset, strings and toothpicks did not reinforce maintenance or acquisition responses for 3 preschoolers with and without developmental delays. In the first intervention, the stimuli were placed in a cup in front of an empty chair next to the participant, and the participant was denied access to those stimuli. The second intervention was identical to the first, except that a peer was present. Postintervention tests revealed that only the peer intervention was successful in conditioning neutral stimuli as reinforcers for both maintenance and acquisition responses for all 3 participants. The presence of a peer appears to facilitate the conditioning of reinforcers by observation.
C1 [Singer-Dudek, Jessica; Oblak, Mara] Columbia Univ, Teachers Coll, New York, NY 10027 USA.
RP Singer-Dudek, J (reprint author), Columbia Univ, Teachers Coll, Programs Teaching Appl Behav Anal, Box 223,525 West 120th St, New York, NY 10027 USA.
EM dudek@exchange.tc.columbia.edu
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Catania A. C., 2013, LEARNING
Deguchi H, 1984, Behav Anal, V7, P83
Fryling Mitch J, 2011, Anal Verbal Behav, V27, P191
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INGHAM P, 1992, J APPL BEHAV ANAL, V25, P153, DOI 10.1901/jaba.1992.25-153
KAZDIN AE, 1973, J APPL BEHAV ANAL, V6, P71, DOI 10.1901/jaba.1973.6-71
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Ledford JR, 2008, J AUTISM DEV DISORD, V38, P86, DOI 10.1007/s10803-007-0363-7
Miguel Caio F, 2002, Anal Verbal Behav, V18, P3
Premack David, 2003, ORIGINAL INTELLIGENC
Ross DE, 2005, EDUC TRAIN DEV DISAB, V40, P411
Singer-Dudek J., 2008, J EARLY INTENSIVE BE, V25, P57
Singer-Dudek J, 2011, J APPL BEHAV ANAL, V44, P421, DOI 10.1901/jaba.2011.44-421
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WILLIAMS BA, 1994, PSYCHON B REV, V1, P457, DOI 10.3758/BF03210950
NR 21
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 592
EP 602
DI 10.1002/jaba.72
PG 11
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500004
PM 24114222
ER
PT J
AU Peters, LC
Thompson, RH
AF Peters, Lindsay C.
Thompson, Rachel H.
TI SOME INDIRECT EFFECTS OF POSITIVE PRACTICE OVERCORRECTION
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE engagement; positive practice overcorrection; preference; punishment;
stereotypy
ID SELF-STIMULATORY BEHAVIOR; STEREOTYPIC BEHAVIOR;
DEVELOPMENTAL-DISABILITIES; CHILDREN; AUTISM; INTERVENTION; REINFORCER;
PUNISHMENT; DISORDERS; DURATION
AB We evaluated the effects of positive practice overcorrection (PP OC) on levels of motor stereotypy and appropriate engagement in the activity practiced during treatment with 3 young men with autism. We also measured preference for the practiced activities during preference probes to determine if these activities might acquire aversive properties as a result of the frequent pairing with PP OC. Treatment reduced motor stereotypy for all 3 participants, and engagement increased for 2 of the 3 participants. Relative preference for the activities was not disrupted by the implementation of PP OC, although overall contact with the activities decreased for 1 participant. Results from 1 participant suggest that PP OC may be less effective when stereotypy results in access to a more highly preferred activity.
C1 [Peters, Lindsay C.; Thompson, Rachel H.] Western New England Univ, Springfield, MA 01119 USA.
RP Thompson, RH (reprint author), Western New England Univ, Dept Psychol, 1215 Wilbraham Rd, Springfield, MA 01119 USA.
EM rthompson@wne.edu
CR Ahearn WH, 2007, J APPL BEHAV ANAL, V40, P263, DOI 10.1901/jaba.2007.30-06
American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V4th, DOI [10.1176/appi.books.9780890423349, DOI 10.1176/APPI.BOOKS.9780890423349]
AZRIN NH, 1974, J APPL BEHAV ANAL, V7, P577, DOI 10.1901/jaba.1974.7-577
AZRIN NH, 1975, BEHAV THER, V6, P525, DOI 10.1016/S0005-7894(75)80009-8
AZRIN NH, 1975, J BEHAV THER EXP PSY, V6, P145, DOI 10.1016/0005-7916(75)90040-3
BARTON EJ, 1978, BEHAV MODIF, V2, P231, DOI 10.1177/014544557822005
CAREY RG, 1983, J APPL BEHAV ANAL, V16, P101, DOI 10.1901/jaba.1983.16-101
CONLEY OS, 1980, J BEHAV THER EXP PSY, V11, P121, DOI 10.1016/0005-7916(80)90009-9
CROWLEY CP, 1977, J BEHAV THER EXP PSY, V8, P411, DOI 10.1016/0005-7916(77)90012-X
DUNLAP G, 1983, AM J MENT DEF, V88, P194
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Fountain C, 2012, PEDIATRICS, V129, pE1112, DOI 10.1542/peds.2011-1601
Foxx R. M., 1983, EFFECTS PUNISHMENT H, P133
FOXX RM, 1976, BEHAV THER, V7, P390, DOI 10.1016/S0005-7894(76)80069-X
FOXX RM, 1975, BEHAV RES THER, V13, P153, DOI 10.1016/0005-7967(75)90009-1
FOXX RM, 1972, BEHAV RES THER, V10, P15, DOI 10.1016/0005-7967(72)90003-4
FOXX RM, 1977, J APPL BEHAV ANAL, V10, P489, DOI 10.1901/jaba.1977.10-489
FOXX RM, 1973, J APPL BEHAV ANAL, V6, P1, DOI 10.1901/jaba.1973.6-1
Gardenier NC, 2004, RES DEV DISABIL, V25, P99, DOI 10.1016/j.ridd.2003.05.004
HARRIS SL, 1979, J APPL BEHAV ANAL, V12, P185, DOI 10.1901/jaba.1979.12-185
Hobbs S. A., 1976, REHABIL PSYCHOL, V23, P1, DOI [10.1037/h0090908, DOI 10.1037/H0090908]
IWATA BA, 1994, J APPL BEHAV ANAL, V27, P197, DOI 10.1901/jaba.1994.27-197
JONES RSP, 1990, J MENT DEFIC RES, V34, P261
KELLY JA, 1977, J CLIN CHILD PSYCHOL, V6, P38
KOEGEL RL, 1972, J APPL BEHAV ANAL, V5, P381, DOI 10.1901/jaba.1972.5-381
LAGROW SJ, 1984, AM J MENT DEF, V88, P595
Lerman DC, 2002, J APPL BEHAV ANAL, V35, P431, DOI 10.1901/jaba.2002.35-431
Lerman DC, 1996, J APPL BEHAV ANAL, V29, P231, DOI 10.1901/jaba.1996.29-231
LOVAAS OI, 1971, BEHAV RES THER, V9, P39, DOI 10.1016/0005-7967(71)90035-0
MACKENZIEKEATING SE, 1990, BEHAV ANALYST, V13, P39
Miltenberger R G, 1981, Behav Anal, V4, P123
Morrison K, 1997, RES DEV DISABIL, V18, P127, DOI 10.1016/S0891-4222(96)00046-7
PACE GM, 1985, J APPL BEHAV ANAL, V18, P249, DOI 10.1901/jaba.1985.18-249
Reed FDD, 2012, RES AUTISM SPECT DIS, V6, P422, DOI 10.1016/j.rasd.2011.07.003
RISLEY TR, 1968, J APPL BEHAV ANAL, V1, P21, DOI 10.1901/jaba.1968.1-21
ROBERTS P, 1979, AM J MENT DEF, V83, P588
WELLS KC, 1977, J APPL BEHAV ANAL, V10, P679, DOI 10.1901/jaba.1977.10-679
WELLS KC, 1977, J ABNORM CHILD PSYCH, V5, P387, DOI 10.1007/BF00915087
WOLERY M, 1985, J AUTISM DEV DISORD, V15, P149, DOI 10.1007/BF01531601
NR 39
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 613
EP 625
DI 10.1002/jaba.63
PG 13
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500006
PM 24114224
ER
PT J
AU McGhan, AC
Lerman, DC
AF McGhan, Anna C.
Lerman, Dorothea C.
TI AN ASSESSMENT OF ERROR-CORRECTION PROCEDURES FOR LEARNERS WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE assessment; autism; conditional discrimination; error correction
ID INCREASING SPELLING ACHIEVEMENT; DISABILITIES; ACQUISITION; STUDENTS
AB Prior research indicates that the relative effectiveness of different error-correction procedures may be idiosyncratic across learners, suggesting the potential benefit of an individualized assessment prior to teaching. In this study, we evaluated the reliability and utility of a rapid error-correction assessment to identify the least intrusive, most effective procedure for teaching discriminations to 5 learners with autism. The initial assessment included 4 commonly used error-correction procedures. We compared the total number of trials required for the subject to reach the mastery criterion under each procedure. Subjects then received additional instruction with the least intrusive procedure associated with the fewest number of trials and 2 less effective procedures from the assessment. Outcomes of the additional instruction were consistent with those from the initial assessment for 4 of 5 subjects. These findings suggest that an initial assessment may be beneficial for identifying the most appropriate error-correction procedure.
C1 [Lerman, Dorothea C.] Univ Houston Clear Lake, Houston, TX 77058 USA.
RP Lerman, DC (reprint author), Univ Houston Clear Lake, 2700 Bay Area Blvd,MC 245, Houston, TX 77058 USA.
EM lerman@uhcl.edu
CR Ardoin SP, 2009, J APPL BEHAV ANAL, V42, P375, DOI 10.1901/jaba.2009.42-375
BARBETTA PM, 1993, J APPL BEHAV ANAL, V26, P111, DOI 10.1901/jaba.1993.26-111
Coon JT, 2012, J APPL BEHAV ANAL, V45, P657, DOI 10.1901/jaba.2012.45-657
DeLeon IG, 2001, J APPL BEHAV ANAL, V34, P463, DOI 10.1901/jaba.2001.34-463
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
FOXX RM, 1978, BEHAV MODIF, V2, P211, DOI 10.1177/014544557822004
Frost L., 2002, PICTURE EXCHANGE COM, V2nd
Lovaas O. I., 2003, TEACHING INDIVIDUALS
OLLENDICK TH, 1980, J APPL BEHAV ANAL, V13, P645, DOI 10.1901/jaba.1980.13-645
Partington J. W., 2006, ASSESSMENT BASIC LAN
RODGERS TA, 1991, J APPL BEHAV ANAL, V24, P775, DOI 10.1901/jaba.1991.24-775
Smith T, 2006, BEHAV INTERVENT, V21, P245, DOI 10.1002/bin.223
Turan MK, 2012, BEHAV MODIF, V36, P218, DOI 10.1177/0145445511427973
Worsdell AS, 2005, J APPL BEHAV ANAL, V38, P511, DOI 10.1901/jaba.2005.115-04
NR 14
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 626
EP 639
DI 10.1002/jaba.65
PG 14
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500007
PM 24114225
ER
PT J
AU Cividini-Motta, C
Ahearn, WH
AF Cividini-Motta, Catia
Ahearn, William H.
TI EFFECTS OF TWO VARIATIONS OF DIFFERENTIAL REINFORCEMENT ON PROMPT
DEPENDENCY
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; differential reinforcement; prompt dependency; discrimination
ID CHILDREN; AUTISM; ACQUISITION
AB Prompt dependency is an often referenced but little studied problem. The current study evaluated 2 iterations of differential reinforcement (DR) for overcoming prompt dependency and facilitating skill acquisition with 4 individuals who had been diagnosed with an autism spectrum disorder (ASD). Preference and reinforcer assessments were conducted to determine moderately and highly preferred reinforcers for each participant. Three sets of word-picture relations were taught to each of the participants using 1 of 3 DR procedures. Reinforcement for independent responses entailed delivery of the highest preference stimulus across all 3 procedures. Consequences for prompted responses entailed delivery of the highest preference stimulus (no DR), delivery of the moderately preferred stimulus (DR high/moderate), or no delivery of reinforcers (DR high/extinction). Results indicated that the DR high/moderate condition was most effective for 3 of 4 participants, whereas the DR high/extinction condition was most effective for the remaining participant.
C1 [Cividini-Motta, Catia; Ahearn, William H.] Northeastern Univ, New England Ctr Children, Boston, MA USA.
RP Cividini-Motta, C (reprint author), New England Ctr Children, 33 Turnpike Rd, Southborough, MA 01772 USA.
EM ccividini@necc.org
CR Clark KM, 2004, J APPL BEHAV ANAL, V37, P503, DOI 10.1901/jaba.2004.37-503
DEMCHAK M, 1990, AM J MENT RETARD, V94, P603
Fisher WW, 2007, J APPL BEHAV ANAL, V40, P489, DOI 10.1901/jaba.2007.40-489
Karsten AM, 2009, J APPL BEHAV ANAL, V42, P327, DOI 10.1901/jaba.2009.42-327
Libby Myrna E, 2008, Behav Anal Pract, V1, P37
OLENICK DL, 1980, J APPL BEHAV ANAL, V13, P77, DOI 10.1901/jaba.1980.13-77
OPPENHEIMER M, 1993, RES DEV DISABIL, V14, P425, DOI 10.1016/0891-4222(93)90036-J
Sindelar P. T., 1985, ED TREATMENT CHILDRE, V8, P67
Smaby K, 2007, BEHAV INTERVENT, V22, P311, DOI 10.1002/bin.242
TERRACE HS, 1963, J EXP ANAL BEHAV, V6, P1, DOI 10.1901/jeab.1963.6-1
TOUCHETTE PE, 1984, J APPL BEHAV ANAL, V17, P175, DOI 10.1901/jaba.1984.17-175
NR 11
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 640
EP 650
DI 10.1002/jaba.67
PG 11
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500008
PM 24114226
ER
PT J
AU Lepper, TL
Petursdottir, AI
Esch, BE
AF Lepper, Tracy L.
Petursdottir, Anna Ingeborg
Esch, Barbara E.
TI EFFECTS OF OPERANT DISCRIMINATION TRAINING ON THE VOCALIZATIONS OF
NONVERBAL CHILDREN WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; discrimination training; speech; stimulus-stimulus pairing;
vocalizations
ID PREFERENCE
AB We evaluated the effects of operant discrimination training (ODT) on the vocalizations of 3 boys with autism. We compared ODT to a stimulus-stimulus pairing (SSP) condition and a control condition in an adapted alternating-treatments design. ODT increased the target vocalizations of all participants compared to the control condition, and its effects were similar to SSP. All participants preferred ODT to SSP.
C1 [Lepper, Tracy L.; Petursdottir, Anna Ingeborg] Texas Christian Univ, Ft Worth, TX 76129 USA.
[Esch, Barbara E.] Esch Behav Consultants Inc, Kalamazoo, MI USA.
RP Petursdottir, AI (reprint author), Texas Christian Univ, Dept Psychol, TCU Box 298920, Ft Worth, TX 76129 USA.
EM a.petursdottir@tcu.edu
CR Esch B. E., 2008, VERBAL BEHAV MILESTO, P62
Esch Barbara E, 2005, Anal Verbal Behav, V21, P43
Esch BE, 2009, J APPL BEHAV ANAL, V42, P225, DOI 10.1901/jaba.2009.42-225
Hanley GP, 1997, J APPL BEHAV ANAL, V30, P459, DOI 10.1901/jaba.1997.30-459
Holth P., 2009, EUROPEAN J BEHAV ANA, V10, P143
Luczynski KC, 2009, J APPL BEHAV ANAL, V42, P511, DOI 10.1901/jaba.2009.42-511
Sindelar P. T., 1985, ED TREATMENT CHILDRE, V8, P67
Sundberg M. L., 1998, TEACHING LANGUAGE CH
Sundberg M L, 1996, Anal Verbal Behav, V13, P21
NR 9
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 656
EP 661
DI 10.1002/jaba.55
PG 6
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500010
PM 24114228
ER
PT J
AU Dupere, S
MacDonald, RPF
Ahearn, WH
AF Dupere, Sally
MacDonald, Rebecca P. F.
Ahearn, William H.
TI USING VIDEO MODELING WITH SUBSTITUTABLE LOOPS TO TEACH VARIED PLAY TO
CHILDREN WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; play; video modeling; generalization
ID PRETEND PLAY
AB Children with autism often engage in repetitive play with little variation in the actions performed or items used. This study examined the use of video modeling with scripted substitutable loops on children's pretend play with trained and untrained characters. Three young children with autism were shown a video model of scripted toy play that included a substitutable loop that allowed various characters to perform the same actions and vocalizations. Three characters were modeled with the substitutable loop during training sessions, and 3 additional characters were present in the video but never modeled. Following video modeling, all the participants incorporated untrained characters into their play, but the extent to which they did so varied.
EM bmacdonald@necc.org
CR D'Ateno P, 2003, J POSIT BEHAV INTERV, V5, P5, DOI 10.1177/10983007030050010801
Hine JF, 2006, TOP EARLY CHILD SPEC, V26, P83, DOI 10.1177/02711214060260020301
Lifter K., 2000, PLAY DIAGNOSIS ASSES, P228
MacDonald R, 2005, BEHAV INTERVENT, V20, P225, DOI 10.1002/bin.197
MacDonald R, 2009, J APPL BEHAV ANAL, V42, P43, DOI 10.1901/jaba.2009.42-43
Roberts S., 2007, AUTISM RELATED DEV D, V23, P1
STOKES TF, 1977, J APPL BEHAV ANAL, V10, P349, DOI 10.1901/jaba.1977.10-349
NR 7
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 662
EP 668
DI 10.1002/jaba.68
PG 7
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500011
PM 24114229
ER
PT J
AU Miguel, CF
Kobari-Wright, VV
AF Miguel, Caio F.
Kobari-Wright, Vissy V.
TI THE EFFECTS OF TACT TRAINING ON THE EMERGENCE OF CATEGORIZATION AND
LISTENER BEHAVIOR IN CHILDREN WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; categorization; naming; verbal behavior
AB We evaluated the effects of tact training on the emergence of categorization and listener behavior using a nonconcurrent multiple baseline design across 2 children with autism. Participants learned to tact the category name of 9 pictures that belonged to 3 different categories. We assessed whether participants accurately matched pictures by category and selected the correct comparisons when hearing their category names. After training, participants categorized and emitted listener behavior. One participant did not categorize until asked to tact the samples. These results suggest that tact training may be an efficient way to produce listener and categorization in children diagnosed with autism.
C1 [Miguel, Caio F.; Kobari-Wright, Vissy V.] Calif State Univ Sacramento, Sacramento, CA 95819 USA.
RP Miguel, CF (reprint author), Calif State Univ Sacramento, Dept Psychol, 6000 J St, Sacramento, CA 95819 USA.
EM miguelc@csus.edu
CR Horne PJ, 1996, J EXP ANAL BEHAV, V65, P185, DOI 10.1901/jeab.1996.65-185
Lowe CF, 2002, J EXP ANAL BEHAV, V78, P527
Miguel C. F., 2009, DERIVED RELATIONAL R, P129
Miguel CF, 2008, J EXP ANAL BEHAV, V89, P383, DOI 10.1901/jeab.2008-89-383
NR 4
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 669
EP 673
DI 10.1002/jaba.62
PG 5
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500012
PM 24114230
ER
PT J
AU Kryzak, LA
Bauer, S
Jones, EA
Sturmey, P
AF Kryzak, Lauren A.
Bauer, Sara
Jones, Emily A.
Sturmey, Peter
TI INCREASING RESPONDING TO OTHERS' JOINT ATTENTION DIRECTIVES USING
CIRCUMSCRIBED INTERESTS
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; joint attention; circumscribed interests
ID CHILDREN; AUTISM; BEHAVIORS; INTERVENTION
AB Children with autism show significant deficits in joint attention (JA), which occurs when 2 people engage in verbalizations, gestures, or eye contact with each other and a common object. Children with autism also exhibit intense interests in specific topics (i.e., circumscribed interests; CI). This study investigated the effectiveness of teaching responding to JA directives (RJA) to 3 children with autism while engaged in CI activities. RJA increased during intervention and generalized from CI to preferred activities.
C1 Queens Coll, Queens, NY 11367 USA.
CUNY, Grad Ctr, New York, NY USA.
RP Jones, EA (reprint author), Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Queens, NY 11367 USA.
EM Emily.jones@qc.cuny.edu
CR BAKEMAN R, 1984, CHILD DEV, V55, P1278, DOI 10.2307/1129997
Baker M. J., 2000, J POSIT BEHAV INTERV, V2, P66, DOI 10.1177/109830070000200201
Boyd BA, 2007, J AUTISM DEV DISORD, V37, P1550, DOI 10.1007/s10803-006-0286-8
CHARLOP MH, 1990, J APPL BEHAV ANAL, V23, P163, DOI 10.1901/jaba.1990.23-163
Jones EA, 2006, BEHAV MODIF, V30, P782, DOI 10.1177/0145445506289392
MUNDY P, 1995, DEV PSYCHOPATHOL, V7, P63
Vismara LA, 2007, J POSIT BEHAV INTERV, V9, P214, DOI 10.1177/10983007070090040401
Whalen C, 2003, J CHILD PSYCHOL PSYC, V44, P456, DOI 10.1111/1469-7610.00135
White PJ, 2011, RES AUTISM SPECT DIS, V5, P1283, DOI 10.1016/j.rasd.2011.02.003
NR 9
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 674
EP 679
DI 10.1002/jaba.73
PG 6
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500013
PM 24114231
ER
PT J
AU Watts, AC
Wilder, DA
Gregory, MK
Leon, Y
Ditzian, K
AF Watts, Amanda C.
Wilder, David A.
Gregory, Meagan K.
Leon, Yanerys
Ditzian, Kyle
TI THE EFFECT OF RULES ON DIFFERENTIAL REINFORCEMENT OF OTHER BEHAVIOR
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE autism; automatic reinforcement; differential reinforcement of other
behavior; rules; rule-governed behavior
ID PREFERENCES
AB Previous research on the treatment of problem behavior has shown differential reinforcement of other behavior (DRO) to be an effective behavior-reduction procedure. However, the extent to which presession descriptions of the DRO contingency enhance intervention effects has not been examined. In the current study, we compared a condition in which a presession rule that described the DRO contingency was given to a condition in which no rule was given for 4 participants. The target behavior was toy play, which served as an analogue to problem behavior maintained by automatic reinforcement. Results showed that DRO was more efficient for 1 participant and more effective for 2 participants when a rule was given.
C1 [Watts, Amanda C.; Wilder, David A.; Gregory, Meagan K.; Leon, Yanerys; Ditzian, Kyle] Florida Inst Technol, Scott Ctr Autism Treatment, Melbourne, FL 32901 USA.
RP Wilder, DA (reprint author), Florida Inst Technol, Sch Psychol, 150 W Univ Blvd, Melbourne, FL 32901 USA.
EM dawilder@fit.edu
CR DeLeon IG, 1996, J APPL BEHAV ANAL, V29, P519, DOI 10.1901/jaba.1996.29-519
DeLeon IG, 1999, J APPL BEHAV ANAL, V32, P111, DOI 10.1901/jaba.1999.32-111
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Matson JL, 2011, RES DEV DISABIL, V32, P681, DOI 10.1016/j.ridd.2010.11.014
MAZALESKI JL, 1993, J APPL BEHAV ANAL, V26, P143, DOI 10.1901/jaba.1993.26-143
Ringdahl JE, 2002, BEHAV INTERVENT, V17, P43, DOI 10.1002/bin.105
Sundberg M. L., 2008, VB MAPP VERBAL BEHAV
NR 7
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 680
EP 684
DI 10.1002/jaba.53
PG 5
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500014
PM 24114232
ER
PT J
AU Kenzer, AL
Bishop, MR
Wilke, AE
Tarbox, JR
AF Kenzer, Amy L.
Bishop, Michele R.
Wilke, Arthur E.
Tarbox, Jonathan R.
TI INCLUDING UNFAMILIAR STIMULI IN PREFERENCE ASSESSMENTS FOR YOUNG
CHILDREN WITH AUTISM
SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS
LA English
DT Article
DE stimulus preference; reinforcer assessment; autism spectrum disorder
ID DISABILITIES
AB This study examined the inclusion of familiar and unfamiliar stimuli in a paired-stimulus preference assessment and subsequent progressive-ratio reinforcer assessment for 3 children with an autism spectrum disorder (ASD). Results showed that highly preferred unfamiliar stimuli functioned as reinforcers. These findings suggest that the inclusion of unfamiliar stimuli in preference assessments may facilitate the identification of additional reinforcers for children with an ASD.
C1 [Kenzer, Amy L.; Bishop, Michele R.; Wilke, Arthur E.; Tarbox, Jonathan R.] Ctr Autism & Related Disorders Inc, Phoenix, AZ 85008 USA.
RP Kenzer, AL (reprint author), Ctr Autism & Related Disorders Inc, 1620 N 48th St, Phoenix, AZ 85008 USA.
EM a.kenzer@centerforautism.com
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
Fisher WW, 1996, AM J MENT RETARD, V101, P15
Kenzer AL, 2011, RES AUTISM SPECT DIS, V5, P819, DOI 10.1016/j.rasd.2010.09.011
Lim L, 2001, EDUC TRAIN MENT RET, V36, P188
Roane HS, 2008, J APPL BEHAV ANAL, V41, P155, DOI 10.1901/jaba.2008.41-155
NR 6
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8855
EI 1938-3703
J9 J APPL BEHAV ANAL
JI J. Appl. Behav. Anal.
PD FAL
PY 2013
VL 46
IS 3
BP 689
EP 694
DI 10.1002/jaba.56
PG 6
WC Psychology, Clinical
SC Psychology
GA 267YO
UT WOS:000328134500016
PM 24114234
ER
PT J
AU Kohls, G
Perino, MT
Taylor, JM
Madva, EN
Cayless, SJ
Troiani, V
Price, E
Faja, S
Herrington, JD
Schultz, RT
AF Kohls, Gregor
Perino, Michael T.
Taylor, James M.
Madva, Elizabeth N.
Cayless, Sarah J.
Troiani, Vanessa
Price, Elinora
Faja, Susan
Herrington, John D.
Schultz, Robert T.
TI The nucleus accumbens is involved in both the pursuit of social reward
and the avoidance of social punishment
SO NEUROPSYCHOLOGIA
LA English
DT Article
DE Ventral striatum; Nucleus accumbens; Social reward; Social punishment;
Motivation; Avoidance
ID HUMAN BRAIN; DECISION-MAKING; ANTICIPATION; DOPAMINE; MOTIVATION;
AUTISM; RESPONSES; MONETARY; BEHAVIOR; SIGNALS
AB Human social motivation is characterized by the pursuit of social reward and the avoidance of social punishment. The ventral striatum/nucleus accumbens (VS/Nacc), in particular, has been implicated in the reward component of social motivation, i.e., the 'wanting' of social incentives like approval. However, it is unclear to what extent the VS/Nacc is involved in avoiding social punishment like disapproval, an intrinsically pleasant outcome. Thus, we conducted an event-related functional magnetic resonance imaging (fMRI) study using a social incentive delay task with dynamic video stimuli instead of static pictures as social incentives in order to examine participants' motivation for social reward gain and social punishment avoidance. As predicted, the anticipation of avoidable social punishment (i.e., disapproval) recruited the VS/Nacc in a manner that was similar to VS/Nacc activation observed during the anticipation of social reward gain (i.e., approval). Stronger VS/Nacc activity was accompanied by faster reaction times of the participants to obtain those desired outcomes. This data support the assumption that dynamic social incentives elicit robust VS/Nacc activity, which likely reflects motivation to obtain social reward and to avoid social punishment. Clinical implications regarding the involvement of the VS/Nacc in social motivation dysfunction in autism and social phobia are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Kohls, Gregor; Madva, Elizabeth N.; Cayless, Sarah J.; Troiani, Vanessa; Price, Elinora; Herrington, John D.; Schultz, Robert T.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA USA.
[Kohls, Gregor] Rhein Westfal TH Aachen, Child Neuropsychol Sect, Dept Child & Adolescent Psychiat & Psychotherapy, Aachen, Germany.
[Perino, Michael T.] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA.
[Taylor, James M.] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA.
[Troiani, Vanessa] Univ Penn, Dept Neurosci, Philadelphia, PA 19104 USA.
[Faja, Susan] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Schultz, Robert T.] Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA.
[Schultz, Robert T.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
RP Kohls, G (reprint author), RWTH Aachen Univ Hosp, Child Neuropsychol Sect, Dept Child & Adolescent Psychiat, Neuenhofer Weg 21, D-52074 Aachen, Germany.
EM kohlsgregor@gmail.com
FU Robert Wood Johnson Foundation [66727]; NINDS Postdoctoral Award
[T32NS007413]
FX This work was supported by a grant from the Robert Wood Johnson
Foundation (#66727) to RTS and a NINDS Postdoctoral Award (T32NS007413)
to SF.
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NR 81
TC 8
Z9 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3932
EI 1873-3514
J9 NEUROPSYCHOLOGIA
JI Neuropsychologia
PD SEP
PY 2013
VL 51
IS 11
BP 2062
EP 2069
DI 10.1016/j.neuropsychologia.2013.07.020
PG 8
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 266EF
UT WOS:000328005500002
PM 23911778
ER
PT J
AU Carter, EW
Lane, KL
Cooney, M
Weir, K
Moss, CK
Machalicek, W
AF Carter, Erik W.
Lane, Kathleen Lynne
Cooney, Molly
Weir, Katherine
Moss, Colleen K.
Machalicek, Wendy
TI Self-Determination Among Transition-Age Youth With Autism or
Intellectual Disability: Parent Perspectives
SO RESEARCH AND PRACTICE FOR PERSONS WITH SEVERE DISABILITIES
LA English
DT Article
DE transition; parents; autism; self-determination; severe disabilities
ID STUDENTS; PREDICTORS; EMPLOYMENT; TEACHERS; IMPACT; VIEWS
AB This study examined 68 parents' views of the self-determination skills and capacities of their young adult children with autism spectrum disorders and intellectual disability (ages 19-21 years). Results indicated parents placed a high value on the importance of all seven component skills (i.e., choice-making skills, decision-making skills, goal-setting skills, problem-solving skills, self-advocacy and leadership skills, self-awareness and self-knowledge, and self-management and self-regulation skills) associated with enhanced self-determination. Yet, parents indicated their young adult children did not often perform these skills well. Effect sizes suggested high-magnitude differences between parents' ratings of the importance and their child's performance for each self-determination skill evaluated. Furthermore, regression analyses indicated parents' perceptions of the severity of their child's disability accounted for a significant portion of the variance in the overall ratings of their child's performance of these seven skills (26%) and overall self-determination capacity (27%). Parents who described their children's disabilities as being less severe rated their children as having higher performance levels on both measures of self-determination. Educational implications are presented along with recommendations for future research.
C1 [Carter, Erik W.] Vanderbilt Univ, Nashville, TN 37203 USA.
[Lane, Kathleen Lynne] Univ Kansas, Lawrence, KS 66045 USA.
[Cooney, Molly; Weir, Katherine; Moss, Colleen K.] Univ Wisconsin Madison, Madison, WI USA.
[Machalicek, Wendy] Univ Oregon, Eugene, OR 97403 USA.
RP Carter, EW (reprint author), Vanderbilt Univ, Dept Special Educ, Peabody Coll, 230 Appleton Pl,Box 328, Nashville, TN 37203 USA.
EM erik.carter@vanderbilt.edu
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NR 31
TC 1
Z9 1
PU TASH
PI WASHINGTON
PA 1025 VERMONT AVE, NW 7TH FLR, WASHINGTON, DC 20005 USA
SN 0274-9483
J9 RES PRACT PERS SEV D
JI Res. Pract. Pers. Sev. Disabil.
PD FAL
PY 2013
VL 38
IS 3
BP 129
EP 138
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 266DR
UT WOS:000328004100001
ER
PT J
AU Fisch, GS
AF Fisch, Gene S.
TI "Nosology and Epidemiology in Autism: Classification Counts" (vol 160,
pg 91, 2012)
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Correction
C1 [Fisch, Gene S.] NYU, Coll Dent, Dept Epidemiol & Hlth Promot, New York, NY 10003 USA.
[Fisch, Gene S.] NYU, Coll Nursing, Dept Epidemiol & Hlth Promot, New York, NY 10003 USA.
RP Fisch, GS (reprint author), NYU, Coll Dent, Dept Epidemiol & Hlth Promot, 250 Pk Ave South,6th Fl, New York, NY 10003 USA.
EM gene.fisch@nyu.edu
CR Fisch GS, 2012, AM J MED GENET C, V160C, P91, DOI 10.1002/ajmg.c.31325
NR 1
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD SEP
PY 2013
VL 161
IS 9
BP 2399
EP 2399
DI 10.1002/ajmg.a.36064
PG 1
WC Genetics & Heredity
SC Genetics & Heredity
GA 263HQ
UT WOS:000327798800042
ER
PT J
AU Gu, F
Chauhan, V
Kaur, K
Brown, WT
LaFauci, G
Wegiel, J
Chauhan, A
AF Gu, F.
Chauhan, V.
Kaur, K.
Brown, W. T.
LaFauci, G.
Wegiel, J.
Chauhan, A.
TI Alterations in mitochondrial DNA copy number and the activities of
electron transport chain complexes and pyruvate dehydrogenase in the
frontal cortex from subjects with autism
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
DE autism; electron transport chain; mitochondrial DNA; mitochondrial
dysfunction; oxidative stress; pyruvate dehydrogenase
ID OXIDATIVE STRESS; SPECTRUM DISORDERS; RESPIRATORY-CHAIN;
ALZHEIMERS-DISEASE; PSYCHIATRIC-DISORDERS; PARKINSONS-DISEASE; RADICAL
GENERATION; LIPID-PEROXIDATION; BIPOLAR DISORDER; DOWN-SYNDROME
AB Autism is a neurodevelopmental disorder associated with social deficits and behavioral abnormalities. Recent evidence suggests that mitochondrial dysfunction and oxidative stress may contribute to the etiology of autism. This is the first study to compare the activities of mitochondrial electron transport chain (ETC) complexes (I-V) and pyruvate dehydrogenase (PDH), as well as mitochondrial DNA (mtDNA) copy number in the frontal cortex tissues from autistic and age-matched control subjects. The activities of complexes I, V and PDH were most affected in autism (n = 14) being significantly reduced by 31%, 36% and 35%, respectively. When 99% confidence interval (CI) of control group was taken as a reference range, impaired activities of complexes I, III and V were observed in 43%, 29% and 43% of autistic subjects, respectively. Reduced activities of all five ETC complexes were observed in 14% of autistic cases, and the activities of multiple complexes were decreased in 29% of autistic subjects. These results suggest that defects in complexes I and III (sites of mitochondrial free radical generation) and complex V (adenosine triphosphate synthase) are more prevalent in autism. PDH activity was also reduced in 57% of autistic subjects. The ratios of mtDNA of three mitochondrial genes ND1, ND4 and Cyt B (that encode for subunits of complexes I and III) to nuclear DNA were significantly increased in autism, suggesting a higher mtDNA copy number in autism. Compared with the 95% CI of the control group, 44% of autistic children showed higher copy numbers of all three mitochondrial genes examined. Furthermore, ND4 and Cyt B deletions were observed in 44% and 33% of autistic children, respectively. This study indicates that autism is associated with mitochondrial dysfunction in the brain.
C1 [Gu, F.; Chauhan, V.; Kaur, K.; Brown, W. T.; LaFauci, G.; Wegiel, J.; Chauhan, A.] NYS Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA.
RP Chauhan, A (reprint author), NYS Inst Basic Res Dev Disabil, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM abha.chauhan@opwdd.ny.gov
FU Department of Defense Autism [AS073224P2]; Autism Research Institute;
NYS Office for People
FX Human brain tissues were obtained from the National Institute of Child
Health and Human Development Brain and Tissue Bank for Developmental
Disorders at the University of Maryland, Baltimore, MD. This work was
supported by funds from the Department of Defense Autism Spectrum
Disorders Research Program AS073224P2, the Autism Research Institute and
the NYS Office for People with Developmental Disabilities.
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NR 76
TC 9
Z9 11
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD SEP
PY 2013
VL 3
AR e299
DI 10.1038/tp.2013.68
PG 8
WC Psychiatry
SC Psychiatry
GA 258PX
UT WOS:000327472300002
PM 24002085
ER
PT J
AU Martin, PM
Yang, X
Robin, N
Lam, E
Rabinowitz, JS
Erdman, CA
Quinn, J
Weiss, LA
Hamilton, SP
Kwok, PY
Moon, RT
Cheyette, BNR
AF Martin, P-M
Yang, X.
Robin, N.
Lam, E.
Rabinowitz, J. S.
Erdman, C. A.
Quinn, J.
Weiss, L. A.
Hamilton, S. P.
Kwok, P-Y
Moon, R. T.
Cheyette, B. N. R.
TI A rare WNT1 missense variant overrepresented in ASD leads to increased
Wnt signal pathway activation
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
DE association study; functional analysis; mutation burden; psychiatric
disorders; rare mutations
ID AUTISM SPECTRUM DISORDERS; MAJOR PSYCHIATRIC-DISORDERS; DE-NOVO
MUTATIONS; BETA-CATENIN; SOCIAL-INTERACTION; NEURAL DEVELOPMENT;
HIGH-THROUGHPUT; GENE; SCHIZOPHRENIA; ASSOCIATION
AB Wnt signaling, which encompasses multiple biochemical pathways that regulate neural development downstream of extracellular Wnt glycoprotein ligands, has been suggested to contribute to major psychiatric disorders including autism spectrum disorders (ASD). We used next-generation sequencing and Sequenom genotyping technologies to resequence 10 Wnt signaling pathway genes in 198 ASD patients and 240 matched controls. Results for single-nucleotide polymorphisms (SNPs) of interest were confirmed in a second set of 91 ASD and 144 control samples. We found a significantly increased burden of extremely rare missense variants predicted to be deleterious by PolyPhen-2, distributed across seven genes in the ASD sample (3.5% in ASD vs 0.8% in controls; Fisher's exact test, odds ratio (OR) = 4.37, P = 0.04). We also found a missense variant in WNT1 (S88R) that was overrepresented in the ASD sample (8 A/T in 267 ASD (minor allele frequency (MAF) = 1.69%) vs 1 A/T in 377 controls (MAF = 0.13%), OR = 13.0, Fisher's exact test, P = 0.0048; OR = 8.2 and P = 0.053 after correction for population stratification). Functional analysis revealed that WNT1-S88R is more active than wild-type WNT1 in assays for the Wnt/beta-catenin signaling pathway. Our findings of a higher burden in ASD of rare missense variants distributed across 7 of 10 Wnt signaling pathway genes tested, and of a functional variant at the WNT1 locus associated with ASD, support that dysfunction of this pathway contributes to ASD susceptibility. Given recent findings of common molecular mechanisms in ASD, schizophrenia and affective disorders, these loci merit scrutiny in other psychiatric conditions as well.
C1 [Martin, P-M; Yang, X.; Erdman, C. A.; Quinn, J.; Weiss, L. A.; Hamilton, S. P.; Cheyette, B. N. R.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94158 USA.
[Robin, N.; Rabinowitz, J. S.; Moon, R. T.] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA.
[Robin, N.; Rabinowitz, J. S.; Moon, R. T.] Univ Washington, Howard Hughes Med Inst, Sch Med, Seattle, WA 98195 USA.
[Lam, E.; Erdman, C. A.; Quinn, J.; Weiss, L. A.; Hamilton, S. P.; Kwok, P-Y] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94158 USA.
RP Cheyette, BNR (reprint author), Univ Calif San Francisco, Dept Psychiat, Rock Hall Room 284D,1550 4th St, San Francisco, CA 94158 USA.
EM bc@ucsf.edu
RI Moon, Randall/B-1743-2014; Cheyette, Benjamin/K-5535-2014
OI Moon, Randall/0000-0002-9352-1408; Cheyette,
Benjamin/0000-0001-9934-7941
FU Kristine Yaffe; Roy and Marie Scola Endowed Chair in Psychiatry at UCSF;
NIH [T32 MH089920]; Department of Psychiatry; Center for Neurobiology
and Psychiatry; International Mental Health Research Organization
FX P-MM has received support from a Pilot Project award sponsored by
Kristine Yaffe, the Roy and Marie Scola Endowed Chair in Psychiatry at
UCSF; XYY was funded by NIH T32 MH089920; this research has also been
supported by grants to BNRC and SPH together and to BNRC alone from the
UCSF Research Allocation Program (RAP) including the Program for
Breakthrough Biomedical Research (PBBR), by the Department of
Psychiatry, and by the Center for Neurobiology and Psychiatry. LAW has
support from the International Mental Health Research Organization. We
acknowledge SFARI for ASD genomic DNA samples and for phenotypic data
made available on SFARI Base. We also thank all the families who donated
samples and the principal investigators involved in their collection (A
Beaudet, R Bernier, J Constantino, E Cook, E Fombonne, D Geschwind, D
Grice, A Klin, D Ledbetter, C Lord, C Martin, D Martin, R Maxim, J
Miles, O Ousley, B Peterson, J Piggot, C Saulnier, M State, W Stone, J
Sutcliffe, C Walsh and E Wijsman). Approved researchers can obtain the
SSC population data set by applying at https://base.sfari.org.
Collection of the control data set was supported by grants from the NIMH
and the National Alliance for Research on Schizophrenia and Depression.
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TC 2
Z9 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD SEP
PY 2013
VL 3
AR e301
DI 10.1038/tp.2013.75
PG 6
WC Psychiatry
SC Psychiatry
GA 258PX
UT WOS:000327472300004
PM 24002087
ER
PT J
AU Wilkinson, KM
McIlvane, WJ
AF Wilkinson, Krista M.
McIlvane, William J.
TI Perceptual Factors Influence Visual Search for Meaningful Symbols in
Individuals With Intellectual Disabilities and Down Syndrome or Autism
Spectrum Disorders
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE augmentative communication; severe disabilities; visual search; display
design
ID COLOR CUES; PRESCHOOLERS SPEED; MENTAL-RETARDATION; LINE-DRAWINGS;
CHILDREN; COMMUNICATION; ATTENTION; LANGUAGE; RECOGNITION; BEHAVIORS
AB Augmentative and alternative communication (AAC) systems often supplement oral communication for individuals with intellectual and communication disabilities. Research with preschoolers without disabilities has demonstrated that two visual-perceptual factors influence speed and/or accuracy of finding a target: the internal color and spatial organization of symbols. Twelve participants with Down syndrome and 12 with autism spectrum disorders (ASDs) completed two search tasks. In one, the symbols were clustered by internal color; in the other, the identical symbols had no arrangement cue. Visual search was superior in participants with ASDs compared to those with Down syndrome. In both groups, responses were significantly faster when the symbols were clustered by internal color. Construction of aided AAC displays may benefit from attention to their physical and perceptual features.
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[Wilkinson, Krista M.; McIlvane, William J.] Univ Massachusetts, Sch Med, Shriver Ctr, Amherst, MA 01003 USA.
RP Wilkinson, KM (reprint author), Penn State Univ, 308 Ford Hall, University Pk, PA 16802 USA.
EM kmw22@psu.edu
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NR 43
TC 1
Z9 1
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2013
VL 118
IS 5
BP 353
EP 364
DI 10.1352/1944-7558-118.5.353
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 258FC
UT WOS:000327443600003
PM 24245729
ER
PT J
AU Smith, AL
Romski, M
Sevcik, RA
AF Smith, Ashlyn L.
Romski, MaryAnn
Sevcik, Rose A.
TI Examining the Role of Communication on Sibling Relationship Quality and
Interaction for Sibling Pairs With and Without a Developmental
Disability
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE sibling relationships; intellectual and/or developmental disability;
communication
ID MENTAL-RETARDATION; DOWN-SYNDROME; YOUNGER SIBLINGS; OLDER SIBLINGS;
CHILDREN; PERCEPTIONS; AUTISM; HOME; PERSPECTIVES; STRATEGIES
AB This study examined communication interaction patterns when one sibling had a developmental disability as well as the role of communication skills in sibling relationship quality. Thirty sibling dyads were categorized into one of three communication status groups: emerging, context-dependent, and independent communicators. Independent communicators and their siblings did not differ in terms of syntactic complexity but typically developing siblings dominated the interaction and exhibited greater lexical diversity regardless of communication status. Communication status did not impact the warmth/closeness, rivalry, or conflict in the sibling relationship, but siblings of independent communicators engaged in the greatest amount of helping and managing behaviors. These results represent a first step in understanding the role of communication skills in the sibling relationship for families of children with disabilities.
C1 [Smith, Ashlyn L.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
[Romski, MaryAnn; Sevcik, Rose A.] Georgia State Univ, Atlanta, GA 30303 USA.
RP Smith, AL (reprint author), Univ Wisconsin, Waisman Ctr, 1500 Highland Ave, Madison, WI 53705 USA.
EM alsmith35@waisman.wisc.edu
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NR 41
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD SEP
PY 2013
VL 118
IS 5
BP 394
EP 409
DI 10.1352/1944-7558-118.5.394
PG 16
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 258FC
UT WOS:000327443600006
PM 24245732
ER
PT J
AU Christian, RB
Farley, JF
Sheitman, B
McKee, JR
Wei, D
Diamond, J
Chrisman, A
Barnhill, LJ
Wegner, L
Palmes, G
Trygstad, T
Pfeiffenberger, T
Wegner, SE
Best, R
Sikich, L
AF Christian, Robert B.
Farley, Joel F.
Sheitman, Brian
McKee, Jerry R.
Wei, David
Diamond, John
Chrisman, Alan
Barnhill, Larry Jarrett, Jr.
Wegner, Lynn
Palmes, Guy
Trygstad, Troy
Pfeiffenberger, Trista
Wegner, Steven E.
Best, Randell
Sikich, Linmarie
TI A plus KIDS, a Web-Based Antipsychotic Registry for North Carolina
Youths: An Alternative to Prior Authorization
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID 2ND-GENERATION ANTIPSYCHOTICS; NATIONAL TRENDS; DRUG USE; CHILDREN;
MEDICATIONS; ADOLESCENTS; USERS
AB Objective: The rise in use of antipsychotics among U. S. children is well documented. Compliance rates with current safety-monitoring guidelines are low. In response, the North Carolina Division of Medical Assistance established the Antipsychotics-Keeping It Documented for Safety (A+KIDS) registry. The initial objectives of the project were to successfully establish a Web-based safety registry and to obtain and evaluate clinical information derived from the registry. Methods: In April 2011, A+KIDS began asking prescribers of antipsychotics for children age 12 and under to respond to a set of questions regarding dose, indication, and usage history. Antipsychotic registrations were examined by linking North Carolina Medicaid prescription claims to registry entries. Prescribers were classified into different types, and the number of patients and registrations per prescriber were examined. Results: In the initial six months, 730 prescribers registered 5,532 patients, 19% below age seven. By month 6 of the registry, 72% of all fills were registered with the program. Top diagnosis groups for registry patients were unspecified mood disorders, autism spectrum disorders, and disruptive behavior disorders. Top target symptoms were aggression (48%), irritability (19%), and impulsivity (11%). Psychosis accounted for 5% of the target symptoms. Twenty-eight percent of children were receiving no form of psychotherapy. Twenty-five percent of all A+KIDS prescribers were responsible for 81% of the registrations. Conclusions: The A+KIDS registry initiative has been successful, as measured by rapid uptake, and is providing clinical information not available from claims data alone. Future efforts will allow for detailed examinations of antipsychotic utilization and further safety improvement.
C1 [Christian, Robert B.] Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
[Christian, Robert B.] Univ North Carolina UNC Chapel Hill, Sch Med, Dept Psychiat, Chapel Hill, NC USA.
[Farley, Joel F.; Sheitman, Brian; Barnhill, Larry Jarrett, Jr.; Sikich, Linmarie] UNC Eshelman, Sch Pharm, Chapel Hill, NC USA.
[McKee, Jerry R.; Diamond, John; Trygstad, Troy; Pfeiffenberger, Trista] East Carolina Univ Brody, Sch Med, Dept Psychiat, Greenville, NC USA.
[Chrisman, Alan] Duke Univ, Dept Psychiat, Sch Med, Durham, NC 27706 USA.
[Wegner, Lynn] UNC, Dept Pediat, Chapel Hill, NC USA.
[Palmes, Guy] Wake Forest Univ, Dept Psychiat, Winston Salem, NC 27109 USA.
[Wegner, Steven E.] AccessCare North Carolina, Morrisville, NC USA.
[Best, Randell] North Carolina Dept Med Assistance, Raleigh, NC USA.
RP Christian, RB (reprint author), Carolina Inst Dev Disabil, CB 7255, Chapel Hill, NC 27599 USA.
EM rob.christian@cidd.unc.edu
FU AccessCare North Carolina; Bristol-Myers Squibb; Curemark; Merck;
Forest; Otsuka Research Institute; SynapDx; Seaside Pharmaceuticals
FX This work was funded through a contract with AccessCare North
Carolina.Dr. Farley has been a consultant to Novartis and
Daiichi-Sankyo. Dr. Sikich has received research funding in the past
three years from or participates in clinical trials sponsored by
Bristol-Myers Squibb, Curemark, Merck, Forest, Otsuka Research
Institute, SynapDx, and Seaside Pharmaceuticals, and she has received
software for a computer intervention in schizophrenia from Posit
Science. The other authors report no competing interests.
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NR 19
TC 0
Z9 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD SEP
PY 2013
VL 64
IS 9
BP 893
EP 900
DI 10.1176/appi.ps.002762012
PG 8
WC Health Policy & Services; Public, Environmental & Occupational Health;
Psychiatry
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Psychiatry
GA 255ZC
UT WOS:000327277600013
PM 23728296
ER
PT J
AU Veening, JG
Olivier, B
AF Veening, Jan G.
Olivier, Berend
TI Intranasal administration of oxytocin: Behavioral and clinical effects,
a review
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Intranasal administration; Oxytocin; Behavioral effects; Clinical
effects
ID CENTRAL-NERVOUS-SYSTEM; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS;
CEREBROSPINAL-FLUID ABSORPTION; BLOOD-BRAIN-BARRIER; MAIN
OLFACTORY-BULB; OBSESSIVE-COMPULSIVE DISORDER; MOUSE HEPATITIS-VIRUS;
MIRROR-NEURON SYSTEM; SENSORY CIRCUMVENTRICULAR ORGANS; PERIHYPOPHYSEAL
CAVERNOUS SINUS
AB The intranasal (IN-) administration of substances is attracting attention from scientists as well as pharmaceutical companies. The effects are surprisingly fast and specific. The present review explores our current knowledge about the routes of access to the cranial cavity. 'Direct-access-pathways' from the nasal cavity have been described but many additional experiments are needed to answer a variety of open questions regarding anatomy and physiology.
Among the IN-applied substances oxytocin (OT) has an extensive history. Originally applied in women for its physiological effects related to lactation and parturition, over the last decade most studies focused on their behavioral 'prosocial' effects: from social relations and 'trust' to treatment of 'autism'.
Only very recently in a microdialysis study in rats and mice, the 'direct-nose-brain-pathways' of IN-OT have been investigated directly, implying that we are strongly dependent on results obtained from other IN-applied substances. Especially the possibility that IN-OT activates the 'intrinsic' OT-system in the hypothalamus as well needs further clarification.
We conclude that IN-OT administration may be a promising approach to influence human communication but that the existing lack of information about the neural and physiological mechanisms involved is a serious problem for the proper understanding and interpretation of the observed effects. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Veening, Jan G.; Olivier, Berend] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacol, NL-3508 TB Utrecht, Netherlands.
[Veening, Jan G.] Radboud Univ Med Sci, Dept Anat 109, NL-6500 HB Nijmegen, Netherlands.
RP Veening, JG (reprint author), Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacol, POB 80082, NL-3508 TB Utrecht, Netherlands.
EM j.veening@anat.umcn.nl
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NR 484
TC 24
Z9 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD SEP
PY 2013
VL 37
IS 8
BP 1445
EP 1465
DI 10.1016/j.neubiorev.2013.04.012
PG 21
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 251BK
UT WOS:000326902600010
PM 23648680
ER
PT J
AU Blanchard, DC
Summers, CH
Blanchard, RJ
AF Blanchard, D. Caroline
Summers, Cliff H.
Blanchard, Robert J.
TI The role of behavior in translational models for psychopathology:
Functionality and dysfunctional behaviors
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Translational research; Animal models; Biomarkers; Anxiety; Depression;
Autism; Adaptive behavior; Functionality of behavior; Psychopathology
ID PLUS TF/J MICE; AUTISM SPECTRUM DISORDERS; VISIBLE BURROW SYSTEM;
HEPARAN-SULFATE; ANIMAL-MODELS; DEFENSIVE BEHAVIORS; FACIAL EXPRESSIONS;
THREAT SCENARIOS; NONHUMAN MAMMALS; INBRED STRAINS
AB The history of science has frequently included a problem-based impetus toward research that can be translated expeditiously into solutions. A current problem is that psychopathologies, typically chronic, contribute hugely to the economic and social burden of medical care, especially in the United States. For behavioral neuroscientists a psychopathology-aimed translational research emphasis particularly involves animal models to facilitate the experimental and invasive work necessary to an understanding of the biology of normal and aberrant behavior. When the etiology of a particular psychopathology is unknown, and there are no specific biomarkers, behavioral parallels between the focal disorder and its putative models become crucial elements in assessing model validity. Evaluation of these parallels is frequently neglected, reflecting in part the lack of a systematic conceptualization of the organization of behavior and how this may be conserved across species. Recent work specifically attempting to bridge this gap suggests that analysis of behaviors that are functional adaptive in crucial situations such as danger or social contexts can facilitate an understanding of the parallels between behaviors of human and nonhuman species, including the dysfunctional behaviors of psycho pathologies. As research with animal models comes to provide a more systematic analysis of particular behaviors and their adaptive functions, cross-talk between model and focal psychopathology may be advantageous to understanding both. Published by Elsevier Ltd.
C1 [Blanchard, D. Caroline; Blanchard, Robert J.] Pacific Biosci Res Ctr, Honolulu, HI 96822 USA.
[Summers, Cliff H.] Univ S Dakota, Dept Biol, Vermillion, SD 57069 USA.
[Summers, Cliff H.] Univ S Dakota, Sanford Sch Med, BBS, Neurosci Grp, Vermillion, SD 57069 USA.
[Blanchard, Robert J.] Univ Hawaii, Dept Psychol, Honolulu, HI 96825 USA.
RP Blanchard, DC (reprint author), Pacific Biosci Res Ctr, 1993 East West Rd, Honolulu, HI 96822 USA.
EM blanchar@hawaii.edu
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NR 85
TC 2
Z9 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD SEP
PY 2013
VL 37
IS 8
BP 1567
EP 1577
DI 10.1016/j.neubiorev.2013.06.008
PG 11
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 251BK
UT WOS:000326902600019
PM 23791787
ER
PT J
AU Aoki, Y
Inokuchi, R
Suwa, H
Aoki, A
AF Aoki, Yuta
Inokuchi, Ryota
Suwa, Hiroshi
Aoki, Ai
TI Age-related change of neurochemical abnormality in attention-deficit
hyperactivity disorder: A meta-analysis
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE ADHD; Methylphenidate; Magnetic resonance spectroscopy; MRS; Attention
deficit disorder; ADD
ID MAGNETIC-RESONANCE-SPECTROSCOPY; OBSESSIVE-COMPULSIVE DISORDER;
DEFICIT/HYPERACTIVITY DISORDER; N-ACETYLASPARTATE; BIPOLAR DISORDER;
BRAIN; ADHD; CHILDREN; GLUTAMATE; AUTISM
AB Prevalence and symptoms of attention-deficit hyperactivity disorder (ADHD) change with advancing age. However, neurochemical background of such age-related change is yet to be elucidated. We therefore conducted a meta-analysis of 16 proton magnetic resonance spectroscopy studies comprising 270 individuals with ADHD and 235 controls. Standardized mean differences were calculated and used as an effect size. Sensitivity analyses and meta-regression to explore the effect of age on neurochemical abnormality were performed. A random effects model identified a significantly higher-than-normal N-acetylaspartate (NAA) in the medial prefrontal cortex (mPFC), but no significant differences of other metabolites in that area. No significant difference in metabolite levels was demonstrated in any other region. Sensitivity analysis of children with ADHD revealed significantly higher-than-normal NAA, whereas no significant difference was found in adults with ADHD. Meta-regression revealed significant correlation between advanced age and normal levels of NAA in the mPFC, suggesting that age-dependent abnormality of NAA level in the mPFC is a potential neural basis of age-related change of symptoms of ADHD. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Aoki, Yuta; Suwa, Hiroshi; Aoki, Ai] Ebara Hosp, Tokyo Metropolitan Hlth & Med Treatment Corp, Dept Psychiat, Ota Ku, Tokyo 1450065, Japan.
[Aoki, Yuta; Inokuchi, Ryota] Tokyo Univ Hosp, Dept Emergency & Crit Care Med, Tokyo 1138655, Japan.
[Inokuchi, Ryota] Univ Tokyo, Grad Sch Med, Dept Emergency & Crit Care Med, Tokyo 1138655, Japan.
RP Aoki, Y (reprint author), Ebara Hosp, Tokyo Metropolitan Hlth & Med Treatment Corp, Dept Psychiat, Ota Ku, Tokyo 1450065, Japan.
EM yuaoki-tky@umin.ac.jp
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NR 52
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD SEP
PY 2013
VL 37
IS 8
BP 1692
EP 1701
DI 10.1016/j.neubiorev.2013.04.019
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 251BK
UT WOS:000326902600028
PM 23735885
ER
PT J
AU Catani, M
Dell'Acqua, F
Thiebaut de Schotten, M
AF Catani, Marco
Dell'Acqua, Flavio
Thiebaut de Schotten, Michel
TI A revised limbic system model for memory, emotion and behaviour
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Limbic system; Tractography; White matter connections; Brain networks;
Emotion; Memory; Amnesia; Dementia; Antisocial behaviour; Schizophrenia;
Depression; Bipolar disorder; Obsessive-compulsive disorder; Autism
spectrum disorder
ID VOXEL-BASED MORPHOMETRY; TEMPORAL-LOBE EPILEPSY; DIFFUSION TENSOR
TRACTOGRAPHY; OBSESSIVE-COMPULSIVE DISORDER; CEREBRAL WHITE-MATTER;
COMORBIDITY SURVEY REPLICATION; SUBGENUAL PREFRONTAL CORTEX; MAJOR
DEPRESSIVE DISORDER; ANTERIOR CINGULATE CORTEX; DEEP BRAIN-STIMULATION
AB Emotion, memories and behaviour emerge from the coordinated activities of regions connected by the limbic system. Here, we propose an update of the limbic model based on the seminal work of Papez, Yakovlev and MacLean. In the revised model we identify three distinct but partially overlapping networks: (i) the Hippocampal-diencephalic and parahippocampal-retrosplenial network dedicated to memory and spatial orientation; (ii) The temporo-amygdala-orbitofrontal network for the integration of visceral sensation and emotion with semantic memory and behaviour; (iii) the default-mode network involved in autobiographical memories and introspective self-directed thinking. The three networks share cortical nodes that are emerging as principal hubs in connectomic analysis. This revised network model of the limbic system reconciles recent functional imaging findings with anatomical accounts of clinical disorders commonly associated with limbic pathology. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Catani, Marco; Dell'Acqua, Flavio; Thiebaut de Schotten, Michel] Kings Coll London, Dept Forens & Neurodev Sci, Natbrainlab, Inst Psychiat, London WC2R 2LS, England.
[Dell'Acqua, Flavio] Kings Coll London, Inst Psychiat, Dept Neuroimaging Sci, London WC2R 2LS, England.
[Dell'Acqua, Flavio] Kings Coll London, NIHR Biomed Res Ctr Mental Hlth, South London & Maudsley NHS Fdn Trust, London WC2R 2LS, England.
[Dell'Acqua, Flavio] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
[Thiebaut de Schotten, Michel] Grp Hosp Pitie Salpetriere, CNRS UMR 7225, UMR S 975, Ctr Rech,Inst Cerveau & Moelle Epiniere, F-75013 Paris, France.
RP Catani, M (reprint author), Inst Psychiat, Dept Forens & Neurodev Sci, Natbrainlab, 16 De Crespigny Pk, London SE5 8AF, England.
EM m.catani@iop.kcl.ac.uk; michel.thiebaut@gmail.com
FU Natbrainlab; Emilio Verche; Guy's and St. Thomas' Charity; French Agence
Nationale de la Recherche [ANR-09-RPDOC-004-01, ANR-09-EMER-006]
FX We thank the Natbrainlab (http://www.natbrainlab.com), Emilio Verche,
Guy's and St. Thomas' Charity and the French Agence Nationale de la
Recherche (project CAFORPFC, no. ANR-09-RPDOC-004-01 and project HM-TC,
no. ANR-09-EMER-006).
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NR 166
TC 21
Z9 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD SEP
PY 2013
VL 37
IS 8
BP 1724
EP 1737
DI 10.1016/j.neubiorev.2013.07.001
PG 14
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 251BK
UT WOS:000326902600031
PM 23850593
ER
PT J
AU Romani, PW
Suess, AN
Whittington, H
Kopelman, C
Ringdahl, JE
Vinquist, KM
Dutt, A
AF Romani, Patrick W.
Suess, Alyssa N.
Whittington, Haley
Kopelman, Clark
Ringdahl, Joel E.
Vinquist, Kelly M.
Dutt, Anuradha
TI PROMPT DENSITY, RATE OF REINFORCEMENT, AND THE PERSISTENCE OF MANDING
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE behavioral persistence; developmental disabilities; prompts
ID LONG-TERM TREATMENT; BEHAVIORAL MOMENTUM; MULTIPLE SCHEDULES; CHILDREN;
DISABILITIES; RESISTANCE; EXTINCTION; PREFERENCE; AUTISM; DELAY
AB Previous research has documented the effects of prompting mands at a relatively high rate (i.e., rich schedule) or low rate (i.e., lean schedule). These previous studies have not addressed the possibility of prompt dependency as an explanation for these results. Furthermore, the implications of a collateral effect of prompt density, increased response-reinforcer pairings, have not been investigated. The current studies sought to address these two questions. During Experiment 1, the effect of prompt density (i.e., high and low prompt rate) on manding was evaluated. The inclusion of a control condition (i.e., prompts in the absence of the relevant establishing operation and reinforcement) isolated the effect of prompts on manding. During Experiment 2, a collateral effect of relatively high prompt density, increased reinforcer rate, on response persistence was evaluated. Results showed that manding rates varied with prompt rate and did not appear to be prompt dependent. Finally, mands persisted longer following a relatively rich prompt schedule than a relatively lean prompt schedule.
C1 [Romani, Patrick W.; Suess, Alyssa N.; Whittington, Haley; Kopelman, Clark] Univ Iowa, Ctr Disabil & Dev, Iowa City, IA 52242 USA.
[Ringdahl, Joel E.] So Illinois Univ, Inst Rehabil, Behav Anal & Therapy Program, Carbondale, IL 62901 USA.
[Vinquist, Kelly M.] Trinity Serv Inc, Trin Family Resources, New Lenox, IL USA.
[Dutt, Anuradha] Natl Inst Educ, Singapore, Singapore.
RP Romani, PW (reprint author), Ctr Disabil & Dev, 100 Hawkins Dr,Rm 251, Iowa City, IA 52242 USA.
EM patrick-romani@uiowa.edu
CR ALBERTO P. A., 2009, APPL BEHAV ANAL TEAC
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NR 25
TC 0
Z9 0
PU PSYCHOLOGICAL RECORD
PI CARBONDALE
PA SOUTHERN ILLINOIS UNIV, REHABILITATION INSTITUTE, CARBONDALE, IL
62901-4609 USA
SN 0033-2933
EI 2163-3452
J9 PSYCHOL REC
JI Psychol. Rec.
PD FAL
PY 2013
VL 63
IS 4
BP 821
EP 833
PG 13
WC Psychology, Multidisciplinary
SC Psychology
GA 252ID
UT WOS:000326997500008
ER
PT J
AU Porokhovnik, LN
Pasekov, VP
Yegolina, NA
Tzvetkova, TG
Kosyakova, NV
Gorbachevskaya, NL
Sukhotina, NK
Kozlovskaya, GV
Sorokin, AB
Korovina, NY
Lyapunova, NA
AF Porokhovnik, L. N.
Pasekov, V. P.
Yegolina, N. A.
Tzvetkova, T. G.
Kosyakova, N. V.
Gorbachevskaya, N. L.
Sukhotina, N. K.
Kozlovskaya, G. V.
Sorokin, A. B.
Korovina, N. Yu.
Lyapunova, N. A.
TI Oxidative stress, rRNA genes, and antioxidant enzymes in pathogenesis of
schizophrenia and autism: Modeling and clinical advices
SO ZHURNAL OBSHCHEI BIOLOGII
LA Russian
DT Article
ID NUCLEOLUS ORGANIZER REGIONS; RADICAL SCAVENGING ENZYMES;
RHEUMATOID-ARTHRITIS; LIPID-PEROXIDATION; SUPEROXIDE-DISMUTASE; SPECTRUM
DISORDERS; NEGATIVE ASSOCIATION; HUMAN-CHROMOSOMES; BIPOLAR DISORDER;
DEFENSE SYSTEM
AB Ribosomal genes (RG), or genes for rRNA, are represented by multiple tandem repeats in eukaryotic genomes, and just a part of them is transcriptionally active. The quantity of active copies is a stable genome feature which determines the cell's capability for rapid synthesis of proteins, necessary to cope with stress conditions. Low number of active RG copies leads to reduced stress resistance and elevated risk of multifactorial disorders (MFD). Oxidative stress (OS) in the brain cells is believed to be involved in the pathogenesis of infantile autism (IA) and schizophrenia, i.e., MFDs with a manifested genetic predisposition. With autism, OS markers are found almost in every research, whilst with schizophrenia, the OS data are contradictory. Earlier, in a sample of patients with schizophrenia, we have found significantly higher quantity of active RG copies than at the average in healthy population. Here we have estimated the number of active RG copies in a sample of patients with IA (n = 51) and revealed significantly lower mean value than in healthy population. A novel mathematical model of the dynamic pattern of OS has been proposed. The model is realized as an ordinary differential equation system, supposing induction of antioxidant protection enzymes being mediated by reactive oxygen species (ROS), with the subsequent decrease of ROS content in a cell. The rate of synthesis of antioxidant protection enzymes is limited by the ribosome synthesis rate which depends on the number of active RG copies. Analysis of the model showed that the system always approaches a single stable equilibrium point along a damped oscillation trajectory, which in some degree resembles the dynamics of 'predator-prey' interaction in Lotka-Volterra model. The stationary ROS level inversely depends on the number of active RG copies. Our study explains the inconsistency of clinical data of OS in schizophrenia and suggests a novel criterion for discriminative cytogenetic diagnostics of schizophrenia and IA, as well as allows to assume that antioxidant therapy should be effective only for children with low number of active RG copies.
C1 [Porokhovnik, L. N.; Yegolina, N. A.; Tzvetkova, T. G.; Kosyakova, N. V.; Lyapunova, N. A.] Russian Acad Med Sci, Med Genet Res Ctr, Moscow 115478, Russia.
[Pasekov, V. P.] RAS, Dorodnicyn Comp Ctr, Moscow 119333, Russia.
[Gorbachevskaya, N. L.; Kozlovskaya, G. V.; Sorokin, A. B.] RAMS, Mental Hlth Res Ctr, Moscow 115522, Russia.
[Sukhotina, N. K.; Korovina, N. Yu.] Moscow Res Inst Psychiat, Moscow 107076, Russia.
[Gorbachevskaya, N. L.; Sorokin, A. B.] Moscow Municipal Univ Psychol & Educ, Moscow 127051, Russia.
RP Porokhovnik, LN (reprint author), Russian Acad Med Sci, Med Genet Res Ctr, Moskvorechye 1, Moscow 115478, Russia.
EM lp_sof@mail.ru; pass40@mail.ru; gorbachevskaya@yandex.ru
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NR 78
TC 0
Z9 0
PU MEZHDUNARODNAYA KNIGA
PI MOSCOW
PA 39 DIMITROVA UL., MOSCOW, 113095, RUSSIA
SN 0044-4596
J9 ZH OBSHCH BIOL
JI Zhurnal Obshchei Biol.
PD SEP-OCT
PY 2013
VL 74
IS 5
BP 340
EP 353
PG 14
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA 245TE
UT WOS:000326485900002
PM 25438566
ER
PT J
AU Wudarczyk, OA
Earp, BD
Guastella, A
Savulescu, J
AF Wudarczyk, Olga A.
Earp, Brian D.
Guastella, Adam
Savulescu, Julian
TI Could intranasal oxytocin be used to enhance relationships? Research
imperatives, clinical policy, and ethical considerations
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Review
DE couples therapy; love drugs; marriage; neuroenhancement; oxytocin
ID AUTISM SPECTRUM DISORDERS; MARITAL DISTRESS; SOCIAL-BEHAVIOR; COUPLE
THERAPY; ROMANTIC LOVE; ADULT ATTACHMENT; MATE CHOICE; HUMAN BRAIN;
HUMANS; VASOPRESSIN
AB Purpose of reviewWell-functioning romantic relationships are important for long-term health and well being, but they are often difficult to sustain. This difficulty arises (in part) because of an underlying tension between our psychobiological natures, culture/environment, and modern love and relationship goals. One possible solution to this predicament is to intervene at the level of psychobiology, enhancing partners' interpersonal connection through neurochemical modulation. This article focuses on a single, promising biobehavioral sub-system for such intervention: the attachment system, based largely upon the expression of the neuropeptide oxytocin. Could the exogenous administration of oxytocin - under the right conditions - be used to facilitate relational or marital well being?Recent findingsIf so, it would require considerable forethought. Recent research complicates the popular image of oxytocin as a universal social enhancer or love hormone' and shows that it may exert a variety of different effects, at different dosages, on different people, under different circumstances. Accordingly, we discuss what is known about oxytocin, including its good' and bad' effects on human behavior and on higher-order functional processes.SummaryBuilding upon animal-model, human preclinical, and clinical findings, we outline a proposal for the use of oxytocin in the therapeutic neuroenhancement of contemporary romantic relationships. Highlighting key targets for future research along the way, we then conclude by discussing some of the clinical and ethical considerations that would pertain to the implementation of this knowledge in applied settings.Video abstracthttp://links.lww.com/YCO/A23
C1 [Wudarczyk, Olga A.; Earp, Brian D.; Savulescu, Julian] Univ Oxford, Oxford Ctr Neuroeth, Oxford, England.
[Wudarczyk, Olga A.] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany.
[Earp, Brian D.; Savulescu, Julian] Univ Oxford, Uehiro Ctr Pract Eth, Oxford, England.
[Guastella, Adam] Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
RP Wudarczyk, OA (reprint author), Oxford Ctr Neuroeth, Suite 8,Littlegate House,St Ebbes St, Oxford OX1 1PT, England.
EM owudarczyk@gmail.com; brian.earp@gmail.com
FU Wellcome Trust [08604/Z/08/Z]; Oxford Martin School
FX Thanks are due to Laura Colberg, Christina Regenbogen, and an
unidentified reviewer for helpful feedback on an earlier draft. This
work was supported by a Wellcome Trust Grant, #08604/Z/08/Z, and by the
Oxford Martin School.
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NR 88
TC 4
Z9 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD SEP
PY 2013
VL 26
IS 5
BP 474
EP 484
DI 10.1097/YCO.0b013e3283642e10
PG 11
WC Psychiatry
SC Psychiatry
GA 249YB
UT WOS:000326815900009
PM 23880593
ER
PT J
AU Mathersul, D
McDonald, S
Rushby, JA
AF Mathersul, Danielle
McDonald, Skye
Rushby, Jacqueline A.
TI Autonomic arousal explains social cognitive abilities in
high-functioning adults with autism spectrum disorder
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Article
DE Autism; Asperger's; Skin conductance; Arousal; Empathy; Emotion
ID PERVASIVE DEVELOPMENTAL DISORDERS; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; SKIN-CONDUCTANCE RESPONSES; AGE 15 YEARS; ASPERGER-SYNDROME;
EMPATHY QUOTIENT; STIMULUS SIGNIFICANCE; PSYCHIATRIC-PATIENTS;
DEVELOPING-CHILDREN; ORIENTING RESPONSE
AB Empirical research into behavioural profiles and autonomic responsivity in individuals with autism spectrum disorders (ASDs) is highly variable and inconsistent. Two preliminary studies of children with ASDs suggest that there may be subgroups of ASDs depending on their resting arousal levels, and that these subgroups show different profiles of autonomic responsivity. The aim of the present study was to determine whether (i) adults with high-functioning ASDs may be separated into subgroups according to variation in resting arousal; and (ii) these ASD arousal subgroups differ in their behavioural profiles for basic emotion recognition, judgements of trustworthiness, and cognitive and affective empathy. Thirty high-functioning adults with ASDs and 34 non-clinical controls participated. Resting arousal was determined as the average skin conductance (SCL) across a 2 min resting period. There was a subgroup of ASD adults with significantly lower resting SCL. These individuals demonstrated poorer emotion recognition, tended to judge faces more negatively, and had atypical relationships between SCL and affective empathy. In contrast, low cognitive empathy was a feature of all ASD adults. These findings have important implications for clinical interventions and future studies investigating autonomic functioning in ASDs. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Mathersul, Danielle; McDonald, Skye; Rushby, Jacqueline A.] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
RP Mathersul, D (reprint author), Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
EM d.mathersul@unsw.edu.au
RI McDonald, Skye/G-4118-2014
OI McDonald, Skye/0000-0003-0723-6094
FU Australian Postgraduate Award (APA); Australian National Health and
Medical Research Council (NHMRC) [APP1013796]; Australian NHMRC
FX DM is supported by an Australian Postgraduate Award (APA). JAR is
supported by an Australian National Health and Medical Research Council
(NHMRC) Postdoctoral Fellowship (Clinical Training; APP1013796). This
research was funded by the Australian NHMRC. We would like to thank the
individuals who gave their time to participate in this study and the
clinicians who assisted with participant recruitment.
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NR 87
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8760
EI 1872-7697
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD SEP
PY 2013
VL 89
IS 3
SI SI
BP 475
EP 482
DI 10.1016/j.ijpsycho.2013.04.014
PG 8
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 245AV
UT WOS:000326432200024
PM 23628291
ER
PT J
AU Gulec-Aslan, Y
AF Gulec-Aslan, Yesim
TI A Training Programme for a Teacher Working with a Student with ASD: An
Action Research
SO KURAM VE UYGULAMADA EGITIM BILIMLERI
LA English
DT Article
DE Action Research; Applied Behavior Analysis; Autism Spectrum Disorders
(ASD); Discrete Trial Teaching; Educator Training; Inductive Analysis;
Qualitative Research; Special Education
ID SPECIAL-EDUCATION TEACHERS; AUTISM-SPECTRUM-DISORDERS; YOUNG-CHILDREN;
PARENT; INTERVENTIONS; IMPLEMENTATION; RETENTION; OUTCOMES; SKILLS
AB The qualifications of the educators who teach children with Autism Spectrum Disorders (ASD) may affect the outputs of the education. Qualified educators play an important role in skill development. Therefore, educators need to have special qualifications. Within this scope, it is important to organize well-designed training programs for the educators which aims enabling them to gain the skills and the knowledge specific to autism. In this action research, the problems of the educators working with children with ASD are described, with an aim to solve these problems and to provide training for meeting such needs and to analyze the results. Research data were collected through a variety of methods including observations, meetings, interviews, researcher reflections and artifacts. The data were analyzed via inductive analysis. The findings are interpreted into seven themes as follows: Teaching problems, behavioral problems, dealing with teaching and behavioral problems, educational needs, educational practices aimed at solving the existing problems and meeting the needs and changes in the process of implementation, changes in the performances of the participants, opinions of the participants on educational practices. Findings reveal that the participants did benefit from the educational practices offered. All findings are discussed in parallel with the relevant literature.
C1 [Gulec-Aslan, Yesim] Sakarya Univ, TR-54300 Hendek, Sakarya, Turkey.
RP Gulec-Aslan, Y (reprint author), Sakarya Univ, Dept Special Educ, TR-54300 Hendek, Sakarya, Turkey.
EM yesima@sakarya.edu.tr
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Vuran S., 2012, KURAM UYGULAMADA EGI, V12, P2091
NR 78
TC 0
Z9 0
PU EDAM
PI ISTANBUL
PA KISIKLI MH ALEMDAG CD YAN YOL SK, SBK IS MERKEZI NO 5, KAT 1 USKUDAR,
ISTANBUL, 81190, TURKEY
SN 1303-0485
J9 KURAM UYGUL EGIT BIL
JI Kuram Uygulamada Egit. Bilim.
PD FAL
PY 2013
VL 13
IS 4
BP 2229
EP 2246
PG 18
WC Education & Educational Research
SC Education & Educational Research
GA 247UQ
UT WOS:000326648300015
ER
PT J
AU Parnell, SE
Holloway, HT
O'Leary-Moore, SK
Dehart, DB
Paniaqua, B
Oguz, I
Budin, F
Styner, MA
Johnson, GA
Sulik, KK
AF Parnell, Scott E.
Holloway, Hunter T.
O'Leary-Moore, Shonagh K.
Dehart, Deborah B.
Paniaqua, Beatriz
Oguz, Ipek
Budin, Francois
Styner, Martin A.
Johnson, G. Allan
Sulik, Kathleen K.
TI Magnetic resonance microscopy-based analyses of the neuroanatomical
effects of gestational day 9 ethanol exposure in mice
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Article
DE Fetal alcohol spectrum disorder; MRI; Mouse; Brain; Ethanol; Shape
analysis
ID FETAL ALCOHOL SYNDROME; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
INDUCED BRAIN ABNORMALITIES; SPECTRUM DISORDERS; ACUTE INSULT; MOUSE
MODEL; CHILDREN; ASYMMETRY; MALFORMATIONS; AUTISM
AB Animal model-based studies have shown that ethanol exposure during early gestation induces developmental stage-specific abnormalities of the face and brain. The exposure time-dependent variability in ethanol's teratogenic outcomes is expected to contribute significantly to the wide spectrum of effects observed in humans with fetal alcohol spectrum disorder (FASD). The work presented here employs a mouse FASD model and magnetic resonance microscopy (MRM; high resolution magnetic resonance imaging) in studies designed to further our understanding of the developmental stage-specific defects of the brain that are induced by ethanol. At neurulation stages, i.e. at the beginning of gestational day (GD) 9 and again 4 hours later, time-mated C57B1/6J dams were intraperitoneally administered 2.9 g/kg ethanol or vehicle. Ethanol-exposed fetuses were collected on GD 17, processed for MRM analysis, and results compared to comparably staged controls. Linear and volume measurements as well as shape changes for numerous individual brain regions were determined. GD 9 ethanol exposure resulted in significantly increased septal region width, reduction of cerebellar volume, and enlargement of all of the ventricles. Additionally, the results of shape analyses showed that many areas of the ethanol-exposed brains including the cerebral cortex, hippocampus and right striatum were significantly misshapen. These data demonstrate that ethanol can induce dysmorphology that may not be obvious based on volumetric analyses alone, highlight the asymmetric aspects of ethanol-induced defects, and add to our understanding of ethanol's developmental stage-dependent neuroteratogenesis. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Parnell, Scott E.; Holloway, Hunter T.; O'Leary-Moore, Shonagh K.; Dehart, Deborah B.; Sulik, Kathleen K.] Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27509 USA.
[Parnell, Scott E.; Dehart, Deborah B.; Sulik, Kathleen K.] Univ N Carolina, Dept Cell Biol & Physiol, Chapel Hill, NC 27509 USA.
[O'Leary-Moore, Shonagh K.; Paniaqua, Beatriz; Oguz, Ipek; Budin, Francois; Styner, Martin A.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27509 USA.
[Oguz, Ipek; Styner, Martin A.] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27509 USA.
[Paniaqua, Beatriz; Oguz, Ipek; Budin, Francois; Styner, Martin A.; Sulik, Kathleen K.] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27509 USA.
[Johnson, G. Allan] Duke Univ, Ctr Vivo Microscopy, Durham, NC USA.
RP Parnell, SE (reprint author), Univ N Carolina, Sch Med, Bowles Ctr Alcohol Studies, CB 7178, Chapel Hill, NC 27509 USA.
EM sparnell@med.unc.edu
FU National Institute on Alcohol Abuse and Alcoholism/NIH [U01-AA017124,
U01-AA0216521, P60-AA011605, K99/R00-AA018697]; NIBIB [U54-EB005149-01];
NICHD [P30-HD03110]
FX This study was conducted at the UNC Bowles Center for Alcohol Studies as
part of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders
and as part of the Carolina Institute for Developmental Disabilities. It
was funded by grant nos. U01-AA017124, U01-AA0216521 and P60-AA011605 to
KKS and grant K99/R00-AA018697 to SEP from the National Institute on
Alcohol Abuse and Alcoholism/NIH; and by NIBIB grant U54-EB005149-01 and
NICHD grant P30-HD03110 to MAS. MRM scanning was performed at the Duke
Center for In Vivo Microscopy, an NIH/NIBIB National Biomedical
Technology Resource Center (P41-EB015897). The content of this
publication is solely the responsibility of the authors and does not
necessarily represent the official views of the National Institutes of
Health.
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NR 41
TC 3
Z9 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
EI 1872-9738
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD SEP-OCT
PY 2013
VL 39
BP 77
EP 83
DI 10.1016/j.ntt.2013.07.009
PG 7
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 246SE
UT WOS:000326558600010
PM 23911654
ER
PT J
AU Ohtake, Y
Kawai, M
Takeuchi, A
Utsumi, K
AF Ohtake, Yoshihisa
Kawai, Masae
Takeuchi, Ai
Utsumi, Kimiko
TI Effects of Video Self-modelling Interventions on Reducing Task Avoidance
Behaviours of Students with Autism Spectrum Disorders
SO INTERNATIONAL JOURNAL OF DISABILITY DEVELOPMENT AND EDUCATION
LA English
DT Article
DE applied behaviour analysis; autism spectrum disorders; avoidance;
elementary; functional behaviour; instruction; video self-modelling;
visual support
ID CHILDREN
AB This study investigated the effects of video self-modelling (VSM) on reducing task avoidance behaviours of four elementary-aged students with autism spectrum disorders. A multiple-probe design across participants showed that the performance of two of the four participants was positively changed immediately after the VSM interventions were implemented. The performance of one participant did not change positively until the original VSM was modified. The performance of another participant was not improved even after the modified VSM was implemented. In addition, improved attentiveness to the video did not necessarily lead to positive effects of the VSM interventions.
C1 [Ohtake, Yoshihisa] Okayama Univ, Okayama, Japan.
[Kawai, Masae] Tobi Special Sch, Okayama, Japan.
[Takeuchi, Ai] Okayama Univ, Fac Educ, Special Sch, Okayama, Japan.
[Utsumi, Kimiko] Ashiya Special Sch, Ashiya, Japan.
RP Ohtake, Y (reprint author), Okayama Univ, Okayama, Japan.
EM ohtake@okayama-u.ac.jp
CR American Psychiatric Association, 2000, DIAGNOSTIC AND STATI
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NR 19
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1034-912X
EI 1465-346X
J9 INT J DISABIL DEV ED
JI Int. J. Disabil. Dev. Educ.
PD SEP 1
PY 2013
VL 60
IS 3
BP 225
EP 241
DI 10.1080/1034912X.2013.812186
PG 17
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 243XO
UT WOS:000326351900004
ER
PT J
AU Pierce, JM
Spriggs, AD
Gast, DL
Luscre, D
AF Pierce, Janelle M.
Spriggs, Amy D.
Gast, David L.
Luscre, Deanna
TI Effects of Visual Activity Schedules on Independent Classroom
Transitions for Students with Autism
SO INTERNATIONAL JOURNAL OF DISABILITY DEVELOPMENT AND EDUCATION
LA English
DT Article
DE autism; centre activities; on-task; on-schedule; picture schedules;
primary grades; transitions; visual schedules
ID PHOTOGRAPHIC ACTIVITY SCHEDULES; PICTURE ACTIVITY SCHEDULES;
ON-SCHEDULE; CHILDREN; DISABILITIES; ENGAGEMENT; BEHAVIORS; TASK;
ACQUISITION; PACKAGE
AB The purpose of this study was to evaluate the effectiveness of visual activity schedules on the behaviour of four students with moderate autism during transitions within a self-contained classroom. Generalisation measures included pre-tests and post-tests with novel stimuli and novel visual activity schedule pictures. This A-B-A-B withdrawal design study replicated and expanded parts of a study by MacDuff, Krantz, and McClannahan and another by Bryan and Gast. Students were trained to use visual activity schedules using the system of least prompts. Results indicated that, in the presence of visual activity schedules, all participants increased independence during transitions. Pre-test/post-test data revealed generalisation of visual activity schedules with novel stimuli and novel visual activity schedule pictures across participants. Implications for practitioners and for future research are discussed.
C1 [Pierce, Janelle M.; Luscre, Deanna] Gwinnett Cty Publ Sch, Suwanee, GA USA.
[Spriggs, Amy D.] Univ Kentucky, Lexington, KY USA.
[Gast, David L.] Univ Georgia, Athens, GA 30602 USA.
RP Spriggs, AD (reprint author), Univ Kentucky, Lexington, KY USA.
EM amy.spriggs@uky.edu
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NR 34
TC 2
Z9 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1034-912X
EI 1465-346X
J9 INT J DISABIL DEV ED
JI Int. J. Disabil. Dev. Educ.
PD SEP 1
PY 2013
VL 60
IS 3
BP 253
EP 269
DI 10.1080/1034912X.2013.812191
PG 17
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 243XO
UT WOS:000326351900006
ER
PT J
AU Blaas, S
AF Blaas, Sabrina
TI Autism and understanding
SO INTERNATIONAL JOURNAL OF DISABILITY DEVELOPMENT AND EDUCATION
LA English
DT Book Review
C1 [Blaas, Sabrina] Univ Queensland, Brisbane, Qld, Australia.
RP Blaas, S (reprint author), Univ Queensland, Brisbane, Qld, Australia.
EM sabrinadianablaas@gmail.com
RI Blaas, Sabrina/D-6805-2015
OI Blaas, Sabrina/0000-0003-4728-5122
CR Solomon W., 2012, AUTISM UNDERSTANDING
NR 1
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1034-912X
EI 1465-346X
J9 INT J DISABIL DEV ED
JI Int. J. Disabil. Dev. Educ.
PD SEP 1
PY 2013
VL 60
IS 3
BP 288
EP 290
DI 10.1080/1034912X.2013.813789
PG 3
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 243XO
UT WOS:000326351900010
ER
PT J
AU Ohya, Y
Narita, M
Futamura, M
Hamaguchi, M
Yamamoto, K
Tsumura, Y
Nomura, I
Kitazawa, H
Morita, K
Kawaguchi, T
Yomase, M
Saito, H
AF Ohya, Y.
Narita, M.
Futamura, M.
Hamaguchi, M.
Yamamoto, K.
Tsumura, Y.
Nomura, I
Kitazawa, H.
Morita, K.
Kawaguchi, T.
Yomase, M.
Saito, H.
CA T-Child Study Grp
TI Association between childhood asthma and autism spectrum disorders
SO ALLERGY
LA English
DT Meeting Abstract
CT World Allergy and Asthma Congress of the
European-Academy-of-Allergy-and-Clinical-Immunology and
World-Allergy-Organization
CY JUN 22-26, 2013
CL Milan, ITALY
SP European Acad Allergy & Clin Immunol, World Allergy Org
C1 [Ohya, Y.; Narita, M.; Futamura, M.; Hamaguchi, M.; Yamamoto, K.; Tsumura, Y.; Nomura, I; Kitazawa, H.; Morita, K.; Kawaguchi, T.; Yomase, M.; Saito, H.; T-Child Study Grp] Natl Ctr Child Hlth & Dev, Div Allergy, Tokyo, Japan.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0105-4538
EI 1398-9995
J9 ALLERGY
JI Allergy
PD SEP
PY 2013
VL 68
SU 97
SI SI
BP 451
EP 451
PG 1
WC Allergy; Immunology
SC Allergy; Immunology
GA 227VH
UT WOS:000325142904094
ER
PT J
AU Borody, TJ
Peattie, D
Campbell, J
AF Borody, Thomas J.
Peattie, Debra
Campbell, Jordana
TI Therapeutic Potential of the Human Gastrointestinal Microbiome
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Article
DE microbiome; Clostridium difficile; microbiota; fecal microbiota
transplantation; probiotics
ID ESCHERICHIA-COLI EXTRACT; DIFFICILE-ASSOCIATED DIARRHEA;
URINARY-TRACT-INFECTIONS; FECAL MICROBIOTA; GUT MICROBIOTA; INTESTINAL
MICROBIOTA; ONSET AUTISM; DOUBLE-BLIND; TRANSPLANTATION; OM-89
AB Abstract
Scientific breakthroughs in deciphering the human gut microbiome and the clinical success of fecal microbiota transplantation (FMT) to treat recurrent Clostridium difficile infection (R-CDI) are driving therapeutic advances based on human gut microbiota. Due to the powerful therapeutic capacity of FMT and the keen interest for FMT-related products approved by regulatory agencies it is timely to review the growing field of therapeutics rooted in the human microbiome, emphasizing FMT but also considering probiotics, vaccines, bacteriophages, and bioactive products. The diminishing effectiveness of antibiotics and the increasing rates of antibiotic resistance have renewed interest in finding alternative methods to combat bacterial infections. Despite pharmaceutical investment in developing new and more effective antibiotics, infectious disease experts warn of a compelling need to develop antibacterial agents distinct from antibiotics. Probiotics have been recognized as beneficial to human health for over one hundred years. The most powerful probiotic of all, the gastrointestinal microbiota, houses approximately 100 trillion species of bacteria, many of which produce a wealth of potent components, such as antimicrobial bacteriocins, metabolites, vitamins, and bacteriophages. The success of human gut microbiota in treating R-CDI and restoring gut homeostasis has highlighted the power of "nature's complete probiotic" and is propelling fecal microbiota along a therapeutic biologic regulatory path. Clinical use of FMT in R-CDI has also taught us that other conditions, e.g., ulcerative colitis, characterized by superinfected and dysbiotic microbiomes may benefit from restoring gut homeostasis with normal microbiota, leading to active efforts to develop therapeutics from the human gut microbiome.
C1 [Borody, Thomas J.; Campbell, Jordana] Ctr Digest Dis, Five Dock, NSW 2046, Australia.
[Peattie, Debra] Pleiades Advisors, Lincoln, MA 01773 USA.
RP Borody, TJ (reprint author), Ctr Digest Dis, Level 1-229 Great North Rd, Five Dock, NSW 2046, Australia.
EM thomas.borody@cdd.com.au
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NR 61
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4391
EI 1098-2299
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD SEP
PY 2013
VL 74
IS 6
SI SI
BP 385
EP 392
DI 10.1002/ddr.21093
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 218CP
UT WOS:000324410500007
ER
PT J
AU Bryant, L
Coffey, A
Povinelli, DJ
Pruett, JR
AF Bryant, Lauren
Coffey, Anna
Povinelli, Daniel J.
Pruett, John R., Jr.
TI Theory of Mind experience sampling in typical adults
SO CONSCIOUSNESS AND COGNITION
LA English
DT Article
DE Theory of Mind; Experience sampling; Social cognition; Folk psychology
ID EXECUTIVE FUNCTION; SOCIAL COGNITION; FALSE BELIEF; AUTISM; CHILDREN;
SCHIZOPHRENIA; IMPAIRMENTS; ATTENTION; AWARENESS; LANGUAGE
AB We explored the frequency with which typical adults make Theory of Mind (ToM) attributions, and under what circumstances these attributions occur. We used an experience sampling method to query 30 typical adults about their everyday thoughts. Participants carried a Personal Data Assistant (PDA) that prompted them to categorize their thoughts as Action, Mental State, or Miscellaneous at approximately 30 pseudo-random times during a continuous 10-h period. Additionally, participants noted the direction of their thought (self versus other) and degree of socializing (with people versus alone) at the time of inquiry. We were interested in the relative frequency of ToM (mental state attributions) and how prominent they were in immediate social exchanges. Analyses of multiple choice answers suggest that typical adults: (1) spend more time thinking about actions than mental states and miscellaneous things, (2) exhibit a higher degree of own- versus other-directed thought when alone, and (3) make mental state attributions more frequently when not interacting (offline) than while interacting with others (online). A significant 3-way interaction between thought type, direction of thought, and socializing emerged because action but not mental state thoughts about others occurred more frequently when participants were interacting with people versus when alone; whereas there was an increase in the frequency of both action and mental state attributions about the self when participants were alone as opposed to socializing. A secondary analysis of coded free text responses supports findings 1-3. The results of this study help to create a more naturalistic picture of ToM use in everyday life and the method shows promise for future study of typical and atypical thought processes. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Bryant, Lauren; Coffey, Anna] Washington Univ, St Louis, MO 63130 USA.
[Povinelli, Daniel J.] Univ Louisiana, Dept Biol, Lafayette, LA 70504 USA.
[Pruett, John R., Jr.] Washington Univ, Dept Psychiat, Sch Med, St Louis, MO 63110 USA.
[Coffey, Anna] St Olaf Coll, Northfield, MN 55057 USA.
RP Bryant, L (reprint author), Washington Univ, 1 Brookings Dr, St Louis, MO 63130 USA.
EM lauren.k.bryant@vanderbilt.edu; meridian.coffey@gmail.com;
djp3463@louisiana.edu; pruettj@psychiatry.wustl.edu
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NR 44
TC 2
Z9 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8100
EI 1090-2376
J9 CONSCIOUS COGN
JI Conscious. Cogn.
PD SEP
PY 2013
VL 22
IS 3
BP 697
EP 707
DI 10.1016/j.concog.2013.04.005
PG 11
WC Psychology, Experimental
SC Psychology
GA 235SG
UT WOS:000325740400003
PM 23685620
ER
PT J
AU Crisan, C
Stan, C
AF Crisan, Claudia
Stan, Cristian
TI THE EFFICIENCY OF LCSMA IN REDUCING CHALLENGING BEHAVIORS IN CHILDREN
WITH AUTISM
SO JOURNAL OF COGNITIVE AND BEHAVIORAL PSYCHOTHERAPIES
LA English
DT Article
DE autism; challenging behaviors; LCSMA; language developmental stage
ID SOCIAL-COMMUNICATIVE BEHAVIOR
AB The present study, based on three longitudinal case studies, investigated the relationship between language developmental stage and challenging behaviors exhibited by children with autism with the purpose of expressing refusal. Participants received an intervention based on language and communication stimulation addressed to children with autism spectrum disorder (LCSMA, Dascal Crisan, 2012). Results confirm the correlation between language developmental stage and the presence of challenging behaviors, respectively the lack of functional communication skills determines a more frequent display of maladaptive behaviors. Our results also prove the efficiency of the method in the case of the 3 participants included in the study. They acquired functional communication skills to express refusal, an acquisitions that facilitated a significant reduction in the frequency of challenging behaviors.
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RP Crisan, C (reprint author), Univ Babes Bolyai, R-3400 Cluj Napoca, Romania.
EM claudia.crisan@ubbcluj.ro
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NR 34
TC 0
Z9 0
PU INT INST ADVANCED STUDIES PSYCHOTHERAPY & APPLIED MENTAL HEALTH
PI CLUJ
PA NO 37 , REPUBLICII STR, CLUJ-NAPOCA, CLUJ, 00000, ROMANIA
SN 1584-7101
EI 2068-7621
J9 J COGN BEHAV PSYCHOT
JI J. Cogn. Behav. Psychother.
PD SEP
PY 2013
VL 13
IS 2
BP 421
EP 435
PG 15
WC Psychology, Clinical
SC Psychology
GA 239XH
UT WOS:000326058800013
ER
PT J
AU Agranoff, R
AF Agranoff, Robert
TI The Transformation of Public Sector Intellectual/Developmental
Disabilities Programming
SO PUBLIC ADMINISTRATION REVIEW
LA English
DT Article
AB Programming for persons with intellectual and developmental disabilities has shifted from state institutional care to community-based services, facilitated by federal government support as well as services delivered by nongovernmental organizations (NGOs). For persons with mental retardation, epilepsy, cerebral palsy, and autism, these programs not only have moved into the health care orbit but also are in search of more holistic ways to maintain persons with their families and in communities. Three major forces have led to this shift: federal financing, particularly under Medicaid; integration of services around clients; and externalized service delivery by NGOs. These are increasingly connected forces, facilitated particularly by the Medicaid Home and Community-Based Services Waiver. They have transformed state-operated systems. Increasingly, states are working with NGO case management and service delivery providers to organize and integrate services to face this continuing challenge.
C1 Indiana Univ Bloomington, Sch Publ & Environm Affairs, Bloomington, IN 47405 USA.
RP Agranoff, R (reprint author), Indiana Univ Bloomington, Sch Publ & Environm Affairs, Bloomington, IN 47405 USA.
EM agranoff@indiana.edu
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0033-3352
EI 1540-6210
J9 PUBLIC ADMIN REV
JI Public Adm. Rev.
PD SEP
PY 2013
VL 73
SU 1
SI SI
BP S127
EP S138
DI 10.1111/puar.12101
PG 12
WC Public Administration
SC Public Administration
GA 217VY
UT WOS:000324391800017
ER
PT J
AU Pratt, KG
Khakhalin, AS
AF Pratt, Kara G.
Khakhalin, Arseny S.
TI Modeling human neurodevelopmental disorders in the Xenopus tadpole: from
mechanisms to therapeutic targets
SO DISEASE MODELS & MECHANISMS
LA English
DT Review
ID AUTISM SPECTRUM DISORDERS; SINGLE-CELL ELECTROPORATION; DEVELOPING
VISUAL-SYSTEM; RETINAL GANGLION-CELLS; AXON BRANCH DYNAMICS; ACTIVITY
IN-VIVO; OPTIC TECTUM; FRAGILE-X; LAEVIS TADPOLES; RETT-SYNDROME
AB The Xenopus tadpole model offers many advantages for studying the molecular, cellular and network mechanisms underlying neurodevelopmental disorders. Essentially every stage of normal neural circuit development, from axon outgrowth and guidance to activity-dependent homeostasis and refinement, has been studied in the frog tadpole, making it an ideal model to determine what happens when any of these stages are compromised. Recently, the tadpole model has been used to explore the mechanisms of epilepsy and autism, and there is mounting evidence to suggest that diseases of the nervous system involve deficits in the most fundamental aspects of nervous system function and development. In this Review, we provide an update on how tadpole models are being used to study three distinct types of neurodevelopmental disorders: diseases caused by exposure to environmental toxicants, epilepsy and seizure disorders, and autism.
C1 [Pratt, Kara G.] Univ Wyoming, Laramie, WY 82071 USA.
[Khakhalin, Arseny S.] Brown Univ, Providence, RI 02912 USA.
RP Pratt, KG (reprint author), Univ Wyoming, Laramie, WY 82071 USA.
EM kpratt4@uwyo.edu
FU National Institute of General Medical Sciences [P30 GM103398]; National
Institutes of Health; [NIH R01 EY019578-03]
FX K.G.P. is supported by a grant from the National Institute of General
Medical Sciences (P30 GM103398) from the National Institutes of Health.
A.S.K. is funded by NIH R01 EY019578-03 grant (PI: Carlos Aizenman).
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NR 151
TC 8
Z9 8
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
CAMBS, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD SEP
PY 2013
VL 6
IS 5
BP 1057
EP 1065
DI 10.1242/dmm.012138
PG 9
WC Cell Biology; Pathology
SC Cell Biology; Pathology
GA 236IV
UT WOS:000325789600002
PM 23929939
ER
PT J
AU Magri, L
Cominelli, M
Cambiaghi, M
Cursi, M
Leocani, L
Minicucci, F
Poliani, PL
Galli, R
AF Magri, Laura
Cominelli, Manuela
Cambiaghi, Marco
Cursi, Marco
Leocani, Letizia
Minicucci, Fabio
Poliani, Pietro Luigi
Galli, Rossella
TI Timing of mTOR activation affects tuberous sclerosis complex
neuropathology in mouse models
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
ID TSC1; CELLS; PREVALENCE; EXPRESSION; FOREBRAIN; MUTATIONS; PHENOTYPE;
RAPAMYCIN; DEFICITS; NEURONS
AB Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidity, and is caused by mutations in either of two genes, TSC1 or TSC2. Most affected individuals display severe neurological manifestations - such as intractable epilepsy, mental retardation and autism - that are intimately associated with peculiar CNS lesions known as cortical tubers (CTs). The existence of a significant genotype-phenotype correlation in individuals bearing mutations in either TSC1 or TSC2 is highly controversial. Similar to observations in humans, mouse modeling has suggested that a more severe phenotype is associated with mutation in Tsc2 rather than in Tsc1. However, in these mutant mice, deletion of either gene was achieved in differentiated astrocytes. Here, we report that loss of Tsc1 expression in undifferentiated radial glia cells (RGCs) early during development yields the same phenotype detected upon deletion of Tsc2 in the same cells. Indeed, the same aberrations in cortical cytoarchitecture, hippocampal disturbances and spontaneous epilepsy that have been detected in RGC-targeted Tsc2 mutants were observed in RGC-targeted Tsc1 mutant mice. Remarkably, thorough characterization of RGC-targeted Tsc1 mutants also highlighted subventricular zone (SVZ) disturbances as well as STAT3-dependent and -independent developmental-stage-specific defects in the differentiation potential of ex-vivo-derived embryonic and postnatal neural stem cells (NSCs). As such, deletion of either Tsc1 or Tsc2 induces mostly overlapping phenotypic neuropathological features when performed early during neurogenesis, thus suggesting that the timing of mTOR activation is a key event in proper neural development.
C1 [Magri, Laura; Galli, Rossella] Ist Sci San Raffaele, Div Regenerat Med Stem Cells & Gene Therapy, Neural Stem Cell Biol Unit, I-20132 Milan, Italy.
[Cominelli, Manuela; Poliani, Pietro Luigi] Univ Brescia, Spedali Civili Brescia, Dept Mol & Translat Med, Pathol Unit, I-25124 Brescia, Italy.
[Cambiaghi, Marco; Cursi, Marco; Leocani, Letizia; Minicucci, Fabio] Ist Sci San Raffaele, Inst Expt Neurol INSPE, Expt Neurophysiol Unit, I-20132 Milan, Italy.
RP Galli, R (reprint author), Ist Sci San Raffaele, Div Regenerat Med Stem Cells & Gene Therapy, Neural Stem Cell Biol Unit, Via Olgettina 58, I-20132 Milan, Italy.
EM galli.rossella@hsr.it
FU Associazione Sclerosi Tuberosa (AST)
FX This work was supported by Associazione Sclerosi Tuberosa (AST) to R.G.
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NR 23
TC 4
Z9 4
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
CAMBS, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD SEP
PY 2013
VL 6
IS 5
BP 1185
EP 1197
DI 10.1242/dmm.012096
PG 13
WC Cell Biology; Pathology
SC Cell Biology; Pathology
GA 236IV
UT WOS:000325789600014
PM 23744272
ER
PT J
AU Dalsgaard, S
Nielsen, HS
Simonsen, M
AF Dalsgaard, Soren
Nielsen, Helena Skyt
Simonsen, Marianne
TI Five-Fold Increase in National Prevalence Rates of
Attention-Deficit/Hyperactivity Disorder Medications for Children and
Adolescents with Autism Spectrum Disorder,
Attention-Deficit/Hyperactivity Disorder, and other Psychiatric
Disorders: A Danish Register-Based Study
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; DEFICIT-HYPERACTIVITY DISORDER;
DRUG-USE; PATTERNS; METHYLPHENIDATE; PHARMACOTHERAPY; PERSPECTIVE;
INATTENTION; BEHAVIOR; COUNTY
AB Objective: The purpose of this study was to estimate the prevalence and time trends in prescriptions of methylphenidate, dexamphetamine, and atomoxetine in children and adolescents, within three diagnostic groups: 1) autism spectrum disorder (ASD), 2) attention-deficit/hyperactivity disorder (ADHD), and 3) other psychiatric disorders. Methods: Data from six different national registers were used and merged to identify a cohort of all children and adolescents born in Denmark between 1990 and 2001 (n=852,711). Sociodemographic covariates on cohort members and their parents and lifetime prescriptions of methylphenidate, dexamphetamine, and atomoxetine were extracted from the registers. Prescriptions were also stratified by duration (<6 months. vs.6 months). Results: Sixteen percent of 9698 children and adolescents with ASD (n=1577), 61% of 11,553 children and adolescents with ADHD (n=7021) and 3% of 48,468 children and adolescents with other psychiatric disorders (n=1537) were treated with one or more ADHD medications. There was a significant increase in prescription rates of these medications for all three groups. From 2003 to 2010, youth 6-13 years of age with ASD, ADHD, and other psychiatric disorders had 4.7-fold (4.4-4.9), 6.3-fold (6.0-6.4), and 5.5-fold (5.0-5.9) increases, respectively, in prescription rates of ADHD medications. Conclusion: This is the largest study to date assessing stimulant treatment in children and adolescents with ASD, and is the first prospective study quantifying the change over time in the prevalence of treatment with ADHD medications in a population-based national cohort of children and adolescents with ASD. The prevalence of stimulant treatment in youth with ASD of 16% is consistent with earlier studies. The past decade has witnessed a clear and progressive increase in the prescription rates of medications typically used to treat ADHD in children and adolescents in Denmark. This increase is not limited to only those with ADHD, but includes others with neuropsychiatric disorders, including ASD. The risks and benefits of this practice await further study.
C1 [Dalsgaard, Soren; Nielsen, Helena Skyt; Simonsen, Marianne] Aarhus Univ, Sch Business & Social Sci, Dept Econ & Business, Natl Ctr Register Based Res, DK-8210 Aarhus V, Denmark.
[Dalsgaard, Soren] Lundbeck Fdn Initiat Integrat Psychiat Res, IPSYCH, Aarhus, Denmark.
[Dalsgaard, Soren] Lundbeck Fdn Initiat Integrat Psychiat Res, IPSYCH, Copenhagen, Denmark.
[Dalsgaard, Soren] Hosp Telemark, Dept Child & Adolescent Psychiat, Kragero, Norway.
RP Dalsgaard, S (reprint author), Aarhus Univ, Sch Business & Social Sci, Dept Econ & Business, Natl Ctr Register Based Res, Fuglesangs Alle 4,Bldg K, DK-8210 Aarhus V, Denmark.
EM sdalsgaard@ncrr.dk
FU Danish Council for Independent Research [10-079597]; Slagtermester
Worzner og Hustru Inger Worzners mindelegat til fordel for forskning af
sindslidelser
FX The study was funded by grants from the Danish Council for Independent
Research (Sapere Aude Starting Grant, 10-079597) and "Slagtermester
Worzner og Hustru Inger Worzners mindelegat til fordel for forskning af
sindslidelser."
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NR 34
TC 15
Z9 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD SEP 1
PY 2013
VL 23
IS 7
BP 432
EP 439
DI 10.1089/cap.2012.0111
PG 8
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 218WN
UT WOS:000324463300002
PM 24015896
ER
PT J
AU Kondapalli, KC
Hack, A
Schushan, M
Landau, M
Ben-Tal, N
Rao, R
AF Kondapalli, Kalyan C.
Hack, Anniesha
Schushan, Maya
Landau, Meytal
Ben-Tal, Nir
Rao, Rajini
TI Functional evaluation of autism-associated mutations in NHE9
SO NATURE COMMUNICATIONS
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; NA+/H+ EXCHANGER ISOFORM-6;
LINKED MENTAL-RETARDATION; VESICLE TRAFFICKING; TRANSPORT MECHANISM;
ANGELMAN-SYNDROME; PH REGULATION; YEAST; ANTIPORTER; EPILEPSY
AB NHE9 (SLC9A9) is an endosomal cation/proton antiporter with orthologues in yeast and bacteria. Rare, missense substitutions in NHE9 are genetically linked with autism but have not been functionally evaluated. Here we use evolutionary conservation analysis to build a model structure of NHE9 based on the crystal structure of bacterial NhaA and use it to screen autism-associated variants in the human population first by phenotype complementation in yeast, followed by functional analysis in primary cortical astrocytes from mouse. NHE9-GFP localizes to recycling endosomes, where it significantly alkalinizes luminal pH, elevates uptake of transferrin and the neurotransmitter glutamate, and stabilizes surface expression of transferrin receptor and GLAST transporter. In contrast, autism-associated variants L236S, S438P and V176I lack function in astrocytes. Thus, we establish a neurobiological cell model of a candidate gene in autism. Loss-of-function mutations in NHE9 may contribute to autistic phenotype by modulating synaptic membrane protein expression and neurotransmitter clearance.
C1 [Kondapalli, Kalyan C.; Hack, Anniesha; Rao, Rajini] Johns Hopkins Univ Hosp, Sch Med, Dept Physiol, Baltimore, MD 21205 USA.
[Schushan, Maya; Ben-Tal, Nir] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem & Mol Biol, IL-69978 Tel Aviv, Israel.
[Landau, Meytal] Technion Israel Inst Technol, Dept Biol, IL-32000 Haifa, Israel.
RP Rao, R (reprint author), Johns Hopkins Univ Hosp, Sch Med, Dept Physiol, 725 North Wolfe St, Baltimore, MD 21205 USA.
EM rrao@jhmi.edu
RI landau, Meytal/J-3075-2012
FU NIH [R01 DK054214]; American Heart Association [11POST7380034]; American
Physiological Society Porter Physiology Development Predoctoral
Fellowship; I-CORE Program of the Planning and Budgeting Committee;
Israel Science Foundation [1775/12]; Edmond J. Safra Center for
Bioinformatics at Tel Aviv University
FX We thank Jeffrey D. Rothstein for help with astrocyte cultures and
antibodies. This work was supported by grants NIH R01 DK054214 (to
R.R.), American Heart Association Grant 11POST7380034 (to K.C.K.) and
American Physiological Society Porter Physiology Development Predoctoral
Fellowship (A.H.). MS, ML and NB-T acknowledge the support of the I-CORE
Program of the Planning and Budgeting Committee and The Israel Science
Foundation (grant No 1775/12). MS and NB-T also acknowledge the support
of the Edmond J. Safra Center for Bioinformatics at Tel Aviv University.
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NR 61
TC 7
Z9 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD SEP
PY 2013
VL 4
AR 2510
DI 10.1038/ncomms3510
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 233AC
UT WOS:000325535300002
PM 24065030
ER
PT J
AU Gil, M
Bhatt, R
Picotte, KB
Hull, EM
AF Gil, Mario
Bhatt, Renu
Picotte, Katie B.
Hull, Elaine M.
TI Sexual experience increases oxytocin receptor gene expression and
protein in the medial preoptic area of the male rat
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Oxytocin; Oxytocin receptor; Sexual behavior; Sexual experience; Medial
preoptic area; Hypothalamus; Rats
ID VENTRAL TEGMENTAL AREA; PENILE ERECTION; PARAVENTRICULAR NUCLEUS;
MATERNAL-BEHAVIOR; NITRIC-OXIDE; EXTRACELLULAR DOPAMINE; FEMALE RATS;
SOCIAL COGNITION; AGGRESSION; ACCUMBENS
AB Oxytocin (OT) promotes social and reproductive behaviors in mammals, and OT deficits may be linked to disordered social behaviors like autism and severe anxiety. Male rat sexual behavior is an excellent model for OT regulation of behavior, as its pattern and neural substrates are well characterized. We previously reported that OT microinjected into the medial preoptic area (MPOA), a major integrative site for male sexual behavior, facilitates copulation in sexually experienced male rats, whereas intra-MPOA injection of an OT antagonist (OTA) inhibits copulation. In the present studies, copulation on the day of sacrifice stimulated OTR mRNA expression in the MPOA, irrespective of previous sexual experience, with the highest levels observed in first-time copulators. In addition, sexually experienced males had higher levels of OTR protein in the MPOA than sexually naive males and first-time copulators. Finally, intra-MPOA injection of OT facilitated mating in sexually naive males. Others have reported a positive correlation between OT mRNA levels and male sexual behavior. Our studies show that OT in the MPOA facilitates mating in both sexually naive and experienced males, some of the behavioral effects of OT are mediated by the OTR, and sexual experience is associated with increased OTR expression in the MPOA. Taken together, these data suggest a reciprocal interaction between central OT and behavior, in which OT facilitates copulation and copulation stimulates the OT/OTR system in the brain. (C) 2013 Elsevier Ltd. All rights reserved.
C1 Florida State Univ, Dept Psychol, Tallahassee, FL 32306 USA.
Florida State Univ, Program Neurosci, Tallahassee, FL 32306 USA.
RP Gil, M (reprint author), Georgia State Univ, Neurosci Inst, Atlanta, GA 30309 USA.
EM mgil@gsu.edu
FU NIH [MH040826]
FX This work was supported by NIH grant MH040826 to EMH and was part of the
PhD dissertation of MG.
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NR 56
TC 6
Z9 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2013
VL 38
IS 9
BP 1688
EP 1697
DI 10.1016/j.psyneuen.2013.02.002
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 228LM
UT WOS:000325188300023
PM 23474276
ER
PT J
AU Parr, LA
Modi, M
Siebert, E
Young, LJ
AF Parr, Lisa A.
Modi, Meera
Siebert, Erin
Young, Larry J.
TI Intranasal oxytocin selectively attenuates rhesus monkeys' attention to
negative facial expressions
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Oxytocin; Attention; Gaze; Facial expression; Social cognition; Autism
ID EMOTIONAL FACES; NEURAL CIRCUITRY; SOCIAL-BEHAVIOR; BRAIN OXYTOCIN;
HUMANS; AMYGDALA; RESPONSES; MEMORY; DISORDERS; STIMULI
AB Intranasal oxytocin (IN-OT) modulates social perception and cognition in humans and could be an effective pharmacotherapy for treating social impairments associated with neuropsychiatric disorders, like autism. However, it is unknown how IN-OT modulates social cognition, its effect after repeated use, or its impact on the developing brain. Animal models are urgently needed. This study examined the effect of IN-OT on social perception in monkeys using tasks that reveal some of the social impairments seen in autism. Six rhesus macaques (Macaca mulatta, 4 males) received a 48 IU dose of OT or saline placebo using a pediatric nebulizer. An hour later, they performed a computerized task (the dot-probe task) to measure their attentional bias to social, emotional, and nonsocial images. Results showed that IN-OT significantly reduced monkeys' attention to negative facial expressions, but not neutral faces or clip art images and, additionally, showed a trend to enhance monkeys' attention to direct vs. averted gaze faces. This study is the first to demonstrate an effect of IN-OT on social perception in monkeys, IN-OT selectively reduced monkey's attention to negative facial expressions, but not neutral social or nonsocial images. These findings complement several reports in humans showing that IN-OT reduces the aversive quality of social images suggesting that, like humans, monkey social perception is mediated by the oxytocinergic system. Importantly, these results in monkeys suggest that IN-OT does not dampen the emotional salience of social stimuli, but rather acts to affect the evaluation of emotional images during the early stages of information processing. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Parr, Lisa A.; Young, Larry J.] Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA.
[Parr, Lisa A.; Siebert, Erin; Young, Larry J.] Yerkes Natl Primate Res Ctr, Atlanta, GA USA.
[Parr, Lisa A.; Modi, Meera; Young, Larry J.] Emory Univ, Ctr Translat Social Neurosci, Atlanta, GA 30329 USA.
[Modi, Meera] Pfizer Program Neurosci, Cambridge, MA USA.
RP Parr, LA (reprint author), Emory Univ, Yerkes Natl Primate Res Ctr, 954 Gatewood Rd, Atlanta, GA 30329 USA.
EM lparr@emory.edu
FU National Institutes of Health [MHR01068791]; Emory University; Center
for Translational Social Neuroscience, Emory University; National Center
for Research Resources [P51RR000165]
FX This project was funded by the National Institutes of Health,
MHR01068791 to L.A. Parr, a Neuroscience Initiatives Award from Emory
University to L.J. Young, and the Center for Translational Social
Neuroscience, Emory University. Additional support was provided by the
National Center for Research Resources, P51RR000165 to the Yerkes
National Primate Research Center, currently the Office of Research
Infrastructure Programs/OD P510D011132.
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NR 51
TC 23
Z9 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2013
VL 38
IS 9
BP 1748
EP 1756
DI 10.1016/j.psyneuen.2013.02.011
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 228LM
UT WOS:000325188300029
PM 23490074
ER
PT J
AU Backasch, B
Straube, B
Pyka, M
Klohn-Saghatolislam, F
Muller, MJ
Kircher, TTJ
Leube, DT
AF Backasch, Bianca
Straube, Benjamin
Pyka, Martin
Kloehn-Saghatolislam, Farahnaz
Mueller, Matthias J.
Kircher, Tilo T. J.
Leube, Dirk T.
TI Hyperintentionality during automatic perception of naturalistic
cooperative behavior in patients with schizophrenia
SO SOCIAL NEUROSCIENCE
LA English
DT Review
DE Cooperative behavior; Persecutory delusion; fMRI; Schizophrenia; ToM
ID MIRROR-NEURON SYSTEM; PERSONALITY QUESTIONNAIRE-BRIEF; AUTISM SPECTRUM
DISORDERS; MENTAL STATE ATTRIBUTION; SUPERIOR TEMPORAL SULCUS; SOCIAL
COGNITION; PERSECUTORY DELUSIONS; PSYCHOSIS PRONENESS; INTENTIONAL
MOVEMENT; PREMOTOR CORTEX
AB Social cognition and the corresponding functionality of involved brain networks are essential for effortless social interaction. Patients with schizophrenia exhibit impaired social functioning. In this study, we focused on the neural networks involved in the automatic perception of cooperative behavior and their alterations in schizophrenia.We performed a functional magnetic resonance imaging study of 19 schizophrenia patients and 19 healthy matched controls. Participants watched a set of short videos with two actors manipulating objects, either with (C+) or without cooperation (C-). Additionally, we assessed delusional symptoms in patients using the Scales for the Assessment of Positive Symptoms and psychosis proneness in healthy controls using the brief schizotypal personality questionnaire.The observed group-by-condition interaction revealed a contrasting activation pattern for patients versus healthy controls in the medial and lateral prefrontal cortex, the middle cingulate cortex, and the left angular gyrus. Furthermore, increased activation of the middle prefrontal areas, left angular gyrus, and the posterior sulcus temporalis superior in response to the noncooperative condition (C-) was positively correlated with delusional symptoms in patients.Our findings suggest an overactivated theory of mind network in patients for the processing of noncooperative behavior. Thus, overmentalizing might be based on delusions and altered processing of cooperative behavior in patients with schizophrenia.
C1 [Backasch, Bianca; Straube, Benjamin; Pyka, Martin; Kloehn-Saghatolislam, Farahnaz; Kircher, Tilo T. J.; Leube, Dirk T.] Univ Marburg, Dept Psychiat & Psychotherapy, D-35037 Marburg, Germany.
[Mueller, Matthias J.] Vitos Clin Psychiat & Psychotherapy, Marburg, Germany.
[Leube, Dirk T.] AWO Ctr Psychiat Halle, Clin Psychiat & Psychotherapy, Halle, Germany.
RP Backasch, B (reprint author), Univ Marburg, Dept Psychiat & Psychotherapy, Rudolf Bultmann Str 8, D-35037 Marburg, Germany.
EM bianca.backasch@googlemail.com
RI Straube, Benjamin/K-3126-2012; Muller, Matthias/A-2613-2015
OI Straube, Benjamin/0000-0002-9837-0944; Muller,
Matthias/0000-0002-7577-2748
FU Federal Ministry of Education and Research [BMBF] [FKZ 01GW0751]
FX This work was funded by the Federal Ministry of Education and Research
[BMBF, FKZ 01GW0751]. We are very grateful to Mathias Kauff for very
useful comments on the manuscript and Mechthild Wallnig for her help
with the fMRI data collection. The authors have declared that there are
no conflicts of interest in relation to the subject of this study.
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NR 119
TC 4
Z9 4
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 1747-0919
EI 1747-0927
J9 SOC NEUROSCI-UK
JI Soc. Neurosci.
PD SEP 1
PY 2013
VL 8
IS 5
BP 489
EP 504
DI 10.1080/17470919.2013.820666
PG 16
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 220VD
UT WOS:000324614100009
PM 23895223
ER
PT J
AU Hoenen, M
Schain, C
Pause, BM
AF Hoenen, Matthias
Schain, Cecile
Pause, Bettina M.
TI Down-modulation of mu-activity through empathic top-down processes
SO SOCIAL NEUROSCIENCE
LA English
DT Article
DE Mu-suppression; Empathy; Perspective taking; Electroencephalograpy;
Mirror neurons
ID MIRROR-NEURON SYSTEM; AUTISM SPECTRUM DISORDERS; EEG; SUPPRESSION;
OTHERS; MOTOR; PAIN; OSCILLATIONS; RHYTHMS; ALPHA
AB Simulation theories argue that humans simulate motor processes of others to gain information about intentions and emotional states of others. Mu-suppression is a valid electrophysiological correlate of these processes. Mu-activity can be measured via electroencephalography (EEG) in the alpha-band (8-13Hz) above the sensorimotor cortex and is suppressed when actions are executed or observed. Based on a within-subject design, including 28 participants, it was tested whether the processes measured by mu-suppression could be modulated by empathic top-down-processes. Participants were asked to take the perspective of two actors, telling a story about a sad or neutral life event (video sequences). Afterwards, EEG was measured at central (C3, Cz, C4) and occipital (O1, Oz, O2) electrodes, while participants observed the actors drinking water (standardized video sequences, 8s duration). Fast fourier transformation showed stronger suppression of power in the alpha-range (relative to baseline) at central and occipital electrodes while the actor with the sad story was observed relative to the actor with the neutral story. Furthermore, measures of state empathy correlated positively with the difference of mu-suppression between executed and observed movements, an indicator of self-other discrimination. Thus, mirror neuron activity measured by mu-suppression is modulated by empathic processes.
C1 [Hoenen, Matthias; Pause, Bettina M.] Univ Dusseldorf, Inst Expt Psychol, D-40225 Dusseldorf, Germany.
[Schain, Cecile] Univ Munster, Dept Psychol, D-48149 Munster, Germany.
RP Pause, BM (reprint author), Univ Dusseldorf, Univ Str 1, D-40225 Dusseldorf, Germany.
EM bettina.pause@hhu.de
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NR 41
TC 1
Z9 1
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 1747-0919
EI 1747-0927
J9 SOC NEUROSCI-UK
JI Soc. Neurosci.
PD SEP 1
PY 2013
VL 8
IS 5
BP 515
EP 524
DI 10.1080/17470919.2013.833550
PG 10
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA 220VD
UT WOS:000324614100011
PM 24028313
ER
PT J
AU Dickson, PE
Corkill, B
McKimm, E
Miller, MM
Calton, MA
Goldowitz, D
Blaha, CD
Mittleman, G
AF Dickson, Price E.
Corkill, Beau
McKimm, Eric
Miller, Mellessa M.
Calton, Michele A.
Goldowitz, Daniel
Blaha, Charles D.
Mittleman, Guy
TI Effects of stimulus salience on touchscreen serial reversal learning in
a mouse model of fragile X syndrome
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Fragile X syndrome; Fmr1; Executive function; Behavioral flexibility
ID FMR1 KNOCKOUT MICE; PREFRONTAL SEROTONIN DEPLETION; FUNCTIONAL BRAIN
ACTIVATION; BEHAVIORAL FLEXIBILITY; MENTAL-RETARDATION; COGNITIVE
INFLEXIBILITY; VISUAL-DISCRIMINATION; CEREBELLAR MODULATION;
ORBITOFRONTAL CORTEX; EXECUTIVE FUNCTIONS
AB Fragile X syndrome (FXS) is the most common inherited form of intellectual disability in males and the most common genetic cause of autism. Although executive dysfunction is consistently found in humans with FXS, evidence of executive dysfunction in Fmr1 KO mice, a mouse model of FXS, has been inconsistent. One possible explanation for this is that executive dysfunction in Fmr1 KO mice, similar to humans with FXS, is only evident when cognitive demands are high. Using touchscreen operant conditioning chambers, male Fmr1 KO mice and their male wildtype littermates were tested on the acquisition of a pairwise visual discrimination followed by four serial reversals of the response rule. We assessed reversal learning performance under two different conditions. In the first, the correct stimulus was salient and the incorrect stimulus was non-salient. In the second and more challenging condition, the incorrect stimulus was salient and the correct stimulus was non-salient; this increased cognitive load by introducing conflict between sensory-driven (i.e., bottom-up) and task-dependent (i.e., top-down) signals. Fmr1 KOs displayed two distinct impairments relative to wildtype littermates. First, Fmr1 KOs committed significantly more learning-type errors during the second reversal stage, but only under high cognitive load. Second, during the first reversal stage, Fmrl KOs committed significantly more attempts to collect a reward during the timeout following an incorrect response. These findings indicate that Fmrl KO mice display executive dysfunction that, in some cases, is only evident under high cognitive load. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Dickson, Price E.] Jackson Lab, Bar Harbor, ME 04609 USA.
[Corkill, Beau; McKimm, Eric; Miller, Mellessa M.; Calton, Michele A.; Blaha, Charles D.; Mittleman, Guy] Memphis State Univ, Dept Psychol, Memphis, TN 38152 USA.
[Goldowitz, Daniel] Univ British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Vancouver, BC, Canada.
RP Mittleman, G (reprint author), Memphis State Univ, Dept Psychol, Memphis, TN 38152 USA.
EM gmittlmn@memphis.edu
FU NINDS [1R01NS063009]
FX This project was made possible by NINDS grant 1R01NS063009. The authors
gratefully acknowledge Erin Clardy for assistance with mouse breeding
and data collection.
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NR 65
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD SEP 1
PY 2013
VL 252
BP 126
EP 135
DI 10.1016/j.bbr.2013.05.060
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 214RN
UT WOS:000324153600017
PM 23747611
ER
PT J
AU Hanks, AN
Dlugolenski, K
Hughes, ZA
Seymour, PA
Majchrzak, MJ
AF Hanks, Ashley N.
Dlugolenski, Keith
Hughes, Zoe A.
Seymour, Patricia A.
Majchrzak, Mark J.
TI Pharmacological disruption of mouse social approach behavior: Relevance
to negative symptoms of schizophrenia
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Social approach; NMDA receptor; Negative symptom; GABA; D-Cycloserine;
Mouse
ID ANIMAL-MODELS; D-CYCLOSERINE; MICE; RECEPTOR; AUTISM; GLUTAMATE; GABA;
HYPOFUNCTION; HYPOTHESIS; PHENOTYPES
AB Social withdrawal is one of several negative symptoms of schizophrenia, all of which are poorly treated by current therapies. One challenge in developing agents with efficacy against negative symptoms is the lack of suitable preclinical models. The social approach test was used as the basis for developing an assay to test emerging therapies for negative symptoms. NMDA antagonists and dopamine agonists have been used extensively to produce or disrupt behaviors thought to be rodent correlates of positive and cognitive symptoms of schizophrenia. The aim of these studies was to determine whether sociability of mice in the 3-chamber social approach test could be disrupted and whether this paradigm could have utility in predicting efficacy against negative symptoms. The criteria for such a model were: a lack of response to antipsychotics and attenuation by agents such as the glycine agonist, D-cycloserine, which has been shown to possess clinical efficacy against negative symptoms. Administration of the NMDA antagonists MK-801, PCP, or ketamine did not disrupt sociability. In contrast, Grin1 hypomorph mice displayed a social deficit which was not reversed by atypical antipsychotics or D-serine. D-Amphetamine disrupted sociability without stimulating locomotor activity and its effect was not reversed by antipsychotics. The GABA(A) inverse agonist, FG-7142, reduced sociability and this was reversed by the GABA(A) antagonist, flumazenil and dcycloserine, but not by clozapine, or the GABA(A) benzodiazepine anxiolytic, alprazolam. Based on our criteria, the GABA(A) model warrants further evaluation to confirm that this paradigm has utility as a preclinical model for predicting efficacy against negative symptoms of schizophrenia. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Hanks, Ashley N.; Dlugolenski, Keith; Hughes, Zoe A.; Seymour, Patricia A.; Majchrzak, Mark J.] Pfizer Global Res, Neurosci Res Unit, Cambridge, MA USA.
RP Hanks, AN (reprint author), Pfizer Global Res, Neurosci Res Unit, 700 Main St, Cambridge, MA USA.
EM Ashley.Hanks@pfizer.com
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NR 36
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD SEP 1
PY 2013
VL 252
BP 405
EP 414
DI 10.1016/j.bbr.2013.06.017
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 214RN
UT WOS:000324153600050
PM 23806621
ER
PT J
AU Hahn, N
Geurten, B
Gurvich, A
Piepenbrock, D
Kastner, A
Zanini, D
Xing, GL
Xie, W
Gopfert, MC
Ehrenreich, H
Heinrich, R
AF Hahn, Nina
Geurten, Bart
Gurvich, Artem
Piepenbrock, David
Kaestner, Anne
Zanini, Damiano
Xing, Guanglin
Xie, Wei
Goepfert, Martin C.
Ehrenreich, Hannelore
Heinrich, Ralf
TI Monogenic heritable autism gene neuroligin impacts Drosophila social
behaviour
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Drosophila melanogaster; Neuroligin; Social behaviour; Acoustic
communication; Behavioural transition; Autism
ID SYNAPSE FORMATION; COURTSHIP SONG; CELL-ADHESION; MOUSE MODEL; NEUREXIN;
COMMUNICATION; MELANOGASTER; MATURATION; TRANSMISSION; INHIBITION
AB Autism spectrum disorders (ASDs) are characterized by deficits in social interactions, language development and repetitive behaviours. Multiple genes involved in the formation, specification and maintenance of synapses have been identified as risk factors for ASDs development. Among these are the neuroligin genes which code for postsynaptic cell adhesion molecules that induce the formation of presynapses, promote their maturation and modulate synaptic functions in both vertebrates and invertebrates. Neuroligin-deficient mice display abnormal social and vocal behaviours that resemble ASDs symptoms.
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C1 [Hahn, Nina; Geurten, Bart; Piepenbrock, David; Zanini, Damiano; Goepfert, Martin C.; Heinrich, Ralf] Univ Gottingen, Inst Zool, Dept Cellular Neurobiol, D-37077 Gottingen, Germany.
[Gurvich, Artem; Kaestner, Anne; Ehrenreich, Hannelore] Max Planck Inst Expt Med, D-37077 Gottingen, Germany.
[Xing, Guanglin; Xie, Wei] Southeast Univ, Inst Life Sci, Key Lab Dev Genes & Human Dis, Nanjing 210009, Peoples R China.
RP Heinrich, R (reprint author), Schwann Schleiden Res Ctr, Dept Cellular Neurobiol, Julia Lermontowa Weg 3, D-37077 Gottingen, Germany.
EM rheinri1@gwdg.de
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NR 55
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD SEP 1
PY 2013
VL 252
BP 450
EP 457
DI 10.1016/j.bbr.2013.06.020
PG 8
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA 214RN
UT WOS:000324153600056
PM 23792025
ER
PT J
AU Wainer, A
Ingersoll, B
AF Wainer, Allison
Ingersoll, Brooke
TI Intervention Fidelity: An Essential Component for Understanding ASD
Parent Training Research and Practice
SO CLINICAL PSYCHOLOGY-SCIENCE AND PRACTICE
LA English
DT Review
DE autism spectrum disorders; fidelity; intervention; parent training
ID AUTISM SPECTRUM DISORDERS; RANDOMIZED CONTROLLED-TRIAL; NATURAL-LANGUAGE
PARADIGM; APPLIED BEHAVIOR ANALYSIS; YOUNG-CHILDREN; TREATMENT
INTEGRITY; IMPLEMENTATION FIDELITY; MENTAL-HEALTH; PRESCHOOL-CHILDREN;
EDUCATION-PROGRAMS
AB Previous research has explored the efficacy and effectiveness of autism spectrum disorder (ASD) parent training interventions. Recent trials of such programs have not replicated earlier compelling outcomes, yet the reasons for the failure of such programs to produce desired effects are unclear. The purpose of the current article is to discuss the role of intervention fidelity in elucidating the relationships between a parent training program, the implementation and sustainability of an intervention, and important child outcomes. The article will discuss the importance of assessing intervention fidelity for the identification and successful use of effective treatment strategies and will propose an integrative conceptual framework for approaching the study and evaluation of intervention fidelity with respect to ASD parent training programs.
C1 [Wainer, Allison; Ingersoll, Brooke] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA.
RP Ingersoll, B (reprint author), Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA.
EM ingers19@msu.edu
RI Ingersoll, Brooke/A-9117-2012
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NR 107
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0969-5893
EI 1468-2850
J9 CLIN PSYCHOL-SCI PR
JI Clin. Psychol.-Sci. Pract.
PD SEP
PY 2013
VL 20
IS 3
BP 335
EP 357
DI 10.1111/cpsp.12045
PG 23
WC Psychology, Clinical
SC Psychology
GA 226BB
UT WOS:000325008100008
ER
PT J
AU Theoharides, TC
AF Theoharides, Theoharis C.
TI Extracellular Mitochondrial ATP, Suramin, and Autism?
SO CLINICAL THERAPEUTICS
LA English
DT Editorial Material
ID RAT MAST-CELLS; SPECTRUM DISORDERS; RELEASE; BRAIN; ACTIVATION; ALLERGY;
MICE; MICROGLIA; LUTEOLIN; DISEASE
C1 [Theoharides, Theoharis C.] Tufts Univ, Sch Med, Dept Biochem, Boston, MA 02111 USA.
[Theoharides, Theoharis C.] Tufts Univ, Sch Med, Dept Internal Med, Boston, MA 02111 USA.
[Theoharides, Theoharis C.] Tufts Univ, Sch Med, Dept Psychiat, Boston, MA 02111 USA.
[Theoharides, Theoharis C.] Tufts Med Ctr, Boston, MA USA.
[Theoharides, Theoharis C.] Theta Biomed Consulting & Dev Co Inc, Brookline, MA USA.
RP Theoharides, TC (reprint author), Tufts Univ, Sch Med, Dept Mol Physiol & Pharmacol, 136 Harrison Ave, Boston, MA 02111 USA.
EM theoharis.theoharides@tufts.edu
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NR 40
TC 2
Z9 2
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0149-2918
J9 CLIN THER
JI Clin. Ther.
PD SEP
PY 2013
VL 35
IS 9
BP 1454
EP 1456
DI 10.1016/j.clinthera.2013.07.419
PG 3
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 231BS
UT WOS:000325388600019
PM 23954092
ER
PT J
AU Anamaria, PC
Ramona, S
Sebastian, P
Jelle, S
Alina, R
Daniel, D
Johan, V
Dirk, L
Bram, V
AF Anamaria, Pop Cristina
Ramona, Simut
Sebastian, Pintea
Jelle, Saldien
Alina, Rusu
Daniel, David
Johan, Vanderfaeillie
Dirk, Lefeber
Bram, Vanderborght
TI CAN THE SOCIAL ROBOT PROBO HELP CHILDREN WITH AUTISM TO IDENTIFY
SITUATION-BASED EMOTIONS? A SERIES OF SINGLE CASE EXPERIMENTS
SO INTERNATIONAL JOURNAL OF HUMANOID ROBOTICS
LA English
DT Article
DE Autism spectrum disorders; situation-based emotions; robot assisted
therapy; emotion recognition; theory of mind
ID FACIAL EXPRESSIONS; ASPERGER-SYNDROME; MIND; INTERVENTION; RECOGNITION;
PEOPLE; SPECTRUM; BEHAVIOR
AB Children with autism spectrum disorders have difficulties in identifying situation-based emotions, which is a fundamental ability for mind reading. Social robots received increased attention as assisting tools for improving the social and emotional skills of children with autism. This study investigates whether the social robot Probo can help children with autism spectrum disorders to enhance their performance in identifying situation-based emotions. Three participants (age between 5 and 6) diagnozed with autism spectrum disorders were included in a single case AB experimental design, with intersubjects replications. The results show that children's performance improved with moderate to large effect sizes in identifying both sadness and happiness. Based on these results, we intend to perform more extensive investigations regarding the effectiveness of robot assisted therapy in improving social-emotional abilities for children with autism spectrum disorders.
C1 [Anamaria, Pop Cristina; Sebastian, Pintea; Alina, Rusu; Daniel, David] Univ Babes Bolyai, Dept Clin Psychol & Psychotherapy, R-3400 Cluj Napoca, Romania.
[Ramona, Simut; Johan, Vanderfaeillie] Vrije Univ Brussel, Clin & Life Span Psychol Dept, Brussels, Belgium.
[Jelle, Saldien] Howest Univ Coll, Ind Design Ctr, Kortrijk, Belgium.
[Daniel, David] Mt Sinai Sch Med, New York, NY 10029 USA.
[Dirk, Lefeber; Bram, Vanderborght] Vrije Univ Brussel, Robot & Multibody Mech Res Grp, Brussels, Belgium.
RP Anamaria, PC (reprint author), Univ Babes Bolyai, Dept Clin Psychol & Psychotherapy, R-3400 Cluj Napoca, Romania.
EM pop.cristina@ubbcluj.ro; ramona.simut@vub.ac.be;
sebastianpintea@psychology.ro; jelle.saldien@gmail.com;
alinasrusu@yahoo.com; danieldavid@psychology.ro;
johan.vanderfaeillie@vub.ac.be; dlefeber@vub.ac.be;
bram.vanderborght@vub.ac.be
FU CNCSIS-Bucharest, Romania [PN-II-IDPCE- 2011-3-0484, VUB-HOA16]
FX The authors wish to thank for the financial support provided from
programs financed by CNCSIS-Bucharest, Romania project PN-II-IDPCE-
2011-3-0484 exploring robot assisted therapy for children with ASD and
VUB-HOA16.
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NR 65
TC 0
Z9 0
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0219-8436
J9 INT J HUM ROBOT
JI Int. J. Humanoid Robot.
PD SEP
PY 2013
VL 10
IS 3
DI 10.1142/S0219843613500254
PG 24
WC Robotics
SC Robotics
GA 230KP
UT WOS:000325338300008
ER
PT J
AU Corrigan, NM
Shaw, DWW
Estes, AM
Richards, TL
Munson, J
Friedman, SD
Dawson, G
Artru, AA
Dager, SR
AF Corrigan, Neva M.
Shaw, Dennis W. W.
Estes, Annette M.
Richards, Todd L.
Munson, Jeff
Friedman, Seth D.
Dawson, Geraldine
Artru, Alan A.
Dager, Stephen R.
TI Atypical Developmental Patterns of Brain Chemistry in Children With
Autism Spectrum Disorder
SO JAMA PSYCHIATRY
LA English
DT Article
ID MAGNETIC-RESONANCE-SPECTROSCOPY; YOUNG-CHILDREN; MITOCHONDRIAL
DYSFUNCTION; MYOINOSITOL LEVELS; MR SPECTROSCOPY; DOWN-SYNDROME; PROTON;
ABNORMALITIES; ADULTS; H-1
AB IMPORTANCE Autism spectrum disorder (ASD) is a neurodevelopmental disorder with symptoms emerging during early childhood. The pathophysiology underlying the disorder remains incompletely understood.
OBJECTIVE To examine cross-sectional and longitudinal patterns of brain chemical concentrations in children with ASD or idiopathic developmental delay (DD) from 3 different age points, beginning early in the clinical course.
DESIGN Proton magnetic resonance spectroscopic imaging data were acquired longitudinally for children with ASD or DD, and primarily cross-sectionally for children with typical development (TD), at 3 to 4, 6 to 7, and 9 to 10 years of age.
SETTING Recruitment, diagnostic assessments, and magnetic resonance imaging were performed at the University of Washington in Seattle.
PARTICIPANTS Seventy-three children (45 with ASD, 14 with DD, and 14 with TD) at 3 to 4 years of age; 69 children (35 with ASD, 14 with DD, and 20 with TD) at 6 to 7 years of age; and 77 children (29 with ASD, 15 with DD, and 33 with TD) at 9 to 10 years of age.
MAIN OUTCOMES AND MEASURES Concentrations of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), myo-inositol (mI), and glutamine plus glutamate (Glx) in cerebral gray matter (GM) and white matter (WM) at 3 to 4, 6 to 7, and 9 to 10 years of age, and calculation of rates of change of these chemicals between 3 and 10 years of age.
RESULTS At 3 to 4 years of age, the ASD group exhibited lower NAA, Cho, and Cr concentrations than did the TD group in both GM and WM, alterations that largely were not observed at 9 to 10 years of age. The DD group exhibited reduced GM and WM NAA concentrations at 3 to 4 years of age; GM NAA concentrations remained reduced at 9 to 10 years of age compared with the TD group. There were distinct differences between the ASD and DD groups in the rates of GM NAA, Cho, and Cr changes between 3 and 10 years of age.
CONCLUSIONS AND RELEVANCE The GM chemical changes between 3 and 10 years of age differentiated the children with ASD from those with DD. Most notably, a dynamic reversal of GM NAA reductions was observed in the children with ASD. By contrast, persistent GM NAA reductions in the children with DD suggest a different, more static, underlying developmental process.
C1 [Corrigan, Neva M.; Shaw, Dennis W. W.; Richards, Todd L.; Dager, Stephen R.] Univ Washington, Dept Radiol, Seattle, WA 98105 USA.
[Estes, Annette M.] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA.
[Munson, Jeff] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Artru, Alan A.] Univ Washington, Dept Anesthesiol, Seattle, WA 98195 USA.
[Dager, Stephen R.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA.
[Shaw, Dennis W. W.; Friedman, Seth D.] Seattle Childrens Hosp, Dept Radiol, Washington, DC USA.
[Dawson, Geraldine] Autism Speaks, New York, NY USA.
[Dawson, Geraldine] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
RP Dager, SR (reprint author), Univ Washington, Dept Radiol, 1100 45th St NE,Ste 555, Seattle, WA 98105 USA.
EM srd@u.washington.edu
FU National Institutes of Health [2P01 HD 35465, 1P50 HD 55782, 1R01 HD
065283]
FX This study was supported by National Institutes of Health grants 2P01 HD
35465, 1P50 HD 55782, and 1R01 HD 065283.
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NR 55
TC 9
Z9 10
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-622X
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD SEP
PY 2013
VL 70
IS 9
BP 964
EP 974
DI 10.1001/jamapsychiatry.2013.1388
PG 11
WC Psychiatry
SC Psychiatry
GA 228JN
UT WOS:000325182200012
PM 23903694
ER
PT J
AU Cardinale, RC
Shih, P
Fishman, I
Ford, LM
Muller, RA
AF Cardinale, Ryan C.
Shih, Patricia
Fishman, Inna
Ford, Leanne M.
Mueller, Ralph-Axel
TI Pervasive Rightward Asymmetry Shifts of Functional Networks in Autism
Spectrum Disorder
SO JAMA PSYCHIATRY
LA English
DT Article
ID INDEPENDENT COMPONENT ANALYSIS; BRAIN ACTIVITY; RIGHT-HEMISPHERE;
CONNECTIVITY; LANGUAGE; CORTEX; DYSFUNCTION; CHILDREN; COMPREHENSION;
PERCEPTION
AB IMPORTANCE Autism spectrum disorder (ASD) is a brain-based pervasive developmental disorder, which-by growing consensus-is associated with abnormal organization of functional networks. Several previous studies of ASD have indicated atypical hemispheric asymmetries for language.
OBJECTIVE To examine the asymmetry of functional networks using a data-driven approach for a comprehensive investigation of hemispheric asymmetry in ASD.
DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study involved 24 children with ASD and 26 matched typically developing children at San Diego State University and the University of California, San Diego. Data from 10 children had to be excluded for excessive motion, resulting in final samples of 20 participants per group.
MAIN OUTCOMES AND MEASURES Asymmetry indices of functional networks identified from independent component analysis of resting-state functional magnetic resonance imaging data.
RESULTS Temporal concatenation independent component analysis, performed separately in each group, showed significant group differences in asymmetry indices for 10 out of 17 functional networks. Without exception, these networks (visual, auditory, motor, executive, language, and attentional) showed atypical rightward asymmetry shifts in the ASD group.
CONCLUSIONS AND RELEVANCE Atypical rightward asymmetry may be a pervasive feature of functional brain organization in ASD, affecting sensorimotor, as well as higher cognitive, domains.
C1 [Cardinale, Ryan C.; Shih, Patricia; Fishman, Inna; Ford, Leanne M.; Mueller, Ralph-Axel] San Diego State Univ, Dept Psychol, Dev Imaging Lab, San Diego, CA 92120 USA.
[Cardinale, Ryan C.] Univ Michigan, Dept Psychol, Ann Arbor, MI USA.
[Shih, Patricia] Brown Univ, Dept Neurosci, Providence, RI 02912 USA.
RP Muller, RA (reprint author), San Diego State Univ, Dept Psychol, 6363 Alvarado Ct,Ste 200, San Diego, CA 92120 USA.
EM rmueller@mail.sdsu.edu
FU National Institutes of Health [R01-MH081023]; [T34-MH65102];
[T32-MH020068]; [K01-MH097972]
FX This study was supported by the National Institutes of Health grant
R01-MH081023, with additional funding from grants T34-MH65102 (Mr
Cardinale), T32-MH020068 (Ms Shih), and K01-MH097972 (Dr Fishman).
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NR 73
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Z9 11
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 2168-622X
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD SEP
PY 2013
VL 70
IS 9
BP 975
EP 982
DI 10.1001/jamapsychiatry.2013.382
PG 8
WC Psychiatry
SC Psychiatry
GA 228JN
UT WOS:000325182200013
PM 23903586
ER
PT J
AU Zuckerman, KE
Mattox, K
Donelan, K
Batbayar, O
Baghaee, A
Bethell, C
AF Zuckerman, Katharine E.
Mattox, Kimber
Donelan, Karen
Batbayar, Oyundari
Baghaee, Anita
Bethell, Christina
TI Pediatrician Identification of Latino Children at Risk for Autism
Spectrum Disorder
SO PEDIATRICS
LA English
DT Article
DE autism spectrum disorder; Hispanic Americans; pediatrics; health care
disparities; child development; developmental disabilities;
developmental screening
ID LIMITED ENGLISH PROFICIENCY; DEFICIT-HYPERACTIVITY DISORDER;
HEALTH-CARE; ETHNIC DISPARITIES; YOUNG-CHILDREN; US CHILDREN;
DEVELOPMENTAL-DISABILITIES; NATIONAL-SURVEY; SERVICES; DIAGNOSIS
AB BACKGROUND AND OBJECTIVES: Latino-white disparities in age at autism spectrum disorder (ASD) diagnosis may be modified by primary care pediatrician (PCP) practices and beliefs. The objectives of this study were to assess ASD and developmental screening practices, attitudes toward ASD identification in Latino children, and barriers to ASD identification for Latino children, in a sample of 267 California PCPs.
METHODS: In mail-based PCP survey, we assessed rates of bilingual general developmental and ASD screening, perceptions of parent ASD knowledge in Latino and white families, reports of difficulty assessing for ASDs in Latino and white children, and perceptions of barriers to early ASD identification for Latinos.
RESULTS: Although 81% of PCPs offered some form of developmental screening, 29% of PCPs offered Spanish ASD screening per American Academy of Pediatrics guidelines, and only 10% offered both Spanish general developmental and Spanish ASD screening per American Academy of Pediatrics guidelines. Most PCPs thought that Latino (English and Spanish primary family language) parents were less knowledgeable about ASDs than white parents. PCPs had more difficulty assessing ASD risk for Latino children with Spanish primary family language than for white children, even when the PCP conducted recommended ASD screening or had > 25% Latino patients. The most frequent barrier to ASD identification in Latinos was access to developmental specialists.
CONCLUSIONS: Multiple factors in the primary care setting may contribute to delayed ASD identification for Latinos. Promoting language-appropriate screening, disseminating culturally appropriate ASD materials to Latino families, improving the specialist workforce, and providing PCP support in screening and referral of Latino children may be important ways to reduce racial and ethnic differences in care.
C1 [Zuckerman, Katharine E.; Mattox, Kimber; Batbayar, Oyundari; Baghaee, Anita; Bethell, Christina] Oregon Hlth & Sci Univ, Child & Adolescent Hlth Measurement Initiat, Portland, OR 97239 USA.
[Zuckerman, Katharine E.; Mattox, Kimber] Oregon Hlth & Sci Univ, Div Gen Pediat, Portland, OR 97239 USA.
[Donelan, Karen] Massachusetts Gen Hosp, Mongan Inst Hlth Policy, Boston, MA 02114 USA.
RP Zuckerman, KE (reprint author), Oregon Hlth & Sci Univ, 707 SW Gaines Rd,Mail Code CDRC P, Portland, OR 97239 USA.
EM zuckerma@ohsu.edu
FU Academic Pediatric Association/Commonwealth Fund Young Investigator
Award; National Institute of Mental Health [1K23MH095828]; National
Institutes of Health (NIH)
FX This project was funded by an Academic Pediatric
Association/Commonwealth Fund Young Investigator Award (principal
investigator, Dr Zuckerman). Dr Zuckerman's effort was partially funded
by grant 1K23MH095828 from the National Institute of Mental Health.
Funded by the National Institutes of Health (NIH).
CR Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
Bethell C, 2004, PEDIATRICS, V113, P1973
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NR 32
TC 10
Z9 10
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2013
VL 132
IS 3
BP 445
EP 453
DI 10.1542/peds.2013-0383
PG 9
WC Pediatrics
SC Pediatrics
GA 226ZX
UT WOS:000325077800039
PM 23958770
ER
PT J
AU Kotte, A
Joshi, G
Fried, R
Uchida, M
Spencer, A
Woodworth, KY
Kenworthy, T
Faraone, SV
Biederman, J
AF Kotte, Amelia
Joshi, Gagan
Fried, Ronna
Uchida, Mai
Spencer, Andrea
Woodworth, K. Yvonne
Kenworthy, Tara
Faraone, Stephen V.
Biederman, Joseph
TI Autistic Traits in Children With and Without ADHD
SO PEDIATRICS
LA English
DT Article
DE ADD; ADHD; attention deficit disorder; attention-deficit/hyperactivity
disorder; AT; autistic traits; autism traits; comorbidity; social
disability
ID DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; COGNITIVE
FLEXIBILITY; MATERNAL INFECTION; ASPERGERS-SYNDROME; BIPOLAR DISORDER;
MOTOR IMPAIRMENT; PERCEPTION DAMP
AB OBJECTIVE: To assess the implications of autistic traits (ATs) in youth with attention-deficit/hyperactivity disorder (ADHD) without a diagnosis of autism.
METHODS: Participants were youth with (n = 242) and without (n = 227) ADHD and controls without ADHD in whom a diagnosis of autism was exclusionary. Assessment included measures of psychiatric, psychosocial, educational, and cognitive functioning. ATs were operationalized by using the withdrawn + social + thought problems T scores from the Child Behavior Checklist.
RESULTS: A positive AT profile was significantly overrepresented among ADHD children versus controls (18% vs 0.87%; P < .001). ADHD children with the AT profile were significantly more impaired than control subjects in psychopathology, interpersonal, school, family, and cognitive domains.
CONCLUSIONS: A substantial minority of ADHD children manifests ATs, and those exhibiting ATs have greater severity of illness and dysfunction.
C1 [Kotte, Amelia; Fried, Ronna; Uchida, Mai; Spencer, Andrea; Woodworth, K. Yvonne; Kenworthy, Tara; Biederman, Joseph] Massachusetts Gen Hosp, Clin Program Pediat Psychopharmacol & Adult ADHD, Boston, MA 02114 USA.
[Kotte, Amelia; Fried, Ronna; Uchida, Mai; Spencer, Andrea; Woodworth, K. Yvonne; Kenworthy, Tara; Biederman, Joseph] Massachusetts Gen Hosp, Res Program Pediat Psychopharmacol & Adult ADHD, Boston, MA 02114 USA.
[Joshi, Gagan; Fried, Ronna; Biederman, Joseph] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
[Joshi, Gagan] Massachusetts Gen Hosp, Alan & Lorraine Bressler Ctr, Boston, MA 02114 USA.
[Faraone, Stephen V.] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA.
[Faraone, Stephen V.] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA.
RP Biederman, J (reprint author), Massachusetts Gen Hosp, Yawkey Ctr Outpatient Care, Clin Program Pediat Psychopharmacol & Adult ADHD, YAW-6A-6900,32 Fruit St, Boston, MA 02114 USA.
EM jbiederman@partners.org
FU National Institute of Mental Health [MH-41314, HD036317, MH050657];
Pediatric Psychopharmacology Research Council Fund; National Institutes
of Health (NIH)
FX The data acquisition from which this analysis was derived was funded by
National Institute of Mental Health grants MH-41314, HD036317, and
MH050657 to Dr Biederman. The manuscript and analysis of the data were
indirectly supported by the Pediatric Psychopharmacology Research
Council Fund. Funded by the National Institutes of Health (NIH).
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NR 58
TC 7
Z9 7
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2013
VL 132
IS 3
BP E612
EP E622
DI 10.1542/peds.2012-3947
PG 11
WC Pediatrics
SC Pediatrics
GA 226ZX
UT WOS:000325077800006
PM 23979086
ER
PT J
AU Sullivan, AL
AF Sullivan, Amanda L.
TI School-Based Autism Identification: Prevalence, Racial Disparities, and
Systemic Correlates
SO SCHOOL PSYCHOLOGY REVIEW
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; ENGLISH-LANGUAGE LEARNERS;
SPECIAL-EDUCATION; SPECTRUM DISORDERS; DIAGNOSTIC SUBSTITUTION;
CHILDREN; DISPROPORTIONALITY; STATES; AGE; US
AB This study examined prevalence and relative risk of school-based autism identification by race, and the relations of each to state characteristics. The sample was drawn from general and special education enrollment data for students ages -21 in 46 states during the 2008-2009 academic year. The results show that 1 in 228 students nationwide was identified with autism for special education eligibility, but there was substantial variability across states, with some states nine times more likely to identify students with autism than others. There were significant differences in prevalence between racial groups at the state level. Hispanic and American Indian/Alaskan Native students were often less likely to be identified with autism relative to White students, whereas Asian/Pacific Islander students were commonly more likely to be identified with autism than White students. Regression analysis indicated systemic predictors of prevalence and minority relative risk varied. Implications for research, practice, and policy are discussed.
C1 [Sullivan, Amanda L.] Univ Minnesota, Sch Psychol, Minneapolis, MN 55455 USA.
RP Sullivan, AL (reprint author), Univ Minnesota, 250 Educ Sci Bldg,56 E River Rd, Minneapolis, MN 55455 USA.
EM asulliva@umn.edu
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NR 71
TC 2
Z9 2
PU NATL ASSOC SCHOOL PSYCHOLOGISTS
PI BETHESDA
PA 4340 EAST WEST HWY, STE 402, BETHESDA, MD 20814 USA
SN 0279-6015
J9 SCHOOL PSYCHOL REV
JI Sch. Psychol. Rev.
PD SEP
PY 2013
VL 42
IS 3
BP 298
EP 316
PG 19
WC Psychology, Educational
SC Psychology
GA 227MW
UT WOS:000325119000004
ER
PT J
AU Carbone, PS
AF Carbone, Paul S.
TI Moving From Research to Practice in the Primary Care of Children With
Autism Spectrum Disorders
SO ACADEMIC PEDIATRICS
LA English
DT Article
DE autism; autism spectrum disorders; primary care
ID PERVASIVE DEVELOPMENTAL DISORDERS; YOUNG-CHILDREN; HIGH-RISK;
GASTROINTESTINAL PROBLEMS; BEHAVIORAL INTERVENTION; INTELLECTUAL
DISABILITY; ALTERNATIVE MEDICINE; IDENTIFYING INFANTS;
CLINICAL-ASSESSMENT; MODIFIED CHECKLIST
AB Autism spectrum disorders (ASD), once thought rare, are now commonly encountered in clinical practice. Academic pediatricians may be expected to teach medical students and pediatric residents about ASD, but most likely received limited exposure to ASD during their training. In recent years, research that informs the clinical guidance provided to pediatricians regarding surveillance, screening, and ongoing management of children with ASD has accelerated. By 24 months of age, children with ASD exhibit delays across multiple domains of development, yet the diagnosis is frequently made much later. Careful developmental surveillance lowers the age of identification of children with ASD. Several screening tools appropriate for use in primary care settings can aid in early identification. Improved surveillance and screening is of benefit because early intensive behavioral intervention has the potential to improve the developmental trajectory of children with ASD. Providing appropriate medical care for children with ASD improves both child and family outcomes. Recent research regarding sleep disturbances, gastrointestinal problems, and epilepsy in children with ASD has led to clinical pathways to evaluate and address these issues within the context of primary care. By being aware of and disseminating these research findings, academic pediatricians can help future and current clinicians improve the care of children with ASD.
C1 [Carbone, Paul S.] Univ Utah, Dept Pediat, Hlth Sci Ctr, Salt Lake City, UT USA.
RP Carbone, PS (reprint author), 295 Chipeta Way, Salt Lake City, UT 84108 USA.
EM paul.carbone@hsc.utah.edu
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NR 125
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD SEP-OCT
PY 2013
VL 13
IS 5
BP 390
EP 399
PG 10
WC Pediatrics
SC Pediatrics
GA 223WQ
UT WOS:000324843600002
PM 24011743
ER
PT J
AU Oakley, G
Howitt, C
Garwood, R
Durack, AR
AF Oakley, Grace
Howitt, Christine
Garwood, Rebekah
Durack, Annie-Rose
TI Becoming multimodal authors: Pre-service teachers' interventions to
support young children with autism
SO AUSTRALASIAN JOURNAL OF EARLY CHILDHOOD
LA English
DT Article
ID SPECTRUM DISORDERS; READING MOTIVATION; ASPERGER-SYNDROME; STUDENTS;
NEEDS; TECHNOLOGY; INDIVIDUALS; CLASSROOMS; ENGAGEMENT; LANGUAGE
AB THE PURPOSE OF THIS ARTICLE is to describe two case studies of classroom-based teaching interventions, conducted by final-year pre-service teachers, which were successful in assisting young children with autism engage in and learn literacy through the use of Information and Communication Technologies (ICTs). The 10-day interventions were carried out as part of a two-year Master of Teaching course at an Australian university, and were designed to identify specific learning needs in young children, and then implement targeted interventions. The two cases described here show how ICTs were successfully used to create multimodal texts to support the literacy learning and engagement of young children with autism. The first case involved an intervention that employed two iPad apps-which were not intended specifically for children with autism-to support the literacy learning and engagement of a five-year-old. The second case involved the use of Microsoft PowerPoint on a laptop to develop multimodal non-fiction texts to improve an eight-year-old's attitude to, and engagement with, reading. Each intervention was found to be effective in improving the participating child's literacy achievement and engagement. Each used multisensory and student-centred approaches that acknowledged the children's strengths and interests, with ICTs being used to transform teaching and learning tasks. This article illustrates the successful drawing together of pre-service teachers' technological, pedagogical and content knowledge (TPACK), as well as their knowledge of the children concerned, to devise evidence-based interventions using ICTs to assist young children with autism to engage in, and learn, literacy.
C1 [Oakley, Grace; Howitt, Christine; Garwood, Rebekah; Durack, Annie-Rose] Univ Western Australia, Nedlands, WA 6009, Australia.
RP Oakley, G (reprint author), Univ Western Australia, Nedlands, WA 6009, Australia.
RI Howitt, Christine/H-5076-2014
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Australian Institute for Teaching and School Leadership (AITSL), 2012, AUSTR PROF STAND TEA
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Willis C., 2009, YOUNG CHILDREN, P81
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NR 58
TC 0
Z9 0
PU EARLY CHILDHOOD AUSTRALIA INC
PI WATSON
PA PO BOX 7105, WATSON, ACT 2602, AUSTRALIA
SN 0312-5033
J9 AUST J EARLY CHILD
JI Aust. J. Early Child.
PD SEP
PY 2013
VL 38
IS 3
BP 86
EP 96
PG 11
WC Education & Educational Research
SC Education & Educational Research
GA 219QI
UT WOS:000324522800011
ER
PT J
AU FitzGerald, LM
Kumar, A
Boyle, EA
Zhang, YZ
McIntosh, LM
Kolb, S
Stott-Miller, M
Smith, T
Karyadi, DM
Ostrander, EA
Hsu, L
Shendure, J
Stanford, JL
AF FitzGerald, Liesel M.
Kumar, Akash
Boyle, Evan A.
Zhang, Yuzheng
McIntosh, Laura M.
Kolb, Suzanne
Stott-Miller, Marni
Smith, Tiffany
Karyadi, Danielle M.
Ostrander, Elaine A.
Hsu, Li
Shendure, Jay
Stanford, Janet L.
TI Germline Missense Variants in the BTNL2 Gene Are Associated with
Prostate Cancer Susceptibility
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; BRCA2 GENE; MUTATIONS; HOXB13; RISK; LOCI;
SEQUENCE; IDENTIFICATION; INFLAMMATION; SARCOIDOSIS
AB Background: Rare, inherited mutations account for 5% to 10% of all prostate cancer cases. However, to date, few causative mutations have been identified.
Methods: To identify rare mutations for prostate cancer, we conducted whole-exome sequencing (WES) in multiple kindreds (n = 91) from 19 hereditary prostate cancer (HPC) families characterized by aggressive or early-onset phenotypes. Candidate variants (n = 130) identified through family- and bioinformatics-based filtering of WES data were then genotyped in an independent set of 270 HPC families (n = 819 prostate cancer cases; n = 496 unaffected relatives) for replication. Two variants with supportive evidence were subsequently genotyped in a population-based case-control study (n = 1,155 incident prostate cancer cases; n = 1,060 age-matched controls) for further confirmation. All participants were men of European ancestry.
Results: The strongest evidence was for two germline missense variants in the butyrophilin-like 2 (BTNL2) gene (rs41441651, p. Asp336Asn and rs28362675, p.Gly454Cys) that segregated with affection status in two of the WES families. In the independent set of 270 HPC families, 1.5% (rs41441651; P = 0.0032) and 1.2% (rs28362675; P = 0.0070) of affected men, but no unaffected men, carried a variant. Both variants were associated with elevated prostate cancer risk in the population-based study (rs41441651: OR, 2.7; 95% CI, 1.27-5.87; P = 0.010; rs28362675: OR, 2.5; 95% CI, 1.16-5.46; P = 0.019).
Conclusions: Results indicate that rare BTNL2 variants play a role in susceptibility to both familial and sporadic prostate cancer.
Impact: Results implicate BTNL2 as a novel prostate cancer susceptibility gene. (C) 2013 AACR.
C1 [FitzGerald, Liesel M.; Zhang, Yuzheng; McIntosh, Laura M.; Kolb, Suzanne; Stott-Miller, Marni; Hsu, Li; Stanford, Janet L.] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
[Kumar, Akash; Boyle, Evan A.; Shendure, Jay] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA USA.
[Stanford, Janet L.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
[Smith, Tiffany; Karyadi, Danielle M.; Ostrander, Elaine A.] NHGRI, NIH, Canc Genet Branch, Bethesda, MD 20892 USA.
RP Stanford, JL (reprint author), Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N,POB 19024,M4-B874, Seattle, WA 98109 USA.
EM jstanfor@fhcrc.org
FU U.S. National Cancer Institute, NIH [RO1 CA080122, P50 CA097186]; Fred
Hutchinson Cancer Research Center; Prostate Cancer Foundation; NIH
[HHSN268200782096C]; NHLBI [RC2 HL-103010, RC2 HL-102923, RC2 HL-102924,
RC2 HL-102925, RC2 HL-102926]; Achievement Award for College Scientists
Fellowship; Lowell Milken Prostate Cancer Foundation Young Investigator
Award; Intramural Program of the National Human Genome Research
Institute; Prostate Cancer Foundation Creativity Award
FX This work was supported by grants from the U.S. National Cancer
Institute, NIH (grant numbers RO1 CA080122 and P50 CA097186 to J.L.
Stanford); with additional support from the Fred Hutchinson Cancer
Research Center; and the Prostate Cancer Foundation. Sequencing services
were provided by the Center for Inherited Disease Research, which is
funded through a contract from NIH to The Johns Hopkins University
(contract no. HHSN268200782096C). Funding for GO ESP was provided by
NHLBI grants RC2 HL-103010 (HeartGO), RC2 HL-102923 (LungGO), and RC2
HL-102924 (WHISP). The exome sequencing was conducted through NHLBI
grants RC2 HL-102925 (BroadGO) and RC2 HL-102926 (SeattleGO). A. Kumar
is supported by an Achievement Award for College Scientists Fellowship;
J. Shendure is supported by The Lowell Milken Prostate Cancer Foundation
Young Investigator Award; E. A. Ostrander is supported by the Intramural
Program of the National Human Genome Research Institute; J. L. Stanford
is supported by a Prostate Cancer Foundation Creativity Award.
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NR 47
TC 4
Z9 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD SEP
PY 2013
VL 22
IS 9
BP 1520
EP 1528
DI 10.1158/1055-9965.EPI-13-0345
PG 9
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 221QV
UT WOS:000324674500005
PM 23833122
ER
PT J
AU Roux, G
Sofronoff, K
Sanders, M
AF Roux, Gemma
Sofronoff, Kate
Sanders, Matthew
TI A Randomized Controlled Trial of Group Stepping Stones Triple P: A
Mixed-Disability Trial
SO FAMILY PROCESS
LA English
DT Article
DE Parenting; Disability; Stepping Stones Triple P
ID POSITIVE PARENTING PROGRAM; INTELLECTUAL DISABILITY; CHILDREN;
INTERVENTION; ADJUSTMENT; STRESS
AB Stepping Stones Triple P (SSTP) is a parenting program designed for families of a child with a disability. The current study involved a randomized controlled trial of Group Stepping Stones Triple P (GSSTP) for a mixed-disability group. Participants were 52 families of children diagnosed with an Autism Spectrum Disorder, Down syndrome, Cerebral Palsy, or an intellectual disability. The results demonstrated significant improvements in parent-reported child behavior, parenting styles, parental satisfaction, and conflict about parenting. Results among participants were similar despite children's differing impairments. The intervention effect was maintained at 6-month follow-up. The results indicate that GSSTP is a promising intervention for a mixed-disability group. Limitations of the study, along with areas for future research, are also discussed.
C1 [Roux, Gemma; Sofronoff, Kate; Sanders, Matthew] Univ Queensland, Sch Psychol, St Lucia, Qld, Australia.
RP Sofronoff, K (reprint author), Univ Queensland, Sch Psychol, St Lucia, Qld Ed 4072, Australia.
EM kate@psy.uq.edu.au
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NR 29
TC 6
Z9 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-7370
J9 FAM PROCESS
JI Fam. Process
PD SEP
PY 2013
VL 52
IS 3
BP 411
EP 424
DI 10.1111/famp.12016
PG 14
WC Psychology, Clinical; Family Studies
SC Psychology; Family Studies
GA 218CX
UT WOS:000324411300006
PM 24033239
ER
PT J
AU Yoo, HJ
Cho, IH
Park, M
Yang, SY
Kim, SA
AF Yoo, Hee Jeong
Cho, In Hee
Park, Mira
Yang, So Young
Kim, Soon Ae
TI Association of the Catechol-o-Methyltransferase Gene Polymorphisms with
Korean Autism Spectrum Disorders
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Autism Spectrum Disorders (ASD); Polymorphisms, Single Nucleotide
(SNPs); Catechol-O-Methyltransferase Gene (COMT); Family-Based
Association Study
ID PROMOTER REGION; ENZYME-ACTIVITY; COMT; SCHIZOPHRENIA; PHENOTYPES; BRAIN
AB This study evaluated the family-based genetic association between autism spectrum disorders (ASDs) and 5 single-nucleotide polymorphisms (SNPs) in the catechol-o-methyltransferase gene (COMT), which was found among 151 Korean ASDs family trios (dominant model Z = 2.598, P = 0.009, P-FDR = 0.045). We found a statistically significant allele transmission or association in terms of the rs6269 SNP in the ASDs trios. Moreover, in the haplotype analysis, the haplotypes with rs6269 demonstrated significant evidence of an association with ASDs (additive model rs6269-rs4818-rs4680-rs769224 haplotype P = 0.004, P-FDR = 0.040). Thus, an association may exist between the variants of the COMT gene and the occurrence of ASDs in Koreans.
C1 [Yoo, Hee Jeong] Seoul Natl Univ, Bundang Hosp, Dept Psychiat, Songnam, South Korea.
[Cho, In Hee] Gachon Univ, Gil Med Ctr, Dept Psychiat, Inchon, South Korea.
[Park, Mira] Eulji Univ, Sch Med, Dept Prevent Med, Taejon 301746, South Korea.
[Yang, So Young] Chungnam Natl Univ, Coll Pharm, Dept Pharmacol, Taejon, South Korea.
[Kim, Soon Ae] Eulji Univ, Sch Med, Dept Pharmacol, Taejon 301746, South Korea.
RP Kim, SA (reprint author), Eulji Univ, Sch Med, Dept Pharmacol, 77 Gyeryong Ro 771 Beon Gil, Taejon 301746, South Korea.
EM sakim@eulji.ac.kr
FU National Research Foundation of Korea (NRF); Korea government (MEST)
[2010-0007583]; Ministry of Health & Welfare, Republic of Korea
[A120029]; Ministry of Education, Science and Technology [2011-0004376]
FX This work was supported by the National Research Foundation of Korea
(NRF) grant funded by the Korea government (MEST) (2010-0007583). This
work was also supported by the Korea Healthcare Technology R&D project,
Ministry of Health & Welfare, Republic of Korea (grant number A120029).
Mira Park was supported by Basic Science Research Program through the
National Research Foundation of Korea (NRF) funded by the Ministry of
Education, Science and Technology (2011-0004376).
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NR 15
TC 3
Z9 3
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
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PY 2013
VL 28
IS 9
BP 1403
EP 1406
DI 10.3346/jkms.2013.28.9.1403
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 219YG
UT WOS:000324547000024
PM 24015051
ER
PT J
AU Botbol, M
Cabon, P
Kermarrec, S
Tordjman, S
AF Botbol, Michel
Cabon, Philippe
Kermarrec, Solenn
Tordjman, Sylvie
TI Biological and psychological rhythms: An integrative approach to rhythm
disturbances in autistic disorder
SO JOURNAL OF PHYSIOLOGY-PARIS
LA English
DT Article
DE Biological rhythms; Circadian rhythms; Psychic rhythms; Melatonin cycle;
Infantile autism
ID SLEEP-WAKE RHYTHM; SHIFT WORK; CIRCADIAN-RHYTHM; JET-LAG;
MORNINGNESS-EVENINGNESS; SPECTRUM DISORDERS; GANGLION-CELLS; BRIGHT
LIGHT; MELATONIN; CHILDREN
AB Biological rhythms are crucial phenomena that are perfect examples of the adaptation of organisms to their environment. A considerable amount of work has described different types of biological rhythms (from circadian to ultradian), individual differences in their patterns and the complexity of their regulation. In particular, the regulation and maturation of the sleep-wake cycle have been thoroughly studied. Its desynchronization, both endogenous and exogenous, is now well understood, as are its consequences for cognitive impairments and health problems. From a completely different perspective, psychoanalysts have shown a growing interest in the rhythms of psychic life. This interest extends beyond the original focus of psychoanalysis on dreams and the sleep-wake cycle, incorporating central theoretical and practical psychoanalytic issues related to the core functioning of the psychic life: the rhythmic structures of drive dynamics, intersubjective developmental processes and psychic containment functions. Psychopathological and biological approaches to the study of infantile autism reveal the importance of specific biological and psychological rhythmic disturbances in this disorder. Considering data and hypotheses from both perspectives, this paper proposes an integrative approach to the study of these rhythmic disturbances and offers an etiopathogenic hypothesis based on this integrative approach. (c) 2013 Elsevier Ltd. All rights reserved.
C1 [Botbol, Michel; Tordjman, Sylvie] Univ Paris 05, Lab Psychol Percept, Paris, France.
[Botbol, Michel; Tordjman, Sylvie] CNRS, UMR 8158, Paris, France.
[Botbol, Michel] Univ Bretagne Occidentale, CHU Brest, Serv Hosp Univ Psychiat Enfant & Adolescent, Brest, France.
[Cabon, Philippe] Univ Paris, Inst Psychol, Lab Adaptat, F-75252 Paris, France.
[Kermarrec, Solenn; Tordjman, Sylvie] Univ Rennes 1, CHGR, Pole Hosp Univ Psychiat Enfant & Adolescent, F-35014 Rennes, France.
RP Botbol, M (reprint author), CHU Brest, Hop Bohars, Serv Univ Psychiat Infanto Juvenile, F-29820 Bohars, France.
EM botbolmichel@orange.fr
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NR 148
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0928-4257
J9 J PHYSIOL-PARIS
JI J. Physiol.-Paris
PD SEP
PY 2013
VL 107
IS 4
SI SI
BP 298
EP 309
DI 10.1016/j.jphysparis.2013.03.009
PG 12
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA 223DA
UT WOS:000324783100009
PM 23542543
ER
PT J
AU Frank, GKW
AF Frank, Guido K. W.
TI An 11-Year-Old Boy With Asperger's Disorder Presenting With Aggression
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Editorial Material
ID PERVASIVE DEVELOPMENTAL DISORDERS; AUTISM SPECTRUM DISORDER;
HIGH-FUNCTIONING AUTISM; CHILDREN; FAMILIES; ANXIETY
C1 Univ Colorado, Sch Med, Dept Psychiat, Boulder, CO 80309 USA.
[Frank, Guido K. W.] Univ Colorado, Sch Med, Dept Neurosci, Boulder, CO 80309 USA.
RP Frank, GKW (reprint author), Univ Colorado, Sch Med, Dept Psychiat, Anschutz Med Campus, Boulder, CO 80309 USA.
EM guido.frank@ucdenver.edu
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NR 16
TC 0
Z9 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD SEP
PY 2013
VL 170
IS 9
BP 963
EP 966
DI 10.1176/appi.ajp.2013.12121611
PG 4
WC Psychiatry
SC Psychiatry
GA 212VK
UT WOS:000324010700008
PM 24030610
ER
PT J
AU Gershon, ES
Alliey-Rodriguez, N
AF Gershon, Elliot S.
Alliey-Rodriguez, Ney
TI New Ethical Issues for Genetic Counseling in Common Mental Disorders
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Review
ID COPY-NUMBER VARIATION; AUTISM SPECTRUM DISORDERS; DE-NOVO CNVS; HUMAN
GENOME; HUMAN-DISEASE; SCHIZOPHRENIA; REARRANGEMENTS; MUTATIONS;
VARIANTS; IMPACT
AB Objective: Recent genetic findings of high-impact genetic variants in bipolar disorder, schizophrenia, and autism spectrum disorder (ASD) must lead to profound changes in genetic and family counseling. The authors present risk calculations, discuss the ethical implications of these findings, and outline the changes now required in the risk counseling process.
Method: The authors use data from recent mega-analyses and reviews of common and rare risk variants in bipolar disorder, schizophrenia, and ASD to calculate risks of illness based on genetic marker tests. They then consider new ethical issues in mental disorders presented by these risks, including within-family conflicts over genetic testing; effects of genetic discoveries on stigma, abortion, preimplantation procedures, and population screening for susceptibility; and genetic tests as a factor in marital choice.
Results: New structural mutations (de novo copy number variants [CNVs], which are chromosomal microdeletions and microduplications) are present in 4%-7% of patients with bipolar disorder, schizophrenia, or ASD and can occur almost anywhere in the genome. For a person with a de novo CNV, the absolute risk of bipolar disorder, schizophrenia, or ASD is 14%, much higher than the population risk. Rare CNVs have also been identified that are generally not new mutations but constitute very high-effect risk factors, ranging up to 82%.
Conclusions: A substantial minority of patients with bipolar disorder, schizophrenia, and ASD have high-impact detectable genetic events. This greatly changes psychiatric genetic counseling for these patients and families. A psychotherapeutic approach may be needed as a routine part of risk counseling, particularly for resolution of ethical issues and for within-family stigma and conflicts over genetic test results.
C1 [Gershon, Elliot S.; Alliey-Rodriguez, Ney] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA.
RP Gershon, ES (reprint author), Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA.
EM egershon@yoda.bsd.uchicago.edu
FU NIH [1R01MH094483-01A1]; NARSAD; Eklund family; Geraldi Norton
Foundation
FX Supported by NIH grant 1R01MH094483-01A1 to Dr. Gershon and a NARSAD
Young Investigator Award to Dr. Alliey-Rodriguez; by the Eklund family;
and by the Geraldi Norton Foundation.
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NR 44
TC 9
Z9 9
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD SEP
PY 2013
VL 170
IS 9
BP 968
EP 976
DI 10.1176/appi.ajp.2013.12121558
PG 9
WC Psychiatry
SC Psychiatry
GA 212VK
UT WOS:000324010700010
PM 23897273
ER
PT J
AU Saenz, J
Alexander, GM
AF Saenz, Janet
Alexander, Gerianne M.
TI Postnatal testosterone levels and disorder relevant behavior in the
second year of life
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Postnatal androgens; Testosterone; Social-emotional problems; Sex
differences
ID CONGENITAL ADRENAL-HYPERPLASIA; 4TH DIGIT RATIO; MALE-BRAIN THEORY;
PRENATAL PHTHALATE EXPOSURE; EMOTIONAL ASSESSMENT BITSEA; FINGER LENGTH
RATIO; FETAL TESTOSTERONE; DEVELOPMENTAL PSYCHOPATHOLOGY; TESTICULAR
ACTIVITY; PRESCHOOL-CHILDREN
AB The objective of the current study was to investigate the relationship between testosterone collected at 3-4 months of age and sex-linked disorder-relevant behaviors in the second year of life. Eighty-four children participated at 3-4 (when salivary testosterone levels were obtained and second to fourth digit ratios were measured) and 18-24 months of age (when behavioral ratings of aggression and verbal ability were coded from two 8-min play sessions). Parents also completed the Brief Infant-Toddler Social and Emotional Assessment, and the four subscales (Internalizing, Externalizing, Dysregulation, and Autism Spectrum Disorder) were used to indicate child specific problems. Greater postnatal testosterone levels in early infancy were predictive of more male-typical behaviors in the second year of life (i.e., more autism spectrum behaviors, less time vocalizing, and more Internalizing Problems). These results support the hypothesis that early infancy may be another critical period for the development of gender-linked behavior. Published by Elsevier B.V.
C1 [Saenz, Janet; Alexander, Gerianne M.] Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA.
RP Saenz, J (reprint author), Texas A&M Univ, Dept Psychol, MS 4235, College Stn, TX 77843 USA.
EM jsaenz@neo.tamu.edu
FU National Science Foundation [BCS-0618411]
FX This work was supported by National Science Foundation Grant BCS-0618411
(GMA). We thank Dr. Teresa Wilcox and members of the Infant Cognition
Lab for assistance in the recruitment of babies and their families.
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-0511
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD SEP
PY 2013
VL 94
IS 1
BP 152
EP 159
DI 10.1016/j.biopsycho.2013.05.011
PG 8
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
Experimental
SC Psychology; Behavioral Sciences
GA 205YD
UT WOS:000323480000018
PM 23727253
ER
PT J
AU Ahmadlou, M
Gharib, M
Hemmati, S
Vameghi, R
Sajedi, F
AF Ahmadlou, Mehran
Gharib, Masoud
Hemmati, Sahel
Vameghi, Roshanak
Sajedi, Firoozeh
TI Disrupted small-world brain network in children with Down Syndrome
SO CLINICAL NEUROPHYSIOLOGY
LA English
DT Article
DE Down Syndrome; Electroencephalogram; Functional brain connectivity;
Small-Worldness; Visibility Graph Similarity
ID GRAPH-THEORETICAL ANALYSIS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
FUZZY SYNCHRONIZATION LIKELIHOOD; MAJOR DEPRESSIVE DISORDER; AUTISM
SPECTRUM DISORDER; WORKING-MEMORY TASK; FUNCTIONAL CONNECTIVITY;
ALZHEIMERS-DISEASE; THETA-OSCILLATIONS; VISIBILITY GRAPH
AB Objective: To explore how the global organization or topology of the functional brain connectivity (FBC) is affected in Down Syndrome (DS).
Methods: As the brain is a highly complex network including numerous nonlinearly interacted neuronal areas, the FBCs of typically developing (TD) children and DS patients were computed using a nonlinear synchronization method. Then the differences in global organization of the obtained FBCs of the two groups were analyzed, in all electroencephalogram (EEG) frequency bands, in the framework of Small-Worldness Network (a network with optimum balance between segregation and integration of information).
Results: The topology of the functional connectivity of DS patients is disrupted in the whole brain in alpha and theta bands, and especially in the left intra-hemispheric brain networks in upper alpha band.
Conclusions: The global organization of the DS brain does not resemble a Small-World network, but it works as a random network.
Significance: It is the first study on global organization of the FBC in DS. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Ahmadlou, Mehran] Netherlands Inst Neurosci, Amsterdam, Netherlands.
[Ahmadlou, Mehran; Sajedi, Firoozeh] Dynam Brain Res Inst, Tehran, Iran.
[Gharib, Masoud; Hemmati, Sahel; Vameghi, Roshanak; Sajedi, Firoozeh] Univ Social Welf & Rehabil Sci, Pediat Neurorehabil Res Ctr, Tehran, Iran.
RP Gharib, M (reprint author), Univ Social Welf & Rehabil Sci, Pediat Neurorehabil Res Ctr, Tehran, Iran.
EM pediatricnrc@yahoo.com
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NR 88
TC 1
Z9 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 1388-2457
J9 CLIN NEUROPHYSIOL
JI Clin. Neurophysiol.
PD SEP
PY 2013
VL 124
IS 9
BP 1755
EP 1764
DI 10.1016/j.clinph.2013.03.004
PG 10
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 213AV
UT WOS:000324026200009
PM 23583023
ER
PT J
AU Gearing, RE
Schwalbe, CSJ
Lee, R
Hoagwood, KE
AF Gearing, Robin E.
Schwalbe, Craig S. J.
Lee, RaeHyuck
Hoagwood, Kimberly E.
TI THE EFFECTIVENESS OF BOOSTER SESSIONS IN CBT TREATMENT FOR CHILD AND
ADOLESCENT MOOD AND ANXIETY DISORDERS
SO DEPRESSION AND ANXIETY
LA English
DT Article
DE CBT; cognitive behavior therapy; child; adolescent; anxiety; anxiety
disorders; mood disorders; empirical supported treatments; treatment;
booster session
ID COGNITIVE-BEHAVIORAL THERAPY; RANDOMIZED CONTROLLED-TRIAL;
OBSESSIVE-COMPULSIVE DISORDER; AUTISM SPECTRUM DISORDERS; FOLLOW-UP;
CLINICAL-TRIAL; DEPRESSIVE SYMPTOMS; SOCIAL PHOBIA; FUTURE-DIRECTIONS;
MAJOR DEPRESSION
AB Background To investigate the effects of booster sessions in cognitive behavioral therapy (CBT) for children and adolescents with mood or anxiety disorders, whereas controlling for youth demographics (e.g., gender, age), primary diagnosis, and intervention characteristics (e.g., treatment modality, number of sessions).
Methods Electronic databases were searched for CBT interventions for youth with mood and anxiety disorders. Fifty-three (k=53) studies investigating 1,937 youth met criteria for inclusion. Booster sessions were examined using two case-controlled effect sizes: pre-post and pre-follow-up (6 months) effect sizes and employing weighted least squares (WLSs) regressions.
Results Meta-analyses found pre-post studies with booster sessions had a larger effect size r=.58 (k=15; 95% CI=0.52-0.65; P<.01) than those without booster sessions r=.45 (k=38; 95% CI=0.41-0.49; P<.001). In the WLS regression analyses, controlling for demographic factors, primary diagnosis, and intervention characteristics, studies with booster sessions showed larger pre-post effect sizes than those without booster sessions (B=0.13, P<.10). Similarly, pre-follow-up studies with booster sessions showed a larger effect size r=.64 (k=10; 95% CI=0.57-0.70; P<.10) than those without booster sessions r=.48 (k=20; 95% CI=0.42-0.53; P<.01). Also, in the WLS regression analyses, pre-follow-up studies showed larger effect sizes than those without booster sessions (B=0.08, P<.01) after accounting for all control variables.
Conclusions Result suggests that CBT interventions with booster sessions are more effective and the effect is more sustainable for youth managing mood or anxiety disorders than CBT interventions without booster sessions.
C1 [Gearing, Robin E.; Schwalbe, Craig S. J.; Lee, RaeHyuck] Columbia Univ, New York, NY 10027 USA.
[Hoagwood, Kimberly E.] NYU, Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA.
RP Gearing, RE (reprint author), Columbia Univ, 1255 Amsterdam Ave, New York, NY 10027 USA.
EM rg2372@columbia.edu
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NR 94
TC 3
Z9 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD SEP
PY 2013
VL 30
IS 9
BP 800
EP 808
DI 10.1002/da.22118
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
SC Psychology; Psychiatry
GA 210II
UT WOS:000323824300003
PM 23596102
ER
PT J
AU Ousley, OY
Smearman, E
Fernandez-Carriba, S
Rockers, KA
Coleman, K
Walker, EF
Cubells, JF
AF Ousley, O. Y.
Smearman, E.
Fernandez-Carriba, S.
Rockers, K. A.
Coleman, K.
Walker, E. F.
Cubells, J. F.
TI Axis I psychiatric diagnoses in adolescents and young adults with 22q11
deletion syndrome
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE Schizophrenia and psychosis; Autism; Affective disorders; Anxiety
disorders; Genetics
ID CARDIO-FACIAL SYNDROME; AUTISTIC SPECTRUM DISORDERS; INTERRATER
RELIABILITY; PREDICTIVE-VALIDITY; PRODROMAL SYNDROMES; DE-NOVO;
SCHIZOPHRENIA; SYMPTOMS; INTERVIEW; ONSET
AB Background: 22q11.2 deletion syndrome (22q11DS) associates with schizophrenia spectrum disorders (SSDs), autism spectrum disorders (ASDs), and other psychiatric disorders, but co-occurrence of diagnoses are not well described.
Methods: We evaluated the co-occurrence of SSDs, ASDs and other axis I psychiatric diagnoses in 31 adolescents and adults with 22q11DS, assessing ASDs using either stringent Collaborative Program for Excellence in Autism (ASD-CPEA) criteria, or less stringent DSM-IV criteria alone (ASD-DSM-IV).
Results: Ten (32%) individuals met criteria for an SSD, five (16%) for ASD-CPEA, and five others (16%) for ASD-DSM-IV. Of those with ASD-CPEA, one (20%) met SSD criteria. Of those with ASD-DSM-IV, four (80%) met SSD criteria. Depressive disorders (8 individuals; 26%) and anxiety disorders (7; 23%) sometimes co-occurred with SSDs and ASDs. SSDs, ASDs, and anxiety occurred predominantly among males and depression predominantly among females.
Conclusions: Individuals with 22q11DS can manifest SSDs in the presence or absence of ASDs and other axis I diagnoses. The results suggest that standard clinical care should include childhood screening for ASDs, and later periodic screening for all axis I diagnoses. (C) 2013 Elsevier Masson SAS. All rights reserved.
C1 [Ousley, O. Y.; Fernandez-Carriba, S.; Walker, E. F.; Cubells, J. F.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Emory Autism Ctr, Atlanta, GA 30322 USA.
[Smearman, E.] Emory Univ, Sch Med, Med Scientist Training Program, Atlanta, GA 30322 USA.
[Smearman, E.] Emory Univ, Rollins Sch Publ Hlth, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA.
[Fernandez-Carriba, S.] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA.
[Rockers, K. A.; Coleman, K.; Cubells, J. F.] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA.
[Coleman, K.] Childrens Healthcare Atlanta, Atlanta, GA 30322 USA.
[Coleman, K.] Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
[Walker, E. F.] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA.
RP Ousley, OY (reprint author), Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Emory Autism Ctr, 1551 Shoup Court, Atlanta, GA 30322 USA.
EM oousley@emory.edu
FU Autism Foundation of Georgia; NIH Medical Scientist Training grant [T32
GM008169]; Burroughs Wellcome Fund [008188]; Robert W. Woodruff Fund;
NARSAD
FX Robert W. Woodruff Fund (J.F. Cubells, O.Y. Ousley), NARSAD (O.Y.
Ousley), the Autism Foundation of Georgia (J.F. Cubells), NIH Medical
Scientist Training grant T32 GM008169 (E. Smearman), and the Burroughs
Wellcome Fund (Grant number 008188; E. Smearman). A. Nichole Evans and
Danielle Tidwell provided research assistance. Portions of these data
were presented at the 8th Biennial 22q11.2 Deletion Syndrome Meeting,
Orlando, Florida, July 8, 2012.
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NR 39
TC 0
Z9 1
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD SEP
PY 2013
VL 28
IS 7
BP 417
EP 422
DI 10.1016/j.eurpsy.2013.06.002
PG 6
WC Psychiatry
SC Psychiatry
GA 215UD
UT WOS:000324235300005
PM 23916466
ER
PT J
AU Bay, B
Mortensen, EL
Kesmodel, US
AF Bay, Bjorn
Mortensen, Erik Lykke
Kesmodel, Ulrik Schioler
TI Assisted reproduction and child neurodevelopmental outcomes: a
systematic review
SO FERTILITY AND STERILITY
LA English
DT Review
DE Infertility; assisted reproduction; child development; neurodevelopment;
mental disorders
ID IN-VITRO FERTILIZATION; INTRACYTOPLASMIC SPERM INJECTION; SPONTANEOUSLY
CONCEIVED CHILDREN; AUTISM SPECTRUM DISORDERS; PSYCHOLOGICAL FOLLOW-UP;
GRONINGEN ART COHORT; PSYCHOMOTOR DEVELOPMENT; PSYCHOSOCIAL ADJUSTMENT;
NATURAL CONCEPTION; MOTOR DEVELOPMENT
AB Objective: To systematically review the existing literature on neurodevelopmental outcomes in children born after medically assisted reproduction compared with those of children born after spontaneous conception.
Design: Systematic review.
Setting: Not applicable.
Patient(s): Children born after medically assisted reproduction vs. reference groups of spontaneously conceived children.
Intervention(s): Data were reviewed from worldwide published articles, without restrictions as to publication year or language. A total of 80 studies included between 31 and 2,446,044 children.
Main Outcome Measure(s): Child neurodevelopmental outcomes categorized as cognitive, behavioral, emotional or psychomotor development, or diagnoses of mental disorders.
Result(s): For infants, studies on psychomotor development showed no deficits, but few investigated cognitive or behavioral development. Studies on toddlers generally reported normal cognitive, behavioral, socio-emotional, and psychomotor development. For children in middle childhood, development seems comparable in children born after assisted reproduction and controls, although fewer studies have been conducted with follow-up to this age. Very few studies have assessed neurodevelopmental outcomes among teens, and the results are inconclusive. Studies investigating the risk of diagnoses of mental disorders are generally large, with long follow-up, but the results are inconsistent.
Conclusion(s): It may tentatively be concluded that the neurodevelopment of children born after fertility treatment is overall comparable to that in children born after spontaneous conception. (C) 2013 by American Society for Reproductive Medicine.
C1 [Bay, Bjorn] Aarhus Univ, Epidemiol Sect, Sch Publ Hlth, Aarhus, Denmark.
[Bay, Bjorn; Kesmodel, Ulrik Schioler] Aarhus Univ, Inst Clin Med, Fertil Clin, Dept Obstet & Gynecol, Aarhus, Denmark.
[Mortensen, Erik Lykke] Univ Copenhagen, Inst Publ Hlth, Copenhagen, Denmark.
[Mortensen, Erik Lykke] Univ Copenhagen, Ctr Hlth Aging, Copenhagen, Denmark.
RP Bay, B (reprint author), Aarhus Univ Hosp Denmark, Dept Obstet & Gynecol, Brendstrupgaardsvej 100, DK-8200 Aarhus, Denmark.
EM bjornbay@me.com
FU sperm bank Cryos International Denmark ApS; Aarhus University;
Augustinus Foundation, Denmark [11-1553]
FX B.B. has received salary for consultancy from the sperm bank Cryos
International Denmark ApS regarding medical advice and selection and
screening of semen donors. U.S.K. is a lecturer for Merck Serono. E.L.M.
has nothing to disclose.This project was initiated by the authors and
was funded by a fellowship granted by Aarhus University and partially
funded by The Augustinus Foundation, Denmark (grant no. 11-1553). The
sources of funding had no role in study design, data collection,
analysis, interpretation, writing the report, or in the decision to
submit the article for publication.
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NR 112
TC 5
Z9 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD SEP
PY 2013
VL 100
IS 3
BP 844
EP 853
DI 10.1016/j.fertnstert.2013.05.034
PG 10
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 215UA
UT WOS:000324234900051
PM 23810272
ER
PT J
AU Dittwald, P
Gambin, T
Szafranski, P
Li, J
Amato, S
Divon, MY
Rojas, LXR
Elton, LE
Scott, DA
Schaaf, CP
Torres-Martinez, W
Stevens, AK
Rosenfeld, JA
Agadi, S
Francis, D
Kang, SHL
Breman, A
Lalani, SR
Bacino, CA
Bi, WM
Milosavljevic, A
Beaudet, AL
Patel, A
Shaw, CA
Lupski, JR
Gambin, A
Cheung, SW
Stankiewicz, P
AF Dittwald, Piotr
Gambin, Tomasz
Szafranski, Przemyslaw
Li, Jian
Amato, Stephen
Divon, Michael Y.
Rodriguez Rojas, Lisa Ximena
Elton, Lindsay E.
Scott, Daryl A.
Schaaf, Christian P.
Torres-Martinez, Wilfredo
Stevens, Abby K.
Rosenfeld, Jill A.
Agadi, Satish
Francis, David
Kang, Sung-Hae L.
Breman, Amy
Lalani, Seema R.
Bacino, Carlos A.
Bi, Weimin
Milosavljevic, Aleksandar
Beaudet, Arthur L.
Patel, Ankita
Shaw, Chad A.
Lupski, James R.
Gambin, Anna
Cheung, Sau Wai
Stankiewicz, Pawel
TI NAHR-mediated copy-number variants in a clinical population: Mechanistic
insights into both genomic disorders and Mendelizing traits
SO GENOME RESEARCH
LA English
DT Article
ID 17Q21.31 MICRODELETION SYNDROME; SEGMENTAL DUPLICATIONS; HOMOLOGOUS
RECOMBINATION; DEVELOPMENTAL DELAY; RECIPROCAL DUPLICATIONS; RECURRENT
DELETIONS; DNA REARRANGEMENTS; DPY19L2 DELETION; GENE; DISEASE
AB We delineated and analyzed directly oriented paralogous low-copy repeats (DP-LCRs) in the most recent version of the human haploid reference genome. The computationally defined DP-LCRs were cross-referenced with our chromosomal microarray analysis (CMA) database of 25,144 patients subjected to genome-wide assays. This computationally guided approach to the empirically derived large data set allowed us to investigate genomic rearrangement relative frequencies and identify new loci for recurrent nonallelic homologous recombination (NAHR)-mediated copy-number variants (CNVs). The most commonly observed recurrent CNVs were NPHP1 duplications (233), CHRNA7 duplications (175), and 22q11.21 deletions (DiGeorge/velocardiofacial syndrome, 166). In the similar to 25% of CMA cases for which parental studies were available, we identified 190 de novo recurrent CNVs. In this group, the most frequently observed events were deletions of 22q11.21 (48), 16p11.2 (autism, 34), and 7q11.23 (Williams-Beuren syndrome, 11). Several features of DP-LCRs, including length, distance between NAHR substrate elements, DNA sequence identity (fraction matching), GC content, and concentration of the homologous recombination (HR) hot spot motif 5'-CCNCCNTNNCCNC-3', correlate with the frequencies of the recurrent CNVs events. Four novel adjacent DP-LCR-flanked and NAHR-prone regions, involving 2q12.2q13, were elucidated in association with novel genomic disorders. Our study quantitates genome architectural features responsible for NAHR-mediated genomic instability and further elucidates the role of NAHR in human disease.
C1 [Dittwald, Piotr; Gambin, Tomasz; Szafranski, Przemyslaw; Li, Jian; Scott, Daryl A.; Schaaf, Christian P.; Kang, Sung-Hae L.; Breman, Amy; Lalani, Seema R.; Bacino, Carlos A.; Bi, Weimin; Milosavljevic, Aleksandar; Beaudet, Arthur L.; Patel, Ankita; Shaw, Chad A.; Lupski, James R.; Cheung, Sau Wai; Stankiewicz, Pawel] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Dittwald, Piotr; Gambin, Anna] Univ Warsaw, Inst Informat, PL-02097 Warsaw, Poland.
[Dittwald, Piotr] Univ Warsaw, Coll Interfac Individual Studies Math & Nat Sci, PL-02089 Warsaw, Poland.
[Gambin, Tomasz] Warsaw Univ Technol, Inst Comp Sci, PL-02665 Warsaw, Poland.
[Amato, Stephen] Phoenix Childrens Hosp, Phoenix, AZ 85006 USA.
[Divon, Michael Y.] Lenox Hill Hosp, New York, NY 10065 USA.
[Rodriguez Rojas, Lisa Ximena] Fdn Clin Valle del Lili, Cali 76001000, Colombia.
[Elton, Lindsay E.] Pediat Specialty Serv, Austin, TX 78723 USA.
[Scott, Daryl A.] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA.
[Torres-Martinez, Wilfredo; Stevens, Abby K.] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.
[Rosenfeld, Jill A.] PerkinElmer Inc, Signature Genom Labs, Spokane, WA 99207 USA.
[Agadi, Satish] Baylor Coll Med, Dept Pediat & Neurol, Houston, TX 77030 USA.
[Francis, David] Murdoch Childrens Res Inst, Dept Cytogenet, Victorian Clin Genet Serv, Parkville, Vic 3052, Australia.
[Lupski, James R.] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
[Lupski, James R.] Texas Childrens Hosp, Houston, TX 77030 USA.
[Gambin, Anna] Polish Acad Sci, Mossakowski Med Res Ctr, PL-02106 Warsaw, Poland.
RP Stankiewicz, P (reprint author), Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
EM pawels@bcm.tmc.edu
FU Intellectual and Developmental Disabilities Research Center (IDDRC) [P30
HD024064]; National Institute of Neurological Disorders and Stroke
(National Institutes of Health) [R01 NS058529]; Polish National Science
Center [2011/01/B/NZ2/00864]; EU through the European Social Fund
[UDA-POKL.04.01.01-00-072/09-00]; Doris Duke Clinical Scientist
Development Award; Foundation for Polish Science
FX We thank Dr. Pengfei Liu, Ian M. Campbell, Amber N. Pursley, and Kristen
T. Maliszewski for helpful discussions. This work was supported in part
by the Intellectual and Developmental Disabilities Research Center
(IDDRC) (grant number P30 HD024064) and the National Institute of
Neurological Disorders and Stroke (National Institutes of Health) (grant
number R01 NS058529) to J.R.L., the Polish National Science Center
(grant number 2011/01/B/NZ2/00864) to A.G. and P.D., the EU through the
European Social Fund (grant number UDA-POKL.04.01.01-00-072/09-00) to
P.D. C.P.S. is a recipient of a Doris Duke Clinical Scientist
Development Award. P.D. is supported by a START fellowship from the
Foundation for Polish Science.
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NR 65
TC 19
Z9 21
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 1088-9051
J9 GENOME RES
JI Genome Res.
PD SEP
PY 2013
VL 23
IS 9
BP 1395
EP 1409
DI 10.1101/gr.152454.112
PG 15
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Genetics & Heredity
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Genetics & Heredity
GA 213SJ
UT WOS:000324080000004
PM 23657883
ER
PT J
AU Cochran, DM
Fallon, D
Hill, M
Frazier, JA
AF Cochran, David M.
Fallon, Daniel
Hill, Michael
Frazier, Jean A.
TI The Role of Oxytocin in Psychiatric Disorders: A Review of Biological
and Therapeutic Research Findings
SO HARVARD REVIEW OF PSYCHIATRY
LA English
DT Review
DE anxiety; anxiety disorders; autism; humans; mood disorders; oxytocin;
schizophrenia
ID OBSESSIVE-COMPULSIVE DISORDER; SOCIAL ANXIETY DISORDER; RECEPTOR GENE
OXTR; BORDERLINE PERSONALITY-DISORDER; INTRANASAL OXYTOCIN; PLASMA
OXYTOCIN; CEREBROSPINAL-FLUID; MAJOR DEPRESSION;
ELECTROCONVULSIVE-THERAPY; PARAVENTRICULAR NUCLEUS
AB Learning Objectives: After participating in this educational activity, the physician should be better able to
1. Identify the biological role of oxytocin in forming attachments.
2. Evaluate the relationship between various neuropsychiatric disorders and oxytocin.
3. Identify clinical implications of using oxytocin to treat various neuropsychiatric disorders.
Oxytocin is a peptide hormone integral in parturition, milk letdown, and maternal behaviors that has been demonstrated in animal studies to be important in the formation of pair bonds and in social behaviors. This hormone is increasingly recognized as an important regulator of human social behaviors, including social decision making, evaluating and responding to social stimuli, mediating social interactions, and forming social memories. In addition, oxytocin is intricately involved in a broad array of neuropsychiatric functions and may be a common factor important in multiple psychiatric disorders such as autism, schizophrenia, and mood and anxiety disorders. This review article examines the extant literature on the evidence for oxytocin dysfunction in a variety of psychiatric disorders and highlights the need for further research to understand the complex role of the oxytocin system in psychiatric disease and thus pave the way for developing new therapeutic modalities. Articles were selected that involved human participants with various psychiatric disorders and that either compared oxytocin biology to healthy controls or examined the effects of exogenous oxytocin administration.
C1 [Cochran, David M.; Hill, Michael; Frazier, Jean A.] Univ Massachusetts, Sch Med, Dept Psychiat, Div Child & Adolescent Psychiat, Amherst, MA 01003 USA.
[Fallon, Daniel] Univ S Florida, Dept Psychiat, Tampa, FL 33620 USA.
RP Cochran, DM (reprint author), Univ Massachusetts, Sch Med, Div Child Psychiat, 55 Lake Ave N, Worcester, MA 01655 USA.
EM David.Cochran@umassmemorial.org
FU GlaxoSmithKline; Pfizer Inc.; Roche Pharmaceuticals; Seaside
Therapeutics
FX Dr. Frazier receives research grant support from GlaxoSmithKline, Pfizer
Inc., Roche Pharmaceuticals, and Seaside Therapeutics.
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NR 139
TC 7
Z9 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1067-3229
J9 HARVARD REV PSYCHIAT
JI Harv. Rev. Psychiatr.
PD SEP-OCT
PY 2013
VL 21
IS 5
BP 219
EP 247
DI 10.1097/HRP.0b013e3182a75b7d
PG 29
WC Psychiatry
SC Psychiatry
GA 219HK
UT WOS:000324496700001
PM 24651556
ER
PT J
AU Ravet, J
AF Ravet, Jackie
TI Delving deeper into the black box: formative assessment, inclusion and
learners on the autism spectrum
SO INTERNATIONAL JOURNAL OF INCLUSIVE EDUCATION
LA English
DT Article
DE formative assessment; autism; inclusion; inferential process;
communication
ID CHILDREN; DISORDER; VIEWS
AB This paper explores the implementation of formative assessment through the autism lens' in order to analyse why the process can be exclusionary for some learners on the autism spectrum. The central thesis of the paper is that, where teachers have no understanding of the autism learning style, they are likely to revert to a normative, majoritarian' construction of learning. Two problems may flow from this. First, majoritarian assumptions about learning could dominate the inferential process that is the foundation stone of formative assessment. This could lead teachers to mis-read what is going on inside the heads of learners on the autism spectrum, and cause them to make partial and inaccurate inferences about their learning. Second, majoritarian assumptions may also inform the interactive process that underpins formative assessment. Social interaction can be challenging for learners on the autism spectrum and can limit or exclude their participation unless sensitive modifications are made to the social and communication environment. The case is, therefore, made for teacher awareness of a minoritarian' perspective that foregrounds knowledge and understanding of the autism learning style. Arguably, this knowledge and understanding could enable teachers to adapt the formative assessment process so that it is more effective and inclusive for this group of learners.
C1 Univ Aberdeen, Sch Educ, Kings Coll, Aberdeen AB24 5UA, Scotland.
RP Ravet, J (reprint author), Univ Aberdeen, Sch Educ, Kings Coll, MacRobert Bldg, Aberdeen AB24 5UA, Scotland.
EM j.ravet@abdn.ac.uk
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NR 54
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1360-3116
J9 INT J INCLUSIVE EDUC
JI Int. J. Incl. Educ.
PD SEP 1
PY 2013
VL 17
IS 9
BP 948
EP 964
DI 10.1080/13603116.2012.719552
PG 17
WC Education & Educational Research
SC Education & Educational Research
GA 211OL
UT WOS:000323918500003
ER
PT J
AU Howell, KB
Kornberg, AJ
Harvey, AS
Ryan, MM
Mackay, MT
Freeman, JL
Casero, MVR
Collins, KJ
Hayman, M
Mohamed, A
Ware, TL
Clark, D
Bruno, DL
Burgess, T
Slater, H
McGillivray, G
Leventer, RJ
AF Howell, Katherine B.
Kornberg, Andrew J.
Harvey, A. Simon
Ryan, Monique M.
Mackay, Mark T.
Freeman, Jeremy L.
Casero, M. Victoria Rodriguez
Collins, Kevin J.
Hayman, Michael
Mohamed, Ahmad
Ware, Tyson L.
Clark, Damian
Bruno, Damien L.
Burgess, Trent
Slater, Howard
McGillivray, George
Leventer, Richard J.
TI High resolution chromosomal microarray in undiagnosed neurological
disorders
SO JOURNAL OF PAEDIATRICS AND CHILD HEALTH
LA English
DT Article
DE chromosomal microarray; copy number variant; long continuous stretch
homozygosity; single nucleotide polymorphism microarray
ID COPY NUMBER VARIANTS; BRAIN MALFORMATIONS; CHILD; CLASSIFICATION
AB Aim Despite advances in medical investigation, many children with neurological conditions remain without a diagnosis, although a genetic aetiology is often suspected. Chromosomal microarray (CMA) screens for copy number variants (CNVs) and long continuous stretches of homozygosity (LCSH) and may further enhance diagnostic yield. Although recent studies have identified pathogenic CNVs in intellectual disability, autism and epilepsy, the utility of CMA testing in a broader cohort of children with neurologic disorders has not been reported.
Methods Two hundred fifteen patients with neurological conditions of unknown aetiology were seen over a 6-month period and were prospectively tested by CMA using high-resolution single nucleotide polymorphism (SNP) microarrays (Illumina HumanCytoSNP-12 v2.1 or Affymetrix 2.7M).
Results Thirty of 215 (14%) patients tested had an abnormal CMA. Twenty-nine had CNVs (13%) and one (0.5%) a clinically significant stretch of homozygosity. Twenty (9.3%) had a CMA finding considered to be pathogenic or involved in susceptibility to the condition of interest, and 10 (4.7%) had findings of unknown significance. Their phenotypes included infantile spasms and other epilepsies, neuromuscular conditions, ataxia, movement disorders, microcephaly and malformations of cortical development. At least one third of patients did not meet national funding criteria for CMA at the time of presentation.
Conclusions CMA detected clinically significant abnormalities in a broad range of neurologic phenotypes of unknown aetiology. This test should be considered a first-tier investigation of children with neurologic disorders in whom the initial clinical assessment does not indicate a likely aetiology, especially those with severe epilepsies and neurologically abnormal neonates.
C1 [Howell, Katherine B.; Kornberg, Andrew J.; Harvey, A. Simon; Ryan, Monique M.; Mackay, Mark T.; Freeman, Jeremy L.; Casero, M. Victoria Rodriguez; Collins, Kevin J.; Hayman, Michael; Mohamed, Ahmad; Ware, Tyson L.; Clark, Damian; Leventer, Richard J.] Royal Childrens Hosp, Dept Neurol, Melbourne, Vic, Australia.
[Harvey, A. Simon; Ryan, Monique M.; Mackay, Mark T.; Freeman, Jeremy L.; Bruno, Damien L.; Slater, Howard; Leventer, Richard J.] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia.
[Harvey, A. Simon; Ryan, Monique M.; Bruno, Damien L.; Slater, Howard; McGillivray, George; Leventer, Richard J.] Murdoch Childrens Res Inst, Melbourne, Vic, Australia.
[Bruno, Damien L.; Burgess, Trent; Slater, Howard; McGillivray, George] Victorian Clin Genet Serv, Melbourne, Vic, Australia.
RP Leventer, RJ (reprint author), Royal Childrens Hosp Melbourne, Dept Neurol, Flemington Rd, Parkville, Vic 3052, Australia.
EM richard.leventer@rch.org.au
RI Bruno, Damien/C-3665-2013
FU Victorian Government
FX The authors would like to thank Mr Ralph Oertel for assistance with
database searches. This work has been supported by the Victorian
Government's Operational Infrastructure Support Program.
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NR 23
TC 4
Z9 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1034-4810
J9 J PAEDIATR CHILD H
JI J. Paediatr. Child Health
PD SEP
PY 2013
VL 49
IS 9
BP 716
EP 724
DI 10.1111/jpc.12256
PG 9
WC Pediatrics
SC Pediatrics
GA 212YI
UT WOS:000324018500027
PM 23731025
ER
PT J
AU Bourke-Taylor, H
Pallant, JF
Law, M
Howie, L
AF Bourke-Taylor, Helen
Pallant, Julie F.
Law, Mary
Howie, Linsey
TI Relationships between sleep disruptions, health and care
responsibilities among mothers of school-aged children with disabilities
SO JOURNAL OF PAEDIATRICS AND CHILD HEALTH
LA English
DT Article
DE caring; developmental; general paediatrics
ID QUALITY-OF-LIFE; BEHAVIOR PROBLEMS; PARENTING STRESS; CEREBRAL-PALSY;
MENTAL-HEALTH; DEVELOPMENTAL-DISABILITIES; MATERNAL DEPRESSION; AUTISM;
METAANALYSIS; DISORDERS
AB Aim Sleep problems are more common among children with disabilities. Mothers are likely to provide night-time care. Mothers of children with disabilities are known to experience high levels of stress and mental health issues compared with other mothers. Relationships between a child's sleep problems, and chronic maternal sleep interruption and subjective health have not been researched.
Method Cross-sectional mail-out survey with follow-up phone call was used. Instruments included the Short Form 36 version 2 and instruments that measured maternal, child and sleep characteristics. Descriptive statistics examined characteristics of participants and correlation, and Kruskal-Wallis test was used to determine important maternal and child characteristics around sleep issues.
Results All mothers (n = 152) cared for a school-aged child with a developmental disability including autism spectrum disorder (n = 94) and cerebral palsy (n = 29). Nearly half (49%) of the mothers were awoken more than 4 nights/week. Three distinct sleep groups were identified: no sleep interruption; sleep interruption once/night, 4nights/week; and more frequent interruption. Mothers experiencing the most sleep interruptions reported significantly poorer health on six Short Form 36 version 2 dimensions. Night-time caregiving was associated with higher child care needs rather than children's diagnoses. Mothers who experienced more sleep interruption also participated less in health-promoting activities (active leisure, time with socially supportive others) during the day.
Conclusion This study identifies a group of mothers with chronic sleep interruption and demonstrates related poor maternal subjective health and lower participation in health activities that may service to support maternal health. Mothers with children with the highest daytime care needs also experienced high night-time care responsibilities. Changes to service provision are recommended to identify mothers in need of additional supports and services.
C1 [Bourke-Taylor, Helen] Monash Univ, Sch Primary Hlth Care, Dept Occupat Therapy, Fac Med Nursing & Hlth Sci, Frankston, Vic 3199, Australia.
[Pallant, Julie F.] Univ Melbourne, Rural Hlth Acad Ctr, Shepparton, Vic, Australia.
[Howie, Linsey] La Trobe Univ, Fac Hlth Sci, Sch Occupat Therapy, Melbourne, Vic, Australia.
[Law, Mary] McMaster Univ, CanChild Ctr Childhood Disabil Res, Hamilton, ON, Canada.
RP Bourke-Taylor, H (reprint author), Monash Univ, Sch Primary Hlth Care, Dept Occupat Therapy, Fac Med Nursing & Hlth Sci, Peninsula Campus,POB 527, Frankston, Vic 3199, Australia.
EM Helen.Bourke-Taylor@monash.edu
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Wright Marilyn, 2006, Phys Occup Ther Pediatr, V26, P55, DOI 10.1300/J006v26n03_05
NR 41
TC 8
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1034-4810
J9 J PAEDIATR CHILD H
JI J. Paediatr. Child Health
PD SEP
PY 2013
VL 49
IS 9
BP 775
EP 782
DI 10.1111/jpc.12254
PG 8
WC Pediatrics
SC Pediatrics
GA 212YI
UT WOS:000324018500035
PM 23745960
ER
PT J
AU Whitehouse, AJO
AF Whitehouse, Andrew J. O.
TI Complementary and alternative medicine for autism spectrum disorders:
Rationale, safety and efficacy
SO JOURNAL OF PAEDIATRICS AND CHILD HEALTH
LA English
DT Review
DE alternative medicine; autism; autism spectrum disorder; complementary
medicine; efficacy
ID PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED-TRIAL; HYPERBARIC-OXYGEN
THERAPY; CASEIN-FREE DIET; DOUBLE-BLIND; MELATONIN TREATMENT; PORCINE
SECRETIN; CLINICAL-TRIAL; SLEEP PROBLEMS; GLUTEN-FREE
AB Complementary and alternative medicine is widely used for children with autism spectrum disorder, despite uncertainty regarding efficacy. This review describes complementary and alternative practices commonly used among this population, the rationale for the use of each practice, as well as the side-effect profile and evidence for efficacy. The existing evidence base indicates that melatonin can be recommended as a treatment for sleeping disturbances associated with autism spectrum disorder, while secretin can be rejected as an efficacious treatment for broader autistic symptoms. There is insufficient evidence to draw conclusions on the efficacy of modified diets, hyperbaric oxygen therapy, immune therapy, and vitamin and fatty acid supplementation. There is a clear need for methodologically rigorous studies to provide evidence-based guidance to families and clinicians regarding complementary and alternative practices for individuals with autism spectrum disorders.
C1 [Whitehouse, Andrew J. O.] Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Perth, WA 6009, Australia.
[Whitehouse, Andrew J. O.] Univ Western Australia, Neurocognit Dev Unit, Sch Psychol, Perth, WA 6009, Australia.
RP Whitehouse, AJO (reprint author), Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, 100 Roberts Rd, Subiaco, WA 6872, Australia.
EM awhitehouse@ichr.uwa.edu.au
FU National Health and Medical Research Council [1004065]
FX The author is supported by a Career Development Fellowship from the
National Health and Medical Research Council (No. 1004065).
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NR 50
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1034-4810
J9 J PAEDIATR CHILD H
JI J. Paediatr. Child Health
PD SEP
PY 2013
VL 49
IS 9
BP E438
EP E442
DI 10.1111/jpc.12242
PG 5
WC Pediatrics
SC Pediatrics
GA 212YI
UT WOS:000324018500016
PM 23682728
ER
PT J
AU Peeters, B
Noens, I
Philips, EM
Kuppens, S
Benninga, MA
AF Peeters, Babette
Noens, Ilse
Philips, Elise M.
Kuppens, Sofie
Benninga, Marc A.
TI Autism Spectrum Disorders in Children with Functional Defecation
Disorders
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; GASTROINTESTINAL SYMPTOMS; CHILDHOOD
CONSTIPATION; EPIDEMIOLOGY; POPULATION; PREVALENCE
AB Objective To prospectively assess the prevalence of autism spectrum disorder (ASD) symptoms in children presenting with functional defecation disorders.
Study design Children (age 4-12 years) with functional constipation or functional non-retentive fecal incontinence according to the Rome III criteria referred to a specialized outpatient clinic were included. Parents completed 2 validated ASD screening questionnaires about their child; the Social Responsiveness Scale (SRS) and the Social Communication Questionnaire-Lifetime (SCQ-L). A total SRS score of >= 51 is a strong indicator for the presence of ASD. On the SCQ-L, a score of >= 15 is suggestive for ASD.
Results In total, 242 patients (130 males, median age 7.9 years) were included. Of these, 91% were diagnosed with functional constipation and 9% with functional non-retentive fecal incontinence. Thirteen children (5.4%) had previously been diagnosed with ASD. Twenty-six children (11%) had both SRS and SCQ-L scores at or above cutoff points, strongly suggestive for the presence of ASD. Solely high SRS were present in 42 children (17%), whereas two children (1%) only had high SCQ-L scores. Altogether, 29% had ASD symptoms, indicated by SRS and/or SCQ-L scores at or above the cutoff values. These children were older than children without ASD symptoms and presented with a longer duration of symptoms.
Conclusions A substantial number of children (29%) presenting with a functional defecation disorder at a tertiary hospital has concomitant ASD symptoms. Clinicians should be aware of ASD symptoms in children with functional defecation disorders.
C1 [Peeters, Babette; Philips, Elise M.; Benninga, Marc A.] Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, Dept Pediat Gastroenterol & Nutr, NL-1105 AZ Amsterdam, Netherlands.
[Noens, Ilse] Katholieke Univ Leuven, Parenting & Special Educ Res Unit, Louvain, Belgium.
[Noens, Ilse] Katholieke Univ Leuven, Leuven Autism Res, Louvain, Belgium.
[Kuppens, Sofie] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
RP Peeters, B (reprint author), Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, Dept Pediat Gastroenterol & Nutr, Room C2-312,Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM b.peeters@amc.uva.nl
FU institutional departmental funds
FX Supported by institutional departmental funds. The authors declare no
conflicts of interest.
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NR 32
TC 6
Z9 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
J9 J PEDIATR-US
JI J. Pediatr.
PD SEP
PY 2013
VL 163
IS 3
BP 873
EP 878
DI 10.1016/j.jpeds.2013.02.028
PG 6
WC Pediatrics
SC Pediatrics
GA 212LQ
UT WOS:000323985300052
PM 23522863
ER
PT J
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Loring, DW
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LA English
DT Editorial Material
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C1 [Meador, Kimford J.; Loring, David W.] Emory Univ, Atlanta, GA 30322 USA.
RP Meador, KJ (reprint author), Emory Univ, Atlanta, GA 30322 USA.
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TC 1
Z9 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
J9 J PEDIATR-US
JI J. Pediatr.
PD SEP
PY 2013
VL 163
IS 3
BP 924
EP 924
PG 1
WC Pediatrics
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GA 212LQ
UT WOS:000323985300070
PM 23973243
ER
PT J
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van Doorenmalen, A
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van Doorenmalen, Anniek
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SO JOURNAL OF PHONETICS
LA English
DT Article
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MOVEMENTS; EMOTIONS; MODALITY; AUTISM; ADULTS
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C1 [Swerts, Marc; van Doorenmalen, Anniek; Verhoofstad, Lynn] Tilburg Univ, Sch Humanities, Tilburg Ctr Cognit & Commun TiCC, Dept Commun & Informat Sci, NL-5000 LE Tilburg, Netherlands.
RP Swerts, M (reprint author), Tilburg Univ, Sch Humanities, Tilburg Ctr Cognit & Commun TiCC, Dept Commun & Informat Sci, POB 90153, NL-5000 LE Tilburg, Netherlands.
EM m.g.j.swerts@uvt.nl
RI Swerts, Marc/C-8855-2013
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TC 0
Z9 0
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0095-4470
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BP 359
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GA 214SC
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SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Editorial Material
ID SPECTRUM DISORDERS
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RP Howlin, P (reprint author), Kings Coll London, De Cresigny Pk, London SE5 8AF, England.
EM patricia.howlin@kcl.ac.uk
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NR 16
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD SEP
PY 2013
VL 52
IS 9
BP 897
EP 899
DI 10.1016/j.jaac.2013.06.010
PG 3
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 212TS
UT WOS:000324006300004
PM 23972691
ER
PT J
AU Roux, AM
Shattuck, PT
Cooper, BP
Anderson, KA
Wagner, M
Narendorf, SC
AF Roux, Anne M.
Shattuck, Paul T.
Cooper, Benjamin P.
Anderson, Kristy A.
Wagner, Mary
Narendorf, Sarah C.
TI Postsecondary Employment Experiences Among Young Adults With an Autism
Spectrum Disorder
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE adolescent; autism; employment; outcomes; young adult
ID PREVALENCE; TRANSITION; YOUTH; EDUCATION; CHILDREN; SERVICE; SCHOOL
AB Objective: We examined postsecondary employment experiences of young adults with an autism spectrum disorder (ASD) and compared these outcomes with those of young adults with different disabilities. Method: Data were from Wave 5 of the National Longitudinal Transition Study-2 (NLTS2), a nationally representative survey of young adults who had received special education services during high school. We examined the prevalence of ever having had, and currently having, a paid job at 21 to 25 years of age. We analyzed rates of full-time employment, wages earned, number of jobs held since high school, and job types. Results: Approximately one-half (53.4%) of young adults with an ASD had ever worked for pay outside the home since leaving high school, the lowest rate among disability groups. Young adults with an ASD earned an average of $8.10 per hour, significantly lower than average wages for young adults in the comparison groups, and held jobs that clustered within fewer occupational types. Odds of ever having had a paid job were higher for those who were older, from higher-income households, and with better conversational abilities or functional skills. Conclusions: Findings of worse employment outcomes for young adults with an ASD suggest that this population is experiencing particular difficulty in successfully transitioning into employment. Research is needed to determine strategies for improving outcomes as these young adults transition into adulthood.
C1 [Roux, Anne M.; Shattuck, Paul T.; Cooper, Benjamin P.] Washington Univ, George Warren Brown Sch Social Work, St Louis, MO 63130 USA.
[Anderson, Kristy A.] Univ Wisconsin Madison, Waisman Ctr, Madison, WI USA.
[Narendorf, Sarah C.] Univ Houston, Grad Coll Social Work, Houston, TX 77004 USA.
RP Roux, AM (reprint author), Washington Univ, 1 Brookings Dr,Campus Box 1196, St Louis, MO 63130 USA.
EM aroux@wustl.edu
FU Emch Foundation; Autism Speaks; National Institute-of Mental Health
(NIMH) [R01 MH086489]
FX This work was supported by funding to Dr. Shattuck from the Emch
Foundation, Autism Speaks, and the National Institute-of Mental Health
(NIMH; R01 MH086489). Its contents are solely the responsibility of the
authors and do not represent the views of NIMH or other funders.
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American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 39
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD SEP
PY 2013
VL 52
IS 9
BP 931
EP 939
DI 10.1016/j.jaac.2013.05.019
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 212TS
UT WOS:000324006300008
PM 23972695
ER
PT J
AU Ghanizadeh, A
Berk, M
Farrashbandi, H
Shoushtari, AA
Villagonzalo, KA
AF Ghanizadeh, Ahmad
Berk, Michael
Farrashbandi, Hassan
Shoushtari, Ali Alavi
Villagonzalo, Kristi-Ann
TI Targeting the mitochondrial electron transport chain in autism, a
systematic review and synthesis of a novel therapeutic approach
SO MITOCHONDRION
LA English
DT Review
DE Mitochondria; Autism; Treatment; Energy; Oxidative stress; Etiology
ID METHYLENE-BLUE; RESPIRATORY-CHAIN; COMPLEX-I; N-ACETYLCYSTEINE; BIPOLAR
DISORDER; OXIDATIVE STRESS; SUPEROXIDE-PRODUCTION; SPECTRUM DISORDERS;
ENERGY-METABOLISM; DISEASE
AB Autism is a complex developmental disorder with an unknown etiology and without any curative treatment. The mitochondrial electron transfer chains play a major role in the production of ATP, and the generation and management of reactive oxidative stress (ROS). This paper is a systematic review of the role-of the mitochondrial electron transport chain in autism, and a consequent hypothesis for treating autism is synthesized. An electronic search with pre-specified inclusion criteria was conducted in order to retrieve all the published articles about the mitochondrial electron transport chain in autism. The two databases of PUBMED and Google Scholar were searched.
From one hundred twenty five retrieved titles, 12 (three case control study and 9 case reports) articles met inclusion criteria. All of the included studies indicated dysfunction of electron transport chain in autism. The mitochondrial electron transfer chain seems impaired in some children with autism and ROS production is additionally enhanced. It is hypothesized that interventions involving alternative electron shuttling may improve autism through lowering the production of ROS. In addition, it is expected that this alternative electron shuttling to cytochrome c might enhance the production of ATP which is impaired in the disorder. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
C1 [Ghanizadeh, Ahmad; Farrashbandi, Hassan; Shoushtari, Ali Alavi] Shiraz Univ Med Sci, Hafez Hosp, Res Ctr Psychiat & Behav Sci, Shiraz, Iran.
[Ghanizadeh, Ahmad; Farrashbandi, Hassan; Shoushtari, Ali Alavi] Shiraz Univ Med Sci, Sch Med, Dept Psychiat, Shiraz, Iran.
[Berk, Michael; Villagonzalo, Kristi-Ann] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia.
[Berk, Michael] Univ Melbourne, Orygen Res Ctr, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic 3010, Australia.
[Berk, Michael] Univ Melbourne, Dept Psychiat, Melbourne, Vic 3010, Australia.
RP Farrashbandi, H (reprint author), Shiraz Univ Med Sci, Hafez Hosp, Dept Psychiat, Res Ctr Psychiat & Behav Sci, Shiraz, Iran.
EM farrashh@sums.ac.ir
RI Berk, Michael/M-7891-2013
OI Berk, Michael/0000-0002-5554-6946
FU Simons Autism Foundation; NIH, Cooperative Research Centre; Cancer
Council of Victoria; Stanley Medical Research Foundation; MBF; NHMRC;
Beyond Blue; Rotary Health; Geelong Medical Research Foundation; Bristol
Myers Squibb; Eli Lilly; Glaxo SmithKline; Organon; Novartis; Mayne
Pharma; Servier
FX MB has received Grant/Research Support from the NIH, Cooperative
Research Centre, Simons Autism Foundation, Cancer Council of Victoria,
Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Rotary
Health, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli
Lilly, Glaxo SmithKline, Organon, Novartis, Mayne Pharma and Servier,
has been a speaker for Astra Zeneca, Bristol Myers Squibb, Eli Lilly,
Glaxo SmithKline, Janssen Cilag, Lundbeck, Merck, Pfizer, Sanofi
Synthelabo, Servier, Solvay and Wyeth, served as a consultant to Astra
Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen
Cilag, Lundbeck Merck and Servier, and is a co-inventor of two
provisional patents regarding the use of NAC and related compounds for
psychiatric indications, which, while assigned to the Mental Health
Research Institute, could lead to personal remuneration upon a
commercialization event.
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NR 60
TC 4
Z9 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
J9 MITOCHONDRION
JI Mitochondrion
PD SEP
PY 2013
VL 13
IS 5
SI SI
BP 515
EP 519
DI 10.1016/j.mito.2012.10.001
PG 5
WC Cell Biology; Genetics & Heredity
SC Cell Biology; Genetics & Heredity
GA 210YF
UT WOS:000323870600016
PM 23063712
ER
PT J
AU Kenworthy, L
Yerys, BE
Weinblatt, R
Abrams, DN
Wallace, GL
AF Kenworthy, Lauren
Yerys, Benjamin E.
Weinblatt, Rachel
Abrams, Danielle N.
Wallace, Gregory L.
TI Motor Demands Impact Speed of Information Processing in Autism Spectrum
Disorders
SO NEUROPSYCHOLOGY
LA English
DT Article
DE autism spectrum disorder; processing speed; motor abilities;
communication
ID HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; COGNITIVE-ABILITIES;
INSPECTION TIME; WISC-IV; CHILDREN; INTELLIGENCE; IMPAIRMENT; DYSPRAXIA;
ADHD
AB The apparent contradiction between preserved or even enhanced perceptual processing speed on inspection time tasks in autism spectrum disorders (ASD) and impaired performance on complex processing speed tasks that require motor output (e.g., Wechsler Processing Speed Index) has not yet been systematically investigated. This study investigates whether adding motor output demands to an inspection time task impairs ASD performance compared to that of typically developing control (TDC) children. The performance of children with ASD (n = 28; mean Full Scale IQ (FSIQ) = 115) and TDC (n = 25; mean FSIQ = 122) children was compared on processing speed tasks with increasing motor demand. Correlations were run between ASD task performance and Autism Diagnostic Observation Schedule (ADOS) Communication scores. Performance by the ASD and TDC groups on a simple perceptual processing speed task with minimal motor demand was equivalent, though it diverged (ASD worse than TDC) on 2 tasks with the same stimuli but increased motor output demands. ASD performance on the moderate but not the high speeded motor output demand task was negatively correlated with ADOS communication symptoms. These data address the apparent contradiction between preserved inspection time in the context of slowed "processing speed" in ASD. They show that processing speed is preserved when motor demands are minimized, but that increased motor output demands interfere with the ability to act on perceptual processing of simple stimuli. Reducing motor demands (e.g., through the use of computers) may increase the capacity of people with ASD to demonstrate good perceptual processing in a variety of educational, vocational, and social settings.
C1 [Kenworthy, Lauren; Yerys, Benjamin E.; Weinblatt, Rachel; Abrams, Danielle N.] Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, Rockville, MD 20850 USA.
[Yerys, Benjamin E.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Wallace, Gregory L.] NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA.
RP Kenworthy, L (reprint author), Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, 15245 Shady Grove Rd,Suite 350, Rockville, MD 20850 USA.
EM lkenwort@cnmc.org
FU NIH, National Institute of Mental Health Intramural Research Program;
NIH, National Institute of Mental Health [K23MH086111]; Singer Family
Foundation; Isadore and Bertha Gudelsky Family Foundation
FX We thank the children and families who offered their time for the
current study. We also thank Mike Anderson for use of task stimuli.
There are no conflicts of interest, financial or otherwise, for the
authors involved directly or indirectly with this article. Lauren
Kenworthy and Gregory L. Wallace were supported by the NIH, National
Institute of Mental Health Intramural Research Program. Benjamin E.
Yerys was supported by a K23 Career Development Award from the NIH,
National Institute of Mental Health (K23MH086111). Lauren Kenworthy and
Benjamin E. Yerys were also supported by awards from The Singer Family
Foundation and The Isadore and Bertha Gudelsky Family Foundation.
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Wechsler D, 1999, WECHSLER ABBREVIATED
Yoran-Hegesh R, 2009, PSYCHIAT RES, V166, P35, DOI 10.1016/j.psychres.2007.11.015
NR 28
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD SEP
PY 2013
VL 27
IS 5
BP 529
EP 536
DI 10.1037/a0033599
PG 8
WC Psychology, Clinical; Neurosciences; Psychology
SC Psychology; Neurosciences & Neurology
GA 212VV
UT WOS:000324011800003
PM 23937483
ER
PT J
AU Yerys, BE
Kenworthy, L
Jankowski, KF
Strang, J
Wallace, GL
AF Yerys, Benjamin E.
Kenworthy, Lauren
Jankowski, Kathryn F.
Strang, John
Wallace, Gregory L.
TI Separate Components of Emotional Go/No-Go Performance Relate to Autism
Versus Attention Symptoms in Children With Autism
SO NEUROPSYCHOLOGY
LA English
DT Article
DE autism; attention-deficit/hyperactivity disorder; cognitive control;
response inhibition; emotion
ID DEFICIT/HYPERACTIVITY DISORDER; EXECUTIVE FUNCTIONS; SPECTRUM DISORDERS;
SUSTAINED ATTENTION; ADHD; HYPERACTIVITY; ENDOPHENOTYPES; INDIVIDUALS;
IMPAIRMENT; INTERVIEW
AB Objective: The present investigation examined whether higher functioning children with autism would demonstrate impaired response inhibition performance in an emotional go/no-go task, and whether severity of attention-deficit/hyperactivity disorder (ADHD) or autism symptoms correlated with performance. Method: Forty-four children (21 meeting criteria for autism; 23 typically developing controls [TDCs]) completed an emotional go/no-go task in which an emotional facial expression (angry, fearful, happy, or sad) was the go stimulus and a neutral facial expression was the no-go stimulus, and vice versa. Results: The autism group was faster than the TDC group on all emotional go,trials. Moreover, the children in the autism group who had the fastest reaction times on emotional go trials were rated as having the greatest number of symptoms (Autism Diagnostic Observation Schedule Social + Communication score), even after accounting for the association with ADHD symptoms. The autism group also made more impulsive responses (i.e., lower d', more false alarms) than the TDC group on all trials. As d' decreased or false alarms increased, so. did ADHD symptoms. Hyperactivity/impulsivity symptoms were significantly correlated with false alarms, but inattention symptoms were not. There was not a significant relationship between no-go false alarms and autism symptoms; even after partialing out associations with autism symptoms, the significant correlation between ADHD symptoms and no-go false alarms remained. Conclusion: The present findings support a comorbidity model that argues for shared and independent risk factors, because ADHD and autism symptoms related to independent aspects of emotional go/no-go performance.
C1 [Yerys, Benjamin E.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Yerys, Benjamin E.; Kenworthy, Lauren; Jankowski, Kathryn F.; Strang, John] Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, Washington, DC 20010 USA.
[Yerys, Benjamin E.; Kenworthy, Lauren; Jankowski, Kathryn F.; Strang, John] Childrens Natl Med Ctr, Childrens Res Inst, Washington, DC 20010 USA.
[Wallace, Gregory L.] NIMH, Lab Brain & Cognit, Intramural Res Program, Bethesda, MD 20892 USA.
RP Yerys, BE (reprint author), Ctr Autism Res, 3535 Market St,Suite 860, Philadelphia, PA 19104 USA.
EM yerysb@email.chop.edu
FU Intramural Research Program of the National Institutes of Health,
National Institute of Mental Health; Isadore and Bertha Gudelsky
Foundation; Elizabeth and Frederick Singer Foundation; National
Institute of Mental Health [K23MH086111, R21MH092615]
FX We thank the families for volunteering their time and effort to
participate in our studies. This research was supported in part by the
Intramural Research Program of the National Institutes of Health,
National Institute of Mental Health, Isadore and Bertha Gudelsky
Foundation, the Elizabeth and Frederick Singer Foundation, and the
National Institute of Mental Health Awards K23MH086111 (PI: Benjamin E.
Yerys) and R21MH092615 (PI: Benjamin E. Yerys). We thank Rachel
Weinblatt and Jennifer Sokoloff from the Center for Autism Spectrum
Disorders at Children's National Medical Center for their assistance in
data collection. The content is solely the responsibility of the authors
and does not necessarily represent the official views of the National
Institute of Mental Health or the National Institutes of Health.
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NR 43
TC 2
Z9 2
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD SEP
PY 2013
VL 27
IS 5
BP 537
EP 545
DI 10.1037/a0033615
PG 9
WC Psychology, Clinical; Neurosciences; Psychology
SC Psychology; Neurosciences & Neurology
GA 212VV
UT WOS:000324011800004
PM 23937480
ER
PT J
AU Russell-Smith, SN
Bayliss, DM
Maybery, MT
AF Russell-Smith, Suzanna N.
Bayliss, Donna M.
Maybery, Murray T.
TI Unique sets of social and mood characteristics differentiate autistic
and negative schizotypy traits in a young adult non-clinical sample
SO PERSONALITY AND INDIVIDUAL DIFFERENCES
LA English
DT Article
DE Autism; Schizotypy; Autism Spectrum Quotient; Oxford-Liverpool Inventory
of Feelings and Experiences; Social; Mood
ID INTERACTION ANXIETY; FUNCTIONING AUTISM; SPECTRUM QUOTIENT; EMPATHY
QUOTIENT; SCALE; DISORDER
AB While well-established as distinct disorders, new evidence linking autism and schizophrenia has emerged. One line of evidence is the strong correlation identified between the social traits assessed by the Autism Spectrum Quotient (AQ:Social) and the negative traits of schizotypy. To further explore this association, the current study examined whether these sets of traits are convergent or divergent in the degree to which they relate to specific aspects of socio-emotional functioning. Regression analyses conducted on self-report data collected from 284 undergraduate students showed that the social items from the AQ uniquely relate to levels of social anxiety and social skills, while negative schizotypy traits uniquely relate to social anhedonia and depression. Additionally, AQ:Social and negative schizotypy traits were found to share a significant proportion of variance, independent of each of the socio-emotional variables examined. The results thus provide further evidence of shared atypical social function linked to both autistic-like traits and negative. schizotypy traits, but importantly also highlight clear differences in the specific socio-emotional profiles associated with these sets of traits. (c) 2013 Elsevier Ltd. All rights reserved.
C1 [Russell-Smith, Suzanna N.; Bayliss, Donna M.; Maybery, Murray T.] Univ Western Australia, Neurocognit Dev Unit, Sch Psychol, Crawley, WA 6009, Australia.
RP Russell-Smith, SN (reprint author), Univ Western Australia, Neurocognit Dev Unit, Sch Psychol, M304 35 Stirling Hwy, Crawley, WA 6009, Australia.
EM suzanna.russell-smith@uwa.edu.au
RI Maybery, Murray/H-5390-2014; Bayliss, Donna/H-8810-2014
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NR 32
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0191-8869
J9 PERS INDIV DIFFER
JI Pers. Individ. Differ.
PD SEP
PY 2013
VL 55
IS 5
BP 542
EP 546
DI 10.1016/j.paid.2013.04.030
PG 5
WC Psychology, Social
SC Psychology
GA 191JZ
UT WOS:000322410500017
ER
PT J
AU Carey, JM
Cassels, TG
AF Carey, Jasmine M.
Cassels, Tracy G.
TI Comparing Two Forms of a Childhood Perspective-Taking Measure Using CFA
and IRT
SO PSYCHOLOGICAL ASSESSMENT
LA English
DT Article
DE perspective-taking; emotion identification; autism spectrum disorders;
childhood; item response theory
ID CONFIRMATORY FACTOR-ANALYSIS; MENTAL-STATE LANGUAGE;
AGGRESSIVE-BEHAVIOR; PSYCHOPATHIC TENDENCIES; FUNCTIONING AUTISM; FACIAL
EXPRESSIONS; ASPERGER-SYNDROME; MIND; CHILDREN; VARIABLES
AB Deficits in perspective-taking ability have been linked to social problems associated with disorders such as autism spectrum disorders (ASD) and conduct disorder. Even subtle deficits in perspective-taking are related to social adjustment and moral development. A common measure of perspective-taking abilities in children is the "Reading the Mind in the Eyes Task" ("Eyes task"; Baron-Cohen, Wheelwright, Spong, Scahill, & Lawson, 2001). The Eyes task was primarily developed for use in identifying individuals with ASDs, while its function with nonclinical populations has not been clearly addressed. Additionally, it is unknown whether the Eyes task can be used to measure specific deficits or abilities in the cognitive or emotional components of perspective-taldng. In this article we assessed the structure and function of the Eyes task and an open ended or generative format of the same task (Generative Eyes Task; GET) found to measure emotional perspective-taking specifically. Confirmatory factor analyses found the traditional Eyes task to have the assumed single factor structure, while the GET has a clear 2-factor structure corresponding to emotionally valenced or neutral items. The Eyes task and the GET were also compared using item response theory. The Eyes task provided the most measurement accuracy at 2 standard deviations below the mean making it most accurate for populations with severe deficits, while the GET was most accurate at the mean level of perspective-taking. Based on these analyses, we conclude that the GET is more appropriate for use in nonclinical populations and when emotional perspective-taking abilities are of interest.
C1 [Carey, Jasmine M.; Cassels, Tracy G.] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada.
RP Carey, JM (reprint author), Univ British Columbia, Dept Psychol, 2136 W Mall, Vancouver, BC V6T 1Z4, Canada.
EM jcarey@psych.ubc.ca
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NR 45
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1040-3590
J9 PSYCHOL ASSESSMENT
JI Psychol. Assess.
PD SEP
PY 2013
VL 25
IS 3
BP 879
EP 892
DI 10.1037/a0032641
PG 14
WC Psychology, Clinical
SC Psychology
GA 212PH
UT WOS:000323994800018
PM 23647048
ER
PT J
AU Brock, J
Bzishvili, S
AF Brock, Jon
Bzishvili, Samantha
TI Deconstructing Frith and Snowling's homograph-reading task: Implications
for autism spectrum disorders
SO QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY
LA English
DT Article
DE Homographs; Eye movements; Speech production; Autism; Experimental
design
ID CENTRAL COHERENCE; EYE-MOVEMENTS; WEAK COHERENCE; LANGUAGE; CONTEXT;
CHILDREN; MIND
AB The poor performance of autistic individuals on a test of homograph reading is widely interpreted as evidence for a reduction in sensitivity to context termed weak central coherence. To better understand the cognitive processes involved in completing the homograph-reading task, we monitored the eye movements of nonautistic adults as they completed the task. Using single trial analysis, we determined that the time between fixating and producing the homograph (eye-to-voice span) increased significantly across the experiment and predicted accuracy of homograph pronunciation, suggesting that participants adapted their reading strategy to minimize pronunciation errors. Additionally, we found evidence for interference from previous trials involving the same homograph. This progressively reduced the initial advantage for dominant homograph pronunciations as the experiment progressed. Our results identify several additional factors that contribute to performance on the homograph reading task and may help to reconcile the findings of poor performance on the test with contradictory findings from other studies using different measures of context sensitivity in autism. The results also undermine some of the broader theoretical inferences that have been drawn from studies of autism using the homograph task. Finally, we suggest that this approach to task deconstruction might have wider applications in experimental psychology.
C1 [Brock, Jon] Macquarie Univ, Dept Cognit Sci, Sydney, NSW 2109, Australia.
[Bzishvili, Samantha] Macquarie Univ, Dept Psychol, Sydney, NSW 2109, Australia.
RP Brock, J (reprint author), Macquarie Univ, Dept Cognit Sci, Sydney, NSW 2109, Australia.
EM jon.brock@mq.edu.au
FU Australian Research Council [DP098466]; Macquarie University
FX This research was supported by Australian Research Council Discovery
Project DP098466 and a Macquarie University Research Development Grant.
We thank Joann Tang for assistance with data processing, Reinhold Kliegl
for advice regarding statistical analyses, and Sachiko Kinoshita for
comments on an earlier draft.
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NR 20
TC 2
Z9 2
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 1747-0218
J9 Q J EXP PSYCHOL
JI Q. J. Exp. Psychol.
PD SEP 1
PY 2013
VL 66
IS 9
BP 1764
EP 1773
DI 10.1080/17470218.2013.766221
PG 10
WC Psychology, Biological; Physiology; Psychology; Psychology, Experimental
SC Psychology; Physiology
GA 212SD
UT WOS:000324002200007
PM 23425364
ER
PT J
AU Reese, RM
Jamison, R
Wendland, M
Fleming, K
Braun, MJ
Schuttler, JO
Turek, J
AF Reese, R. Matthew
Jamison, Rene
Wendland, Maura
Fleming, Kandace
Braun, Matthew J.
Schuttler, Jessica Oeth
Turek, Josh
TI Evaluating Interactive Videoconferencing for Assessing Symptoms of
Autism
SO TELEMEDICINE AND E-HEALTH
LA English
DT Article
DE autism; diagnosis; videoconferencing; Autism Diagnostic Observation
Schedule; Autism Diagnostic Interview-Revised; parent satisfaction
ID HEALTH-CARE NEEDS; SPECTRUM DISORDERS; CHILDREN; DIAGNOSIS;
IDENTIFICATION; TELEMEDICINE; TELEHEALTH
AB Background: Autism affects as many as 1 in 88 children. Best practices recommend early identification and intervention for optimal outcomes. Currently, a gap exists between time of first concern and diagnosis, particularly for families living in rural areas. Telemedicine as a tool for assessment and diagnosis of autism is one way to address this disparity. Emerging evidence suggests telemedicine as a viable option for assessing children with a variety of special needs.Materials and Methods:This study expands upon the current literature by investigating clinicians' ability to assess autism via telemedicine. Using interactive videoconferencing, we simulated autism assessment procedures with families with an existing diagnosis (autism or developmental disability) using current gold-standard assessment tools. We compared diagnostic accuracy, item-by-item reliability on the Autism Diagnostic Observation Schedule (ADOS)Module 1, and the Autism Diagnostic InterviewRevised (ADI-R) as well as parent satisfaction in an in-person and interactive videoconferencing condition. Ten children (3-5 years old) with developmental delays and 11 children matched on chronological age with a diagnosis of autism were assigned to be assessed and interviewed either in-person or over videoconferencing. Clinicians observed both in-person and through videoconferencing regardless of patient assignment.Results:Results indicated no significant difference in reliability of diagnostic accuracy, ADOS observations, ratings for ADI-R parent report of symptoms, and parent satisfaction between conditions. Results indicate adequate clinician agreement and parent satisfaction regardless of observational condition.Conclusions:Future research should include a larger sample size and assess children without an existing diagnosis.
C1 [Reese, R. Matthew; Jamison, Rene; Wendland, Maura; Braun, Matthew J.; Schuttler, Jessica Oeth] Univ Kansas, Med Ctr, Ctr Child Hlth & Dev, Kansas City, KS 66160 USA.
[Fleming, Kandace; Turek, Josh] Univ Kansas, Bur Child Res, Lawrence, KS 66045 USA.
RP Reese, RM (reprint author), Univ Kansas, Med Ctr, Ctr Child Hlth & Dev, Kansas City, KS 66160 USA.
EM mreese1@kumc.edu
FU Department of Defense Autism Concept [W81XWH-08-1-0233]
FX A Department of Defense Autism Concept grant (number W81XWH-08-1-0233)
provided funding for this pilot project. The Center for Telemedicine and
Telehealth at the University of Kansas Medical Center provided ongoing
technical support during the project with consultation and support from
Dave Cook, Eve-Lynn Nelson, and Ryan Spaulding.
CR American Telemedicine Association, 2012, TEL DEF
Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
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NR 23
TC 4
Z9 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-5627
J9 TELEMED E-HEALTH
JI Telemed. e-Health
PD SEP 1
PY 2013
VL 19
IS 9
BP 671
EP 677
DI 10.1089/tmj.2012.0312
PG 7
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA 213KS
UT WOS:000324056600005
PM 23870046
ER
PT J
AU Montag, C
Brockmann, EM
Bayerl, M
Rujescu, D
Muller, DJ
Gallinat, J
AF Montag, Christiane
Brockmann, Eva-Maria
Bayerl, Martin
Rujescu, Dan
Mueller, Daniel J.
Gallinat, Juergen
TI Oxytocin and oxytocin receptor gene polymorphisms and risk for
schizophrenia: A case-control study
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Oxytocin; oxytocin receptor genes; schizophrenia; case-control study;
SNP rs53576
ID ONSET MOOD DISORDERS; CEREBROSPINAL-FLUID; SOCIAL-BEHAVIOR; OXTR GENE;
AFFILIATIVE BEHAVIOR; CANDIDATE GENES; AUTISM; VASOPRESSIN; ASSOCIATION;
HUMANS
AB Objectives. Dysfunctions of the "social brain" belong to the core features of schizophrenia. The neurohormone oxytocin (OXT), mediated through its specific receptor (OXTR), is involved in the regulation of social behaviour and social cognition. Previous research has suggested a role of OXT system genes in disorders of social reciprocity. Preliminary evidence points to an association of peripheral OXT levels as well as OXT and OXTR gene polymorphisms with psychotic symptoms and treatment response in schizophrenia. This study aims to determine a possible contribution of OXT and OXTR genetic variations to schizophrenia susceptibility. Methods. Using n = 406 individuals diagnosed with schizophrenia according to DSM-IV and n = 406 healthy controls matched for age and gender in a case-control design, two single nucleotide polymorphisms (SNPs) within the OXT gene (rs2740204, rs2740210) and four SNPs within the OXTR gene (rs53576, rs237880, rs237885, rs237902) that were previously investigated in other studies were geno-typed. Results. Chi(2)-testing suggested significant associations of OXTR SNPs rs53576(A > G) (P = 0.008) and rs237885(T > G) (P = 0.025) with a diagnosis of schizophrenia. Post-hoc ANCOVA revealed significant associations of OXTR SNPs rs53576 with general psychopathology and rs237902 with negative symptom scores in schizophrenic patients. Conclusions. Our findings support hypotheses about an involvement of oxytocinergic gene variants in schizophrenia vulnerability and warrant independent replication.
C1 [Montag, Christiane; Brockmann, Eva-Maria; Bayerl, Martin; Gallinat, Juergen] Charite, Dept Psychiat & Psychotherapy, D-10117 Berlin, Germany.
[Rujescu, Dan] Univ Munich LMU, Dept Psychiat, Munich, Germany.
[Mueller, Daniel J.] Univ Toronto, Dept Psychiat, Ctr Addict & Mental Hlth, Neurogenet Sect, Toronto, ON, Canada.
RP Montag, C (reprint author), Charite, Campus Mitte PUK Charite SHK,Charitepl 1, D-10117 Berlin, Germany.
EM christiane.montag@charite.de
FU CIHR; OMHF
FX CIHR Michael Smith New Investigator Salary Prize for Research in
Schizophrenia to DJM, OMHF New Investigator Fellowship to DJM.
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NR 85
TC 12
Z9 13
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1562-2975
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD SEP
PY 2013
VL 14
IS 7
BP 500
EP 508
DI 10.3109/15622975.2012.677547
PG 9
WC Psychiatry
SC Psychiatry
GA 218AB
UT WOS:000324403800004
PM 22651577
ER
PT J
AU Toma, C
Hervas, A
Balmana, N
Salgado, M
Maristany, M
Vilella, E
Aguilera, F
Orejuela, C
Cusco, I
Gallastegui, F
Perez-Jurado, LA
Caballero-Andaluz, R
De Diego-Otero, Y
Guzman-Alvarez, G
Ramos-Quiroga, JA
Ribases, M
Bayes, M
Cormand, B
AF Toma, Claudio
Hervas, Amaia
Balmana, Noemi
Salgado, Marta
Maristany, Marta
Vilella, Elisabet
Aguilera, Francisco
Orejuela, Carmen
Cusco, Ivon
Gallastegui, Fatima
Alberto Perez-Jurado, Luis
Caballero-Andaluz, Rafaela
De Diego-Otero, Yolanda
Guzman-Alvarez, Guadalupe
Antoni Ramos-Quiroga, Josep
Ribases, Marta
Bayes, Monica
Cormand, Bru
TI Neurotransmitter systems and neurotrophic factors in autism: association
study of 37 genes suggests involvement of DDC
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Genetics; autistic disorder; serotonin; dopamine; DDC gene
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL
DISORDERS; SINGLE-NUCLEOTIDE POLYMORPHISMS; GENOME-WIDE ASSOCIATION;
SPECTRUM DISORDERS; DOPA DECARBOXYLASE; LINKAGE DISEQUILIBRIUM; MAJOR
DEPRESSION; BDNF GENE; SEROTONIN
AB Objectives. Neurotransmitter systems and neurotrophic factors can be considered strong candidates for autism spectrum disorder (ASD). The serotoninergic and dopaminergic systems are involved in neurotransmission, brain maturation and cortical organization, while neurotrophic factors (NTFs) participate in neurodevelopment, neuronal survival and synapses formation. We aimed to test the contribution of these candidate pathways to autism through a case-control association study of genes selected both for their role in central nervous system functions and for pathophysiological evidences. Methods. The study sample consisted of 326 unrelated autistic patients and 350 gender-matched controls from Spain. We genotyped 369 tagSNPs to perform a case-control association study of 37 candidate genes. Results. A significant association was obtained between the DDC gene and autism in the single-marker analysis (rs6592961, P = 0.00047). Haplotype-based analysis pinpointed a four-marker combination in this gene associated with the disorder (rs2329340C-rs2044859T-rs6592961A-rs11761683T, P = 4.988e-05). No significant results were obtained for the remaining genes after applying multiple testing corrections. However, the rs167771 marker in DRD3, associated with ASD in a previous study, displayed a nominal association in our analysis (P = 0.023). Conclusions. Our data suggest that common allelic variants in the DDC gene may be involved in autism susceptibility.
C1 [Toma, Claudio; Cormand, Bru] Univ Barcelona, Fac Biol, Dept Genet, E-08028 Barcelona, Spain.
[Hervas, Amaia; Balmana, Noemi; Salgado, Marta] Hosp Univ Mutua Terrassa, Child & Adolescent Mental Hlth Unit, Barcelona, Spain.
[Maristany, Marta] Hosp St Joan de Deu, Dev Disorders Unit UETD, Esplugues Llobregat, Barcelona, Spain.
[Vilella, Elisabet] Univ Rovira & Virgili, Hosp Psiquiatr Univ Inst Pere Mata, IISPV, E-43201 Reus, Spain.
[Aguilera, Francisco; Orejuela, Carmen] Fundacio Villablanca, Grp Pere Mata, Intellectual Disabil & Dev Disorders Res Unit UNI, Reus, Spain.
[Cusco, Ivon; Gallastegui, Fatima; Alberto Perez-Jurado, Luis] Univ Pompeu Fabra, Unitat Genet, Barcelona, Spain.
[Alberto Perez-Jurado, Luis] Hosp Univ Vall dHebron, Programa Med Mol & Genet, Barcelona, Spain.
[Caballero-Andaluz, Rafaela] Univ Seville, Dept Psychiat, Autism Unit, Seville, Spain.
[De Diego-Otero, Yolanda] Hosp Carlos Haya, Lab Invest Fdn IMABIS, Malaga, Spain.
[Guzman-Alvarez, Guadalupe] Univ Virgen de la Victoria Malaga, Unidad Psiquiatria Infanto Juvenil Hosp Clin, Malaga, Spain.
[Antoni Ramos-Quiroga, Josep; Ribases, Marta] Hosp Univ Vall dHebron, Dept Psychiat, Barcelona, Spain.
[Antoni Ramos-Quiroga, Josep] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, E-08193 Barcelona, Spain.
[Ribases, Marta] Vall dHebron Res Inst VHIR, Psychiat Genet Unit, Barcelona, Spain.
RP Cormand, B (reprint author), Univ Barcelona, Fac Biol, Dept Genet, Av Diagonal 645,Edifici Annex,3 Planta, E-08028 Barcelona, Spain.
EM bcormand@ub.edu
RI Cusco, I/H-2096-2014; Toma, Claudio/L-7853-2014
OI Cusco, I/0000-0003-2104-9332; Toma, Claudio/0000-0003-3901-7507
FU Instituto de Salud Carlos III-FIS [PI041267, PI042010, PI040524, RETICS
G03/183, PI042209, PI041208, PI070539]; Consejer a de Innovacion,
Ciencia y Empresa; Junta de Andalucia [CTS-546]; Fundacio La Marato de
TV3 [092010]; Fundacion Alicia Koplowitz; Agencia de Gestio d'Ajuts
Universitaris i de Recerca-AGAUR [2009GR00971]
FX We are grateful to all patients and controls for their participation in
our study, to clinical collaborators (Montse Causi, Carlota Pont, Julia
Ruiz, Inma Planelles, Mar Margalef, Mar Fernandez, David Segu and Blanca
Gener) for patients' assessment, to Luc a Madrigal for blood sampling,
to Olaya Villa for cytogenetic analyses, to M. Dolors Castellar and
others from the "Banc de Sang i Teixits" (Hospital Universitari Vall
d'Hebron) for their collaboration in the recruitment of controls, to
Monica Gratacos for her participation in the selection of part of the
studied genes and polymorphisms, and to Miquel Casas for critical
comments. Genotyping services were provided by the Spanish "Centro
Nacional de Genotipado" (CEGEN; www.cegen.org). MR is a recipient of a
Miguel de Servet contract from "Instituto de Salud Carlos III" (Spain)
and CT was supported by fellowships from the Biomedical Network Research
Centre on Rare Diseases (CIBERER) and the European Union (Marie Curie,
PIEF-GA-2009-254930). Financial support was received from "Instituto de
Salud Carlos III-FIS" (PI041267, PI042010, PI040524, RETICS G03/183,
PI042209, PI041208 and PI070539), "Consejer a de Innovacion, Ciencia y
Empresa", Junta de Andalucia (CTS-546), "Fundacio La Marato de TV3"
(092010), Fundacion Alicia Koplowitz and "Agencia de Gestio d'Ajuts
Universitaris i de Recerca-AGAUR" (2009GR00971). These institutions had
no further role in study design; in the collection, analysis and
interpretation of data; in the writing of the report; and in the
decision to submit the paper for publication.
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NR 73
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1562-2975
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD SEP
PY 2013
VL 14
IS 7
BP 516
EP 527
DI 10.3109/15622975.2011.602719
PG 12
WC Psychiatry
SC Psychiatry
GA 218AB
UT WOS:000324403800006
PM 22397633
ER
PT J
AU Abdallah, MW
Larsen, N
Grove, J
Norgaard-Pedersen, B
Thorsen, P
Mortensen, EL
Hougaard, DM
AF Abdallah, Morsi W.
Larsen, Nanna
Grove, Jakob
Norgaard-Pedersen, Bent
Thorsen, Poul
Mortensen, Erik L.
Hougaard, David M.
TI Amniotic fluid inflammatory cytokines: Potential markers of immunologic
dysfunction in autism spectrum disorders
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autistic disorder; amniotic fluid; cytokines; birth cohort; maternal
immune activation
ID AUTOIMMUNE-DISEASES; CHILDREN; ASSOCIATION; INFECTION; COHORT; BRAIN;
SCHIZOPHRENIA; PREVALENCE; ACTIVATION; MECHANISMS
AB Objectives. The aim of the study was to analyze cytokine profiles in amniotic fluid (AF) samples of children developing autism spectrum disorders (ASD) and controls, adjusting for maternal autoimmune disorders and maternal infections during pregnancy. Methods. AF samples of 331 ASD cases and 698 controls were analyzed for inflammatory cytokines using Luminex xMAP technology utilizing a historic birth cohort. Clinical data were retrieved from nationwide registers, and case-control differences in AF cytokine levels were assessed using chi-square tests, logistic and tobit regression models. Results. Overall, individuals with ASD had significantly elevated AF levels of TNF-alpha and TNF-beta compared to controls. Analyzing individuals diagnosed only with ICD-10 codes yielded significantly elevated levels of IL-4, IL-10, TNF-a and TNF-beta in ASD patients. Restricting analysis to infantile autism cases showed significantly elevated levels of IL-4, TNF-a and TNF-beta compared to controls with no psychiatric comorbidities. Elevated levels of IL-6 and IL-5 were found in individuals with other childhood psychiatric disorders (OCPD) when compared to controls with no psychiatric comorbidities. Conclusions. AF samples of individuals with ASD or OCPD showed differential cytokine profiles compared to frequency-matched controls. Further studies to examine the specificity of the reported cytokine profiles in ASD and OCPD are required.
C1 [Abdallah, Morsi W.] Aarhus Univ, Fac Hlth Sci, Dept Epidemiol, Aarhus, Denmark.
[Abdallah, Morsi W.; Larsen, Nanna; Norgaard-Pedersen, Bent; Hougaard, David M.] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen, Denmark.
[Abdallah, Morsi W.; Mortensen, Erik L.] Univ Copenhagen, Inst Publ Hlth, DK-1014 Copenhagen K, Denmark.
[Abdallah, Morsi W.; Mortensen, Erik L.] Univ Copenhagen, Ctr Hlth Aging, DK-1014 Copenhagen K, Denmark.
[Grove, Jakob] Aarhus Univ, Fac Hlth Sci, Dept Biomed, Aarhus, Denmark.
[Grove, Jakob] Aarhus Univ, Bioinformat Res Ctr BiRC, Aarhus, Denmark.
[Thorsen, Poul] Lillebaelt Hosp, Dept Obstet & Gynaecol, Kolding, Denmark.
RP Abdallah, MW (reprint author), Univ Copenhagen, Inst Publ Hlth, Unit Med Psychol, Oster Farimagsgade 5B,CSS 15-0-19,Postboks 2099, DK-1014 Copenhagen K, Denmark.
EM mab@soci.au.dk
FU Danish Medical Research Foundation; Danish Ministry of the Interior and
Health [271-05-0523/09-060179]; Aarhus University Faculty of Health
Sciences, Aarhus, Denmark; Statens Serum Institute, Department of
Clinical Biochemistry and Immunology, Copenhagen, Denmark [494028]
FX The authors thank Lasse S. Jonsson from Statens Serum Institute (SSI)
and Maria Pryds for their assistance in data retrieval and Vibeke Munk
from University of Copenhagen for her administrative assistance. We also
thank SSI Luminex Lab technical staff for their time and efforts. The
Danish Historic Birth Cohort was established at Statens Serum Institute,
Copenhagen with a grant from The Danish Medical Research Foundation and
The Danish Ministry of the Interior and Health (Project no.
271-05-0523/09-060179). This study is funded by Aarhus University
Faculty of Health Sciences, Aarhus, Denmark and Statens Serum Institute,
Department of Clinical Biochemistry and Immunology, Copenhagen, Denmark
(Project Title: Intrauterine Exposures and Childhood Psychiatric
Disorders, Project ID: 494028).
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NR 65
TC 11
Z9 12
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1562-2975
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD SEP
PY 2013
VL 14
IS 7
BP 528
EP 538
DI 10.3109/15622975.2011.639803
PG 11
WC Psychiatry
SC Psychiatry
GA 218AB
UT WOS:000324403800007
PM 22175527
ER
PT J
AU Lai, MC
Lombardo, MV
Suckling, J
Ruigrok, ANV
Chakrabarti, B
Ecker, C
Deoni, SCL
Craig, MC
Murphy, DGM
Bullmore, ET
Baron-Cohen, S
AF Lai, Meng-Chuan
Lombardo, Michael V.
Suckling, John
Ruigrok, Amber N. V.
Chakrabarti, Bhismadev
Ecker, Christine
Deoni, Sean C. L.
Craig, Michael C.
Murphy, Declan G. M.
Bullmore, Edward T.
Baron-Cohen, Simon
CA MRC AIMS Consortium
TI Biological sex affects the neurobiology of autism
SO BRAIN
LA English
DT Article
DE autism; brain; sex differences; volumetric MRI
ID VOXEL-BASED MORPHOMETRY; HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS;
GRAY-MATTER; DIAGNOSTIC INTERVIEW; ASPERGER-SYNDROME; CHILDHOOD AUTISM;
INFANTILE-AUTISM; REVISED VERSION; CEREBRAL-CORTEX
AB In autism, heterogeneity is the rule rather than the exception. One obvious source of heterogeneity is biological sex. Since autism was first recognized, males with autism have disproportionately skewed research. Females with autism have thus been relatively overlooked, and have generally been assumed to have the same underlying neurobiology as males with autism. Growing evidence, however, suggests that this is an oversimplification that risks obscuring the biological base of autism. This study seeks to answer two questions about how autism is modulated by biological sex at the level of the brain: (i) is the neuroanatomy of autism different in males and females? and (ii) does the neuroanatomy of autism fit predictions from the 'extreme male brain' theory of autism, in males and/or in females? Neuroanatomical features derived from voxel-based morphometry were compared in a sample of equal-sized high-functioning male and female adults with and without autism (n = 120, n = 30/group). The first question was investigated using a 2 x 2 factorial design, and by spatial overlap analyses of the neuroanatomy of autism in males and females. The second question was tested through spatial overlap analyses of specific patterns predicted by the extreme male brain theory. We found that the neuroanatomy of autism differed between adult males and females, evidenced by minimal spatial overlap (not different from that occurred under random condition) in both grey and white matter, and substantially large white matter regions showing significant sex x diagnosis interactions in the 2 x 2 factorial design. These suggest that autism manifests differently by biological sex. Furthermore, atypical brain areas in females with autism substantially and non-randomly (P < 0.001) overlapped with areas that were sexually dimorphic in neurotypical controls, in both grey and white matter, suggesting neural 'masculinization'. This was not seen in males with autism. How differences in neuroanatomy relate to the similarities in cognition between males and females with autism remains to be understood. Future research should stratify by biological sex to reduce heterogeneity and to provide greater insight into the neurobiology of autism.
C1 [Lai, Meng-Chuan; Lombardo, Michael V.; Ruigrok, Amber N. V.; Chakrabarti, Bhismadev; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 8AH, England.
[Lai, Meng-Chuan] Natl Taiwan Univ, Dept Psychiat, Coll Med, Taipei 10051, Taiwan.
[Suckling, John; Bullmore, Edward T.] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge CB2 0SZ, England.
[Chakrabarti, Bhismadev] Univ Reading, Sch Psychol & Clin Language Sci, Ctr Integrat Neurosci & Neurodynam, Reading RG6 6AL, Berks, England.
[Ecker, Christine; Craig, Michael C.; Murphy, Declan G. M.] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London SE5 8AF, England.
[Deoni, Sean C. L.] Brown Univ, Sch Engn, Adv Baby Imaging Lab, Providence, RI 02912 USA.
[Bullmore, Edward T.] Addenbrookes Hosp, Clin Unit Cambridge, GlaxoSmithKline, Cambridge CB2 2QQ, England.
[Bullmore, Edward T.; Baron-Cohen, Simon] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England.
RP Lai, MC (reprint author), Univ Cambridge, Dept Psychiat, Autism Res Ctr, Douglas House,18B,Trumpington Rd, Cambridge CB2 8AH, England.
EM mcl45@cam.ac.uk
RI Williams, Steve/D-6979-2011; Ecker, Christine/E-5194-2010; Bolton,
Patrick/E-8501-2010; Bailey, Anthony/J-2860-2014
OI Bolton, Patrick/0000-0002-5270-6262; Bailey, Anthony/0000-0003-4257-972X
FU UK Medical Research Council [GO 400061]; European Autism Interventions-A
Multicentre Study for Developing New Medications (EU-AIMS); European
Union [115300]; Waterloo Foundation [921/1247]; Ministry of Education,
Taiwan; Wellcome Trust; British Academy; Jesus College, Cambridge;
Autism Research Trust; EFPIA; Autism Speaks
FX This work was supported by the UK Medical Research Council [grant number
GO 400061 to D. G. M. M., S. B.-C., E. T. B.]
(http://www.mrc.ac.uk/index.htm) and also received support from the
European Autism Interventions-A Multicentre Study for Developing New
Medications (EU-AIMS, http://www.eu-aims.eu/). The research of EU-AIMS
receives support from the Innovative Medicines Initiative Joint
Undertaking under grant agreement no 115300, resources of which are
composed of financial contribution from the European Union's Seventh
Framework Programme (FP7/2007-2013), from the EFPIA companies in kind
contribution and from Autism Speaks (http://www.autismspeaks.org/).
During the period of this work M.-C. L. was supported by the Waterloo
Foundation [grant number 921/1247]
(http://www.waterloofoundation.org.uk/index.html) and Ministry of
Education, Taiwan (http://english.moe.gov.tw/), M. V. L. by the Wellcome
Trust (http://www.wellcome.ac.uk/), British Academy
(http://www.britac.ac.uk/) and Jesus College, Cambridge
(http://www.jesus.cam.ac.uk/), and S. B.-C. by the Wellcome Trust, the
Autism Research Trust and the UK Medical Research Council. The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
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NR 89
TC 28
Z9 28
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
EI 1460-2156
J9 BRAIN
JI Brain
PD SEP
PY 2013
VL 136
BP 2799
EP 2815
DI 10.1093/brain/awt216
PN 9
PG 17
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 212EM
UT WOS:000323965100018
PM 23935125
ER
PT J
AU Cook, JL
Blakemore, SJ
Press, C
AF Cook, Jennifer L.
Blakemore, Sarah-Jayne
Press, Clare
TI Atypical basic movement kinematics in autism spectrum conditions
SO BRAIN
LA English
DT Article
DE autism; kinematics; biological motion; motor control
ID BIOLOGICAL MOTION PERCEPTION; ARM MOVEMENTS; NEUROANATOMICAL
ABNORMALITIES; MIRROR NEURONS; MOTOR; DISORDERS; CHILDREN; RECOGNITION;
BRAIN; CEREBELLAR
AB Individuals with autism spectrum conditions have difficulties in understanding and responding appropriately to others. Additionally, they demonstrate impaired perception of biological motion and problems with motor control. Here we investigated whether individuals with autism move with an atypical kinematic profile, which might help to explain perceptual and motor impairments, and in principle may contribute to some of their higher level social problems. We recorded trajectory, velocity, acceleration and jerk while adult participants with autism and a matched control group conducted horizontal sinusoidal arm movements. Additionally, participants with autism took part in a biological motion perception task in which they classified observed movements as 'natural' or 'unnatural'. Results show that individuals with autism moved with atypical kinematics; they did not minimize jerk to the same extent as the matched typical control group, and moved with greater acceleration and velocity. The degree to which kinematics were atypical was correlated with a bias towards perceiving biological motion as 'unnatural' and with the severity of autism symptoms as measured by the Autism Diagnostic Observation Schedule. We suggest that fundamental differences in movement kinematics in autism might help to explain their problems with motor control. Additionally, developmental experience of their own atypical kinematic profiles may lead to disrupted perception of others' actions.
C1 [Cook, Jennifer L.; Blakemore, Sarah-Jayne] UCL Inst Cognit Neurosci, London WC1N 3AR, England.
[Cook, Jennifer L.] Radboud Univ Nijmegen, Donders Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands.
[Press, Clare] Univ London, Dept Psychol Sci, London WC1E 7HX, England.
RP Cook, JL (reprint author), Radboud Univ Nijmegen, Donders Ctr Cognit Neuroimaging, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM jennifer.cook@donders.ru.nl
FU Wellcome Trust [082910/Z/07/Z]; Royal Society; AXA
FX This work was supported by a 4 year Wellcome Trust studentship award to
J.C. (grant number 082910/Z/07/Z). S.J.B. is funded by a Royal Society
University Research Fellowship and J.C. is currently funded by an AXA
research fund award. The authors declare no conflicts of interest.
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PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
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PD SEP
PY 2013
VL 136
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EP 2824
DI 10.1093/brain/awt208
PN 9
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 212EM
UT WOS:000323965100019
PM 23983031
ER
PT J
AU Shen, MD
Nordahl, CW
Young, GS
Wootton-Gorges, SL
Lee, A
Liston, SE
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Lee, Aaron
Liston, Sarah E.
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Ozonoff, Sally
Amaral, David G.
TI Early brain enlargement and elevated extra-axial fluid in infants who
develop autism spectrum disorder
SO BRAIN
LA English
DT Article
DE autism; magnetic resonance imaging; infant brain development;
cerebrospinal fluid; external hydrocephalus
ID BENIGN EXTERNAL HYDROCEPHALUS; CEREBROSPINAL-FLUID; SUBARACHNOID SPACE;
CORTICAL DEVELOPMENT; MR-IMAGES; 1ST YEAR; CHILDREN; LIFE; GROWTH; CSF
AB Prospective studies of infants at risk for autism spectrum disorder have provided important clues about the early behavioural symptoms of autism spectrum disorder. Diagnosis of autism spectrum disorder, however, is not currently made until at least 18 months of age. There is substantially less research on potential brain-based differences in the period between 6 and 12 months of age. Our objective in the current study was to use magnetic resonance imaging to identify any consistently observable brain anomalies in 6-9 month old infants who would later develop autism spectrum disorder. We conducted a prospective infant sibling study with longitudinal magnetic resonance imaging scans at three time points (6-9, 12-15, and 18-24 months of age), in conjunction with intensive behavioural assessments. Fifty-five infants (33 'high-risk' infants having an older sibling with autism spectrum disorder and 22 'low-risk' infants having no relatives with autism spectrum disorder) were imaged at 6-9 months; 43 of these (27 high-risk and 16 low-risk) were imaged at 12-15 months; and 42 (26 high-risk and 16 low-risk) were imaged again at 18-24 months. Infants were classified as meeting criteria for autism spectrum disorder, other developmental delays, or typical development at 24 months or later (mean age at outcome: 32.5 months). Compared with the other two groups, infants who developed autism spectrum disorder (n = 10) had significantly greater extra-axial fluid at 6-9 months, which persisted and remained elevated at 12-15 and 18-24 months. Extra-axial fluid is characterized by excessive cerebrospinal fluid in the subarachnoid space, particularly over the frontal lobes. The amount of extra-axial fluid detected as early as 6 months was predictive of more severe autism spectrum disorder symptoms at the time of outcome. Infants who developed autism spectrum disorder also had significantly larger total cerebral volumes at both 12-15 and 18-24 months of age. This is the first magnetic resonance imaging study to prospectively evaluate brain growth trajectories from infancy in children who develop autism spectrum disorder. The presence of excessive extra-axial fluid detected as early as 6 months and the lack of resolution by 24 months is a hitherto unreported brain anomaly in infants who later develop autism spectrum disorder. This is also the first magnetic resonance imaging evidence of brain enlargement in autism before age 2. These findings raise the potential for the use of structural magnetic resonance imaging to aid in the early detection of children at risk for autism spectrum disorder or other neurodevelopmental disorders.
C1 [Shen, Mark D.; Nordahl, Christine W.; Young, Gregory S.; Lee, Aaron; Liston, Sarah E.; Harrington, Kayla R.; Ozonoff, Sally; Amaral, David G.] Univ Calif Davis, UC Davis Sch Med, Med Invest Neurodev Disorders MIND Inst, Sacramento, CA 95817 USA.
[Shen, Mark D.; Nordahl, Christine W.; Young, Gregory S.; Lee, Aaron; Liston, Sarah E.; Harrington, Kayla R.; Ozonoff, Sally; Amaral, David G.] Univ Calif Davis, UC Davis Sch Med, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
[Wootton-Gorges, Sandra L.] Univ Calif Davis, UC Davis Sch Med, Dept Radiol, Sacramento, CA 95817 USA.
[Wootton-Gorges, Sandra L.] Univ Calif Davis, UC Davis Childrens Hosp, Sacramento, CA 95817 USA.
RP Amaral, DG (reprint author), Univ Calif Davis, Sch Med, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA.
EM dgamaral@ucdavis.edu
FU National Institutes of Health [R01MH068398, 1K99MH085099]; UC Davis MIND
Institute
FX This work was supported by the National Institutes of Health
[R01MH068398, 1K99MH085099] and by the UC Davis MIND Institute.
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NR 61
TC 13
Z9 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
J9 BRAIN
JI Brain
PD SEP
PY 2013
VL 136
BP 2825
EP 2835
DI 10.1093/brain/awt166
PN 9
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 212EM
UT WOS:000323965100020
PM 23838695
ER
PT J
AU Chamak, B
Bonniau, B
AF Chamak, B.
Bonniau, B.
TI Changes in the Diagnosis of Autism: How Parents and Professionals Act
and React in France
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Article
DE Autism; Parents' experiences; Diagnosis; Child psychiatry; France
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDER; ASPERGER-SYNDROME;
FRENCH PARENTS; CHILDREN; PREVALENCE; DISABILITY; RECOGNITION;
EXPERIENCES; NARRATIVES
AB The category of autism has undergone huge changes over the past 20 years. This study was undertaken to analyze the changes and how parents have experienced the diagnostic process in France. Data were obtained from in-depth interviews with parents and psychiatrists, and from 248 questionnaires with open-ended questions filled in by parents. We compared the experiences of parents with adult autistic children to those of parents with young autistic children. Progressively earlier age at diagnosis was evidenced. These changes occurred later than in North America and the UK, due to the reluctance of French professionals to adopt the new classifications of diseases which they viewed as undervaluing both the physician's holistic clinical skills, and psychoanalytical interpretations. Parents' experiences and interviews with psychiatrists were analyzed in order to document changes over time in the diagnostic process following tensions between parents and professionals, and intra-professional debates in psychiatry. Our data support the notion that the diagnosis of autism is historically and nationally contingent. The interactions between changes in the diagnostic process, policy, and parental experiences have led to changes in the way autism is defined, understood, and experienced.
C1 [Chamak, B.; Bonniau, B.] Paris Descartes Univ, CERMES3, INSERM, U988,CNRS,UMR 8211,EHESS, F-75270 Paris 06, France.
RP Chamak, B (reprint author), Paris Descartes Univ, CERMES3, INSERM, U988,CNRS,UMR 8211,EHESS, 45 Rue St Peres, F-75270 Paris 06, France.
EM brigitte.chamak@parisdescartes.fr; beatrice.bonniau@parisdescartes.fr
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NR 79
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD SEP
PY 2013
VL 37
IS 3
BP 405
EP 426
DI 10.1007/s11013-013-9323-1
PG 22
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA 209EE
UT WOS:000323736300002
PM 23860618
ER
PT J
AU Chaudhury, S
Nag, TC
Jain, S
Wadhwa, S
AF Chaudhury, Sraboni
Nag, Tapas C.
Jain, Suman
Wadhwa, Shashi
TI Role of sound stimulation in reprogramming brain connectivity
SO JOURNAL OF BIOSCIENCES
LA English
DT Review
DE Auditory pathway; avian; brain; sound stimulation; synaptic plasticity
ID PRENATAL AUDITORY-STIMULATION; BOBWHITE QUAIL CHICKS; PIGEON
COLUMBA-LIVIA; VISUAL-SYSTEM DEVELOPMENT; LONG-TERM ENHANCEMENT;
ENVIRONMENTAL ENRICHMENT; COLINUS-VIRGINIANUS; BACKGROUND MUSIC; SPATIAL
MEMORY; PREFRONTAL CORTEX
AB Sensory stimulation has a critical role to play in the development of an individual. Environmental factors tend to modify the inputs received by the sensory pathway. The developing brain is most vulnerable to these alterations and interacts with the environment to modify its neural circuitry. In addition to other sensory stimuli, auditory stimulation can also act as external stimuli to provide enrichment during the perinatal period. There is evidence that suggests that enriched environment in the form of auditory stimulation can play a substantial role in modulating plasticity during the prenatal period. This review focuses on the emerging role of prenatal auditory stimulation in the development of higher brain functions such as learning and memory in birds and mammals. The molecular mechanisms of various changes in the hippocampus following sound stimulation to effect neurogenesis, learning and memory are described. Sound stimulation can also modify neural connectivity in the early postnatal life to enhance higher cognitive function or even repair the secondary damages in various neurological and psychiatric disorders. Thus, it becomes imperative to examine in detail the possible ameliorating effects of prenatal sound stimulation in existing animal models of various psychiatric disorders, such as autism.
C1 [Chaudhury, Sraboni; Nag, Tapas C.; Wadhwa, Shashi] All India Inst Med Sci, Dept Anat, New Delhi 110029, India.
[Jain, Suman] All India Inst Med Sci, Dept Physiol, New Delhi, India.
RP Chaudhury, S (reprint author), Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA.
EM sraboni@umich.edu
FU Department of Biotechnology, New Delhi [BT/PR3148/BRB/10/276/2002,
BT/PR6771/BRB/10/448/2005]; Council of Scientific and Industrial
Research [37/1242/06 EMRII]
FX The work was financially supported by Department of Biotechnology, New
Delhi (Grant number: BT/PR3148/BRB/10/276/2002 and
BT/PR6771/BRB/10/448/2005 to SW and Council of Scientific and Industrial
Research (no. 37/1242/06 EMRII to SJ).
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NR 120
TC 1
Z9 1
PU INDIAN ACAD SCIENCES
PI BANGALORE
PA C V RAMAN AVENUE, SADASHIVANAGAR, P B #8005, BANGALORE 560 080, INDIA
SN 0250-5991
J9 J BIOSCIENCES
JI J. Biosci.
PD SEP
PY 2013
VL 38
IS 3
BP 605
EP 614
DI 10.1007/s12038-013-9341-8
PG 10
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA 210SM
UT WOS:000323854800016
PM 23938392
ER
PT J
AU Galitsky, B
AF Galitsky, Boris
TI A computational simulation tool for training autistic reasoning about
mental attitudes
SO KNOWLEDGE-BASED SYSTEMS
LA English
DT Article
DE Autistic reasoning; Rehabilitation; Theory of mind
ID BEHAVIORAL TREATMENT; CHILDREN; MIND
AB It has been discovered more than a decade ago that autistic people cannot properly understand and reproduce mental states and emotions. We hypothesize that people with autism suffer from difficulties in learning social rules from examples. Many remediation strategies have not taken this into account. Therefore an appropriate remediation strategy is to teach not simply via examples but to teach the rule along with it. In this study we suggest a reasoning rehabilitation strategy, based on playing with a computer based mental simulator that is capable of modeling mental and emotional states of the real world. A model of the mental world is presented in 12 steps. We describe our implementation of a natural language multiagent system that simulates this model. In addition we describe the system's user interface for autistic rehabilitation. This system is subject to short-term and long-term evaluation of rehabilitation of autistic reasoning. Case studies with children who used it extensively are presented. Implications specifically in terms of autistic rehabilitation as well as generally in terms of reasoning about mental states are discussed. (C) 2013 Elsevier B.V. All rights reserved.
C1 eBay Inc, San Jose, CA USA.
RP Galitsky, B (reprint author), eBay Inc, San Jose, CA USA.
EM boris.galitsky@ebay.com
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NR 64
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0950-7051
J9 KNOWL-BASED SYST
JI Knowledge-Based Syst.
PD SEP
PY 2013
VL 50
BP 25
EP 43
DI 10.1016/j.knosys.2013.04.018
PG 19
WC Computer Science, Artificial Intelligence
SC Computer Science
GA 211AC
UT WOS:000323875500003
ER
PT J
AU Wang, J
AF Wang, Jue
TI Hypothesis on two different functionalities co-existing in frontal lobe
of human brains
SO MEDICAL HYPOTHESES
LA English
DT Article
ID PREFRONTAL CORTEX; DEVELOPMENTAL-CHANGES; ALZHEIMERS-DISEASE; BASE-LINE;
INTELLIGENCE; CONNECTIONS; STIMULUS; AUTISM; DAMAGE; FLUID
AB Human frontal lobe is a key area from where our cognition, memory and emotion display or function. In medical case study, there are patients with social dysfunctions, lack of passion or emotion as result of their frontal lobe damage caused by pathological changes, traumatic damage, and brain tumor remove operations. The syndrome of frontal lobe damage remains at large unanswered medically. From early stage of pregnancy, there exists lobe layers, nerve combine, and neurons synaptic, indicating a completion of growth of functionality inside frontal lobe. However, this completion of growth does not match the growth of human intelligence. Human infants only start and complete their cognition and memory functionality one full year after their birth which is marked by huge amount of neurons synaptic inside their frontal lobe, which is not part of a continual growth of originally developed functions. By reasoning on pathological changes of frontal lobe, a hypothesis was established that two individually functional mechanisms co-existed inside one frontal lobe. This neuron system is particularly for human beings. (C) 2013 Elsevier Ltd. All rights reserved.
RP Wang, J (reprint author), Suite 502,39 Na Chuan Xi Lu, Xi Ning 810012, Qing Hai Prov, Peoples R China.
EM jacob-wang909@hotmail.com
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NR 34
TC 0
Z9 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2013
VL 81
IS 3
BP 367
EP 370
DI 10.1016/j.mehy.2013.06.019
PG 4
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 210ZR
UT WOS:000323874400001
PM 23856241
ER
PT J
AU Frizzo, ME
AF Frizzo, Marcos Emilio
TI Putative role of glycogen as a peripheral biomarker of GSK3 beta
activity
SO MEDICAL HYPOTHESES
LA English
DT Article
ID RABBIT SKELETAL-MUSCLE; DEPENDENT PROTEIN-KINASE; AMINO-ACID-SEQUENCE;
SYNTHASE KINASE-3; PHOSPHORYLASE-KINASE; BLOOD-PLATELETS; SITE;
INHIBITION; EXPRESSION; INSULIN
AB Glycogen synthase kinase 3-beta (GSK3 beta) has a pivotal role in several intracellular signaling cascades that are involved in gene transcription, cytoskeletal reorganization, energy metabolism, cell cycle regulation, and apoptosis. This kinase has pleiotropic functions, and the importance of its activity has recently been shown in neurons and platelets. In addition to its regulatory function in several physiological events, changes in GSK3 beta activity have been associated with many psychiatric and neurodegenerative illnesses, such as Alzheimer's disease, schizophrenia and autism-spectrum disorders. Beside the reports of its involvement in several pathologies, it has become increasingly apparent that GSK3 beta might be a common therapeutic target for different classes of psychiatric drugs, and also that the GSK3 beta ratio may be a useful parameter to determine the biochemical changes that might occur during antidepressant treatment. Although GSK3 beta is commonly described as a key enzyme in a plethora of signaling cascades, originally it was identified as playing an important role in the regulation of glycogen synthesis, given its ability to inactivate glycogen synthase (GS) by phosphorylation. Acting as a constitutively active kinase, GSK3 beta phosphorylates GS, which results in a decrease of glycogen production. GSK3 beta phosphorylation increases glycogen synthesis and storage, while its dephosphorylation decreases glycogen synthesis. Inactivation of GSK3 beta leads to dephosphorylation of GS and increase in glycogen synthesis in the adipose tissue, muscle and liver. Glycogen levels are reduced by antidepressant treatment, and this effect seems to be related to an effect of drugs on GSK3 beta activity. Peripherally, glycogen is also abundantly found in platelets, where it is considered a major energy source, required for a variety of its functions, including the release reaction. Recently, analysis of platelets from patients with late-life major depression showed that active forms of GSK3 beta expression were upregulated by continuous treatment with sertraline. Here, we hypothesized that the quantification of glycogen in platelets might be used as a peripheral biomarker of GSK3 beta activity. Since it has been recently demonstrated that the modulation of GSK3 beta activity causes changes in glycogen stores, the glycogen levels in platelets could be used to assay the effects of drugs that have this kinase as a target, or diseases where its activity is affected. In conclusion, we hypothesized that the determination of glycogen peripherally may be useful to indicate a change in the activity of this enzyme, providing a faster and non-invasive approach to guide the therapeutic procedures for the patient. (C) 2013 Elsevier Ltd. All rights reserved.
C1 Univ Fed Rio Grande do Sul, Dept Morphol Sci, BR-90050170 Porto Alegre, RS, Brazil.
RP Frizzo, ME (reprint author), Univ Fed Rio Grande do Sul, Dept Morphol Sci, Rua Sarmento Leite 500, BR-90050170 Porto Alegre, RS, Brazil.
EM frizzo@ufrgs.br
FU Brazilian National Research Council (CNPq)
FX This research was supported by grants from the Brazilian National
Research Council (CNPq). The author thanks to Dr R.S.M. da Silva and Dr
M.L. Grillo by the revision of manuscript.
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NR 31
TC 1
Z9 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2013
VL 81
IS 3
BP 376
EP 378
DI 10.1016/j.mehy.2013.05.020
PG 3
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 210ZR
UT WOS:000323874400004
PM 23809426
ER
PT J
AU Wachtel, LE
Shorter, E
AF Wachtel, Lee E.
Shorter, Edward
TI Autism plus psychosis: A 'one-two punch' risk for tragic violence?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID INTELLECTUAL DISABILITY; SPECTRUM DISORDERS; AGGRESSIVE-BEHAVIOR;
MENTAL-RETARDATION; PREVALENCE; CRIME; INDIVIDUALS; DIAGNOSIS; HOMICIDE;
ILLNESS
AB In the recent series of mass murders in Connecticut, Colorado, Norway and elsewhere, a pattern appears to emerge: young men whose social isolation borders on autism apparently become prey to psychotic ideation, and under its influence commit horrific violence. We argue that in some of these tragic cases two concomitant diagnoses may be at play, namely autism and psychosis. Autism itself is not an intrinsically violent disorder, and individuals with autism spectrum disorder (ASD) are no more prone to violent behaviors than the general population. The additional presence of psychotic illness, however, may dramatically change the picture. Based on an examination of historical and contemporary data regarding psychosis and violence in patients without developmental disability we explore three points relevant to the possibility of violence in individuals with comorbid ASD and psychosis. (1) Individuals with ASD have an elevated risk of comorbid psychopathology, including psychosis, which is strongly associated with violence. (2) The content of psychotic ideation has become increasingly violent and lethal in recent decades. (3) It is possible that individuals with ASD are readier than others to act on psychotic impulses.
We conclude that there may be a kind of one-two 'vulnerability punch,' giving individuals with ASD a baseline higher risk of comorbid psychiatric illness, not infrequently including psychosis. Recognizing the increased susceptibility of individuals with autism other neurodevelopmental disability to concomitant psychotic illness increases the possibility that they can be correctly identified and treated, mitigating tragic outcomes. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Wachtel, Lee E.] Johns Hopkins Sch Med, Kennedy Krieger Inst, Baltimore, MD 21205 USA.
[Shorter, Edward] Univ Toronto, Fac Med, Hist Med Program, Toronto, ON M5S 3E2, Canada.
RP Shorter, E (reprint author), Univ Toronto, Fac Med, Hist Med Program, 150 Coll St, Toronto, ON M5S 3E2, Canada.
EM wachtel@kennedykrieger.org; history.medici-ne@utoronto.ca
FU Wachtel; Canadian Institutes of Health Research [AMS-94689]
FX Grant support: Wachtel: None to report Shorter: Funded in part by the
Canadian Institutes of Health Research, grant no. AMS-94689.
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NR 50
TC 1
Z9 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2013
VL 81
IS 3
BP 404
EP 409
DI 10.1016/j.mehy.2013.05.032
PG 6
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 210ZR
UT WOS:000323874400011
PM 23786904
ER
PT J
AU Mintz, J
AF Mintz, Jessica
TI If you want to use technology to make life better for people with autism
and their families, the trick is to make the technology secondary
SO TECHNOLOGY REVIEW
LA English
DT Article
NR 0
TC 0
Z9 0
PU TECHNOL REV
PI CAMBRIDGE
PA 1 MAIN ST, 13 FLR, CAMBRIDGE, MA 02142 USA
SN 1099-274X
J9 TECHNOL REV
JI Technol. Rev.
PD SEP-OCT
PY 2013
VL 116
IS 5
BP 54
EP 56
PG 3
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 211NU
UT WOS:000323915800037
ER
PT J
AU Gramatikov, B
Irsch, K
Mullenbroich, M
Frindt, N
Qu, YH
Gutmark, R
Wu, YK
Guyton, D
AF Gramatikov, Boris
Irsch, Kristina
Muellenbroich, Marie
Frindt, Nicole
Qu, Yinhong
Gutmark, Ron
Wu, Yi-Kai
Guyton, David
TI A Device for Continuous Monitoring of True Central Fixation Based on
Foveal Birefringence
SO ANNALS OF BIOMEDICAL ENGINEERING
LA English
DT Article
DE Eye fixation; ADHD; Autism; ASD; Gaze monitor; Attention; Fatigue;
Stress; Vigilance
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; AUTISM SPECTRUM DISORDER; OCULOMOTOR ABNORMALITIES;
EYE-MOVEMENTS; CHILDREN; ADHD; INTERVENTION; PERFORMANCE; INHIBITION
AB A device for continuous monitoring of central fixation utilizes birefringence, the property of the Henle fibers surrounding the human fovea, to change the polarization state of light. A circular scan of retinal birefringence, where the scanning circle encompasses the fovea, allows identification of true central fixation-an assessment much needed in various applications in ophthalmology, psychology, and psychiatry. The device allows continuous monitoring for central fixation over an extended period of time in the presence of fixation targets and distracting stimuli, which may be helpful in detecting attention deficit hyperactivity disorder, autism spectrum disorders, and other disorders characterized by changes in the subject's ability to maintain fixation. A proof-of-concept has been obtained in a small study of ADHD patients and normal control subjects.
C1 [Gramatikov, Boris; Irsch, Kristina; Muellenbroich, Marie; Frindt, Nicole; Qu, Yinhong; Gutmark, Ron; Wu, Yi-Kai; Guyton, David] Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Div Pediat Ophthalmol & Adult Strabismus, Baltimore, MD 21287 USA.
RP Gramatikov, B (reprint author), Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Div Pediat Ophthalmol & Adult Strabismus, Wilmer 233,600 N Wolfe St, Baltimore, MD 21287 USA.
EM bgramat@jhmi.edu
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NR 41
TC 3
Z9 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-6964
J9 ANN BIOMED ENG
JI Ann. Biomed. Eng.
PD SEP
PY 2013
VL 41
IS 9
BP 1968
EP 1978
DI 10.1007/s10439-013-0818-2
PG 11
WC Engineering, Biomedical
SC Engineering
GA 209EJ
UT WOS:000323736800018
PM 23645511
ER
PT J
AU Kunkes, I
Culotta, V
Kunkes, I
Griffits, K
AF Kunkes, I
Culotta, V
Kunkes, I
Griffits, K.
TI Reading Abilities in School-Aged Children and Adolescents with High
Functioning Autism
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2013
VL 28
IS 6
BP 559
EP 559
PG 1
WC Psychology, Clinical; Psychology
SC Psychology
GA 206XR
UT WOS:000323560300118
ER
PT J
AU Lawson, R
Papadakis, A
Higginson, C
Barnett, J
Wills, M
Strang, J
Dominska, A
Wallace, G
Kenworthy, L
AF Lawson, R.
Papadakis, A.
Higginson, C.
Barnett, J.
Wills, M.
Strang, J.
Dominska, A.
Wallace, G.
Kenworthy, L.
TI Specific Executive Function Impairments Contribute to Comorbid
Psychopathology in Autism and Attention Deficit/Hyperactivity Disorder
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2013
VL 28
IS 6
BP 596
EP 597
PG 2
WC Psychology, Clinical; Psychology
SC Psychology
GA 206XR
UT WOS:000323560300212
ER
PT J
AU Stevens, S
Van Hecke, A
Carson, A
Karst, J
Schohl, K
Dolan, B
McKindles, R
Remel, R
Reveles, A
Fritz, N
McDonald, G
Wasisco, J
Kahne, J
AF Stevens, S.
Van Hecke, A.
Carson, A.
Karst, J.
Schohl, K.
Dolan, B.
McKindles, R.
Remel, R.
Reveles, A.
Fritz, N.
McDonald, G.
Wasisco, J.
Kahne, J.
TI Neural Activity Differences Between Typically Developing Adolescents and
Those with Autism Spectrum Disorders During Social Viewing Condition
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2013
VL 28
IS 6
BP 601
EP 601
PG 1
WC Psychology, Clinical; Psychology
SC Psychology
GA 206XR
UT WOS:000323560300224
ER
PT J
AU Boesch, MC
Wendt, O
Subramanian, A
Hsu, N
AF Boesch, Miriam C.
Wendt, Oliver
Subramanian, Anu
Hsu, Ning
TI Comparative Efficacy of the Picture Exchange Communication System (PECS)
versus a Speech-Generating Device: Effects on Social-communicative
Skills and Speech Development
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Autism; PECS; Speech-generating devices; AAC; Social skills; Speech
ID AUTISM SPECTRUM DISORDERS; YOUNG-CHILDREN; SINGLE-SUBJECT; DISABILITIES;
ACQUISITION; PREFERENCE; BEHAVIOR; OUTPUT; INTERVENTIONS; PRESCHOOLERS
AB The Picture Exchange Communication System (PECS) and a speech-generating device (SGD) were compared in a study with a multiple baseline, alternating treatment design. The effectiveness of these methods in increasing social-communicative behavior and natural speech production were assessed with three elementary school-aged children with severe autism who demonstrated extremely limited functional communication skills. Results for social-communicative behavior were mixed for all participants in both treatment conditions. Relatively little difference was observed between PECS and SGD conditions. Although findings were inconclusive, data patterns suggest that Phase II of the PECS training protocol is conducive to encouraging social-communicative behavior. Data for speech outcomes did not reveal any increases across participants, and no differences between treatment conditions were observed.
C1 [Boesch, Miriam C.] Univ N Texas, Denton, TX 76203 USA.
[Wendt, Oliver; Subramanian, Anu; Hsu, Ning] Purdue Univ, W Lafayette, IN 47907 USA.
RP Boesch, MC (reprint author), Univ N Texas, Dept Educ Psychol, 1155 Union Circle 311335, Denton, TX 76203 USA.
EM miriam.boesch@unt.edu
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NR 60
TC 4
Z9 4
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD SEP
PY 2013
VL 29
IS 3
BP 197
EP 209
DI 10.3109/07434618.2013.818059
PG 13
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA 205YW
UT WOS:000323481900001
PM 23952565
ER
PT J
AU Ganz, JB
Goodwyn, FD
Boles, MM
Hong, ER
Rispoli, MJ
Lund, EM
Kite, E
AF Ganz, Jennifer B.
Goodwyn, Fara D.
Boles, Margot M.
Hong, Ee Rea
Rispoli, Mandy J.
Lund, Emily M.
Kite, Elizabeth
TI Impacts of a PECS Instructional Coaching Intervention on Practitioners
and Children with Autism
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Picture Exchange Communication System (PECS); Practitioner training;
Requesting; Communication; Autism
ID EXCHANGE COMMUNICATION-SYSTEM; ALTERNATIVE COMMUNICATION; SPECTRUM
DISORDERS; YOUNG-CHILDREN; SPEECH PRODUCTION; AAC; IMPROVISATION;
PRESCHOOLERS; INDIVIDUALS; ACQUISITION
AB There is a growing research literature on the potential benefits of augmentative and alternative communication (AAC) for individuals with autism; however few studies have investigated implementation of AAC within real-life contexts. Thus, the purpose of this study was to investigate the impact of training for practitioners in implementation of aided AAC, and to examine implementation of Picture Exchange Communication System (PECS) in real-life contexts. In particular, this study involved the implementation of instructional coaching to increase opportunities offered by behavioral therapists for their preschool-aged clients to use PECS to make requests. Results indicated increases in therapist implementation of AAC and client use of AAC in trained contexts, with limited generalization to untrained contexts.
C1 [Ganz, Jennifer B.; Goodwyn, Fara D.; Boles, Margot M.; Hong, Ee Rea; Rispoli, Mandy J.; Kite, Elizabeth] Texas A&M Univ, College Stn, TX 77843 USA.
[Lund, Emily M.] Utah State Univ, Logan, UT 84322 USA.
RP Ganz, JB (reprint author), Texas A&M Univ, Dept Educ Psychol, 4225 TAMU, College Stn, TX 77843 USA.
EM jeniganz@tamu.edu
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NR 48
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD SEP
PY 2013
VL 29
IS 3
BP 210
EP 221
DI 10.3109/07434618.2013.818058
PG 12
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA 205YW
UT WOS:000323481900002
PM 23952566
ER
PT J
AU van der Meer, L
Kagohara, D
Roche, L
Sutherland, D
Balandin, S
Green, VA
O'Reilly, MF
Lancioni, GE
Marschik, PB
Sigafoos, J
AF van der Meer, Larah
Kagohara, Debora
Roche, Laura
Sutherland, Dean
Balandin, Susan
Green, Vanessa A.
O'Reilly, Mark F.
Lancioni, Giulio E.
Marschik, Peter B.
Sigafoos, Jeff
TI Teaching Multi-Step Requesting and Social Communication to Two Children
with Autism Spectrum Disorders with Three AAC Options
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Augmentative and alternative communication; Autism spectrum disorders;
Manual signing; Picture exchange; Speech-generating devices
ID SPEECH-GENERATING DEVICES; OF-THE-LITERATURE;
DEVELOPMENTAL-DISABILITIES; ALTERNATIVE COMMUNICATION; PICTURE EXCHANGE;
MANUAL SIGNS; ACQUISITION; PREFERENCE; INTERVENTIONS; INDIVIDUALS
AB The present study involved comparing the acquisition of multi-step requesting and social communication across three AAC options: manual signing (MS), picture exchange (PE), and speech-generating devices (SGDs). Preference for each option was also assessed. The participants were two children with autism spectrum disorders (ASD) who had previously been taught to use each option to request preferred items. Intervention was implemented in an alternating-treatments design. During baseline, participants demonstrated low levels of correct communicative responding. With intervention, both participants learned the target responses (two-and three-step requesting responses, greetings, answering questions, and social etiquette responses) to varying levels of proficiency with each communication option. One participant demonstrated a preference for using the SGD and the other preferred PE. The importance of examining preferences for using one AAC option over others is discussed.
C1 [van der Meer, Larah; Kagohara, Debora; Roche, Laura; Balandin, Susan; Green, Vanessa A.; Sigafoos, Jeff] Victoria Univ Wellington, Wellington 6147, New Zealand.
[Sutherland, Dean] Univ Canterbury, Christchurch 1, New Zealand.
[O'Reilly, Mark F.] Univ Texas Austin, Austin, TX 78712 USA.
[Lancioni, Giulio E.] Univ Bari, Bari, Italy.
[Marschik, Peter B.] Med Univ Graz, Graz, Austria.
RP van der Meer, L (reprint author), Victoria Univ Wellington, Sch Educ Psychol, POB 17-310, Wellington 6147, New Zealand.
EM larah.vandermeer@vuw.ac.nz
FU New Zealand Government through the Marsden Fund Council; Victoria
University of Wellington; University of Canterbury; New Zealand
Institute of Language, Brain Behaviour
FX Support for this research was provided from the New Zealand Government
through the Marsden Fund Council, administered by the Royal Society of
New Zealand; and by Victoria University of Wellington, The University of
Canterbury, and The New Zealand Institute of Language, Brain &
Behaviour.
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NR 38
TC 7
Z9 7
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD SEP
PY 2013
VL 29
IS 3
BP 222
EP 234
DI 10.3109/07434618.2013.815801
PG 13
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA 205YW
UT WOS:000323481900003
PM 23879660
ER
PT J
AU Thistle, JJ
Wilkinson, KM
AF Thistle, Jennifer J.
Wilkinson, Krista M.
TI Working Memory Demands of Aided Augmentative and Alternative
Communication for Individuals with Developmental Disabilities
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Working memory; Cognitive demands; Intellectual impairment; Aided
augmentative and alternative communication
ID DISPLAY AAC TECHNOLOGIES; SHORT-TERM-MEMORY; DOWN-SYNDROME; JOINT
ATTENTION; INTELLECTUAL DISABILITIES; CHILDREN; AUTISM; LANGUAGE;
SYMBOLS; ANIMATION
AB When speech is not functional to meet some or all of an individual's communication needs, aided augmentative and alternative communication (AAC) systems are often implemented. Although aided AAC systems offer some advantages over speech, they also impose some unique demands, especially on working memory, which is commonly defined as the cognitive system by which individuals maintain and manipulate information while completing tasks. For instance, the presence of an external aided AAC device containing arrays of symbols, not all of which are visible simultaneously, presents multiple working memory demands: individuals must maintain the target concepts in mind, all the while (a) navigating through multiple pages, (b) remembering the appropriate or most efficient navigation path, (c) locating the target symbols within the array once the host page has been located, and (d) inhibiting responses to potentially interesting distracters throughout the process. Each of these task demands involves one or more working memory operations that have been identified and studied extensively in research in the cognitive sciences. Failure to acknowledge or understand how working memory might interact with AAC use may place unintentional barriers to effective AAC interventions. This paper explores current information about working memory operations and highlights some of the most relevant issues that warrant further direct study.
C1 [Thistle, Jennifer J.; Wilkinson, Krista M.] Penn State Univ, University Pk, PA 16802 USA.
RP Thistle, JJ (reprint author), Penn State Univ, Dept Commun Sci & Disorders, 308 Ford Bldg, University Pk, PA 16802 USA.
EM jqt5124@psu.edu
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NR 66
TC 7
Z9 7
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD SEP
PY 2013
VL 29
IS 3
BP 235
EP 245
DI 10.3109/07434618.2013.815800
PG 11
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA 205YW
UT WOS:000323481900004
PM 23902430
ER
PT J
AU Alant, E
Zheng, WJ
Harty, M
Lloyd, L
AF Alant, Erna
Zheng, Wenjing
Harty, Michal
Lloyd, Lyle
TI Translucency Ratings of Blissymbols over Repeated Exposures by Children
with Autism
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Autism; Blissymbol; Translucency; Repeated exposure
ID VISUAL-SEARCH; INTELLECTUAL DISABILITIES; SPECTRUM DISORDER; TOP-DOWN;
TRANSPARENCY; ATTENTION; SYMBOLS; SYSTEM; INDIVIDUALS; INFORMATION
AB The use of graphic symbols forms an integral part of augmentative and alternative communication (AAC) strategies, particularly for pre-literate children. Although some studies have indicated that typically developing children and those with autism are able to learn symbol meanings with multiple exposures to graphic symbols, little is known about how children with autism rate the degree to which the symbol represents its referent (translucency) with repeated exposures. The purpose of this study was to describe the translucency ratings of children with autism over three consecutive exposures. Twenty-two children with autism participated in a Blissymbol translucency task that included 40 symbols. The Blissymbol task was modified from Bornman, Alant, and du Preez (2009), who explored the translucency of Blissymbols with typically developing children. Findings of this study indicated statistically significant differences in total translucency ratings of the Blissymbols by the children with autism between Day 1 and Day 3 (medium effect size) with Day 3 yielding more positive ratings than Day 1. No single Blissymbol showed statistically significant differences over the days. Findings are interpreted and further implications for research are discussed.
C1 [Alant, Erna; Zheng, Wenjing; Lloyd, Lyle] Indiana Univ, Bloomington, IN 47405 USA.
[Alant, Erna; Harty, Michal] Univ Pretoria, ZA-0002 Pretoria, South Africa.
[Zheng, Wenjing] Ludong Univ, Yantai, Peoples R China.
[Harty, Michal] Univ Cape Town, ZA-7700 Rondebosch, South Africa.
RP Alant, E (reprint author), Indiana Univ, Special Educ Program, Bloomington, IN 47405 USA.
EM ealant@gmail.com
FU Unica School for Children
FX The authors would like to thank the Unica School for Children with
Autism for their willingness to participate and support this study. Rina
Owen's assistance with the statistical analysis of this study is
acknowledged with gratitude.
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NR 49
TC 1
Z9 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD SEP
PY 2013
VL 29
IS 3
BP 272
EP 283
DI 10.3109/07434618.2013.813967
PG 12
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA 205YW
UT WOS:000323481900007
PM 23902408
ER
PT J
AU McCabe, H
AF McCabe, Helen
TI Bamboo shoots after the rain: Development and challenges of autism
intervention in China
SO AUTISM
LA English
DT Article
DE autism; China; intervention; teacher preparation; teacher training
ID REPUBLIC-OF-CHINA; CHILDREN
AB The purpose of this study was to gain an in-depth understanding of autism intervention in China, including history, progress, and current challenges. This qualitative research study included interviews with experienced professionals and observation at autism intervention organizations. Analysis of this empirical data led to three themes regarding this field. First, the development of the field can be described using the Chinese expression, mozhe shitou guohe (feeling stones to cross the river). Owing to limited exposure to outside information, methods are often created independent of research-based best practices. Second, autism intervention in China has had a strong, and until recently, almost exclusive, focus on young children. Finally, there are continued challenges to providing effective services that relate to the desires of parents and professionals to provide more'; a focus on quantity may be preventing a focus on quality. The article concludes with an analysis of the findings and practical implications that may be used by practitioners or scholars planning to do work in China.
C1 [McCabe, Helen] Hobart & William Smith Coll, Geneva, NY 14456 USA.
RP McCabe, H (reprint author), Hobart & William Smith Coll, Dept Educ, Geneva, NY 14456 USA.
EM mccabe@hws.edu
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NR 44
TC 2
Z9 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2013
VL 17
IS 5
BP 510
EP 526
DI 10.1177/1362361312436849
PG 17
WC Psychology, Developmental
SC Psychology
GA 207ZW
UT WOS:000323644900002
PM 23144167
ER
PT J
AU Turner-Brown, LM
Baranek, GT
Reznick, JS
Watson, LR
Crais, ER
AF Turner-Brown, Lauren M.
Baranek, Grace T.
Reznick, J. Steven
Watson, Linda R.
Crais, Elizabeth R.
TI The First Year Inventory: a longitudinal follow-up of 12-month-old to
3-year-old children
SO AUTISM
LA English
DT Article
DE autism screening; First Year Inventory; sensory-regulatory;
social-communication
ID AUTISM SPECTRUM DISORDERS; PERVASIVE DEVELOPMENTAL DISORDERS; TRAITS
QUESTIONNAIRE ESAT; MODIFIED CHECKLIST; DIAGNOSIS; AGE; TODDLERS;
INFANTS; INSTRUMENT; SIGNS
AB The First Year Inventory is a parent-report measure designed to identify 12-month-old infants at risk for autism spectrum disorder. First Year Inventory taps behaviors that indicate risk in the developmental domains of sensory-regulatory and social-communication functioning. This longitudinal study is a follow-up of 699 children at 3 years of age from a community sample whose parents completed the First Year Inventory when their children were 12 months old. Parents of all 699 children completed the Social Responsiveness Scale-Preschool version and the Developmental Concerns Questionnaire to determine age 3 developmental outcomes. In addition, children deemed at risk for autism spectrum disorder based on liberal cut points on the First Year Inventory, Social Responsiveness Scale-Preschool, and/or Developmental Concerns Questionnaire were invited for in-person diagnostic evaluations. We found 9 children who had a confirmed diagnosis of autism spectrum disorder from the sample of 699. Receiver operating characteristic analyses determined that a two-domain cutoff score yielded optimal classification of children: 31% of those meeting algorithm cutoffs had autism spectrum disorder and 85% had a developmental disability or concern by age 3. These results suggest that the First Year Inventory is a promising tool for identifying 12-month-old infants who are at risk for an eventual diagnosis of autism spectrum disorder.
C1 [Turner-Brown, Lauren M.; Baranek, Grace T.; Reznick, J. Steven; Watson, Linda R.; Crais, Elizabeth R.] Univ N Carolina, Chapel Hill, NC 27599 USA.
RP Turner-Brown, LM (reprint author), Univ N Carolina, Carolina Inst Dev Disabil, Campus Box 7255, Chapel Hill, NC 27599 USA.
EM lauren.brown@CIDD.unc.edu
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Baranek GT, 2003, 1 YEAR INVENTORY FYI
Centers for Disease Control, 2009, MMWR-MORBID MORTAL W, V58, P1
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NR 42
TC 8
Z9 8
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2013
VL 17
IS 5
BP 527
EP 540
DI 10.1177/1362361312439633
PG 14
WC Psychology, Developmental
SC Psychology
GA 207ZW
UT WOS:000323644900003
PM 22781058
ER
PT J
AU Mak-Fan, KM
Morris, D
Vidal, J
Anagnostou, E
Roberts, W
Taylor, MJ
AF Mak-Fan, Kathleen M.
Morris, Drew
Vidal, Julie
Anagnostou, Evdokia
Roberts, Wendy
Taylor, Margot J.
TI White matter and development in children with an autism spectrum
disorder
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; brain structure; development; white matter;
diffusion tensor imaging; diffusivity
ID VOXEL-BASED MORPHOMETRY; DIFFUSION TENSOR; ASPERGER-SYNDROME;
CORPUS-CALLOSUM; BRAIN VOLUME; SPIN-ECHO; ADULTS; MRI; ABNORMALITIES;
CONNECTIVITY
AB Recent research suggests that brain development follows an abnormal trajectory in children with autism spectrum disorders (ASD). The current study examined changes in diffusivity with age within defined white matter tracts in a group of typically developing children and a group of children with an ASD, aged 6 to 14 years. Age by group interactions were observed for frontal, long distant, interhemispheric and posterior tracts, for longitudinal, radial and mean diffusivity, but not for fractional anisotropy. In all cases, these measures of diffusivity decreased with age in the typically developing group, but showed little or no change in the ASD group. This supports the hypothesis of an abnormal developmental trajectory of white matter in this population, which could have profound effects on the development of neural connectivity and contribute to atypical cognitive development in children with ASD.
C1 [Mak-Fan, Kathleen M.; Taylor, Margot J.] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada.
[Mak-Fan, Kathleen M.; Morris, Drew; Vidal, Julie; Taylor, Margot J.] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
[Anagnostou, Evdokia] Bloorview Kids Rehab, Toronto, ON, Canada.
[Anagnostou, Evdokia; Roberts, Wendy] Univ Toronto, Dept Pediat, Toronto, ON, Canada.
[Taylor, Margot J.] Hosp Sick Children, NMH Res Inst, Toronto, ON M5G 1X8, Canada.
RP Mak-Fan, KM (reprint author), Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM katie@psych.utoronto.ca
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NR 56
TC 11
Z9 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2013
VL 17
IS 5
BP 541
EP 557
DI 10.1177/1362361312442596
PG 17
WC Psychology, Developmental
SC Psychology
GA 207ZW
UT WOS:000323644900004
PM 22700988
ER
PT J
AU Malesa, E
Foss-Feig, J
Yoder, P
Warren, Z
Walden, T
Stone, WL
AF Malesa, Elizabeth
Foss-Feig, Jennifer
Yoder, Paul
Warren, Zachary
Walden, Tedra
Stone, Wendy L.
TI Predicting language and social outcomes at age 5 for later-born siblings
of children with autism spectrum disorders
SO AUTISM
LA English
DT Article
DE joint attention; social skills; language; longitudinal; younger siblings
of children with ASD
ID INFANT JOINT ATTENTION; 2-YEAR-OLDS STAT; SCREENING TOOL; RISK;
COGNITION; BEHAVIOR; SKILL; TWIN
AB The relation between early joint attention (in which a child coordinates attention between another person and an object or event) and later language and social outcomes was examined in younger siblings of children with autism spectrum disorder (Sibs-ASD) and younger siblings of children with typical development (Sibs-TD). Initial levels of joint attention (at a mean age of 15 months) as well as growth in levels of joint attention (between 15 months and 34 months) were used as potential predictors of outcomes at age 5. The results revealed that initial levels of initiating joint attention (IJA) were associated with language skills at outcome. In addition, growth of responding to joint attention (RJA) was associated with social skills at age 5. These patterns of associations were not significantly different between the Sibs-TD and Sibs-ASD groups. Although the Sibs-ASD group had lower joint attention scores than the Sibs-TD group at younger ages, significant group differences were not found for most measures at age 5.
C1 [Malesa, Elizabeth; Foss-Feig, Jennifer; Yoder, Paul; Warren, Zachary; Walden, Tedra] Vanderbilt Univ, Nashville, TN USA.
[Stone, Wendy L.] Univ Washington, Seattle, WA 98195 USA.
RP Stone, WL (reprint author), Univ Washington, Autism Ctr, CHDD Box 357920,1701 NE Columbia Rd 385, Seattle, WA 98195 USA.
EM stonew@uw.edu
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NR 43
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2013
VL 17
IS 5
BP 558
EP 570
DI 10.1177/1362361312444628
PG 13
WC Psychology, Developmental
SC Psychology
GA 207ZW
UT WOS:000323644900005
PM 22751752
ER
PT J
AU Freeth, M
Bullock, T
Milne, E
AF Freeth, Megan
Bullock, Tom
Milne, Elizabeth
TI The distribution of and relationship between autistic traits and social
anxiety in a UK student population
SO AUTISM
LA English
DT Article
DE social anxiety; autistic traits; population screening; prevalence;
gender
ID SPECTRUM QUOTIENT AQ; PSYCHIATRIC-SYMPTOMS; ASPERGER-SYNDROME;
YOUNG-ADULTS; SAMPLE; PHOBIA; ADOLESCENTS; PREVALENCE; DISORDERS;
MORBIDITY
AB Traits associated with autism and social anxiety were assessed in a UK student population (n = 1325) using the Autism-spectrum Quotient and the Liebowitz Social Anxiety Scale. Clinically relevant levels of autistic traits were observed in 3.3% of the cohort; 10.1% of the cohort reported clinically relevant levels of social anxiety; 1.8% of the cohort met clinically relevant cut-offs for both conditions. There was a significant positive correlation between scores on the two scales (r = .51); students with high levels of autistic traits were more likely to report increased social anxiety than those with average or low levels of autistic traits. Level of social anxiety was best predicted by autistic traits associated with social skill, attention switching and communication, accounting for 33% of the variance in social anxiety scores. Social skill was a better predictor of social anxiety in males than females; attention switching ability was a better predictor of social anxiety in females than males. Students with high levels of autistic traits displayed heightened anxiety to situations and activities necessary for the successful completion of their degree. Implications for student well-being and attainment are discussed.
C1 [Freeth, Megan; Bullock, Tom; Milne, Elizabeth] Univ Sheffield, Dept Psychol, Sheffield S10 2TP, S Yorkshire, England.
RP Freeth, M (reprint author), Univ Sheffield, Dept Psychol, Western Bank, Sheffield S10 2TP, S Yorkshire, England.
EM m.freeth@sheffield.ac.uk
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White SW, 2011, AUTISM, V15, P683, DOI 10.1177/1362361310393363
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Wittchen HU, 1999, PSYCHOL MED, V29, P309, DOI 10.1017/S0033291798008174
NR 35
TC 3
Z9 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2013
VL 17
IS 5
BP 571
EP 581
DI 10.1177/1362361312445511
PG 11
WC Psychology, Developmental
SC Psychology
GA 207ZW
UT WOS:000323644900006
PM 22987896
ER
PT J
AU Dykstra, JR
Sabatos-DeVito, MG
Irvin, DW
Boyd, BA
Hume, KA
Odom, SL
AF Dykstra, Jessica R.
Sabatos-DeVito, Maura G.
Irvin, Dwight W.
Boyd, Brian A.
Hume, Kara A.
Odom, Sam L.
TI Using the Language Environment Analysis (LENA) system in preschool
classrooms with children with autism spectrum disorders
SO AUTISM
LA English
DT Article
DE autism spectrum disorders; preschool; language; natural environment;
LENA system
ID YOUNG-CHILDREN; INTENTIONAL COMMUNICATION; QUALITY; RESPONSIVITY;
TODDLERS; OUTCOMES; INFANT
AB This study describes the language environment of preschool programs serving children with autism spectrum disorders (ASDs) and examines relationships between child characteristics and an automated measure of adult and child language in the classroom. The Language Environment Analysis (LENA) system was used with 40 children with ASD to collect data on adult and child language. Standardized assessments were administered to obtain language, cognitive, and autism severity scores for participants. With a mean of over 5 hours of recording across two days several months apart, there was a mean of 3.6 child vocalizations per minute, 1.0 conversational turns (in which either the adult or child respond to the other within 5 seconds) per minute, and 29.2 adult words per minute. Two of the three LENA variables were significantly correlated with language age-equivalents. Cognitive age-equivalents were also significantly correlated with two LENA variables. Autism Diagnostic Observation Schedule severity scores and LENA variables were not significantly correlated. Implications for using the LENA system with children with ASD in the school environment are discussed.
C1 [Dykstra, Jessica R.] Univ N Carolina, Div Speech & Hearing Sci, Chapel Hill, NC 27599 USA.
[Sabatos-DeVito, Maura G.] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA.
[Irvin, Dwight W.] Univ N Carolina, Dept Educ, Chapel Hill, NC 27599 USA.
[Boyd, Brian A.] Univ N Carolina, Div Occupat Sci & Occupat Therapy, Chapel Hill, NC 27599 USA.
[Hume, Kara A.; Odom, Sam L.] Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC 27599 USA.
RP Dykstra, JR (reprint author), Univ N Carolina, Div Speech & Hearing Sci, 321 S Columbia St CB 7190, Chapel Hill, NC 27599 USA.
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Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276
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NR 36
TC 4
Z9 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2013
VL 17
IS 5
BP 582
EP 594
DI 10.1177/1362361312446206
PG 13
WC Psychology, Developmental
SC Psychology
GA 207ZW
UT WOS:000323644900007
PM 22751753
ER
PT J
AU So, P
Greaves-Lord, K
van der Ende, J
Verhulst, FC
Rescorla, L
de Nijs, PFA
AF So, Pety
Greaves-Lord, Kirstin
van der Ende, Jan
Verhulst, Frank C.
Rescorla, Leslie
de Nijs, Pieter F. A.
TI Using the Child Behavior Checklist and the Teacher's Report Form for
identification of children with autism spectrum disorders
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; Child Behavior Checklist; screening; Teacher's
Report Form
ID SCREENING QUESTIONNAIRE; ASPERGER-SYNDROME; SOCIETIES; PARENT; CBCL
AB This study evaluated the ability of the Child Behavior Checklist and the Teacher's Report Form to identify children with autism spectrum disorders (ASD), using a sample of children with ASD (n = 458), referred children without ASD (n = 1109) and children from the general population (n = 999). A ten items ASD scale was constructed using half of the sample and the ability of this scale to discriminate between children with ASD and the other children was tested for the CBCL and the TRF separately and together in the other half of the sample. Using a cut-off score of 8 the combined CBCL/TRF ASD scale demonstrated high predictive values (NPV 95%, PPV 73%) in identifying children with ASD and children in the general population sample. This might be an acceptable percentage of false positives in general screening, considering the chance that these children might have other behavioural, emotional, and developmental problems which also need psychiatric evaluation. In the referred population, using a cut-off of 13, PPV was 49% and NPV was 85%. The high NPV indicates that in a referred population the scale is especially good at identifying children who do not need evaluation with a more ASD-specific instrument.
C1 [Greaves-Lord, Kirstin; van der Ende, Jan; Verhulst, Frank C.; de Nijs, Pieter F. A.] Sophia Childrens Univ Hosp, Erasmus Med Ctr Rotterdam, NL-3015 GJ Rotterdam, Netherlands.
[Rescorla, Leslie] Bryn Mawr Coll, Bryn Mawr, PA 19010 USA.
RP de Nijs, PFA (reprint author), Sophia Childrens Univ Hosp, Dept Child & Adolescent Psychiat, Erasmus Med Ctr Rotterdam, Dr Molewaterpl 60, NL-3015 GJ Rotterdam, Netherlands.
EM p.denijs@erasmusmc.nl
CR Achenbach T, 2000, CHILD BEHAV CHECKLIS
Achenbach TM, 2001, MANUAL ASEBA SCH AGE
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444
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Brown NW, 1993, TESTING STRUCTURAL E
CDC U. S. Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1
Constantino JN, 2005, SOCIAL RESPONSIVENES
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Field A., 2009, DISCOVERING STAT USI
Hartley SL, 2009, J AUTISM DEV DISORD, V39, P1715, DOI 10.1007/s10803-009-0810-8
Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
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Ivanova MY, 2007, J CLIN CHILD ADOLESC, V36, P405
Kanne SM, 2009, J AUTISM DEV DISORD, V39, P856, DOI 10.1007/s10803-009-0694-7
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Murray DS, 2009, LANG SPEECH HEAR SER, V40, P109, DOI 10.1044/0161-1461(2008/07-0089)
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Rescorla LA, 2007, SCHOOL PSYCHOL REV, V36, P91
Rutter M., 2003, ADI R AUTISM DIAGNOS
Sikora DM, 2008, J AUTISM DEV DISORD, V38, P440, DOI 10.1007/s10803-007-0407-z
Tick NT, 2007, ACTA PSYCHIAT SCAND, V116, P473, DOI 10.1111/j.1600-0447.2007.01068.x
Verhulst F. C., 1997, MANUAL TEACHERS REPO
NR 29
TC 2
Z9 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2013
VL 17
IS 5
BP 595
EP 607
DI 10.1177/1362361312448855
PG 13
WC Psychology, Developmental
SC Psychology
GA 207ZW
UT WOS:000323644900008
PM 22914776
ER
PT J
AU Ben-Sasson, A
Lamash, L
Gal, E
AF Ben-Sasson, Ayelet
Lamash, Liron
Gal, Eynat
TI To enforce or not to enforce? The use of collaborative interfaces to
promote social skills in children with high functioning autism spectrum
disorder
SO AUTISM
LA English
DT Article
DE Technology; Children; High Functioning Autism Spectrum Disorders; Social
Intervention; Social Interaction
ID COMMUNICATION; ADOLESCENTS; FRIENDSHIP; DEFICITS; PEOPLE
AB The goal of this stud was to examine whether a technological touch activated Collaborative Puzzle Game (CPG) increased positive social behaviors in children with high functioning autism spectrum disorder (HFASD). The CPG involved construction of a virtual puzzle by selecting and dragging pieces into the solution area on a touch screen table. The target picture was presented on the top of the screen. Six dyads of children with HFASD (aged 8-11 years) engaged in the CPG in a Free Play (FP) mode in which partners could independently move puzzle pieces versus in an Enforced Collaboration (EC) mode in which partners could only move puzzle pieces together. Videos of the dames were coded for the frequencies of positive and negative social interaction, affect, play, and autistic behaviors. Parents completed the Social Responsiveness Scale (SRS). Wilcoxon Signed-ranks tests indicated that children with HFASD showed significantly higher frequencies of positive social interaction and collaborative play in the EC versus FP modes but there were no differences in negative social behaviors. Differences in social behaviors between partners during the puzzle games were not significant; however there were differences within pair in the severity of social deficits as assessed by the SRS questionnaire. The CPG in an EC mode was effective in promoting positive social interaction by requiring children to work together towards a mutual goal. However, the increased challenge in this mode, particularly for children with lower social-communication skills, suggests the need for establishing selection criteria and mediation steps for such interventions.
C1 [Ben-Sasson, Ayelet; Lamash, Liron; Gal, Eynat] Univ Haifa, IL-31905 Haifa, Israel.
RP Ben-Sasson, A (reprint author), Univ Haifa, Dept Occupat Therapy, IL-31905 Haifa, Israel.
EM asasson@univ.haifa.ac.il
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Asher S. R., 1990, PEER REJECTION CHILD, P253
Battocchi A, 2009, J ASSISTIVE TECHNOLO, V4, P4
Bauminger N, 2008, J AUTISM DEV DISORD, V38, P1211, DOI 10.1007/s10803-007-0501-2
Bauminger N, 2008, J ABNORM CHILD PSYCH, V36, P135, DOI 10.1007/s10802-007-9156-x
Bauminger N, 2003, J AUTISM DEV DISORD, V33, P489, DOI 10.1023/A:1025827427901
Bauminger N., 2005, FRIENDSHIP OBS UNPUB
Bernard-Opitz V, 2001, J AUTISM DEV DISORD, V31, P377, DOI 10.1023/A:1010660502130
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Cappelletti A, P INT C ADV LEARN TE
Charles J, 2005, NEURAL PLAST, V12, P2
Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x
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Constantino JN, 2005, SOCIAL RESPONSIVENES
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DAWSON G, 1990, J ABNORM CHILD PSYCH, V18, P335, DOI 10.1007/BF00916569
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Gal E, 2005, LECT NOTES COMPUT SC, V3814, P320
Gal E, 2011, ISRAELI J OCCUPATION, V20, pH75
Grynszpan O, 2005, ASSIST TECHN RES SER, V16, P456
Kenny D. A., 2006, ANAL DYADIC DATA
Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947
Murray D, 1997, AUTISM LEARNING GUID, P100
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Piper A. M., 2006, P 2006 20 ANN C COMP
Scheeren AM, 2012, J AUTISM DEV DISORD, V42, P2046, DOI 10.1007/s10803-012-1451-x
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Zancanaro M, 2011, CHI C HUM FACT COMP
NR 39
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2013
VL 17
IS 5
BP 608
EP 622
DI 10.1177/1362361312451526
PG 15
WC Psychology, Developmental
SC Psychology
GA 207ZW
UT WOS:000323644900009
PM 22987887
ER
PT J
AU Wiggins, LD
Robins, DL
Yeargin-Allsopp, M
AF Wiggins, Lisa D.
Robins, Diana L.
Yeargin-Allsopp, Marshalyn
TI Short report: Improving record-review surveillance of young children
with an autism spectrum disorder
SO AUTISM
LA English
DT Review
DE autism spectrum disorder; early identification; surveillance
ID PERVASIVE DEVELOPMENTAL DISORDERS
AB Introduction:
Records-based autism spectrum disorder surveillance developed at the Centers for Disease Control and Prevention has been extended to younger cohorts, although the utility of additional record sources has not been examined. We therefore conducted a pilot project to describe whether Centers for Disease Control and Prevention surveillance could identify younger children with an autism spectrum disorder evaluated as part of an ongoing screening study at Georgia State University.
Methods:
In all, 31 families of children who screened positive for autism spectrum disorder and received a clinical evaluation at Georgia State University agreed to participate in the project. Of these, 10 children lived inside the surveillance area and had records abstracted and reviewed for this project. Centers for Disease Control and Prevention surveillance results (i.e. autism spectrum disorder or non-autism spectrum disorder) were compared with Georgia State University evaluation results (i.e. autism spectrum disorder or non-autism spectrum disorder).
Results:
In all, 4 of the 10 children were diagnosed with an autism spectrum disorder after the Georgia State University evaluation. None of the 4 children with an autism spectrum disorder were identified by current Centers for Disease Control and Prevention surveillance methods but all 4 children were identified by Centers for Disease Control and Prevention surveillance methods when additional record sources were included (i.e. records from the statewide early intervention program and Georgia State University evaluation).
Conclusion:
These findings suggest that partnering with early intervention programs and encouraging early autism spectrum disorder screening might improve autism spectrum disorder surveillance among young children.
C1 [Wiggins, Lisa D.; Yeargin-Allsopp, Marshalyn] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Robins, Diana L.] Georgia State Univ, Atlanta, GA 30303 USA.
RP Wiggins, LD (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA.
EM lwiggins@cdc.gov
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1
Lord C., 1999, AUTISM DIAGNOSTIC OB
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
Mullen E, 1995, MULLEN SCALES EARLY
Nicholas JS, 2009, ANN EPIDEMIOL, V19, P808, DOI 10.1016/j.annepidem.2009.04.005
Nonkin-Avchen R, 2011, J AUTISM DEV DISORD, V41, P227, DOI 10.1007/s10803-010-1050-7
Robins D., 1999, MODIFIED CHECKLIST A
Robins DL, 1999, FOLLOW UP INTERVIEW
Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569
Schopler E., 1988, CHILDHOOD AUTISM RAT
Sparrow SS, 2005, VINELAND ADAPTIVE BE
Van Naarden Braun K, 2002, MMWR SURVEILL SUMM, V56, P29
Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49
NR 15
TC 1
Z9 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
J9 AUTISM
JI Autism
PD SEP
PY 2013
VL 17
IS 5
BP 623
EP 629
DI 10.1177/1362361312452161
PG 7
WC Psychology, Developmental
SC Psychology
GA 207ZW
UT WOS:000323644900010
PM 22987886
ER
PT J
AU Woodruff, CC
Klein, S
AF Woodruff, C. Chad
Klein, Shelley
TI Attentional distraction, mu-suppression and empathic perspective-taking
SO EXPERIMENTAL BRAIN RESEARCH
LA English
DT Article
DE mu-suppression; Empathy; Automaticity; Electroencephalography
ID VISUAL MENTAL-IMAGERY; MIRROR NEURON SYSTEM; AUTISM; PERCEPTION;
EXECUTION; REPRESENTATIONS; ACTIVATION; GENERATION; PICTURES; AREAS
AB Social mirroring has been proposed to be an automatic process whereby an observer understands the intentions of others by using his/her motor system to simulate others' actions. Automaticity implies that if the observer's eyes are fixed on another person, the observer's mirror system will engage whether attention is focused on the other person or not. This proposal has not been fully tested, however. The current study therefore addressed whether mu-suppression, an electroencephalographic measure of putative mirror neuron activity, induced by observing the actions of others would be affected by attentional distraction. Participants performed two different distraction tasks while watching a video of a hand repeatedly touching the forefinger and thumb together. mu-suppression was compared across three different blocks: (1) video with no distraction, (2) video with mental imagery distraction and (3) video with word generation distraction. While the no distraction condition yielded the typical level of mu-suppression, the word generation distraction task eliminated any evidence of mu-suppression suggesting that simply fixating the eyes on an action without focusing attention is insufficient to induce mu-suppression. A secondary goal of the current experiment was to replicate correlational findings between mu-suppression and empathic perspective-taking. A counterintuitive, negative relationship between mu-suppression and perspective-taking was replicated, and a theoretical model for explaining this relationship is offered.
C1 [Woodruff, C. Chad; Klein, Shelley] No Arizona Univ, Dept Psychol, Flagstaff, AZ 86011 USA.
RP Woodruff, CC (reprint author), No Arizona Univ, Dept Psychol, Flagstaff, AZ 86011 USA.
EM chad.woodruff@nau.edu
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NR 40
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4819
J9 EXP BRAIN RES
JI Exp. Brain Res.
PD SEP
PY 2013
VL 229
IS 4
BP 507
EP 515
DI 10.1007/s00221-013-3612-3
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA 208FL
UT WOS:000323662600001
PM 23807476
ER
PT J
AU Elwin, M
Ek, L
Kjellin, L
Schroder, A
AF Elwin, Marie
Ek, Lena
Kjellin, Lars
Schroder, Agneta
TI Too much or too little: Hyper- and hypo-reactivity in high-functioning
autism spectrum conditions
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE Autism spectrum disorder; sensory reactivity; qualitative research
ID ASPERGER-SYNDROME; DEVELOPMENTAL DISORDERS; CHILDREN; ADULTS;
ABNORMALITIES; COMORBIDITY; EXPERIENCES; ACCOUNTS; SAMPLE
AB Background Sensory reactivity in people with autism spectrum conditions (ASC) has been found to differ in comparison to reactivity in people without ASC. In this study sensory experiences of high-functioning individuals with ASC were explored and described.
Method Interview data from 15 participants with a diagnosis of ASC were analysed by content analysis.
Results Seven aspects of sensory experiences were identified: Being hyper- and hypo-reactive, reacting to general overload, having strong stimuli preferences, managing attentiveness to stimuli, managing sensory/motor stimuli, and dealing with consequences of sensory reactions in daily life.
Conclusions The categorisation of sensory reactivity in this study can guide clinicians on how to pose questions about sensory issues to individuals with ASC. The assessment of spectrum-specific sensory experiences in high-functioning ASC and their association with other social and nonsocial features of ASC are goals for further research.
C1 [Elwin, Marie; Kjellin, Lars; Schroder, Agneta] Orebro Cty Council, Psychiat Res Ctr, Orebro, Sweden.
[Elwin, Marie; Kjellin, Lars] Univ Orebro, Sch Hlth & Med Sci, Orebro, Sweden.
[Ek, Lena] Blekinge Hosp, Dept Psychogeriatr, Karlskrona, Sweden.
RP Elwin, M (reprint author), Orebro Univ Hosp, Psychiat Res Ctr, POB 1613, S-70116 Orebro, Sweden.
EM marie.elvin@orebroll.se
CR American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
(APA) APA, 2000, DIAGN STAT MAN MENT
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World Medical Association Declaration of Helsinki, 2008, ETH PRINC MED RES IN
NR 39
TC 2
Z9 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1366-8250
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD SEP
PY 2013
VL 38
IS 3
BP 232
EP 241
DI 10.3109/13668250.2013.815694
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 209BU
UT WOS:000323729700005
PM 23984882
ER
PT J
AU Rodriguez, NM
Thompson, RH
Stocco, CS
Schlichenmeyer, K
AF Rodriguez, Nicole M.
Thompson, Rachel H.
Stocco, Corey S.
Schlichenmeyer, Kevin
TI Arranging and ordering in autism spectrum disorder: Characteristics,
severity, and environmental correlates
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE Arranging and ordering; autism spectrum disorder; compulsive behaviour;
higher level restricted and repetitive behaviour
ID FUNCTIONAL-ANALYSIS; REPETITIVE BEHAVIORS; DESCRIPTIVE ANALYSIS;
FEATURES; CHILDREN
AB Background There is a need for a more accurate characterisation of higher level restricted and repetitive behaviour (RRB) in autism spectrum disorder (ASD), including why it might be considered problematic and events associated with its occurrence.
Method We selected one form of higher level RRB-arranging and ordering-that was rated as severe for a large percentage of the population sampled. We interviewed 20 students' teachers and conducted naturalistic observations for 15 of those students.
Results The characteristics of arranging and ordering varied across, and sometimes within, individuals. Problems associated with compulsive-like(1) behaviour also varied, with several unanticipated reported problems. With the exception of attention, social consequences were relatively infrequent.
Conclusions These data highlight the need for research on the assessment and treatment of arranging and ordering and clinical attention to compulsive-like behaviour in ASD. Interviews and naturalistic observations are useful for structuring additional observations and analyses.
C1 [Rodriguez, Nicole M.] Univ Nebraska Med Ctr, Munroe Meyer Inst, Omaha, NE USA.
[Thompson, Rachel H.; Stocco, Corey S.; Schlichenmeyer, Kevin] Western New England Univ, Springfield, MA USA.
RP Rodriguez, NM (reprint author), 985450 Nebraska Med Ctr, Munroe Meyer Inst, Omaha, NE 68198 USA.
EM nicole.rodriguez@unmc.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 32
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1366-8250
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD SEP
PY 2013
VL 38
IS 3
BP 242
EP 255
DI 10.3109/13668250.2013.812192
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 209BU
UT WOS:000323729700006
PM 23984883
ER
PT J
AU Eran, A
Li, JB
Vatalaro, K
McCarthy, J
Rahimov, F
Collins, C
Markianos, K
Margulies, DM
Brown, EN
Calvo, SE
Kohane, IS
Kunkel, LM
AF Eran, A.
Li, J. B.
Vatalaro, K.
McCarthy, J.
Rahimov, F.
Collins, C.
Markianos, K.
Margulies, D. M.
Brown, E. N.
Calvo, S. E.
Kohane, I. S.
Kunkel, L. M.
TI Comparative RNA editing in autistic and neurotypical cerebella
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE A-to-I; autism; epigenetics; human cerebellum; neurodevelopment; RNA
editing
ID PRE-MESSENGER-RNA; SPECTRUM DISORDERS; PREFRONTAL CORTEX; RECEPTOR
CHANNELS; BRAIN-DEVELOPMENT; ADAR DEAMINASES; ENZYME ADAR2; ADENOSINE;
TRANSCRIPTOME; MODULATION
AB Adenosine-to-inosine (A-to-I) RNA editing is a neurodevelopmentally regulated epigenetic modification shown to modulate complex behavior in animals. Little is known about human A-to-I editing, but it is thought to constitute one of many molecular mechanisms connecting environmental stimuli and behavioral outputs. Thus, comprehensive exploration of A-to-I RNA editing in human brains may shed light on gene-environment interactions underlying complex behavior in health and disease. Synaptic function is a main target of A-to-I editing, which can selectively recode key amino acids in synaptic genes, directly altering synaptic strength and duration in response to environmental signals. Here, we performed a high-resolution survey of synaptic A-to-I RNA editing in a human population, and examined how it varies in autism, a neurodevelopmental disorder in which synaptic abnormalities are a common finding. Using ultra-deep (>1000 x) sequencing, we quantified the levels of A-to-I editing of 10 synaptic genes in postmortem cerebella from 14 neurotypical and 11 autistic individuals. A high dynamic range of editing levels was detected across individuals and editing sites, from 99.6% to below detection limits. In most sites, the extreme ends of the population editing distributions were individuals with autism. Editing was correlated with isoform usage, clusters of correlated sites were identified, and differential editing patterns examined. Finally, a dysfunctional form of the editing enzyme adenosine deaminase acting on RNA B1 was found more commonly in postmortem cerebella from individuals with autism. These results provide a population-level, high-resolution view of A-to-I RNA editing in human cerebella and suggest that A-to-I editing of synaptic genes may be informative for assessing the epigenetic risk for autism.
C1 [Eran, A.; Brown, E. N.; Kohane, I. S.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
[Eran, A.; Vatalaro, K.; McCarthy, J.; Rahimov, F.; Collins, C.; Markianos, K.; Kunkel, L. M.] Boston Childrens Hosp, Program Genom, Boston, MA 02115 USA.
[Li, J. B.] Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
[Rahimov, F.; Collins, C.; Kunkel, L. M.] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.
[Markianos, K.; Margulies, D. M.; Kohane, I. S.; Kunkel, L. M.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA.
[Margulies, D. M.] Correlagen Diagnost, Waltham, MA USA.
[Margulies, D. M.; Kohane, I. S.] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA USA.
[Brown, E. N.] Harvard Univ, Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Neurosci Stat Res Lab,Med Sch, Boston, MA USA.
[Brown, E. N.] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Calvo, S. E.] Broad Inst Harvard & MIT, Cambridge, MA USA.
[Kunkel, L. M.] Manton Ctr Orphan Dis Res, Boston, MA USA.
RP Kohane, IS (reprint author), Boston Childrens Hosp, Dept Pediat, 300 Longwood Ave,Enders 144, Boston, MA 02115 USA.
EM Isaac_kohane@harvard.edu; kunkel@enders.tch.harvard.edu
FU National Institute of Child Health and Human Development Brain and
Tissue Bank for Developmental Disorders at the University of Maryland,
Baltimore, MD, USA [HHSN275200900011C, N01-HD-9-0011]; NIH
[1R01MH085143-01]; [MH068855]; [NIH-P30-HD18655]
FX We thank Oliver St Lawrence, Jamie Jett, Benjamin Boese and Tim Harkins
at 454, our wonderful lab mates, Professor David Bartel, Thutrang
Nguyen, Eran Mick and Elena Helman for their tremendous help. Human
tissue was obtained from the National Institute of Child Health and
Human Development Brain and Tissue Bank for Developmental Disorders at
the University of Maryland, Baltimore, MD, USA contract
HHSN275200900011C, re. no. N01-HD-9-0011, and from The Harvard Brain
Tissue Resource Center, through the Autism Tissue Program. The Harvard
Brain Tissue Resource Center is supported by grant MH068855. The
Molecular Genetics Core Facility at Children's Hospital Boston
Intellectual and Developmental Disabilities Research Center (IDDRC) is
supported by grant NIH-P30-HD18655. This study was generously supported
by the Nancy Lurie Marks Family Foundation, The Roche Applied Science
Sequencing Grant Program, Autism Speaks, Simons Foundation and the NIH
Grant 1R01MH085143-01.
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NR 74
TC 4
Z9 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD SEP
PY 2013
VL 18
IS 9
BP 1041
EP 1048
DI 10.1038/mp.2012.118
PG 8
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 207JS
UT WOS:000323595300015
PM 22869036
ER
PT J
AU Lee, SH
Ripke, S
Neale, BM
Faraone, SV
Purcell, SM
Perlis, RH
Mowry, BJ
Thapar, A
Goddard, ME
Witte, JS
Absher, D
Agartz, I
Akil, H
Amin, F
Andreassen, OA
Anjorin, A
Anney, R
Anttila, V
Arking, DE
Asherson, P
Azevedo, MH
Backlund, L
Badner, JA
Bailey, AJ
Banaschewski, T
Barchas, JD
Barnes, MR
Barrett, TB
Bass, N
Battaglia, A
Bauer, M
Bayes, M
Bellivier, F
Bergen, SE
Berrettini, W
Betancur, C
Bettecken, T
Biederman, J
Binder, EB
Black, DW
Blackwood, DHR
Bloss, CS
Boehnke, M
Boomsma, DI
Breen, G
Breuer, R
Bruggeman, R
Cormican, P
Buccola, NG
Buitelaar, JK
Bunney, WE
Buxbaum, JD
Byerley, WF
Byrne, EM
Caesar, S
Cahn, W
Cantor, RM
Casas, M
Chakravarti, A
Chambert, K
Choudhury, K
Cichon, S
Cloninger, CR
Collier, DA
Cook, EH
Coon, H
Cormand, B
Corvin, A
Coryell, WH
Craig, DW
Craig, IW
Crosbie, J
Cuccaro, ML
Curtis, D
Czamara, D
Datta, S
Dawson, G
Day, R
De Geus, EJ
Degenhardt, F
Djurovic, S
Donohoe, GJ
Doyle, AE
Duan, JB
Dudbridge, F
Duketis, E
Ebstein, RP
Edenberg, HJ
Elia, J
Ennis, S
Etain, B
Fanous, A
Farmer, AE
Ferrier, IN
Flickinger, M
Fombonne, E
Foroud, T
Frank, J
Franke, B
Fraser, C
Freedman, R
Freimer, NB
Freitag, CM
Friedl, M
Frisen, L
Gallagher, L
Gejman, PV
Georgieva, L
Gershon, ES
Geschwind, DH
Giegling, I
Gill, M
Gordon, SD
Gordon-Smith, K
Green, EK
Greenwood, TA
Grice, DE
Gross, M
Grozeva, D
Guan, WH
Gurling, H
De Haan, L
Haines, JL
Hakonarson, H
Hallmayer, J
Hamilton, SP
Hamshere, ML
Hansen, TF
Hartmann, AM
Hautzinger, M
Heath, AC
Henders, AK
Herms, S
Hickie, IB
Hipolito, M
Hoefels, S
Holmans, PA
Holsboer, F
Hoogendijk, WJ
Hottenga, JJ
Hultman, CM
Hus, V
Ingason, A
Ising, M
Jamain, S
Jones, EG
Jones, I
Jones, L
Tzeng, JY
Kahler, AK
Kahn, RS
Kandaswamy, R
Keller, MC
Kennedy, JL
Kenny, E
Kent, L
Kim, Y
Kirov, GK
Klauck, SM
Klei, L
Knowles, JA
Kohli, MA
Koller, DL
Konte, B
Korszun, A
Krabbendam, L
Krasucki, R
Kuntsi, J
Kwan, P
Landen, M
Langstrom, N
Lathrop, M
Lawrence, J
Lawson, WB
Leboyer, M
Ledbetter, DH
Lee, PH
Lencz, T
Lesch, KP
Levinson, DF
Lewis, CM
Li, J
Lichtenstein, P
Lieberman, JA
Lin, DY
Linszen, DH
Liu, CY
Lohoff, FW
Loo, SK
Lord, C
Lowe, JK
Lucae, S
MacIntyre, DJ
Madden, PAF
Maestrini, E
Magnusson, PKE
Mahon, PB
Maier, W
Malhotra, AK
Mane, SM
Martin, CL
Martin, NG
Mattheisen, M
Matthews, K
Mattingsdal, M
McCarroll, SA
McGhee, KA
McGough, JJ
McGrath, PJ
McGuffin, P
McInnis, MG
McIntosh, A
McKinney, R
McLean, AW
McMahon, FJ
McMahon, WM
McQuillin, A
Medeiros, H
Medland, SE
Meier, S
Melle, I
Meng, F
Meyer, J
Middeldorp, CM
Middleton, L
Milanova, V
Miranda, A
Monaco, AP
Montgomery, GW
Moran, JL
Moreno-De-Luca, D
Morken, G
Morris, DW
Morrow, EM
Moskvina, V
Muglia, P
Muhleisen, TW
Muir, WJ
Muller-Myhsok, B
Murtha, M
Myers, RM
Myin-Germeys, I
Neale, MC
Nelson, SF
Nievergelt, CM
Nikolov, I
Nimgaonkar, V
Nolen, WA
Nothen, MM
Nurnberger, JI
Nwulia, EA
Nyholt, DR
O'Dushlaine, C
Oades, RD
Olincy, A
Oliveira, G
Olsen, L
Ophoff, RA
Osby, U
Owen, MJ
Palotie, A
Parr, JR
Paterson, AD
Pato, CN
Pato, MT
Penninx, BW
Pergadia, ML
Pericak-Vance, MA
Pickard, BS
Pimm, J
Piven, J
Posthuma, D
Potash, JB
Poustka, F
Propping, P
Puri, V
Quested, DJ
Quinn, EM
Ramos-Quiroga, JA
Rasmussen, HB
Raychaudhuri, S
Rehnstrom, K
Reif, A
Ribases, M
Rice, JP
Rietschel, M
Roeder, K
Roeyers, H
Rossin, L
Rothenberger, A
Rouleau, G
Ruderfer, D
Rujescu, D
Sanders, AR
Sanders, SJ
Santangelo, SL
Sergeant, JA
Schachar, R
Schalling, M
Schatzberg, AF
Scheftner, WA
Schellenberg, GD
Scherer, SW
Schork, NJ
Schulze, TG
Schumacher, J
Schwarz, M
Scolnick, E
Scott, LJ
Shi, JX
Shilling, PD
Shyn, SI
Silverman, JM
Slager, SL
Smalley, SL
Smit, JH
Smith, EN
Sonuga-Barke, EJS
St Clair, D
State, M
Steffens, M
Steinhausen, HC
Strauss, JS
Strohmaier, J
Stroup, TS
Sutcliffe, JS
Szatmari, P
Szelinger, S
Thirumalai, S
Thompson, RC
Todorov, AA
Tozzi, F
Treutlein, J
Uhr, M
van den Oord, EJCG
Van Grootheest, G
Van Os, J
Vicente, AM
Vieland, VJ
Vincent, JB
Visscher, PM
Walsh, CA
Wassink, TH
Watson, SJ
Weissman, MM
Werge, T
Wienker, TF
Wijsman, EM
Willemsen, G
Williams, N
Willsey, AJ
Witt, SH
Xu, W
Young, AH
Yu, TW
Zammit, S
Zandi, PP
Zhang, P
Zitman, FG
Zollner, S
Devlin, B
Kelsoe, JR
Sklar, P
Daly, MJ
O'Donovan, MC
Craddock, N
Sullivan, PF
Smoller, JW
Kendler, KS
Wray, NR
AF Lee, S. Hong
Ripke, Stephan
Neale, Benjamin M.
Faraone, Stephen V.
Purcell, Shaun M.
Perlis, Roy H.
Mowry, Bryan J.
Thapar, Anita
Goddard, Michael E.
Witte, John S.
Absher, Devin
Agartz, Ingrid
Akil, Huda
Amin, Farooq
Andreassen, Ole A.
Anjorin, Adebayo
Anney, Richard
Anttila, Verneri
Arking, Dan E.
Asherson, Philip
Azevedo, Maria H.
Backlund, Lena
Badner, Judith A.
Bailey, Anthony J.
Banaschewski, Tobias
Barchas, Jack D.
Barnes, Michael R.
Barrett, Thomas B.
Bass, Nicholas
Battaglia, Agatino
Bauer, Michael
Bayes, Monica
Bellivier, Frank
Bergen, Sarah E.
Berrettini, Wade
Betancur, Catalina
Bettecken, Thomas
Biederman, Joseph
Binder, Elisabeth B.
Black, Donald W.
Blackwood, Douglas H. R.
Bloss, Cinnamon S.
Boehnke, Michael
Boomsma, Dorret I.
Breen, Gerome
Breuer, Rene
Bruggeman, Richard
Cormican, Paul
Buccola, Nancy G.
Buitelaar, Jan K.
Bunney, William E.
Buxbaum, Joseph D.
Byerley, William F.
Byrne, Enda M.
Caesar, Sian
Cahn, Wiepke
Cantor, Rita M.
Casas, Miguel
Chakravarti, Aravinda
Chambert, Kimberly
Choudhury, Khalid
Cichon, Sven
Cloninger, C. Robert
Collier, David A.
Cook, Edwin H.
Coon, Hilary
Cormand, Bru
Corvin, Aiden
Coryell, William H.
Craig, David W.
Craig, Ian W.
Crosbie, Jennifer
Cuccaro, Michael L.
Curtis, David
Czamara, Darina
Datta, Susmita
Dawson, Geraldine
Day, Richard
De Geus, Eco J.
Degenhardt, Franziska
Djurovic, Srdjan
Donohoe, Gary J.
Doyle, Alysa E.
Duan, Jubao
Dudbridge, Frank
Duketis, Eftichia
Ebstein, Richard P.
Edenberg, Howard J.
Elia, Josephine
Ennis, Sean
Etain, Bruno
Fanous, Ayman
Farmer, Anne E.
Ferrier, I. Nicol
Flickinger, Matthew
Fombonne, Eric
Foroud, Tatiana
Frank, Josef
Franke, Barbara
Fraser, Christine
Freedman, Robert
Freimer, Nelson B.
Freitag, Christine M.
Friedl, Marion
Frisen, Louise
Gallagher, Louise
Gejman, Pablo V.
Georgieva, Lyudmila
Gershon, Elliot S.
Geschwind, Daniel H.
Giegling, Ina
Gill, Michael
Gordon, Scott D.
Gordon-Smith, Katherine
Green, Elaine K.
Greenwood, Tiffany A.
Grice, Dorothy E.
Gross, Magdalena
Grozeva, Detelina
Guan, Weihua
Gurling, Hugh
De Haan, Lieuwe
Haines, Jonathan L.
Hakonarson, Hakon
Hallmayer, Joachim
Hamilton, Steven P.
Hamshere, Marian L.
Hansen, Thomas F.
Hartmann, Annette M.
Hautzinger, Martin
Heath, Andrew C.
Henders, Anjali K.
Herms, Stefan
Hickie, Ian B.
Hipolito, Maria
Hoefels, Susanne
Holmans, Peter A.
Holsboer, Florian
Hoogendijk, Witte J.
Hottenga, Jouke-Jan
Hultman, Christina M.
Hus, Vanessa
Ingason, Andres
Ising, Marcus
Jamain, Stephane
Jones, Edward G.
Jones, Ian
Jones, Lisa
Tzeng, Jung-Ying
Kaehler, Anna K.
Kahn, Rene S.
Kandaswamy, Radhika
Keller, Matthew C.
Kennedy, James L.
Kenny, Elaine
Kent, Lindsey
Kim, Yunjung
Kirov, George K.
Klauck, Sabine M.
Klei, Lambertus
Knowles, James A.
Kohli, Martin A.
Koller, Daniel L.
Konte, Bettina
Korszun, Ania
Krabbendam, Lydia
Krasucki, Robert
Kuntsi, Jonna
Kwan, Phoenix
Landen, Mikael
Langstrom, Niklas
Lathrop, Mark
Lawrence, Jacob
Lawson, William B.
Leboyer, Marion
Ledbetter, David H.
Lee, Phil H.
Lencz, Todd
Lesch, Klaus-Peter
Levinson, Douglas F.
Lewis, Cathryn M.
Li, Jun
Lichtenstein, Paul
Lieberman, Jeffrey A.
Lin, Dan-Yu
Linszen, Don H.
Liu, Chunyu
Lohoff, Falk W.
Loo, Sandra K.
Lord, Catherine
Lowe, Jennifer K.
Lucae, Susanne
MacIntyre, Donald J.
Madden, Pamela A. F.
Maestrini, Elena
Magnusson, Patrik K. E.
Mahon, Pamela B.
Maier, Wolfgang
Malhotra, Anil K.
Mane, Shrikant M.
Martin, Christa L.
Martin, Nicholas G.
Mattheisen, Manuel
Matthews, Keith
Mattingsdal, Morten
McCarroll, Steven A.
McGhee, Kevin A.
McGough, James J.
McGrath, Patrick J.
McGuffin, Peter
McInnis, Melvin G.
McIntosh, Andrew
McKinney, Rebecca
McLean, Alan W.
McMahon, Francis J.
McMahon, William M.
McQuillin, Andrew
Medeiros, Helena
Medland, Sarah E.
Meier, Sandra
Melle, Ingrid
Meng, Fan
Meyer, Jobst
Middeldorp, Christel M.
Middleton, Lefkos
Milanova, Vihra
Miranda, Ana
Monaco, Anthony P.
Montgomery, Grant W.
Moran, Jennifer L.
Moreno-De-Luca, Daniel
Morken, Gunnar
Morris, Derek W.
Morrow, Eric M.
Moskvina, Valentina
Muglia, Pierandrea
Muehleisen, Thomas W.
Muir, Walter J.
Mueller-Myhsok, Bertram
Murtha, Michael
Myers, Richard M.
Myin-Germeys, Inez
Neale, Michael C.
Nelson, Stan F.
Nievergelt, Caroline M.
Nikolov, Ivan
Nimgaonkar, Vishwajit
Nolen, Willem A.
Noethen, Markus M.
Nurnberger, John I.
Nwulia, Evaristus A.
Nyholt, Dale R.
O'Dushlaine, Colm
Oades, Robert D.
Olincy, Ann
Oliveira, Guiomar
Olsen, Line
Ophoff, Roel A.
Osby, Urban
Owen, Michael J.
Palotie, Aarno
Parr, Jeremy R.
Paterson, Andrew D.
Pato, Carlos N.
Pato, Michele T.
Penninx, Brenda W.
Pergadia, Michele L.
Pericak-Vance, Margaret A.
Pickard, Benjamin S.
Pimm, Jonathan
Piven, Joseph
Posthuma, Danielle
Potash, James B.
Poustka, Fritz
Propping, Peter
Puri, Vinay
Quested, Digby J.
Quinn, Emma M.
Antoni Ramos-Quiroga, Josep
Rasmussen, Henrik B.
Raychaudhuri, Soumya
Rehnstroem, Karola
Reif, Andreas
Ribases, Marta
Rice, John P.
Rietschel, Marcella
Roeder, Kathryn
Roeyers, Herbert
Rossin, Lizzy
Rothenberger, Aribert
Rouleau, Guy
Ruderfer, Douglas
Rujescu, Dan
Sanders, Alan R.
Sanders, Stephan J.
Santangelo, Susan L.
Sergeant, Joseph A.
Schachar, Russell
Schalling, Martin
Schatzberg, Alan F.
Scheftner, William A.
Schellenberg, Gerard D.
Scherer, Stephen W.
Schork, Nicholas J.
Schulze, Thomas G.
Schumacher, Johannes
Schwarz, Markus
Scolnick, Edward
Scott, Laura J.
Shi, Jianxin
Shilling, Paul D.
Shyn, Stanley I.
Silverman, Jeremy M.
Slager, Susan L.
Smalley, Susan L.
Smit, Johannes H.
Smith, Erin N.
Sonuga-Barke, Edmund J. S.
St Clair, David
State, Matthew
Steffens, Michael
Steinhausen, Hans-Christoph
Strauss, John S.
Strohmaier, Jana
Stroup, T. Scott
Sutcliffe, James S.
Szatmari, Peter
Szelinger, Szabocls
Thirumalai, Srinivasa
Thompson, Robert C.
Todorov, Alexandre A.
Tozzi, Federica
Treutlein, Jens
Uhr, Manfred
van den Oord, Edwin J. C. G.
Van Grootheest, Gerard
Van Os, Jim
Vicente, Astrid M.
Vieland, Veronica J.
Vincent, John B.
Visscher, Peter M.
Walsh, Christopher A.
Wassink, Thomas H.
Watson, Stanley J.
Weissman, Myrna M.
Werge, Thomas
Wienker, Thomas F.
Wijsman, Ellen M.
Willemsen, Gonneke
Williams, Nigel
Willsey, A. Jeremy
Witt, Stephanie H.
Xu, Wei
Young, Allan H.
Yu, Timothy W.
Zammit, Stanley
Zandi, Peter P.
Zhang, Peng
Zitman, Frans G.
Zoellner, Sebastian
Devlin, Bernie
Kelsoe, John R.
Sklar, Pamela
Daly, Mark J.
O'Donovan, Michael C.
Craddock, Nicholas
Sullivan, Patrick F.
Smoller, Jordan W.
Kendler, Kenneth S.
Wray, Naomi R.
CA Cross-Disorder Grp Psychiat Genomi
Int Inflammatory Bowel Dis Genetic
TI Genetic relationship between five psychiatric disorders estimated from
genome-wide SNPs
SO NATURE GENETICS
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; AUTISM SPECTRUM DISORDERS; MAJOR DEPRESSIVE DISORDER; BIPOLAR
DISORDER; COMMON SNPS; CROHNS-DISEASE; SCHIZOPHRENIA; RISK; ASSOCIATION
AB Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 +/- 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 +/- 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 +/- 0.06 s.e.), and ADHD and major depressive disorder (0.32 +/- 0.07 s.e.), low between schizophrenia and ASD (0.16 +/- 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
C1 [Lee, S. Hong; Mowry, Bryan J.; Byrne, Enda M.; Visscher, Peter M.; Wray, Naomi R.] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
[Ripke, Stephan; Neale, Benjamin M.; Purcell, Shaun M.; Anttila, Verneri; Raychaudhuri, Soumya; Daly, Mark J.] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA.
[Ripke, Stephan; Neale, Benjamin M.; Purcell, Shaun M.; Anttila, Verneri; Raychaudhuri, Soumya; Daly, Mark J.] Harvard Univ, Sch Med, Boston, MA USA.
[Ripke, Stephan; Neale, Benjamin M.; Purcell, Shaun M.; Perlis, Roy H.; Bergen, Sarah E.; Chambert, Kimberly; McCarroll, Steven A.; Moran, Jennifer L.; O'Dushlaine, Colm; Raychaudhuri, Soumya; Rossin, Lizzy; Scolnick, Edward; Daly, Mark J.; Smoller, Jordan W.] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA USA.
[Faraone, Stephen V.] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA.
[Faraone, Stephen V.] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA.
[Purcell, Shaun M.; Ruderfer, Douglas; Sklar, Pamela] Icahn Sch Med Mt Sinai, Dept Psychiat, Div Psychiat Genom, New York, NY USA.
[Perlis, Roy H.; Bergen, Sarah E.; Lee, Phil H.; Smoller, Jordan W.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
[Mowry, Bryan J.] Queensland Ctr Mental Hlth Res, Wacol, Qld, Australia.
[Thapar, Anita; Fraser, Christine; Georgieva, Lyudmila; Gordon-Smith, Katherine; Grozeva, Detelina; Hamshere, Marian L.; Holmans, Peter A.; Jones, Ian; Kirov, George K.; Moskvina, Valentina; Nikolov, Ivan; Owen, Michael J.; Williams, Nigel; Zammit, Stanley; O'Donovan, Michael C.; Craddock, Nicholas] Cardiff Univ, Sch Med, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales.
[Thapar, Anita; Fraser, Christine; Georgieva, Lyudmila; Jones, Ian; Kirov, George K.; Nikolov, Ivan; Owen, Michael J.; Williams, Nigel; Zammit, Stanley; O'Donovan, Michael C.; Craddock, Nicholas] Cardiff Univ, Sch Med, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales.
[Goddard, Michael E.] Dept Environm & Primary Ind Victoria, Biosci Res Div, Melbourne, Vic, Australia.
[Goddard, Michael E.] Univ Melbourne, Fac Land & Environm, Melbourne, Vic, Australia.
[Witte, John S.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
[Absher, Devin; Myers, Richard M.] HudsonAlpha Inst Biotechnol, Huntsville, AL USA.
[Agartz, Ingrid; Andreassen, Ole A.; Djurovic, Srdjan; Mattingsdal, Morten; Melle, Ingrid] Univ Oslo, Inst Clin Med, KG Jebsen Ctr Psychosis Res, Oslo, Norway.
[Agartz, Ingrid] Diakonhjemmet Hosp, Dept Res, Oslo, Norway.
[Akil, Huda; Meng, Fan; Thompson, Robert C.; Watson, Stanley J.] Univ Michigan, Mol & Behav Neurosci Inst, Mol Psychiat Lab, Ann Arbor, MI 48109 USA.
[Amin, Farooq] Emory Univ, Atlanta Vet Affairs Med Ctr, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA.
[Andreassen, Ole A.; Melle, Ingrid] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.
[Anjorin, Adebayo; Bass, Nicholas; Choudhury, Khalid; Gurling, Hugh; Kandaswamy, Radhika; Krasucki, Robert; Lawrence, Jacob; McQuillin, Andrew; Pimm, Jonathan; Puri, Vinay] UCL, Mental Hlth Sci Unit, London, England.
[Anney, Richard; Cormican, Paul; Corvin, Aiden; Donohoe, Gary J.; Gallagher, Louise; Gill, Michael; Kenny, Elaine; Morris, Derek W.; Quinn, Emma M.] Univ Dublin Trinity Coll, Dept Psychiat, Dublin 2, Ireland.
[Arking, Dan E.; Chakravarti, Aravinda] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA.
[Asherson, Philip; Breen, Gerome; Collier, David A.; Craig, Ian W.; Farmer, Anne E.; Kuntsi, Jonna; Lewis, Cathryn M.; McGuffin, Peter] Kings Coll London, Inst Psychiat, MRC, Social Genet & Dev Psychiat SGDP Ctr, London, England.
[Azevedo, Maria H.; Oliveira, Guiomar] Univ Coimbra, Fac Med, Coimbra, Portugal.
[Backlund, Lena; Frisen, Louise; Osby, Urban; Schalling, Martin] Karolinska Inst, Ctr Mol Med, Dept Mol Med & Surg, Stockholm, Sweden.
[Badner, Judith A.; Gershon, Elliot S.] Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA.
[Bailey, Anthony J.] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
[Banaschewski, Tobias] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Mannheim, Germany.
[Barchas, Jack D.] Cornell Univ, Weill Med Coll, Dept Psychiat, New York, NY 10021 USA.
[Barnes, Michael R.] GlaxoSmithKline, London, England.
[Barrett, Thomas B.] Portland VA Med Ctr, Portland, OR USA.
[Battaglia, Agatino] Stella Maris Inst Child & Adolescent Neuropsychia, Pisa, Italy.
[Bauer, Michael] Carl Gustav Carus Univ Hosp, Dept Psychiat & Psychotherapy, Dresden, Germany.
[Bayes, Monica] Parc Cient Barcelona, Ctr Nacl Anal Genom, Barcelona, Spain.
[Bellivier, Frank; Etain, Bruno; Jamain, Stephane; Leboyer, Marion] Hop Henri Mondor, INSERM, U955, F-94010 Creteil, France.
[Bellivier, Frank] Univ Paris 07, Paris, France.
[Bellivier, Frank] Grp Hosp St Louis, AP HP, Dept Psychiat, Paris, France.
[Bellivier, Frank; Etain, Bruno; Jamain, Stephane; Leboyer, Marion] Fdn FondaMental, ENBREC European Network Bipolar Res Expert Ctr Gr, Creteil, France.
[Bergen, Sarah E.; Hultman, Christina M.; Kaehler, Anna K.; Landen, Mikael; Langstrom, Niklas; Lichtenstein, Paul; Magnusson, Patrik K. E.] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
[Berrettini, Wade; Elia, Josephine; Lohoff, Falk W.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
[Betancur, Catalina] INSERM, U952, Paris, France.
[Betancur, Catalina] CNRS, Unite Mixte Rech UMR 7224, Paris, France.
[Betancur, Catalina] Univ Paris 06, Paris, France.
[Bettecken, Thomas; Binder, Elisabeth B.; Czamara, Darina; Holsboer, Florian; Ising, Marcus; Kohli, Martin A.; Lucae, Susanne; Mueller-Myhsok, Bertram; Uhr, Manfred] Max Planck Inst Psychiat, D-80804 Munich, Germany.
[Biederman, Joseph] Massachusetts Gen Hosp, Clin & Res Programs Pediat Psychopharmacol & Adul, Boston, MA 02114 USA.
[Black, Donald W.; Coryell, William H.; Potash, James B.; Wassink, Thomas H.] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA.
[Blackwood, Douglas H. R.; MacIntyre, Donald J.; McGhee, Kevin A.; McIntosh, Andrew; McLean, Alan W.; Muir, Walter J.; Pickard, Benjamin S.] Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland.
[Bloss, Cinnamon S.; Schork, Nicholas J.; Smith, Erin N.] Scripps Translat Sci Inst, La Jolla, CA USA.
[Bloss, Cinnamon S.] Scripps Hlth, La Jolla, CA USA.
[Boehnke, Michael; Flickinger, Matthew; Guan, Weihua; Kwan, Phoenix; Scott, Laura J.; Zhang, Peng; Zoellner, Sebastian] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA.
[Boehnke, Michael; Flickinger, Matthew; Guan, Weihua; Kwan, Phoenix; Scott, Laura J.; Zhang, Peng; Zoellner, Sebastian] Univ Michigan, Sch Publ Hlth, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
[Boomsma, Dorret I.; De Geus, Eco J.; Hottenga, Jouke-Jan; Middeldorp, Christel M.; Willemsen, Gonneke] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
[Boomsma, Dorret I.; De Geus, Eco J.; Penninx, Brenda W.; Smit, Johannes H.; Van Grootheest, Gerard; Willemsen, Gonneke] EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
[Boomsma, Dorret I.; De Geus, Eco J.; Hottenga, Jouke-Jan; Middeldorp, Christel M.; Penninx, Brenda W.] Neurosci Campus Amsterdam, Amsterdam, Netherlands.
[Breen, Gerome] Natl Inst Heath Res, Biomed Res Ctr Mental Hlth, London, England.
[Breen, Gerome] Maudsley Natl Hlth Serv NHS Trust, London, England.
[Breen, Gerome] Inst Psychiat, London, England.
[Breuer, Rene; Frank, Josef; Meier, Sandra; Rietschel, Marcella; Strohmaier, Jana; Treutlein, Jens; Witt, Stephanie H.] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany.
[Bruggeman, Richard] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
[Buccola, Nancy G.] Louisiana State Univ, Sch Nursing, Hlth Sci Ctr, New Orleans, LA USA.
[Buitelaar, Jan K.; Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands.
[Bunney, William E.] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Psychiat, Seaver Autism Ctr Res & Treatment, New York, NY USA.
[Byerley, William F.; Hamilton, Steven P.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
[Byerley, William F.] NCIRE Northern Calif Inst Q Res & Educ, San Francisco, CA USA.
[Caesar, Sian; Gordon-Smith, Katherine; Jones, Lisa] Univ Birmingham, Dept Psychiat, Birmingham, W Midlands, England.
[Cahn, Wiepke; Kahn, Rene S.] Univ Med Ctr, Rudolf Magnus Inst Neurosci, Dept Psychiat, Utrecht, Netherlands.
[Cantor, Rita M.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
[Casas, Miguel; Antoni Ramos-Quiroga, Josep; Ribases, Marta] Hosp Univ Vall Hebron, CIBERSAM Ctr Invest Biomed Area Salud Mental, Dept Psychiat, Barcelona, Spain.
[Casas, Miguel; Antoni Ramos-Quiroga, Josep] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, E-08193 Barcelona, Spain.
[Cichon, Sven; Degenhardt, Franziska; Herms, Stefan; Muehleisen, Thomas W.; Noethen, Markus M.] Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.
[Cichon, Sven] Res Ctr Julich, Inst Neurosci & Med INM 1, Julich, Germany.
[Cichon, Sven; Degenhardt, Franziska; Mattheisen, Manuel; Muehleisen, Thomas W.; Noethen, Markus M.; Propping, Peter; Schumacher, Johannes] Univ Bonn, Inst Human Genet, Bonn, Germany.
[Cichon, Sven; Herms, Stefan] Univ Basel, Div Med Genet, Dept Biomed, Basel, Switzerland.
[Cloninger, C. Robert; Heath, Andrew C.; Madden, Pamela A. F.; Pergadia, Michele L.; Todorov, Alexandre A.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
[Cook, Edwin H.] Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60612 USA.
[Coon, Hilary; McMahon, William M.] Univ Utah, Dept Psychiat, Salt Lake City, UT USA.
[Cormand, Bru] Univ Barcelona, Fac Biol, Dept Genet, Barcelona, Spain.
[Cormand, Bru] Biomed Network Res Ctr Rare Dis CIBERER, Barcelona, Spain.
[Cormand, Bru] Univ Barcelona IBUB, Inst Biomed, Barcelona, Spain.
[Craig, David W.; Szelinger, Szabocls] Translat Genom Res Inst, Phoenix, AZ USA.
[Crosbie, Jennifer; Schachar, Russell] Univ Toronto, Hosp Sick Children, Neurosci & Mental Hlth Program, Toronto, ON M5G 1X8, Canada.
[Cuccaro, Michael L.; Pericak-Vance, Margaret A.] Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA.
[Curtis, David] Univ London, East London NHS Fdn Trust, London, England.
[Czamara, Darina; Mueller-Myhsok, Bertram] Munich Cluster Syst Neurol SyNergy, Munich, Germany.
[Datta, Susmita] UCL, Genet Inst, London, England.
[Dawson, Geraldine] Autism Speaks, New York, NY USA.
[Dawson, Geraldine] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
[Dawson, Geraldine; Piven, Joseph] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC USA.
[Day, Richard; Matthews, Keith] Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Div Neurosci, Dundee DD1 9SY, Scotland.
[Djurovic, Srdjan] Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.
[Doyle, Alysa E.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
[Duan, Jubao; Gejman, Pablo V.; Sanders, Alan R.] NorthShore Univ Hlth Syst, Dept Psychiat & Behav Sci, Evanston, IL USA.
[Duan, Jubao; Gejman, Pablo V.; Sanders, Alan R.] Univ Chicago, Evanston, IL USA.
[Dudbridge, Frank] London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1, England.
[Duketis, Eftichia; Freitag, Christine M.; Poustka, Fritz] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60054 Frankfurt, Germany.
[Ebstein, Richard P.] Natl Univ Singapore, Dept Psychol, Singapore 117548, Singapore.
[Edenberg, Howard J.] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA.
[Edenberg, Howard J.; Foroud, Tatiana; Koller, Daniel L.; Nurnberger, John I.] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.
[Elia, Josephine] Univ Penn, AI Dupont Hosp Children, Philadelphia, PA 19104 USA.
[Ennis, Sean] Univ Coll Med Sci, Sch Med, Dublin, Ireland.
[Etain, Bruno; Jamain, Stephane; Leboyer, Marion] Univ Paris Est, Fac Med, Creteil, France.
[Etain, Bruno; Jamain, Stephane; Leboyer, Marion] Hop H Mondor A Chenevier, AP HP, Dept Psychiat, Creteil, France.
[Fanous, Ayman] Georgetown Univ, Sch Med, Dept Psychiat, Washington, DC USA.
[Fanous, Ayman; Neale, Michael C.; Kendler, Kenneth S.] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA.
[Ferrier, I. Nicol; Parr, Jeremy R.; Young, Allan H.] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Fombonne, Eric] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97201 USA.
[Fombonne, Eric] Oregon Hlth & Sci Univ, Inst Dev & Disabil, Portland, OR 97201 USA.
[Freedman, Robert; Olincy, Ann] Univ Colorado Denver, Dept Psychiat, Aurora, CO USA.
[Freimer, Nelson B.; Loo, Sandra K.; Nelson, Stan F.; Ophoff, Roel A.; Smalley, Susan L.] Univ Calif Los Angeles, Dept Neurobehav Genet, Los Angeles, CA USA.
[Friedl, Marion; Giegling, Ina; Hartmann, Annette M.; Konte, Bettina; Rujescu, Dan] Univ Halle, Dept Psychiat, Halle, Germany.
[Geschwind, Daniel H.; Lowe, Jennifer K.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA.
[Geschwind, Daniel H.; Lowe, Jennifer K.] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst, Ctr Autism Res & Treatment, Los Angeles, CA 90095 USA.
[Gordon, Scott D.; Henders, Anjali K.; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Nyholt, Dale R.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia.
[Green, Elaine K.] Univ Plymouth, Dept Biomed & Biol Sci, Plymouth PL4 8AA, Devon, England.
[Greenwood, Tiffany A.; McKinney, Rebecca; Nievergelt, Caroline M.; Shilling, Paul D.; Kelsoe, John R.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
[Grice, Dorothy E.] Icahn Sch Med Mt Sinai, Div Tics OCD & Related Disorders, New York, NY USA.
[Grice, Dorothy E.; Silverman, Jeremy M.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY USA.
[Gross, Magdalena; Hoefels, Susanne; Maier, Wolfgang] Univ Bonn, Dept Psychiat, Bonn, Germany.
[Guan, Weihua] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
[De Haan, Lieuwe] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1012 WX Amsterdam, Netherlands.
[Haines, Jonathan L.] Vanderbilt Univ, Med Ctr, Ctr Human Genet Res, Nashville, TN USA.
[Hakonarson, Hakon] Childrens Hosp Philadelphia, Ctr Appl Genom, Div Human Genet, Philadelphia, PA 19104 USA.
[Hakonarson, Hakon] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
[Hallmayer, Joachim] Stanford Univ, Sch Med, Dept Psychiat, Stanford, CA 94305 USA.
[Hamshere, Marian L.; Holmans, Peter A.; Moskvina, Valentina] Cardiff Univ, Biostat & Bioinformat Unit, Cardiff, S Glam, Wales.
[Hansen, Thomas F.; Ingason, Andres; Olsen, Line; Rasmussen, Henrik B.; Werge, Thomas] Copenhagen Univ Hosp, Inst Biol Psychiat, Roskilde, Denmark.
[Hansen, Thomas F.; Ingason, Andres; Mattheisen, Manuel; Olsen, Line; Rasmussen, Henrik B.; Werge, Thomas] iPSYCH, Lundbeck Initiat Integrat Psychiat Res, Roskilde, Denmark.
[Hautzinger, Martin] Univ Tubingen, Dept Clin & Dev Psychol, Tubingen, Germany.
[Hickie, Ian B.] Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
[Hipolito, Maria; Lawson, William B.; Nwulia, Evaristus A.] Howard Univ, Coll Med, Dept Psychiat & Behav Sci, Washington, DC USA.
[Hoogendijk, Witte J.] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands.
[Hus, Vanessa] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
[Jones, Edward G.] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA.
[Tzeng, Jung-Ying] N Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA.
[Keller, Matthew C.] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA.
[Kennedy, James L.] Ctr Addict & Mental Hlth, Psychiat Neurogenet Sect, Toronto, ON, Canada.
[Kent, Lindsey] Univ St Andrews, Sch Med, St Andrews, Fife, Scotland.
[Kim, Yunjung; Sullivan, Patrick F.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
[Klauck, Sabine M.] German Canc Res Ctr, Div Mol Genome Anal, Heidelberg, Germany.
[Klei, Lambertus; Devlin, Bernie] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
[Knowles, James A.; Medeiros, Helena; Pato, Carlos N.; Pato, Michele T.] Univ So Calif, Keck Sch Med, Dept Psychiat, Zilkha Neurogenet Inst, Los Angeles, CA 90033 USA.
[Korszun, Ania] Queen Mary Univ London, Wolfson Inst Preventit Med, London, England.
[Krabbendam, Lydia; Myin-Germeys, Inez; Van Os, Jim] Maastricht Univ, Med Ctr, South Limburg Mental Hlth Res & Teaching Network, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
[Landen, Mikael] Univ Gothenburg, Inst Neurosci & Physiol, Gothenburg, Sweden.
[Lathrop, Mark] Ctr Natl Genotypage, Evry, France.
[Ledbetter, David H.; Martin, Christa L.] Geisinger Hlth Syst, Autism & Dev Med Inst, Danville, PA USA.
[Lencz, Todd; Malhotra, Anil K.] Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div North Shore, Dept Psychiat,Div Res, Glen Oaks, NY USA.
[Lencz, Todd; Malhotra, Anil K.] Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA.
[Lencz, Todd; Malhotra, Anil K.] Yeshiva Univ, Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY USA.
[Lesch, Klaus-Peter] Univ Wurzburg, ADHD Clin Res Unit, Dept Psychiat Psychosomat & Psychotherapy, Div Mol Psychiat, D-97070 Wurzburg, Germany.
[Lesch, Klaus-Peter] Maastricht Univ, Sch Mental Hlth & Neurosci MHENS, Dept Psychiat & Psychol, Maastricht, Netherlands.
[Levinson, Douglas F.] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
[Li, Jun] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
[Lieberman, Jeffrey A.; McGrath, Patrick J.] Columbia Univ, New York State Psychiat Inst, New York, NY USA.
[Lin, Dan-Yu] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA.
[Linszen, Don H.] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands.
[Liu, Chunyu] Univ Illinois, Dept Psychiat, Inst Human Genet, Chicago, IL 60612 USA.
[Loo, Sandra K.; Smalley, Susan L.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
[Lord, Catherine] Weill Cornell Med Coll, Ctr Autism & Developing Brain, White Plains, NY USA.
[Maestrini, Elena] Univ Bologna, Dept Pharm & Biotechnol, Bologna, Italy.
[Mahon, Pamela B.; Schulze, Thomas G.] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD USA.
[Mane, Shrikant M.] Yale Ctr Genome Anal, Orange, CT USA.
[Mattheisen, Manuel] Aarhus Univ, Dept Biomed, Aarhus, Denmark.
[Mattheisen, Manuel] Univ Bonn, Dept Genom Math, Bonn, Germany.
[Mattingsdal, Morten] Sorlandet Hosp, Kristiansand, Norway.
[McGough, James J.] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst, Los Angeles, CA 90095 USA.
[McInnis, Melvin G.; Zhang, Peng; Zoellner, Sebastian] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
[McIntosh, Andrew; McLean, Alan W.; Muir, Walter J.; Pickard, Benjamin S.] Univ Edinburgh, Mol Med Ctr, Edinburgh, Midlothian, Scotland.
[McMahon, Francis J.] NIMH, US Natl Inst Hlth, Bethesda, MD 20892 USA.
[Meyer, Jobst] Univ Trier, Dept Neurobehav Genet, Trier, Germany.
[Middleton, Lefkos] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England.
[Milanova, Vihra] Alexander Univ Hosp, Psychiat Clin 1, Dept Psychiat, Sofia, Bulgaria.
[Miranda, Ana] Univ Valencia, Dept Dev & Educ Psychol, Valencia, Spain.
[Monaco, Anthony P.] Univ Oxford, Ctr Human Genet, Wellcome Trust, Oxford, England.
[Monaco, Anthony P.] Tufts Univ, Off President, Medford, MA 02155 USA.
[Moreno-De-Luca, Daniel; Sanders, Stephan J.; State, Matthew] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA.
[Morken, Gunnar] St Olavs Hosp, Dept Psychiat, Trondheim, Norway.
[Morken, Gunnar] Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway.
[Morrow, Eric M.] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA.
[Morrow, Eric M.] Brown Univ, Dept Psychiat & Human Behav, Providence, RI 02912 USA.
[Muglia, Pierandrea; Tozzi, Federica] GlaxoSmithKline Res & Dev Ltd, Neurosci Ctr Excellence Drug Discovery, Verona, Italy.
[Muehleisen, Thomas W.] Univ Bonn, Life & Brain Ctr, Bonn, Germany.
[Murtha, Michael; Sanders, Stephan J.; State, Matthew; Willsey, A. Jeremy] Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
[Nimgaonkar, Vishwajit] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
[Nimgaonkar, Vishwajit] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA.
[Nolen, Willem A.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
[Nurnberger, John I.] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
[Oades, Robert D.] Univ Duisburg Essen, Clin Child & Adolescent Psychiat & Psychotherapy, Essen, Germany.
[Oliveira, Guiomar] Ctr Hosp Coimbra, Pediat Hosp, Res & Clin Training Dept, Coimbra, Portugal.
[Oliveira, Guiomar] Univ Coimbra, Coimbra, Portugal.
[Ophoff, Roel A.] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA.
[Ophoff, Roel A.] Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.
[Palotie, Aarno; Rehnstroem, Karola] Sanger Inst, Cambridge, England.
[Paterson, Andrew D.] Hosp Sick Children, Program Genet & Genom Biol, Toronto, ON M5G 1X8, Canada.
[Paterson, Andrew D.; Xu, Wei] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
[Penninx, Brenda W.; Smit, Johannes H.; Van Grootheest, Gerard] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
[Posthuma, Danielle] Vrije Univ Amsterdam Med Ctr, Dept Funct Genom, Amsterdam, Netherlands.
[Posthuma, Danielle] Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands.
[Posthuma, Danielle] Erasmus Univ, Med Ctr, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands.
[Quested, Digby J.] Univ Oxford, Acad Dept Psychiat, Oxford, England.
[Reif, Andreas] Univ Wurzburg, Dept Psychiat, Wurzburg, Germany.
[Ribases, Marta] Vall dHebron Res Inst, Psychiat Genet Unit, Barcelona, Spain.
[Rice, John P.] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA.
[Roeder, Kathryn] Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA.
[Roeyers, Herbert; Sonuga-Barke, Edmund J. S.] Univ Ghent, Dept Expt Clin & Hlth Psychol, B-9000 Ghent, Belgium.
[Rothenberger, Aribert] Univ Med Gottingen, Gottingen, Germany.
[Rouleau, Guy] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada.
[Sanders, Stephan J.; State, Matthew; Willsey, A. Jeremy] Yale Univ, Dept Genet, New Haven, CT USA.
[Sanders, Stephan J.] Yale Univ, Program Neurogenet, New Haven, CT USA.
[Santangelo, Susan L.] Maine Med Ctr, Dept Psychiat, Portland, ME 04102 USA.
[Santangelo, Susan L.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
[Sergeant, Joseph A.] Vrije Univ Amsterdam, Dept Clin Neuropsychol, Amsterdam, Netherlands.
[Schatzberg, Alan F.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA.
[Scheftner, William A.] Rush Univ, Med Ctr, Rush Ambulatory Behav Hlth, Chicago, IL 60612 USA.
[Schellenberg, Gerard D.] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA.
[Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1X8, Canada.
[Schork, Nicholas J.; Smith, Erin N.] Scripps Res Inst, La Jolla, CA 92037 USA.
[Schulze, Thomas G.] Univ Gottingen, Dept Psychiat & Psychotherapy, D-37073 Gottingen, Germany.
[Schwarz, Markus] Psychiat Ctr Nordbaden, Wiesloch, Germany.
[Shi, Jianxin] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Shyn, Stanley I.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Slager, Susan L.] Mayo Clin, Rochester, MN USA.
[Sonuga-Barke, Edmund J. S.] Univ Southampton, Dev Brain & Behav Lab, Acad Unit Psychol, Southampton, Hants, England.
[St Clair, David] Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland.
[Steffens, Michael] Fed Inst Drugs & Med Devices BfArM, Res Dept, Bonn, Germany.
[Steinhausen, Hans-Christoph] Aalborg Univ Hosp, Res Unit Child & Adolescent Psychiat, Aalborg, Denmark.
[Steinhausen, Hans-Christoph] Univ Basel, Basel, Switzerland.
[Steinhausen, Hans-Christoph] Univ Zurich, Dept Child & Adolescent Psychiat, Zurich, Switzerland.
[Strauss, John S.; Vincent, John B.] Ctr Addict & Mental Hlth, Mol Neuropsychiat & Dev Lab, Toronto, ON, Canada.
[Stroup, T. Scott] Columbia Univ, Dept Psychiat, New York, NY USA.
[Sutcliffe, James S.] Vanderbilt Univ, Vanderbilt Brain Inst, Nashville, TN 37235 USA.
[Szatmari, Peter] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
[Szatmari, Peter] Hosp Sick Children, Neurosci & Mental Hlth Program, Toronto, ON M5G 1X8, Canada.
[Szatmari, Peter] Ctr Addict & Mental Hlth, Toronto, ON, Canada.
[Thirumalai, Srinivasa] Oxford Hlth NHS Fdn Trust, Marlborough House Secure Unit, Milton Keynes, Bucks, England.
[van den Oord, Edwin J. C. G.] Virginia Commonwealth Univ, Ctr Biomarker Res & Personalized Med, Richmond, VA USA.
[Vicente, Astrid M.] Inst Nacl Saude Dr Ricardo Jorge, Lisbon, Portugal.
[Vicente, Astrid M.] BioFIG Ctr Biodivers Funct & Integrat Genom, Lisbon, Portugal.
[Vicente, Astrid M.] Inst Gulbenkian Ciencias, Lisbon, Portugal.
[Vieland, Veronica J.] Nationwide Childrens Hosp, Battelle Ctr Math Med, Columbus, OH USA.
[Visscher, Peter M.] Univ Queensland, Diamantina Inst, Brisbane, Qld, Australia.
[Walsh, Christopher A.] Childrens Hosp, Howard Hughes Med Inst, Boston, MA 02115 USA.
[Walsh, Christopher A.] Childrens Hosp, Div Genet, Boston, MA 02115 USA.
[Walsh, Christopher A.] Harvard Univ, Sch Med, Dept Neurol, Ctr Life Sci, Boston, MA 02115 USA.
[Walsh, Christopher A.] Harvard Univ, Sch Med, Dept Pediat, Ctr Life Sci, Boston, MA 02115 USA.
[Weissman, Myrna M.] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA.
[Werge, Thomas] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
[Wienker, Thomas F.] Univ Bonn, Inst Med Biometry, Bonn, Germany.
[Wijsman, Ellen M.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
[Wijsman, Ellen M.] Univ Washington, Dept Med, Seattle, WA USA.
[Young, Allan H.] Kings Coll London, Inst Psychiat, Ctr Affect Disorders, London, England.
[Yu, Timothy W.] Harvard Univ, Childrens Hosp Boston, Sch Med, Div Genet, Boston, MA USA.
[Zandi, Peter P.] Johns Hopkins Univ, Dept Mental Hlth, Baltimore, MD USA.
[Zitman, Frans G.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
[Kelsoe, John R.] Vet Affairs San Diego Healthcare Syst, Special Treatment & Evaluat Program, Dept Psychiat, San Diego, CA USA.
[Kendler, Kenneth S.] Virginia Commonwealth Univ, Dept Human & Mol Genet, Richmond, VA USA.
[Kendler, Kenneth S.] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA USA.
RP Wray, NR (reprint author), Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
EM naomi.wray@uq.edu.au
RI Franke, Barbara/D-4836-2009; Morrow, Eric/J-2767-2013; McGuffin,
Peter/A-1565-2012; Sonuga-Barke, Edmund/D-9137-2011; McIntosh,
Andrew/B-9379-2008; Kuntsi, Jonna/G-9750-2011; Scherer, Stephen
/B-3785-2013; Cichon, Sven/H-8803-2013; Cichon, Sven/B-9618-2014; van
Grootheest, Gerard/C-6942-2014; Kahler, Anna/J-2874-2012; McQuillin,
Andrew/C-1623-2008; Nolen, Willem/E-9006-2014; Nyholt, Dale/C-8384-2013;
Monaco, Anthony/A-4495-2010; Bailey, Anthony/J-2860-2014; Liu,
Chang/B-7249-2009; Thompson, Richard/J-8879-2014; Binder,
Elisabeth/K-8905-2014; Myin-Germeys, Inez /L-5106-2014; Zhang,
Peng/N-2920-2014; Lee, Sang Hong/A-2569-2011; Breen, Gerome/A-5540-2010;
Hansen, Thomas/O-5965-2014; Lesch, Klaus-Peter/J-4906-2013; Wray,
Naomi/C-8639-2015; Mowry, Bryan /G-5046-2010; Holmans,
Peter/F-4518-2015; Sutcliffe, James/C-1348-2012
OI Franke, Barbara/0000-0003-4375-6572; McGuffin,
Peter/0000-0002-9888-2907; McIntosh, Andrew/0000-0002-0198-4588;
Scherer, Stephen /0000-0002-8326-1999; Cichon, Sven/0000-0002-9475-086X;
Cichon, Sven/0000-0002-9475-086X; van Grootheest,
Gerard/0000-0003-4350-6661; McQuillin, Andrew/0000-0003-1567-2240;
Monaco, Anthony/0000-0001-7480-3197; Bailey,
Anthony/0000-0003-4257-972X; Zhang, Peng/0000-0003-1182-1392; Lee, Sang
Hong/0000-0001-9701-2718; Breen, Gerome/0000-0003-2053-1792; Hansen,
Thomas/0000-0001-6703-7762; Lesch, Klaus-Peter/0000-0001-8348-153X;
Wray, Naomi/0000-0001-7421-3357; Holmans, Peter/0000-0003-0870-9412;
Sutcliffe, James/0000-0001-5200-6007
FU Australian Research Council [FT0991360, DE130100614]; Australian
National Health and Medical Research Council [613608, 1011506, 1047956];
National Institute of Mental Health (NIMH) [U01 MH085520]; Netherlands
Scientific Organization (NOW) [480-05-003]; Dutch Brain Foundation; VU
University
FX This research was directly supported by the Australian Research Council
(FT0991360 and DE130100614) and the Australian National Health and
Medical Research Council (613608, 1011506 and 1047956). The PGC
Cross-Disorder Group is supported by National Institute of Mental Health
(NIMH) grant U01 MH085520. Statistical analyses were carried out on the
Genetic Cluster Computer (see URLs), which is financially supported by
the Netherlands Scientific Organization (NOW; 480-05-003; principal
investigator D.P.) along with a supplement from the Dutch Brain
Foundation and VU University. Numerous (> 100) grants from government
agencies along with substantial private and foundation support worldwide
enabled the collection of phenotype and genotype data, without which
this research would not be possible; grant numbers are listed in primary
PGC publications or in the Supplementary Note.
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NR 64
TC 147
Z9 148
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
J9 NAT GENET
JI Nature Genet.
PD SEP
PY 2013
VL 45
IS 9
BP 984
EP +
DI 10.1038/ng.2711
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA 209ID
UT WOS:000323748200007
ER
PT J
AU Buchovecky, CM
Turley, SD
Brown, HM
Kyle, SM
McDonald, JG
Liu, B
Pieper, AA
Huang, WH
Katz, DM
Russell, DW
Shendure, J
Justice, MJ
AF Buchovecky, Christie M.
Turley, Stephen D.
Brown, Hannah M.
Kyle, Stephanie M.
McDonald, Jeffrey G.
Liu, Benny
Pieper, Andrew A.
Huang, Wenhui
Katz, David M.
Russell, David W.
Shendure, Jay
Justice, Monica J.
TI A suppressor screen in Mecp2 mutant mice implicates cholesterol
metabolism in Rett syndrome
SO NATURE GENETICS
LA English
DT Article
ID CPG-BINDING PROTEIN-2; MOUSE MODEL; SQUALENE EPOXIDASE;
BRAIN-DEVELOPMENT; LIPID-METABOLISM; NEURONS; MUTATIONS; LANOSTEROL;
TURNOVER; REVEALS
AB Mutations in MECP2, encoding methyl CpG-binding protein 2, cause Rett syndrome, the most severe autism spectrum disorder. Re-expressing Mecp2 in symptomatic Mecp2-null mice markedly improves function and longevity, providing hope that therapeutic intervention is possible in humans. To identify pathways in disease pathology for therapeutic intervention, we carried out a dominant N-ethyl-N-nitrosourea (ENU) mutagenesis suppressor screen in Mecp2-null mice and isolated five suppressors that ameliorate the symptoms of Mecp2 loss. We show that a stop codon mutation in Sqle, encoding squalene epoxidase, a rate-limiting enzyme in cholesterol biosynthesis, underlies suppression in one line. Subsequently, we also show that lipid metabolism is perturbed in the brains and livers of Mecp2-null male mice. Consistently, statin drugs improve systemic perturbations of lipid metabolism, alleviate motor symptoms and confer increased longevity in Mecp2 mutant mice. Our genetic screen therefore points to cholesterol homeostasis as a potential target for the treatment of patients with Rett syndrome.
C1 [Buchovecky, Christie M.; Brown, Hannah M.; Kyle, Stephanie M.; Justice, Monica J.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Turley, Stephen D.; Liu, Benny] Univ Texas Dallas, SW Med Sch, Dept Internal Med, Dallas, TX 75230 USA.
[McDonald, Jeffrey G.; Russell, David W.] Univ Texas Dallas, SW Med Sch, Dept Mol Genet, Dallas, TX 75230 USA.
[Pieper, Andrew A.] Univ Texas Dallas, SW Med Sch, Dept Psychiat, Dallas, TX 75230 USA.
[Pieper, Andrew A.] Univ Texas Dallas, SW Med Sch, Dept Biochem, Dallas, TX 75230 USA.
[Huang, Wenhui; Shendure, Jay] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
[Katz, David M.] Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA.
RP Justice, MJ (reprint author), Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
EM mjustice@bcm.edu
FU RSRT; Rett Syndrome Research Foundation; International Rett Syndrome
Foundation [2608, 2583]; Autism Science Foundation [11-1015]; US
National Institutes of Health (NIH) [NIH T32 GM08307, NIH U54 GM69338,
NIH R01 HL09610, NIH R01 CA115503]; National Institute of Neurologic
Diseases and Stroke; American Recovery and Reinvestment Act; NIH Eunice
Kennedy Shriver National Institute of Child Health and Human Development
[2P30DK079638-05, 5P30HD024064-23]
FX The work was supported by grants from the RSRT, the Rett Syndrome
Research Foundation, the International Rett Syndrome Foundation (ANGEL
award 2608 to M.J.J. and ANGEL award 2583 to D.M.K.), Autism Science
Foundation predoctoral fellowship # 11-1015, US National Institutes of
Health (NIH) grants NIH T32 GM08307 to C. M. B., NIH U54 GM69338 to D.
W. R., NIH R01 HL09610 to S. D. T. and NIH R01 CA115503 to M.J.J. and
the National Institute of Neurologic Diseases and Stroke, including
funding from the American Recovery and Reinvestment Act (D.M.K.). Grants
to the BCM Diabetes and Endocrinology Research Center (2P30DK079638-05)
and the BCM Intellectual and Developmental Disabilities Research Center
(5P30HD024064-23) from the NIH Eunice Kennedy Shriver National Institute
of Child Health and Human Development also supported this work. The
content is solely the responsibility of the authors and does not
necessarily represent the official views of the Eunice Kennedy Shriver
National Institute of Child Health and Human Development or the NIH.
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NR 63
TC 17
Z9 19
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
J9 NAT GENET
JI Nature Genet.
PD SEP
PY 2013
VL 45
IS 9
BP 1013
EP +
DI 10.1038/ng.2714
PG 10
WC Genetics & Heredity
SC Genetics & Heredity
GA 209ID
UT WOS:000323748200010
PM 23892605
ER
PT J
AU Carvill, GL
Regan, BM
Yendle, SC
O'Roak, BJ
Lozovaya, N
Bruneau, N
Burnashev, N
Khan, A
Cook, J
Geraghty, E
Sadleir, LG
Turner, SJ
Tsai, MH
Webster, R
Ouvrier, R
Damiano, JA
Berkovic, SF
Shendure, J
Hildebrand, MS
Szepetowski, P
Scheffer, IE
Mefford, HC
AF Carvill, Gemma L.
Regan, Brigid M.
Yendle, Simone C.
O'Roak, Brian J.
Lozovaya, Natalia
Bruneau, Nadine
Burnashev, Nail
Khan, Adiba
Cook, Joseph
Geraghty, Eileen
Sadleir, Lynette G.
Turner, Samantha J.
Tsai, Meng-Han
Webster, Richard
Ouvrier, Robert
Damiano, John A.
Berkovic, Samuel F.
Shendure, Jay
Hildebrand, Michael S.
Szepetowski, Pierre
Scheffer, Ingrid E.
Mefford, Heather C.
TI GRIN2A mutations cause epilepsy-aphasia spectrum disorders
SO NATURE GENETICS
LA English
DT Article
ID DE-NOVO MUTATIONS; INTELLECTUAL DISABILITY; ROLANDIC EPILEPSY; ACQUIRED
APHASIA; SPEECH; AUTISM; ENCEPHALOPATHIES; CHILDHOOD; SPIKES; SLEEP
AB Epilepsy-aphasia syndromes (EAS) are a group of rare, severe epileptic encephalopathies of unknown etiology with a characteristic electroencephalogram (EEG) pattern and developmental regression particularly affecting language. Rare pathogenic deletions that include GRIN2A have been implicated in neurodevelopmental disorders. We sought to delineate the pathogenic role of GRIN2A in 519 probands with epileptic encephalopathies with diverse epilepsy syndromes. We identified four probands with GRIN2A variants that segregated with the disorder in their families. Notably, all four families presented with EAS, accounting for 9% of epilepsyaphasia cases. We did not detect pathogenic variants in GRIN2A in other epileptic encephalopathies (n = 475) nor in probands with benign childhood epilepsy with centrotemporal spikes (n = 81). We report the first monogenic cause, to our knowledge, for EAS. GRIN2A mutations are restricted to this group of cases, which has important ramifications for diagnostic testing and treatment and provides new insights into the pathogenesis of this debilitating group of conditions.
C1 [Carvill, Gemma L.; Khan, Adiba; Cook, Joseph; Geraghty, Eileen; Mefford, Heather C.] Univ Washington, Dept Pediat, Div Med Genet, Seattle, WA 98195 USA.
[Regan, Brigid M.; Yendle, Simone C.; Turner, Samantha J.; Tsai, Meng-Han; Damiano, John A.; Berkovic, Samuel F.; Hildebrand, Michael S.; Scheffer, Ingrid E.] Univ Melbourne, Dept Med, Epilepsy Res Ctr, Austin Hlth, Melbourne, Vic, Australia.
[O'Roak, Brian J.; Shendure, Jay] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
[Lozovaya, Natalia; Bruneau, Nadine; Burnashev, Nail; Szepetowski, Pierre] Mediterranean Inst Neurobiol INMED, Marseille, France.
[Lozovaya, Natalia; Bruneau, Nadine; Burnashev, Nail; Szepetowski, Pierre] INSERM, UMRS 901, F-13258 Marseille, France.
[Lozovaya, Natalia; Bruneau, Nadine; Burnashev, Nail; Szepetowski, Pierre] Aix Marseille Univ, Marseille, France.
[Lozovaya, Natalia] Paris Descartes Univ, INSERM, UMRS 663, Paris, France.
[Bruneau, Nadine; Burnashev, Nail; Szepetowski, Pierre] French EPILAND Network Epilepsy Language & Dev, Marseille, France.
[Sadleir, Lynette G.] Univ Otago, Sch Med & Hlth Sci, Dept Pediat, Wellington, New Zealand.
[Turner, Samantha J.; Scheffer, Ingrid E.] Univ Melbourne, Dept Pediat, Royal Childrens Hosp, Melbourne, Vic, Australia.
[Webster, Richard; Ouvrier, Robert] Childrens Hosp Westmead, TY Nelson Dept Neurol & Neurosurg, Sydney, NSW, Australia.
[Scheffer, Ingrid E.] Florey Inst, Melbourne, Vic, Australia.
RP Mefford, HC (reprint author), Univ Washington, Dept Pediat, Div Med Genet, Seattle, WA 98195 USA.
EM scheffer@unimelb.edu.au; hmefford@u.washington.edu
RI Scheffer, Ingrid/G-1668-2013
OI Scheffer, Ingrid/0000-0002-2311-2174
FU US National Institutes of Health (NIH; NINDS) [1R01NS069605]; Burroughs
Wellcome Fund Career Award for Medical Scientists; National Health and
Medical Research Council of Australia [628952, 1006110, 546493]; Health
Research Council of New Zealand; ANR (Agence Nationale de la Recherche);
INSERM
FX We thank the subjects and their families for participating in our
research. H. C. M. is supported by a grant from the US National
Institutes of Health (NIH; NINDS 1R01NS069605) and is a recipient of a
Burroughs Wellcome Fund Career Award for Medical Scientists. This work
was supported by the National Health and Medical Research Council of
Australia (Program Grant 628952 to S. F. B. and I. E. S., Practitioner
Fellowship 1006110 to I. E. S. and CJ Martin Fellowship (546493) to M.
S. H.) and by a Health Research Council of New Zealand project grant to
L. G. S. P. S. is supported by ANR (Agence Nationale de la Recherche)
grant EPILAND with EuroBiomed label, and P. S., N. Burnashev and N.
Bruneau are supported by INSERM.
CR Berg AT, 2010, EPILEPSIA, V51, P676, DOI 10.1111/j.1528-1167.2010.02522.x
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NR 19
TC 39
Z9 40
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
J9 NAT GENET
JI Nature Genet.
PD SEP
PY 2013
VL 45
IS 9
BP 1073
EP +
DI 10.1038/ng.2727
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA 209ID
UT WOS:000323748200019
PM 23933818
ER
PT J
AU Xu, DY
Shen, WP
Guo, R
Xue, YT
Peng, W
Sima, J
Yang, J
Sharov, A
Srikantan, S
Yang, JD
Fox, D
Qian, Y
Martindale, JL
Piao, YL
Machamer, J
Joshi, SR
Mohanty, S
Shaw, AC
Lloyd, TE
Brown, GW
Ko, MSH
Gorospe, M
Zou, SG
Wang, WD
AF Xu, Dongyi
Shen, Weiping
Guo, Rong
Xue, Yutong
Peng, Wei
Sima, Jian
Yang, Jay
Sharov, Alexei
Srikantan, Subramanya
Yang, Jiandong
Fox, David, III
Qian, Yong
Martindale, Jennifer L.
Piao, Yulan
Machamer, James
Joshi, Samit R.
Mohanty, Subhasis
Shaw, Albert C.
Lloyd, Thomas E.
Brown, Grant W.
Ko, Minoru S. H.
Gorospe, Myriam
Zou, Sige
Wang, Weidong
TI Top3 beta is an RNA topoisomerase that works with fragile X syndrome
protein to promote synapse formation
SO NATURE NEUROSCIENCE
LA English
DT Article
ID MENTAL-RETARDATION PROTEIN; FOCAL ADHESION KINASE; MESSENGER-RNA;
III-ALPHA; DNA-DAMAGE; STRESS GRANULES; DROSOPHILA; FMRP; SCHIZOPHRENIA;
TRANSLATION
AB Topoisomerases are crucial for solving DNA topological problems, but they have not been linked to RNA metabolism. Here we show that human topoisomerase 3 beta (Top3 beta) is an RNA topoisomerase that biochemically and genetically interacts with FMRP, a protein that is deficient in fragile X syndrome and is known to regulate the translation of mRNAs that are important for neuronal function, abnormalities of which are linked to autism. Notably, the FMRP-Top3 beta interaction is abolished by a disease-associated mutation of FMRP, suggesting that Top3 beta may contribute to the pathogenesis of mental disorders. Top3 beta binds multiple mRNAs encoded by genes with neuronal functions linked to schizophrenia and autism. Expression of one such gene, that encoding protein tyrosine kinase 2 (ptk2, also known as focal adhesion kinase or FAK), is reduced in the neuromuscular junctions of Top3 beta mutant flies. Synapse formation is defective in Top3 beta mutant flies and mice, as well as in FMRP mutant flies and mice. Our findings suggest that Top3 beta acts as an RNA topoisomerase and works with FMRP to promote the expression of mRNAs that are crucial for neurodevelopment and mental health.
C1 [Xu, Dongyi; Shen, Weiping; Guo, Rong; Xue, Yutong; Peng, Wei; Yang, Jiandong; Fox, David, III; Wang, Weidong] NIA, Genome Instabil & Chromatin Remodeling Sect, NIH, Baltimore, MD 21224 USA.
[Xu, Dongyi] Peking Univ, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China.
[Sima, Jian] NIA, Human Genet Sect, NIH, Baltimore, MD 21224 USA.
[Yang, Jay; Brown, Grant W.] Univ Toronto, Dept Biochem, Toronto, ON, Canada.
[Sharov, Alexei; Qian, Yong; Piao, Yulan; Ko, Minoru S. H.] NIA, Dev Genom & Aging Sect, NIH, Baltimore, MD 21224 USA.
[Srikantan, Subramanya; Martindale, Jennifer L.; Gorospe, Myriam] NIA, RNA Regulat Sect, Genet Lab, NIH, Baltimore, MD 21224 USA.
[Machamer, James; Lloyd, Thomas E.] Johns Hopkins Univ, Sch Med, Dept Neurol & Neurosci, Baltimore, MD USA.
[Joshi, Samit R.; Mohanty, Subhasis; Shaw, Albert C.] Yale Univ, Sch Med, Dept Internal Med, Infect Dis Sect, New Haven, CT 06510 USA.
[Zou, Sige] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA.
RP Zou, SG (reprint author), NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA.
EM zous@mail.nih.gov; wangw@grc.nia.nih.gov
FU Intramural Research Program of the NIA [Z01 AG000657-08]; NIH; Johns
Hopkins Center for Neuroscience Research [NS050274]; Canadian Institutes
of Health research grant [MOP-79368]; National Basic Research Program of
China [2013CB911002]; National Natural Science Foundation of China
[31271435]
FX We thank T. Hsieh (Duke University) for Drosophila Top3 beta reagents;
J.C. Wang (Harvard University) for Top3 beta knockout mice; D. Zarnescu
(University of Illinois), T. Jongens (University of Pennsylvania) and G.
Dreyfuss (University of Pennsylvania) for dfmr1 fly strains and
antibodies; S. Warren (Emory University), S. Ceman (University of
Illinois) and Y. Feng (Emory University) for vectors of FMR1 variants;
U. Fischer (University of Wuerzburg) for vectors of TDRD3 and FMR1
orthologs; A. Hoogeveen (Erasmus University) for FXR1 and FXR2
antibodies; R. Hynes (Massachusetts Institute of Technology) and R.
Palmer (Umea University) for FAK reagents; T. Enomoto (Tohoku
University) for Top3b-/-DT40 cells; and R. Hanai (Rikkyo
University) for the Top3 beta vector. We thank E. Chen, D.J. Pan and Y.
Feng for advice and assistance, S. K. Lee for assistance and D.
Schlessinger for support and critical reading of the manuscript. This
work is supported in part by the Intramural Research Program of the NIA
(Z01 AG000657-08), the NIH, the Johns Hopkins Center for Neuroscience
Research (NS050274), Canadian Institutes of Health research grant
MOP-79368 (to G. W. B.), the National Basic Research Program of China
(2013CB911002) and the National Natural Science Foundation of China
(31271435). This study used the high-performance computational
capabilities of the Biowulf Linux cluster at the NIH, Bethesda,
Maryland, USA (http://biowulf.nih.gov).
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NR 63
TC 17
Z9 18
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1097-6256
J9 NAT NEUROSCI
JI Nat. Neurosci.
PD SEP
PY 2013
VL 16
IS 9
BP 1238
EP U112
DI 10.1038/nn.3479
PG 13
WC Neurosciences
SC Neurosciences & Neurology
GA 207KN
UT WOS:000323597500015
PM 23912945
ER
PT J
AU Lindell, AK
Hudry, K
AF Lindell, Annukka K.
Hudry, Kristelle
TI Atypicalities in Cortical Structure, Handedness, and Functional
Lateralization for Language in Autism Spectrum Disorders
SO NEUROPSYCHOLOGY REVIEW
LA English
DT Review
DE Language; Autism spectrum disorders; Brain; Asymmetry; Hemisphere;
Review
ID EARLY INFANTILE-AUTISM; HEMISPHERIC ASYMMETRIES; PLANUM TEMPORALE; HAND
PREFERENCE; CEREBRAL LATERALIZATION; BRAIN ABNORMALITIES; ASSOCIATION
CORTEX; CHILDHOOD AUTISM; CHILDREN; SPEECH
AB Language is typically a highly lateralized function, with atypically reduced or reversed lateralization linked to language impairments. Given the diagnostic and prognostic role of impaired language for autism spectrum disorders (ASDs), this paper reviews the growing body of literature that examines patterns of lateralization in individuals with ASDs. Including research from structural and functional imaging paradigms, and behavioral evidence from investigations of handedness, the review confirms that atypical lateralization is common in people with ASDs. The evidence indicates reduced structural asymmetry in fronto-temporal language regions, attenuated functional activation in response to language and pre-linguistic stimuli, and more ambiguous (mixed) hand preferences, in individuals with ASDs. Critically, the evidence emphasizes an intimate relationship between atypical lateralization and language impairment, with more atypical asymmetries linked to more substantive language impairment. Such evidence highlights opportunities for the identification of structural and functional biomarkers of ASDs, affording the potential for earlier diagnosis and intervention implementation.
C1 [Lindell, Annukka K.] La Trobe Univ, Sch Psychol Sci, Melbourne, Vic 3086, Australia.
[Hudry, Kristelle] La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Melbourne, Vic 3086, Australia.
RP Lindell, AK (reprint author), La Trobe Univ, Sch Psychol Sci, Melbourne, Vic 3086, Australia.
EM a.lindell@latrobe.edu.au
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World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 109
TC 7
Z9 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1040-7308
EI 1573-6660
J9 NEUROPSYCHOL REV
JI Neuropsychol. Rev.
PD SEP
PY 2013
VL 23
IS 3
BP 257
EP 270
DI 10.1007/s11065-013-9234-5
PG 14
WC Psychology, Clinical; Neurosciences
SC Psychology; Neurosciences & Neurology
GA 209EY
UT WOS:000323738400004
PM 23649809
ER
PT J
AU Salafia, C
Girardi, T
Yampolsky, M
Shlakhter, O
Newschaffer, C
Fallin, D
Walker, C
Stodgell, CJ
Katzman, PJ
Culhane, J
Landrigan, P
Szabo, S
Thieux, N
Swanson, J
Dole, N
Varner, MW
Moye, J
Miller, R
AF Salafia, Carolyn
Girardi, Theresa
Yampolsky, Michael
Shlakhter, Oleksandr
Newschaffer, Craig
Fallin, Danielle
Walker, Cheryl
Stodgell, C. J.
Katzman, P. J.
Culhane, J.
Landrigan, P.
Szabo, S.
Thieux, N.
Swanson, J.
Dole, N.
Varner, M. W.
Moye, John
Miller, Richard
TI CHORIONIC VASCULAR STRUCTURE AND PLACENTAL FUNCTIONAL EFFICIENCY (BETA)
DIFFER IN HIGH AND LOW AUTISM RISK PLACENTAL COHORTS
SO PLACENTA
LA English
DT Meeting Abstract
CT Annual Meeting of the International-Federation-of-Placenta-Associations
(IFPA)
CY SEP 11-14, 2013
CL Whistler, CANADA
SP Int Federat Placenta Assoc (IFPA)
C1 [Salafia, Carolyn; Girardi, Theresa; Yampolsky, Michael] Placental Analyt LLC, Larchmont, NY USA.
[Salafia, Carolyn; Girardi, Theresa] New York State Off Mental Retardat & Dev Disabil, Inst Basic Res, Staten Isl, NY USA.
[Yampolsky, Michael; Shlakhter, Oleksandr] Univ Toronto, Toronto, ON, Canada.
[Shlakhter, Oleksandr] Alberta Hlth Serv, Edmonton, AB, Canada.
[Newschaffer, Craig] Drexel Univ, Philadelphia, PA 19104 USA.
[Fallin, Danielle] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Walker, Cheryl] Univ Calif Davis, Davis, CA 95616 USA.
[Stodgell, C. J.; Katzman, P. J.; Culhane, J.; Landrigan, P.; Szabo, S.; Thieux, N.; Swanson, J.; Dole, N.; Varner, M. W.; Moye, John; Miller, Richard] Natl Childrens Study Placenta Consortium, Bethesda, MD USA.
[Stodgell, C. J.; Katzman, P. J.; Miller, Richard] Univ Rochester, Sch Med & Dent, Rochester, NY USA.
[Culhane, J.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Landrigan, P.] Mt Sinai Sch Med, New York, NY USA.
[Szabo, S.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
[Thieux, N.] S Dakota State Univ, Brookings, SD 57007 USA.
[Swanson, J.] Univ Calif Irvine, Irvine, CA USA.
[Dole, N.] Univ N Carolina, Chapel Hill, NC USA.
[Varner, M. W.] Univ Utah, Salt Lake City, UT USA.
[Moye, John] NIH, Natl Childrens Study, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0143-4004
J9 PLACENTA
JI Placenta
PD SEP
PY 2013
VL 34
IS 9
BP A72
EP A72
DI 10.1016/j.placenta.2013.06.217
PG 1
WC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
SC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
GA 207GW
UT WOS:000323587900225
ER
PT J
AU Salafia, C
Merz, G
Platt, C
AF Salafia, Carolyn
Merz, George
Platt, Craig
TI PLACENTAL TERMINAL VILLI COMPLEXITY IN CASES OF AUTISM/AUTISM SPECTRUM
DISORDER (ASD) AND THEIR MATCHED CONTROLS
SO PLACENTA
LA English
DT Meeting Abstract
CT Annual Meeting of the International-Federation-of-Placenta-Associations
(IFPA)
CY SEP 11-14, 2013
CL Whistler, CANADA
SP Int Federat Placenta Assoc (IFPA)
C1 [Salafia, Carolyn; Merz, George] New York State Off Mental Retardat & Dev Disabil, Inst Basic Res, Staten Isl, NY USA.
[Salafia, Carolyn] Placental Analyt LLC, Larchmont, NY USA.
[Platt, Craig] Univ Hosp Bristol NHS Fdn Trust, Bristol, Avon, England.
RI Platt, Craig/C-5137-2012
NR 0
TC 0
Z9 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0143-4004
J9 PLACENTA
JI Placenta
PD SEP
PY 2013
VL 34
IS 9
BP A13
EP A14
DI 10.1016/j.placenta.2013.06.043
PG 2
WC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
SC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
GA 207GW
UT WOS:000323587900052
ER
PT J
AU Egawa, J
Watanabe, Y
Endo, T
Someya, T
AF Egawa, Jun
Watanabe, Yuichiro
Endo, Taro
Someya, Toshiyuki
TI Association of rs2129575 in the tryptophan hydroxylase 2 gene with
clinical phenotypes of autism spectrum disorders
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Letter
ID POLYMORPHISMS
C1 [Egawa, Jun; Watanabe, Yuichiro; Endo, Taro; Someya, Toshiyuki] Niigata Univ, Grad Sch Med & Dent Sci, Dept Psychiat, Niigata, Japan.
RP Egawa, J (reprint author), Niigata Univ, Grad Sch Med & Dent Sci, Dept Psychiat, Niigata, Japan.
EM yuichiro@med.niigata-u.ac.jp
CR Booij L, 2012, MOL PSYCHIATR, V17, P809, DOI 10.1038/mp.2011.79
Egawa J, 2012, PSYCHIAT RES, V196, P320, DOI 10.1016/j.psychres.2011.09.001
KURITA H, 1989, J AUTISM DEV DISORD, V19, P389, DOI 10.1007/BF02212937
Yang SY, 2012, NEUROSCI RES, V73, P333, DOI 10.1016/j.neures.2012.05.012
Zafeiriou DI, 2009, CURR NEUROPHARMACOL, V7, P150, DOI 10.2174/157015909788848848
NR 5
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD SEP
PY 2013
VL 67
IS 6
BP 457
EP 458
DI 10.1111/pcn.12080
PG 2
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 209BH
UT WOS:000323728100012
PM 23992289
ER
PT J
AU Lopata, C
Thomeer, ML
Volker, MA
Lee, GK
Smith, TH
Rodgers, JD
Smith, RA
Gullo, G
McDonald, CA
Mirwis, J
Toomey, JA
AF Lopata, Christopher
Thomeer, Marcus L.
Volker, Martin A.
Lee, Gloria K.
Smith, Tristram H.
Rodgers, Jonathan D.
Smith, Rachael A.
Gullo, Gaetano
McDonald, Christin A.
Mirwis, Joshua
Toomey, Jennifer A.
TI Open-Trial Pilot Study of a Comprehensive School-Based Intervention for
High-Functioning Autism Spectrum Disorders
SO REMEDIAL AND SPECIAL EDUCATION
LA English
DT Article
DE manualized treatment; comprehensive school-based intervention; social
skills intervention; high-functioning autism spectrum disorders
ID SOCIAL-SKILLS INTERVENTIONS; ASPERGERS-SYNDROME; PSYCHOSOCIAL
INTERVENTIONS; CHILDREN; INDIVIDUALS; ADOLESCENTS; HFASD
AB There is a notable lack of manualized comprehensive school-based interventions (CSBIs) for children with high-functioning autism spectrum disorders (HFASDs). This pilot study examined the feasibility and initial efficacy of a CSBI for 12 children with HFASDs, aged 6 to 9 years. Treatment included a 3-week summer preparation program followed by a 10-month CSBI, composed of social skills groups, therapeutic activities, face and voice emotion recognition instruction, an individual daily note, and parent training. Feasibility was supported in high levels of treatment fidelity and teacher- and parent-reported acceptability and satisfaction. Pre-post comparisons suggested that children significantly improved their knowledge of target social skills and ability to identify emotions in facial and vocal expressions. According to parent and teacher ratings, children displayed gains in their use of target social skills and broader social performance, as well as reductions in ASD-related features.
C1 [Lopata, Christopher; Thomeer, Marcus L.] Canisius Coll, Inst Autism Res, Buffalo, NY 14208 USA.
[Volker, Martin A.; Lee, Gloria K.; Rodgers, Jonathan D.; Smith, Rachael A.; Gullo, Gaetano; McDonald, Christin A.; Mirwis, Joshua] SUNY Buffalo, Buffalo, NY 14260 USA.
[Smith, Tristram H.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA.
[Toomey, Jennifer A.] Summit Educ Resources, Getzville, NY USA.
RP Lopata, C (reprint author), Inst Autism Res, HS-216,2001 Main St, Buffalo, NY 14208 USA.
EM lopatac@canisius.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Baron-Cohen S., 2004, MIND READING INTERAC
Bauminger N, 2007, J AUTISM DEV DISORD, V37, P1593, DOI 10.1007/s10803-006-0245-4
Bauminger N, 2007, J AUTISM DEV DISORD, V37, P1605, DOI 10.1007/s10803-006-0246-3
Bellini S, 2007, REM SPEC EDUC, V28, P153, DOI 10.1177/07419325070280030401
Carrow-Woolfolk E, 1999, COMPREHENSIVE ASSESS
Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
Cohen J., 1988, STAT POWER ANAL BEHA, V2nd
Constantino JN, 2005, SOCIAL RESPONSIVENES
ELLIOTT SN, 1991, J SCHOOL PSYCHOL, V29, P43, DOI 10.1016/0022-4405(91)90014-I
Frankel F, 2010, J AUTISM DEV DISORD, V40, P827, DOI 10.1007/s10803-009-0932-z
Golan O., 2012, CAMBRIDGE MIND UNPUB
Goldstein A. P., 1997, SKILLSTREAMING ADOLE
Koenig K, 2010, J AUTISM DEV DISORD, V40, P1209, DOI 10.1007/s10803-010-0979-x
Lindner JL, 2006, J AUTISM DEV DISORD, V36, P769, DOI 10.1007/s10803-006-0105-2
Lopata C., 2008, SCH PSYCHOL 21 CENTU, P299
Lopata C, 2010, J AUTISM DEV DISORD, V40, P1297, DOI 10.1007/s10803-010-0989-8
Lopata C, 2008, J AUTISM DEV DISORD, V38, P890, DOI 10.1007/s10803-007-0460-7
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McGinnis E., 1997, SKILLSTREAMING ELEME
Nowicki S., 1997, INSTRUCTIONAL MANUAL, V2
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Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd
Rutter M., 2003, AUTISM DIAGNOSTIC IN
Scarpa A., COGNITIVE BEHAV INTE
Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
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Thomeer M. L., PSYCHOL SCH IN PRESS
Toomey J. A., 2009, SPECIAL ED 21 CENTUR, P95
Volkmar F. R., 2000, ASPERGER SYNDROME, P340
Wechsler D., 2003, WECHSLER INTELLIGENC
White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
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White SW, 2010, FOCUS AUTISM DEV DIS, V25, P209, DOI 10.1177/1088357610380595
NR 39
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0741-9325
J9 REM SPEC EDUC
JI Remedial Spec. Educ.
PD SEP
PY 2013
VL 34
IS 5
BP 269
EP 281
DI 10.1177/0741932512450518
PG 13
WC Education, Special
SC Education & Educational Research
GA 207YU
UT WOS:000323641700002
ER
PT J
AU Causin, KG
Albert, KM
Carbone, VJ
Sweeney-Kerwin, EJ
AF Causin, Kaitlin G.
Albert, Kristin M.
Carbone, Vincent J.
Sweeney-Kerwin, Emily J.
TI The role of joint control in teaching listener responding to children
with autism and other developmental disabilities
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Joint control; Listener behavior; Verbal behavior
ID BEHAVIOR
AB This study evaluated the effectiveness of a teaching procedure derived from the analysis of joint control in increasing listener responses for three children with autism using a multiple probe design across participants. One nonvocal and two vocal children with autism were taught to select multiple pictures of items from a large array in the order in which they were requested (e.g., "Give me the ball, cup, and spoon") using the joint control teaching procedure. The effect of these procedures on the emission of accurate selection responses to both trained and novel stimulus sets was measured. The results indicated that listener responses to trained stimuli increased following the implementation of the independent variable and untrained responses across novel stimulus sets also emerged. Implications for designing language training programs for children with autism based on an analysis of joint control are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Causin, Kaitlin G.; Albert, Kristin M.; Carbone, Vincent J.; Sweeney-Kerwin, Emily J.] Carbone Clin, Valley Cottage, NY 10989 USA.
RP Carbone, VJ (reprint author), Carbone Clin, 614 Corp Way,Suite 1, Valley Cottage, NY 10989 USA.
EM drvjc@aol.com
CR Bondy A., 2002, THE PICTURE EXCHANGE
degli Espinosa F., 2011, THESIS
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Lowenkron B, 1996, J EXP ANAL BEHAV, V65, P252, DOI 10.1901/jeab.1996.65-252
Lowenkron B, 1992, Anal Verbal Behav, V10, P1
Lowenkron Barry, 2004, Anal Verbal Behav, V20, P77
Lowenkron B., 2006, ANAL VERBAL BEHAV, V22, P129
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Lowenkron Barry, 2006, Anal Verbal Behav, V22, P123
Lowenkron B, 1995, Anal Verbal Behav, V12, P13
Michael Jack, 2011, Anal Verbal Behav, V27, P3
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Smith T., 2001, FOCUS AUTISM OTHER D, V16, P86, DOI 10.1177/108835760101600204
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Sundberg M. L., 2008, VB MAPP VERBAL BEHAV
Sundberg ML, 2001, BEHAV MODIF, V25, P698, DOI 10.1177/0145445501255003
NR 27
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 997
EP 1011
DI 10.1016/j.rasd.2013.04.011
PG 15
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400001
ER
PT J
AU Peters-Scheffer, N
Didden, R
Mulders, M
Korzilius, H
AF Peters-Scheffer, Nienke
Didden, Robert
Mulders, Monique
Korzilius, Hubert
TI Effectiveness of low intensity behavioral treatment for children with
autism spectrum disorder and intellectual disability
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Applied Behavior Analysis; Autism spectrum disorder; Intervention;
Discrete trial training; Intellectual disability
ID YOUNG-CHILDREN; CLINICAL-SIGNIFICANCE; CONVERGENT VALIDITY;
MENTAL-RETARDATION; INTERVENTION; PRESCHOOL; PARENTS; QUESTIONNAIRE;
FLEXIBILITY; RELIABILITY
AB To determine the effectiveness of low intensity behavioral treatment (LIBT) supplementing regular treatment in young children with autism spectrum disorder (ASD) and intellectual disability (ID) standardized tests of cognition, adaptive behavior, interpersonal relations, play, language, characteristics of autism, emotional and behavioral problems, behavioral flexibility, early social communication, and maternal stress were administered in a treatment group (n = 20), receiving 4-10 h LIBT per week and a control group (n = 20) receiving treatment as usual. At baseline, no differences were found between groups (mean chronological age: 5.3 years; mean developmental age: 1.11 years) on several key variables, but after two years of intervention the treatment group outperformed the control group on IQ developmental age, adaptive behavior, interpersonal relations, play and receptive language, and less autistic symptoms were seen in treatment group. Following intervention, no differences between groups were found on expressive language, behavioral flexibility and maternal stress. Progress in developmental age, adaptive behavior, interpersonal relations, play and receptive and expressive language was clinically and reliably significant for the majority of the LIBT group. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Peters-Scheffer, Nienke; Didden, Robert] Radboud Univ Nijmegen, Inst Behav Sci, NL-6500 HE Nijmegen, Netherlands.
[Peters-Scheffer, Nienke; Mulders, Monique] Stichting Driestroom, NL-6660 AC Elst, Netherlands.
[Didden, Robert] Trajectum, NL-7200 AH Zutphen, Netherlands.
[Korzilius, Hubert] Radboud Univ Nijmegen, Inst Management Res, NL-6500 HE Nijmegen, Netherlands.
RP Peters-Scheffer, N (reprint author), Radboud Univ Nijmegen, Inst Behav Sci, POB 9104, NL-6500 HE Nijmegen, Netherlands.
EM n.peters@pwo.ru.nl
CR Achenbach T, 2000, MANUAL ASEBA PRESCHO
American Psychiatric Association (APA), 2000, DIAGNOSTIC AND STATI
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de Bildt A, 2005, J AUTISM DEV DISORD, V35, P53, DOI 10.1007/s10803-004-1033-7
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NR 71
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1012
EP 1025
DI 10.1016/j.rasd.2013.05.001
PG 14
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400002
ER
PT J
AU Taubman, MT
Leaf, RB
McEachin, JJ
Papovich, S
Leaf, JB
AF Taubman, Mitchell T.
Leaf, Ronald B.
McEachin, John J.
Papovich, Sasha
Leaf, Justin B.
TI A comparison of data collection techniques used with discrete trial
teaching
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Data; Data collection; Measurement; Time sample; Trial by trial
ID PARTIAL-INTERVAL; AUTISM; CHILDREN
AB This study was designed to examine the comparative value of three discrete trial teaching data collection techniques: Continuous recording, time sample, and estimation. The data collection was conducted by behavior interventionists while teaching children diagnosed with autism spectrum disorder skills using discrete trial teaching. Utilizing a counterbalanced design, data collection techniques were examined in regards to their accuracy, that is, their correspondence to the independent measurement of a primary observer collecting contemporaneous trial-by-trial data. Also assessed were the relative impacts of the various techniques on efficiency of therapy and rate of children's acquisition. Finally, interventionists rated their preference of and satisfaction with each of the three techniques. Continuous recording was generally the most accurate, although the other methods were accurate to a degree when used by trained recorders to justify their usage in applied settings. Estimation was the most efficient and time sample was the most preferred. (C) 2013 Elsevier Ltd. All rights reserved.
RP Leaf, JB (reprint author), BCBA D, 200 Marina Dr, Seal Beach, CA 90740 USA.
EM Jblautpar@aol.com
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NR 19
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1026
EP 1034
DI 10.1016/j.rasd.2013.05.002
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400003
ER
PT J
AU Kuhlthau, K
Kovacs, E
Hall, T
Clemmons, T
Orlich, F
Delahaye, J
Sikora, D
AF Kuhlthau, Karen
Kovacs, Erica
Hall, Trevor
Clemmons, Traci
Orlich, Felice
Delahaye, Jennifer
Sikora, Darryn
TI Health-related quality of life for children with ASD: Associations with
behavioral characteristics
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Health-related quality of life; Behavior
ID AUTISM SPECTRUM DISORDERS; INTELLECTUAL DISABILITY; PSYCHOMETRIC
PROPERTIES; PSYCHIATRIC-PROBLEMS; ASPERGER-SYNDROME; CONCEPTUAL-MODEL;
PARENT REPORT; RATING-SCALE; ADOLESCENTS; CHECKLIST
AB This paper examines health-related quality of life (HRQoL) of children age 6-11 years with an autism spectrum disorder (ASD) using the Child Health and Illness Profile - Child Edition (CHIP-CE). We further examine associations of HRQoL scores with measures of behavior using regression models. Overall HRQoL scores are lower than those for normative samples. We find that both externalizing and internalizing behaviors (measured with the Child Behavior Checklist) are correlated with HRQoL as are several of the subscales of the aberrant behavior checklist. These results suggest that some potentially modifiable aspects of ASD, in particular ASD-related and aberrant behaviors, are associated with HRQoL. These associations are suggestive of the potential for improvements in behaviors in some domains having the potential to improve HRQoL. Future studies should determine whether improvements in behaviors are associated with improvements in HRQoL. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Kuhlthau, Karen] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02114 USA.
[Kuhlthau, Karen; Delahaye, Jennifer] Massachusetts Gen Hosp, Ctr Child & Adolescent Hlth Res & Policy, Boston, MA 02114 USA.
[Kovacs, Erica] Columbia Univ, Med Ctr, New York, NY 10027 USA.
[Orlich, Felice] Seattle Childrens Hosp, Seattle, WA USA.
[Sikora, Darryn] Providence Neurodev Ctr Children Providence Hlth, Providence, RI USA.
RP Kuhlthau, K (reprint author), Harvard Univ, Sch Med, Dept Pediat, 100 Cambridge St,15th Floor, Boston, MA 02114 USA.
EM kkuhlthau@partners.org
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NR 41
TC 4
Z9 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1035
EP 1042
DI 10.1016/j.rasd.2013.04.006
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400004
ER
PT J
AU Louwerse, A
van der Geest, JN
Tulen, JHM
van der Ende, J
Van Gool, AR
Verhulst, FC
Greaves-Lord, K
AF Louwerse, A.
van der Geest, J. N.
Tulen, J. H. M.
van der Ende, J.
Van Gool, A. R.
Verhulst, F. C.
Greaves-Lord, K.
TI Effects of eye gaze directions of facial images on looking behaviour and
autonomic responses in adolescents with autism spectrum disorders
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Eyes; Gaze direction; Eye-tracking; Heart
rate; Skin conductance response
ID HIGH-FUNCTIONING AUTISM; PHYSIOLOGICAL REACTIVITY;
DEVELOPMENTAL-CHANGES; ATYPICAL DEVELOPMENT; FACE RECOGNITION; YOUNG
INFANTS; CHILDREN; CONTACT; EMOTION; INDIVIDUALS
AB It has been suggested that atypical eye contact of individuals with autism spectrum disorders (ASDs) arises from an unusually high level of autonomic activity elicited by another person's gaze. The present study investigated visual fixation duration and autonomic reactivity (heart rate, skin conductance response) simultaneously, while adolescents looked towards photographs of neutral faces, with either direct eye gaze, averted eye gaze or closed eyes. Both cognitively able adolescents with ASD (n = 31, mean age = 16 years, mean IQ = 104) and typically developing (TD) adolescents (n = 34, mean age = 16 years, mean IQ = 108) looked significantly longer towards the eye region of faces with direct eye gaze compared with faces with averted eye gaze or closed eyes. The adolescents with ASD did not show higher levels of autonomic activity than TD adolescents while they were instructed to look at the eye region. This suggests that looking at the eye region of static faces does not particularly trigger high autonomic arousal in adolescents with ASD. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Louwerse, A.; van der Ende, J.; Greaves-Lord, K.] Erasmus MC Sophia, Dept Child & Adolescent Psychiat Psychol, NL-3015 CN Rotterdam, Netherlands.
[Louwerse, A.; Van Gool, A. R.; Greaves-Lord, K.] Org Mental Hlth, Yulius Acad, Yulius, NL-3013 HH Rotterdam, Netherlands.
[Tulen, J. H. M.] Erasmus MC, Dept Neurosci, NL-3015 GE Rotterdam, Netherlands.
[Tulen, J. H. M.] Erasmus MC, Dept Psychiat, NL-3015 CE Rotterdam, Netherlands.
RP Louwerse, A (reprint author), Erasmus MC Sophia, Dept Child & Adolescent Psychiat Psychol, Wytemaweg 8, NL-3015 CN Rotterdam, Netherlands.
EM s.louwerse@erasmusmc.nl; j.vandergeest@erasmusmc.nl;
j.h.m.tulen@erasmusmc.nl; jan.vanderende@erasmusrnc.nl;
a.vangool@yulius.nl; f.verhulst@erasmusmc.nl;
k.greaves-lord@erasmusmc.nl
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NR 49
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1043
EP 1053
DI 10.1016/j.rasd.2013.04.013
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400005
ER
PT J
AU Movahedi, A
Bahrami, F
Marandi, SM
Abedi, A
AF Movahedi, Ahmadreza
Bahrami, Fatimah
Marandi, Sayed Mohammad
Abedi, Ahmad
TI Improvement in social dysfunction of children with autism spectrum
disorder following long term Kata techniques training
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Social interaction; Autism; Karate; Exercise
ID SELF-STIMULATORY BEHAVIOR; HIGH-FUNCTIONING CHILDREN; STEREOTYPIC
BEHAVIORS; SKILLS INTERVENTIONS; ANTECEDENT EXERCISE; SEROTONIN
SYNTHESIS; MENTAL-RETARDATION; PHYSICAL-ACTIVITY; ASPERGER-SYNDROME;
ADOLESCENTS
AB The purpose of the present study was to investigate the effects of long term Kata techniques training on social interaction of children with autism spectrum disorders (ASD). We assigned 30 school aged children with ASD to an exercise (n = 15) or a no-exercise group (n = 15). We required participants of the exercise group to exercise Kata techniques for 14 weeks, while participants of the control group received no exercise. We evaluated the social interaction of the participants at baseline, post-intervention (week 14), and at one month follow up. Results revealed that Kata techniques training significantly improved social dysfunction in the exercise group. Interestingly, at one month follow up improvement in social deficiency in the exercise group remained unchanged compared to post-intervention time. The social deficiency of participants of the control group was not changed across the experimental period. We concluded that teaching martial arts techniques to children with ASD leads to significant improvement in their social interaction. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Movahedi, Ahmadreza; Bahrami, Fatimah; Marandi, Sayed Mohammad] Univ Isfahan, Coll Sport Sci, Esfahan, Iran.
[Abedi, Ahmad] Univ Isfahan, Coll Educ Psychol, Esfahan, Iran.
RP Bahrami, F (reprint author), Univ Isfahan, Coll Sport Sci, HezarJarib St, Esfahan, Iran.
EM fbahrami20@yahoo.com
RI McCann, Brian/N-9504-2014
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NR 90
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1054
EP 1061
DI 10.1016/j.rasd.2013.04.012
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400006
ER
PT J
AU Chaput, V
Amsellem, F
Urdapilleta, I
Chaste, P
Leboyer, M
Delorme, R
Gousse, V
AF Chaput, Valerie
Amsellem, Frederique
Urdapilleta, Isabel
Chaste, Pauline
Leboyer, Marion
Delorme, Richard
Gousse, Veronique
TI Episodic memory and self-awareness in Asperger Syndrome: Analysis of
memory narratives
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Episodic memory; Asperger Syndrome; Self-awareness; Autonoetic
consciousness; Theory of mind
ID HIGH-FUNCTIONING AUTISM; AUTOBIOGRAPHICAL MEMORY; DIAGNOSTIC INTERVIEW;
AUTONOETIC CONSCIOUSNESS; ADULTS; CHILDREN; VALIDATION; DISORDERS;
EMOTIONS; SPECTRUM
AB Previous findings from researchers on individuals with Asperger Syndrome (AS) suggest peculiarities of autobiographical memory (AM). They have shown a personal episodic memory deficit in the absence of a personal semantic memory impairment. The primary aim of this study was to explore AM in individuals with AS, and more specifically to investigate the link between episodic memory, self-awareness, and autonoetic consciousness through language analysis. We asked fifteen adults with AS and fifteen age- and IQ-matched controls to recall autobiographical memories from three life periods. Recorded interviews were processed using Alceste software. We found that participants with AS recalled fewer and less-detailed episodic memories than did controls. A content analysis revealed that family-related vocabulary as well as possessive pronouns was significantly less frequent in AS interviews than in those of controls. In conclusion, our results support the hypothesis that a deficiency of episodic memory may be due to poor awareness of the self in social relationships. Reduced use of possessive pronouns may also indicate less self-investment in life experiences, which would in turn impact recall. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Chaput, Valerie; Amsellem, Frederique; Delorme, Richard] Inst Pasteur, F-75015 Paris, France.
[Chaput, Valerie; Amsellem, Frederique; Delorme, Richard] Fdn Fondamental, Hop Robert Debre, INSERM U955, F-75935 Paris 19, France.
[Urdapilleta, Isabel] Univ Paris 08, Lab Parisien Psychol Sociale LAPPS, Equipe Rech Parole & Pensee Sociale, EA4386, F-93526 St Denis 02, France.
[Chaste, Pauline; Leboyer, Marion] Fdn Fondamental, Inst Mondor Rech Biomed, Pole Psychiat Hop Chenevier INSERM U955, F-94010 Creteil, France.
[Gousse, Veronique] UNIMES Aix Marseille Univ, Lab Psychol Sociale EA 489, F-30021 Nimes 1, France.
RP Chaput, V (reprint author), Hop Robert Debre, INSERM U955, Equipe 15, 48 Blvd Serurier, F-75019 Paris, France.
EM valerie.chaput@gmail.com
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NR 38
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1062
EP 1067
DI 10.1016/j.rasd.2013.05.005
PG 6
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400007
ER
PT J
AU Konst, MJ
Matson, JL
Turygin, N
AF Konst, Matthew J.
Matson, Johnny L.
Turygin, Nicole
TI Exploration of the correlation between autism spectrum disorder
symptomology and tantrum behaviors
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Tantrum behavior; Autism Spectrum Disorders -
Comorbidity for Children (ASD-CC); Comorbidity
ID PERVASIVE DEVELOPMENTAL DISORDERS; CHILDREN ASD-CC; CHALLENGING
BEHAVIORS; PSYCHIATRIC-DISORDERS; LEARNING-DISABILITIES; EMOTIONAL
COMPETENCE; ASPERGERS SYNDROME; TEMPER TANTRUMS; YOUNG-CHILDREN;
PSYCHOPATHOLOGY
AB The purpose of the current study was to investigate the relationship between the presence of Autism Spectrum Disorder (ASD) symptoms and tantrum behaviors in 598 children ranging in age from two to sixteen years old who meet cutoffs for ASD. Diagnostic categories created in the current study were provided by the Autism Spectrum Disorder - Diagnostic Child Version (ASD-DC). Initial analysis replicated previous research revealing significant differences in the expression of tantrum behavior between the ASD, Atypical, and Normal groups. Pearson Bivariate correlations were then computed for each individual's ASD symptom score and their total score on the Tantrum behavior subscale. Follow-up correlations found significant positive correlations between individual's in the Atypical, Normal, and ASD categories and their scores for the Tantrum behavior subscale of the Autism Spectrum Disorders - Comorbidity for Children (ASD-CC). Post hoc analyses revealed that the correlation between ASD symptomology and tantrum behaviors in the Normal group was significantly different when compared to children in the ASD group. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Konst, Matthew J.; Matson, Johnny L.; Turygin, Nicole] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Konst, MJ (reprint author), LSU, Dept Psychol, Baton Rouge, LA 70803 USA.
EM mkonst1@tigers.lsu.edu
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Tureck K, 2013, DEV NEUROREHABIL, V16, P52, DOI 10.3109/17518423.2012.719245
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NR 77
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1068
EP 1074
DI 10.1016/j.rasd.2013.05.006
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400008
ER
PT J
AU Zakas, TL
Browder, DM
Ahlgrim-Delzell, L
Heafner, T
AF Zakas, Tracie-Lynn
Browder, Diane M.
Ahlgrim-Delzell, Lynn
Heafner, Tina
TI Teaching social studies content to students with autism using a graphic
organizer intervention
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Social studies; History; Graphic organizer; Adapted text;
Single-case design
ID COOPERATIVE LEARNING GROUPS; READING-COMPREHENSION; INTEGRATION
STRATEGY; PEERS; TEXT; INCREASE; LD
AB The National Council for the Social Studies (NCSS) emphasizes the teaching of social studies to provide students with information, critical thinking skills, and experiences to allow them to grow into responsible and effective citizens. There have been few studies focused on social studies instruction for students with autism spectrum disorders or other developmental disabilities. One of the barriers to teaching social studies to students without and with disabilities is students' ability to read and understand written expository text. This current study investigated the use of a modified graphic organizer to promote improved expository text comprehension for middle school students with autism. Three students were instructed to use a modified graphic organizer intervention to answer nine items from United States history passages. Results indicated that each of the three students increased their ability to independently respond to the nine comprehension items. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Zakas, Tracie-Lynn] Charlotte Mecklenburg Sch Syst, Programs Except Children, Charlotte, NC 28202 USA.
[Browder, Diane M.] Univ N Carolina, Dept Special Educ & Child Dev, Charlotte, NC 28223 USA.
[Ahlgrim-Delzell, Lynn] Univ N Carolina, Dept Educ Leadership, Charlotte, NC 28223 USA.
[Heafner, Tina] Univ N Carolina, Dept Middle Secondary & Educ K12, Charlotte, NC 28223 USA.
RP Zakas, TL (reprint author), Charlotte Mecklenburg Sch Syst, Programs Except Children, 700 E Stonewall St,Suite 404, Charlotte, NC 28202 USA.
EM tracie.zakas@cms.k12.nc.us; dbrowder@uncc.edu; laahlgri@uncc.edu;
Tina.Heafner@uncc.edu
CR Boulineau T, 2004, LEARN DISABILITY Q, V27, P105, DOI 10.2307/1593645
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Gast D. L., 2010, SINGLE SUBJECT RES M
Harcourt, 2003, HOR US CAN MEX CENTR
Homer R. H., 2005, EXCEPT CHILDREN, V71, P165
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Lexile Framework for Reading, 2011, PASS SEARCH
Marzano R. J., 2004, BUILDING BACKGROUND
McCormick T. M., 2008, SOC EDUC, V72, P268
National Council for the Social Studies, 2010, NAT CURR STAND SOC S
National Council for the Social Studies, 2002, NAT STAND SOC STUD T
O'Connor IM, 2004, J AUTISM DEV DISORD, V34, P115, DOI 10.1023/B:JADD.0000022603.44077.6b
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NR 26
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1075
EP 1086
DI 10.1016/j.rasd.2013.06.001
PG 12
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400009
ER
PT J
AU Swanson, MR
Siller, M
AF Swanson, Meghan R.
Siller, Michael
TI Patterns of gaze behavior during an eye-tracking measure of joint
attention in typically developing children and children with autism
spectrum disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Response to joint attention; Gaze following;
Eye-tracking; Endophenotype
ID SOCIAL INFORMATION; VISUAL-ATTENTION; FACES; MOVEMENTS; FIXATION;
LOOKING; HETEROGENEITY; INDIVIDUALS; PERFORMANCE; COMPETENCE
AB This study evaluated whether diagnostic classifications or features of ASD were associated with individual differences in children's gaze pattern during an eye-tracking measure of joint attention. The sample included 21 children with ASD (mean age, 7.3 +/- 1.5 years) and 24 typically developing children (mean age, 6.8 +/- 1.6 years), matched on receptive language abilities. Results revealed no significant group differences on global measures of gaze allocation (total gaze time allocation). However, significant group differences emerged using a measure evaluating a microstructure of children's gaze (duration of first fixation). In addition, individual differences in children's gaze pattern were reliably predicted by parent report measures of children's social abilities. The majority of children in this sample (including all typically developing children and those children with ASD who scored lowest on the SRS Social Awareness subscale) showed significant modulation in eye-gaze between the two experimental conditions. In contrast, children with ASD who also scored the highest on the SRS Social Awareness subscale consistently failed to modulate their eye gaze in accordance with the experimental condition. This failure to flexibly modulate gaze in the context of a joint attention eye-tracking paradigm may reveal children's limited awareness of social cues that may further limit social learning. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Swanson, Meghan R.; Siller, Michael] CUNY, Grad Ctr, Biopsychol & Behav Neurosci Subprogram Psychol, New York, NY 10016 USA.
[Swanson, Meghan R.; Siller, Michael] CUNY Hunter Coll, New York, NY 10065 USA.
RP Swanson, MR (reprint author), CUNY Hunter Coll, Dept Psychol, 695 Pk Ave,Hunter North 611, New York, NY 10065 USA.
EM mswanson@gc.cuny.edu
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NR 40
TC 5
Z9 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1087
EP 1096
DI 10.1016/j.rasd.2013.05.007
PG 10
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400010
ER
PT J
AU Akoury-Dirani, L
Alameddine, M
Salamoun, M
AF Akoury-Dirani, Leyla
Alameddine, Maysam
Salamoun, Mariana
TI Validation of the Lebanese Childhood Autism Rating Scale-Second
Edition-Standard Version
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE CARS2 Standard Version; Validation; Autism; Intellectual disability
ID VALIDITY; RELIABILITY; CARS
AB The purpose of this study is to validate the Childhood Autism Rating Scale-Second Edition-Standard Version (CARS2-ST) to the Lebanese population. The participants consisted of 109 children among which 90 had autism spectrum disorder (ASD) and 19 had intellectual disability (ID). Forward and backward translation was ensured before administration. The Wechsler Nonverbal Scale of Ability (WNV) was used to estimate the level of intellectual functioning. The Lebanese CARS2-ST was found to have a good reliability as measured by internal consistency (.95), inter-rater reliability (.99), and test-retest reliability (.89). It classified individuals as having ASD versus ID based on a cutoff score of 26 or higher for children younger than 13 years old and a cutoff score of 28.5 or higher for adolescents (>= 13 years). A similar level of psychometric properties was found with the original CARS2-ST. Therefore, the Lebanese CARS2-ST is a useful tool for assessing for ASD among the Lebanese population. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Akoury-Dirani, Leyla; Alameddine, Maysam; Salamoun, Mariana] Amer Univ Beirut, Dept Psychiat, Beirut, Lebanon.
RP Akoury-Dirani, L (reprint author), Amer Univ Beirut, Dept Psychiat, Riad El Solh 1107 2020, Beirut, Lebanon.
EM l55@aub.edu.lb; mma72@aub.edu.lb; mma72@aub.edu.lb
CR Akoury-Dirani L., 2013, EARLY CHILD DEV CARE
Alameddine M., 2013, INT J ED PSYCHOL ASS, V13, P64
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Chlebowski C, 2010, J AUTISM DEV DISORD, V40, P787, DOI 10.1007/s10803-009-0926-x
EAVES RC, 1993, J ABNORM CHILD PSYCH, V21, P481, DOI 10.1007/BF00916315
KURITA H, 1989, J AUTISM DEV DISORD, V19, P389, DOI 10.1007/BF02212937
Livanis A., 2010, ASSESSMENT EFFECTIVE, V35, P206
Lord C, 2012, J CHILD PSYCHOL PSYC, V53, P490, DOI 10.1111/j.1469-7610.2012.02547.x
Nordin V, 1998, J AUTISM DEV DISORD, V28, P69, DOI 10.1023/A:1026067104198
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Saemundsen E, 2003, J AUTISM DEV DISORD, V33, P319, DOI 10.1023/A:1024410702242
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Wechsler D., 2006, WECHSLER NONVERBAL S
World Health Organization, 2010, WHO AIMS REP MENT HL
World Health Organization, 2010, ICD 10 INT STAT CLAS
NR 19
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1097
EP 1103
DI 10.1016/j.rasd.2013.05.004
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400011
ER
PT J
AU Cervantes, PE
Matson, JL
Adams, HL
Williams, LW
Goldin, RL
Jang, JN
AF Cervantes, Paige E.
Matson, Johnny L.
Adams, Hilary L.
Williams, Lindsey W.
Goldin, Rachel L.
Jang, Jina
TI Comparing social skill profiles of children with autism spectrum
disorders versus children with attention deficit hyperactivity disorder:
Where the deficits lie
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE ASD; ADHD; Social skills; MESSY-II
ID PERVASIVE DEVELOPMENTAL DISORDER; DEFICIT/HYPERACTIVITY DISORDER;
CHALLENGING BEHAVIORS; LEARNING-DISABILITIES; INFANT SCREEN; PDD-NOS;
ADHD; SYMPTOMS; PSYCHOPATHOLOGY; COMORBIDITY
AB Marked socialization impairment is evident in both individuals with autism spectrum disorders (ASD) and individuals with attention deficit/hyperactivity disorder (ADHD). The current study utilizes the Matson Evaluation of Social Skills for Youngsters-II (MESSY-II) to explore similarities and discrepancies in the social skill profiles of children with ASD and children with ADHD ages 6-9 years old and 10-16 years old. Children with ASD and children with ADHD were both found to be significantly deficient in social skills compared to atypically developing peers without an Axis I or Axis II diagnosis; however, specific skill deficits vary between the groups. In particular, children with ASD exhibited a lack of adaptive social skills whereas children with ADHD demonstrated social skill knowledge but an increased level of maladaptive social behavior. The trends of socialization impairment over time were also found to differ in children with ASD versus children with ADHD. While children with ASD remained at similar levels of adaptive social skill impairment over age groups, children with ADHD were found to become more socially impaired in more areas over time. The distinct patterns and trends of social skill deficit found in children with ASD and children with ADHD can inform treatments targeted toward the specific deficits observed within each disorder. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Cervantes, Paige E.; Matson, Johnny L.; Adams, Hilary L.; Williams, Lindsey W.; Goldin, Rachel L.; Jang, Jina] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Cervantes, PE (reprint author), Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
EM pcerva2@lsu.edu
CR Achenbach TM, 2001, MANUAL CHILD BEHAV C
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NR 47
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1104
EP 1110
DI 10.1016/j.rasd.2013.05.008
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400012
ER
PT J
AU Khowaja, K
Salim, SS
AF Khowaja, Kamran
Salim, Siti Salwah
TI A systematic review of strategies and computer-based intervention (CBI)
for reading comprehension of children with autism
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Review
DE Systematic review; Autism; Computer-based intervention; Reading
comprehension; Vocabulary
ID SPECTRUM DISORDERS; DEVELOPMENTAL DISORDERS; ANIMATED TUTOR;
INSTRUCTION; VOCABULARY; STUDENTS; INDIVIDUALS; LANGUAGE; COMMUNICATION;
ABILITY
AB This paper presents a systematic review of relevant published studies on reading comprehension for children with autism, focusing on vocabulary instruction and text comprehension instruction from years 2000 to 2011. This systematic review attempts to address three specific research questions: strategies of vocabulary instruction and text comprehension instruction used, computer-based intervention (CBI) used or developed during study, and the effectiveness of using CBI for teaching children with autism. There are five strategies of vocabulary instruction and seven strategies of text comprehension instruction. Results indicate that two strategies of vocabulary instruction, multimedia methods and explicit instruction were found to be more commonly used than the other three. On the same note, question answering strategy of text comprehension instruction was discovered to be used more often than the other six. Results also indicate that children with autism can benefit from the strategies of reading comprehension and that the use of CBI as a mode of instruction for reading comprehension improved learning of children. This is clearly evident judging from the performance of children between pre-tests and post-tests of studies in which CBI was used. However, due to heterogeneity of participants, this is not always the case; a few studies reported no improvement in the learning of children with autism. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Khowaja, Kamran; Salim, Siti Salwah] Univ Malaya, Fac Comp Sci & Informat Technol, Kuala Lumpur 50603, Malaysia.
RP Khowaja, K (reprint author), Univ Malaya, Fac Comp Sci & Informat Technol, Kuala Lumpur 50603, Malaysia.
EM kamran.khowaja@siswa.um.edu.my
RI Khowaja, Kamran/A-5003-2014
OI Khowaja, Kamran/0000-0002-0624-2428
CR Anwar A., 2011, ADV LEARN TECHN ICAL
(APA) APA, 2000, DIAGN STAT MAN MENT
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NR 47
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1111
EP 1121
DI 10.1016/j.rasd.2013.05.009
PG 11
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400013
ER
PT J
AU Esther-Ben Itzchak
Aviva, B
Zachor, DA
AF Esther-Ben Itzchak
Aviva, Binet
Zachor, Ditza A.
TI Are special abilities in autism spectrum disorder associated with a
distinct clinical presentation?
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Special abilities; Autism severity symptoms;
Adaptive skills; Head circumference percentile
ID SAVANT SYNDROME; HEAD CIRCUMFERENCE; BRAIN OVERGROWTH; CHILDREN; MEMORY;
INDIVIDUALS; PROFILES; DETAIL; SKILLS
AB Special abilities may be common in autism spectrum disorders (ASD). The aim of this study was to investigate the clinical presentation of ASD with special abilities. Special abilities were defined based on the Autism Diagnostic Interview-Revised (ADI-R). Based on a sample of 398 children, ages 2-7 years old with ASD, 112 with special skills were compared to an age- and gender-matched group without special abilities (n = 79). The examined measures included autism symptoms severity, adaptive behaviors and head circumference percentile. Children with ASD and special abilities seemed to exhibit significantly less impaired ASD symptoms in the social, communication and stereotyped behaviors and significantly better adaptive skills than individuals with ASD without special skills. Children with ASD and special abilities had a larger head circumference percentile than children without special abilities. Special abilities occurred in 28% of the study participants. Memory skills were the most frequently reported special ability, followed by musical, visuospatial and reading skills. The authors conclude that individuals with ASD and special abilities might represent a distinct ASD subgroup with milder clinical ASD presentation. Larger head circumference in ASD was previously associated with enhanced "local" connectivity which provides detailed information processing and therefore might be related to the appearance of special abilities. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Esther-Ben Itzchak; Zachor, Ditza A.] Assaf Harofeh Med Ctr, Autism Ctr, Zerifin, Israel.
[Esther-Ben Itzchak] Ariel Univ, Dept Commun Disorders, Ariel, Israel.
[Aviva, Binet] Bar Ilan Univ, Sch Educ, IL-52100 Ramat Gan, Israel.
[Zachor, Ditza A.] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
RP Esther-Ben Itzchak (reprint author), Ariel Univ, Ariel, Israel.
EM benitze@ariel.ac.il
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NR 36
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1122
EP 1128
DI 10.1016/j.rasd.2013.05.003
PG 7
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400014
ER
PT J
AU Benson, PR
AF Benson, Paul R.
TI Family influences on social and play outcomes among children with ASD
during middle childhood
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism; Social functioning; Peer play; Family; Mothers
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING CHILDREN; ASSESSING
EXPRESSED EMOTION; DYADIC ADJUSTMENT SCALE; PEER RELATIONSHIPS; MARITAL
CONFLICT; DEVELOPMENTAL-DISABILITIES; INTERPARENTAL CONFLICT; STRESS
PROLIFERATION; DIAGNOSTIC INTERVIEW
AB Using data drawn from a longitudinal study of families of children with autism spectrum disorders (ASD), I examined the concurrent and prospective impact of two family factors, marital quality and maternal expressed emotion (EE) on five indicators of parent-reported child social functioning (number of peers in the child's play network, child participation in unstructured group play, and the extent to which group play was characterized by play interaction, disruption, and disconnection). Controlling for child autism symptom severity, regression analyses indicated martial quality and maternal EE to be significant cross-sectional predictors of number of playmates and group play participation. In addition, marital quality was found to mediate the relationship between symptom severity and both play outcomes. Despite these significant cross-sectional effects, initial analyses revealed no significant longitudinal family effects on play outcomes. Subsequent analyses focusing specifically on the prediction of substantial change in child social functioning over time, however, did find increased play disconnection to be significantly linked to heightened levels of maternal EE, suggesting that familial influences may play a role in hindering improvement in some aspects of social functioning among mid-aged children with ASD. Study implications and limitations are discussed. (C) 2013 Published by Elsevier Ltd.
C1 Dept Sociol, Boston, MA 02125 USA.
RP Benson, PR (reprint author), Dept Sociol, 100 Morrissey Blvd, Boston, MA 02125 USA.
EM paul.benson@umb.edu
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NR 81
TC 2
Z9 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1129
EP 1141
DI 10.1016/j.rasd.2013.06.003
PG 13
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400015
ER
PT J
AU Perry, A
Blacklock, K
Geier, JD
AF Perry, Adrienne
Blacklock, Ksusha
Geier, Jennifer Dunn
TI The relative importance of age and IQ as predictors of outcomes in
Intensive Behavioral Intervention
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Intensive Behavioral Intervention; Predictors of outcome; Cognitive; IQ;
Adaptive behavior; Age effects
ID PERVASIVE DEVELOPMENTAL DISORDER; YOUNG-CHILDREN; AUTISM; PROGRAM
AB Outcomes of Intensive Behavioral Intervention are known to be highly variable. We report on two studies examining the role of age at entry to treatment and initial IQ in relationship to cognitive and adaptive outcomes in the Ontario province-wide program. Study 1 included 207 children aged 2-14 at entry. Age was modestly negatively correlated with several outcome variables; IQ was strongly predictive of most cognitive and adaptive outcomes. Age accounted for additional variance, beyond that accounted for by IQ for cognitive outcomes, especially change in IQ. Children who made very large gains were all under age 6 at entry. Children who were over 8 years of age and/or had very low IQ showed uniformly poor outcomes. Study 2 was a comparison of IQ-matched younger (2-5 years) versus older (6-13 years) children (n = 60 each). The two groups of children, who were on the same initial trajectory, showed different outcomes. Only the younger group showed substantial cognitive gains. Results strongly argue for the importance of early intervention. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Perry, Adrienne; Blacklock, Ksusha] York Univ, Dept Psychol, Toronto, ON M3J 1P3, Canada.
[Geier, Jennifer Dunn] Childrens Hosp Eastern Ontario, Autism Intervent Program Eastern Reg, Ottawa, ON K1J 9B7, Canada.
RP Perry, A (reprint author), York Univ, Dept Psychol, 4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM perry@yorku.ca
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Matson JL, 2013, RES AUTISM SPECT DIS, V7, P809, DOI 10.1016/j.rasd.2013.01.006
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Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2
Smith T, 2000, AM J MENT RETARD, V105, P269, DOI 10.1352/0895-8017(2000)105<0269:RTOIEI>2.0.CO;2
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Sparrow S, 1984, VINELAND ADAPTIVE BE
Sparrow S. S., 2005, VINELAND 2 VINELAND
Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008
NR 27
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1142
EP 1150
DI 10.1016/j.rasd.2013.06.004
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400016
ER
PT J
AU Ruble, LA
Toland, MD
Birdwhistell, JL
McGrew, JH
Usher, EL
AF Ruble, Lisa A.
Toland, Michael D.
Birdwhistell, Jessica L.
McGrew, John H.
Usher, Ellen L.
TI Preliminary Study of the Autism Self-Efficacy Scale for Teachers (ASSET)
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Teacher self-efficacy; Autism spectrum disorders; Special education;
Reliability; Teacher stress; Teacher burnout
ID JOB STRESS; BURNOUT; PROGRAMS; STUDENTS
AB The purpose of the current study was to evaluate a new measure, the Autism Self-Efficacy Scale for Teachers (ASSET) for its dimensionality, internal consistency, and construct validity derived in a sample of special education teachers (N = 44) of students with autism. Results indicate that all items reflect one dominant factor, teachers' responses to items were internally consistent within the sample, and compared to a 100-point scale, a 6-point response scale is adequate. ASSET scores were found to be negatively correlated with scores on two subscale measures of teacher stress (i.e., self-doubt/need for support and disruption of the teaching process) but uncorrelated with teacher burnout scores. The ASSET is a promising tool that requires replication with larger samples. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Ruble, Lisa A.; Toland, Michael D.; Birdwhistell, Jessica L.; Usher, Ellen L.] Univ Kentucky, Lexington, KY 40506 USA.
[McGrew, John H.] Indiana Univ Purdue Univ Indianapolis, Indianapolis, IN USA.
RP Ruble, LA (reprint author), Univ Kentucky, Dept Educ, 237 Dickey Hall, Lexington, KY 40506 USA.
EM lisa.ruble@uky.edu
CR Abidin R., 2004, INDEX OF TEACHING ST
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NR 35
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1151
EP 1159
DI 10.1016/j.rasd.2013.06.006
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400017
ER
PT J
AU Jackson, LS
Little, SG
Akin-Little, A
AF Jackson, Linda Sue
Little, Steven G.
Akin-Little, Angeleque
TI The Spanish adaptation of the Gilliam Autism Rating Scale-2: Translation
and psychometric analysis
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Gilliam Autism Rating Scale; Autism; Spanish; Assessment
ID AUTISM; DIAGNOSIS; CHILDREN
AB Autism is an increasingly prevalent developmental neurological condition that manifests in pervasive impairments in social interaction, communication, and stereotypic behavior and interests. Early identification leads to positive long-term outcomes. At present, all standardized rating instruments are written in English; therefore, the purpose of the present study was to adapt the Gilliam Autism Rating Scale-2 from English into Spanish using the state-of-the-art procedures described in the literature. The English instrument was translated into Spanish, back-translated into English, and then revised using an iterative process. The adapted instrument's psychometric qualities were substantiated. An alpha coefficient of .96 verified the adapted instrument's internal consistency. Results from test-retest comparisons verified the instrument's time stability. The instrument's discriminative validity was confirmed using analysis of variance; the autism group had significantly higher scores than did the other diagnostic groups. Factor analysis verified the construct validity as the items loaded into three clusters that corresponded to the defining characteristics of autism: social interaction, language, and stereotyped behaviors. This culturally and linguistically appropriate assessment tool could be an important instrument for autistic children with Spanish-speaking parents who would otherwise be disenfranchised in regards to early intervention services. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Jackson, Linda Sue] South Texas Coll, Mcallen, TX USA.
[Little, Steven G.] Walden Univ, Minneapolis, MN USA.
[Akin-Little, Angeleque] Little Behav Consultants PLLC, Louisville, KY USA.
RP Little, SG (reprint author), 791 Cty Route 41, Malone, NY 12953 USA.
EM stevenlittlephd@yahoo.com
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NR 27
TC 1
Z9 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1160
EP 1167
DI 10.1016/j.rasd.2013.06.005
PG 8
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400018
ER
PT J
AU Stock, R
Mirenda, P
Smith, IM
AF Stock, Richard
Mirenda, Pat
Smith, Isabel M.
TI Comparison of community-based verbal behavior and pivotal response
treatment programs for young children with autism spectrum disorder
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Early intensive behavioral intervention;
Verbal behavior; Pivotal response treatment
ID PERVASIVE DEVELOPMENTAL DISORDER; EARLY INTERVENTION;
MENTAL-RETARDATION; PRESCHOOLERS; PREDICTORS; IMPLEMENTATION;
METAANALYSIS; OUTCOMES; MODEL; AGE
AB This research compared the outcomes of a community-based group program based on the verbal behavior approach to early intervention (Sautter & LeBlanc, 2006; Sundberg & Michael, 2001) to the outcomes of a program based on Pivotal Response Treatment (Bryson et al., 2007; Koegel & Koegel, 2006). Fourteen preschool children with autism spectrum disorder in each program were matched by baseline chronological age and cognitive score. Assessments were conducted at the initiation of treatment and 12 months later to measure cognitive, receptive and expressive language, and adaptive behavior skills, as well as problem behavior and parenting stress. Results for both groups showed statistically significant changes in cognitive scores, receptive and expressive language age equivalents, and problem behavior scores. Significant results were not found for either adaptive behavior or parenting stress scores. Changes in cognitive and adaptive behavior scores were similar to those reported in published studies of applied behavior analytic programs of similar intensity. Study limitations and recommendations for future research are provided. Although additional research is needed to examine the long-term effectiveness of the programs examined in this study, it appears that both hold promise as effective early intervention approaches that are also relatively cost-effective. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Stock, Richard; Mirenda, Pat] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
[Smith, Isabel M.] Dalhousie Univ, Halifax, NS B3H 3J5, Canada.
RP Stock, R (reprint author), Capilano Univ, Social Sci Div, 2055 Purcell Way, N Vancouver, BC V7J 3H5, Canada.
EM rstock@capilanou.ca
CR Abidin RR, 1995, PARENTING STRESS IND
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NR 67
TC 6
Z9 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD SEP
PY 2013
VL 7
IS 9
BP 1168
EP 1181
DI 10.1016/j.rasd.2013.06.002
PG 14
WC Education, Special; Psychology, Developmental; Psychiatry;
Rehabilitation
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 204IG
UT WOS:000323358400019
ER
PT J
AU Ho, NSP
Lee, TMC
AF Ho, Nerissa S. P.
Lee, Tatia M. C.
TI Alexithymia: The story of a survivor of childhood traumatic brain injury
SO BRAIN INJURY
LA English
DT Article
DE Alexithymia; occipital lobe; social cognition; TBI; traumatic brain
injuries; visual cortex
ID HIGH-FUNCTIONING AUTISM; MENTAL-IMAGERY; ASPERGER-SYNDROME; EMPATHY;
ATTENTION; AMYGDALA; EMOTION; SCALE; RECOGNITION; RELIABILITY
AB Introduction: Affective abnormalities resulting from traumatic brain injuries can pose major threats to the long-term outcomes of neurorehabilitation, especially when they have gone unattended in the process of rehabilitation. This study reports a case of a 46-year-old woman who survived a severe traumatic brain injury to the right occipital cortex (BA18/19) at the age of 10. While her cognitive recovery was remarkable, she has been living with a significant affective disturbance: difficulty with feeling others' feelings.
Method: Neuropsychological tests and self-reported questionnaires capturing the patient's neuropsychological profile, social cognitive abilities, emotional responses, affective awareness and visual imager were administered to the patient.
Results: While cognitive functioning beside attention has recovered well, findings clearly indicate that she is indeed suffering from a high level of alexithymia.
Conclusion: It is speculated that the alexithymia observed may relate to the damage to the visual cortex, which is an important neural substrate for visual imagery and/or damage to the bottom-up stimulus-driven attention system in the right hemisphere. This case exemplified a possible organic basis of social affective disturbance, which may be overlooked in the process of neurorehabilitation.
C1 [Ho, Nerissa S. P.; Lee, Tatia M. C.] Univ Hong Kong, Neuropsychol Lab, Hong Kong, Hong Kong, Peoples R China.
[Ho, Nerissa S. P.; Lee, Tatia M. C.] Univ Hong Kong, Lab Cognit Affect Neurosci, Hong Kong, Hong Kong, Peoples R China.
[Lee, Tatia M. C.] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China.
[Lee, Tatia M. C.] Univ Hong Kong, Inst Clin Neuropsychol, Hong Kong, Hong Kong, Peoples R China.
RP Lee, TMC (reprint author), Univ Hong Kong, Neuropsychol Lab, C656,Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.
EM tmclee@hku.hk
FU University of Hong Kong; Research Grant Council of Hong Kong
[HKU747612H]
FX This project was supported by the Endowed Professorship of The
University of Hong Kong and the General Research Fund of Research Grant
Council of Hong Kong (HKU747612H).
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NR 46
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0269-9052
J9 BRAIN INJURY
JI Brain Inj.
PD SEP
PY 2013
VL 27
IS 10
BP 1199
EP 1205
DI 10.3109/02699052.2013.804198
PG 7
WC Neurosciences; Rehabilitation
SC Neurosciences & Neurology; Rehabilitation
GA 204KW
UT WOS:000323365200013
PM 23895444
ER
PT J
AU Simpson, W
Brown, C
Nisbet, N
Metcalfe, R
Claisse, Z
Watson, L
AF Simpson, Wendy
Brown, Carolyn
Nisbet, Nara
Metcalfe, Ruth
Claisse, Zoe
Watson, Lorna
TI Innovations in Practice: A new model of autism spectrum disorder
assessment and diagnosis by multiagency community-based teams in primary
schools
SO CHILD AND ADOLESCENT MENTAL HEALTH
LA English
DT Article
DE Autistic disorder; diagnosis; school children; evaluation
AB Background: National guidelines stress the importance of early diagnosis of autism spectrum disorder (ASD). This pilot investigated the feasibility and acceptability of assessing children in their community. Method: The pilot study was carried out from August 2007 to January 2009, and the roll-out of the programme started in 2010 and is currently underway. Workers undertook assessments and made a group decision about diagnosis; participant observation of these team meetings explored the decision-making process. Semistructured interviews and focus groups explored the views of parents and professionals. Results: Seventeen children took part in the study: six were diagnosed with ASD; three as not ASD, and eight were referred for further assessment. The model was found acceptable to parents and workers. Conclusions: With detailed consideration of administration, information, communication and training requirements, this approach has the potential to increase early diagnosis of ASD and reduce demand for specialist assessment.
C1 [Simpson, Wendy] Stratheden Hosp, Playfield Inst, Cupar KY15 5RR, Fife, Scotland.
RP Simpson, W (reprint author), Stratheden Hosp, Playfield Inst, Cupar KY15 5RR, Fife, Scotland.
EM w.simpson@nhs.net
CR Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002
Howlin P, 1999, DEV MED CHILD NEUROL, V41, P834, DOI 10.1017/S0012162299001656
Le Couteur A., 2003, NATL INITIATIVE AUTI
LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145
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Moore V., 1998, CHILD PSYCHOL PSYCHI, V3, P116, DOI 10.1017/S1360641798001622
Public Health Institute of Scotland (PHIS), 2001, AUT SPECTR DIS NEEDS
Scottish Government, 2012, GETT IT RIGHT EV CHI
Scottish Intercollegiate Guidelines Network [SIGN], 2007, ASS DIAGN CLIN INT C
NR 9
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-357X
J9 CHILD ADOL MENT H-UK
JI Child Adolesc. Ment. Health
PD SEP
PY 2013
VL 18
IS 3
SI SI
BP 187
EP 190
DI 10.1111/j.1475-3588.2012.00679.x
PG 4
WC Psychology, Clinical; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 204QP
UT WOS:000323383400010
ER
PT J
AU Berney, T
AF Berney, Tom
TI Working with Parents of a Newly Diagnosed Child with an Autism Spectrum
Disorder: a Guide for Professionals
SO CHILD AND ADOLESCENT MENTAL HEALTH
LA English
DT Book Review
C1 [Berney, Tom] Northumberland Tyne & Wear NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England.
RP Berney, T (reprint author), Northumberland Tyne & Wear NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England.
CR Keen D, 2012, WORKING PARENTS NEWL
NR 1
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-357X
J9 CHILD ADOL MENT H-UK
JI Child Adolesc. Ment. Health
PD SEP
PY 2013
VL 18
IS 3
SI SI
BP 191
EP 191
DI 10.1111/camh.12037_2
PG 1
WC Psychology, Clinical; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA 204QP
UT WOS:000323383400012
ER
PT J
AU Campbell, M
Reynolds, L
Cunningham, J
Minnis, H
Gillberg, C
AF Campbell, M.
Reynolds, L.
Cunningham, J.
Minnis, H.
Gillberg, C.
TI Autism in Glasgow: cumulative incidence and the effects of referral age,
deprivation and geographical location
SO CHILD CARE HEALTH AND DEVELOPMENT
LA English
DT Article
DE autism; cumulative incidence; deprivation; geographical area;
prevalence; Scotland
ID SPECTRUM DISORDERS; EARLY INTERVENTION; CHILDREN; POPULATION;
PREVALENCE; EPIDEMIOLOGY; RISK
AB Background Referrals to the Greater Glasgow Community Autism Team (CAT) made before the child's sixth birthday were analysed to obtain an estimation of the proportion of children in Greater Glasgow with childhood autism and investigate whether there were any variations in diagnosis rates, or in age at referral and diagnosis, depending on deprivation or geographical location. Methods An analysis was made of the database recording referrals to Greater Glasgow CAT, between 2004 and 2007 inclusive, of children referred by age 6 years, comprising 584 cases. Cumulative incidence was calculated for childhood autism. Ages at referral and diagnosis were also analysed. Results For this subset of children, there were 246 diagnosed cases of childhood autism, a cumulative incidence from 2004 until 2007 of 11.1 per year per 10000 children aged 0-6 years. Of children with an eventual diagnosis of autism by age 6, 72% were referred by the age of 4 years. Deprivation was found to have an association with referral and diagnostic rates, with higher rates seen in the most deprived. There was geographical variation in the cumulative incidence of autism. Conclusion Given that the populations were not known to differ in any manner that would lead to a true variation, the geographical variation in the cumulative incidence of autism in children up to 6 years in Greater Glasgow observed in this study is likely to represent differences in the care pathway between areas. Such differences may also explain the observed association with deprivation. Reasons for the variation are being explored.
C1 [Campbell, M.] Univ Glasgow, Paediat Epidemiol & Community Hlth PEACH Unit, Glasgow G3 8SJ, Lanark, Scotland.
[Reynolds, L.] NHS Greater Glasgow & Clyde, Child Publ Hlth Team, Glasgow, Lanark, Scotland.
[Cunningham, J.] NHS Greater Glasgow & Clyde, Southbank Child Dev Ctr, Glasgow, Lanark, Scotland.
[Minnis, H.; Gillberg, C.] Univ Glasgow, Coll Med Vet & Life Sci, Ctr Populat & Hlth Sci, Glasgow G3 8SJ, Lanark, Scotland.
RP Campbell, M (reprint author), Univ Glasgow, Paediat Epidemiol & Community Hlth PEACH Unit, Yorkhill Hosp, 8th Floor Tower Block,Dalnair St, Glasgow G3 8SJ, Lanark, Scotland.
EM m.campbell@clinmed.gla.ac.uk
FU NHS Greater Glasgow Clyde
FX This research was made possible by the funding of the first author as
Translational Researcher in Evidence Based Child Public Health by NHS
Greater Glasgow & Clyde. We thank Sharon Keatings, the administrator who
maintains the Greater Glasgow Community Autism Team database.
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Scottish Government, 2010, DEPR SCOTT IND MULT
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NR 20
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1862
J9 CHILD CARE HLTH DEV
JI Child Care Health Dev.
PD SEP
PY 2013
VL 39
IS 5
BP 688
EP 694
DI 10.1111/j.1365-2214.2011.01340.x
PG 7
WC Psychology, Developmental; Pediatrics
SC Psychology; Pediatrics
GA 201OH
UT WOS:000323150400008
PM 22040464
ER
PT J
AU Pellicano, E
AF Pellicano, Elizabeth
TI Sensory Symptoms in Autism: A Blooming, Buzzing Confusion?
SO CHILD DEVELOPMENT PERSPECTIVES
LA English
DT Article
DE autism; sensory symptoms; perception; Bayesian
ID SPECTRUM DISORDERS; PERCEPTION; CHILDREN; ABNORMALITIES; EXPERIENCES;
COHERENCE; KNOWLEDGE; ILLUSION
AB Autism is well known for the way it affects how a person interacts and communicates with others. But autism can affect behavior in other important and debilitating ways, such as in an intense desire for sameness and in sensory systems that work too well or not well enough. Researchers have largely overlooked the latter sensory symptoms, but their prominence in forthcoming diagnostic criteria calls for systematic investigation. In this article, I review existing theoretical accounts of autism and provide an overview of a new theoretical account that proposes using Bayesian methods to identify the nature of the (altered) computations involved in autistic sensation and perception. Specifically, the account suggests that sensory symptoms may be due to fewer prior constraints or attenuated priors. The possibility that autistic people perceive the world as it really is rather than as imbued by prior experiences may explain the range and idiosyncrasy of their sensory sensitivities and their difficulties dealing with new experiences.
C1 [Pellicano, Elizabeth] Univ London, Ctr Res Autism & Educ, Dept Psychol & Human Dev, Inst Educ, London WC1E 7HU, England.
[Pellicano, Elizabeth] Univ Western Australia, Sch Psychol, Nedlands, WA 6009, Australia.
RP Pellicano, E (reprint author), Inst Educ, Ctr Res Autism & Educ, Dept Psychol & Human Dev, 25 Woburn Sq, London WC1H 0AA, England.
EM l.pellicano@ioe.ac.uk
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Williams D, 1994, SOMEBODY SOMEWHERE
NR 49
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1750-8592
J9 CHILD DEV PERSPECT
JI Child Develop. Perspect.
PD SEP
PY 2013
VL 7
IS 3
BP 143
EP 148
DI 10.1111/cdep.12031
PG 6
WC Psychology, Developmental
SC Psychology
GA 198JN
UT WOS:000322919000003
ER
PT J
AU Rosenberg, RE
Law, JK
Anderson, C
Samango-Sprouse, C
Law, PA
AF Rosenberg, Rebecca E.
Law, J. Kiely
Anderson, Connie
Samango-Sprouse, Carole
Law, Paul A.
TI Survey of Vaccine Beliefs and Practices Among Families Affected by
Autism Spectrum Disorders
SO CLINICAL PEDIATRICS
LA English
DT Article
ID UNITED-STATES; CHILDREN
C1 [Rosenberg, Rebecca E.; Law, J. Kiely; Anderson, Connie; Law, Paul A.] Kennedy Krieger Inst, Baltimore, MD 21211 USA.
[Law, J. Kiely; Law, Paul A.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Samango-Sprouse, Carole] George Washington Univ, Washington, DC USA.
[Samango-Sprouse, Carole] Neurodev Diagnost Ctr Young Children, Davidsonville, MD USA.
RP Law, PA (reprint author), Kennedy Krieger Inst, Dept Med Informat, 1st Floor,Painter Bldg,3825 Greenspring Ave, Baltimore, MD 21211 USA.
EM lawp@kennedkrieger.org
FU Autism Speaks; SafeMinds
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This study
was supported by Autism Speaks and SafeMinds. The opinions expressed
herein are those of the authors and do not necessarily reflect the views
of Autism Speaks or SafeMinds. The funders had no input regarding study
design or conduct, data analysis or interpretation, manuscript
preparation, or the decision to submit the results for publication.
CR Bocchini JA, 2009, PEDIATRICS, V123, P189, DOI 10.1542/peds.2008-3306
Wooten K. G., 2010, Morbidity and Mortality Weekly Report, V59, P1171
Daniels AM, 2012, J AUTISM DEV DISORD, V42, P257, DOI 10.1007/s10803-011-1236-7
Freed GL, 2010, PEDIATRICS, V125, P654, DOI 10.1542/peds.2009-1962
Gerber JS, 2009, CLIN INFECT DIS, V48, P456, DOI 10.1086/596476
Hilton S, 2007, ARCH DIS CHILD, V92, P322, DOI 10.1136/adc.2006.10968
Institute of Medicine, 2004, IMM SAF REV VACC AUT
Kuwaik G, 2008, PEDIATRICS, V122, P684, DOI 10.1542/peds.2008-1624
Lee H, 2010, AM J MED GENET B, V153B, P1119, DOI 10.1002/ajmg.b.31103
Woo EJ, 2004, AM J PUBLIC HEALTH, V94, P990, DOI 10.2105/AJPH.94.6.990
NR 10
TC 4
Z9 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0009-9228
J9 CLIN PEDIATR
JI Clin. Pediatr.
PD SEP
PY 2013
VL 52
IS 9
BP 871
EP 874
DI 10.1177/0009922812438435
PG 4
WC Pediatrics
SC Pediatrics
GA 205ZN
UT WOS:000323484400010
PM 22387922
ER
PT J
AU van Wijngaarden, E
Davidson, PW
Smith, TH
Evans, K
Yost, K
Love, T
Thurston, SW
Watson, GE
Zareba, G
Burns, CM
Shamlaye, CF
Myers, GJ
AF van Wijngaarden, Edwin
Davidson, Philip W.
Smith, Tristram H.
Evans, Katie
Yost, Kelley
Love, Tanzy
Thurston, Sally W.
Watson, Gene E.
Zareba, Grazyna
Burns, Christine M.
Shamlaye, Conrad F.
Myers, Gary J.
TI Autism Spectrum Disorder Phenotypes and Prenatal Exposure to
Methylmercury
SO EPIDEMIOLOGY
LA English
DT Article
AB Background:
There continues to be public concern that mercury exposure and autism spectrum disorder (ASD) may be associated. The primary source of exposure to organic mercury in humans is to methylmercury from fish consumption. We evaluated the association between prenatal methylmercury exposure and ASD phenotype in children and adolescents in the Republic of Seychelles, where fish consumption is high.
Methods:
We administered the Social Communication Questionnaire to parents of a cohort of 1784 children, adolescents, and young adults. The Social Responsiveness Scale was administered to teachers of 537 cohort subjects at about 10 years of age. Prenatal exposure to methylmercury was measured in maternal hair samples collected at or near the time of birth. Multivariable regression models evaluated the relationship between prenatal methylmercury exposure and ASD phenotypic scores, adjusting for relevant covariates.
Results:
The mean prenatal methylmercury exposure for subjects in the analysis was 8.4 ppm (standard deviation [SD] = 5.7). The mean Social Communication Questionnaire score was 8.0 (SD = 4.4). The mean prenatal methylmercury exposure for subjects with Social Responsiveness Scale scores was 6.7 ppm (SD = 4.4) and the mean Social Responsiveness Scale score was 57.6 (SD = 26.8). No consistent association between prenatal methylmercury exposure and ASD screening instrument was found, using linear and nonlinear regression analyses.
Conclusions:
Prenatal exposure to methylmercury was not associated with ASD phenotypic behaviors in our cohort of high fish consumers. Our findings contribute to the growing literature suggesting that exposure to methylmercury does not play an important role in the development of ASD phenotypic behavior.
C1 [van Wijngaarden, Edwin] Univ Rochester, Sch Med & Dent, Dept Publ Hlth Sci, Rochester, NY 14642 USA.
[van Wijngaarden, Edwin; Watson, Gene E.; Zareba, Grazyna; Myers, Gary J.] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA.
[van Wijngaarden, Edwin; Watson, Gene E.] Univ Rochester, Sch Med & Dent, Eastman Dept Dent, Rochester, NY 14642 USA.
[Davidson, Philip W.; Smith, Tristram H.; Yost, Kelley; Burns, Christine M.; Myers, Gary J.] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA.
[Davidson, Philip W.] Univ Rochester, Sch Med & Dent, Dept Psychiat, Rochester, NY 14642 USA.
[Evans, Katie; Love, Tanzy; Thurston, Sally W.] Univ Rochester, Sch Med & Dent, Dept Biostat, Rochester, NY 14642 USA.
[Shamlaye, Conrad F.] Seychelles Minist Hlth, Victoria, Mahe, Seychelles.
[Myers, Gary J.] Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USA.
RP van Wijngaarden, E (reprint author), Univ Rochester, Sch Med & Dent, Dept Publ Hlth Sci, 265 Crittenden Blvd,CU 420644, Rochester, NY 14642 USA.
EM edwin_van_wijngaarden@urmc.rochester.edu
FU US National Institute of Environmental Health Sciences, National
Institutes of Health [R21-ES-15487, RO1-ES010219, R01-ES-015578,
R01-ES-08442, P30-ES01247, T32-ES007271]; Government of the Republic of
Seychelles
FX This research was supported by grants R21-ES-15487, RO1-ES010219,
R01-ES-015578, R01-ES-08442, P30-ES01247, and T32-ES007271 from the US
National Institute of Environmental Health Sciences, National Institutes
of Health, and by the Government of the Republic of Seychelles.
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NR 41
TC 5
Z9 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD SEP
PY 2013
VL 24
IS 5
BP 651
EP 659
DI 10.1097/EDE.0b013e31829d2651
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 200YL
UT WOS:000323107600005
PM 23873071
ER
PT J
AU Suren, P
Stoltenberg, C
Bresnahan, M
Hirtz, D
Lie, KK
Lipkin, WI
Magnus, P
Reichborn-Kjennerud, T
Schjolberg, S
Susser, E
Oyen, AS
Li, L
Hornig, M
AF Suren, Pal
Stoltenberg, Camilla
Bresnahan, Michaeline
Hirtz, Deborah
Lie, Kari Kveim
Lipkin, W. Ian
Magnus, Per
Reichborn-Kjennerud, Ted
Schjolberg, Synnve
Susser, Ezra
Oyen, Anne-Siri
Li, Leah
Hornig, Mady
TI Early Growth Patterns in Children with Autism
SO EPIDEMIOLOGY
LA English
DT Article
AB Background: Case-control studies have found increased head growth during the first year of life in children with autism spectrum disorder. Length and weight have not been as extensively studied, and there are few studies of population-based samples.
Methods: The study was conducted in a sample of 106,082 children from the population-based Norwegian Mother and Child Cohort. The children were born in 1999-2009; by the end of follow-up on 31 December 2012, the age range was 3.6 through 13.1 years (mean 7.4 years). Measures were obtained prospectively until age 12 months for head circumference and 36 months for length and weight. We compared growth trajectories in autism spectrum disorder cases and noncases using Reed first-order models.
Results: Subjects included 376 children (310 boys and 66 girls) with specialist-confirmed autism spectrum disorder. In boys with autism spectrum disorder, mean head growth was similar to that of other boys, but variability was greater, and 8.7% had macrocephaly (head circumference >97th cohort percentile) by 12 months of age. Autism spectrum disorder boys also had slightly increased body growth, with mean length 1.1cm above and mean weight 300g above the cohort mean for boys at age 12 months. Throughout the first year, the head circumference of girls with autism spectrum disorder was reduced by 0.3cm at birth and 0.5cm at 12 months. Their mean length was similar to that of other girls, but their mean weight was 150-350g below at all ages from birth to 3 years. The reductions in mean head circumference and weight in girls with autism spectrum disorder appear to be driven by those with intellectual disability, genetic disorders, and epilepsy.
Discussion: Growth trajectories in children with autism spectrum disorder diverge from those of other children and the differences are sex specific. Previous findings of increased mean head growth were not replicated.
C1 [Suren, Pal; Li, Leah] UCL Inst Child Hlth, Ctr Paediat Epidemiol & Biostat, London, England.
[Suren, Pal; Stoltenberg, Camilla; Lie, Kari Kveim; Magnus, Per; Reichborn-Kjennerud, Ted; Schjolberg, Synnve; Oyen, Anne-Siri] Norwegian Inst Publ Hlth, N-0403 Oslo, Norway.
[Bresnahan, Michaeline; Lipkin, W. Ian; Susser, Ezra; Hornig, Mady] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA.
[Bresnahan, Michaeline; Susser, Ezra] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[Hirtz, Deborah] NINDS, Bethesda, MD 20892 USA.
[Reichborn-Kjennerud, Ted] Univ Oslo, Inst Psychiat, Oslo, Norway.
[Oyen, Anne-Siri] Lovisenberg Hosp, Nic Waals Inst, Oslo, Norway.
RP Suren, P (reprint author), Norwegian Inst Publ Hlth, POB 4404 Nydalen, N-0403 Oslo, Norway.
EM pal.suren@fhi.no
FU Norwegian Ministry of Health and Care Services; Norwegian Ministry of
Education and Research; Research Council of Norway/FUGE [151918];
National Institute of Neurological Disorders and Stroke (NIH/NINDS),
Bethesda [NS47537]; National Institute of Environmental Health Sciences
(NIH/NIEHS), Research Triangle Park, NC [NO-ES-75558]; NINDS [NS47537
[Lipkin]]; Research Council of Norway [185476, 190694]; UK Medical
Research Council (MRC) Career Development Award in Biostatistics; MRC
FX The Norwegian Mother and Child Cohort is supported by the Norwegian
Ministry of Health and Care Services, the Norwegian Ministry of
Education and Research, the Research Council of Norway/FUGE (grant
151918), the National Institute of Neurological Disorders and Stroke
(NIH/NINDS), Bethesda (grant NS47537), and the National Institute of
Environmental Health Sciences (NIH/NIEHS), Research Triangle Park, NC
(contract NO-ES-75558). The Autism Birth Cohort study is funded by the
NINDS (grant NS47537 [Lipkin]). P.S. is funded by the Research Council
of Norway, grant numbers 185476 and 190694. L.L. is funded by a UK
Medical Research Council (MRC) Career Development Award in
Biostatistics. The Centre for Paediatric Epidemiology and Biostatistics
is supported by the MRC in its capacity as the MRC Centre of
Epidemiology for Child Health.
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NR 36
TC 9
Z9 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD SEP
PY 2013
VL 24
IS 5
BP 660
EP 670
DI 10.1097/EDE.0b013e31829e1d45
PG 11
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 200YL
UT WOS:000323107600006
PM 23867813
ER
PT J
AU Bellani, M
Calderoni, S
Muratori, F
Brambilla, P
AF Bellani, M.
Calderoni, S.
Muratori, F.
Brambilla, P.
TI Brain anatomy of autism spectrum disorders I. Focus on corpus callosum
SO EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
LA English
DT Article
DE autism spectrum disorders (ASD); corpus callosum; magnetic resonance
imaging (MRI); volumes
ID VOXEL-BASED MORPHOMETRY; HIGH-FUNCTIONING AUTISM; STRUCTURAL MRI;
CONNECTIVITY; CHILDREN; ABNORMALITIES; TRACTOGRAPHY; DEFICITS; VOLUME
AB This brief review aims to examine the structural magnetic resonance imaging (sMRI) studies on corpus callosum in autism spectrum disorders (ASD) and discuss the clinical and demographic factors involved in the interpretation of results.
C1 [Bellani, M.] Univ Verona, Sect Psychiat, Dept Publ Hlth & Community Med, I-37134 Verona, Italy.
[Bellani, M.] Univ Verona, Sect Clin Psychol, ICBN, I-37134 Verona, Italy.
[Calderoni, S.; Muratori, F.] IRCCS Stella Maris Fdn, Pisa, Italy.
[Muratori, F.] Univ Pisa, Dept Child Neurol & Psychiat, Pisa, Italy.
[Brambilla, P.] Univ Udine, Dept Expt Clin Med, ICBN, I-33100 Udine, Italy.
[Brambilla, P.] Univ Texas Med Sch, Dept Psychiat & Behav Sci, Houston, TX USA.
RP Bellani, M (reprint author), Univ Verona, Sect Psychiat, Dept Publ Hlth & Community Med, Piazzale LA Scuro 10, I-37134 Verona, Italy.
EM marcella.bellani@univr.it
FU Italian Ministry of Health; Tuscany Region [GR-2010-2317873]; European
Union (The MICHELANGELO Project)
FX S. C. was partly supported by the Italian Ministry of Health and by
Tuscany Region with the grant 'GR-2010-2317873'. F. M. and S. C. were
partly supported by the European Union (The MICHELANGELO Project). The
other authors received no specific grant from any funding agency,
commercial or not-for-profit sectors.
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NR 27
TC 4
Z9 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2045-7960
J9 EPIDEMIOL PSYCH SCI
JI Epidemiol. Psychiatr. Sci.
PD SEP
PY 2013
VL 22
IS 3
BP 217
EP 221
DI 10.1017/S2045796013000139
PG 5
WC Psychiatry
SC Psychiatry
GA 201SP
UT WOS:000323163600006
PM 23531487
ER
PT J
AU Plavnick, JB
Sam, AM
Hume, K
Odom, SL
AF Plavnick, Joshua B.
Sam, Ann M.
Hume, Kara
Odom, Samuel L.
TI Effects of Video-Based Group Instruction for Adolescents With Autism
Spectrum Disorder
SO EXCEPTIONAL CHILDREN
LA English
DT Article
ID SOCIAL-SKILLS INTERVENTIONS; TEACHING-CHILDREN; BEHAVIOR; REINFORCEMENT;
METAANALYSIS; INDIVIDUALS; QUESTIONS
AB Impairment in social interaction is a defining characteristic of individuals diagnosed with autism spectrum disorder (ASD). This can be especially challenging for adolescents as demands of social interaction increase in difficulty. Despite the need for effective social skills instruction, there are few empirically validated procedures for teaching social skills to adolescents with ASD. The present investigation evaluated the effects of a social skills training package centered around video-based group instruction (VGI) on the acquisition of complex social skills by 4 adolescents with ASD. A multiple probe across behaviors design demonstrated the effectiveness of the 3-month training package for teaching new social skills. The results suggest VGI can be an effective and efficient approach for teaching complex social behavior to adolescents with ASD.
C1 [Plavnick, Joshua B.] Michigan State Univ, Dept Counseling Educ Psychol & Special Educ, E Lansing, MI 48824 USA.
[Sam, Ann M.] 3C Inst Social Dev, Cary, NC USA.
[Hume, Kara; Odom, Samuel L.] Univ N Carolina, Frank Porter Graham Child Dev Inst, Chapel Hill, NC 27515 USA.
RP Plavnick, JB (reprint author), Michigan State Univ, Dept Counseling Educ Psychol & Special Educ, 620 Farm Lane 341, E Lansing, MI 48824 USA.
EM plavnick@msu.edu
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NR 35
TC 3
Z9 3
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 0014-4029
J9 EXCEPT CHILDREN
JI Except. Child.
PD FAL
PY 2013
VL 80
IS 1
BP 67
EP 83
PG 17
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 202CJ
UT WOS:000323190800005
ER
PT J
AU Sgado, P
Genovesi, S
Kalinovsky, A
Zunino, G
Macchi, F
Allegra, M
Murenu, E
Provenzano, G
Tripathi, PP
Casarosa, S
Joyner, AL
Bozzi, Y
AF Sgado, Paola
Genovesi, Sacha
Kalinovsky, Anna
Zunino, Giulia
Macchi, Francesca
Allegra, Manuela
Murenu, Elisa
Provenzano, Giovanni
Tripathi, Prem Prakash
Casarosa, Simona
Joyner, Alexandra L.
Bozzi, Yuri
TI Loss of GABAergic neurons in the hippocampus and cerebral cortex of
Engrailed-2 null mutant mice: Implications for autism spectrum disorders
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Homeobox transcription factor; Inhibition; Interneuron; Parvalbumin;
Neurodevelopmental disorder
ID MESENCEPHALIC DOPAMINERGIC-NEURONS; HOMEOBOX-TRANSCRIPTION-FACTOR;
CEREBELLAR DEVELOPMENT; KNOCKOUT MICE; GLUTAMATE-DECARBOXYLASE; INDUCED
SEIZURES; PURKINJE-CELLS; MOUSE MODELS; GENES; EXPRESSION
AB The homeobox-containing transcription factor Engrailed-2 (En2) is involved in patterning and neuronal differentiation of the midbrain/hindbrain region, where it is prominently expressed. En2 mRNA is also expressed in the adult mouse hippocampus and cerebral cortex, indicating that it might also function in these brain areas. Genome-wide association studies revealed that En2 is a candidate gene for autism spectrum disorders (ASD), and mice devoid of its expression (En2(-/-) mice) display anatomical, behavioral and clinical "autistic-like" features. Since reduced GABAergic inhibition has been proposed as a possible pathogenic mechanism of ASD, we hypothesized that the phenotype of En2(-/-) mice might include defective GABAergic innervation in the forebrain. Here we show that the Engrailed proteins are present in postnatal GABAergic neurons of the mouse hippocampus and cerebral cortex, and adult En2(-/-) mice show reduced expression of GABAergic marker mRNAs in these areas. In addition, reduction in parvalbumin (PV), somatostatin (SOM) and neuropeptide Y (NPY) expressing interneurons is detected in the hippocampus and cerebral cortex of adult En2(-/-) mice. Our results raise the possibility of a link between altered function of En2, anatomical deficits of GABAergic forebrain neurons and the pathogenesis of ASD. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Sgado, Paola; Genovesi, Sacha; Zunino, Giulia; Provenzano, Giovanni; Bozzi, Yuri] Univ Trent, Ctr Integrat Biol CIBIO, Lab Mol Neuropathol, I-38123 Trento, Italy.
[Kalinovsky, Anna; Joyner, Alexandra L.] Sloan Kettering Inst, Dev Biol Program, New York, NY USA.
[Macchi, Francesca; Allegra, Manuela; Tripathi, Prem Prakash; Casarosa, Simona; Bozzi, Yuri] CNR Neurosci Inst, Pisa, Italy.
[Murenu, Elisa; Casarosa, Simona] Univ Trent, Ctr Integrat Biol CIBIO, Dev Neurobiol Lab, I-38123 Trento, Italy.
RP Bozzi, Y (reprint author), Univ Trent, Ctr Integrat Biol CIBIO, Lab Mol Neuropathol, Via Regole 101, I-38123 Trento, Italy.
EM bozzi@science.unitn.it
FU Provincia Autonoma di Trento (Italy) under European Community; Italian
Ministry of University and Research [200894SYW2_002]; University of
Trento (CIBIO); National Institutes of Health, USA [MH085726]
FX P.S. is supported by Provincia Autonoma di Trento (Italy) under the
Marie Curie-People cofunding action of the European Community. This work
was funded by the Italian Ministry of University and Research (PRIN 2008
grant # 200894SYW2_002 to Y.B.), the University of Trento (CIBIO
start-up grant to S.C. and Y.B.), and a grant from the National
Institutes of Health, USA (MH085726 to We thank Andrea Messina, Mark
Dunleavy (CIBIO, University of Trento, Italy), Enrico Tongiorgi
(University of Trieste, Italy), Massimo Pasqualetti (Biology Dept.,
University of Pisa, Italy), Matte Caleo (CNR Neuroscience Institute,
Pisa, Italy) for helpful discussions and reagents, and Patrizia Paoli
(CIBIO, University of Trento, Italy), Barbara Roncolini, Elena Orsucci
(CNR Neuroscience Institute, Pisa, Italy) for administrative support.
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NR 53
TC 11
Z9 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
J9 EXP NEUROL
JI Exp. Neurol.
PD SEP
PY 2013
VL 247
BP 496
EP 505
DI 10.1016/j.expneurol.2013.01.021
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 204VO
UT WOS:000323399600059
PM 23360806
ER
PT J
AU Szalontai, A
Csiszar, K
AF Szalontai, Adam
Csiszar, Katalin
TI Genetic insights into the functional elements of language
SO HUMAN GENETICS
LA English
DT Review
ID AUTISM SPECTRUM DISORDER; DEVELOPMENTAL VERBAL DYSPRAXIA; SPEECH SOUND
DISORDER; FRAGILE-X-SYNDROME; WOLF-HIRSCHHORN SYNDROME; WILLIAMS-BEUREN
SYNDROME; DE-NOVO MUTATIONS; RETT-SYNDROME; INTELLECTUAL DISABILITY;
DYSMORPHIC FEATURES
AB Language disorders cover a wide range of conditions with heterologous and overlapping phenotypes and complex etiologies harboring both genetic and environmental influences. Genetic approaches including the identification of genes linked to speech and language phenotypes and the characterization of normal and aberrant functions of these genes have, in recent years, unraveled complex details of molecular and cognitive mechanisms and provided valuable insight into the biological foundations of language. Consistent with this approach, we have reviewed the functional aspects of allelic variants of genes which are currently known to be either causally associated with disorders of speech and language or impact upon the spectrum of normal language ability. We have also reviewed candidate genes associated with heritable speech and language disorders. In addition, we have evaluated language phenotypes and associated genetic components in developmental syndromes that, together with a spectrum of altered language abilities, manifest various phenotypes and offer details of multifactorial determinants of language function. Data from this review have revealed a predominance of regulatory networks involved in the control of differentiation and functioning of neurons, neuronal tracks and connections among brain structures associated with both cognitive and language faculties. Our findings, furthermore, have highlighted several multifactorial determinants in overlapping speech and language phenotypes. Collectively this analysis has revealed an interconnected developmental network and a close association of the language faculty with cognitive functions, a finding that has the potential to provide insight into linguistic hypotheses defining in particular, the contribution of genetic elements to and the modular nature of the language faculty.
C1 [Szalontai, Adam] Eotvos Lorand Univ, Theoret Linguist Program, Budapest, Hungary.
[Csiszar, Katalin] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA.
RP Csiszar, K (reprint author), Univ Hawaii, John A Burns Sch Med, 1960 East West Rd,Biomed T415, Honolulu, HI 96822 USA.
EM kcsiszar@aol.com
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NR 204
TC 4
Z9 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
EI 1432-1203
J9 HUM GENET
JI Hum. Genet.
PD SEP
PY 2013
VL 132
IS 9
BP 959
EP 986
DI 10.1007/s00439-013-1317-0
PG 28
WC Genetics & Heredity
SC Genetics & Heredity
GA 202UW
UT WOS:000323246200001
PM 23749164
ER
PT J
AU Nickel, LR
Thatcher, AR
Keller, F
Wozniak, RH
Iverson, JM
AF Nickel, Lindsay R.
Thatcher, Alyssa R.
Keller, Flavio
Wozniak, Robert H.
Iverson, Jana M.
TI Posture Development in Infants at Heightened versus Low Risk for Autism
Spectrum Disorders
SO INFANCY
LA English
DT Article
ID OBJECT EXPLORATION; MOTOR DEVELOPMENT; RECURRENCE RISK; SIBLINGS;
CHILDREN; COMMUNICATION; LANGUAGE
AB Evidence suggests that children and adults diagnosed with autism spectrum disorders (ASD) exhibit difficulties with postural control. Retrospective video studies of infants later diagnosed with ASD indicate that infants who eventually receive an ASD diagnosis exhibit delays in postural development. This study investigates early posture development prospectively and longitudinally in 22 infants at heightened biological risk for ASD (HR) and 18 infants with no such risk (Low Risk; LR). Four HR infants received an autism diagnosis (AD infants) at 36months. Infants were videotaped at home at 6, 9, 12, and 14months during everyday activities and play. All infant postures were coded and classified as to whether or not they were infant-initiated. Relative to LR infants, HR infants were slower to develop skill in sitting and standing postures. AD infants exhibited substantial delays in the emergence of more advanced postures and initiated fewer posture changes. Because posture advances create opportunities for infants to interact with objects and people in new and progressively more sophisticated ways, postural delays may have cascading effects on opportunities for infant exploration and learning. These effects may be greater for infants with ASD, for whom posture delays are more significant.
C1 [Nickel, Lindsay R.; Thatcher, Alyssa R.; Iverson, Jana M.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
[Wozniak, Robert H.] Bryn Mawr Coll, Dept Psychol, Bryn Mawr, PA 19010 USA.
RP Iverson, JM (reprint author), Univ Pittsburgh, Dept Psychol, 210 S Bouquet St, Pittsburgh, PA 15260 USA.
EM jiverson@pitt.edu
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NR 42
TC 8
Z9 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1525-0008
J9 INFANCY
JI Infancy
PD SEP
PY 2013
VL 18
IS 5
BP 639
EP 661
DI 10.1111/infa.12025
PG 23
WC Psychology, Developmental
SC Psychology
GA 201UF
UT WOS:000323167800001
ER
PT J
AU Ibanez, LV
Grantz, CJ
Messinger, DS
AF Ibanez, Lisa V.
Grantz, Caroline J.
Messinger, Daniel S.
TI The Development of Referential Communication and Autism Symptomatology
in High-Risk Infants
SO INFANCY
LA English
DT Article
ID JOINT ATTENTION; NONVERBAL-COMMUNICATION; SPECTRUM DISORDERS; YOUNGER
SIBLINGS; SOCIAL COGNITION; MOTHER-INFANT; CHILDREN; ENGAGEMENT;
BEHAVIORS
AB Non-verbal referential communication is impaired in children with autism spectrum disorders (ASD). However, the development of difficulties with referential communication in the younger siblings of children with ASD (High-Risk Siblings)and the degree to which early referential communication predicts later autism symptomatologyis not clear. We modeled the early developmental trajectories of three types of referential communication: responding to joint attention (RJA), initiating joint attention (IJA), and initiating behavioral requests (IBR) across 8, 10, 12, 15, and 18months of age in High-Risk Siblings (n=40) and the infant siblings of children without ASD (Low-Risk Siblings; n=21). Hierarchical linear modeling indicated that High-Risk Siblings exhibited lower levels of baseline RJA and IJA and a lower rate of linear change in IBR than Low-Risk Siblings. When the 10 High-Risk Siblings who received an ASD diagnosis were excluded from analyses, group differences in the development of referential communication remained significant only for RJA. Baseline levels of IJA were associated with later ASD symptomatology among High-Risk Siblings, suggesting that individual differences in referential communication development at 8months may index early manifestations of ASD.
C1 [Ibanez, Lisa V.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
[Ibanez, Lisa V.] Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA.
[Grantz, Caroline J.; Messinger, Daniel S.] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
[Messinger, Daniel S.] Univ Miami, Dept Pediat, Coral Gables, FL 33124 USA.
[Messinger, Daniel S.] Univ Miami, Dept Elect & Comp Engn, Coral Gables, FL 33124 USA.
RP Ibanez, LV (reprint author), Univ Washington, Autism Ctr, CHDD, POB 357920, Seattle, WA 98195 USA.
EM libanez1@uw.edu
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NR 49
TC 2
Z9 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1525-0008
J9 INFANCY
JI Infancy
PD SEP
PY 2013
VL 18
IS 5
BP 687
EP 707
DI 10.1111/j.1532-7078.2012.00142.x
PG 21
WC Psychology, Developmental
SC Psychology
GA 201UF
UT WOS:000323167800003
ER
PT J
AU Jordan, K
King, M
Hellersteth, S
Wiren, A
Mulligan, H
AF Jordan, Kimberlee
King, Marcus
Hellersteth, Sophia
Wiren, Anna
Mulligan, Hilda
TI Feasibility of using a humanoid robot for enhancing attention and social
skills in adolescents with autism spectrum disorder
SO INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
LA English
DT Article
DE autism spectrum disorder; education; robot
ID CHILDREN
AB This study investigated the use of robotic technology for promoting attention, communication and social skills in adolescents with autism spectrum disorder (ASD). Attention, communication and social skills were measured while participants played a memory card matching game (Face Match) using (a) a humanoid robot, (b) a Smart Board and (c) playing cards. Three participants with ASD and three with other cognitive impairments were recruited from a secondary school with a special needs unit. Participants were paired such that one of each pair had a diagnosis of ASD and Face Match was played in these pairs for similar to 15 min, with a game organizer present. On 3 separate days, video recordings were made as the participants played Face Match; a different game mode (robot, Smart Board, playing cards) was used each day. A system for categorizing attention, communication and social skills was developed that described 16 subcategories of interactions and intra-actions. In general, participants with ASD showed highly individualized patterns of behaviour in the three different modes. However, repetitive behaviour was reduced in participants with ASD when using both the robot and the Smart Board compared with playing cards. We show that it is feasible to use a robot to assist teaching of social skills to adolescents with ASD, but suggest that the robot features could be further explored and utilized. (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Jordan, Kimberlee; King, Marcus] Univ Otago, Ind Res Ltd, Christchurch, New Zealand.
[Mulligan, Hilda] Univ Otago, Sch Physiotherapy, Christchurch, New Zealand.
[Hellersteth, Sophia; Wiren, Anna] Umea Univ, Dept Community Med & Rehabil, Stockholm, Sweden.
RP Jordan, K (reprint author), Ind Res Ltd, POB 20028, Christchurch 8543, New Zealand.
EM k.jordan@irl.cri.nz
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NR 10
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0342-5282
EI 1473-5660
J9 INT J REHABIL RES
JI Int. J. Rehabil. Res.
PD SEP
PY 2013
VL 36
IS 3
BP 221
EP 227
DI 10.1097/MRR.0b013e32835d0b43
PG 7
WC Rehabilitation
SC Rehabilitation
GA 202LZ
UT WOS:000323219400005
PM 23328816
ER
PT J
AU Huang, AX
Jia, MX
Wheeler, JJ
AF Huang, Ann X.
Jia, Meixiang
Wheeler, John J.
TI Children with Autism in the People's Republic of China: Diagnosis, Legal
Issues, and Educational Services
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Diagnosis; Special educational services;
Legal issues; Behavioral intervention/management; Chinese autism
AB Since the late 1970s, special education in the People's Republic of China has experienced significant reform and fast development. However, education for children with severe developmental disabilities, especially autism spectrum disorders (ASDs), is still the greatest challenge in the field. This paper aims to give readers an overview of what is happening to children with ASDs in China. We first address the issue of prevalence of ASDs, and then offer an introduction to the diagnostic process. After that, a review of disability-related legislation is provided, followed by a description of current treatment options and available educational services. Finally we introduce all extent service providers and their roles.
C1 [Huang, Ann X.] Duquesne Univ, Sch Educ, Dept Counseling Psychol & Special Educ, Pittsburgh, PA 15282 USA.
[Jia, Meixiang] Beijing Univ, Inst Mental Hlth, Sch Med, Beijing 100871, Peoples R China.
[Wheeler, John J.] E Tennessee State Univ, Claudius G Clemmer Coll Educ, Ctr Excellence Early Childhood Learn & Dev, Johnson City, TN 37614 USA.
RP Huang, AX (reprint author), Duquesne Univ, Sch Educ, Dept Counseling Psychol & Special Educ, 600 Forbes Ave, Pittsburgh, PA 15282 USA.
EM huanga2840@duq.edu
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NR 36
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 1991
EP 2001
DI 10.1007/s10803-012-1722-6
PG 11
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100001
PM 23179346
ER
PT J
AU Daley, TC
Singhal, N
Krishnamurthy, V
AF Daley, Tamara C.
Singhal, Nidhi
Krishnamurthy, Vibha
TI Ethical Considerations in Conducting Research on Autism Spectrum
Disorders in Low and Middle Income Countries
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Ethics; Cross-cultural; ELSI; LMIC; LAMI;
Global; India
ID PERVASIVE DEVELOPMENTAL DISORDERS; INTELLECTUAL DISABILITY;
CHILD-DEVELOPMENT; THERAPEUTIC MISCONCEPTION; INFORMED-CONSENT;
EPIDEMIOLOGY; KNOWLEDGE; SCIENCE; ISSUES; INDIA
AB Autism spectrum disorder (ASD) is being identified in an ever-increasing number of countries, including many that are low or middle income (LMIC). Research conducted in these countries requires awareness of unique ethical issues. Drawing on the experience of two organizations that have been involved in conducting and collaborating in ASD research in India, we describe specific considerations in conducting epidemiological, genetic and treatment studies as well as general principles from the field of multinational clinical research as they apply to the conduct of ASD research. We argue that greater attention to ethical concerns will result in quality studies conducted in LMICs that are also of greatest relevance for families and children with ASD.
C1 [Daley, Tamara C.] Westat Corp, Durham, NC 27703 USA.
[Singhal, Nidhi] Act Autism Natl Ctr Autism, New Delhi 110015, India.
[Krishnamurthy, Vibha] Ummeed Child Dev Ctr, Bombay 400011, Maharashtra, India.
RP Daley, TC (reprint author), Westat Corp, 1009 Slater Rd,Suite 110, Durham, NC 27703 USA.
EM tamaradaley@westat.com
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NR 105
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2002
EP 2014
DI 10.1007/s10803-012-1750-2
PG 13
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100002
PM 23283629
ER
PT J
AU Doggett, RA
Krasno, AM
Koegel, LK
Koegel, RL
AF Doggett, Rebecca A.
Krasno, Anna M.
Koegel, Lynn Kern
Koegel, Robert L.
TI Acquisition of Multiple Questions in the Context of Social Conversation
in Children with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Intervention; Conversation; Question-asking; Communication;
Self-management
ID SPECTRUM DISORDERS; WH-QUESTIONS; COMMUNICATION; ASKING; INFORMATION;
INTERVENTIONS; INDIVIDUALS; BEHAVIOR
AB Verbal initiations, such as questions, are essential components of social conversation often lacking in children with autism. Building on research showing that single questions can be taught in isolation, this study used a multiple baseline design to investigate whether a self-management intervention was effective for teaching concurrent acquisition and discrimination of three social questions in the context of conversation. Following intervention, participants rapidly increased their appropriate use of all three questions in a conversational context and maintained these gains over time. The participants also used questions appropriately with partners uninvolved in treatment. Additionally, the occasional presence of appropriate questions during baseline coupled with rapid improvement during intervention support theories that a lack of question-asking may be motivation-based rather than ability-based.
C1 [Doggett, Rebecca A.; Krasno, Anna M.; Koegel, Lynn Kern; Koegel, Robert L.] Univ Calif Santa Barbara, Counseling Clin & Sch Psychol Dept, Santa Barbara, CA 93106 USA.
[Doggett, Rebecca A.; Krasno, Anna M.; Koegel, Lynn Kern; Koegel, Robert L.] Univ Calif Santa Barbara, Koegel Autism Ctr, Santa Barbara, CA 93106 USA.
RP Koegel, RL (reprint author), Univ Calif Santa Barbara, Counseling Clin & Sch Psychol Dept, Santa Barbara, CA 93106 USA.
EM koegel@education.ucsb.edu
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NR 49
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2015
EP 2025
DI 10.1007/s10803-012-1749-8
PG 11
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100003
PM 23292139
ER
PT J
AU Froehlich, W
Cleveland, S
Torres, A
Phillips, J
Cohen, B
Torigoe, T
Miller, J
Fedele, A
Collins, J
Smith, K
Lotspeich, L
Croen, LA
Ozonoff, S
Lajonchere, C
Grether, JK
Hallmayer, J
AF Froehlich, Wendy
Cleveland, Sue
Torres, Andrea
Phillips, Jennifer
Cohen, Brianne
Torigoe, Tiffany
Miller, Janet
Fedele, Angie
Collins, Jack
Smith, Karen
Lotspeich, Linda
Croen, Lisa A.
Ozonoff, Sally
Lajonchere, Clara
Grether, Judith K.
Hallmayer, Joachim
TI Head Circumferences in Twins With and Without Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Macrocephaly; Head circumference; Twins; Endophenotype; Genetics
ID PERVASIVE DEVELOPMENTAL DISORDERS; BRAIN-DEVELOPMENT; DIAGNOSTIC
INTERVIEW; ADAPTIVE-BEHAVIOR; 1ST YEAR; CHILDREN; GROWTH; AGE; IQ;
HERITABILITY
AB To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4-18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs.
C1 [Froehlich, Wendy; Cleveland, Sue; Torres, Andrea; Phillips, Jennifer; Lotspeich, Linda; Hallmayer, Joachim] Stanford Univ, Sch Med, Dept Psychiat, Stanford, CA 94305 USA.
[Cohen, Brianne; Torigoe, Tiffany; Miller, Janet; Fedele, Angie; Lajonchere, Clara] Autism Speaks, Clin Programs, Autism Genet Resource Exchange, Los Angeles, CA 90036 USA.
[Collins, Jack; Grether, Judith K.] Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, Environm Hlth Invest Branch, Richmond, CA 94804 USA.
[Smith, Karen] Impact Assessment Inc, La Jolla, CA 92037 USA.
[Ozonoff, Sally] Univ Calif, Davis Med Invest Neurodev Disorders Inst, Sacramento, CA 95817 USA.
[Hallmayer, Joachim] Stanford Univ, Stanford, CA 94304 USA.
RP Froehlich, W (reprint author), Stanford Univ, Sch Med, Dept Psychiat, 401 Quarry Rd,MC 5719, Stanford, CA 94305 USA.
EM wendyf@stanford.edu
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NR 52
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2026
EP 2037
DI 10.1007/s10803-012-1751-1
PG 12
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100004
PM 23321801
ER
PT J
AU Massand, E
Bowler, DM
Mottron, L
Hosein, A
Jemel, B
AF Massand, Esha
Bowler, Dermot M.
Mottron, Laurent
Hosein, Anthony
Jemel, Boutheina
TI ERP Correlates of Recognition Memory in Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Memory; Autism spectrum disorder; Event-related potential; Recognition;
Old/new effect
ID EVENT-RELATED POTENTIALS; HIGH-FREQUENCY WORDS; ASPERGERS-SYNDROME;
BRAIN POTENTIALS; FREE-RECALL; ELECTROPHYSIOLOGICAL EVIDENCE;
RECOLLECTIVE EXPERIENCE; CONSCIOUS AWARENESS; UNFAMILIAR FACES; EPISODIC
MEMORY
AB Recognition memory in autism spectrum disorder (ASD) tends to be undiminished compared to that of typically developing (TD) individuals (Bowler et al. 2007), but it is still unknown whether memory in ASD relies on qualitatively similar or different neurophysiology. We sought to explore the neural activity underlying recognition by employing the old/new word repetition event-related potential effect. Behavioural recognition performance was comparable across both groups, and demonstrated superior recognition for low frequency over high frequency words. However, the ASD group showed a parietal rather than anterior onset (300-500 ms), and diminished right frontal old/new effects (800-1500 ms) relative to TD individuals. This study shows that undiminished recognition performance results from a pattern of differing functional neurophysiology in ASD.
C1 [Massand, Esha; Bowler, Dermot M.] City Univ London, Dept Psychol, Autism Res Grp, London EC1V 0HB, England.
[Mottron, Laurent; Hosein, Anthony; Jemel, Boutheina] Univ Montreal, Hop Riviere des Prairies, Montreal, PQ, Canada.
RP Massand, E (reprint author), Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA.
EM emassand@u.washington.edu
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NR 64
TC 4
Z9 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2038
EP 2047
DI 10.1007/s10803-012-1755-x
PG 10
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100005
PM 23307419
ER
PT J
AU Naigles, LR
Kelley, E
Troyb, E
Fein, D
AF Naigles, Letitia R.
Kelley, Elizabeth
Troyb, Eva
Fein, Deborah
TI Residual Difficulties with Categorical Induction in Children with a
History of Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Optimal outcome; Categorical induction; Semantics; Pragmatics
ID SPECTRUM DISORDERS; LANGUAGE IMPAIRMENT; BASIC-LEVEL; CATEGORIZATION;
INDIVIDUALS
AB In two experiments, typically developing (TD) children, high-functioning children with autism (HFA) and children with a history of autism who have achieved optimal outcomes (OOs), matched on age (M = 13 years) and nonverbal IQ, were asked to extend properties of categories to new items (categorical induction). All groups demonstrated some knowledge of category structure by extending at above-chance levels; however, the TD group extended more consistently than the OO and HFA groups. More consistent extenders had higher lexical and nonverbal IQ scores (Experiment 1) or higher pragmatics scores (Experiment 2). Thus, even very high functioning individuals with autism, or with an OO, still exhibit residual difficulties with category knowledge and extension; moreover, category tasks relate to a variety of verbal and nonverbal abilities. The difficulty these groups had with categorical induction may be related to their difficulty with generalization more widely; future research should investigate this possibility.
C1 [Naigles, Letitia R.; Kelley, Elizabeth; Troyb, Eva; Fein, Deborah] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA.
RP Naigles, LR (reprint author), Univ Connecticut, Dept Psychol, 406 Babbidge Rd U-1020, Storrs, CT 06269 USA.
EM letitia.naigles@uconn.edu
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NR 38
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2048
EP 2061
DI 10.1007/s10803-012-1754-y
PG 14
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100006
PM 23321802
ER
PT J
AU McGonigle-Chalmers, M
Alderson-Day, B
Fleming, J
Monsen, K
AF McGonigle-Chalmers, Maggie
Alderson-Day, Ben
Fleming, Joanna
Monsen, Karl
TI Profound Expressive Language Impairment in Low Functioning Children with
Autism: An Investigation of Syntactic Awareness Using a Computerised
Learning Task
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Expressive language impairment; Low-functioning autism; Syntax;
Executive control
ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; SIGN LANGUAGE;
COMMUNICATION; ACQUISITION; SPEECH; SYNCHRONIZATION; INTERVENTION;
REGRESSION
AB Nine low-functioning children with profound expressive language impairment and autism were studied in terms of their responsiveness to a computer-based learning program designed to assess syntactic awareness. The children learned to touch words on a screen in the correct sequence in order to see a corresponding animation, such as 'monkey flies'. The game progressed in levels from 2 to 4 word sequences, contingent upon success at each stage. Although performance was highly variable across participants, a detailed review of their learning profiles suggested that no child lacked syntactic awareness and that elementary syntactic control in a non-speech domain was superior to that manifest in their spoken language. The reasons for production failures at the level of speech in children with autism are discussed.
C1 [McGonigle-Chalmers, Maggie; Alderson-Day, Ben; Fleming, Joanna; Monsen, Karl] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9QU, Midlothian, Scotland.
[Monsen, Karl] Univ Edinburgh, Dept Informat, Edinburgh EH8 9QU, Midlothian, Scotland.
RP McGonigle-Chalmers, M (reprint author), Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9QU, Midlothian, Scotland.
EM M.McGonigle@ed.ac.uk
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NR 47
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2062
EP 2081
DI 10.1007/s10803-012-1753-z
PG 20
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100007
PM 23292162
ER
PT J
AU Pickles, A
Parr, JR
Rutter, ML
De Jonge, MV
Wallace, S
Le Couteur, AS
van Engeland, H
Wittemeyer, K
McConachie, H
Roge, B
Mantoulan, C
Pedersen, L
Isager, T
Poustka, F
Bolte, S
Bolton, P
Weisblatt, E
Green, J
Papanikolaou, K
Bailey, AJ
AF Pickles, A.
Parr, J. R.
Rutter, M. L.
De Jonge, M. V.
Wallace, S.
Le Couteur, A. S.
van Engeland, H.
Wittemeyer, K.
McConachie, H.
Roge, B.
Mantoulan, C.
Pedersen, L.
Isager, T.
Poustka, F.
Bolte, S.
Bolton, P.
Weisblatt, E.
Green, J.
Papanikolaou, K.
Bailey, A. J.
TI New Interview and Observation Measures of the Broader Autism Phenotype:
Impressions of Interviewee Measure
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Broader autism phenotype; Observer rating; Test-retest; Factor analysis;
Social functioning
ID FAMILY-HISTORY; PARENTS; INDIVIDUALS; DISORDERS; SPECTRUM; CHILDREN
AB A 20 item observational measure of social functioning, the Impression of Interviewee rating scale, is one of three measures devised to assess the broader autism phenotype. The sample studied included families containing at least two individuals with autism spectrum disorder; observations were undertaken by the researcher who interviewed the subject. An exploratory factor analysis suggested a single factor was most appropriate (Cronbach's alpha of 0.78). There was a modest but significant retest correlation of 0.42. Correlations between live ratings and blind consensus ratings of vignettes were high (0.93). Correlations with the interview measures were moderate but statistically significant. In conclusion, the observational scale provides a promising start but further work is required before general use can be recommended.
C1 [Pickles, A.] Kings Coll London, Dept Biostat, Inst Psychiat, London, England.
[Parr, J. R.; Wallace, S.; Wittemeyer, K.; Bailey, A. J.] Univ Oxford, Dept Psychiat, Oxford, England.
[Parr, J. R.; Le Couteur, A. S.; McConachie, H.] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Parr, J. R.; Le Couteur, A. S.; McConachie, H.] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Rutter, M. L.] Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, London, England.
[De Jonge, M. V.; van Engeland, H.] Dept Child Psychiat, Utrecht, Netherlands.
[Roge, B.; Mantoulan, C.] Ctr Etud & Rech Psychopathol, Toulouse, France.
[Pedersen, L.; Isager, T.] Ctr Autisme, Copenhagen, Denmark.
[Poustka, F.; Bolte, S.] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60054 Frankfurt, Germany.
[Bolte, S.] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
[Bolton, P.] Kings Coll London, Dept Child & Adolescent Psychiat, Inst Psychiat, London, England.
[Weisblatt, E.] Univ Cambridge, Cambridge Lab Res Autism, Cambridge, England.
[Weisblatt, E.] Cambridgeshire & Peterborough Fdn NHS Trust, Peterborough Integrated Child Hlth Serv, Peterborough, Cambs, England.
[Green, J.] Univ Manchester, Acad Dept Child Psychiat, Manchester, Lancs, England.
[Papanikolaou, K.] Univ Dept Child Psychiat, Athens, Greece.
[Bailey, A. J.] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
RP Pickles, A (reprint author), Kings Coll London, Dept Biostat, Inst Psychiat, London, England.
EM andrew.pickles@kcl.ac.uk
RI Bolton, Patrick/E-8501-2010; Bailey, Anthony/J-2860-2014; Pickles,
Andrew/A-9625-2011
OI Bolton, Patrick/0000-0002-5270-6262; Bailey,
Anthony/0000-0003-4257-972X; Pickles, Andrew/0000-0003-1283-0346
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StataCorp, 2011, STAT STAT SOFTW REL
NR 24
TC 3
Z9 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2082
EP 2089
DI 10.1007/s10803-013-1810-2
PG 8
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100008
PM 23547019
ER
PT J
AU Jones, L
Totsika, V
Hastings, RP
Petalas, MA
AF Jones, Leah
Totsika, Vasiliki
Hastings, Richard P.
Petalas, Michael A.
TI Gender Differences When Parenting Children with Autism Spectrum
Disorders: A Multilevel Modeling Approach
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder (ASD); Mothers; Fathers; Families;
Psychological well-being; Multilevel linear modeling (MLM)
ID PERVASIVE DEVELOPMENTAL DISORDERS; MATERNAL MENTAL-HEALTH; BEHAVIOR
PROBLEMS; INTELLECTUAL DISABILITY; PRESCHOOL-CHILDREN;
EMOTIONAL-PROBLEMS; DOWN-SYNDROME; PSYCHOLOGICAL ADJUSTMENT; POSITIVE
PERCEPTIONS; SYNDROME SPECIFICITY
AB Parenting a child with autism may differentially affect mothers and fathers. Existing studies of mother-father differences often ignore the interdependence of data within families. We investigated gender differences within-families using multilevel linear modeling. Mothers and fathers of children with autism (161 couples) reported on their own well-being, and their child's functioning. Mothers reported higher levels of distress compared with fathers, and child behavior problems predicted psychological distress for both mothers and fathers. We found little evidence of child functioning variables affecting mothers and fathers differently. Gender differences in the impact of child autism on parents appear to be robust. More family systems research is required to fully understand these gender differences and the implications for family support.
C1 [Jones, Leah; Totsika, Vasiliki; Hastings, Richard P.; Petalas, Michael A.] Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
RP Jones, L (reprint author), Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
EM leah.jones@bangor.ac.uk
RI Hastings, Richard/D-9657-2013
OI Hastings, Richard/0000-0002-0495-8270
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NR 61
TC 7
Z9 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2090
EP 2098
DI 10.1007/s10803-012-1756-9
PG 9
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100009
PM 23307420
ER
PT J
AU Doi, H
Fujisawa, TX
Kanai, C
Ohta, H
Yokoi, H
Iwanami, A
Kato, N
Shinohara, K
AF Doi, Hirokazu
Fujisawa, Takashi X.
Kanai, Chieko
Ohta, Haruhisa
Yokoi, Hideki
Iwanami, Akira
Kato, Nobumasa
Shinohara, Kazuyuki
TI Recognition of Facial Expressions and Prosodic Cues with Graded
Emotional Intensities in Adults with Asperger Syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Facial expression; Prosody; Inversion effect; Configural processing;
Asperger syndrome
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM; EXPERT OBJECT
RECOGNITION; FACE-PROCESSING DEFICIT; SEX-DIFFERENCES; PERCEPTION;
CHILDREN; ADOLESCENTS; INDIVIDUALS; INFORMATION
AB This study investigated the ability of adults with Asperger syndrome to recognize emotional categories of facial expressions and emotional prosodies with graded emotional intensities. The individuals with Asperger syndrome showed poorer recognition performance for angry and sad expressions from both facial and vocal information. The group difference in facial expression recognition was prominent for stimuli with low or intermediate emotional intensities. In contrast to this, the individuals with Asperger syndrome exhibited lower recognition accuracy than typically-developed controls mainly for emotional prosody with high emotional intensity. In facial expression recognition, Asperger and control groups showed an inversion effect for all categories. The magnitude of this effect was less in the Asperger group for angry and sad expressions, presumably attributable to reduced recruitment of the configural mode of face processing. The individuals with Asperger syndrome outperformed the control participants in recognizing inverted sad expressions, indicating enhanced processing of local facial information representing sad emotion. These results suggest that the adults with Asperger syndrome rely on modality-specific strategies in emotion recognition from facial expression and prosodic information.
C1 [Doi, Hirokazu; Fujisawa, Takashi X.; Shinohara, Kazuyuki] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528523, Japan.
[Kanai, Chieko; Ohta, Haruhisa; Yokoi, Hideki; Iwanami, Akira; Kato, Nobumasa] Showa Univ, Sch Med, Dept Psychiat, Tokyo 142, Japan.
RP Shinohara, K (reprint author), Nagasaki Univ, Grad Sch Biomed Sci, 1-12-4 Sakamoto Cho, Nagasaki 8528523, Japan.
EM kazuyuki@nagasaki-u.ac.jp
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NR 86
TC 6
Z9 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2099
EP 2113
DI 10.1007/s10803-013-1760-8
PG 15
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100010
PM 23371506
ER
PT J
AU Curtin, S
Vouloumanos, A
AF Curtin, Suzanne
Vouloumanos, Athena
TI Speech Preference is Associated with Autistic-Like Behavior in
18-Months-Olds at Risk for Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Speech preference; Language development; High-risk infant siblings;
Autism spectrum disorders
ID INFANT-DIRECTED SPEECH; RECURRENCE RISK; SOCIAL-STIMULI; GAZE BEHAVIOR;
CHILDREN; LANGUAGE; BIRTH; RECOGNITION; PERCEPTION; ATTENTION
AB We examined whether infants' preference for speech at 12 months is associated with autistic-like behaviors at 18 months in infants who are at increased risk for autism spectrum disorder (ASD) because they have an older sibling diagnosed with ASD and in low-risk infants. Only low-risk infants listened significantly longer to speech than to nonspeech at 12 months. In both groups, relative preference for speech correlated positively with general cognitive ability at 12 months. However, in high-risk infants only, preference for speech was associated with autistic-like behavior at 18 months, while in low-risk infants, preference for speech correlated with language abilities. This suggests that in children at risk for ASD an atypical species-specific bias for speech may underlie atypical social development.
C1 [Curtin, Suzanne] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
[Vouloumanos, Athena] NYU, Dept Psychol, New York, NY 10003 USA.
RP Curtin, S (reprint author), Univ Calgary, Dept Psychol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM scurtin@ucalgary.ca; athena.vouloumanos@nyu.edu
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NR 44
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2114
EP 2120
DI 10.1007/s10803-013-1759-1
PG 7
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100011
PM 23334808
ER
PT J
AU Koegel, R
Kim, S
Koegel, L
Schwartzman, B
AF Koegel, Robert
Kim, Sunny
Koegel, Lynn
Schwartzman, Ben
TI Improving Socialization for High School Students with ASD by Using Their
Preferred Interests
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Social; High school; Autism spectrum disorders; Inclusion
ID AUTISM SPECTRUM DISORDERS; SOCIAL-SKILLS; YOUNG-CHILDREN; INTERVENTION;
ADOLESCENTS; PEERS; SETTINGS; DISABILITIES; DEPRESSION; BEHAVIORS
AB There has been a paucity of research on effective social interventions for adolescents with autism spectrum disorders (ASD) in inclusive high school settings. The literature, however, suggests that incorporating the student with ASD's special interests into activities may help improve their socialization with typical peers. Within the context of a multiple baseline across participants design, we implemented lunchtime activities incorporating the adolescent with ASD's preferred interests that were similar to ongoing activities already available at the schools. Results showed this increased both level of engagement and their rate of initiations made to typical peers. Social validation measures suggest that both adolescents with ASD and typical peers enjoyed participating in these activities and that the results generalized to other similar activities.
C1 [Koegel, Robert; Kim, Sunny; Koegel, Lynn] Univ Calif Santa Barbara, Grad Sch Educ, Koegel Autism Ctr, Santa Barbara, CA 93106 USA.
RP Koegel, R (reprint author), Univ Calif Santa Barbara, Grad Sch Educ, Koegel Autism Ctr, Santa Barbara, CA 93106 USA.
EM koegel@education.ucsb.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 46
TC 7
Z9 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2121
EP 2134
DI 10.1007/s10803-013-1765-3
PG 14
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100012
PM 23361918
ER
PT J
AU Renno, P
Wood, JJ
AF Renno, Patricia
Wood, Jeffrey J.
TI Discriminant and Convergent Validity of the Anxiety Construct in
Children with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Anxiety; Autism spectrum disorder; Discriminant validity; Construct
validity
ID PERVASIVE DEVELOPMENTAL DISORDERS; MISSING DATA; PSYCHIATRIC-DISORDERS;
ASPERGER-SYNDROME; YOUTH; SYMPTOMS; ADOLESCENTS; RELIABILITY;
VALIDATION; SCHEDULE
AB Despite reports of high anxiety in children with autism spectrum disorders (ASD), there is controversy regarding differential diagnosis of ASD symptoms and anxiety symptoms. This study examined 88 children, aged 7-11 years, with ASD referred for concerns about anxiety. A multitrait-(social anxiety, separation anxiety, overall anxiety severity, and overall ASD severity), multimethod-(diagnostic interviews, parent-, and child-based measures) analysis was conducted. Results from structural equation modeling suggest statistical discrimination between anxiety and ASD severity and convergence among differing reports of two of the anxiety subdomains (separation anxiety and overall anxiety). These findings suggest that anxiety symptoms experienced by children with ASD are separate from ASD symptom severity and may instead reflect anxiety syndromes (e.g., separation anxiety) similar to those that occur in typically developing children.
C1 [Renno, Patricia; Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Educ, Los Angeles, CA 90095 USA.
[Wood, Jeffrey J.] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA.
RP Renno, P (reprint author), Univ Calif Los Angeles, Dept Educ, Moore Hall, Los Angeles, CA 90095 USA.
EM prenno@ucla.edu
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NR 57
TC 10
Z9 10
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2135
EP 2146
DI 10.1007/s10803-013-1767-1
PG 12
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100013
PM 23354538
ER
PT J
AU May, T
Rinehart, N
Wilding, J
Cornish, K
AF May, Tamara
Rinehart, Nicole
Wilding, John
Cornish, Kim
TI The Role of Attention in the Academic Attainment of Children with Autism
Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Academic; Autism spectrum disorder; Reading; Mathematics; Attention
switching; Sustained attention
ID HIGH-FUNCTIONING AUTISM; EXECUTIVE FUNCTION; PSYCHIATRIC-DISORDERS;
ASPERGER-SYNDROME; VISUAL-SEARCH; PERFORMANCE; ADHD; ADOLESCENTS;
ACHIEVEMENT; SYMPTOMS
AB Academic attainment in children with Autism Spectrum Disorder (ASD) is under-studied, with associated factors largely undetermined. Parent-reported attention symptoms, attentional-switching and sustained-attention tasks were examined to determine relationships with mathematics and reading attainment in 124 children aged 7-12 years; sixty-four with high-functioning ASD, half girls, and sixty age- and gender-matched typical children (TYP). With full-scale IQ controlled there were no differences in mathematics, reading, attentional switching or sustained attention. In regression analysis, attentional switching was related to mathematics achievement in ASD but not TYP children. Findings highlight attentional switching difficulties are linked with poorer mathematics outcomes in ASD.
C1 [May, Tamara; Rinehart, Nicole] Monash Univ, Sch Psychol & Psychiat, Ctr Dev Psychiat & Psychol, Notting Hill, Vic 3168, Australia.
[Wilding, John] Univ London, Egham TW20 0EX, Surrey, England.
[Cornish, Kim] Monash Univ, Sch Psychol & Psychiat, Clayton, Vic 3800, Australia.
RP May, T (reprint author), Monash Univ, Sch Psychol & Psychiat, Ctr Dev Psychiat & Psychol, Bldg 1,270 Ferntree Gully Rd, Notting Hill, Vic 3168, Australia.
EM tamara.may@monash.edu; kim.cornish@monash.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 58
TC 5
Z9 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2147
EP 2158
DI 10.1007/s10803-013-1766-2
PG 12
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100014
PM 23378062
ER
PT J
AU Sharp, WG
Berry, RC
McCracken, C
Nuhu, NN
Marvel, E
Saulnier, CA
Klin, A
Jones, W
Jaquess, DL
AF Sharp, William G.
Berry, Rashelle C.
McCracken, Courtney
Nuhu, Nadrat N.
Marvel, Elizabeth
Saulnier, Celine A.
Klin, Ami
Jones, Warren
Jaquess, David L.
TI Feeding Problems and Nutrient Intake in Children with Autism Spectrum
Disorders: A Meta-analysis and Comprehensive Review of the Literature
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Review
DE Diet; Food selectivity; Mealtime problems; Nutrition; Picky eating;
Pediatric feeding disorders
ID TYPICALLY DEVELOPING-CHILDREN; PERVASIVE DEVELOPMENTAL DISORDERS;
CASEIN-FREE DIET; QUANTITATIVE SYNTHESIS; PRESCHOOL-CHILDREN; MEALTIME
BEHAVIORS; TREATMENT OUTCOMES; EATING BEHAVIORS; GLUTEN-FREE;
INDIVIDUALS
AB We conducted a comprehensive review and meta-analysis of research regarding feeding problems and nutrient status among children with autism spectrum disorders (ASD). The systematic search yielded 17 prospective studies involving a comparison group. Using rigorous meta-analysis techniques, we calculated the standardized mean difference (SMD) with standard error and corresponding odds ratio (OR) with 95 % confidence intervals (CI). Results indicated children with ASD experienced significantly more feeding problems versus peers, with an overall SMD of 0.89 (0.08) and a corresponding OR of 5.11, 95 % CI 3.74-6.97. Nutrient analyses indicated significantly lower intake of calcium (SMD: -0.65 [0.29]; OR: 0.31, 95 % CI 0.11-0.85) and protein (SMD: -0.58 [0.25]; OR: 0.35, 95 % CI: 0.14-0.56) in ASD. Future research must address critical questions regarding the cause, long-term impact, and remediation of atypical feeding in this population.
C1 [Sharp, William G.; McCracken, Courtney; Saulnier, Celine A.; Klin, Ami; Jones, Warren; Jaquess, David L.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA.
[Sharp, William G.; Berry, Rashelle C.; Nuhu, Nadrat N.; Marvel, Elizabeth; Saulnier, Celine A.; Klin, Ami; Jones, Warren; Jaquess, David L.] Marcus Autism Ctr, Atlanta, GA 30329 USA.
RP Sharp, WG (reprint author), Marcus Autism Ctr, 1920 Briarcliff Rd, Atlanta, GA 30329 USA.
EM wgsharp@emory.edu
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NR 57
TC 11
Z9 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2159
EP 2173
DI 10.1007/s10803-013-1771-5
PG 15
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100015
PM 23371510
ER
PT J
AU Murdock, LC
Ganz, J
Crittendon, J
AF Murdock, Linda C.
Ganz, Jennifer
Crittendon, Jessica
TI Use of an iPad Play Story to Increase Play Dialogue of Preschoolers with
Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Language; Play; Intervention; Scripting; Computer-based
intervention
ID HIGH-FUNCTIONING CHILDREN; COMPUTER-ANIMATED TUTOR; SINGLE-CASE
RESEARCH; PRETEND PLAY; SOCIODRAMATIC PLAY; JOINT ATTENTION; VIDEO
MODELS; COMMUNICATION; SKILLS; STUDENTS
AB An iPad play story was utilized to increase the pretend play skills of 4 preschoolers with autism spectrum disorders. The story utilized a series of video clips depicting toy figures producing scripted character dialogue, engaged in a pretend play vignette. A multiple baseline design across participants was utilized with play dialogue as the dependent variable. Three of the participants demonstrated increases in the target behavior with Nonoverlap of All Pairs analysis revealing moderate and strong effects across intervention phases. Effects were largely maintained during generalization opportunities with peers and during a 3-week follow-up condition.
C1 [Murdock, Linda C.] Univ Montevallo, Dept CSD, Stn 6720, Montevallo, AL 35115 USA.
[Ganz, Jennifer] Texas A&M Univ, Dept Educ Psychol, Coll Educ & Human Dev, College Stn, TX 77843 USA.
[Crittendon, Jessica] Mitchells Pl, Birmingham, AL 35210 USA.
RP Murdock, LC (reprint author), Univ Montevallo, Dept CSD, Stn 6720, Montevallo, AL 35115 USA.
EM murdocklc@montevallo.edu; Jeniganz@tamu.edu;
jcrittenden@mitchells-place.com
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Zimmerman I. L., 2011, PRESCHOOL LANGUAGE S
NR 60
TC 8
Z9 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2174
EP 2189
DI 10.1007/s10803-013-1770-6
PG 16
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100016
PM 23371509
ER
PT J
AU Ward, SC
Whalon, K
Rusnak, K
Wendell, K
Paschall, N
AF Ward, Sandra C.
Whalon, Kelly
Rusnak, Katrina
Wendell, Kimberly
Paschall, Nancy
TI The Association Between Therapeutic Horseback Riding and the Social
Communication and Sensory Reactions of Children with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Autism spectrum disorder; Therapeutic horseback riding; Animal
assisted therapy
AB This study investigated the association between therapeutic riding (TR) and the social communication and sensory processing skills of 21 elementary students with autism attending TR as part of a school group. An interrupted treatment design was employed to determine whether children were able to maintain treatment effects following the removal of TR. Teacher ratings indicated that participating children with autism significantly increased their social interaction, improved their sensory processing, and decreased the severity of symptoms associated with autism spectrum disorders following TR. Gains were not maintained consistently after two 6-week breaks from TR, but were recovered once TR was reinstated. Potential explanations regarding the benefits of TR are discussed, and suggestions for future research provided.
C1 [Ward, Sandra C.; Whalon, Kelly] Coll William & Mary, Sch Educ, Williamsburg, VA 23185 USA.
[Rusnak, Katrina; Wendell, Kimberly; Paschall, Nancy] Cori Sikich Therapeut Riding Ctr, Dream Catchers, Toano, VA USA.
RP Ward, SC (reprint author), Coll William & Mary, Sch Educ, 301 Monticello Ave, Williamsburg, VA 23185 USA.
EM sandra.ward@wm.edu
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Ward S. C., 2011, SAN FRANC CA ANN M N
NR 26
TC 2
Z9 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD SEP
PY 2013
VL 43
IS 9
BP 2190
EP 2198
DI 10.1007/s10803-013-1773-3
PG 9
WC Psychology, Developmental
SC Psychology
GA 202XD
UT WOS:000323253100017
PM 23371511
ER
EF