FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Mog, A
AF Mog, Ashley
TI Understanding Autism: Parents, Doctors, and the History of a Disorder
SO ORAL HISTORY REVIEW
LA English
DT Book Review
C1 [Mog, Ashley] Univ Kansas, Lawrence, KS 66045 USA.
RP Mog, A (reprint author), Univ Kansas, Lawrence, KS 66045 USA.
CR Silverman C, 2012, UNDERSTANDING AUTISM: PARENTS, DOCTORS, AND THE HISTORY OF A DISORDER, P1
NR 1
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0094-0798
EI 1533-8592
J9 ORAL HIST REV
JI Oral Hist. Rev.
PD WIN-SPR
PY 2015
VL 42
IS 1
BP 170
EP 172
PG 4
WC History
SC History
GA CI9MG
UT WOS:000355093600017
ER
PT J
AU Abdulla, AM
Hegde, AM
AF Abdulla, A. M.
Hegde, A. M.
TI Salivary Cortisol Levels and its Implication on Behavior In Children
with Autism during Dental Treatment
SO JOURNAL OF CLINICAL PEDIATRIC DENTISTRY
LA English
DT Article
DE Autism; Cortisol; Stress; Diurnal Variation; children
ID STRESS
AB The aim of the study was to estimate the diurnal variations of salivary cortisol in children with autism and healthy children and it's implication on behavior during non-invasive dental procedures. Study design: 50 children with autism and 50 healthy children in the age group between 6 to 12 years of both genders with the need for dental treatment were included in the study Whole unstimulated saliva was collected from them during early hours of the day and during evenings for 2 consecutive days. The collected saliva was then subjected to electrochemiluminescence assay. Minimum invasive dental procedures like hand scaling, pit and fissure sealants and glass ionomer cement restorations were performed for the participants each time after the saliva sample collection and their behavior during the procedures was rated using Frankl's Behavior Rating Scale. Results:Significant correlation was seen between cortisol levels and behavior in children with autism. As cortisol levels increased in children with autism, behavior worsened and as the cortisol levels decreased they showed positive behaviour Conclusion: Cortisol acts as a stress marker and studying the diurnal variations of salivary cortisol can help us in attaining better knowledge about the behavior pattern and thereby assist us in modiffing the behavior modification procedures and treatment planning in this group of special children.
C1 [Abdulla, A. M.; Hegde, A. M.] Nitte Univ, Dept Pedodont & Prevent Dent, AB Shetty Mem Inst Dent Sci, Mangalore 575018, Karnataka, India.
RP Abdulla, AM (reprint author), Nitte Univ, Dept Pedodont & Prevent Dent, AB Shetty Mem Inst Dent Sci, Mangalore 575018, Karnataka, India.
EM anshad2004@gmail.com
RI ahmed, Jamila/E-8653-2015
CR Aardal E, 1995, EUR J CLIN CHEM CLIN, V33, P927
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FDI Working Group 10 CORE, 1992, INT DENT J, V42, P291
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Vandettin B, 2009, AUSTR J BASIC APPL S, V3, P1013
World Health Organization, 2006, F84 PERV DEV DIS, V10th
NR 18
TC 0
Z9 0
PU JOURNAL PEDODONTICS INC
PI BIRMINGHAM
PA 5724 HIGHWAY 280 EAST, BIRMINGHAM, AL 35242 USA
SN 1053-4628
EI 1557-5268
J9 J CLIN PEDIATR DENT
JI J. Clin. Pediatr. Dent.
PD WIN
PY 2015
VL 39
IS 2
BP 128
EP 132
PG 5
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA CG6SW
UT WOS:000353433700009
PM 25823482
ER
PT J
AU Simplican, SC
AF Simplican, Stacy Clifford
TI Care, Disability, and Violence: Theorizing Complex Dependency in Eva
Kittay and Judith Butler
SO HYPATIA-A JOURNAL OF FEMINIST PHILOSOPHY
LA English
DT Article
ID BEHAVIOR PROBLEMS; CHILDREN; STRESS
AB How do we theorize the experiences of caregivers abused by their children with autism without intensifying stigma toward disability? Eva Kittay emphasizes examples of extreme vulnerability to overturn myths of independence, but she ignores the possibility that dependents with disabilities may be vulnerable and aggressive. Instead, her work over-emphasizes care-givers' capabilities and the constancy of disabled dependents' vulnerability. I turn to Judith Butler's ethics and her conception of the self as opaque to rethink care amid conflict. Person-centered planning approaches, pioneered by disability rights activists, merge Butler's analysis of opacity with Kittay's work on embodied care, while also inviting a broader network of people to both interpret needs and change communities. By expanding our conceptions of dependency, feminist disability studies can continue the aim of both Kittay and Butler: to humanize unintelligible lives.
C1 [Simplican, Stacy Clifford] Michigan State Univ, E Lansing, MI 48824 USA.
[Simplican, Stacy Clifford] DOCTRID Res Inst, Dublin, Ireland.
RP Simplican, SC (reprint author), Michigan State Univ, E Lansing, MI 48824 USA.
EM cliffosa@msu.edu
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Kittay Eva Feder, 2013, REGULATING FAMILY RE
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NR 37
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-5367
EI 1527-2001
J9 HYPATIA
JI Hypatia
PD WIN
PY 2015
VL 30
IS 1
SI SI
BP 217
EP 233
DI 10.1111/hypa.12130
PG 17
WC Philosophy; Women's Studies
SC Philosophy; Women's Studies
GA CA2BC
UT WOS:000348712900014
ER
PT J
AU Bagatell, N
Mason, AE
AF Bagatell, Nancy
Mason, Ashley E.
TI Looking Backward, Thinking Forward: Occupational Therapy and Autism
Spectrum Disorders
SO OTJR-OCCUPATION PARTICIPATION AND HEALTH
LA English
DT Article
DE autism spectrum disorders; literature review; occupational therapy
ID SENSORY INTEGRATION; YOUNG-CHILDREN; BEHAVIORS; MOTOR; PARTICIPATION;
INTERVENTIONS; DESIGN; ADOLESCENTS; FAMILIES; SERVICE
AB As autism spectrum disorders become more prevalent and comprise a growing percentage of occupational therapists' caseloads, it is important to examine trends in the literature. The purpose of this scoping review is to provide a historical analysis to illuminate changes and gaps in the occupational therapy literature related to autism spectrum disorders to inform the direction of research and practice. A total of 115 articles published in five occupational therapy journals in the United States from 1980 to 2013 were reviewed. Publications were coded by article type, with intervention studies coded in detail. Results indicated a consistent increase in number of publications as years progressed. Analysis by decade highlighted a shift from a biomedical focus to an occupation focus. Suggestions for future research include building a stronger evidence base, developing occupation-based assessments and interventions, and addressing needs of individuals with autism spectrum disorders and their families across the life span.
C1 [Bagatell, Nancy; Mason, Ashley E.] Univ N Carolina, Chapel Hill, NC 27599 USA.
RP Bagatell, N (reprint author), Univ N Carolina, Div Occupat Sci & Occupat Therapy, Bondurant Hall,CB 7122, Chapel Hill, NC 27599 USA.
EM nancy_bagatell@med.unc.edu
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NR 51
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1539-4492
EI 1938-2383
J9 OTJR-OCCUP PART HEAL
JI OTJR-Occup. Particip. Health
PD WIN
PY 2015
VL 35
IS 1
BP 34
EP 41
DI 10.1177/1539449214557795
PG 8
WC Rehabilitation
SC Rehabilitation
GA CB4UA
UT WOS:000349622500004
ER
PT J
AU Bakan, MB
AF Bakan, Michael B.
TI "Don't Go Changing to Try and Please Me": Combating Essentialism through
Ethnography in the Ethnomusicology of Autism
SO ETHNOMUSICOLOGY
LA English
DT Article
ID MUSIC-THERAPY; SPECTRUM DISORDER; CHILDREN; COMMUNICATION; CULTURE;
NOTIONS; ABILITY
AB Ethnomusicology is the study of how people make and experience music, and of why it matters to them that they do. Building from the epistemological foundations of the autistic self-advocacy and neurodiversity movements, as well as from the musical, ethnographic, and relativistic priorities of ethnomusicology itself, this article advances the position that our field, thus defined, is inherently well suited to the task of creating and sustaining vital, neurodiverse musical communities. The focus is on one such community; the Artism Ensemble, which serves as the basis of a case study featuring transcripts of dialogue with a child member of the group diagnosed with Asperger's syndrome.
C1 Florida State Univ, Coll Mus, Tallahassee, FL 32306 USA.
RP Bakan, MB (reprint author), Florida State Univ, Coll Mus, Tallahassee, FL 32306 USA.
CR Aigen Kenneth, 2002, PLAYIN BAND QUALITAT
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American Psychiatric Association, 2013, AUT SPECTR DIS DSM 5
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 74
TC 0
Z9 0
PU SOC ETHNOMUSICOLOGY INC
PI BLOOMINGTON
PA MORRISON HALL, ROOM 005 INDIANA UNIVERSITY, BLOOMINGTON, IN 47405 USA
SN 0014-1836
EI 2156-7417
J9 ETHNOMUSICOLOGY
JI Ethnomusicology
PD WIN
PY 2015
VL 59
IS 1
BP 116
EP 144
PG 29
WC Music
SC Music
GA CA5QY
UT WOS:000348964100006
ER
PT J
AU Willey, A
Subramaniam, B
Hamilton, JA
Couperus, J
AF Willey, Angela
Subramaniam, Banu
Hamilton, Jennifer A.
Couperus, Jane
TI The Mating Life of Geeks: Love, Neuroscience, and the New Autistic
Subject
SO SIGNS
LA English
DT Article
ID SPECTRUM DISORDERS; MIND; OXYTOCIN; INTERSEX; DEFICITS; GENDER; BRAIN;
SEX
AB In this article, we track the emergence of a new autistic subject, one that is socially inept yet brilliant, earnest yet charming, obsessive yet humorous, arrogant yet vulnerable, and unquestionably worthy of our attention. In contrast to the historic definition of the autist as one lacking the capacity for love, the new autistic subject is enabled and inflected by the gendered construction of autism spectrum disorder (ASD) and holds the promise of being potentially productive and even (desirably) reproductive. Through an analysis of current trends in autism science (extreme male brains and assortative mating) and shifting narratives about autism and love, we trace how processes of heterosexualization inform the shift from loveless to loving and lovable, and we further explore how such processes produce new forms of exclusions in the name of neurodiversity. We locate ASD as a site for the reinscription and biologization of historical ideas about gender as well as the naturalization of normative heterosexuality. Finally, we argue that it is through this process of normalization via heterosexualization that this new subject emerges, leaving many lost to the queer, to the feminine, or to the irredeemably abject.
C1 [Willey, Angela; Subramaniam, Banu] Univ Massachusetts, Amherst, MA 01003 USA.
[Hamilton, Jennifer A.] Hampshire Coll, Sch Crit Social Inquiry, Amherst, MA 01002 USA.
[Couperus, Jane] Hampshire Coll, Sch Cognit Sci, Amherst, MA 01002 USA.
RP Willey, A (reprint author), Univ Massachusetts, Amherst, MA 01003 USA.
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NR 85
TC 0
Z9 0
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0097-9740
EI 1545-6943
J9 SIGNS
JI Signs
PD WIN
PY 2015
VL 40
IS 2
BP 369
EP 391
DI 10.1086/678146
PG 23
WC Women's Studies
SC Women's Studies
GA AW7YD
UT WOS:000346476600009
ER
PT J
AU Bie, BJ
Tang, L
AF Bie, Bijie
Tang, Lu
TI Representation of Autism in Leading Newspapers in China: A Content
Analysis
SO HEALTH COMMUNICATION
LA English
DT Article
ID NEWS COVERAGE; MEDIA; INFORMATION; CANCER
AB The public's lack of understanding and the public's misconceptions about autism in China contribute to the underdiagnosis and undertreatment of the disorder and the stigma associated with it. Mass media are the primary channel through which people learn about autism. This article examines how leading newspapers in China covered autism in the 10-year period of 2003 through 2012 through a framing analysis. It finds that while autism has received increased media attention, it is increasingly framed as a family problem-family members are cited or quoted more than any other sources and the responsibility of dealing with autism is ultimately assigned to families. Autistic people are largely silenced unless they are autistic savants with special talents. The use of the scientific discourse and the human-interest discourse both decrease over time in percentage, while the use of other discourses such as the public relations discourse becomes more dominant.
C1 [Bie, Bijie] Univ Alabama, Coll Commun & Informat Sci, Tuscaloosa, AL 35487 USA.
[Tang, Lu] Univ Alabama, Coll Commun & Informat Sci, Dept Commun Studies, Tuscaloosa, AL 35487 USA.
RP Tang, L (reprint author), Univ Alabama, Coll Commun & Informat Sci, Dept Commun Studies, Tuscaloosa, AL 35487 USA.
EM ltang1@ua.edu
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NR 37
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1041-0236
EI 1532-7027
J9 HEALTH COMMUN
JI Health Commun.
PD SEP 2
PY 2015
VL 30
IS 9
BP 884
EP 893
DI 10.1080/10410236.2014.889063
PG 10
WC Communication; Health Policy & Services
SC Communication; Health Care Sciences & Services
GA CH4ZM
UT WOS:000354043300004
PM 25074820
ER
PT J
AU Burket, JA
Benson, AD
Green, TL
Rook, JM
Lindsley, CW
Conn, PJ
Deutsch, SI
AF Burket, Jessica A.
Benson, Andrew D.
Green, Torrian L.
Rook, Jerri M.
Lindsley, Craig W.
Conn, P. Jeffrey
Deutsch, Stephen I.
TI Effects of VU0410120, a novel GlyT1 inhibitor, on measures of
sociability, cognition and stereotypic behaviors in a mouse model of
autism
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism Spectrum Disorders; Balb/c; GlyT1 inhibition; NMDA receptor
ID CYCLOSERINE IMPROVES SOCIABILITY; NMDA RECEPTORS; BALB/C MOUSE; SPECTRUM
DISORDERS; STRAINS DIFFER; MICE; SCHIZOPHRENIA; RELEVANT; MK-801;
EXCITABILITY
AB The NMDA receptor is a highly regulated glutamate-gated cationic channel receptor that has an important role in the regulation of sociability and cognition. The genetically-inbred Balb/c mouse has altered endogenous tone of NMDA receptor-mediated neurotransmission and is a model of impaired sociability, relevant to Autism Spectrum Disorders (ASDs). Because glycine is an obligatory co-agonist that works cooperatively with glutamate to promote opening of the ion channel, one prominent strategy to promote NMDA receptor-mediated neurotransmission involves inhibition of the glycine type 1 transporter (GlyT1). The current study evaluated the dose-dependent effects of VU0410120, a selective, high-affinity competitive GlyT1 inhibitor, on measures of sociability, cognition and stereotypic behaviors in Balb/c and Swiss Webster mice. The data show that doses of VU0410120 (i.e., 18 and 30 mg/kg) that improve measures of sociability and spatial working memory in the Balb/c mouse strain elicit intense stereotypic behaviors in the Swiss Webster comparator strain (i.e., burrowing and jumping). Furthermore, the data suggest that selective GlyT1 inhibition improves sociability and spatial working memory at doses that do not worsen or elicit stereotypic behaviors in a social situation in the Balb/c strain. However, the elicitation of stereotypic behaviors in the Swiss Webster comparator strain at therapeutically relevant doses of VU0410120 suggest that genetic factors (i.e., mouse strain differences) influence sensitivity to GlyT1-elicited stereotypic behaviors, and emergence of intense stereotypic behaviors may be dose-limiting side effects of this interventional strategy. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Burket, Jessica A.; Benson, Andrew D.; Green, Torrian L.; Deutsch, Stephen I.] Eastern Virginia Med Sch, Dept Psychiat & Behav Sci, Norfolk, VA 23501 USA.
[Rook, Jerri M.; Lindsley, Craig W.; Conn, P. Jeffrey] Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Neurosci Drug Discovery, Nashville, TN 37235 USA.
RP Deutsch, SI (reprint author), Dept Psychiat & Behav Sci, 825 Fairfax Ave,Suite 710, Norfolk, VA 23507 USA.
EM deutscsi@evms.edu
FU Bristol Myers Squibb; Astrazeneca
FX PJ Conn and CW Lindsley receive research support from Bristol Myers
Squibb and Astrazeneca and are inventors on multiple patents protecting
GlyT1 inhibitors. JA Burket, AD Benson, TL Green, JM Rook, and SI
Deutsch have nothing to disclose.
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NR 37
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 3
PY 2015
VL 61
BP 10
EP 17
DI 10.1016/j.pnpbp.2015.03.003
PG 8
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CI2VM
UT WOS:000354605500002
PM 25784602
ER
PT J
AU Sekine, K
Matsune, S
Shiiba, K
Kimura, M
Okubo, K
Kaneshiro, T
Tajima, H
Murakami, M
Kurokawa, A
AF Sekine, Kuwon
Matsune, Shoji
Shiiba, Kyoko
Kimura, Maki
Okubo, Kimihiro
Kaneshiro, Tadashi
Tajima, Hiroyuki
Murakami, Masahiro
Kurokawa, Akira
TI Treatment of nostril and nasal stenosis due to facial burn using a
self-expandable metallic esophageal stent
SO AURIS NASUS LARYNX
LA English
DT Article
DE Nostril stenosis; Nasal stenosis; Facial burn; Self-expandable metallic
stent
ID RECONSTRUCTION
AB For the treatment of nasal and nostril stenosis caused by facial burn, it is necessary to perform rhinoplasty and nasal vestibuloplasty using various flaps, perform cicatrectomy of the nostrils with a rhinosurgical procedure, and prevent restenosis of the nostrils and nasal cavity for a certain period by methods such as placement of a nasal retainer or transnasal airway and gauze packing of the nasal cavity. With all methods, postoperative placement of a retainer or nasal treatment is necessary for the prevention of postoperative restenosis, and the patient's cooperation is essential.
In a patient who did not cooperate in postoperative treatments due to autism and had recurrences of nasal and nostril stenosis after conventional surgical treatments, adequate patency of the nasal cavity and nostrils could be maintained with minimal postoperative treatment by placing a self-expandable metallic esophageal stent. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Sekine, Kuwon; Matsune, Shoji; Kimura, Maki] Nippon Med Sch Musashikosugi Hosp, Dept Otolaryngol, Kawasaki, Kanagawa, Japan.
[Shiiba, Kyoko] Nozawa Otolaryngol Clin, Tokyo, Japan.
[Okubo, Kimihiro] Nippon Med Sch, Grad Sch Med, Dept Head & Neck & Sensory Organ Sci, Tokyo 113, Japan.
[Kaneshiro, Tadashi; Tajima, Hiroyuki] Nippon Med Sch Musashikosugi Hosp, Ctr Minimally Invas Treatment, Kawasaki, Kanagawa, Japan.
[Murakami, Masahiro] Nippon Med Sch Musashikosugi Hosp, Dept Plast & Reconstruct Surg, Kawasaki, Kanagawa, Japan.
[Kurokawa, Akira] Nippon Med Sch Musashikosugi Hosp, Kawasaki, Kanagawa, Japan.
RP Sekine, K (reprint author), Nippon Med Sch Musashikosugi Hosp, Dept Otolaryngol, Kawasaki, Kanagawa, Japan.
EM kuwon@nms.ac.jp
CR Copcu E, 2005, BURNS, V31, P802, DOI 10.1016/j.burns.2005.04.025
Daya M, 2009, J PLAST RECONSTR AES, V62, P1012, DOI 10.1016/j.bjps.2007.11.066
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Zou T, 2014, J MECH BEHAV BIOMED, V38, P17, DOI 10.1016/j.jmbbm.2014.06.004
NR 10
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0385-8146
EI 1879-1476
J9 AURIS NASUS LARYNX
JI Auris Nasus Larynx
PD AUG
PY 2015
VL 42
IS 4
BP 348
EP 352
DI 10.1016/j.anl.2015.02.013
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA CJ3DO
UT WOS:000355363800017
PM 25748514
ER
PT J
AU Clarke, RP
AF Clarke, Robin P.
TI Rising-falling mercury pollution causing the rising-falling IQ of the
Lynn-Flynn effect, as predicted by the antiinnatia theory of autism and
IQ
SO PERSONALITY AND INDIVIDUAL DIFFERENCES
LA English
DT Article
DE Autism; Air pollution; Mercury; Flynn effect; IQ
ID SEYCHELLES CHILD-DEVELOPMENT; METHYLMERCURY EXPOSURE; FISH CONSUMPTION;
TEST-SCORES; INTELLIGENCE; DEPOSITION; DNA
AB A fundamental principle of the antiinnatia theory of autism and IQ is that the same factors (genetic and environmental) which in extreme high levels cause autism, in more modal levels cause increased IQ. And the factors which generally cause raised IQ, in extreme levels cause autism. The antiinnatia theory further proposed that molecules randomly part-time binding to DNA and thereby reducing gene-expression would cause autism (and in less high levels cause raised IQ). Studies have found that mercury binds dose-dependently to DNA thereby reducing gene-expression, and thus the theory predicts that mercury pollution would cause raised IQ (such as the Flynn effect). This appears contrary to the standard assumption that mercury pollution causes decrements of IQ In this study, data from the Upper Fremont glacier finds considerable overall correspondence between changes of mercury pollution and changes of IQ, In respect of both mercury and IQ there was roughly-speaking 100 years of increase followed by 15 years of decrease in at least five countries. But mercury pollution is likely to be causing serious harms other than decrements of population averages of IQ. (C) 2015 Elsevier Ltd. All rights reserved.
C1 Autism Causes Ctr, Birmingham B18 7DB, W Midlands, England.
RP Clarke, RP (reprint author), Autism Causes Ctr, 115 Salisbury Tower, Birmingham B18 7DB, W Midlands, England.
EM rpclarke@autismcauses.info
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NR 29
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0191-8869
J9 PERS INDIV DIFFER
JI Pers. Individ. Differ.
PD AUG
PY 2015
VL 82
BP 46
EP 51
DI 10.1016/j.paid.2015.02.039
PG 6
WC Psychology, Social
SC Psychology
GA CH6OZ
UT WOS:000354157200008
ER
PT J
AU Byrd-Craven, J
Massey, AR
Calvi, JL
Geary, DC
AF Byrd-Craven, Jennifer
Massey, Amber R.
Calvi, Jessica L.
Geary, David C.
TI Is systemizing a feature of the extreme,male brain from an evolutionary
perspective?
SO PERSONALITY AND INDIVIDUAL DIFFERENCES
LA English
DT Article
DE Sex differences; Extreme male brain; Empathizing; Systemizing
ID DIGIT RATIO 2D/4D; SEX-DIFFERENCES; ASPERGER-SYNDROME; AUTISM; EMPATHY;
METAANALYSIS; ABILITIES; BEHAVIOR; ADULTS
AB Sex differences in empathizing with others and systemizing the abstract rules that govern the operation of things and the natural world have been proposed as the core, essential differences between men and women. We evaluate this assertion in the context of Darwin's (1871) sexual selection and specifically test the hypothesis that the systemizing measure captures interest in evolutionarily novel occupational niches associated with interests in science, technology, engineering, and mathematics (STEM). Young adults (n = 233, 149 male) completed the Empathizing Quotient (EQ), the Systemizing Quotient (SQ) and the RIASEC Personality Type Inventory to assess six career interest groups. Sex differences were found on the EQ, SQ Investigative interests and interest in things, a subset of items from the Realistic scale. Mediation analyses revealed that occupational interests partially mediated the relation between sex and SQ scores, whereas controlling for Investigative interests increased the sex difference in EQ scores. These results provide partial support for the hypothesis and suggest SQ captures, in part, occupational interests in evolutionarily recent STEM fields. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Byrd-Craven, Jennifer; Massey, Amber R.; Calvi, Jessica L.] Oklahoma State Univ, Stillwater, OK 74078 USA.
[Geary, David C.] Univ Missouri, Columbia, MO 65211 USA.
RP Byrd-Craven, J (reprint author), Oklahoma State Univ, 116 North Murray Hall, Stillwater, OK 74078 USA.
EM jennifer.byrd.craven@okstate.edu; mas-seya@okstate.edu;
calvi@okstate.edu; GearyD@Missouri.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Andersson MB, 1994, SEXUAL SELECTION
Armstrong PI, 2008, J VOCAT BEHAV, V73, P287, DOI 10.1016/j.jvb.2008.06.003
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Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY
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Centers for Disease Control and Prevention, 2012, AUT DEV DIS MON NETW
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Darwin C., 1871, DESCENT MAN SELECTIO
Davis M. H., 1980, DISS ABSTR INT, V40, P3480
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Geary D. C., 2007, PSYCHOL PERSPECTIVES, V2, p[1, 177]
Geary D. C., 2010, MALE FEMALE EVOLUTIO, V2nd
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Holland J. L., 1997, MAKING VOCATIONAL CH
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NR 41
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0191-8869
J9 PERS INDIV DIFFER
JI Pers. Individ. Differ.
PD AUG
PY 2015
VL 82
BP 237
EP 241
DI 10.1016/j.paid.2015.03.026
PG 5
WC Psychology, Social
SC Psychology
GA CH6OZ
UT WOS:000354157200041
ER
PT J
AU Wright, C
AF Wright, C.
TI Research in partnership: principles for good practice for involving
young people with autism in research
SO BRITISH JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Meeting Abstract
DE Children and families; Participation; Research
C1 [Wright, C.] Bradford Dist Care Trust, Child & Adolescent Mental Hlth Serv, Bradford, W Yorkshire, England.
EM catherine.wright@bdct.nhs.uk
CR Baron-Cohen S, 2009, PREVALENCE OF AUTISM
Clavering EK, 2010, CHILD CARE HLTH DEV, V36, P603, DOI 10.1111/j.1365-2214.2010.01094.x
Holloway I, 2010, QUALITATIVE RESEARCH
NR 3
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0308-0226
EI 1477-6006
J9 BRIT J OCCUP THER
JI Br. J. Occup. Ther.
PD AUG
PY 2015
VL 77
SU 1
MA 48.2
BP 40
EP 41
PG 2
WC Rehabilitation
SC Rehabilitation
GA CF1KB
UT WOS:000352302900085
ER
PT J
AU McCanney, J
Kelly, G
Casey, J
Cross, S
McCaffrey, F
AF McCanney, J.
Kelly, G.
Casey, J.
Cross, S.
McCaffrey, F.
TI Sensory processing patterns and activity choices of children with and
without autism
SO BRITISH JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Meeting Abstract
DE Children and families; Participation; Occupational science
C1 [McCanney, J.; Cross, S.; McCaffrey, F.] Middletown Ctr Autism, Armagh, North Ireland.
[Kelly, G.; Casey, J.] Univ Ulster, Coleraine BT52 1SA, Londonderry, North Ireland.
EM jill.mccanney@middletownautism.com
CR American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
Ayres A. J., 2005, SENSORY INTEGRATION, V25th
Bundy A., 2002, SENSORY INTEGRATION
Mattard-Labrecque Carolanne, 2013, J Can Acad Child Adolesc Psychiatry, V22, P139
Tseng MH, 2011, RES AUTISM SPECT DIS, V5, P1441, DOI 10.1016/j.rasd.2011.02.004
NR 5
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0308-0226
EI 1477-6006
J9 BRIT J OCCUP THER
JI Br. J. Occup. Ther.
PD AUG
PY 2015
VL 77
SU 1
MA P35
BP 90
EP 90
PG 1
WC Rehabilitation
SC Rehabilitation
GA CF1KB
UT WOS:000352302900186
ER
PT J
AU Barbu, E
Martin-Valdivia, MT
Martinez-Camara, E
Urena-Lopez, LA
AF Barbu, Eduard
Teresa Martin-Valdivia, M.
Martinez-Camara, Eugenio
Alfonso Urena-Lopez, L.
TI Language technologies applied to document simplification for helping
autistic people
SO EXPERT SYSTEMS WITH APPLICATIONS
LA English
DT Article
DE Natural Language Processing; Text simplification; ASD; Image retrieval;
Text summarization; Topic Models; Idiom detection
ID SPECTRUM DISORDERS; READING-COMPREHENSION; CHILDREN; STUDENTS;
DISABILITIES
AB People affected by Autism Spectrum Disorders (ASD) have impairments in social interaction because they lack an adequate theory of mind. A significant percentile has inadequate reading comprehension skills. We present a multilingual tool called Open Book (OB) that applies Human Language Technologies (HLT) in order to identify reading comprehension obstacles in text documents and propose more simple alternatives with the aim of assisting the reading comprehension of users. OB involves several text transformations at lexical, syntactic and semantic level. In this paper we focus on three challenging components of the OB tool: the image retrieval component, the idiom detection component and the summarization module. There are very few studies that involve simplification by showing images associated to difficult concepts. In addition, the treatment of figurative language such as idioms or metaphors is one of the most challenging areas in Natural Language Processing (NLP). Finally, although text summarization is a more widely studied field in NLP, its application to text simplification remains as an open research issue. Thus, we focus on the integration of these three modules in our OB tool. We present the motivation for building these components and we describe how they are integrated in the whole system. Moreover, the usability and the usefulness of OB have been evaluated and analysed showing that the tool helps to produce texts easier to understand for autistic people. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Barbu, Eduard; Teresa Martin-Valdivia, M.; Martinez-Camara, Eugenio; Alfonso Urena-Lopez, L.] Univ Jaen, SINAI Res Grp, E-23071 Jaen, Spain.
RP Martinez-Camara, E (reprint author), Univ Jaen, SINAI Res Grp, Campus Las Lagunillas, E-23071 Jaen, Spain.
EM eduard_barbu@yahoo.com; maite@ujaen.es; emcamara@ujaen.es;
laurena@ujaen.es
FU Fondo Europeo de Desarrollo Regional (FEDER); ATTOS project from the
Spanish Government [TIN2012-38536-C03-0]; project AORESCU from the
regional government of Junta de Andalucia [P11-TIC-7684 MO]; University
of Jaen [CEATIC-2013-001]; European Commission under the Seventh (FP7)
Framework Program for Research and Technological Development through the
FIRST project [FP7-287607]
FX This work has been partially supported by a Grant from the Fondo Europeo
de Desarrollo Regional (FEDER), ATTOS project (TIN2012-38536-C03-0) from
the Spanish Government. The project AORESCU (P11-TIC-7684 MO) from the
regional government of Junta de Andalucia and the project
CEATIC-2013-001 from the University of Jaen partially supports this
manuscript. The work in this paper is partially funded by the European
Commission under the Seventh (FP7-2007-2013) Framework Program for
Research and Technological Development through the FIRST project
(FP7-287607). This publication reflects only the views of the authors,
and the Commission cannot be held responsible for any use which may be
made of the information contained therein.
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NR 43
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0957-4174
EI 1873-6793
J9 EXPERT SYST APPL
JI Expert Syst. Appl.
PD JUL 15
PY 2015
VL 42
IS 12
BP 5076
EP 5086
DI 10.1016/j.eswa.2015.02.044
PG 11
WC Computer Science, Artificial Intelligence; Engineering, Electrical &
Electronic; Operations Research & Management Science
SC Computer Science; Engineering; Operations Research & Management Science
GA CH0XY
UT WOS:000353746900006
ER
PT J
AU Perry, A
Levy-Gigi, E
Richter-Levin, G
Shamay-Tsoory, SG
AF Perry, Anat
Levy-Gigi, Einat
Richter-Levin, Gal
Shamay-Tsoory, Simone G.
TI Interpersonal distance and social anxiety in autistic spectrum
disorders: A behavioral and ERP study
SO SOCIAL NEUROSCIENCE
LA English
DT Article
DE N1 ERP; Autism; Personal space; Interpersonal distance
ID HIGH-FUNCTIONING CHILDREN; EVENT-RELATED POTENTIALS; PSYCHOMETRIC
PROPERTIES; ASPERGER-SYNDROME; BRAIN POTENTIALS; SCALE; ATTENTION;
ADULTS; RESPONSIVENESS; ADOLESCENTS
AB An inherent feature of social interactions is the use of social space or interpersonal distance-the space between one individual and another. Because social deficits are core symptoms of Autistic Spectrum Disorder (ASD), we hypothesized that individuals on this spectrum will exhibit abnormal interpersonal distance preferences. The literature on interpersonal distance in ASD is not conclusive. While some studies show preferences for closer distances among this group, others show preferences for farther distances than controls. A common symptom of ASD that may explain the variance in responses to interpersonal distance in this population is social anxiety (SA), which has been shown to correlate with interpersonal distance preferences. In the current study, we investigated interpersonal distance preferences in a group of individuals with ASD using both behavioral and ERP measures. We found greater variance in interpersonal distance preferences in the ASD group than in the control group. Furthermore, we showed that this variance can be explained by differences in SA level and can be predicted by the N1 amplitude, an early ERP component related to attention and discrimination processes. These results hint at the early sensory and attentional processes that may be affecting higher social behaviors, both in subclinical and in clinical populations.
C1 [Perry, Anat; Shamay-Tsoory, Simone G.] Univ Haifa, Dept Psychol, IL-31999 Haifa, Israel.
[Levy-Gigi, Einat; Richter-Levin, Gal] Univ Haifa, Inst Study Affect Neurosci, IL-31999 Haifa, Israel.
RP Perry, A (reprint author), Univ Calif Berkeley, Knight Lab, 132 Barker Hall, Berkeley, CA 94720 USA.
EM anat.perry@berkeley.edu
RI ahmed, Jamila/E-8653-2015
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NR 52
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1747-0919
EI 1747-0927
J9 SOC NEUROSCI-UK
JI Soc. Neurosci.
PD JUL 4
PY 2015
VL 10
IS 4
BP 354
EP 365
DI 10.1080/17470919.2015.1010740
PG 12
WC Neurosciences; Psychology
SC Neurosciences & Neurology; Psychology
GA CH6BU
UT WOS:000354121500003
PM 25666260
ER
PT J
AU Burket, JA
Benson, AD
Tang, AH
Deutsch, SI
AF Burket, Jessica A.
Benson, Andrew D.
Tang, Amy H.
Deutsch, Stephen I.
TI NMDA receptor activation regulates sociability by its effect on mTOR
signaling activity
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE D-Cycloserine; mTOR; NMDA receptor; Sociability; Tuberous sclerosis
ID AUTISM SPECTRUM DISORDERS; CYCLOSERINE IMPROVES SOCIABILITY;
POSTTRAUMATIC-STRESS-DISORDER; TYROSINE-PHOSPHATASE STEP; MOUSE STRAINS
DIFFER; FRAGILE-X-SYNDROME; BTBR-T+TF/J MICE; TUBEROUS SCLEROSIS;
SOCIAL-BEHAVIOR; BALB/C MOUSE
AB Tuberous Sclerosis Complex is one example of a syndromic form of autism spectrum disorder associated with disinhibited activity of mTORC1 in neurons (e.g., cerebellar Purkinje cells). mTORC1 is a complex protein possessing serine/threonine kinase activity and a key downstream molecule in a signaling cascade beginning at the cell surface with the transduction of neurotransmitters (e.g., glutamate and acetylcholine) and nerve growth factors (e.g., Brain-Derived Neurotrophic Factor). Interestingly, the severity of the intellectual disability in Tuberous Sclerosis Complex may relate more to this metabolic disturbance (i.e., overactivity of mTOR signaling) than the density of cortical tubers. Several recent reports showed that rapamycin, an inhibitor of mTORC1, improved sociability and other symptoms in mouse models of Tuberous Sclerosis Complex and autism spectrum disorder, consistent with mTORC1 overactivity playing an important pathogenic role. NMDA receptor activation may also dampen mTORC1 activity by at least two possible mechanisms: regulating intraneuronal accumulation of arginine and the phosphorylation status of a specific extracellular signal regulating kinase (i.e., ERK1/2), both of which are "drivers" of mTORC1 activity. Conceivably, the prosocial effects of targeting the NMDA receptor with agonists in mouse models of autism spectrum disorders result from their ability to dampen mTORC1 activity in neurons. Strategies for dampening mTORC1 overactivity by NMDA receptor activation may be preferred to its direct inhibition in chronic neurodevelopmental disorders, such as autism spectrum disorders. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Burket, Jessica A.; Benson, Andrew D.; Deutsch, Stephen I.] Eastern Virginia Med Sch, Dept Psychiat & Behav Sci, Norfolk, VA 23501 USA.
[Tang, Amy H.] Eastern Virginia Med Sch, Dept Microbiol & Mol Cell Biol, Norfolk, VA 23501 USA.
RP Deutsch, SI (reprint author), Dept Psychiat & Behav Sci, 825 Fairfax Ave,Suite 710, Norfolk, VA 23507 USA.
EM deutscsi@evms.edu
FU Virginia's Commonwealth Health Research Board; Office of the Dean of
Eastern Virginia Medical School
FX The authors acknowledge the support they received from grant funding
from Virginia's Commonwealth Health Research Board. The authors also
acknowledge the support they received from the Office of the Dean of
Eastern Virginia Medical School.
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NR 58
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUL 3
PY 2015
VL 60
BP 60
EP 65
DI 10.1016/j.pnpbp.2015.02.009
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CH4ST
UT WOS:000354023900007
ER
PT J
AU Shafritz, KM
Bregman, JD
Ikuta, T
Szeszko, PR
AF Shafritz, Keith M.
Bregman, Joel D.
Ikuta, Toshikazu
Szeszko, Philip R.
TI Neural systems mediating decision-making and response inhibition for
social and nonsocial stimuli in autism
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorder; Cognition; Emotion; Executive function; fMRI
ID FUNCTIONAL MAGNETIC-RESONANCE; SPECTRUM DISORDERS; ASPERGER-SYNDROME;
BEHAVIORAL-RESPONSE; SPATIAL ATTENTION; BIPOLAR DISORDER; FUSIFORM
GYRUS; COGNITIVE SET; FACIAL AFFECT; GO/NO-GO
AB Autism is marked by impairments in social reciprocity and communication, along with restricted, repetitive and stereotyped behaviors. Prior studies have separately investigated social processing and executive function in autism, but little is known about the brain mechanisms of cognitive control for both emotional and nonemotional stimuli. We used functional magnetic resonance imaging to identify differences in neurocircuitry between individuals with high functioning autism (HFA) and neurotypical controls during two versions of a go/no-go task: emotional (fear and happy faces) and nonemotional (English letters). During the letter task, HFA participants showed hypoactivation in the ventral prefrontal cortex. During the emotion task, happy faces elicited activation in the ventral striatum, nucleus accumbens and anterior amygdala in neurotypical, but not HFA, participants. Response inhibition for fear faces compared with happy faces recruited occipitotemporal regions in HFA, but not neurotypical, participants. In a direct contrast of emotional no-go and letter no-go blocks, HFA participants showed hyperactivation in extrastriate cortex and fusiform gyrus. Accuracy for emotional no-go trials was negatively correlated with activation in fusiform gyrus in the HFA group. These results indicate that autism is associated with abnormal processing in socioemotional brain networks, and support the theory that autism is marked by a social motivational deficit. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Shafritz, Keith M.] Dept Psychol, Hempstead, NY 11549 USA.
[Shafritz, Keith M.; Bregman, Joel D.; Szeszko, Philip R.] North Shore LIJ Hlth Syst, Feinstein Inst Med Res, Manhasset, NY 11030 USA.
[Ikuta, Toshikazu] Univ Mississippi, Dept Commun Sci & Disorders, University, MS 38677 USA.
[Szeszko, Philip R.] Zucker Hillside Hosp, Psychiat Res, Glen Oaks, NY 11004 USA.
[Szeszko, Philip R.] Hofstra North Shore LIJ Sch Med, Hempstead, NY 11549 USA.
[Bregman, Joel D.] Ctr Autism, Philadelphia, PA 19131 USA.
RP Shafritz, KM (reprint author), Dept Psychol, 135 Hofstra Univ, Hempstead, NY 11549 USA.
EM keith.shafritz@hofstra.edu
FU National Institutes of Health [M01RR018535]; Hofstra University
FX We thank Linda Spritzer, Melissa Buchman, Rachel Ginsberg, and Elizabeth
Mansdorf for help with subject recruitment, cognitive test
administration, and data analysis; Dr. Peter Kingsley and John
Ferrannini for technical assistance with MRI data collection; Blair
Shevlin and Cori Fisher for help with paradigm development and fMRI data
analysis. This study was funded by National Institutes of Health Grant
M01RR018535 and grants from Hofstra University. The authors declare no
competing financial interests.
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NR 53
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUL 3
PY 2015
VL 60
BP 112
EP 120
DI 10.1016/j.pnpbp.2015.03.001
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CH4ST
UT WOS:000354023900012
PM 25765593
ER
PT J
AU Engineer, CT
Rahebi, KC
Buell, EP
Fink, MK
Kilgard, MP
AF Engineer, Crystal T.
Rahebi, Kimiya C.
Buell, Elizabeth P.
Fink, Melyssa K.
Kilgard, Michael P.
TI Speech training alters consonant and vowel responses in multiple
auditory cortex fields
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Speech therapy; Auditory processing; Receptive field plasticity; Map
reorganization
ID DISCRIMINATION ABILITY; CORTICAL PLASTICITY; NEURAL RESPONSES; MAP
PLASTICITY; NOISE; REPRESENTATION; AUTISM; RAT; SOUNDS; PATTERNS
AB Speech sounds evoke unique neural activity patterns in primary auditory cortex (A1). Extensive speech sound discrimination training alters A1 responses. While the neighboring auditory cortical fields each contain information about speech sound identity, each field processes speech sounds differently. We hypothesized that while all fields would exhibit training-induced plasticity following speech training, there would be unique differences in how each field changes. In this study, rats were trained to discriminate speech sounds by consonant or vowel in quiet and in varying levels of background speech-shaped noise. Local field potential and multiunit responses were recorded from four auditory cortex fields in rats that had received 10 weeks of speech discrimination training. Our results reveal that training alters speech evoked responses in each of the auditory fields tested. The neural response to consonants was significantly stronger in anterior auditory field (AAF) and A1 following speech training. The neural response to vowels following speech training was significantly weaker in ventral auditory field (VAF) and posterior auditory field (PAF). This differential plasticity of consonant and vowel sound responses may result from the greater paired pulse depression, expanded low frequency tuning, reduced frequency selectivity, and lower tone thresholds, which occurred across the four auditory fields. These findings suggest that alterations in the distributed processing of behaviorally relevant sounds may contribute to robust speech discrimination. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Engineer, Crystal T.; Rahebi, Kimiya C.; Buell, Elizabeth P.; Fink, Melyssa K.; Kilgard, Michael P.] Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75080 USA.
RP Engineer, CT (reprint author), Univ Texas Dallas, Sch Behav & Brain Sci, 800 West Campbell Rd,GR41, Richardson, TX 75080 USA.
EM novitski@utdallas.edu
FU National Institutes of Health [R01DC010433]
FX We would like to thank Michael Borland and Linda Wilson for assistance
with auditory cortex recordings, and Bogdan Bordieanu for assistance
with speech training sessions. This research was supported by a grant
from the National Institutes of Health to MPK (Grant # R01DC010433).
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NR 54
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUL 1
PY 2015
VL 287
BP 256
EP 264
DI 10.1016/j.bbr.2015.03.044
PG 9
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CI8QV
UT WOS:000355037700033
PM 25827927
ER
PT J
AU Kratz, HE
Locke, J
Piotrowski, Z
Ouellette, RR
Xie, M
Stahmer, AC
Mandell, DS
AF Kratz, Hilary E.
Locke, Jill
Piotrowski, Zinnia
Ouellette, Rachel R.
Xie, Ming
Stahmer, Aubyn C.
Mandell, David S.
TI All Together Now: Measuring Staff Cohesion in Special Education
Classrooms
SO JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
LA English
DT Article
DE autism; classroom cohesion; teacher-staff relationship; classroom team
ID EMPIRICAL-EXAMINATION; AUTISM INTERVENTION; INNOVATION; TEAMS; SPORT
AB This study sought to validate a new measure, the Classroom Cohesion Survey (CCS), designed to examine the relationship between teachers and classroom assistants in autism support classrooms. Teachers, classroom assistants, and external observers showed good inter-rater agreement on the CCS and good internal consistency for all scales. Simple factor structures were found for both teacher- and classroom assistant-rated scales, with one-factor solutions for both scales. Paired t tests revealed that on average, classroom assistants rated classroom cohesion stronger than teachers. The CCS may be an effective tool for measuring cohesion between classroom staff and may have an important impact on various clinical and implementation outcomes in school settings.
C1 [Kratz, Hilary E.; Locke, Jill; Piotrowski, Zinnia; Ouellette, Rachel R.; Xie, Ming; Mandell, David S.] Univ Penn, Philadelphia, PA 19104 USA.
[Stahmer, Aubyn C.] Rady Childrens Hosp, San Diego, CA USA.
[Stahmer, Aubyn C.] Univ Calif San Diego, San Diego, CA 92103 USA.
RP Kratz, HE (reprint author), Univ Penn, 3535 Market St,Suite 600, Philadelphia, PA 19104 USA.
EM dingfeld@mail.med.upenn.edu
FU NIMH [1R01MH083717-01A1, F31-MH088172]; IES [R324A08195]; FARFund;
Autism Science Foundation Early Career Award
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This study
was drawn from the Philadelphia Autism Instructional Methods Study,
which was supported by NIMH Grant 1R01MH083717-01A1 and IES Grant
R324A08195. This study was also funded by the NIMH F31-MH088172 grant
awarded to the first author and the FARFund and the Autism Science
Foundation Early Career Award granted to the second author.
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NR 22
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0734-2829
EI 1557-5144
J9 J PSYCHOEDUC ASSESS
JI J. Psychoeduc. Assess.
PD JUL
PY 2015
VL 33
IS 4
BP 329
EP 338
DI 10.1177/0734282914554853
PG 10
WC Psychology, Educational
SC Psychology
GA CJ1SS
UT WOS:000355265400003
ER
PT J
AU Robertson, RE
AF Robertson, Rachel E.
TI The Acquisition of Problem Behavior in Individuals With Developmental
Disabilities as a Behavioral Cusp
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE behavioral cusp; problem behavior; developmental disabilities
ID SELF-INJURIOUS-BEHAVIOR; AUTISM SPECTRUM DISORDERS; CHALLENGING
BEHAVIORS; INTELLECTUAL DISABILITY; DESCRIPTIVE ANALYSIS; STAFF
BEHAVIOR; YOUNG-CHILDREN; PEOPLE; REINFORCEMENT; CLASSROOMS
AB A behavioral cusp has been defined as a behavior change that produces contact with new contingencies with important and far-reaching consequences. The concept of behavioral cusps has most frequently been used to select target skills taught to learners and to evaluate the importance of those skills; however, the concept is equally applicable to behavior changes that bring about important and far-reaching negative consequences. Although it has been acknowledged that socially undesirable behavior change can also qualify as a behavioral cusp, this area of the cusp concept has been under-examined. In this article, an undesirable behavior change, the acquisition of problem behavior in individuals with developmental disabilities, is compared with criteria for behavioral cusps previously identified in the literature. The advantages of viewing problem behavior as a behavioral cusp are outlined, and implications for practice and research from a behavioral cusp approach to problem behavior are provided.
C1 [Robertson, Rachel E.] Univ Pittsburgh, Special Educ, Pittsburgh, PA 15260 USA.
RP Robertson, RE (reprint author), Univ Pittsburgh, Dept Instruct & Learning, 5146 WWPH,230 S Bouquet St, Pittsburgh, PA 15260 USA.
EM rachelr@pitt.edu
FU Office of Special Education Programs Leadership Training Grants
[H325D020022, H325D070083]
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article:
Preparation of this manuscript was funded in part by the Office of
Special Education Programs Leadership Training Grants (H325D020022;
H325D070083). The opinions expressed in this article are those of the
author and do not necessarily reflect those of the funding agency.
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NR 53
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
EI 1552-4167
J9 BEHAV MODIF
JI Behav. Modificat.
PD JUL
PY 2015
VL 39
IS 4
BP 475
EP 495
DI 10.1177/0145445515572185
PG 21
WC Psychology, Clinical
SC Psychology
GA CI8BQ
UT WOS:000354992900001
PM 25733661
ER
PT J
AU Scalzo, R
Henry, K
Davis, TN
Amos, K
Zoch, T
Turchan, S
Wagner, T
AF Scalzo, Rachel
Henry, Kelsey
Davis, Tonya N.
Amos, Kally
Zoch, Tamara
Turchan, Sarah
Wagner, Tara
TI Evaluation of Interventions to Reduce Multiply Controlled Vocal
Stereotypy
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE vocal stereotypy; autism; functional communication training
ID DEVELOPMENTAL-DISABILITIES; INAPPROPRIATE VOCALIZATIONS; AUTOMATIC
REINFORCEMENT; MATCHED STIMULATION; ABERRANT BEHAVIOR; AUTISM; CHILDREN;
INDIVIDUALS; IMMEDIATE
AB This study examined four interventions targeted at decreasing multiply controlled vocal stereotypy for a 12-year-old boy diagnosed with autism spectrum disorder and a severe intellectual disability. These interventions included Noncontingent Music, Differential Reinforcement of Other Behaviors, Self-Recording, and Functional Communication Training (FCT). In addition to measuring vocal stereotypy during each condition, task engagement and challenging behavior were also monitored. Across conditions, vocal stereotypy did not vary significantly from baseline except in FCT, when it decreased significantly. Task engagement was higher in this condition as well. It is hypothesized that FCT provided an enriched environment by increasing social interaction and access to desired items as well as removal of less preferred activities. For these reasons, there was a decrease in the need for the participant to engage in vocal stereotypy and challenging behavior and increase in his ability to engage in a task.
C1 [Scalzo, Rachel] Baylor Univ, Educ Psychol Specializing Appl Behav Anal, Waco, TX 76798 USA.
[Henry, Kelsey] Baylor Univ, Sch Psychol, Waco, TX 76798 USA.
[Davis, Tonya N.] Baylor Univ, Dept Educ Psychol, Waco, TX 76798 USA.
[Scalzo, Rachel; Amos, Kally; Zoch, Tamara; Turchan, Sarah; Wagner, Tara] Baylor Univ, Waco, TX 76798 USA.
RP Scalzo, R (reprint author), Baylor Univ, One Bear Pl 97031, Waco, TX 76798 USA.
EM Rachel_Scalzo@Baylor.edu
CR Ahearn WH, 2003, J APPL BEHAV ANAL, V36, P439, DOI 10.1901/jaba.2003.36-439
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American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 24
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
EI 1552-4167
J9 BEHAV MODIF
JI Behav. Modificat.
PD JUL
PY 2015
VL 39
IS 4
BP 496
EP 509
DI 10.1177/0145445515573986
PG 14
WC Psychology, Clinical
SC Psychology
GA CI8BQ
UT WOS:000354992900002
PM 25733663
ER
PT J
AU Allen, KD
Vatland, C
Bowen, SL
Burke, RV
AF Allen, Keith D.
Vatland, Christopher
Bowen, Scott L.
Burke, Raymond V.
TI An Evaluation of Parent-Produced Video Self-Modeling to Improve
Independence in an Adolescent With Intellectual Developmental Disorder
and an Autism Spectrum Disorder: A Controlled Case Study
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE video modeling; community living; transition; parents; autism;
intellectual disability
ID INTERVENTIONS; DISABILITY; CHILDREN
AB We evaluated a parent-created video self-modeling (VSM) intervention to improve independence in an adolescent diagnosed with Intellectual Developmental Disorder (IDD) and Autism Spectrum Disorder (ASD). In a multiple baseline design across routines, a parent and her 17-year-old daughter created self-modeling videos of three targeted routines needed for independence in the community. The parent used a tablet device with a mobile app called VideoTote to produce videos of the daughter performing the targeted routines. The mobile app includes a 30-s tutorial about making modeling videos. The parent and daughter produced and watched a VSM scene prior to performing each of the three routines in an analogue community setting. The adolescent showed marked, immediate, and sustained improvements in performing each routine following the production and implementation of the VSM. Performance was found to generalize to the natural community setting. Results suggest that parents can use available technology to promote community independence for transition age individuals.
C1 [Allen, Keith D.] Munroe Meyer Inst Genet & Rehabil, Omaha, NE USA.
[Vatland, Christopher] Univ S Florida, Dept Child & Family Studies, Tampa, FL USA.
[Bowen, Scott L.; Burke, Raymond V.] Prevent Grp, Omaha, NE USA.
RP Allen, KD (reprint author), Munroe Meyer Inst, 985450 Nebraska Med Ctr, Omaha, NE 68198 USA.
EM kdallen@unmc.edu
FU Autism Action Partnership, Omaha, Nebraska; Maternal and Child Bureau,
Health Resources and Services Administration [T73MC00023];
Administration on Intellectual and Developmental Disabilities,
Department of Health and Human Services [90DD0701]
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This
project was made possible in large part by the generous support of the
Autism Action Partnership, Omaha, Nebraska. Support was also provided by
Grant T73MC00023 from the Maternal and Child Bureau, Health Resources
and Services Administration, and by Grant 90DD0701 from the
Administration on Intellectual and Developmental Disabilities,
Department of Health and Human Services.
CR [Anonymous], 2009, NAT STAND PROJ ADDR
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NR 23
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
EI 1552-4167
J9 BEHAV MODIF
JI Behav. Modificat.
PD JUL
PY 2015
VL 39
IS 4
BP 542
EP 556
DI 10.1177/0145445515583247
PG 15
WC Psychology, Clinical
SC Psychology
GA CI8BQ
UT WOS:000354992900004
PM 25903581
ER
PT J
AU Kocher, CP
Howard, MR
Fienup, DM
AF Kocher, Colleen P.
Howard, Monica R.
Fienup, Daniel M.
TI The Effects of Work-Reinforcer Schedules on Skill Acquisition for
Children With Autism
SO BEHAVIOR MODIFICATION
LA English
DT Article
DE work-reinforcer schedules; preference; skill acquisition; autism;
reinforcement
ID PREFERENCE
AB This study evaluated the effects of continuous and discontinuous work-reinforcer schedule arrangements on skill acquisition for three students with autism. Participants were initially exposed to both schedules in an alternating schedules condition where they were taught different but equivalent skills for each schedule. In the discontinuous schedule condition, participants completed work in small increments to gain access to a reinforcer for short periods of time. In the continuous schedule condition, participants completed larger increments of work to gain longer access to a reinforcer. Results showed that two participants mastered the target responses with both schedules and the third participant only met mastery criterion with the continuous schedule. Preference for schedules varied across participants. Session duration was consistently shorter during the continuous work-reinforcer schedule, suggesting that continuous work-reinforcer schedules are more efficient. Participants engaged with the reinforcer less when provided longer access, suggesting that reinforcer access might be reduced with continuous schedules for further efficiency gains.
C1 [Kocher, Colleen P.; Howard, Monica R.] ELIJA Sch, Levittown, NY USA.
[Kocher, Colleen P.; Fienup, Daniel M.] CUNY Queens Coll, Flushing, NY 11367 USA.
RP Fienup, DM (reprint author), CUNY Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA.
EM daniel.fienup@qc.cuny.edu
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NR 9
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-4455
EI 1552-4167
J9 BEHAV MODIF
JI Behav. Modificat.
PD JUL
PY 2015
VL 39
IS 4
BP 600
EP 621
DI 10.1177/0145445515583246
PG 22
WC Psychology, Clinical
SC Psychology
GA CI8BQ
UT WOS:000354992900007
PM 25896361
ER
PT J
AU Chen, N
Koopmans, F
Gordon, A
Paliukhovich, I
Klaassen, RV
van der Schors, RC
Peles, E
Verhage, M
Smit, AB
Li, KW
AF Chen, Ning
Koopmans, Frank
Gordon, Aaron
Paliukhovich, Iryna
Klaassen, Remco V.
van der Schors, Roe C.
Peles, Elior
Verhage, Matthijs
Smit, August B.
Li, Ka Wan
TI Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the
presence of two Caspr2 isoforms with overlapping interactomes
SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
LA English
DT Article
DE Autism; Caspr2; Interaction proteomics; Mouse model; Brain
ID AUTISM SPECTRUM DISORDERS; MYELINATED AXONS; PROTEIN; CHANNELS; REGIONS;
TWIN
AB Autism is a human developmental brain disorder characterized by impaired social interaction and communication. Contactin-associated protein-like 2 (Caspr2, CNTNAP2) is a known genetic risk factor of autism. However, how this protein might contribute to pathology is unclear. In this study, we demonstrate that Caspr2 is abundantly present in lipid raft and in the synaptic membrane but is highly depleted in the postsynaptic density. The Caspr2 protein level in hippocampus is present at a constant level during synapse formation and myelination from PO to P84. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs). Interestingly, a short form of Caspr2 was detected, which lacks most of the extracellular domains, however, is still associated with ADAM22 and to a lesser extent LGI1 and Kv1 channels. The comprehensive Caspr2 interactome revealed here might aid in understanding the molecular mechanisms underlying autism. This article is part of a Special Issue titled Neuroproteomics: Applications in Neuroscience and Neurology. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Chen, Ning; Paliukhovich, Iryna; Klaassen, Remco V.; van der Schors, Roe C.; Smit, August B.; Li, Ka Wan] Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Mol & Cellular Neurobiol, NL-1081 HV Amsterdam, Netherlands.
[Chen, Ning; Koopmans, Frank; Verhage, Matthijs] Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Funct Genom, NL-1081 HV Amsterdam, Netherlands.
[Gordon, Aaron; Peles, Elior] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel.
RP Li, KW (reprint author), Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Mol & Cellular Neurobiol, Neurosci Campus Amsterdam,Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands.
EM k.w.li@vu.nl
FU Netherlands Institute for Systems Biology (NISB (NWO-ALW)); NIH
[NS50220]; Israel Science Foundation; Netherlands Organization for
Scientific Research (NWO) Complexity project [645.000.003]; EU-FP7
'SynSys' [HEALTH-2009-2.1.2-1, 242167]
FX Ning Chen was funded by a grant from the Netherlands Institute for
Systems Biology (NISB (NWO-ALW)). Aaron Gordon and Elior Peles received
support from the NIH (NS50220 to EP) and the Israel Science Foundation.
Ka Wan Li, Roel C. van der Schors and August B. Smit received support
from HEALTH-2009-2.1.2-1 EU-FP7 'SynSys' (#242167). Frank Koopmans was
funded from the Netherlands Organization for Scientific Research (NWO)
Complexity project 645.000.003.
CR Anderson GM, 2012, J AUTISM DEV DISORD, V42, P1526, DOI 10.1007/s10803-012-1552-6
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Association A.P., 2013, DIAGN STAT MAN MENT
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NR 21
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1570-9639
EI 0006-3002
J9 BBA-PROTEINS PROTEOM
JI BBA-Proteins Proteomics
PD JUL
PY 2015
VL 1854
IS 7
SI SI
BP 827
EP 833
DI 10.1016/j.bbapap.2015.02.008
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA CI8QJ
UT WOS:000355036500013
PM 25707359
ER
PT J
AU Yepsen, O
Contreras, D
Santander, P
Yanez, J
Mansilla, HD
Amarasiriwardena, D
AF Yepsen, Orlando
Contreras, David
Santander, Paola
Yanez, Jorge
Mansilla, Hector D.
Amarasiriwardena, Dulasiri
TI Photocatalytic degradation of thimerosal in human vaccine's residues and
mercury speciation of degradation by-products
SO MICROCHEMICAL JOURNAL
LA English
DT Article
DE Thimerosal degradation; Vaccines; Mercury; Heterogeneous photocatalysis;
TiO2; Mercury speciation; Mercury vapor
ID ADVANCED OXIDATION PROCESSES; WASTE-WATER TREATMENT; NEURODEVELOPMENTAL
DISORDERS; AUTISM; EXPOSURE; PHARMACEUTICALS; IDENTIFICATION;
METHYLMERCURY; ETHYLMERCURY
AB Thimerosal (sodium ethylmercury thiosalicylate) has been intensively used as a stabilizer of pharmaceuticals, mainly in human and veterinary vaccines. Yearly loss of thousands of vaccines occurs due to expiration, loss of cold chain and overstock; therefore safe disposal of expired vaccines containing thimerosal has become high priority. In this work, UVA light assisted TiO2 heterogeneous photocatalysis has been applied for the first time in order to degrade thimerosal contained in hepatitis B vaccine residues (HibTITER). The photocatalytic process was optimized using the Response Surface Methodology (RSM). Most favorable experimental conditions to achieve the maximum degradation of thimerosal were pH 2 and 0.2 g L-1 TiO2 under nitrogen bubbling. Under these conditions thimerosal contained in vaccine residues was completely degraded within 20 min by UV-A assisted photocatalysis. The mercury in thimerosal was reduced to elemental mercury and removed from the solution in vapor form. The organic groups of thimerosal were oxidized to thiosalicylic acid, salicylic acid and dithiosalicylic acid, identified as by-products. The degradation pathway of thimerosal by photocatalysis and photolysis is proposed. This photocatalytic procedure is environmentally friendly and it could be considered as promising treatment approach for hazardous organomercurial compounds. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Yepsen, Orlando; Contreras, David; Santander, Paola; Yanez, Jorge] Univ Concepcion, Fac Chem Sci, Dept Analyt & Inorgan Chem, Concepcion, Chile.
[Mansilla, Hector D.] Univ Concepcion, Fac Chem Sci, Dept Organ Chem, Concepcion, Chile.
[Amarasiriwardena, Dulasiri] Hampshire Coll, Sch Nat Sci, Amherst, MA 01002 USA.
RP Yanez, J (reprint author), Univ Concepcion, Fac Chem Sci, Edmundo Larenas 129, Concepcion, Chile.
EM jyanez@udec.cl; hmansill@udec.cl
FU National Commission for Scientific and Technological Research (Conicyt)
project Fondecyt [1121128, 1130502]; National Commission for Scientific
and Technological Research (Conicyt) project Conicyt/FONDAP [15110019];
Red Doctoral REDOC.CTA; MINEDUC [UCO1202]; international collaboration
program of project Fondecyt [1121128]
FX The authors thank the support of the National Commission for Scientific
and Technological Research (Conicyt) projects Fondecyt nos. 1121128 and
1130502, and Conicyt/FONDAP 15110019. Furthermore, the authors
appreciate the support of Red Doctoral REDOC.CTA, MINEDUC project
UCO1202 at the University of Concepcion and the international
collaboration program of project Fondecyt no. 1121128 for the financial
support of Professor Dulasiri Amarasiriwardena visit to the University
of Concepcion.
CR [Anonymous], 2010, PRES DISP GUID 2010
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NR 41
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0026-265X
EI 1095-9149
J9 MICROCHEM J
JI Microchem J.
PD JUL
PY 2015
VL 121
BP 41
EP 47
DI 10.1016/j.microc.2015.02.001
PG 7
WC Chemistry, Analytical
SC Chemistry
GA CI2PO
UT WOS:000354589700007
ER
PT J
AU Khosrowabadi, R
Quek, C
Ang, KK
Wahab, A
Chen, SHA
AF Khosrowabadi, Reza
Quek, Chai
Ang, Kai Keng
Wahab, Abdul
Chen, Shen-Hsing Annabel
TI Dynamic screening of autistic children in various mental states using
pattern of connectivity between brain regions
SO APPLIED SOFT COMPUTING
LA English
DT Article
DE Autism screening; EEG; Connectivity feature; Affective face perception;
Pattern recognition
ID EEG PHASE RESET; SPECTRUM DISORDER; FUNCTIONAL CONNECTIVITY; TYPICAL
DEVELOPMENT; CORPUS-CALLOSUM; FACE; RECOGNITION; EMOTION; NETWORK;
UNDERCONNECTIVITY
AB In this study, a dynamic screening strategy is proposed to discriminate subjects with autistic spectrum disorder (ASD) from healthy controls. The ASD is defined as a neurodevelopmental disorder that disrupts normal patterns of connectivity between the brain regions. Therefore, the potential use of such abnormality for autism screening is investigated. The connectivity patterns are estimated from electroencephalogram (EEG) data collected from 8 brain regions under various mental states. The EEG data of 12 healthy controls and 6 autistic children (age matched in 7-10) were collected during eyes-open and eyes-close resting states as well as when subjects were exposed to affective faces (happy, sad and calm). Subsequently, the subjects were classified as autistic or healthy groups based on their brain connectivity patterns using pattern recognition techniques. Performance of the proposed system in each mental state is separately evaluated. The results present higher recognition rates using functional connectivity features when compared against other existing feature extraction methods. (C) 2015 Published by Elsevier B.V.
C1 [Khosrowabadi, Reza; Quek, Chai] Nanyang Technol Univ, Sch Comp Engn, Singapore 639798, Singapore.
[Khosrowabadi, Reza] Shahid Beheshti Univ, Inst Cognit & Brain Sci, Tehran 1983963113, Iran.
[Ang, Kai Keng] Agcy Sci Technol & Res, Inst Infocomm Res, Singapore 138632, Singapore.
[Wahab, Abdul] Int Islamic Univ, Sch Informat & Commun Technol, Kuala Lumpur 50728, Malaysia.
[Chen, Shen-Hsing Annabel] Nanyang Technol Univ, Sch Humanities & Social Sci, Singapore 637332, Singapore.
[Chen, Shen-Hsing Annabel] Nanyang Technol Univ, Ctr Res & Dev Learning CRADLE, Singapore 637459, Singapore.
RP Khosrowabadi, R (reprint author), Nanyang Technol Univ, Sch Comp Engn, Block N4 2A-32,Nanyang Ave, Singapore 639798, Singapore.
EM reza0004@e.ntu.edu.sg; ashcqueck@ntu.edu.sg; kkang@i2r.a-star.edu.sg;
abdulwahab@iium.edu.my; annabelchen@ntu.edu.sg
RI ahmed, Jamila/E-8653-2015
FU International Islamic University of Malaysia (IIUM) [EDW A-10554]
FX This project is supported by the International Islamic University of
Malaysia (IIUM) endowment fund (EDW A-10554). The authors would like to
thank Drs. Bjorn Cri its from Biometrisch centrum for sponsoring the EEG
machine, the National Autism Society of Malaysia (NASOM) for conducting
the intelligence and screening tests and coordination of EEG sessions
with ASD children, Ms. Marini Othman and Ms. Najwani Razali from IIUM
department of computer science for their support in the data collection
of the experiment and Dr. Elsbeth Huberta Peters-Gruetzmacher from
university of Malaya Centre Of Addiction Sciences (UMCAS) for her advice
on the design phase of this experiment.
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NR 82
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1568-4946
EI 1872-9681
J9 APPL SOFT COMPUT
JI Appl. Soft. Comput.
PD JUL
PY 2015
VL 32
BP 335
EP 346
DI 10.1016/j.asoc.2015.03.030
PG 12
WC Computer Science, Artificial Intelligence; Computer Science,
Interdisciplinary Applications
SC Computer Science
GA CH7AD
UT WOS:000354187000029
ER
PT J
AU Aradhye, C
Vonk, J
Arida, D
AF Aradhye, Chinmay
Vonk, Jennifer
Arida, Danielle
TI Adults' responsiveness to children's facial expressions
SO JOURNAL OF EXPERIMENTAL CHILD PSYCHOLOGY
LA English
DT Article
DE Young children's expressions; Emotion; Responsiveness; Cuteness;
Nurture; Parenting
ID EARLY INFANT COMMUNICATION; HIGH-FUNCTIONING AUTISM; SEX-DIFFERENCES;
PHYSICAL ATTRACTIVENESS; BABY SCHEMA; PARENTAL SENSITIVITY; MATERNAL
SENSITIVITY; PERSPECTIVE-TAKING; MOTHER ATTACHMENT; PREMATURE-INFANTS
AB We investigated the effect of young children's (hereafter children's) facial expressions on adult responsiveness. In Study 1, 131 undergraduate students from a midsized university in the midwestern United States rated children's images and videos with smiling, crying, or neutral expressions on cuteness, likelihood to adopt, and participants' experienced distress. Looking times at images and videos along with perception of cuteness, likelihood to adopt, and experienced distress using 10-point Likert scales were measured. Videos of smiling children were rated as cuter and more likely to be adopted and were viewed for longer times compared with videos of crying children, which evoked more distress. In Study 2, we recorded responses from 101 of the same participants in an online survey measuring gender role identity, empathy, and perspective taking. Higher levels of femininity (as measured by Bem's Sex Role Inventory) predicted higher "likely to adopt" ratings for crying images. These findings indicate that adult perception of children and motivation to nurture are affected by both children's facial expressions and adult characteristics and build on existing literature to demonstrate that children may use expressions to manipulate the motivations of even non-kin adults to direct attention toward and perhaps nurture young children. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Aradhye, Chinmay; Vonk, Jennifer; Arida, Danielle] Oakland Univ, Dept Psychol, Rochester, MI 48309 USA.
RP Aradhye, C (reprint author), Oakland Univ, Dept Psychol, Rochester, MI 48309 USA.
EM caradhye@oakland.edu
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NR 75
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-0965
EI 1096-0457
J9 J EXP CHILD PSYCHOL
JI J. Exp. Child Psychol.
PD JUL
PY 2015
VL 135
BP 56
EP 71
DI 10.1016/j.jecp.2015.02.006
PG 16
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA CH2HH
UT WOS:000353845800004
PM 25838165
ER
PT J
AU Voytek, B
Knight, RT
AF Voytek, Bradley
Knight, Robert T.
TI Dynamic Network Communication as a Unifying Neural Basis for Cognition,
Development, Aging, and Disease
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Anxiety; Autism; Coherence; Coupling; Depression; Gamma; Network
dynamics; Neural oscillations; Parkinson's disease; Schizophrenia; Theta
ID DEEP BRAIN-STIMULATION; ELECTROCORTICOGRAPHIC SPECTRAL-ANALYSIS; HUMAN
SENSORIMOTOR CORTEX; WORKING-MEMORY; FUNCTIONAL CONNECTIVITY; GAMMA
OSCILLATIONS; PREFRONTAL CORTEX; VISUAL-CORTEX; BASAL GANGLIA;
LARGE-SCALE
AB Perception, cognition, and social interaction depend upon coordinated neural activity. This coordination operates within noisy, overlapping, and distributed neural networks operating at multiple timescales. These networks are built upon a structural scaffolding with intrinsic neuroplasticity that changes with development, aging, disease, and personal experience. In this article, we begin from the perspective that successful interregional communication relies upon the transient synchronization between distinct low-frequency (<80 Hz) oscillations, allowing for brief windows of communication via phase-coordinated local neuronal spiking. From this, we construct a theoretical framework for dynamic network communication, arguing that these networks reflect a balance between oscillatory coupling and local population spiking activity and that these two levels of activity interact. We theorize that when oscillatory coupling is too strong, spike timing within the local neuronal population becomes too synchronous; when oscillatory coupling is too weak, spike timing is too disorganized. Each results in specific disruptions to neural communication. These alterations in communication dynamics may underlie cognitive changes associated with healthy development and aging, in addition to neurological and psychiatric disorders. A number of neurological and psychiatric disorders-including Parkinson's disease, autism, depression, schizophrenia, and anxiety-are associated with abnormalities in oscillatory activity. Although aging, psychiatric and neurological disease, and experience differ in the biological changes to structural gray or white matter, neurotransmission, and gene expression, our framework suggests that any resultant cognitive and behavioral changes in normal or disordered states or their treatment are a product of how these physical processes affect dynamic network communication.
C1 [Voytek, Bradley] Univ Calif San Diego, Dept Cognit Sci, Neurosci Grad Program, La Jolla, CA 92093 USA.
[Voytek, Bradley] Univ Calif San Diego, Inst Neural Computat, La Jolla, CA 92093 USA.
[Knight, Robert T.] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA.
[Knight, Robert T.] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA.
RP Voytek, B (reprint author), Univ Calif San Diego, Dept Cognit Sci, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM bradley.voytek@gmail.com
FU University of California, San Diego; Sloan Research Fellowship; National
Institute of Neurological Disorders and Stroke Grant [R37 NS21135-27];
Defense Advanced Research Projects Agency Systems-Based Neurotechnology
for Emerging Therapies; Qualcomm Institute; California Institute for
Telecommunications and Information Technology, Strategic Research
Opportunities program
FX This work was supported by the University of California, San Diego,
Qualcomm Institute, California Institute for Telecommunications and
Information Technology, Strategic Research Opportunities program (BV)
and a Sloan Research Fellowship (BV), as well as National Institute of
Neurological Disorders and Stroke Grant R37 NS21135-27 (RTK) and Defense
Advanced Research Projects Agency Systems-Based Neurotechnology for
Emerging Therapies (RTK).
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NR 129
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JUN 15
PY 2015
VL 77
IS 12
BP 1089
EP 1097
DI 10.1016/j.biopsych.2015.04.016
PG 9
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CJ0BX
UT WOS:000355138500011
ER
PT J
AU Park, M
Baek, IJ
Kim, H
Woo, DK
Park, YJ
Shim, S
AF Park, Minsoo
Baek, In-Jeoung
Kim, Hyunduk
Woo, Dong Kyun
Park, Young-Jun
Shim, Sungbo
TI CCN3 overexpression inhibits growth of callosal projections via
upregulation of RAB25
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE CCN3; RAB25; Neurite outgrowth; Callosal projection; Cortex
ID DEVELOPING CEREBRAL-CORTEX; NEURON IDENTITY; EXPRESSION; BRAIN;
TRANSCRIPTOME; PROTEINS; SYSTEM; FAMILY; AUTISM; SIZE
AB The cysteine-rich 61/connective tissue growth factor 3 (CCN3) is a member of the CCN family of secreted multifunctional proteins involved in a variety of cellular processes including migration, adhesion, and differentiation. Previous studies have shown that CCN3 is expressed in the developing rat central nervous system, and enhanced CCN3 expression is highly correlated with tumorigenesis. However, the expression pattern and influence of abnormal CCN3 expression during mouse cortical development remains to be elucidated. Here, we show that CCN3 expression in mice is first detectable at embryonic day 15 and increases until postnatal day 21. We overexpressed CCN3 in mouse cortical neurons using uni- and bilateral electroporation. Our in vivo overexpression experiments showed that elevated CCN3 expression inhibited the axonal outgrowth of callosal projection neurons. Moreover, we identified the small GTPase RAB25 as a downstream effector molecule of CCN3 using transcriptomic analysis with CCN3 overexpressed in cortical tissue. In vivo ectopic expression of RAB25 or the dominant-negative RAB25-T26N also revealed that the GTPase activity of RAB25 is involved in the CCN3-mediated regulation of neuronal outgrowth. Taken together, our results suggest that tight regulation of CCN3 expression is necessary for normal cortical neuronal connectivity during development, and RAB25 negatively regulates neuronal differentiation as a downstream effector of CCN3. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Park, Minsoo; Kim, Hyunduk; Shim, Sungbo] Univ Ulsan Coll Med, Dept Biomed Sci, Seoul 138736, South Korea.
[Park, Young-Jun] Korea Res Inst Biosci & Biotechnol, Immunotherapy Res Ctr, Daejeon, South Korea.
[Park, Minsoo; Baek, In-Jeoung; Kim, Hyunduk; Shim, Sungbo] Neuromarker Resource Bank NRB, Seoul 138736, South Korea.
[Woo, Dong Kyun] Gyeongsang Natl Univ, Coll Pharm, Gyeongnam, South Korea.
[Woo, Dong Kyun] Gyeongsang Natl Univ, Pharmaceut Sci Res Inst, Gyeongnam, South Korea.
[Baek, In-Jeoung] Asan Inst Life Sci, Seoul 138736, South Korea.
RP Shim, S (reprint author), Univ Ulsan Coll Med, Dept Biomed Sci, Seoul 138736, South Korea.
EM pyj71@kribb.re.kr; sungbo@ulsan.ac.kr
FU Bio & Medical Technology Development Program of the National Research
Foundation (NRF) - Korean government (MSIP) [NRF-2014M3A9B8023198,
NRF-2013M3A9B6046567, NRF-2014R1A1A1003690]; Ministry of Education,
Science Technology; KRIBB Research Initiative Program, Republic of
Korea; Korean Health Technology R&D Project, Ministry of Health Welfare
[A121338]
FX This research was supported by the Bio & Medical Technology Development
Program of the National Research Foundation (NRF) funded by the Korean
government (MSIP) (NRF-2014M3A9B8023198, NRF-2013M3A9B6046567 and
NRF-2014R1A1A1003690). This study was also supported by a grant of the
Korean Health Technology R&D Project, Ministry of Health & Welfare
(A121338), and the Ministry of Education, Science & Technology, and the
KRIBB Research Initiative Program, Republic of Korea.
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NR 28
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 5
PY 2015
VL 461
IS 3
BP 456
EP 462
DI 10.1016/j.bbrc.2015.04.016
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA CJ0HU
UT WOS:000355157200004
PM 25871796
ER
PT J
AU Quintela, I
Barros, F
Lago-Leston, R
Castro-Gago, M
Carracedo, A
Eiris, J
AF Quintela, Ines
Barros, Francisco
Lago-Leston, Ramon
Castro-Gago, Manuel
Carracedo, Angel
Eiris, Jesus
TI A maternally inherited 16p13.11-p12.3 duplication concomitant with a de
novo SOX5 deletion in a male patient with global developmental delay,
disruptive and obsessive behaviors and minor dysmorphic features
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE 16p13; 11-p12; 3 duplication; 12p12; 1 deletion; SOX5; intellectual
disability; global developmental delay; disruptive behavior; obsessive
behavior; dysmorphism
ID TRANSCRIPTION FACTORS; LONG FORM; L-SOX5; HAPLOINSUFFICIENCY; DISORDERS;
VARIANTS; ACTIVATE; AUTISM; GENE; CNVS
AB We detail here the clinical description and the family genetic study of a male patient with global developmental delay, disruptive and obsessive behaviors and minor dysmorphic features and a combination of two rare genetic variants: a maternally inherited 16p13.11-p12.3 duplication and a de novo 12p12.1 deletion affecting SOX5. The 16p13.11 microduplication has been implicated in several neurodevelopmental and behavioral disorders and is characterized by variable expressivity and incomplete penetrance. The causes of this variation in phenotypic expression are not fully clear, representing a challenge in genetic diagnosis and counseling. However, several authors have proposed the two-hit model as one of the underlying mechanisms for this phenotypic heterogeneity. Our data could also support this two-hit model in which the 16p13.11-p12.3 duplication might contribute to the phenotype, not only as a single event but also in association with the SOX5 deletion. The SOX5 gene plays important roles in various developmental processes and has been associated with several neurodevelopmental disorders, mainly intellectual disability, developmental delay and language and/or speech delay as well as with behavior problems and dysmorphic features. However, many of the physical features and behavioral manifestations as well as language deficiencies present in our patient are consistent with those previously reported for SOX5 deletions. Patients carrying multiple genomic variants, as the one presented here, illustrate the difficulty in analyzing genotypes when the contribution of each variant results in overlapping phenotypes and/or, alternatively, in the modification of the clinical manifestations defined by the coexisting variant. (c) 2015 Wiley Periodicals, Inc.
C1 [Quintela, Ines; Carracedo, Angel] Univ Santiago de Compostela, Ctr Nacl Genotipado, Inst Salud Carlos III, Grp Med Xenom, Santiago De Compostela, Spain.
[Barros, Francisco; Carracedo, Angel] Fdn Publ Galega Med Xenom, SERGAS, CIBERER, Grp Med Xenom,USC, Santiago De Compostela 15707, Spain.
[Lago-Leston, Ramon] Fdn Publ Galega Med Xenom, SERGAS, Grp Med Xenom, USC, Santiago De Compostela 15707, Spain.
[Castro-Gago, Manuel; Eiris, Jesus] Hosp Clin Univ Santiago de Compostela, Dept Pediat, Unidad Neurol Pediat, Santiago De Compostela, Spain.
[Carracedo, Angel] King Abdulaziz Univ, Ctr Excellence Genom Med Res, Jeddah 21413, Saudi Arabia.
RP Barros, F (reprint author), Fdn Publ Galega Med Xenom, Hosp Clin Univ, Edif Consultas Planta 2, Santiago De Compostela 15707, Spain.
EM francisco.barros.angueira@sergas.es
CR Aza-Carmona M, 2011, HUM MOL GENET, V20, P1547, DOI 10.1093/hmg/ddr032
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NR 28
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN
PY 2015
VL 167A
IS 6
BP 1315
EP 1322
DI 10.1002/ajmg.a.36909
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA CJ1WV
UT WOS:000355276700021
PM 25847113
ER
PT J
AU Liu, Y
Zhao, DM
Dong, R
Yang, XM
Zhang, YQ
Tammimies, K
Uddin, M
Scherer, SW
Gai, ZT
AF Liu, Yi
Zhao, Dongmei
Dong, Rui
Yang, Xiaomeng
Zhang, Yanqing
Tammimies, Kristiina
Uddin, Mohammed
Scherer, Stephen W.
Gai, Zhongtao
TI De novo exon 1 deletion of AUTS2 gene in a patient with autism spectrum
disorder and developmental delay: A case report and a brief literature
review
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE autism susceptibility candidate 2; neurodevelopmental disorders; autism
spectrum disorder; developmental delay
ID COPY-NUMBER VARIATION; AUTISM-SUSCEPTIBILITY-CANDIDATE-2 AUTS2;
TRANSLOCATION BREAKPOINT; IDENTIFICATION; RISK; MUTATIONS; GENOME; BRAIN
AB Exonic deletions disrupting the autism susceptibility candidate 2 (AUTS2) gene have been demonstrated as causal variants leading to neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and developmental delay (DD). Here, we report on 830kb de novo deletion at chromosome 7q11.22 in a 4-year-old male patient with ASD and DD. This deletion disrupts the promoter region and exon 1 of AUTS2, potentially leading to complete haploinsuffiency of the gene. In addition, we discuss the clinical presentation of the de novo deletion in the light of the previous studies describing deletions of AUTS2 in NDDs. (c) 2015 Wiley Periodicals, Inc.
C1 [Liu, Yi; Dong, Rui; Yang, Xiaomeng; Gai, Zhongtao] Shandong Univ, Qilu Childrens Hosp, Pediat Res Inst, Jinan 250022, Peoples R China.
[Zhao, Dongmei; Zhang, Yanqing; Gai, Zhongtao] Shandong Univ, Qilu Childrens Hosp, Pediat Hlth Inst, Jinan 250022, Peoples R China.
[Tammimies, Kristiina; Uddin, Mohammed; Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1L7, Canada.
[Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON M5S 1A1, Canada.
[Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada.
RP Scherer, SW (reprint author), Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1L7, Canada.
EM stephen.scherer@sickkids.ca; gaizhongtao@sina.com
FU GSK-CIHR Endowed Chair in Genome Sciences
FX The authors are grateful to the patient and his family for their
contribution to the project. We would like to thank Shanghai
Biotechnology Co., Shanghai Biochip National Engineering Research Center
for technical support, as well as The Centre for Applied Genomics at the
Hospital for Sick Children and the University of Toronto McLaughlin
Centre. S.W.S. is supported by the GSK-CIHR Endowed Chair in Genome
Sciences.
CR Amarillo IE, 2014, AM J MED GENET A, V164, P958, DOI 10.1002/ajmg.a.36393
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Zhang YE, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001179
NR 27
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN
PY 2015
VL 167A
IS 6
BP 1381
EP 1385
DI 10.1002/ajmg.a.37050
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA CJ1WV
UT WOS:000355276700032
PM 25851617
ER
PT J
AU Kamien, B
Harraway, J
Lundie, B
Smallhorne, L
Gibbs, V
Heath, A
Fullerton, JM
AF Kamien, Benjamin
Harraway, James
Lundie, Ben
Smallhorne, Lex
Gibbs, Vicki
Heath, Anna
Fullerton, Janice M.
TI Characterization of a 520kb deletion on chromosome 15q26.1 including
ST8SIA2 in a patient with behavioral disturbance, autism spectrum
disorder, and epilepsy: Additional information
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
C1 [Kamien, Benjamin] Hunter Genet, Newcastle, NSW 2298, Australia.
[Kamien, Benjamin] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW 2300, Australia.
[Harraway, James; Lundie, Ben; Smallhorne, Lex] Sullivan Nicolaides Pathol, Brisbane, Qld, Australia.
[Gibbs, Vicki] Autism Spectrum Australia, Sydney, NSW, Australia.
[Heath, Anna; Fullerton, Janice M.] Neurosci Res Australia, Sydney, NSW, Australia.
[Fullerton, Janice M.] Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia.
RP Kamien, B (reprint author), Hunter Genet, POB 84 Waratah, Newcastle, NSW 2298, Australia.
EM benkamien@yahoo.com.au
CR Kamien B, 2014, AM J MED GENET A, V164, P782, DOI 10.1002/ajmg.a.36345
NR 1
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN
PY 2015
VL 167A
IS 6
BP 1424
EP 1424
DI 10.1002/ajmg.a.36846
PG 1
WC Genetics & Heredity
SC Genetics & Heredity
GA CJ1WV
UT WOS:000355276700043
PM 25846131
ER
PT J
AU Le Couteur, AS
Singh, MK
Sharma, AN
AF Le Couteur, A. S.
Singh, M. K.
Sharma, A. N.
TI Understanding adolescent bipolar disorder (BD-A): when is a dual
diagnosis of autism spectrum disorder (ASD) appropriate? Experiences
from the USA and UK
SO BIPOLAR DISORDERS
LA English
DT Meeting Abstract
C1 [Le Couteur, A. S.; Sharma, A. N.] Newcastle Univ, Acad Child & Adolescent Mental Hlth, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Singh, M. K.] Stanford Univ, Pediat Bipolar Disorders Program, Stanford, CA 94305 USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD JUN
PY 2015
VL 17
SU 1
SI SI
BP 117
EP 117
PG 1
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CJ2TS
UT WOS:000355338100328
ER
PT J
AU Lambert-Brown, BL
McDonald, NM
Mattson, WI
Martin, KB
Ibanez, LV
Stone, WL
Messinger, DS
AF Lambert-Brown, Brittany L.
McDonald, Nicole M.
Mattson, Whitney I.
Martin, Katherine B.
Ibanez, Lisa V.
Stone, Wendy L.
Messinger, Daniel S.
TI Positive Emotional Engagement and Autism Risk
SO DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
DE smiling; affective communication; autism risk; infancy
ID SIBLINGS RESEARCH CONSORTIUM; UNAFFECTED SIBLINGS; SPECTRUM DISORDERS;
INFANT INTERACTION; STILL-FACE; CHILDREN; MOTHER; RESPONSIVENESS;
COMMUNICATION; ATTENTION
AB Positive emotional engagement develops in the context of face-to-face interactions during the first 6 months of life. Deficits in emotional engagement are characteristic of autism spectrum disorder (ASD) and may characterize the younger siblings of children with ASD (high-risk siblings). High-risk siblings are likely to exhibit a broad range of positive emotional engagement that may or may not be associated with ASD outcomes. We examined positive emotional engagement (i.e., smiling rate and contingent responsiveness to the partner's smile) during the infant-parent interaction episodes of the face-to-face/still face protocol at 6 months of age. The sample included 43 high-risk infant siblings, 11 of whom went on to an ASD diagnosis, and 25 low-risk siblings with no family history of ASD. Low-risk siblings and high-risk siblings without ASD showed the typical still-face effect (i.e., decreases in smiling rate after period of parental nonresponsiveness), but high-risk siblings with later ASD outcomes did not show this decrease. Although high-risk siblings without an ASD diagnosis were less likely to respond to their parents' smiles than were low-risk siblings, the children with eventual ASD did not differ from the other groups in contingent responsiveness. Findings suggest that subtle differences in positive emotional engagement are present in the early development of high-risk siblings but are not consistently associated with ASD outcomes.
C1 [Lambert-Brown, Brittany L.; McDonald, Nicole M.; Mattson, Whitney I.; Martin, Katherine B.; Messinger, Daniel S.] Univ Miami, Dept Psychol, Coral Gables, FL 33146 USA.
[Ibanez, Lisa V.; Stone, Wendy L.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
[Messinger, Daniel S.] Univ Miami, Dept Pediat, Coral Gables, FL 33146 USA.
[Messinger, Daniel S.] Univ Miami, Dept Elect & Comp Engn, Coral Gables, FL 33146 USA.
[Messinger, Daniel S.] Univ Miami, Dept Mus Engn, Coral Gables, FL 33146 USA.
RP Messinger, DS (reprint author), Univ Miami, Dept Psychol, 5665 Ponce Leon, Coral Gables, FL 33146 USA.
EM dmessinger@miami.edu
FU National Institute of Child Health and Development [R01HD057284,
R01HD047417]; National Institute of General Medical Sciences
[R01GM105004]; National Science Foundation [1052736]
FX The research reported in this article was supported by the National
Institute of Child Health and Development (Grants R01HD057284 and
R01HD047417), the National Institute of General Medical Sciences (Grant
R01GM105004), and the National Science Foundation (Grant 1052736). We
thank the families who participated in this research.
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NR 42
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0012-1649
EI 1939-0599
J9 DEV PSYCHOL
JI Dev. Psychol.
PD JUN
PY 2015
VL 51
IS 6
BP 848
EP 855
DI 10.1037/a0039182
PG 8
WC Psychology, Developmental
SC Psychology
GA CJ0MA
UT WOS:000355169100011
PM 25938555
ER
PT J
AU Fejzo, MS
Magtira, A
Schoenberg, FP
Macgibbon, K
Mullin, PM
AF Fejzo, Marlena S.
Magtira, Aromalyn
Schoenberg, Frederic Paik
Macgibbon, Kimber
Mullin, Patrick M.
TI Neurodevelopmental delay in children exposed in utero to hyperemesis
gravidarum
SO EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
LA English
DT Article
DE Hyperemesis gravidarum; Outcome; Nausea; Pregnancy; Attention, learning,
sensory, speech; Neurodevelopmental delay
ID PREGNANCY OUTCOMES; PRENATAL EXPOSURE; INCREASED RISK; DEFICIENCY;
DISEASE; HEALTH; NAUSEA; WOMEN; CONSEQUENCES; SENSITIVITY
AB Objective: The purpose of this study is to determine the frequency of emotional, behavioral, and learning disorders in children exposed in utero to hyperemesis gravidarum (HG) and to identify prognostic factors for these disorders.
Study design: Neurodevelopmental outcomes of 312 children from 203 mothers with HG were compared to neurodevelopmental outcomes from 169 children from 89 unaffected mothers. Then the clinical profiles of patients with HG and a normal child outcome were compared to the clinical profiles of patients with HG and a child with neurodevelopmental delay to identify prognostic factors. Binary responses were analyzed using either a Chi-square or Fisher Exact test and continuous responses were analyzed using a t-test.
Results: Children exposed in utero to HG have a 3.28-fold increase in odds of a neurodevelopmental diagnosis including attention disorders, learning delay, sensory disorders, and speech and language delay (P < 0.0005). Among characteristics of HG pregnancies, only early onset of symptoms (prior to 5 weeks gestation) was significantly linked to neurodevelopmental delay. We found no evidence for increased risk of 13 emotional, behavioral, and learning disorders, including autism, intellectual impairment, and obsessive-compulsive disorder. However, the study was not sufficiently powered to detect rare conditions. Medications, treatments, and preterm birth were not associated with an increased risk for neurodevelopmental delay.
Conclusion: Women with HG are at a significantly increased risk of having a child with neurodevelopmental delay. Common antiemetic treatments were not linked to neurodevelopmental delay, but early symptoms may play a role. There is an urgent need to address whether aggressive treatment that includes vitamin and nutrient supplementation in women with early symptoms of severe nausea of pregnancy decreases the risk of neurodevelopmental delay. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Fejzo, Marlena S.] Univ Calif Los Angeles, Dept Obstet Gynecol & Med, Los Angeles, CA USA.
[Magtira, Aromalyn; Schoenberg, Frederic Paik] Univ Calif Los Angeles, Dept Stat, Los Angeles, CA USA.
[Macgibbon, Kimber] Hyperemesis Educ & Res Fdn, Leesburg, VA USA.
[Fejzo, Marlena S.; Mullin, Patrick M.] Univ So Calif, Keck Sch Med, Dept Maternal Fetal Med, Los Angeles, CA 90033 USA.
RP Fejzo, MS (reprint author), 675 Charles E Young Dr S, Los Angeles, CA USA.
EM mfejzo@mednet.ucla.edu
FU Hyperemesis Education and Research Foundation
FX We are grateful to our students, Arteen Pirverdian and Erina Szeto for
their work on this project. This research was funded, in part, by the
Hyperemesis Education and Research Foundation (helpher.org).
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NR 40
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-2115
EI 1872-7654
J9 EUR J OBSTET GYN R B
JI Eur. J. Obstet. Gynecol. Reprod. Biol.
PD JUN
PY 2015
VL 189
BP 79
EP 84
DI 10.1016/j.ejogrb.2015.03.028
PG 6
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA CJ3CA
UT WOS:000355359800015
PM 25898368
ER
PT J
AU Hadad, BS
Ziv, Y
AF Hadad, Bat-Sheva
Ziv, Yair
TI Strong Bias Towards Analytic Perception in ASD Does not Necessarily Come
at the Price of Impaired Integration Skills
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Global-local processing; Weak central coherence (WCC); Enhanced
perceptual functioning (EPF); ASD; Holistic-analytic processing; Contour
integration
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM; SUPERIOR
VISUAL-SEARCH; WEAK CENTRAL COHERENCE; CONTOUR INTEGRATION; SPATIAL
PROXIMITY; ASPERGER SYNDROME; ENHANCED DISCRIMINATION; GLOBAL
INTERFERENCE; SELECTIVE ATTENTION
AB We first demonstrated analytic processing in ASD under conditions in which integral processing seems mandatory in TD observers, a pattern that is often taken to indicate a local default processing in ASD. However, this processing bias does not inevitably come at the price of impaired integration skills. Indeed, examining the same group of individuals with ASD on a task with explicit demands for integrated representations, Experiment 2 showed that the same observers with ASD demonstrated intact spatial integration. The results further showed that performance was not only quantitatively, but also qualitatively comparable to that of TD observers, demonstrating the sensitivity of integration in ASD to the same interactive effects of Gestalt cues.
C1 [Hadad, Bat-Sheva] Univ Haifa, Fac Educ, Edmond J Safra Brain Res Ctr, Dept Special Educ, IL-31905 Haifa, Israel.
[Ziv, Yair] Univ Haifa, Fac Educ, Dept Counseling & Human Dev, IL-31905 Haifa, Israel.
RP Hadad, BS (reprint author), Univ Haifa, Fac Educ, Edmond J Safra Brain Res Ctr, Dept Special Educ, IL-31905 Haifa, Israel.
EM bhadad@univ.haifa.ac.il
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NR 81
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1499
EP 1512
DI 10.1007/s10803-014-2293-5
PG 14
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700001
PM 25518823
ER
PT J
AU Whalon, KJ
Conroy, MA
Martinez, JR
Werch, BL
AF Whalon, Kelly J.
Conroy, Maureen A.
Martinez, Jose R.
Werch, Brittany L.
TI School-Based Peer-Related Social Competence Interventions for Children
with Autism Spectrum Disorder: A Meta-Analysis and Descriptive Review of
Single Case Research Design Studies
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Social competence; Social communication; Autism spectrum disorder;
Literature review; Meta-analysis
ID YOUNG-CHILDREN; COMMUNICATION-SKILLS; PRESCHOOL-CHILDREN;
ASPERGER-SYNDROME; STORIES; BEHAVIOR; INITIATIONS; INCREASE; SETTINGS;
DISABILITIES
AB The purpose of this review was to critically examine and summarize the impact of school-based interventions designed to facilitate the peer-related social competence of children with autism spectrum disorder (ASD). Reviewed studies employed a single-case experimental design, targeted peer-related social competence, included children 3-12 years old with an ASD, and took place in school settings. Articles were analyzed descriptively and using the evaluative method to determine study quality. Additionally, effect size estimates were calculated using nonoverlap of all pairs method and Tau-U. A total of 37 studies including 105 children were reviewed. Overall, ES estimates ranged from weak to strong, but on average, the reviewed interventions produced a moderate to strong effect, and quality ratings were generally in the acceptable to high range. Findings suggest that children with ASD can benefit from social skill interventions implemented with peers in school settings.
C1 [Whalon, Kelly J.] Florida State Univ, Coll Educ, Tallahassee, FL 32306 USA.
[Conroy, Maureen A.; Martinez, Jose R.; Werch, Brittany L.] Univ Florida, Coll Educ, Tallahassee, FL USA.
RP Whalon, KJ (reprint author), Florida State Univ, Coll Educ, 1114 W Call St,POB 3064450, Tallahassee, FL 32306 USA.
EM kwhalon@fsu.edu; mconroy@coe.ufl.edu; j.martinez36@gmail.com;
blwerch@gmail.com
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NR 94
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1513
EP 1531
DI 10.1007/s10803-015-2373-1
PG 19
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700002
PM 25641004
ER
PT J
AU Dekker, LP
van der Vegt, EJM
Visser, K
Tick, N
Boudesteijn, F
Verhulst, FC
Maras, A
Greaves-Lord, K
AF Dekker, Linda P.
van der Vegt, Esther J. M.
Visser, Kirsten
Tick, Nouchka
Boudesteijn, Frieda
Verhulst, Frank C.
Maras, Athanasios
Greaves-Lord, Kirstin
TI Improving Psychosexual Knowledge in Adolescents with Autism Spectrum
Disorder: Pilot of the Tackling Teenage Training Program
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Psychosexual functioning; Autism spectrum disorder; Psychosexual
knowledge; Training program
ID DIAGNOSTIC OBSERVATION SCHEDULE; SEXUAL-BEHAVIOR; CONDOM USE; ADULTS;
COMMUNICATION; PERCEPTIONS; ATTITUDES
AB Previous studies have shown that psychosexual functioning in adolescents with autism spectrum disorder (ASD) is hampered and emphasize the need for a specialized training program tailored to their needs. Therefore, an individual training program was developed; the Tackling Teenage Training (TTT) program. The current pilot study systematically evaluated whether psychosexual knowledge increased after taking part in the TTT program, using a pre- and post-training design in 30 adolescents with ASD (77 % male, mean age = 14.80 years, mean intelligence = 96.96). Psychosexual knowledge increased significantly (pre-training total score: M = 25.74, SD = 6.20; post-training total score: M = 33.52 (SD = 2.78); F(1,29) = 65.20, p < .001). The TTT program may be useful to improve psychosexual knowledge and functioning in adolescents with ASD, yet these findings are preliminary, and a more elaborate controlled trial is needed.
C1 [Dekker, Linda P.; van der Vegt, Esther J. M.; Visser, Kirsten; Tick, Nouchka; Verhulst, Frank C.; Greaves-Lord, Kirstin] Erasmus MC Sophia, Dept Child & Adolescent Psychiat Psychol, NL-3015 CN Rotterdam, Netherlands.
[Dekker, Linda P.; van der Vegt, Esther J. M.; Visser, Kirsten; Tick, Nouchka; Boudesteijn, Frieda; Maras, Athanasios; Greaves-Lord, Kirstin] Mental Hlth Org, Yulius, Yulius Acad & Yulius Autism, NL-3013 HH Rotterdam, Netherlands.
RP Dekker, LP (reprint author), Erasmus MC Sophia, Dept Child & Adolescent Psychiat Psychol, Wytemaweg 8,Room KP 2881, NL-3015 CN Rotterdam, Netherlands.
EM l.p.dekker@erasmusmc.nl
FU Sophia Children's Hospital Fund [617]; Anthonia Wilhelimina Fund of the
Psychological Health fund (Fonds Psychische Gezondheid)
FX This project was financially supported by the Sophia Children's Hospital
Fund (Grant Number 617, titled Tackling Teenage: a multicenter study on
psychosexual development and intimacy in adolescents with Autism
Spectrum Disorder). The professionalization of the Tackling Teenage
Training was financially supported by the Anthonia Wilhelimina Fund
which is a part of the Psychological Health fund (i.e. Fonds Psychische
Gezondheid). We are grateful to all adolescents, their parents and the
trainers who participated in this research and to everyone who worked on
this project and made it possible.
CR American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
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NR 34
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1532
EP 1540
DI 10.1007/s10803-014-2301-9
PG 9
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700003
PM 25399394
ER
PT J
AU Minshawi, NF
Hurwitz, S
Morriss, D
McDougle, CJ
AF Minshawi, Noha F.
Hurwitz, Sarah
Morriss, Danielle
McDougle, Christopher J.
TI Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in
Autism Spectrum Disorder and Intellectual Disability: Integration of
Psychological and Biological Theory and Approach
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Intellectual disability; Self-injurious
behavior; Behavior therapy; Pharmacotherapy
ID PRADER-WILLI-SYNDROME; LESCH-NYHAN-SYNDROME; PERVASIVE DEVELOPMENTAL
DISORDERS; MENTALLY RETARDED CHILDREN; PATHOLOGICAL SKIN-PICKING;
DU-CHAT-SYNDROME; DOUBLE-BLIND; CHALLENGING BEHAVIOR; NONCONTINGENT
REINFORCEMENT; ATYPICAL ANTIPSYCHOTICS
AB The objective of this review is to consider the psychological (largely behavioral) and biological [neurochemical, medical (including genetic), and pharmacological] theories and approaches that contribute to current thinking about the etiology and treatment of self-injurious behavior (SIB) in individuals with autism spectrum disorder and/or intellectual disability. Algorithms for the assessment and treatment of SIB in this context, respectively, from a multidisciplinary, integrative perspective are proposed and challenges and opportunities that exist in clinical and research settings are discussed.
C1 [Minshawi, Noha F.] Indiana Univ Sch Med, Dept Psychiat, James Whitcomb Riley Hosp Children, Christian Sarkine Autism Treatment Ctr, Indianapolis, IN 46202 USA.
[Hurwitz, Sarah] Indiana Univ, Sch Educ, Bloomington, IN 47405 USA.
[Morriss, Danielle] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA.
[McDougle, Christopher J.] Massachusetts Gen Hosp, Lurie Ctr Autism, Dept Psychiat, Lexington, MA 02421 USA.
[McDougle, Christopher J.] Massachusetts Gen Hosp, Lurie Ctr Autism, Dept Pediat, Lexington, MA 02421 USA.
[McDougle, Christopher J.] Harvard Univ, Sch Med, MassGen Hosp Children, Lexington, MA 02421 USA.
RP McDougle, CJ (reprint author), Massachusetts Gen Hosp, Lurie Ctr Autism, Dept Psychiat, One Maguire Rd, Lexington, MA 02421 USA.
EM cmcdougle@partners.org
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NR 285
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1541
EP 1568
DI 10.1007/s10803-014-2307-3
PG 28
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700004
PM 25395094
ER
PT J
AU Bull, LE
Oliver, C
Callaghan, E
Woodcock, KA
AF Bull, Leah E.
Oliver, Chris
Callaghan, Eleanor
Woodcock, Kate A.
TI Increased Exposure to Rigid Routines can Lead to Increased Challenging
Behavior Following Changes to Those Routines
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Resistance to change; Restricted preferences; Preference for routine;
Challenging behavior; Temper tantrums; Prader-Willi syndrome
ID PRADER-WILLI-SYNDROME; AUTISM SPECTRUM DISORDERS; PARENT-CHILD
INTERACTIONS; SELF-INJURIOUS-BEHAVIOR; FRAGILE-X-SYNDROME; REPETITIVE
BEHAVIOR; EXECUTIVE FUNCTIONS; TEMPER OUTBURSTS; PEOPLE; FLEXIBILITY
AB Several neurodevelopmental disorders are associated with preference for routine and challenging behavior following changes to routines. We examine individuals with Prader-Willi syndrome, who show elevated levels of this behavior, to better understand how previous experience of a routine can affect challenging behavior elicited by disruption to that routine. Play based challenges exposed 16 participants to routines, which were either adhered to or changed. Temper outburst behaviors, heart rate and movement were measured. As participants were exposed to routines for longer before a change (between 10 and 80 min; within participants), more temper outburst behaviors were elicited by changes. Increased emotional arousal was also elicited, which was indexed by heart rate increases not driven by movement. Further study will be important to understand whether current intervention approaches that limit exposure to changes, may benefit from the structured integration of flexibility to ensure that the opportunity for routine establishment is also limited.
C1 [Bull, Leah E.; Oliver, Chris; Callaghan, Eleanor; Woodcock, Kate A.] Univ Birmingham, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England.
RP Woodcock, KA (reprint author), Queens Univ Belfast, Sch Psychol, Univ Rd, Belfast BT7 1NN, Antrim, North Ireland.
EM k.woodcock@qub.ac.uk
FU Jerome Lejeune Foundation; Cerebra
FX This work was supported by a project grant from the Jerome Lejeune
Foundation to KAW and CO, and Cerebra who provide core funding to the
Cerebra Centre for Neurodevelopmental Disorders (to director CO).
Special thanks to the Prader-Will Syndrome Association, UK and Gretton
Homes for their assistance in recruitment; Emma Cross, Laura Heath-Jones
Campbell, Victoria Johnson, Jessica Penhallow, Amy Perry and Helena
Todd, for assistance with data collection and processing; and Prof. Tony
Holland for advice on project design and assistance with recruitment.
Finally, we are extremely grateful for the support of the participants,
their families and caregivers, without whom the work would not have been
possible.
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NR 49
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1569
EP 1578
DI 10.1007/s10803-014-2308-2
PG 10
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700005
PM 25422033
ER
PT J
AU Pugliese, CE
Anthony, L
Strang, JF
Dudley, K
Wallace, GL
Kenworthy, L
AF Pugliese, Cara E.
Anthony, Laura
Strang, John F.
Dudley, Katerina
Wallace, Gregory L.
Kenworthy, Lauren
TI Increasing Adaptive Behavior Skill Deficits From Childhood to
Adolescence in Autism Spectrum Disorder: Role of Executive Function
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Adaptive behavior; Executive function;
Cognitive ability
ID DEVELOPMENTAL DISORDERS; COMMUNICATION DEFICITS; DIAGNOSTIC INTERVIEW;
ASPERGER-SYNDROME; REAL-WORLD; INDIVIDUALS; CHILDREN; VINELAND; MIND;
ABILITIES
AB Almost half of all children with autism spectrum disorder have average cognitive abilities, yet outcome remains poor. Because outcome in HFASD is more related to adaptive behavior skills than cognitive level it is important to identify predictors of adaptive behavior. This study examines cognitive and demographic factors related to adaptive behavior, with specific attention to the role of executive function (EF) in youth with HFASD aged 4-23. There was a negative relationship between age and adaptive behavior and the discrepancy between IQ and adaptive behavior increased with age. EF problems contributed to lower adaptive behavior scores across domains. As such, it is important to target adaptive skills, and the EF problems that may contribute to them, in youth with HFASD.
C1 [Pugliese, Cara E.; Anthony, Laura; Strang, John F.; Dudley, Katerina; Kenworthy, Lauren] Childrens Natl Hlth Syst, Ctr Autism Spectrum Disorders, Div Neuropsychol, Rockville, MD USA.
[Pugliese, Cara E.] Childrens Res Inst, Ctr Autism Spectrum Disorders, Div Neuropsychol, Rockville, MD 20850 USA.
[Wallace, Gregory L.] George Washington Univ, Dept Speech & Hearing Sci, Washington, DC USA.
RP Pugliese, CE (reprint author), Childrens Res Inst, Ctr Autism Spectrum Disorders, Div Neuropsychol, 15245 Shady Grove Rd 350, Rockville, MD 20850 USA.
EM CPuglies@childrensnational.org
FU Isadore and Bertha Gudelsky Family Foundation; National Institutes of
Health [P30HD040677, T32 HD046388-01A2]
FX This work was supported by an award from the Isadore and Bertha Gudelsky
Family Foundation and Grants by the National Institutes of Health
(P30HD040677 and T32 HD046388-01A2).
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NR 41
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1579
EP 1587
DI 10.1007/s10803-014-2309-1
PG 9
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700006
PM 25398602
ER
PT J
AU Mehling, MH
Tasse, MJ
AF Mehling, Margaret H.
Tasse, Marc J.
TI Impact of Choice on Social Outcomes of Adults with ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Social relationships; Social participation; Access to services;
Personal control; National core indicators
ID QUALITY-OF-LIFE; RECEPTIVE LANGUAGE DISORDER; HIGH-FUNCTIONING ADULTS;
FOLLOW-UP; ASPERGER-SYNDROME; AUTISM; DISABILITIES; ADOLESCENTS;
PREDICTORS; CHILDHOOD
AB This study explores social outcomes for adults with autism spectrum disorder (ASD) in comparison to adults with developmental disabilities other than ASD by investigating the relationships between the constructs Social Participation and Relationships, Social Determination, and Personal Control. Structural equation modeling (SEM) was used to test a model of the relationships among constructs of interest and structured means analysis was used to test for mean group differences on these constructs. Results indicated that individuals with ASD had lower levels of Social Determination and Friendships than individuals with other developmental disabilities. SEM analyses yielded significant relationships between constructs. Results provide insight with regards to novel statistical, theoretical, and practical approaches to the study of social outcomes for individuals with ASD.
C1 [Mehling, Margaret H.; Tasse, Marc J.] Ohio State Univ, Nisonger Ctr, Columbus, OH 43210 USA.
RP Mehling, MH (reprint author), Ohio State Univ, Nisonger Ctr, 279 McCambbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
EM mehling.19@osu.edu; Marc.tasse@osumc.edu
FU U.S. Administration on Intellectual and Developmental Disabilities Grant
[99-DD-0621]
FX The authors would like to acknowledge Robert Cudeck, Ph.D. and Rebecca
Andridge Ph.D. for their consultation regarding the statistical analyses
carried out in this study. Authors would also like to acknowledge Human
Services Research Institute (HSRI) and the National Association of State
Directors of Developmental Disabilities Services (NASDDDS) and thank
these organizations for their contribution of the National Core
Indicators (NCI) dataset to this study. This study was supported in part
with funding from the U.S. Administration on Intellectual and
Developmental Disabilities Grant #99-DD-0621.
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NR 41
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1588
EP 1602
DI 10.1007/s10803-014-2312-6
PG 15
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700007
PM 25413143
ER
PT J
AU Robic, S
Sonie, S
Fonlupt, P
Henaff, MA
Touil, N
Coricelli, G
Mattout, J
Schmitz, C
AF Robic, S.
Sonie, S.
Fonlupt, P.
Henaff, M. -A.
Touil, N.
Coricelli, G.
Mattout, J.
Schmitz, C.
TI Decision-Making in a Changing World: A Study in Autism Spectrum
Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Social; Instability; Decision-making
ID HIGH-FUNCTIONING AUTISM; CINGULATE CORTEX; SOCIAL-STIMULI; NORMAL
ADULTS; CHILDREN; ATTENTION; INFERENCE; BEHAVIOR; ORIENT
AB To learn to deal with the unexpected is essential to adaptation to a social, therefore often unpredictable environment. Fourteen adults with autism spectrum disorders (ASD) and 15 controls underwent a decision-making task aimed at investigating the influence of either a social or a non-social environment, and its interaction with either a stable (with constant probabilities) or an unstable (with changing probabilities) context on their performance. Participants with ASD presented with difficulties in accessing underlying statistical rules in an unstable context, a deficit especially enhanced in the social environment. These results point out that the difficulties people with ASD encounter in their social life might be caused by impaired social cues processing and by the unpredictability associated with the social world.
C1 [Robic, S.; Sonie, S.; Fonlupt, P.; Henaff, M. -A.; Mattout, J.; Schmitz, C.] CNRS, INSERM, Lyon Neurosci Res Ctr, Brain Dynam & Cognit Team,UMR 5292,U1028, Lyon, France.
[Robic, S.; Sonie, S.; Fonlupt, P.; Henaff, M. -A.; Mattout, J.; Schmitz, C.] Univ Lyon, Lyon, France.
[Sonie, S.] Le Vinatier Hosp, CEDA, Bron, France.
[Touil, N.] CHU Lyon, EPICIME CIC, Bron, France.
[Coricelli, G.] Ecole Normale Super, INSERM, U960, Lab Neurosci Cognit, F-75231 Paris, France.
RP Schmitz, C (reprint author), CNRS, INSERM, Lyon Neurosci Res Ctr, Brain Dynam & Cognit Team,UMR 5292,U1028, Lyon, France.
EM christina.schmitz@inserm.fr
FU Scientific Research Council from Vinatier Hospital Center; LABEX CORTEX
of Universite de Lyon within program "Investissements d'Avenir''
[ANR-11-LABX-0042, ANR-11-IDEX-0007]
FX We would like to thank all of the participants for making this research
possible. This study was supported by a Scientific Research Council
grant from the Vinatier Hospital Center; the work was performed within
the framework of the LABEX CORTEX (ANR-11-LABX-0042) of Universite de
Lyon, within the program "Investissements d'Avenir'' (ANR-11-IDEX-0007)
operated by the French National Research Agency (ANR).
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Sasson N, 2007, NEUROPSYCHOLOGIA, V45, P2580, DOI 10.1016/j.neuropsychologia.2007.03.009
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Schwartz D., 1963, METHODS STAT USAGE M, P67
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NR 42
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1603
EP 1613
DI 10.1007/s10803-014-2311-7
PG 11
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700008
PM 25433404
ER
PT J
AU Paynter, JM
Keen, D
AF Paynter, Jessica M.
Keen, Deb
TI Knowledge and Use of Intervention Practices by Community-Based Early
Intervention Service Providers
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Evidence-based practice; Implementation; Knowledge transfer; Early
intervention; Research-practice gap
ID AUTISM SPECTRUM DISORDERS; CHILDREN; PROGRAMS; THERAPY; PARENTS; SCHOOLS
AB This study investigated staff attitudes, knowledge and use of evidence-based practices (EBP) and links to organisational culture in a community-based autism early intervention service. An EBP questionnaire was completed by 99 metropolitan and regionally-based professional and paraprofessional staff. Participants reported greater knowledge and use of EBPs compared to emerging and unsupported practices. Knowledge and use of EBPs were linked to each other independent of significant correlations with organisational culture and attitudes. Knowledge and use of EBPs was greater in metropolitan than regional locations and paraprofessionals reported greater use of unsupported practices and lower levels of knowledge and use of EBPs than professionals. The implications of these findings for the facilitation of knowledge transfer are discussed.
C1 [Paynter, Jessica M.] AEIOU Fdn, Nathan, Qld 4111, Australia.
[Paynter, Jessica M.] Mater Res Inst UQ, South Brisbane, Qld 4101, Australia.
[Keen, Deb] Griffith Univ, Mt Gravatt, Qld 4122, Australia.
RP Paynter, JM (reprint author), AEIOU Fdn, 66 Hamilton Rd,POB 226, Nathan, Qld 4111, Australia.
EM jessica.paynter@aeiou.org.au; d.keen@griffith.edu.au
FU AEIOU Foundation
FX We wish to thank the AEIOU Foundation Staff who gave their time to
participate in this study, and AEIOU Foundation for their support of
this project.
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Carter M, 2011, RES AUTISM SPECT DIS, V5, P1033, DOI 10.1016/j.rasd.2010.11.009
Center N. A., 2009, NATL STANDARDS PROJE
Centers for Disease Control Prevention (CDC), 2014, MMWR RECOMM REP, V63, P1
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Kadar M, 2012, AUST OCCUP THER J, V59, P284, DOI 10.1111/j.1440-1630.2012.01015.x
Lang R, 2012, RES AUTISM SPECT DIS, V6, P1004, DOI 10.1016/j.rasd.2012.01.006
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National Autism Center, 2009, NAT STAND REP ADDR N
Odom S. L., 2010, PREVENTING SCH FAILU, V54, P275, DOI DOI 10.1080/10459881003785506
Olsen S, 2012, VOLTA REV, V112, P267
Parsons S, 2013, AUTISM, V17, P268, DOI 10.1177/1362361312472068
Paynter J., 2012, OPEN PEDIAT MED J, V6, P7
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Stephenson J, 2009, AUST J EDUC, V53, P109
Wong C., 2013, EVIDENCE BASED PRACT
NR 26
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1614
EP 1623
DI 10.1007/s10803-014-2316-2
PG 10
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700009
PM 25398604
ER
PT J
AU Ledford, JR
Wehby, JH
AF Ledford, Jennifer R.
Wehby, Joseph H.
TI Teaching Children with Autism in Small Groups with Students Who are
At-Risk for Academic Problems: Effects on Academic and Social Behaviors
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Small group instruction; Social skills; Progressive time delay
ID GROUP DIRECT INSTRUCTION; SPECTRUM DISORDER; PEER INTERACTIONS
AB Students with ASD are often taught in individual instructional arrangements, even when they receive educational services in inclusive settings. Providing intervention in small group arrangements may increase opportunities for social interactions, particularly when these opportunities are systematically planned. In this study, academic instruction was conducted in small groups consisting of one student with ASD and peers who were socially competent but at risk for academic failure. All students learned targeted academic behaviors and increased their use of targeted social behaviors during instructional sessions. Generalization of social behaviors to a less-structured context was variable. Results suggest that small group instruction may be a feasible and preferred alternative to individual instruction for students with ASD.
C1 [Ledford, Jennifer R.; Wehby, Joseph H.] Vanderbilt Univ, Peabody Coll, Dept Special Educ, Nashville, TN 37203 USA.
RP Ledford, JR (reprint author), Vanderbilt Univ, Peabody Coll, Dept Special Educ, Box 228, Nashville, TN 37203 USA.
EM jennifer.ledford@vanderbilt.edu
FU Institute of Education Sciences [R324B130014]
FX Funding for this review was provided by the Institute of Education
Sciences (Grant #R324B130014).
CR BILLINGSLEY F, 1980, BEHAV ASSESS, V2, P229
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Council for Exceptional Children, 2010, SPEC ED PROF PRINC P
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Oliver R. M., 2007, EFFECTIVE CLASSROOM
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Wong C., 2014, EVIDENCE BASED PRACT
NR 24
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1624
EP 1635
DI 10.1007/s10803-014-2317-1
PG 12
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700010
PM 25409705
ER
PT J
AU Hartley, SL
Schultz, HM
AF Hartley, Sigan L.
Schultz, Haley M.
TI Support Needs of Fathers and Mothers of Children and Adolescents with
Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Support; Services; Parent; Father
ID FRAGILE-X-SYNDROME; DOWN-SYNDROME; BEHAVIOR PROBLEMS; SOCIAL SUPPORT;
YOUNG-CHILDREN; PARENTS; DISABILITIES; STRESS; HEALTH; FAMILIES
AB Little research has examined the support needs of mothers versus fathers of children and adolescents with autism spectrum disorder (ASD). We identified and compared the important and unmet support needs of mothers and fathers, and evaluated their association with family and child factors, within 73 married couples who had a child or adolescent with ASD. Mothers had a higher number of important support needs and higher proportion of important support needs that are unmet than fathers. Multilevel modeling indicated that child age, co-occurring behavior problems, presence of intellectual disability, parent education, and household income were related to support needs. Findings offer insight into the overlapping and unique support needs of mothers and fathers of children and adolescents with ASD.
C1 [Hartley, Sigan L.] Univ Wisconsin, Waisman Ctr, Dept Human Dev & Family Studies, Madison, WI 53705 USA.
[Schultz, Haley M.] Univ Wisconsin, Waisman Ctr, Dept Rehabil Psychol, Madison, WI 53705 USA.
RP Hartley, SL (reprint author), Univ Wisconsin, Waisman Ctr, Dept Human Dev & Family Studies, 1500 Highland Ave, Madison, WI 53705 USA.
EM hartley@waisman.wisc.edu
FU University of Wisconsin Graduate School; National Institute on Mental
Health [R01MH099190]; National Institute on Child Health and Human
Development [P30 HD03352]
FX This research was supported by Grants from the University of Wisconsin
Graduate School (to S. Hartley), National Institute on Mental Health
(R01MH099190 to S. Hartley), and the National Institute on Child Health
and Human Development (P30 HD03352 to M. Seltzer). We would like to
thank the families who participated in this study for their ongoing
support.
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NR 45
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1636
EP 1648
DI 10.1007/s10803-014-2318-0
PG 13
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700011
PM 25433405
ER
PT J
AU Garg, S
Plasschaert, E
Descheemaeker, MJ
Huson, S
Borghgraef, M
Vogels, A
Evans, DG
Legius, E
Green, J
AF Garg, Shruti
Plasschaert, Ellen
Descheemaeker, Mie-Jef
Huson, Susan
Borghgraef, Martine
Vogels, Annick
Evans, D. Gareth
Legius, Eric
Green, Jonathan
TI Autism Spectrum Disorder Profile in Neurofibromatosis Type I
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE NF1; ASD; Neurofibromatosis Type 1; Autism spectrum disorder; SRS; ADOS
ID CONTROLLED-TRIAL; MOUSE MODEL; CHILDREN; POPULATION; PREVALENCE;
DEFICITS; SIMVASTATIN; GENETICS; TRAITS; NF1
AB Neurofibromatosis Type 1 (NF1) is a common autosomal dominant single-gene disorder, in which the co-occurrence of autism spectrum disorder (ASD) has attracted considerable research interest recently with prevalence estimates of 21-40 %. However, detailed characterization of the ASD behavioral phenotype in NF1 is still lacking. This study characterized the phenotypic profile of ASD symptomatology presenting in 4-16 year old children with NF1 (n = 36) using evidence from parent-rated Social Responsiveness Scale and researcher autism diagnostic observation Scale-2. Compared to IQ-matched reference groups of children with autism and ASD, the NF1 profile shows overall similarity but improved eye contact, less repetitive behaviors and better language skills.
C1 [Garg, Shruti; Green, Jonathan] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester M13 9PL, Lancs, England.
[Plasschaert, Ellen; Descheemaeker, Mie-Jef; Borghgraef, Martine; Vogels, Annick; Legius, Eric] Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium.
[Plasschaert, Ellen; Vogels, Annick; Legius, Eric] Univ Hosp Leuven, Dept Human Genet, B-3000 Leuven, Belgium.
[Plasschaert, Ellen; Descheemaeker, Mie-Jef] Katholieke Univ Leuven, Leuven Autism Res LAuRes, Leuven, Belgium.
[Huson, Susan; Evans, D. Gareth] Univ Manchester, Cent Manchester Univ Hosp NHS Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr,Inst Human Dev,Genom, Manchester M13 9WL, Lancs, England.
RP Green, J (reprint author), Univ Manchester, Inst Brain Behav & Mental Hlth, Oxford Rd, Manchester M13 9PL, Lancs, England.
EM Eric.legius@uzleuven.be; Jonathan.green@manchester.ac.uk
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NR 40
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1649
EP 1657
DI 10.1007/s10803-014-2321-5
PG 9
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700012
PM 25475362
ER
PT J
AU Duvekot, J
van der Ende, J
Verhulst, FC
Greaves-Lord, K
AF Duvekot, Jorieke
van der Ende, Jan
Verhulst, Frank C.
Greaves-Lord, Kirstin
TI The Screening Accuracy of the Parent and Teacher-Reported Social
Responsiveness Scale (SRS): Comparison with the 3Di and ADOS
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Social Responsiveness Scale (SRS); Autism spectrum disorder (ASD);
Screening; Multi-informant
ID AUTISM SPECTRUM DISORDERS; PERVASIVE DEVELOPMENTAL DISORDERS;
DIAGNOSTIC-OBSERVATION-SCHEDULE; IV-TR CLASSIFICATION; ADI-R; COMBINING
INFORMATION; MENTAL-RETARDATION; REVISED ALGORITHMS; SYMPTOM SEVERITY;
MULTIPLE SOURCES
AB The screening accuracy of the parent and teacher-reported Social Responsiveness Scale (SRS) was compared with an autism spectrum disorder (ASD) classification according to (1) the Developmental, Dimensional, and Diagnostic Interview (3Di), (2) the Autism Diagnostic Observation Schedule (ADOS), (3) both the 3Di and ADOS, in 186 children referred to six mental health centers. The parent report showed excellent correspondence to an ASD classification according to the 3Di and both the 3Di and ADOS. The teacher report added significantly to the screening accuracy over and above the parent report when compared with the ADOS classification. Findings support the screening utility of the parent-reported SRS among clinically referred children and indicate that different informants may provide unique information relevant for ASD assessment.
C1 [Duvekot, Jorieke; van der Ende, Jan; Verhulst, Frank C.; Greaves-Lord, Kirstin] Erasmus MC Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, NL-3015 CN Rotterdam, Netherlands.
[Duvekot, Jorieke; Greaves-Lord, Kirstin] Yulius Mental Hlth, Yulius Acad, NL-3300 AT Dordrecht, Netherlands.
RP Greaves-Lord, K (reprint author), Erasmus MC Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Wytemaweg 8, NL-3015 CN Rotterdam, Netherlands.
EM k.greaves-lord@erasmusmc.nl
FU Sophia Foundation for Scientific Research (SSWO) [958]
FX We gratefully acknowledge the contribution of all graduate students,
PhD-students, and research assistants involved in the study, as well as
the clinical professionals, management and administrative staff of the
participating mental health care centers: Emergis, Erasmus MC-Sophia
Children's Hospital, GGZ WNB, Lucertis, Riagg Rijnmond, Yulius. We thank
all children and parents who participated in the study. This research
was supported by a Grant from the Sophia Foundation for Scientific
Research (SSWO; project number 958).
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NR 74
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1658
EP 1672
DI 10.1007/s10803-014-2323-3
PG 15
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700013
PM 25428292
ER
PT J
AU Van Hees, V
Moyson, T
Roeyers, H
AF Van Hees, Valerie
Moyson, Tinneke
Roeyers, Herbert
TI Higher Education Experiences of Students with Autism Spectrum Disorder:
Challenges, Benefits and Support Needs
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; Higher education; Qualitative research; Students' challenges;
Benefits; Support needs and recommendations
ID ASPERGER SYNDROME; COLLEGE-STUDENTS; INDIVIDUALS; ADOLESCENTS;
TRANSITION; ADULTHOOD; MIND; DISABILITIES; PERSPECTIVE; LONELINESS
AB The transition into higher education constitutes a precarious life stage for students with autism spectrum disorder (ASD). Research on how students with ASD navigate college life is needed for the development of adequate support. This study investigated the challenges and support needs of 23 students with ASD in higher education through semi-structured interviews. Data were analyzed following the principles of Grounded Theory. Students faced difficulties with new situations and unexpected changes, social relationships, problems with information processing and time management and had doubts about disclosure. Facing these challenges simultaneously in the domains of education, student life and daily (independent) living, had a major impact on students' well being. Besides these challenges, students also reported benefits that contributed to success in the three domains. They pointed out to a set of recommendations for support. These findings are linked with previous research and implications for higher education institutions are extrapolated on the basis of these findings.
C1 [Van Hees, Valerie] Artevelde Univ Coll Ghent, Off Study & Career Guidance, B-9000 Ghent, Belgium.
[Moyson, Tinneke] Univ Coll Ghent, Dept Educ Hlth & Social Work, B-9000 Ghent, Belgium.
[Roeyers, Herbert] Univ Ghent, Dept Expt Clin & Hlth Psychol, B-9000 Ghent, Belgium.
RP Van Hees, V (reprint author), Artevelde Univ Coll Ghent, Off Study & Career Guidance, Hoogpoort 15, B-9000 Ghent, Belgium.
EM Valerie.Vanhees@arteveldehs.be; Tinneke.Moyson@HoGent.be;
Herbert.Roeyers@UGent.be
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NR 60
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1673
EP 1688
DI 10.1007/s10803-014-2324-2
PG 16
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700014
PM 25448918
ER
PT J
AU Rosen, BN
Lee, BK
Lee, NL
Yang, YW
Burstyn, I
AF Rosen, Brittany N.
Lee, Brian K.
Lee, Nora L.
Yang, Yunwen
Burstyn, Igor
TI Maternal Smoking and Autism Spectrum Disorder: A Meta-analysis
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Tobacco smoke; Epidemiology; Systematic review; In-utero
exposure; Environmental risk; Exposure misclassification
ID PERINATAL RISK-FACTORS; COMPREHENSIVE METAANALYSIS;
DEVELOPMENTAL-DISABILITIES; SOCIOECONOMIC-STATUS; INFANTILE-AUTISM;
NEONATAL FACTORS; PREGNANCY; POPULATION; BIRTH; PREVALENCE
AB We conducted a meta-analysis of 15 studies on maternal prenatal smoking and ASD risk in offspring. Using a random-effects model, we found no evidence of an association (summary OR 1.02, 95 % CI 0.93-1.12). Stratifying by study design, birth year, type of healthcare system, and adjustment for socioeconomic status or psychiatric history did not alter the findings. There was evidence that ascertaining exposure at the time of birth produced a lower summary OR than when this information was gathered after birth. There was no evidence of publication bias. Non-differential exposure misclassification was shown to have the potential for negligible influence on the results. We found no evidence to support a measurable association between maternal prenatal smoking and ASD in offspring.
C1 [Rosen, Brittany N.; Burstyn, Igor] Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Philadelphia, PA 19104 USA.
[Lee, Brian K.; Lee, Nora L.; Yang, Yunwen; Burstyn, Igor] Drexel Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.
RP Burstyn, I (reprint author), Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Nesbitt Hall,Room 614,3215 Market St, Philadelphia, PA 19104 USA.
EM igor.burstyn@drexel.edu
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NR 46
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1689
EP 1698
DI 10.1007/s10803-014-2327-z
PG 10
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700015
PM 25432101
ER
PT J
AU Klusek, J
Hunt, AW
Mirrett, PL
Hatton, DD
Hooper, SR
Roberts, JE
Bailey, DB
AF Klusek, Jessica
Hunt, Anna W.
Mirrett, Penny L.
Hatton, Deborah D.
Hooper, Stephen R.
Roberts, Jane E.
Bailey, Donald B.
TI Reading and Phonological Skills in Boys with Fragile X Syndrome
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Fragile X syndrome; Autism spectrum disorder; Literacy; Reading;
Phonological skills; Phonological awareness
ID AUTISM SPECTRUM DISORDERS; DOWN-SYNDROME; WORKING-MEMORY; YOUNG MALES;
LEITER-R; DEVELOPMENTAL TRAJECTORIES; BEHAVIORAL-PHENOTYPE; LANGUAGE
IMPAIRMENT; CONCURRENT VALIDITY; PANELS METAANALYSIS
AB Although reading skills are critical for the success of individuals with intellectual disabilities, literacy has received little attention in fragile X syndrome (FXS). This study examined the literacy profile of FXS. Boys with FXS (n = 51; mean age 10.2 years) and mental age-matched boys with typical development (n = 35) participated in standardized assessments of reading and phonological skills. Phonological skills were impaired in FXS, while reading was on-par with that of controls. Phonological awareness predicted reading ability and ASD severity predicted poorer phonological abilities in FXS. Boys with FXS are capable of attaining reading skills that are commensurate with developmental level and phonological awareness skills may play a critical role in reading achievement in FXS.
C1 [Klusek, Jessica] Univ S Carolina, Barnwell Coll, Dept Psychol, Columbia, SC 29208 USA.
[Hunt, Anna W.] Clarity, Greenville, SC USA.
[Mirrett, Penny L.] Univ S Carolina, Frank Porter Graham Child Dev Inst, Columbia, SC 29208 USA.
[Hatton, Deborah D.] Vanderbilt Univ, Kennedy Ctr, Nashville, TN 37235 USA.
[Hooper, Stephen R.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
[Hooper, Stephen R.] Univ N Carolina, Dept Allied Hlth Sci, Chapel Hill, NC USA.
[Roberts, Jane E.] Univ S Carolina, Dept Psychol, Columbia, SC 29208 USA.
[Bailey, Donald B.] RTI Int, Res Triangle Pk, NC USA.
RP Klusek, J (reprint author), Univ S Carolina, Barnwell Coll, Dept Psychol, 1512 Pendleton St, Columbia, SC 29208 USA.
EM klusek@mailbox.sc.edu
FU Office of Special Education and Rehabilitative Services of the U.S.
Department of Education [H324C010007]; National Institutes of Health
[F32DC013934, R01MH090194, R01HD40602, R01HD024356]
FX This research supported by the Office of Special Education and
Rehabilitative Services of the U.S. Department of Education Grant
(H324C010007), the National Institutes of Health (F32DC013934;
R01MH090194; R01HD40602; R01HD024356). Components of this paper were
completed as part of the dissertation of Anna L. Hunt (Williams) at the
School of Education, University of North Carolina at Chapel Hill. We
would like to acknowledge John Sideris for his assistance with the
statistical models for earlier drafts of this manuscript. We also thank
the children and families who participated in this research.
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NR 91
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1699
EP 1711
DI 10.1007/s10803-014-2328-y
PG 13
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700016
PM 25448919
ER
PT J
AU Shire, SY
Goods, K
Shih, W
Distefano, C
Kaiser, A
Wright, C
Mathy, P
Landa, R
Kasari, C
AF Shire, Stephanie Y.
Goods, Kelly
Shih, Wendy
Distefano, Charlotte
Kaiser, Ann
Wright, Courtney
Mathy, Pamela
Landa, Rebecca
Kasari, Connie
TI Parents' Adoption of Social Communication Intervention Strategies:
Families Including Children with Autism Spectrum Disorder Who are
Minimally Verbal
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Parent training; Autism; Minimally verbal; Intervention; Coaching
ID JOINT ATTENTION; PSYCHOSOCIAL INTERVENTIONS; LANGUAGE; DISABILITIES;
GROWTH; TRIAL
AB Notably absent from the intervention literature are parent training programs targeting school-aged children with autism who have limited communication skills (Tager-Flusberg and Kasari in Autism Res 6:468-478, 2013). Sixty-one children with autism age 5-8 with minimal spontaneous communication received a 6-month social communication intervention including parent training. Parent-child play interactions were coded for parents' strategy implementation and children's time jointly engaged (Adamson et al. in J Autism Dev Disord 39:84-96, 2009). Parents mastered an average of 70 % of the strategies. Further analyses indicated some gains in implementation occurred from mere observation of sessions, while the greatest gains occurred in the first month of active coaching and workshops. Children's joint engagement was associated with parents' implementation success across time demonstrating parents' implementation was relevant to children's social engagement.
C1 [Shire, Stephanie Y.] Univ Calif Los Angeles, Dept Psychiat, Neuropsychiat Inst NPI 67 448, Los Angeles, CA 90024 USA.
[Shire, Stephanie Y.; Goods, Kelly; Shih, Wendy; Distefano, Charlotte; Kasari, Connie] Univ Calif Los Angeles, Ctr Autism Res & Treatment, Los Angeles, CA 90024 USA.
[Goods, Kelly] First Five Calif, Los Angeles, CA 90012 USA.
[Shih, Wendy] Univ Calif Los Angeles, Dept Biostat, Neuropsychiat Inst NPI 67 448, Los Angeles, CA 90024 USA.
[Kaiser, Ann; Wright, Courtney] Vanderbilt Univ, Educ & Human Dev, Nashville, TN 37203 USA.
[Wright, Courtney] Vanderbilt Univ, Dept Special Educ, Nashville, TN 37203 USA.
[Mathy, Pamela; Landa, Rebecca] Kennedy Krieger Inst, Ctr Autism & Related Disorders, Baltimore, MD 21211 USA.
RP Shire, SY (reprint author), Univ Calif Los Angeles, Dept Psychiat, Neuropsychiat Inst NPI 67 448, 760 Westwood Plaza, Los Angeles, CA 90024 USA.
EM sypatterson@ucla.edu; wshih@mednet.ucla.edu; cmucchetti@mednet.ucla.edu;
ann.kaiser@vanderbilt.edu; courtney.a.wright@vanderbilt.edu;
Pamela.Mathy@hsc.utah.edu; Landa@kennedykrieger.org;
ckasari@mednet.ucla.edu
FU Autism Speaks [5666, 7036]; Canadian Institutes for Health Research
FX We would like to acknowledge funding for the study provided by Autism
Speaks (PI Kasari: #5666), Characterizing Cognition in Nonverbal
Individuals with Autism. In addition, the first author received a Dennis
Weatherstone Pre-Doctoral Fellowship from Autism Speaks (#7036) as well
a Doctoral Foreign Study Award from the Canadian Institutes for Health
Research. Thank you to the children and families who participated in
this study as well as interventionists who provided the services across
the three sites. A version of this paper was presented at the 2013
Biennial Meeting of the Society for Research in Child Development in
Seattle Washington and was developed from a master's thesis.
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NR 35
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1712
EP 1724
DI 10.1007/s10803-014-2329-x
PG 13
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700017
PM 25475363
ER
PT J
AU Joseph, JE
Zhu, X
Gundran, A
Davies, F
Clark, JD
Ruble, L
Glaser, P
Bhatt, RS
AF Joseph, Jane E.
Zhu, Xun
Gundran, Andrew
Davies, Faraday
Clark, Jonathan D.
Ruble, Lisa
Glaser, Paul
Bhatt, Ramesh S.
TI Typical and Atypical Neurodevelopment for Face Specialization: An fMRI
Study
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Face processing; Typical development; Autism spectrum disorder;
Undiagnosed siblings; fMRI
ID AUTISM SPECTRUM DISORDERS; PLACE-RELATED CORTEX; OBJECT RECOGNITION;
FUNCTIONAL CONNECTIVITY; BRAIN ACTIVATION; IMAGING ENDOPHENOTYPE; FACIAL
EXPRESSION; AMYGDALA RESPONSE; ASPERGER-SYNDROME; NEURAL CIRCUITRY
AB Individuals with autism spectrum disorder (ASD) and their relatives process faces differently from typically developed (TD) individuals. In an fMRI face-viewing task, TD and undiagnosed sibling (SIB) children (5-18 years) showed face specialization in the right amygdala and ventromedial prefrontal cortex, with left fusiform and right amygdala face specialization increasing with age in TD subjects. SIBs showed extensive antero-medial temporal lobe activation for faces that was not present in any other group, suggesting a potential compensatory mechanism. In ASD, face specialization was minimal but increased with age in the right fusiform and decreased with age in the left amygdala, suggesting atypical development of a frontal-amygdala-fusiform system which is strongly linked to detecting salience and processing facial information.
C1 [Joseph, Jane E.; Zhu, Xun; Gundran, Andrew; Davies, Faraday] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA.
[Clark, Jonathan D.; Glaser, Paul] Univ Kentucky, Albert B Chandler Med Ctr, Dept Anat & Neurobiol, Lexington, KY 40536 USA.
[Ruble, Lisa] Univ Kentucky, Dept Educ Sch & Counseling Psychol, Lexington, KY USA.
[Glaser, Paul] Univ Kentucky, Dept Psychiat, Lexington, KY USA.
[Bhatt, Ramesh S.] Univ Kentucky, Dept Psychol, Lexington, KY 40506 USA.
RP Joseph, JE (reprint author), Med Univ S Carolina, Dept Neurosci, Clin Sci Bldg,Room 325E,MSC 616, Charleston, SC 29425 USA.
EM josep@musc.edu; zhuxun@musc.edu; andrewgundran0@gmail.com;
faradaydavies@gmail.com; jdclar3@uky.edu; lisa.ruble@uky.edu;
pglas0@email.uky.edu; rbhatt@uky.edu
FU Autism Speaks; National Institutes of Health [R01 HD052724, R01
HD042452]
FX This research was sponsored by Autism Speaks and the National Institutes
of Health (R01 HD052724, R01 HD042452). We thank Christine Corbly, Myra
Huffman and Melissa Wheatley for assistance with data collection and
Michelle DiBartolo for help with manuscript preparation.
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NR 86
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1725
EP 1741
DI 10.1007/s10803-014-2330-4
PG 17
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700018
PM 25479816
ER
PT J
AU VanderLaan, DP
Leef, JH
Wood, H
Hughes, SK
Zucker, KJ
AF VanderLaan, Doug P.
Leef, Jonathan H.
Wood, Hayley
Hughes, S. Kathleen
Zucker, Kenneth J.
TI Autism Spectrum Disorder Risk Factors and Autistic Traits in Gender
Dysphoric Children
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Gender dysphoria; Autism spectrum disorder; Birth weight; Parental age;
Sibling sex ratio
ID SIBLING SEX-RATIO; PREHOMOSEXUAL FEMININE BOYS; IDENTITY DISORDER;
BIRTH-WEIGHT; ADOLESCENTS; PREGNANCY; ORDER; RECALL; INDIVIDUALS; GROWTH
AB Gender dysphoria (GD) and autism spectrum disorder (ASD) are associated. In 49 GD children (40 natal males), we examined ASD risk factors (i.e., birth weight, parental age, sibling sex ratio) in relation to autistic traits. Data were gathered on autistic traits, birth weight, parents' ages at birth, sibling sex ratio, gender nonconformity, age, maternal depression, general behavioral and emotional problems, and IQ. High birth weight was associated with both high gender nonconformity and autistic traits among GD children. Developmental processes associated with high birth weight are, therefore, likely to underlie the GD-ASD link either directly or indirectly. The present study is the first to provide quantitative data bearing on possible mechanisms that lead GD and ASD to co-occur.
C1 [VanderLaan, Doug P.; Leef, Jonathan H.; Wood, Hayley; Hughes, S. Kathleen; Zucker, Kenneth J.] Ctr Addict & Mental Hlth, Gender Ident Serv, Beamish Family Wing, Child Serv, Toronto, ON M6J 1H4, Canada.
[VanderLaan, Doug P.; Leef, Jonathan H.; Wood, Hayley; Hughes, S. Kathleen; Zucker, Kenneth J.] Ctr Addict & Mental Hlth, Gender Ident Serv, Beamish Family Wing, Youth Serv, Toronto, ON M6J 1H4, Canada.
[VanderLaan, Doug P.; Leef, Jonathan H.; Wood, Hayley; Hughes, S. Kathleen; Zucker, Kenneth J.] Ctr Addict & Mental Hlth, Gender Ident Serv, Beamish Family Wing, Family Serv, Toronto, ON M6J 1H4, Canada.
[Zucker, Kenneth J.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
RP VanderLaan, DP (reprint author), Ctr Addict & Mental Hlth, Gender Ident Serv, Beamish Family Wing, Child Serv, 80 Workman Way,5th Floor, Toronto, ON M6J 1H4, Canada.
EM doug.vanderlaan@camh.ca
FU Canadian Institutes of Health Research
FX D.P.V. was supported by a Canadian Institutes of Health Research
Postdoctoral Fellowship. We thank two anonymous reviewers for comments
on an earlier version of this article.
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NR 57
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1742
EP 1750
DI 10.1007/s10803-014-2331-3
PG 9
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700019
PM 25503304
ER
PT J
AU Mattison, MLA
Dando, CJ
Ormerod, TC
AF Mattison, Michelle L. A.
Dando, Coral J.
Ormerod, Thomas C.
TI Sketching to Remember: Episodic Free Recall Task Support for Child
Witnesses and Victims with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Cognitive interview; Drawing; Free recall;
Eyewitness
ID FRONTLINE POLICE INVESTIGATORS; SCHOOL-AGE-CHILDREN; COGNITIVE
INTERVIEW; MENTAL REINSTATEMENT; ASPERGERS-SYNDROME; CONTEXT
REINSTATEMENT; EYEWITNESS MEMORY; ADULTS; EVENTS; ABILITY
AB Deficits in episodic free-recall memory performance have been reported in children with autism spectrum disorder (ASD), yet best practice dictates that child witness/victim interviews commence with a free-recall account. No 'tools' exist to support children with ASD to freely recall episodic information. Here, the efficacy of a novel retrieval technique, Sketch reinstatement of context (Sketch-RC), is compared with mental reinstatement of context and a no support control. Ninety children (45 with ASD; 45 matched typically developing) viewed a stimulus film, and were interviewed using one of the aforementioned techniques. The Sketch-RC technique was most effective, improving ASD participants' remembering without a concomitant increase in intrusions. This procedure offers a population-appropriate method for supporting free recall in criminal justice settings.
C1 [Mattison, Michelle L. A.] Univ Chester, Dept Psychol, Chester CH1 4BJ, Cheshire, England.
[Dando, Coral J.] Wolverhampton Univ, Inst Psychol, Wolverhampton WV1 1DJ, W Midlands, England.
[Ormerod, Thomas C.] Univ Sussex, Sch Psychol, Falmer, E Sussex, England.
RP Mattison, MLA (reprint author), Univ Chester, Dept Psychol, Chester CH1 4BJ, Cheshire, England.
EM m.mattison@chester.ac.uk
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NR 60
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1751
EP 1765
DI 10.1007/s10803-014-2335-z
PG 15
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700020
PM 25503484
ER
PT J
AU Idring, S
Lundberg, M
Sturm, H
Dalman, C
Gumpert, C
Rai, D
Lee, BK
Magnusson, C
AF Idring, Selma
Lundberg, Michael
Sturm, Harald
Dalman, Christina
Gumpert, Clara
Rai, Dheeraj
Lee, Brian K.
Magnusson, Cecilia
TI Changes in Prevalence of Autism Spectrum Disorders in 2001-2011:
Findings from the Stockholm Youth Cohort
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Intellectual disability; Prevalence; Time
trend; Stockholm; Sweden
ID RISK-FACTORS; SOCIOECONOMIC-STATUS; COMPREHENSIVE METAANALYSIS;
PERINATAL FACTORS; ASPERGER SYNDROME; POPULATION; CHILDREN; ETHNICITY;
DIAGNOSIS; EPIDEMIOLOGY
AB In a record-linkage study in Stockholm, Sweden, the year 2011 prevalence of diagnosed autism spectrum disorders (ASD) was found to be 0.40, 1.74, 2.46, and 1.76 % among 0-5, 6-12, 13-17, and 18-27 year olds, respectively. The corresponding proportion of cases with a recorded diagnosis of intellectual disability was 17.4, 22.1, 26.1 and 29.4 %. Between 2001 and 2011, ASD prevalence increased almost 3.5 fold among children aged 2-17 years. The increase was mainly accounted for by an eightfold increase of ASD without intellectual disability (from 0.14 to 1.10 %), while the prevalence of ASD with intellectual disability increased only slightly (from 0.28 to 0.34 %). The increase in ASD prevalence is likely contributed to by extrinsic factors such as increased awareness and diagnostics.
C1 [Idring, Selma; Lundberg, Michael; Dalman, Christina; Rai, Dheeraj; Magnusson, Cecilia] Karolinska Inst, Dept Publ Hlth Sci, S-17177 Stockholm, Sweden.
[Idring, Selma; Sturm, Harald] Stockholm Cty Council, Neurodev Psychiat Unit Southeast Child & Youth Ps, Stockholm, Sweden.
[Dalman, Christina; Magnusson, Cecilia] Stockholm Cty Council, Ctr Epidemiol & Community Med, Stockholm, Sweden.
[Gumpert, Clara] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
[Rai, Dheeraj] Univ Bristol, Sch Social & Community Med, Acad Unit Psychiat, Bristol, Avon, England.
[Rai, Dheeraj] Avon & Wiltshire Partnership NHS Mental Hlth Trus, Bristol, Avon, England.
[Lee, Brian K.] Drexel Univ, AJ Drexel Autism Inst, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.
RP Idring, S (reprint author), Karolinska Inst, Dept Publ Hlth Sci, Widerstromska Huset,Tomtebodavagen 18A, S-17177 Stockholm, Sweden.
EM Selma.idring@ki.se
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
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World Health Organization, 2005, INT STAT CLASS DIS R
World Health Organization, 1977, 9 REV C 1975 AD 29 W, V1
NR 55
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1766
EP 1773
DI 10.1007/s10803-014-2336-y
PG 8
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700021
PM 25475364
ER
PT J
AU Evers, K
Steyaert, J
Noens, I
Wagemans, J
AF Evers, Kris
Steyaert, Jean
Noens, Ilse
Wagemans, Johan
TI Reduced Recognition of Dynamic Facial Emotional Expressions and
Emotion-Specific Response Bias in Children with an Autism Spectrum
Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder (ASD); Dynamic facial expressions; Emotion
recognition; Face perception; Response bias; Theory of mind
ID 1ST-DEGREE RELATIVES; PERCEPTION; INDIVIDUALS; PHENOTYPE; INTENSITIES;
CHILDHOOD; DISPLAYS; DEFICITS; PARENTS; ADULTS
AB Emotion labelling was evaluated in two matched samples of 6-14-year old children with and without an autism spectrum disorder (ASD; N = 45 and N = 50, resp.), using six dynamic facial expressions. The Emotion Recognition Task proved to be valuable demonstrating subtle emotion recognition difficulties in ASD, as we showed a general poorer emotion recognition performance, in addition to some emotion-specific impairments in the ASD group. Participants' preference for selecting a certain emotion label, irrespective of the stimulus presented, played an important role in our results: response bias-corrected data still showed an overall decreased emotion recognition performance in ASD, but no emotion-specific impairments anymore. Moreover, ASD traits and empathy were correlated with emotion recognition performance.
C1 [Evers, Kris; Wagemans, Johan] Katholieke Univ Leuven, Expt Psychol Lab, B-3000 Leuven, Belgium.
[Evers, Kris; Steyaert, Jean] UPC KU Leuven, Dept Child Psychiat, Leuven, Belgium.
[Evers, Kris; Steyaert, Jean; Noens, Ilse; Wagemans, Johan] Katholieke Univ Leuven, Leuven Autism Res LAuRes, Leuven, Belgium.
[Steyaert, Jean] Univ Hosp Maastricht, Dept Clin Genet, Maastricht, Netherlands.
[Noens, Ilse] Katholieke Univ Leuven, Parenting & Special Educ Res Unit, Leuven, Belgium.
[Noens, Ilse] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
RP Evers, K (reprint author), Katholieke Univ Leuven, Expt Psychol Lab, Tiensestr 102,Box 3711, B-3000 Leuven, Belgium.
EM kris.evers@ppw.kuleuven.be
FU Methusalem program by Flemish Government [METH 08/02]; Research Council
of the KU Leuven [IDO/080/013]; Marguerite Marie Delacroix Support Fund
[GV/B-141]
FX We want to thank all participating children and their parents. Special
thanks go to the participating schools, Ten Bunderen (Moorslede), De
Puzzel (Kleine-Brogel) and De Schommel (Lommel). Thanks to Dr. Ervin
Poljac for sharing his expertise with the Emotion Recognition Task. We
thank Birgitt Haesen and the following master students for their
assistance with data collection: Nele Berghmans, Stephanie Deckmyn,
Sanne Drees, Tine Herreman, Ellen Janssen, Loes Steegmans, Lotte van
Esch, Alysee Van Laeken, and Leen Vercammen. This research was funded by
the Methusalem program by the Flemish Government (METH 08/02) awarded to
J.W., by a grant from the Research Council of the KU Leuven
(IDO/080/013) awarded to J.S., J.W. and I.N., and by a grant from the
Marguerite Marie Delacroix Support Fund (GV/B-141) awarded to K.E.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 44
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1774
EP 1784
DI 10.1007/s10803-014-2337-x
PG 11
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700022
PM 25563453
ER
PT J
AU Brosnan, M
Johnson, H
Grawmeyer, B
Chapman, E
Benton, L
AF Brosnan, Mark
Johnson, Hilary
Grawmeyer, Beate
Chapman, Emma
Benton, Laura
TI Emotion Recognition in Animated Compared to Human Stimuli in Adolescents
with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Emotion recognition; Multimodal; Animated
cartoon stimuli
ID HIGH-FUNCTIONING AUTISM; FACIAL EXPRESSIONS; ASPERGERS-SYNDROME;
INDIVIDUALS; ADULTS; PERCEPTION; FACES; INTENSITIES; EXTRACTION;
SYMPTOMS
AB There is equivocal evidence as to whether there is a deficit in recognising emotional expressions in Autism spectrum disorder (ASD). This study compared emotion recognition in ASD in three types of emotion expression media (still image, dynamic image, auditory) across human stimuli (e.g. photo of a human face) and animated stimuli (e.g. cartoon face). Participants were 37 adolescents (age 11-16) with a diagnosis of ASD (33 male, 4 female). 42 males and 39 females served as typically developing, age-matched controls. Overall there was significant advantage for control groups over the ASD group for emotion recognition in human stimuli but not animated stimuli, across modalities. For static animated images specifically, those with ASD significantly outperformed controls. The findings are consistent with the ASD group using atypical explicit strategies.
C1 [Brosnan, Mark; Johnson, Hilary; Chapman, Emma] Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England.
[Grawmeyer, Beate] Univ London, Birkbeck Coll, London Knowledge Lab, London WC1N 3QS, England.
[Benton, Laura] Univ London, Inst Educ, London Knowledge Lab, London WC1N 3QS, England.
RP Brosnan, M (reprint author), Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England.
EM M.J.Brosnan@Bath.ac.uk
FU EPSRC [EP/G031975/1]
FX Grant sponsor EPSRC; Grant Number EP/G031975/1.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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Widen SC, 2003, DEV PSYCHOL, V39, P114, DOI 10.1037//0012-1649.39.1.114
World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 55
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1785
EP 1796
DI 10.1007/s10803-014-2338-9
PG 12
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700023
PM 25567528
ER
PT J
AU Khowaja, MK
Hazzard, AP
Robins, DL
AF Khowaja, Meena K.
Hazzard, Ann P.
Robins, Diana L.
TI Sociodemographic Barriers to Early Detection of Autism: Screening and
Evaluation Using the M-CHAT, M-CHAT-R, and Follow-Up
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Screening; Disparities; Socioeconomic status; Maternal education; Race;
Autism
ID PERVASIVE DEVELOPMENTAL DISORDERS; FUNCTIONAL HEALTH LITERACY; SPECTRUM
DISORDERS; MODIFIED CHECKLIST; CHRONIC DISEASE; UNITED-STATES; CHILDREN;
KNOWLEDGE; DIAGNOSIS; DISPARITIES
AB Parents (n = 11,845) completed the Modified Checklist for Autism in Toddlers (or its latest revision) at pediatric visits. Using sociodemographic predictors of maternal education and race, binary logistic regressions were utilized to examine differences in autism screening, diagnostic evaluation participation rates and outcomes, and reasons for non-participation. Families of lower maternal education and racial minorities exhibited inflated initial screen positive rates and lower participation at Follow-Up, although not at the evaluation. Economic challenges, such as invalid phone numbers, were identified as barriers to reaching these families. Families of higher education and White race were more likely to decline participation in evaluation. Results suggest the need for increased public education about childhood development to enhance awareness, reduce stigma, and streamline screening.
C1 [Khowaja, Meena K.] Georgia State Univ, Dept Psychol, Atlanta, GA 30302 USA.
[Hazzard, Ann P.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30303 USA.
[Robins, Diana L.] Drexel Univ, AJ Drexel Autism Inst, Philadelphia, PA 19104 USA.
RP Khowaja, MK (reprint author), Georgia State Univ, Dept Psychol, POB 5010, Atlanta, GA 30302 USA.
EM mkhowaja1@student.gsu.edu
FU Centers for Disease Control Prevention; Georgia State University; Eunice
Kennedy Shriver National Institute for Child Health and Human
Development [R01HD039961]
FX We would like to thank our financial support sources, a joint Centers
for Disease Control & Prevention and Georgia State University seed
grant, as well as a research grant from the Eunice Kennedy Shriver
National Institute for Child Health and Human Development, R01HD039961.
Statistical consultation was provided by Lucy Robinson, Ph.D. (Drexel
University) and Wing Yi Chan, Ph.D. (Georgia State University). We would
also like to acknowledge the families who participated in the study, as
well as the pediatricians who assisted by offering the M-CHAT(-R)
questionnaire to their patients. Additionally, we are grateful for the
time and effort put forth by the Developmental Neuropsychology Lab
research staff involved in data collection for the project at Georgia
State University. Data presented in the manuscript are a subset of a
larger ongoing research study. Preliminary findings from the research
presented in the enclosed manuscript were presented at a regional and
international meeting, and have not been published elsewhere.
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NR 67
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1797
EP 1808
DI 10.1007/s10803-014-2339-8
PG 12
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700024
PM 25488122
ER
PT J
AU Kamps, D
Thiemann-Bourque, K
Heitzman-Powell, L
Schwartz, I
Rosenberg, N
Mason, R
Cox, S
AF Kamps, Debra
Thiemann-Bourque, Kathy
Heitzman-Powell, Linda
Schwartz, Ilene
Rosenberg, Nancy
Mason, Rose
Cox, Suzanne
TI A Comprehensive Peer Network Intervention to Improve Social
Communication of Children with Autism Spectrum Disorders: A Randomized
Trial in Kindergarten and First Grade
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Peer networks; Social-communication skills; Text cues
ID HIGH-FUNCTIONING CHILDREN; SKILLS INTERVENTIONS; YOUNG-CHILDREN;
STUDENTS; RECOMMENDATIONS; ADOLESCENTS; INITIATIONS; SETTINGS; SCRIPTS;
CUES
AB The purpose of this randomized control group study was to examine the effects of a peer network intervention that included peer mediation and direct instruction for Kindergarten and First-grade children with autism spectrum disorders. Trained school staff members provided direct instruction for 56 children in the intervention group, and 39 children participated in a comparison group. Results showed children in the intervention group displayed significantly more initiations to peers than did the comparison group during non-treatment social probes and generalization probes. Treatment session data showed significant growth for total communications over baseline levels. Children in treatment also showed more growth in language and adaptive communication. Finally, teachers' ratings of prosocial skills revealed significantly greater improvements for the intervention group.
C1 [Kamps, Debra; Thiemann-Bourque, Kathy; Cox, Suzanne] Univ Kansas, Juniper Gardens Childrens Project, Life Span Inst, Kansas City, KS 66101 USA.
[Heitzman-Powell, Linda] Univ Kansas, Med Ctr, Kansas City, KS 66101 USA.
[Schwartz, Ilene; Rosenberg, Nancy] Univ Washington, Dept Special Educ, Seattle, WA 98195 USA.
[Mason, Rose] Univ Kansas, Kansas City, KS 66101 USA.
RP Kamps, D (reprint author), Univ Kansas, Juniper Gardens Childrens Project, Life Span Inst, 444 Minnesota Ave,3rd Floor, Kansas City, KS 66101 USA.
EM dkamps@ku.edu; thiemann@ku.edu; lhpowell@ku.edu; ilene@u.washington.edu;
nancy@u.washington.edu; rmason519@ku.edu; scox@ku.edu
FU Institute of Education Sciences, Department of Education [R324A090091]
FX The research was funded by the Institute of Education Sciences,
Department of Education (R324A090091). Opinions expressed herein are
those of the authors and do not necessarily reflect the position of the
funding agency. We gratefully acknowledge our graduate research
assistants: Marissa Congdon, Sarah Feldmiller, Shane Herriot, Emily
Kroman, Alison Marti, Brandon McFadden, Todd Miller, Lindsay Myatich,
and Veronica Pamparo, and research assistants: Tonya Evans and Amy
Turcotte, for their assistance in consultation with school staff and
data collection; and the participating teachers, students, and families
for their time and ongoing support.
CR Agresti A., 2002, CATEGORICAL DATA ANA
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NR 55
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1809
EP 1824
DI 10.1007/s10803-014-2340-2
PG 16
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700025
PM 25510450
ER
PT J
AU Bitsika, V
Sharpley, CF
AF Bitsika, Vicki
Sharpley, Christopher F.
TI Variation in the Profile of Anxiety Disorders in Boys with an ASD
According to Method and Source of Assessment
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ASD; Anxiety; Assessment; Parent
ID AUTISM SPECTRUM DISORDERS; PSYCHIATRIC-DISORDERS; ASPERGER-SYNDROME;
CHILDREN; ADOLESCENTS; SYMPTOMS; YOUTH; COMORBIDITY; AGREEMENT
AB To determine any variation that might occur due to the type of assessment and source used to assess them, the prevalence of 7 anxiety disorders were investigated in a sample of 140 boys with an Autism spectrum disorder (ASD) and 50 non-ASD (NASD) boys via the Child and Adolescent Symptom Inventory and the KIDSCID Clinical Interview. Boys with an ASD were significantly more anxious than their NASD peers. Data collected from the boys with an ASD themselves showed differences in the severity and diagnostic criterion of anxiety disorders to data collected from the boys' parents. There were age-related variations to the pattern of anxiety disorder differences across reports from the boys with an ASD and reports from their parents.
C1 [Bitsika, Vicki; Sharpley, Christopher F.] Bond Univ, Ctr Autism Spectrum Disorders, Robina, Qld 4229, Australia.
[Sharpley, Christopher F.] Univ New England, Brain Behav Res Grp, Sch Sci & Technol, Armidale, NSW 2351, Australia.
RP Sharpley, CF (reprint author), Univ New England, Brain Behav Res Grp, Sch Sci & Technol, Armidale, NSW 2351, Australia.
EM csharpley@onthenet.com.au
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NR 32
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1825
EP 1835
DI 10.1007/s10803-014-2343-z
PG 11
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700026
PM 25503485
ER
PT J
AU Boets, B
Verhoeven, J
Wouters, J
Steyaert, J
AF Boets, Bart
Verhoeven, Judith
Wouters, Jan
Steyaert, Jean
TI Fragile Spectral and Temporal Auditory Processing in Adolescents with
Autism Spectrum Disorder and Early Language Delay
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Auditory processing; Hemispheric
lateralization; Spectral; Temporal; Pitch
ID EVENT-RELATED POTENTIALS; SPEECH-PERCEPTION; ASPERGER-SYNDROME; PITCH
DISCRIMINATION; ABSOLUTE PITCH; HEMISPHERIC-SPECIALIZATION; MISMATCH
NEGATIVITY; PRESCHOOL-CHILDREN; EVOKED POTENTIALS; CENTRAL COHERENCE
AB We investigated low-level auditory spectral and temporal processing in adolescents with autism spectrum disorder (ASD) and early language delay compared to matched typically developing controls. Auditory measures were designed to target right versus left auditory cortex processing (i.e. frequency discrimination and slow amplitude modulation (AM) detection versus gap-in-noise detection and faster AM detection), and to pinpoint the task and stimulus characteristics underlying putative superior spectral processing in ASD. We observed impaired frequency discrimination in the ASD group and suggestive evidence of poorer temporal resolution as indexed by gap-in-noise detection thresholds. These findings question the evidence of enhanced spectral sensitivity in ASD and do not support the hypothesis of superior right and inferior left hemispheric auditory processing in ASD.
C1 [Boets, Bart; Steyaert, Jean] Univ Leuven KU Leuven, Dept Neurosci, Child & Adolescent Psychiat, B-3000 Leuven, Belgium.
[Boets, Bart] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Boets, Bart; Verhoeven, Judith; Steyaert, Jean] Univ Leuven KU Leuven, Leuven Autism Res LAuRes, B-3000 Leuven, Belgium.
[Verhoeven, Judith] Kempenhaeghe, Dept Epilepsy, NL-5590 AB Heeze, Netherlands.
[Wouters, Jan] Univ Leuven KU Leuven, Dept Neurosci, ExpORL, B-3000 Leuven, Belgium.
RP Boets, B (reprint author), Univ Leuven KU Leuven, Dept Neurosci, Child & Adolescent Psychiat, Herestr 49,Box 7003, B-3000 Leuven, Belgium.
EM bart.boets@med.kuleuven.be
FU Research Council of KU Leuven [IDO/08/013]
FX Bart Boets is a post-doctoral research fellow of the Research Foundation
Flanders and a Fulbright Visiting Scholar. The research was financed by
a grant from the Research Council of KU Leuven (IDO/08/013). We thank
Heleen Luts, Thea Van Werde and Loes Verber for assistance with testing,
and all participating children and their families for their time and
effort.
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NR 109
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1845
EP 1857
DI 10.1007/s10803-014-2341-1
PG 13
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700028
PM 25503681
ER
PT J
AU Smith, IM
Flanagan, HE
Garon, N
Bryson, SE
AF Smith, Isabel M.
Flanagan, Helen E.
Garon, Nancy
Bryson, Susan E.
TI Effectiveness of Community-Based Early Intervention Based on Pivotal
Response Treatment
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Early intervention; Pivotal Response Treatment
ID INTENSIVE BEHAVIORAL INTERVENTION; AUTISM SPECTRUM DISORDERS; SOCIAL
RESPONSIVENESS SCALE; PRESCHOOL-CHILDREN; VERBAL-BEHAVIOR; FOLLOW-UP;
PROGRAM; OUTCOMES; PARENTS
AB Preschoolers (n = 118) with autism spectrum disorder (ASD) participated in this prospective effectiveness study of an early intervention program. Treatment entailed parent training and therapist-implemented components, incorporating Pivotal Response Treatment and Positive Behaviour Support. Standardized ability and behavioural measures were gathered prior to and following the 1-year intervention. Analyses were conducted for three groups based on baseline IQ: Higher IQ (a parts per thousand yen70; n = 36), Moderately Low IQ (40-69; n = 40), and Very Low IQ (< 40, n = 42). Observed gains in key language and cognitive outcomes were significant for all groups. Baseline cognitive scores significantly predicted 1-year outcomes. Results are encouraging for this relatively low-intensity community-based intervention program.
C1 [Smith, Isabel M.; Bryson, Susan E.] Dalhousie Univ, Dept Pediat, Halifax, NS, Canada.
[Smith, Isabel M.; Bryson, Susan E.] Dalhousie Univ, Dept Psychol & Neurosci, Halifax, NS, Canada.
[Smith, Isabel M.; Flanagan, Helen E.; Bryson, Susan E.] IWK Hlth Ctr, Autism Res Ctr, Halifax, NS, Canada.
[Flanagan, Helen E.] IWK Hlth Ctr, EIBI Program, Halifax, NS, Canada.
[Garon, Nancy] Mt Allison Univ, Dept Psychol, Sackville, NB E0A 3C0, Canada.
RP Smith, IM (reprint author), IWK Hlth Ctr, Autism Res Ctr, POB 9700, Halifax, NS, Canada.
EM isabel.smith@iwk.nshealth.ca
FU Canadian Institutes of Health Research; Nova Scotia Health Research
Foundation; Dalhousie University Faculty of Medicine; Autism Research at
Dalhousie University/IWK Health Centre
FX This research was supported by grants from the Canadian Institutes of
Health Research, and the Nova Scotia Health Research Foundation. Dr.
Smith was supported by a Clinical Research Scholar Award from the
Dalhousie University Faculty of Medicine, and now holds the Craig Chair
in Autism Research at Dalhousie University/IWK Health Centre. At the
time the study took place, Dr. Bryson held the Craig Chair in Autism
Research. We are grateful to the families who participated in this
study, to the clinical teams responsible for the intervention,
especially Dr. Dorothy Chitty, and to Ms. Patricia Murray of the Nova
Scotia Department of Health and Wellness, who has championed this
research program. We also thank the staff and students of the IWK Autism
Research Centre for their roles in data collection. Portions of this
study were presented at the International Meeting for Autism Research in
May, 2012.
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NR 60
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1858
EP 1872
DI 10.1007/s10803-014-2345-x
PG 15
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700029
PM 25563454
ER
PT J
AU Bottema-Beutel, K
Li, ZS
AF Bottema-Beutel, Kristen
Li, Zhushan
TI Adolescent Judgments and Reasoning About the Failure to Include Peers
with Social Disabilities
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Inclusion; Moral reasoning; Domain theory;
Adolescents
ID EDUCATIONAL INTERVENTION; AMERICAN CHILDRENS; MAINSTREAM SCHOOL; AUTISM;
EXCLUSION; INCLUSION; STUDENTS; CONTACT; ASD
AB Adolescents with autism spectrum disorder often do not have access to crucial peer social activities. This study examines how typically developing adolescents evaluate decisions not to include a peer based on disability status, and the justifications they apply to these decisions. A clinical interview methodology was used to elicit judgments and justifications across four contexts. We found adolescents are more likely to judge the failure to include as acceptable in personal as compared to public contexts. Using logistic regression, we found that adolescents are more likely to provide moral justifications as to why failure to include is acceptable in a classroom as compared to home, lab group, and soccer practice contexts. Implications for intervention are also discussed.
C1 [Bottema-Beutel, Kristen] Boston Coll, Lynch Sch Educ, Dept Teacher Educ Special Educ & Curriculum & Ins, Chestnut Hill, MA 02467 USA.
[Li, Zhushan] Boston Coll, Lynch Sch Educ, Dept Educ Res Measurement & Evaluat, Chestnut Hill, MA 02467 USA.
RP Bottema-Beutel, K (reprint author), Boston Coll, Lynch Sch Educ, Dept Teacher Educ Special Educ & Curriculum & Ins, 140 Commonwealth Ave, Chestnut Hill, MA 02467 USA.
EM kristen.bottema-beutel@bc.edu
FU IES [R324B080005]; OSEP [H325D060036]
FX The first author received partial support in writing this manuscript
from IES Grant No. R324B080005 and OSEP Grant No. H325D060036. We would
like to thank the adolescents that participated in this research, Rose
Cartwright and Christina Jones for their diligent work on this project,
Jennifer Gilbert for statistical consultation, and Elliot Turiel for
comments on an earlier draft of this manuscript. We would also like to
thank the anonymous reviewers for their helpful feedback.
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NR 51
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1873
EP 1886
DI 10.1007/s10803-014-2348-7
PG 14
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700030
PM 25575622
ER
PT J
AU Fitch, A
Fein, DA
Eigsti, IM
AF Fitch, Allison
Fein, Deborah A.
Eigsti, Inge-Marie
TI Detail and Gestalt Focus in Individuals with Optimal Outcomes from
Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Pragmatic language; Global/local bias; Weak central coherence; Optimal
outcomes; Executive function
ID HIGH-FUNCTIONING CHILDREN; DISCOURSE COHERENCE; LANGUAGE DEFICITS; WEAK
COHERENCE; 2 THINGS; HISTORY; ADOLESCENTS; INTERFERENCE; PERCEPTION;
CONTEXT
AB Individuals with high-functioning autism (HFA) have a cognitive style that privileges local over global or gestalt details. While not a core symptom of autism, individuals with HFA seem to reliably show this bias. Our lab has been studying a sample of children who have overcome their early ASD diagnoses, showing "optimal outcomes" (OO). This study characterizes performance by OO, HFA, and typically developing (TD) adolescents as they describe paintings under cognitive load. Analyses of detail focus in painting descriptions indicated that the HFA group displayed significantly more local focus than both OO and TD groups, while the OO and TD groups did not differ. We discuss implications for the centrality of detail focus to the autism diagnosis.
C1 [Fitch, Allison; Fein, Deborah A.; Eigsti, Inge-Marie] Univ Connecticut, Coll Liberal Arts & Sci, Dept Psychol, Storrs, CT 06269 USA.
RP Eigsti, IM (reprint author), Univ Connecticut, Coll Liberal Arts & Sci, Dept Psychol, 406 Babbidge Rd,U-1020, Storrs, CT 06269 USA.
EM inge-marie.eigsti@uconn.edu
FU National Institutes of Mental Health [R01 MH076189]
FX We gratefully acknowledge funding from R01 MH076189 to DF from the
National Institutes of Mental Health and the time and effort of
participating families and children.
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NR 48
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1887
EP 1896
DI 10.1007/s10803-014-2347-8
PG 10
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700031
PM 25563455
ER
PT J
AU Falck-Ytter, T
Thorup, E
Bolte, S
AF Falck-Ytter, Terje
Thorup, Emilia
Bolte, Sven
TI Brief Report: Lack of Processing Bias for the Objects Other People
Attend to in 3-Year-Olds with Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Communication; Development; Cognition; Neurodevelopmental disorders;
Vision
ID JOINT VISUAL-ATTENTION; SPECTRUM DISORDER; EYE-MOVEMENTS; GAZE;
CHILDREN; INFANTS; RISK; MICROSTRUCTURE; DEFICITS; TRACKING
AB Whether gaze following-a key component of joint attention-is impaired in children with autism spectrum disorder (ASD) is currently debated. Functional gaze following involves saccading towards the attended rather than unattended targets (accuracy) as well as a subsequent processing bias for attended objects. Using non-invasive eye tracking technology, we show that gaze following accuracy is intact in intellectually low-functioning 3-year-olds with ASD. However, analyses of the duration of first fixations at the objects in the scene revealed markedly weaker initial processing bias for attended objects in children with ASD compared to children with typical development and non-autistic children with developmental delays. Limited processing bias for the objects other people attend to may negatively affect learning opportunities in ASD.
C1 [Falck-Ytter, Terje; Bolte, Sven] Karolinska Inst, Child & Adolescent Psychiat Res Ctr, Karolinska Inst KIND,Dept Womens & Childrens Hlth, Pediat Neuropsychiat Unit,Ctr Neurodev Disorders, S-11330 Stockholm, Sweden.
[Falck-Ytter, Terje; Thorup, Emilia] Uppsala Univ, Dept Psychol, Uppsala Child & Babylab, S-75142 Uppsala, Sweden.
[Bolte, Sven] Stockholm Cty Council, Div Child & Adolescent Psychiat, Stockholm, Sweden.
RP Thorup, E (reprint author), Uppsala Univ, Dept Psychol, Uppsala Child & Babylab, S-75142 Uppsala, Sweden.
EM emilia.thorup@psyk.uu.se
FU Swedish Research Council; FAS; FORMAS; VINNOVA [259-2012-24]; ESF COST
Action [BM1004]; Bank of Sweden Tercentenary Foundation [P12-0270:1,
P10-078]; Swedish Research Council [523-2009-7054]
FX We are thankful to Erik Rehnberg for invaluable help during data
collection. This research was supported by a grant to SB and TFY from
the Swedish Research Council in partnership with FAS, FORMAS, and
VINNOVA (Crossdisciplinary research programme concerning children's and
young people's mental health; grant number 259-2012-24). The work of all
authors was supported by the ESF COST Action BM1004 'Enhancing the
Scientific Study of Early Autism' (ESSEA). TFY and SB were supported by
The Bank of Sweden Tercentenary Foundation [P12-0270:1 and P10-078,
respectively]. SB was supported by the Swedish Research Council [Nr.
523-2009-7054].
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NR 31
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1897
EP 1904
DI 10.1007/s10803-014-2278-4
PG 8
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700032
PM 25331324
ER
PT J
AU Karten, A
Hirsch, J
AF Karten, Ariel
Hirsch, Joy
TI Brief Report: Anomalous Neural Deactivations and Functional Connectivity
During Receptive Language in Autism Spectrum Disorder: A Functional MRI
Study
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Functional magnetic resonance imaging (fMRI); Functional connectivity;
Psychophysiological interactions (PPI); Negative BOLD response (NBR);
Neural inhibition; Autism; Receptive language processing
ID NEGATIVE BOLD; HUMAN BRAIN; DEFAULT NETWORK; FMRI; CORTEX; DYSFUNCTION;
SPEECH; EXCITATION/INHIBITION; STIMULATION; INHIBITION
AB Neural mechanisms that underlie language disability in autism spectrum disorder (ASD) have been associated with reduced excitatory processes observed as positive blood oxygen level dependent (BOLD) responses. However, negative BOLD responses (NBR) associated with language and inhibitory processes have been less studied in ASD. In this study, functional magnetic resonance imaging showed that the NBR in ASD participants was reduced during passive listening to spoken narratives compared to control participants. Further, functional connectivity between the superior temporal gyrus and regions that exhibited a NBR during receptive language in control participants was increased in ASD participants. These findings extend models for receptive language disability in ASD to include anomalous neural deactivations and connectivity consistent with reduced or poorly modulated inhibitory processes.
C1 [Karten, Ariel; Hirsch, Joy] Yale Univ, Sch Med, Dept Psychiat, Brain Funct Lab, New Haven, CT 06511 USA.
[Karten, Ariel; Hirsch, Joy] Yale Univ, Sch Med, Dept Neurobiol, Brain Funct Lab, New Haven, CT 06511 USA.
[Karten, Ariel] SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA.
[Hirsch, Joy] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA.
[Hirsch, Joy] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06511 USA.
RP Hirsch, J (reprint author), Yale Univ, Sch Med, Dept Psychiat, 300 George St,Suite 902, New Haven, CT 06511 USA.
EM joy.hirsch@yale.edu
FU Gatsby Initiative in Brain Circuitry [GAT 2742]; US Army RDECOM-TARDEC
[W56H2 V-04-P-L]; NIH [RO1NS0 56274]
FX Authors are grateful for significant contributions by students and
subjects who have participated in the development of this project,
including Grace Lai (Columbia University Graduate Program in
Neuroscience) and Spiro Pantazatos (Columbia University Graduate Program
in Physiology and Cellular Biophysics), and for mentoring guidance, Jay
Edelman (The City College of College [A.K]). Funding for this project
includes a Grant from the Gatsby Initiative in Brain Circuitry, GAT 2742
(GL); US Army RDECOM-TARDEC W56H2 V-04-P-L (J.H); and NIH RO1NS0 56274
(sub-contract to J.H, PI Nicholas Schiff).
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NR 43
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1905
EP 1914
DI 10.1007/s10803-014-2344-y
PG 10
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700033
PM 25526952
ER
PT J
AU Vierck, E
Silverman, JM
AF Vierck, Esther
Silverman, Jeremy M.
TI Brief Report: Phenotypic Differences and their Relationship to Paternal
Age and Gender in Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; De novo mutations; Paternal age; Phenotype; Maternal age
ID PERVASIVE DEVELOPMENTAL DISORDERS; DE-NOVO MUTATIONS; SEX-DIFFERENCES;
RISK-FACTORS; PSYCHIATRIC-DISORDERS; FUNCTIONAL IMPACT;
INFANTILE-AUTISM; TWIN; LINKAGE; REARRANGEMENTS
AB Two modes of inheritance have been proposed in autism spectrum disorder, transmission though pre-existing variants and de novo mutations. Different modes may lead to different symptom expressions in affected individuals. De novo mutations become more likely with advancing paternal age suggesting that paternal age may predict phenotypic differences. To test this possibility we measured IQ, adaptive behavior, and autistic symptoms in 830 probands from simplex families. We conducted multiple linear regression analysis to estimate the predictive value of paternal age, maternal age, and gender on behavioral measures and IQ. We found a differential effect of parental age and sex on repetitive and restricted behaviors. Findings suggest effects of paternal age on phenotypic differences in simplex families with ASD.
C1 [Vierck, Esther] Univ Otago, Dept Psychol Med, Christchurch 8140, New Zealand.
[Silverman, Jeremy M.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
RP Vierck, E (reprint author), Univ Otago, Dept Psychol Med, BO Box 4345, Christchurch 8140, New Zealand.
EM esther.vierck@otago.ac.nz
FU Seaver Foundation
FX We thank the Autism Genome Project (AGP) for their generosity in
allowing us to use their data and their helpful suggestions. We also
like to thank Jim Smeidler (Mount Sinai School of Medicine, New York,
USA) for his help with the analysis. The research received support from
the Seaver Foundation.
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NR 72
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD JUN
PY 2015
VL 45
IS 6
BP 1915
EP 1924
DI 10.1007/s10803-014-2346-9
PG 10
WC Psychology, Developmental
SC Psychology
GA CI7XC
UT WOS:000354977700034
PM 25526953
ER
PT J
AU van Steensel, FJA
Bogels, SM
AF van Steensel, F. J. A.
Bogels, S. M.
TI CBT for Anxiety Disorders in Children With and Without Autism Spectrum
Disorders
SO JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
LA English
DT Article
DE CBT; anxiety; ASD; children
ID COGNITIVE-BEHAVIORAL THERAPY; HIGH-FUNCTIONING AUTISM; RANDOMIZED
CONTROLLED-TRIAL; DIAGNOSTIC INTERVIEW; ADOLESCENTS; INTERVENTION;
METAANALYSIS; SCHEDULE; EFFICACY; EUROQOL
AB Objective: The effectiveness of cognitive-behavioral therapy (CBT) for anxiety disorders in children with autism spectrum disorders (ASD) was examined, and compared with children without ASD. Method: Children with ASD and comorbid anxiety disorders (n = 79, 58 boys; M-age = 11.76) and children with anxiety disorders (n = 95, 46 boys; M-age = 12.85), and their parents, participated. All families were referred to 1 of 7 mental health care centers and received the same CBT. Anxiety, quality of life, ASD-like behaviors, and emotional-behavioral problems were measured at waitlist (ASD-group only, n = 17), pretest, posttest, and 3 months, 1 year, and 2 years after CBT. Results: CBT was more effective than waitlist for treating anxiety disorders (d = -1.45) and anxiety symptoms (d = -0.48) in children with ASD. At 2 years follow-up, 61% of the children with and 64% without ASD were free of their primary anxiety disorder (percentages not significantly different). The decrease in severity of anxiety disorders after CBT (d values ranging between -1.05 and -1.46) was not different for children with and without ASD. Improvements were less in children with ASD for (only) 2 out of 7 continuous outcomes measures: anxiety symptoms (d values ranging between -0.68 and -0.94 vs. d values ranging between -0.98 and -1.25) and quality of life (d values ranging between 0.39 and 0.56 vs. d values ranging between 0.77 and 0.98). Conclusions: CBT for anxiety disorders is effective for children with ASD, also in the long-term. Treatment gains may be somewhat less compared with children without ASD.
C1 [van Steensel, F. J. A.; Bogels, S. M.] Univ Amsterdam, Child Dev & Educ, NL-1018 WS Amsterdam, Netherlands.
RP van Steensel, FJA (reprint author), Univ Amsterdam, Child Dev & Educ, Res Prior Area Yield, Nieuwe Achtergracht 127, NL-1018 WS Amsterdam, Netherlands.
EM f.j.a.vansteensel@uva.nl
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NR 38
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0022-006X
EI 1939-2117
J9 J CONSULT CLIN PSYCH
JI J. Consult. Clin. Psychol.
PD JUN
PY 2015
VL 83
IS 3
BP 512
EP 523
DI 10.1037/a0039108
PG 12
WC Psychology, Clinical
SC Psychology
GA CJ0LK
UT WOS:000355167300008
PM 25894668
ER
PT J
AU Kasari, C
Gulsrud, A
Paparella, T
Hellemann, G
Berry, K
AF Kasari, Connie
Gulsrud, Amanda
Paparella, Tanya
Hellemann, Gerhard
Berry, Kathleen
TI Randomized Comparative Efficacy Study of Parent-Mediated Interventions
for Toddlers With Autism
SO JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
LA English
DT Article
DE autism toddlers; early intervention; parent training; JASPER; parenting
stress
ID JOINT ATTENTION INTERVENTION; CONTROLLED-TRIAL; YOUNG-CHILDREN; SPECTRUM
DISORDERS; PRESCHOOL-CHILDREN; CLINICAL-TRIAL; MENTAL-HEALTH; COUNT
DATA; FOLLOW-UP; PLAY
AB Objective: This study compared effects of two parent-mediated interventions on joint engagement outcomes as augmentations of an early intervention program for toddlers with autism spectrum disorder (ASD). Method: Participants included 86 toddlers (range 22-36 months) with ASD and their primary caregiver. Caregiver-child dyads were randomized to receive 10 weeks of hands-on parent training in a naturalistic, developmental behavioral intervention (joint attention, symbolic play, engagement and regulation-JASPER) or a parent-only psychoeducational intervention (PEI). Dose was controlled in terms of researcher-parent contact and early intervention services received by the child. Results: Results yielded significant effects of the JASPER intervention on the primary outcome of joint engagement. The treatment effect was large (Cohen's f(2) = .69) and maintained over the 6-month follow-up. JASPER effects were also found on secondary outcomes of play diversity, highest play level achieved, and generalization to the child's classroom for child-initiated joint engagement. The PEI intervention was found to be effective in reducing parenting stress associated with child characteristics. All secondary effects were generally small to moderate. Conclusions: These data highlight the benefit of a brief, targeted, parent-mediated intervention on child outcomes. Future studies may consider the combination of JASPER and PEI treatments for optimal parent and child outcomes. Trial registry no. NCT00999778.
C1 [Kasari, Connie; Berry, Kathleen] Univ Calif Los Angeles, Dept Human Dev & Psychol, Los Angeles, CA 90024 USA.
[Gulsrud, Amanda; Paparella, Tanya] Univ Calif Los Angeles, Dept Child Psychiat, Los Angeles, CA 90024 USA.
[Hellemann, Gerhard] Univ Calif Los Angeles, Semel Inst Biostat Core, Los Angeles, CA 90024 USA.
RP Kasari, C (reprint author), Univ Calif Los Angeles, Semel Inst 68 268, Los Angeles, CA 90024 USA.
EM Kasari@gseis.ucla.edu
FU NICHD, Autism Center of Excellence [P50-HD-055784]; Determinants of
Social, Communicative; [4]
FX This study was supported by NICHD, Autism Center of Excellence
P50-HD-055784, Determinants of Social, Communicative, and Other Core
Deficits in Autism (Bookheimer, PI) project 4, Optimizing Communication
in Toddlers with Autism (Connie Kasari, PI), Clinical trials. gov no.
NCT00999778. We appreciate the contributions of our therapists and
coders: Janet Bang, Marina Farberov, Amy Fuller, Kelly Goods, Dalia
Kabab, Kathy Lawton, Sara Levitt, Cordelia Ross, and our families and
children.
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NR 36
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0022-006X
EI 1939-2117
J9 J CONSULT CLIN PSYCH
JI J. Consult. Clin. Psychol.
PD JUN
PY 2015
VL 83
IS 3
BP 554
EP 563
DI 10.1037/a0039080
PG 10
WC Psychology, Clinical
SC Psychology
GA CJ0LK
UT WOS:000355167300012
PM 25822242
ER
PT J
AU Dolen, G
AF Doelen, Guel
TI Oxytocin: Parallel Processing in the Social Brain?
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Review
DE 5-HT; oxytocin; vasopressin; autism; schizophrenia; synaptic plasticity
ID FRAGILE-X-SYNDROME; AUTISM SPECTRUM DISORDERS;
RANDOMIZED-CONTROLLED-TRIAL; POSTTRAUMATIC-STRESS-DISORDER; DE-NOVO
MUTATIONS; HYPOTHALAMO-NEUROHYPOPHYSEAL SYSTEM; CEREBROSPINAL-FLUID
OXYTOCIN; POTENTIATED STARTLE PARADIGM; NUCLEUS-ACCUMBENS OXYTOCIN;
REDUCES BACKGROUND ANXIETY
AB Early studies attempting to disentangle the network complexity of the brain exploited the accessibility of sensory receptive fields to reveal circuits made up of synapses connected both in series and in parallel. More recently, extension of this organisational principle beyond the sensory systems has been made possible by the advent of modern molecular, viral and optogenetic approaches. Here, evidence supporting parallel processing of social behaviours mediated by oxytocin is reviewed. Understanding oxytocinergic signalling from this perspective has significant implications for the design of oxytocin-based therapeutic interventions aimed at disorders such as autism, where disrupted social function is a core clinical feature. Moreover, identification of opportunities for novel technology development will require a better appreciation of the complexity of the circuit-level organisation of the social brain.
C1 Johns Hopkins Univ, Sch Med, Wendy Klag Inst Dev Disabil & Autism, Dept Neurosci,Brain Sci Inst, Baltimore, MD 21205 USA.
RP Dolen, G (reprint author), Johns Hopkins Univ, Sch Med, Wendy Klag Inst Dev Disabil & Autism, Dept Neurosci,Brain Sci Inst, Baltimore, MD 21205 USA.
EM gul@jhu.edu
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NR 341
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD JUN
PY 2015
VL 27
IS 6
SI SI
BP 516
EP 535
DI 10.1111/jne.12284
PG 20
WC Endocrinology & Metabolism; Neurosciences
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA CJ1HA
UT WOS:000355233400016
PM 25912257
ER
PT J
AU Frederikse, PH
Kasinathan, C
AF Frederikse, Peter H.
Kasinathan, Chinnaswamy
TI Lens GABA receptors are a target of GABA-related agonists that mitigate
experimental myopia
SO MEDICAL HYPOTHESES
LA English
DT Article
ID FRAGILE-X-SYNDROME; DEVELOPING MOUSE LENS; RAT LENS; MESSENGER-RNAS;
FIBER CELLS; EXPRESSION; BRAIN; MELATONIN; CHICK; EYE
AB Coordinated growth of eye tissues is required to achieve visual acuity. However, visual experience also guides this process. Experimental myopia can be produced by altering light entering the eye, but also by changing light/dark regimens. Drug discovery studies demonstrated that gamma-aminobutyric acid (GABA)-related agonists (e.g., baclofen) will mitigate experimental myopia, and are also drugs studied for their capacity to affect neurodevelopmental disorders that include Fragile X Syndrome and related autism spectrum disorders. GABA receptors thought to mediate these responses in the eye have been studied in the neural retina as well as the cornea and sclera which are both innervated tissues. In addition to neurons, lenses express GAD25/65/67 GABA metabolic enzymes and at least 13 GABA receptor sub-units with developmental expression profiles that match neural development. Evidence that lens GABA receptors are expressed in a cell environment comparable to neurons is seen in the lens expression of AMPA and NMDA glutamate receptors together with an unexpectedly comprehensive array of associated signaling proteins that include post-synaptic-density 95 (PSD95), calcium calmodulin kinase Il alpha (CaMKII alpha), Fragile X Syndrome mental retardation protein (FMRP), ephrin receptors, Ca(V)1.2, 1.3 channels, cyclin-dependent kinase 5 (Cdk5), and neuronal C-src among others. Moreover, lens cells share fundamental molecular regulatory mechanisms that integrate the regulation and function of these genes at the DNA, RNA, and protein levels in neurons. GABA has trophic, growth promoting effects early in neuron development and later assumes its classic inhibitory role in the adult neural system. We hypothesize that the extensive parallels between GABA and glutamate receptor biology in lens and brain identifies the lens as a site of GABA agonist drug action affecting experimental myopia, acting through lens GABA receptors to similarly affect growth in both elongated cell types. (c) 2015 Elsevier Ltd. All rights reserved.
C1 [Frederikse, Peter H.; Kasinathan, Chinnaswamy] Rutgers SDM & BHS, Dept Oral Biol, Newark, NJ 07103 USA.
[Frederikse, Peter H.] Rutgers SDM & BHS, Dept Physiol & Pharmacol, Newark, NJ 07103 USA.
RP Frederikse, PH (reprint author), Rutgers SDM, 185 S Orange Ave C866, Newark, NJ 07103 USA.
EM frederph@sdm.rutgers.edu
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NR 54
TC 0
Z9 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUN
PY 2015
VL 84
IS 6
BP 589
EP 592
DI 10.1016/j.mehy.2015.03.008
PG 4
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CJ3BE
UT WOS:000355357600013
PM 25841296
ER
PT J
AU Krumm, N
Turner, TN
Baker, C
Vives, L
Mohajeri, K
Witherspoon, K
Raja, A
Coe, BP
Stessman, HA
He, ZX
Leal, SM
Bernier, R
Eichler, EE
AF Krumm, Niklas
Turner, Tychele N.
Baker, Carl
Vives, Laura
Mohajeri, Kiana
Witherspoon, Kali
Raja, Archana
Coe, Bradley P.
Stessman, Holly A.
He, Zong-Xiao
Leal, Suzanne M.
Bernier, Raphael
Eichler, Evan E.
TI Excess of rare, inherited truncating mutations in autism
SO NATURE GENETICS
LA English
DT Article
ID DE-NOVO MUTATIONS; EXOME SEQUENCE DATA; SPECTRUM DISORDERS; TRANSMISSION
DISEQUILIBRIUM; DEVELOPMENTAL DELAY; GROWTH-FACTOR; GENES; MODEL;
DELETIONS; SUPPORTS
AB To assess the relative impact of inherited and de novo variants on autism risk, we generated a comprehensive set of exonic single-nucleotide variants (SNVs) and copy number variants (CNVs) from 2,377 families with autism. We find that private, inherited truncating SNVs in conserved genes are enriched in probands (odds ratio = 1.14, P = 0.0002) in comparison to unaffected siblings, an effect involving significant maternal transmission bias to sons. We also observe a bias for inherited CNVs, specifically for small (<100 kb), maternally inherited events (P = 0.01) that are enriched in CHD8 target genes (P = 7.4 x 10(-3)). Using a logistic regression model, we show that private truncating SNVs and rare, inherited CNVs are statistically independent risk factors for autism, with odds ratios of 1.11 (P = 0.0002) and 1.23 (P = 0.01), respectively. This analysis identifies a second class of candidate genes (for example, RIMS 1, CUL7 and LZTR1) where transmitted mutations may create a sensitized background but are unlikely to be completely penetrant.
C1 [Krumm, Niklas; Turner, Tychele N.; Baker, Carl; Vives, Laura; Mohajeri, Kiana; Witherspoon, Kali; Raja, Archana; Coe, Bradley P.; Stessman, Holly A.; Eichler, Evan E.] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98104 USA.
[Raja, Archana; Eichler, Evan E.] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA.
[He, Zong-Xiao; Leal, Suzanne M.] Baylor Coll Med, Dept Mol & Human Genet, Ctr Stat Genet, Houston, TX 77030 USA.
[Bernier, Raphael] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
RP Eichler, EE (reprint author), Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98104 USA.
EM eee@gs.washington.edu
FU US National Institutes of Health [1U01MH100233]; National Institute for
Mental Health [R01MH101221, R01MH100047]; Simons Foundation [SFARI
89368, SFARI 137578]
FX We thank D. Obenshain, D. Hall, B. Koser and S. Novikova for providing
support for usage of the Amazon Cloud and for assistance in the
deposition of SNV and CNV call sets into the National Database for
Autism Research (NDAR). We are grateful to the laboratories of M. Wigler
and M. State for providing early access to exome sequencing data as well
as access to SNP microarray data. We also thank T. Brown for assistance
in editing this manuscript. Funding for this study was provided, in
part, by the US National Institutes of Health (1U01MH100233 to E.E.E.),
by the National Institute for Mental Health (R01MH101221 to E.E.E. and
R01MH100047 to R.B.) and by the Simons Foundation (SFARI 89368 to R.B.
and SFARI 137578 to E.E.E.). E.E.E. is an investigator of the Howard
Hughes Medical Institute. We are grateful to all of the families at the
participating Simons Simplex Collection (SSC) sites, as well as the
principal investigators (A. Beaudet, R. Bernier, J. Constantino, E.
Cook, E. Fombonne, D. Geschwind, R. Goin-Kochel, E. Hanson, D. Grice, A.
Klin, D. Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles,
O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State,
W. Stone, J. Sutcliffe, C. Walsh, Z. Warren and E. Wijsman). We
appreciate obtaining access to phenotypic data on Simons Foundation
Autism Research Initiative (SFARI) Base. Approved researchers can obtain
the SSC population data set described in this study by applying at
https://base.sfari.org/.
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NR 38
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1061-4036
EI 1546-1718
J9 NAT GENET
JI Nature Genet.
PD JUN
PY 2015
VL 47
IS 6
BP 582
EP 588
DI 10.1038/ng.3303
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA CJ3LW
UT WOS:000355386500008
PM 25961944
ER
PT J
AU Angriman, M
Caravale, B
Novelli, L
Ferri, R
Bruni, O
AF Angriman, Marco
Caravale, Barbara
Novelli, Luana
Ferri, Raffaele
Bruni, Oliviero
TI Sleep in Children with Neurodevelopmental Disabilities
SO NEUROPEDIATRICS
LA English
DT Review
DE sleep disorders; neurodevelopmental disabilities; Down syndrome; Fragile
X syndrome; Prader-Willi syndrome; Angelman syndrome; Rett syndrome;
Smith-Magenis syndrome; cerebral palsy; autism spectrum disorders
ID PRADER-WILLI-SYNDROME; SMITH-MAGENIS-SYNDROME; AUTISM SPECTRUM
DISORDERS; FRAGILE-X-SYNDROME; EXCESSIVE DAYTIME SLEEPINESS;
PLACEBO-CONTROLLED TRIAL; GROWTH-HORMONE THERAPY; PERIODIC LIMB
MOVEMENT; ANGELMAN-SYNDROME; RETT-SYNDROME
AB This review describes recent research in pediatric sleep disorders associated with neurodevelopmental disabilities (NDDs) and their treatment. NDDs affect more than 2% of the general population and represent more than 35% of the total cases of children referred to a neuropsychiatric center for sleep problems. Specific clinical and therapeutic aspects of sleep disorders associated with Down syndrome, Fragile X syndrome, Prader-Willi syndrome, Angelman syndrome, Rett syndrome, Smith-Magenis syndrome, cerebral palsy, and autism spectrum disorders are described. Furthermore, the drugs commonly used for sleep disorders in children with NDDs are described. The review clearly highlighted that children with NDDs are often affected by sleep disorders that require appropriate clinical and therapeutic approach to improve quality of life in both patients and families.
C1 [Angriman, Marco] Cent Hosp Bolzano, Dept Pediat, Child Neurol & Neurorehabil Unit, Bolzano, Italy.
[Caravale, Barbara; Novelli, Luana; Bruni, Oliviero] Univ Roma La Sapienza, Dept Dev & Social Psychol, I-00185 Rome, Italy.
[Ferri, Raffaele] Sleep Res Ctr, Oasi Inst IRCCS, IC, Dept Neurol, Troina, Italy.
RP Bruni, O (reprint author), Univ Roma La Sapienza, Dept Dev & Social Psychol, Via Marsi 78, I-00185 Rome, Italy.
EM oliviero.bruni@uniroma1.it
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NR 126
TC 1
Z9 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0174-304X
EI 1439-1899
J9 NEUROPEDIATRICS
JI Neuropediatrics
PD JUN
PY 2015
VL 46
IS 3
BP 199
EP 210
DI 10.1055/s-0035-1550151
PG 12
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA CJ0QU
UT WOS:000355183200005
PM 25918987
ER
PT J
AU Dart, EH
Furlow, CM
Collins, TA
Brewer, E
Gresham, FM
Chenier, KH
AF Dart, Evan H.
Furlow, Christopher M.
Collins, Tai A.
Brewer, Elizabeth
Gresham, Frank M.
Chenier, Katherine H.
TI Peer-Mediated Check-In/Check-Out for Students At-Risk for Internalizing
Disorders
SO SCHOOL PSYCHOLOGY QUARTERLY
LA English
DT Article
DE check-in/check-out; internalizing behavior; multi-tiered service
delivery; peer-mediated; school-based mental health
ID DISRUPTIVE CLASSROOM-BEHAVIOR; HIGH-SCHOOL-STUDENTS; SOCIAL-INTERACTION;
INTERVENTION; ADOLESCENT; EDUCATION; CHILDREN; AUTISM
AB The present study investigated the effectiveness of peer-mediated check-in/check-out (CICO) on the internalizing behaviors of elementary school students. A nonconcurrent multiple-baseline design across participants was utilized to evaluate the intervention's effectiveness for 3 students in 1st and 2nd grade. Two 5th grade students were trained to implement CICO under the supervision of an adult intervention specialist. The peer-mediated CICO procedure was effective for 2 of the 3 participants as evidenced by moderate to large effect sizes; however, all 3 participants were identified as "at-risk" on a universal screener for internalizing problems. The results suggest peer-mediated CICO may be a resource-efficient Tier II strategy to meet the needs of students engaging in internalizing behavior within a multitiered framework of service delivery.
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[Collins, Tai A.] Univ Cincinnati, Sch Human Serv, Cincinnati, OH 45221 USA.
[Gresham, Frank M.; Chenier, Katherine H.] Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
RP Dart, EH (reprint author), Univ So Mississippi, Dept Psychol, 118 Coll Dr 5025, Hattiesburg, MS 39406 USA.
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NR 41
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1045-3830
EI 1939-1560
J9 SCHOOL PSYCHOL QUART
JI Sch. Psychol. Q.
PD JUN
PY 2015
VL 30
IS 2
BP 229
EP 243
DI 10.1037/spq0000092
PG 15
WC Psychology, Educational
SC Psychology
GA CJ2GZ
UT WOS:000355303500007
PM 25286311
ER
PT J
AU Segal, NL
AF Segal, Nancy L.
TI Centenary Celebration for Scottish Missionary Mary Slessor: A Lasting
Legacy for Twins/Twin Research: Twins With Kleinfelter's Syndrome; Twin
Research on Atopic Diseases; Twin Study of Autism; Psychotherapy with
Twins / General Interest: Female Twin Pole-Vaulters; Longest Twin Birth
Interval; Pair of Franco-Cuban Vocalists; Croatian Twin Models
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT News Item
AB The centenary celebration for Scottish missionary, Mary Slessor, took place on February 14, 2015 in Melle, Belgium. Slessor saved many newborn twins and their mothers from death and disownment by members of their community, including their families, who believed twins harbored evil spirits. The events of this unusual and significant gathering are described. Next, twin research and reports concerning Kleinfelter's disease, atopic diseases, autism and psychotherapy are presented. General interest subjects include identical female twin pole-vaulters, the longest twin birth interval, Franco-Cuban twin vocalists, and Croatian twin models.
C1 Calif State Univ Fullerton, Dept Psychol, Fullerton, CA 92834 USA.
RP Segal, NL (reprint author), Calif State Univ Fullerton, Dept Psychol, Fullerton, CA 92834 USA.
EM nsegal@fullerton.edu
CR [Anonymous], 2015, MOTHER INFORMED BOTH
Asteroid, 2015, WIKIPEDIA
Benaiges D., 2014, ANDROLOGIA, V47, P116
Bennett-Smith M, 2013, HUFFINGTON POST
Binder D, 2015, LEXI TORI WEEKS RAIS
Bueltmann A. J., 2011, WHITE QUEEN CANNIBAL
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Finding a balance between two worlds, 2015, NY TIMES, pAR2
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Hester J, 1996, NY TIMES
Inquisitur, 2015, MOTH INF BOTH COULD
Kahr N., 2014, CLIN RESPIR J, V9, P79
Longman J., 2015, NY TIMES
Mary Slessor Foundation, 2015, HER AD FAM
Planetary Society, 2015, AST NAM GUID
Segal NL, 2014, TWIN RES HUM GENET, V17, P134, DOI 10.1017/thg.2014.7
Stevenson J., 2015, LEXI WEEKS SETS POLE
Wikipedia, 2015, PROV DES ASTR
Wright E., 2010, NEW DIR PSYCH, V4, P268
NR 19
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD JUN
PY 2015
VL 18
IS 3
BP 328
EP 333
DI 10.1017/thg.2015.24
PG 6
WC Genetics & Heredity; Obstetrics & Gynecology
SC Genetics & Heredity; Obstetrics & Gynecology
GA CJ2BC
UT WOS:000355288200013
PM 25906830
ER
PT J
AU Eriksson, MA
Lieden, A
Westerlund, J
Bremer, A
Wincent, J
Sahlin, E
Gillberg, C
Fernell, E
Anderlid, BM
AF Eriksson, Mats Anders
Lieden, Agne
Westerlund, Joakim
Bremer, Anna
Wincent, Josephine
Sahlin, Ellika
Gillberg, Christopher
Fernell, Elisabeth
Anderlid, Britt-Marie
TI Rare copy number variants are common in young children with autism
spectrum disorder
SO ACTA PAEDIATRICA
LA English
DT Article
DE Autism; Autism spectrum disorder; Chromosomal microarray; Copy number
variants
ID PARENTAL PSYCHIATRIC-DISORDERS; DE-NOVO MUTATIONS; RISK; CNVS; GENETICS
AB AimSeveral studies have suggested that rare copy number variants (CNVs) are an important genetic contributor to autism spectrum disorders. The aims of the study were to use chromosomal microarray to investigate the presence of rare copy number variants in a population-based cohort of well-characterised young children with autism spectrum disorders and to relate the genetic results to neurodevelopmental profiles and medical conditions.
MethodsWe performed chromosomal microarray on samples from 162 children who had been referred to the Stockholm Autism Centre for Young Children in Sweden after being diagnosed with autism spectrum disorder between 20 and 54months of age.
ResultsPathogenic aberrations were detected in 8.6% of the children and variants of uncertain significance were present in another 8.6%. CNVs were more frequent in children with congenital malformations or dysmorphic features as well as in the subgroup with intellectual disability.
ConclusionOur results support the use of chromosomal microarray methods for the first tier genetic analysis of autism spectrum disorder. However, it is likely in the near future that chromosomal microarray methods will probably be replaced by whole-exome and whole-genome sequencing technologies in clinical genetic testing.
C1 [Eriksson, Mats Anders] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
[Eriksson, Mats Anders] Karolinska Univ Hosp, Astrid Lindgrens Childrens Hosp, Dept Neuropediat, Stockholm, Sweden.
[Eriksson, Mats Anders; Gillberg, Christopher; Fernell, Elisabeth] Gothenburg Univ, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
[Lieden, Agne; Wincent, Josephine; Sahlin, Ellika; Anderlid, Britt-Marie] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
[Lieden, Agne; Wincent, Josephine; Sahlin, Ellika; Anderlid, Britt-Marie] Karolinska Inst, Ctr Mol Med, Stockholm, Sweden.
[Lieden, Agne; Sahlin, Ellika; Anderlid, Britt-Marie] Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden.
[Westerlund, Joakim] Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden.
[Bremer, Anna] Univ Hosp, Div Clin Genet, Linkoping, Sweden.
RP Eriksson, MA (reprint author), Karolinska Univ Hosp, Neuropaediat Dept, S-17176 Stockholm, Sweden.
EM mats.a.eriksson@ki.se
FU Swedish Research Council; Stockholm City Council; Frimurare Barnhuset
Foundation; Linnea and Josef Carlsson Foundation; Kronprinsessan Lovisas
Foundation; Sunnerdahls Foundation; Samariten Foundation; Karolinska
Institutet Center of Neurodevelopmental Disorders; Gillberg
Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg
FX Financial support was given from the Swedish Research Council, Stockholm
City Council, Frimurare Barnhuset Foundation, Linnea and Josef Carlsson
Foundation, Kronprinsessan Lovisas Foundation, Sunnerdahls Foundation,
Samariten Foundation, Karolinska Institutet Center of Neurodevelopmental
Disorders and Gillberg Neuropsychiatry Centre, Sahlgrenska Academy,
University of Gothenburg.
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NR 34
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0803-5253
EI 1651-2227
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD JUN
PY 2015
VL 104
IS 6
BP 610
EP 618
DI 10.1111/apa.12969
PG 9
WC Pediatrics
SC Pediatrics
GA CI1TR
UT WOS:000354528100021
PM 25661985
ER
PT J
AU Bystrom, KM
Persson, CAL
AF Bystrom, Kristina M.
Persson, Cristina A. Lundqvist
TI The Meaning of Companion Animals for Children and Adolescents with
Autism: The Parents' Perspective
SO ANTHROZOOS
LA English
DT Article
DE autism spectrum disorders; child development; human-companion animal
interaction
ID SPECTRUM DISORDERS; THERAPY; IMPACT
AB The aim of this study was to understand parents' perspectives on how children and adolescents with autism spectrum disorders (ASD) benefit from a relationship with companion animals. Parents were invited to participate in focus-group discussions. One open-ended question with follow-up questions was asked and the parents' responses were subsequently categorized. Three main themes emerged: the quality of the relationship with the companion animal; increased interaction with people; and optimization of the child's function and development. The results show that companion animals can contribute to social and behavioral development support, and improved mental health and quality of life. The children's and adolescents' interests and activities with companion animals were more social than non-social and of different quality than the restricted and repetitive activities in which children with ASD are normally engaged. Our findings describe a complementary developmental support for this vulnerable group of children and adolescents, which give them possibilities for expanded social contacts, diminished anxiety and depression, and facilitated learning.
C1 [Bystrom, Kristina M.] Swedish Univ Agr Sci, Dept Work Sci Business Econ & Environm Psychol, Alnarp, Sweden.
[Persson, Cristina A. Lundqvist] Lund Univ, Dept Psychol, S-22100 Lund, Sweden.
[Bystrom, Kristina M.; Persson, Cristina A. Lundqvist] Skaraborg Inst Res & Dev, Skovde, Sweden.
RP Bystrom, KM (reprint author), Habilitering & Halsa, Habiliteringen Skaraborg, Skaraborgsgatan 19A, S-54150 Skovde, Sweden.
EM kristina.bystrom@vgregion.se
FU Skaraborg Institute for Research and Development, Skovde, Sweden
FX This study was supported by grants from the Skaraborg Institute for
Research and Development, Skovde, Sweden. Special thanks go to Professor
Patrik Grahn, Department of Work Science, Business Economics and
Environmental Psychology at the Swedish University of Agricultural
Sciences.
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NR 45
TC 0
Z9 0
PU BLOOMSBURY PUBLISHING PLC
PI LONDON
PA 50 BEDFORD SQ, LONDON, WC1B 3DP, ENGLAND
SN 0892-7936
EI 1753-0377
J9 ANTHROZOOS
JI Anthrozoos
PD JUN
PY 2015
VL 28
IS 2
BP 263
EP 275
DI 10.2752/089279315X14219211661813
PG 13
WC Anthropology; Environmental Studies; Sociology; Veterinary Sciences
SC Anthropology; Environmental Sciences & Ecology; Sociology; Veterinary
Sciences
GA CI8SD
UT WOS:000355041100006
ER
PT J
AU Light, J
Mcnaughton, D
AF Light, Janice
Mcnaughton, David
TI Designing AAC Research and Intervention to Improve Outcomes for
Individuals with Complex Communication Needs
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Editorial Material
DE AAC; Autism; Cerebral palsy; Aphasia; Amyotrophic lateral sclerosis;
Intellectual disability; ICF; Intervention; Outcomes; Research
ID LONG-TERM OUTCOMES; ALTERNATIVE COMMUNICATION;
DEVELOPMENTAL-DISABILITIES; REQUIRE AAC; AIDED AAC; ADULTS; PEOPLE;
INCLUSION; CHILDREN; AUTISM
AB There is a rapidly growing body of research that demonstrates the positive effects of augmentative and alternative communication (AAC) intervention on the communication of children and adults with complex communication needs. Despite the positive impact of many AAC interventions, however, many individuals with complex communication needs continue to experience serious challenges participating in educational, vocational, healthcare, and community environments. In this paper, we apply the framework proposed by the International Classification of Functioning, Disability and Health (ICF) to illustrate the need to re-think AAC intervention to improve outcomes for individuals with complex communication needs, and to foster a new generation of intervention research that will provide a solid foundation for improved services. Specifically, the paper emphasizes the need to take a more holistic view of communication intervention and highlights the following key principles to guide AAC intervention and research: (a) build on the individual's strengths and focus on the integration of skills to maximize communication, (b) focus on the individual's participation in real-world contexts, (c) address psychosocial factors as well as skills, and (d) attend to extrinsic environmental factors as well as intrinsic factors related to the individual who requires AAC.
C1 [Light, Janice] Penn State Univ, Dept Commun Sci & Disorders, University Pk, PA 16802 USA.
[Mcnaughton, David] Penn State Univ, Dept Educ Psychol Counseling & Special Educ, University Pk, PA 16802 USA.
RP Light, J (reprint author), Penn State Univ, Dept Commun Sci & Disorders, 308 Ford Bldg, University Pk, PA 16802 USA.
EM JCL4@psu.edu
FU U.S. Department of Health and Human Services, National Institute on
Disability, Independent Living, and Rehabilitation Research (NIDILRR)
[H133E140026]
FX The contents of this paper were developed, in part, under a grant (The
RERC on AAC) from the U.S. Department of Health and Human Services,
National Institute on Disability, Independent Living, and Rehabilitation
Research (NIDILRR) [grant number H133E140026]. However, the contents do
not necessarily represent the policy of the funding agency, and you
should not assume endorsement by the federal government
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NR 80
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
EI 1477-3848
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD JUN
PY 2015
VL 31
IS 2
BP 85
EP 96
DI 10.3109/07434618.2015.1036458
PG 12
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA CI5KL
UT WOS:000354794600001
PM 25904008
ER
PT J
AU Ferm, UM
Claesson, BK
Ottesjo, C
Ericsson, S
AF Ferm, Ulrika M.
Claesson, Britt K.
Ottesjo, Cajsa
Ericsson, Stina
TI Participation and Enjoyment in Play with a Robot between Children with
Cerebral Palsy who use AAC and their Peers
SO AUGMENTATIVE AND ALTERNATIVE COMMUNICATION
LA English
DT Article
DE Augmentative and alternative communication; Cerebral palsy; Children;
Complex communication needs; Peers; Robotics; Play; Participation;
Enjoyment
ID COMPLEX COMMUNICATION NEEDS; ALTERNATIVE COMMUNICATION; YOUNG-CHILDREN;
AGED CHILDREN; CONVERSATION; AUTISM; TECHNOLOGIES; ORGANIZATION;
EXPERIENCES; PARENTS
AB This study explores children with complex communication needs, their peers and adult support persons in play with the talking and moving robot LekBot. Two triads were filmed playing with LekBot at pre-school. LekBot was developed to facilitate independent and enjoyable play on equal terms for children with significant communication disabilities and their peers. Using Conversation Analysis, participatory symmetry and enjoyment were investigated in relation to spoken and gestural communication, embodied stance, gaze, and affective display. Data originated from three video-recorded sessions that were approximately 2 hours long. Four different interaction situations were identified and explored: Participatory Asymmetry, Adult Facilitation, Greater Participatory Symmetry and Creativity, and Turn-taking and Enjoyable Play with LekBot. Neither participatory symmetry nor enjoyment were easily achieved in the play sessions and may require considerable effort, including adult involvement, but creative, spontaneous and highly enjoyable play, correlating with participatory symmetry to various degrees, was observed in a few instances. The findings are discussed with regard to play, AAC and the future development of robots to facilitate play.
C1 [Ferm, Ulrika M.; Claesson, Britt K.] Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, DART Ctr AAC&AT, S-41104 Gothenburg, Sweden.
[Ottesjo, Cajsa] Univ Gothenburg, Dept Philosophy Theory Sci & Linguist, Gothenburg, Sweden.
[Ericsson, Stina] Linnaeus Univ, Dept Swedish, Vaxjo, Sweden.
RP Ferm, UM (reprint author), Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, DART Ctr AAC&AT, Kruthusgatan 17, S-41104 Gothenburg, Sweden.
EM ulrika.ferm@vgregion.se
FU Swedish Governmental Agency for Innovation Systems VINNOVA; Promobilia
Foundation; Petter Silfverskiold Foundation; Research Council of the
Swedish National Association for Disabled Children and Young People
FX LekBot has received financial support from the Swedish Governmental
Agency for Innovation Systems VINNOVA, The Promobilia Foundation, The
Petter Silfverskiold Foundation, and The Research Council of the Swedish
National Association for Disabled Children and Young People.
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NR 59
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-4618
EI 1477-3848
J9 AUGMENT ALTERN COMM
JI Augment. Altern. Commun.
PD JUN
PY 2015
VL 31
IS 2
BP 108
EP 123
DI 10.3109/07434618.2015.1029141
PG 16
WC Audiology & Speech-Language Pathology; Rehabilitation
SC Audiology & Speech-Language Pathology; Rehabilitation
GA CI5KL
UT WOS:000354794600003
PM 25921358
ER
PT J
AU Evans, DW
Lazar, SM
Boomer, KB
Mitchel, AD
Michael, AM
Moore, GJ
AF Evans, David W.
Lazar, Steven M.
Boomer, K. B.
Mitchel, Aaron D.
Michael, Andrew M.
Moore, Gregory J.
TI Social Cognition and Brain Morphology: Implications for Developmental
Brain Dysfunction
SO BRAIN IMAGING AND BEHAVIOR
LA English
DT Article
DE MRI; Brain morphology; Autism spectrum disorder; Social cognition;
Quantitative traits
ID AUTISM SPECTRUM DISORDER; HIGH-FUNCTIONING AUTISM; NORMAL
SEX-DIFFERENCES; ASPERGER-SYNDROME; GENERAL-POPULATION; SYSTEMATIZING
QUOTIENT; HIPPOCAMPAL VOLUMES; HEAD CIRCUMFERENCE; CEREBRAL ASYMMETRY;
EMPATHY QUOTIENT
AB The social-cognitive deficits associated with several neurodevelopmental and neuropsychiatric disorders have been linked to structural and functional brain anomalies. Given the recent appreciation for quantitative approaches to behavior, in this study we examined the brain-behavior links in social cognition in healthy young adults from a quantitative approach. Twenty-two participants were administered quantitative measures of social cognition, including the social responsiveness scale (SRS), the empathizing questionnaire (EQ) and the systemizing questionnaire (SQ). Participants underwent a structural, 3-T magnetic resonance imaging (MRI) procedure that yielded both volumetric (voxel count) and asymmetry indices. Model fitting with backward elimination revealed that a combination of cortical, limbic and striatal regions accounted for significant variance in social behavior and cognitive styles that are typically associated with neurodevelopmental and neuropsychiatric disorders. Specifically, as caudate and amygdala volumes deviate from the typical R > L asymmetry, and cortical gray matter becomes more R > L asymmetrical, overall SRS and Emotion Recognition scores increase. Social Avoidance was explained by a combination of cortical gray matter, pallidum (rightward asymmetry) and caudate (deviation from rightward asymmetry). Rightward asymmetry of the pallidum was the sole predictor of Interpersonal Relationships and Repetitive Mannerisms. Increased D-scores on the EQ-SQ, an indication of greater systemizing relative to empathizing, was also explained by deviation from the typical R > L asymmetry of the caudate.
These findings extend the brain-behavior links observed in neurodevelopmental disorders to the normal distribution of traits in a healthy sample.
C1 [Evans, David W.; Lazar, Steven M.; Michael, Andrew M.; Moore, Gregory J.] Geisinger Bucknell Autism & Dev Med Ctr, Lewisburg, PA 17837 USA.
[Evans, David W.; Lazar, Steven M.; Mitchel, Aaron D.] Bucknell Univ, Program Neurosci, Lewisburg, PA 17837 USA.
[Boomer, K. B.] Bucknell Univ, Dept Math, Lewisburg, PA 17837 USA.
[Moore, Gregory J.] Geisinger Hlth Syst, Dept Radiol, Danville, PA USA.
RP Evans, DW (reprint author), Geisinger Bucknell Autism & Dev Med Ctr, 120 Hamm Dr,Suite 2, Lewisburg, PA 17837 USA.
EM dwevans@bucknell.edu
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NR 75
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1931-7557
EI 1931-7565
J9 BRAIN IMAGING BEHAV
JI Brain Imaging Behav.
PD JUN
PY 2015
VL 9
IS 2
BP 264
EP 274
DI 10.1007/s11682-014-9304-1
PG 11
WC Neuroimaging
SC Neurosciences & Neurology
GA CI7TB
UT WOS:000354966600012
PM 24788335
ER
PT J
AU Coles, B
AF Coles, Barbara
TI A "Suitable Person': an "insider' perspective
SO BRITISH JOURNAL OF LEARNING DISABILITIES
LA English
DT Article
DE Autism; challenging behaviour; Health & social care policy and practice;
independent living; intellectual disability; Parenting
AB Accessible Summary The purpose of this article is to demonstrate how insider' research can make an effective contribution to policy debates. It draws on a study which looked at the experiences of twelve parents in England who manage a Direct Payment for an adult child who has a learning disability and complex support needs. This article matters to people with learning disabilities because it reveals some of the challenges faced by some parents who are managing Direct Payments on their behalf.
SummaryThis article draws on a doctoral study carried out across seven counties in England which focused on twelve parents' experiences of carrying out the role of a suitable person' (SP') by managing a direct payment for an adult child (living in her/his own home) who has severe learning disabilities, autism and very complex support needs. Evidence came from naturally occurring qualitative data using (auto) ethnography. The research exposed how vital these parents' expertise and skills are to their adult children, but also how they themselves are being used within the care system. This article considers whether research has greater impact if a researcher who has direct experience of the research problem has conducted it. It argues that insider' research can uncover a unique perspective of some of the issues that directly affect the lives of SP'. In terms of impact', how seriously such research is taken, especially if the findings run counter to much of the existing literature, as it did in this study, remains to be seen.
C1 Univ Bristol, Sch Policy Studies, Fac Social Sci & Law, Norah Fry Res Ctr, Bristol BS8 1TZ, Avon, England.
RP Coles, B (reprint author), Univ Bristol, Sch Policy Studies, Fac Social Sci & Law, Norah Fry Res Ctr, 8 Priory Rd, Bristol BS8 1TZ, Avon, England.
EM mhxbc@my.bristol.ac.uk
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Barnes C., 2014, DISABLING BARRIERS E, P37
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Department of Health, 2009, GUID DIR PAYM COMM C
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Hammersley M., 2009, ETHNOGRAPHY PRINCIPA, V3rd
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NR 21
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1354-4187
EI 1468-3156
J9 BRIT J LEARN DISABIL
JI Brit. J. Learn. Disabil.
PD JUN
PY 2015
VL 43
IS 2
SI SI
BP 135
EP 141
DI 10.1111/bld.12125
PG 7
WC Education, Special
SC Education & Educational Research
GA CI3IF
UT WOS:000354640600009
ER
PT J
AU Murtaza, M
Jolly, LA
Gecz, J
Wood, SA
AF Murtaza, Mariyam
Jolly, Lachlan A.
Gecz, Jozef
Wood, Stephen A.
TI La FAM fatale: USP9X in development and disease
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Ubiquitin; Fat facets; Embryo; Stem cells
ID FACETS DEUBIQUITINATING ENZYME; UBIQUITIN LIGASE ITCH; ALPHA-SYNUCLEIN
FATE; EMBRYONIC STEM-CELLS; DEUBIQUITYLATING ENZYME; BETA-CATENIN;
PROLYL HYDROXYLATION; PROTEIN TRAFFICKING; EXPRESSION ANALYSIS; NEURONAL
MIGRATION
AB Deubiquitylating enzymes (DUBs), act downstream of ubiquitylation. As such, these post-posttranslational modifiers function as the final arbitrators of a protein substrate's ubiquitylation status, thus regulating its fate. In most instances, DUBs moderate the absolute level of a substrate, its locality or activity, rather than being an "all-or-none'' phenomenon. Yet, disruption of this quantitative regulation can produce dramatic qualitative differences. The ubiquitin-specific protease 9X (USP9X/FAM) is a substrate-specific DUB, which displays an extraordinarily high level of sequence conservation from Drosophila to mammals. It is primarily the recent revelations of USP9X's pivotal role in human cancers, both as oncogene or tumour suppressor, in developmental disorders including intellectual disability, epilepsy, autism and developmental delay that has led to a subsequent re-examination of its molecular and cellular functions. Results from experimental animal models have implicated USP9X in neurodegeneration, including Parkinson's and Alzheimer's disease, as well as autoimmune diseases. In this review, we describe the current and accumulated knowledge on the molecular, cellular and developmental aspects of USP9X function within the context of the biological consequences during normal development and disease.
C1 [Murtaza, Mariyam; Wood, Stephen A.] Griffith Univ, Eskitis Inst Drug Discovery, Brisbane, Qld 4111, Australia.
[Jolly, Lachlan A.; Gecz, Jozef] Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia.
[Jolly, Lachlan A.; Gecz, Jozef] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.
RP Wood, SA (reprint author), Griffith Univ, Eskitis Inst Drug Discovery, Brisbane, Qld 4111, Australia.
EM s.wood@griffith.edu.au
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NR 120
TC 0
Z9 0
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD JUN
PY 2015
VL 72
IS 11
BP 2075
EP 2089
DI 10.1007/s00018-015-1851-0
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CI6PV
UT WOS:000354883800003
PM 25672900
ER
PT J
AU Bearss, K
Burrell, TL
Stewart, L
Scahill, L
AF Bearss, Karen
Burrell, T. Lindsey
Stewart, Lindsay
Scahill, Lawrence
TI Parent Training in Autism Spectrum Disorder: What's in a Name?
SO CLINICAL CHILD AND FAMILY PSYCHOLOGY REVIEW
LA English
DT Review
DE Autism spectrum disorder; Parent training; Parent-mediated intervention;
Psychoeducation; Care coordination
ID PERVASIVE DEVELOPMENTAL DISORDERS; RANDOMIZED CONTROLLED-TRIAL;
OF-THE-LITERATURE; YOUNG-CHILDREN; EARLY INTERVENTION; MENTAL-HEALTH;
MEDICAL HOME; MEDIATED INTERVENTION; DISRUPTIVE BEHAVIOR;
PRESCHOOL-CHILDREN
AB Parent training (PT) is well understood as an evidence-based treatment for typically developing children with disruptive behavior. Within the field of autism spectrum disorder (ASD), the term parent training has been used to describe a wide range of interventions including care coordination, psychoeducation, treatments for language or social development, as well as programs designed to address maladaptive behaviors. As a result, the meaning of "parent training" in ASD is profoundly uncertain. This paper describes the need to delineate the variants of PT in ASD and offers a coherent taxonomy. Uniform characterization of PT programs can facilitate communication with families, professionals, administrators, and third-party payers. Moreover, it may also serve as a framework for comparing and contrasting PT programs. In support of the taxonomy, a purposive sampling of the literature is presented to illustrate the range of parent training interventions in ASD.
C1 [Bearss, Karen; Burrell, T. Lindsey; Scahill, Lawrence] Emory Univ, Sch Med, Childrens Healthcare Atlanta, Marcus Autism Ctr, Atlanta, GA 30329 USA.
[Stewart, Lindsay] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA.
RP Bearss, K (reprint author), Emory Univ, Sch Med, Childrens Healthcare Atlanta, Marcus Autism Ctr, 1920 Briarcliff Rd,NE, Atlanta, GA 30329 USA.
EM karen.bearss@emory.edu
FU National Institute of Mental Health NIMH [R01 MH081148]; Healthcare
Innovation Program/Atlanta Clinical & Translational Research Seed Grant
Program; National Center for Research Resources (NCRR) of the National
Institutes of Health (NIH) [UL1 RR024139, 5KL2RR024138]; NIH roadmap for
Medical Research
FX This publication was made possible by the following grants: the National
Institute of Mental Health NIMH R01 MH081148 (principal investigator: L.
Scahill); Healthcare Innovation Program/Atlanta Clinical & Translational
Research Seed Grant Program. This publication was also made possible by
a Clinical and Translational Scholar Award (CTSA) Grant Number UL1
RR024139 and 5KL2RR024138 (principal investigator: K Bearss) from the
National Center for Research Resources (NCRR), a component of the
National Institutes of Health (NIH), and NIH roadmap for Medical
Research. Its contents are solely the responsibility of the authors and
do not necessarily represent the official view of NCRR or NIH.
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NR 103
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1096-4037
EI 1573-2827
J9 CLIN CHILD FAM PSYCH
JI Clin. Child Fam. Psychol. Rev.
PD JUN
PY 2015
VL 18
IS 2
BP 170
EP 182
DI 10.1007/s10567-015-0179-5
PG 13
WC Psychology, Clinical
SC Psychology
GA CI0FC
UT WOS:000354410900004
PM 25722072
ER
PT J
AU Bearss, K
Burrell, TL
Stewart, L
Scahill, L
AF Bearss, Karen
Burrell, T. Lindsey
Stewart, Lindsay
Scahill, Lawrence
TI Parent Training in Autism Spectrum Disorder: What's in a Name? (vol 18,
pg 170, 2015)
SO CLINICAL CHILD AND FAMILY PSYCHOLOGY REVIEW
LA English
DT Correction
C1 [Bearss, Karen; Burrell, T. Lindsey; Scahill, Lawrence] Emory Univ, Sch Med, Childrens Healthcare Atlanta, Marcus Autism Ctr, Atlanta, GA 30329 USA.
[Stewart, Lindsay] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA.
RP Bearss, K (reprint author), Emory Univ, Sch Med, Childrens Healthcare Atlanta, Marcus Autism Ctr, 1920 Briarcliff Rd,NE, Atlanta, GA 30329 USA.
EM karen.bearss@emory.edu
CR Bearss K, 2015, CLIN CHILD FAM PSYCH, V18, P170, DOI 10.1007/s10567-015-0179-5
NR 1
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1096-4037
EI 1573-2827
J9 CLIN CHILD FAM PSYCH
JI Clin. Child Fam. Psychol. Rev.
PD JUN
PY 2015
VL 18
IS 2
BP 183
EP 183
DI 10.1007/s10567-015-0183-9
PG 1
WC Psychology, Clinical
SC Psychology
GA CI0FC
UT WOS:000354410900005
PM 25840684
ER
PT J
AU Silva, GFM
Raposo, A
Suplino, M
AF Mireya Silva, Greis F.
Raposo, Alberto
Suplino, Maryse
TI Exploring Collaboration Patterns in a Multitouch Game to Encourage
Social Interaction and Collaboration Among Users with Autism Spectrum
Disorder
SO COMPUTER SUPPORTED COOPERATIVE WORK-THE JOURNAL OF COLLABORATIVE
COMPUTING
LA English
DT Article
DE Autism spectrum disorder; Collaborative games; Collaboration patterns;
Multitouch tabletop; User study
ID CHILDREN
AB In this paper, we present a design and evaluation of four Collaboration Patterns on a multitouch collaborative game designed to encourage collaboration among people diagnosed with ASD (autism spectrum disorder). We define Collaboration Patterns as collaborative interaction strategies on elements in a multiuser interface. The patterns presented here were designed according to both recommendations from experts in ASD and requirements of a group of youths with high ASD-related impairment in their social interactions and were inspired by collaborative methods used in other studies. The proposed Collaboration Patterns were evaluated using research criteria relating to social interaction actions and collaborative tasks achieved by users during a multitouch game. The evaluation results suggest that each Collaboration Pattern motivates the need for collaboration and encourages creation of social interaction expressions among users. The applied sequence of patterns gradually encouraged collaborative activities and verbal and gestural interaction expressions among users. The significant characteristics of the proposed Collaboration Patterns allow us to suggest that they might be used in other collaborative applications aimed at fostering social interaction and collaboration among people with ASD.
C1 [Mireya Silva, Greis F.; Raposo, Alberto] Pontifical Cathol Univ Rio de Janeiro PUC Rio, Dept Informat, BR-22451900 Rio De Janeiro, Brazil.
[Suplino, Maryse] Ann Sullivan Inst, BR-20780170 Rio De Janeiro, Brazil.
RP Silva, GFM (reprint author), Pontifical Cathol Univ Rio de Janeiro PUC Rio, Dept Informat, BR-22451900 Rio De Janeiro, Brazil.
EM gcalpa@inf.puc-rio.br; abraposo@inf.puc-rio.br;
instituto.ann.sullivan@gmail.com
FU CAPES; CNPq [process 310607/2013-2]; FAPERJ [process 190.243/2013]
FX Greis Silva thanks CAPES, CNPq and FAPERJ for supporting this research.
Alberto Raposo thanks CNPq for the individual grant (process
310607/2013-2) and FAPERJ (Assistive Technology Program, process
190.243/2013).
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NR 29
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0925-9724
EI 1573-7551
J9 COMPUT SUPP COOP W J
JI Comput. Support. Coop. Work
PD JUN
PY 2015
VL 24
IS 2-3
SI SI
BP 149
EP 175
DI 10.1007/s10606-014-9214-1
PG 27
WC Computer Science, Interdisciplinary Applications
SC Computer Science
GA CI7PX
UT WOS:000354957500005
ER
PT J
AU Cascio, MA
AF Cascio, M. Ariel
TI Cross-Cultural Autism Studies, Neurodiversity, and Conceptualizations of
Autism
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Editorial Material
ID DEVELOPMENTAL-DISABILITIES; SPECTRUM DISORDERS; JEWISH CHILDREN;
PARENTS; POLICY; ISSUE
C1 Case Western Reserve Univ, Cleveland, OH 44106 USA.
RP Cascio, MA (reprint author), Case Western Reserve Univ, Cleveland, OH 44106 USA.
EM ariel.cascio@case.edu
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NR 36
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD JUN
PY 2015
VL 39
IS 2
SI SI
BP 207
EP 212
DI 10.1007/s11013-015-9450-y
PG 6
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA CI7QC
UT WOS:000354958100001
PM 25930688
ER
PT J
AU Rios, C
Andrada, BC
AF Rios, Clarice
Andrada, Barbara Costa
TI The changing face of autism in Brazil
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Article
DE Autism; Public policies; Disability; Mental health; Identity politics
ID CHALLENGES; SEARCH
AB At the end of 2012, after intensive lobbying by parent activist associations, a federal law recognized autism as a "disability for all legal purposes" in Brazil. Defining autism as a disability was more than a change of legal status to guarantee social benefits. It was also a political maneuver, orchestrated by parent associations, aimed to take the responsibility for treatment away from the public mental health network of services. This article examines the controversies that have set parent associations in direct antagonism with mental health professionals in the public health system. We draw from ethnographic data and theoretical discussions in the field of disability studies to situate these controversies within the context of a larger debate on the relationship between health, rights, and citizenship. We found similarities between the ethical and political goals of parent activists and mental health professionals in Brazil, but we argue that the main cause of dissent is the role that each of these social actors assigns to identity politics in their clinical and political projects.
C1 [Rios, Clarice; Andrada, Barbara Costa] Univ Estado Rio De Janeiro, Inst Social Med, BR-20550900 Rio De Janeiro, Brazil.
RP Rios, C (reprint author), Univ Estado Rio De Janeiro, Inst Social Med, Rua Sao Francisco Xavier 524, BR-20550900 Rio De Janeiro, Brazil.
EM clarice.r@gmail.com; barbarafcosta@hotmail.com
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NR 57
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD JUN
PY 2015
VL 39
IS 2
SI SI
BP 213
EP 234
DI 10.1007/s11013-015-9448-5
PG 22
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA CI7QC
UT WOS:000354958100002
PM 25842350
ER
PT J
AU Cascio, MA
AF Cascio, M. Ariel
TI Rigid Therapies, Rigid Minds: Italian Professionals' Perspectives on
Autism Interventions
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Article
DE Autism; Ethnography; Health and human services; Italy; Metaphor
ID CHILDREN; NEURODIVERSITY; SPECTRUM; DISORDER; METAPHOR
AB Many therapies, interventions, and programs seek to improve outcomes and quality of life for people diagnosed with autism spectrum conditions. This paper addresses Italian professionals' perspectives on a variety of such interventions, including TEACCH, ABA, Defeat Autism Now!, and Doman-Delacato. Drawing on participant-observation and interviews collected in 2012-2013 in a northern region of Italy, it highlights the theme of "rigidity" that appears in professionals' discourses about both the characteristics of people with autism and the potential risks of adhering too strictly to any particular treatment protocol. The co-occurrence of the theme of rigidity across different domains demonstrates a way in which diagnostic characteristics become metaphors for medical practice. This paper proposes that such discursive moves may help bridge the gap between people with autism and people who work with them because a key attribute of people with autism-thinking and/or acting rigidly-is also a potential pitfall for people without autism.
C1 Case Western Reserve Univ, Cleveland, OH 44106 USA.
RP Cascio, MA (reprint author), Case Western Reserve Univ, Cleveland, OH 44106 USA.
EM ariel.cascio@case.edu
FU Institute of International Education Fulbright Grant; Dissertation
Research Assistance Grant; Baker Nord Center for the Humanities Graduate
Research Grant at Case Western Reserve University; Arts & Sciences
Dissertation Fellowship at Case Western Reserve University
FX This submission represents original work and has not been submitted or
published elsewhere. Portions of this work were presented on March 19,
2014 at the Society for Applied Anthropology Annual Meeting in
Albuquerque, NM, under the title " 'This Is the Italian Variant on
TEACCH': Italian Adaptation of a North Carolina Autism Service Model."
Research for this article was funded by an Institute of International
Education Fulbright Grant, academic year 2012-2013; a Dissertation
Research Assistance Grant under the supervision of Eileen-Anderson-Fye;
a Baker Nord Center for the Humanities Graduate Research Grant at Case
Western Reserve University; and an Arts & Sciences Dissertation
Fellowship at Case Western Reserve University. Several Italian
individuals and organizations made this research possible including
Professor Roberto Malighetti and the Universita degli Studi di
Milano-Bicocca; Cascina Rossago; Cooperativa Aurora 2000 and the Spazio
Autismo; Cooperativa I Percorsi; Cooperativa Spazio Aperto Servizi;
Fondazione Istitute Sacra Famiglia ONLUS; Gruppo Asperger ONLUS; and
Progetto Filippide.
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NR 56
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD JUN
PY 2015
VL 39
IS 2
SI SI
BP 235
EP 253
DI 10.1007/s11013-015-9439-6
PG 19
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA CI7QC
UT WOS:000354958100003
PM 25743186
ER
PT J
AU Sarrett, JC
AF Sarrett, Jennifer C.
TI Custodial Homes, Therapeutic Homes, and Parental Acceptance: Parental
Experiences of Autism in Kerala, India and Atlanta, GA USA
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Article
DE Autism Spectrum Disorders (ASD); Cross-cultural; India; Homes; Parental
attitudes
ID SPECTRUM DISORDER; YOUNG-CHILDREN; SOUTH-INDIA; DISABILITY; PERCEPTIONS;
WORLDS; IMPACT; ASD
AB The home is a critical place to learn about cultural values of childhood disability, including autism and intellectual disabilities. The current article describes how the introduction of autism into a home and the availability of intervention options change the structure and meaning of a home and reflect parental acceptance of a child's autistic traits. Using ethnographic data from Kerala, India and Atlanta, GA USA, a description of two types of homes are developed: the custodial home, which is primarily focused on caring for basic needs, and the therapeutic home, which is focused on changing a child's autistic traits. The type of home environment is respondent to cultural practices of child rearing in the home and influences daily activities, management, and care in the home. Further, these homes differ in parental acceptance of their autistic children's disabilities, which is critical to understand when engaging in international work related to autism and intellectual disability. It is proposed that parental acceptance can be fostered through the use of neurodiverse notions that encourage autism acceptance.
C1 Emory Univ, Atlanta, GA 30322 USA.
RP Sarrett, JC (reprint author), Emory Univ, Atlanta, GA 30322 USA.
EM jsarret@emory.edu
FU Organization for Autism Research; Emory University
FX We thank the Organization for Autism Research and Emory University for
supporting this research as well as Ariel Cascio for organizing this
special issue. We also thank the families, professionals, and children
who participated in this project.
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NR 57
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD JUN
PY 2015
VL 39
IS 2
SI SI
BP 254
EP 276
DI 10.1007/s11013-015-9441-z
PG 23
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA CI7QC
UT WOS:000354958100004
PM 25772598
ER
PT J
AU Brezis, RS
Weisner, TS
Daley, TC
Singhal, N
Barua, M
Chollera, SP
AF Brezis, Rachel S.
Weisner, Thomas S.
Daley, Tamara C.
Singhal, Nidhi
Barua, Merry
Chollera, Shreya P.
TI Parenting a Child with Autism in India: Narratives Before and After a
Parent-Child Intervention Program
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Article
DE Autism; India; Parents; Intervention; Five Minute Speech Sample;
Socioeconomic status (SES)
ID RELATIVES EXPRESSED EMOTION; SCHIZOPHRENIA; DISABILITY; FAMILIES;
MOTHERS; PERCEPTIONS; CHANDIGARH; IMPACT
AB In many low and middle income countries where autism-related resources are scarce, interventions must rely on family and parents. A 3-month Parent-Child Training Program (PCTP) at Action For Autism, New Delhi, India is aimed at empowering and educating parents, encouraging acceptance of their child, and decreasing parent stress. Forty couples were asked to describe their child with autism using the Five Minute Speech Sample (FMSS), an open-ended narrative method, before and after the program. Parents described a wide range of child behaviors, primarily social and cognitive skills. While all families were of a relatively affluent strata compared to the general Indian population, there were nonetheless significant differences in parents' narratives based on their income levels. Coming into the program, parents with relatively less income focused on their child's immediate and material needs, while higher income parents discussed their parental roles and vision for society. After the PCTP, parents were more likely to reflect on their child beyond comparisons to 'normality,' and beyond the here-and-now. Mothers were more likely than fathers to reflect on themselves and their relationships with their child. Understanding parents' experiences and narratives is essential for the evaluation of interventions such as the PCTP, as Indian parents are incorporated into a growing global network of 'parents of children with autism.'.
C1 [Brezis, Rachel S.; Chollera, Shreya P.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Ctr Culture & Hlth, Los Angeles, CA 90024 USA.
[Brezis, Rachel S.] Interdisciplinary Ctr, Sch Psychol, Herzliyya, Israel.
[Weisner, Thomas S.] Univ Calif Los Angeles, Dept Psychiat, Semel Inst, Ctr Culture & Hlth, Los Angeles, CA 90024 USA.
[Weisner, Thomas S.] Univ Calif Los Angeles, Dept Anthropol, Los Angeles, CA 90024 USA.
[Daley, Tamara C.] Westat Corp, Durham, NC USA.
[Singhal, Nidhi; Barua, Merry] Act Autism, New Delhi, India.
RP Brezis, RS (reprint author), Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Ctr Culture & Hlth, Los Angeles, CA 90024 USA.
EM brezisrs@gmail.com
FU Center for Culture and Health (Semel Institute, Department of
Psychiatry, UCLA); Foundation for Psychocultural Research
FX The authors wish to thank the families who participated in the study.
Assistance to the project was provided by Deepali Taneja, Sachita
Suryanarayan, Simi Sunny, Rubina Pradhan, Tanvi Behl and Shaivalini
Singh at AFA, and by Gail Fox Adams, Avani Bedagkar, Navjot Sandhu, and
Fatima Burney at UCLA. The Center for Culture and Health (Semel
Institute, Department of Psychiatry, UCLA) also provided support. The
project is part of the Culture, Brain, Development, and Mental Health
Program (CBDMH), [http://cbdmh.org] funded by the Foundation for
Psychocultural Research, Robert Lemelson, President.
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NR 46
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD JUN
PY 2015
VL 39
IS 2
SI SI
BP 277
EP 298
DI 10.1007/s11013-015-9434-y
PG 22
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA CI7QC
UT WOS:000354958100005
PM 25739529
ER
PT J
AU Fein, E
AF Fein, Elizabeth
TI Making Meaningful Worlds: Role-Playing Subcultures and the Autism
Spectrum
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Article
DE Autism; Asperger's syndrome; LARP; Neurodiversity
ID ASPERGER-SYNDROME; FUNCTIONING AUTISM; EXECUTIVE FUNCTION;
COGNITIVE-STYLE; DISORDERS; CHILDREN; INDIVIDUALS; COHERENCE; QUOTIENT;
DEFICITS
AB Every summer, a group of role-playing gamers gathers in an American town. Dressed up as moon goddesses, mad scientists, and other fantastical characters, they act out elaborate, improvised narratives of transformation, destruction, and redemption. For several summers, this group, who I call the Journeyfolk, ran a camp for teenagers on the autism spectrum, engaging campers in therapeutic reconfigurations of self and social role. Through this folk healing practice, the meaning of autism was itself transformed; what had been a source of isolation became a source of commonality and community. This paper takes the camp as a case study for examining the co-productive relationship between culture and neurodiversity. Cognitive tendencies often found in autism are often thought to preclude socio-cultural participation. However, such tendencies can also facilitate the co-creation of innovative cultural spaces, through processes of affinity and affiliation. Drawing on ethnographic fieldwork at the camp, I identify three sites of congruity between the culture of the camp and the cognitive and phenomenological experiences associated with autism, at which this "work of culture" (Obeysekere in The Work of Culture: Symbolic Transformation in Psychoanalysis and Anthropology, University of Chicago Press, Chicago, 1990) took place: the structure of social interactions within roleplaying games, the narratives enacted within these games, and the interpersonal relationships within which the games were embedded.
C1 Duquesne Univ, Dept Psychol, Pittsburgh, PA 15219 USA.
RP Fein, E (reprint author), Duquesne Univ, Dept Psychol, Pittsburgh, PA 15219 USA.
EM feine@duq.edu
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NR 55
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD JUN
PY 2015
VL 39
IS 2
SI SI
BP 299
EP 321
DI 10.1007/s11013-015-9443-x
PG 23
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA CI7QC
UT WOS:000354958100006
PM 25812848
ER
PT J
AU Fein, E
AF Fein, Elizabeth
TI Making Meaningful Worlds: Role-Playing Subcultures and the Autism
Spectrum (vol 39, pg 299, 2015)
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Correction
C1 Duquesne Univ, Dept Psychol, Pittsburgh, PA 15219 USA.
RP Fein, E (reprint author), Duquesne Univ, Dept Psychol, Pittsburgh, PA 15219 USA.
EM feine@duq.edu
CR Fein E, 2015, CULT MED PSYCHIAT, V39, P299, DOI 10.1007/s11013-015-9443-x
NR 1
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD JUN
PY 2015
VL 39
IS 2
SI SI
BP 322
EP 322
DI 10.1007/s11013-015-9454-7
PG 1
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA CI7QC
UT WOS:000354958100007
PM 25894003
ER
PT J
AU Solomon, O
AF Solomon, Olga
TI "But-He'll Fall!": Children with Autism, Interspecies Intersubjectivity,
and the Problem of 'Being Social'
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Article
DE Animal-assisted activity; Autism Spectrum Disorder; Human-animal
interaction; Intersubjectivity; Psychological testing; Sociality;
Therapy animals
ID SERVICE DOGS; THERAPY; EXPERIENCES; ENCOUNTERS; DISORDERS; FAMILIES;
BEHAVIOR; PEOPLE; WORLD
AB 'Being autistic' or 'having Autism Spectrum Disorder' implies a limited range of 'being social,' but the in situ organization of interaction, what Maynard and Marlaire (Qual Soc 15(2):177-202, 1992) call the 'interactional substrate,' within which this delimitation enfolds is usually hidden from sight. Analysis of processes constituting different 'interactional substrates' provides a view of how one comes to be known by and to self and others as a certain kind of being who is available (or not) for acting and feeling in certain ways. People diagnosed with Autism Spectrum Disorder (American Psychiatric Association, Diagnostic and statistical manual of mental disorders, 2013) are often described as 'being' impaired in intersubjective understanding of others. But the story of ASD as an impairment of sociality and intersubjectivity becomes more complicated when animals enter into the picture. I consider two interactional substrates: a psychological interview in a mental health clinic, and an animal-assisted activity in a child's neighborhood. I aim to elucidate the practical problems of 'being social' encountered by two children with ASD, both nine-year-old girls, within these two very differently organized interactional substrates. I consider ways in which 'being with' therapy animals provides a way of 'being social' through "sensory modalities of knowing" (Haraway, When species meet, 2008:371).
C1 Univ So Calif, USC Mrs TH Chan Div Occupat Sci & Occupat Therapy, Los Angeles, CA 90089 USA.
RP Solomon, O (reprint author), Univ So Calif, USC Mrs TH Chan Div Occupat Sci & Occupat Therapy, 1540 East Alcazar St,CHP 133, Los Angeles, CA 90089 USA.
EM olga.solomon@usc.edu
FU National Institute of Mental Health [R01 MH089474]; Cure Autism Now
foundation's Innovative Technology for Autism Bridge Grant; James H.
Zumberge Faculty Research and Innovation award; USC Mrs. T.H. Chan
Division of Occupational Science and Occupational Therapy
FX I am deeply grateful to the children and their families who participated
in this research, and to Susan Kraft, the animal trainer extraordinaire
who contributed her unique understanding of children with ASD. I would
be remiss not to thank the animals, those who participated in this
research and those who have taught me at different times about
interspecies intersubjectivity. An earlier version of this paper was
presented in June 2014 in a panel 'Interactional matrix of communication
in autism' organized by Laura Sterponi and John Rae at the International
Conference on Conversation Analysis at the University of California, Los
Angeles. I thank two anonymous reviewers, and Ariel Casio and Douglas
Maynard for their generous feedback on the final version. I also thank
my colleagues at the University of Southern California, Mary Lawlor,
Sharon Cermak, and Kate Crawley, and my academic 'family of origin' at
UCLA, Elinor Ochs, Alessandro Duranti, Marjory Harness Goodwin, and
Charles Goodwin for their encouragement of this research. The study
'Autism in Urban Context: Linking Heterogeneity with Health and Service
Disparities' was supported by the National Institute of Mental Health
(Grant # R01 MH089474, 2009-2012, O. Solomon, P.I.). The content of this
article is solely the responsibility of the author and does not
necessarily represent the official views of the National Institute of
Mental Health or the National Institutes of Health. The study
'Animal-Assisted Therapy as Socially Assistive Technology: Implications
for Autism' was supported by the Cure Autism Now foundation's Innovative
Technology for Autism Bridge Grant (2006-2007) and the James H. Zumberge
Faculty Research and Innovation award (2008). I am also deeply grateful
to the USC Mrs. T.H. Chan Division of Occupational Science and
Occupational Therapy that provided support for both studies.
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NR 91
TC 1
Z9 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD JUN
PY 2015
VL 39
IS 2
SI SI
BP 323
EP 344
DI 10.1007/s11013-015-9446-7
PG 22
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA CI7QC
UT WOS:000354958100008
PM 25926308
ER
PT J
AU Grinker, RR
AF Grinker, Roy Richard
TI Reframing the Science and Anthropology of Autism
SO CULTURE MEDICINE AND PSYCHIATRY
LA English
DT Editorial Material
C1 George Washington Univ, Dept Anthropol, Washington, DC 20052 USA.
RP Grinker, RR (reprint author), George Washington Univ, Dept Anthropol, Washington, DC 20052 USA.
EM rgrink@gwu.edu
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Ricoeur Paul, 2004, MEMORY HIST FORGETTI
Wilce JM, 2009, ANNU REV ANTHROPOL, V38, P199, DOI 10.1146/annurev-anthro-091908-164450
NR 10
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-005X
EI 1573-076X
J9 CULT MED PSYCHIAT
JI Cult. Med. Psychiatr.
PD JUN
PY 2015
VL 39
IS 2
SI SI
BP 345
EP 350
DI 10.1007/s11013-015-9444-9
PG 6
WC Anthropology; Psychiatry; Social Sciences, Biomedical
SC Anthropology; Psychiatry; Biomedical Social Sciences
GA CI7QC
UT WOS:000354958100009
PM 25792459
ER
PT J
AU Leaf, JB
Oppenheim-Leaf, ML
Leaf, RB
Taubman, M
McEachin, J
Parker, T
Waks, AB
Mountjoy, T
AF Leaf, Justin B.
Oppenheim-Leaf, Misty L.
Leaf, Ronald B.
Taubman, Mitchell
McEachin, John
Parker, Tracee
Waks, Andrea B.
Mountjoy, Toby
TI What is the Proof? A Methodological Review of Studies That Have Utilized
Social Stories
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Review
ID AUTISM SPECTRUM DISORDERS; DECREASING DISRUPTIVE BEHAVIORS;
ASPERGER-SYNDROME; CHILDREN; INTERVENTION; STUDENTS; IMPROVE; SKILLS;
SOCIAL-STORIES(TM); COMMUNICATION
AB Social stories are a commonly empirically evaluated and implemented procedure to increase pro-social behaviors and decrease aberrant behaviors for individuals diagnosed with an autism spectrum disorder. Despite their widespread use there have been questions raised to the soundness of the research methodology and the results which have been demonstrated within these research studies. This paper is a methodological review of 41 studies that evaluated social stories for individuals diagnosed with autism. We classified each study as one that utilized either a case study design, a reversal design, or a multiple baseline design. After classification we evaluated each study across multiple methodological dimensions and used this analysis to determine if a study showed either a clear demonstration, partial demonstration, or if there was no clear demonstration that the social story was responsible for behavior change. Results of this analysis indicated that the majority of studies either showed only a partial demonstration or no clear demonstration that the social story procedure was responsible for the behavior change. Based upon this analysis recommendations for clinicians and future researchers are discussed.
C1 [Leaf, Justin B.; Oppenheim-Leaf, Misty L.; Leaf, Ronald B.; Taubman, Mitchell; McEachin, John; Parker, Tracee; Waks, Andrea B.; Mountjoy, Toby] Autism Partnership Fdn, Seal Beach, CA 90740 USA.
RP Leaf, JB (reprint author), Autism Partnership Fdn, 200 Marina Dr, Seal Beach, CA 90740 USA.
EM Jblautpar@aol.com
CR Adams L., 2004, FOCUS AUTISM OTHER D, V19, P87, DOI DOI 10.1177/10883576040190020301
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NR 57
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2015
VL 50
IS 2
BP 127
EP 141
PG 15
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI8JX
UT WOS:000355019700001
ER
PT J
AU Cihak, DF
Wright, R
Smith, CC
McMahon, D
Kraiss, K
AF Cihak, David F.
Wright, Rachel
Smith, Cate C.
McMahon, Don
Kraiss, Kelly
TI Incorporating Functional Digital Literacy Skills as Part of the
Curriculum for High School Students with Intellectual Disability
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; SEVERE DEVELOPMENTAL-DISABILITIES;
GENERAL-EDUCATION CLASSROOM; HELD PROMPTING SYSTEM; MENTAL-RETARDATION;
TECHNOLOGY USE; TIME-DELAY; COMPUTER; INDIVIDUALS; CHILDREN
AB The purpose of this study was to examine the effects of teaching functional digital literacy skills to three high school students with intellectual disability. Functional digital literacy skills included sending and receiving email messages, organizing social bookmarking to save, share, and access career websites, and accessing cloud storage to download, revise, and upload documents. Results indicated that all students acquired and maintained these functional digital literacy skills. Findings are discussed in the context of teaching essential digital literacy skills to increase greater participation in a digital society.
C1 [Cihak, David F.; Wright, Rachel; Kraiss, Kelly] Univ Tennessee, Knoxville, TN 37996 USA.
[Smith, Cate C.] Appalachian State Univ, Boone, NC 28608 USA.
[McMahon, Don] Washington State Univ, Pullman, WA 99164 USA.
RP Cihak, DF (reprint author), Univ Tennessee, Coll Educ Hlth & Human Sci, A412 Bailey Educ Complex, Knoxville, TN 37996 USA.
EM dcihak@utk.edu
CR Alberto P. A., 2007, FOCUS AUTISM OTHER D, V22, P234, DOI DOI 10.1177/10883576070220040501
Ault M. J., 2013, TEACHING EXCEPTIONAL, V45, P46
Bawden D., 2008, DIGITAL LITERACIES C, P17
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Browder DM, 2011, EDUC TRAIN AUTISM DE, V46, P339
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Bryen DN, 2007, INTELLECT DEV DISAB, V45, P1, DOI 10.1352/1934-9556(2007)45[1:CPUBAW]2.0.CO;2
Burgstahler S., 2002, ADDRESSING TRENDS DE, V1, P1
Carey AC, 2005, MENT RETARD, V43, P322
Cihak D, 2010, J POSIT BEHAV INTERV, V12, P103, DOI 10.1177/1098300709332346
Cihak DF, 2007, RES DEV DISABIL, V28, P397, DOI 10.1016/j.ridd.2006.05.003
Cihak DF, 2008, EDUC TRAIN DEV DISAB, V43, P102
Cihak DF, 2010, EDUC TRAIN AUTISM DE, V45, P136
Clendon S, 2008, AUGMENT ALTERN COMM, V24, P281, DOI 10.1080/07434610802463999
Coleman MB, 2012, EDUC TRAIN AUTISM DE, V47, P280
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Cooney L., 2012, THINK COLL E NEWS
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Taber TA, 2003, RES PRACT PERS SEV D, V28, P105, DOI 10.2511/rpsd.28.3.105
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U. S. Census Bureau, 2010, AM DIS 2010
Wehmeyer M. L., 2004, Journal of Special Education Technology, V19
NR 49
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2015
VL 50
IS 2
BP 155
EP 171
PG 17
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI8JX
UT WOS:000355019700003
ER
PT J
AU Barnett, JEH
Cleary, S
AF Barnett, Juliet E. Hart
Cleary, Shannon
TI Review of Evidence-based Mathematics Interventions for Students with
Autism Spectrum Disorders
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Review
ID HIGH-FUNCTIONING AUTISM; MODERATE INTELLECTUAL DISABILITIES;
LOW-ACHIEVING STUDENTS; TEACH ADDITION FACTS; ASPERGER-SYNDROME;
STRATEGY INSTRUCTION; SCHOOL-STUDENTS; WORD-PROBLEMS; CHILDREN; SKILLS
AB Students with autism spectrum disorders (ASD) are being included more frequently in the general educational setting, and are therefore increasingly expected to access and master core curricular content, including mathematics. However, mathematics often presents challenges to students with ASD. Interventions to improve the mathematics skills of students with ASD have been recommended. This comprehensive literature review synthesized eleven studies of mathematics intervention strategies for students with ASD. Though studies related to instructional interventions in mathematics for students with ASD are limited, these students can benefit from mathematics interventions, which can help them strengthen their mathematics skills, increase independence when completing problems, and use acquired skills in community or other applied settings. Future implications include the need for additional, empirically-supported interventions in mathematics for students with ASD and the need to target more academically-oriented math interventions for this population, particularly in the context of problem solving, which will assist in determining the potential of students with ASD to achieve mathematic success.
C1 [Barnett, Juliet E. Hart; Cleary, Shannon] Arizona State Univ, Phoenix, AZ 85069 USA.
RP Barnett, JEH (reprint author), Arizona State Univ, Mary Lou Fulton Teachers Coll, POB 37100,Mail Code 3151, Phoenix, AZ 85069 USA.
EM Juliet.Hart@asu.edu
CR Baker S, 2002, ELEM SCHOOL J, V103, P51, DOI 10.1086/499715
Banda D. R., 2010, PREVENTING SCH FAILU, V54, P81
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National Council of Teachers of Mathematics, 2002, PRINC STAND SCH MATH
Odom SL, 2005, EXCEPT CHILDREN, V71, P137
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Whitby PJS, 2013, FOCUS AUTISM DEV DIS, V28, P78, DOI 10.1177/1088357612468764
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NR 42
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2015
VL 50
IS 2
BP 172
EP 185
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI8JX
UT WOS:000355019700004
ER
PT J
AU Leaf, JB
Leaf, R
Alcalay, A
Leaf, JA
Ravid, D
Dale, S
Kassardjian, A
Tsuji, K
Taubman, M
McEachin, J
Oppenheim-Leaf, M
AF Leaf, Justin B.
Leaf, Ronald
Alcalay, Aditt
Leaf, Jeremy A.
Ravid, Daniel
Dale, Stephanie
Kassardjian, Alyne
Tsuji, Kathleen
Taubman, Mitchell
McEachin, John
Oppenheim-Leaf, Misty
TI Utility of Formal Preference Assessments for Individuals Diagnosed with
Autism Spectrum Disorder
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID IDENTIFYING REINFORCERS; CHILDREN; BEHAVIOR; STIMULUS
AB The systematic use of reinforcers is an essential component of behavioral intervention for individuals diagnosed with Autism Spectrum Disorder. Today, the use of rigorous formal preference assessments, including paired-preference assessments, are widely conducted to help determine which items to use as reinforcers during intervention. Although paired-preference assessments are widely used there is no experimental evidence whether extensive advance sampling actually produces higher rates of responding compared to in-the-moment analysis of reinforcer effects. The present study compared the rate of responding on a simple sorting task when participants were provided items that were determined as preferred via an extensive paired preference assessment to a teacher selecting items without the use of a paired preference assessment, but rather with an in-the-moment analysis of reinforcer effects. The results indicated no clear difference in the rate of responding, but there were clear differences in terms of efficiency. Clinical implications will be discussed.
C1 [Leaf, Justin B.] Autism Partnership Fdn, Seal Beach, CA 90740 USA.
Behav Therapy & Learning Ctr, Calgary, AB, Canada.
RP Leaf, JB (reprint author), Autism Partnership Fdn, 200 Marina Dr, Seal Beach, CA 90740 USA.
EM Jblautpar@aol.com
CR Ayllon T., 1965, TOKEN EC MOTIVATIONA
Cooper J. O., 2007, APPL BEHAV ANAL, V2nd, P575
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NR 16
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2015
VL 50
IS 2
BP 199
EP 212
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI8JX
UT WOS:000355019700006
ER
PT J
AU Rosenberg, N
Congdon, M
Schwartz, I
Kamps, D
AF Rosenberg, Nancy
Congdon, Marissa
Schwartz, Ilene
Kamps, Debra
TI Use of Say-Do Correspondence Training to Increase Generalization of
Social Interaction Skills at Recess for Children with Autism Spectrum
Disorder
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID HIGH-FUNCTIONING CHILDREN; INTERVENTIONS; EDUCATION; BEHAVIOR; PROGRAM
AB Research suggests that while social skills groups in school settings can be effective for students with Autism Spectrum Disorder (ASD), generalization of the skills and behaviors learned in these groups to other settings can be problematic. This study assessed the use of a say-do correspondence intervention to increase generalization at recess of social interactions skills previously learned in a social skills group for students with ASD. The participants were three first graders who had participated in intensive social skills instruction for over a year but who were not generalizing their acquired skills to recess. The say-do correspondence involved the participants identifying before recess who they were going to talk to at recess and then receiving access to reinforcers after recess if they had talked to the student they had identified. A multiple-baseline across participants design was used to assess the impact of the intervention on the number of social exchanges between the child with ASD and other children during recess. Results showed that the number of social exchanges increased for all participants. Implications for practice in public school settings are discussed.
C1 [Rosenberg, Nancy; Congdon, Marissa; Schwartz, Ilene] Univ Washington, Seattle, WA 98195 USA.
[Kamps, Debra] Univ Kansas, Lawrence, KS 66045 USA.
RP Rosenberg, N (reprint author), Univ Washington, Haring Ctr, Box 357925, Seattle, WA 98195 USA.
EM nancyr@uw.edu
FU Institute of Education Sciences, Department of Education [R324A090091]
FX The research was funded by the Institute of Education Sciences,
Department of Education (R324A090091). Opinions expressed herein are
those of the authors and do not necessarily reflect the position of the
funding agency.
CR Ballard K. D., 1981, EXCEPT CHILDREN, V28, P55, DOI [10.1080/0156655810280106, DOI 10.1080/0156655810280106]
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Giangreco MF, 1997, EXCEPT CHILDREN, V64, P7
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GUEVREMONT DC, 1986, J APPL BEHAV ANAL, V19, P99, DOI 10.1901/jaba.1986.19-99
Kamps D., 2014, J AUTISM DEV DISORD, V44, P1
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Lang R, 2011, RES AUTISM SPECT DIS, V5, P1296, DOI 10.1016/j.rasd.2011.02.012
Lee S. H., 2007, FOCUS AUTISM OTHER D, V22, P2, DOI DOI 10.1177/10883576070220010101
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National Professional Development Center on Autism Spectrum Disorders, EV BAS PRACT
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NR 26
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2015
VL 50
IS 2
BP 213
EP 222
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI8JX
UT WOS:000355019700007
ER
PT J
AU Stroizer, S
Hinton, V
Flores, M
Terry, L
AF Stroizer, Shaunita
Hinton, Vanessa
Flores, Margaret
Terry, LaTonya
TI An Investigation of the Effects of CRA Instruction and Students with
Autism Spectrum Disorder
SO EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID CHILDREN
AB Students with Autism Spectrum Disorders (ASD) have unique educational needs. The concrete representational abstract (CRA) instructional sequence has been shown effective in teaching students with mathematical difficulties. The purpose of this study was to examine the effects of the CRA sequence in teaching students with ASD. A multiple baseline across behavior design was used in assessing the effects of CRA to three elementary students with ASD over four weeks of instruction. A functional relation was demonstrated between CRA and three behaviors: addition with regrouping, subtraction with regrouping, and the multiplication facts zero through five. The results and implications are discussed further.
C1 [Stroizer, Shaunita] Valdosta State Univ, Valdosta, GA USA.
[Hinton, Vanessa; Flores, Margaret; Terry, LaTonya] Auburn Univ, Auburn, AL 36849 USA.
RP Hinton, V (reprint author), Auburn Univ, Dept Special Educ Rehabil & Counseling, Haley Ctr 2084, Auburn, AL 36849 USA.
EM vmh0002@tigermail.auburn.edu
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
Boutot E. A., 2011, AUTISM SPECTRUM DISO
Butler F. M., 2003, LEARNING DISABILITIE, V18, P99, DOI DOI 10.1111/1540-5826.00066
Centers for Disease Control and Prevention, 2012, PREV OF ASDS
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Donaldson J. B., 2010, TEACHING EXCEPTIONAL, V42, P40
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National Autism Center, 2009, EV BAS PRACT AUT SCH
National Council of Teachers of Mathematics, 2000, PRINC STAND SCH MATH
National Council of Teachers of Mathematics, 2006, CURR FOC POINTS PREK
National Governors Association Center for Best Practices & the Council of Chief State School Officers, 2010, KEY SHIFTS MATH
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U.S. Department of Education, 2002, NO CHILD LEFT DESKT
Witzel B. S., 2003, LEARNING DISABILITIE, V3, P49, DOI DOI 10.1111/1540-5826.00068
NR 30
TC 0
Z9 0
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 2154-1647
J9 EDUC TRAIN AUTISM DE
JI Educ. Train. Autism Dev. Disabil.
PD JUN
PY 2015
VL 50
IS 2
BP 223
EP 236
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI8JX
UT WOS:000355019700008
ER
PT J
AU Ulke-Kurkcuoglu, B
Bozkurt, F
Cuhadar, S
AF Ulke-Kurkcuoglu, Burcu
Bozkurt, Funda
Cuhadar, Selmin
TI Effectiveness of Instruction Performed through Computer-Assisted
Activity Schedules on On-Schedule and Role-Play Skills of Children with
Autism Spectrum Disorder
SO EDUCATIONAL SCIENCES-THEORY & PRACTICE
LA English
DT Article
DE Autism spectrum disorder; Activity schedules; Role-play skills; Computer
assisted; On-schedule
ID PHOTOGRAPHIC ACTIVITY SCHEDULES; PRETEND PLAY; CHALLENGING BEHAVIOR;
INCREASING PLAY; LEISURE SKILLS; DISABILITIES; ENGAGEMENT; TASK;
CLASSROOM
AB This study aims to investigate the effectiveness of the instruction process provided through computer-assisted activity schedules in the instruction of on-schedule and role-play skills to children with autism spectrum disorder. Herein, a multiple probe design with probe conditions across participants among single subject designs was used. Four children aged between four and ten participated in the study. The findings of the study showed that the instruction process provided through computer-assisted activity schedules has an effect upon the acquisition, maintenance, and generalization of the on-schedule and role-play skills of the children participating in the study. With respect to the social validity findings of the study, families and teachers gave positive opinions about the instruction process. In this paper, the findings obtained from the study are discussed and suggestions are made regarding implications and future research.
C1 [Ulke-Kurkcuoglu, Burcu] Anadolu Univ, Res Inst Handicapped, TR-26470 Eskisehir, Turkey.
[Bozkurt, Funda] Anadolu Univ, Fac Educ, Dept Special Educ, TR-26470 Eskisehir, Turkey.
[Cuhadar, Selmin] Trakya Univ, Fac Educ, Dept Special Educ, Edirne, Turkey.
RP Ulke-Kurkcuoglu, B (reprint author), Anadolu Univ, Res Inst Handicapped, Yunus Emre Campus, TR-26470 Eskisehir, Turkey.
EM bulkekurkcuoglu@anadolu.edu.tr; fundab@anadolu.edu.tr;
selmincuhadar@trakya.edu.tr
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Banda DR, 2008, EDUC TRAIN DEV DISAB, V43, P324
Barton E. E., 2012, YOUNG EXCEPTIONAL CH, V15, P5
Barton EE, 2010, INFANT YOUNG CHILD, V23, P247, DOI 10.1097/IYC.0b013e3181f22072
Barton EE, 2008, TOP EARLY CHILD SPEC, V28, P109, DOI 10.1177/0271121408318799
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BILLINGSLEY F, 1980, BEHAV ASSESS, V2, P229
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Carlile KA, 2013, EDUC TREAT CHILD, V36, P33
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Cuhadar S, 2011, EDUC TRAIN AUTISM DE, V46, P386
Dauphin M, 2004, J POSIT BEHAV INTERV, V6, P238, DOI 10.1177/10983007040060040501
Haney M. R., 2013, UNDERSTANDING CHILDR
Hobson JA, 2013, BRIT J DEV PSYCHOL, V31, P114, DOI 10.1111/j.2044-835X.2012.02083.x
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Kimball J., 2004, ED TREATMENT CHILDRE, V27, P280
Kircaali-Iftar G., 2012, OTIZM SPEKTRUM BOZUK, P17
Kircaali-Iftar G., 2007, OTIZM SPEKTRUM BOZUK
Koroglu E., 2001, PSIK HAST TAN SIN KI
Koyama T, 2011, RES DEV DISABIL, V32, P2235, DOI 10.1016/j.ridd.2011.05.003
KRANTZ PJ, 1993, J APPL BEHAV ANAL, V26, P137, DOI 10.1901/jaba.1993.26-137
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Liber DB, 2008, J AUTISM DEV DISORD, V38, P312, DOI 10.1007/s10803-007-0395-z
Lifter K, 2011, INFANT YOUNG CHILD, V24, P225, DOI 10.1097/IYC.0b013e31821e995c
Lovaas O. I., 2003, TEACHING INDIVIDUALS
MACDUFF GS, 1993, J APPL BEHAV ANAL, V26, P89, DOI 10.1901/jaba.1993.26-89
Machalicek W, 2009, RES AUTISM SPECT DIS, V3, P547, DOI 10.1016/j.rasd.2008.11.003
Massey NG, 2000, EDUC TRAIN MENT RET, V35, P326
McClannahan L. E., 1999, ACTIVITY SCHEDULES C
Morrison RS, 2002, J EARLY INTERVENTION, V25, P58, DOI 10.1177/105381510202500106
Naber FBA, 2008, J AUTISM DEV DISORD, V38, P857, DOI 10.1007/s10803-007-0454-5
Penington R. C., 2010, FOCUS AUTISM OTHER D, V25, P239
Phillips N., 2012, TEACHING PLAY CHILDR, V2nd
Pierce JM, 2013, INT J DISABIL DEV ED, V60, P253, DOI 10.1080/1034912X.2013.812191
Rehfeldt RA, 2004, J APPL BEHAV ANAL, V37, P115, DOI 10.1901/jaba.2004.37-115
Rutherford MD, 2007, J AUTISM DEV DISORD, V37, P1024, DOI 10.1007/s10803-006-0240-9
Stromer R., 2006, FOCUS AUTISM OTHER D, V21, P14, DOI 10.1177/10883576060210010301
Tawney J. W., 1984, SINGLE SUBJECT RES S
Tekin-Iftar E., 2006, OZEL EGITIMDE YANLIS, V2nd
Tekin-Iftar E., 2012, EGITIM DAVRANIS BILI, P217
Wolfberg P. J., 1999, PLAY IMAGINATION CHI
Wong C., 2014, EVIDENCE BASED PRACT
NR 43
TC 0
Z9 0
PU EDAM
PI ISTANBUL
PA KISIKLI MH ALEMDAG CD YAN YOL SK, SBK IS MERKEZI NO 5, KAT 1 USKUDAR,
ISTANBUL, 81190, TURKEY
SN 1303-0485
EI 2148-7561
J9 EDUC SCI-THEOR PRACT
JI Educ. Sci.-Theory Pract.
PD JUN
PY 2015
VL 15
IS 3
BP 671
EP 689
PG 19
WC Education & Educational Research
SC Education & Educational Research
GA CI2VK
UT WOS:000354605300010
ER
PT J
AU Akmanoglu, N
Kurt, O
Kapan, A
AF Akmanoglu, Nurgul
Kurt, Onur
Kapan, Alper
TI Comparison of Simultaneous Prompting and Constant Time Delay Procedures
in Teaching Children with Autism the Responses to Questions about
Personal Information
SO EDUCATIONAL SCIENCES-THEORY & PRACTICE
LA English
DT Article
DE Autism spectrum disorder; Errorless teaching; Simultaneous prompting;
Constant time delay
ID SKILLS; DISABILITIES; RETARDATION
AB The aim of the current study was to compare simultaneous prompting (SP) and constant time delay (CTD) in terms of their effectiveness and efficiency in teaching children with autism how to respond to questions about personal information. The adapted alternating treatments model was used in the study. Three male students with autism aged 4, 6, and 9, respectively, were included in the study. The findings of the study did not indicate any significant difference in two students with respect to the effectiveness of SP and CTD procedures. On the other hand, SP was observed to create more positive results and lead to a higher level of learning for the third participant. According to the findings, SP was more effective for one participant with respect to all the parameters studied. While SP was more efficient in the other two subjects in terms of incorrect responses, the difference regarding the instructional time to criterion for these two subjects was at a minimal level in favor of SP.
C1 [Akmanoglu, Nurgul; Kurt, Onur; Kapan, Alper] Anadolu Univ, Res Inst Individuals Disabil, Eskisehir, Turkey.
RP Kurt, O (reprint author), Anadolu Univ, Res Inst Individuals Disabil, Eskisehir, Turkey.
EM nakmanoglu@anadolu.edu.tr; onurk@anadolu.edu.tr; akapan@anadolu.edu.tr
CR Akmanoglu N, 2004, EDUC TRAIN DEV DISAB, V39, P326
Akmanoglu-Uludag N., 2005, EDUC TRAIN DEV DISAB, V40, P401
BILLINGSLEY F, 1980, BEHAV ASSESS, V2, P229
Bozkurt F, 2005, EDUC TRAIN DEV DISAB, V40, P390
Browder D. M., 2000, INSTRUCTION 7 DISABI, V5th, P453
Dippi-Hoy C., 2004, J SPEC EDUC, V38, P144
Dogoe M, 2009, EDUC TRAIN DEV DISAB, V44, P177
Fetko KS, 1999, EDUC TRAIN MENT RET, V34, P318
Gast D. L., 2010, SINGLE SUBJECT RES M
GAST DL, 1988, EDUC TRAIN MENT RET, V23, P117
GIBSON AN, 1992, TOP EARLY CHILD SPEC, V12, P247
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Horner RH, 2005, EXCEPT CHILDREN, V71, P165
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NR 39
TC 0
Z9 0
PU EDAM
PI ISTANBUL
PA KISIKLI MH ALEMDAG CD YAN YOL SK, SBK IS MERKEZI NO 5, KAT 1 USKUDAR,
ISTANBUL, 81190, TURKEY
SN 1303-0485
EI 2148-7561
J9 EDUC SCI-THEOR PRACT
JI Educ. Sci.-Theory Pract.
PD JUN
PY 2015
VL 15
IS 3
BP 723
EP 737
PG 15
WC Education & Educational Research
SC Education & Educational Research
GA CI2VK
UT WOS:000354605300013
ER
PT J
AU Skaper, SD
Facci, L
Fusco, M
della Valle, MF
Zusso, M
Costa, B
Giusti, P
AF Skaper, Stephen D.
Facci, Laura
Fusco, Mariella
della Valle, Maria Federica
Zusso, Morena
Costa, Barbara
Giusti, Pietro
TI Reply to: "Palmitoylethanolamide: problems regarding micronization,
ultra-micronization and additives" Inflammopharmacology
DOI:10.1007/s10787-014-0202-3
SO INFLAMMOPHARMACOLOGY
LA English
DT Editorial Material
DE Neuropathic pain; Palmitoylethanolamide; Micronization; Excipients
ID AUTISM SPECTRUM DISORDERS; 2-ARACHIDONOYLGLYCEROL; FORMULATION;
LUTEOLIN; CHILDREN
AB This is a reply to a recently published Commentary: "Palmitoylethanolamide: problems regarding micronization, ultra-micronization and additives" Inflammopharmacology DOI:10.1007/s10787-014-0202-3RefTarget Address="10.1007/s10787-014-0202-3" TargetType="DOI", written in relation to our review article: Skaper SD, Facci L, Fusco M, della Valle MF, Zusso M, Costa B, Giusti P (2014) "Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain" Inflammopharmacology 22:79-94 DOI:10.1007/s10787-013-0191-7RefTarget Address="10.1007/s10787-013-0191-7" TargetType="DOI". We believe that the Commentary by Kriek contains a number of erroneous statements and misinterpretations of the published scientific/medical literature which our reply shall elaborate on. Further, the writer of the Commentary has a direct connection to a company, JP Russell Science Ltd that sells palmitoylethanolamide. The take-home message of our review remains as originally stated: "Collectively, the findings presented here propose that palmitoylethanolamide merits further consideration as a disease-modifying agent for controlling inflammatory responses and related chronic and neuropathic pain".
C1 [Skaper, Stephen D.; Facci, Laura; Zusso, Morena; Giusti, Pietro] Univ Padua, Padua, Italy.
[Fusco, Mariella] Epitech Grp Srl, Sci Informat & Documentat Ctr, Saccolongo, PD, Italy.
[della Valle, Maria Federica] Innovet Italia Srl, CeDIS Sci Informat & Documentat Ctr, Saccolongo, PD, Italy.
[Costa, Barbara] Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy.
RP Skaper, SD (reprint author), Univ Padua, Padua, Italy.
EM stephen.skaper@unipd.it
CR Airaksinen Sari, 2005, AAPS PharmSciTech, V6, pE311, DOI 10.1208/pt060241
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World Health Organization, 2009, CALC MAGN DRINK WAT
NR 18
TC 0
Z9 0
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD JUN
PY 2015
VL 23
IS 2-3
BP 127
EP 130
DI 10.1007/s10787-014-0208-x
PG 4
WC Immunology; Pharmacology & Pharmacy; Toxicology
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA CI5TH
UT WOS:000354822200007
PM 24862356
ER
PT J
AU Lundstrom, S
Reichenberg, A
Melke, J
Rastam, M
Kerekes, N
Lichtenstein, P
Gillberg, C
Anckarsater, H
AF Lundstrom, Sebastian
Reichenberg, Abraham
Melke, Jonas
Rastam, Maria
Kerekes, Nora
Lichtenstein, Paul
Gillberg, Christopher
Anckarsater, Henrik
TI Autism spectrum disorders and coexisting disorders in a nationwide
Swedish twin study
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorders; comorbidity; genetics; twins
ID DE-NOVO MUTATIONS; A-TAC; TELEPHONE INTERVIEW; CHILDHOOD; CHILDREN;
ASSOCIATION; SAMPLE; CONTACTIN-ASSOCIATED-PROTEIN-LIKE-2; MICRODELETION;
INTERVENTION
AB BackgroundEvidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort.
MethodsParents of all Swedish 9-year-old twins born between 1992 and 2001 (n=19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins.
ResultsHalf of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The healthy co-twin' in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females).
ConclusionsDetailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically.
C1 [Lundstrom, Sebastian; Kerekes, Nora; Anckarsater, Henrik] Univ Gothenburg, Ctr Eth Law & Mental Hlth, S-43141 Molndal, Sweden.
[Lundstrom, Sebastian; Gillberg, Christopher] Univ Gothenburg, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
[Lundstrom, Sebastian; Kerekes, Nora] Swedish Prison & Probat Serv, R&D Unit, Gothenburg, Sweden.
[Reichenberg, Abraham] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
[Reichenberg, Abraham] Mt Sinai Sch Med, Dept Prevent Med, New York, NY USA.
[Melke, Jonas] Univ Gothenburg, Dept Pharmacol, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden.
[Rastam, Maria] Lund Univ, Dept Clin Sci Child & Adolescent Psychiat, Lund, Sweden.
[Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
RP Lundstrom, S (reprint author), Univ Gothenburg, Ctr Eth Law & Mental Hlth, Wallins Gatan 8, S-43141 Molndal, Sweden.
EM sebastian.lundstrom@neuro.gu.se
FU Swedish Council for Working Life; Research Council of the Swedish
National Alcohol Monopoly; Soderstrom-Konigska Foundation; ALF; Swedish
Research Council
FX The CATSS study was supported by the Swedish Council for Working Life,
the Research Council of the Swedish National Alcohol Monopoly,
Soderstrom-Konigska Foundation, and the funds under the ALF agreement
and the Swedish Research Council. The funding sources had no involvement
in study design, collection, analysis, interpretation of the data, and
were not involved in the decision to submit this paper for publication.
The authors have declared that they have no competing or potential
conflicts of interest.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Anckarsater H, 2011, TWIN RES HUM GENET, V14, P495, DOI 10.1375/twin.14.6.495
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Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7
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Ben-Itzchak E, 2007, RES DEV DISABIL, V28, P287, DOI 10.1016/j.ridd.2006.03.002
Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078
Coleman M., 2012, THE AUTISMS
Cubo E, 2011, AN PEDIATR, V75, P40, DOI 10.1016/j.anpedi.2011.01.008
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NR 40
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD JUN
PY 2015
VL 56
IS 6
BP 702
EP 710
DI 10.1111/jcpp.12329
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA CI0XY
UT WOS:000354464300011
PM 25279993
ER
PT J
AU Helles, A
Gillberg, CI
Gillberg, C
Billstedt, E
AF Helles, Adam
Gillberg, Carina I.
Gillberg, Christopher
Billstedt, Eva
TI Asperger syndrome in males over two decades: stability and predictors of
diagnosis
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Asperger syndrome; diagnostic stability; autism spectrum disorder;
pervasive developmental disorder; males; longitudinal study
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM; DSM-IV-TR;
CHILDHOOD; CHILDREN; SYMPTOMS; CRITERIA; ADULTS; INDIVIDUALS;
ADOLESCENCE
AB ObjectiveTo examine the diagnostic stability of a childhood diagnosis of Asperger Syndrome (AS) into adulthood in a prospective longitudinal study, and identify the predictors of stability.
MethodsOne hundred males with AS diagnosed in childhood (T0) according to Gillberg's AS criteria, were followed up prospectively into adulthood over an average of 19years (range 13-26years). Fifty males (mean age 30years) participated in this second follow-up (T2) of the cohort. Seventy-six had participated in a previous follow-up (T1) at mean age 22years (47 participated in both follow-ups). Diagnosis at T2 was assessed using three sets of diagnostic criteria (Gillberg's AS criteria, DSM-IV Pervasive Developmental Disorder (PDD) and DSM-5 Autism Spectrum Disorder (ASD) criteria) and compared to previous assessments. Background predictors of diagnostic stability were analyzed. General functioning at T2 was assessed and compared to T1.
ResultsThere was a decline in the stability of AS diagnosis over time, the rate dropping from 82% at T1 to 44% at T2, when using the Gillberg criteria. There was also a significant decrease in the rate of cases fulfilling any PDD diagnosis according to the DSM-IV, from 91% at T1 to 76% at T2 in the 47 cases followed up twice. Severity of autism spectrum symptoms at T1 was the main predictor of diagnostic stability at T2. Twenty percent of those meeting criteria for a PDD diagnosis according to DSM-IV, did not meet DSM-5 ASD criteria although they had marked difficulties in everyday life.
ConclusionAsperger Syndrome, when considered as an ASD/PDD diagnosis, was fairly stable into adulthood, but there was a significant increase over time in cases no longer meeting criteria for an ASD diagnosis according to the DSM-IV, or AS according to the Gillberg criteria. Cases with a stable diagnosis showed significantly more core ASD symptoms in adolescence/young adulthood.
C1 [Helles, Adam; Gillberg, Carina I.; Gillberg, Christopher; Billstedt, Eva] Gothenburg Univ, Gillberg Neuropsychiat Ctr, Inst Neurosci & Physiol, Sahlgrenska Acad, S-41119 Gothenburg, Sweden.
RP Helles, A (reprint author), Gothenburg Univ, Gillberg Neuropsychiat Ctr, Kungsgatan 12, S-41119 Gothenburg, Sweden.
EM adam.helles@gnc.gu.se
FU Centre for Research and Development in Gavleborg; Child and Adolescent
Habilitation Clinic in Gavle; VG Region Scientific Fund; Jerring Fund;
Wilhelm and Martina Lundgren Foundation; Petter Silfverskiold
Foundation; Golje Foundation; AnnMarie and Per Ahlqvist Foundation;
Swedish Child Neuropsychiatry Science Foundation; Gillberg
Neuropsychiatry Centre
FX The study was supported by funding from: Centre for Research and
Development in Gavleborg and the Child and Adolescent Habilitation
Clinic in Gavle, VG Region Scientific Fund, the Jerring Fund, Wilhelm
and Martina Lundgren Foundation, Petter Silfverskiold Foundation, Golje
Foundation, AnnMarie and Per Ahlqvist Foundation, the Swedish Child
Neuropsychiatry Science Foundation, and the Gillberg Neuropsychiatry
Centre. The authors have declared that they have no potential or
competing conflicts of interest.
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709
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Wechsler D., 1974, MANUAL WECHSLER INTE
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NR 40
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD JUN
PY 2015
VL 56
IS 6
BP 711
EP 718
DI 10.1111/jcpp.12334
PG 8
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA CI0XY
UT WOS:000354464300012
PM 25283685
ER
PT J
AU Zuckerman, KE
Lindly, OJ
Sinche, BK
AF Zuckerman, Katharine Elizabeth
Lindly, Olivia Jasmine
Sinche, Brianna Kathleen
TI Parental Concerns, Provider Response, and Timeliness of Autism Spectrum
Disorder Diagnosis
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID UNITED-STATES; DEVELOPMENTAL CONCERNS; IDENTIFY CHILDREN; MEDICAL HOME;
CARE; AGE; FAMILIES; SERVICES; DISPARITIES; RISK
AB Objectives To assess differences between child age at first parental concern and age at first parental discussion of concerns with a health care provider among children with autism spectrum disorder (ASD) vs those with intellectual disability/developmental delay (ID/DD), and to assess whether provider response to parental concerns is associated with delays in ASD diagnosis.
Study design Using nationally representative data from the 2011 Survey of Pathways to Diagnosis and Treatment, we compared child age at parent's first developmental concern with age at first discussion of concerns with a provider, and categorized provider response as proactive or reassuring/passive, among 1420 children with ASD and 2098 children with ID/DD. In the children with ASD, we tested the association between provider response type and years of diagnostic delay.
Results Compared with children with ID/DD, children with ASD were younger when parents first had concerns and first discussed those concerns with a provider. Compared with parents of children with ID/DD, parents of children with ASD were less likely to receive proactive responses to their concerns and more likely to receive reassuring/passive responses. Among children with ASD, those with more proactive provider responses to concerns had shorter delays in ASD diagnosis compared with those with passive/reassuring provider responses.
Conclusion Although parents of children with ASD have early concerns, delays in diagnosis are common, particularly when providers' responses are reassuring or passive, highlighting the need for targeted improvements in primary care.
C1 [Zuckerman, Katharine Elizabeth; Lindly, Olivia Jasmine; Sinche, Brianna Kathleen] Oregon Hlth & Sci Univ, Doernbecher Childrens Hosp, Div Gen Pediat, Portland, OR 97239 USA.
[Lindly, Olivia Jasmine] Oregon State Univ, Sch Publ Hlth, Corvallis, OR 97331 USA.
RP Zuckerman, KE (reprint author), Oregon Hlth & Sci Univ, CDRC 3203,707 SW Gaines Rd, Portland, OR 97239 USA.
EM zuckerma@ohsu.edu
FU Medical Research Foundation of Oregon; National Institute of Mental
Health [1K23MH095828]
FX Funded by the Medical Research Foundation of Oregon. K.Z. was funded by
the National Institute of Mental Health (1K23MH095828). The authors
declare no conflicts of interest.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Autism, 2012, MMWR-MORBID MORTAL W, V61, P1
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NR 53
TC 0
Z9 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD JUN
PY 2015
VL 166
IS 6
BP 1431
EP +
DI 10.1016/j.jpeds.2015.03.007
PG 10
WC Pediatrics
SC Pediatrics
GA CI8JI
UT WOS:000355018200022
PM 25888348
ER
PT J
AU Kirsten, TB
Queiroz-Hazarbassanov, N
Bernardi, MM
Felicio, LF
AF Kirsten, Thiago B.
Queiroz-Hazarbassanov, Nicolle
Bernardi, Maria M.
Felicio, Luciano F.
TI Prenatal zinc prevents communication impairments and BDNF disturbance in
a rat model of autism induced by prenatal lipopolysaccharide exposure
SO LIFE SCIENCES
LA English
DT Article
DE Autistic-like effects; Maternal immune activation; Prenatal infection;
Ultrasonic vocalizations; Gestation
ID DEFICIT HYPERACTIVITY DISORDER; NEUROTROPHIC FACTOR; SPECTRUM DISORDERS;
ULTRASONIC VOCALIZATION; INDUCED TERATOGENICITY; MATERNAL SEPARATION;
MENTAL-RETARDATION; IMMUNE CHALLENGE; AMNIOTIC-FLUID; PROTEIN-LEVELS
AB Aims: Previous investigations by our group have shown that prenatal exposure to lipopolysaccharide (LPS), which mimics infections by Gram-negative bacteria, induced autistic-like behavior. No effective treatment yet exists for autism. Therefore, we used our rat model to test a possible treatment for autism. We selected zinc as the prenatal treatment to prevent or ease the impairments induced by LPS because LPS induces hypozincaemia.
Materials and methods: We evaluated the effects of LPS and zinc on female reproductive performance. Communication, which is impaired in autism, was tested in pups by ultrasonic vocalizations. Plasma levels of brain-derived neurotrophic factor (BDNF) were determined because it has been considered an autism important biomarker.
Key findings: Prenatal LPS exposure reduced offspring number and treatment with zinc prevented this reduction. Moreover, pups that were prenatally exposed to LPS spent longer periods without calling their mothers, and posttreatment with zinc prevented this impairment induced by LPS to the same levels as controls. Prenatal LPS also increased BDNF levels in adult offspring, and posttreatment with zinc reduced the elevation of BDNF to the same levels as controls.
Significance: BDNF hyperactivity was also found in several studies of autistic patients. Together with our previous studies, our model of prenatal LPS induced autistic-like behavioral, brain, and immune disturbances. This suggests that it is a valid rat model of autism. Prenatal zinc prevented reproductive, communication, and BDNF impairments. The present study revealed a potential beneficial effect of prenatal zinc administration for the prevention of autism with regard to the BDNF pathway. (c) 2015 Elsevier Inc. All rights reserved.
C1 [Kirsten, Thiago B.; Queiroz-Hazarbassanov, Nicolle; Felicio, Luciano F.] Univ Sao Paulo, Dept Pathol, Sch Vet Med, BR-05508270 Sao Paulo, SP, Brazil.
[Kirsten, Thiago B.; Bernardi, Maria M.] Univ Estadual Paulista, Environm & Expt Pathol, BR-04026002 Sao Paulo, SP, Brazil.
RP Kirsten, TB (reprint author), Univ Sao Paulo, Dept Pathol, Sch Vet Med, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP, Brazil.
EM thik@outlook.com
FU Sao Paulo Research Foundation (FAPESP) [2012/07007-8]; Sao Paulo
Research Foundation [2009/51886-3]; Coordenacao de Aperfeicoamento de
Pessoal de Nivel Superior [CAPES/Premio 1029/2014]
FX This research was supported by the Sao Paulo Research Foundation (FAPESP
grant 2012/07007-8 and thematic grant 2009/51886-3) and the Coordenacao
de Aperfeicoamento de Pessoal de Nivel Superior (CAPES/Premio
1029/2014).
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NR 71
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 1
PY 2015
VL 130
BP 12
EP 17
DI 10.1016/j.lfs.2015.02.027
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CI4XC
UT WOS:000354756200003
PM 25817235
ER
PT J
AU Kiep, M
Spek, AA
Hoeben, L
AF Kiep, Michelle
Spek, Annelies A.
Hoeben, Lisette
TI Mindfulness-Based Therapy in Adults with an Autism Spectrum Disorder: Do
Treatment Effects Last?
SO MINDFULNESS
LA English
DT Article
DE ASD; Mindfulness; Rumination; Psychological and physical well-being;
Depression
ID COGNITIVE-BEHAVIOR THERAPY; PERVASIVE DEVELOPMENTAL DISORDERS;
RANDOMIZED CONTROLLED-TRIAL; PSYCHIATRIC-DISORDERS; ASPERGER SYNDROME;
STRESS REDUCTION; MEDITATION; DEPRESSION; RUMINATION; ANXIETY
AB Individuals with autism spectrum disorders (ASD) have a higher incidence of comorbid disorders in comparison with other patient groups. Empirical evidence on treatments targeting comorbid symptoms is however scarce. Earlier research showed that mindfulness-based therapy for individuals on the autism spectrum (MBT-AS) is effective in reducing symptoms of depression, anxiety, and rumination. In the current study, it was examined whether MBT-AS is effective in alleviating a variety of psychosomatic symptoms and whether these effects were still evident after 9 weeks. Fifty participants took part in a nine-week MBT-AS training. Self-reported symptoms were evaluated at three intervals: (1) before the first session, (2) after the last session, and (3) 9 weeks after the last session. Results showed that symptoms of anxiety, depression, agoraphobia, somatization, inadequacy in thinking and acting, distrust and interpersonal sensitivity, sleeping problems, and general psychological and physical well-being declined significantly during intervention. Positive affect increased, and rumination declined significantly during treatment. Hostility symptoms did not decline significantly during treatment. All symptoms remained stable between post intervention and follow-up. This would seem to indicate that MBT-AS is effective in reducing psychological and physical symptoms and keeping them stable over the longer term. Furthermore, the outcome indicates that rumination is an important mediating factor. In conclusion, MBT-AS appears to be an effective method for reducing a variety of symptoms, and treatment gains remain stable over the longer term.
C1 [Kiep, Michelle; Spek, Annelies A.; Hoeben, Lisette] GGzE, Adult Autism Ctr, NL-5626 AB Eindhoven, Netherlands.
RP Kiep, M (reprint author), GGzE, Adult Autism Ctr, POB 1418, NL-5626 AB Eindhoven, Netherlands.
EM michellekiep@gmail.com
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NR 54
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1868-8527
EI 1868-8535
J9 MINDFULNESS
JI Mindfulness
PD JUN
PY 2015
VL 6
IS 3
BP 637
EP 644
DI 10.1007/s12671-014-0299-x
PG 8
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA CI0SP
UT WOS:000354448500022
ER
PT J
AU Clements, CC
Castro, VM
Blumenthal, SR
Rosenfield, HR
Murphy, SN
Fava, M
Erb, JL
Churchill, SE
Kaimal, AJ
Doyle, AE
Robinson, EB
Smoller, JW
Kohane, IS
Perlis, RH
AF Clements, C. C.
Castro, V. M.
Blumenthal, S. R.
Rosenfield, H. R.
Murphy, S. N.
Fava, M.
Erb, J. L.
Churchill, S. E.
Kaimal, A. J.
Doyle, A. E.
Robinson, E. B.
Smoller, J. W.
Kohane, I. S.
Perlis, R. H.
TI Prenatal antidepressant exposure is associated with risk for
attention-deficit hyperactivity disorder but not autism spectrum
disorder in a large health system
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID PREGNANCY; DEPRESSION
AB Previous studies suggested that risk for Autism Spectrum Disorder (ASD) may be increased in children exposed to antidepressants during the prenatal period. The disease specificity of this risk has not been addressed and the possibility of confounding has not been excluded. Children with ASD or attention-deficit hyperactivity disorder (ADHD) delivered in a large New England health-care system were identified from electronic health records (EHR), and each diagnostic group was matched 1:3 with children without ASD or ADHD. All children were linked with maternal health data using birth certificates and EHRs to determine prenatal medication exposures. Multiple logistic regression was used to examine association between prenatal antidepressant exposures and ASD or ADHD risk. A total of 1377 children diagnosed with ASD and 2243 with ADHD were matched with healthy controls. In models adjusted for sociodemographic features, antidepressant exposure prior to and during pregnancy was associated with ASD risk, but risk associated with exposure during pregnancy was no longer significant after controlling for maternal major depression (odds ratio (OR) 1.10 (0.70-1.70)). Conversely, antidepressant exposure during but not prior to pregnancy was associated with ADHD risk, even after adjustment for maternal depression (OR 1.81 (1.22-2.70)). These results suggest that the risk of autism observed with prenatal antidepressant exposure is likely confounded by severity of maternal illness, but further indicate that such exposure may still be associated with ADHD risk. This risk, modest in absolute terms, may still be a result of residual confounding and must be balanced against the substantial consequences of untreated maternal depression.
C1 [Clements, C. C.; Castro, V. M.; Blumenthal, S. R.; Rosenfield, H. R.; Doyle, A. E.; Robinson, E. B.; Perlis, R. H.] Massachusetts Gen Hosp, Dept Psychiat, Ctr Expt Drugs & Diagnost, Boston, MA 02114 USA.
[Clements, C. C.; Blumenthal, S. R.; Rosenfield, H. R.; Doyle, A. E.; Smoller, J. W.; Perlis, R. H.] Massachusetts Gen Hosp, Dept Psychiat, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
[Castro, V. M.; Murphy, S. N.] Partners HealthCare Syst, Partners Res Comp, Constitut Ctr 1, Boston, MA USA.
[Castro, V. M.; Murphy, S. N.] Massachusetts Gen Hosp, Comp Sci Lab, Boston, MA 02114 USA.
[Castro, V. M.; Murphy, S. N.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA.
[Fava, M.] Massachusetts Gen Hosp, Dept Psychiat, Depress Clin & Res Program, Boston, MA 02114 USA.
[Erb, J. L.] Brigham & Womens Hosp, Dept Psychiat, Boston, MA 02115 USA.
[Churchill, S. E.] Partners HealthCare Syst, Informat Syst, Boston, MA USA.
[Kaimal, A. J.] Massachusetts Gen Hosp, Dept Obstet & Gynecol, Div Maternal Fetal Med, Boston, MA 02114 USA.
[Robinson, E. B.] Massachusetts Gen Hosp, Ctr Human Genet Res, Analyt & Translat Genom Unit, Boston, MA 02114 USA.
[Kohane, I. S.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.
RP Perlis, RH (reprint author), Massachusetts Gen Hosp, Psychiat, Simches Res Bldg MGH,185 Cambridge St,6th Floor, Boston, MA 02114 USA.
EM rperlis@partners.org
FU National Institute of Mental Health [5R01MH100286-02]; NIMH
[R01MH086026]; Stanley Center for Psychiatric Research; NIH/National
Library of Medicine [2U54LM008748]
FX This work was supported through funding from the National Institute of
Mental Health (5R01MH100286-02). Dr Perlis is supported by NIMH
R01MH086026 and by the Stanley Center for Psychiatric Research. The i2b2
platform (PI: Kohane) is supported by award number 2U54LM008748 from the
NIH/National Library of Medicine. We express our gratitude to the staff
at the Massachusetts Registry of Vital Records and Statistics including
Kevin Foster and Dean DiMartino.
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NR 20
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUN
PY 2015
VL 20
IS 6
BP 727
EP 734
DI 10.1038/mp.2014.90
PG 8
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA CI6SB
UT WOS:000354890200011
PM 25155880
ER
PT J
AU Bale, TL
AF Bale, Tracy L.
TI Epigenetic and transgenerational reprogramming of brain development
SO NATURE REVIEWS NEUROSCIENCE
LA English
DT Review
ID HIGH-FAT DIET; EARLY-LIFE STRESS; MATERNAL IMMUNE ACTIVATION; AUTISM
SPECTRUM DISORDERS; PITUITARY-ADRENAL AXIS; 11-BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE-2; CORTICOTROPIN-RELEASING HORMONE;
GLUCOCORTICOID-RECEPTOR GENE; CENTRAL-NERVOUS-SYSTEM; PRENATAL STRESS
AB Neurodevelopmental programming - the implementation of the genetic and epigenetic blueprints that guide and coordinate normal brain development - requires tight regulation of transcriptional processes. During prenatal and postnatal time periods, epigenetic processes fine-tune neurodevelopment towards an end product that determines how an organism interacts with and responds to exposures and experiences throughout life. Epigenetic processes also have the ability to reprogramme the epigenome in response to environmental challenges, such as maternal stress, making the organism more or less adaptive depending on the future challenges presented. Epigenetic marks generated within germ cells as a result of environmental influences throughout life can also shape future generations long before conception occurs.
C1 [Bale, Tracy L.] Univ Penn, Sch Vet Med, Dept Biomed Sci, Philadelphia, PA 19104 USA.
[Bale, Tracy L.] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
RP Bale, TL (reprint author), Univ Penn, Sch Vet Med, Dept Biomed Sci, Philadelphia, PA 19104 USA.
EM tbale@vet.upenn.edu
FU US National Institutes of Health [MH099910, MH104184, MH091258,
MH087597, MH073030]
FX This work was supported by grants from the US National Institutes of
Health MH099910, MH104184, MH091258, MH087597 and MH073030.
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NR 180
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-003X
EI 1471-0048
J9 NAT REV NEUROSCI
JI Nat. Rev. Neurosci.
PD JUN
PY 2015
VL 16
IS 6
BP 332
EP 344
DI 10.1038/nrn3818
PG 13
WC Neurosciences
SC Neurosciences & Neurology
GA CI5PJ
UT WOS:000354810000007
PM 25921815
ER
PT J
AU Lenz, KM
McCarthy, MM
AF Lenz, Kathryn M.
McCarthy, Margaret M.
TI A Starring Role for Microglia in Brain Sex Differences
SO NEUROSCIENTIST
LA English
DT Review
DE microglia; development; sex differences; hormone; inflammation; immune;
cytokine; sex
ID AUTISM SPECTRUM DISORDERS; PRENATAL IMMUNE CHALLENGE; PREGNANCY HORMONE
ESTRIOL; ESTROGEN-RECEPTOR-ALPHA; CENTRAL-NERVOUS-SYSTEM; DEVELOPING
RAT-BRAIN; MAST-CELLS; CEREBRAL-CORTEX; X-CHROMOSOME; HIPPOCAMPAL
NEUROGENESIS
AB Microglia, the resident innate immune cells in the brain, have long been understood to be crucial to maintenance in the nervous system, by clearing debris, monitoring for infiltration of infectious agents, and mediating the brain's inflammatory and repair response to traumatic injury, stroke, or neurodegeneration. A wave of new research has shown that microglia are also active players in many basic processes in the healthy brain, including cell proliferation, synaptic connectivity, and physiology. Microglia, both in their capacity as phagocytic cells and via secretion of many neuroactive molecules, including cytokines and growth factors, play a central role in early brain development, including sexual differentiation of the brain. In this review, we present the vast roles microglia play in normal brain development and how perturbations in the normal neuroimmune environment during development may contribute to the etiology of brain-based disorders. There are notable differences between microglia and neuroimmune signaling in the male and female brain throughout the life span, and these differences may contribute to the vast differences in the incidence of neuropsychiatric and neurological disorders between males and females.
C1 [Lenz, Kathryn M.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
[Lenz, Kathryn M.] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA.
[McCarthy, Margaret M.] Univ Maryland, Sch Med, Dept Pharmacol & Program Neurosci, Baltimore, MD 21201 USA.
RP Lenz, KM (reprint author), Ohio State Univ, Dept Psychol, 1835 Neil Ave,Room 45, Columbus, OH 43210 USA.
EM lenz.56@osu.edu
FU National Insitute for Neurological Disorders and Stroke [F32NS076327];
National Institute for Mental Health [R01MH052716]; Ohio State
University startup funds
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This work
was supported by the National Insitute for Neurological Disorders and
Stroke (F32NS076327), the National Institute for Mental Health
(R01MH052716), and The Ohio State University startup funds.
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NR 142
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1073-8584
EI 1089-4098
J9 NEUROSCIENTIST
JI Neuroscientist
PD JUN
PY 2015
VL 21
IS 3
BP 306
EP 321
DI 10.1177/1073858414536468
PG 16
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CI5DR
UT WOS:000354773600011
PM 24871624
ER
PT J
AU Suarez, MA
AF Suarez, Michelle Ann
TI Multicomponent Treatment for Food Selectivity in Children: Description
and Case Report
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Article
DE pediatrics; feeding and eating disorders of childhood; feeding behavior;
food preferences; food selectivity
ID PEDIATRIC FEEDING DISORDERS; AUTISM SPECTRUM DISORDERS; INTERVENTION;
MOTHERS; MEAL
AB Background: Food selectivity is common in children with and without developmental disabilities and can have negative implications for nutrition intake and family quality of life. The evidence base for effective treatment protocols is still developing. Methods: The purpose of this study was to describe a pilot, multicomponent treatment protocol for food selectivity and present several case examples using a retrospective chart review. Elements in the treatment manual included sensory integration and behavioral modification strategies, including systematic desensitization. Also, parents were educated on factors associated with food selectivity and strategies for increasing food acceptance during family meals. Results: Four children with food selectivity demonstrated increased food acceptance of previously refused foods. Incidence of negative behaviors, including gagging, vomiting, and aggressive behavior (eg, hitting, batting away spoon), during clinical meals was also evaluated. No aggressive behavior or vomiting was observed during treatment sessions, and gagging on foods at initial introduction was minimal. Conclusions: This descriptive study and case review provides information to inform treatment of food selectivity and may provide a catalyst for larger scale clinical trials.
C1 [Suarez, Michelle Ann] Western Michigan Univ, Kalamazoo, MI 49008 USA.
RP Suarez, MA (reprint author), Western Michigan Univ, CHHS, 1903 W Michigan Ave, Kalamazoo, MI 49008 USA.
EM michelle.a.suarez@wmich.edu
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Smith AA, 2005, NUTRITION, V21, P14, DOI 10.1016/j.nut.2004.09.004
Suarez MA, 2014, AM J OCCUP THER, V68, P102, DOI 10.5014/ajot.2014.008748
Suarez MA, 2012, OPEN J OCCUP THER, V1
Suarez MA, 2013, LONGITUDINAL FOLLOW
Toomey K, 2007, PEDIAT FEEDING DYSPH, V8, P2
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NR 34
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD JUN
PY 2015
VL 30
IS 3
BP 425
EP 431
DI 10.1177/0884533614553638
PG 7
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA CI5DN
UT WOS:000354773200016
PM 25378354
ER
PT J
AU Shen, TJ
Ji, F
Yuan, ZQ
Jiao, JW
AF Shen, Tianjin
Ji, Fen
Yuan, Zengqiang
Jiao, Jianwei
TI CHD2 is Required for Embryonic Neurogenesis in the Developing Cerebral
Cortex
SO STEM CELLS
LA English
DT Article
DE Embryonic stem cells; Progenitor cells; Neural differentiation;
Proliferation; Self-renewal; Neural stem cell
ID AUTISM SPECTRUM DISORDERS; DE-NOVO MUTATIONS; PROGENITOR CELLS;
GENE-EXPRESSION; SELF-RENEWAL; STEM-CELLS; REST; DIFFERENTIATION;
PLURIPOTENCY; REPRESSOR
AB Chromodomain helicase DNA-binding protein 2 (CHD2) has been associated with a broad spectrum of neurodevelopmental disorders, such as autism spectrum disorders and intellectual disability. However, it is largely unknown whether and how CHD2 is involved in brain development. Here, we demonstrate that CHD2 is predominantly expressed in Pax6(+) radial glial cells (RGs) but rarely expressed in Tbr2(+) intermediate progenitors (IPs). Importantly, the suppression of CHD2 expression inhibits the self-renewal of RGs and increases the generation of IPs and the production of neurons. CHD2 mediates these functions by directly binding to the genomic region of repressor element 1-silencing transcription factor (REST), thereby regulating the expression of REST. Furthermore, the overexpression of REST rescues the defect in neurogenesis caused by CHD2 knockdown. Taken together, these findings demonstrate an essential role of CHD2 in the maintenance of the RGs self-renewal levels, the subsequent generation of IPs, and neuronal output during neurogenesis in cerebral cortical development, suggesting that inactivation of CHD2 during neurogenesis might contribute to abnormal neurodevelopment. Stem Cells2015;33:1794-1806
C1 [Shen, Tianjin; Ji, Fen; Jiao, Jianwei] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China.
[Yuan, Zengqiang] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China.
[Shen, Tianjin] Univ Chinese Acad Sci, Beijing, Peoples R China.
RP Jiao, JW (reprint author), Chinese Acad Sci, Inst Zool, Grp Neural Stem Cell & Neurogenesis, 1 Beichen West Rd, Beijing 100101, Peoples R China.
EM jwjiao@ioz.ac.cn
RI Jiao, Jianwei/I-1452-2013
OI Jiao, Jianwei/0000-0002-7893-0721
FU National Key Basic Research Program of China [2015CB964500,
2014CB964903, 2014CB964602]; National Science Foundation of China
[31371477, 31300894]; Strategic Priority Research Program [XDA01020301]
FX This work was supported by grants obtained from the National Key Basic
Research Program of China (2015CB964500, 2014CB964903, and
2014CB964602), the National Science Foundation of China (31371477 and
31300894), and the Strategic Priority Research Program (XDA01020301).
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NR 36
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1066-5099
EI 1549-4918
J9 STEM CELLS
JI Stem Cells
PD JUN
PY 2015
VL 33
IS 6
BP 1794
EP 1806
DI 10.1002/stem.2001
PG 13
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology;
Oncology; Cell Biology; Hematology
SC Cell Biology; Biotechnology & Applied Microbiology; Oncology; Hematology
GA CI6PJ
UT WOS:000354882500010
PM 25786798
ER
PT J
AU Liu, J
Yang, AP
Zhang, QW
Yang, GH
Yang, WJ
Lei, HY
Quan, JJ
Qu, F
Wang, M
Zhang, ZY
Yu, K
AF Liu, Jun
Yang, Aiping
Zhang, Qunwei
Yang, Guohui
Yang, Wenjun
Lei, Heyue
Quan, Jianjun
Qu, Fei
Wang, Min
Zhang, Zengyu
Yu, Ke
TI Association between genetic variants in SLC25A12 and risk of autism
spectrum disorders: An integrated meta-analysis
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE ASD; SLC25A12 gene; polymorphism; susceptibility; meta-analysis
ID SYSTEMATIC REVIEWS; GLUTAMATE CARRIER; MITOCHONDRIAL; SUSCEPTIBILITY;
HETEROGENEITY; PREVALENCE; LINKAGE; MARKERS; SCREEN; ARALAR
AB The solute carrier family 25 (aspartate/glutamate carrier), member 12 gene (SLC25A12) has been strongly posed as a candidate gene for autism spectrum disorder (ASD) given its important role in mitochondrial function and adenosine triphosphate (ATP) synthesis. Evidence is mounting for the association between SLC25A12 variants (rs2056202 and rs2292813) and ASD risk, but the results are inconsistent. To clarify the effect of these two variants on ASD, a meta-analysis integrating case-control and transmission disequilibrium test (TDT) studies was performed. The PubMed, Embase, Cochrane Library, Web of Science, Chinese BioMedical Literature (CBM), Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant studies published up to May 2014. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated to assess the strength of association. A total of 775 cases, 922 controls, and 1289 families available from 8 studies concerning rs2056202, and 465 cases, 450 controls, and 1516 families available from 7 studies concerning rs2292813 were finally included. In the overall meta-analysis, the rs2056202 T allele and rs2292813 T allele were both significantly associated with a decreased risk of ASD (rs2056202: OR=0.809, P=0.001, 95%CI: 0.713-0.917, I-2=0.0%, and P-heterogeneity=0.526; rs2292813: OR=0.752, P<0.001, 95%CI: 0.649-0.871, I-2=0.0%, P-heterogeneity=0.486). Besides, subjects with T-T haplotype of rs2056202-rs2292813 had a significantly reduced risk of ASD (OR=0.672, P<0.001, 95%CI: 0.564-0.801, I-2=0.0%, P-heterogeneity=0.631). Sensitivity analysis, cumulative meta-analysis, and publication bias diagnostics confirmed the reliability and stability of our results. Our meta-analysis suggests that rs2056202 and rs2292813 in SLC25A12 may contribute significantly to ASD risk. (c) 2015 Wiley Periodicals, Inc.
C1 [Liu, Jun; Yang, Aiping; Zhang, Qunwei; Yang, Guohui; Yang, Wenjun; Lei, Heyue; Quan, Jianjun; Qu, Fei; Wang, Min] Zhejiang Xiaoshan Hosp, Dept Clin Lab, Hangzhou 311202, Zhejiang, Peoples R China.
[Zhang, Zengyu] Hangzhou Normal Univ, Dept Paediat, Xiaoshan Hosp 1, Hangzhou, Zhejiang, Peoples R China.
[Yu, Ke] Zhejiang Univ, Zhejiang California Int Nanosyst Inst, Hangzhou 310029, Zhejiang, Peoples R China.
RP Liu, J (reprint author), Zhejiang Xiaoshan Hosp, Dept Clin Lab, Hangzhou 311202, Zhejiang, Peoples R China.
EM xiaoshanry@163.com; yuke2009@gmail.com
FU Xiaoshan Science and Technology Commission of Hangzhou City [2013303];
Health and Family Planning Commission of Zhejiang Province [2014kyB225]
FX Grant sponsor: Xiaoshan Science and Technology Commission of Hangzhou
City; Grant number: 2013303; Grant sponsor: Health and Family Planning
Commission of Zhejiang Province; Grant number: 2014kyB225.
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NR 40
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUN
PY 2015
VL 168
IS 4
BP 236
EP 246
DI 10.1002/ajmg.b.32304
PG 11
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA CI3IA
UT WOS:000354640100002
PM 25921325
ER
PT J
AU Liu, Y
Zhang, YQ
Zhao, DM
Dong, R
Yang, XM
Tammimies, K
Uddin, M
Scherer, SW
Gai, ZT
AF Liu, Yi
Zhang, Yanqing
Zhao, Dongmei
Dong, Rui
Yang, Xiaomeng
Tammimies, Kristiina
Uddin, Mohammed
Scherer, Stephen W.
Gai, Zhongtao
TI Rare de novo deletion of metabotropic glutamate receptor 7 (GRM7) gene
in a patient with autism spectrum disorder
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE metabotropic glutamate receptor 7 gene (GRM7); autism spectrum disorders
(ASDs); neuropsychiatric disorders
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; COPY NUMBER VARIATION;
RS3792452 POLYMORPHISM; AMYGDALA PLASTICITY; BIPOLAR DISORDER; VARIANTS;
ASSOCIATION; SCHIZOPHRENIA; CHILDREN; BEHAVIOR
AB GRM7, the gene encoding metabotropic glutamate receptor 7 (mGluR7), have been implicated in multiple neuropsychiatric disorders and shown to mediate excitatory synaptic neurotransmitter signaling and plasticity in the mammalian brain. Here we report a 303kb de novo deletion at band 3p26.1, disrupting five coding exons of GRM7 in a proband with autism spectrum disorder, and hyperactivity. Our exon transcriptome-mutation contingency index method shows that three of the exons within the breakpoint boundaries are under purifying selection and highly expressed in prenatal brain regions. Based on our results and a thorough review of the literature, we propose that haploinsufficiency of the GRM7 product (mGluR7) contributes to autism spectrum disorders and hyperactivity phenotype as seen in the patient described here. (c) 2015 Wiley Periodicals, Inc.
C1 [Liu, Yi; Dong, Rui; Yang, Xiaomeng; Gai, Zhongtao] Shandong Univ, Pediat Res Inst, Qilu Childrens Hosp, Jinan 250022, Peoples R China.
[Zhang, Yanqing; Zhao, Dongmei; Gai, Zhongtao] Shandong Univ, Pediat Hlth Care Inst, Qilu Childrens Hosp, Jinan 250022, Peoples R China.
[Tammimies, Kristiina; Uddin, Mohammed; Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1L7, Canada.
[Tammimies, Kristiina] Karolinska Inst, Ctr Neurodev Disorders, Karolinska Inst KIND, Pediat Neuropsychiat Unit,Dept Womens & Childrens, Stockholm, Sweden.
[Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON M5S 1A1, Canada.
[Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada.
RP Scherer, SW (reprint author), Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1L7, Canada.
EM stephen.scherer@sickkids.ca; gaizhongtaoi@sina.com
FU GSK-CIHR
FX The authors are grateful to the patients and their families for their
contribution to the project. We would like to thank Shanghai
Biotechnology Co, Shanghai Biochip National Engineering Research Center
for technical support, as well as The Centre for Applied Genomics at the
Hospital for Sick Children and the University of Toronto McLaughlin
Centre. S.W.S. is supported by the GSK-CIHR Endowed Chair in Genome
Sciences.
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NR 41
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD JUN
PY 2015
VL 168
IS 4
BP 258
EP 264
DI 10.1002/ajmg.b.32306
PG 7
WC Genetics & Heredity; Psychiatry
SC Genetics & Heredity; Psychiatry
GA CI3IA
UT WOS:000354640100004
PM 25921429
ER
PT J
AU Sokhadze, T
El-Baz, AS
Tasman, A
Sears, L
Wang, Y
Casanova, MF
AF Sokhadze, Tato
El-Baz, Ayman S.
Tasman, Allan
Sears, Lonnie
Wang, Yao
Casanova, Manuel F.
TI Combined Neuromodulation Therapy Integrating rTMS and EEG Biofeedback
for Treatment of Children with Autism Spectrum Disorder
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Meeting Abstract
DE Transcranial magnetic stimulation; Autism spectrum disorder; Prefrontal
EEG biofeedback; Dorso-lateral prefrontal cortex
EM tato.sokhadze@louisville.edu
NR 0
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
EI 1573-3270
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD JUN
PY 2015
VL 40
IS 2
BP 120
EP 120
PG 1
WC Psychology, Clinical
SC Psychology
GA CI1JA
UT WOS:000354498700012
ER
PT J
AU Wang, Y
Hensley, MK
Casanova, MF
Sokhadze, E
AF Wang, Yao
Hensley, Marie K.
Casanova, Manuel F.
Sokhadze, Estate (Tato)
TI Prefrontal rTMS Treatment Effects on Autonomic Activity in Children with
Autism
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Meeting Abstract
DE Autism spectrum disorder; Transcranial magnetic stimulation; Children;
Autonomic activity; Heart rate variability
EM wangyao8488@gmail.com
NR 0
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
EI 1573-3270
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD JUN
PY 2015
VL 40
IS 2
BP 122
EP 122
PG 1
WC Psychology, Clinical
SC Psychology
GA CI1JA
UT WOS:000354498700016
ER
PT J
AU Frederick, J
Wang, Y
Sokhadze, T
Sears, L
Tasman, A
Casanova, MF
AF Frederick, Jon
Wang, Yao
Sokhadze, Tato
Sears, Lonnie
Tasman, Allan
Casanova, Manuel F.
TI ERP and EEG Oscillations Study of Facial Expression Processing Deficits
in Autism
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Meeting Abstract
DE Event related potentials; Single trial induced EEG; Autism spectrum
disorder; Emotional recognition
EM psyphy2014@gmail.com
NR 0
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
EI 1573-3270
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD JUN
PY 2015
VL 40
IS 2
BP 129
EP 130
PG 2
WC Psychology, Clinical
SC Psychology
GA CI1JA
UT WOS:000354498700031
ER
PT J
AU Hamilton, S
AF Hamilton, Sheila
TI Functional behavior assessment for people with autism: Making sense of
senseless behavior
SO CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE
LA English
DT Book Review
CR GLASBERG BA, 2015, FUNCTIONAL BEHAV ASS
NR 1
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0008-4174
EI 1911-9828
J9 CAN J OCCUP THER
JI Can. J. Occup. Ther.
PD JUN
PY 2015
VL 82
IS 3
BP 204
EP 204
DI 10.1177/0008417415583109
PG 1
WC Rehabilitation
SC Rehabilitation
GA CI2IW
UT WOS:000354570900011
ER
PT J
AU De Rubeis, S
Buxbaum, JD
AF De Rubeis, Silvia
Buxbaum, Joseph D.
TI Recent Advances in the Genetics of Autism Spectrum Disorder
SO CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
LA English
DT Review
DE Autism spectrum disorder; Autism risk genes; Exome sequencing; Copy
number variation; De novo variation; Heritability
ID DE-NOVO MUTATIONS; COPY-NUMBER VARIATION; NEURODEVELOPMENTAL DISORDERS;
INTELLECTUAL DISABILITY; SYNAPTIC DEFECTS; PATERNAL ORIGIN; HUMAN BRAIN;
RISK; VARIANTS; GENES
AB Autism spectrum disorder (ASD) is a devastating neurodevelopmental disorder with high prevalence in the population and a pronounced male preponderance. ASD has a strong genetic basis, but until recently, a large fraction of the genetic factors contributing to liability was still unknown. Over the past 3 years, high-throughput next-generation sequencing on large cohorts has exposed a heterogeneous and complex genetic landscape and has revealed novel risk genes. Here, we provide an overview of the recent advances on the ASD genetic architecture, with an emphasis on the estimates of heritability, the contribution of common variants, and the role of inherited and de novo rare variation. We also examine the genetic components of the reported gender bias. Finally, we discuss the emerging findings from sequencing studies and how they illuminate crucial aspects of ASD pathophysiology.
C1 [De Rubeis, Silvia; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
[De Rubeis, Silvia; Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
RP De Rubeis, S (reprint author), Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
EM joseph.buxbaum@mssm.edu
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NR 83
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1528-4042
EI 1534-6293
J9 CURR NEUROL NEUROSCI
JI Curr. Neurol. Neurosci. Rep.
PD JUN
PY 2015
VL 15
IS 6
AR 36
DI 10.1007/s11910-015-0553-1
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CI0WD
UT WOS:000354459100008
PM 25946996
ER
PT J
AU Turner, SJ
Morgan, AT
Perez, ER
Scheffer, IE
AF Turner, Samantha J.
Morgan, Angela T.
Perez, Eliane Roulet
Scheffer, Ingrid E.
TI New Genes for Focal Epilepsies with Speech and Language Disorders
SO CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
LA English
DT Review
DE Epilepsy-aphasia spectrum; Speech; Language; Gene; Landau-Kleffner
syndrome; Epileptic encephalopathy with continuous spike-wave during
sleep; Benign childhood epilepsy with centro-temporal spikes; GRIN2A;
RBFOX genes; Copy number variants; Dysarthria; Speech dyspraxia;
Oromotor dyspraxia; Continuous spike-wave in slow sleep; Rolandic;
Atypical benign partial epilepsy; Autosomal dominant rolandic epilepsy
with speech dyspraxia
ID LANDAU-KLEFFNER-SYNDROME; BENIGN CHILDHOOD EPILEPSY; NMDA RECEPTOR
SUBUNITS; ELECTRICAL STATUS EPILEPTICUS; IDIOPATHIC ROLANDIC EPILEPSY;
CENTRO-TEMPORAL SPIKES; CENTROTEMPORAL SPIKES; MICRODELETION SYNDROME;
ACQUIRED APHASIA; INHERITED SPEECH
AB The last 2 years have seen exciting advances in the genetics of Landau-Kleffner syndrome and related disorders, encompassed within the epilepsy-aphasia spectrum (EAS). The striking finding of mutations in the N-methyl-D-aspartate (NMDA) receptor subunit gene GRIN2A as the first monogenic cause in up to 20 % of patients with EAS suggests that excitatory glutamate receptors play a key role in these disorders. Patients with GRIN2A mutations have a recognizable speech and language phenotype that may assist with diagnosis. Other molecules involved in RNA binding and cell adhesion have been implicated in EAS; copy number variations are also found. The emerging picture highlights the overlap between the genetic determinants of EAS with speech and language disorders, intellectual disability, autism spectrum disorders and more complex developmental phenotypes.
C1 [Turner, Samantha J.; Morgan, Angela T.; Scheffer, Ingrid E.] Univ Melbourne, Dept Paediat, Royal Childrens Hosp, Parkville, Vic 3052, Australia.
[Turner, Samantha J.; Morgan, Angela T.] Murdoch Childrens Res Inst, Language & Literacy Grp, Parkville, Vic, Australia.
[Morgan, Angela T.] Royal Childrens Hosp, Speech Pathol Dept, Parkville, Vic 3052, Australia.
[Perez, Eliane Roulet] Hosp Univ Vaudois, Paediat Neurol & Neurorehabil Unit, Lausanne, Switzerland.
[Scheffer, Ingrid E.] Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia.
[Turner, Samantha J.; Scheffer, Ingrid E.] Univ Melbourne, Dept Med, Epilepsy Res Ctr, Austin Hlth, Melbourne, Vic, Australia.
RP Scheffer, IE (reprint author), Univ Melbourne, Dept Paediat, Royal Childrens Hosp, Parkville, Vic 3052, Australia.
EM s.turner4@student.unimelb.edu.au; angela.morgan@mcri.edu.au;
Eliane.Roulet-Perez@chuv.ch; scheffer@unimelb.edu.au
FU National Health and Medical Research Council; Speech Pathology
Australia; Australian Research Council; NHMRC; NIH; ARC
FX Samantha J. Turner has received grants from the National Health and
Medical Research Council (postgraduate scholarship) and the Speech
Pathology Australia (Nadia Verrall Memorial Research Grant).Angela T.
Morgan has received grants from the National Health and Medical Research
Council (Career Development Award) and the Australian Research Council
(Discovery Project).Ingrid E. Scheffer has received grants from the
NHMRC (CI, Program Grant 2011-2015), the NIH (PI, Centres without Walls
funding "Epi4K" 2011-2015) and the ARC (Discovery Grant 2012-2014).
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NR 115
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1528-4042
EI 1534-6293
J9 CURR NEUROL NEUROSCI
JI Curr. Neurol. Neurosci. Rep.
PD JUN
PY 2015
VL 15
IS 6
AR 35
DI 10.1007/s11910-015-0554-0
PG 13
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CI0WD
UT WOS:000354459100007
PM 25921602
ER
PT J
AU Ben-Sasson, A
Amit-Ben-Simhon, H
Meyer, S
AF Ben-Sasson, Ayelet
Amit-Ben-Simhon, Hemda
Meyer, Sonya
TI Cross-parent reliability in rating ASD markers in infants
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE ASD; autism; cross-parent; infant; reliability; screening
ID CHILD-BEHAVIOR CHECKLIST; SPECTRUM DISORDER; AUTISTIC TRAITS;
DISCREPANCIES; AGREEMENT; TODDLERS
AB Objective: To investigate the congruence and discrepancies between mother and father reports of early autism spectrum disorders (ASD) markers.
Methods: Mothers (n = 80) and fathers (n = 78) of 12-month-old infants (55% boys) completed the first year inventory (FYI), an ASD norm-referenced screening questionnaire. Mothers also completed the Infant Toddler Social Emotional Assessment (ITSEA).
Results: There were significant and moderate intra-class correlations between mother and father reports for most FYI factors. Fathers' median FYI social-communication domain score was almost twice that of mothers. Mann-Whitney tests indicated that fathers rated their child significantly higher than mothers on the four FYI social-communication factors and on the sensory processing factor. Linear weighted kappa analyses indicated poor agreement on gaze-related and reactivity FYI items. FYI social-communication and sensory-regulatory factors showed significant correlations with corresponding ITSEA scores.
Conclusions: Social-communication markers pose a greater challenge for consistent report across parents than sensory-regulatory markers.
C1 [Ben-Sasson, Ayelet; Amit-Ben-Simhon, Hemda; Meyer, Sonya] Univ Haifa, Fac Social Welf & Hlth Sci, Dept Occupat Therapy, IL-30905 Haifa, Israel.
[Amit-Ben-Simhon, Hemda] Child Dev Ctr Maccabi Haifa, Haifa, Israel.
[Meyer, Sonya] Child Dev Ctr Maccabi Hod Hasharon, Tel Aviv, Israel.
RP Ben-Sasson, A (reprint author), Univ Haifa, Fac Social Welf & Hlth Sci, Dept Occupat Therapy, IL-30905 Haifa, Israel.
EM asasson@univ.haifa.ac.il
FU European international reintegration grant [203715]
FX This study has been supported by a European international reintegration
grant (# 203715).
CR Achenbach TM, 2006, CURR DIR PSYCHOL SCI, V15, P94, DOI 10.1111/j.0963-7214.2006.00414.x
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Lamb M., 2010, ROLE FATHER CHILD DE, P94
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van Zeijl J, 2006, J CHILD PSYCHOL PSYC, V47, P801, DOI 10.1111/j.1469-7610.2006.01616.x
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NR 32
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
EI 1751-8431
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD JUN
PY 2015
VL 18
IS 3
BP 155
EP 161
DI 10.3109/17518423.2013.800164
PG 7
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA CH7KZ
UT WOS:000354216600003
PM 23924084
ER
PT J
AU Castro, S
Pinto, A
AF Castro, Susana
Pinto, Ana
TI Matrix for assessment of activities and participation: Measuring
functioning beyond diagnosis in young children with disabilities
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE Engagement; environment; functioning patterns; ICF-CY; measure
ID INTERNATIONAL CLASSIFICATION; HEALTH; ISSUES
AB Objective: (i) To study the functioning patterns of young children with disabilities compared with typically developing children, using a new ICF-CY based tool - the Matrix for Assessment of Activities and Participation; (ii) study the factors that predict these functioning patterns.
Methods: The MAAP tool was administered to three groups of children: (i) with autism, (ii) with other types of disabilities and (iii) typically developing.
Results: Cluster analysis showed that children group according to the severity of their functioning profile and not according to the diagnostic category in which they were classified. Multiple regression analysis showed that a model comprising the environmental factors and the level of engagement in different routines of the child is a good predictor of these children's functioning patterns.
Conclusion: These results support a functional approach to disability instead of the traditional medical model approach, underlining the role of engagement and environment in determining functioning.
C1 [Castro, Susana; Pinto, Ana] Univ Porto, Fac Psychol & Educ Sci, P-4200135 Oporto, Portugal.
RP Castro, S (reprint author), Univ Porto, Fac Psychol & Educ Sci, Rua Alfredo Allen, P-4200135 Oporto, Portugal.
EM susanacastro161@gmail.com
FU Fundacao para a a Ciencia e Tecnologia (FCT)
FX The authors report no conflicts of interest. The authors alone are
responsible for the content and writing of this paper. The authors wish
to thank Fundacao para a a Ciencia e Tecnologia (FCT) for funding this
study.
CR Almqvist L, 2007, S AFR J OCCUP THER, V37, P8
American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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Bagnato SJ, 2008, AUTHENTIC ASSESSMENT
Bagnato SJ, 2010, LINKING AUTHENTIC AS
Bergman LR, 2003, STUDYING INDIVIDUAL
Castro S, 2013, DISABIL REHABIL, V35, P125, DOI 10.3109/09638288.2012.690494
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Field A., 2009, DISCOVERING STAT USI
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World Health Organisation, 2001, INT CLASS FUNCT DIS
World Health Organization, 2010, INT CLASS DIS HLTH R
World Health Organization (WHO), 2007, INT CLASS FUNCT DIS
NR 32
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
EI 1751-8431
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD JUN
PY 2015
VL 18
IS 3
BP 177
EP 189
DI 10.3109/17518423.2013.806963
PG 13
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA CH7KZ
UT WOS:000354216600006
PM 23869963
ER
PT J
AU Adolfsson, M
Fleischer, AS
AF Adolfsson, Margareta
Fleischer, Ann Simmeborn
TI Applying the ICF to identify requirements for students with Asperger
syndrome in higher education
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE Asperger syndrome; higher education; ICF; requirement; student; support
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM; INTERNATIONAL
CLASSIFICATION; CORE SETS; DISABILITY; HEALTH; CHILDREN; YOUTH; CY;
INTERVENTION
AB Higher education requires more than academic skills and everyday student-life can be stressful. Students with Asperger syndrome (AS) may need support to manage their education due to difficulties in social functioning.
Objective: As preparation for the development of a structured tool to guide student and coordinator dialogues at Swedish universities, this study aimed to identify ICF categories that reflect requirements in everyday student-life for students with AS.
Methods: Using descriptive qualitative approach, information in documents reflecting the perspectives of university students, international classifications, user/health organisations and education authorities were linked to ICF codes.
Results: In total, 114 ICF categories were identified, most of which related to learning, tasks and demands, communication and interactions.
Conclusion: Students with AS need varying accommodations to be successful in higher education. In the future, ICF-based code sets, including demands on student roles, can be used as checklists to describe functioning and needs for support.
C1 [Adolfsson, Margareta; Fleischer, Ann Simmeborn] Jonkoping Univ, Sch Educ & Commun, CHILD, SE-55111 Jonkoping, Sweden.
[Adolfsson, Margareta; Fleischer, Ann Simmeborn] Jonkoping Univ, Sch Hlth Sci, Swedish Inst Disabil Res, SE-55111 Jonkoping, Sweden.
RP Adolfsson, M (reprint author), Jonkoping Univ, Sch Educ & Commun, POB 1026, SE-55111 Jonkoping, Sweden.
EM margareta.adolfs-son@hlk.hj.se
FU Sunnerdahl's Disability Foundation [dnr 38/12]
FX The research was supported by Sunnerdahl's Disability Foundation (dnr
38/12).
CR Adolfsson M, 2013, BRIT J OCCUP THER, V76, P127, DOI 10.4276/030802213X13627524435144
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Castro S, 2013, DISABIL REHABIL, V35, P125, DOI 10.3109/09638288.2012.690494
Cieza A, 2005, J REHABIL MED, V37, P212, DOI 10.1080/16501970510040263
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World Health Organisation, 2001, INT CLASS FUNCT DIS
World Health Organization, 1990, INT CLASS DIS VERS 1
World Health Organization (WHO), 2007, INT CLASS FUNCT DIS
NR 56
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
EI 1751-8431
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD JUN
PY 2015
VL 18
IS 3
BP 190
EP 202
DI 10.3109/17518423.2013.819947
PG 13
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA CH7KZ
UT WOS:000354216600007
PM 23957214
ER
PT J
AU Gerow, S
Rispoli, M
Boles, MB
Neely, LC
AF Gerow, Stephanie
Rispoli, Mandy
Boles, Margot B.
Neely, Leslie C.
TI An analysis of contingency statements in a DRO procedure: A case report
SO DEVELOPMENTAL NEUROREHABILITATION
LA English
DT Article
DE Autism; challenging behaviour; contingency statements; DRO; repetitive
speech
ID DIFFERENTIAL REINFORCEMENT; VOCAL STEREOTYPY; DISRUPTIVE BEHAVIOR;
SELF-MANAGEMENT; AUTISM; CHILDREN; SCHEDULES; INSTRUCTION; CLASSROOM
AB Objective: To examine latency to criterion for reduction of challenging behaviour with and without stating a contingency statement immediately prior to a DRO procedure.
Method: An ABAC design in which A was baseline, B was used to evaluate the efficacy of a DRO procedure, and C was used to evaluate the efficacy of a DRO procedure with a contingency statement.
Results: The DRO with the contingency statement intervention was associated with a shorter latency to behaviour change than the DRO procedure without the contingency statement.
Discussion: These preliminary findings from this case study highlight the importance of examining the efficiency of behaviour change procedures. Directions for future research are provided.
C1 [Gerow, Stephanie; Rispoli, Mandy; Boles, Margot B.; Neely, Leslie C.] Texas A&M Univ, Educ Psychol, College Stn, TX 77843 USA.
RP Gerow, S (reprint author), Texas A&M Univ, Educ Psychol, College Stn, TX 77843 USA.
EM stgerow@neo.tamu.edu
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NR 37
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1751-8423
EI 1751-8431
J9 DEV NEUROREHABIL
JI Dev. Neurorehabil.
PD JUN
PY 2015
VL 18
IS 3
BP 203
EP 208
DI 10.3109/17518423.2013.809812
PG 6
WC Clinical Neurology; Pediatrics; Rehabilitation
SC Neurosciences & Neurology; Pediatrics; Rehabilitation
GA CH7KZ
UT WOS:000354216600008
PM 23870002
ER
PT J
AU Katoh, M
AF Katoh, Masaru
TI Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and
ASXL3: a convergence of proteomics and epigenetics for translational
medicine
SO EXPERT REVIEW OF PROTEOMICS
LA English
DT Review
DE acute myeloid leukemia; cardiovascular development; colorectal cancer;
Forkhead-box transcription factor; hepatocellular carcinoma; melanoma;
microsatellite instability; myelodysplastic syndrome; ovarian cancer;
pancreatic cancer
ID ADDITIONAL-SEX-COMBS; NUCLEAR RECEPTOR SUPERFAMILY; PROTEIN-PROTEIN
INTERACTIONS; ACUTE MYELOID-LEUKEMIA; BOHRING-OPITZ SYNDROME; GENE
IN-SILICO; PHD FINGER; MYELODYSPLASTIC SYNDROMES; MASS-SPECTROMETRY;
BREAST-CANCER
AB ASXL1, ASXL2 and ASXL3 are epigenetic scaffolds for BAP1, EZH2, NCOA1, nuclear receptors and WTIP. Here, functional proteomics of the ASXL family members are reviewed with emphasis on mutation spectra, the ASXM2 domain and the plant homeodomain (PHD) finger. Copy number gains of ASXL1 occur in chromosome 20q11.2 duplication syndrome and cervical cancer. Truncation mutations of ASXLs occur in autism, Bohring-Opitz and related syndromes, hematological malignancies and solid tumors, such as prostate cancer, breast cancer and high-grade glioma, which are gain-or loss-of-function mutations. The ASXM2 domain is a binding module for androgen receptor and estrogen receptor a, while the PHD finger is a ligand of WTIP LIM domains and a putative chromatin-binding module. Phylogenetic analyses of 139 human PHD fingers revealed that ASXL PHD fingers cluster with those of BPTF, DIDO, ING1, KDM5A (JARID1A), KMT2E (MLL5), PHF2, PHF8 and PHF23. The cell context-dependent epigenetic code of ASXLs should be deciphered to develop therapeutics for human diseases.
C1 Natl Canc Ctr Japan, Dept Om Network, Tokyo 1040045, Japan.
RP Katoh, M (reprint author), Natl Canc Ctr Japan, Dept Om Network, 5-1-1 Tsukiji Chuo Ward, Tokyo 1040045, Japan.
EM mkatoh-kkr@umin.ac.jp
FU Masaru Katoh's Fund
FX This study was supported in part by a grant-in-aid for the Knowledgebase
Project from the Masaru Katoh's Fund. The author has no other relevant
affiliations or financial involvement with any organization or entity
with a financial interest in or financial conflict with the subject
matter or materials discussed in the manuscript apart from those
disclosed.
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NR 126
TC 0
Z9 0
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1478-9450
EI 1744-8387
J9 EXPERT REV PROTEOMIC
JI Expert Rev. Proteomics
PD JUN
PY 2015
VL 12
IS 3
BP 317
EP 328
DI 10.1586/14789450.2015.1033409
PG 12
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA CI2WZ
UT WOS:000354610000009
PM 25835095
ER
PT J
AU Ochs, E
AF Ochs, Elinor
TI Corporeal Reflexivity and Autism
SO INTEGRATIVE PSYCHOLOGICAL AND BEHAVIORAL SCIENCE
LA English
DT Article
DE Autism; Body; Stigma; Reflexivity; Perspective-taking
ID MIND
AB Ethnographic video recordings of high functioning children with autism or Aspergers Syndrome in everyday social encounters evidence their first person perspectives. High quality visual and audio data allow detailed analysis of children's bodies and talk as loci of reflexivity. Corporeal reflexivity involves displays of awareness of one's body as an experiencing subject and a physical object accessible to the gaze of others. Gaze, demeanor, actions, and sotto voce commentaries on unfolding situations indicate a range of moment-by-moment reflexive responses to social situations. Autism is associated with neurologically based motor problems (e.g. delayed action-goal coordination, clumsiness) and highly repetitive movements to self-soothe. These behaviors can provoke derision among classmates at school. Focusing on a 9-year-old girl's encounters with peers on the playground, this study documents precisely how autistic children can become enmeshed as unwitting objects of stigma and how they reflect upon their social rejection as it transpires. Children with autism spectrum disorders in laboratory settings manifest diminished understandings of social emotions such as embarrassment, as part of a more general impairment in social perspective-taking. Video ethnography, however, takes us further, into discovering autistic children's subjective sense of vulnerability to the gaze of classmates.
C1 Univ Calif Los Angeles, Dept Anthropol, Los Angeles, CA 90095 USA.
RP Ochs, E (reprint author), Univ Calif Los Angeles, Dept Anthropol, 341 Haines Hall, Los Angeles, CA 90095 USA.
EM eochs@anthro.ucla.edu
FU Spencer Foundation for Educational and Related Research; project
'Autistic Children's Narrative Interactions at School and Home'
FX This analysis has benefitted from years of dialogue and collaboration
with Olga Solomon, whose continuing research on the lived worlds of
children with autism spectrum disorders is source of inspiration. I am
also grateful to Rachel Flamenbaum for her assistance in presenting the
video and audio data for this study. This research is part of a larger
study 'Socializing Autistic Children into the Rules of School and Family
Life,' funded by the Spencer Foundation for Educational and Related
Research (E. Ochs, Principal Investigator 2000-2003). The data were
collected during a Spencer-funded project 'Autistic Children's Narrative
Interactions at School and Home,' (E. Ochs and L. Capps, Co-Principal
Investigators, 1997-2000).
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NR 37
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1932-4502
EI 1936-3567
J9 INTEGR PSYCHOL BEHAV
JI Integr. Psychol. Behav. Sci.
PD JUN
PY 2015
VL 49
IS 2
BP 275
EP 287
DI 10.1007/s12124-015-9306-6
PG 13
WC Psychology, Biological; Neurosciences
SC Psychology; Neurosciences & Neurology
GA CI0BF
UT WOS:000354399900012
PM 25939529
ER
PT J
AU Kryzak, LA
Jones, EA
AF Kryzak, Lauren A.
Jones, Emily A.
TI The Effect of Prompts within Embedded Circumscribed Interests to Teach
Initiating Joint Attention in Children with Autism Spectrum Disorders
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Joint attention; Circumscribed interests; Generalization; Autism
ID OF-THE-LITERATURE; YOUNG-CHILDREN; BEHAVIORS; INTERVENTION;
COMMUNICATION; PLAY
AB Joint attention occurs when two people engage in eye contact, verbalizations, or gestures between each other and a common object for the purpose of social interaction. Interventions which embedded participant's circumscribed interests (i.e., specific topics or themes of abnormal intensity) in materials found increases in joint attention without direct intervention. Previous joint attention intervention successfully taught three children with autism to respond to others' joint attention directives using interventions with circumscribed interest-related materials. However, initiating joint attention and generalization across materials and settings were not addressed. The current study investigated the effectiveness of prompt fading and reinforcement while engaging in circumscribed interest-related activities on initiating joint attention for three children with autism. All children acquired joint attention initiations; however, only two did so while engaging with circumscribed interest-related materials. Participants demonstrated variable generalization across activities, partners, and settings. Parents reported declines in circumscribed interest-related social interference from pre- to post-intervention. Results suggest teaching joint attention initiations using circumscribed interest-related materials to teach joint attention initiations may be an effective strategy for some children with autism. Future research implications are discussed.
C1 [Kryzak, Lauren A.; Jones, Emily A.] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA.
[Kryzak, Lauren A.; Jones, Emily A.] CUNY, Grad Ctr, New York, NY 10016 USA.
RP Kryzak, LA (reprint author), CUNY, Grad Ctr, 365 Fifth Ave, New York, NY 10016 USA.
EM lauren.kryzak@qc.cuny.edu
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Whalen C, 2003, J CHILD PSYCHOL PSYC, V44, P456, DOI 10.1111/1469-7610.00135
Yoder P, 2006, J CONSULT CLIN PSYCH, V74, P426, DOI 10.1037/0022-006X.74.3.426
NR 31
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2015
VL 27
IS 3
BP 265
EP 284
DI 10.1007/s10882-014-9414-0
PG 20
WC Rehabilitation
SC Rehabilitation
GA CI1FC
UT WOS:000354487000001
ER
PT J
AU Carlon, S
Carter, M
Stephenson, J
AF Carlon, Sarah
Carter, Mark
Stephenson, Jennifer
TI Decision-Making Regarding Early Intervention by Parents of Children with
Autism Spectrum Disorder
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE ASD; Autism; Decision-making; Intervention; Parent; Treatment
ID ALTERNATIVE MEDICINE; COMPLEMENTARY; EXPERIENCES; MODELS
AB Seventy-five parents of preschool-age children with autism spectrum disorder (ASD) completed surveys designed to identify factors considered when selecting an intervention approach for their child and to elucidate the relative importance of those factors in the decision-making process. For decisions to use interventions, the most important factor related to the individual needs of the child. This factor and several others; including staff attributes, whether the intervention was ASD-specific, and intuition/gut feelings, were weighted more highly than research evidence in both decisions to use and to reject interventions. When the individual factors were grouped pragmatically, the category representing service characteristics, including staff attributes and whether the intervention was ASD-specific, was ranked significantly higher in importance than all other categories. Advice/recommendations from others have been reported in previous research as being frequently considered in parental decision-making. However, in the present study, advice and recommendations from others was rated significantly lower in importance than all other categories regardless of whether participants were considering using or rejecting an intervention.
C1 [Carlon, Sarah; Carter, Mark; Stephenson, Jennifer] Macquarie Univ, Sydney, NSW 2109, Australia.
RP Carlon, S (reprint author), Macquarie Univ, Sydney, NSW 2109, Australia.
EM carlon.sj@gmail.com
CR Al Anbar NN, 2010, RES DEV DISABIL, V31, P817, DOI 10.1016/j.ridd.2010.02.007
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Bowker A, 2011, J AUTISM DEV DISORD, V41, P1373, DOI 10.1007/s10803-010-1164-y
Carlon S., 2014, AUSTRALASIA IN PRESS
Carlon S, 2013, RES AUTISM SPECT DIS, V7, P369, DOI 10.1016/j.rasd.2012.10.009
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National Autism Center, 2009, NAT AUT CTR NAT STAN
Odom SL, 2010, J AUTISM DEV DISORD, V40, P425, DOI 10.1007/s10803-009-0825-1
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Prior M., 2011, REV RES IDENTITY MOS
Raising Children Network, 2011, MY CHILD HAS AUT SPE
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Smith T, 2000, BEHAV INTERVENT, V15, P83, DOI 10.1002/(SICI)1099-078X(200004/06)15:2<83::AID-BIN47>3.0.CO;2-W
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Stricker D, 2008, COMPUT METH PROG BIO, V92, P135, DOI 10.1016/j.cmpb.2008.06.010
Valentine K., 2010, OCCASIONAL PAPER NO
Valentine K, 2010, SOC SCI MED, V71, P950, DOI 10.1016/j.socscimed.2010.06.010
Wong HHL, 2006, J AUTISM DEV DISORD, V36, P901, DOI 10.1007/s10803-006-0131-0
NR 33
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2015
VL 27
IS 3
BP 285
EP 305
DI 10.1007/s10882-014-9415-z
PG 21
WC Rehabilitation
SC Rehabilitation
GA CI1FC
UT WOS:000354487000002
ER
PT J
AU McLay, L
van der Meer, L
Schafer, MCM
Couper, L
McKenzie, E
O'Reilly, MF
Lancioni, GE
Marschik, PB
Green, VA
Sigafoos, J
Sutherland, D
AF McLay, Laurie
van der Meer, Larah
Schaefer, Martina C. M.
Couper, Llyween
McKenzie, Emma
O'Reilly, Mark F.
Lancioni, Giulio E.
Marschik, Peter B.
Green, Vanessa A.
Sigafoos, Jeff
Sutherland, Dean
TI Comparing Acquisition, Generalization, Maintenance, and Preference
Across Three AAC Options in Four Children with Autism Spectrum Disorder
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Augmentative and alternative communication; Autism spectrum disorder;
Maintenance; Manual signing; Picture exchange; Preference;
Generalization; Requesting; Speech-generating device
ID SPEECH-GENERATING DEVICES; DEVELOPMENTAL-DISABILITIES; PICTURE EXCHANGE;
COMMUNICATION MODES; INDIVIDUALS; LANGUAGE; REQUESTS; PECS
AB We compared acquisition, generalization, maintenance, and preference for three AAC options. Four children with autism spectrum disorder were taught to use (a) a manual sign, (b) a picture exchange card, and (c) a speech-generating device to request toys. Intervention was staggered across children in a delayed multiple-probe design with acquisition and maintenance compared in an alternating treatments design. Generalization to new settings and people and preference for using each option were assessed. Three of the four children reached the acquisition criterion with each AAC option in 15 to 65 trials. One child learned to use the speech-generating device and picture exchange card in 20 and 40 trials, respectively, but failed to learn the manual sign. Two children showed generalization across settings and people with picture exchange and the speech-generating device and one child showed generalization with all three options. One child showed generalization across settings with the picture exchange card. Maintenance was relatively better with the speech-generating device and picture exchange card and the children most often chose the speech-generating device during the preference assessments. The results suggest comparable acquisition, but better generalization and maintenance with AAC options that involve selecting a graphic symbol.
C1 [McLay, Laurie; Schaefer, Martina C. M.; Couper, Llyween; McKenzie, Emma; Sutherland, Dean] Univ Canterbury, Coll Educ, Sch Hlth Sci, Christchurch 1, New Zealand.
[van der Meer, Larah; Green, Vanessa A.; Sigafoos, Jeff] Victoria Univ Wellington, Sch Educ, Wellington 6147, New Zealand.
[O'Reilly, Mark F.] Univ Texas Austin, Meadows Ctr Preventing Educ Risk, Austin, TX 78712 USA.
[Lancioni, Giulio E.] Univ Bari, Dept Neurosci & Sense Organs, Bari, Italy.
[Marschik, Peter B.] Med Univ Graz, Inst Physiol, iDN Interdisciplinary Dev Neurosci, Graz, Austria.
[Marschik, Peter B.] Karolinska Inst, Ctr Neurodev Disorders, Stockholm, Sweden.
RP Sigafoos, J (reprint author), Victoria Univ Wellington, Sch Educ, POB 17-310, Wellington 6147, New Zealand.
EM jeff.sigafoos@vuw.ac.nz
FU New Zealand Government through the Marsden Fund Council; Victoria
University of Wellington; University of Canterbury; New Zealand
Institute of Language, Brain Behaviour
FX The study was supported by a grant from the New Zealand Government
through the Marsden Fund Council, administered by the Royal Society of
New Zealand; and by Victoria University of Wellington, The University of
Canterbury, and The New Zealand Institute of Language, Brain &
Behaviour. We acknowledge and appreciate all the time and energy
contributed by the children, their families and school staff who
participated in this study.
CR Achmadi D, 2014, J DEV PHYS DISABIL, V26, P565, DOI 10.1007/s10882-014-9379-z
[Anonymous], 2013, NZSL ONL
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Duker P. C., 2004, ONE TO ONE TRAINING
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Kennedy C, 2005, SINGLE CASE DESIGNS
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NR 29
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2015
VL 27
IS 3
BP 323
EP 339
DI 10.1007/s10882-014-9417-x
PG 17
WC Rehabilitation
SC Rehabilitation
GA CI1FC
UT WOS:000354487000004
ER
PT J
AU Miltenberger, CA
Charlop, MH
AF Miltenberger, Catherine A.
Charlop, Marjorie H.
TI The Comparative Effectiveness of Portable Video Modeling vs. Traditional
Video Modeling Interventions with Children with Autism Spectrum
Disorders
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Autism; Video modeling; Social-communication skills; Technology
ID PRETEND PLAY; INTELLECTUAL DISABILITY; TEACHING-CHILDREN; STUDENTS;
SKILLS; SELF; TECHNOLOGIES; BEHAVIORS; FUTURE
AB Newly developed technologies are being incorporated into treatments for children with autism but there is only limited research examining how this affects child outcomes. In the present study, a multiple baseline design across children and an adapted alternating treatments design within child were used to compare the effectiveness of video modeling interventions implemented on the iPadA (R) to video modeling interventions implemented on the traditionally used television. Two targets were selected for each child and behaviors were randomly assigned to a treatment condition. Target behaviors were acquired and these behavior changes were found to be socially valid across treatment conditions. Four of the children required slightly more treatment sessions to acquire behaviors targeted on the iPadA (R). Generalization and maintenance were slightly higher following video modeling on the iPadA (R), but differences were inconsistent and unlikely to result in meaningfully different outcomes. These findings indicate that video modeling on the iPadA (R) does not result in improved child progress compared to traditional video modeling procedures. Additional research is needed to further examine the impact of using portable handheld devices when implementing video modeling interventions.
C1 [Miltenberger, Catherine A.] Claremont Grad Univ, Claremont, CA 91711 USA.
[Charlop, Marjorie H.] Claremont Mckenna Coll, Claremont, CA 91711 USA.
RP Miltenberger, CA (reprint author), Claremont Grad Univ, 850 Columbia Ave, Claremont, CA 91711 USA.
EM cmiltenberger@tbh.com
CR Allen K. D., 2010, EDUC TREAT CHILD, V33, P339, DOI DOI 10.1353/ETC.0.0101
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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Bellini S, 2007, EXCEPT CHILDREN, V73, P264
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Kagohara DM, 2012, RES AUTISM SPECT DIS, V6, P304, DOI 10.1016/j.rasd.2011.05.012
Kazdin A. E., 2005, ENCY STAT BEHAV SCI
Kubina R. M., 2005, EXCEPTIONALITY, V13, P35, DOI 10.1207/s15327035ex1301_5
LeBlanc L. A., 2004, J EARLY INTENSIVE BE, V1, P166
MacDonald R, 2005, BEHAV INTERVENT, V20, P225, DOI 10.1002/bin.197
MacDonald R, 2009, J APPL BEHAV ANAL, V42, P43, DOI 10.1901/jaba.2009.42-43
McCoy K., 2007, J ED TREATMENT CHILD, V30, P183
Mechling Linda C., 2012, Journal of Special Education Technology, V27
Mechling LC, 2012, J AUTISM DEV DISORD, V42, P2364, DOI 10.1007/s10803-012-1484-1
Petursdottir AL, 2007, J APPL BEHAV ANAL, V40, P353, DOI 10.1901/jaba.2007.160-05
Plavnick JB, 2011, J APPL BEHAV ANAL, V44, P747, DOI 10.1901/jaba.2011.44-747
Reichow B, 2008, J AUTISM DEV DISORD, V38, P1311, DOI 10.1007/s10803-007-0517-7
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Shipley-Benamou R, 2002, J POSIT BEHAV INTERV, V4, P165
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NR 35
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2015
VL 27
IS 3
BP 341
EP 358
DI 10.1007/s10882-014-9416-y
PG 18
WC Rehabilitation
SC Rehabilitation
GA CI1FC
UT WOS:000354487000005
ER
PT J
AU Johnson, CR
DeMand, A
Shui, A
AF Johnson, Cynthia R.
DeMand, Alexandra
Shui, Amy
TI Relationships Between Anxiety and Sleep and Feeding in Young Children
with ASD
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Autism; Autism spectrum disorder; Anxiety; Sleep; Feeding
ID AUTISM SPECTRUM DISORDERS; PERVASIVE DEVELOPMENTAL DISORDERS; TYPICALLY
DEVELOPING-CHILDREN; PRESCHOOL-CHILDREN; INTELLECTUAL DISABILITY;
PSYCHIATRIC-DISORDERS; HABITS QUESTIONNAIRE; SENSORY SENSITIVITY;
BEHAVIORAL-PROBLEMS; FOOD SELECTIVITY
AB The purpose of this study was to describe anxiety symptoms in a large sample of young children (ages 2-6 years of age) with ASD and examine the relationship of anxiety with other characteristics. This study included 118 children with an average age of nearly 4 years. Parents completed reports of anxiety symptoms, sleep, and feeding. Regression modeling was used to determine if elevated anxiety symptoms were related to age, cognitive functioning, diagnostic status, sleep, and feeding behaviors. Anxiety symptoms were present in 16-19 % of the sample. Anxiety symptoms predicted more sleep disturbance and were associated with a higher likelihood of elevated score on the feeding measure. Anxiety symptoms are present in young children with ASD more than in young typically developing children. Moreover, anxiety symptoms predicted sleep disturbances and, less robustly, increase the chances of feeding problem. Directions for further study and intervention implications are discussed.
C1 [Johnson, Cynthia R.] Univ Pittsburgh, Sch Med, Childrens Hosp Pittsburgh UPMC, Autism Ctr, Pittsburgh, PA 15213 USA.
[DeMand, Alexandra] Univ Pittsburgh, Pittsburgh, PA USA.
[Shui, Amy] Massachusetts Gen Hosp, Boston, MA 02114 USA.
RP Johnson, CR (reprint author), Univ Pittsburgh, Sch Med, Childrens Hosp Pittsburgh UPMC, Autism Ctr, 3420 5th Ave, Pittsburgh, PA 15213 USA.
EM Cynthia.Rheney.Johnson@gmail.com
FU Autism Speaks and cooperative agreement from HRSA [UA3 MC 11054];
National Center for Research Resources (NCRR), a component of the
National Institutes of Health (NIH) [ULI RR 024160]; NIH Roadmap for
Medical Research
FX Funding for this study was through Autism Speaks and cooperative
agreement (UA3 MC 11054) from HRSA to the Massachusetts General
Hospital. The views expressed in this presentation do not necessarily
reflect the views of Autism Speaks or HRSA. Additional support for this
study was through ULI RR 024160 from the National Center for Research
Resources (NCRR), a component of the National Institutes of Health (NIH)
and NIH Roadmap for Medical Research.
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NR 81
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2015
VL 27
IS 3
BP 359
EP 373
DI 10.1007/s10882-015-9419-3
PG 15
WC Rehabilitation
SC Rehabilitation
GA CI1FC
UT WOS:000354487000006
ER
PT J
AU Malmberg, DB
Charlop, MH
Gershfeld, SJ
AF Malmberg, Debra Berry
Charlop, Marjorie H.
Gershfeld, Sara J.
TI A Two Experiment Treatment Comparison Study: Teaching Social Skills to
Children with Autism Spectrum Disorder
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Autism Spectrum Disorder; Treatment comparison; Social skills; Social
behavior; Video modeling; Social stories; Prompting
ID TIME-DELAY; PERSPECTIVE-TAKING; IN-VIVO; VIDEO; STORIES; INTERVENTION;
PLAY; BEHAVIOR; DESIGN; REINFORCEMENT
AB The present study is a series of two experiments of treatment comparisons addressing the acquisition of social skills for children with Autism Spectrum Disorder (ASD). In Experiment 1, a multi-element design was used to assess the efficacy of video modeling as compared with Social Stories (TM) to teach various social skills to the children with ASD. Results from video modeling yielded positive and quick acquisition, consistent with previous literature. However, treatment with Social Stories did not. Upon close inspection of the Social Stories literature, it became apparent that most effective social stories interventions were treatment packages, which include well-tested behavioral procedures such as prompting. Therefore, Experiment 2 was designed to compare Social Stories with the components most often used in social stories treatment packages, such as prompting, parceled out, to assess variables functional for behavior change. A multiple baseline design across children was used. Results of Exp. 2 suggested that prompting was effective for the children in the present study. Results of both experiments are discussed in terms of relating these results to previous literature, and ultimately to recommending treatment for social skills for children with ASD.
C1 [Malmberg, Debra Berry] Calif State Univ Northridge, Dept Psychol, Northridge, CA 91330 USA.
[Charlop, Marjorie H.] Claremont Mckenna Coll, Dept Psychol, Claremont, CA 91711 USA.
[Gershfeld, Sara J.] Scripps Coll, Dept Psychol, Claremont, CA 91711 USA.
RP Malmberg, DB (reprint author), Calif State Univ Northridge, Dept Psychol, 18111 Nordhoff St, Northridge, CA 91330 USA.
EM dmalmberg@csun.edu
FU College of Social and Behavioral Sciences, California State University,
Northridge
FX This research was supported by the College of Social and Behavioral
Sciences, California State University, Northridge. The authors would
like to thank Amanda Finch, James Vogel, Rachel Travolta, Gina Chang,
Kari Berquist, Sabrina Daneshvar, Alissa Greenberg, Denise Grosberg,
Julyana Garcia, the research assistants at the CSUN Autism Clinic, and
the children and families who participated.
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Wang PS, 2009, EDUC TRAIN DEV DISAB, V44, P318
NR 57
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2015
VL 27
IS 3
BP 375
EP 392
DI 10.1007/s10882-015-9420-x
PG 18
WC Rehabilitation
SC Rehabilitation
GA CI1FC
UT WOS:000354487000007
ER
PT J
AU Chen, M
McComas, JJ
Reichle, JE
Bergmann, JA
AF Chen, Mo
McComas, Jennifer J.
Reichle, Joe E.
Bergmann, Jonathan A.
TI Brief Component Analysis to Identify the Active Variable in the
Maintenance of Tolerance for Delay of Reinforcement Intervention for an
Adolescent with Autism
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Autism; Tolerance for delay of reinforcement; Explicit delay cue;
General delay cue; Component analysis
ID DEVELOPMENTAL-DISABILITIES; BEHAVIOR PROBLEMS; REDUCTION
AB This study adopted a brief component analysis to examine the active variable in a tolerance for delay of reinforcement (TFD) intervention procedure to decrease tangible-maintained problem behavior for a male adolescent with autism. Antecedent-based functional analysis suggested that problem behavior occurred most when access to tangible items or activities was restricted. With the introduction of a TFD intervention procedure using a combination of a general delay cue and an explicit delay cue, the learner's problem behavior decreased to a low level and he quickly learned to wait for access to preferred items for 10 min with no problem behavior. Two weeks after the learner met the mastery criterion, a component analysis was conducted through a brief ABA withdrawal design, to separate the relative contributions of the general delay cue and the explicit delay cue in the maintenance of the TFD intervention. The combination of general and explicit delay cues resulted in low levels of problem behavior and higher toleration of delays to reinforcement relative to the general delay cue alone. Implications and limitations are discussed.
C1 [Chen, Mo; McComas, Jennifer J.; Reichle, Joe E.; Bergmann, Jonathan A.] Univ Minnesota, Twin Cities, Minneapolis, MN 55455 USA.
RP Chen, M (reprint author), Univ Minnesota, Twin Cities, 274 Educ Sci Bldg,56 River Rd, Minneapolis, MN 55455 USA.
EM chen1641@umn.edu
CR Anderson CM, 2002, J APPL BEHAV ANAL, V35, P137, DOI 10.1901/jaba.2002.35-137
Bruininks R., 1996, SCALES INDEPENDENT B
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Wechsler D., 2004, WECHSLER INTELLIGENC
NR 16
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2015
VL 27
IS 3
BP 393
EP 404
DI 10.1007/s10882-015-9422-8
PG 12
WC Rehabilitation
SC Rehabilitation
GA CI1FC
UT WOS:000354487000008
ER
PT J
AU Jang, JN
Matson, JL
AF Jang, Jina
Matson, Johnny L.
TI Autism Severity as a Predictor of Comorbid Conditions
SO JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
LA English
DT Article
DE Autism spectrum disorder; Severity; Comorbidity; Psychopathology;
Challenging behaviors
ID CHILDREN ASD-CC; SPECTRUM DISORDERS; CHALLENGING BEHAVIORS;
PSYCHIATRIC-DISORDERS; DIAGNOSTIC FIDELITY; DSM-IV; RELIABILITY;
SYMPTOMS; TODDLERS; CRITERIA
AB The relationship between autism spectrum disorders (ASD) and comorbid disorders has become an increasingly popular area of study. This trend has been spurred by the recognition that many physical and psychological problems are present when a diagnosis of ASD has been confirmed. This paper studied comorbid psychopathology and challenging behaviors of 207 individuals diagnosed with ASD between 2 and 16 years of age. More severe symptoms of ASD resulted in more symptoms on multiple comorbidities. The implications of these data are discussed.
C1 [Jang, Jina; Matson, Johnny L.] Louisiana State Univ, Baton Rouge, LA 70803 USA.
RP Jang, JN (reprint author), Louisiana State Univ, Baton Rouge, LA 70803 USA.
EM jinajang87@gmail.com
CR Blumburg S. L., 2011, NATL HLTH STAT REPOR, V65, P1
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Matson J. L., 2007, AUTISM SPECTRUM DISO
Matson JL, 2008, RES AUTISM SPECT DIS, V2, P237, DOI 10.1016/j.rasd.2007.06.003
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Matson JL, 2009, RES AUTISM SPECT DIS, V3, P345, DOI 10.1016/j.rasd.2008.08.002
Matson JL, 2009, RES DEV DISABIL, V30, P1107, DOI 10.1016/j.ridd.2009.06.003
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Thorson RT, 2012, RES AUTISM SPECT DIS, V6, P556, DOI 10.1016/j.rasd.2011.07.016
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Wu M. S., 2014, HDB AUTISM ANXIETY, P107
NR 45
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1056-263X
EI 1573-3580
J9 J DEV PHYS DISABIL
JI J. Dev. Phys. Disabil.
PD JUN
PY 2015
VL 27
IS 3
BP 405
EP 415
DI 10.1007/s10882-015-9421-9
PG 11
WC Rehabilitation
SC Rehabilitation
GA CI1FC
UT WOS:000354487000009
ER
PT J
AU Chantiluke, K
Barrett, N
Giampietro, V
Santosh, P
Brammer, M
Simmons, A
Murphy, DG
Rubia, K
AF Chantiluke, Kaylita
Barrett, Nadia
Giampietro, Vincent
Santosh, Paramala
Brammer, Michael
Simmons, Andrew
Murphy, Declan G.
Rubia, Katya
TI Inverse fluoxetine effects on inhibitory brain activation in
non-comorbid boys with ADHD and with ASD
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE ADHD; ASD; Motor response inhibition; Stop task; fMRI; Serotonin;
Fluoxetine
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS; AUTISTIC SPECTRUM
DISORDERS; HIGH-FUNCTIONING AUTISM; RESPONSE-INHIBITION; TRYPTOPHAN
DEPLETION; REPETITIVE BEHAVIOR; PLATELET SEROTONIN; ERROR-DETECTION
AB Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are often comorbid and have both performance and brain dysfunctions during motor response inhibition. Serotonin agonists modulate motor response inhibition and have shown positive behavioural effects in both disorders.
We therefore used functional magnetic resonance imaging (fMRI) to investigate the so far unknown shared and disorder-specific inhibitory brain dysfunctions in these two disorders, as well as the effects of a single dose of the selective serotonin reuptake inhibitor fluoxetine.
Age-matched boys with ADHD (18), ASD (19) and healthy controls (25) were compared with fMRI during a stop task measuring motor inhibition. Patients were scanned twice, under either an acute dose of fluoxetine or placebo in a double-blind, placebo-controlled randomised design. Repeated measures analyses within patients assessed drug effects. To test for potential normalisation effects of brain dysfunctions, patients under each drug condition were compared to controls.
Under placebo, relative to controls, ASD boys showed overactivation in left and right inferior frontal cortex (IFC), while ADHD boys showed disorder-specific underactivation in orbitofrontal cortex (OFC) and basal ganglia. Under fluoxetine, the prefrontal dysfunctions were no longer observed, due to inverse effects of fluoxetine on these activations: fluoxetine downregulated IFC and OFC activation in ASD but upregulated them in ADHD.
The findings show that fluoxetine normalises frontal lobe dysfunctions in both disorders via inverse effects, downregulating abnormally increased frontal activation in ASD and upregulating abnormally decreased frontal activation in ADHD, potentially reflecting inverse baseline serotonin levels in both disorders.
C1 [Chantiluke, Kaylita; Santosh, Paramala; Rubia, Katya] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, MRC Ctr Social Genet & Dev Psychiat SGDP, London SE5 8AF, England.
[Barrett, Nadia] South London & Maudsley NHS Trust, London, England.
[Giampietro, Vincent; Brammer, Michael; Simmons, Andrew] Kings Coll London, Inst Psychiat, Dept Neuroimaging, London SE5 8AF, England.
[Simmons, Andrew] Kings Coll London, South London & Maudsley NHS Trust, NIHR Biomed Res Ctr Mental Hlth, London SE5 8AF, England.
[Simmons, Andrew] Kings Coll London, Inst Psychiat, London SE5 8AF, England.
[Murphy, Declan G.] Kings Coll London, Dept Forens & Dev Sci, London SE5 8AF, England.
[Murphy, Declan G.] Kings Coll London, Inst Psychiat, Sackler Inst Translat Neurodev, London SE5 8AF, England.
RP Rubia, K (reprint author), Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, MRC Ctr Social Genet & Dev Psychiat SGDP, 16 De Crespigny Pk,PO46, London SE5 8AF, England.
EM katya.rubia@kcl.ac.uk
RI Simmons, Andrew/B-8848-2008
OI Simmons, Andrew/0000-0003-2306-5811
FU Lilly
FX Katya Rubia has received a funding from Lilly for another project and
speaker's honoraria from Lilly, Shire and Novartis. Michael Brammer is a
consultant for P1vital, Ltd, Oxford, UK.
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NR 78
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD JUN
PY 2015
VL 232
IS 12
BP 2071
EP 2082
DI 10.1007/s00213-014-3837-2
PG 12
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CI1DG
UT WOS:000354481000005
PM 25533997
ER
PT J
AU Ago, Y
Condro, MC
Tan, YV
Ghiani, CA
Colwell, CS
Cushman, JD
Fanselow, MS
Hashimoto, H
Waschek, JA
AF Ago, Yukio
Condro, Michael C.
Tan, Yossan-Var
Ghiani, Cristina A.
Colwell, Christopher S.
Cushman, Jesse D.
Fanselow, Michael S.
Hashimoto, Hitoshi
Waschek, James A.
TI Reductions in synaptic proteins and selective alteration of prepulse
inhibition in male C57BL/6 mice after postnatal administration of a VIP
receptor (VIPR2) agonist
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE VPAC2 receptor (VIPR2); Schizophrenia; Prepulse inhibition; PSD-95;
Synaptophysin; Mouse
ID CYCLASE-ACTIVATING POLYPEPTIDE; VASOACTIVE-INTESTINAL-PEPTIDE; LONG-TERM
POTENTIATION; SUPRACHIASMATIC NUCLEI; PREFRONTAL CORTEX;
GENE-EXPRESSION; CEREBRAL-CORTEX; DENTATE GYRUS; MUTANT MICE;
SCHIZOPHRENIA
AB An abundance of genetic and epidemiologic evidence as well as longitudinal neuroimaging data point to developmental origins for schizophrenia and other mental health disorders. Recent clinical studies indicate that microduplications of VIPR2, encoding the vasoactive intestinal peptide (VIP) receptor VPAC2, confer significant risk for schizophrenia and autism spectrum disorder. Lymphocytes from patients with these mutations exhibited higher VIPR2 gene expression and VIP responsiveness (cAMP induction), but mechanisms by which overactive VPAC2 signaling may lead to these psychiatric disorders are unknown.
We subcutaneously administered the highly selective VPAC2 receptor agonist Ro 25-1553 to C57BL/6 mice from postnatal day 1 (P1) to P14 to determine if overactivation of VPAC2 receptor signaling during postnatal brain maturation affects synaptogenesis and selected behaviors.
Western blot analyses on P21 revealed significant reductions of synaptophysin and postsynaptic density protein 95 (PSD-95) in the prefrontal cortex, but not in the hippocampus in Ro 25-1553-treated mice. The same postnatally restricted treatment resulted in a disruption in prepulse inhibition of the acoustic startle measured in adult mice. No effects were observed in open-field locomotor activity, sociability in the three-chamber social interaction test, or fear conditioning or extinction.
Overactivation of the VPAC2 receptor in the postnatal mouse results in a reduction in synaptic proteins in the prefrontal cortex and selective alterations in prepulse inhibition. These findings suggest that the VIPR2-linkage to mental health disorders may be due in part to overactive VPAC2 receptor signaling during a critical time of synaptic maturation.
C1 [Ago, Yukio; Condro, Michael C.; Ghiani, Cristina A.; Fanselow, Michael S.; Waschek, James A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.
[Ago, Yukio] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan.
[Tan, Yossan-Var] Univ Rouen, INSERM Unite Mixte Rech U905 IRIB, F-76183 Rouen, France.
[Colwell, Christopher S.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Lab Circadian & Sleep Med, Los Angeles, CA 90095 USA.
[Cushman, Jesse D.; Fanselow, Michael S.] Univ Calif Los Angeles, Brain Res Inst, Dept Psychol, Los Angeles, CA 90095 USA.
[Hashimoto, Hitoshi] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Mol Neuropharmacol, Suita, Osaka 5650871, Japan.
RP Waschek, JA (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, 635 Charles E Young Dr South, Los Angeles, CA 90095 USA.
EM jwaschek@mednet.ucla.edu
FU Simons Foundation; Program for Advancing Strategic International
Networks to Accelerate the Circulation of Talented Researchers (Japan)
[S2603]; National Institutes of Health [MH098506, HD04612]
FX We thank Dr. Felix E. Schweizer (UCLA) and Dr. Thomas J. O'Dell (UCLA)
for their kind gifts of anti-synaptophysin and anti-PSD-95 antibodies,
respectively. This study was supported in part by grants from Simons
Foundation, Program for Advancing Strategic International Networks to
Accelerate the Circulation of Talented Researchers (Grant No. S2603,
Japan) and National Institutes of Health (MH098506 and HD04612).
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NR 57
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD JUN
PY 2015
VL 232
IS 12
BP 2181
EP 2189
DI 10.1007/s00213-014-3848-z
PG 9
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CI1DG
UT WOS:000354481000014
PM 25575489
ER
PT J
AU Luan, R
Cheng, H
Li, L
Zhao, Q
Liu, H
Wu, ZZ
Zhao, LQ
Yang, JH
Hao, JL
Yin, ZN
AF Luan, Rong
Cheng, Hao
Li, Lin
Zhao, Qiang
Liu, Hui
Wu, Zhenzhou
Zhao, Liqing
Yang, Jinghua
Hao, Jianlei
Yin, Zhinan
TI Maternal Lipopolysaccharide Exposure Promotes Immunological Functional
Changes in Adult Offspring CD4(+) T Cells
SO AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
LA English
DT Article
DE CD4(+) T cells study; lipopolysaccharide; maternal immune activation;
mouse model; offspring immune response
ID IMMUNE ACTIVATION; TNF-ALPHA; AUTISM; MICE; INFLAMMATION; PREGNANCY;
RECEPTOR; LEADS; DIFFERENTIATION; PLASTICITY
AB ProblemMaternal immune activation (MIA) is a risk factor for autism and schizophrenia. However, how MIA affects offspring immune function remains unknown.
Method of studyTo investigate the effect of MIA on the offspring, pregnant C57BL/6J mice were given an intraperitoneal injection of 50g/kg lipopolysaccharide (LPS) on gestational day 12.5.
ResultsAdult LPS-treated offspring were hyper-reactive to LPS, and enhanced tumor necrosis factor- production was observed. CD4(+) T cells from LPS offspring had an elevated percentage of interferon (IFN)-(+)CD4(+) T cells and interleukin (IL)-17A(+)CD4(+) T cells in the spleen, IL-17A(+)CD4(+) T cells in the liver, and CD4(+)Foxp3(+) T cells in the spleen. LPS offspring CD4(+) T cells showed increased proliferation and an enhanced survival rate. DNA microarray analysis of resting LPS offspring CD4(+) T cells identified eight up-regulated genes, most of which encoded transcription factors. Quantitative liquid chromatography-mass spectrometry identified 18 up-regulated proteins in resting LPS offspring CD4(+) T cells and five up-regulated proteins in activated LPS offspring CD4(+) T cells, most of which participated in the PANTHER Gene Ontology metabolic process.
ConclusionsOur results showed that MIA to LPS up-regulated proteins involved in metabolic process in CD4(+) T cells from LPS offspring that might contribute to the hyperactivated immune response of adult LPS offspring.
C1 [Luan, Rong; Cheng, Hao; Liu, Hui; Wu, Zhenzhou; Zhao, Liqing; Yin, Zhinan] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.
[Hao, Jianlei; Yin, Zhinan] Jinan Univ, Int Immunol Ctr, Biomed Translat Res Inst, Guangzhou, Guangdong, Peoples R China.
[Li, Lin; Yang, Jinghua] Shandong Univ, Caner Res Ctr, Jinan 250100, Shandong, Peoples R China.
[Li, Lin] Binzhou Med Univ, Period Dept, Yantai, Shandong, Peoples R China.
[Zhao, Qiang] Nankai Univ, Coll Life Sci, Dept Zool & Dev Biol, Tianjin 300071, Peoples R China.
RP Yin, ZN (reprint author), Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, 94 Weijin Rd, Tianjin 300071, Peoples R China.
EM zhinan.yin@yale.edu
RI ahmed, Jamila/E-8653-2015
FU National High Technology Research and Development Program of China
[SS2014AA021601]; Major Program of the National Natural Science
Foundation of China [31230025]; International Science and Technology
Cooperation Program of China [2010DFB34000]; National Basic Research
Grant of China [2010CB529100]; National Natural Science Foundation of
China [31170858, 31370883, 31000400]; Natural Science Foundation of
Tianjin [12JCYBJC15700]
FX This work was supported by the National High Technology Research and
Development Program of China Grant SS2014AA021601 (863Program), Major
Program of the National Natural Science Foundation of China Grant
31230025 (to Dr. Zhinan Yin), International Science and Technology
Cooperation Program of China Grant 2010DFB34000 (to Dr. Zhinan Yin), and
National Basic Research Grant of China 2010CB529100. This work was also
supported by National Natural Science Foundation of China Grants
31170858 and 31370883 (to Dr. Liqing Zhao) and 31000400 (to Dr. Zhenzhou
Wu) and Natural Science Foundation of Tianjin Grant 12JCYBJC15700 (to
Dr. Qiang Zhao).
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NR 61
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1046-7408
EI 1600-0897
J9 AM J REPROD IMMUNOL
JI Am. J. Reprod. Immunol.
PD JUN
PY 2015
VL 73
IS 6
BP 522
EP 535
DI 10.1111/aji.12364
PG 14
WC Immunology; Reproductive Biology
SC Immunology; Reproductive Biology
GA CH9XN
UT WOS:000354390000005
ER
PT J
AU Slaughter, V
AF Slaughter, Virginia
TI Theory of Mind in Infants and Young Children: A Review
SO AUSTRALIAN PSYCHOLOGIST
LA English
DT Article
DE childhood; infancy; mindreading; review; theory of mind; review
ID TYPICALLY DEVELOPING-CHILDREN; AUTISM SPECTRUM; FALSE BELIEF;
INDIVIDUAL-DIFFERENCES; MENTAL STATE; ACTION ANTICIPATION; ASPERGER
SYNDROME; MOTHERS; ATTRIBUTION; BEHAVIOR
AB Theory of mind, or mindreading, refers to our uniquely human capacity to infer what is in other people's minds. Recent research suggests that implicit elements of this ability can be seen as early as the second year of life, in infants' spontaneous helping, communicative, and eye-gaze behaviours. More explicit verbally mediated mindreading skills emerge in the preschool period, and these are positively linked to social competence. Research with typically developing children as well as those with autism spectrum disorders suggests that exposure to conversation about mental states promotes theory of mind development.
C1 Univ Queensland, Sch Psychol, Brisbane, Qld 4070, Australia.
RP Slaughter, V (reprint author), Univ Queensland, Sch Psychol, Brisbane, Qld 4070, Australia.
EM vps@psy.uq.edu.au
CR Adrian JE, 2005, J CHILD LANG, V32, P673, DOI 10.1017/S0305000905006963
Bang J, 2013, J AUTISM DEV DISORD, V43, P1732, DOI 10.1007/s10803-012-1716-4
Brophy M., 2005, WHY LANGUAGE MATTERS, P50, DOI DOI 10.1093/ACPROF:OSO/9780195159912.003.0003
de Rosnay M, 2014, J CHILD LANG, V41, P1179, DOI 10.1017/S0305000913000433
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Slaughter V., META ANALYSIS OF THE
Southgate V, 2007, PSYCHOL SCI, V18, P587, DOI 10.1111/j.1467-9280.2007.01944.x
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NR 33
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0005-0067
EI 1742-9544
J9 AUST PSYCHOL
JI Aust. Psychol.
PD JUN
PY 2015
VL 50
IS 3
BP 169
EP 172
DI 10.1111/ap.12080
PG 4
WC Psychology, Multidisciplinary
SC Psychology
GA CH3UO
UT WOS:000353956100001
ER
PT J
AU Tanchanco, L
De Vera, M
Bernal, S
Bengzon, A
AF Tanchanco, L.
De Vera, M.
Bernal, S.
Bengzon, A.
TI EFFECT OF MESENCHYMAL STEM CELL TREATMENT ON AUTISM SPECTRUM DISORDER
SO CYTOTHERAPY
LA English
DT Meeting Abstract
C1 [Tanchanco, L.; De Vera, M.; Bernal, S.; Bengzon, A.] Med City Hosp, Pasig, Philippines.
[Tanchanco, L.; De Vera, M.; Bengzon, A.] Ateneo Sch Med & Publ Hlth, Pasig, Philippines.
RI ahmed, Jamila/E-8653-2015
NR 0
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1465-3249
EI 1477-2566
J9 CYTOTHERAPY
JI Cytotherapy
PD JUN
PY 2015
VL 17
IS 6
SU S
MA 134
BP S39
EP S40
PG 2
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology; Hematology; Medicine, Research & Experimental
SC Cell Biology; Biotechnology & Applied Microbiology; Hematology; Research
& Experimental Medicine
GA CH6JK
UT WOS:000354142700125
ER
PT J
AU Treasure, J
Stein, D
Maguire, S
AF Treasure, Janet
Stein, Daniel
Maguire, Sarah
TI Has the time come for a staging model to map the course of eating
disorders from high risk to severe enduring illness? An examination of
the evidence
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Review
DE biological markers; early intervention; eating disorders; epidemiology;
outcome
ID RANDOMIZED CONTROLLED-TRIAL; INTERPERSONAL MAINTENANCE MODEL; AUTISM
SPECTRUM DISORDERS; FEMALE COLLEGE-STUDENTS; SEVERE ANOREXIA-NERVOSA;
FAMILY-BASED TREATMENT; BULIMIA-NERVOSA; FOLLOW-UP; PREVENTION PROGRAM;
EARLY INTERVENTION
AB AimTo examine the evidence to support using a staging heuristic for eating disorders, suggesting that the diagnosis of an eating disorder follows a trajectory across the life course. Specifically, to examine whether high-risk markers and prodromal features presenting in childhood and adolescence can later transition to the full manifestation of the illness in early adulthood, and whether over time, the illness can be described as becoming severe and enduring, often resistant to treatment.
MethodsWe conducted a comprehensive literature search on the MEDLINE, PubMed, PsycINFO, EMBASE and Cochrane databases from using the following terms: staging, duration of illness, early intervention, developmental epidemiology, neurobiological marker, phenotype, partial syndrome, severe enduring, chronic, prospective, longitudinal, cohort, epidemiology, adolescent, adult with anorexia nervosa, bulimia nervosa, binge eating disorder, eating disorder. The evidence was organized according to the staging heuristic defined by McGorry.
ResultsEvidence from epidemiological studies, neuropsychological findings, treatment responsivity and prognosis, support a specific staging trajectory for anorexia nervosa in that there is a longitudinal trajectory with evidence of neurobiological progression and evidence that interventions matched to stage of illness may optimize the benefit. There is less data at the moment to support such a model for bulimia nervosa and binge eating disorder.
ConclusionThe staging heuristic is a useful model for anorexia nervosa in terms of providing prognostic information and stage matched interventions. Although the evidence is encouraging, further research is needed before a similar model could be applied for bulimia nervosa and binge eating disorder.
C1 [Treasure, Janet] Kings Coll London, Inst Psychiat, Eating Disorders Res Unit PO59, London SE5 8AF, England.
[Stein, Daniel] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel.
[Stein, Daniel] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
[Maguire, Sarah] Univ Sydney, Ctr Eating & Dieting Disorders, Boden Inst, Sydney, NSW 2006, Australia.
RP Treasure, J (reprint author), Kings Coll London, Inst Psychiat, Eating Disorders Res Unit, P059,103 Denmark Hill, London SE5 8AF, England.
EM janet.treasure@kcl.ac.uk
RI ahmed, Jamila/E-8653-2015
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NR 138
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD JUN
PY 2015
VL 9
IS 3
BP 173
EP 184
DI 10.1111/eip.12170
PG 12
WC Psychiatry
SC Psychiatry
GA CH4FY
UT WOS:000353990400001
PM 25263388
ER
PT J
AU Kuechler, A
Zink, AM
Wieland, T
Ludecke, HJ
Cremer, K
Salviati, L
Magini, P
Najafi, K
Zweier, C
Czeschik, JC
Aretz, S
Endele, S
Tamburrino, F
Pinato, C
Clementi, M
Gundlach, J
Maylahn, C
Mazzanti, L
Wohlleber, E
Schwarzmayr, T
Kariminejad, R
Schlessinger, A
Wieczorek, D
Strom, TM
Novarino, G
Engels, H
AF Kuechler, Alma
Zink, Alexander M.
Wieland, Thomas
Luedecke, Hermann-Josef
Cremer, Kirsten
Salviati, Leonardo
Magini, Pamela
Najafi, Kimia
Zweier, Christiane
Czeschik, Johanna Christina
Aretz, Stefan
Endele, Sabine
Tamburrino, Federica
Pinato, Claudia
Clementi, Maurizio
Gundlach, Jasmin
Maylahn, Carina
Mazzanti, Laura
Wohlleber, Eva
Schwarzmayr, Thomas
Kariminejad, Roxana
Schlessinger, Avner
Wieczorek, Dagmar
Strom, Tim M.
Novarino, Gaia
Engels, Hartmut
TI Loss-of-function variants of SETD5 cause intellectual disability and the
core phenotype of microdeletion 3p25.3 syndrome
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID 3P DELETION SYNDROME; FUNCTION MUTATIONS; CRITICAL REGION; PATIENT;
FEATURES; GENETICS; SYSTEMS; AUTISM; DOMAIN
AB Intellectual disability (ID) has an estimated prevalence of 2-3%. Due to its extreme heterogeneity, the genetic basis of ID remains elusive in many cases. Recently, whole exome sequencing (WES) studies revealed that a large proportion of sporadic cases are caused by de novo gene variants. To identify further genes involved in ID, we performed WES in 250 patients with unexplained ID and their unaffected parents and included exomes of 51 previously sequenced child-parents trios in the analysis. Exome analysis revealed de novo intragenic variants in SET domain-containing 5 (SETD5) in two patients. One patient carried a nonsense variant, and the other an 81 bp deletion located across a splice-donor site. Chromosomal microarray diagnostics further identified four de novo non-recurrent microdeletions encompassing SETD5. CRISPR/Cas9 mutation modelling of the two intragenic variants demonstrated nonsense-mediated decay of the resulting transcripts, pointing to a loss-of-function (LoF) and haploinsufficiency as the common disease-causing mechanism of intragenic SETD5 sequence variants and SETD5-containing microdeletions. In silico domain prediction of SETD5, a predicted SET domain-containing histone methyltransferase (HMT), substantiated the presence of a SET domain and identified a novel putative PHD domain, strengthening a functional link to well-known histone-modifying ID genes. All six patients presented with ID and certain facial dysmorphisms, suggesting that SETD5 sequence variants contribute substantially to the microdeletion 3p25.3 phenotype. The present report of two SETD5 LoF variants in 301 patients demonstrates a prevalence of 0.7% and thus SETD5 variants as a relatively frequent cause of ID.
C1 [Kuechler, Alma; Luedecke, Hermann-Josef; Czeschik, Johanna Christina; Wieczorek, Dagmar] Univ Duisburg Essen, Inst Humangenet, Univ Klinikum Essen, Essen, Germany.
[Zink, Alexander M.; Cremer, Kirsten; Aretz, Stefan; Maylahn, Carina; Wohlleber, Eva; Engels, Hartmut] Univ Bonn, Inst Human Genet, D-53105 Bonn, Germany.
[Wieland, Thomas; Gundlach, Jasmin; Schwarzmayr, Thomas; Strom, Tim M.] Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany.
[Salviati, Leonardo; Pinato, Claudia; Clementi, Maurizio] Univ Padua, Clin Genet Unit, Dept Salute Donna & Bambino, Padua, Italy.
[Magini, Pamela] Univ Bologna, UO Genet Med, Dipartimento Sci Med & Chirug DIMEC, Bologna, Italy.
[Najafi, Kimia; Kariminejad, Roxana] Kariminejad Najmabadi Pathol & Genet Ctr, Tehran, Iran.
[Zweier, Christiane; Endele, Sabine] Univ Erlangen Nurnberg, Inst Human Genet, Erlangen, Germany.
[Tamburrino, Federica; Mazzanti, Laura] Univ Bologna, Policlin S Orsola Malpighi, Ambulatorio Auxol Sindromol & Malattie Rare, Dipartimento Sci Med & Chirug DIMEC, Bologna, Italy.
[Schlessinger, Avner] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA.
[Schlessinger, Avner] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
[Novarino, Gaia] IST Austria, Klosterneuburg, Austria.
RP Engels, H (reprint author), Univ Bonn, Inst Human Genet, Sigmund Freud Str 25, D-53105 Bonn, Germany.
EM hartmut.engels@uni-bonn.de
RI ahmed, Jamila/E-8653-2015
FU German Ministry of Research and Education (German Mental Retardation
Network) as part of the National Genome Research Network [01GS08164,
01GS08167, 01GS08163]; European Commission's FP7 CHERISH programme
[223692]
FX We are grateful to the patients and their families for participating in
this study. We thank the 'German Mental Retardation Network' (MRNET) and
Sabine Kaya, Daniela Falkenstein and Mike Liu for their excellent
technical assistance. This work was supported in part by the German
Ministry of Research and Education (grant numbers 01GS08164, 01GS08167,
01GS08163, German Mental Retardation Network) as part of the National
Genome Research Network and by the European Commission's FP7 CHERISH
programme (grant number 223692).
CR American Psychiatric Association AAP, 2013, DIAGN STAT MAN MENT, V5th
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NR 32
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
EI 1476-5438
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD JUN
PY 2015
VL 23
IS 6
BP 753
EP 760
DI 10.1038/ejhg.2014.165
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CI1BG
UT WOS:000354474600013
PM 25138099
ER
PT J
AU Mullegama, SV
Pugliesi, L
Burns, B
Shah, Z
Tahir, R
Gu, YH
Nelson, DL
Elsea, SH
AF Mullegama, Sureni V.
Pugliesi, Loren
Burns, Brooke
Shah, Zalak
Tahir, Raiha
Gu, Yanghong
Nelson, David L.
Elsea, Sarah H.
TI MBD5 haploinsufficiency is associated with sleep disturbance and
disrupts circadian pathways common to Smith-Magenis and fragile X
syndromes
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID AUTISM SPECTRUM DISORDER; 2Q23.1 MICRODELETION; DEVELOPMENTAL DELAY;
GENE; RAI1; CLOCK; MUTATIONS; PHENOTYPE; FEATURES; DUPLICATION
AB Individuals with autism spectrum disorders (ASD) who have an identifiable single-gene neurodevelopmental disorder (NDD), such as fragile X syndrome (FXS, FMR1), Smith-Magenis syndrome (SMS, RAI1), or 2q23.1 deletion syndrome (del 2q23.1, MBD5) share phenotypic features, including a high prevalence of sleep disturbance. We describe the circadian deficits in del 2q23.1 through caregiver surveys in which we identify several frequent sleep anomalies, including night/early awakenings, coughing/snoring loudly, and difficulty falling asleep. We couple these findings with studies on the molecular analysis of the circadian deficits associated with haploinsufficiency of MBD5 in which circadian gene mRNA levels of NR1D2, PER1, PER2, and PER3 were altered in del 2q23.1 lymphoblastoid cell lines (LCLs), signifying that haploinsufficiency of MBD5 can result in dysregulation of circadian rhythm gene expression. These findings were further supported by expression microarrays of MBD5 siRNA knockdown cells that showed significantly altered expression of additional circadian rhythm signaling pathway genes. Based on the common sleep phenotypes observed in del 2q23.1, SMS, and FXS patients, we explored the possibility that MBD5, RAI1, and FMR1 function in overlapping circadian rhythm pathways. Bioinformatic analysis identified conserved putative E boxes in MBD5 and RAI1, and expression levels of NR1D2 and CRY2 were significantly reduced in patient LCLs. Circadian and mTOR signaling pathways, both associated with sleep disturbance, were altered in both MBD5 and RAI1 knockdown microarray data, overlapping with findings associated with FMR1. These data support phenotypic and molecular overlaps across these syndromes that may be exploited to provide therapeutic intervention for multiple disorders.
C1 [Mullegama, Sureni V.; Gu, Yanghong; Nelson, David L.; Elsea, Sarah H.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Pugliesi, Loren; Burns, Brooke; Shah, Zalak; Tahir, Raiha; Elsea, Sarah H.] Virginia Commonwealth Univ, Sch Med, Dept Human & Mol Genet, Richmond, VA USA.
RP Elsea, SH (reprint author), Baylor Coll Med, Dept Mol & Human Genet, One Baylor Plaza,NAB2015, Houston, TX 77030 USA.
EM elsea@bcm.edu
FU Fondation Jerome Lejeune; Smith-Magenis Syndrome Research Foundation;
resources from Virginia Commonwealth University; Baylor College of
Medicine; Jan and Dan Duncan Neurological Research Institute at the
Texas Children's Hospital
FX We are grateful to PRISMS and to the 2q23.1 Facebook group and all of
the study participants and their families for their cooperation in this
study. We thank the Fondation Jerome Lejeune and the Smith-Magenis
Syndrome Research Foundation for funding portions of this study. This
work was supported, in part, by the resources from Virginia Commonwealth
University, Baylor College of Medicine, and the Jan and Dan Duncan
Neurological Research Institute at the Texas Children's Hospital.
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NR 39
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
EI 1476-5438
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD JUN
PY 2015
VL 23
IS 6
BP 781
EP 789
DI 10.1038/ejhg.2014.200
PG 9
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CI1BG
UT WOS:000354474600017
PM 25271084
ER
PT J
AU Beunders, G
de Munnik, SA
Van der Aa, N
Ceulemans, B
Voorhoeve, E
Groffen, AJ
Nillesen, WM
Meijers-Heijboer, EJ
Kooy, RF
Yntema, HG
Sistermans, EA
AF Beunders, Gea
de Munnik, Sonja A.
Van der Aa, Nathalie
Ceulemans, Berten
Voorhoeve, Els
Groffen, Alexander J.
Nillesen, Willy M.
Meijers-Heijboer, Elizabeth J.
Kooy, R. Frank
Yntema, Helger G.
Sistermans, Erik A.
TI Two male adults with pathogenic AUTS2 variants, including a two-base
pair deletion, further delineate the AUTS2 syndrome
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID AUTISM-SUSCEPTIBILITY-CANDIDATE-2 AUTS2; TRANSLOCATION BREAKPOINT;
INTELLECTUAL DISABILITY; DEVELOPMENTAL DELAY; SPECTRUM DISORDERS; GENE;
PATIENT; AUTISM
AB AUTS2 syndrome is characterized by low birth weight, feeding difficulties, intellectual disability, microcephaly and mild dysmorphic features. All affected individuals thus far were caused by chromosomal rearrangements, variants at the base pair level disrupting AUTS2 have not yet been described. Here we present the full clinical description of two affected men with intragenic AUTS2 variants (one two-base pair deletion in exon 7 and one deletion of exon 6). Both variants are de novo and are predicted to cause a frameshift of the full-length transcript but are unlikely to affect the shorter 30 transcript starting in exon 9. The similarities between the phenotypes of both men are striking and further support that AUTS2 syndrome is a single gene disorder.
C1 [Beunders, Gea; Voorhoeve, Els; Groffen, Alexander J.; Meijers-Heijboer, Elizabeth J.; Sistermans, Erik A.] Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet, NL-1081 BT Amsterdam, Netherlands.
[de Munnik, Sonja A.; Nillesen, Willy M.; Yntema, Helger G.] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands.
[Van der Aa, Nathalie; Kooy, R. Frank] Univ Antwerp Hosp, Dept Med Genet, Antwerp, Belgium.
[Ceulemans, Berten] Univ Antwerp Hosp, Dept Neurol Paediat Neurol, Antwerp, Belgium.
RP Sistermans, EA (reprint author), Vrije Univ Amsterdam, Med Ctr, Genome Diagnost, Boechorststr 7,J376, NL-1081 BT Amsterdam, Netherlands.
EM e.sistermans@vumc.nl
RI Groffen, Alexander/C-1118-2009
OI Groffen, Alexander/0000-0003-0046-4027
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NR 16
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
EI 1476-5438
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD JUN
PY 2015
VL 23
IS 6
BP 803
EP 807
DI 10.1038/ejhg.2014.173
PG 5
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CI1BG
UT WOS:000354474600020
PM 25205402
ER
PT J
AU Vojinovic, D
Adams, HHH
van der Lee, SJ
Ibrahim-Verbaas, CA
Brouwer, R
van den Hout, MCGN
Oole, E
van Rooij, J
Uitterlinden, A
Hofman, A
van IJcken, WFJ
Aartsma-Rus, A
van Ommen, GB
Ikram, MA
van Duijn, CM
Amin, N
AF Vojinovic, Dina
Adams, Hieab H. H.
van der Lee, Sven J.
Ibrahim-Verbaas, Carla A.
Brouwer, Rutger
van den Hout, Mirjam C. G. N.
Oole, Edwin
van Rooij, Jeroen
Uitterlinden, Andre
Hofman, Albert
van IJcken, Wilfred F. J.
Aartsma-Rus, Annemieke
van Ommen, GertJan B.
Ikram, M. Arfan
van Duijn, Cornelia M.
Amin, Najaf
TI The dystrophin gene and cognitive function in the general population
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID DUCHENNE MUSCULAR-DYSTROPHY; AUTISM SPECTRUM DISORDER; GABA(A)
RECEPTORS; WIDE ASSOCIATION; SEQUENCING DATA; BRAIN; EXPRESSION;
CHILDREN; PERFORMANCE; MALES
AB The aim of our study is to investigate whether single-nucleotide dystrophin gene (DMD) variants associate with variability in cognitive functions in healthy populations. The study included 1240 participants from the Erasmus Rucphen family (ERF) study and 1464 individuals from the Rotterdam Study (RS). The participants whose exomes were sequenced and who were assessed for various cognitive traits were included in the analysis. To determine the association between DMD variants and cognitive ability, linear (mixed) modeling with adjustment for age, sex and education was used. Moreover, Sequence Kernel Association Test (SKAT) was used to test the overall association of the rare genetic variants present in the DMD with cognitive traits. Although no DMD variant surpassed the prespecified significance threshold (P<1x10(-4)), rs147546024: A>G showed strong association (beta = 1.786, P-value = 2.56 x 10(-4)) with block-design test in the ERF study, while another variant rs1800273: G>A showed suggestive association (beta = -0.465, P-value = 0.002) with Mini-Mental State Examination test in the RS. Both variants are highly conserved, although rs147546024: A>G is an intronic variant, whereas rs1800273: G>A is a missense variant in the DMD which has a predicted damaging effect on the protein. Further gene-based analysis of DMD revealed suggestive association (P-values = 0.087 and 0.074) with general cognitive ability in both cohorts. In conclusion, both single variant and gene-based analyses suggest the existence of variants in the DMD which may affect cognitive functioning in the general populations.
C1 [Vojinovic, Dina; Adams, Hieab H. H.; van der Lee, Sven J.; Ibrahim-Verbaas, Carla A.; Uitterlinden, Andre; Hofman, Albert; Ikram, M. Arfan; van Duijn, Cornelia M.; Amin, Najaf] Erasmus Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands.
[Vojinovic, Dina] Univ Belgrade, Sch Med, Clin Neurol & Psychiat Children & Youth, Belgrade, Serbia.
[Adams, Hieab H. H.; Ikram, M. Arfan] Erasmus Univ, Med Ctr, Dept Radiol, NL-3000 CA Rotterdam, Netherlands.
[Brouwer, Rutger; van den Hout, Mirjam C. G. N.; Oole, Edwin; van IJcken, Wilfred F. J.] Erasmus MC, Ctr Biom, Rotterdam, Netherlands.
[van Rooij, Jeroen; Uitterlinden, Andre] Erasmus Univ, Med Ctr, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands.
[Uitterlinden, Andre; van Duijn, Cornelia M.] Netherlands Consortium Hlth Aging & Natl Genom In, Leiden, Netherlands.
[Aartsma-Rus, Annemieke; van Ommen, GertJan B.] Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands.
[van Ommen, GertJan B.; van Duijn, Cornelia M.] Ctr Med Syst Biol, Leiden, Netherlands.
[Ikram, M. Arfan] Erasmus Univ, Med Ctr, Dept Neurol, NL-3000 CA Rotterdam, Netherlands.
RP Vojinovic, D (reprint author), Erasmus Univ, Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM d.vojinovic@erasmusmc.nl
FU European Commission FP6 STRP grant [018947 (LSHG-CT-2006-01947)];
European Community's Seventh Framework Program (FP7)/European Commission
under program 'Quality of Life and Management of the Living Resources'
of 5th Framework Program [HEALTH-F4-2007-201413, QLG2-CT-2002-01254];
Russian Foundation for Basic Research [NWO-RFBR 047.017.043]; ZonMw
grant [91111025]; Ministry of Science of Serbia [175083];
Hersenstichting Nederland [F2013(1)-28]; Netherlands Organisation of
Scientific Research NWO Investments [175.010.2005.011, 911-03-012];
Research Institute for Diseases in Elderly [01493- 015, RIDE2];
Netherlands Genomics Initiative (NGI)/Netherlands Organisation for
Scientific Research (NWO) project [050-060-810]; Netherlands Consortium
for Healthy Ageing (NCHA); Erasmus Medical Center and Erasmus
University, Rotterdam; Research Institute for Diseases in the Elderly
(RIDE); Ministry of Education, Culture and Science; Ministry for Health,
Welfare and Sports; European Commission (DG XII); Municipality of
Rotterdam; Netherlands Organization for Scientific Research; Netherlands
Organization for the Health Research and Development (ZonMw)
FX Erasmus Rucphen Family study: The ERF study as a part of EUROSPAN
(European Special Populations Research Network) was supported by
European Commission FP6 STRP grant number 018947 (LSHG-CT-2006-01947)
and also received funding from the European Community's Seventh
Framework Program (FP7/2007-2013)/grant agreement HEALTH-F4-2007-201413
by the European Commission under the program 'Quality of Life and
Management of the Living Resources' of 5th Framework Program (no.
QLG2-CT-2002-01254). High-throughput analysis of the ERF data was
supported by joint grant from Netherlands Organization for Scientific
Research and the Russian Foundation for Basic Research (NWO-RFBR
047.017.043). Exome sequencing analysis in ERF was supported by the
ZonMw grant (project 91111025). We are grateful to all study
participants and their relatives, general practitioners and neurologists
for their contributions and to P Veraart for her help in genealogy, J
Vergeer for the supervision of the laboratory work and P Snijders for
his help in data collection. Dina Vojinovic is supported by the Ministry
of Science of Serbia (grant number 175083). Najaf Amin is supported by
the Hersenstichting Nederland (project number F2013(1)-28).Rotterdam
study: The generation and management of GWAS genotype data for the
Rotterdam Study are supported by the Netherlands Organisation of
Scientific Research NWO Investments (nr. 175.010.2005.011 and
911-03-012). This study is funded by the Research Institute for Diseases
in the Elderly (01493- 015; RIDE2), the Netherlands Genomics Initiative
(NGI)/Netherlands Organisation for Scientific Research (NWO) project nr.
050-060-810 and Netherlands Consortium for Healthy Ageing (NCHA). We
thank Pascal Arp, Mila Jhamai, Marijn Verkerk, Lizbeth Herrera and
Marjolein Peters for their help in creating the GWAS database, and Karol
Estrada and Maksim V Struchalin for their support in creation and
analysis of imputed data. The Rotterdam Study is funded by Erasmus
Medical Center and Erasmus University, Rotterdam, Netherlands
Organization for the Health Research and Development (ZonMw), the
Research Institute for Diseases in the Elderly (RIDE), the Ministry of
Education, Culture and Science, the Ministry for Health, Welfare and
Sports, the European Commission (DG XII), and the Municipality of
Rotterdam. We are grateful to the study participants, the staff from the
Rotterdam Study and the participating general practitioners and
pharmacists.
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NR 62
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
EI 1476-5438
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD JUN
PY 2015
VL 23
IS 6
BP 837
EP 843
DI 10.1038/ejhg.2014.183
PG 7
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CI1BG
UT WOS:000354474600025
PM 25227141
ER
PT J
AU Witmer, SE
Nasamran, A
Parikh, PJ
Schmitt, HA
Clinton, MC
AF Witmer, Sara E.
Nasamran, Amy
Parikh, Purvi J.
Schmitt, Heather A.
Clinton, Marianne C.
TI Using Parents and Teachers to Monitor Progress Among Children With ASD:
A Review of Intervention Research
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE assessment; autism spectrum disorders; behavior; communication;
socialization
ID CURRICULUM-BASED MEASUREMENT; GENERAL-EDUCATION CLASSROOM; AUTISM
SPECTRUM DISORDER; TERM SUCCESSFUL TREATMENT; SOCIAL-SKILLS;
STUDENT-ACHIEVEMENT; ASPERGER-SYNDROME; LEAST PROMPTS; YOUNG-CHILD;
BEHAVIOR
AB Despite growing knowledge of the effectiveness of various interventions for children with autism spectrum disorders (ASD), it is never clear whether a particular intervention will be effective for a specific child with ASD. Careful monitoring of an individual child's progress is necessary to know whether an intervention is effective. In this review, we examined intervention research studies focused on children with ASD in Grades K-12 that involve parents, teachers, and other school staff as data collectors. We describe the strategies that have been used in the 40 identified research studies to monitor progress in the areas of behavior and social communication. The results highlight monitoring strategies that may be helpful for parents and teachers to apply, and the discussion provides related suggestions to guide future research and practice.
C1 [Witmer, Sara E.; Nasamran, Amy; Schmitt, Heather A.; Clinton, Marianne C.] Michigan State Univ, E Lansing, MI 48824 USA.
[Parikh, Purvi J.] Univ Detroit Mercy, Detroit, MI 48221 USA.
RP Witmer, SE (reprint author), Michigan State Univ, 620 Farm Lane,Rm 434, E Lansing, MI 48824 USA.
EM sbolt@msu.edu
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NR 82
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2015
VL 30
IS 2
BP 67
EP 85
DI 10.1177/1088357614525659
PG 19
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA CH4RW
UT WOS:000354021600001
ER
PT J
AU Knight, VF
Wood, CL
Spooner, F
Browder, DM
O'Brien, CP
AF Knight, Victoria F.
Wood, Charles L.
Spooner, Fred
Browder, Diane M.
O'Brien, Christopher P.
TI An Exploratory Study Using Science eTexts With Students With Autism
Spectrum Disorder
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE supported electronic text; digital text; teaching science content;
universal design for learning; explicit instruction; ASD and
intellectual disability
ID SEVERE DEVELOPMENTAL-DISABILITIES; READING-COMPREHENSION;
LEARNING-DISABILITIES; INSTRUCTION; TECHNOLOGY; CHILDREN; INDIVIDUALS;
STRATEGIES; ABILITY; SKILLS
AB Supported electronic text (eText), or text altered to provide support, may promote comprehension of science content for students with disabilities. According to the Center for Applied Special Technology, Book Builder uses supported eText to promote reading for meaning for all students. Students with autism spectrum disorder experience difficulty comprehending science content because of the extensive amount of background knowledge required in conjunction with difficulties understanding abstract and figurative language. Investigations on the most effective methods for reading comprehension and teaching science to this population are equally limited. In this pilot study, feasibility was supported in high levels of treatment fidelity and teacher- and student-reported satisfaction. A multiple probe across participants with an embedded ABCD design was used to evaluate various modifications of Book Builder on measures of vocabulary, literal comprehension, and application questions. Considerations for students with ASD, limitations, and recommendations for future research conclude the article.
C1 [Knight, Victoria F.] Vanderbilt Univ, Nashville, TN 37203 USA.
[Wood, Charles L.; Spooner, Fred; Browder, Diane M.; O'Brien, Christopher P.] Univ N Carolina, Charlotte, NC 28223 USA.
RP Knight, VF (reprint author), Vanderbilt Univ, Peabody Coll, Dept Special Educ, One Magnolia Circle, Nashville, TN 37203 USA.
EM victoria.f.knight@vanderbilt.edu
FU University of Oregon [554902]; National Center for Supported eText
Dissertation Grants Program; U.S. Department of Education, Institute of
Education Sciences [R324AQ080014]
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: Support
for this research was provided in part by Grant No. 554902 from the
University of Oregon, National Center for Supported eText Dissertation
Grants Program awarded to the University of North Carolina at Charlotte,
and by Grant No. R324AQ080014 from the U.S. Department of Education,
Institute of Education Sciences, awarded to the University of North
Carolina at Charlotte.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 39
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2015
VL 30
IS 2
BP 86
EP 99
DI 10.1177/1088357614559214
PG 14
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA CH4RW
UT WOS:000354021600002
ER
PT J
AU Siegel, EB
Lien, SE
AF Siegel, Ellin B.
Lien, Susan E.
TI Using Photographs of Contrasting Contextual Complexity to Support
Classroom Transitions for Children With Autism Spectrum Disorders
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE autism; iPad; augmented input; contextual photographs
ID ACTIVITY SCHEDULES; SINGLE-SUBJECT; DESIGN
AB A single-subject, alternating treatment study compared the impact of two types of photograph displays of contrasting contextual complexity. The study examined the impact of high-context and no-context photographs, displayed on an iPad, on the ability of three preschool children with autism spectrum disorder (ASD) to transition to play activities. The influence of the two photograph types on the children's duration of transition time, number of prompts required, and type of prompts were measured. Results indicated that both photograph types provided helpful support for the children's transition time to play activities. Results for duration of transition time and number of prompts required during transitions suggest that the participant with more challenging needs performed more quickly and independently using high-context photographs. Results suggest the photographs that have contextual information matched to a child's needs can provide salient information and support their transition to activities in familiar settings.
C1 [Siegel, Ellin B.; Lien, Susan E.] Univ Nebraska, Lincoln, NE 68583 USA.
RP Siegel, EB (reprint author), Univ Nebraska, Dept Special Educ & Commun Disorders, 355 Barkley Mem Ctr, Lincoln, NE 68583 USA.
EM ellin.siegel@unl.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
BARLOW DH, 1979, J APPL BEHAV ANAL, V12, P199, DOI 10.1901/jaba.1979.12-199
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Mirenda P., 2013, AUGMENTATIVE ALTERNA, V4th
Mirenda P., 2009, AUTISM SPECTRUM DISO, P303
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NR 27
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2015
VL 30
IS 2
BP 100
EP 114
DI 10.1177/1088357614559211
PG 15
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA CH4RW
UT WOS:000354021600003
ER
PT J
AU Lopata, C
Toomey, JA
Thomeer, ML
McDonald, CA
Fox, JD
Smith, RA
Meichenbaum, DL
Volker, MA
Lee, GK
Lipinski, AM
AF Lopata, Christopher
Toomey, Jennifer A.
Thomeer, Marcus L.
McDonald, Christin A.
Fox, Jeffery D.
Smith, Rachael A.
Meichenbaum, David L.
Volker, Martin A.
Lee, Gloria K.
Lipinski, Alanna M.
TI Community Trial of a Comprehensive Psychosocial Treatment for HFASDs
SO FOCUS ON AUTISM AND OTHER DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE community effectiveness trial; manualized treatment; community
replication; comprehensive psychosocial intervention; high-functioning
autism spectrum disorders
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM; PERVASIVE
DEVELOPMENTAL DISORDERS; SOCIAL-SKILLS INTERVENTIONS;
ASPERGERS-SYNDROME; CHILDREN; EFFICACY; INDIVIDUALS
AB This community effectiveness trial examined the feasibility and efficacy of a comprehensive psychosocial treatment for 28 children, aged 7 to 10 years with high-functioning autism spectrum disorders (HFASDs). Treatment included instruction and therapeutic activities targeting social skills, face-emotion recognition skills, interest expansion, and interpretation of non-literal language skills. A behavioral program was instituted to foster skills acquisition and reduce ASD symptoms and problem behaviors. Feasibility was supported in high levels of fidelity and satisfaction. Significant improvements were found for the children's non-literal language skills and parent ratings of target social and communicative skills, broader social performance, and ASD symptoms. Secondary staff ratings corroborated parent ratings. Results suggest that the treatment, when administered by a community agency, was feasible and yielded positive outcomes similar to prior randomized clinical trials (RCTs).
C1 [Lopata, Christopher; Thomeer, Marcus L.; Lipinski, Alanna M.] Canisius Coll, Inst Autism Res, Buffalo, NY 14208 USA.
[Toomey, Jennifer A.; Meichenbaum, David L.] Summit Educ Resources, Getzville, NY USA.
[McDonald, Christin A.; Smith, Rachael A.; Volker, Martin A.; Lee, Gloria K.; Lipinski, Alanna M.] SUNY Buffalo, Buffalo, NY 14260 USA.
[McDonald, Christin A.] Nationwide Childrens Hosp, Columbus, OH USA.
[Fox, Jeffery D.] Autism Serv Inc, Williamsville, NY USA.
[Fox, Jeffery D.] Abil First Inc, Poughkeepsie, NY USA.
RP Lopata, C (reprint author), Canisius Coll, Inst Autism Res, Sci Hall 1016C,2001 Main St, Buffalo, NY 14208 USA.
EM lopatac@canisius.edu
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
Bauminger N, 2007, J AUTISM DEV DISORD, V37, P1593, DOI 10.1007/s10803-006-0245-4
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Carrow-Woolfolk E, 1999, COMPREHENSIVE ASSESS
Church C., 2000, FOCUS AUTISM OTHER D, V15, P12, DOI DOI 10.1177/108835760001500102
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Rutter M., 2003, SOCIAL COMMUNICATION
Scarpa A., 2013, CBT CHILDREN ADOLESC
Schultz R. T., 2005, HDB AUTISM PERVASIVE, V1, P515
Smith T, 2007, J AUTISM DEV DISORD, V37, P354, DOI 10.1007/s10803-006-0173-3
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White SW, 2007, J AUTISM DEV DISORD, V37, P1858, DOI 10.1007/s10803-006-0320-x
NR 38
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-3576
EI 1538-4829
J9 FOCUS AUTISM DEV DIS
JI Focus Autism Dev. Disabil.
PD JUN
PY 2015
VL 30
IS 2
BP 115
EP 125
DI 10.1177/1088357614525662
PG 11
WC Education, Special; Psychology, Developmental; Rehabilitation
SC Education & Educational Research; Psychology; Rehabilitation
GA CH4RW
UT WOS:000354021600004
ER
PT J
AU Stevens, WD
Tessler, MH
Peng, CS
Martin, A
AF Stevens, W. Dale
Tessler, Michael Henry
Peng, Cynthia S.
Martin, Alex
TI Functional Connectivity Constrains the Category-Related Organization of
Human Ventral Occipitotemporal Cortex
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE functional MRI; resting-state; tools; objects; scenes; parahippocampal
place area; hemispheric asymmetry; lateralization; concepts;
localization
ID FUSIFORM FACE AREA; SELECTIVE CORTICAL REGIONS; AUTISM SPECTRUM
DISORDERS; GLOBAL SIGNAL REGRESSION; RESTING HUMAN BRAIN; HUMAN OBJECT
AREAS; WORD FORM AREA; MANIPULATABLE OBJECTS; TEMPORAL CORTEX;
INDIVIDUAL VARIABILITY
AB One of the most robust and oft-replicated findings in cognitive neuroscience is that several spatially distinct, functionally dissociable ventral occipitotemporal cortex (VOTC) regions respond preferentially to different categories of concrete entities. However, the determinants of this category-related organization remain to be fully determined. One recent proposal is that privileged connectivity of these VOTC regions with other regions that store and/or process category-relevant properties may be a major contributing factor. To test this hypothesis, we used a multicategory functional magnetic resonance imaging (MRI) localizer to individually define category-related brain regions of interest (ROIs) in a large group of subjects (n=33). We then used these ROIs in resting-state functional connectivity MRI analyses to explore spontaneous functional connectivity among these regions. We demonstrate that during rest, distinct category-preferential VOTC regions show differentially stronger functional connectivity with other regions that have congruent category-preference, as defined by the functional localizer. Importantly, a tool-preferential region in the left medial fusiform gyrus showed differentially stronger functional connectivity with other left lateralized cortical regions associated with perceiving and knowing about common toolsposterior middle temporal gyrus (involved in perception of nonbiological motion), lateral parietal cortex (critical for reaching, grasping, manipulating), and ventral premotor cortex (involved in storing/executing motor programs)relative to other category-related regions in VOTC of both the right and left hemisphere. Our findings support the claim that privileged connectivity with other cortical regions that store and/or process category-relevant properties constrains the category-related organization of VOTC. Hum Brain Mapp 36:2187-2206, 2015. (c) Published 2015. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Stevens, W. Dale; Tessler, Michael Henry; Peng, Cynthia S.; Martin, Alex] NIMH, Sect Cognit Neuropsychol, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA.
RP Stevens, WD (reprint author), York Univ, Dept Psychol, Sherman Hlth Sci Res Ctr, 281 Ian Macdonald Blvd, Toronto, ON M3J 1P3, Canada.
EM stevensd@yorku.ca
FU National Institute of Mental Health, National Institutes of Health,
Division of Intramural Research
FX Contract grant sponsor: The National Institute of Mental Health,
National Institutes of Health, Division of Intramural Research.
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NR 83
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD JUN
PY 2015
VL 36
IS 6
BP 2187
EP 2206
DI 10.1002/hbm.22764
PG 20
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA CH4AF
UT WOS:000353972000013
PM 25704493
ER
PT J
AU Valk, SL
Di Martino, A
Milham, MP
Bernhardt, BC
AF Valk, Sofie L.
Di Martino, Adriana
Milham, Michael P.
Bernhardt, Boris C.
TI Multicenter Mapping of Structural Network Alterations in Autism
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE ASD; ABIDE; neocortex; connectivity; medial PFC; connectome
ID DORSOLATERAL PREFRONTAL CORTEX; SURFACE-BASED ANALYSIS; CORTICAL
THICKNESS; SPECTRUM DISORDERS; WHITE-MATTER; ORBITOFRONTAL CORTEX;
CEREBRAL-CORTEX; NEURAL BASIS; BRAIN; MRI
AB Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions primarily characterized by abnormalities in social cognition. Abundant previous functional MRI studies have shown atypical activity in networks encompassing medial prefrontal cortex (mPFC) and medial parietal regions corresponding to posterior cingulate cortex and precuneus (PCC/PCU). Conversely, studies assessing structural brain anomalies in ASD have been rather inconsistent. The current work evaluated whether structural changes in ASD can be reliability detected in a large multicenter dataset. Our comprehensive structural MRI framework encompassed cortical thickness mapping and structural covariance analysis based on three independent samples comprising individuals with ASD and controls (n=220), selected from the Autism Brain Imaging Data Exchange open-access database. Surface-based analysis revealed increased cortical thickness in ASD relative to controls in mPFC and lateral prefrontal cortex. Clusters encompassing mPFC were embedded in altered inter-regional covariance networks, showing decreased covariance in ASD relative to controls primarily to PCC/PCU and inferior parietal regions. Cortical thickness increases and covariance reductions in ASD were consistent, yet of variable effect size, across the different sites evaluated and measurable both in children and adults. Our multisite study shows regional and network-level structural alterations in mPFC in ASD that, possibly, relate to atypical socio-cognitive functions in this condition. Hum Brain Mapp 36:2364-2373, 2015. (c) 2015 Wiley Periodicals, Inc.
C1 [Valk, Sofie L.; Bernhardt, Boris C.] Max Planck Inst Human Cognit & Brain Sci, Dept Social Neurosci, D-04301 Leipzig, Germany.
[Di Martino, Adriana] NYU, Langone Med Ctr, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY USA.
[Di Martino, Adriana] NYU, Langone Med Ctr, Ctr Child Study, Autism Spectrum Disorder Res Program, New York, NY USA.
[Milham, Michael P.] Child Mind Inst, New York, NY USA.
[Milham, Michael P.] NYU, Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA.
[Bernhardt, Boris C.] Montreal Neurol Hosp & Inst, Brain Imaging Ctr, Montreal, PQ, Canada.
RP Bernhardt, BC (reprint author), Max Planck Inst Human Cognit & Brain Sci, Dept Social Neurosci, Stephanstr 1a, D-04301 Leipzig, Germany.
EM bernhardt@cbs.mpg.de
FU NIH (NYU site) [K23MH087770, R21MH084126, R01MH081218, R01HD065282];
Autism Speaks; Stavros Niarchos Foundation; Leon Levy Foundation; Autism
Speaks (PITT site) [04593]; KO1 NIMH [MH081191]; NIMH [MH67924]; NIH
[HD55748]; National Institutes of Health [K08 MH092697, RO1MH080826,
P50MH60450, T32DC008553, R01NS34783]; Autism Speaks Mentor-based
Predoctoral Fellowship (USM site) [1677]; University of Utah
Multidisciplinary Research Seed Grant; NRSA Predoctoral Fellowship [F31
DC010143]; Ben B. and Iris M. Margolis Foundation; Jeanne Timmins
Costello Award of the Montreal Neurological Institute and Hospital;
CIHR; International Max Planck Research School Stipend, IMPRS NeuroCom
FX Contract grant sponsor: NIH (NYU site); Contract grant numbers:
K23MH087770, R21MH084126, R01MH081218, R01HD065282; Contract grant
sponsor(s): Autism Speaks, The Stavros Niarchos Foundation, The Leon
Levy Foundation, an endowment provided by Phyllis Green and Randolph
Cowen; Contract grant sponsor: Autism Speaks (PITT site); Contract grant
number: 04593; Contract grant sponsor: KO1 NIMH; Contract grant number:
MH081191; Contract grant sponsor: NIMH; Contract grant number: MH67924;
Contract grant sponsor: NIH; Contract grant number: HD55748; Contract
grant sponsor: National Institutes of Health; Contract grant number(s):
K08 MH092697, RO1MH080826, P50MH60450, T32DC008553, R01NS34783; Contract
grant sponsor: Autism Speaks Mentor-based Predoctoral Fellowship (USM
site); Contract grant number: 1677; Contract grant sponsor: University
of Utah Multidisciplinary Research Seed Grant; Contract grant sponsor:
NRSA Predoctoral Fellowship; Contract grant number: F31 DC010143;
Contract grant sponsor: Ben B. and Iris M. Margolis Foundation; Contract
grant sponsor: Jeanne Timmins Costello Award of the Montreal
Neurological Institute and Hospital and CIHR (to B.C.B.); Contract grant
sponsor: International Max Planck Research School Stipend, IMPRS
NeuroCom (to S.L.V.).
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NR 69
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD JUN
PY 2015
VL 36
IS 6
BP 2364
EP 2373
DI 10.1002/hbm.22776
PG 10
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA CH4AF
UT WOS:000353972000025
PM 25727858
ER
PT J
AU St Pourcain, B
Haworth, CMA
Davis, OSP
Wang, K
Timpson, NJ
Evans, DM
Kemp, JP
Ronald, A
Price, T
Meaburn, E
Ring, SM
Golding, J
Hakonarson, H
Plomin, R
Smith, GD
AF St Pourcain, Beate
Haworth, C. M. A.
Davis, O. S. P.
Wang, Kai
Timpson, Nicholas J.
Evans, David M.
Kemp, John P.
Ronald, Angelica
Price, Tom
Meaburn, Emma
Ring, Susan M.
Golding, Jean
Hakonarson, Hakon
Plomin, R.
Smith, George Davey
TI Heritability and genome-wide analyses of problematic peer relationships
during childhood and adolescence
SO HUMAN GENETICS
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; DIFFICULTIES QUESTIONNAIRE; GENETIC
INFLUENCES; YOUNG ADULTHOOD; ASSOCIATION; ADJUSTMENT; STRENGTHS; TRAITS;
METAANALYSIS; POPULATION
AB Peer behaviour plays an important role in the development of social adjustment, though little is known about its genetic architecture. We conducted a twin study combined with a genome-wide complex trait analysis (GCTA) and a genome-wide screen to characterise genetic influences on problematic peer behaviour during childhood and adolescence. This included a series of longitudinal measures (parent-reported Strengths-and-Difficulties Questionnaire) from a UK population-based birth-cohort (ALSPAC, 4-17 years), and a UK twin sample (TEDS, 4-11 years). Longitudinal twin analysis (TEDS; N currency sign 7,366 twin pairs) showed that peer problems in childhood are heritable (4-11 years, 0.60 < twin-h (2) currency sign 0.71) but genetically heterogeneous from age to age (4-11 years, twin-r (g) = 0.30). GCTA (ALSPAC: N currency sign 5,608, TEDS: N currency sign 2,691) provided furthermore little support for the contribution of measured common genetic variants during childhood (4-12 years, 0.02 < GCTA-h (2)(Meta) currency sign 0.11) though these influences become stronger in adolescence (13-17 years, 0.14 < GCTA-h (2)(ALSPAC) currency sign 0.27). A subsequent cross-sectional genome-wide screen in ALSPAC (N currency sign 6,000) focussed on peer problems with the highest GCTA-heritability (10, 13 and 17 years, 0.0002 < GCTA-P currency sign 0.03). Single variant signals (P currency sign 10(-5)) were followed up in TEDS (N currency sign 2835, 9 and 11 years) and, in search for autism quantitative trait loci, explored within two autism samples (AGRE: N (Pedigrees) = 793; ACC: N (Cases) = 1,453/N (Controls) = 7,070). There was, however, no evidence for association in TEDS and little evidence for an overlap with the autistic continuum. In summary, our findings suggest that problematic peer relationships are heritable but genetically complex and heterogeneous from age to age, with an increase in common measurable genetic variation during adolescence.
C1 [St Pourcain, Beate; Timpson, Nicholas J.; Evans, David M.; Kemp, John P.; Ring, Susan M.; Smith, George Davey] Univ Bristol, MRC IEU, Bristol BS8 2BN, Avon, England.
[St Pourcain, Beate] Univ Bristol, Sch Oral & Dent Sci, Bristol BS8 2BN, Avon, England.
[St Pourcain, Beate] Univ Bristol, Sch Expt Psychol, Bristol BS8 2BN, Avon, England.
[St Pourcain, Beate; Timpson, Nicholas J.; Evans, David M.; Kemp, John P.; Ring, Susan M.; Golding, Jean; Smith, George Davey] Univ Bristol, Sch Social & Community Med, Bristol BS8 2BN, Avon, England.
[Haworth, C. M. A.] Univ Warwick, Dept Psychol, Coventry CV4 7AL, W Midlands, England.
[Haworth, C. M. A.; Davis, O. S. P.; Plomin, R.] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England.
[Davis, O. S. P.] UCL, Dept Genet Evolut & Environm, Genet Inst, London, England.
[Wang, Kai; Hakonarson, Hakon] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Wang, Kai] Univ So Calif, ZilkhaNeurogenet Inst, Los Angeles, CA USA.
[Wang, Kai] Univ So Calif, Dept Psychiat, Los Angeles, CA USA.
[Evans, David M.; Kemp, John P.] Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia.
[Ronald, Angelica; Meaburn, Emma] Univ London, Dept Psychol Sci, London, England.
[Price, Tom] Univ Penn, Sch Med, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA.
[Golding, Jean] Univ Bristol, Ctr Child & Adolescent Hlth, Bristol BS8 2BN, Avon, England.
RP St Pourcain, B (reprint author), Univ Bristol, MRC IEU, Oakfield House, Bristol BS8 2BN, Avon, England.
EM beate.stpourcain@bristol.ac.uk
FU UK Medical Research Council; Wellcome Trust [WT092731/Z/10/Z,
WT083431MA]; University of Bristol; Medical Research Council Integrative
Epidemiology Unit [MC_UU_12013/1-9]; Medical Research Council New
Investigator Award (MRC) [G0800582]; UK Medical Research Council
[G0901245, G19/2]; U.S. National Institutes of Health [HD044454,
HD059215]; Wellcome Trust Case Control Consortium [085475/B/08/Z,
085475/Z/08/Z]; British Academy; Sir Henry Wellcome Fellowship from the
Wellcome Trust [WT088984]; European Research Council [295366]; National
Institute of Mental Health [1U24MH081810]; [23]
FX The UK Medical Research Council and the Wellcome Trust
(WT092731/Z/10/Z), and the University of Bristol provided core support
for ALSPAC, and Autism Speaks (7132) provided support for the analysis
of autistic-trait related data. This work was also supported by the
Medical Research Council Integrative Epidemiology Unit
(MC_UU_12013/1-9). DME is supported by a Medical Research Council New
Investigator Award (MRC G0800582). JPK is funded by a Wellcome Trust
4-year PhD studentship (WT083431MA).We are extremely grateful to all the
families who took part in this study, the midwives for their help in
recruiting them, and the whole ALSPAC team, which includes interviewers,
computer and laboratory technicians, clerical workers, research
scientists, volunteers, managers, receptionists and nurses. ALSPAC GWAS
data were generated by the Sample Logistics and Genotyping Facilities at
the Wellcome Trust Sanger Institute and LabCorp (Laboratory Corporation
of America) using funding from 23 and Me.We are enormously grateful to
the twins, parents and the twins' teachers who have supported the Twins
Early Development Study (TEDS) for the past 18 years. The Twins Early
Development Study (TEDS) is supported by a program grant from the UK
Medical Research Council (G0901245, and previously G0500079), with
additional support from the U.S. National Institutes of Health
(HD044454, HD059215). Genome-wide genotyping was made possible by grants
from the Wellcome Trust Case Control Consortium 2 project
(085475/B/08/Z, 085475/Z/08/Z). C. M. A. Haworth was supported by a
research fellowship from the British Academy. O. S. P. Davis was
supported by a Sir Henry Wellcome Fellowship from the Wellcome Trust
(WT088984). R. Plomin was supported by a research professorship from the
UK Medical Research Council (G19/2) and a European Research Council
Advanced Investigator Award (295366).We gratefully acknowledge the
resources provided by the Autism Genetic Resource Exchange (AGRE)
Consortium and the participants of the AGRE and ACC resources. The
Autism Genetic Resource Exchange is a program of Autism Speaks and is
supported, in part, by grant 1U24MH081810 from the National Institute of
Mental Health to Clara M. Lajonchere (PI).
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NR 50
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
EI 1432-1203
J9 HUM GENET
JI Hum. Genet.
PD JUN
PY 2015
VL 134
IS 6
BP 539
EP 551
DI 10.1007/s00439-014-1514-5
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA CH7DQ
UT WOS:000354196200002
PM 25515860
ER
PT J
AU Davis, JM
Quick, VBS
Sikela, JM
AF Davis, J. M.
Quick, V. B. Searles
Sikela, J. M.
TI Replicated linear association between DUF1220 copy number and severity
of social impairment in autism
SO HUMAN GENETICS
LA English
DT Article
ID HEAD CIRCUMFERENCE; SPECTRUM DISORDERS; EVOLUTION; CHILDREN;
ABNORMALITIES; DUPLICATIONS; GENETICS; DOMAINS; 1Q21.1; GROWTH
AB Sequences encoding DUF1220 protein domains exhibit an exceptional human-specific increase in copy number and have been associated with several phenotypes related to brain size. Autism is a highly heritable and heterogeneous condition characterized behaviorally by social and communicative impairments, and increased repetitive and stereotyped behavior. Given the accelerated brain growth pattern observed in many individuals with autism, and the association between DUF1220 subtype CON1 copy number and brain size, we previously investigated associations between CON1 copy number and autism-related symptoms. We determined that CON1 copy number increase is associated with increasing severity of all three behavioral features of autism. The present study sought to replicate these findings in an independent population (N = 166). Our results demonstrate a replication of the linear relationship between CON1 copy number and the severity of social impairment in individuals with autism as measured by Autism Diagnostic Interview-Revised Social Diagnostic Score, such that with each additional copy of CON1 Social Diagnostic Score increased 0.24 points (SE = 0.11, p = 0.036). We also identified an analogous trend between CON1 copy number and Communicative Diagnostic Score, but did not replicate the relationship between CON1 copy number and Repetitive Behavior Diagnostic Score. Interestingly, these associations appear to be most pronounced in multiplex children. These results, representing the first replication of a gene dosage relationship with the severity of a primary symptom of autism, lend further support to the possibility that the same protein domain family implicated in the evolutionary expansion of the human brain may also be involved in autism severity.
C1 [Davis, J. M.; Quick, V. B. Searles; Sikela, J. M.] Univ Colorado, Dept Biochem & Mol Genet & Human Med Genet & Gen, Sch Med, Med Scientist Training Program, Aurora, CO 80045 USA.
[Davis, J. M.; Quick, V. B. Searles; Sikela, J. M.] Univ Colorado, Sch Med, Neurosci Program, Aurora, CO 80045 USA.
[Davis, J. M.] Univ Colorado, Sch Med, Dept Psychiat, Aurora, CO 80045 USA.
RP Sikela, JM (reprint author), Univ Colorado, Dept Biochem & Mol Genet & Human Med Genet & Gen, Sch Med, Med Scientist Training Program, Anschutz Med Campus, Aurora, CO 80045 USA.
EM James.Sikela@ucdenver.edu
FU NIH [R01 MH081203]; SFARI from Simons Foundation for Autism Research
[309230]; Colorado Clinical and Translational Science Institute (CCTSI)
Award [TL1 TR001081]
FX Funding for this work was provided by NIH grant R01 MH081203 (JMS), by
SFARI Pilot Grant 309230 from the Simons Foundation for Autism Research
(JMS), and by a Colorado Clinical and Translational Science Institute
(CCTSI) Award TL1 TR001081 (VBSQ). We gratefully acknowledge the
resources provided by the Autism Genetic Resource Exchange (AGRE)
Consortium and the participating AGRE families. We also thank Nathan
Anderson for excellent technical assistance.
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NR 42
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
EI 1432-1203
J9 HUM GENET
JI Hum. Genet.
PD JUN
PY 2015
VL 134
IS 6
BP 569
EP 575
DI 10.1007/s00439-015-1537-6
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA CH7DQ
UT WOS:000354196200004
PM 25758905
ER
PT J
AU Wang, Y
Su, PQ
Hu, B
Zhu, WJ
Li, QB
Yuan, P
Li, JC
Guan, XY
Li, FC
Jing, XY
Li, R
Zhang, YL
Ferec, C
Cooper, DN
Wang, J
Huang, DS
Chen, JM
Wang, YM
AF Wang, Ye
Su, Peiqiang
Hu, Bin
Zhu, Wenjuan
Li, Qibin
Yuan, Ping
Li, Jiangchao
Guan, Xinyuan
Li, Fucheng
Jing, Xiangyi
Li, Ru
Zhang, Yongling
Ferec, Claude
Cooper, David N.
Wang, Jun
Huang, Dongsheng
Chen, Jian-Min
Wang, Yiming
TI Characterization of 26 deletion CNVs reveals the frequent occurrence of
micro-mutations within the breakpoint-flanking regions and frequent
repair of double-strand breaks by templated insertions derived from
remote genomic regions
SO HUMAN GENETICS
LA English
DT Article
ID STRUCTURAL VARIATION; INHERITED DISEASE; GENE CONVERSION; MECHANISMS;
REARRANGEMENTS; REPLICATION; EVOLUTION; SPECTRUM; SIGNATURES; VARIANTS
AB Copy number variations (CNVs) have increasingly been reported to cause, or predispose to, human disease. However, a large fraction of these CNVs have not been accurately characterized at the single-base-pair level, thereby hampering a better understanding of the mutational mechanisms underlying CNV formation. Here, employing a composite pipeline method derived from various inference-based programs, we have characterized 26 deletion CNVs [including three novel pathogenic CNVs involving an autosomal gene (EXT2) causing hereditary osteochondromas and an X-linked gene (CLCN5) causing Dent disease, as well as 23 CNVs previously identified by inference from a cohort of Canadian autism spectrum disorder families] to the single-base-pair level of accuracy from whole-genome sequencing data. We found that breakpoint-flanking micro-mutations (within 22 bp of the breakpoint) are present in a significant fraction (5/26; 19 %) of the deletion CNVs. This analysis also provided evidence that a recently described error-prone form of DNA repair (i.e., repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome) not only causes human genetic disease but also impacts on human genome evolution. Our findings illustrate the importance of precise CNV breakpoint delineation for understanding the underlying mutational mechanisms and have implications for primer design in relation to the detection of deletion CNVs in clinical diagnosis.
C1 [Wang, Ye; Hu, Bin; Yuan, Ping; Li, Fucheng; Jing, Xiangyi; Wang, Yiming] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Med Genet, Guangzhou 510080, Guangdong, Peoples R China.
[Wang, Ye; Hu, Bin; Yuan, Ping; Li, Fucheng; Jing, Xiangyi; Wang, Yiming] Sun Yat Sen Univ, Ctr Genome Res, Guangzhou 510080, Guangdong, Peoples R China.
[Wang, Ye; Su, Peiqiang] Sun Yat Sen Univ, Dept Orthoped, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China.
[Zhu, Wenjuan; Li, Qibin; Wang, Jun; Wang, Yiming] BGI, Shenzhen 518083, Peoples R China.
[Yuan, Ping] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Guangzhou 510120, Guangdong, Peoples R China.
[Li, Jiangchao; Guan, Xinyuan] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol Southern China, Guangzhou 510060, Guangdong, Peoples R China.
[Li, Jiangchao] Guangdong Pharmaceut Univ, Vasc Biol Res Inst, Guangzhou 510006, Guangdong, Peoples R China.
[Guan, Xinyuan] Univ Hong Kong, Dept Clin Oncol, Hong Kong 999077, Hong Kong, Peoples R China.
[Jing, Xiangyi; Li, Ru; Zhang, Yongling] Guangzhou Med Univ, Prenatal Diagnost Ctr, Guangzhou Women & Children Med Ctr, Guangzhou 510623, Guangdong, Peoples R China.
[Ferec, Claude; Chen, Jian-Min] INSERM, U1078, F-29218 Brest, France.
[Ferec, Claude; Chen, Jian-Min] Etab Francais Sang EFS Bretagne, F-29218 Brest, France.
[Ferec, Claude; Chen, Jian-Min] Univ Bretagne Occidentale, Fac Med & Sci Sante, F-29238 Brest, France.
[Ferec, Claude] CHU Brest, Hop Morvan, Lab Genet Mol & Histocompatibilite, F-29609 Brest, France.
[Cooper, David N.] Cardiff Univ, Sch Med, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales.
[Wang, Jun] Univ Copenhagen, Dept Biol, Copenhagen, Denmark.
[Huang, Dongsheng] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Orthoped, Guangzhou 510120, Guangdong, Peoples R China.
RP Huang, DS (reprint author), Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Orthoped, Guangzhou 510120, Guangdong, Peoples R China.
EM huangdongshen18@hotmail.com; Jian-Min.Chen@univ-brest.fr;
ywzhong@hotmail.com
RI ahmed, Jamila/E-8653-2015
FU National Natural Science Foundation of China [31271342, 81371908,
81071703]; Ministry of Education of China [20110171110047]; Sun Yat-Sen
University [10ykyc07]; Basic Research Funds of the key Universities of
China [11ykzd10]; Institute National de la Sante et de la Recherche
Medicale (INSERM), France; BIOBASE GmbH; Cardiff University;
[NCET-12-0564]
FX This work was supported by the National Natural Science Foundation of
China [No. 31271342, No. 81371908, No. 81071703], the Ministry of
Education of China [20110171110047], the Sun Yat-Sen University [No.
10ykyc07], the NCET-12-0564 program and the Basic Research Funds of the
key Universities of China [11ykzd10], and the Institute National de la
Sante et de la Recherche Medicale (INSERM), France. DNC receives
financial support from BIOBASE GmbH through a license agreement with
Cardiff University.
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Chen JM, 2007, NAT REV GENET, V8, P762, DOI 10.1038/nrg2193
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NR 37
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
EI 1432-1203
J9 HUM GENET
JI Hum. Genet.
PD JUN
PY 2015
VL 134
IS 6
BP 589
EP 603
DI 10.1007/s00439-015-1539-4
PG 15
WC Genetics & Heredity
SC Genetics & Heredity
GA CH7DQ
UT WOS:000354196200006
PM 25792359
ER
PT J
AU Aida, T
Yoshida, J
Nomura, M
Tanimura, A
Iino, Y
Soma, M
Bai, N
Ito, Y
Cui, WP
Aizawa, H
Yanagisawa, M
Nagai, T
Takata, N
Tanaka, KF
Takayanagi, R
Kano, M
Gotz, M
Hirase, H
Tanaka, K
AF Aida, Tomomi
Yoshida, Junichi
Nomura, Masatoshi
Tanimura, Asami
Iino, Yusuke
Soma, Miho
Bai, Ning
Ito, Yukiko
Cui, Wanpeng
Aizawa, Hidenori
Yanagisawa, Michiko
Nagai, Terumi
Takata, Norio
Tanaka, Kenji F.
Takayanagi, Ryoichi
Kano, Masanobu
Goetz, Magdalena
Hirase, Hajime
Tanaka, Kohichi
TI Astroglial Glutamate Transporter Deficiency Increases Synaptic
Excitability and Leads to Pathological Repetitive Behaviors in Mice
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
ID OBSESSIVE-COMPULSIVE DISORDER; NMDA RECEPTOR ANTAGONISTS;
TOURETTE-SYNDROME; ANIMAL-MODELS; MUTANT MICE; GLAST; CIRCUITRY; AUTISM;
PATHOPHYSIOLOGY; SCHIZOPHRENIA
AB An increase in the ratio of cellular excitation to inhibition (E/I ratio) has been proposed to underlie the pathogenesis of neuropsychiatric disorders, such as autism spectrum disorders (ASD), obsessive-compulsive disorder (OCD), and Tourette's syndrome (TS). A proper E/I ratio is achieved via factors expressed in neuron and glia. In astrocytes, the glutamate transporter GLT1 is critical for regulating an E/I ratio. However, the role of GLT1 dysfunction in the pathogenesis of neuropsychiatric disorders remains unknown because mice with a complete deficiency of GLT1 exhibited seizures and premature death. Here, we show that astrocyte-specific GLT1 inducible knockout (GLAST(CreERT2/+)/GLT(1flox/flox), iKO) mice exhibit pathological repetitive behaviors including excessive and injurious levels of self-grooming and tic-like head shakes. Electrophysiological studies reveal that excitatory transmission at corticostriatal synapse is normal in a basal state but is increased after repetitive stimulation. Furthermore, treatment with an N-methyl-D-aspartate (NMDA) receptor antagonist memantine ameliorated the pathological repetitive behaviors in iKO mice. These results suggest that astroglial GLT1 has a critical role in controlling the synaptic efficacy at corticostriatal synapses and its dysfunction causes pathological repetitive behaviors.
C1 [Aida, Tomomi; Yoshida, Junichi; Iino, Yusuke; Soma, Miho; Bai, Ning; Ito, Yukiko; Cui, Wanpeng; Aizawa, Hidenori; Yanagisawa, Michiko; Tanaka, Kohichi] Tokyo Med & Dent Univ, Med Res Inst, Lab Mol Neurosci, Tokyo 1138510, Japan.
[Nomura, Masatoshi; Takayanagi, Ryoichi] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 812, Japan.
[Tanimura, Asami; Kano, Masanobu] Univ Tokyo, Grad Sch Med, Dept Neurophysiol, Tokyo, Japan.
[Nagai, Terumi; Takata, Norio] RIKEN, Brain Sci Inst, Lab Neuron Glia Circuitry, Saitama, Japan.
[Tanaka, Kenji F.; Hirase, Hajime] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan.
[Goetz, Magdalena] Univ Munich, Inst Physiol, Physiol Genom, D-80539 Munich, Germany.
[Tanaka, Kohichi] JST, CREST, Saitama, Japan.
[Tanaka, Kohichi] Tokyo Med & Dent Univ, Ctr Brain Integrat Res, Tokyo 1138510, Japan.
RP Tanaka, K (reprint author), Tokyo Med & Dent Univ, Med Res Inst, Lab Mol Neurosci, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan.
EM tanaka.aud@mri.tmd.ac.jp
RI ahmed, Jamila/E-8653-2015
FU Strategic Research Program for Brain Sciences (SRPBS) from the Ministry
of Education, Culture, Sports, Science and Technology of Japan (MEXT);
MEXT [22700328]; Moritani Scholarship Foundation; Medical Research
Institute (MRI), of TMDU; MRI of TMDU
FX This work was supported by the Strategic Research Program for Brain
Sciences (SRPBS) from the Ministry of Education, Culture, Sports,
Science and Technology of Japan (MEXT, to KT and MK). Additional support
was provided by a Grant-in-Aid for Science Research (22700328 to TA)
from MEXT, grants to TA from The Moritani Scholarship Foundation, a
grant to JY from the Medical Research Institute (MRI), of TMDU, and the
Joint Usage/Research Program of the MRI of TMDU to KFT. The authors
declare no conflict of interest.
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NR 46
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD JUN
PY 2015
VL 40
IS 7
BP 1569
EP 1579
DI 10.1038/npp.2015.26
PG 11
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CH8YC
UT WOS:000354321600002
PM 25662838
ER
PT J
AU Lukas, M
Wohr, M
AF Lukas, Michael
Woehr, Markus
TI Endogenous vasopressin, innate anxiety, and the emission of pro-social
50-kHz ultrasonic vocalizations during social play behavior in juvenile
rats
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Rough-and-tumble Play; Play Fighting; Affitiative Behavior;
Communication; V1a receptor; Autism
ID TRAIT ANXIETY; INTERMALE AGGRESSION; NEURONAL ACTIVATION;
RATTUS-NORVEGICUS; NUCLEUS-ACCUMBENS; INFANT RAT; BRAIN; RECEPTOR;
OXYTOCIN; COMMUNICATION
AB Although the involvement of the neuropeptide arginine vasopressin (AVP) in rodent social interaction is already extensively characterized, little is known about its role in social communication. Rats communicate in the ultrasonic range by means of ultrasonic vocalizations (USV). Depending on developmental stage and affective state, rats emit various distinct types of USV, with appetitive 50-kHz USV being induced by positive social interactions, like juvenile social play, probably serving an affiliative communicative function, namely to (re)establish or induce social proximity. In rats and mice selectively bred for low (LAB) and high (HAB) anxietyrelated behavior, the emission of isolation-induced distress USV during maternal deprivation as pups correlates with innate high levels of hypothalamic AVP availability. Moreover, male LAB and HAB rats express deficits in social approach towards conspecifics, together with high and/or abnormal forms of aggression when confronted with harmless opponents, possibly due to a lack of social communication skills. The aim of this study was therefore (1) to investigate and characterize social play behavior and concomitant pro-social 50-kHz USV emission in male and female, juvenile LAB and HAB rats and to compare them to non-selected Wistar (NAB) rats; and (2) to link these findings pharmacologically to the central AVP system via applying an AVP la receptor (V1aR) antagonist (0.75 mu g; Manning compound) or synthetic AVP (1 ng) into the lateral ventricle of male juvenile NAB rats. Our results show that reduced social play behavior in highly anxious male and female, juvenile HAB rats is accompanied by low amounts of pro-social 50-kHzUSV, as compared to respective LAB and NAB rats, possibly reflecting a lack of positive affective states in expectation of or following social interactions in these individuals. Secondly, although synthetic AVP did not alter social play behavior and pro-social 50-kHz USV, we demonstrated for the first time that a blockade of the central AVP system not only reduces juvenile social play behavior, but at the same time pro-social 50-kHz USV emission rates, indicating an involvement of the social neuropeptide in regulating affiliative communication in rodents. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Lukas, Michael] Univ Regensburg, Fac Biol, Behav & Mol Neurobiol, D-93053 Regensburg, Germany.
[Woehr, Markus] Univ Marburg, Fac Psychol, Behav Neurosci, D-35032 Marburg, Germany.
RP Lukas, M (reprint author), Univ Regensburg, Fac Biol, Behav & Mol Neurobiol, Univ Str 31, D-93053 Regensburg, Germany.
EM Michael.Lukas@ur.de; woehrm@staff.uni-marburg.de
FU German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) [WO
1732/1-1]
FX This work was supported in part by a grant from the German Research
Foundation to MW (Deutsche Forschungsgemeinschaft, DFG; WO 1732/1-1).
Resources had no further role in study design, in the collection,
analysis, and interpretation of data, in the writing of the report, and
in the decision to submit the manuscript for publication.
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NR 54
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2015
VL 56
BP 35
EP 44
DI 10.1016/j.psyneuen.2015.03.005
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CH6JE
UT WOS:000354142100005
PM 25800147
ER
PT J
AU Magnotti, JF
Beauchamp, MS
AF Magnotti, John F.
Beauchamp, Michael S.
TI The noisy encoding of disparity model of the McGurk effect
SO PSYCHONOMIC BULLETIN & REVIEW
LA English
DT Article
DE McGurk effect; Individual differences; Speech perception; Multisensory
integration
ID AUTISM SPECTRUM DISORDERS; SPEECH-PERCEPTION; AUDIOVISUAL INTEGRATION;
CHILDREN; COMBINATION; ILLUSIONS; BINDING; VOICES; FUSION; BRAIN
AB In the McGurk effect, incongruent auditory and visual syllables are perceived as a third, completely different syllable. This striking illusion has become a popular assay of multisensory integration for individuals and clinical populations. However, there is enormous variability in how often the illusion is evoked by different stimuli and how often the illusion is perceived by different individuals. Most studies of the McGurk effect have used only one stimulus, making it impossible to separate stimulus and individual differences. We created a probabilistic model to separately estimate stimulus and individual differences in behavioral data from 165 individuals viewing up to 14 different McGurk stimuli. The noisy encoding of disparity (NED) model characterizes stimuli by their audiovisual disparity and characterizes individuals by how noisily they encode the stimulus disparity and by their disparity threshold for perceiving the illusion. The model accurately described perception of the McGurk effect in our sample, suggesting that differences between individuals are stable across stimulus differences. The most important benefit of the NED model is that it provides a method to compare multisensory integration across individuals and groups without the confound of stimulus differences. An added benefit is the ability to predict frequency of the McGurk effect for stimuli never before seen by an individual.
C1 [Magnotti, John F.; Beauchamp, Michael S.] Univ Texas Houston, Med Sch Houston, Dept Neurobiol & Anat, Houston, TX 77030 USA.
RP Magnotti, JF (reprint author), Univ Texas Houston, Med Sch Houston, Dept Neurobiol & Anat, 6431 Fannin St,Suite G550, Houston, TX 77030 USA.
EM john.magnotti@gmail.com; michael.s.beauchamp@gmail.com
FU NIH [R01NS065395]
FX This research was supported by NIH R01NS065395 to MSB. We thank Wei Ji
Ma and xaq pitkow for helpful comments.
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NR 36
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1069-9384
EI 1531-5320
J9 PSYCHON B REV
JI Psychon. Bull. Rev.
PD JUN
PY 2015
VL 22
IS 3
BP 701
EP 709
DI 10.3758/s13423-014-0722-2
PG 9
WC Psychology, Mathematical; Psychology, Experimental
SC Psychology
GA CH7FA
UT WOS:000354199800009
PM 25245268
ER
PT J
AU Santiesteban, I
Shah, P
White, S
Bird, G
Heyes, C
AF Santiesteban, Idalmis
Shah, Punit
White, Sarah
Bird, Geoffrey
Heyes, Cecilia
TI Mentalizing or submentalizing in a communication task? Evidence from
autism and a camera control
SO PSYCHONOMIC BULLETIN & REVIEW
LA English
DT Article
DE Perspective-taking; Mentalizing; Submentalizing; Object-centered spatial
coding; Director task; Autism
ID HIGH-FUNCTIONING AUTISM; PERSPECTIVE-TAKING; MIND; SPECTRUM; ADULTS
AB In the director task (DT), participants are instructed to move objects within a grid of shelves while ignoring those objects that cannot be seen by a human figure, the "director," located beyond the shelves. It is widely assumed that, since they are explicitly instructed to do, participants use mentalizing in this communicative task; they represent what the director can see, and therefore the DT provides important information about how and when mentalizing is used in adult life. We tested this view against a "submentalizing" hypothesis suggesting that DT performance depends on object-centered spatial coding, without mentalizing. As predicted by the submentalizing account, we found that DT performance was unchanged when the director was replaced by an inanimate object, a camera, and that participants with autism spectrum disorders were unimpaired, relative to matched control participants, in both the director and camera conditions. In combination with recent critical analyses of "implicit mentalizing," these findings support the view that adults use mentalizing sparingly in psychological experiments and in everyday life.
C1 [Santiesteban, Idalmis; Shah, Punit] Univ London, Dept Psychol Sci, London WC1E 7HX, England.
[Shah, Punit; Bird, Geoffrey] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
[White, Sarah; Bird, Geoffrey] UCL, Inst Cognit Neurosci, London WC1N 3AR, England.
[Heyes, Cecilia] Univ Oxford, All Souls Coll, Oxford OX1 4AL, England.
RP Santiesteban, I (reprint author), Univ London, Dept Psychol Sci, Malet St, London WC1E 7HX, England.
EM i.santiesteban@bbk.ac.uk
FU Economic and Social Research Council [ES/H013504/1]
FX The authors thank Iroise Dumontheil for providing helpful feedback on an
earlier version of the manuscript. This work was supported by an
Economic and Social Research Council studentship [ES/H013504/1] awarded
to I.S.
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NR 23
TC 1
Z9 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1069-9384
EI 1531-5320
J9 PSYCHON B REV
JI Psychon. Bull. Rev.
PD JUN
PY 2015
VL 22
IS 3
BP 844
EP 849
DI 10.3758/s13423-014-0716-0
PG 6
WC Psychology, Mathematical; Psychology, Experimental
SC Psychology
GA CH7FA
UT WOS:000354199800027
PM 25149442
ER
PT J
AU Al-Amin, MM
Rahman, MM
Khan, FR
Zaman, F
Reza, HM
AF Al-Amin, Md. Mamun
Rahman, Md. Mahbubur
Khan, Fazlur Rahman
Zaman, Fahmida
Reza, Hasan Mahmud
TI Astaxanthin improves behavioral disorder and oxidative stress in
prenatal valproic acid-induced mice model of autism
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Astaxanthin; Valproic acid; Autism; Oxidative stress
ID SPECTRUM DISORDERS; LIPID-PEROXIDATION; CEREBRAL-ISCHEMIA; SODIUM
VALPROATE; INBRED STRAINS; ANIMAL-MODELS; ADULT RATS; EXPOSURE; BRAIN;
MARKERS
AB Prenatal exposure to valproic acid on gestational day 12.5 may lead to the impaired behavior in the offspring, which is similar to the human autistic symptoms. To the contrary, astaxanthin shows neuroprotective effect by its antioxidant mechanism. We aimed to (i) develop mice model of autism and (ii) investigate the effect of astaxanthin on such model animals.
Valproic acid (600 mg/kg) was administered intraperitoneally to the pregnant mice on gestational day 12.5. Prenatal valproic acid-exposed mice were divided into 2 groups on postnatal day 25 and astaxanthin (2 mg/kg) was given to the experimental group (VPA_AST, n = 10) while saline was given to the control group (VPA, n = 10) for 4 weeks. Behavioral test including social interaction, open field and hot-plate were conducted on postnatal day 25 and oxidative stress markers such as lipid peroxidation, advanced protein oxidation product, nitric oxide, glutathione, and activity of superoxide dismutase and catalase were estimated on postnatal day 26 to confirm mice model of autism and on postnatal day 56 to assess the effect of astaxanthin.
On postnatal day 25, prenatal valproic acid-exposed mice exhibited (i) delayed eye opening (ii) longer latency to respond painful stimuli, (iii) poor sociability and social novelty and (iv) high level of anxiety. In addition, an increased level of oxidative stress was found by determining different oxidative stress markers. Treatment with astaxanthin significantly (p<0.05) improved the behavioral disorder and reduced the oxidative stress in brain and liver.
In conclusion, prenatal exposure to valproic day in pregnant mice leads to the development of autismlike features. Astaxanthin improves the impaired behavior in animal model of autism presumably by its antioxidant activity. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Al-Amin, Md. Mamun; Rahman, Md. Mahbubur; Khan, Fazlur Rahman; Zaman, Fahmida; Reza, Hasan Mahmud] North South Univ, Dept Pharmaceut Sci, Dhaka 1229, Bangladesh.
RP Reza, HM (reprint author), Plot 15,Block B, Dhaka 1229, Bangladesh.
EM reza@northsouth.edu
RI ahmed, Jamila/E-8653-2015
FU North South University [NSU/RGA/022013]
FX There are no conflicts of interest. This work was partially supported by
the research grant provided by the North South University
(NSU/RGA/022013). HMR was a recipient of such grant.
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NR 62
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUN 1
PY 2015
VL 286
BP 112
EP 121
DI 10.1016/j.bbr.2015.02.041
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CG8XS
UT WOS:000353599600018
PM 25732953
ER
PT J
AU Thinnes, FP
AF Thinnes, Friedrich P.
TI Phosphorylation, nitrosation and plasminogen K3 modulation make VDAC-1
lucid as part of the extrinsic apoptotic pathway-Resulting thesis:
Native VDAC-1 indispensible for finalisation of its 3D structure
SO BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
LA English
DT Review
DE Porin; VRAC; Cystic fibrosis; Alzheimers disease; Autism; Malaria
ID DEPENDENT ANION CHANNEL; HUMAN B-LYMPHOCYTES; MITOCHONDRIAL
OUTER-MEMBRANE; PEPTIDE-SPECIFIC ANTIBODIES; HUMAN PORIN; TYPE-1 VDAC;
PLASMA-MEMBRANE; VERTEBRATE PORIN; SKELETAL-MUSCLE; CYSTIC-FIBROSIS
AB Native and recombinant VDAC preparations differ in their acetylation, phosphorylation and nitrosation state; additionally, proteineous modulators are missing in the latter. They thus vary in channel characteristics, as can be taken from comparative black lipid bilayer experiments. Furthermore, the multi-compartment expression makes expect even differing native VDAC-1 molecules.
Recent structural work on mammalian VDAC-1 has only used recombinant material, refolded from Escherichia coli inclusion bodies. While this approach established the basic three-dimensional structure of VDAC-1, a ss-barrel set up by nineteen ss-pleated sheets, dissent is on positioning and movements of its free N-terminal helical peptide stretch preceding E-pleated sheet-1. A synopsis of data concerning posttranslational modifications, cytotopology and physiology of native VDAC-1, from my point of view, suggests that the finalisation of its three-dimensional structure will need native channel preparations to be studied.
Concerning relevance, recent evidence on the regulation of cell membrane-integrated VDAC-1 by posttranslational modifications and proteineous modulators, taken together with experimental demonstrations that VDAC-1 is involved in cell volume regulation, it thus may be part of the extrinsic apoptotic pathway can hopefully help to understand some relevant medical syndromes, e.g. cystic fibrosis, Alzheimer's disease, autism and malaria. (C) 2015 Elsevier B.V. All rights reserved.
EM futhin@t-online.de
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NR 60
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0005-2736
EI 0006-3002
J9 BBA-BIOMEMBRANES
JI Biochim. Biophys. Acta-Biomembr.
PD JUN
PY 2015
VL 1848
IS 6
BP 1410
EP 1416
DI 10.1016/j.bbamem.2015.02.031
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA CH0YE
UT WOS:000353747500016
ER
PT J
AU Feuerriegel, D
Churches, O
Hofmann, J
Keage, HAD
AF Feuerriegel, Daniel
Churches, Owen
Hofmann, Jessica
Keage, Hannah A. D.
TI The N170 and face perception in psychiatric and neurological disorders:
A systematic review
SO CLINICAL NEUROPHYSIOLOGY
LA English
DT Review
DE N170; VPP; M170; Systematic review; Event-related potentials; Face
perception
ID EVENT-RELATED POTENTIALS; AUTISM SPECTRUM DISORDER; EMOTIONAL FACIAL
EXPRESSIONS; AFFECT RECOGNITION DEFICITS; BRAIN POTENTIALS; BIPOLAR
DISORDER; PARKINSONS-DISEASE; SOCIAL PHOBIA; ERP EVIDENCE;
NEUROPHYSIOLOGICAL RESPONSES
AB Objective: To systematically evaluate evidence for configural and affective face processing abnormalities as measured by the N170 and Vertex Positive Potential (VPP) event-related potential components, and analogous M170 magnetoencephalography (MEG) component, in neurological and psychiatric disorders.
Methods: 1251 unique articles were identified using PsychINFO and PubMed databases. Sixty-seven studies were selected for review, which employed various tasks to measure the N170, M170 or VPP; the 13 neurological/psychiatric conditions were Attention-Deficit Hyperactivity Disorder (ADHD), Alcohol Dependence, Alzheimer's Disease, Autism Spectrum Disorders (ASDs), Bipolar Disorder, Bulimia Nervosa, Fibromyalgia, Huntington's Disease, Major Depressive Disorder, Parkinson's Disease, Prosopagnosia, Schizophrenia and Social Phobia.
Results: Smaller N170 and VPP amplitudes to faces compared to healthy controls were consistently reported in Schizophrenia but not in ASDs. In Schizophrenia N170 and VPP measures were not correlated with clinical symptoms. Findings from other disorders were highly inconsistent; however, reported group differences were almost always smaller amplitudes or slower latencies to emotional faces in disordered groups regardless of diagnosis.
Conclusions: Results suggest that N170/VPP abnormalities index non-specific facial affect processing dysfunction in these neurological and psychiatric conditions, reflecting social impairments being broadly characteristic of these groups.
Significance: The N170 and analogous components hold promise as diagnostic and treatment monitoring biomarkers for social dysfunction. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Feuerriegel, Daniel; Hofmann, Jessica; Keage, Hannah A. D.] Univ S Australia, Cognit Neurosci Lab, Adelaide, SA 5001, Australia.
[Churches, Owen] Flinders Univ S Australia, Brain & Cognit Lab, Adelaide, SA 5001, Australia.
RP Feuerriegel, D (reprint author), Univ S Australia, Sch Psychol Social Work & Social Policy, Cognit Neurosci Lab, St Bernards Rd, Adelaide, SA 5001, Australia.
EM Daniel.Feuerriegel@Unisa.edu.au
FU Australian National Health and Medical Research Council Training Award
[568890]
FX H.A.D.K. was supported by an Australian National Health and Medical
Research Council Training Award (568890). We thank Dr Mark Kohler for
his support within the UniSA Cognitive Neuroscience Laboratory.
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NR 125
TC 0
Z9 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 1388-2457
EI 1872-8952
J9 CLIN NEUROPHYSIOL
JI Clin. Neurophysiol.
PD JUN
PY 2015
VL 126
IS 6
BP 1141
EP 1158
DI 10.1016/j.clinph.2014.09.015
PG 18
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CH1ME
UT WOS:000353785000011
PM 25306210
ER
PT J
AU Ricketts, J
Dockrell, JE
Patel, N
Charman, T
Lindsay, G
AF Ricketts, Jessie
Dockrell, Julie E.
Patel, Nita
Charman, Tony
Lindsay, Geoff
TI Do children with specific language impairment and autism spectrum
disorders benefit from the presence of orthography when learning new
spoken words?
SO JOURNAL OF EXPERIMENTAL CHILD PSYCHOLOGY
LA English
DT Article
DE Specific language impairment; Autism spectrum disorders; Word learning;
Vocabulary; Vocabulary acquisition; Orthographic facilitation;
Orthography
ID READING-COMPREHENSION; BEGINNING READERS; MNEMONIC VALUE; SIMPLE VIEW;
ACQUISITION; CONSISTENCY; DISABILITY; HYPOTHESIS; KNOWLEDGE; MEANINGS
AB This experiment investigated whether children with specific language impairment (SLI), children with autism spectrum disorders (ASD), and typically developing children benefit from the incidental presence of orthography when learning new oral vocabulary items. Children with SLI, children with ASD, and typically developing children (n = 27 per group) between 8 and 13 years of age were matched in triplets for age and nonverbal reasoning. Participants were taught 12 mappings between novel phonological strings and referents; half of these mappings were trained with orthography present and half were trained with orthography absent. Groups did not differ on the ability to learn new oral vocabulary, although there was some indication that children with ASD were slower than controls to identify newly learned items. During training, the ASD, SLI, and typically developing groups benefited from orthography to the same extent. In supplementary analyses, children with SLI were matched in pairs to an additional control group of younger typically developing children for nonword reading. Compared with younger controls, children with SLI showed equivalent oral vocabulary acquisition and benefit from orthography during training. Our findings are consistent with current theoretical accounts of how lexical entries are acquired and replicate previous studies that have shown orthographic facilitation for vocabulary acquisition in typically developing children and children with ASD. We demonstrate this effect in SLI for the first time. The study provides evidence that the presence of orthographic cues can support oral vocabulary acquisition, motivating intervention approaches (as well as standard classroom teaching) that emphasize the orthographic form. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Ricketts, Jessie] Univ London, Dept Psychol, Royal Holloway, Egham TW20 0EX, Surrey, England.
[Dockrell, Julie E.] UCL, UCL Inst Educ, London WC1H 0AL, England.
[Patel, Nita] City Univ London, Div Language & Commun Sci, London EC1V 0HB, England.
[Charman, Tony] Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England.
[Lindsay, Geoff] Univ Warwick, Ctr Educ Dev Appraisal & Res, Coventry CV4 7AL, W Midlands, England.
RP Ricketts, J (reprint author), Univ London, Dept Psychol, Royal Holloway, Egham TW20 0EX, Surrey, England.
EM jessie.ricketts@rhul.ac.uk
FU UK Department for Education as part of the Better Communication Research
Programme
FX We acknowledge the support of all the students, their families, and
their schools. We are also grateful to Olympia Palikara and Mia Travlos
for assistance with data collection. This research was funded by the UK
Department for Education as part of the Better Communication Research
Programme
(https://www.gov.uk/governmentiorganisationsidepartment-for-education/se
ries/better-communication-research-programme, accessed 28 August 2014).
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NR 63
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-0965
EI 1096-0457
J9 J EXP CHILD PSYCHOL
JI J. Exp. Child Psychol.
PD JUN
PY 2015
VL 134
BP 43
EP 61
DI 10.1016/j.jecp.2015.01.015
PG 19
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA CH0SZ
UT WOS:000353734000004
PM 25795987
ER
PT J
AU Perez-Gonzalez, LA
Diaz, E
Fernandez-Garcia, S
Baizan, C
AF Antonio Perez-Gonzalez, Luis
Diaz, Elvira
Fernandez-Garcia, Silvia
Baizan, Cristina
TI Stimuli with identical contextual functions taught independently become
functionally equivalent
SO LEARNING & BEHAVIOR
LA English
DT Article
DE Contextual control; Stimulus relations; Stimulus equivalence;
Associative learning; Functional equivalence; Language; Verbal behavior
ID 2ND-ORDER CONDITIONAL DISCRIMINATIONS; LEARNING-SET; CHILDREN; SAMPLE;
REINFORCEMENT; EXPANSION; PIGEONS; ADULTS
AB A novel learning process that does not require stimulus associations was explored in humans. The hypothesis was that two contextual stimuli taught in separate settings, with different stimuli, become equivalent if they accomplish identical functions with regard to the relations between the stimuli presented with them. The procedure consisted of : (a) first teaching an AB conditional discrimination (e.g., match A1 to B1 and A2 to B2) and then teaching a second-order XAB conditional discrimination in which X1 indicated performing the same selections as in AB and X2 indicated selecting the alternative comparison (e.g., match A1 to B2 and A2 to B1); (b) repeating the procedure with completely new stimuli, YHJ, in which the functions of the Y stimuli were identical to those of X; and (c) conducting a final probe under extinction to verify the equivalence between the X and the Y stimuli. Three experiments were conducted to explore the process and to rule out the influence of alternative variables. Out of these, 13 of the 14 participants matched the stimuli to the same contextual functions. Thus, the hypothesis was verified. These results demonstrate that humans are able to match stimuli according to their functions in relation to other stimuli. This process may be very much involved in language; for example, understanding that words or clauses that have been learned in separate contexts and with separate stimuli share the same meaning. Understanding this process may help to identify learning or developmental problems, such as those shown by persons with autism, and help to treat them.
C1 [Antonio Perez-Gonzalez, Luis] Univ Oviedo, Dept Psychol, Oviedo 33003, Spain.
[Diaz, Elvira; Fernandez-Garcia, Silvia; Baizan, Cristina] Univ Oviedo, Sch Psychol, Oviedo 33003, Spain.
RP Perez-Gonzalez, LA (reprint author), Univ Oviedo, Dept Psychol, Plaza Feijoo S-N,Despacho 209, Oviedo 33003, Spain.
EM laperez@uniovi.es
FU Ministerio de Ciencia e Innovacion, Spain [PSI2009-08644]
FX This research was supported by grant PSI2009-08644 from the Ministerio
de Ciencia e Innovacion, Spain, to the first author, who directed the
study. The other three authors contributed approximately equally. The
authors thank two anonymous reviewers of previous versions of the
manuscript, and Jeanne Speakman for editing the manuscript.
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NR 30
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1543-4494
EI 1543-4508
J9 LEARN BEHAV
JI Learn Behav.
PD JUN
PY 2015
VL 43
IS 2
BP 113
EP 128
DI 10.3758/s13420-014-0166-6
PG 16
WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental;
Zoology
SC Psychology; Behavioral Sciences; Zoology
GA CH1WZ
UT WOS:000353814600002
PM 25673100
ER
PT J
AU Gupta, SC
Yadav, R
Pavuluri, R
Morley, BJ
Stairs, DJ
Dravid, SM
AF Gupta, Subhash C.
Yadav, Roopali
Pavuluri, Ratnamala
Morley, Barbara J.
Stairs, Dustin J.
Dravid, Shashank M.
TI Essential role of GluD1 in dendritic spine development and GluN2B to
GluN2A NMDAR subunit switch in the cortex and hippocampus reveals
ability of GluN2B inhibition in correcting hyperconnectivity
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Glutamate; Dendritic spine; GRID1; GluD1; GluN2B
ID CANDIDATE GENES; PRESYNAPTIC DIFFERENTIATION; PREFRONTAL CORTEX; SYNAPSE
FORMATION; LIM-KINASE; RECEPTOR; AUTISM; PLASTICITY; COFILIN; NEURONS
AB The glutamate delta-1 (GluD1) receptor is highly expressed in the forebrain. We have previously shown that loss of GluD1 leads to social and cognitive deficits in mice, however, its role in synaptic development and neurotransmission remains poorly understood. Here we report that GluD1 is enriched in the medial prefrontal cortex (mPFC) and GluD1 knockout mice exhibit a higher dendritic spine number, greater excitatory neurotransmission as well as higher number of synapses in mPFC. In addition abnormalities in the LIMK1-cofilin signaling, which regulates spine dynamics, and a lower ratio of GluN2A/GluN2B expression was observed in the mPFC in GluD1 knockout mice. Analysis of the GluD1 knockout CA1 hippocampus similarly indicated the presence of higher spine number and synapses and altered LIMK1-cofilin signaling. We found that systemic administration of an N-methyl-D-aspartate (NMDA) receptor partial agonist D-cycloserine (DCS) at a high-dose, but not at a low-dose, and a GluN2B-selective inhibitor Ro-25-6981 partially normalized the abnormalities in LIMK1-cofilin signaling and reduced excess spine number in mPFC and hippocampus. The molecular effects of high-dose DCS and GluN2B inhibitor correlated with their ability to reduce the higher stereotyped behavior and depression-like behavior in GluD1 knockout mice. Together these findings demonstrate a critical requirement for GluD1 in normal spine development in the cortex and hippocampus. Moreover, these results identify inhibition of GluN2B-containing receptors as a mechanism for reducing excess dendritic spines and stereotyped behavior which may have therapeutic value in certain neurodevelopmental disorders such as autism. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Gupta, Subhash C.; Yadav, Roopali; Pavuluri, Ratnamala; Dravid, Shashank M.] Creighton Univ, Dept Pharmacol, Omaha, NE 68178 USA.
[Stairs, Dustin J.] Creighton Univ, Dept Psychol, Omaha, NE 68178 USA.
[Morley, Barbara J.] Boys Town Natl Res Hosp, Neurochem Lab, Omaha, NE 68178 USA.
RP Dravid, SM (reprint author), Creighton Univ, Sch Med, Dept Pharmacol, 2500 Calif Plaza, Omaha, NE 68178 USA.
EM ShashankDravid@creighton.edu
FU Health Future Foundation; Faculty Development Award [LB692]; EPSCoR
Award; National Institute of Health (NIH) [1R21MH098270]; NE DHHS
[2014-08]; National Center for Research Resources [G20RR024001]
FX This work was supported by Health Future Foundation (SMD), LB692 Faculty
Development Award (SMD), EPSCoR Award (SMD, BJM), National Institute of
Health (NIH) #1R21MH098270 (SMD) and a grant from NE DHHS (Stem Cell
2014-08). The project was also supported by G20RR024001 from National
Center for Research Resources. The content is solely the responsibility
of the authors and does not necessarily represent the official views of
the National Center for Research Resources or the National Institutes of
Health. We thank Dr. Suneet Mehrotra and Dr. Thomas F. Murray for
providing technical support and resources for Gene Gun and Imaris
analysis.
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NR 60
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
EI 1873-7064
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD JUN
PY 2015
VL 93
BP 274
EP 284
DI 10.1016/j.neuropharm.2015.02.013
PG 11
WC Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA CH0RK
UT WOS:000353729900028
PM 25721396
ER
PT J
AU Mitchell, DB
Hauser-Cram, P
Crossman, MK
AF Mitchell, D. B.
Hauser-Cram, P.
Crossman, M. K.
TI Relationship dimensions of the 'Down syndrome advantage'
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE behavioural phenotypes; Down syndrome; intellectual disability; parents
ID YOUNG-CHILDREN; PRESCHOOL-CHILDREN; BEHAVIOR PROBLEMS; PARENTING STRESS;
SYNDROME SPECIFICITY; INTELLECTUAL DISABILITY; MATERNAL DIRECTIVENESS;
DEVELOPMENTAL DELAY; MOTHERS; AUTISM
AB BackgroundSome researchers have proposed an advantage' for parents of children with Down syndrome over parents of children with other intellectual disabilities, especially in relation to experiencing less parenting stress. Others have maintained that these differences are an artefact of demographic and related differences. This study extends the investigation of possible differences in dimensions of parenting stress and also examines whether differences exist in maternal and child contingent responsiveness during mother-child interaction in these two groups.
MethodMothers of children with Down syndrome (n=43) and undifferentiated developmental disabilities (n=54) completed measures of children's adaptive functioning and behaviour problems, parenting stress and maternal social support. Observers rated the contingent interactions between mothers and children using the Nursing Child Assessment Teaching Scale.
ResultsOnce mother's age, education and social support as well as child adaptive functioning and behaviour problems were considered, neither parent nor child related parenting stress demonstrated an advantage for parents of children with Down syndrome. However, a Down syndrome advantage' was apparent for both maternal and child contingent responsiveness after accounting for maternal demographic and contextual variables and child attributes.
ConclusionsChildren with Down syndrome and their mothers have more positive interactions than children with other developmental disabilities, both in terms of the responsiveness of mothers and of child responses contingent on maternal behaviour. These findings suggest that both children with Down syndrome themselves and their mothers are contributing to a Down syndrome advantage.
C1 [Mitchell, D. B.] Colby Sawyer Coll, Social Sci & Educ, New London, NH 03257 USA.
[Hauser-Cram, P.] Boston Coll, Counseling Dev & Educ Psychol Dept, Chestnut Hill, MA 02167 USA.
[Crossman, M. K.] Brandeis Univ, Lurie Inst Disabil Policy, Heller Sch Social Policy & Management, Waltham, MA USA.
[Crossman, M. K.] Boston Children Hosp, Boston, MA USA.
RP Mitchell, DB (reprint author), Colby Sawyer Coll, Social Sci & Educ, 541 Main St,Colgate 309, New London, NH 03257 USA.
EM darcy.b.mitchell@colby-sawyer.edu
FU U.S. Department of Health and Human Services, Health Resources and
Services Administration, Maternal and Child Health Research Program [R40
MC08956]; NIMH/NIH [R25 MH071286]; LEND grant, Maternal Child and Health
Bureau [T73MH00020]
FX The Early Intervention Collaborative Study (EICS) is funded by Grant No.
R40 MC08956 through the U.S. Department of Health and Human Services,
Health Resources and Services Administration, Maternal and Child Health
Research Program. Additional partial support for manuscript preparation
was provided by NIMH/NIH R25 MH071286 and LEND grant T73MH00020,
Maternal Child and Health Bureau. This study was approved by the
Institutional Review Board at Boston College, 140 Commonwealth Avenue,
Chestnut Hill, MA 02467. We wish to thank the many children and families
who have participated in this investigation.
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NR 64
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD JUN
PY 2015
VL 59
IS 6
BP 506
EP 518
DI 10.1111/jir.12153
PG 13
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA CG4GG
UT WOS:000353242900002
PM 25070618
ER
PT J
AU Minnes, P
Perry, A
Weiss, JA
AF Minnes, P.
Perry, A.
Weiss, J. A.
TI Predictors of distress and well-being in parents of young children with
developmental delays and disabilities: the importance of parent
perceptions
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE coping; developmental disability; parent stress; young children
ID INTELLECTUAL DISABILITY; PRESCHOOL-CHILDREN; BEHAVIOR PROBLEMS; POSITIVE
PERCEPTIONS; FAMILY IMPACT; SELF-EFFICACY; MENTAL-HEALTH; MOTHERS;
EMPOWERMENT; AUTISM
AB BackgroundMoving from family-centred to child-centred models of service delivery can be stressful for parents as their young children with developmental delays and disabilities transition into school. The purpose of this paper was to explore and compare predictors of both distress and well-being in parents during this transition period.
MethodsA sample of 155 mothers of 113 boys and 42 girls participated in the study. The mean age of the children was 4.9 years and their diagnoses included autism spectrum disorder (52%); unspecified intellectual disability/developmental delay (26%); Down syndrome (12%); other genetic conditions (4%) and other diagnoses (6%). Participants completed surveys primarily online focusing on child characteristics, family resources, parent coping strategies, parental distress and positive gain.
ResultsMultiple regression analyses were conducted to determine predictors of parent reported distress and positive gain. Parent coping variables were the strongest predictors of both positive gain and parental distress, with reframing emerging as a predictor of positive gain and parent empowerment emerging as a predictor of both greater positive gain and lower parental distress.
ConclusionsThe results of this study highlight not only the importance of including positive as well as negative outcomes in research with parents but also the importance of including parent characteristics such as coping strategies (e.g. reframing and empowerment/self-efficacy) as potential predictors of outcome in such studies.
C1 [Minnes, P.] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada.
[Perry, A.; Weiss, J. A.] York Univ, Dept Psychol, Toronto, ON M3J 2R7, Canada.
RP Minnes, P (reprint author), Queens Univ, Psychol, 62 Arch St,32 Newcourt Pl, Kingston, ON K7L 3N6, Canada.
EM patricia.minnes@queensu.ca
FU Canadian Institutes for Health Research [94788]
FX This research was funded by the Canadian Institutes for Health Research
(Grant #94788) Data for this study were collected as part of the
Canadian Institutes for Health Research Team HELPS Inc: Health Education
and Learning Partnerships Promoting Social Inclusion of Children with
Developmental Delays and Disabilities. (www.helpsinc.ca)
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NR 52
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD JUN
PY 2015
VL 59
IS 6
BP 551
EP 560
DI 10.1111/jir.12160
PG 10
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA CG4GG
UT WOS:000353242900006
PM 25169777
ER
PT J
AU Griffith, GM
Hastings, RP
Petalas, MA
Lloyd, TJ
AF Griffith, G. M.
Hastings, R. P.
Petalas, M. A.
Lloyd, T. J.
TI Mothers' expressed emotion towards children with autism spectrum
disorder and their siblings
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE ASD; autism; expressed emotion; family; mothers; siblings
ID MENTAL-HEALTH STATUS; FRAGILE-X-SYNDROME; BEHAVIOR PROBLEMS;
INTELLECTUAL DISABILITY; DOWN-SYNDROME; DEVELOPMENTAL DISABILITY;
PSYCHOLOGICAL IMPACT; RELATIONSHIP QUALITY; SYNDROME SPECIFICITY;
PRESCHOOL-CHILDREN
AB BackgroundExpressed emotion (EE) is a construct used to measure the emotional climate within families. EE is of interest to researchers in the field of autism spectrum disorder (ASD) because of its putative implications for child development. The aim was to explore whether maternal EE differs towards a child with ASD and a non-disabled sibling.
MethodsWe adopted a within-family design with 143 mothers of children with ASD and a non-disabled sibling. EE was measured using the Five-Minute Speech Sample.
ResultsWilcoxon signed-rank tests were utilised. Mothers were coded as significantly more critical and less warm towards their child with ASD than towards the sibling. There were no significant differences in maternal emotional overinvolvement or overall EE towards the child with ASD and a sibling.
ConclusionsThe data support the results of previous research suggesting that EE is linked to the relationship a mother has with individual children, rather than being evidence of the character disposition of mothers. More research is needed to understand the emotional dimensions of parent-child relationships in families with children with ASD.
C1 [Griffith, G. M.; Lloyd, T. J.] Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
[Hastings, R. P.] Univ Warwick, CEDAR, Warwick, England.
[Petalas, M. A.] Mental Healthcare UK Ltd, Llangwyfan, Denbigh, England.
RP Griffith, GM (reprint author), Bangor Univ, Psychol, Briganita Bldg,Penrhalt Rd, Bangor LL57 2AS, Gwynedd, Wales.
EM g.m.griffith@bangor.ac.uk
FU Bangor University; National Autistic Society Cymru; European Social Fund
FX This research was supported in part by funding from Bangor University,
the National Autistic Society Cymru and the European Social Fund,
objective 1 area funding. No conflict of interest is declared.
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NR 41
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD JUN
PY 2015
VL 59
IS 6
BP 580
EP 587
DI 10.1111/jir.12178
PG 8
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA CG4GG
UT WOS:000353242900009
PM 25521064
ER
PT J
AU Omori, M
Yamamoto, J
AF Omori, Mikimasa
Yamamoto, Jun-ichi
TI Spelling Instruction by Stimulus Pairing in Japanese Students with
Autism Spectrum Disorders: Effects of Stimulus Presentation Order
SO PSYCHOLOGICAL RECORD
LA English
DT Article
DE Stimulus pairing procedure; Stimulus relations; Spelling; Autism
spectrum disorders
ID EQUIVALENCE-RELATIONS; TO-SAMPLE; DISABILITIES; CHILDREN;
DISCRIMINATION; INDIVIDUALS; FAMILIARITY; ATTENTION; SKILLS; SELF
AB Students with autism spectrum disorder (ASD) often have difficulties in learning stimulus relations in spelling. Using the two-stimulus pairing procedure, we examined the emergence of stimulus relations between Japanese and English words by comparing the spelling performance of five students with ASD with that of five typically developing students. In the Japanese-English pairing procedure, a Japanese word was presented first, followed by its English translation, and in the English-Japanese pairing, an English word was presented first, followed by its Japanese translation. Training effects were evaluated with a sign test and analysis of variance. All the students correctly spelled the English words in both procedures. The Japanese-English pairing procedure required fewer training blocks than the English-Japanese pairing procedure. In the Japanese-English pairing, students with ASD required fewer training blocks than typically developing students. These results suggest that presenting already established words (i.e., Japanese) first might better facilitate the emergence of stimulus relations in a stimulus pairing procedure.
C1 [Omori, Mikimasa] Keio Univ, Dept Psychol, Grad Sch Human Relat, Tokyo 1088345, Japan.
[Omori, Mikimasa] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Dev Disorders, Kodaira, Tokyo 1878553, Japan.
[Omori, Mikimasa] Japan Soc Promot Sci, Chiyoda Ku, Tokyo, Japan.
[Yamamoto, Jun-ichi] Keio Univ, Dept Psychol, Fac Letters, Minato Ku, Tokyo 1088345, Japan.
RP Omori, M (reprint author), Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Dev Disorders, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878553, Japan.
EM mikkiomori@a2.keio.jp
RI ahmed, Jamila/E-8653-2015
FU Japan Society for the Promotion of Science; Research Center for Thinking
and Behavioral Judgment Proceedings at Keio University
FX This research was supported in part by grants from the Japan Society for
the Promotion of Science and the Research Center for Thinking and
Behavioral Judgment Proceedings at Keio University. The Keio University
Institutional Review Board of the Faculty of Letters approved this
study.
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Wolf M., 2005, RAN RAS RAPID AUTOMA
NR 25
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2933
EI 2163-3452
J9 PSYCHOL REC
JI Psychol. Rec.
PD JUN
PY 2015
VL 65
IS 2
BP 401
EP 410
DI 10.1007/s40732-014-0114-z
PG 10
WC Psychology, Multidisciplinary
SC Psychology
GA CG5OL
UT WOS:000353341500015
ER
PT J
AU Casey, AF
Quenneville-Himbeault, G
Normore, A
Davis, H
Martell, SG
AF Casey, Amanda Faith
Quenneville-Himbeault, Gabriel
Normore, Alexa
Davis, Hanna
Martell, Stephen G.
TI A Therapeutic Skating Intervention for Children With Autism Spectrum
Disorder
SO PEDIATRIC PHYSICAL THERAPY
LA English
DT Article
DE activities of daily living; autism spectrum disorder; child; human;
male; motor skills; physical activity; postural balance
ID PHYSICAL-ACTIVITY; DISABILITIES; INDIVIDUALS; EXERCISE
AB Purpose: The purpose of this study was to evaluate the effects of a highly structured therapeutic skating intervention on motor outcomes and functional capacity in 2 boys with autism spectrum disorder aged 7 and 10 years. Methods: This multiple-baseline, single-subject study assigned participants to three 1-hour skating sessions per week for 12 weeks focusing on skill and motor development. Multiple data points assessed (a) fidelity to the intervention and (b) outcomes measures including the Pediatric Balance Scale, Timed Up and Go, floor to stand, Six-Minute Walk Test, goal attainment, and weekly on-ice testing. Results: Improvements were found in balance, motor behavior, and functional capacity by posttest with gains remaining above pretest levels at follow-up. Conclusions: Therapeutic skating may produce physical benefits for children with autism spectrum disorder and offer a viable, inexpensive community-based alternative to other forms of physical activity.
C1 [Casey, Amanda Faith; Quenneville-Himbeault, Gabriel; Normore, Alexa; Davis, Hanna; Martell, Stephen G.] St Francis Xavier Univ, Dept Human Kinet, Antigonish, NS B2G 2R6, Canada.
RP Casey, AF (reprint author), St Francis Xavier Univ, Dept Human Kinet, POB 5000, Antigonish, NS B2G 2R6, Canada.
EM acasey@stfx.ca
CR American College of Sports Medicine, 2000, ACSMS GUID EX TEST P, V6th
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 35
TC 1
Z9 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0898-5669
EI 1538-005X
J9 PEDIATR PHYS THER
JI Pediatr. Phys. Ther.
PD SUM
PY 2015
VL 27
IS 2
BP 170
EP 177
DI 10.1097/PEP.0000000000000139
PG 8
WC Pediatrics; Rehabilitation
SC Pediatrics; Rehabilitation
GA CE8EW
UT WOS:000352075400017
PM 25822357
ER
PT J
AU Bhat, A
Bubela, D
AF Bhat, Anjana
Bubela, Deborah
TI Commentary on "A Therapeutic Skating Intervention for Children With
Autism Spectrum Disorder"
SO PEDIATRIC PHYSICAL THERAPY
LA English
DT Editorial Material
C1 [Bhat, Anjana] Univ Delaware, Phys Therapy Program, Newark, DE 19716 USA.
[Bhat, Anjana; Bubela, Deborah] Univ Connecticut, Phys Therapy Program, Storrs, CT USA.
RP Bhat, A (reprint author), Univ Delaware, Phys Therapy Program, Newark, DE 19716 USA.
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0898-5669
EI 1538-005X
J9 PEDIATR PHYS THER
JI Pediatr. Phys. Ther.
PD SUM
PY 2015
VL 27
IS 2
BP 177
EP 177
DI 10.1097/PEP.0000000000000140
PG 1
WC Pediatrics; Rehabilitation
SC Pediatrics; Rehabilitation
GA CE8EW
UT WOS:000352075400018
PM 25822358
ER
PT J
AU Good, B
Fang, L
AF Good, Bethany
Fang, Lin
TI Promoting Smart and Safe Internet Use Among Children with
Neurodevelopmental Disorders and Their Parents
SO CLINICAL SOCIAL WORK JOURNAL
LA English
DT Article
DE Internet safety; Cyber bullying; Digital literacy; Digital citizenship;
Autism spectrum; Learning disabilities; Mental health; Group therapy;
ADHD
ID AUTISM SPECTRUM DISORDERS; LEARNING-DISABILITIES; MENTAL-HEALTH;
ADOLESCENTS; ONLINE; PREVALENCE; YOUTH; VICTIMIZATION; COMMUNICATION;
ADDICTION
AB Technological devices and the internet have become standard tools used by young people in their social, recreational and educational contexts. The utility of digital technology continues to expand and influence the ways young people socialize, learn about the world and develop and experiment with identity. The ability to remain in one's own home while also connecting with others can be perceived as safer than venturing out in the offline world; however, there are a variety of risks associated with online activities. Some youth may be more at risk of harm than others, such as youth with neurodevelopmental disorders including learning disabilities (LDs), autism spectrum disorder (ASD) and attention deficit hyperactive disorder (ADHD). There is an instinct for adults to be protective of children who struggle with disabilities, leading some parents to take an overprotective approach to their child's internet use. Parents can play a significant role in helping their children navigate the pitfalls associated with online use while enjoying the benefits it provides. In this paper, we discuss the characteristics of young people with neurodevelopmental disorders that may cause difficulties online and review the opportunities and risks associated with internet use. We then discuss ways for parents to provide effective and balanced guidance on internet use for their child by reviewing the literature and offering concepts on digital literacies. The paper ends with a proposed intergenerational, parent-child group intervention that aims to help parents safeguard young people from online harms and offers opportunities for healthy online participation.
C1 [Good, Bethany; Fang, Lin] Univ Toronto, Factor Inwentash Fac Social Work, Toronto, ON M5S 1V4, Canada.
RP Good, B (reprint author), Univ Toronto, Factor Inwentash Fac Social Work, 246 Bloor St West, Toronto, ON M5S 1V4, Canada.
EM bethany.good@mail.utoronto.ca
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American Psychiatric Association, 2013, DIAGN STAT MAN MENT
[Anonymous], 2013, MED LIT FUND
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Zamaria C., 2008, CANADA ONLINE INTERN
NR 72
TC 0
Z9 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0091-1674
EI 1573-3343
J9 CLIN SOC WORK J
JI Clin. Soc. Work J.
PD JUN
PY 2015
VL 43
IS 2
SI SI
BP 179
EP 188
DI 10.1007/s10615-015-0519-4
PG 10
WC Social Work
SC Social Work
GA CE5WG
UT WOS:000351905800008
ER
PT J
AU Crespi, BJ
Hurd, PL
AF Crespi, Bernard J.
Hurd, Peter L.
TI Genetically based correlates of serum oxytocin and testosterone in
autism and schizotypy
SO PERSONALITY AND INDIVIDUAL DIFFERENCES
LA English
DT Article
DE Testosterone; Oxytocin; Autism; Schizotypy; Social cognition
ID INTRANASAL OXYTOCIN; PERSONALITY-DISORDER; ASPERGER-SYNDROME; PLASMA
OXYTOCIN; HORMONE-LEVELS; RECEPTOR GENE; HUMAN BRAIN; SCHIZOPHRENIA;
AMYGDALA; BEHAVIOR
AB The hormones oxytocin and testosterone have been implicated in autism spectrum and schizophrenia-spectrum cognition and disorders, but their roles in mediating these psychological phenotypes remain largely unknown. We genotyped a large set of healthy individuals for loci that represent established genetic indicators of serum testosterone and oxytocin levels, and tested for associations of these genetic indices of hormone levels with self-report measures of autistic and schizotypal cognition. A low genetic index of testosterone, a high genetic index of oxytocin, and/or a low ratio of testosterone to oxytocin indices were positively correlated with high imagination (by the Autism Quotient) and high positive and total schizotypy (by the Schizotypal Personality Questionnaire). The genetic indices for oxytocin, and testosterone relative to oxytocin, also showed significant correlations with a metric of positive schizotypy relative to autism, implicating higher oxytocin and lower testosterone in increased positively-schizotypal traits combined with decreased autism-associated traits. These results link genetic indicators of serum hormone levels with measures of schizotypy and autism among healthy individuals. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Crespi, Bernard J.] Simon Fraser Univ, Dept Biol, Burnaby, BC V5A 1S6, Canada.
[Hurd, Peter L.] Univ Alberta, Dept Psychol, Edmonton, AB T6G 2R3, Canada.
[Hurd, Peter L.] Univ Alberta, Ctr Neurosci, Edmonton, AB T6G 2R3, Canada.
RP Crespi, BJ (reprint author), Simon Fraser Univ, Dept Biol, Burnaby, BC V5A 1S6, Canada.
EM crespi@sfu.ca
FU Natural Science and Engineering Research Council of Canada
FX We are grateful to the Natural Science and Engineering Research Council
of Canada for support, and to the Editor and three anonymous reviewers
for helpful comments.
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NR 49
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0191-8869
J9 PERS INDIV DIFFER
JI Pers. Individ. Differ.
PD JUN
PY 2015
VL 79
BP 39
EP 43
DI 10.1016/j.paid.2015.01.052
PG 5
WC Psychology, Social
SC Psychology
GA CE2OG
UT WOS:000351654300008
ER
PT J
AU Gallitto, E
Leth-Steensen, C
AF Gallitto, Elena
Leth-Steensen, Craig
TI Autistic traits and adult attachment styles
SO PERSONALITY AND INDIVIDUAL DIFFERENCES
LA English
DT Article
DE Autism-Spectrum Quotient; Attachment avoidance; Attachment anxiety;
BIS/BAS; Personality
ID SPECTRUM QUOTIENT AQ; HIGH-FUNCTIONING AUTISM; MENTAL-RETARDATION;
ASPERGER-SYNDROME; SOCIAL DEFICITS; CHILDREN; DISORDER; RESPONSES;
LONELINESS; PHENOTYPE
AB This study examined the relationship between autistic traits and adult attachment styles in a non-clinical sample of 326 university students. Multiple regression analysis was used to predict both attachment avoidance and attachment anxiety from levels of self-reported autistic traits. A significant unique relationship between autistic traits and attachment avoidance was found after controlling for all Big-Five personality traits, BIS/BAS, gender, and current relationship status. Hence, individuals who report more autistic-like behaviours, especially with respect to communication difficulties, are less likely to report sharing high levels of emotional closeness with romantic partners. On the other hand, no unique relationship between autistic traits and attachment anxiety was present. (c) 2015 Elsevier Ltd. All rights reserved.
C1 [Gallitto, Elena] Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada.
[Leth-Steensen, Craig] Carleton Univ, Dept Psychol, Ottawa, ON K1S 5B6, Canada.
RP Gallitto, E (reprint author), Univ Ottawa, Sch Psychol, 136 Jean Jacques Lussier Vanier Hall, Ottawa, ON K1N 6N5, Canada.
EM egall065@uottawa.ca; Craig.LethSteensen@carle-ton.ca
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 42
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0191-8869
J9 PERS INDIV DIFFER
JI Pers. Individ. Differ.
PD JUN
PY 2015
VL 79
BP 63
EP 67
DI 10.1016/j.paid.2015.01.032
PG 5
WC Psychology, Social
SC Psychology
GA CE2OG
UT WOS:000351654300012
ER
PT J
AU Alrahbeni, T
Sartor, F
Anderson, J
Miedzybrodzka, Z
McCaig, C
Muller, B
AF Alrahbeni, Tahani
Sartor, Francesca
Anderson, Jihan
Miedzybrodzka, Zosia
McCaig, Colin
Mueller, Berndt
TI Full UPF3B function is critical for neuronal differentiation of neural
stem cells
SO MOLECULAR BRAIN
LA English
DT Article
DE Autism; Schizophrenia; X-linked intellectual disability;
Nonsense-mediated mRNA decay; UPF3B mutation; UPF1; Tethered function
assay; qPCR; Arhgap24; Atf4; Protein localisation
ID MESSENGER-RNA DECAY; NONSENSE-MEDIATED DECAY; EXON JUNCTION COMPLEX;
MENTAL-RETARDATION; PREFRONTAL CORTEX; NMD; MUTATIONS; PATHWAY; GENE;
SCHIZOPHRENIA
AB Background: Mutation in the UPF3B gene on chromosome X is implicated in neurodevelopmental disorders including X-linked intellectual disability, autism and schizophrenia. The protein UPF3B is involved in the nonsense-mediated mRNA decay pathway (NMD) that controls mRNA stability and functions in the prevention of the synthesis of truncated proteins.
Results: Here we show that NMD pathway components UPF3B and UPF1 are down-regulated during differentiation of neural stem cells into neurons. Using tethered function assays we found that UPF3B missense mutations described in families with neurodevelopmental disorders reduced the activity of UPF3B protein in NMD. In neural stem cells, UPF3B protein was detected in the cytoplasm and in the nucleus. Similarly in neurons, UPF3B protein was detected in neurites, the somatic cytoplasm and in the nucleus. In both cell types nuclear UPF3B protein was enriched in the nucleolus. Using GFP tagged UPF3B proteins we found that the missense mutations did not affect the cellular localisation. Expression of missense mutant UPF3B disturbed neuronal differentiation and reduced the complexity of the branching of neurites. Neuronal differentiation was similarly affected in the presence of the NMD inhibitor Amlexanox. The expression of mutant UPF3B proteins lead to a subtle increase in mRNA levels of selected NMD targets.
Conclusions: Together our findings indicate that, despite the down-regulation of NMD factors, functional NMD is critical for neuronal differentiation. We propose that the neurodevelopmental phenotype of UPF3B missense mutation is caused by impairment of NMD function altering neuronal differentiation.
C1 [Alrahbeni, Tahani; Sartor, Francesca; Anderson, Jihan; McCaig, Colin; Mueller, Berndt] Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland.
[Miedzybrodzka, Zosia] Med Genet, Aberdeen AB25 2ZD, Scotland.
RP Muller, B (reprint author), Univ Aberdeen, Inst Med Sci, Foresterhill, Aberdeen AB25 2ZD, Scotland.
EM b.mueller@abdn.ac.uk
FU Tenovus Scotland [G11-06]; Moonlight Prowl; Saudi Arabian Ministry of
Higher Education via King Abdullah Program; Medical Research Scotland
[PhD-654-2012]; Dundee Cell Products
FX We thank Fred H Gage (Salk Institute, La Jolla, CA, USA) for HCN-A94
cells and Niels Gehring (University of Cologne, Germany) for constructs.
We gratefully acknowledge Tenovus Scotland (Project Grant G11-06),
Moonlight Prowl (FS) and the Saudi Arabian Ministry of Higher Education
via King Abdullah Program for Scholarships for support (TA). JA is
supported by a PhD studentship from Medical Research Scotland
(PhD-654-2012) and Dundee Cell Products.
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NR 43
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1756-6606
J9 MOL BRAIN
JI Mol. Brain
PD MAY 27
PY 2015
VL 8
AR 33
DI 10.1186/s13041-015-0122-1
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA CI9FG
UT WOS:000355075200001
PM 26012578
ER
PT J
AU Mannik, K
Magi, R
Mace, A
Guyatt, AL
Shihab, HA
Maillard, AM
Alavere, H
Kolk, A
Reigo, A
Mihailov, E
Leitsalu, L
Ferreira, AM
Noukas, M
Teumer, A
Salvi, E
Cusi, D
Mcgue, M
Iacono, WG
Gaunt, T
Beckmann, JS
Jacquemont, S
Kutalik, Z
Pankratz, N
Timpson, N
Metspalu, A
Reymond, A
AF Maennik, Katrin
Maegi, Reedik
Mace, Aurelien
Guyatt, Anna L.
Shihab, Hashem A.
Maillard, Anne M.
Alavere, Helene
Kolk, Anneli
Reigo, Anu
Mihailov, Evelin
Leitsalu, Liis
Ferreira, Anne-Maud
Noukas, Margit
Teumer, Alexander
Salvi, Erika
Cusi, Daniele
McGue, Matt
Iacono, William G.
Gaunt, Tomr.
Beckmann, Jacques S.
Jacquemont, Sebastien
Kutalik, Zoltan
Pankratz, Nathan
Timpson, Nicholas
Metspalu, Andres
Reymond, Alexandre
TI Copy Number Variations and Cognitive Phenotypes in Unselected
Populations
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID CHROMOSOME 16P11.2; GENOMIC DISORDERS; GENE-EXPRESSION; VARIANTS;
ASSOCIATION; INTELLIGENCE; AUTISM; DISEASE; ABILITY; OBESITY
AB IMPORTANCE The association of copy number variations (CNVs), differing numbers of copies of genetic sequence at locations in the genome, with phenotypes such as intellectual disability has been almost exclusively evaluated using clinically ascertained cohorts. The contribution of these genetic variants to cognitive phenotypes in the general population remains unclear.
OBJECTIVE To investigate the clinical features conferred by CNVs associated with known syndromes in adult carriers without clinical preselection and to assess the genome-wide consequences of rare CNVs (frequency <= 0.05%; size >= 250 kilobase pairs [kb]) on carriers' educational attainment and intellectual disability prevalence in the general population.
DESIGN, SETTING, AND PARTICIPANTS The population biobank of Estonia contains 52 000 participants enrolled from 2002 through 2010. General practitioners examined participants and filled out a questionnaire of health-and lifestyle-related questions, as well as reported diagnoses. Copy number variant analysis was conducted on a random sample of 7877 individuals and genotype-phenotype associations with education and disease traits were evaluated. Our results were replicated on a high-functioning group of 993 Estonians and 3 geographically distinct populations in the United Kingdom, the United States, and Italy.
MAIN OUTCOMES AND MEASURES Phenotypes of genomic disorders in the general population, prevalence of autosomal CNVs, and association of these variants with educational attainment (from less than primary school through scientific degree) and prevalence of intellectual disability.
RESULTS Of the 7877 in the Estonian cohort, we identified 56 carriers of CNVs associated with known syndromes. Their phenotypes, including cognitive and psychiatric problems, epilepsy, neuropathies, obesity, and congenital malformations are similar to those described for carriers of identical rearrangements ascertained in clinical cohorts. A genome-wide evaluation of rare autosomal CNVs (frequency, <= 0.05%; >= 250 kb) identified 831 carriers (10.5%) of the screened general population. Eleven of 216 (5.1%) carriers of a deletion of at least 250 kb (odds ratio [OR], 3.16; 95% CI, 1.51-5.98; P = 1.5e-03) and 6 of 102 (5.9%) carriers of a duplication of at least 1Mb (OR, 3.67; 95% CI, 1.29-8.54; P = .008) had an intellectual disability compared with 114 of 6819 (1.7%) in the Estonian cohort. The mean education attainment was 3.81 (P = 1.06e-04) among 248 (>= 250 kb) deletion carriers and 3.69 (P = 5.024e-05) among 115 duplication carriers (>= 1 Mb). Of the deletion carriers, 33.5% did not graduate from high school (OR, 1.48; 95% CI, 1.12-1.95; P = .005) and 39.1% of duplication carriers did not graduate high school (OR, 1.89; 95% CI, 1.27-2.8; P = 1.6e-03). Evidence for an association between rare CNVs and lower educational attainment was supported by analyses of cohorts of adults from Italy and the United States and adolescents from the United Kingdom.
CONCLUSIONS AND RELEVANCE Known pathogenic CNVs in unselected, but assumed to be healthy, adult populations may be associated with unrecognized clinical sequelae. Additionally, individually rare but collectively common intermediate-size CNVs may be negatively associated with educational attainment. Replication of these findings in additional population groups is warranted given the potential implications of this observation for genomics research, clinical care, and public health.
C1 [Maennik, Katrin; Ferreira, Anne-Maud; Reymond, Alexandre] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
[Maennik, Katrin; Maegi, Reedik; Alavere, Helene; Kolk, Anneli; Reigo, Anu; Mihailov, Evelin; Leitsalu, Liis; Noukas, Margit; Metspalu, Andres] Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.
[Mace, Aurelien; Maillard, Anne M.; Jacquemont, Sebastien; Kutalik, Zoltan] Univ Lausanne, Dept Med Genet, CH-1015 Lausanne, Switzerland.
[Mace, Aurelien; Ferreira, Anne-Maud; Beckmann, Jacques S.; Kutalik, Zoltan] Swiss Inst Bioinformat, Lausanne, Switzerland.
[Pankratz, Nathan] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
[Guyatt, Anna L.; Shihab, Hashem A.; Gaunt, Tomr.; Timpson, Nicholas] Univ Bristol, Sch Social & Community Med, Bristol Genet Epidemiol Labs, Bristol, Avon, England.
[Shihab, Hashem A.; Gaunt, Tomr.; Timpson, Nicholas] Univ Bristol, Sch Social & Community Med, MRC Integrat Epidemiol Unit, Bristol, Avon, England.
[Kolk, Anneli] Tartu Univ Hosp, Childrens Clin, Dept Neurol & Neurorehabil, Tartu, Estonia.
[Leitsalu, Liis; Noukas, Margit; Metspalu, Andres] Univ Tartu, Inst Mol & Cell Biol, EE-50090 Tartu, Estonia.
[Teumer, Alexander] Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
[Salvi, Erika; Cusi, Daniele] Univ Milan, Dept Hlth Sci, Milan, Italy.
[Cusi, Daniele] Italian Natl Res Council, Inst Biomed Technol, Milan, Italy.
[McGue, Matt; Iacono, William G.] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA.
[Kutalik, Zoltan] Lausanne Univ Hosp CHUV, Inst Social & Prevent Med, Lausanne, Switzerland.
RP Reymond, A (reprint author), Univ Lausanne, Ctr Integrat Genom, Genopode Bldg, CH-1015 Lausanne, Switzerland.
EM alexandre.reymond@unil.ch
FU Swiss Scientific Exchange New Member State of the European Union
Program; Wellcome Trust [102433/Z/13/Z]; SNSF [31003A_160203]; SNSF
Sinergia grant [CRSII33-133044]; Simons Foundation Autism Research
Initiative [SFARI274424]; Leenaards Foundation Prizes; European
Commission [278913, 306031, 313010]; Center of Excellence in Genomics
(EXCEGEN); University of Tartu [SP1GVARENG]; Estonian Research Council
[IUT20-60]; US Public Health Service grants from the National Institute
on Alcohol Abuse and Alcoholism [AA09367, AA11886]; National Institute
on Drug Abuse [DA05147, DA13240, DA024417]; National Institute of Mental
Health [MH066140]
FX Dr Mannik is a grantee of a scholarship from the Swiss Scientific
Exchange New Member State of the European Union Program. Ms Guyatt is
funded by a PhD studentship from the Wellcome Trust (grant
102433/Z/13/Z). Dr Jacquemont is a Bursary Professor of the Swiss
National Science Foundation (SNSF). This study is supported by 2 SNSF
grants (31003A_160203, Drs Reymond, and Kutalik), a specific 16p11.2
SNSF Sinergia grant (CRSII33-133044, Dr Reymond), the Simons Foundation
Autism Research Initiative (SFARI274424, Dr Reymond), Leenaards
Foundation Prizes (Drs Jacquemont, Reymond, and Kutalik), European
Commission Framework Program 7 grants (278913, 306031, and 313010) (Dr
Metspalu), Center of Excellence in Genomics (EXCEGEN) and University of
Tartu (SP1GVARENG, Dr Metspalu), Estonian Research Council Grant
(IUT20-60, Dr Metspalu), US Public Health Service grants from the
National Institute on Alcohol Abuse and Alcoholism (AA09367 and AA11886,
Dr Pankratz), the National Institute on Drug Abuse (DA05147, DA13240,
and DA024417, Dr Pankratz), and the National Institute of Mental Health
(MH066140, Dr Pankratz).
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NR 59
TC 1
Z9 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 26
PY 2015
VL 313
IS 20
BP 2044
EP 2054
DI 10.1001/jama.2015.4845
PG 11
WC Medicine, General & Internal
SC General & Internal Medicine
GA CJ0DC
UT WOS:000355142400018
PM 26010633
ER
PT J
AU Itahashi, T
Yamada, T
Watanabe, H
Nakamura, M
Ohta, H
Kanai, C
Iwanami, A
Kato, N
Hashimoto, R
AF Itahashi, Takashi
Yamada, Takashi
Watanabe, Hiromi
Nakamura, Motoaki
Ohta, Haruhisa
Kanai, Chieko
Iwanami, Akira
Kato, Nobumasa
Hashimoto, Ryu-ichiro
TI Alterations of local spontaneous brain activity and connectivity in
adults with high-functioning autism spectrum disorder
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum disorder; Resting-state functional magnetic resonance
imaging; Spontaneous activity; Local connectivity; Amplitude of
low-frequency fluctuation
ID SENTENCE COMPREHENSION; ALZHEIMERS-DISEASE; NETWORK CENTRALITY;
ASPERGERS SYNDROME; SYMPTOM SEVERITY; SOCIAL DEFICITS; FUSIFORM GYRUS;
GRAY-MATTER; QUOTIENT AQ; CORTEX
AB Background: Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear.
Methods: We acquired rsfMRI data from 50 adults with high-functioning ASD and 50 matched controls to examine the properties of spontaneous brain activity using measures of local and distant connectivity together with a measure of the amplitude of brain activity, known as fractional amplitude of low-frequency fluctuation (fALFF). The two connectivity measures were calculated using a common graph-theoretic framework. We also examined the spatial overlaps between these measures and possible relationships of these disrupted functional measures with autistic traits assessed by the Autism-Spectrum Quotient (AQ).
Results: Compared to the controls, participants with ASD exhibited local over-connectivity in the right superior frontal gyrus and middle frontal gyrus, accompanied by local under-connectivity in the bilateral fusiform gyri (FG) and right middle temporal gyrus (MTG). On the other hand, we did not find any significant alterations in distant connectivity. Participants with ASD also exhibited reduced fALFF in the right middle occipital gyrus, lingual gyrus, and FG. Further conjunction and spatial overlap analyses confirmed that the spatial pattern of reduced fALFF substantially overlapped with that of local under-connectivity, demonstrating the co-occurrence of disrupted connectivity and spontaneous activity level in the right inferior occipital gyrus, posterior MTG (pMTG), and FG. Finally, within the ASD group, disrupted local connectivity in the right pMTG significantly correlated with the "social interaction" subscale score of the AQ.
Conclusions: These findings revealed local functional disruptions in the occipital and temporal regions, especially the right FG and pMTG, in the form of co-occurrence of spontaneous brain activity level and local connectivity, which may underline social and communicative dysfunctions in adult ASD.
C1 [Itahashi, Takashi; Yamada, Takashi; Watanabe, Hiromi; Ohta, Haruhisa; Kanai, Chieko; Kato, Nobumasa; Hashimoto, Ryu-ichiro] Showa Univ, Med Inst Dev Disabil Res, Setagaya Ku, Tokyo, Japan.
[Yamada, Takashi; Watanabe, Hiromi; Nakamura, Motoaki; Ohta, Haruhisa; Iwanami, Akira] Showa Univ, Sch Med, Dept Psychiat, Setagaya Ku, Tokyo 142, Japan.
[Yamada, Takashi] ATR Brain Informat Commun Res Lab Grp, Kyoto, Japan.
[Nakamura, Motoaki] Kinko Hosp, Kanagawa Psychiat Ctr, Yokohama, Kanagawa, Japan.
[Hashimoto, Ryu-ichiro] Tokyo Metropolitan Univ, Dept Language Sci, Grad Sch Humanities, Hachioji, Tokyo, Japan.
RP Hashimoto, R (reprint author), Showa Univ, Med Inst Dev Disabil Res, Setagaya Ku, 6-11-11 Kita Karasuyama, Tokyo, Japan.
EM dbridges50@gmail.com
FU Japan Society for the Promotion of Science (JSPS) [25870738]; Ministry
of Education, Culture, Sports, Science, and Technology of Japan
[23118003]
FX This study is the result of "Development of BMI Technologies for
Clinical Application" carried out under the Strategic Research Program
for Brain Sciences by the Ministry of Education, Culture, Sports,
Science and Technology of Japan. This work was also supported by the
Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Young
Scientists (B) (25870738 to T.I.) and by a Grant-in-Aid for Scientific
Research on Innovative Areas (23118003; Adolescent Mind and
Self-Regulation to R.H.) from the Ministry of Education, Culture,
Sports, Science, and Technology of Japan.
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NR 91
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 24
PY 2015
VL 6
AR 30
DI 10.1186/s13229-015-0026-z
PG 14
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CJ2GQ
UT WOS:000355302600001
PM 26023326
ER
PT J
AU Rodriguez-Lopez, J
Carrera, N
Arrojo, M
Amigo, J
Sobrino, B
Paramo, M
Paz, E
Agra, S
Ramos-Rios, R
Brenlla, J
Carracedo, A
Costas, J
AF Rodriguez-Lopez, Julio
Carrera, Noa
Arrojo, Manuel
Amigo, Jorge
Sobrino, Beatriz
Paramo, Mario
Paz, Eduardo
Agra, Santiago
Ramos-Rios, Ramon
Brenlla, Julio
Carracedo, Angel
Costas, Javier
TI An efficient screening method for simultaneous detection of recurrent
copy number variants associated with psychiatric disorders
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Copy number variants; Quantitative interspecies competitive PCR;
Psychiatric genetics; Schizophrenia; Autism
ID SCHIZOPHRENIA
AB Several recurrent copy number variants (CNVs) increasing risk to neuropsychiatric diseases have been identified in recent years. They show variable clinical expressivity, being associated with different disorders, and incomplete penetrance. However, due to its very low frequency, the full variety of clinical outcomes associated with each one of these CNVs is unknown. Current methods for detection of CNVs are labor intensive, expensive or not suitable for high throughput analysis. Quantitative interspecies competitive PCR linked to variant minisequencing and detection by mass-spectrometry may overcome these limitations. Here, we present two multiplex assays based on this method to screen for eleven psychiatric risk CNVs, such as 1q21, 16p11.2, 3q29, or 16p13.11 regions, among others. The assays were tested in our collection of 514 schizophrenia patients. Results were compared with MLPA at two CNVs. Additional positive results were confirmed by exome sequencing. A total of fourteen patients were CNV carriers. The method presents high sensitivity and specificity, showing its utility as a cheap, accurate, high throughput screening tool for recurrent CNVs. The method may be very useful for management of psychiatric patients as well as screening of different collections of samples to better identify the full spectrum of clinical variability. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Rodriguez-Lopez, Julio; Carrera, Noa; Arrojo, Manuel; Amigo, Jorge; Paramo, Mario; Paz, Eduardo; Agra, Santiago; Ramos-Rios, Ramon; Brenlla, Julio; Carracedo, Angel; Costas, Javier] Inst Invest Sanitaria IDIS Santiago de Compostela, Serv Galego Saude SERGAS, Santiago De Compostela, Spain.
[Rodriguez-Lopez, Julio; Carrera, Noa; Sobrino, Beatriz; Carracedo, Angel] Fdn Pabl Galega Med Xenom, Santiago De Compostela, Spain.
[Arrojo, Manuel; Paramo, Mario; Paz, Eduardo; Agra, Santiago; Ramos-Rios, Ramon; Brenlla, Julio] Complexo Hospt Univ Santiago de Compostela, Serv Psiquiatr, Serv Galego Saude SERGAS, Santiago De Compostela, Spain.
[Amigo, Jorge; Carracedo, Angel] Univ Santiago Compostela, Grp Med Xenom, Santiago De Compostela, Spain.
RP Costas, J (reprint author), Hosp Clin Univ, Inst Invest Sanitaria IDIS Santiago de Compostela, Grp Xenet Psiquiatr, Edificio Consultas,Andar 2,Despacho 15, E-15706 Santiago De Compostela, Spain.
EM javier.costas.costas@sergas.es
RI Costas, Javier/B-5016-2008
OI Costas, Javier/0000-0003-0306-3990
FU Instituto de Salud Carlos III/FEDER [CP11/00163]
FX This work was supported by grant CP11/00163 from Instituto de Salud
Carlos III/FEDER to JC. Genotyping was performed at the Santiago de
Compostela node of Centro Nacional de Genotipado. We thank Maria Torres
and Juan Ansede for their technical assistance.
CR Aradhya S, 2013, CURR GENET MED REP, V1, P71
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NR 23
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD MAY 20
PY 2015
VL 445
BP 34
EP 40
DI 10.1016/j.cca.2015.03.013
PG 7
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA CI8LP
UT WOS:000355024100007
PM 25797897
ER
PT J
AU Chen, L
Tai, WCS
Brar, MS
Leung, FCC
Hsiao, WLW
AF Chen, Lei
Tai, William C. S.
Brar, Manreetpal S.
Leung, Frederick C. C.
Hsiao, W. L. Wendy
TI Tumor Grafting Induces Changes of Gut Microbiota in Athymic Nude Mice in
the Presence and Absence of Medicinal Gynostemma Saponins
SO PLOS ONE
LA English
DT Article
ID IRRITABLE-BOWEL-SYNDROME; ABERRANT CRYPT FOCI; INTESTINAL MICROBIOTA;
BETA-GLUCURONIDASE; ALLERGIC DISEASES; TOXICITY; DIETARY; OBESITY;
CELLS; MICROFLORA
AB Recent findings have revealed that gut microbiota plays a substantial role in modulating diseases such as autism, rheumatoid arthritis, allergies, and cancer that occur at sites distant to the gut. Athymic nude mice have been employed for tumorigenic research for decades; however, the relationships between the gut microbiome and host's response in drug treatment to the grafted tumors have not been explored. In this study, we analyzed the fecal microbiome of nonxenograft and xenograft nude mice treated with phytosaponins from a popular medicinal plant, Gynostemma pentaphyllum (Gp). Analysis of enterobacterial repetitive intergenic consensus (ERIC)-PCR data showed that the microbiota profile of xenograft mice departed from that of the nonxenograft mice. After ten days of treatment with Gp saponins (GpS), the microbiota of the treated mice was closer to the microbiota at Day 0 before the implantation of the tumor. Data obtained from 16S pyrosequencing of fecal samples reiterates the differences in microbiome between the nonxenograft and xenograft mice. GpS markedly increased the relative abundance of Clostridium cocleatum and Bacteroides acidifaciens, for which the beneficial effects on the host have been well documented. This study, for the first time, characterizes the properties of gut microbiome in nude mice responding to tumor implant and drug treatment. We also demonstrate that dietary saponins such as GpS can potentially regulate the gut microbial ecosystem by increasing the number of symbionts. Interestingly, this regulation of the gut ecosystem might, at least in part, be responsible for or contribute to the anticancer effect of GpS.
C1 [Hsiao, W. L. Wendy] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
[Chen, Lei; Tai, William C. S.; Hsiao, W. L. Wendy] Hong Kong Baptist Univ, Sch Chinese Med, Ctr Canc & Inflammat Res, Kowloon, Hong Kong, Peoples R China.
[Brar, Manreetpal S.; Leung, Frederick C. C.] Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China.
RP Hsiao, WLW (reprint author), Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
EM wlhsiao@must.edu.mo
FU Research Grants Council of Hong Kong [GRF260413]
FX This work was partially supported by Research Grants Council of Hong
Kong under GRF260413 to W. L. Wendy Hsiao. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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NR 52
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 20
PY 2015
VL 10
IS 5
AR e0126807
DI 10.1371/journal.pone.0126807
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CI7CV
UT WOS:000354921400078
PM 25992551
ER
PT J
AU Mandic-Maravic, V
Pejovic-Milovancevic, M
Mitkovic-Voncina, M
Kostic, M
Aleksic-Hil, O
Radosavljev-Kircanski, J
Mincic, T
Lecic-Tosevski, D
AF Mandic-Maravic, Vanja
Pejovic-Milovancevic, Milica
Mitkovic-Voncina, Marija
Kostic, Milutin
Aleksic-Hil, Olivera
Radosavljev-Kircanski, Jelena
Mincic, Teodora
Lecic-Tosevski, Dusica
TI Sex Differences in Autism Spectrum Disorders: Does Sex Moderate the
Pathway from Clinical Symptoms to Adaptive Behavior?
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGHER FUNCTIONING INDIVIDUALS; COMMUNICATION ABILITIES; CHILDHOOD
AUTISM; CLASSIFICATION; DISABILITIES; TODDLERS; GIRLS; ADOS
AB We explored sex differences in diagnostic categories, clinical symptoms and adaptive behavior of persons with autism spectrum disorders, as well as sex-specific correlations of clinical and adaptive caracteristics. The study involved 108 patients (83 males, 6.73 + 4.33 years old) diagnosed with autism spectrum disorders (ASD). Assessment included ADI-R and Vineland Adaptive Behavior Scale II. Males were more often diagnosed with typical autism. There were no sex differences in the autistic symptoms, while females showed better functioning in Daily living skills, without reaching statistically significant difference (p = 0.062). We have found different associations of autistic symptoms with different aspects of adaptive behavior in males and females. Social reciprocity in females correlated with social domain of adaptive behavior, in a positive direction. Our findings have shown that although there are no sex differences in autistic symptoms, females tend to be somewhat more functional, and are also less frequently diagnosed with typical autism. Our results have also shown that sex might moderate the way clinical symptoms are expressed in adaptive behavior. Social reciprocity might be the core feature regarding sex differences in ASD. Our findings might have diagnostic and therapeutical implications, pointing out to the need for individualized, sex-specific treatment in this group of disorders.
C1 [Mandic-Maravic, Vanja; Pejovic-Milovancevic, Milica; Mitkovic-Voncina, Marija; Kostic, Milutin; Aleksic-Hil, Olivera; Radosavljev-Kircanski, Jelena; Mincic, Teodora; Lecic-Tosevski, Dusica] Inst Mental Hlth, Belgrade, Serbia.
[Pejovic-Milovancevic, Milica; Mitkovic-Voncina, Marija; Lecic-Tosevski, Dusica] Univ Belgrade, Sch Med, Belgrade, Serbia.
[Radosavljev-Kircanski, Jelena] Univ Singidunum, Fac Media & Commun, Belgrade, Serbia.
[Lecic-Tosevski, Dusica] Serbian Acad Arts & Sci, Belgrade, Serbia.
RP Pejovic-Milovancevic, M (reprint author), Inst Mental Hlth, Palmoticeva 37, Belgrade, Serbia.
EM milica.pejovic@imh.org.rs
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NR 37
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 19
PY 2015
VL 5
AR 10418
DI 10.1038/srep10418
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CJ2GF
UT WOS:000355301500001
PM 25988942
ER
PT J
AU Zaidel, A
Goin-Kochel, RP
Angelaki, DE
AF Zaidel, Adam
Goin-Kochel, Robin P.
Angelaki, Dora E.
TI Self-motion perception in autism is compromised by visual noise but
integrated optimally across multiple senses
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE autism; multisensory integration; noise; coherence; Bayesian
ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; MULTISENSORY INTEGRATION;
HEADING PERCEPTION; VESTIBULAR SIGNALS; CHILDREN; COHERENCE; DEFICITS;
FORM; INFORMATION
AB Perceptual processing in autism spectrum disorder (ASD) is marked by superior low-level task performance and inferior complex-task performance. This observation has led to theories of defective integration in ASD of local parts into a global percept. Despite mixed experimental results, this notion maintains widespread influence and has also motivated recent theories of defective multisensory integration in ASD. Impaired ASD performance in tasks involving classic random dot visual motion stimuli, corrupted by noise as a means to manipulate task difficulty, is frequently interpreted to support this notion of global integration deficits. By manipulating task difficulty independently of visual stimulus noise, here we test the hypothesis that heightened sensitivity to noise, rather than integration deficits, may characterize ASD. We found that although perception of visual motion through a cloud of dots was unimpaired without noise, the addition of stimulus noise significantly affected adolescents with ASD, more than controls. Strikingly, individuals with ASD demonstrated intact multisensory (visual-vestibular) integration, even in the presence of noise. Additionally, when vestibular motion was paired with pure visual noise, individuals with ASD demonstrated a different strategy than controls, marked by reduced flexibility. This result could be simulated by using attenuated (less reliable) and inflexible (not experience-dependent) Bayesian priors in ASD. These findings question widespread theories of impaired global and multisensory integration in ASD. Rather, they implicate increased sensitivity to sensory noise and less use of prior knowledge in ASD, suggesting increased reliance on incoming sensory information.
C1 [Zaidel, Adam; Angelaki, Dora E.] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA.
[Goin-Kochel, Robin P.] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
[Zaidel, Adam] Bar Ilan Univ, Gonda Multidisciplinary Brain Res Ctr, IL-52900 Ramat Gan, Israel.
RP Zaidel, A (reprint author), Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA.
EM adam.zaidel@biu.ac.il; angelaki@bcm.edu
FU Simons Foundation [SFARI 247992]
FX We thank Eric Raap and Alan Lin for help with data collection. This work
was supported by Simons Foundation Grant SFARI 247992 (to D.E.A.).
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 60
TC 0
Z9 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 19
PY 2015
VL 112
IS 20
BP 6461
EP 6466
DI 10.1073/pnas.1506582112
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CI4OD
UT WOS:000354729500069
PM 25941373
ER
PT J
AU Uddin, M
Codner, D
Hasan, SMM
Scherer, SW
O'Rielly, DD
Rahman, P
AF Uddin, Mohammed
Codner, Dianne
Hasan, S. M. Mahmud
Scherer, Stephen W.
O'Rielly, Darren D.
Rahman, Proton
TI Integrated Genomics Identifies Convergence of Ankylosing Spondylitis
with Global Immune Mediated Disease Pathways
SO SCIENTIFIC REPORTS
LA English
DT Article
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; CYTOKINE PRODUCTION;
T-CELLS; VARIANTS; NETWORK; POLYMORPHISMS; PHENOTYPE; PSORIASIS; REVEALS
AB Ankylosing spondylitis(AS), a highly heritable complex inflammatory arthritis. Although, a handful of non-HLA risk loci have been identified, capturing the unexplained genetic contribution to AS pathogenesis remains a challenge attributed to additive, pleiotropic and epistatic-interactions at the molecular level. Here, we developed multiple integrated genomic approaches to quantify molecular convergence of non-HLA loci with global immune mediated diseases. We show that non-HLA genes are significantly sensitive to deleterious mutation accumulation in the general population compared with tolerant genes. Human developmental proteomics (prenatal to adult) analysis revealed that proteins encoded by non-HLA AS risk loci are 2-fold more expressed in adult hematopoietic cells. Enrichment analysis revealed AS risk genes overlap with a significant number of immune related pathways (p < 0.0001 to 9.8 x 10(-12)). Protein-protein interaction analysis revealed non-shared AS risk genes are highly clustered seeds that significantly converge (empirical; p < 0.01 to 1.6 x 10(-4)) into networks of global immune mediated disease risk loci. We have also provided initial evidence for the involvement of STAT(2/3) in AS pathogenesis. Collectively, these findings highlight molecular insight on non-HLA AS risk loci that are not exclusively connected with overlapping immune mediated diseases; rather a component of common pathophysiological pathways with other immune mediated diseases. This information will be pivotal to fully explain AS pathogenesis and identify new therapeutic targets.
C1 [Uddin, Mohammed; Scherer, Stephen W.] Hosp Sick Children, Genet & Genome Biol, Toronto, ON M5G 1X8, Canada.
[Codner, Dianne; Hasan, S. M. Mahmud; O'Rielly, Darren D.; Rahman, Proton] Mem Univ Newfoundland, Fac Med, St John, NF, Canada.
[Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON, Canada.
[Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.
RP Rahman, P (reprint author), Mem Univ Newfoundland, Fac Med, St John, NF, Canada.
EM prahman@mun.ca
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NR 43
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 18
PY 2015
VL 5
AR 10314
DI 10.1038/srep10314
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CJ1VE
UT WOS:000355271900001
PM 25980808
ER
PT J
AU Chandley, MJ
Crawford, JD
Szebeni, A
Szebeni, K
Ordway, GA
AF Chandley, Michelle J.
Crawford, Jessica D.
Szebeni, Attila
Szebeni, Katalin
Ordway, Gregory A.
TI NTRK2 expression levels are reduced in laser captured pyramidal neurons
from the anterior cingulate cortex in males with autism spectrum
disorder
SO MOLECULAR AUTISM
LA English
DT Article
DE Pyramidal neurons; Astrocytes; Cingulate; Autism; Glutamate receptors
ID TYROSINE PROTEIN-KINASE; HIGH-FUNCTIONING AUTISM; FRAGILE-X-SYNDROME;
GENE-EXPRESSION; NEUROTROPHIC FACTOR; MESSENGER-RNA; MOUSE MODEL;
RAT-BRAIN; TRKB; CHILDREN
AB Background: The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain imaging studies demonstrate abnormalities of the ACC in ASD as compared to typically developing control patients. However, little is known regarding the cellular basis of these functional deficits in ASD. Pyramidal neurons in the ACC are excitatory glutamatergic neurons and key cellular mediators of the neural output of the ACC. This study was designed to investigate the potential role of ACC pyramidal neurons in ASD brain pathology.
Methods: Postmortem ACC tissue from carefully matched ASD and typically developing control donors was obtained from two national brain collections. Pyramidal neurons and surrounding astrocytes were separately collected from layer III of the ACC by laser capture microdissection. Isolated RNA was subjected to reverse transcription and endpoint PCR to determine gene expression levels for 16 synaptic genes relevant to glutamatergic neurotransmission. Cells were also collected from the prefrontal cortex (Brodmann area 10) to examine those genes demonstrating differences in expression in the ACC comparing typically developing and ASD donors.
Results: The level of NTRK2 expression was robustly and significantly lower in pyramidal neurons from ASD donors as compared to typically developing donors. Levels of expression of GRIN1, GRM8, SLC1A1, and GRIP1 were modestly lower in pyramidal neurons from ASD donors, but statistical significance for these latter genes did not survive correction for multiple comparisons. No significant expression differences of any genes were found in astrocytes laser captured from the same neocortical area. In addition, expression levels of NTRK2 and other synaptic genes were normal in pyramidal neurons laser captured from the prefrontal cortex.
Conclusions: These studies demonstrate a unique pathology of neocortical pyramidal neurons of the ACC in ASD. NTRK2 encodes the tropomyosin receptor kinase B (TrkB), transmission through which neurotrophic factors modify differentiation, plasticity, and synaptic transmission. Reduced pyramidal neuron NTRK2 expression in the ACC could thereby contribute to abnormal neuronal activity and disrupt social behavior mediated by this brain region.
C1 [Chandley, Michelle J.] E Tennessee State Univ, Coll Publ Hlth, Dept Hlth Sci, Johnson City, TN 37614 USA.
[Crawford, Jessica D.; Szebeni, Attila; Szebeni, Katalin; Ordway, Gregory A.] E Tennessee State Univ, James H Quillen Coll Med, Dept Biomed Sci, Johnson City, TN 37614 USA.
RP Ordway, GA (reprint author), E Tennessee State Univ, James H Quillen Coll Med, Dept Biomed Sci, POB 70582, Johnson City, TN 37614 USA.
EM ordway@etsu.edu
FU Autism Speaks pilot grant [7330]; National Institutes of Health
[RR030651]
FX The authors are grateful to the families who made the choice to consent
to donate brain tissue. This invaluable contribution will support many
years of ASD research. Human brain tissue was obtained from the Autism
Speaks Autism Tissue Program, the Harvard Brain Tissue Resource, and the
NICHD Brain and Tissue Bank for Developmental Disorders at the
University of Maryland, Baltimore, MD. Written informed consent was
obtained from the subject's next of kin for publication of their
individual details in this manuscript. The consent forms are held by the
above mentioned brain banks and are available for review by the
Editor-in-Chief. Autism Speaks pilot grant #7330 and the National
Institutes of Health RR030651 supported this research.
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NR 68
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 16
PY 2015
VL 6
AR 28
DI 10.1186/s13229-015-0023-2
PG 12
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CI6HP
UT WOS:000354859700001
PM 26000162
ER
PT J
AU Uno, Y
Uchiyama, T
Kurosawa, M
Aleksic, B
Ozaki, N
AF Uno, Yota
Uchiyama, Tokio
Kurosawa, Michiko
Aleksic, Branko
Ozaki, Norio
TI Early exposure to the combined measles-mumps-rubella vaccine and
thimerosal-containing vaccines and risk of autism spectrum disorder
SO VACCINE
LA English
DT Article
DE Autism Spectrum Disorder; Risk factor; Measles-Mumps-Rubella vaccine;
Thimerosal; Case-control study; Environmental factors
ID INFLAMMATORY-BOWEL-DISEASE; CHILD-HEALTH-HANDBOOK; MMR VACCINE;
COMMUNICATION DISORDERS; DIAGNOSTIC INTERVIEW; METAANALYSIS;
COMPLICATIONS; MERCURY
AB Objective: This case-control study investigated the relationship between the risk of Autism Spectrum Disorder (ASD) onset, and early exposure to the combined Measles-Mumps-Rubella (MMR) vaccine and thimerosal consumption measured from vaccinations in the highly genetically homogenous Japanese population.
Methods: Vaccination histories at 1, 3, 6, 12, 18, 24, and 36 months from birth were investigated in ASD cases (189 samples), and controls (224 samples) matching age and sex in each case. Crude odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to determine relationship between MMR vaccination and ASD. The differences in mean values of the thimerosal dosage between cases and controls were analyzed using an unpaired t-test. MMR vaccination and thimerosal dosage were also investigated using a conditional multiple-regression model.
Results: There were no significant differences in MMR vaccination and thimerosal dosage between cases and controls at any age. Furthermore, the ORs (95% CIs) of MMR vaccination and thimerosal dosage associated with ASD in the conditional multiple regression model were, respectively, 0.875(0.345-2.222) and 1.205(0.862-1.683) at age 18 months, 0.724(0.421-1.243) and 1.343(0.997-1.808) at 24 months, and 1.040(0.648-1.668) and 0.844(0.632-1.128) at 36 months. Thus, there were no significant differences.
Conclusions: No convincing evidence was found in this study that MMR vaccination and increasing thimerosal dose were associated with an increased risk of ASD onset. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Uno, Yota] Nagoya Univ, Grad Sch Med, Dept Child & Adolescent Psychiat, Showa Ku, Nagoya, Aichi 4668550, Japan.
[Uno, Yota; Uchiyama, Tokio] Yokohama Psychodev Clin, Dept Psychiat, Tsuzuki Ku, Yokohama, Kanagawa 2240032, Japan.
[Uchiyama, Tokio] Fukushima Univ, Grad Sch, Dept Fac Human Dev, Fukushima, Fukushima 9601248, Japan.
[Kurosawa, Michiko] Juntendo Univ, Grad Sch Med, Dept Epidemiol & Environm Hlth, Bunkyo Ku, Tokyo 1138421, Japan.
[Aleksic, Branko; Ozaki, Norio] Nagoya Univ, Grad Sch Med, Dept Psychiat, Showa Ku, Nagoya, Aichi 4668550, Japan.
RP Uno, Y (reprint author), Nagoya Univ, Grad Sch Med, Dept Child & Adolescent Psychiat, Showa Ku, Tsurumai Cho 65, Nagoya, Aichi 4668550, Japan.
EM yota_u@ypdc.net; tokiouch@ca2.so-net.ne.jp; mic@med.juntendo.ac.jp;
branko@med.nagoya-u.ac.jp; ozaki-n@med.nagoya-u.ac.jp
FU Ministry of Health, Labor and Welfare of Japan
[H22-Psychiatry-General-016]; Ministry of Education, Culture, Sports,
Science and Technology of Japan
FX The authors are grateful to Associate Professor Masahiko Ando, Nagoya
University Hospital, for his advice and checking of statistical
analyses. This study is the result of research grants from the Ministry
of Health, Labor and Welfare of Japan (H22-Psychiatry-General-016), and
"Integrated research on neuropsychiatric disorders" carried out under
the Strategic Research Program for Brain Sciences by the Ministry of
Education, Culture, Sports, Science and Technology of Japan.
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NR 49
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD MAY 15
PY 2015
VL 33
IS 21
BP 2511
EP 2516
DI 10.1016/j.vaccine.2014.12.036
PG 6
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CJ3AB
UT WOS:000355354700017
PM 25562790
ER
PT J
AU Yamamuro, K
Kimoto, S
Rosen, KM
Kishimoto, T
Makinodan, M
AF Yamamuro, Kazuhiko
Kimoto, Sohei
Rosen, Kenneth M.
Kishimoto, Toshifumi
Makinodan, Manabu
TI Potential primary roles of glial cells in the mechanisms of psychiatric
disorders
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Review
DE glia; schizophrenia; autism; mouse models; astrocytes; oligodenrocytes;
microglia; MeCP2
ID PELIZAEUS-MERZBACHER-DISEASE; CPG-BINDING PROTEIN-2; AMINO-ACID OXIDASE;
MUTANT HUMAN DISC1; RETT-SYNDROME; MOUSE MODEL; D-SERINE; SYNAPTIC
PLASTICITY; GENE-EXPRESSION; NERVOUS-SYSTEM
AB While neurons have long been considered the major player in multiple brain functions such as perception, emotion, and memory, glial cells have been relegated to a far lesser position, acting as merely a "glue" to support neurons. Multiple lines of recent evidence, however, have revealed that glial cells such as oligodendrocytes, astrocytes, and microglia, substantially impact on neuronal function and activities and are significantly involved in the underlying pathobiology of psychiatric disorders. Indeed, a growing body of evidence indicates that glial cells interact extensively with neurons both chemically (e.g., through neurotransmitters, neurotrophic factors, and cytokines) and physically (e.g., through gap junctions), supporting a role for these cells as likely significant modifiers not only of neural function in brain development but also disease pathobiology. Since questions have lingered as to whether glial dysfunction plays a primary role in the biology of neuropsychiatric disorders or a role related solely to their support of neuronal physiology in these diseases, informative and predictive animal models have been developed over the last decade. In this article, we review recent findings uncovered using glia-specific genetically modified mice with which we can evaluate both the causation of glia dysfunction and its potential role in neuropsychiatric disorders such as autism and schizophrenia.
C1 [Yamamuro, Kazuhiko; Kimoto, Sohei; Kishimoto, Toshifumi; Makinodan, Manabu] Nara Med Univ, Fac Med, Dept Psychiat, Kashihara, Nara 6348522, Japan.
[Rosen, Kenneth M.] BioAxone BioSci Inc, Cambridge, MA USA.
RP Makinodan, M (reprint author), Nara Med Univ, Fac Med, Dept Psychiat, 840 Shijo Cho, Kashihara, Nara 6348522, Japan.
EM mmm@naramed-u.ac.jp
FU Naito Foundation
FX This work was supported by the Naito Foundation.
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NR 128
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD MAY 15
PY 2015
VL 9
AR 154
DI 10.3389/fncel.2015.00154
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA CI5NS
UT WOS:000354804400001
PM 26029044
ER
PT J
AU Wang, YT
Sung, PY
Lin, PL
Yu, YW
Chung, RH
AF Wang, Yi-Ting
Sung, Pei-Yuan
Lin, Peng-Lin
Yu, Ya-Wen
Chung, Ren-Hua
TI A multi-SNP association test for complex diseases incorporating an
optimal P-value threshold algorithm in nuclear families
SO BMC GENOMICS
LA English
DT Article
ID CONTRASTING LINKAGE-DISEQUILIBRIUM; DISTANCE-BASED REGRESSION;
GENOME-WIDE ASSOCIATION; HAPLOTYPE SIMILARITY;
TRANSMISSION/DISEQUILIBRIUM TEST; GENERAL PEDIGREES; AUTISM; RISK; TOOL;
SIMULATION
AB Background: Genome-wide association studies (GWAS) have become a common approach to identifying single nucleotide polymorphisms (SNPs) associated with complex diseases. As complex diseases are caused by the joint effects of multiple genes, while the effect of individual gene or SNP is modest, a method considering the joint effects of multiple SNPs can be more powerful than testing individual SNPs. The multi-SNP analysis aims to test association based on a SNP set, usually defined based on biological knowledge such as gene or pathway, which may contain only a portion of SNPs with effects on the disease. Therefore, a challenge for the multi-SNP analysis is how to effectively select a subset of SNPs with promising association signals from the SNP set.
Results: We developed the Optimal P-value Threshold Pedigree Disequilibrium Test (OPTPDT). The OPTPDT uses general nuclear families. A variable p-value threshold algorithm is used to determine an optimal p-value threshold for selecting a subset of SNPs. A permutation procedure is used to assess the significance of the test. We used simulations to verify that the OPTPDT has correct type I error rates. Our power studies showed that the OPTPDT can be more powerful than the set-based test in PLINK, the multi-SNP FBAT test, and the p-value based test GATES. We applied the OPTPDT to a family-based autism GWAS dataset for gene-based association analysis and identified MACROD2-AS1 with genome-wide significance (p-value= 2.5 x 10(-6)).
Conclusions: Our simulation results suggested that the OPTPDT is a valid and powerful test. The OPTPDT will be helpful for gene-based or pathway association analysis. The method is ideal for the secondary analysis of existing GWAS datasets, which may identify a set of SNPs with joint effects on the disease.
C1 [Wang, Yi-Ting; Sung, Pei-Yuan] Natl Tsing Hua Univ, Inst Stat, Hsinchu, Taiwan.
[Lin, Peng-Lin] Natl Tsing Hua Univ, Dept Med Sci, Hsinchu, Taiwan.
[Yu, Ya-Wen; Chung, Ren-Hua] Natl Hlth Res Inst, Inst Populat Hlth Sci, Div Biostat & Bioinformat, Zhunan, Taiwan.
RP Chung, RH (reprint author), Natl Hlth Res Inst, Inst Populat Hlth Sci, Div Biostat & Bioinformat, Zhunan, Taiwan.
EM rchung@nhri.org.tw
FU Medical Research Council [G0601030]; Wellcome Trust [075491/Z/04];
National Health Research Institutes [PH-103-PP-15]; National Science
Council in Taiwan [NSC 102-2221-E-400-001-MY2]
FX We are grateful to the National Center for High-performance Computing in
Taiwan for computer time and facilities. The datasets used for the
analysis described in this manuscript were obtained from dbGaP at
http://www.ncbi.nlm.nih.gov/gap through dbGaP accession number,
phs000267.v4.p2. Submission of the data, phs000267.v4.p2, to dbGaP was
provided by Dr. Bernie Devlin on behalf of the Autism Genome Project
(AGP). Collection and submission of the data to dbGaP were supported by
a grant from the Medical Research Council (G0601030) and the Wellcome
Trust (075491/Z/04), Anthony P. Monaco, P.I., University of Oxford. This
work was funded by grants from the National Health Research Institutes
(PH-103-PP-15) and National Science Council (NSC 102-2221-E-400-001-MY2)
in Taiwan.
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NR 47
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD MAY 15
PY 2015
VL 16
AR 381
DI 10.1186/s12864-015-1620-3
PG 10
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CI0KS
UT WOS:000354426600001
PM 25975968
ER
PT J
AU Ortiz-Rosario, A
Adeli, H
Buford, JA
AF Ortiz-Rosario, Alexis
Adeli, Hojjat
Buford, John A.
TI Wavelet methodology to improve single unit isolation in primary motor
cortex cells
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE Wavelet transform; Statistical thresholding; Spike sorting; Single
units; Principal component analysis; Neuronal cell isolation
ID EEG-BASED DIAGNOSIS; FUZZY SYNCHRONIZATION LIKELIHOOD; PRINCIPAL
COMPONENT ANALYSIS; NEURAL NETWORK METHODOLOGY; AUTISM SPECTRUM
DISORDER; ALZHEIMERS-DISEASE; SEIZURE DETECTION; SPIKE DETECTION;
EXTRACELLULAR RECORDINGS; ALGORITHM
AB The proper isolation of action potentials recorded extracellularly from neural tissue is an active area of research in the fields of neuroscience and biomedical signal processing. This paper presents an isolation methodology for neural recordings using the wavelet transform (WT), a statistical thresholding scheme, and the principal component analysis (PCA) algorithm. The effectiveness of five different mother wavelets was investigated: biorthogonal, Daubachies, discrete Meyer, symmetric, and Coifman; along with three different wavelet coefficient thresholding schemes: fixed form threshold, Stein's unbiased estimate of risk, and minimax; and two different thresholding rules: soft and hard thresholding. The signal quality was evaluated using three different statistical measures: mean-squared error, root-mean squared, and signal to noise ratio. The clustering quality was evaluated using two different statistical measures: isolation distance, and L-ratio. This research shows that the selection of the mother wavelet has a strong influence on the clustering and isolation of single unit neural activity, with the Daubachies 4 wavelet and minimax thresholding scheme performing the best. (C) 2015 Published by Elsevier B.V.
C1 [Ortiz-Rosario, Alexis; Adeli, Hojjat; Buford, John A.] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA.
[Adeli, Hojjat] Ohio State Univ, Dept Biomed Informat, Columbus, OH 43210 USA.
[Adeli, Hojjat] Ohio State Univ, Dept Civil & Environm Engn & Geodet Sci, Columbus, OH 43210 USA.
[Adeli, Hojjat] Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA.
[Adeli, Hojjat] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA.
[Buford, John A.] Ohio State Univ, Sch Hlth & Rehabil Sci, Div Phys Therapy, Columbus, OH 43210 USA.
RP Adeli, H (reprint author), Ohio State Univ, Dept Biomed Engn, 470 Hitchcock Hall,2070 Neil Ave, Columbus, OH 43210 USA.
EM adeli.1@osu.edu
FU NIH NINDS [R01 NS37822]
FX The authors thank Rebecca Slattery, Thomas Hirschauer and Amanda Jellick
for assistance in collecting the data used in this research. This work
was supported partially by NIH NINDS R01 NS37822.
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NR 62
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
EI 1872-678X
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD MAY 15
PY 2015
VL 246
BP 106
EP 118
DI 10.1016/j.jneumeth.2015.03.014
PG 13
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA CI1KC
UT WOS:000354502100010
PM 25794461
ER
PT J
AU Cloke, JM
Jacklin, DL
Winters, BD
AF Cloke, Jacob M.
Jacklin, Derek L.
Winters, Boyer D.
TI The neural bases of crossmodal object recognition in non-human primates
and rodents: A review
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Review
DE Binding; Cross-modal; Memory; Monkey; Multisensory; Rat
ID AUTISM SPECTRUM DISORDERS; VENTROLATERAL PREFRONTAL CORTEX;
MODALITY-SPECIFIC ATTENTION; POSTERIOR PARIETAL CORTEX; TOP-DOWN
FACILITATION; MULTISENSORY INTEGRATION; PERIRHINAL CORTEX;
TEMPORAL-LOBE; AUDIOVISUAL INTEGRATION; RETROSPLENIAL CORTEX
AB The ability to integrate information from different sensory modalities to form unique multisensory object representations is a highly adaptive cognitive function. Surprisingly, non-human animal studies of the neural substrates of this form of multisensory integration have been somewhat sparse until very recently, and this may be due in part to a relative paucity of viable testing methods. Here we review the historical development and use of various "crossmodal" cognition tasks for non-human primates and rodents, focusing on tests of "rossmodal object recognition", the ability to recognize an object across sensory modalities. Such procedures have great potential to elucidate the cognitive and neural bases of object representation as it pertains to perception and memory. Indeed, these studies have revealed roles in crossmodal cognition for various brain regions (e.g., prefrontal and temporal cortices) and neurochemical systems (e.g., acetylcholine). A recent increase in behavioral and physiological studies of crossmodal cognition in rodents augurs well for the future of this research area, which should provide essential information about the basic mechanisms of object representation in the brain, in addition to fostering a better understanding of the causes of, and potential treatments for, cognitive deficits in human diseases characterized by atypical multisensory integration. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Winters, Boyer D.] Univ Guelph, Dept Psychol, Guelph, ON N1G 2W1, Canada.
Univ Guelph, Collaborat Neurosci Program, Guelph, ON N1G 2W1, Canada.
RP Winters, BD (reprint author), Univ Guelph, Dept Psychol, Guelph, ON N1G 2W1, Canada.
EM bwinters@uoguelph.ca
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
[400176]; NSERC post-graduate scholarship; Ontario Graduate Scholarship
FX This work was supported by a Discovery Grant from the Natural Sciences
and Engineering Research Council of Canada (NSERC) (400176) to BDW, as
well as an NSERC post-graduate scholarship to JMC and an Ontario
Graduate Scholarship to DLJ.
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NR 192
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD MAY 15
PY 2015
VL 285
SI SI
BP 118
EP 130
DI 10.1016/j.bbr.2014.09.039
PG 13
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CG2CU
UT WOS:000353083300012
PM 25286314
ER
PT J
AU Grayson, B
Leger, M
Piercy, C
Adamson, L
Harte, M
Neill, JC
AF Grayson, Ben
Leger, Marianne
Piercy, Chloe
Adamson, Lisa
Harte, Michael
Neill, Joanna C.
TI Assessment of disease-related cognitive impairments using the novel
object recognition (NOR) task in rodents
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Object recognition; Alzheimer's disease; Schizophrenia; Parkinson's
disease; Autistic spectrum disorder; Traumatic brain injury
ID TRAUMATIC BRAIN-INJURY; AMYLOID PRECURSOR PROTEIN; TRANSGENIC MOUSE
MODEL; HIPPOCAMPAL CELL-PROLIFERATION; PRENATAL IMMUNE ACTIVATION;
ENVIRONMENTAL RISK-FACTORS; AUTISM SPECTRUM DISORDERS;
ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; MEMORY DEFICITS
AB The novel object recognition test (NOR) test is a two trial cognitive paradigm that assesses recognition memory. Recognition memory is disturbed in a range of human disorders and NOR is widely used in rodents for investigating deficits in a variety of animal models of human conditions where cognition is impaired. It possesses several advantages over more complex tasks that involve lengthy training procedures and/or food or water deprivation. It is quick to administer, non-rewarded, provides data quickly, cost effective and most importantly, ethologically relevant as it relies on the animal's natural preference for novelty. A PubMed search revealed over 900 publications in rats and mice using this task over the past 3 years with 34 reviews in the past 10 years, demonstrating its increasing popularity with neuroscientists. Although it is widely used in many disparate areas of research, no articles have systematically examined this to date, which is the subject of our review. We reveal that NOR may be used to study recognition memory deficits that occur in Alzheimer's disease and schizophrenia, where research is extensive, in Parkinson's disease and Autism Spectrum Disorders (ASD) where we observed markedly reduced numbers of publications. In addition, we review the use of NOR to study cognitive deficits induced by traumatic brain injury and cancer chemotherapy, not disorders per se, but situations in which cognitive deficits dramatically reduce the quality of life for those affected, see Fig. 1 for a summary. Our review reveals that, in all these animal models, the NOR test is extremely useful for identification of the cognitive deficits observed, their neural basis, and for testing the efficacy of novel therapeutic agents. Our conclusion is that NOR is of considerable value for cognitive researchers of all disciplines and we anticipate that its use will continue to increase due to its versatility and several other advantages, as detailed in this review. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Grayson, Ben; Leger, Marianne; Piercy, Chloe; Adamson, Lisa; Harte, Michael; Neill, Joanna C.] Univ Manchester, Manchester Pharm Sch, Manchester M13 9PT, Lancs, England.
RP Grayson, B (reprint author), Univ Manchester, Manchester Pharm Sch, Manchester M13 9PT, Lancs, England.
EM Ben.grayson@manchester.ac.uk; Joanna.neill@manchester.ac.uk
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NR 165
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD MAY 15
PY 2015
VL 285
SI SI
BP 176
EP 193
DI 10.1016/j.bbr.2014.10.025
PG 18
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CG2CU
UT WOS:000353083300017
PM 25447293
ER
PT J
AU Kastner, A
Begemann, M
Michel, TM
Everts, S
Stepniak, B
Bach, C
Poustka, L
Becker, J
Banaschewski, T
Dose, M
Ehrenreich, H
AF Kaestner, Anne
Begemann, Martin
Michel, Tanja Maria
Everts, Sarah
Stepniak, Beata
Bach, Christiane
Poustka, Luise
Becker, Joachim
Banaschewski, Tobias
Dose, Matthias
Ehrenreich, Hannelore
TI Autism beyond diagnostic categories: characterization of autistic
phenotypes in schizophrenia
SO BMC PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorders; Positive and negative syndrome scale; Autism
diagnostic observation schedule; Diagnostics; Autism quotient; Empathy
quotient; Adults
ID OBSERVATION SCHEDULE; SPECTRUM DISORDER; COGNITIVE PERFORMANCE;
PSYCHIATRIC-DISORDERS; FUNCTIONING AUTISM; GENERAL-POPULATION; CLOZAPINE
RESPONSE; ASPERGER-SYNDROME; BIPOLAR DISORDER; GENETIC OVERLAP
AB Background: Behavioral phenotypical continua from health to disease suggest common underlying mechanisms with quantitative rather than qualitative differences. Until recently, autism spectrum disorders and schizophrenia were considered distinct nosologic entities. However, emerging evidence contributes to the blurring of symptomatic and genetic boundaries between these conditions. The present study aimed at quantifying behavioral phenotypes shared by autism spectrum disorders and schizophrenia to prepare the ground for biological pathway analyses.
Methods: Specific items of the Positive and Negative Syndrome Scale were employed and summed up to form a dimensional autism severity score (PAUSS). The score was created in a schizophrenia sample (N = 1156) and validated in adult high-functioning autism spectrum disorder (ASD) patients (N = 165). To this end, the Autism Diagnostic Observation Schedule (ADOS), the Autism (AQ) and Empathy Quotient (EQ) self-rating questionnaires were applied back to back with the newly developed PAUSS.
Results: PAUSS differentiated between ASD, schizophrenia and a disease-control sample and substantially correlated with the Autism Diagnostic Observation Schedule. Patients with ADOS scores >= 12 obtained highest, those with scores <7 lowest PAUSS values. AQ and EQ were not found to vary dependent on ADOS diagnosis. ROC curves for ADOS and PAUSS resulted in AuC values of 0.9 and 0.8, whereas AQ and EQ performed at chance level in the prediction of ASD.
Conclusions: This work underscores the convergence of schizophrenia negative symptoms and autistic phenotypes. PAUSS evolved as a measure capturing the continuous nature of autistic behaviors. The definition of extreme-groups based on the dimensional PAUSS may permit future investigations of genetic constellations modulating autistic phenotypes.
C1 [Kaestner, Anne; Begemann, Martin; Everts, Sarah; Stepniak, Beata; Becker, Joachim; Ehrenreich, Hannelore] Max Planck Inst Expt Med, Clin Neurosci, D-37075 Gottingen, Germany.
[Begemann, Martin; Ehrenreich, Hannelore] DFG Res Ctr Nanoscale Microscopy & Mol Physiol Br, Gottingen, Germany.
[Michel, Tanja Maria] Univ Southern Denmark, Inst Clin Res, Dept Psychiat, Odense, Denmark.
[Bach, Christiane; Poustka, Luise; Banaschewski, Tobias] Cent Inst Mental Hlth, Child & Adolescent Psychiat & Psychotherapy, Mannheim, Germany.
[Dose, Matthias] Kbo Isar Amper Klinikum Taufkirchen, Taufkirchen, Vils, Germany.
RP Ehrenreich, H (reprint author), Max Planck Inst Expt Med, Clin Neurosci, Hermann Rein Str 3, D-37075 Gottingen, Germany.
EM ehrenreich@em.mpg.de
FU Max Planck Society; Max Planck Forderstiftung; DFG (CNMPB); EXTRABRAIN
EU-FP7; EU-AIMS; Innovative Medicines Initiative Joint Undertaking
[115300]; European Union's Seventh Framework Programme (FP7); EFPIA
companies; Autism Speaks
FX This work was supported by the Max Planck Society, the Max Planck
Forderstiftung, the DFG (CNMPB), EXTRABRAIN EU-FP7, as well as by
EU-AIMS. The research of EU-AIMS receives support from the Innovative
Medicines Initiative Joint Undertaking under grant agreement
no 115300, resources of which are composed of financial
contribution from the European Union's Seventh Framework Programme
(FP7/2007-2013), from the EFPIA companies, and from Autism Speaks. We
are indebted to all individuals participating in the studies, and to all
collaborating schizophrenia and autism centers for their support. We are
grateful to all colleagues who contributed over the last decade to the
GRAS and validation sample data collection.
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NR 52
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 13
PY 2015
VL 15
AR 115
DI 10.1186/s12888-015-0494-x
PG 12
WC Psychiatry
SC Psychiatry
GA CI6HL
UT WOS:000354859300001
PM 25968177
ER
PT J
AU Schaschl, H
Huber, S
Schaefer, K
Windhager, S
Wallner, B
Fieder, M
AF Schaschl, Helmut
Huber, Susanne
Schaefer, Katrin
Windhager, Sonja
Wallner, Bernard
Fieder, Martin
TI Signatures of positive selection in the cis-regulatory sequences of the
human oxytocin receptor (OXTR) and arginine vasopressin receptor 1a
(AVPR1A) genes
SO BMC EVOLUTIONARY BIOLOGY
LA English
DT Article
DE Oxytocin receptor; Arginine vasopressin 1a receptor; Positive selection;
Balancing selection; Genetic diversity
ID DEFICIT HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDER;
SOCIAL-BEHAVIOR; POPULATION-STRUCTURE; EMOTION RECOGNITION; FACIAL
EXPRESSIONS; MENTAL-RETARDATION; ASSOCIATION; POLYMORPHISMS; DEPRESSION
AB Background: The evolutionary highly conserved neurohypophyseal hormones oxytocin and arginine vasopressin play key roles in regulating social cognition and behaviours. The effects of these two peptides are meditated by their specific receptors, which are encoded by the oxytocin receptor (OXTR) and arginine vasopressin receptor 1a genes (AVPR1A), respectively. In several species, polymorphisms in these genes have been linked to various behavioural traits. Little, however, is known about whether positive selection acts on sequence variants in genes influencing variation in human behaviours.
Results: We identified, in both neuroreceptor genes, signatures of balancing selection in the cis-regulative acting sequences such as transcription factor binding and enhancer sequences, as well as in a transcriptional repressor sequence motif. Additionally, in the intron 3 of the OXTR gene, the SNP rs59190448 appears to be under positive directional selection. For rs59190448, only one phenotypical association is known so far, but it is in high LD' (>0.8) with loci of known association; i.e., variants associated with key pro-social behaviours and mental disorders in humans.
Conclusions: Only for one SNP on the OXTR gene (rs59190448) was a sign of positive directional selection detected with all three methods of selection detection. For rs59190448, however, only one phenotypical association is known, but rs59190448 is in high LD' (>0.8), with variants associated with important pro-social behaviours and mental disorders in humans. We also detected various signatures of balancing selection on both neuroreceptor genes.
C1 [Schaschl, Helmut; Huber, Susanne; Schaefer, Katrin; Windhager, Sonja; Wallner, Bernard; Fieder, Martin] Univ Vienna, Dept Anthropol, Vienna, Austria.
[Wallner, Bernard] Univ Vienna, Cognit Sci Platform, Vienna, Austria.
[Wallner, Bernard] Univ Vienna, Dept Behav Biol, Vienna, Austria.
RP Fieder, M (reprint author), Univ Vienna, Dept Anthropol, Vienna, Austria.
EM martin.fieder@univie.ac.at
RI Wallner, Bernard/B-1089-2009
FU University of Vienna, Faculty of Life Sciences; University of Vienna [IP
547011]
FX The R Core Team for the statistical computing environment, the 1000
Genomes Project, as well as LOSITAN, BAYESCAN, and FLK. Furthermore, we
thank Michael Stachowitsch and the anonymous reviewers for valuable
comments on the manuscript. We would also like to thank Horst Seidler
for his continuing support. This work was supported by Young
Investigator Award 2013 University of Vienna, Faculty of Life Sciences,
to SW; Emerging Field "Comparative Human Life History: A Multilevel
Approach", University of Vienna, Faculty of Life Sciences, to KS;
Back-to-Research Grant, University of Vienna, to SH; and
Investitionsprojekt IP 547011, University of Vienna, to MF. The funders
had no role in study design, data collection and analysis, decision to
publish, or manuscript preparation. We thank the anonymous reviewers for
their very comments that significantly improved the manuscript.
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NR 78
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2148
J9 BMC EVOL BIOL
JI BMC Evol. Biol.
PD MAY 13
PY 2015
VL 15
AR 85
DI 10.1186/s12862-015-0372-7
PG 12
WC Evolutionary Biology; Genetics & Heredity
SC Evolutionary Biology; Genetics & Heredity
GA CH7YL
UT WOS:000354252600001
PM 25968600
ER
PT J
AU Gockley, J
Willsey, AJ
Dong, S
Dougherty, JD
Constantino, JN
Sanders, SJ
AF Gockley, Jake
Willsey, A. Jeremy
Dong, Shan
Dougherty, Joseph D.
Constantino, John N.
Sanders, Stephan J.
TI The female protective effect in autism spectrum disorder is not mediated
by a single genetic locus
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism spectrum disorder; Sex bias; Female protective effect; GWAS
ID DE-NOVO MUTATIONS; GENERAL-POPULATION; RISK; TRAITS; EPIDEMIOLOGY;
ASSOCIATION; RECURRENCE; EXPRESSION; VARIANTS; RESOURCE
AB Background: A 4:1 male to female sex bias has consistently been observed in autism spectrum disorder (ASD). Epidemiological and genetic studies suggest a female protective effect (FPE) may account for part of this bias; however, the mechanism of such protection is unknown. Quantitative assessment of ASD symptoms using the Social Responsiveness Scale (SRS) shows a bimodal distribution unique to females in multiplex families. This leads to the hypothesis that a single, common genetic locus on chromosome X might mediate the FPE and produce the ASD sex bias. Such a locus would represent a major therapeutic target and is likely to have been missed by conventional genome-wide association study (GWAS) analysis.
Methods: To explore this possibility, we performed an association study in affected versus unaffected females, considering three tiers of single nucleotide polymorphisms (SNPs) as follows: 1) regions of chromosome X that escape X-inactivation, 2) all of chromosome X, and 3) genome-wide.
Results: No evidence of a SNP meeting the criteria for a single FPE locus was observed, despite the analysis being well powered to detect this effect.
Conclusions: The results do not support the hypothesis that the FPE is mediated by a single genetic locus; however, this does not exclude the possibility of multiple genetic loci playing a role in the FPE.
C1 [Gockley, Jake; Willsey, A. Jeremy; Dong, Shan; Sanders, Stephan J.] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA.
[Willsey, A. Jeremy; Sanders, Stephan J.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
[Dong, Shan] Peking Univ, State Sch Life Sci, Ctr Bioinformat, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China.
[Dougherty, Joseph D.; Constantino, John N.] Washington Univ, Dept Psychiat, St Louis, MO 63110 USA.
[Dougherty, Joseph D.] Washington Univ, Dept Genet, St Louis, MO 63110 USA.
RP Constantino, JN (reprint author), Washington Univ, Dept Psychiat, 660 South Euclid Ave, St Louis, MO 63110 USA.
EM constantino@wustl.edu; stephan.sanders@ucsf.edu
RI ahmed, Jamila/E-8653-2015
FU Intellectual and Developmental Disabilities Research Center at
Washington University (NIH/NICHD) [P30 HD062171]; Simons Foundation
(SFARI) [307705]; Canadian Institutes of Health Research; [R01
HD042541]
FX This work was supported in part by grant R01 HD042541 to Dr.
Constantino, the Intellectual and Developmental Disabilities Research
Center at Washington University (NIH/NICHD P30 HD062171) to Dr.
Constantino, and a grant from the Simons Foundation (SFARI #307705) to
Dr. Sanders, and a Doctoral Foreign Study Award from the Canadian
Institutes of Health Research to Dr. Willsey. AGRE is a program of
Autism Speaks.
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NR 34
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 13
PY 2015
VL 6
AR 25
DI 10.1186/s13229-015-0014-3
PG 10
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CH9JC
UT WOS:000354350800002
PM 25973162
ER
PT J
AU Hu, VW
Sarachana, T
Sherrard, RM
Kocher, KM
AF Hu, Valerie W.
Sarachana, Tewarit
Sherrard, Rachel M.
Kocher, Kristen M.
TI Investigation of sex differences in the expression of RORA and its
transcriptional targets in the brain as a potential contributor to the
sex bias in autism
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism; RORA expression; Transcriptional targets; Sex differences;
Postmortem brain tissues; Mouse brain
ID DE-NOVO MUTATIONS; SPECTRUM DISORDERS; FETAL TESTOSTERONE;
GENE-EXPRESSION; NEURONAL DEVELOPMENT; MENTAL-RETARDATION;
ABNORMAL-BEHAVIOR; DENDRITIC GROWTH; PURKINJE-CELLS; ALPHA
AB Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant impairment in reciprocal social interactions and communication coupled with stereotyped, repetitive behaviors and restricted interests. Although genomic and functional studies are beginning to reveal some of the genetic complexity and underlying pathobiology of ASD, the consistently reported male bias of ASD remains an enigma. We have recently proposed that retinoic acid-related orphan receptor alpha (RORA), which is reduced in the brain and lymphoblastoid cell lines of multiple cohorts of individuals with ASD and oppositely regulated by male and female hormones, might contribute to the sex bias in autism by differentially regulating target genes, including CYP19A1 (aromatase), in a sex-dependent manner that can also lead to elevated testosterone levels, a proposed risk factor for autism.
Methods: In this study, we examine sex differences in RORA and aromatase protein levels in cortical tissues of unaffected and affected males and females by re-analyzing pre-existing confocal immunofluorescence data from our laboratory. We further investigated the expression of RORA and its correlation with several of its validated transcriptional targets in the orbital frontal cortex and cerebellum as a function of development using RNAseq data from the BrainSpan Atlas of the Developing Human Brain. In a pilot study, we also analyzed the expression of Rora and the same transcriptional targets in the cortex and cerebellum of adult wild-type male and female C57BL/6 mice.
Results: Our findings suggest that Rora/RORA and several of its transcriptional targets may exhibit sexually dimorphic expression in certain regions of the brain of both mice and humans. Interestingly, the correlation coefficients between Rora expression and that of its targets are much higher in the cortex of male mice relative to that of female mice. A strong positive correlation between the levels of RORA and aromatase proteins is also seen in the cortex of control human males and females as well as ASD males, but not ASD females.
Conclusions: Based on these studies, we suggest that disruption of Rora/RORA expression may have a greater impact on males, since sex differences in the correlation of RORA and target gene expression indicate that RORA-deficient males may experience greater dysregulation of genes relevant to ASD in certain brain regions during development.
C1 [Hu, Valerie W.; Sarachana, Tewarit; Kocher, Kristen M.] George Washington Univ, Sch Med & Hlth Sci, Dept Biochem & Mol Med, Washington, DC 20037 USA.
[Sarachana, Tewarit] Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Clin Chem, Bangkok, Thailand.
[Sherrard, Rachel M.] Univ Paris 06, Univ Paris 04, Inst Biol Paris Seine, CNRS,UMR Biol Adaptat & Aging 8256, F-75005 Paris, France.
RP Hu, VW (reprint author), George Washington Univ, Sch Med & Hlth Sci, Dept Biochem & Mol Med, 2300 Eye St NW, Washington, DC 20037 USA.
EM valhu@gwu.edu
RI ahmed, Jamila/E-8653-2015
FU Higher Educational Strategic Scholarship for Frontier Research Network
(SFR scholarship) from the Office of the Commission on Higher Education
of the Royal Thai Government, Thailand, through the Faculty of Allied
Health Sciences, Chulalongkorn University; NIEHS [R21 ES023061-01]
FX We wish to thank the families of all of the brain donors for their
invaluable gift to autism research and the Autism Tissue Program (San
Diego, CA, USA) for making frozen human brain tissues available for this
work through the Harvard Brain Tissue Resource Center (Harvard
University, Boston, MA, USA). We also thank the Allen Institute for
Brain Science (Seattle, WA, USA) and all the members of the consortium
working on the brain mapping project for making the RNAseq expression
data of the human brain publicly available. This study was supported in
part by generous gifts from the Ireland Family Foundation (Chapel Hill,
NC, USA) and the LIFE Foundation (Aspen, CO, USA), and by a grant from
the NIEHS (R21 ES023061-01). None of the funding sources played any role
in the study design, collection, analysis, and interpretation of data,
writing of the manuscript, or decision to submit this study for
publication. TS was a predoctoral student in the Institute for
Biomedical Sciences at the George Washington University, who was
supported by the Higher Educational Strategic Scholarship for Frontier
Research Network (SFR scholarship) from the Office of the Commission on
Higher Education of the Royal Thai Government, Thailand, through the
Faculty of Allied Health Sciences, Chulalongkorn University.
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NR 76
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 13
PY 2015
VL 6
AR 7
DI 10.1186/2040-2392-6-7
PG 18
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CH9JI
UT WOS:000354351400002
PM 26056561
ER
PT J
AU Lai, MC
Baron-Cohen, S
Buxbaum, JD
AF Lai, Meng-Chuan
Baron-Cohen, Simon
Buxbaum, Joseph D.
TI Understanding autism in the light of sex/gender
SO MOLECULAR AUTISM
LA English
DT Editorial Material
ID SPECTRUM DISORDERS; SEX-DIFFERENCES; ANOREXIA-NERVOSA; TRAITS; CHILDREN;
POPULATION; GENDER; ADULTS; IDENTIFICATION; FEMALES
C1 [Lai, Meng-Chuan; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 8AH, England.
[Lai, Meng-Chuan; Baron-Cohen, Simon] Cambridgeshire & Peterborough NHS Fdn Trust, Chitra Sethia Autism Ctr, CLASS Clin, Cambridge CB21 5EF, England.
[Lai, Meng-Chuan] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei 10051, Taiwan.
[Lai, Meng-Chuan] Coll Med, Taipei 10051, Taiwan.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Psychiat, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Friedman Brain Inst, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
RP Lai, MC (reprint author), Univ Cambridge, Dept Psychiat, Autism Res Ctr, Douglas House,18B,Trumpington Rd, Cambridge CB2 8AH, England.
EM mcl45@cam.ac.uk
RI ahmed, Jamila/E-8653-2015
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NR 62
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 13
PY 2015
VL 6
DI 10.1186/s13229-015-0021-4
PG 5
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CH9JC
UT WOS:000354350800001
PM 25973161
ER
PT J
AU Mandy, W
Tchanturia, K
AF Mandy, Will
Tchanturia, Kate
TI Do women with eating disorders who have social and flexibility
difficulties really have autism? A case series
SO MOLECULAR AUTISM
LA English
DT Article
DE Eating disorders; anorexia nervosa; Autism spectrum disorder (ASD);
gender differences; Autism Diagnostic Observation Schedule (ADOS);
clinical interview
ID ANOREXIA-NERVOSA; SPECTRUM DISORDERS; DIAGNOSTIC INTERVIEW; FUNCTIONING
AUTISM; ASPERGER-SYNDROME; ADOLESCENTS; TRAITS; ONSET; METAANALYSIS;
CHILDREN
AB Background: Many women with eating disorders (EDs) have social impairments and difficulties with flexibility. It is unclear to what extent these are manifestations of an underlying autism spectrum disorder (ASD); or whether they are instead the consequence of starvation, anxiety, low mood or obsessive compulsive disorder, all of which are highly prevalent in EDs. The resolution of this clinically and theoretically important uncertainty will require the use of gold-standard ASD assessment measures. To date these have not been employed in ED research. This case series is the first report of a well-validated, direct-observational measure of ASD, the Autism Diagnostic Observation Schedule (ADOS), being administered to women with EDs. We aimed to learn about the feasibility of the ADOS in this population, and to contribute to debates about whether a sub-group with EDs really have ASD.
Methods: Ten women (mean age = 26.4 years, range = 19 to 38 years) who had a suspected ASD due to social and flexibility difficulties and were receiving treatment for ED (seven anorexia, two ED not otherwise specified, one bulimia) at a specialist service (four inpatient, six outpatient) received an ADOS Module 4 assessment.
Results: All 10 participants completed all activities of the ADOS Module 4. Five scored in the ASD range on the ADOS diagnostic algorithm. An additional two were judged likely to have ASD, even though they scored below the ADOS's diagnostic threshold. This was on the basis of clinical observation, participant self-report and parent report. The seven women who we estimated to have ASD all reported autistic difficulties prior to the onset of their ED. They commonly described longstanding non-autistic neurodevelopmental problems, including dyslexia, dyspraxia and epilepsy. Only one had a childhood diagnosis of ASD.
Conclusions: A substantial proportion of women with EDs who present with social and flexibility difficulties may have an unrecognised ASD, indicated by a constellation of autistic difficulties that appears to predate the onset of their eating problems. The ADOS is a useful component of an ASD assessment for adult women with ED.
C1 [Mandy, Will] UCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 6BT, England.
[Tchanturia, Kate] Kings Coll London, Inst Psychiat, Psychol Med, London WC2R 2LS, England.
[Tchanturia, Kate] South London & Maudsley NHS Trust, Psychol Med Clin Acad Grp, London, England.
[Tchanturia, Kate] Illia State Univ, Tbilisi, Rep of Georgia.
RP Mandy, W (reprint author), UCL, Res Dept Clin Educ & Hlth Psychol, Gower St, London WC1E 6BT, England.
EM w.mandy@ucl.ac.uk
FU Maudsley Charity 'Health in Mind'
FX KT would like to thank the Maudsley Charity 'Health in Mind' for their
funding support. KT and WM thank the participants of this study, and the
clinical team at Maudsley Eating Disorder Adult National Service: Nikola
Kern, Catia Acosta, Danielle Glennon, Eli Doris, Caroline Fleming,
Elaine Smith and Victoria Mountford.
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American Psychiatric Association, 1994, DIAGN STAT MAN
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NR 54
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 13
PY 2015
VL 6
AR 6
DI 10.1186/2040-2392-6-6
PG 10
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CH9JI
UT WOS:000354351400001
PM 26056560
ER
PT J
AU Nordahl, CW
Iosif, AM
Young, GS
Perry, LM
Dougherty, R
Lee, A
Li, D
Buonocore, MH
Simon, T
Rogers, S
Wandell, B
Amaral, DG
AF Nordahl, Christine Wu
Iosif, Ana-Maria
Young, Gregory S.
Perry, Lee Michael
Dougherty, Robert
Lee, Aaron
Li, Deana
Buonocore, Michael H.
Simon, Tony
Rogers, Sally
Wandell, Brian
Amaral, David G.
TI Sex differences in the corpus callosum in preschool-aged children with
autism spectrum disorder
SO MOLECULAR AUTISM
LA English
DT Article
DE Connectivity; Diffusion tensor imaging; Longitudinal; MRI; White matter
ID PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC OBSERVATION SCHEDULE;
WHITE-MATTER; MRI DATA; FRONTAL-CORTEX; YOUNG-CHILDREN; DIFFUSION;
BRAIN; ENLARGEMENT; SIZE
AB Background: Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD.
Methods: Structural and diffusion-weighted images were acquired in 139 preschool-aged children with ASD (112 males/27 females) and 82 typically developing (TD) controls (53 males/29 females). Longitudinal scanning at two additional annual time points was carried out in a subset of these participants. Callosal organization was evaluated using two approaches: 1) diffusion tensor imaging (DTI) tractography to define subregions based on cortical projection zones and 2) as a comparison to previous studies, midsagittal area analysis using Witelson subdivisions. Diffusion measures of callosal fibers were also evaluated.
Results: Analyses of cortical projection zone subregions revealed sex differences in the patterns of altered callosal organization. Relative to their sex-specific TD counterparts, both males and females with ASD had smaller regions dedicated to fibers projecting to superior frontal cortex, but patterns differed in callosal subregions projecting to other parts of frontal cortex. While males with ASD had a smaller callosal region dedicated to the orbitofrontal cortex, females with ASD had a smaller callosal region dedicated to the anterior frontal cortex. There were also sex differences in diffusion properties of callosal fibers. While no alterations were observed in males with ASD relative to TD males, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were all increased in females with ASD relative to TD females. Analyses of Witelson subdivisions revealed a decrease in midsagittal area of the corpus callosum in both males and females with ASD but no regional differences in specific subdivisions. Longitudinal analyses revealed no diagnostic or sex differences in the growth rate or change in diffusion measures of the corpus callosum from 3 to 5 years of age.
Conclusions: There are sex differences in the pattern of altered corpus callosum neuroanatomy in preschool-aged children with ASD.
C1 [Nordahl, Christine Wu; Iosif, Ana-Maria; Young, Gregory S.; Lee, Aaron; Li, Deana; Simon, Tony; Rogers, Sally; Amaral, David G.] Univ Calif Davis, Sch Med, MIND Inst, Sacramento, CA 95817 USA.
[Nordahl, Christine Wu; Young, Gregory S.; Lee, Aaron; Li, Deana; Simon, Tony; Rogers, Sally; Amaral, David G.] Univ Calif Davis, Sch Med, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
[Iosif, Ana-Maria] Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Perry, Lee Michael; Wandell, Brian] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
[Dougherty, Robert] Stanford Univ, Ctr Cognit & Neurobiol Imaging, Stanford, CA 94305 USA.
[Buonocore, Michael H.] Univ Calif Davis, Sch Med, Dept Radiol, Sacramento, CA 95817 USA.
RP Nordahl, CW (reprint author), Univ Calif Davis, Sch Med, MIND Inst, 2805 50th St, Sacramento, CA 95817 USA.
EM crswu@ucdavis.edu
FU National Institute of Mental Health [R01 MH089626, U24 MH081810, R00
MH085099]; UC Davis MIND Institute; MIND Institute Intellectual and
Developmental Disabilities Research Center [U54 HD079125]
FX The authors would like to acknowledge Adam Wandell, Robert Scholz, and
Sarah Liston for their expert technical assistance and the Autism
Phenome Project staff for helping with the logistics of family visits
and data collection. We especially thank all of the families and
children who participated in the study. This work was supported by the
National Institute of Mental Health (R01 MH089626, U24 MH081810, R00
MH085099) and the UC Davis MIND Institute. Statistical support was
provided by the MIND Institute Intellectual and Developmental
Disabilities Research Center (U54 HD079125).
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NR 58
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 13
PY 2015
VL 6
AR 26
DI 10.1186/s13229-015-0005-4
PG 11
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CH9JC
UT WOS:000354350800003
PM 25973163
ER
PT J
AU Werling, DM
Geschwind, DH
AF Werling, Donna M.
Geschwind, Daniel H.
TI Recurrence rates provide evidence for sex-differential, familial genetic
liability for autism spectrum disorders in multiplex families and twins
SO MOLECULAR AUTISM
LA English
DT Article
DE Female protective model; Sex differences; Multiplex families; AGRE;
Recurrence risk; Interbirth interval
ID DE-NOVO MUTATIONS; COPY-NUMBER VARIATION; GENOME-WIDE; SUSCEPTIBILITY
LOCI; RESOURCE EXCHANGE; RISK LOCI; LINKAGE; EPIDEMIOLOGY; REPLICATION;
SIBLINGS
AB Background: Autism spectrum disorders (ASDs) are more prevalent in males, suggesting a multiple threshold liability model in which females are, on average, protected by sex-differential mechanisms. Under this model, autistic females are predicted to carry a more penetrant risk variant load than males and to share this greater genetic liability with their siblings. However, reported ASD recurrence rates have not demonstrated significantly increased risk to siblings of affected girls. Here, we characterize recurrence patterns in multiplex families from the Autism Genetics Resource Exchange (AGRE) to determine if risk in these families follows a female protective model.
Methods: We assess recurrence rates and quantitative traits in full siblings from 1,120 multiplex nuclear families and concordance rates in 305 twin pairs from AGRE. We consider the first two affected children per family, and one randomly selected autistic twin per pair, as probands. We then compare recurrence rates and phenotypes between males and females and between twin pairs or families with at least one female proband (female-containing (FC)) versus those with only male probands (male-only (MO)).
Results: Among children born after two probands, we observe significantly higher recurrence in males (47.5%) than in females (21.1%; relative risk, RR = 2.25; adjusted P = 6.22e-08) and in siblings of female (44.3%) versus siblings of male probands (30.4%; RR = 1.46; adj. P = 0.036). This sex-differential recurrence is also robust in dizygotic twin pairs (males = 61.5%, females = 19.1%; RR = 3.23; adj. P = 7.66e-09). Additionally, we find a significant negative relationship between interbirth interval and ASD recurrence that is driven by children in MO families.
Conclusions: By classifying families as MO or FC using two probands instead of one, we observe significant recurrence rate differences between families harboring sex-differential familial liability. However, a significant sex difference in risk to children within FC families suggests that female protective mechanisms are still operative in families carrying high genetic risk loads. Furthermore, the male-specific relationship between shorter interbirth intervals and increased ASD risk is consistent with a potentially greater contribution from environmental factors in males versus higher genetic risk in affected females and their families. Understanding the mechanisms driving these sex-differential risk profiles will be useful for treatment development and prevention.
C1 [Werling, Donna M.; Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.
[Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Neurogenet Program, Los Angeles, CA 90095 USA.
[Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA.
[Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Autism Res & Treatment, Semel Inst, Los Angeles, CA 90095 USA.
[Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Neurobehav Genet, Semel Inst, Los Angeles, CA 90095 USA.
[Geschwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.
RP Geschwind, DH (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, 760 Westwood Plaza, Los Angeles, CA 90095 USA.
EM dhg@mednet.ucla.edu
FU National Institute of Mental Health (NIMH) [1U24MH081810]; NIMH [F31
MH093086]; ACE Network grant [RO1 MH100027]; ACE Center grant [R01
MH071425]
FX We gratefully acknowledge resources provided by the Autism Genetics
Resource Exchange (AGRE) collection and the participating families, as
well as Clara M. Lajonchere and Eve Landa. Thank you also to Jennifer
Lowe for the assistance with data acquisition and management. AGRE is a
program of Autism Speaks and is supported, in part, by grant
1U24MH081810 from the National Institute of Mental Health (NIMH) to
Clara M. Lajonchere. DMW was supported by the NIMH F31 MH093086. This
work was additionally supported by ACE Network grant RO1 MH100027 and
ACE Center grant R01 MH071425 to DHG.
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NR 58
TC 1
Z9 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD MAY 13
PY 2015
VL 6
AR 27
DI 10.1186/s13229-015-0004-5
PG 14
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CH9JC
UT WOS:000354350800004
PM 25973164
ER
PT J
AU Vogt, D
Cho, KKA
Lee, AT
Sohal, VS
Rubenstein, JLR
AF Vogt, Daniel
Cho, Kathleen K. A.
Lee, Anthony T.
Sohal, Vikaas S.
Rubenstein, John L. R.
TI The Parvalbumin/Somatostatin Ratio Is Increased in Pten Mutant Mice and
by Human PTEN ASD Alleles
SO CELL REPORTS
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; CORTICAL INTERNEURONS; NEURODEVELOPMENTAL
DISORDERS; GAMMA-OSCILLATIONS; TENSIN HOMOLOG; MOUSE MODEL; CELLS;
BRAIN; ABNORMALITIES; INHIBITION
AB Mutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). Here, we investigate the function of Pten in cortical GABAergic neurons using conditional mutagenesis in mice. Loss of Pten results in a preferential loss of SST+ interneurons, which increases the ratio of parvalbumin/somatostatin (PV/SST) interneurons, ectopic PV+ projections in layer I, and inhibition onto glutamatergic cortical neurons. Pten mutant mice exhibit deficits in social behavior and changes in electroencephalogram (EEG) power. Using medial ganglionic eminence (MGE) transplantation, we test for cell-autonomous functional differences between human PTEN wild-type (WT) and ASD alleles. The PTEN ASD alleles are hypomorphic in regulating cell size and the PV/SST ratio in comparison to WT PTEN. This MGE transplantation/complementation assay is efficient and is generally applicable for functional testing of ASD alleles in vivo.
C1 [Vogt, Daniel; Cho, Kathleen K. A.; Lee, Anthony T.; Sohal, Vikaas S.; Rubenstein, John L. R.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94158 USA.
[Rubenstein, John L. R.] Univ Calif San Francisco, Neurosci Program, San Francisco, CA 94158 USA.
[Vogt, Daniel; Rubenstein, John L. R.] Univ Calif San Francisco, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94158 USA.
[Cho, Kathleen K. A.; Lee, Anthony T.; Sohal, Vikaas S.] Univ Calif San Francisco, Ctr Integrat Neurosci, San Francisco, CA 94143 USA.
[Cho, Kathleen K. A.; Lee, Anthony T.; Sohal, Vikaas S.] Univ Calif San Francisco, Sloan Swartz Ctr Theoret Neurobiol, San Francisco, CA 94143 USA.
RP Vogt, D (reprint author), Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94158 USA.
EM daniel.vogt@ucsf.edu; john.rubenstein@ucsf.edu
FU Autism Speaks; Weston Havens Foundation; NIMH [R01 MH081880, R37
MH049428, R01 MH100292]; International Mental Health Research
Organization; NIH [DP2 MH100011]; NARSAD Young Investigator Award from
the Brain and Behavior Foundation; Medical Scientist Training Program
grant from NIGMS [GM07618]; Nina Ireland; Staglin Family
FX This work was supported by grants to J.L.R.R. from Autism Speaks, Nina
Ireland, Weston Havens Foundation, NIMH R01 MH081880, and NIMH R37
MH049428. V.S.S. was supported by the Staglin Family and International
Mental Health Research Organization, NIH DP2 MH100011, and NIMH R01
MH100292. K.K.A.C. was supported by a NARSAD Young Investigator Award
from the Brain and Behavior Foundation. A.T.L. was supported by a
Medical Scientist Training Program grant from NIGMS (GM07618). J.L.R.R.
is a founding member and consultant for Neurona Therapeutics.
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NR 56
TC 0
Z9 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD MAY 12
PY 2015
VL 11
IS 6
BP 944
EP 956
DI 10.1016/j.celrep.2015.04.019
PG 13
WC Cell Biology
SC Cell Biology
GA CI0DT
UT WOS:000354406900011
PM 25937288
ER
PT J
AU Wang, H
Doering, LC
AF Wang, Hansen
Doering, Laurie C.
TI Autism spectrum disorders: emerging mechanisms and mechanism-based
treatment
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Editorial Material
DE autism spectrum disorders; fragile X syndrome; Rett syndrome;
pathogenesis; treatment; synaptic deficits; FMRP; MeCP2
ID FRAGILE-X-SYNDROME; RETT-SYNDROME; SYNAPTIC PLASTICITY; DEFICITS;
CONVERGENCE; DYSFUNCTION; SYNAPSES; PROTEINS; GENETICS; DEFECTS
C1 [Wang, Hansen] Univ Toronto, Fac Med, Toronto, ON, Canada.
[Doering, Laurie C.] McMaster Univ, Fac Hlth Sci, Dept Pathol & Mol Med, Hamilton, ON, Canada.
RP Wang, H (reprint author), Univ Toronto, Fac Med, Toronto, ON, Canada.
EM hansen.wang@utoronto.ca; doering@mcmaster.ca
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NR 45
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD MAY 12
PY 2015
VL 9
AR 183
DI 10.3389/fncel.7015.00183
PG 4
WC Neurosciences
SC Neurosciences & Neurology
GA CI5NL
UT WOS:000354803700001
PM 26029053
ER
PT J
AU Varea, O
Martin-de-Saavedra, MD
Kopeikina, KJ
Schurmann, B
Fleming, HJ
Fawcett-Patel, JM
Bach, A
Jang, S
Peles, E
Kim, E
Penzes, P
AF Varea, Olga
Martin-de-Saavedra, Maria Dolores
Kopeikina, Katherine J.
Schuermann, Britta
Fleming, Hunter J.
Fawcett-Patel, Jessica M.
Bach, Anthony
Jang, Seil
Peles, Elior
Kim, Eunjoon
Penzes, Peter
TI Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in
contactin associated protein-like 2/Caspr2 knockout neurons
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE CNTNAP2; synapse; AMPA; GluA1; schizophrenia
ID AUTISM SPECTRUM DISORDERS; BIPOLAR DISORDER; CNTNAP2; SCHIZOPHRENIA;
GENE; SYNAPSES; EPILEPSY; ADHESION; CONTACTIN-ASSOCIATED-PROTEIN-LIKE-2;
METAANALYSIS
AB Central glutamatergic synapses and the molecular pathways that control them are emerging as common substrates in the pathogenesis of mental disorders. Genetic variation in the contactin associated protein-like 2 (CNTNAP2) gene, including copy number variations, exon deletions, truncations, single nucleotide variants, and polymorphisms have been associated with intellectual disability, epilepsy, schizophrenia, language disorders, and autism. CNTNAP2, encoded by Cntnap2, is required for dendritic spine development and its absence causes disease-related phenotypes in mice. However, the mechanisms whereby CNTNAP2 regulates glutamatergic synapses are not known, and cellular phenotypes have not been investigated in Cntnap2 knockout neurons. Here we show that CNTNAP2 is present in dendritic spines, as well as axons and soma. Structured illumination superresolution microscopy reveals closer proximity to excitatory, rather than inhibitory synaptic markers. CNTNAP2 does not promote the formation of synapses and cultured neurons from Cntnap2 knockout mice do not show early defects in axon and dendrite outgrowth, suggesting that CNTNAP2 is not required at this stage. However, mature neurons from knockout mice show reduced spine density and levels of GluA1 subunits of AMPA receptors in spines. Unexpectedly, knockout neurons show large cytoplasmic aggregates of GluA1. Here we characterize, for the first time to our knowledge, synaptic phenotypes in Cntnap2 knockout neurons and reveal a novel role for CNTNAP2 in GluA1 trafficking. Taken together, our findings provide insight into the biological roles of CNTNAP2 and into the pathogenesis of CNTNAP2-associated neuropsychiatric disorders.
C1 [Varea, Olga; Martin-de-Saavedra, Maria Dolores; Kopeikina, Katherine J.; Schuermann, Britta; Fleming, Hunter J.; Fawcett-Patel, Jessica M.; Bach, Anthony; Penzes, Peter] Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USA.
[Penzes, Peter] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
[Jang, Seil; Kim, Eunjoon] Korea Adv Inst Sci & Technol, Dept Neurosci, Taejon 305701, South Korea.
[Kim, Eunjoon] Inst for Basic Sci Korea, Ctr Synapt Brain Dysfunct, Taejon 305701, South Korea.
[Peles, Elior] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel.
RP Penzes, P (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USA.
EM p-penzes@northwestern.edu
FU NIH National Institute of Mental Health [MH097216]; Institute for Basic
Science [IBS-R002-D1]; NIH Grant [NS50220, 1S10OD016342-01]; National
Cancer Institute Cancer Center Support Grant [P30 CA060553]
FX We thank Drs. Teng-Leong Chew and Joshua Zachary Rappoport for help with
SIM imaging. This work was supported by Grant MH097216 from the NIH
National Institute of Mental Health (to P.P.), IBS-R002-D1 from
Institute for Basic Science (to E.K.), German Research Foundation
Research Fellowship SCHU2710/1-1 (to B.S.), and NIH Grant NS50220 (to
E.P.). SIM imaging work was performed at the Northwestern University
Center for Advanced Microscopy, which is generously supported by
National Cancer Institute Cancer Center Support Grant P30 CA060553
awarded to the Robert H. Lurie Comprehensive Cancer Center. SIM imaging
was performed on a Nikon N-SIM system, purchased through the support of
NIH Grant 1S10OD016342-01.
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NR 42
TC 0
Z9 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 12
PY 2015
VL 112
IS 19
BP 6176
EP 6181
DI 10.1073/pnas.1423205112
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CH9XS
UT WOS:000354390600082
PM 25918374
ER
PT J
AU Xia, WL
Liu, YL
Jiao, JW
AF Xia, Wenlong
Liu, YanLi
Jiao, Jianwei
TI GRM7 Regulates Embryonic Neurogenesis via CREB and YAP
SO STEM CELL REPORTS
LA English
DT Article
ID METABOTROPIC GLUTAMATE RECEPTORS; CELL-PROLIFERATION; PROGENITOR
PROLIFERATION; CORTICAL DEVELOPMENT; PKC PHOSPHORYLATION; MAMMALIAN
BRAIN; DIFFERENTIATION; TRANSCRIPTION; BROMODEOXYURIDINE; BIOLOGY
AB Metabotropic glutamate receptor 7 (GRM7) has recently been identified to be associated with brain developmental defects, such as attention deficit hyperactivity disorder (ADHD) and autism. However, the function of GRM7 during brain development remains largely unknown. Here, we used gain-and loss-of-function strategies to investigate the role of GRM7 in early cortical development. We demonstrate that Grm7 knockdown increases neural progenitor cell (NPC) proliferation, decreases terminal mitosis and neuronal differentiation, and leads to abnormal neuronal morphology. GRM7 regulates the phosphorylation of cyclic AMP response element-binding protein (CREB) and the expression of Yes-associated protein (YAP) by directly interacting with CaM, which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development. These defects in neurogenesis are ameliorated by Grm7 overexpression, Creb knockdown, or Yap knockdown. Thus, our findings indicate that GRM7 signaling via CREB and YAP is necessary for neurogenesis in the brain.
C1 [Xia, Wenlong; Liu, YanLi; Jiao, Jianwei] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China.
[Xia, Wenlong] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China.
RP Jiao, JW (reprint author), Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China.
EM jwjiao@ioz.ac.cn
RI Jiao, Jianwei/I-1452-2013
OI Jiao, Jianwei/0000-0002-7893-0721
FU National Key Basic Research Program of China [2015CB964501,
2014CB964903]; Strategic Priority Research Program [XDA01020301];
National Science Foundation of China [31371477]
FX We thank Junhua Lv and Feng Liu for technical help. This work was
supported by grants from the National Key Basic Research Program of
China (2015CB964501 and 2014CB964903), Strategic Priority Research
Program (XDA01020301), and the National Science Foundation of China
(31371477).
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NR 36
TC 0
Z9 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2213-6711
J9 STEM CELL REP
JI Stem Cell Rep.
PD MAY 12
PY 2015
VL 4
IS 5
BP 795
EP 810
DI 10.1016/j.stemcr.2015.03.004
PG 16
WC Cell & Tissue Engineering; Cell Biology
SC Cell Biology
GA CI0DO
UT WOS:000354406400004
PM 25921811
ER
PT J
AU Rahbar, MH
Samms-Vaughan, M
Dickerson, AS
Loveland, KA
Ardjomand-Hessabi, M
Bressler, J
Shakespeare-Pellington, S
Grove, ML
Boerwinkle, E
AF Rahbar, Mohammad H.
Samms-Vaughan, Maureen
Dickerson, Aisha S.
Loveland, Katherine A.
Ardjomand-Hessabi, Manouchehr
Bressler, Jan
Shakespeare-Pellington, Sydonnie
Grove, Megan L.
Boerwinkle, Eric
TI Factors associated with blood lead concentrations of children in Jamaica
SO JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS
SUBSTANCES & ENVIRONMENTAL ENGINEERING
LA English
DT Article
DE Children; Jamaica; food; road traffic; lead; risk factors
ID AUTISM SPECTRUM DISORDERS; ARSENIC CONCENTRATIONS; DRINKING-WATER;
TRACE-ELEMENTS; HEAVY-METALS; MEXICO-CITY; EXPOSURE; FISH; CONSUMPTION;
SEDIMENTS
AB Lead is a heavy metal known to be detrimental to neurologic, physiologic, and behavioral health of children. Previous studies from Jamaica reported that mean lead levels in soil are four times that of lead levels in some other parts of the world. Other studies detected lead levels in fruits and root vegetables, which were grown in areas with lead contaminated soil. In this study, we investigate environmental factors associated with blood lead concentrations in Jamaican children. The participants in this study comprised 125 typically developing (TD) children (ages 2-8years) who served as controls in an age- and sex-matched case-control study that enrolled children from 2009-2012 in Jamaica. We administered a questionnaire to assess demographic and socioeconomic information as well as potential exposures to lead through food. Using General Linear Models (GLMs), we identified factors associated with blood lead concentrations in Jamaican children. The geometric mean blood lead concentration (GMBLC) in the sample of children in this study was 2.80 mu g dL(-1). In univariable GLM analyses, GMBLC was higher for children whose parents did not have education beyond high school compared to those whose parents had attained this level (3.00 mu g dL(-1) vs. 2.31 mu g dL(-1); P = 0.05), children living near a high traffic road compared to those who did not (3.43 mu g dL(-1) vs. 2.52 mu g dL(-1); P < 0.01), and children who reported eating ackee compared to those who did not eat this fruit (2.89 mu g dL(-1) vs. 1.65 mu g dL(-1); P < 0.05). In multivariable analysis, living near a high traffic road was identified as an independent risk factor for higher adjusted GMBLC (3.05 mu g dL(-1) vs. 2.19 mu g dL(-1); P = 0.01). While our findings indicate that GMBLC in Jamaican children has dropped by at least 62% during the past two decades, children living in Jamaica still have GMBLC that is twice that of children in more developed countries. In addition, we have identified significant risk factors for higher blood lead concentrations in Jamaican children. We believe increasing awareness among parents regarding these risk factors could potentially lead to a lower level of lead exposure in Jamaican children.
C1 [Rahbar, Mohammad H.; Boerwinkle, Eric] Univ Texas Sch Publ Hlth Houston, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA.
[Rahbar, Mohammad H.] Univ Texas Hlth Sci Ctr Houston, Sch Med, Dept Internal Med, Div Clin & Translat Sci, Houston, TX 77030 USA.
[Rahbar, Mohammad H.; Dickerson, Aisha S.; Ardjomand-Hessabi, Manouchehr] Univ Texas Hlth Sci Ctr Houston, Ctr Clin & Translat Sci, Biostat Epidemiol Res Design BERD Core, Houston, TX 77030 USA.
[Samms-Vaughan, Maureen; Shakespeare-Pellington, Sydonnie] Univ W Indies, Dept Child & Adolescent Hlth, Kingston 7, Jamaica.
[Loveland, Katherine A.] Univ Texas Hlth Sci Ctr Houston, Univ Texas Med Sch Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
[Bressler, Jan; Grove, Megan L.; Boerwinkle, Eric] Univ Texas Sch Publ Hlth Houston, Ctr Human Genet, Houston, TX USA.
RP Rahbar, MH (reprint author), Univ Texas Hlth Sci Ctr Houston, Ctr Clin & Translat Sci, Biostat Epidemiol Res Design BERD Core, 6410 Fannin St,UT Profess Bldg,Suite 1100-05, Houston, TX 77030 USA.
EM Mohammad.H.Rahbar@uth.tmc.edu
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development (NICHD); National Institutes of Health Fogarty International
Center (NIH-FIC) [R21HD057808]; National Institute of Environmental
Health Sciences (NIEHS) [R01ES022165];
Biostatistics/Epidemiology/Research Design (BERD) component of the
Center for Clinical and Translational Sciences (CCTS); NIH Centers for
Translational Science Award (NIH CTSA) grant [UL1 RR024148]; National
Center for Research Resources (NCRR); National Center for Advancing
Translational Sciences (NCATS) [UL1 TR000371]
FX This research is co-funded by the Eunice Kennedy Shriver National
Institute of Child Health and Human Development (NICHD) and the National
Institutes of Health Fogarty International Center (NIH-FIC) by a grant
(R21HD057808) as well as National Institute of Environmental Health
Sciences (NIEHS) by a grant (R01ES022165) awarded to University of Texas
Health Science Center at Houston. We also acknowledge the support
provided by the Biostatistics/Epidemiology/Research Design (BERD)
component of the Center for Clinical and Translational Sciences (CCTS)
for this project. CCTS is mainly funded by the NIH Centers for
Translational Science Award (NIH CTSA) grant (UL1 RR024148), awarded to
University of Texas Health Science Center at Houston in 2006 by the
National Center for Research Resources (NCRR) and its renewal (UL1
TR000371) by the National Center for Advancing Translational Sciences
(NCATS). The content is solely the responsibility of the authors and
does not necessarily represent the official views of the NICHD or the
NIH-FIC or NIEHS or the NCRR or the NCATS.
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NR 82
TC 0
Z9 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1093-4529
EI 1532-4117
J9 J ENVIRON SCI HEAL A
JI J. Environ. Sci. Health Part A-Toxic/Hazard. Subst. Environ. Eng.
PD MAY 12
PY 2015
VL 50
IS 6
BP 529
EP 539
DI 10.1080/10934529.2015.994932
PG 11
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA CF1PU
UT WOS:000352320600001
PM 25837555
ER
PT J
AU Gdalyahu, A
Lazaro, M
Penagarikano, O
Golshani, P
Trachtenberg, JT
Gescwind, DH
AF Gdalyahu, Amos
Lazaro, Maria
Penagarikano, Olga
Golshani, Peyman
Trachtenberg, Joshua T.
Gescwind, Daniel H.
TI The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2)
Stabilizes New Spines: An In Vivo Mouse Study
SO PLOS ONE
LA English
DT Article
ID STRUCTURAL PLASTICITY; LONG-TERM; EXPERIENCE; CORTEX; NEOCORTEX;
SYNAPSES; CONTACTIN-ASSOCIATED-PROTEIN-LIKE-2; IMPLICATE; DYNAMICS;
EPILEPSY
AB The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process. Indeed, we found that new dendritic spines in mice lacking CNTNAP2 were formed at normal rates, but failed to stabilize. Notably, rates of spine elimination were unaltered, suggesting a specific role for CNTNAP2 in stabilizing new synaptic circuitry.
C1 [Gdalyahu, Amos; Trachtenberg, Joshua T.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol,Brain Res Inst, Integrat Ctr Learning & Memory,Semel Inst Neurosc, Los Angeles, CA 90095 USA.
[Lazaro, Maria; Penagarikano, Olga; Golshani, Peyman; Gescwind, Daniel H.] Univ Calif Los Angeles, David Geffen Sch Med, Program Neurogenet & Neurobehav Genet, Dept Neurol,Semel Inst Neurosci & Behav, Los Angeles, CA 90095 USA.
RP Gdalyahu, A (reprint author), Tel Aviv Univ, Dept Neurobiol, IL-69978 Tel Aviv, Israel.
EM amos.gdalyahu@gmail.com
FU ACE Network [5RO1MH081754, RO1MH10027]
FX Funding: This work was supported by ACE Network grant 5RO1MH081754 and
the renewal RO1MH10027. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
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NR 31
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 7
PY 2015
VL 10
IS 5
AR e0125633
DI 10.1371/journal.pone.0125633
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CH7KF
UT WOS:000354214400040
PM 25951243
ER
PT J
AU Reiner, BC
Dunaevsky, A
AF Reiner, Benjamin C.
Dunaevsky, Anna
TI Deficit in Motor Training-Induced Clustering, but Not Stabilization, of
New Dendritic Spines in fmr1 Knock-Out Mice
SO PLOS ONE
LA English
DT Article
ID FRAGILE-X-SYNDROME; MENTAL-RETARDATION PROTEIN; LONG-TERM POTENTIATION;
SYNAPTIC PLASTICITY; MOUSE MODEL; MESSENGER-RNAS; CGG-REPEAT; AUTISM;
CORTEX; IDENTIFICATION
AB Fragile X Syndrome is the most common inherited intellectual disability, and Fragile X Syndrome patients often exhibit motor and learning deficits. It was previously shown that the fmr1 knock-out mice, a common mouse model of Fragile X Syndrome, recapitulates this motor learning deficit and that the deficit is associated with altered plasticity of dendritic spines. Here, we investigated the motor learning-induced turnover, stabilization and clustering of dendritic spines in the fmr1 knock-out mouse using a single forelimb reaching task and in vivo multiphoton imaging. We report that fmr1 knock-out mice have deficits in motor learning-induced changes in dendritic spine turnover and new dendritic spine clustering, but not the motor learning-induced long-term stabilization of new dendritic spines. These results suggest that a failure to establish the proper synaptic connections in both number and location, but not the stabilization of the connections that are formed, contributes to the motor learning deficit seen in the fmr1 knock-out mouse.
C1 [Reiner, Benjamin C.; Dunaevsky, Anna] Univ Nebraska, Med Ctr, Munroe Meyer Inst, Dept Dev Neurosci, Omaha, NE 68182 USA.
RP Dunaevsky, A (reprint author), Univ Nebraska, Med Ctr, Munroe Meyer Inst, Dept Dev Neurosci, Omaha, NE 68182 USA.
EM adunaevsky@unmc.edu
FU National Institute of Child Health and Human Development [R01 HD67218]
FX This work was supported by the National Institute of Child Health and
Human Development R01 HD67218 to A.D. The funder had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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NR 43
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 7
PY 2015
VL 10
IS 5
AR e0126572
DI 10.1371/journal.pone.0126572
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CH7KF
UT WOS:000354214400101
PM 25950728
ER
PT J
AU Serret, S
Thummler, S
Dor, E
Vesperini, S
Santos, A
Askenazy, F
AF Serret, Sylvie
Thuemmler, Susanne
Dor, Emmanuelle
Vesperini, Stephanie
Santos, Andreia
Askenazy, Florence
TI Lithium as a rescue therapy for regression and catatonia features in two
SHANK3 patients with autism spectrum disorder: case reports
SO BMC PSYCHIATRY
LA English
DT Article
DE Autism; SHANK3 gene; Lithium; Regression; Catatonia
AB Background: Phelan-Mc Dermid syndrome is a contiguous disorder resulting from 22q13.3 deletion implicating the SHANK3 gene. The typical phenotype includes neonatal hypotonia, moderate to severe intellectual disability, absent or delayed speech, minor dysmorphic features and autism or autistic-like behaviour. Recently, point mutations or micro-deletions of the SHANK3 gene have been identified, accompanied by a phenotype different from the initial clinically description in Phelan McDermid syndrome.
Case presentation: Here we present two case studies with similar psychiatric and genetic diagnosis as well as similar clinical history and evolution. The two patients were diagnosed with autism spectrum disorders in childhood and presented regression with catatonia features and behavioural disorders after a stressful event during adolescence. Interestingly, both patients presented mutation/ microdeletion of the SHANK3 gene, inducing a premature stop codon in exon 21. Different pharmacological treatments (antipsychotics, benzodiazepines, mood stabilizer drugs, antidepressants, and methylphenidate) failed to improve clinical symptoms and lead to multiple adverse events. In contrast, lithium therapy reversed clinical regression, stabilized behavioural symptoms and allowed patients to recover their pre-catatonia level of functioning, without significant side effects.
Conclusion: These cases support the hypothesis of a specific SHANK3 phenotype. This phenotype might be linked to catatonia-like deterioration for which lithium use could be an efficient treatment. Therefore, these cases provide an important contribution to the field of autism research, clinical genetics and possible pharmacological answers.
C1 [Serret, Sylvie; Thuemmler, Susanne; Dor, Emmanuelle; Vesperini, Stephanie; Santos, Andreia; Askenazy, Florence] Univ Nice Sophia Antipolis, CoBTek EA7276, Childrens Hosp Nice CHU Lenval, Univ Child & Adolescent Psychiat Dept,Autism Reso, F-06189 Nice, France.
RP Serret, S (reprint author), Univ Nice Sophia Antipolis, CoBTek EA7276, Childrens Hosp Nice CHU Lenval, Univ Child & Adolescent Psychiat Dept,Autism Reso, F-06189 Nice, France.
EM serret.s@pediatrie-chulenval-nice.fr
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 19
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 7
PY 2015
VL 15
AR 107
DI 10.1186/s12888-015-0490-1
PG 6
WC Psychiatry
SC Psychiatry
GA CH9JO
UT WOS:000354352100002
PM 25947967
ER
PT J
AU Migliavacca, E
Golzio, C
Mannik, K
Blumenthal, I
Oh, EC
Harewood, L
Kosmicki, JA
Loviglio, MN
Giannuzzi, G
Hippolyte, L
Maillard, AM
Alfaiz, AA
van Haelst, MM
Andrieux, J
Gusella, JF
Daly, MJ
Beckmann, JS
Jacquemont, S
Talkowski, ME
Katsanis, N
Reymond, A
AF Migliavacca, Eugenia
Golzio, Christelle
Maennik, Katrin
Blumenthal, Ian
Oh, Edwin C.
Harewood, Louise
Kosmicki, Jack A.
Loviglio, Maria Nicla
Giannuzzi, Giuliana
Hippolyte, Loyse
Maillard, Anne M.
Alfaiz, Ali Abdullah
van Haelst, Mieke M.
Andrieux, Joris
Gusella, James F.
Daly, Mark J.
Beckmann, Jacques S.
Jacquemont, Sebastien
Talkowski, Michael E.
Katsanis, Nicholas
Reymond, Alexandre
CA 16p11 2 European Consortium
TI A Potential Contributory Role for Ciliary Dysfunction in the 16p11.2 600
kb BP4-BP5 Pathology
SO AMERICAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID COPY NUMBER VARIATION; DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDER;
SPINAL MUSCULAR-ATROPHY; SPATIAL WORKING-MEMORY; JOUBERT-SYNDROME;
CHROMOSOME 16P11.2; PRIMARY CILIUM; CENTROSOMAL PROTEIN; SCHIZOPHRENIA
AB The 16p11.2 600 kb copy-number variants (CNVs) are associated with mirror phenotypes on BMI, head circumference, and brain volume and represent frequent genetic lesions in autism spectrum disorders (ASDs) and schizophrenia. Here we interrogated the transcriptome of individuals carrying reciprocal 16p11.2 CNVs. Transcript perturbations correlated with clinical endophenotypes and were enriched for genes associated with ASDs, abnormalities of head size, and ciliopathies. Ciliary gene expression was also perturbed in orthologous mouse models, raising the possibility that ciliary dysfunction contributes to 16p11.2 pathologies. In support of this hypothesis, we found structural ciliary defects in the CA1 hippocampal region of 16p11.2 duplication mice. Moreover, by using an established zebrafish model, we show genetic interaction between KCTD13, a key driver of the mirrored neuroanatomical phenotypes of the 16p11.2 CNV, and ciliopathy-associated genes. Overexpression of BBS7 rescues head size and neuroanatomical defects of kctd13 morphants, whereas suppression or overexpression of CEP290 rescues phenotypes induced by KCTD13 under-or overexpression, respectively. Our data suggest that dysregulation of ciliopathy genes contributes to the clinical phenotypes of these CNVs.
C1 [Migliavacca, Eugenia; Maennik, Katrin; Harewood, Louise; Loviglio, Maria Nicla; Giannuzzi, Giuliana; Alfaiz, Ali Abdullah; Reymond, Alexandre] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
[Migliavacca, Eugenia; Alfaiz, Ali Abdullah; Beckmann, Jacques S.] SIB, CH-1015 Lausanne, Switzerland.
[Golzio, Christelle; Oh, Edwin C.; Katsanis, Nicholas] Duke Univ, Ctr Human Dis Modeling, Durham, NC 27710 USA.
[Golzio, Christelle; Oh, Edwin C.; Katsanis, Nicholas] Duke Univ, Dept Cell Biol, Durham, NC 27710 USA.
[Maennik, Katrin] Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.
[Blumenthal, Ian; Gusella, James F.; Talkowski, Michael E.] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.
[Kosmicki, Jack A.; Daly, Mark J.] Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA.
[Kosmicki, Jack A.; Daly, Mark J.] Harvard Univ, Sch Med, Boston, MA 02114 USA.
[Kosmicki, Jack A.; Daly, Mark J.] Broad Inst Harvard & MIT, Cambridge Ctr 7, Program Med & Populat Genet, Cambridge, MA 02142 USA.
[Kosmicki, Jack A.; Daly, Mark J.] Broad Inst Harvard & MIT, Cambridge Ctr 7, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.
[Hippolyte, Loyse; Maillard, Anne M.; Beckmann, Jacques S.; Jacquemont, Sebastien] Lausanne Univ Hosp CHUV, Serv Med Genet, CH-1011 Lausanne, Switzerland.
[van Haelst, Mieke M.] Univ Med Ctr Utrecht, Dept Med Genet, NL-3508 AB Utrecht, Netherlands.
[Andrieux, Joris] CHRU Lille, Inst Genet Med, Hop Jeanne de Flandre, F-59037 Lille, France.
[Gusella, James F.; Talkowski, Michael E.] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA.
[Gusella, James F.; Talkowski, Michael E.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02114 USA.
[Beckmann, Jacques S.] Univ Lausanne, Dept Med Genet, CH-1011 Lausanne, Switzerland.
RP Katsanis, N (reprint author), Duke Univ, Ctr Human Dis Modeling, Durham, NC 27710 USA.
EM katsanis@cellbio.duke.edu; alexandre.reymond@unil.ch
FU Swiss Scientific Exchange NMS Program; Swiss National Science Foundation
(SNSF); Brain and Behavior Research Foundation; Saudi Arabian National
Guard Health Affairs; Simons Foundation [SFARI274424, SFARI239983,
SFARI238504, SFARI240021]; Swiss National Science Foundation
[31003A_160203]; SNSF [CRIS FN CRSII33-133044]; Leenaards Foundation
Prize; NIH [P50MH094260, MH095867]; Nancy Lurie Marks Family Foundation
FX We thank the members of the Lausanne Genomic Technologies Facility,
Patrick Meylan, and Alexandre Thiery for technical help. We are grateful
to all the families participating to the Simons Variation in Individuals
Project (Simons VIP), as well as to the Simons VIP working group. K.M.
was awarded a scholarship from the Swiss Scientific Exchange NMS
Program, S.J. is recipient of a Bursary Professor fellowship of the
Swiss National Science Foundation (SNSF), and C.G., E.C.O., and M.E.T.
are grantees of NARSAD Young Investigator Grants from the Brain and
Behavior Research Foundation. A. A. A. was awarded a scholarship from
the Saudi Arabian National Guard Health Affairs. This work is supported
by the Simons Foundation (grants SFARI274424 to A.R., SFARI239983 to
N.K., SFARI238504 to M.E.T., and SFARI240021 to J.F.G.), the Swiss
National Science Foundation (grant 31003A_160203 to A.R.), a specific
SNSF Sinergia grant (CRIS FN CRSII33-133044 to A.R.), the Leenaards
Foundation Prize (S.J. and A.R.), by NIH P50MH094260 (N.K.) and MH095867
(M.E.T.), and the Nancy Lurie Marks Family Foundation (J.F.G. and
M.E.T.). N.K. is a Distinguished Brumley Professor. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
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NR 86
TC 0
Z9 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0002-9297
EI 1537-6605
J9 AM J HUM GENET
JI Am. J. Hum. Genet.
PD MAY 7
PY 2015
VL 96
IS 5
BP 784
EP 796
DI 10.1016/j.ajhg.2015.04.002
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA CH7AZ
UT WOS:000354189300009
PM 25937446
ER
PT J
AU Barrer, L
Gimenez, G
AF Barrer, Laurence
Gimenez, Guy
TI First time description of dismantling phenomenon
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE countertransference; autistic disorder; dismantling; metapsychology;
defense mechanism
AB Dismantling is a complex psychic phenomenon, which is not easy to define, and little interest has been shown in the subject. The authors of this paper want to demonstrate that dismantling is the main defense mechanism in autism, bringing about de-consensus of senses. The effects perceived in a child with autistic disorder are passivity and lack of thought. The authors' purpose here is to define the dismantled state and reveal its underlying process. This paper will therefore describe for the first time in literature, the dismantling phenomenon and will submit a metapsychological approach of this defense mechanism.
C1 [Barrer, Laurence; Gimenez, Guy] Aix Marseille Univ, UFR Lettres & Sci Humaines, Dept Psychol, Lab Psychol Clin Langage & Subjectiv,EA 3278, F-13621 Aix En Provence, Bouches Du Rhon, France.
RP Barrer, L (reprint author), Aix Marseille Univ, UFR Lettres & Sci Humaines, Dept Psychol, Lab Psychol Clin Langage & Subjectiv,EA 3278, 29 Ave Robert Schumann, F-13621 Aix En Provence, Bouches Du Rhon, France.
EM lbarrer@free.fr
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NR 35
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD MAY 5
PY 2015
VL 6
AR 510
DI 10.3389/fpsyg.2015.00510
PG 5
WC Psychology, Multidisciplinary
SC Psychology
GA CI5PC
UT WOS:000354809100001
PM 25999871
ER
PT J
AU Clausi, S
Coricelli, G
Pisotta, I
Pavone, EF
Lauriola, M
Molinari, M
Leggio, M
AF Clausi, Silvia
Coricelli, Giorgio
Pisotta, Iolanda
Pavone, Enea Francesco
Lauriola, Marco
Molinari, Marco
Leggio, Maria
TI Cerebellar damage impairs the self-rating of regret feeling in a
gambling task
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE choice behavior; cortico-cerebellar circuits; emotion; gambling;
self-monitoring; social cognition; autism spectrum disorders;
alexithymia
ID DECISION-MAKING; ORBITOFRONTAL CORTEX; EMOTION; DISAPPOINTMENT; AUTISM;
BRAIN; SCHIZOPHRENIA; NEUROANATOMY; COGNITION; NETWORKS
AB Anatomical, clinical, and neuroimaging evidence implicates the cerebellum in processing emotions and feelings. Moreover recent studies showed a cerebellar involvement in pathologies such as autism, schizophrenia and alexithymia, in which emotional processing have been found altered. However, cerebellar function in the modulation of emotional responses remains debated. In this study, emotions that are involved directly in decision-making were examined in 15 patients (six males; age range 17-60 years) affected by cerebellar damage and 15 well matched healthy controls. We used a gambling task, in which subjects' choices and evaluation of outcomes with regard to their anticipated and actual emotional impact were analyzed. Emotions, such as regret and relief, were elicited, based on the outcome of the unselected gamble. Interestingly, despite their ability to avoid regret in subsequent choices, patients affected by cerebellar lesions were significantly impaired in evaluating the feeling of regret subjectively. These results demonstrate that the cerebellum is involved in conscious recognizing of negative feelings caused by the sense of self-responsibility for an incorrect decision.
C1 [Clausi, Silvia; Pisotta, Iolanda; Leggio, Maria] Univ Roma La Sapienza, Dept Psychol, I-00185 Rome, Italy.
[Clausi, Silvia; Leggio, Maria] IRCCS Santa Lucia Fdn, Ataxia Lab, Rome, Italy.
[Coricelli, Giorgio] Univ So Calif, Dept Econ, Los Angeles, CA 90089 USA.
[Pisotta, Iolanda; Molinari, Marco] IRCCS Santa Lucia Fdn, Neurol & Spinal Cord Injury Rehabil Dept A, Rome, Italy.
[Pavone, Enea Francesco] IRCCS Santa Lucia Fdn, Social & Cognit Neurosci Lab, Rome, Italy.
[Pavone, Enea Francesco] Braintrends Ltd, Appl Neurosci, Rome, Italy.
[Lauriola, Marco] Univ Roma La Sapienza, Dept Dev & Social Psychol, I-00185 Rome, Italy.
RP Leggio, M (reprint author), Univ Roma La Sapienza, Dept Psychol, Via Marsi 78, I-00185 Rome, Italy.
EM maria.leggio@uniroma1.it
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NR 51
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD MAY 5
PY 2015
VL 9
AR 113
DI 10.3389/fnbeh.2015.00113
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CI2IL
UT WOS:000354569700001
PM 25999829
ER
PT J
AU Fournet, N
Roulin, JL
Monnier, C
Atzeni, T
Cosnefroy, O
Le Gall, D
Roy, A
AF Fournet, Nathalie
Roulin, Jean-Luc
Monnier, Catherine
Atzeni, Thierry
Cosnefroy, Olivier
Le Gall, Didier
Roy, Arnaud
TI Multigroup confirmatory factor analysis and structural invariance with
age of the Behavior Rating Inventory of Executive Function
(BRIEF)-French version
SO CHILD NEUROPSYCHOLOGY
LA English
DT Article
DE Executive function; Multigroup confirmatory factor analysis;
Development; Measurement invariance; BRIEF
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; LATENT VARIABLE ANALYSIS;
WORKING-MEMORY; CHILDREN; VALIDITY; ADHD; CIRCUITS; DEFICITS; AUTISM;
SAMPLE
AB The parent and teacher forms of the French version of the Behavioral Rating Inventory of Executive Function (BRIEF) were used to evaluate executive function in everyday life in a large sample of healthy children (N=951) aged between 5 and 18.
Several psychometric methods were applied, with a view to providing clinicians with tools for score interpretation. The parent and teacher forms of the BRIEF were acceptably reliable. Demographic variables (such as age and gender) were found to influence the BRIEF scores. Confirmatory factor analysis was then used to test five competing models of the BRIEF's latent structure. Two of these models (a three-factor model and a two-factor model, both based on a nine-scale structure) had a good fit. However, structural invariance with age was only obtained with the two-factor model.
The French version of the BRIEF provides a useful measure of everyday executive function and can be recommended for use in clinical research and practice.
C1 [Fournet, Nathalie; Roulin, Jean-Luc] Univ Savoie, Lab Psychol & Neurocognit LPNC, F-73011 Chambery, France.
[Monnier, Catherine] Univ Montpellier 3, Lab Epsylon, F-34032 Montpellier 5, France.
[Atzeni, Thierry] Lab Psychol Sante & Qualite Vie, Bordeaux, France.
[Cosnefroy, Olivier] Univ Grenoble Alpes, Lab Sci & Educ, Grenoble 9, France.
[Le Gall, Didier; Roy, Arnaud] Univ Angers, LUNAM, UPRES EA 4638, Lab Psychol Pays Loire, Angers, France.
[Roy, Arnaud] CHU Nantes, Ctr Competence Nantais Neurofibromatose, Unite Pediat Troubles Apprentissage, Ctr Referent Langage, F-44035 Nantes 01, France.
RP Fournet, N (reprint author), Univ Savoie, LPNC, Dept Psychol, F-73011 Chambery, France.
EM nathalie.fournet@univ-savoie.fr
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NR 54
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0929-7049
EI 1744-4136
J9 CHILD NEUROPSYCHOL
JI Child Neuropsychol.
PD MAY 4
PY 2015
VL 21
IS 3
BP 379
EP 398
DI 10.1080/09297049.2014.906569
PG 20
WC Clinical Neurology
SC Neurosciences & Neurology
GA CI9SC
UT WOS:000355109100007
PM 24754365
ER
PT J
AU Fawkes, DB
Malow, BA
Weiss, SK
Reynolds, AM
Loh, A
Adkins, KW
Wofford, DD
Wyatt, AD
Goldman, SE
AF Fawkes, Diane B.
Malow, Beth A.
Weiss, Shelly K.
Reynolds, Ann M.
Loh, Alvin
Adkins, Karen W.
Wofford, Deborah D.
Wyatt, Amanda D.
Goldman, Suzanne E.
TI Conducting Actigraphy Research in Children With Neurodevelopmental
Disorders-A Practical Approach
SO BEHAVIORAL SLEEP MEDICINE
LA English
DT Article
ID PRACTICE PARAMETERS; WRIST ACTIGRAPHY; SLEEP DISORDERS; AUTISM;
ADOLESCENTS; INSOMNIA; SPECTRUM; UPDATE; HOME
AB The literature has been highly informative for when to use actigraphy and its validity in pediatric research. However, minimal literature exists on how to perform actigraphy, especially in special populations. We determined whether providing actigraphy training to parents and coordinators increased the nights of actigraphy data that could be scored. We compared two studies in children with autism spectrum disorders, one of which provided a basic level of training in a single-site trial and the other of which provided more detailed training to parents and coordinators in a multisite trial. There was an increase in scorable nights in the multisite trial containing a one-hour structured parent training session. Our results support the use of educational tools in clinical trials that use actigraphy.
C1 [Fawkes, Diane B.; Malow, Beth A.; Adkins, Karen W.; Wofford, Deborah D.; Wyatt, Amanda D.; Goldman, Suzanne E.] Vanderbilt Univ, Dept Neurol, Sleep Disorders Div, Sch Med, Nashville, TN 37232 USA.
[Malow, Beth A.; Goldman, Suzanne E.] Vanderbilt Univ, Vanderbilt Kennedy Ctr, Nashville, TN 37232 USA.
[Weiss, Shelly K.] Univ Toronto, Hosp Sick Children, Toronto, ON M5S 1A1, Canada.
[Reynolds, Ann M.] Univ Colorado Denver, Dept Pediat, Anschutz Med Campus, Aurora, CO USA.
[Reynolds, Ann M.] Univ Colorado, Sch Med, Aurora, CO USA.
[Loh, Alvin] Univ Toronto, Pediat, Toronto, ON, Canada.
[Loh, Alvin] Surrey Pl Ctr, Toronto, ON M5S 2C2, Canada.
RP Fawkes, DB (reprint author), Vanderbilt Univ, Dept Neurol, Sleep Disorders Div, 1161 21st Ave South,Room A-0118, Nashville, TN 37232 USA.
EM diane.b.fawkes@vanderbilt.edu
FU U.S. Department of Health and Human Services, Health Resources and
Services Administration, Maternal and Child Health Research Program [UA3
MC 11054]; Organization for Autism Research; CTSA from the National
Center for Advancing Translational Sciences [UL1TR000445]
FX The authors report no conflicts of interest or financial relationships
relevant to this article. This research was conducted as part of the
Autism Speaks Autism Treatment Network. Further support came from a
cooperative agreement (UA3 MC 11054) from the U.S. Department of Health
and Human Services, Health Resources and Services Administration,
Maternal and Child Health Research Program, to the Massachusetts General
Hospital. Additional support was provided by the Organization for Autism
Research and CTSA award No. UL1TR000445 from the National Center for
Advancing Translational Sciences. The views expressed in this
publication do not necessarily reflect the views of Autism Speaks, Inc.
Its contents are solely the responsibility of the authors and do not
necessarily represent official views of the National Center for
Advancing Translational Sciences or the National Institutes of Health.
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NR 30
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1540-2002
EI 1540-2010
J9 BEHAV SLEEP MED
JI Behav. Sleep Med.
PD MAY 4
PY 2015
VL 13
IS 3
BP 181
EP 196
DI 10.1080/15402002.2013.854245
PG 16
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CH0QR
UT WOS:000353727800002
PM 24669845
ER
PT J
AU Seigfried-Spellar, KC
O'Quinn, CL
Treadway, KN
AF Seigfried-Spellar, Kathryn C.
O'Quinn, Casey L.
Treadway, Kellin N.
TI Assessing the relationship between autistic traits and cyberdeviancy in
a sample of college students
SO BEHAVIOUR & INFORMATION TECHNOLOGY
LA English
DT Article
DE computer crime; autism; Asperger syndrome; hacking; cybercrime;
cyberbullying; personality
ID SYNDROME/HIGH-FUNCTIONING AUTISM; SPECTRUM QUOTIENT AQ;
ASPERGER-SYNDROME; COMPUTER; VALIDITY; BEHAVIOR
AB Case studies suggest a relationship between Asperger syndrome (AS) and computer hacking. The current study examined whether characteristics associated with AS were significantly related to hacking, cyberbullying, identity theft, and virus writing. Two hundred and ninety-six university undergraduate students completed an Internet-based anonymous survey measuring self-reported computer deviant behaviour and characteristics associated with AS (autism-spectrum quotient; AQ). Of the 296 university students, 179 (60%) engaged in some form of computer deviant behaviour, but only 2 (0.01%) yielded clinically significant scores according to the AQ. Contrary to the authors' expectations, hackers did not score higher on the AQ compared to non-computer hackers. However, virus writers, identity thieves, and cyberbullies scored higher on the AQ compared to their computer non-deviant counterparts. In addition, individuals who engaged in hacking, identity theft, cyberbullying, and virus writing scored higher on the AQ and reported poorer social skills, poorer communication, and poorer imagination compared to all other individuals engaging in computer deviant behaviours. Considerations for future research and study limitations are discussed.
C1 [Seigfried-Spellar, Kathryn C.; O'Quinn, Casey L.; Treadway, Kellin N.] Univ Alabama, Dept Criminal Justice, Tuscaloosa, AL 35487 USA.
RP Seigfried-Spellar, KC (reprint author), Univ Alabama, Dept Criminal Justice, 410 Farrah Hall,Box 870320 Mailing, Tuscaloosa, AL 35487 USA.
EM kseigspell@ua.edu
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NR 31
TC 0
Z9 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0144-929X
EI 1362-3001
J9 BEHAV INFORM TECHNOL
JI Behav. Inf. Technol.
PD MAY 4
PY 2015
VL 34
IS 5
BP 533
EP 542
DI 10.1080/0144929X.2014.978377
PG 10
WC Computer Science, Cybernetics; Ergonomics
SC Computer Science; Engineering
GA CD1EZ
UT WOS:000350818600009
ER
PT J
AU Clarke, CE
Dixon, GN
Holton, A
McKeever, BW
AF Clarke, Christopher E.
Dixon, Graham N.
Holton, Avery
McKeever, Brooke Weberling
TI Including "Evidentiary Balance" in News Media Coverage of Vaccine Risk
SO HEALTH COMMUNICATION
LA English
DT Article
ID UNCERTAINTY; INFORMATION; JOURNALISM; AUTISM; REPRESENTATIONS;
COMMUNICATION; PERCEPTIONS; CREDIBILITY; CONTROVERSY; SCIENTISTS
AB Journalists communicating risk-related uncertainty must accurately convey scientific evidence supporting particular conclusions. Scholars have explored how "balanced" coverage of opposing risk claims shapes uncertainty judgments. In situations where a preponderance of evidence points to a particular conclusion, balanced coverage reduces confidence in such a consensus and heightens uncertainty about whether a risk exists. Using the autism-vaccine controversy as a case study, we describe how journalists can cover multiple sides of an issue and provide insight into where the strength of evidence lies by focusing on "evidentiary balance." Our results suggest that evidentiary balance shapes perceived certainty that vaccines are safe, effective, and not linked to autism through the mediating role of a perception that scientists are divided about whether a link exists. Deference toward science, moreover, moderates these relationships under certain conditions. We discuss implications for journalism practice and risk communication.
C1 [Clarke, Christopher E.] George Mason Univ, Dept Commun, Fairfax, VA 20031 USA.
[Dixon, Graham N.] Washington State Univ, Murrow Coll Commun, Pullman, WA 99164 USA.
[Holton, Avery] Univ Utah, Dept Commun, Salt Lake City, UT 84112 USA.
[McKeever, Brooke Weberling] Univ S Carolina, Sch Journalism & Mass Commun, Columbia, SC 29208 USA.
RP Clarke, CE (reprint author), George Mason Univ, Dept Commun, 4400 Univ Dr,MS 3D6, Fairfax, VA 20031 USA.
EM cclark27@gmu.edu
CR Afifi WA, 2004, COMMUN THEOR, V14, P167, DOI 10.1111/j.1468-2885.2004.tb00310.x
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Holton A., 2011, ELECT J COMMUNICATIO, V21, P1
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NR 37
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1041-0236
EI 1532-7027
J9 HEALTH COMMUN
JI Health Commun.
PD MAY 4
PY 2015
VL 30
IS 5
BP 461
EP 472
DI 10.1080/10410236.2013.867006
PG 12
WC Communication; Health Policy & Services
SC Communication; Health Care Sciences & Services
GA CB5LC
UT WOS:000349667500005
PM 25010352
ER
PT J
AU Fernandez, MAF
Puentes, AA
AF Fernandez Fernandez, M. A.
Amado Puentes, A.
TI The importance of being careful with the concepts on autism spectrum
disorders
SO ANALES DE PEDIATRIA
LA Spanish
DT Letter
C1 [Fernandez Fernandez, M. A.] Inst Andaluz Neurol Pediat, Area Neurol Pediat, Seville, Spain.
[Amado Puentes, A.] Complejo Hosp Univ Vigo, Serv Pediat, Unidad Neurol Pediait, Vigo, Spain.
RP Fernandez, MAF (reprint author), Inst Andaluz Neurol Pediat, Area Neurol Pediat, Seville, Spain.
EM drlolo13@hotmail.com; amadopuentes@gmail.com
CR Alonso Canal L, 2014, AN PEDIAT BARC
CDC, 2012, MMWR SURVEILL SUMM, V61, P1
Mari-Bauset S, 2014, J CHILD NEUROL
Sponheim E, 2006, TIDSSKR NOR LAEGEFOR, V25, P1475
NR 4
TC 0
Z9 0
PU EDICIONES DOYMA S A
PI BARCELONA
PA TRAV DE GRACIA 17-21, 08021 BARCELONA, SPAIN
SN 1695-4033
EI 1696-4608
J9 AN PEDIATR
JI An. Pediatr.
PD MAY
PY 2015
VL 82
IS 5
BP 372
EP 372
DI 10.1016/j.anpedi.2014.09.016
PG 1
WC Pediatrics
SC Pediatrics
GA CI8ZF
UT WOS:000355059500017
PM 25510842
ER
PT J
AU Canal, LA
Zaragoza, CI
AF Alonso Canal, L.
Isasi Zaragoza, C.
TI Gluten-free, casein-free diet in autism spectrum disorders; different
perspectives
SO ANALES DE PEDIATRIA
LA Spanish
DT Letter
C1 [Alonso Canal, L.] Hosp San Rafael, Serv Gastroenterol Pediat, Madrid, Spain.
[Isasi Zaragoza, C.] Hosp Puerta Hierro Majadahonda, Serv Reumatol, Madrid, Spain.
RP Canal, LA (reprint author), Hosp San Rafael, Serv Gastroenterol Pediat, Madrid, Spain.
EM lauraalonso02@hotmail.com
CR de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
Pennesi CM, 2012, NUTR NEUROSCI, V15, P85, DOI 10.1179/1476830512Y.0000000003
Troncone R, 2011, J INTERN MED, V269, P582, DOI 10.1111/j.1365-2796.2011.02385.x
Vandenplas Yvan, 2014, Pediatr Gastroenterol Hepatol Nutr, V17, P1, DOI 10.5223/pghn.2014.17.1.1
NR 4
TC 0
Z9 0
PU EDICIONES DOYMA S A
PI BARCELONA
PA TRAV DE GRACIA 17-21, 08021 BARCELONA, SPAIN
SN 1695-4033
EI 1696-4608
J9 AN PEDIATR
JI An. Pediatr.
PD MAY
PY 2015
VL 82
IS 5
BP 373
EP 373
DI 10.1016/j.anpedi.2014.10.011
PG 1
WC Pediatrics
SC Pediatrics
GA CI8ZF
UT WOS:000355059500018
ER
PT J
AU Schwartzman, JS
Velloso, RD
D'Antino, MEF
Santos, S
AF Schwartzman, Jose Salomao
Velloso, Renata de Lima
Fama D'Antino, Maria Eloisa
Santos, Silvana
TI The eye-tracking of social stimuli in patients with Rett syndrome and
autism spectrum disorders: a pilot study
SO ARQUIVOS DE NEURO-PSIQUIATRIA
LA English
DT Article
DE Rett syndrome; autism spectrum disorders; social cognition; eye tracking
ID CHILDREN; MECP2; MUTATION; OXYTOCIN; FEATURES; REGION
AB Objective: To compare visual fixation at social stimuli in Rett syndrome (RT) and autism spectrum disorders (ASD) patients. Method: Visual fixation at social stimuli was analyzed in 14 RS female patients (age range 4-30 years), 11 ASD male patients (age range 4-20 years), and 17 children with typical development (TD). Patients were exposed to three different pictures (two of human faces and one with social and non-social stimuli) presented for 8 seconds each on the screen of a computer attached to an eye-tracker equipment. Results: Percentage of visual fixation at social stimuli was significantly higher in the RS group compared to ASD and even to TD groups. Conclusion: Visual fixation at social stimuli seems to be one more endophenotype making RS to be very different from ASD.
C1 [Schwartzman, Jose Salomao; Fama D'Antino, Maria Eloisa] Univ Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, SP, Brazil.
[Velloso, Renata de Lima] Univ Presbiteriana Mackenzie, Clin Transtornos Espectro Autismo, Sao Paulo, SP, Brazil.
[Santos, Silvana] Assoc Brasileira Sindrome Rett Sao Paulo Abre Te, Div Informacao & Pesquisa, Sao Paulo, SP, Brazil.
RP Schwartzman, JS (reprint author), Rua Franca Pinto 941, BR-04016034 Sao Paulo, SP, Brazil.
EM josess@terra.com.br
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Schwartzman JS, 2000, TEMAS DESENVOLV, V9, P5
Takahashi Satoru, 2014, No To Hattatsu, V46, P117
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Zhao Y, 2014, BMC MED GENET, V15, DOI 10.1186/1471-2350-15-24
NR 23
TC 0
Z9 0
PU ASSOC ARQUIVOS NEURO- PSIQUIATRIA
PI SAO PAULO SP
PA PR AMADEU AMARAL 47/33, 01327-010 SAO PAULO SP, BRAZIL
SN 0004-282X
EI 1678-4227
J9 ARQ NEURO-PSIQUIAT
JI Arq. Neuro-Psiquiatr.
PD MAY
PY 2015
VL 73
IS 5
BP 402
EP 407
DI 10.1590/0004-282X20150033
PG 6
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CJ2KL
UT WOS:000355313200006
PM 26017205
ER
PT J
AU Lee, PF
Thomas, RE
Lee, PA
AF Lee, Patrick F.
Thomas, Roger E.
Lee, Patricia A.
TI Approach to autism spectrum disorder Using the new DSM-V diagnostic
criteria and the CanMEDS-FM framework
SO CANADIAN FAMILY PHYSICIAN
LA English
DT Review
ID CHILDREN
AB Objective To review the diagnostic criteria for autism spectrum disorder (ASD) from the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V), and to develop an approach to managing ASD using the CanMEDS-Family Medicine (CanMEDS-FM) framework.
Sources of information The DSM-V from the American Psychiatric Association, published in May 2013, provides new diagnostic criteria for ASD. The College of Family Physicians of Canada's CanMEDS-FM framework provides a blueprint that can guide the complex management of ASD. We used data from the Centers for Disease Control and Prevention to determine the prevalence of ASD, and we used the comprehensive systematic review and meta-analysis completed by the UK National Institute for Health and Care Excellence for their guidelines on ASD to assess the evidence for more than 100 interventions.
Main message The prevalence of ASD was 1 in 88 in 2008 in the United States according to data from the Centers for Disease Control and Prevention. The ASD classification in the fourth edition of the DSM included autism, Asperger syndrome, pervasive developmental disorder, and childhood disintegrative disorder. The new DSM-V revision incorporates all these disorders into one ASD umbrella term with different severity levels. The management of ASD is complex and requires a multidisciplinary team effort and continuity of care. The CanMEDS-FM roles provide a framework for management.
Conclusion Family physicians are the key leaders of the multidisciplinary care team for ASD, and the CanMEDS-FM framework provides a comprehensive guide to help manage a child with ASD and to help the child's family.
C1 [Lee, Patrick F.; Thomas, Roger E.] Univ Calgary, Family Med, Calgary, AB T2N 1N4, Canada.
[Lee, Patrick F.; Thomas, Roger E.] Univ Calgary, Fac Med, Calgary, AB T2N 1N4, Canada.
[Lee, Patricia A.] Univ Calgary, Emergency Med Residency Program, Calgary, AB T2N 1N4, Canada.
RP Lee, PF (reprint author), Univ Calgary, Family Med, Calgary, AB T2N 1N4, Canada.
EM pflee@ucalgary.ca
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
[Anonymous], 2012, MMWR SURVEILL SUMM, V61, P1
Barton ML, 2012, J AUTISM DEV DISORD, V42, P1165, DOI 10.1007/s10803-011-1343-5
Canada Revenue Agency [website], 2015, REG DIS SAV PLAN RDS
Centers for Disease Control and Prevention, 2012, DAT STAT
GILLBERG C, 1987, J AUTISM DEV DISORD, V17, P273, DOI 10.1007/BF01495061
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NR 12
TC 0
Z9 0
PU COLL FAMILY PHYSICIANS CANADA
PI MISSISSAUGA
PA 2630 SKYMARK AVE, MISSISSAUGA, ONTARIO L4W 5A4, CANADA
SN 0008-350X
EI 1715-5258
J9 CAN FAM PHYSICIAN
JI Can. Fam. Phys.
PD MAY
PY 2015
VL 61
IS 5
BP 421
EP 424
PG 4
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CJ1PF
UT WOS:000355255300010
ER
PT J
AU Szyf, M
AF Szyf, Moshe
TI Epigenetics, a key for unlocking complex CNS disorders? Therapeutic
implications
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE DNA methylation; Epigenetics; Histone deacetylase (HDAC) inhibitors;
Early life adversity; Alzheimer disease; Schizophrenia; Epilepsy;
Valproic acid; S-adenosylmethionine (SAM); Epigenetic therapy
ID AUTISM SPECTRUM DISORDERS; EARLY-LIFE STRESS; FAMILIAL
ALZHEIMERS-DISEASE; COPY NUMBER VARIATION; DNA METHYLTRANSFERASES
DNMT3A; HISTONE DEACETYLASE COMPLEX; REGULATES MEMORY FORMATION;
RUBINSTEIN-TAYBI-SYNDROME; PITUITARY-ADRENAL AXIS; GENE-EXPRESSION
AB Aberrant changes in gene function are believed to be involved in a wide spectrum of human disease including behavioral, cognitive and neurodegenerative pathologies. Most of the attention in last few decades have focused on changes in gene sequence as a cause of gene dysfunction leading to disease and mental health disorders. Germ line mutations or other alterations in the sequence of DNA that associate with different behavioral and neurological pathologies have been identified. However, sequence alterations explain only a small fraction of the cases. In addition there is evidence for "gene-environment" interactions in the brain suggesting mechanisms that alter gene function and the phenotype through environmental exposure. Genes are programmed by "epigenetic" mechanisms such as chromatin structure, chromatin modification and DNA methylation. These mechanisms confer on similar sequences different identities during cellular differentiation. Epigenetic differences are proposed to be involved in differentiating gene function in response to different environmental contexts and could result in alterations in functional gene networks that lead to brain disease. Epigenetic markers could serve important biomarkers in brain and behavioral diseases. Moreover, epigenetic processes are potentially reversible pointing to epigenetic therapeutics in psychotherapy. (C) 2015 Published by Elsevier B.V.
C1 McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 1Y5, Canada.
RP Szyf, M (reprint author), McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 1Y5, Canada.
EM moshe.szyf@mcgill.ca
FU Canadian Institute for Health Research
FX This paper was funded by the Canadian Institute for Health Research and
there is no commercial interest.
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NR 245
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD MAY
PY 2015
VL 25
IS 5
SI SI
BP 682
EP 702
DI 10.1016/j.euroneuro.2014.01.009
PG 21
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CI8WO
UT WOS:000355052600005
PM 24857313
ER
PT J
AU Jedrzejewska-Szczerska, M
Karpienko, K
Landowska, A
AF Jedrzejewska-Szczerska, Malgorzata
Karpienko, Katarzyna
Landowska, Agnieszka
TI System supporting behavioral therapy for children with autism
SO JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
LA English
DT Article
DE Autism spectrum disorder; biomedical sensors; physiological parameters;
sensor network
ID HYPERVENTILATION SYNDROME; DISORDER; SENSORS; STRESS
AB In this paper, a system supporting behavioral therapy for autistic children is presented. The system consists of sensors network, base station and a brooch indicating person's emotional states. The system can be used to measure values of physiological parameters that are associated with changes in the emotional state. In the future, it can be useful to inform the autistic child and the therapist about the emotional state of the interlocutor objectively, on the basis of performed measurements. The selected physiological parameters were chosen during the experiment which was designed and conducted by authors. In this experiment, a group of volunteers under controlled conditions was exposed to a stressful situation caused by the picture or sound. For each of the volunteers, a set of physiological parameters, was recorded, including: skin conductance, heart rate, peripheral temperature, respiration rate and electromyography. The bio-statistical analysis allowed us to discern the proper physiological parameters that are most associated to changes due to emotional state of a patient, such as: skin conductance, temperatures and respiration rate. This allowed us to design electronic sensors network for supporting behavioral therapy for children with autism.
C1 [Jedrzejewska-Szczerska, Malgorzata] Gdansk Univ Technol, Fac Elect Telecommun & Informat, Dept Metrol & Optoelect, PL-80233 Gdansk, Poland.
[Karpienko, Katarzyna; Landowska, Agnieszka] Gdansk Univ Technol, Fac Elect Telecommun & Informat, Dept Software Engn, PL-80233 Gdansk, Poland.
RP Karpienko, K (reprint author), Gdansk Univ Technol, Fac Elect Telecommun & Informat, Dept Software Engn, Gabriela Narutowicza St 11-12, PL-80233 Gdansk, Poland.
EM k.karpienko@pro.wp.pl
FU Foundation for Polish Science [48/UD/SKILLS/2014]; National Centre for
Research and Development, Poland; DS Programs of the Faculty of
Electronics, Telecommunications and Informatics, Gdansk University of
Technology; European Cooperation in Science and Technology (COST) Action
[TD1309]
FX This study was partially supported by the Foundation for Polish Science
under grant No. 48/UD/SKILLS/2014 and the National Centre for Research
and Development, Poland under grant titled: "Automated therapy
monitoring for children with developmental disorders of autism
spectrum", as well as DS Programs of the Faculty of Electronics,
Telecommunications and Informatics, Gdansk University of Technology, and
European Cooperation in Science and Technology (COST) Action TD1309.
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PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 1793-5458
EI 1793-7205
J9 J INNOV OPT HEAL SCI
JI J. Innov. Opt. Health Sci.
PD MAY
PY 2015
VL 8
IS 3
SI SI
AR 1541008
DI 10.1142/S1793545815410084
PG 8
WC Optics; Radiology, Nuclear Medicine & Medical Imaging
SC Optics; Radiology, Nuclear Medicine & Medical Imaging
GA CJ3JQ
UT WOS:000355379600009
ER
PT J
AU Wang, KS
Tonarelli, S
Luo, XG
Wang, L
Su, BD
Zuo, LJ
Mao, CX
Rubin, L
Briones, D
Xu, C
AF Wang, Ke-Sheng
Tonarelli, Silvina
Luo, Xingguang
Wang, Liang
Su, Brenda
Zuo, Lingjun
Mao, ChunXiang
Rubin, Lewis
Briones, David
Xu, Chun
TI Polymorphisms within ASTN2 gene are associated with age at onset of
Alzheimer's disease
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Article
DE Alzheimer's disease; Genome-wide association; Age of onset; ASTN2;
Logrank test; Single-nucleotide polymorphisms
ID GENOME-WIDE ASSOCIATION; OF-ONSET; LOCI; SCHIZOPHRENIA; LINKAGE; NUMBER;
PREVALENCE; DISORDER; SPECTRUM; FAMILY
AB Alzheimer's disease (AD) is a multifactorial neurological condition associated with genetic profiles that are still not completely understood. We performed a family-based low-density genome-wide association analysis of age at onset (AAO) in AD (244 patients and their relatives) using Illumina 6 K single-nucleotide polymorphisms (SNPs) panel and the FBAT-logrank statistic. We observed 10 SNPs associated with AAO in AD with p < 2 x 10(-3). The most significant hit within a known gene, the neuronal protein astrotactin 2 (ASTN2), was SNP rs1334071 (p = 8.74 x 10(-4)). ASTN2 has been implicated in several neuropsychiatric disorders, including cognitive disorders, autism and schizophrenia. We then conducted a replication study focusing on ASTN2 gene in a Canadian sample of 791 AD patients and 782 controls using the logrank test. Five ASTN2 SNPs (highest association is rs16933774 with p = 0.0053) showed associations with AAO in this Canadian sample (p < 0.05). Furthermore, Kaplan-Meier survival analysis of SNP rs16933774 showed that the AAO of AD in individuals heterozygous for AG genotype of rs16933774 (median of AAO = 68.5 years) was approximately 4.5 years earlier than those individuals having the AA genotype (median of AAO = 73 years). In conclusion, a significant association of ASTN2 genetic variants with AAO of AD in two independent samples demonstrates a role for ASTN2 in the pathogenesis of AD. Future functional studies of this gene may help to characterize the genetic architecture of the AAO of AD. Genetic factors in AAO may be a critical factor for early AD intervention and prevention efforts.
C1 [Wang, Ke-Sheng; Wang, Liang] E Tennessee State Univ, Coll Publ Hlth, Dept Biostat & Epidemiol, Johnson City, TN USA.
[Tonarelli, Silvina; Briones, David] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Dept Psychiat, El Paso, TX USA.
[Luo, Xingguang; Zuo, Lingjun] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
[Su, Brenda] Harbin Med Univ, Coll Bioinformat Sci, Harbin, HeiLongJing, Peoples R China.
[Su, Brenda] Harbin Med Univ, Coll Technol, Harbin, HeiLongJing, Peoples R China.
[Mao, ChunXiang; Rubin, Lewis; Xu, Chun] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Dept Pediat, El Paso, TX 79905 USA.
RP Xu, C (reprint author), Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Dept Pediat, El Paso, TX 79905 USA.
EM chun.xu@ttuhsc.edu
FU National Institute on Drug Abuse (NIDA) [K01 DA029643]; National
Institute on Alcohol Abuse and Alcoholism (NIAAA) [R21 AA021380, R21
AA020319]; National Alliance for Research on Schizophrenia and
Depression (NARSAD) Award [17616]; ABMRF/The Foundation for Alcohol
Research; Division of Neuroscience, NIA; Genetic Consortium for
Late-Onset Alzheimer's Disease as part of the Division of Neuroscience,
NIA
FX This work was supported in part by National Institute on Drug Abuse
(NIDA) grant K01 DA029643, National Institute on Alcohol Abuse and
Alcoholism (NIAAA) grants R21 AA021380 and R21 AA020319, the National
Alliance for Research on Schizophrenia and Depression (NARSAD) Award
17616 (L.Z.) and ABMRF/The Foundation for Alcohol Research (L.Z.). We
acknowledge the NIH GWAS Data Repository, the Contributing
Investigator(s) who contributed the phenotype data and DNA samples from
his/her original study, and the primary funding organization that
supported the contributing study "National Institute on Aging (NIA)
Late-Onset Alzheimer's Disease Genetics Initiative: The Multiplex Family
Study". The NIA dataset used for analyses described in this manuscript
was obtained from dbGaP at
http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs0
00160.v1.p1 through dbGaP accession number: phs000160.v1.p1. Funding
support for the "Genetic Consortium for Late-Onset Alzheimer's Disease"
was provided through the Division of Neuroscience, NIA. The Genetic
Consortium for Late-Onset Alzheimer's Disease includes a genome-wide
association study funded as part of the Division of Neuroscience, NIA.
Assistance with phenotype harmonization and genotype cleaning, as well
as with general study coordination, was provided by Genetic Consortium
for Late-Onset Alzheimer's Disease. We also acknowledge the NIH GWAS
Data Repository, the Contributing Investigator(s) who contributed the
phenotype data and DNA samples from his/her original study and the
primary funding organization that supported the contributing study
"Multi-Site Collaborative Study for Genotype-Phenotype Associations in
Alzheimer's disease and longitudinal follow-up of Genotype-Phenotype
Associations in Alzheimer's disease and Neuroimaging component of
Genotype-Phenotype Associations in Alzheimer's disease". The genotypic
and associated phenotypic data used in the study, "Multi-Site
Collaborative Study for Genotype-Phenotype Associations in Alzheimer's
Disease (GenADA)" were provided by the GlaxoSmithKline, R&D Limited. The
datasets used for analyses described in this manuscript were obtained
from dbGaP at http://www.ncbi.nlm.nih.gov/gap through dbGaP accession
number phs000219.v1.p1.
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NR 33
TC 0
Z9 0
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD MAY
PY 2015
VL 122
IS 5
BP 701
EP 708
DI 10.1007/s00702-014-1306-z
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CJ2WD
UT WOS:000355344500009
PM 25410587
ER
PT J
AU Lukic, A
Uphill, J
Brown, CA
Beck, J
Poulter, M
Campbell, T
Adamson, G
Hummerich, H
Whitfield, J
Ponto, C
Zerr, I
Lloyd, SE
Collinge, J
Mead, S
AF Lukic, Ana
Uphill, James
Brown, Craig A.
Beck, John
Poulter, Mark
Campbell, Tracy
Adamson, Gary
Hummerich, Holger
Whitfield, Jerome
Ponto, Claudia
Zerr, Inga
Lloyd, Sarah E.
Collinge, John
Mead, Simon
TI Rare structural genetic variation in human prion diseases
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE Prion; CNV; CJD; Kuru; GWAS
ID CREUTZFELDT-JAKOB-DISEASE; GENOME-WIDE ASSOCIATION; RISK-FACTORS;
VARIANT; KURU; PRNP; MUTATIONS; GENOTYPE; SCRAPIE; 16P11.2
AB Prion diseases are a diverse group of neurodegenerative conditions, caused by the templated misfolding of prion protein. Aside from the strong genetic risk conferred by multiple variants of the prion protein gene (PRNP), several other variants have been suggested to confer risk in the most common type, sporadic Creutzfeldt-Jakob disease (sCJD) or in the acquired prion diseases. Large and rare copy number variants (CNVs) are known to confer risk in several related disorders including Alzheimer's disease (at APP), schizophrenia, epilepsy, mental retardation, and autism. Here, we report the first genome-wide analysis for CNV-associated risk using data derived from a recent international collaborative association study in sCJD (n = 1147 after quality control) and publicly available controls (n = 5427). We also investigated UK patients with variant Creutzfeldt-Jakob disease (n = 114) and elderly women from the Eastern Highlands of Papua New Guinea who proved highly resistant to the epidemic prion disease kuru, who were compared with healthy young Fore population controls (n = 395). There were no statistically significant alterations in the burden of CNVs >100, >500, or >1000 kb, duplications, or deletions in any disease group or geographic region. After correction for multiple testing, no statistically significant associations were found. A UK blood service control sample showed a duplication CNV that overlapped PRNP, but these were not found in prion disease. Heterozygous deletions of a 30 region of the PARK2 gene were found in 3 sCJD patients and no controls (p = 0.001, uncorrected). A cell-based prion infection assay did not provide supportive evidence for a role for PARK2 in prion disease susceptibility. These data are consistent with a modest impact of CNVs on risk of late-onset neurologic conditions and suggest that, unlike APP, PRNP duplication is not a causal high-risk mutation. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Lukic, Ana; Uphill, James; Brown, Craig A.; Beck, John; Poulter, Mark; Campbell, Tracy; Adamson, Gary; Hummerich, Holger; Whitfield, Jerome; Lloyd, Sarah E.; Collinge, John; Mead, Simon] UCL Inst Neurol, MRC Prion Unit, London WC1N 3BG, England.
[Ponto, Claudia; Zerr, Inga] Univ Gottingen, Dept Neurol, Gottingen, Germany.
[Ponto, Claudia; Zerr, Inga] German Ctr Neurodegenrat Dis DZNE, Gottingen, Germany.
RP Mead, S (reprint author), UCL Inst Neurol, MRC Prion Unit, Queen Sq, London WC1N 3BG, England.
EM s.mead@prion.ucl.ac.uk
FU Medical Research Council; Department of Health (England); Biomedical
Research Centre, University College London Hospitals NHS Trust; Robert
Koch-Institute through funds of the Federal Ministry of Health
[1369-341]
FX The authors are grateful for advice on statistical genetics from
Professor David Balding and Vincent Plagnol from UCL. This study was
funded by the Medical Research Council. Many patients were recruited by
the National Prion Monitoring Cohort study which was funded by the
Department of Health (England) and subsequently the Biomedical Research
Centre, University College London Hospitals NHS Trust. In Germany, the
study was funded by the Robert Koch-Institute through funds of the
Federal Ministry of Health (grant no. 1369-341).
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NR 39
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4580
EI 1558-1497
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD MAY
PY 2015
VL 36
IS 5
BP 2004
EP U20
DI 10.1016/j.neurobiolaging.2015.01.011
PG 8
WC Geriatrics & Gerontology; Neurosciences
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA CI9PA
UT WOS:000355100900021
ER
PT J
AU Nomi, JS
Uddin, LQ
AF Nomi, Jason S.
Uddin, Lucina Q.
TI Face processing in autism spectrum disorders: From brain regions to
brain networks
SO NEUROPSYCHOLOGIA
LA English
DT Review
DE Autism; Faces; fMRI; Connectivity; Social cognition; Eye gaze
ID HIGH-FUNCTIONING AUTISM; SUPERIOR TEMPORAL SULCUS; VOXEL
PATTERN-ANALYSIS; HUMAN NEURAL SYSTEM; SOCIAL BRAIN; TYPICAL
DEVELOPMENT; FACIAL EXPRESSIONS; ASPERGER-SYNDROME; FUSIFORM GYRUS; EYE
GAZE
AB Autism spectrum disorder (ASD) is characterized by reduced attention to social stimuli including the human face. This hypo-responsiveness to stimuli that are engaging to typically developing individuals may result from dysfunctioning motivation, reward, and attention systems in the brain. Here we review an emerging neuroimaging literature that emphasizes a shift from focusing on hypo-activation of isolated brain regions such as the fusiform gyms, amygdala, and superior temporal sulcus in ASD to a more holistic approach to understanding face perception as a process supported by distributed cortical and subcortical brain networks. We summarize evidence for atypical activation patterns within brain networks that may contribute to social deficits characteristic of the disorder. We conclude by pointing to gaps in the literature and future directions that will continue to shed light on aspects of face processing in autism that are still under-examined. In particular, we highlight the need for more developmental studies and studies examining ecologically valid and naturalistic social stimuli. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Nomi, Jason S.; Uddin, Lucina Q.] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
[Uddin, Lucina Q.] Univ Miami, Miller Sch Med, Neurosci Program, Miami, FL 33136 USA.
RP Nomi, JS (reprint author), Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA.
EM jxn131@miami.edu; l.uddin@miami.edu
FU National Institute of Mental Health Career Development Award
[K01MH092288]; International Society for Autism Research; NARSAD Young
Investigator Award
FX This work was supported by a National Institute of Mental Health Career
Development Award (K01MH092288), a Slifka/Ritvo Innovation in Autism
Research Award from the International Society for Autism Research, and a
NARSAD Young Investigator Award to LQU. The content is solely the
responsibility of the authors and does not necessarily represent the
official views of the NIMH or the NIH.
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NR 200
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3932
EI 1873-3514
J9 NEUROPSYCHOLOGIA
JI Neuropsychologia
PD MAY
PY 2015
VL 71
BP 201
EP 216
DI 10.1016/j.neuropsychologia.2015.03.029
PG 16
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA CI8PR
UT WOS:000355034700022
ER
PT J
AU Lal, D
Ruppert, AK
Trucks, H
Schulz, H
de Kovel, CG
Trenite, DKN
Sonsma, ACM
Koeleman, BP
Lindhout, D
Weber, YG
Lerche, H
Kapser, C
Schankin, CJ
Kunz, WS
Surges, R
Elger, CE
Gaus, V
Schmitz, B
Helbig, I
Muhle, H
Stephani, U
Klein, KM
Rosenow, F
Neubauer, BA
Reinthaler, EM
Zimprich, F
Feucht, M
Moller, RS
Hjalgrim, H
De Jonghe, P
Suls, A
Lieb, W
Franke, A
Strauch, K
Gieger, C
Schurmann, C
Schminke, U
Nurnberg, P
Sander, T
AF Lal, Dennis
Ruppert, Ann-Kathrin
Trucks, Holger
Schulz, Herbert
de Kovel, Carolien G.
Trenite, Dorothee Kasteleijn-Nolst
Sonsma, Anja C. M.
Koeleman, Bobby P.
Lindhout, Dick
Weber, Yvonne G.
Lerche, Holger
Kapser, Claudia
Schankin, Christoph J.
Kunz, Wolfram S.
Surges, Rainer
Elger, Christian E.
Gaus, Verena
Schmitz, Bettina
Helbig, Ingo
Muhle, Hiltrud
Stephani, Ulrich
Klein, Karl M.
Rosenow, Felix
Neubauer, Bernd A.
Reinthaler, Eva M.
Zimprich, Fritz
Feucht, Martha
Moller, Rikke S.
Hjalgrim, Helle
De Jonghe, Peter
Suls, Arvid
Lieb, Wolfgang
Franke, Andre
Strauch, Konstantin
Gieger, Christian
Schurmann, Claudia
Schminke, Ulf
Nuernberg, Peter
Sander, Thomas
CA EPICURE Consortium
TI Burden Analysis of Rare Microdeletions Suggests a Strong Impact of
Neurodevelopmental Genes in Genetic Generalised Epilepsies
SO PLOS GENETICS
LA English
DT Article
ID AUTISM SPECTRUM DISORDER; COPY NUMBER VARIANTS; GENOME-WIDE ASSOCIATION;
OF-FUNCTION MUTATIONS; EPILEPTIC ENCEPHALOPATHY; DEVELOPMENTAL DELAY;
INTELLECTUAL DISABILITY; 15Q13.3 MICRODELETIONS; 16P13.11 PREDISPOSE;
COMMON EPILEPSIES
AB Genetic generalised epilepsy (GGE) is the most common form of genetic epilepsy, accounting for 20% of all epilepsies. Genomic copy number variations (CNVs) constitute important genetic risk factors of common GGE syndromes. In our present genome-wide burden analysis, large (>= 400 kb) and rare (<1%) autosomal microdeletions with high calling confidence (>= 200 markers) were assessed by the Affymetrix SNP 6.0 array in European case-control cohorts of 1,366 GGE patients and 5,234 ancestry-matched controls. We aimed to: 1) assess the microdeletion burden in common GGE syndromes, 2) estimate the relative contribution of recurrent microdeletions at genomic rearrangement hotspots and non-recurrent microdeletions, and 3) identify potential candidate genes for GGE. We found a significant excess of microdeletions in 7.3% of GGE patients compared to 4.0% in controls (P = 1.8 x 10-7; OR = 1.9). Recurrent microdeletions at seven known genomic hotspots accounted for 36.9% of all microdeletions identified in the GGE cohort and showed a 7.5-fold increased burden (P = 2.6 x 10(-17)) relative to controls. Microdeletions affecting either a gene previously implicated in neurodevelopmental disorders (P = 8.0 x 10(-18), OR = 4.6) or an evolutionarily conserved brain-expressed gene related to autism spectrum disorder (P = 1.3 x 10(-12), OR = 4.1) were significantly enriched in the GGE patients. Microdeletions found only in GGE patients harboured a high proportion of genes previously associated with epilepsy and neuropsychiatric disorders (NRXN1, RBFOX1, PCDH7, KCNA2, EPM2A, RORB, PLCB1). Our results demonstrate that the significantly increased burden of large and rare microdeletions in GGE patients is largely confined to recurrent hotspot microdeletions and microdeletions affecting neurodevelopmental genes, suggesting a strong impact of fundamental neurodevelopmental processes in the pathogenesis of common GGE syndromes.
C1 [Lal, Dennis; Ruppert, Ann-Kathrin; Trucks, Holger; Schulz, Herbert; Nuernberg, Peter] Univ Cologne, CCG, D-50931 Cologne, Germany.
[Lal, Dennis; Nuernberg, Peter] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50931 Cologne, Germany.
[Lal, Dennis; Neubauer, Bernd A.] Univ Med Ctr Giessen & Marburg, Dept Neuropediat, Giessen, Germany.
[Lal, Dennis; Ruppert, Ann-Kathrin; Trucks, Holger; Schulz, Herbert; de Kovel, Carolien G.; Trenite, Dorothee Kasteleijn-Nolst; Sonsma, Anja C. M.; Koeleman, Bobby P.; Lindhout, Dick; Weber, Yvonne G.; Lerche, Holger; Kapser, Claudia; Schankin, Christoph J.; Kunz, Wolfram S.; Surges, Rainer; Elger, Christian E.; Gaus, Verena; Schmitz, Bettina; Helbig, Ingo; Muhle, Hiltrud; Stephani, Ulrich; Klein, Karl M.; Rosenow, Felix; Reinthaler, Eva M.; Zimprich, Fritz; Feucht, Martha; Moller, Rikke S.; Hjalgrim, Helle; De Jonghe, Peter; Suls, Arvid; Nuernberg, Peter; Sander, Thomas; EPICURE Consortium] EPICURE Consortium, Utrecht, Netherlands.
[de Kovel, Carolien G.; Sonsma, Anja C. M.; Koeleman, Bobby P.; Lindhout, Dick] Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands.
[Lindhout, Dick] SEIN Epilepsy Inst Netherlands, Hoofddorp, Netherlands.
[Weber, Yvonne G.; Lerche, Holger] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurol & Epileptol, Tubingen, Germany.
[Kapser, Claudia; Schankin, Christoph J.] Univ Munich Hosp Grosshadern, Dept Neurol, Munich, Germany.
[Kunz, Wolfram S.; Surges, Rainer; Elger, Christian E.] Univ Clin Bonn, Dept Epileptol, Bonn, Germany.
[Gaus, Verena; Schmitz, Bettina] Charite, Campus Virchow Clin, Dept Neurol, D-13353 Berlin, Germany.
[Schmitz, Bettina] Vivantes Humboldt Klinikum, Dept Neurol, Berlin, Germany.
[Helbig, Ingo; Muhle, Hiltrud; Stephani, Ulrich] Univ Med Ctr Schleswig Holstein, Dept Neuropediat, Kiel, Germany.
[Klein, Karl M.; Rosenow, Felix] Univ Marburg, Dept Neurol, Epilepsy Ctr Hessen, Marburg, Germany.
[Klein, Karl M.; Rosenow, Felix] Goethe Univ Frankfurt, Dept Neurol, Epilepsy Ctr Frankfurt Rhein Main, D-60054 Frankfurt, Germany.
[Reinthaler, Eva M.; Zimprich, Fritz] Med Univ Vienna, Dept Neurol, Vienna, Austria.
[Feucht, Martha] Med Univ Vienna, Dept Pediat & Neonatol, Vienna, Austria.
[Moller, Rikke S.; Hjalgrim, Helle] Danish Epilepsy Ctr, Dept Neurol, Dianalund, Denmark.
[Moller, Rikke S.; Hjalgrim, Helle] Univ Southern Denmark, Inst Reg Hlth Serv, Odense, Denmark.
[De Jonghe, Peter; Suls, Arvid] Univ Antwerp VIB, Dept Mol Genet, Neurogenet Grp, B-2610 Antwerp, Belgium.
[De Jonghe, Peter; Suls, Arvid] Univ Antwerp, Inst Born Bunge, Neurogenet Lab, B-2020 Antwerp, Belgium.
[Lieb, Wolfgang] Univ Kiel, Inst Epidemiol, Kiel, Germany.
[Lieb, Wolfgang] Univ Kiel, Biobank Popgen, Kiel, Germany.
[Franke, Andre] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.
[Strauch, Konstantin; Gieger, Christian] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.
[Strauch, Konstantin] Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany.
[Strauch, Konstantin] Univ Munich, Chair Genet Epidemiol, Munich, Germany.
[Gieger, Christian] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.
[Gieger, Christian] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.
[Schurmann, Claudia] Ernst Moritz Arndt Univ Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.
[Schminke, Ulf] Ernst Moritz Arndt Univ Greifswald, Univ Med Greifswald, Dept Neurol, Greifswald, Germany.
[Nuernberg, Peter] Univ Cologne, CMMC, D-50931 Cologne, Germany.
RP Lal, D (reprint author), Univ Cologne, CCG, D-50931 Cologne, Germany.
EM sandert@uni-koeln.de
FU European Community [LSHM-CT-2006-037315, 602531]; German Research
Foundation (DFG) within the EUROCORES Programme EuroEPINOMICS
[Le1030/11-1, NU50/8-1, SA434/5-1, SA434/4-2]; German Federal Ministry
of Education and Research, National Genome Research Network [NGFNplus:
EMINet] [01GS08120, 01GS08123]; Netherlands National Epilepsy Fund
[04-08]; Netherlands Organization for Scientific Research [917.66.315];
Fund for Scientific Research Flanders (FWO); PopGen biobank; German
Federal Ministry of Education and Research [01EY1103]; Helmholtz Zentrum
Munchen - German Research Center for Environmental Health - German
Federal Ministry of Education and Research; State of Bavaria; Munich
Center of Health Sciences (MC Health) as part of LMUinnovativ; Federal
Ministry of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0701,
03ZIK012]; Ministry of Cultural Affairs; Social Ministry of the Federal
State of Mecklenburg-West Pomerania; Siemens Healthcare, Erlangen,
Germany; Federal State of Mecklenburg-West Pomerania
FX This work was supported by grants from the European Community [FP6
Integrated Project EPICURE, grant LSHM-CT-2006-037315 to BPK, HL, and
TS; and FP7 Project DESIRE, grant 602531 to TS], the German Research
Foundation (DFG) within the EUROCORES Programme EuroEPINOMICS [grants
Le1030/11-1 to HL, NU50/8-1 to PN, SA434/5-1 & SA434/4-2 to TS], the
German Federal Ministry of Education and Research, National Genome
Research Network [NGFNplus: EMINet, grants 01GS08120 to TS, and
01GS08123 to HL], The Netherlands National Epilepsy Fund [grant 04-08 to
BPK], The Netherlands Organization for Scientific Research [grant
917.66.315 to BPK and CGdK], the Fund for Scientific Research Flanders
(FWO) [grant to PDJ], and the PopGen biobank [grant to AF]. AS is a
postdoctoral fellow of the Fund for Scientific Research Flanders (FWO).
The PopGen project received infrastructure support through the German
Research Foundation excellence cluster "Inflammation at Interfaces"
(EXC306/2). The PopGen 2.0 network is supported by a grant from the
German Federal Ministry of Education and Research (01EY1103). The KORA
research platform (KORA, Cooperative Research in the Region of Augsburg)
was initiated and financed by the Helmholtz Zentrum Munchen - German
Research Center for Environmental Health, which is funded by the German
Federal Ministry of Education and Research and by the State of Bavaria;
this research was supported within the Munich Center of Health Sciences
(MC Health) as part of LMUinnovativ. The Study of Health in Pomerania
(SHIP) is part of the Community Medicine Research Net of the University
of Greifswald, Germany, which is funded by the Federal Ministry of
Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0701),
the Ministry of Cultural Affairs, and the Social Ministry of the Federal
State of Mecklenburg-West Pomerania. Genome-wide data have been
supported by the Federal Ministry of Education and Research (grant no.
03ZIK012) and a joint grant from Siemens Healthcare, Erlangen, Germany,
and the Federal State of Mecklenburg-West Pomerania. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
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NR 114
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7390
EI 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD MAY
PY 2015
VL 11
IS 5
AR e1005226
DI 10.1371/journal.pgen.1005226
PG 21
WC Genetics & Heredity
SC Genetics & Heredity
GA CJ2HQ
UT WOS:000355305200039
PM 25950944
ER
PT J
AU Van Damme, T
Sabbe, B
van West, D
Simons, J
AF Van Damme, Tine
Sabbe, Bernard
van West, Dirk
Simons, Johan
TI Motor abilities of adolescents with a disruptive behavior disorder: The
role of comorbidity with ADHD
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Motor abilities; Disruptive behavior disorder; ADHD; Adolescent;
Bruininks-Oseretsky test of motor proficiency
ID DEVELOPMENTAL COORDINATION DISORDER; DEFICIT-HYPERACTIVITY DISORDER;
OPPOSITIONAL DEFIANT DISORDER; AUTISM SPECTRUM DISORDER; 6-YEAR-OLD
CHILDREN; GENDER-DIFFERENCES; PHYSICAL-FITNESS; ATTENTION; PERFORMANCE;
AGE
AB The aim of this study was to explore the incidence, type and severity of motor impairment in male adolescents with a disruptive behavior disorder (DBD) and evaluate the role of comorbid ADHD. The Bruininks-Oseretsky test of motor proficiency, Second Edition was administered to examine a detailed motor profile and to compare the motor abilities of individuals with DBD (n = 99) to those of controls (n = 87). Additional subgroup analyses were conducted within the clinical population and encompassed (1) analyzing differences in motor profiles between individuals diagnosed with oppositional defiant disorder (ODD) or conduct disorder (CD) and (2) comparing the motor profiles of individuals with or without comorbid ADHD. The results indicated that individuals with a DBD showed a mixed motor impairment profile. Even after controlling for IQ, the DBD group obtained significantly lower scores in comparison to controls. The ODD and CD subgroups showed a similar motor profile. Presence of comorbid ADHD did not produce major differences in the motor profile. As approximately 79% of the adolescents with a DBD suffered from motor impairment, motor ability needs to be adequately addressed in research as well as in clinical practice. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Van Damme, Tine; Sabbe, Bernard; van West, Dirk] Univ Antwerp, Collaborat Antwerp Psychiat Res Inst, Fac Med & Hlth Sci, B-2610 Antwerp, Belgium.
[Van Damme, Tine; van West, Dirk] ZNA, Univ Ctr Child & Adolescent Psychiat Antwerp, B-2020 Antwerp, Belgium.
[van West, Dirk] Vrije Univ Brussel, Dept Clin & Lifespan Psychol, Fac Psychol, B-1050 Brussels, Belgium.
[Simons, Johan] Katholieke Univ Leuven, Dept Rehabil Sci, Fac Kinesiol & Rehabil Sci, B-3001 Heverlee, Belgium.
RP Van Damme, T (reprint author), Collaborat Antwerp Psychiat Res Inst, Univ Pl 1, B-2610 Antwerp, Belgium.
EM Tine.Vandamme@zna.be; Bernard.Sabbe@uantwerpen.be; Dirk.vanwest@zna.be;
Johan.Simons@faber.kuleuven.be
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NR 48
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY
PY 2015
VL 40
BP 1
EP 10
DI 10.1016/j.ridd.2015.01.004
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI6XD
UT WOS:000354906600001
PM 25697736
ER
PT J
AU Smith, KA
Shepley, SB
Alexander, JL
Ayres, KM
AF Smith, Katie A.
Shepley, Sally B.
Alexander, Jennifer L.
Ayres, Kevin M.
TI The independent use of self-instructions for the acquisition of
untrained multi-step tasks for individuals with an intellectual
disability: A review of the literature
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Review
DE Intellectual disability; Self-instruction; Self-prompting;
Student-directed; Self-directed
ID PERSONAL DIGITAL ASSISTANT; SEVERELY HANDICAPPED ADOLESCENTS; AUTISM
SPECTRUM DISORDERS; DAILY LIVING SKILLS; PICTURE PROMPTS; YOUNG-ADULTS;
DEVELOPMENTAL-DISABILITIES; VOCATIONAL TASKS; COOKING SKILLS; STUDENTS
AB Systematic instruction on multi-step tasks (e.g., cooking, vocational skills, personal hygiene) is common for individuals with an intellectual disability. Unfortunately, when individuals with disabilities turn 22-years-old, they no longer receive services in the public school system in most states and systematic instruction often ends (Bouck, 2012). Rather than focusing instructional time on teacher-delivered training on the acquisition of specific multi-step tasks, teaching individuals with disabilities a pivotal skill, such as using self-instructional strategies, may be a more meaningful use of time. By learning self-instruction strategies that focus on generalization, individuals with disabilities can continue acquiring novel multi-step tasks in post-secondary settings and remediate skills that are lost over time. This review synthesizes the past 30 years of research related to generalized self-instruction to learn multi-step tasks, provides information about the types of self-instructional materials used, the ways in which participants received training to use them, and concludes with implications for practitioners and recommendations for future research. Published by Elsevier Ltd.
C1 [Smith, Katie A.; Shepley, Sally B.; Alexander, Jennifer L.; Ayres, Kevin M.] Univ Georgia, Athens, GA 30602 USA.
[Shepley, Sally B.] UGA, Coll Educ, Athens, GA 30602 USA.
RP Shepley, SB (reprint author), UGA, Coll Educ, 518 Aderhold Hall, Athens, GA 30602 USA.
EM sallybshepley@gmail.com
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NR 35
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY
PY 2015
VL 40
BP 19
EP 30
DI 10.1016/j.ridd.2015.01.010
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI6XD
UT WOS:000354906600003
ER
PT J
AU Davidson, C
O'Hare, A
Mactaggart, F
Green, J
Young, D
Gillberg, C
Minnis, H
AF Davidson, Claire
O'Hare, Anne
Mactaggart, Fiona
Green, Jonathan
Young, David
Gillberg, Christopher
Minnis, Helen
TI Social relationship difficulties in autism and reactive attachment
disorder: Improving diagnostic validity through structured assessment
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE Reactive attachment disorder; Autism spectrum disorder; Indiscriminate
friendliness; Social relationships; Differential diagnosis; Observation
ID SPECTRUM DISORDERS; CHILDREN; PREVALENCE; BEHAVIORS; ASSOCIATION;
POPULATION; ADOPTEES; DEFICITS; ALCOHOL
AB Background: Autism Spectrum Disorder (ASD) versus Reactive Attachment Disorder (RAD) is a common diagnostic challenge for clinicians due to overlapping difficulties with social relationships. RAD is associated with neglect or maltreatment whereas ASD is not: accurate differential diagnosis is therefore critical. Very little research has investigated the relationship between the two, and it is unknown if standardised measures are able to discriminate between ASD and RAD. The current study aimed to address these issues.
Methods: Fifty eight children with ASD, and no history of maltreatment, were group matched on age with 67 children with RAD. Group profiles on multi-informant measures of RAD were investigated and group differences explored. Discriminant function analysis determined assessment features that best discriminated between the two groups.
Results: Although, according to parent report, children with ASD presented with significantly fewer indiscriminate friendliness behaviours compared to the RAD group (p < 0.001), 36 children with ASD appeared to meet core RAD criteria. However, structured observation clearly demonstrated that features were indicative of ASD and not RAD for all but 1 of these 36 children.
Conclusions: Children with RAD and children with ASD may demonstrate similar social relationship difficulties but there appears to be a difference in the social quality of the interactions between the groups. In most cases it was possible to differentiate between children with ASD and children with RAD via structured observation. Nevertheless, for a small proportion of children with ASD, particularly those whose difficulties may be more subtle, our current standardised measures, including structured observation, may not be effective in differentiating RAD from ASD. (C) 2015 Published by Elsevier Ltd.
C1 [Davidson, Claire; Gillberg, Christopher; Minnis, Helen] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland.
[O'Hare, Anne] Univ Edinburgh, Dept Child Life & Hlth, Edinburgh, Midlothian, Scotland.
[Mactaggart, Fiona] North Edinburgh Team, Child & Adolescent Mental Hlth Serv, Edinburgh Connect & North Edinburgh Team, Edinburgh, Midlothian, Scotland.
[Green, Jonathan] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England.
[Young, David] Univ Strathclyde, Dept Math & Stat, Glasgow, Lanark, Scotland.
[Gillberg, Christopher] Univ Gothenburg, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
RP Davidson, C (reprint author), Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland.
EM claire.davidson@glasgow.ac.uk; aohare@ed.ac.uk;
Fiona.Mactaggart@nhslothian.scot.nhs.uk;
Jonathan.Green@manchester.co.uk; David.Young@strath.ac.uk;
christopher.gillberg@gnc.gu.se
FU Chief Scientist Office (Scotland) [CZH/4/651]; Sick Kids Friends
Foundation
FX We are grateful to all participating families, and to the following
people who helped with rating of research instruments: Ashley Cameron,
Manju Haridas, Franciske Evans, Helen Dawson, Saman Khan, Shubha Hegde,
Sadia Mohammad, Laxmi Kathuria and Christine Clark. We are also grateful
to Susan Davidson and Irene O'Neill for administrative support, to the
Edinburgh RHSC Clinical Research Facility for use of their facilities
and to the funders: the Chief Scientist Office (Scotland CZH/4/651) and
the Sick Kids Friends Foundation.
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NR 47
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY
PY 2015
VL 40
BP 63
EP 72
DI 10.1016/j.ridd.2015.01.007
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI6XD
UT WOS:000354906600007
PM 25754456
ER
PT J
AU Limoges, E
Bolduc, C
Berthiaume, C
Mottron, L
Godbout, R
AF Limoges, Elyse
Bolduc, Christianne
Berthiaume, Claude
Mottron, Laurent
Godbout, Roger
TI Relationship between poor sleep and daytime cognitive performance in
young adults with autism (vol 34, pg 1322, 2013)
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Correction
C1 [Limoges, Elyse; Bolduc, Christianne; Berthiaume, Claude; Godbout, Roger] Hop Riviere des Prairies, Sleep Lab & Clin, Montreal, PQ H1E 1A4, Canada.
[Limoges, Elyse; Bolduc, Christianne; Mottron, Laurent; Godbout, Roger] Hop Riviere des Prairies, Ctr Rech Fernand Seguin, Montreal, PQ H1E 1A4, Canada.
[Mottron, Laurent] Hop Riviere des Prairies, Autism Clin, Montreal, PQ H1E 1A4, Canada.
[Mottron, Laurent; Godbout, Roger] Univ Montreal, Dept Psychiat, Downtown Branch, Montreal, PQ H1E 1A4, Canada.
RP Godbout, R (reprint author), Hop Riviere des Prairies, Sleep Lab & Clin, 7070 Perras Blvd, Montreal, PQ H1E 1A4, Canada.
EM roger.godbout@umontreal.ca
CR Limoges E, 2013, RES DEV DISABIL, V34, P1322, DOI 10.1016/j.ridd.2013.01.013
NR 1
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD MAY
PY 2015
VL 40
BP 73
EP 73
DI 10.1016/j.ridd.2015.03.001
PG 1
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI6XD
UT WOS:000354906600008
ER
PT J
AU Overgaauw, S
van Duijvenvoorde, ACK
Moor, BG
Crone, EA
AF Overgaauw, Sandy
van Duijvenvoorde, Anna C. K.
Moor, Bregtje Gunther
Crone, Eveline A.
TI A longitudinal analysis of neural regions involved in reading the mind
in the eyes
SO SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
LA English
DT Article
DE social brain; longitudinal design; mentalizing; adolescence; development
ID TEST-RETEST RELIABILITY; INFERIOR FRONTAL GYRUS; ASPERGER-SYNDROME;
EARLY ADULTHOOD; ADOLESCENCE; AUTISM; BRAIN; FMRI; METAANALYSIS;
CHILDHOOD
AB The ability to perceive social intentions from people's eyes is present from an early age, yet little is known about whether this skill is fully developed in childhood or that subtle changes may still occur across adolescence. This fMRI study investigated the ability to read mental states by using an adapted version of the Reading the Mind in the Eyes task within adolescents (aged 12-19 years) over a 2-year test-retest interval. This longitudinal setup provides the opportunity to study both stability over time as well as age-related changes. The behavioral results showed that participants who performed well in the mental state condition at the first measurement also performed well at the second measurement. fMRI results revealed positive test-retest correlations of neural activity in the right superior temporal sulcus and right inferior frontal gyrus for the contrast mental state > control, suggesting stability within individuals over time. Besides stability of activation, dorsal medial prefrontal cortex showed a dip in mid-adolescence for the mental state > control condition and right inferior frontal gyrus decreased linearly with age for the mental state > control condition. These findings underline changes in the slope of the developmental pattern depending on age, even in the existence of relatively stable activation in the social brain network.
C1 [Overgaauw, Sandy; van Duijvenvoorde, Anna C. K.; Moor, Bregtje Gunther; Crone, Eveline A.] Leiden Univ, Dept Dev Psychol, NL-2333 AK Leiden, Netherlands.
[Overgaauw, Sandy; van Duijvenvoorde, Anna C. K.; Crone, Eveline A.] Leiden Inst Brain & Cognit, Leiden, Netherlands.
RP Overgaauw, S (reprint author), Leiden Univ, Inst Psychol, Wassenaarseweg 52, NL-2333 AK Leiden, Netherlands.
EM s.overgaauw.2@fsw.leidenuniv.nl
FU European Research Council [ERC-2010-StG-263234]
FX We would like to acknowledge the Autism Research Centre for the use of
the 'Reading the Mind in the Eyes task'. We are grateful to Wouter van
der Horst and Marthe de Jong for assistance in recruiting participants
and for assistance in scanning. Eveline A. Crone was supported by a
starting grant of the European Research Council (ERC-2010-StG-263234).
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Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd
NR 37
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1749-5016
EI 1749-5024
J9 SOC COGN AFFECT NEUR
JI Soc. Cogn. Affect. Neurosci.
PD MAY
PY 2015
VL 10
IS 5
BP 619
EP 627
DI 10.1093/scan/nsu095
PG 9
WC Neurosciences; Psychology; Psychology, Experimental
SC Neurosciences & Neurology; Psychology
GA CJ1ZM
UT WOS:000355283700001
PM 25062837
ER
PT J
AU Franklin, C
Gattas, M
Dossetor, D
Lennox, N
AF Franklin, C.
Gattas, M.
Dossetor, D.
Lennox, N.
TI AUTISM SPECTRUM DISORDER: ESSENTIALS FOR PSYCHIATRISTS
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Franklin, C.; Lennox, N.] Univ Queensland, MRI UQ, Queensland Ctr Intellectual & Dev Disabil, Brisbane, Qld, Australia.
[Gattas, M.] Wesley Med Ctr, Brisbane Genet, Brisbane, Qld, Australia.
[Gattas, M.] Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Brisbane, Qld, Australia.
[Dossetor, D.] Sydney Childrens Hosp Network, Sydney, NSW, Australia.
[Dossetor, D.] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.
NR 0
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAY
PY 2015
VL 49
SU 1
BP 15
EP 15
PG 1
WC Psychiatry
SC Psychiatry
GA CI0OU
UT WOS:000354437500034
ER
PT J
AU Gattas, M
AF Gattas, M.
TI GENETICS AND AUTISM SPECTRUM DISODER
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Gattas, M.] Wesley Med Ctr, Brisbane Genet, Brisbane, Qld, Australia.
[Gattas, M.] Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Brisbane, Qld, Australia.
NR 0
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAY
PY 2015
VL 49
SU 1
BP 15
EP 16
PG 2
WC Psychiatry
SC Psychiatry
GA CI0OU
UT WOS:000354437500035
ER
PT J
AU Lennox, N
AF Lennox, N.
TI PHYSICAL HEALTH IN AUTISM: COMMON CONDITIONS AND THEIR MANAGEMENT
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Lennox, N.] Univ Queensland, Queensland Ctr Intellectual & Dev Disabil, Brisbane, Qld, Australia.
NR 0
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAY
PY 2015
VL 49
SU 1
BP 16
EP 16
PG 1
WC Psychiatry
SC Psychiatry
GA CI0OU
UT WOS:000354437500037
ER
PT J
AU Franklin, C
AF Franklin, C.
TI MENTAL HEALTH IN ADULTS WITH AUTISM SPECTRUM DISORDER
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Franklin, C.] Univ Queensland, Queensland Ctr Intellectual & Dev Disabil, Brisbane, Qld, Australia.
NR 0
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAY
PY 2015
VL 49
SU 1
BP 17
EP 17
PG 1
WC Psychiatry
SC Psychiatry
GA CI0OU
UT WOS:000354437500038
ER
PT J
AU Bird, P
AF Bird, P.
TI AUTISM SPECTRUM DISORDERS - NEW TREATMENTS
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Bird, P.] Gosforth Clin, Maroochydore, Australia.
NR 0
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAY
PY 2015
VL 49
SU 1
BP 38
EP 38
PG 1
WC Psychiatry
SC Psychiatry
GA CI0OU
UT WOS:000354437500095
ER
PT J
AU Jayawardena, V
Kisely, S
Perera, H
AF Jayawardena, V.
Kisely, S.
Perera, H.
TI CAREGIVER BURDEN AND DEPRESSION AMONG CAREGIVERS OF AUTISM PRESENTING TO
A SPECIALIST CHILD MENTAL HEALTH SERVICE IN SRI LANKA
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Jayawardena, V.] West Moreton Hosp & Hlth Serv, Ipswich, Qld, Australia.
[Kisely, S.] Univ Queensland, Herston, Qld, Australia.
[Perera, H.] Univ Colombo, Dept Psychol Med, Colombo, Sri Lanka.
NR 0
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAY
PY 2015
VL 49
SU 1
BP 68
EP 68
PG 1
WC Psychiatry
SC Psychiatry
GA CI0OU
UT WOS:000354437500174
ER
PT J
AU Kondapalli, LA
Barnhart, KB
AF Kondapalli, L. A.
Barnhart, K. B.
TI Prospective Cohort Study of Autism, Neurodevelopment, and Behavior in
Young Children Conceived by Assisted Reproductive Technology (ART):
Cause for Concern or Reassurance?
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Kondapalli, L. A.] Colorado Ctr Reprod Med, Lone Tree, CO USA.
[Kondapalli, L. A.; Barnhart, K. B.] Univ Penn, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2015
VL 103
IS 5
MA S12
BP 357
EP 357
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA CI4SD
UT WOS:000354742400016
ER
PT J
AU Boukhris, T
Muanda-Tsobo, F
Berard, A
AF Boukhris, T.
Muanda-Tsobo, F.
Berard, A.
TI Antidepressant, Especially SSRI Use, during Pregnancy and the Risk of
Autism Spectrum Disorder: A Meta-Analysis
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Boukhris, T.; Muanda-Tsobo, F.; Berard, A.] Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada.
[Berard, A.] CHU St Justine, Res Ctr, Montreal, PQ, Canada.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2015
VL 103
IS 5
MA P19
BP 411
EP 411
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA CI4SD
UT WOS:000354742400119
ER
PT J
AU Colvert, E
Tick, B
McEwen, F
Stewart, C
Curran, SR
Woodhouse, E
Gillan, N
Hallett, V
Lietz, S
Garnett, T
Ronald, A
Plomin, R
Rijsdijk, F
Happe, F
Bolton, P
AF Colvert, Emma
Tick, Beata
McEwen, Fiona
Stewart, Catherine
Curran, Sarah R.
Woodhouse, Emma
Gillan, Nicola
Hallett, Victoria
Lietz, Stephanie
Garnett, Tracy
Ronald, Angelica
Plomin, Robert
Rijsdijk, Fruehling
Happe, Francesca
Bolton, Patrick
TI Heritability of Autism Spectrum Disorder in a UK Population-Based Twin
Sample
SO JAMA PSYCHIATRY
LA English
DT Article
ID GENERAL-POPULATION; GENETIC INFLUENCES; BROADER PHENOTYPE; TRAITS;
CHILDHOOD; PAIRS; SCHIZOPHRENIA; INHERITANCE; ENVIRONMENT; PREVALENCE
AB IMPORTANCE Most evidence to date highlights the importance of genetic influences on the liability to autism and related traits. However, most of these findings are derived from clinically ascertained samples, possibly missing individuals with subtler manifestations, and obtained estimates may not be representative of the population.
OBJECTIVES To establish the relative contributions of genetic and environmental factors in liability to autism spectrum disorder (ASD) and a broader autism phenotype in a large population-based twin sample and to ascertain the genetic/environmental relationship between dimensional trait measures and categorical diagnostic constructs of ASD.
DESIGN, SETTING, AND PARTICIPANTS We used data from the population-based cohort Twins Early Development Study, which included all twin pairs born in England and wales from January 1, 1994, through December 31, 1996. We performed joint continuous-ordinal liability threshold model fitting using the full information maximum likelihood method to estimate genetic and environmental parameters of covariance. Twin pairs underwent the following assessments: the Childhood Autism Spectrum Test (CAST) (6423 pairs; mean age, 7.9 years), the Development and Well-being Assessment (DAWBA) (359 pairs; mean age, 10.3 years), the Autism Diagnostic Observation Schedule (ADOS) (203 pairs; mean age, 13.2 years), the Autism Diagnostic Interview-Revised (ADI-R) (205 pairs; mean age, 13.2 years), and a best-estimate diagnosis (207 pairs).
MAIN OUTCOMES AND MEASURES Participants underwent screening using a population-based measure of autistic traits (CAST assessment), structured diagnostic assessments (DAWBA, ADI-R, and ADOS), and a best-estimate diagnosis.
RESULTS On all ASD measures, correlations among monozygotic twins (range, 0.77-0.99) were significantly higher than those for dizygotic twins (range, 0.22-0.65), giving heritability estimates of 56% to 95%. The covariance of CAST and ASD diagnostic status (DAWBA, ADOS and best-estimate diagnosis) was largely explained by additive genetic factors (76%-95%). For the ADI-R only, shared environmental influences were significant (30% [95% CI, 8%-47%]) but smaller than genetic influences (56% [95% CI, 37%-82%]).
CONCLUSIONS AND RELEVANCE The liability to ASD and a more broadly defined high-level autism trait phenotype in this large population-based twin sample derives primarily from additive genetic and, to a lesser extent, nonshared environmental effects. The largely consistent results across different diagnostic tools suggest that the results are generalizable across multiple measures and assessment methods. Genetic factors underpinning individual differences in autismlike traits show considerable overlap with genetic influences on diagnosed ASD.
C1 [Colvert, Emma; Tick, Beata; McEwen, Fiona; Ronald, Angelica; Plomin, Robert; Rijsdijk, Fruehling; Happe, Francesca; Bolton, Patrick] Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC Social Genet & Dev Psychiat Ctr, London SE5 8AF, England.
[McEwen, Fiona; Bolton, Patrick] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Child & Adolescent Psychiat, London SE5 8AF, England.
[Stewart, Catherine; Gillan, Nicola; Garnett, Tracy; Bolton, Patrick] Maudsley Hosp & Inst Psychiat, South London & Maudsley NHS Fdn Trust, London SE5 8AZ, England.
[Stewart, Catherine; Curran, Sarah R.; Hallett, Victoria] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London SE5 8AF, England.
[Curran, Sarah R.] Univ Sussex, Brighton & Sussex Med Sch, Brighton BN1 9RH, E Sussex, England.
[Curran, Sarah R.] Sussex Partnership NHS Fdn Trust, Worthing, W Sussex, England.
[Woodhouse, Emma] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Forens & Neurodev Sci, London SE5 8AF, England.
[Lietz, Stephanie] UCL, Res Dept Clin Educ & Hlth Psychol, London, England.
[Ronald, Angelica] Univ London, Dept Psychol Sci, London, England.
RP Tick, B (reprint author), Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC Social Genet & Dev Psychiat Ctr, Crespigny Pk, London SE5 8AF, England.
EM beata.b.tick@kcl.ac.uk
FU UK Medical Research Council (MRC) [G0901245, G0500079]; MRC [G0500870,
MR/J500380/1]; National Institute for Health Research; Biomedical
Research Centre in Mental Health at South London and Maudsley NHS Trust;
Autism Speaks grant
FX The Twins Early Development Study (TEDS) is supported by program grant
G0901245 (previously G0500079) from the UK Medical Research Council
(MRC). The Social Relationship Study was supported by grant G0500870
from the MRC. This study is also supported by 1+3 PhD studentship
MR/J500380/1 from the MRC (Ms Tick), by a senior investigator award from
the National Institute for Health Research (Dr Bolton), by the
Biomedical Research Centre in Mental Health at the South London and
Maudsley NHS Trust (Dr Bolton), and by an Autism Speaks grant (Dr
Bolton).
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NR 55
TC 0
Z9 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD MAY
PY 2015
VL 72
IS 5
BP 415
EP 423
DI 10.1001/jamapsychiatry.2014.3028
PG 9
WC Psychiatry
SC Psychiatry
GA CH6YC
UT WOS:000354181400003
PM 25738232
ER
PT J
AU Bresnahan, M
Hornig, M
Schultz, AF
Gunnes, N
Hirtz, D
Lie, KK
Magnus, P
Reichborn-Kjennerud, T
Roth, C
Schjolberg, S
Stoltenberg, C
Suren, P
Susser, E
Lipkin, WI
AF Bresnahan, Michaeline
Hornig, Mady
Schultz, Andrew F.
Gunnes, Nina
Hirtz, Deborah
Lie, Kari Kveim
Magnus, Per
Reichborn-Kjennerud, Ted
Roth, Christine
Schjolberg, Synnve
Stoltenberg, Camilla
Suren, Pal
Susser, Ezra
Lipkin, W. Ian
TI Association of Maternal Report of Infant and Toddler Gastrointestinal
Symptoms With Autism Evidence From a Prospective Birth Cohort
SO JAMA PSYCHIATRY
LA English
DT Article
ID SPECTRUM DISORDERS; YOUNG-CHILDREN; LANGUAGE DELAY; SEROTONIN;
INDIVIDUALS; DYSFUNCTION; MET; DIAGNOSIS; PATTERNS; SYSTEM
AB IMPORTANCE Gastrointestinal (GI) comorbidities are frequently described in association with autism spectrum disorder (ASD). However, the prevalence of GI disturbances and the age at which such problems first appear are unclear, and their specificity for ASD compared with other neurodevelopmental disorders is uncertain.
OBJECTIVE To compare maternal report of GI symptoms during the first 3 years of life in children with ASD, developmental delay (DD), and typical development (TD).
DESIGN, SETTING, AND PARTICIPANTS This large prospective cohort study consists of participants in the Norwegian Mother and Child Cohort Study. During a 10-year period (January 1, 1999, through December 31, 2008), women throughout Norway were recruited at the first prenatal ultrasonographic visit (approximately 18 weeks' gestation). The study enrolled 95 278 mothers, 75 248 fathers, and 114 516 children. Our analyses are based on MoBa data released through October 1, 2013, and NPR diagnoses registered through December 31, 2012, and include children born from January 1, 2002, through December 31, 2008, with completed age 18- and 36-month questionnaires.
EXPOSURES We defined 3 groups of children: children with ASD (n = 195), children with DD and delayed language and/or motor development (n = 4636), and children with TD (n = 40 295).
MAIN OUTCOMES AND MEASURES The GI symptoms were based on maternal report of constipation, diarrhea, and food allergy/intolerance.
RESULTS Children with ASD were at significantly increased odds of maternally reported constipation (adjusted odds ratio [aOR], 2.7; 95% CI, 1.9-3.8; P < .001) and food allergy/intolerance (aOR, 1.7; 95% CI, 1.1-2.6; P = .01) in the 6- to 18-month-old age period and diarrhea (aOR, 2.3; 95% CI, 1.5-3.6; P < .001), constipation (aOR, 1.6; 95% CI, 1.2-2.3; P < .01), and food allergy/intolerance (aOR, 2.0; 95% CI, 1.3-3.1; P < .01) in the 18- to 36-month-old age period compared with children with TD. Similar results for these symptom categories were observed in comparisons with children with DD, but ORs were slightly lower. Mothers of children with ASD were significantly more likely to report 1 or more GI symptom in either the 6- to 18-month or the 18-to 36-month-old age period and more than twice as likely to report at least 1 GI symptom in both age periods compared with mothers of children with TD or DD.
CONCLUSIONS AND RELEVANCE In this large prospective cohort, maternally reported GI symptoms are more common and more often persistent during the first 3 years of life in children with ASD than in children with TD or DD.
C1 [Bresnahan, Michaeline; Hornig, Mady; Roth, Christine; Susser, Ezra; Lipkin, W. Ian] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.
[Bresnahan, Michaeline; Susser, Ezra] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
[Hornig, Mady; Schultz, Andrew F.; Lipkin, W. Ian] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY 10032 USA.
[Gunnes, Nina; Lie, Kari Kveim; Magnus, Per; Reichborn-Kjennerud, Ted; Roth, Christine; Schjolberg, Synnve; Stoltenberg, Camilla; Suren, Pal] Norwegian Inst Publ Hlth, Oslo, Norway.
[Hirtz, Deborah] Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA.
[Reichborn-Kjennerud, Ted] Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.
RP Bresnahan, M (reprint author), Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, 622W168th St,Room 809, New York, NY 10032 USA.
EM mab29@columbia.edu
FU Norwegian Ministry of Health and Care Services; Norwegian Ministry of
Education and Research; National Institutes of Health/National Institute
of Neurological Disorders and Stroke [NS47537]; Research Council of
Norway [189457, 190694, 196452]
FX This research was supported by the Norwegian Ministry of Health and Care
Services, the Norwegian Ministry of Education and Research, and grant
NS47537 from the National Institutes of Health/National Institute of
Neurological Disorders and Stroke (Dr Lipkin). The following grants from
the Research Council of Norway have provided support to the ABC in
general: 189457, 190694, and 196452.
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NR 42
TC 0
Z9 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD MAY
PY 2015
VL 72
IS 5
BP 466
EP 474
DI 10.1001/jamapsychiatry.2014.3034
PG 9
WC Psychiatry
SC Psychiatry
GA CH6YC
UT WOS:000354181400009
PM 25806498
ER
PT J
AU Selten, JP
Lundberg, M
Rai, D
Magnusson, C
AF Selten, Jean-Paul
Lundberg, Michael
Rai, Dheeraj
Magnusson, Cecilia
TI Risks for Nonaffective Psychotic Disorder and Bipolar Disorder in Young
People With Autism Spectrum Disorder A Population-Based Study
SO JAMA PSYCHIATRY
LA English
DT Article
ID SOCIAL DEFEAT HYPOTHESIS; PSYCHIATRIC-DISORDERS; SOCIOECONOMIC-STATUS;
SCHIZOPHRENIA; CHILDHOOD; ASSOCIATION; CHILDREN; ADULTS; INTELLIGENCE;
EXPERIENCES
AB IMPORTANCE Whether individuals with autism spectrum disorder (ASD) are at increased risk for nonaffective psychotic disorder (NAPD) or bipolar disorder (BD) is unknown.
OBJECTIVE To test whether the risks for NAPD and BD in individuals with ASD are increased and whether these risks are higher than those of their siblings not diagnosed as having ASD.
DESIGN, SETTING, AND PARTICIPANTS We performed a nested case-control study of all individuals 17 years or younger who ever resided in Stockholm County, Sweden, from January 1, 2001, through December 31, 2011 (Stockholm Youth Cohort). We included cohort members ever diagnosed as having ASD (n = 9062) and their full siblings never diagnosed as having ASD. Each case was matched with 10 control individuals of the same sex born during the same month and year. Using Swedish registers, cases, siblings, and controls were followed up until December 31, 2011. By then, the oldest individuals had reached the age of 27 years.
EXPOSURES Autism spectrum disorder, registered before age 16 or 28 years. We distinguished between ASD with and without intellectual disability (ID).
MAIN OUTCOMES AND MEASURES We calculated odds ratios (ORs) for NAPD and BD adjusted for age, sex, population density of place of birth, personal or parental history of migration, hearing impairment, parental age, parental income, parental educational level, and parental history of psychiatric disorder.
RESULTS The adjusted ORs for NAPD and BD for cases with non-ID ASD registered before age 16 years were 5.6 (95% CI, 3.3-8.5) and 5.8 (95% CI, 3.9-8.7), respectively; the adjusted ORs for cases with ID ASD were 3.5 (95% CI, 2.0-6.0) and 1.8 (95% CI, 0.8-4.1). The adjusted ORs for NAPD and BD in cases with non-ID ASD registered before age 28 years were 12.3 (95% CI, 9.5-15.9) and 8.5 (95% CI, 6.5-11.2), respectively; for cases with ID ASD, these ORs were 6.4 (95% CI, 4.2-9.8) and 2.0 (95% CI, 1.0-3.9), respectively. The ORs for NAPD and BD for the nonautistic full siblings of cases for whom ASD was registered before age 16 years, adjusted for hearing loss, were 1.8 (95% CI, 1.1-2.7) and 1.7 (95% CI, 1.1-2.6), respectively.
CONCLUSIONS AND RELEVANCE A diagnosis of ASD is associated with a substantially increased risk for NAPD and BD. This finding contributes to our understanding of these disorders and has implications for the management of ASD.
C1 [Selten, Jean-Paul] Maastricht Univ, Sch Mental Hlth & Neurosci, NL-6200 MD Maastricht, Netherlands.
[Selten, Jean-Paul] Rivierduinen Psychiat Inst, NL-2333 ZZ Leiden, Netherlands.
[Lundberg, Michael; Magnusson, Cecilia] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
[Selten, Jean-Paul; Magnusson, Cecilia] Stockholm Cty Council, Ctr Epidemiol & Community Med, Stockholm, Sweden.
[Rai, Dheeraj] Univ Bristol, Sch Social & Community Med, Ctr Acad Mental Hlth, Bristol, Avon, England.
[Rai, Dheeraj] Avon & Wiltshire Mental Hlth Partnership NHS Natl, Bristol Autism Spectrum Serv, Bristol, England.
RP Selten, JP (reprint author), Rivierduinen Psychiat Inst, Sandifortdreef 19, NL-2333 ZZ Leiden, Netherlands.
EM j.selten@ggzleiden.nl
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 47
TC 0
Z9 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD MAY
PY 2015
VL 72
IS 5
BP 483
EP 489
DI 10.1001/jamapsychiatry.2014.3059
PG 7
WC Psychiatry
SC Psychiatry
GA CH6YC
UT WOS:000354181400011
PM 25806797
ER
PT J
AU Verbitsky, M
Sanna-Cherchi, S
Fasel, DA
Levy, B
Kiryluk, K
Wuttke, M
Abraham, AG
Kaskel, F
Kottgen, A
Warady, BA
Furth, SL
Wong, CS
Gharavi, AG
AF Verbitsky, Miguel
Sanna-Cherchi, Simone
Fasel, David A.
Levy, Brynn
Kiryluk, Krzysztof
Wuttke, Matthias
Abraham, Alison G.
Kaskel, Frederick
Koettgen, Anna
Warady, Bradley A.
Furth, Susan L.
Wong, Craig S.
Gharavi, All G.
TI Genomic imbalances in pediatric patients with chronic kidney disease
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID COPY-NUMBER VARIANTS; CHROMOSOMAL MICROARRAY; DEVELOPMENTAL DELAY;
PROSPECTIVE COHORT; DISORDERS; CHILDREN; AUTISM; ASSOCIATION;
POPULATION; GENES
AB BACKGROUND. There is frequent uncertainty in the identification of specific etiologies of chronic kidney disease (CKD) in children. Recent studies indicate that chromosomal microarrays can identify rare genomic imbalances that can clarify the etiology of neurodevelopmental and cardiac disorders in children; however, the contribution of unsuspected genomic imbalance to the incidence of pediatric CKD is unknown.
METHODS. We performed chromosomal microarrays to detect genomic imbalances in children enrolled in the Chronic Kidney Disease in Children (CKiD) prospective cohort study, a longitudinal prospective multiethnic observational study of North American children with mild to moderate CKD. Patients with clinically detectable syndromic disease were excluded from evaluation. We compared 419 unrelated children enrolled in MD to multiethnic cohorts of 21,575 children and adults that had undergone microarray genotyping for studies unrelated to CKD.
RESULTS. We identified diagnostic copy number disorders in 31 children with CKD (7.4% of the cohort). We detected 10 known pathogenic genomic disorders, including the 17q12 deletion HNF1 homeobox B (HNF1B) and triple X syndromes in 19 of 419 unrelated CKiD cases as compared with 98 of 21,575 control individuals (OR 10.8, P = 6.1 x 10(-20)). In an additional 12 CKiD cases, we identified 12 likely pathogenic genomic imbalances that would be considered reportable in a clinical setting. These genomic imbalances were evenly distributed among patients diagnosed with congenital and noncongenital forms of CKD. In the vast majority of these cases, the genomic lesion was unsuspected based on the clinical assessment and either reclassified the disease or provided information that might have triggered additional clinical care, such as evaluation for metabolic or neuropsychiatric disease.
CONCLUSION. A substantial proportion of children with CKD have an unsuspected genomic imbalance, suggesting genomic disorders as a risk factor for common forms of pediatric nephropathy. Detection of pathogenic imbalances has practical implications for personalized diagnosis and health monitoring in this population.
C1 [Verbitsky, Miguel; Sanna-Cherchi, Simone; Fasel, David A.; Kiryluk, Krzysztof; Gharavi, All G.] Columbia Univ, Coll Phys & Surg, Dept Med, Div Pathol, New York, NY USA.
[Levy, Brynn] Columbia Univ, Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY USA.
[Wuttke, Matthias; Koettgen, Anna] Univ Freiburg, Med Ctr, Dept Nephrol, D-79106 Freiburg, Germany.
[Abraham, Alison G.; Koettgen, Anna] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Kaskel, Frederick] Albert Einstein Coll Med, Div Pediat Nephrol, New York, NY USA.
[Warady, Bradley A.] Childrens Mercy Hosp, Div Pediat Nephrol, Kansas City, MO 64108 USA.
[Furth, Susan L.] Univ Penn, Childrens Hosp Philadelphia, Perelmen Sch Med, Dept Pediat,Div Nephrol, Philadelphia, PA 19104 USA.
[Furth, Susan L.] Univ Penn, Childrens Hosp Philadelphia, Perelmen Sch Med, Dept Epidemiol,Div Nephrol, Philadelphia, PA 19104 USA.
[Wong, Craig S.] Univ New Mexico, Childrens Hosp, Albuquerque, NM 87131 USA.
RP Wong, CS (reprint author), Univ New Mexico, Childrens Hosp, Div Pediat Nephrol, MSC10-55901, Albuquerque, NM 87131 USA.
EM cwong@salud.unm.edu; ag2239@columbia.edu
FU NIH; National Institutes of Diabetes and Digestive and Kidney Diseases
(NIDDK); National Institute of Child Health and Human Development;
National Heart, Lung, and Blood Institute
FX This work was supported by the NIH, the National Institutes of Diabetes
and Digestive and Kidney Diseases (NIDDK), the National Institute of
Child Health and Human Development, and the National Heart, Lung, and
Blood Institute.
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NR 36
TC 1
Z9 1
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD MAY
PY 2015
VL 125
IS 5
BP 2171
EP 2178
DI 10.1172/1080877
PG 8
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CH5JK
UT WOS:000354071700036
PM 25893603
ER
PT J
AU Fukai, R
Hiraki, Y
Yofune, H
Tsurusaki, Y
Nakashima, M
Saitsu, H
Tanaka, F
Miyake, N
Matsumoto, N
AF Fukai, Ryoko
Hiraki, Yoko
Yofune, Hiroko
Tsurusaki, Yoshinori
Nakashima, Mitsuko
Saitsu, Hirotomo
Tanaka, Fumiaki
Miyake, Noriko
Matsumoto, Naomichi
TI A case of autism spectrum disorder arising from a de novo missense
mutation in POGZ
SO JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID GENETICS; GENES
AB Autism spectrum disorder (ASD) is a clinically heterogeneous psychiatric disorder with various genetic backgrounds. Here, we report a novel mutation in the pogo transposable element-derived protein with zinc finger domain gene (POGZ) identified by triobased whole exome sequencing. To date, a total of seven de novo POGZ mutations in ASD have been reported. POGZ contains a total of five functional domains, and this study reports the first de novo missense mutation in the centromere protein B-like DNA-binding domain. POGZ is highly expressed in the human fetal brain and is involved in mitosis and the regulation of neuronal proliferation. Therefore its loss-of-function or pathogenic missense mutations are likely to be causative of ASD.
C1 [Fukai, Ryoko; Tsurusaki, Yoshinori; Nakashima, Mitsuko; Saitsu, Hirotomo; Miyake, Noriko; Matsumoto, Naomichi] Yokohama City Univ, Grad Sch Med, Dept Human Genet, Yokohama, Kanagawa 2360004, Japan.
[Fukai, Ryoko; Tanaka, Fumiaki] Yokohama City Univ, Grad Sch Med, Dept Neurol & Stroke Med, Yokohama, Kanagawa 2360004, Japan.
[Hiraki, Yoko] Hiroshima Municipal Ctr Child Hlth & Dev, Hiroshima, Japan.
[Yofune, Hiroko] Hiroshima City Hokubu Ctr Childrens Treatment & G, Hiroshima, Japan.
RP Miyake, N (reprint author), Yokohama City Univ, Grad Sch Med, Dept Human Genet, Kanazawa Ku, Fukuura 3-9, Yokohama, Kanagawa 2360004, Japan.
EM nmiyake@yokohama-cu.ac.jp; naomat@yokohama-cu.ac.jp
FU Ministry of Health, Labour and Welfare of Japan; Japan Science and
Technology Agency; Strategic Research Program for Brain Sciences;
Ministry of Education, Culture, Sports, Science and Technology of Japan;
Japan Society for the Promotion of Science; Takeda Science Foundation;
Hayashi Memorial Foundation for Female Natural Scientists
FX We thank the patient's family for participating in this work. This work
was supported by research grants from the Ministry of Health, Labour and
Welfare of Japan (HS, N Matsumoto, N Miyake), the fund for Creation of
Innovation Centers for Advanced Interdisciplinary Research Areas Program
in the Project for Developing Innovation Systems from the Japan Science
and Technology Agency (N Matsumoto), the Strategic Research Program for
Brain Sciences (N Matsumoto) and a Grant-in-Aid for Scientific Research
on Innovative areas-(Transcription cycle)-from the Ministry of
Education, Culture, Sports, Science and Technology of Japan (N
Matsumoto), Grants-in-Aid for Scientific Research (A) and (B) from the
Japan Society for the Promotion of Science (HS, N Miyake, N Matsumoto),
the Takeda Science Foundation (N Matsumoto, N Miyake), the Yokohama
Foundation for Advancement of Medical Science (N Miyake) and the Hayashi
Memorial Foundation for Female Natural Scientists (N Miyake).
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NR 20
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1434-5161
EI 1435-232X
J9 J HUM GENET
JI J. Hum. Genet.
PD MAY
PY 2015
VL 60
IS 5
BP 277
EP 279
DI 10.1038/jhg.2015.13
PG 3
WC Genetics & Heredity
SC Genetics & Heredity
GA CI8IO
UT WOS:000355016200008
PM 25694107
ER
PT J
AU Duerden, EG
Taylor, MJ
Lee, M
McGrath, PA
Davis, KD
Roberts, SW
AF Duerden, Emma G.
Taylor, Margot J.
Lee, Minha
McGrath, Patricia A.
Davis, Karen D.
Roberts, S. Wendy
TI Decreased Sensitivity to Thermal Stimuli in Adolescents With Autism
Spectrum Disorder: Relation to Symptomatology and Cognitive Ability
SO JOURNAL OF PAIN
LA English
DT Article
DE Cognition; pain; perception; autism; human
ID WARM FIBERS; COMMUNICATION DISORDERS; DIAGNOSTIC INTERVIEW; INCREMENTAL
CHANGES; BRAIN POTENTIALS; SKIN TEMPERATURE; PAIN THRESHOLDS;
BETA-ENDORPHIN; REACTION-TIMES; NERVE BLOCK
AB Social communication deficits and repetitive behaviors are established characteristics of autism spectrum disorder (ASD) and the focus of considerable study. Alterations in pain sensitivity have been widely noted clinically but remain understudied and poorly understood. The ASD population may be at greater risk for having their pain undermanaged, especially in children with impaired cognitive ability and limited language skills, which may affect their ability to express pain. Given that sensitivity to noxious stimuli in adolescents with ASD has not been systematically assessed, here we measured warm and cool detection thresholds and heat and cold pain thresholds in 20 high-functioning adolescents with ASD and 55 typically developing adolescents using a method-of-limits quantitative sensory testing protocol. Adolescents with ASD had a loss of sensory function for thermal detection (P < .001, both warm and cool detection thresholds) but not pain threshold (P > .05, both heat and cold pain thresholds) in comparison to controls, with no evidence for significant age or sex effects (P > .05). Intelligence quotients and symptomatology were significantly correlated with a loss of some types of thermal perception in the ASD population (ie, warm detection threshold, cool detection threshold, and heat pain threshold; P < .05). Decreased thermal sensitivity in adolescents with ASD may be associated with cognitive impairments relating to attentional deficits. Our findings are consistent with previous literature indicating an association between thermal perception and cortical thickness in brain regions involved in somatosensation, cognition, and salience detection. Further brain-imaging research is needed to determine the neural mechanisms underlying thermal perceptual deficits in adolescents with ASD.
Perspective: We report quantitative evidence for altered thermal thresholds in adolescents with ASD. Reduced sensitivity to warmth, coolness, and heat pain was related to impaired cognitive ability. Caregivers and clinicians should consider cognitive ability when assessing and managing pain in adolescents with ASD. (C) 2015 by the American Pain Society
C1 [Duerden, Emma G.; Taylor, Margot J.; Lee, Minha] Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON M5G 1X8, Canada.
[Duerden, Emma G.; Roberts, S. Wendy] Univ Toronto, Dept Paediat, Toronto, ON M5S 1A1, Canada.
[Taylor, Margot J.] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada.
[Taylor, Margot J.; Davis, Karen D.] Univ Toronto, Dept Surg, Toronto, ON, Canada.
[Duerden, Emma G.] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada.
[Taylor, Margot J.; Davis, Karen D.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
[McGrath, Patricia A.] Pain Innovat Inc, London, ON, Canada.
[Davis, Karen D.] Univ Hlth Network, Toronto Western Res Inst, Div Brain Imaging & Behav Syst Neurosci, Toronto, ON, Canada.
RP Duerden, EG (reprint author), Hosp Sick Children, Div Neurol, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM emma.duerden@sickkids.ca
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NR 55
TC 0
Z9 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
J9 J PAIN
JI J. Pain
PD MAY
PY 2015
VL 16
IS 5
BP 463
EP 471
DI 10.1016/j.jpain.2015.02.001
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CH6KA
UT WOS:000354144300007
PM 25704841
ER
PT J
AU Boulet, SL
Mehta, A
Kissin, DM
Warner, L
Kawwass, JF
Jamieson, DJ
AF Boulet, Sheree L.
Mehta, Akanksha
Kissin, Dmitry M.
Warner, Lee
Kawwass, Jennifer F.
Jamieson, Denise J.
TI Trends in Use of and Reproductive Outcomes Associated With
Intracytoplasmic Sperm Injection
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
AB Since its introduction in 1992, intracytoplasmic sperminjection (ICSI) has been increasingly used in patients without severe male factor infertility despite the lack of clear evidence of a benefit over conventional in vitro fertilization (IVF). Compared with pregnancies resulting from conventional IVF, pregnancies resulting from the use of ICSI are associated with 1.5 to 4 times increased risk of chromosomal abnormalities, birth defects, intellectual disabilities, imprinting disorders, and autism. Intracytoplasmic sperm injection is considerably more expensive than conventional IVF.
The aim of this retrospective observational study was to assess national trends and reproductive outcomes of fresh IVF cycles associated with the use of ICSI compared with conventional IVF with respect to clinical indications for ICSI use. Although only fresh embryos were transferred, it is unlikely that outcomes for frozen-thawed embryos would differ. Data were obtained from the US National Assisted Reproductive Technology Surveillance System for all fresh and ICSI cycles performed during 1996 to 2012.
The primary study outcomes were (1) trends in use of ICSI during 1996 to 2012 with respect to male factor infertility, unexplained infertility, maternal age 38 years or older, low oocyte yield (<5 oocytes retrieved), and 2 or more prior assisted reproductive technology cycles and no prior live birth, and (2) reproductive outcomes during 2008 to 2012 for conventional IVF and ICSI cycles, stratified by the presence or absence of male factor infertility.
A total of 1,395,634 fresh IVF cycles were identified between 1996 and 2012; 908,767 (65.1%) used ICSI, and 486,867 cycles (34.9%) used conventional IVF. Male factor infertility was identified in 499,135 (35.8%) of fresh cycles. During 2006 to 2012, ICSI use among cycles with male factor infertility increased from 76.3% (10,876/14,259) to 93.3% (32,191/34,506) (P < 0.001), whereas its use for those without male factor infertility increased from 15.4% (4,197/27,191) to 66.9% (42,321/63,250) (P < 0.001). During 2008 to 2012, 494,907 fresh IVF cycles were identified, 74.6% of which used ICSI. Male factor infertility was reported in 35.7% (176,911/494,907) of fresh cycles. The risk for multiple births among these cycles was significantly lower in those undergoing ICSI compared with conventional IVF (30.9% vs 34.2%); the adjusted relative risk (RR) was 0.87, with a 95% confidence interval (CI) of 0.83 to 0.91.
Compared with conventional IVF, ICSI use among cycles without male factor infertility (n = 317,996) was associated with lower rates of implantation (23.0% vs 25.2%; adjusted RR, 0.93; 95% CI, 0.91-0.95), live birth (36.5% vs 39.2%; adjusted RR, 0.95; 95% CI, 0.93-0.97), and multiple live births (30.1% vs 31.0%; adjusted RR, 0.93; 95% CI, 0.91-0.95).
These findings show that ICSI use among fresh IVF cycles in the United States increased from 36.4% to 76.2% between 1996 and 2012. The largest relative increase occurred in cycles without male factor infertility. The data show no improvement in postfertilization reproductive outcomes with use of ICSI over conventional IVF in the absence of male factor infertility, irrespective of male factor infertility diagnosis.
C1 [Boulet, Sheree L.; Mehta, Akanksha; Kissin, Dmitry M.; Warner, Lee; Kawwass, Jennifer F.; Jamieson, Denise J.] Emory Univ, Sch Med, Div Reprod Hlth, Ctr Dis Control & Prevent, Atlanta, GA 30322 USA.
[Mehta, Akanksha] Emory Univ, Sch Med, Dept Urol, Atlanta, GA USA.
[Kissin, Dmitry M.; Kawwass, Jennifer F.; Jamieson, Denise J.] Emory Univ, Sch Med, Dept Obstet & Gynecol, Atlanta, GA USA.
RP Boulet, SL (reprint author), Emory Univ, Sch Med, Div Reprod Hlth, Ctr Dis Control & Prevent, Atlanta, GA 30322 USA.
NR 0
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD MAY
PY 2015
VL 70
IS 5
BP 325
EP 326
PG 2
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA CI4MZ
UT WOS:000354725300016
ER
PT J
AU Bernard, LP
Zhang, HY
AF Bernard, Laura P.
Zhang, Huaye
TI MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a
PKA-Dependent Mechanism
SO PLOS ONE
LA English
DT Article
ID LONG-TERM POTENTIATION; DENDRITIC SPINE MORPHOLOGY; SYNAPTIC PLASTICITY;
PROTEIN-KINASE; PHOSPHORYLATION; POLARITY; PSD-95; LKB1; NEURONS;
SYNAPTOGENESIS
AB The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs), are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA), through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.
C1 [Bernard, Laura P.; Zhang, Huaye] Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA.
RP Zhang, HY (reprint author), Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA.
EM huaye.zhang@rutgers.edu
FU National Institutes of Health grant [NS065183]; Rutgers Robert Wood
Johnson Medical School
FX This work was supported by National Institutes of Health grant NS065183
and startup funds from the Rutgers Robert Wood Johnson Medical School to
H.Z. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
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NR 46
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 1
PY 2015
VL 10
IS 5
AR e0124816
DI 10.1371/journal.pone.0124816
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CH2XA
UT WOS:000353887100057
PM 25932647
ER
PT J
AU Stanton-Chapman, TL
Brown, TS
AF Stanton-Chapman, Tina L.
Brown, Tiara S.
TI A Strategy to Increase the Social Interactions of 3-Year-Old Children
With Disabilities in an Inclusive Classroom
SO TOPICS IN EARLY CHILDHOOD SPECIAL EDUCATION
LA English
DT Article
DE developmental delay; disability populations; peer-mediated; intervention
strategies; social skills; peer interactions; play
ID HEAD-START CHILDREN; PRESCHOOL-CHILDREN; PRETEND PLAY; COMMUNICATION
INTERVENTION; LANGUAGE IMPAIRMENT; PEER INTERVENTION; SPECIAL-EDUCATION;
AUTISM; SKILLS
AB The current study evaluated the play behaviors of children with disabilities (e.g., developmental delays, specific language impairment) who participated in a social communication intervention targeting skills such as initiations, responses, name use, proximity, and turn-taking. Three children who were enrolled in an inclusive classroom met the inclusion criteria. A multiple baseline design was used to determine the effects of the intervention. The social communication intervention was highly effective for all children in increasing the rate of parallel play behaviors. Several implications for practice were derived from the findings. By teaching children social communication strategies, the quality of social interactions that children have with their peers is likely to improve. The intervention offers a more systematic technique for teaching social communication and play skills than do informal strategies commonly used by teachers. Social validity assessments indicated that teachers found the intervention acceptable and produced important changes in behavior.
C1 [Stanton-Chapman, Tina L.; Brown, Tiara S.] Univ Virginia, Charlottesville, VA 22904 USA.
RP Stanton-Chapman, TL (reprint author), Univ Virginia, Curry Sch Educ, POB 400273,417 Emmet St South, Charlottesville, VA 22904 USA.
EM stantonchapman@virginia.edu
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NR 62
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0271-1214
EI 1538-4845
J9 TOP EARLY CHILD SPEC
JI Top. Early Child. Spec. Educ.
PD MAY
PY 2015
VL 35
IS 1
BP 4
EP 14
DI 10.1177/0271121414554210
PG 11
WC Education, Special
SC Education & Educational Research
GA CI1BI
UT WOS:000354474800001
ER
PT J
AU Lieberman-Betz, RG
AF Lieberman-Betz, Rebecca G.
TI A Systematic Review of Fidelity of Implementation in Parent-Mediated
Early Communication Intervention
SO TOPICS IN EARLY CHILDHOOD SPECIAL EDUCATION
LA English
DT Review
DE intervention; families; training; parents; communication/language;
intervention strategies; parent-child interaction
ID RANDOMIZED CONTROLLED-TRIAL; AUTISM SPECTRUM DISORDERS; YOUNG-CHILDREN;
LANGUAGE INTERVENTION; DEVELOPMENTAL DELAYS; TREATMENT INTEGRITY;
PRESCHOOL-CHILDREN; TEACHING PARENTS; JOINT ATTENTION; SUPPORT
STRATEGIES
AB This article examined the reporting of four elements of fidelity of implementation (FOI) in parent-mediated early communication treatment studies. Thirty-five studies were reviewed to extract information regarding reporting of dosage, adherence, quality, and participant responsiveness for both practitioners and parents involved in parent-delivered communication treatment for children birth to 6 years of age. Results indicate relatively low reporting practices across the four elements of FOI for both practitioners and parents. Most studies (71%) reported dosage at the practitioner level (e.g., number and length of parent-training sessions), while few studies (14%) reported dosage at the parent level (i.e., amount of intervention implemented by parents outside of treatment sessions). Results also found 60% of studies reported adherence for parent implementation, but only 34% of studies reported adherence for practitioners. Implications for low reporting in the research literature, as well as recommendations for future reporting and research on FOI, are provided.
C1 [Lieberman-Betz, Rebecca G.] Univ Georgia, Athens, GA 30602 USA.
RP Lieberman-Betz, RG (reprint author), Univ Georgia, Coll Educ, Dept Commun Sci & Special Educ, 565 Aderhold Hall, Athens, GA 30602 USA.
EM rglb@uga.edu
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NR 61
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0271-1214
EI 1538-4845
J9 TOP EARLY CHILD SPEC
JI Top. Early Child. Spec. Educ.
PD MAY
PY 2015
VL 35
IS 1
BP 15
EP 27
DI 10.1177/0271121414557282
PG 13
WC Education, Special
SC Education & Educational Research
GA CI1BI
UT WOS:000354474800002
ER
PT J
AU Uddin, LQ
AF Uddin, Lucina Q.
TI Idiosyncratic connectivity in autism: developmental and anatomical
considerations
SO TRENDS IN NEUROSCIENCES
LA English
DT Editorial Material
ID SPECTRUM DISORDERS; SYMPTOM SEVERITY; CHILDREN
AB Hahamy and colleagues demonstrate individualized alterations of functional connectivity in the brains of adults with autism, suggesting that previous characterizations of general under- or over-connectivity may be overly simplistic. Adopting a developmental perspective spanning both cortical and subcortical landscapes will further clarify the nature and extent of these atypicalities.
C1 [Uddin, Lucina Q.] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
[Uddin, Lucina Q.] Univ Miami, Miller Sch Med, Neurosci Program, Miami, FL 33136 USA.
RP Uddin, LQ (reprint author), Univ Miami, Dept Psychol, POB 248185-0751, Coral Gables, FL 33124 USA.
EM Luddin@miami.edu
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NR 14
TC 0
Z9 0
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0166-2236
J9 TRENDS NEUROSCI
JI Trends Neurosci.
PD MAY
PY 2015
VL 38
IS 5
BP 261
EP 263
DI 10.1016/j.tins.2015.03.004
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA CI8TZ
UT WOS:000355045900002
PM 25841798
ER
PT J
AU Fenlon, LR
Richards, LJ
AF Fenlon, Laura R.
Richards, Linda J.
TI Contralateral targeting of the corpus callosum in normal and
pathological brain function
SO TRENDS IN NEUROSCIENCES
LA English
DT Review
DE corpus callosum; contralateral targeting; brain development; callosal
dysgenesis; autism; schizophrenia
ID AUTISM SPECTRUM DISORDERS; DEVELOPMENTAL LANGUAGE DISORDER; DEFICIT
HYPERACTIVITY DISORDER; BIOTINYLATED DEXTRAN-AMINE; DEVELOPING
CEREBRAL-CORTEX; VISUAL-CORTEX; PROJECTION NEURONS; SOMATOSENSORY
CORTEX; WHITE-MATTER; INTERHEMISPHERIC CONNECTIONS
AB The corpus callosum connects the two cortical hemispheres of the mammalian brain and is susceptible to structural defects during development, which often result in significant neuropsychological dysfunction. To date, such individuals have been studied primarily with regards to the integrity of the callosal tract at the midline. However, the mechanisms regulating the contralateral targeting of the corpus callosum, after midline crossing has occurred, are less well understood. Recent evidence suggests that defects in contralateral targeting can occur in isolation from midline-tract malformations, and may have significant functional implications. We propose that contralateral targeting is a crucially important and relatively under-investigated event in callosal development, and that defects in this process may constitute an undiagnosed phenotype in several neurological disorders.
C1 [Fenlon, Laura R.; Richards, Linda J.] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.
[Richards, Linda J.] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
RP Richards, LJ (reprint author), Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.
EM richards@uq.edu.au
FU Australian Postgraduate Award; National Health and Medical Research
Council, Australia (NHMRC) Principal Research Fellowship; NHMRC
[1029975, 1064174]
FX The authors thank Rodrigo Suarez, Rowan Tweedale, Ilan Gobius, and
Timothy J. Edwards for their comments on and discussion towards the
manuscript. L.R.F. was supported by an Australian Postgraduate Award and
L.J.R. was supported by a National Health and Medical Research Council,
Australia (NHMRC) Principal Research Fellowship. Work associated with
this article was funded by NHMRC grants 1029975 and 1064174.
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NR 119
TC 0
Z9 0
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0166-2236
J9 TRENDS NEUROSCI
JI Trends Neurosci.
PD MAY
PY 2015
VL 38
IS 5
BP 264
EP 272
DI 10.1016/j.tins.2015.02.007
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA CI8TZ
UT WOS:000355045900003
ER
PT J
AU Rutishauser, U
Mamelak, AN
Adolphs, R
AF Rutishauser, Ueli
Mamelak, Adam N.
Adolphs, Ralph
TI The primate amygdala in social perception - insights from
electrophysiological recordings and stimulation
SO TRENDS IN NEUROSCIENCES
LA English
DT Review
ID DEEP BRAIN-STIMULATION; POSTTRAUMATIC-STRESS-DISORDER; EMOTIONAL FACIAL
EXPRESSIONS; MEDIAL PREFRONTAL CORTEX; MONKEY AMYGDALA; SINGLE NEURONS;
ELECTRICAL-STIMULATION; HUMAN HIPPOCAMPUS; TEMPORAL-LOBE; QUANTITATIVE
METAANALYSIS
AB The role of the amygdala in emotion and social perception has been intensively investigated primarily through studies using functional magnetic resonance imaging (fMRI). Recently, this topic has been examined using single-unit recordings in both humans and monkeys, with a focus on face processing. The findings provide novel insights, including several surprises: amygdala neurons have very long response latencies, show highly nonlinear responses to whole faces, and can be exquisitely selective for very specific parts of faces such as the eyes. In humans, the responses of amygdala neurons correlate with internal states evoked by faces, rather than with their objective features. Current and future studies extend the investigations to psychiatric illnesses such as autism, in which atypical face processing is a hallmark of social dysfunction.
C1 [Rutishauser, Ueli; Mamelak, Adam N.] Cedars Sinai Med Ctr, Dept Neurosurg, Los Angeles, CA 90048 USA.
[Rutishauser, Ueli] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA.
[Rutishauser, Ueli; Adolphs, Ralph] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA.
[Rutishauser, Ueli] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA.
RP Rutishauser, U (reprint author), Cedars Sinai Med Ctr, Dept Neurosurg, Los Angeles, CA 90048 USA.
EM ueli.rutishauser@cshs.org
FU Conte Center grant from the National Institute of Mental Health;
Gustavus and Louise Pfeiffer Research Foundation
FX We thank Mike Tyszka for preparing Figure 1B and members of the
laboratory of U.R. and R.A. for discussion. Supported in part by a Conte
Center grant from the National Institute of Mental Health (to R.A.) and
the Gustavus and Louise Pfeiffer Research Foundation (to U.R.).
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NR 100
TC 0
Z9 0
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0166-2236
J9 TRENDS NEUROSCI
JI Trends Neurosci.
PD MAY
PY 2015
VL 38
IS 5
BP 295
EP 306
DI 10.1016/j.tins.2015.03.001
PG 12
WC Neurosciences
SC Neurosciences & Neurology
GA CI8TZ
UT WOS:000355045900006
ER
PT J
AU Lipkin, WI
Anthony, SJ
AF Lipkin, W. Ian
Anthony, Simon J.
TI Virus hunting
SO VIROLOGY
LA English
DT Review
DE Virus; Diagnostics; Surveillance; Discovery
ID IDENTIFICATION; ENCEPHALITIS; INFECTION; OUTBREAK; AUTISM
AB Viral diagnosis and discovery are receiving increasing emphasis with the recognition of their importance in addressing the challenges of emerging infectious and chronic diseases, and the advent of antiviral drugs with which to reduce the morbidity and mortality of viral infections. Here we review the status of the field including the use of molecular, proteomic and immunological assays for viral detection, social media platforms for surveillance, and public health investments that may enable enhanced situational awareness and insights into the origins of zoonotic viral diseases. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Lipkin, W. Ian; Anthony, Simon J.] Columbia Univ, Ctr Infect & Immun, New York, NY USA.
RP Lipkin, WI (reprint author), Ctr Infect & Immun, 722W 168th St 17th Floor, New York, NY 10032 USA.
EM Wil2001@columbia.edu
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NR 21
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0042-6822
J9 VIROLOGY
JI Virology
PD MAY
PY 2015
VL 479
SI SI
BP 194
EP 199
DI 10.1016/j.virol.2015.02.006
PG 6
WC Virology
SC Virology
GA CI6YG
UT WOS:000354909500018
ER
PT J
AU Aguillon-Hernandez, N
Martineau, J
Roche, L
Barthelemy, C
Elian, JC
Bonnet-Brilhault, F
AF Aguillon-Hernandez, Nadia
Martineau, Joelle
Roche, Laetitia
Barthelemy, Catherine
Elian, Jean-Claude
Bonnet-Brilhault, Frederique
TI EMOTIONAL STATIC AND DYNAMIC FACES PROCESSING IN AUTISM SPECTRUM
DISORDERS AND TYPICAL DEVELOPMENT
SO ACTA PHYSIOLOGICA
LA English
DT Meeting Abstract
C1 [Aguillon-Hernandez, Nadia; Martineau, Joelle; Roche, Laetitia; Barthelemy, Catherine; Elian, Jean-Claude; Bonnet-Brilhault, Frederique] Univ Tours, UMR Inserm 930, F-37041 Tours, France.
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD MAY
PY 2015
VL 214
SU 700
SI SI
MA P-02-005
BP 23
EP 23
PG 1
WC Physiology
SC Physiology
GA CI1TY
UT WOS:000354528800067
ER
PT J
AU Sappok, T
Diefenbacher, A
Gaul, I
Bolte, S
AF Sappok, Tanja
Diefenbacher, Albert
Gaul, Isabell
Bolte, Sven
TI Validity of the Social Communication Questionnaire in Adults With
Intellectual Disabilities and Suspected Autism Spectrum Disorder
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE diagnostics; intellectual developmental disability; autism spectrum
disorders; Social Communication Questionnaire
ID DIAGNOSTIC OBSERVATION SCHEDULE; PERVASIVE DEVELOPMENTAL DISORDERS;
PRESCHOOL-CHILDREN; MENTAL-RETARDATION; ADI-R; RISK; CLASSIFICATION;
IDENTIFICATION; PREVALENCE; INSTRUMENT
AB This study examined the validity of the Social Communication Questionnaire (SCQ) to identify autism spectrum disorder (ASD) in 151 adults with intellectual disabilities (ID) in Germany. Sensitivities and specificities for ASD were 98/47% for the SCQ-current version and 92/22% for the SCQ-lifetime version. Sensitivities and specificities were increased to 89/66% and 78/48% by adjusting the recommended cut-points. The SCQ-current score correlated with the Scale for Pervasive Developmental Disorders in Mentally Retarded Persons and the Autism Diagnostic Observation Schedule, whereas the SCQ-lifetime score correlated with the Autism Diagnostic Interview-Revised. Our findings support the use of the SCQ-current version for ASD screening in adults with ID, although the SCQ-lifetime version should be used with caution in this population.
C1 [Sappok, Tanja; Diefenbacher, Albert; Gaul, Isabell] Evangel Krankenhaus Konigin Elisabeth Herzberge, Dept Psychiat Psychotherapy & Psychosomat, Berlin, Germany.
[Bolte, Sven] Karolinska Inst, Ctr Neurodev Disorders, Dept Womens & Childrens Hlth, S-10401 Stockholm, Sweden.
RP Sappok, T (reprint author), Ev Krankenhaus Konigin Elisabeth Herzberge, Dept Psychiat, Herzbergstr 79, D-10365 Berlin, Germany.
EM tanja.sappok@t-online.de
FU Swedish Research Council
FX We are grateful to the participants and their caregivers for
participating in the study and to the clinicians who helped with data
collection for standardized ASD assessments. We appreciate Manuel
Heinrich for his thorough data search of the charts, data entry, data
analysis support, and the layout of the tables and figures. We also
thank Heika Kaiser, who thoroughly performed the PDD-MRS, ADOS, and
ADI-R evaluations. Sven Bolte was supported by the Swedish Research
Council.
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NR 43
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD MAY
PY 2015
VL 120
IS 3
BP 203
EP 214
DI 10.1352/1944-7558-120.3.203
PG 12
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI2VF
UT WOS:000354604800002
PM 25928433
ER
PT J
AU McDermott, S
Hardin, JW
Royer, JA
Mann, JR
Tong, X
Ozturk, OD
Ouyang, LJ
AF McDermott, Suzanne
Hardin, James W.
Royer, Julie A.
Mann, Joshua R.
Tong, Xin
Ozturk, Orgul D.
Ouyang, Lijing
TI Emergency Department and Inpatient Hospitalizations for Young People
With Fragile X Syndrome
SO AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
LA English
DT Article
DE intellectual disability; fragile X syndrome; adolescents; health care;
health status
ID CARE SENSITIVE CONDITIONS; HEALTH-CARE; PARENT SURVEY; EPILEPSY;
TRANSITION; PREVALENCE; SEIZURES; CHILDREN; DISABILITIES; ADOLESCENTS
AB We compared hospital encounters between adolescents and young adults with fragile X syndrome (FXS) to peers with intellectual disability (ID) from other causes, autism spectrum disorder (ASD), and a comparison group without these conditions matched by gender, age, and insurance coverage. Those with FXS, ASD, or ID were more likely to have had hospital encounters. In terms of age groups, we found mental illness hospitalizations decreased during adulthood as compared to adolescence for those with FXS, and we found that for conditions unrelated to FXS (e.g., respiratory, genitourinary, gastroenteritis, and pneumonia) adolescents had higher rates of hospitalization compared to their peers with FXS, ID, or ASD. We analyzed epilepsy, common among people with FXS and designated as an ambulatory care sensitive condition that can be treated outside the hospital, and found that people with FXS, ID, and ASD had higher odds of hospitalization due to epilepsy in both age groups than did the comparison group.
C1 [McDermott, Suzanne; Hardin, James W.; Tong, Xin] Univ S Carolina, Arnold Sch Publ Hlth, Columbia, SC 29208 USA.
[Royer, Julie A.] Univ S Carolina, South Carolina Revenue & Fiscal Affairs Off, Columbia, SC 29208 USA.
[Mann, Joshua R.] Univ S Carolina, Sch Med, Columbia, SC 29208 USA.
[Ozturk, Orgul D.] Univ S Carolina, Moore Sch Business, Columbia, SC 29208 USA.
[Ouyang, Lijing] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
RP McDermott, S (reprint author), Univ S Carolina, Dept Epidemiol & Biostat, Arnold Sch Publ Hlth, 915 Greene St, Columbia, SC 29208 USA.
EM smcdermo@mailbox.sc.edu
FU Centers for Disease Control and Prevention
FX This research was supported by a cooperative agreement from the Centers
for Disease Control and Prevention. The findings and conclusions in this
report are those of the authors and do not necessarily represent the
views of the Centers for Disease Control and Prevention, the South
Carolina Budget and Control Board Division of Research and Statistics,
the South Carolina Department of Health and Human Services, the South
Carolina Public Employee Benefit Authority, the South Carolina
Department of Education, or the South Carolina Department of Social
Services.
CR Agency for Healthcare Research and Quality, 2004, AHRQ QUAL IND PREV Q
American Academy of Pediatrics American Academy of Family Physicians & American College of Physicians-American Society of Internal Medicine., 2002, PEDIATRICS, V110, P1304
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United States Census Bureau, 2005, STAT COUNT QUICKF
NR 38
TC 0
Z9 0
PU AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
PI WASHINGTON
PA 444 N CAPITOL ST, NW STE 846, WASHINGTON, DC 20001-1512 USA
SN 1944-7515
EI 1944-7558
J9 AJIDD-AM J INTELLECT
JI AJIDD-Am. J. Intellect. Dev. Disabil.
PD MAY
PY 2015
VL 120
IS 3
BP 230
EP 243
DI 10.1352/1944-7558-120.3.230
PG 14
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CI2VF
UT WOS:000354604800004
PM 25928435
ER
PT J
AU Jiang, YHV
Palm, BE
DeBolt, MC
Goh, YS
AF Jiang, Yuhong V.
Palm, Bryce E.
DeBolt, Michaela C.
Goh, Yi Shuen
TI High-Precision Visual Long-Term Memory in Children With High-Functioning
Autism
SO JOURNAL OF ABNORMAL PSYCHOLOGY
LA English
DT Article
DE autism; visual long-term memory; face memory
ID SPATIAL WORKING-MEMORY; SPECTRUM DISORDERS; FACE RECOGNITION; FAMILIAR
FACE; INTACT; CAPACITY; OBJECTS
AB Domain-general theories of autism rest on evidence that the disorder impacts not only social communication skills but also nonsocial functions such as memory. Yet recognition memory deficits have been inconsistently documented, especially for stimuli other than faces and sentences. Here we tested school-age children with high-functioning autism (ASD) and IQ, and age-matched comparison children on a visual long-term memory task involving more than 100 photographs of objects, faces, cats, houses, and abstract stimuli. Children viewed each photograph for 2 s. After a 10-min filled delay, we assessed recognition memory for object category as well as for specific exemplars. Data supported the presence of a high-capacity and high-precision visual memory in children with ASD. Both category memory and exemplar memory accuracies were above 90% for categories for which a single exemplar had been encoded. When more exemplars per category were encoded, category memory improved, but exemplar memory declined. An exception was face memory, which remained highly accurate even after many faces had been encoded. Our study provided no evidence that visual memory in general, and face memory in particular, is impaired in children with ASD.
C1 [Jiang, Yuhong V.; Palm, Bryce E.; DeBolt, Michaela C.; Goh, Yi Shuen] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA.
RP Jiang, YHV (reprint author), Univ Minnesota, Dept Psychol, S251 Elliott Hall,75 East River Rd, Minneapolis, MN 55455 USA.
EM jiang166@umn.edu
CR Ambery FZ, 2006, AUTISM, V10, P551, DOI 10.1177/1362361306068507
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NR 43
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0021-843X
EI 1939-1846
J9 J ABNORM PSYCHOL
JI J. Abnorm. Psychol.
PD MAY
PY 2015
VL 124
IS 2
BP 447
EP 456
DI 10.1037/abn0000022
PG 10
WC Psychology, Clinical; Psychology, Multidisciplinary
SC Psychology
GA CH8WP
UT WOS:000354317100021
PM 25436998
ER
PT J
AU Aman, MG
Arnold, LE
Hollway, JA
AF Aman, Michael G.
Arnold, L. Eugene
Hollway, Jill A.
TI Assessing Change in Core Autism Symptoms: Challenges for Pharmacological
Studies
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Editorial Material
ID TRIALS
C1 [Aman, Michael G.; Arnold, L. Eugene; Hollway, Jill A.] Ohio State Univ, Nisonger Ctr OCEDD, Columbus, OH 43210 USA.
RP Aman, MG (reprint author), Ohio State Univ, Psychol, Nisonger Ctr OCEDD, 1581 Dodd Dr, Columbus, OH 43210 USA.
EM Michael.Aman@osumc.edu
CR Aman MG, 2004, CNS SPECTRUMS, V9, P36
Arnold LE, 2012, J CHILD ADOL PSYCHOP, V22, P198, DOI 10.1089/cap.2011.0056
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Guy W., 1976, ECDEU ASSESSMENT MAN
Kanne SM, 2014, J AUTISM DEV DISORD, V44, P168, DOI 10.1007/s10803-013-1862-3
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Warren Z, 2011, AHRQ PUBLICATION
Weitlauf AS, 2014, AHRQ PUBLICATION
NR 11
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD MAY 1
PY 2015
VL 25
IS 4
BP 282
EP 285
DI 10.1089/cap.2015.28999.mga
PG 4
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA CI1UT
UT WOS:000354531100002
PM 25978740
ER
PT J
AU Cochran, DM
Sikoglu, EM
Hodge, SM
Edden, RAE
Foley, A
Kennedy, DN
Moore, CM
Frazier, JA
AF Cochran, David M.
Sikoglu, Elif M.
Hodge, Steven M.
Edden, Richard A. E.
Foley, Ann
Kennedy, David N.
Moore, Constance M.
Frazier, Jean A.
TI Relationship among Glutamine, gamma-Aminobutyric Acid, and Social
Cognition in Autism Spectrum Disorders
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID MAGNETIC-RESONANCE-SPECTROSCOPY; ATTENTION-DEFICIT/HYPERACTIVITY
DISORDER; MESSENGER-RNA LEVELS; GABA CONCENTRATION; PREFRONTAL CORTEX;
POSTMORTEM BRAIN; CINGULATE CORTEX; FRONTAL-CORTEX; SYSTEM;
ABNORMALITIES
AB Objective: An imbalance of excitatory and inhibitory neurotransmission in autism spectrum disorder (ASD) has been proposed. We compared glutamate (Glu), glutamine (Gln), and gamma-aminobutyric acid (GABA) levels in the anterior cingulate cortex (ACC) of 13 males with ASD and 14 typically developing (TD) males (ages 13-17), and correlated these levels with intelligence quotient (IQ) and measures of social cognition.
Methods: Social cognition was evaluated by administration of the Social Responsiveness Scale (SRS) and the Reading the Mind in the Eyes Test (RMET). We acquired proton magnetic resonance spectroscopy (H-1-MRS) data from the bilateral ACC using the single voxel point resolved spectroscopy sequence (PRESS) to quantify Glu and Gln, and Mescher-Garwood point-resolved spectroscopy sequence (MEGA-PRESS) to quantify GABA levels referenced to creatine (Cr).
Results: There were higher Gln levels (p=0.04), and lower GABA/Cre levels (p=0.09) in the ASD group than in the TD group. There was no difference in Glu levels between groups. Gln was negatively correlated with RMET score (rho=-0.62, p=0.001) and IQ (rho=-0.56, p=0.003), and positively correlated with SRS scores (rho=0.53, p=0.007). GABA/Cre levels were positively correlated with RMET score (rho=0.34, p=0.09) and IQ (rho=0.36, p=0.07), and negatively correlated with SRS score (rho=-0.34, p=0.09).
Conclusions: These data suggest an imbalance between glutamatergic neurotransmission and GABA-ergic neurotransmission in ASD. Higher Gln levels and lower GABA/Cre levels were associated with lower IQ and greater impairments in social cognition across groups.
C1 [Cochran, David M.; Sikoglu, Elif M.; Hodge, Steven M.; Foley, Ann; Kennedy, David N.; Moore, Constance M.; Frazier, Jean A.] Univ Massachusetts, Sch Med, Child & Adolescent NeuroDev Initiat, Worcester, MA 01655 USA.
[Cochran, David M.; Sikoglu, Elif M.; Hodge, Steven M.; Foley, Ann; Kennedy, David N.; Moore, Constance M.; Frazier, Jean A.] Univ Massachusetts, Sch Med, Dept Psychiat, Worcester, MA 01655 USA.
[Sikoglu, Elif M.; Moore, Constance M.] Univ Massachusetts, Sch Med, Ctr Comparat NeuroImaging, Worcester, MA 01655 USA.
[Edden, Richard A. E.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Edden, Richard A. E.] Kennedy Krieger Inst, M Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA.
[Moore, Constance M.] Univ Massachusetts, Sch Med, Dept Radiol, Worcester, MA 01655 USA.
[Frazier, Jean A.] Univ Massachusetts, Sch Med, Dept Pediat, Worcester, MA 01655 USA.
RP Cochran, DM (reprint author), Univ Massachusetts, Sch Med, Dept Psychiat, 55 Lake Ave N,S7-434, Worcester, MA 01655 USA.
EM david.cochran@umassmemorial.org
FU American Psychiatric Institute for Research and Education; Janssen
Pharmaceutica; American Academy of Child and Adolescent Psychiatry
(AACAP) Pilot Research Award; University of Massachusetts Medical School
Department of Psychiatry Career Development and Research Office award;
UMASS Intellectual and Developmental Disabilities Research Center
(National Institutes of Health [NIH]/National Institute of Child Health
and Human Development [NICHD]) [5P30 HD004147-39]; National Institute of
Mental Health (NIMH) [MH073998]; University of Massachusetts Medical
School; NIH [R01 EB016089, P41 EB015909]
FX This work was supported by a grant from the American Psychiatric
Institute for Research and Education and Janssen Pharmaceutica, an
American Academy of Child and Adolescent Psychiatry (AACAP) Pilot
Research Award, a University of Massachusetts Medical School Department
of Psychiatry Career Development and Research Office award, the UMASS
Intellectual and Developmental Disabilities Research Center (National
Institutes of Health [NIH]/National Institute of Child Health and Human
Development [NICHD] 5P30 HD004147-39), National Institute of Mental
Health (NIMH) to C.M.M. (MH073998), and startup funds to C.M.M. from the
University of Massachusetts Medical School. This work applies tools
developed under NIH grants R01 EB016089 and P41 EB015909; R.A.E.E. also
received salary support from these grants. Mr. Hodge served as the
statistical expert for this research.
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Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3
Yip J, 2009, AUTISM RES, V2, P50, DOI 10.1002/aur.62
Yuksel C, 2010, BIOL PSYCHIAT, V68, P785, DOI 10.1016/j.biopsych.2010.06.016
Zhu H, 2011, MAGN RESON MED, V65, P603, DOI 10.1002/mrm.22671
NR 68
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD MAY 1
PY 2015
VL 25
IS 4
BP 314
EP 322
DI 10.1089/cap.2014.0112
PG 9
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA CI1UT
UT WOS:000354531100006
PM 25919578
ER
PT J
AU Logan, SL
Carpenter, L
Leslie, RS
Garrett-Mayer, E
Hunt, KJ
Charles, J
Nicholas, JS
AF Logan, Sarah L.
Carpenter, Laura
Leslie, R. Scott
Garrett-Mayer, Elizabeth
Hunt, Kelly J.
Charles, Jane
Nicholas, Joyce S.
TI Aberrant Behaviors and Co-occurring Conditions as Predictors of
Psychotropic Polypharmacy among Children with Autism Spectrum Disorders
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID POPULATION-BASED SURVEILLANCE; MEDICATION USE; FOSTER-CARE; DRUG-USE;
PREVALENCE; PATTERNS; IDENTIFICATION; COLLABORATION; ADHERENCE; NETWORK
AB Objectives: The purpose of this study was to identify rates and predictors of psychotropic medication polypharmacy among Medicaid-eligible children in South Carolina with autism spectrum disorder (ASD) from 2000 to 2008.
Methods: Population-based surveillance data were linked with state Medicaid records to obtain a detailed demographic, behavioral, educational, clinical, and diagnostic data set for all Medicaid-eligible 8-year-old children (n=629) who were identified and diagnosed with ASD using standardized criteria. Polypharmacy was defined as having interclass psychotropic medication claims overlapping for >= 30 consecutive days at any time during the 2-year study period. Multivariable logistic regression was used to model predictors of any polypharmacy, and for the three most common combinations.
Results: Overall, 60% (n=377) used any psychotropic medication, and 41% (n=153) of those had interclass polypharmacy. Common combinations were attention-deficit/hyperactivity disorder (ADHD) medications with an antidepressant (A/AD), antipsychotic (A/AP) or a mood stabilizer (A/MS). Black children had lower odds of any polypharmacy, as did those eligible for Medicaid because of income or being foster care versus those eligible because of disability. There were no significant associations between polypharmacy and social deficits in ASD for any combination, although children with communication deficits diagnostic of ASD had lower odds of any polypharmacy and A/AP polypharmacy. Children with argumentative, aggressive, hyperactive/impulsive, or self-injurious aberrant behaviors had higher odds of polypharmacy, as did children with diagnosed co-occurring ADHD, anxiety or mood disorders, or conduct/oppositional defiant disorder (ODD) in Medicaid records.
Conclusions: Future research is warranted to investigate how child-level factors impact combination psychotropic medication prescribing practices and outcomes in ASD.
C1 [Logan, Sarah L.] Med Univ S Carolina, Dept Healthcare Leadership & Management, Charleston, SC 29425 USA.
[Carpenter, Laura; Charles, Jane] Med Univ S Carolina, Div Dev & Behav Pediat, Dept Pediat, Charleston, SC 29425 USA.
[Leslie, R. Scott] Univ Calif San Diego, Dept Family Prevent Med, San Diego, CA 92103 USA.
[Garrett-Mayer, Elizabeth] Med Univ S Carolina, Hollings Canc Ctr, Dept Publ Hlth Sci, Charleston, SC 29425 USA.
[Hunt, Kelly J.] Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA.
[Nicholas, Joyce S.] Centra Neurosci Inst, Lynchburg, VA USA.
RP Logan, SL (reprint author), Med Univ S Carolina, Dept Healthcare Leadership & Management, 151B Rutledge Ave,Room 415, Charleston, SC 29425 USA.
EM logans@musc.edu
FU Centers for Disease Control (CDC) [CDC-RFA-DD06-601]
FX This work was supported by the Centers for Disease Control (CDC) Grant
#CDC-RFA-DD06-601.
CR Aman MG, 2005, J CHILD ADOL PSYCHOP, V15, P116, DOI 10.1089/cap.2005.15.116
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NR 46
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD MAY 1
PY 2015
VL 25
IS 4
BP 323
EP 336
DI 10.1089/cap.2013.0119
PG 14
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA CI1UT
UT WOS:000354531100007
PM 25919445
ER
PT J
AU Fiks, AG
Mayne, SL
Song, LH
Steffes, J
Liu, WW
McCarn, B
Margolis, B
Grimes, A
Gotlieb, E
Localio, R
Ross, ME
Grundmeier, RW
Wasserman, R
Leslie, LK
AF Fiks, Alexander G.
Mayne, Stephanie L.
Song, Lihai
Steffes, Jennifer
Liu, Weiwei
McCarn, Banita
Margolis, Benyamin
Grimes, Alan
Gotlieb, Edward
Localio, Russell
Ross, Michelle E.
Grundmeier, Robert W.
Wasserman, Richard
Leslie, Laurel K.
TI Changing Patterns of Alpha Agonist Medication Use in Children and
Adolescents 2009-2011
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; RANDOMIZED CONTROLLED-TRIAL; PRACTICE PARAMETER;
AGGRESSIVE-CHILDREN; TIC DISORDERS; CLONIDINE; ADHD; GUANFACINE;
EFFICACY
AB Objectives: The purpose of this study was to describe rates and patterns of long- and short-acting alpha agonist use for behavioral problems in a primary care population following Food and Drug Administration (FDA) approval of the long-acting alpha agonists guanfacine and clonidine.
Methods: Children and adolescents 4-18 years of age, who received an alpha agonist prescription between 2009 and 2011, were identified from a sample of 45 United States primary care practices in two electronic health record-based research networks. Alpha agonist receipt was identified using National Drug Codes and medication names. The proportion of subjects receiving long- and short-acting prescriptions in each year was calculated and examined with respect to reported mental health diagnoses, and whether indications for use were on-label, had evidence from clinical trials, or had no trial evidence.
Results: In a cohort of 282,875 subjects, 27,671 (10%) received any psychotropic medication and only 4,227 subjects (1.5%) received at least one prescription for an alpha agonist, most commonly a short-acting formulation (83%). Only 20% of alpha agonist use was on-label (use of long-acting formulations for attention-deficit/hyperactivity disorder [ADHD]). Most subjects (68%) received alpha agonists for indications with evidence of efficacy from clinical trials but no FDA approval, primarily short-acting formulations for ADHD and autism; 12% received alpha agonists for diagnoses lacking randomized clinical trial evidence in children, including sleep disorders and anxiety, or for which there was no documented mental health diagnosis. Rates of long-acting alpha agonist use increased more than 20-fold from 0.2% to 4%, whereas rates of short-acting alpha agonist use grew only slightly between 2009 and 2011 from 10.6% to 11.3%.
Conclusions: Alpha agonist use was uncommon in this population, and most subjects received short-acting forms for conditions that were off-label, but with clinical trial evidence. The safety and efficacy of use for conditions, including sleep disorders and anxiety, lacking evidence from randomized trials, warrant further investigation.
C1 [Fiks, Alexander G.] Childrens Hosp Philadelphia, Pediat Res Consortium, Philadelphia, PA 19104 USA.
[Fiks, Alexander G.; Grundmeier, Robert W.] Childrens Hosp Philadelphia, Ctr Biomed Informat, Philadelphia, PA 19104 USA.
[Fiks, Alexander G.; Mayne, Stephanie L.; Song, Lihai] Childrens Hosp Philadelphia, Ctr Pediat Clin Effectiveness, Philadelphia, PA 19104 USA.
[Fiks, Alexander G.; Mayne, Stephanie L.; Song, Lihai] Childrens Hosp Philadelphia, PolicyLab, Philadelphia, PA 19104 USA.
[Fiks, Alexander G.; Steffes, Jennifer; Liu, Weiwei; McCarn, Banita; Grimes, Alan; Gotlieb, Edward; Wasserman, Richard; Leslie, Laurel K.] Amer Acad Pediat, Pediat Res Off Settings, Elk Grove Village, IL USA.
[Fiks, Alexander G.; Grundmeier, Robert W.] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Margolis, Benyamin] US Hlth Resources & Serv Adm, Maternal & Child Hlth Bur, Rockville, MD 20857 USA.
[Localio, Russell; Ross, Michelle E.] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.
[Wasserman, Richard] Univ Vermont, Coll Med, Burlington, VT USA.
[Leslie, Laurel K.] Tufts Univ, Sch Med, Boston, MA 02111 USA.
RP Fiks, AG (reprint author), Childrens Hosp Philadelphia, 3535 Market Suite,Room 1546, Philadelphia, PA 19104 USA.
EM fiks@email.chop.edu
FU Maternal and Child Health Bureau, Health Resources and Services
Administration, United States Department of Health and Human Services
(HHS) through the American Recovery and Reinvestment Act [UB5MC2O286];
American Academy of Pediatrics; Maternal and Child Health Bureau
[R40MC245943]
FX This research was supported by cooperative agreement UB5MC2O286 from the
Maternal and Child Health Bureau, Health Resources and Services
Administration, United States Department of Health and Human Services
(HHS) through the American Recovery and Reinvestment Act of 2009 and the
American Academy of Pediatrics. The research was also supported by grant
number R40MC245943 from the Maternal and Child Health Bureau. The
findings and conclusions are those of the authors and do not necessarily
represent the views of HHS or the authors' affiliated institutions.
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NR 41
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD MAY 1
PY 2015
VL 25
IS 4
BP 362
EP 367
DI 10.1089/cap.2014.0122
PG 6
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA CI1UT
UT WOS:000354531100011
PM 25919708
ER
PT J
AU Harfterkamp, M
van der Meer, D
van der Loo-Neus, G
Buitelaar, JK
Minderaa, RB
Hoekstra, PJ
AF Harfterkamp, Myriam
van der Meer, Dennis
van der Loo-Neus, Gigi
Buitelaar, Jan K.
Minderaa, Ruud B.
Hoekstra, Pieter J.
TI No Evidence for Predictors of Response to Atomoxetine Treatment of
Attention-Deficit/Hyperactivity Disorder Symptoms in Children and
Adolescents with Autism Spectrum Disorder
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Letter
ID PERVASIVE DEVELOPMENTAL DISORDERS; OPEN-LABEL; EFFICACY; ADHD;
HYPERACTIVITY; PLACEBO; SAFETY
C1 [Harfterkamp, Myriam; van der Meer, Dennis; Minderaa, Ruud B.; Hoekstra, Pieter J.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
[van der Loo-Neus, Gigi; Buitelaar, Jan K.] Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands.
[Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands.
RP Harfterkamp, M (reprint author), Univ Med Ctr Groningen, Dept Psychiat, Child & Adolescent Psychiat Ctr, Hanzepl 1, NL-9717 ER Groningen, Netherlands.
EM m.a.harfterkamp@umcg.nl
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NR 23
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD MAY 1
PY 2015
VL 25
IS 4
BP 372
EP 375
DI 10.1089/cap.2014.0142
PG 4
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA CI1UT
UT WOS:000354531100013
PM 25919900
ER
PT J
AU Raja, M
AF Raja, Michele
TI Did Mozart suffer from Asperger syndrome?
SO JOURNAL OF MEDICAL BIOGRAPHY
LA English
DT Article
ID HIGH-FUNCTIONING AUTISM; DEVELOPMENTAL DISORDER; SCATOLOGICAL DISORDER;
TOURETTE-SYNDROME; HANDEDNESS; TICS; DELUSIONS; BEHAVIOR; CHILDREN;
BELIEFS
AB The most reliable biographies of Mozart highlight elements that are compatible with current diagnostic criteria for Asperger syndrome including qualitative impairment in social interaction and stereotyped and repetitive motor mannerisms. Furthermore, numerous features are documented including difficulty in communicating his emotional state and in inferring the mental state of his interlocutors, motor clumsiness, specific skills and genius, left-handedness, special sense of humour, physical developmental abnormalities, bizarre thinking, overvalued ideas and delusions.
C1 [Raja, Michele] Santo Spirito Hosp, Psychiat Intens Care Unit, Rome, Italy.
[Raja, Michele] Hosp Med Sch Rome, Psychopharmacol & Psychiat Semeiot, Rome, Italy.
RP Raja, M (reprint author), Via Prisciano 26, I-00136 Rome, Italy.
EM michele.raja@libero.it
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NR 66
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0967-7720
EI 1758-1087
J9 J MED BIOGR
JI J. Med. Biogr.
PD MAY
PY 2015
VL 23
IS 2
BP 84
EP 92
DI 10.1177/0967772013503763
PG 9
WC History & Philosophy Of Science
SC History & Philosophy of Science
GA CI2FJ
UT WOS:000354560300003
PM 24585598
ER
PT J
AU Croft, S
Stride, C
Maughan, B
Rowe, R
AF Croft, Simone
Stride, Christopher
Maughan, Barbara
Rowe, Richard
TI Validity of the Strengths and Difficulties Questionnaire in
Preschool-Aged Children
SO PEDIATRICS
LA English
DT Article
ID PSYCHOMETRIC PROPERTIES; MEASUREMENT INVARIANCE; COMMUNITY SAMPLE; FIT
INDEXES; VERSION; PARENT; SDQ; RELIABILITY; ALPHA
AB BACKGROUND: The Strengths and Difficulties Questionnaire (SDQ) is widely used to screen for child mental health problems and measure common forms of psychopathology in 4-to 16-year-olds. Using longitudinal data, we examined the validity of a version adapted for 3-to 4-year-olds.
METHODS: We used SDQ data from 16 659 families collected by the Millennium Cohort Study, which charts the development of children born throughout the United Kingdom during 2000-2001. Parents completed the preschool SDQ when children were aged 3 and the standard SDQ at ages 5 and 7. The SDQ's internal factor structure was assessed by using confirmatory factor analysis, with a series of competing models and extensions used to determine construct, convergent, and discriminant validity and measurement invariance over time. Predictive validity was evaluated by examining the relationships of age 3 SDQ scores with age 5 diagnostic measures of attention-deficit/hyperactivity disorder, autism spectrum disorder/Asperger syndrome, and teacher-reported measures of personal, social, and emotional development.
RESULTS: Confirmatory factor analysis supported a 5-factor measurement model. Internal reliability of subscales ranged from omega = 0.66 (peer problems) to omega = 0.83 (hyperactivity). Item-factor structures revealed measurement invariance over time. Strong positive correlations between ages 3 and 5 SDQ scores were not significantly different from correlations between age 5 and 7 scores. Conduct problems and hyperactivity subscales independently predicted developmental and clinical outcomes 2 years later.
CONCLUSIONS: Satisfactory psychometric properties of the adapted preschool version affirm its utility as a screening tool to identify 3-to 4-year-olds with emotional and behavioral difficulties.
C1 [Croft, Simone; Rowe, Richard] Univ Sheffield, Dept Psychol, Sheffield S10 2TP, S Yorkshire, England.
[Stride, Christopher] Univ Sheffield, Inst Work Psychol, Sheffield S10 2TP, S Yorkshire, England.
[Maughan, Barbara] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Res Ctr, London, England.
RP Croft, S (reprint author), Univ Sheffield, Dept Psychol, Western Bank, Sheffield S10 2TP, S Yorkshire, England.
EM s.e.croft@sheffield.ac.uk
RI Rowe, Richard/B-8477-2008
FU Economic and Social Research Council [ES/J500215/1]
FX This work was supported by an Economic and Social Research Council PhD
studentship (ES/J500215/1), awarded to Ms Croft and supervised by Drs
Rowe and Stride.
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Theunissen MHC, 2013, PEDIATRICS, V131, pE446, DOI 10.1542/peds.2012-0089
NR 29
TC 0
Z9 0
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2015
VL 135
IS 5
BP E1210
EP E1219
DI 10.1542/peds.2014-2920
PG 10
WC Pediatrics
SC Pediatrics
GA CH0QX
UT WOS:000353728400012
PM 25847804
ER
PT J
AU Jo, H
Schieve, LA
Sharma, AJ
Hinkle, SN
Li, RW
Lind, JN
AF Jo, Heejoo
Schieve, Laura A.
Sharma, Andrea J.
Hinkle, Stefanie N.
Li, Ruowei
Lind, Jennifer N.
TI Maternal Prepregnancy Body Mass Index and Child Psychosocial Development
at 6 Years of Age
SO PEDIATRICS
LA English
DT Article
ID DIFFICULTIES QUESTIONNAIRE; INTELLECTUAL DISABILITY; PSYCHOMETRIC
PROPERTIES; COGNITIVE-DEVELOPMENT; WEIGHT-GAIN; PREGNANCY; OBESITY;
ASSOCIATIONS; TRENDS; RISK
AB BACKGROUND: Both obesity and developmental disabilities have increased in recent decades. Limited studies suggest associations between maternal prepregnancy obesity and child neurodevelopment.
METHODS: The Infant Feeding Practices Study II, a US nationally distributed longitudinal study of maternal health and infant health and feeding practices, was conducted from 2005 to 2007. In 2012, mothers were recontacted for information on their children's health and development. We examined associations between maternal prepregnancy BMI and child psychosocial development in 1311 mother-child pairs included in this follow-up study. Children's development was assessed by maternal report of child psychosocial difficulties from the Strengths and Difficulties Questionnaire, past developmental diagnoses, and receipt of special needs services.
RESULTS: Adjusting for sociodemographic factors, children of obese class II/III mothers (BMI > 35.0) had increased odds of emotional symptoms (adjusted odds ratio [aOR] 2.24; 95% confidence interval [CI], 1.27-3.98), peer problems (aOR 2.07; 95% CI, 1.26-3.40), total psychosocial difficulties (aOR 2.17; 95% CI, 1.24-3.77), attention-deficit/hyperactivity disorder diagnosis (aOR 4.55; 95% CI, 1.80-11.46), autism or developmental delay diagnosis (aOR 3.13; 95% CI, 1.10-8.94), receipt of speech language therapy (aOR 1.93; 95% CI, 1.18-3.15), receipt of psychological services (aOR 2.27; 95% CI, 1.09-4.73), and receipt of any special needs service (aOR 1.99; 95% CI, 1.33-2.97) compared with children of normal weight mothers (BMI 18.5-24.9). Adjustment for potential causal pathway factors including pregnancy weight gain, gestational diabetes, breastfeeding duration, postpartum depression, and child's birth weight did not substantially affect most estimates.
CONCLUSIONS: Children whose mothers were severely obese before pregnancy had increased risk for adverse developmental outcomes.
C1 [Jo, Heejoo; Schieve, Laura A.] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Li, Ruowei; Lind, Jennifer N.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA.
[Lind, Jennifer N.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA.
[Jo, Heejoo] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA.
[Sharma, Andrea J.] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30333 USA.
[Sharma, Andrea J.; Lind, Jennifer N.] US Publ Hlth Serv Commissioned Corps, Atlanta, GA USA.
[Hinkle, Stefanie N.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Intramural Populat Hlth Res, NIH, Bethesda, MD USA.
RP Jo, H (reprint author), Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS-E86, Atlanta, GA 30333 USA.
EM heejoojo@usc.edu
FU intramural research program of the Eunice Kennedy Shriver National
Institute of Child Health and Human Development, National Institutes of
Health; National Institutes of Health (NIH)
FX Supported in part by the intramural research program of the Eunice
Kennedy Shriver National Institute of Child Health and Human
Development, National Institutes of Health. Funded by the National
Institutes of Health (NIH).
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SDQ, INF RES PROF STRENGT
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World Health Organization, 2000, 894 WHO
Xu GF, 2014, J AUTISM DEV DISORD, V44, P766, DOI 10.1007/s10803-013-1928-2
NR 42
TC 0
Z9 0
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2015
VL 135
IS 5
BP E1198
EP E1209
DI 10.1542/peds.2014-3058
PG 12
WC Pediatrics
SC Pediatrics
GA CH0QX
UT WOS:000353728400011
PM 25917989
ER
PT J
AU Hoffmann, W
Heinzel-Gutenbrunner, M
Becker, K
Kamp-Becker, I
AF Hoffmann, Wiebke
Heinzel-Gutenbrunner, Monika
Becker, Katja
Kamp-Becker, Inge
TI Screening interview for early detection of high-functioning autism
spectrum disorders
SO ZEITSCHRIFT FUR KINDER-UND JUGENDPSYCHIATRIE UND PSYCHOTHERAPIE
LA German
DT Article
DE autism; Asperger syndrome; screening; diagnosis
ID SOCIAL-COMMUNICATION-QUESTIONNAIRE; OBSERVATION-SCHEDULE ADOS;
RESPONSIVENESS-SCALE; DIAGNOSING AUTISM; ASPERGER-SYNDROME;
YOUNG-CHILDREN; EARLY IDENTIFICATION; PRESCHOOL-CHILDREN; MODIFIED
CHECKLIST; TODDLERS
AB Objective: Various different questionnaires are available for the screening of autism spectrum disorders (ASD). These screening instruments show high sensitivity and are able to identify a large number of individuals with ASD, but they lack the specificity to differentiate individuals with ASD from those children and adolescents with other complex neurobehavioural disorders (such as attention-deficit/hyperactivity disorder, emotional disorders, and others), especially for those without intellectual disabilities. Method: The present study evaluates the data of 309 individuals (153 with high-functioning ASD, 156 with other psychiatric disorders, IQ > 70) to find out whether selected items of the ADI-R can be used for an economic and sensitive screening of high-functioning ASD. Results: The results show that 8 items of the ADI-R can be used to discriminate high-functioning ASD and other psychiatric disorders. A cutoff of 5 led to a sensitivity of 0.93 and a cutoff of 6 to a specificity of 0.74. Conclusion: The combination of early onset, serious abnormalities in social contact with stereotyped or compulsive-ritualized behaviour or interests can be detected with few interview questions for screening of ASD. Nevertheless, a more detailed and specific assessment in an expert setting should follow the screening process.
C1 [Hoffmann, Wiebke; Heinzel-Gutenbrunner, Monika; Becker, Katja; Kamp-Becker, Inge] Univ Marburg, Klin Kinder & Jugendpsychiat Psychosomat & Psycho, D-35039 Marburg, Germany.
RP Kamp-Becker, I (reprint author), Univ Marburg, Klin Kinder & Jugendpsychiat Psychosomat & Psycho, Hans Sachs Str 6, D-35039 Marburg, Germany.
EM kampbeck@med.uni-marburg.de
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Wall DP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043855
NR 55
TC 0
Z9 0
PU VERLAG HANS HUBER
PI BERN 9
PA LANGGASS-STRASSE 76, CH-3000 BERN 9, SWITZERLAND
SN 1422-4917
EI 1664-2880
J9 Z KINDER JUG-PSYCH
JI Z. Kinder-und Jugendpsy. Psychother.
PD MAY
PY 2015
VL 43
IS 3
BP 207
EP 219
DI 10.1024/1422-4917/a000354
PG 13
WC Psychiatry
SC Psychiatry
GA CI2OK
UT WOS:000354586700006
ER
PT J
AU Cermak, SA
Duker, LIS
Williams, ME
Lane, CJ
Dawson, ME
Borreson, AE
Polido, JC
AF Cermak, Sharon A.
Duker, Leah I. Stein
Williams, Marian E.
Lane, Christianne Joy
Dawson, Michael E.
Borreson, Ann E.
Polido, Jose C.
TI Feasibility of a Sensory-Adapted Dental Environment for Children With
Autism
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE child development disorders, pervasive; dental care; environment;
occupational therapy; sensation disorders; stress, physiological
ID HEALTH-CARE NEEDS; SPECTRUM DISORDERS; ORAL CARE; ANXIETY; ADAPTATION;
RISK
AB OBJECTIVE. To provide an example of an occupational therapy feasibility study and evaluate the implementation of a randomized controlled pilot and feasibility trial examining the impact of a sensory-adapted dental environment (SADE) to enhance oral care for children with autism spectrum disorder (ASD).
METHOD. Twenty-two children with ASD and 22 typically developing children, ages 6-12 yr, attended a dental clinic in an urban hospital. Participants completed two dental cleanings, 3-4 mo apart, one in a regular environment and one in a SADE. Feasibility outcome measures were recruitment, retention, accrual, dropout, and protocol adherence. Intervention outcome measures were physiological stress, behavioral distress, pain, and cost.
RESULTS. We successfully recruited and retained participants. Parents expressed satisfaction with re'search study participation. Dentists stated that the intervention could be incorporated in normal practice. Intervention outcome measures favored the SADE condition.
CONCLUSION. Preliminary positive benefit of SADE in children with ASD warrants moving forwa.rd with a large-scale clinical trial.
C1 [Cermak, Sharon A.] Univ So Calif, Herman Ostrow Sch Dent, Mrs TH Chan Div Occupat Sci & Occupat Therapy, Los Angeles, CA 90089 USA.
[Duker, Leah I. Stein; Borreson, Ann E.] Univ So Calif, Herman Ostrow Sch Dent, Div Occupat Sci & Occupat Therapy, Los Angeles, CA USA.
[Williams, Marian E.] Univ So Calif, Keck Sch Med, Univ Ctr Excellence Dev Disabil, Clin Pediat,Childrens Hosp Los Angeles, Los Angeles, CA 90033 USA.
[Lane, Christianne Joy] Univ So Calif, Dept Prevent Med, Div Biostat, Los Angeles, CA 90089 USA.
[Dawson, Michael E.] Univ So Calif, Dept Psychol, Dana & David Dornsife Coll Letters Arts & Sci, Los Angeles, CA 90089 USA.
[Polido, Jose C.] Univ So Calif, Childrens Hosp Los Angeles, Dent, Los Angeles, CA USA.
[Polido, Jose C.] Univ So Calif, Herman Ostrow Sch Dent, Clin Dent, Los Angeles, CA USA.
RP Cermak, SA (reprint author), Univ So Calif, Herman Ostrow Sch Dent, Mrs TH Chan Div Occupat Sci & Occupat Therapy, Los Angeles, CA 90089 USA.
EM cermak@usc.edu
FU National Institute of Dental and Craniofacial Research
[1R34DE022263-01]; University of Southern California Ostrow School of
Dentistry; Eunice Kennedy Shriver National Institute of Child Health and
Human Development of the National Institutes of Health [T32HD064578]
FX This study was funded by the National Institute of Dental and
Craniofacial Research (1R34DE022263-01; Sharon Cermak, principal
investigator), by a seed grant from the University of Southern
California Ostrow School of Dentistry, and by the Eunice Kennedy Shriver
National Institute of Child Health and Human Development of the National
Institutes of Health (T32HD064578; Florence Clark, principal
investigator). We thank the University of Southern California Mrs. T. H.
Chan Division of Occupational Science and Occupational Therapy for its
continued support; Michele Shapiro and Anat Baniel from Beit Issie
Shapiro, Ra'nana, Israel, for their original research on sensory
adaptations in the dental environment and for providing consultation
throughout this project; Trudy Mallinson for her assistance with Rasch
analysis in developing the CDBRS coding scale; Mae Aghili for her
participation and skill in performing the study dental cleanings; Irina
Zamora for assistance in confirming diagnosis of children with ASD;
Elyse Peterson and Lauren St. Hilaire for their assistance in
psychometric testing of the CDBRS, data collection, and interrater
reliability assessments of measures; and Daniela Florindez, our
bilingual research assistant. Our ClinicalTrials.gov identifier is
NCT02077985.
CR Ayres A. J., 1972, SENSORY INTEGRATION
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NR 32
TC 0
Z9 0
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
EI 1943-7676
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2015
VL 69
IS 3
DI 10.5014/ajot.2015.013714
PG 10
WC Rehabilitation
SC Rehabilitation
GA CH5JI
UT WOS:000354071500002
ER
PT J
AU Kirby, AV
Little, LM
Schultz, B
Baranek, GT
AF Kirby, Anne V.
Little, Lauren M.
Schultz, Beth
Baranek, Grace T.
TI Observational Characterization of Sensory Interests, Repetitions, and
Seeking Behaviors
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE child behavior; child development disorders, pervasive; developmental
disabilities; observation; sensation
ID AUTISM SPECTRUM DISORDERS; TYPICALLY DEVELOPING-CHILDREN;
YOUNG-CHILDREN; DEVELOPMENTAL DELAYS; PROFILE; LIFE; DISABILITIES;
MODULATION; PATTERNS; FEATURES
AB Sensory interests, repetitions; and seeking behaviors (SIRS) are common among children with autism spectrum disorder (ASD) and other developmental disabilities (DD) and involve unusual actions that intensify or reinforce a sensory experience. Researchers and practitioners typically use parent-report measures or informal clinical observations to understand the presence and nature of SIRS. In this study, we used a scoring supplement to the Sensory Processing Assessment for Young Children, an observational measure, to characterize SIRS across three groups of children those with ASD (n = 40), DD (n = 37), and typical development (n = 39). Group differences were identified in frequency and intensity of overall SIRS, complexity of SIRS, and incidence of particular types of SIRS (i.e., posturing, sighting, proprioceptive seeking, spinning). Facial affect was also explored and found to be primarily neutral during engagement in SIRS across groups. Implications for practice and future research are discussed.
C1 [Kirby, Anne V.; Schultz, Beth] Univ N Carolina, Dept Allied Hlth Sci, Div Occupat Sci & Occupat Therapy, Chapel Hill, NC 27599 USA.
[Little, Lauren M.] Univ Kansas, Med Ctr, Dept Occupat Therapy Educ, Kansas City, KS USA.
[Baranek, Grace T.] Univ N Carolina, Dept Allied Hlth Sci, Div Occupat Sci & Occupat Therapy, Res, Chapel Hill, NC USA.
RP Kirby, AV (reprint author), Univ N Carolina, Dept Allied Hlth Sci, Div Occupat Sci & Occupat Therapy, Chapel Hill, NC 27599 USA.
EM avkirby@gmail.com
FU National Institute for Child Health and Human Development [R01-HD42168]
FX This research was supported by a grant from the National Institute for
Child Health and Human Development (R01-HD42168). This study also
received core support for participant recruitment through the North
Carolina Autism Research Registry (P30-HD03110). The authors thank staff
and students at the Sensory Experiences Project as well as the families
whose participation made this study possible.
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 44
TC 0
Z9 0
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
EI 1943-7676
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2015
VL 69
IS 3
DI 10.5014/ajot.2015.015081
PG 9
WC Rehabilitation
SC Rehabilitation
GA CH5JI
UT WOS:000354071500001
ER
PT J
AU Reynolds, S
Lane, SJ
Mullen, B
AF Reynolds, Stacey
Lane, Shelly J.
Mullen, Brian
TI Effects of Deep Pressure Stimulation on Physiological Arousal
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE adaptation, physiological; arousal; autonomic nervous system; pressure;
touch
ID DEFICIT HYPERACTIVITY DISORDER; COGNITIVE-ENERGETIC MODEL; ON-TASK
BEHAVIOR; SENSORY OVERRESPONSIVITY; WEIGHTED VEST; CHILDREN; ATTENTION;
AUTISM
AB Deep pressure stimulation has been used in therapeutic practice because of the assumption that it changes physiological arousal. The purpose of this study was to test the effects of deep pressure stimulation, applied with a Vayu Vest (Therapeutic Systems), on both autonomic arousal and performance in a normative adult sample. A repeated-measures, repeated-baseline design was used with participants completing a performance test before and after deep pressure application. A convenience sample of 50 adults participated in the study. Results showed that wearing the Vayu Vest for even short periods of time reduced sympathetic arousal and non stimulus-driven electrical occurrences. Concomitant increases in parasympathetic arousal were found. Performance improvements were noted after wearing the Vayu Vest, potentially because of changes in arousal. We conclude that deep pressure stimulation is capable of eliciting changes in autonomic arousal and may be a useful modality in diagnostic groups seen by occupational therapy practitioners.
C1 [Reynolds, Stacey; Lane, Shelly J.] Virginia Commonwealth Univ, Dept Occupat Therapy, Richmond, VA 23284 USA.
[Mullen, Brian] Therapeut Syst, Amherst, MA USA.
RP Reynolds, S (reprint author), Virginia Commonwealth Univ, Dept Occupat Therapy, Richmond, VA 23284 USA.
EM reynoldsse3@vcu.edu
FU Virginia Commonwealth University's Presidential Research Quest Fund;
Virginia Commonwealth University's Kathryn Lawrence Dragas Memorial
Scholarship Fund
FX We would like to acknowledge Sara Taylor and Alison Travers, who worked
as research assistants on this project. Funding for this study was
provided by Virginia Commonwealth University's Presidential Research
Quest Fund and Kathryn Lawrence Dragas Memorial Scholarship Fund.
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NR 23
TC 0
Z9 0
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
EI 1943-7676
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD MAY-JUN
PY 2015
VL 69
IS 3
AR 6903350010
DI 10.5014/ajot.2015.015560
PG 5
WC Rehabilitation
SC Rehabilitation
GA CH5JI
UT WOS:000354071500014
ER
PT J
AU Kigar, SL
Chang, LZ
Auger, AP
AF Kigar, Stacey L.
Chang, Liza
Auger, Anthony P.
TI Gadd45b is an epigenetic regulator of juvenile social behavior and
alters local pro-inflammatory cytokine production in the rodent amygdala
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Amygdala; Gadd45b; Methylation; Epigenetics; Social play; Reelin; MeCP2;
Adra2a; Cytokines; Development
ID SPONTANEOUSLY HYPERTENSIVE-RATS; ACTIVE DNA DEMETHYLATION; ANXIETY-LIKE
BEHAVIOR; LONG-TERM-MEMORY; VASOPRESSIN EXPRESSION; PLAY-BEHAVIOR;
BRAIN; MECP2; INTERLEUKIN-6; RECEPTOR
AB Precise regulation of the epigenome during perinatal development is critical to the formation of species-typical behavior later in life. Recent data suggests that Gadd45b facilitates active DNA demethylation by recruiting proteins involved in base excision repair (BER), which will catalyze substitution of 5-methylcytosine (5mC) for an unmodified cytosine. While a role for Gadd45b has been implicated in both hippocampal and amygdalar learning tasks, to the best of our knowledge, no study has been done investigating the involvement of Gadd45b in neurodevelopmental programming of social behavior. To address this, we used a targeted siRNA delivery approach to transiently knock down Gadd45b expression in the neonatal rat amygdala. We chose to examine social behavior in the juvenile period, as social deficits associated with neurodevelopmental disorders tend to emerge in humans at an equivalent age. We find that neonatal Gadd45b knock-down results in altered juvenile social behavior and reduced expression of several genes implicated in psychiatric disorders, including methyl-CpG-binding protein 2 (MeCP2), Reelin, and brain derived neurotrophic factor (BDNF). We furthermore report a novel role for Gadd45b in the programmed expression of alpha(2)-adrenoceptor (Adra2a). Consistent with Gadd45b's role in the periphery, we also observed changes in the expression of pro-inflammatory cytokines interleukin-6 (Il-6) and interleukin-1 beta (Il-1beta) in the amygdala, which could potentially mediate or exacerbate effects of Gadd45b knockdown on the organization of social behavior. These data suggest a prominent role for Gadd45b in the epigenetic programming of complex juvenile social interactions, and may provide insight into the etiology of juvenile behavioral disorders such as ADHD, autism, and/or schizophrenia. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Kigar, Stacey L.] Univ Wisconsin, Mol & Cellular Pharmacol Program, Madison, WI 53706 USA.
[Chang, Liza; Auger, Anthony P.] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA.
[Auger, Anthony P.] Univ Wisconsin, Neurosci Training Program, Madison, WI 53706 USA.
RP Auger, AP (reprint author), 1202 W,Johnson St, Madison, WI 53706 USA.
EM apauger@wisc.edu
FU NIH [T32 GM008688]; NSF [IOS-112207]
FX This work supported by NIH #T32 GM008688 to S.L.K. and NSF IOS-112207 to
A.P.A.
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NR 57
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAY
PY 2015
VL 46
BP 60
EP 69
DI 10.1016/j.bbi.2015.02.018
PG 10
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA CH0ZO
UT WOS:000353751100009
PM 25728234
ER
PT J
AU Wu, WL
Adams, CE
Stevens, KE
Chow, KH
Freedman, R
Patterson, PH
AF Wu, Wei-Li
Adams, Catherine E.
Stevens, Karen E.
Chow, Ke-Huan
Freedman, Robert
Patterson, Paul H.
TI The interaction between maternal immune activation and alpha 7 nicotinic
acetylcholine receptor in regulating behaviors in the offspring
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Maternal immune activation (MIA); Maternal infection; Poly(I:C);
Nicotinic acetylcholine receptor alpha 7 subunit (alpha 7AChR, CHRNA7,
Chrna7); Choline supplementation; Interleukin-6 (IL-6); Schizophrenia;
Autism
ID FETAL-BRAIN-DEVELOPMENT; CHOLINE SUPPLEMENTATION; GENE-EXPRESSION; ADULT
PSYCHOPATHOLOGY; C57BL/6 SUBSTRAINS; SENSORY INHIBITION; ANIMAL-MODELS;
MOUSE; SCHIZOPHRENIA; AUTISM
AB Mutation of human chromosome 15q13.3 increases the risk for autism and schizophrenia. One of the noteworthy genes in 15q13.3 is CHRNA7, which encodes the nicotinic acetylcholine receptor alpha 7 subunit (alpha 7nAChR) associated with schizophrenia in clinical studies,and rodent models. This study investigates the role of alpha 7nAChR in maternal immune activation (MIA) mice model, a murine model of environmental risk factor for autism and schizophrenia. We provided choline, a selective alpha 7nAChR agonist among its several developmental roles, in the diet of C57BL/6N wild-type dams throughout the gestation and lactation period and induced MIA at mid-gestation. The adult offspring behavior and gene expression profile in the maternal-placental-fetal axis at mid-gestation were investigated. We found that choline supplementation prevented several MIA-induced behavioral abnormalities in the wild-type offspring. Pro-inflammatory cytokine interleukin-6 (Il6) and Chrna7 gene expression in the wild-type fetal brain were elevated by poly(I:C) injection and were suppressed by gestational choline supplementation. We further investigated the gene expression level of Il6 in Chrna7 mutant mice. We found that the basal level of Il6 was higher in Chrna7 mutant fetal brain, which suggests that alpha 7nAChR may serve an anti-inflammatory role in the fetal brain during development. Lastly, we induced MIA in Chrna7(+/-) offspring. The Chrna7(+/-) offspring were more vulnerable to MIA, with increased behavioral abnormalities. Our study shows that alpha 7nAChR modulates inflammatory response affecting the fetal brain and demonstrates its effects on offspring behavior development after MIA. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Wu, Wei-Li; Chow, Ke-Huan; Patterson, Paul H.] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA.
[Adams, Catherine E.] Denver VA Med Ctr, Denver, CO 80220 USA.
[Adams, Catherine E.; Stevens, Karen E.; Freedman, Robert] Univ Colorado, Dept Psychiat, Aurora, CO 80045 USA.
RP Wu, WL (reprint author), MC 156-29,1200 E Calif Blvd, Pasadena, CA 91125 USA.
EM wlwu@caltech.edu
FU NIH Conte Center Award, United States [NIH 5P50MH086383-04]; Autism
Speaks, United States [7670]; National Science Council, Taiwan [NSC
101-2917-I-564-039]
FX We acknowledge Laura Rodriguez for administrative assistance; Jan Ko,
Elaine Y. Hsiao and Natalia Malkova for technical assistance; Lorena C.
Sandoval, Kwan F. Lee and Jaime Rodriguez for caring for the animals.
This work was supported by NIH Conte Center Award, United States (to
P.H.P.; NIH 5P50MH086383-04), Autism Speaks, United States (to P.H.P;
#7670), and postdoctoral fellowship from National Science Council,
Taiwan (to W.-L.W.; NSC 101-2917-I-564-039).
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NR 63
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAY
PY 2015
VL 46
BP 192
EP 202
DI 10.1016/j.bbi.2015.02.005
PG 11
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA CH0ZO
UT WOS:000353751100023
PM 25683697
ER
PT J
AU Zerbo, O
Leong, A
Barcellos, L
Bernal, P
Fireman, B
Croen, LA
AF Zerbo, Ousseny
Leong, Albin
Barcellos, Lisa
Bernal, Pilar
Fireman, Bruce
Croen, Lisa A.
TI Immune mediated conditions in autism spectrum disorders
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Autism spectrum disorder; Allergies; Autoimmune disease; Asthma
ID EARLY-CHILDHOOD AUTISM; AUTOIMMUNE-DISEASES; CHILDREN; BRAIN;
PREVALENCE; PSORIASIS; AUTOANTIBODIES; IMMUNOGLOBULIN; HEALTH; ASTHMA
AB We conducted a case-control study among members of Kaiser Permanente Northern California (KPNC) born between 1980 and 2003 to determine the prevalence of immune-mediated conditions in individuals with autism, investigate whether these conditions occur more often than expected, and explore the timing of onset relative to autism diagnosis. Cases were children and young adults with at least two autism diagnoses recorded in outpatient records (n = 5565). Controls were children without autism randomly sampled at a ratio of 5 to I, matched to cases on birth year, sex, and length of KPNC membership (n = 27,825). The main outcomes - asthma, allergies, and autoimmune diseases - were identified from KPNC inpatient and outpatient databases. Chi-square tests were used to evaluate case-control differences. Allergies and autoimmune diseases were diagnosed significantly more often among children with autism than among controls (allergy: 20.6% vs. 17.7%, Crude odds ratio (OR) = 1.22, 95% confidence interval (CI) 1.13-1.31; autoimmune disease: 1% vs. 0.76%, OR = 1.36, 95% CI 1.01-1.83), and asthma was diagnosed significantly less often (13.7% vs. 15.9%; OR = 0.83, 95% CI 0.76-0.90). Psoriasis occurred more than twice as often in cases than in controls (0.34% vs. 0.15%; OR = 2.35, 95% CI 1.36-4.08). Our results support previous observations that children with autism have elevated prevalence of specific immune-related comorbidities. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Zerbo, Ousseny; Fireman, Bruce; Croen, Lisa A.] Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA.
[Leong, Albin] Kaiser Permanente No Calif, Roseville Med Ctr, Oakland, CA 94612 USA.
[Barcellos, Lisa] Univ Calif Berkeley, Sch Publ Hlth, Genet Epidemiol & Genom Lab, Div Epidemiol, Berkeley, CA 94720 USA.
[Bernal, Pilar] Kaiser Permanente No Calif, San Jose Med Ctr, Oakland, CA 94612 USA.
RP Zerbo, O (reprint author), Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA.
EM ousseny.x.zerbo@kp.org
FU Kaiser Foundation Research Institute; National Institute of
Environmental Health Sciences [3R01ES016669]
FX The work was funded in part by the Kaiser Foundation Research Institute
and Grant 3R01ES016669 from National Institute of Environmental Health
Sciences. The funder had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
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NR 36
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAY
PY 2015
VL 46
BP 232
EP 236
DI 10.1016/j.bbi.2015.02.001
PG 5
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA CH0ZO
UT WOS:000353751100027
PM 25681541
ER
PT J
AU Koch, SV
Larsen, JT
Mouridsen, SE
Bentz, M
Petersen, L
Bulik, C
Mortensen, PB
Plessen, KJ
AF Koch, Susanne V.
Larsen, Janne T.
Mouridsen, Svend E.
Bentz, Mette
Petersen, Liselotte
Bulik, Cynthia
Mortensen, Preben B.
Plessen, Kerstin J.
TI Autism spectrum disorder in individuals with anorexia nervosa and in
their first- and second-degree relatives: Danish nationwide
register-based cohort-study
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID MAJOR PSYCHIATRIC-DISORDERS; EATING-DISORDERS; RISK-FACTORS;
GENDER-DIFFERENCES; BIPOLAR DISORDER; TRAITS; ONSET; SCHIZOPHRENIA;
FAMILY; DEPRESSION
AB Background
Clinical and population-based studies report increased prevalence of autism spectrum disorders (ASD) in individuals with anorexia nervosa and in their relatives. No nationwide study has yet been published on co-occurrence of these disorders.
Aims
To investigate comorbidity of ASD in individuals with anorexia nervosa, and aggregation of ASD and anorexia nervosa in their relatives.
Method
In Danish registers we identified all individuals born in 1981-2008, their parents, and full and half siblings, and linked them to data on hospital admissions for psychiatric disorders.
Results
Risk of comorbidity of ASD in probands with anorexia nervosa and aggregation of ASD in families of anorexia nervosa probands were increased. However, the risk of comorbid and familial ASD did not differ significantly from comorbid and familial major depression or any psychiatric disorder in anorexia nervosa probands.
Conclusions
We confirm aggregation of ASD in probands with anorexia nervosa and in their relatives; however, the relationship between anorexia nervosa and ASD appears to be nonspecific. (C) The Royal College of Psychiatrists 2015.
C1 [Koch, Susanne V.; Plessen, Kerstin J.] Univ Copenhagen, Mental Hlth Ctr Child & Adolescent Psychiat, Copenhagen Reg, DK-2100 Copenhagen, Denmark.
[Koch, Susanne V.; Plessen, Kerstin J.] Univ Copenhagen, Inst Clin Med, Fac Hlth Sci, DK-2100 Copenhagen, Denmark.
[Larsen, Janne T.; Petersen, Liselotte; Mortensen, Preben B.] Univ Aarhus, Natl Ctr Register Based Res, Sch Business & Social Sci, Aarhus, Denmark.
[Larsen, Janne T.; Mortensen, Preben B.] Aarhus Univ, Lundbeck Fdn Initiat Integrat Psychiat Res, iPsych, Dept Biomed,Fac Hlth, DK-8000 Aarhus C, Denmark.
[Mouridsen, Svend E.; Bentz, Mette] Mental Hlth Ctr Child & Adolescent Psychiat, Copenhagen Reg, Copenhagen, Denmark.
[Petersen, Liselotte] Aarhus Univ, Fac Hlth, Dept Biomed, iPsych, DK-8000 Aarhus C, Denmark.
[Petersen, Liselotte] Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark.
[Bulik, Cynthia] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
[Bulik, Cynthia] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
RP Koch, SV (reprint author), Univ Copenhagen, Mental Hlth Ctr Child & Adolescent Psychiat, Lerso Pk Alle 107,1th, DK-2100 Copenhagen, Denmark.
FU Mental Health Services, Capital Region, Copenhagen, Denmark
FX Mental Health Services, Capital Region, Copenhagen, Denmark.
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World Health Organization, 1993, IDC 10 CLASS MENT BE
Zucker NL, 2007, PSYCHOL BULL, V133, P976, DOI 10.1037/0033-2909.133.6.976
NR 47
TC 1
Z9 1
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD MAY
PY 2015
VL 206
IS 5
BP 401
EP 407
DI 10.1192/bjp.bp.114.153221
PG 7
WC Psychiatry
SC Psychiatry
GA CH6PA
UT WOS:000354157300008
PM 25657359
ER
PT J
AU Staal, WG
Langen, M
van Dijk, S
Mensen, VT
Durston, S
AF Staal, Wouter G.
Langen, Marieke
van Dijk, Sarai
Mensen, Vincent T.
Durston, Sarah
TI DRD3 gene and striatum in autism spectrum disorder
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID REPETITIVE BEHAVIOR; SYMPTOMS
AB A single-nucleotide polymorphism (SNP) of the DRD3 gene (rs167771) was recently associated with autism spectrum disorders (ASD). Different polymorphisms of rs167771 corresponded to varying degrees of stereotyped behaviour. As DRD3 receptors are relatively overexpressed in the striatum, we investigated whether striatal volume was related to these polymorphisms in autism. We assessed volumes of caudate nucleus and putamen in 86 participants with ASD (mean age 15.3 years). MANCOVA showed an association between alleles of the rs167771 SNP and the volume of striatal structures. Furthermore, greater caudate nucleus volume correlated with stereotyped behaviour. These findings support a relationship between DRD3 gene SNPs, striatum and stereotyped behaviour in ASD. (C) The Royal College of Psychiatrists 2015.
C1 [Staal, Wouter G.] Radboud Univ Nijmegen, Dept Psychiat, Nijmegen Med Ctr, Karakter Ctr Child & Adolescent Psychiat, Nijmegen, Netherlands.
[Langen, Marieke; van Dijk, Sarai; Mensen, Vincent T.; Durston, Sarah] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, NICHE Lab, Utrecht, Netherlands.
RP Staal, WG (reprint author), UMC Radboud Karakter, Reimerpostlaan 12, NL-6525 GC Nijmegen, Netherlands.
EM w.staal@karakter.com
FU Brain Foundation of The Netherlands
FX The research of W.G.S. is supported by the Brain Foundation of The
Netherlands, which is a non-profit organisation
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Toma C, 2013, WORLD J BIOL PSYCHIA, V14, P516, DOI 10.3109/15622975.2011.602719
NR 14
TC 0
Z9 0
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD MAY
PY 2015
VL 206
IS 5
BP 431
EP 432
DI 10.1192/bjp.bp.114.148973
PG 2
WC Psychiatry
SC Psychiatry
GA CH6PA
UT WOS:000354157300012
PM 25792691
ER
PT J
AU Silverman, JL
Gastrell, PT
Karras, MN
Solomon, M
Crawley, JN
AF Silverman, J. L.
Gastrell, P. T.
Karras, M. N.
Solomon, M.
Crawley, J. N.
TI Cognitive Abilities on Transitive Inference Using a Novel Touchscreen
Technology for Mice
SO CEREBRAL CORTEX
LA English
DT Article
DE autism; learning; mouse model; schizophrenia; translational
ID BTBR MOUSE MODEL; NEUROSCIENCE TREATMENT RESEARCH; AUTISM SPECTRUM
DISORDERS; PRADER-WILLI-SYNDROME; PREFRONTAL CORTEX; CONJUNCTIVE
REPRESENTATIONS; ALZHEIMERS-DISEASE; IMPAIRED ATTENTION; PATTERN
SEPARATION; IMPROVE COGNITION
AB Cognitive abilities are impaired in neurodevelopmental disorders, including autism spectrum disorder (ASD) and schizophrenia. Preclinical models with strong endophenotypes relevant to cognitive dysfunctions offer a valuable resource for therapeutic development. However, improved assays to test higher order cognition are needed. We employed touchscreen technology to design a complex transitive inference (TI) assay that requires cognitive flexibility and relational learning. C57BL/6J (B6) mice with good cognitive skills and BTBR T +tf/J (BTBR), a model of ASD with cognitive deficits, were evaluated in simple and complex touchscreen assays. Both B6 and BTBR acquired visual discrimination and reversal. BTBR displayed deficits on components of TI, when 4 stimuli pairs were interspersed, which required flexible integrated knowledge. BTBR displayed impairment on the A > E inference, analogous to the A > E deficit in ASD. B6 and BTBR mice both reached criterion on the B > D comparison, unlike the B > D impairment in schizophrenia. These results demonstrate that mice are capable of complex discriminations and higher order tasks using methods and equipment paralleling those used in humans. Our discovery that a mouse model of ASD displays a TI deficit similar to humans with ASD supports the use of the touchscreen technology for complex cognitive tasks in mouse models of neurodevelopmental disorders.
C1 [Silverman, J. L.; Solomon, M.; Crawley, J. N.] Univ Calif Davis, Sch Med, Dept Psychiat & Behav Sci, MIND Inst, Sacramento, CA 95817 USA.
[Silverman, J. L.; Gastrell, P. T.; Karras, M. N.; Crawley, J. N.] NIMH, Lab Behav Neurosci, Intramural Res Program, Bethesda, MD 20892 USA.
[Solomon, M.] Univ Calif Davis, Imaging Res Ctr, Sacramento, CA 95817 USA.
RP Silverman, JL (reprint author), Univ Calif Davis, Sch Med, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
EM jill.silverman@ucdmc.ucdavis.edu
FU National Institute of Mental Health Intramural Research Program; MIND
Institute, University of California Davis School of Medicine
FX This work was supported by the National Institute of Mental Health
Intramural Research Program and the MIND Institute, University of
California Davis School of Medicine.
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NR 103
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD MAY
PY 2015
VL 25
IS 5
BP 1133
EP 1142
DI 10.1093/cercor/bht293
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA CH2EW
UT WOS:000353839500001
PM 24293564
ER
PT J
AU Meechan, DW
Rutz, HLH
Fralish, MS
Maynard, TM
Rothblat, LA
LaMantia, AS
AF Meechan, D. W.
Rutz, H. L. H.
Fralish, M. S.
Maynard, T. M.
Rothblat, L. A.
LaMantia, A. -S.
TI Cognitive Ability is Associated with Altered Medial Frontal Cortical
Circuits in the LgDel Mouse Model of 22q11.2DS
SO CEREBRAL CORTEX
LA English
DT Article
DE anterior cingulate cortex; cortical circuit disorders; interneurons;
projection neurons; reversal learning
ID DELETION SYNDROME; PREFRONTAL CORTEX; CEREBRAL-CORTEX; BASAL
PROGENITORS; WORKING-MEMORY; RETINOIC ACID; SCHIZOPHRENIA; CHILDREN;
MICE; BRAIN
AB We established a relationship between cognitive deficits and cortical circuits in the LgDel model of 22q11 Deletion Syndrome (22q11DS)-a genetic syndrome with one of the most significant risks for schizophrenia and autism. In the LgDel mouse, optimal acquisition, execution, and reversal of a visually guided discrimination task, comparable to executive function tasks in primates including humans, are compromised; however, there is significant individual variation in degree of impairment. The task relies critically on the integrity of circuits in medial anterior frontal cortical regions. Accordingly, we analyzed neuronal changes that reflect previously defined 22q11DSrelated alterations of cortical development in the medial anterior frontal cortex of the behaviorally characterized LgDel mice. Interneuron placement, synapse distribution, and projection neuron frequency are altered in this region. The magnitude of one of these changes, layer 2/ 3 projection neuron frequency, is a robust predictor of behavioral performance: it is substantially and selectively lower in animals with the most significant behavioral deficits. These results parallel correlations of volume reduction and altered connectivity in comparable cortical regions with diminished executive function in 22q11DS patients. Apparently, 22q11 deletion alters behaviorally relevant circuits in a distinct cortical region that are essential for cognitive function.
C1 [Meechan, D. W.; Fralish, M. S.; Maynard, T. M.; LaMantia, A. -S.] George Washington Univ, Dept Physiol & Pharmacol, Washington, DC 20037 USA.
[Rutz, H. L. H.; Rothblat, L. A.] George Washington Univ, Dept Psychol, Washington, DC 20037 USA.
[Meechan, D. W.; Rutz, H. L. H.; Fralish, M. S.; Maynard, T. M.; Rothblat, L. A.; LaMantia, A. -S.] George Washington Univ, GW Inst Neurosci, Washington, DC 20037 USA.
RP LaMantia, AS (reprint author), George Washington Univ, Dept Physiol & Pharmacol, Washington, DC 20037 USA.
EM lamantia@gwu.edu
FU National Institutes of Health [R01 HD042182]
FX This work was supported by the National Institutes of Health (R01
HD042182; A.-S.L.).
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NR 59
TC 0
Z9 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD MAY
PY 2015
VL 25
IS 5
BP 1143
EP 1151
DI 10.1093/cercor/bht308
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA CH2EW
UT WOS:000353839500002
PM 24217989
ER
PT J
AU Libero, LE
DeRamus, TP
Lahti, AC
Deshpande, G
Kana, RK
AF Libero, Lauren E.
DeRamus, Thomas P.
Lahti, Adrienne C.
Deshpande, Gopikrishna
Kana, Rajesh K.
TI Multimodal neuroimaging based classification of autism spectrum disorder
using anatomical, neurochemical, and white matter correlates
SO CORTEX
LA English
DT Article
DE Autism; MRI; DTI; Spectroscopy; Multimodal neuroimaging; Classification
ID HUMAN CEREBRAL-CORTEX; MAGNETIC-RESONANCE-SPECTROSCOPY; CORTICAL
THICKNESS ANALYSIS; HIGH-FUNCTIONING AUTISM; SURFACE-BASED ANALYSIS; AGE
2 YEARS; N-ACETYLASPARTATE; IN-VIVO; MINICOLUMNAR PATHOLOGY;
GEOMETRICALLY ACCURATE
AB Neuroimaging techniques, such as fMRI, structural MRI, diffusion tensor imaging (DTI), and proton magnetic resonance spectroscopy (1H-MRS) have uncovered evidence for widespread functional and anatomical brain abnormalities in autism spectrum disorder (ASD) suggesting it to be a system-wide neural systems disorder. Nevertheless, most previous studies have focused on examining one index of neuropathology through a single neuroimaging modality, and seldom using multiple modalities to examine the same cohort of individuals. The current study aims to bring together multiple brain imaging modalities (structural MRI, DTI, and 1H-MRS) to investigate the neural architecture in the same set of individuals (19 high-functioning adults with ASD and 18 typically developing (TD) peers). Morphometry analysis revealed increased cortical thickness in ASD participants, relative to typical controls, across the left cingulate, left pars opercularis of the inferior frontal gyrus, left inferior temporal cortex, and right precuneus, and reduced cortical thickness in right cuneus and right precentral gyrus. ASD adults also had reduced fractional anisotropy (FA) and increased radial diffusivity (RD) for two clusters on the forceps minor of the corpus callosum, revealed by DTI analyses. 1H-MRS results showed a reduction in the N-acetylaspartate/Creatine ratio in dorsal anterior cingulate cortex (dACC) in ASD participants. A decision tree classification analysis across the three modalities resulted in classification accuracy of 91.9% with FA, RD, and cortical thickness as key predictors. Examining the same cohort of adults with ASD and their TD peers, this study found alterations in cortical thickness, white matter (WM) connectivity, and neurochemical concentration in ASD. These findings underscore the potential for multi-modal imaging to better inform on the neural characteristics most relevant to the disorder. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Libero, Lauren E.; DeRamus, Thomas P.; Kana, Rajesh K.] Univ Alabama Birmingham, Dept Psychol, Birmingham, AL 35294 USA.
[Lahti, Adrienne C.] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35294 USA.
[Deshpande, Gopikrishna] Auburn Univ, Dept Elect & Comp Engn, MRI Res Ctr, Auburn, AL 36849 USA.
[Deshpande, Gopikrishna] Auburn Univ, Dept Psychol, Auburn, AL 36849 USA.
RP Kana, RK (reprint author), Univ Alabama Birmingham, Dept Psychol, CIRC 235G,1719 6th Ave South, Birmingham, AL 35294 USA.
EM rkana@uab.edu
FU UAB College of Arts and Sciences Interdisciplinary Innovation Award
FX This study was funded by the UAB College of Arts and Sciences
Interdisciplinary Innovation Award to RK. The authors would also like to
thank Dr. Meredith Reid and David White for their assistance with the
1H-MRS aspect of this project. The authors would also like to thank Dr.
Jason Yeatman, Dr. Franco Pestilli, Dr. Brian Wendell, and the Stanford
Vision and Imaging Science and Technology Laboratory for providing
access to the mrDiffusion and AFQ software, and their assistance with
these resources.
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PI MILANO
PA VIA PALEOCAPA 7, 20121 MILANO, ITALY
SN 0010-9452
EI 1973-8102
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PD MAY
PY 2015
VL 66
BP 46
EP 59
DI 10.1016/j.cortex.2015.02.008
PG 14
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SC Behavioral Sciences; Neurosciences & Neurology
GA CH6OS
UT WOS:000354156500004
PM 25797658
ER
PT J
AU Nicolle, A
Ropar, D
Beck, SR
AF Nicolle, Antoinette
Ropar, Danielle
Beck, Sarah R.
TI Regret and disappointment in ASD: The matter of thinking versus feeling:
A Commentary on "Feelings of Regret and Disappointment in Adults with
High-Functioning Autism" by Zalla et al., 2014
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LA English
DT Editorial Material
ID SPECTRUM DISORDER
C1 [Nicolle, Antoinette; Ropar, Danielle] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
[Beck, Sarah R.] Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England.
RP Nicolle, A (reprint author), Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England.
EM antoinette.nicolle@nottingham.ac.uk
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ID HIGH-FUNCTIONING AUTISM; CHILDREN; JUDGMENTS; ADULTS
C1 PSL Res Univ, Inst Jean Nicod, Ecole Normale Super, Dept Etud Cognit,CNRS, Paris, France.
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NR 12
TC 0
Z9 0
PU ELSEVIER MASSON
PI MILANO
PA VIA PALEOCAPA 7, 20121 MILANO, ITALY
SN 0010-9452
EI 1973-8102
J9 CORTEX
JI Cortex
PD MAY
PY 2015
VL 66
BP 163
EP 165
DI 10.1016/j.cortex.2015.01.010
PG 3
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CH6OS
UT WOS:000354156500017
PM 25732674
ER
PT J
AU Johnson, MH
Jones, EJH
Gliga, T
AF Johnson, Mark H.
Jones, Emily J. H.
Gliga, Teodora
TI Brain adaptation and alternative developmental trajectories
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
ID CRITICAL PERIOD PLASTICITY; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
AUTISM SPECTRUM DISORDERS; DIFFERENTIAL SUSCEPTIBILITY; VISUAL-CORTEX;
FRAGILE-X; NEURODEVELOPMENTAL DISORDERS; BIOLOGICAL SENSITIVITY;
HOMEOSTATIC PLASTICITY; LANGUAGE-ACQUISITION
AB Resilience and adaptation in the face of early genetic or environmental risk has become a major interest in child psychiatry over recent years. However, we still remain far from an understanding of how developing human brains as a whole adapt to the diffuse and widespread atypical synaptic function that may be characteristic of some common developmental disorders. The first part of this paper discusses four types of whole-brain adaptation in the face of early risk: redundancy, reorganization, niche construction, and adjustment of developmental rate. The second part of the paper applies these adaptation processes specifically to autism. We speculate that key features of autism may be the end result of processes of early brain adaptation, rather than the direct consequences of ongoing neural pathology.
C1 [Johnson, Mark H.; Jones, Emily J. H.; Gliga, Teodora] Univ London, London WC1E 7HX, England.
RP Johnson, MH (reprint author), Univ London, Sch Psychol, Ctr Brain & Cognit Dev, Henry Wellcome Bldg,Malet St, London WC1E 7HX, England.
EM mark.johnson@bbk.ac.uk
FU UK Medical Research Council; Simons Foundation Autism Research
Initiative; Innovative Medicines Initiative [115300]; European Union
FX The authors acknowledge core funding from the UK Medical Research
Council, the Simons Foundation Autism Research Initiative, and the
Innovative Medicines Initiative joint undertaking under Agreement
115300, resources of which are composed of financial contribution from
the European Union's Seventh Framework Programme (FP7/2009-2013) and
EFPIA companies in kind contribution.
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NR 143
TC 0
Z9 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD MAY
PY 2015
VL 27
IS 2
SI SI
BP 425
EP 442
DI 10.1017/S0954579415000073
PG 18
WC Psychology, Developmental
SC Psychology
GA CH5WR
UT WOS:000354107000007
PM 25997763
ER
PT J
AU Gandin, I
Faletra, F
Faletra, F
Carella, M
Pecile, V
Ferrero, GB
Biamino, E
Palumbo, P
Palumbo, O
Bosco, P
Romano, C
Belcaro, C
Vozzi, D
d'Adamo, AP
AF Gandin, Ilaria
Faletra, Flavio
Faletra, Francesca
Carella, Massimo
Pecile, Vanna
Ferrero, Giovanni B.
Biamino, Elisa
Palumbo, Pietro
Palumbo, Orazio
Bosco, Paolo
Romano, Corrado
Belcaro, Chiara
Vozzi, Diego
d'Adamo, Adamo P.
TI Excess of runs of homozygosity is associated with severe cognitive
impairment in intellectual disability
SO GENETICS IN MEDICINE
LA English
DT Article
DE inbreeding; intellectual disability; runs of homozygosity
ID MENTAL-RETARDATION; SEQUENCING REVEALS; DISORDERS
AB Purpose: The harmful effects of inbreeding are well known by geneticists, and several studies have already reported cases of intellectual disability caused by recessive variants in consanguineous families. Nevertheless, the effects of inbreeding on the degree of intellectual disability are still poorly investigated. Here, we present a detailed analysis of the homozygosity regions in a cohort of 612 patients with intellectual disabilities of different degrees.
Methods: We investigated (i) the runs of homozygosity distribution between syndromic and nonsyndromic ID (ii) the effect of runs of homozygosity on the ID degree, using the intelligence quotient score.
Results: Our data revealed no significant differences in the first analysis; instead we detected significantly larger runs of homozygosity stretches in severe ID compared to nonsevere ID cases (P = 0.007), together with an increase of the percentage of genome covered by runs of homozygosity (P = 0.03).
Conclusion: In accord with the recent findings regarding autism and other neurological disorders, this study reveals the important role of autosomal recessive variants in intellectual disability. The amount of homozygosity seems to modulate the degree of cognitive impairment despite the intellectual disability cause.
C1 [Gandin, Ilaria; Belcaro, Chiara; d'Adamo, Adamo P.] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
[Faletra, Flavio; Faletra, Francesca; Pecile, Vanna; Vozzi, Diego; d'Adamo, Adamo P.] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy.
[Carella, Massimo; Palumbo, Pietro; Palumbo, Orazio] IRCCS Casa Sollievo Sofferenza, Med Genet Unit, San Giovanni Rotondo, Italy.
[Ferrero, Giovanni B.; Biamino, Elisa] Univ Turin, Dept Pediat, I-10124 Turin, Italy.
[Bosco, Paolo] Oasi Inst Res Mental Retardat & Brain Aging IRCCS, Troina, Italy.
[Romano, Corrado] IRCCS Assoc Oasi Maria Santissima, Unit Pediat & Med Genet, Troina, Italy.
RP d'Adamo, AP (reprint author), Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
EM adadamo@units.it
FU [33/2011]
FX The authors thank Stefania Cappellani, Lisa Cleva, and Anna Morgan. This
study was made possible by the financial support of the Research Project
n.33/2011 "identification of new genes involved in intellectual
disability."
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NR 18
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1098-3600
EI 1530-0366
J9 GENET MED
JI Genet. Med.
PD MAY
PY 2015
VL 17
IS 5
BP 396
EP 399
DI 10.1038/gim.2014.118
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA CH5SZ
UT WOS:000354096900011
PM 25232855
ER
PT J
AU Xie, J
Owen, T
Xia, K
Singh, AV
Tou, E
Li, LY
Arduini, B
Li, HM
Wan, LQ
Callahan, B
Wang, CY
AF Xie, Jian
Owen, Timothy
Xia, Ke
Singh, Ajay Vikram
Tou, Emiley
Li, Lingyun
Arduini, Brigitte
Li, Hongmin
Wan, Leo Q.
Callahan, Brian
Wang, Chunyu
TI Zinc Inhibits Hedgehog Autoprocessing LINKING ZINC DEFICIENCY WITH
HEDGEHOG ACTIVATION
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; SONIC-HEDGEHOG; SIGNALING PATHWAY; OXIDATIVE
STRESS; CRYSTAL-STRUCTURE; PROSTATE-CANCER; TRACE-ELEMENTS; LUNG-CANCER;
CELLS; TRANSPORTER
AB Zinc is an essential trace element with wide-ranging biological functions, whereas the Hedgehog (Hh) signaling pathway plays crucial roles in both development and disease. Here we show that there is a mechanistic link between zinc and Hh signaling. The upstream activator of Hh signaling, the Hh ligand, originates from Hh autoprocessing, which converts the Hh precursor protein to the Hh ligand. In an in vitro Hh autoprocessing assay we show that zinc inhibits Hh autoprocessing with a K-i of 2 mu M. We then demonstrate that zinc inhibits Hh autoprocessing in a cellular environment with experiments in primary rat astrocyte culture. Solution NMR reveals that zinc binds the active site residues of the Hh autoprocessing domain to inhibit autoprocessing, and isothermal titration calorimetry provided the thermodynamics of the binding. In normal physiology, zinc likely acts as a negative regulator of Hh autoprocessing and inhibits the generation of Hh ligand and Hh signaling. In many diseases, zinc deficiency and elevated level of Hh ligand co-exist, including prostate cancer, lung cancer, ovarian cancer, and autism. Our data suggest a causal relationship between zinc deficiency and the overproduction of Hh ligand.
C1 [Xie, Jian; Wang, Chunyu] Rensselaer Polytech Inst, Biochem & Biophys Grad Program, Troy, NY 12180 USA.
[Xia, Ke; Li, Lingyun; Wang, Chunyu] Rensselaer Polytech Inst, Dept Chem & Chem Biol, Troy, NY 12180 USA.
[Singh, Ajay Vikram; Wan, Leo Q.] Rensselaer Polytech Inst, Dept Biomed Engn, Troy, NY 12180 USA.
[Tou, Emiley; Wang, Chunyu] Rensselaer Polytech Inst, Dept Biol Sci, Troy, NY 12180 USA.
[Xie, Jian; Arduini, Brigitte; Wan, Leo Q.; Wang, Chunyu] Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA.
[Owen, Timothy; Callahan, Brian] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA.
[Li, Hongmin] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12208 USA.
RP Wang, CY (reprint author), Rensselaer Polytech Inst, Biochem & Biophys Grad Program, Dept Chem & Chem Biol, 110 8th St, Troy, NY 12180 USA.
EM wangc5@rpi.edu
FU National Institutes of Health (NIGMS) [R01GM081408]; Department of
Defense [W81XWH-14-1-0155]
FX This work was supported, in whole or in part, by National Institutes of
Health Grant R01GM081408 (NIGMS; to C. W.). This work was also supported
in part through Department of Defense Grant W81XWH-14-1-0155 (to B. C.).
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NR 64
TC 0
Z9 0
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAY 1
PY 2015
VL 290
IS 18
BP 11591
EP 11600
DI 10.1074/jbc.M114.623264
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CH0OA
UT WOS:000353719400034
PM 25787080
ER
PT J
AU Williamson, P
Carnahan, CR
Birri, N
Swoboda, C
AF Williamson, Pamela
Carnahan, Christina R.
Birri, Nicole
Swoboda, Christopher
TI Improving Comprehension of Narrative Using Character Event Maps for High
School Students With Autism Spectrum Disorder
SO JOURNAL OF SPECIAL EDUCATION
LA English
DT Article
DE autism spectrum disorder; narrative texts; comprehension
ID HIGH-FUNCTIONING STUDENTS; SINGLE-SUBJECT RESEARCH;
READING-COMPREHENSION; LEARNING-DISABILITIES; CHILDREN; INSTRUCTION;
LANGUAGE; INTERVENTION; METAANALYSIS; INDIVIDUALS
AB Few studies examine specific interventions for increasing narrative text comprehension for students with autism spectrum disorder (ASD). However, both the cognitive reading profiles common in ASD and the focus on access to complex text for all learners suggest the need for interventions to support narrative text comprehension. Using a multiple baseline design, the current study examined the effectiveness of an intervention package that included scaffolded completion of a character event map paired with a review of the previous session's map to make a prediction about the coming chapter on the narrative text comprehension of three male adolescents with ASD. There was an immediate change in comprehension scores for all three participants during intervention. Comprehension for all participants remained high through intervention and follow-up. Implications for research and practice are addressed.
C1 [Williamson, Pamela] Univ N Carolina, Greensboro, NC 27402 USA.
[Carnahan, Christina R.; Swoboda, Christopher] Univ Cincinnati, Cincinnati, OH 45221 USA.
[Birri, Nicole] Warren Cty Educ Serv Ctr, Lebanon, NH USA.
RP Williamson, P (reprint author), Univ N Carolina, Sch Educ, Dept Specialized Educ Serv, POB 26170, Greensboro, NC 27402 USA.
EM pswilli2@uncg.edu
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NR 54
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-4669
EI 1538-4764
J9 J SPEC EDUC
JI J. Spec. Educ.
PD MAY
PY 2015
VL 49
IS 1
BP 28
EP 38
DI 10.1177/0022466914521301
PG 11
WC Education, Special
SC Education & Educational Research
GA CH4GB
UT WOS:000353990800003
ER
PT J
AU Brock, ME
Carter, EW
AF Brock, Matthew E.
Carter, Erik W.
TI Effects of a Professional Development Package to Prepare Special
Education Paraprofessionals to Implement Evidence-Based Practice
SO JOURNAL OF SPECIAL EDUCATION
LA English
DT Article
DE professional development; paraprofessionals; video modeling; coaching;
treatment fidelity
ID AUTISM SPECTRUM DISORDERS; TIME-DELAY; STUDENTS; DISABILITIES;
COMMUNICATION; PARAEDUCATORS; STRATEGIES; SETTINGS; SCIENCE
AB Although paraprofessionals have become an increasingly integral part of special education services, most paraprofessionals lack training in evidence-based instructional strategies. We used a randomized contolled experimental design to examine the efficacy of a professional development training package and its individual components to equip 25 paraprofessionals to implement constant time delay. The effect of the training package on implementation fidelity was statistically significant and large in magnitude (d = 2.67; p < .001). Video modeling and coaching components were effective, although the effect of coaching alone (d = 2.23; p < .01) was larger than video modeling alone (d = .55; p = .18). Recommendations for further refining effective professional development opportunities for special education paraprofessionals are offered along with discussion of future research needs.
C1 [Brock, Matthew E.; Carter, Erik W.] Vanderbilt Univ, Nashville, TN 37203 USA.
RP Brock, ME (reprint author), Vanderbilt Univ, Dept Special Educ, PMB 228, Nashville, TN 37203 USA.
EM matthew.e.brock@vanderbilt.edu
FU Tennessee Department of Education to Vanderbilt University (CFDA)
[84.027A]
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: Partial
support for this project was provided by a grant from the Tennessee
Department of Education to Vanderbilt University (CFDA No. 84.027A).
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NR 48
TC 1
Z9 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-4669
EI 1538-4764
J9 J SPEC EDUC
JI J. Spec. Educ.
PD MAY
PY 2015
VL 49
IS 1
BP 39
EP 51
DI 10.1177/0022466913501882
PG 13
WC Education, Special
SC Education & Educational Research
GA CH4GB
UT WOS:000353990800004
ER
PT J
AU Balakas, K
Gallaher, CS
Tilley, C
AF Balakas, Karen
Gallaher, Carol S.
Tilley, Carra
TI Optimizing Perioperative Care for CHILDREN AND ADOLESCENTS with
Challenging Behaviors
SO MCN-THE AMERICAN JOURNAL OF MATERNAL-CHILD NURSING
LA English
DT Article
DE Adaptation; Children; Developmental disabilities; Perioperative
ID AUTISM SPECTRUM DISORDERS; NEEDS; SURGERY
AB Pediatric perioperative nurses care for a wide variety of children and adolescents, some of whom have special developmental or behavioral needs. Providing care for this vulnerable population can be challenging because they may not express their level of pain or anxiety through behaviors commonly observed in typically developing children. This quality improvement project was conducted. to enhance perioperative care delivered to children with challenging behaviors and to their families. A screening tool to individualize the plan of care was developed to identify specific behaviors, triggers, and communication patterns of these children prior to hospitalization. Interventions were identified to address these behaviors that could be used by nurses, child life specialists, and occupational therapists. Partnering with parents and other members of the interprofessional healthcare team has resulted in best practice care planning for these children, ensuring a much more successful perioperative experience for patients and families. Findings from parent surveys demonstrate that by using the tool, nurses and other team members are able to minimize stressors and implement interventions specific to the child. As a result, the adaptive care planning tool has expanded beyond the perioperative area and is now being used by direct care nurses, support staff, nurse practitioners, and physicians across the organization.
C1 [Balakas, Karen] St Louis Childrens Hosp, St Louis, MO 63178 USA.
[Gallaher, Carol S.; Tilley, Carra] St Louis Childrens Hosp, Perioperat Serv, St Louis, MO 63178 USA.
RP Balakas, K (reprint author), St Louis Childrens Hosp, St Louis, MO 63178 USA.
EM KaBalakas@bjc.org
CR American Academy of Pediatrics, 2012, PEDIATRICS, V129, P1186, DOI [10.1542/peds.2012-0876, DOI 10.1542/PEDS.2012-0876]
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Tonge Andrea, 2011, AORN J, V94, P606, DOI 10.1016/j.aorn.2011.09.005
Zeitzer D., 2013, PUBLIC RELATIONS TAC, V20, P8
NR 20
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0361-929X
EI 1539-0683
J9 MCN-AM J MATERN-CHIL
JI MCN-Am. J. Matern.-Child Nurs.
PD MAY-JUN
PY 2015
VL 40
IS 3
BP 153
EP 159
DI 10.1097/NMC.0000000000000124
PG 7
WC Nursing
SC Nursing
GA CH6PO
UT WOS:000354158700005
PM 25594693
ER
PT J
AU Suzuki, AM
Griesi-Oliveira, K
Machado, CDF
Vadasz, E
Zachi, EC
Passos-Bueno, MR
Sertie, AL
AF Suzuki, A. M.
Griesi-Oliveira, K.
De Oliveira Freitas Machado, C.
Vadasz, E.
Zachi, E. C.
Passos-Bueno, M. R.
Sertie, A. L.
TI Altered mTORC1 signaling in multipotent stem cells from nearly 25% of
patients with nonsyndromic autism spectrum disorders
SO MOLECULAR PSYCHIATRY
LA English
DT Letter
C1 [Suzuki, A. M.; Griesi-Oliveira, K.; Zachi, E. C.; Passos-Bueno, M. R.] Univ Sao Paulo, Inst Biociencias, Ctr Pesquisa Genoma Humano & Celulas Tronco, Sao Paulo, Brazil.
[Griesi-Oliveira, K.; De Oliveira Freitas Machado, C.; Sertie, A. L.] Hosp lsraelita Albert Einstein, Ctr Pesquisa Expt, Sao Paulo, Brazil.
[Vadasz, E.] Univ Sao Paulo, Inst Psiquiatria, Hosp Clin, Fac Med, Sao Paulo, Brazil.
RP Suzuki, AM (reprint author), Univ Sao Paulo, Inst Biociencias, Ctr Pesquisa Genoma Humano & Celulas Tronco, Sao Paulo, Brazil.
EM andrea.sertie@einstein.br
CR Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658
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Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009
NR 10
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD MAY
PY 2015
VL 20
IS 5
BP 550
EP 552
DI 10.1038/mp.2014.175
PG 4
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA CH0JS
UT WOS:000353706400003
ER
PT J
AU Bacon, C
Schneider, M
Le Magueresse, C
Froehlich, H
Sticht, C
Gluch, C
Monyer, H
Rappold, GA
AF Bacon, C.
Schneider, M.
Le Magueresse, C.
Froehlich, H.
Sticht, C.
Gluch, C.
Monyer, H.
Rappold, G. A.
TI Brain-specific Foxp1 deletion impairs neuronal development and causes
autistic-like behaviour
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID ESSENTIAL TRANSCRIPTIONAL REGULATOR; DE-NOVO MUTATIONS; INTELLECTUAL
DISABILITY; RECOGNITION MEMORY; LANGUAGE DISORDER; SPECTRUM DISORDER;
MICE; DEFICITS; SPEECH; ABNORMALITIES
AB Neurodevelopmental disorders are multi-faceted and can lead to intellectual disability, autism spectrum disorder and language impairment. Mutations in the Forkhead box FOXP1 gene have been linked to all these disorders, suggesting that it may play a central role in various cognitive and social processes. To understand the role of Foxp1 in the context of neurodevelopment leading to alterations in cognition and behaviour, we generated mice with a brain-specific Foxp1 deletion (Nestin-Cre(Foxp1-/-) mice). The mutant mice were viable and allowed for the first time the analysis of pre- and postnatal neurodevelopmental phenotypes, which included a pronounced disruption of the developing striatum and more subtle alterations in the hippocampus. More detailed analysis in the CA1 region revealed abnormal neuronal morphogenesis that was associated with reduced excitability and an imbalance of excitatory to inhibitory input in CA1 hippocampal neurons in Nestin-Cre(Foxp1-/-) mice. Foxp1 ablation was also associated with various cognitive and social deficits, providing new insights into its behavioural importance.
C1 [Bacon, C.; Froehlich, H.; Rappold, G. A.] Heidelberg Univ, Fac Med, Dept Human Mol Genet, D-69120 Heidelberg, Germany.
[Bacon, C.; Le Magueresse, C.; Froehlich, H.; Monyer, H.; Rappold, G. A.] Heidelberg Univ, Interdisciplinary Ctr Neurosci IZN, D-69120 Heidelberg, Germany.
[Schneider, M.; Gluch, C.] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Inst Psychopharmacol,Res Grp Dev Neuropsychopharm, D-69120 Heidelberg, Germany.
[Le Magueresse, C.; Monyer, H.] Heidelberg Univ, Fac Med, Dept Clin Neurobiol, D-69120 Heidelberg, Germany.
[Le Magueresse, C.; Monyer, H.] German Canc Res Ctr, Heidelberg, Germany.
[Le Magueresse, C.] Univ Paris 06, INSERM, UMR S 839, Paris, France.
[Sticht, C.] Heidelberg Univ, Med Res Ctr, Mannheim, Germany.
RP Rappold, GA (reprint author), Heidelberg Univ, Dept Human Mol Genet, Neuenheimer Feld 366, D-69120 Heidelberg, Germany.
EM gudrun.rappold@med.uni-heidelberg.de
FU Deutsche Forschungsgemeinschaft [Ra 380/15-1]
FX We thank Professor Gunther Schutz for for providing the Cre deleter mice
and Dr Phil Tucker for the floxed Foxp1 mice. This work was supported by
a grant from the Deutsche Forschungsgemeinschaft (Ra 380/15-1). Gudrun
A. Rappold is a member of the CellNetworks Cluster of Excellence.
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NR 40
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD MAY
PY 2015
VL 20
IS 5
BP 632
EP 639
DI 10.1038/mp.2014.116
PG 8
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA CH0JS
UT WOS:000353706400014
PM 25266127
ER
PT J
AU LoParo, D
Waldman, ID
AF LoParo, D.
Waldman, I. D.
TI The oxytocin receptor gene (OXTR) is associated with autism spectrum
disorder: a meta-analysis
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; DE-NOVO MUTATIONS; GENOME-WIDE
ASSOCIATION; SOCIAL-BEHAVIOR; DIAGNOSTIC INTERVIEW; AFFILIATIVE
BEHAVIOR; ADAPTIVE-BEHAVIOR; HUMANS; EMPATHY; COMMON
AB The oxytocin receptor gene (OXTR) has been studied as a risk factor for autism spectrum disorder (ASD) owing to converging evidence from multiple levels of analysis that oxytocin (OXT) has an important role in the regulation of affiliative behavior and social bonding in both nonhuman mammals and humans. Inconsistency in the effect sizes of the OXTR variants included in association studies render it unclear whether OXTR is truly associated with ASD, and, if so, which OXTR single-nucleotide polymorphisms (SNPs) are associated. Thus, a meta-analytic review of extant studies is needed to determine whether OXTR shows association with ASD, and to elucidate which specific SNPs have a significant effect on ASD. The current meta-analysis of 16 OXTR SNPs included 3941 individuals with ASD from 11 independent samples, although analyses of each individual SNP included a subset of this total. We found significant associations between ASD and the SNPs rs7632287, rs237887, rs2268491 and rs2254298. OXTR was also significantly associated with ASD in a gene-based test. The current meta-analysis is the largest and most comprehensive investigation of the association of OXTR with ASD and the findings suggest directions for future studies of the etiology of ASD.
C1 [LoParo, D.; Waldman, I. D.] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA.
RP LoParo, D (reprint author), Emory Univ, Dept Psychol, 36 Eagle Row, Atlanta, GA 30322 USA.
EM dloparo@emory.edu
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NR 70
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD MAY
PY 2015
VL 20
IS 5
BP 640
EP 646
DI 10.1038/mp.2014.77
PG 7
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA CH0JS
UT WOS:000353706400015
PM 25092245
ER
PT J
AU Lugnegard, T
Hallerback, MU
Gillberg, C
AF Lugnegard, Tove
Hallerback, Maria Unenge
Gillberg, Christopher
TI Asperger syndrome and schizophrenia: Overlap of self-reported autistic
traits using the Autism-spectrum Quotient (AQ)
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Asperger syndrome; Autism spectrum; Autism-spectrum quotient; Autistic
traits; Schizophrenia
ID NEURODEVELOPMENTAL HYPOTHESIS; PERSONALITY-TRAITS; GENERAL-POPULATION;
DISORDERS; ADULTS; PHENOTYPE; EPIDEMIOLOGY; ASSOCIATION; EXPERIENCES;
SCHIZOTYPY
AB Background: In clinical practice, the differential diagnosis of Asperger syndrome (AS) versus schizophrenia can be a challenge. Some self-report instruments-such as the Autism-spectrum Quotient (AQ)-have been portrayed as proxies for the diagnosis of AS. However, it has not been demonstrated to what extent autistic traits-as measured by the AQ-separate AS from schizophrenia. Aim: To examine the AS-schizophrenia discriminating ability of the AQ. Method: The AQ is a 50-item self-administered questionnaire (with score range 0-50) for measuring "autistic traits" in adults. Here, it was completed by 136 individuals: 36 with schizophrenic psychosis, 51 with AS and 49 non-clinical comparison cases. A receiver operating characteristic (ROC) analysis for the total AQ score was performed to examine the discriminating power of the instrument. Result: Both individuals with schizophrenia and individuals with AS scored significantly higher on AQ than the non-clinical group. The mean total AQ score (+/- standard deviation) of the AS group (26.7 +/- 8.9; range 9-44) was significantly higher than that of the schizophrenia group (22.7 +/- 6.2; range 10-35) (P = 0.041). However, when using the full Likert scale for scoring, the difference did not reach significance. In the ROC analysis of total AQ scores for AS versus schizophrenia, the area under the curve (AUC) was 0.65 (P = 0.02). Conclusion: Although mean AQ scores separated AS and schizophrenia at a group comparison level, significant overlap of AQ scores across the two diagnostic groups clearly reduces the discriminating power of the AQ in the separation of schizophrenia from AS.
C1 [Lugnegard, Tove; Hallerback, Maria Unenge] Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Gothenburg, Sweden.
[Lugnegard, Tove] Cent Hosp Karlstad, Dept Psychiat, S-65185 Karlstad, Sweden.
[Hallerback, Maria Unenge] Cent Hosp Karlstad, Dept Child & Adolescent Psychiat, S-65185 Karlstad, Sweden.
[Gillberg, Christopher] Univ Gothenburg, Sahlgrenska Acad, Gillberg Neuropsychiat Ctr, Child & Adolescent Psychiat, Gothenburg, Sweden.
RP Lugnegard, T (reprint author), Cent Hosp Karlstad, Dept Psychiat, S-65185 Karlstad, Sweden.
EM tove.lugnegard@telia.com
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NR 43
TC 0
Z9 0
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD MAY
PY 2015
VL 69
IS 4
BP 268
EP 274
DI 10.3109/08039488.2014.972452
PG 7
WC Psychiatry
SC Psychiatry
GA CH9YG
UT WOS:000354392000005
PM 25389915
ER
PT J
AU Hassall, R
AF Hassall, Richard
TI Autism confusion
SO PSYCHOLOGIST
LA English
DT Letter
C1 Univ Sheffield, Dept Philosophy, Sheffield S10 2TN, S Yorkshire, England.
RP Hassall, R (reprint author), Univ Sheffield, Dept Philosophy, Sheffield S10 2TN, S Yorkshire, England.
CR Hacking I., 2015, PHILOS ISSUES PSYCHI
NR 1
TC 0
Z9 0
PU BRITISH PSYCHOLOGICAL SOC
PI LEICESTER
PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER LE1 7DR, LEICS, ENGLAND
SN 0952-8229
J9 PSYCHOLOGIST
JI Psychologist
PD MAY
PY 2015
VL 28
IS 5
BP 343
EP 343
PG 1
WC Psychology, Multidisciplinary
SC Psychology
GA CH3MT
UT WOS:000353935500009
ER
PT J
AU Weisberg, DS
AF Weisberg, Deena Skolnick
TI Pretend play
SO WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE
LA English
DT Review
ID OF-MIND DEVELOPMENT; MENTAL TIME-TRAVEL; YOUNG-CHILDREN; SYMBOLIC PLAY;
INDIVIDUAL-DIFFERENCES; REALITY CONFUSIONS; OBJECT PLAY; AUTISM;
PRESCHOOLERS; LANGUAGE
AB Pretend play is a form of playful behavior that involves nonliteral action. Although on the surface this activity appears to be merely for fun, recent research has discovered that children's pretend play has connections to important cognitive and social skills, such as symbolic thinking, theory of mind, and counterfactual reasoning. The current article first defines pretend play and then reviews the arguments and evidence for these three connections. Pretend play has a nonliteral correspondence to reality, hence pretending may provide children with practice with navigating symbolic relationships, which may strengthen their language skills. Pretend play and theory of mind reasoning share a focus on others' mental states in order to correctly interpret their behavior, hence pretending and theory of mind may be mutually supportive in development. Pretend play and counterfactual reasoning both involve representing nonreal states of affairs, hence pretending may facilitate children's counterfactual abilities. These connections make pretend play an important phenomenon in cognitive science: Studying children's pretend play can provide insight into these other abilities and their developmental trajectories, and thereby into human cognitive architecture and its development. WIREs Cogn Sci 2015, 6:249-261. doi: 10.1002/wcs.1341 For further resources related to this article, please visit the . Conflict of interest: The author has declared no conflicts of interest for this article.
C1 Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA.
RP Weisberg, DS (reprint author), Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA.
EM deena.weisberg@psych.upenn.edu
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NR 121
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-5078
EI 1939-5086
J9 WIRES COGN SCI
JI Wiley Interdiscip. Rev.-Cogn. Sci.
PD MAY-JUN
PY 2015
VL 6
IS 3
BP 249
EP 261
DI 10.1002/wcs.1341
PG 13
WC Psychology, Experimental
SC Psychology
GA CH2WP
UT WOS:000353886000005
ER
PT J
AU Feldman, HM
Blum, NJ
Gahman, AE
Shults, J
AF Feldman, Heidi M.
Blum, Nathan J.
Gahman, Amy E.
Shults, Justine
CA DBPNet Steering Comm
TI Diagnosis of Attention-deficit/Hyperactivity Disorder by Developmental
Pediatricians in Academic Centers: A DBPNet Study
SO ACADEMIC PEDIATRICS
LA English
DT Article
DE attention-deficit/hyperactivity disorder; comorbidity; DBPNet;
developmental-behavioral pediatrics; diagnosis; stimulants
ID CLINICAL-PRACTICE GUIDELINE; DEFICIT HYPERACTIVITY DISORDER;
PRIMARY-CARE; US CHILDREN; ADHD
AB OBJECTIVE: To describe the developmental-behavioral pediatricians (DBPs), patients, and clinical practices used in the diagnostic assessments of attention-deficit/hyperactivity disorder (ADHD) within all 12 academic medical centers comprising Developmental-Behavioral Pediatrics Research Network (DBPNet).
METHODS: Between December 2011 and June 2012, all DBPs who evaluated children with ADHD or autism spectrum disorders were asked to complete a diagnostic encounter survey form for up to 10 consecutive new cases that resulted in the diagnosis of ADHD or autism spectrum disorder. Fifty-two clinicians returned one or more forms for children diagnosed with ADHD (n = 211).
RESULTS: DBPs were generally experienced full-time academics. Children were 76.3% male, 62.3% white, 24.5% African American, and 20.7% Hispanic. Mean child age was 8.0 + 3.1 years. DBPs reviewed parent ratings of behavior in 84.4% and teacher ratings in 69.2% of cases. They reviewed or completed at least one developmental assessment in 79.2% of cases: intelligence (60.2%), academic (57.8%), fine motor or visual motor (39.3%), speech/language (34.6%), or adaptive skills (28.9%). They made the diagnosis of coexisting conditions in 82.7% of cases, including learning disabilities (31.8%), speech/language disorders (31.8%), anxiety (14.2%), externalizing disorders (10.9%), and sleep disorders (9.5%). Among 146 children not medicated before the visit, stimulant medications were initiated in 15 children (10.2%).
CONCLUSIONS: Within DBPNet, DBPs were highly likely to complete comprehensive assessments of ADHD that went beyond the requirements of primary care practice guidelines. They typically identified coexisting developmental and learning conditions. They did. not typically prescribe medication at the end of diagnostic encounters.
C1 [Feldman, Heidi M.] Stanford Univ, Dept Pediat, Palo Alto, CA 94304 USA.
[Blum, Nathan J.; Gahman, Amy E.] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
[Blum, Nathan J.; Shults, Justine] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
RP Feldman, HM (reprint author), Stanford Univ, Sch Med, Div Neonatal & Dev Med, Dept Pediat, 750 Welch Rd,Suite 315, Palo Alto, CA 94304 USA.
EM hfeldman@stanford.edu
FU Maternal Child Health Bureau (Combating Autism Act), Health Resources
and Services, Department of Health and Human Services) [UA3MC20218]
FX DBPNet is supported by cooperative agreement UA3MC20218 from the
Maternal Child Health Bureau (Combating Autism Act of 2006), Health
Resources and Services, Department of Health and Human Services (project
director, Nathan J. Blum, MD). The DBPNet Steering Committee would like
to thank the following individuals, who also contributed to the
development of the study: Daniel Coury, MD; Christopher Forrest, MD,
PhD; Connie Kasai, PhD; and Amy Kratchman, BS. In addition, we would
like to thank David Schonfeld, MD who helped initiate this study at
Cincinnati Children's Hospital Medical Center and all of the physicians
at DBPNet sites who voluntarily completed the encounter forms for this
study.
CR Perrin JM, 2001, PEDIATRICS, V108, P1033
Homer CJ, 2000, PEDIATRICS, V105, P1158
Wolraich M, 2011, PEDIATRICS, V128, P1007, DOI 10.1542/peds.2011-2654
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Blum NJ, 2012, J DEV BEHAV PEDIATR, V33, P78, DOI 10.1097/DBP.0b013e31823e05bb
Boyle CA, 2011, PEDIATRICS, V127, P1034, DOI 10.1542/peds.2010-2989
Chan E, 2005, AMBUL PEDIATR, V5, P201, DOI 10.1367/A04-054R1.1
Coletti DJ, 2012, J CHILD ADOL PSYCHOP, V22, P226, DOI 10.1089/cap.2011.0090
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NR 20
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
EI 1876-2867
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD MAY-JUN
PY 2015
VL 15
IS 3
BP 282
EP 288
PG 7
WC Pediatrics
SC Pediatrics
GA CH2MQ
UT WOS:000353859700006
PM 25441653
ER
PT J
AU Blanken, LME
Mous, SE
Ghassabian, A
Muetzel, RL
Schoemaker, NK
El Marroun, H
van der Lugt, A
Jaddoe, VWV
Hofman, A
Verhulst, FC
Tiemeier, H
White, T
AF Blanken, Laura M. E.
Mous, Sabine E.
Ghassabian, Akhgar
Muetzel, Ryan L.
Schoemaker, Nikita K.
El Marroun, Hanan
van der Lugt, Aad
Jaddoe, Vincent W. V.
Hofman, Albert
Verhulst, Frank C.
Tiemeier, Henning
White, Tonya
TI Cortical Morphology in 6-to 10-Year Old Children With Autistic Traits: A
Population-Based Neuroimaging Study
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID SUPERIOR TEMPORAL SULCUS; SURFACE-AREA; DIAGNOSTIC INTERVIEW; SPECTRUM
DISORDERS; BRAIN; THICKNESS; GYRIFICATION; CHILDHOOD; TRAJECTORIES;
NETWORK
AB Objective: Recent evidence suggests that symptoms of social impairment in autism spectrum disorder (ASD) form a spectrum that extends into the general population. However, it is unclear whether the neuroanatomy of ASD also shows a similar continuum in the general population. Therefore, the goat of the present study was to investigate the relationship between cortical morphology and autistic traits along a continuum in a large population-based sample of young children.
Method: The study included 717 children, aged 6-10 years, who are participants in the Generation R Study, a large population-based cohort. Autistic traits were measured using the Social Responsiveness Scale when the children were approximately 6 years old. High-resolution MRI was obtained, and morphological measures of the cortex, including cortical thickness and gyrification, were quantified brain-wide.
Results: Children with more autistic traits showed widespread areas of decreased gyrification. After excluding children with the highest autistic traits and confirmed ASD, the association remained present in a large cluster involving the left hemisphere temporal and precuneus regions. Comparable, but nonsignificant effects when comparing a small sample of confirmed ASD case subjects with age- and gender-matched control subjects were observed.
Conclusions: Differences in cortical morphology related to autistic traits along a continuum in a large population-based sample of school-aged children were found. Part of these differences remained after excluding the most severely affected children. These findings lend support to an extension of the neurobiology of autistic traits to the general population.
C1 [White, Tonya] Erasmus Med Ctr Sophia, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands.
Erasmus Med Ctr Sophia, Generat Study Grp R, Rotterdam, Netherlands.
Leiden Univ, Ctr Child & Family Studies, Leiden, Netherlands.
Erasmus MC, Dept Radiol, Rotterdam, Netherlands.
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
RP White, T (reprint author), Erasmus Med Ctr Sophia, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands.
EM t.white@erasmusmc.nl
FU FP7 grant Action FP-7 Health Innovation [602768]; ZonMw TOP [91211021];
Erasmus Medical Center-Rotterdam; Erasmus University Rotterdam;
Netherlands Organization for Health Research and Development (ZonMw);
Netherlands Organization for Scientific Research; Ministry of Health,
Welfare and Sport; GE Healthcare; Dutch Medical Research Council
(ZonMW); European Union Research Support FP7 Program for Pediatric
Conduct Disorder; Sophia Foundation for Scientific Research
FX Supported by the FP7 grant Action FP-7 Health Innovation 2013 (number,
602768) (to Dr. Tiemeier) and by ZonMw TOP (project number, 91211021)
(to Dr. White). The general design of the Generation R Study is
supported by the Erasmus Medical Center-Rotterdam, the Erasmus
University Rotterdam, the Netherlands Organization for Health Research
and Development (ZonMw), the Netherlands Organization for Scientific
Research, and the Ministry of Health, Welfare and Sport. The Generation
R Study is conducted by the Erasmus Medical Center in close
collaboration with the School of Law and the Faculty of Social Sciences
of the Erasmus University Rotterdam, the Municipal Health Service
Rotterdam area, the Rotterdam Homecare Foundation, and the Stichting
Trombosedienst and Artsenlaboratorium Rijnmond.Dr. van der Lugt has
received research grant support from and served on the speaker's bureau
of GE Healthcare. Dr. Verhulst receives royalties from the Dutch version
of the Achenbach System of Empirically Based Assessment. Dr. Tiemeier
has received research grant support from the Dutch Medical Research
Council (ZonMW), the European Union Research Support FP7 Program for
Pediatric Conduct Disorder, and the Sophia Foundation for Scientific
Research. All other authors report no financial relationships with
commercial interests.
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NR 39
TC 0
Z9 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD MAY
PY 2015
VL 172
IS 5
BP 479
EP 486
DI 10.1176/appi.ajp.2014.14040482
PG 8
WC Psychiatry
SC Psychiatry
GA CH2FM
UT WOS:000353841100015
PM 25585034
ER
PT J
AU Cheng, W
Rolls, ET
Gu, HG
Zhang, J
Feng, JF
AF Cheng, Wei
Rolls, Edmund T.
Gu, Huaguang
Zhang, Jie
Feng, Jianfeng
TI Autism: reduced connectivity between cortical areas involved in face
expression, theory of mind, and the sense of self
SO BRAIN
LA English
DT Article
DE Autistic spectrum disorder; behavioural neurology; neuropsychiatry
imaging social cognition; temporal lobe
ID SUPERIOR TEMPORAL SULCUS; SPECTRUM DISORDERS; FUNCTIONAL CONNECTIVITY;
SOCIAL BRAIN; CORTEX; NEURONS; MONKEY; NETWORK; PARCELLATION;
INFORMATION
AB Whole-brain voxel-based unbiased resting state functional connectivity was analysed in 418 subjects with autism and 509 matched typically developing individuals. We identified a key system in the middle temporal gyrus/superior temporal sulcus region that has reduced cortical functional connectivity (and increased with the medial thalamus), which is implicated in face expression processing involved in social behaviour. This system has reduced functional connectivity with the ventromedial prefrontal cortex, which is implicated in emotion and social communication. The middle temporal gyrus system is also implicated in theory of mind processing. We also identified in autism a second key system in the precuneus/superior parietal lobule region with reduced functional connectivity, which is implicated in spatial functions including of oneself, and of the spatial environment. It is proposed that these two types of functionality, face expression-related, and of one's self and the environment, are important components of the computations involved in theory of mind, whether of oneself or of others, and that reduced connectivity within and between these regions may make a major contribution to the symptoms of autism.
C1 [Cheng, Wei; Zhang, Jie; Feng, Jianfeng] Fudan Univ, Ctr Computat Syst Biol, Shanghai 200433, Peoples R China.
[Rolls, Edmund T.; Feng, Jianfeng] Univ Warwick, Dept Comp Sci, Coventry CV4 7AL, W Midlands, England.
[Rolls, Edmund T.] Oxford Ctr Computat Neurosci, Oxford, England.
[Gu, Huaguang] Tongji Univ, Sch Aerosp Engn & Appl Mech, Shanghai 200092, Peoples R China.
RP Feng, JF (reprint author), Univ Warwick, Dept Comp Sci, Coventry CV4 7AL, W Midlands, England.
EM Jianfeng.Feng@warwick.ac.uk
RI Gu, Huaguang/E-3562-2013; ahmed, Jamila/E-8653-2015
OI Gu, Huaguang/0000-0003-0815-1447;
FU Royal Society Wolfson Research Merit Award; National Centre for
Mathematics and Interdisciplinary Sciences (NCMIS) of the Chinese
Academy of Sciences; Key Program of National Natural Science Foundation
of China [91230201]; National High Technology Research and Development
Program of China [2015AA020507]; National Natural Science Foundation of
China [61271396, 11471081, 11101429]; National Science Foundation of
China [NSFC 61104143, 61104224]; special Funds for Major State Basic
Research Projects of China [2015CB856003]
FX J.F. is a Royal Society Wolfson Research Merit Award holder. The
research was partially supported by the National Centre for Mathematics
and Interdisciplinary Sciences (NCMIS) of the Chinese Academy of
Sciences and Key Program of National Natural Science Foundation of China
(No. 91230201); and National High Technology Research and Development
Program of China under grant No. 2015AA020507, by grants from the
National Natural Science Foundation of China Grant 61271396, 11471081
and 11101429 to W.C. J.Z. is supported by National Science Foundation of
China (NSFC 61104143 and 61104224), and special Funds for Major State
Basic Research Projects of China (2015CB856003).
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NR 46
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
EI 1460-2156
J9 BRAIN
JI Brain
PD MAY 1
PY 2015
VL 138
BP 1382
EP 1393
DI 10.1093/brain/awv051
PN 5
PG 12
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CH2DB
UT WOS:000353834100031
PM 25795704
ER
PT J
AU Khan, S
Michmizos, K
Tommerdahl, M
Ganesan, S
Kitzbichler, MG
Zetino, M
Garel, KLA
Herbert, MR
Hamalainen, MS
Kenet, T
AF Khan, Sheraz
Michmizos, Konstantinos
Tommerdahl, Mark
Ganesan, Santosh
Kitzbichler, Manfred G.
Zetino, Manuel
Garel, Keri-Lee A.
Herbert, Martha R.
Hamalainen, Matti S.
Kenet, Tal
TI Somatosensory cortex functional connectivity abnormalities in autism
show opposite trends, depending on direction and spatial scale
SO BRAIN
LA English
DT Article
DE magnetoencephalography; coherence; biomarker; steady-state;
vibrotactile; mu-rhythm; autism spectrum disorder
ID SPACE SEPARATION METHOD; SURFACE-BASED ANALYSIS; TOP-DOWN MODULATION;
SPECTRUM DISORDERS; BRAIN CONNECTIVITY; EVOKED-RESPONSES; CORTICAL
SURFACE; EEG-DATA; COORDINATE SYSTEM; MU RHYTHM
AB Functional connectivity is abnormal in autism, but the nature of these abnormalities remains elusive. Different studies, mostly using functional magnetic resonance imaging, have found increased, decreased, or even mixed pattern functional connectivity abnormalities in autism, but no unifying framework has emerged to date. We measured functional connectivity in individuals with autism and in controls using magnetoencephalography, which allowed us to resolve both the directionality (feedforward versus feedback) and spatial scale (local or long-range) of functional connectivity. Specifically, we measured the cortical response and functional connectivity during a passive 25-Hz vibrotactile stimulation in the somatosensory cortex of 20 typically developing individuals and 15 individuals with autism, all males and right-handed, aged 8-18, and the mu-rhythm during resting state in a subset of these participants (12 per group, same age range). Two major significant group differences emerged in the response to the vibrotactile stimulus. First, the 50-Hz phase locking component of the cortical response, generated locally in the primary (S1) and secondary (S2) somatosensory cortex, was reduced in the autism group (P < 0.003, corrected). Second, feedforward functional connectivity between S1 and S2 was increased in the autism group (P < 0.004, corrected). During resting state, there was no group difference in the mu-a rhythm. In contrast, the mu-beta rhythm, which has been associated with feedback connectivity, was significantly reduced in the autism group (P < 0.04, corrected). Furthermore, the strength of the mu-beta was correlated to the relative strength of 50 Hz component of the response to the vibrotactile stimulus (r = 0.78, P < 0.00005), indicating a shared aetiology for these seemingly unrelated abnormalities. These magnetoencephalography-derived measures were correlated with two different behavioural sensory processing scores (P < 0.01 and P < 0.02 for the autism group, P < 0.01 and P < 0.0001 for the typical group), with autism severity (P < 0.03), and with diagnosis (89% accuracy). A biophysically realistic computational model using data driven feedforward and feedback parameters replicated the magnetoencephalography data faithfully. The direct observation of both abnormally increased and abnormally decreased functional connectivity in autism occurring simultaneously in different functional connectivity streams, offers a potential unifying framework for the unexplained discrepancies in current findings. Given that cortical feedback, whether local or long-range, is intrinsically non-linear, while cortical feedforward is generally linear relative to the stimulus, the present results suggest decreased non-linearity alongside an increased veridical component of the cortical response in autism.
C1 [Khan, Sheraz; Michmizos, Konstantinos; Ganesan, Santosh; Kitzbichler, Manfred G.; Zetino, Manuel; Garel, Keri-Lee A.; Herbert, Martha R.; Kenet, Tal] Harvard Univ, Sch Med, Dept Neurol, MGH, Boston, MA 02115 USA.
[Khan, Sheraz; Michmizos, Konstantinos; Ganesan, Santosh; Kitzbichler, Manfred G.; Zetino, Manuel; Garel, Keri-Lee A.; Herbert, Martha R.; Hamalainen, Matti S.; Kenet, Tal] MGH MIT Harvard, AA Martinos Ctr Biomed Imaging, Boston, MA USA.
[Tommerdahl, Mark] Univ N Carolina, Dept Biomed Engn, Chapel Hill, NC USA.
[Hamalainen, Matti S.] Harvard Univ, Sch Med, Dept Radiol, MGH, Boston, MA 02115 USA.
[Hamalainen, Matti S.] Aalto Univ, Sch Sci, Dept Neurosci & Biomed Engn, Espoo, Finland.
RP Kenet, T (reprint author), Massachusetts Gen Hosp, 149 13th St CNY 2275, Charlestown, MA 02129 USA.
EM tal@nmr.mgh.harvard.edu
FU Nancy Lurie Marks Family Foundation; Autism Speaks; Simons Foundation
[SFARI 239395]; National Institute of Child Health and Development
[R01HD073254]; National Centre for Research Resources [P41EB015896];
National Institute for Biomedical Imaging and Bioengineering
[5R01EB009048]; Cognitive Rhythms Collaborative: A Discovery Network
[NFS 1042134]
FX This work was supported by grants from the Nancy Lurie Marks Family
Foundation (T.K., S.K.), Autism Speaks (T.K.), The Simons Foundation
(SFARI 239395, T.K.), The National Institute of Child Health and
Development (R01HD073254, T.K.), The National Centre for Research
Resources (P41EB015896, M.S.H.), National Institute for Biomedical
Imaging and Bioengineering (5R01EB009048, M.S.H.), and the Cognitive
Rhythms Collaborative: A Discovery Network (NFS 1042134, M.S.H.).
Article needs to be deposited in PMC.
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NR 79
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
EI 1460-2156
J9 BRAIN
JI Brain
PD MAY 1
PY 2015
VL 138
BP 1394
EP 1409
DI 10.1093/brain/awv043
PN 5
PG 16
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CH2DB
UT WOS:000353834100032
PM 25765326
ER
PT J
AU Wang, Y
Zhao, SS
Wu, Z
Feng, Y
Zhao, CS
Zhang, CD
AF Wang, Yu
Zhao, Shanshan
Wu, Zhe
Feng, Yu
Zhao, Chuansheng
Zhang, Chaodong
TI Oxytocin in the regulation of social behaviours in medial
amygdala-lesioned mice via the inhibition of the extracellular
signal-regulated kinase signalling pathway
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE autism spectrum disorder; extracellular signal-regulated kinase; medial
amygdala; N-methyl-d-Aspartate; oxytocin
ID AUTISM SPECTRUM DISORDERS; TAIL SUSPENSION TEST; ACTIVATED
PROTEIN-KINASE; MOUSE MODEL; MEMORY; CREB; ANTIDEPRESSANTS;
PROSAP1/SHANK2; CONNECTIVITY; THERAPEUTICS
AB The neuropeptide oxytocin (OXT) has been implicated in the pathophysiology of behavioural deficits among patients with autism spectrum disorder (ASD). However, the molecular mechanisms underlying its role in ASD remain unclear. In the present study, a murine model with ASD-like phenotypes was induced by intra-medial amygdala injection of N-methyl-d-aspartate, and it was used to investigate the role of OXT in behaviour regulation. Behavioural tests were performed to verify the ASD-like phenotypes of N-methyl-d-aspartate-treated mice, and the results showed that mice with bilateral medial amygdala lesions presented significant behavioural deficits, including impaired learning and memory and increased anxiety and depression. We also observed a notably decreased level of OXT in both the plasma and the hypothalamus of medial amygdala-lesioned mice, and the extracellular signal-regulated kinase (ERK) was activated. Further studies demonstrated that the administration of OXT alleviated ASD-like symptoms and significantly inhibited phosphorylation of ERK; the inhibitory effect was similar to that of U0126, an ERK signalling inhibitor. In addition, OXT administration modulated the expression of downstream proteins of the ERK signalling pathway, such as cyclic adenosine monophosphate response element binding and c-fos. Taken together, our data indicate that OXT plays an important role in ameliorating behavioural deficits in an ASD-like mouse model, which was mediated by inhibiting the ERK signalling pathway and its downstream proteins.
C1 [Wang, Yu; Zhao, Shanshan; Wu, Zhe; Feng, Yu; Zhao, Chuansheng; Zhang, Chaodong] China Med Univ, Affiliated Hosp 1, Dept Neurol, Shenyang 110001, Peoples R China.
RP Zhang, CD (reprint author), China Med Univ, Affiliated Hosp 1, Dept Neurol, 155 North Nanjing St, Shenyang 110001, Peoples R China.
EM cmu1hzhangchaodong@163.com
RI ahmed, Jamila/E-8653-2015
FU National Natural Science Foundation of China [81371456]
FX This study was supported by a grant from the National Natural Science
Foundation of China (No.: 81371456).
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NR 52
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD MAY
PY 2015
VL 42
IS 5
BP 465
EP 474
DI 10.1111/1440-1681.12378
PG 10
WC Pharmacology & Pharmacy; Physiology
SC Pharmacology & Pharmacy; Physiology
GA CG6KT
UT WOS:000353410100005
PM 25707920
ER
PT J
AU Pellanda, G
Lava, SAG
Ferrarini, A
Ramelli, GP
AF Pellanda, Giorgia
Lava, Sebastiano A. G.
Ferrarini, Alessandra
Ramelli, Gian Paolo
TI High prevalence of pathologic copy number variants detected by
chromosomal microarray in Swiss-Italian children with autism spectrum
disorders
SO EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
LA English
DT Letter
ID INTELLECTUAL DISABILITY
C1 [Pellanda, Giorgia; Lava, Sebastiano A. G.; Ferrarini, Alessandra; Ramelli, Gian Paolo] San Giovanni Hosp, Pediat Dept Southern Switzerland, CH-6500 Bellinzona, Switzerland.
[Lava, Sebastiano A. G.] Inselspital Bern, Univ Childrens Hosp, CH-3010 Bern, Switzerland.
[Lava, Sebastiano A. G.] Univ Bern, CH-3010 Bern, Switzerland.
RP Ramelli, GP (reprint author), San Giovanni Hosp, Pediat Dept Southern Switzerland, CH-6500 Bellinzona, Switzerland.
EM gianpaolo.ramelli@eoc.ch
CR Battaglia A, 2013, EUR J PAEDIATR NEURO, V17, P589, DOI 10.1016/j.ejpn.2013.04.010
Capobianco S, 2014, DEV MED CHILD NEUROL, V56, P290, DOI 10.1111/dmcn.12341
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Utine GE, 2014, EUR J PAEDIATR NEURO, V18, P327
NR 5
TC 0
Z9 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1090-3798
EI 1532-2130
J9 EUR J PAEDIATR NEURO
JI Eur. J. Paediatr. Neurol.
PD MAY
PY 2015
VL 19
IS 3
BP 386
EP 387
DI 10.1016/j.ejpn.2015.01.009
PG 2
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA CG9CM
UT WOS:000353612000021
PM 25725507
ER
PT J
AU Davidovitch, M
Levit-Binnun, N
Golan, D
Manning-Courtney, P
AF Davidovitch, Michael
Levit-Binnun, Nava
Golan, Dafna
Manning-Courtney, Patricia
TI Late Diagnosis of Autism Spectrum Disorder After Initial Negative
Assessment by a Multidisciplinary Team
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE autism; autism spectrum disorder; diagnosis; diagnostic evaluation; late
diagnosis
ID AGE; POPULATION; PREVALENCE
AB Objective: Describe a cohort of children who received a diagnosis of autism spectrum disorder (ASD) after age 6 and after having undergone a comprehensive multidisciplinary assessment before the age of 6, through which they were not diagnosed with ASD. Methods: Extensive chart review of patients' electronic medical records comprised a representative population-based registry of patients seen during 2004 to 2011. The study focused only on the cohort of children who were diagnosed with ASD after the age of 6 but were not diagnosed with ASD at an earlier age. The charts were reviewed for the number of developmental assessments completed and the clinician's diagnostic impressions. The charts were also examined for documentation of ASD-suggestive features pulled directly from the text of the evaluators' reports. Results: A total of 221 patients (189 males) were diagnosed with ASD after age 6 although their initial comprehensive developmental evaluations before the age of 6 were negative for ASD. The study cohort underwent a total of 1028 developmental evaluations before the age of 6, with initial diagnostic impressions that included language deficits (70%), motor difficulties (67%), attention problems (46%), and cognitive difficulties (42%). Less than half of the cohort had ASD-suggesting features documented in their initial assessment. Conclusions: Subsequent late diagnosis of ASD after an initial ASD-negative comprehensive assessment is a common clinical experience. Reasons for this scenario may include evolving diagnosis as well as missed and overdiagnosed cases of ASD.
C1 [Davidovitch, Michael] Maccabi Healthcare Serv, Div Med, Child Dev, IL-6812509 Tel Aviv, Israel.
[Davidovitch, Michael; Levit-Binnun, Nava] Interdisciplinary Ctr IDC, Sch Psychol, Sagol Inst Appl Neurosci, Herzliyya, Israel.
[Golan, Dafna] Maccabi Healthcare Serv, Hashfela & Jerusalem Dist, Child Dev, Jerusalem, Israel.
[Manning-Courtney, Patricia] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Div Dev & Behav Pediat, Cincinnati, OH USA.
RP Davidovitch, M (reprint author), Maccabi Healthcare Serv, Div Med, Child Dev, 27 Hamered St, IL-6812509 Tel Aviv, Israel.
EM davidom@netvision.net.il
RI ahmed, Jamila/E-8653-2015
CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 19
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD MAY
PY 2015
VL 36
IS 4
BP 227
EP 234
PG 8
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
SC Behavioral Sciences; Psychology; Pediatrics
GA CH1SZ
UT WOS:000353803100001
PM 25651066
ER
PT J
AU Gotham, K
Brunwasser, SM
Lord, C
AF Gotham, Katherine
Brunwasser, Steven M.
Lord, Catherine
TI Depressive and Anxiety Symptom Trajectories From School Age Through
Young Adulthood in Samples With Autism Spectrum Disorder and
Developmental Delay
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
LA English
DT Article
DE autism spectrum disorder; depression; anxiety; growth curve; Child
Behavior Checklist
ID MENTAL-RETARDATION; INTELLECTUAL DISABILITY; PSYCHIATRIC COMORBIDITY;
MALADAPTIVE BEHAVIORS; ASPERGER SYNDROME; ADOLESCENTS; CHILDREN;
PSYCHOPATHOLOGY; PEOPLE; YOUTH
AB Objective: The objectives of this study were to model growth in anxiety and depressive symptoms from late school age through young adulthood in individuals with autism spectrum disorder (ASD) and controls with developmental delay (DD), and to assess relationships among internalizing growth patterns, participant characteristics, baseline predictors, and distal outcomes.
Method: Data were collected between ages 6 and 24 years in 165 participants (n = 109 with ASD; n = 56 with non-spectrum DD), most of whom received diagnostic evaluations in both childhood and early adulthood. Questionnaires were collected approximately every 3 to 6 months between ages 9 and 24 years. Parent-rated Child Behavior Checklist (CBCL), Adult Behavior Checklist (ABCL), and Developmental Behaviour Checklist anxiety-and depression-related subscale distributions were modeled with mixed-effects Poisson models, covarying diagnosis, age, verbal IQ (VIQ), gender, and significant 2- and 3-way interactions.
Results: Anxiety was positively associated with VIQ, and controlling for VIQ, both anxiety and depressive symptoms were greater in ASD than non-spectrum participants. Female gender predicted greater increases over time in anxiety and depressive symptoms for both diagnostic groups. Lower maternal education was associated with increasing internalizing symptoms in a subset of less verbal individuals with ASD. In exploratory post hoc analyses, internalizing symptoms were associated with poorer emotional regulation in school age, and with lower life satisfaction and greater social difficulties in early adulthood.
Conclusion: Findings support previous claims that individuals with ASD are at particular risk for affect- and anxiety-specific problems. Although symptom levels in females increase at a faster rate throughout adolescence, males with ASD appear to have elevated levels of depressive symptoms in school age that are maintained into young adulthood.
C1 [Gotham, Katherine] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
[Brunwasser, Steven M.] Vanderbilt Univ, Kennedy Ctr, Nashville, TN 37235 USA.
[Lord, Catherine] Weill Cornell Med Coll, Ctr Autism & Dev Brain, New York, NY USA.
RP Gotham, K (reprint author), Vanderbilt Bill Wilkerson Ctr, 1215 21st Ave South,MCE South Tower 8310, Nashville, TN 37203 USA.
EM katherine.gotham@vanderbilt.edu
FU National Institute of Mental Health [T32-MH18921, R01-MH57167,
R01-MH066469, R01-MH081873-01A1, K01-MH103500-01A1]
FX This work was supported by funding from the National Institute of Mental
Health (T32-MH18921; R01-MH57167, R01-MH066469; R01-MH081873-01A1;
K01-MH103500-01A1)
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NR 45
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0890-8567
EI 1527-5418
J9 J AM ACAD CHILD PSY
JI J. Am. Acad. Child Adolesc. Psychiatr.
PD MAY
PY 2015
VL 54
IS 5
BP 369
EP 376
DI 10.1016/j.jaac.2015.02.005
PG 8
WC Psychology, Developmental; Pediatrics; Psychiatry
SC Psychology; Pediatrics; Psychiatry
GA CG9WE
UT WOS:000353670000007
PM 25901773
ER
PT J
AU Valluy, J
Bicker, S
Aksoy-Aksel, A
Lackinger, M
Sumer, S
Fiore, R
Wust, T
Seffer, D
Metge, F
Dieterich, C
Wohr, M
Schwarting, R
Schratt, G
AF Valluy, Jeremy
Bicker, Silvia
Aksoy-Aksel, Ayla
Lackinger, Martin
Sumer, Simon
Fiore, Roberto
Wuest, Tatjana
Seffer, Dominik
Metge, Franziska
Dieterich, Christoph
Woehr, Markus
Schwarting, Rainer
Schratt, Gerhard
TI A coding-independent function of an alternative Ube3a transcript during
neuronal development
SO NATURE NEUROSCIENCE
LA English
DT Article
ID UBIQUITIN-PROTEIN LIGASE; ANGELMAN-SYNDROME; MESSENGER-RNAS; GENE UBE3A;
NEUROPSYCHIATRIC DISORDERS; IN-VIVO; MICRORNAS; SYNAPSE; AUTISM;
DENDRITOGENESIS
AB The E3 ubiquitin ligase Ube3a is an important regulator of activity-dependent synapse development and plasticity. Ube3a mutations cause Angelman syndrome and have been associated with autism spectrum disorders (ASD). However, the biological significance of alternative Ube3a transcripts generated in mammalian neurons remains unknown. We report here that Ube3a1 RNA, a transcript that encodes a truncated Ube3a protein lacking catalytic activity, prevents exuberant dendrite growth and promotes spine maturation in rat hippocampal neurons. Surprisingly, Ube3a1 RNA function was independent of its coding sequence but instead required a unique 3' untranslated region and an intact microRNA pathway. Ube3a1 RNA knockdown increased activity of the plasticity-regulating miR-134, suggesting that Ube3a1 RNA acts as a dendritic competing endogenous RNA. Accordingly, the dendrite-growth-promoting effect of Ube3a1 RNA knockdown in vivo is abolished in mice lacking miR-134. Taken together, our results define a noncoding function of an alternative Ube3a transcript in dendritic protein synthesis, with potential implications for Angelman syndrome and ASD.
C1 [Valluy, Jeremy; Bicker, Silvia; Aksoy-Aksel, Ayla; Lackinger, Martin; Sumer, Simon; Fiore, Roberto; Schratt, Gerhard] Univ Marburg, Inst Physiol Chem, Biochem Pharmacol Ctr Marburg, D-35032 Marburg, Germany.
[Wuest, Tatjana] Heidelberg Univ, Interdisciplinary Ctr Neurosci, SFB Jr Grp 488, Heidelberg, Germany.
[Seffer, Dominik; Woehr, Markus; Schwarting, Rainer] Univ Marburg, Behav Neurosci Expt & Biol Psychol, D-35032 Marburg, Germany.
[Metge, Franziska; Dieterich, Christoph] Max Planck Inst Biol Ageing, Computat RNA Biol Lab, Cologne, Germany.
RP Schratt, G (reprint author), Univ Marburg, Inst Physiol Chem, Biochem Pharmacol Ctr Marburg, D-35032 Marburg, Germany.
EM schratt@staff.uni-marburg.de
FU European Research Council; European Union FP7 ("EpimiRNA"); Deutsche
Forschungsgemeinschaft (DFG) [SFB593, FOR2107:SCHR 1136/3-1];
Universitatsklinikum Giessen-Marburg; DFG [FOR2107, SCHW 559/14-1, WO
1732/4-1]; Von Behring-Rontgen-Foundation [62-0004]
FX We acknowledge technical assistance of U. Beck, E. Becker, R. Gondrum,
G. Jarosch, H. Kaiser and H. Rippberger. This work was funded by grants
from the European Research Council (Starting Grant "Neuromir"), the
European Union FP7 ("EpimiRNA"), the Deutsche Forschungsgemeinschaft
(DFG) (SFB593, FOR2107:SCHR 1136/3-1) and the Universitatsklinikum
Giessen-Marburg to G.S., the DFG (FOR2107) to R.S. (SCHW 559/14-1) and
M.W. (WO 1732/4-1) and the Von Behring-Rontgen-Foundation (62-0004) to
S.B.
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NR 49
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1097-6256
EI 1546-1726
J9 NAT NEUROSCI
JI Nat. Neurosci.
PD MAY
PY 2015
VL 18
IS 5
BP 666
EP +
DI 10.1038/nn.3996
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA CG9LN
UT WOS:000353636900013
PM 25867122
ER
PT J
AU Holmes, GL
Tian, CJ
Hernan, AE
Flynn, S
Camp, D
Barry, J
AF Holmes, Gregory L.
Tian, Chengju
Hernan, Amanda E.
Flynn, Sean
Camp, Devon
Barry, Jeremy
TI Alterations in sociability and functional brain connectivity caused by
early-life seizures are prevented by bumetanide
SO NEUROBIOLOGY OF DISEASE
LA English
DT Article
DE Epilepsy; Sociability; Power spectrum; Development; Coherence; Voltage
correlations
ID AUTISM SPECTRUM DISORDERS; LONG-TERM POTENTIATION;
HIPPOCAMPAL-PREFRONTAL NETWORK; NEONATAL SEIZURES; TUBEROUS SCLEROSIS;
RECURRENT SEIZURES; THETA-OSCILLATIONS; INBRED STRAINS; EEG COHERENCE;
1ST YEAR
AB There is a well-described association between infantile epilepsy and pervasive cognitive and behavioral deficits, including a high incidence of autism spectrum disorders. Despite the robustness of the relationship between early-life seizures and the development of autism, the pathophysiological mechanism by which this occurs has not been explored. As a result of increasing evidence that autism is a disorder of brain connectivity we hypothesized that early-life seizures would interrupt normal brain connectivity during brain maturation and result in an autistic phenotype. Normal rat pups underwent recurrent flurothyl-induced seizures from postnatal (P) days 5-14 and then tested, along with controls, for developmental alterations of development brain oscillatory activity from P18-P25. Specifically we wished to understand how normal changes in rhythmicity in and between brain regions change as a function of age and if this rhythmicity is altered or interrupted by early life seizures.
In rat pups with early-life seizures, field recordings from dorsal and ventral hippocampus and prefrontal cortex demonstrated marked increase in coherence as well as a decrease in voltage correlation at all bandwidths compared to controls while there were minimal differences in total power and relative power spectral densities. Rats with early-life seizures had resulting impairment in the sociability and social novelty tests but demonstrated no evidence of increased activity or generalized anxiety as measured in the open field. In addition, rats with early-life seizures had lower seizure thresholds than controls, indicating long-standing alterations in the excitatory/inhibition balance. Bumetanide, a pharmacological agent that blocks the activity of NKCC1 and induces a significant shift of Ea toward more hyperpolarized values, administration at the time of the seizures precluded the subsequent abnormalities in coherence and voltage correlation and resulted in normal sociability and seizure threshold. Taken together these findings indicate that early-life seizures alter the development of oscillations and result in autistic-like behaviors. The altered communication between these brain regions could reflect the physiological underpinnings underlying social cognitive deficits seen in autism spectrum disorders. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Holmes, Gregory L.; Tian, Chengju; Hernan, Amanda E.; Flynn, Sean; Camp, Devon; Barry, Jeremy] Univ Vermont, Coll Med, Dept Neurol Sci, Burlington, VT 05405 USA.
RP Holmes, GL (reprint author), 95 Carrigan Dr,Stafford 118, Burlington, VT 05405 USA.
EM Gregory.holmes@uvm.edu
FU National Institute of Health [NS074450, NS073083]; Emmory R. Shapses
Research Fund; Michael J. Pietroniro Research Fund; NIH from the COBRE
Program of the National Center for Research Resources [P30 RR032135];
National Institute of General Medical Sciences [P30 GM 103498]
FX This study has beensupported by the National Institute of Health grants
NS074450, NS074450 and NS073083, the Emmory R. Shapses Research Fund and
Michael J. Pietroniro Research Fund to GLH and NIH grant number P30
RR032135 from the COBRE Program of the National Center for Research
Resources and P30 GM 103498 from the National Institute of General
Medical Sciences.
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NR 84
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0969-9961
EI 1095-953X
J9 NEUROBIOL DIS
JI Neurobiol. Dis.
PD MAY
PY 2015
VL 77
BP 204
EP 219
DI 10.1016/j.nbd.2015.02.015
PG 16
WC Neurosciences
SC Neurosciences & Neurology
GA CG9CO
UT WOS:000353612200018
PM 25766676
ER
PT J
AU Lawson, RA
Papadakis, AA
Higginson, CI
Barnett, JE
Wills, MC
Strang, JF
Wallace, GL
Kenworthy, L
AF Lawson, Rachel A.
Papadakis, Alison A.
Higginson, Christopher I.
Barnett, Jeffrey E.
Wills, Meagan C.
Strang, John F.
Wallace, Gregory L.
Kenworthy, Lauren
TI Everyday Executive Function Impairments Predict Comorbid Psychopathology
in Autism Spectrum and Attention Deficit Hyperactivity Disorders
SO NEUROPSYCHOLOGY
LA English
DT Article
DE autism; ADHD; executive function; aggression; anxiety/depression
ID OBSESSIVE-COMPULSIVE DISORDER; DEFICIT/HYPERACTIVITY DISORDER;
PERSEVERATIVE COGNITION; DEVELOPMENTAL DISORDERS; PSYCHIATRIC-DISORDERS;
ACADEMIC-ACHIEVEMENT; UNIPOLAR DEPRESSION; ASPERGER-SYNDROME;
WORKING-MEMORY; CHILDREN
AB Objective: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) both have psychiatric comorbidities and distinctive profiles of executive dysfunction. Although there is evidence that executive function (EF) plays a role in the expression of specific behaviors and psychiatric symptoms, it is not known whether specific EF deficits in ASD and ADHD may be pathways to comorbidities in the disorders. This study examines whether parent reported problems with flexibility in ASD and inhibition in ADHD mediate the disorders' associations with anxiety/depression and oppositional/ aggressive behavior, respectively. Method: Parent report data from the Behavior Rating Inventory of Executive Function (BRIEF) and the Child Behavior Checklist (CBCL) were obtained for 125 children (70 ASD, 55 ADHD Hyperactive/Impulsive or Combined type) as part of a neuropsychological assessment. Diagnostic status, BRIEF Shift (shifting/flexibility) and Inhibit (behavioral inhibition) scale scores, and CBCL Anxious/Depressed (anxiety/depression) and Aggressive Behavior (oppositionality/aggression) scale scores were analyzed with a path analysis to investigate the relation of flexibility and inhibition to comorbid symptoms in children with ASD and ADHD. Results: In a path model with good fit ASD predicted greater inflexibility which predicted greater anxiety/depression, while ADHD predicted greater disinhibition that predicted greater aggression, consistent with our mediational hypotheses. Unexpectedly, the greater inflexibility associated with ASD also predicted greater aggression. Conclusions: Findings support the importance of everyday EF problems in ASD and ADHD as predictors of comorbid psychopathology and as crucial intervention targets for potential prevention and mitigation of comorbid symptoms.
C1 [Lawson, Rachel A.; Papadakis, Alison A.; Higginson, Christopher I.; Barnett, Jeffrey E.] Loyola Univ Maryland, Dept Psychol, Baltimore, MD 21210 USA.
[Wills, Meagan C.; Strang, John F.; Kenworthy, Lauren] Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, Rockville, MD USA.
[Wallace, Gregory L.] George Washington Univ, Dept Speech & Hearing Sci, Washington, DC 20052 USA.
RP Lawson, RA (reprint author), Loyola Univ Maryland, Dept Psychol, 4501 N Charles St, Baltimore, MD 21210 USA.
EM rachel.lawson112@gmail.com
FU Isadore and Bertha Gudelsky Foundation; Frederick and Elizabeth Singer
Foundation
FX LK receives financial compensation for use of the Behavior Rating
Inventory of Executive Function (BRIEF). This research was supported by
the Isadore and Bertha Gudelsky Foundation, and the Frederick and
Elizabeth Singer Foundation. We thank the families of the participants
and the diagnostic team that characterized the participants for their
efforts over the years.
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NR 77
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
EI 1931-1559
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD MAY
PY 2015
VL 29
IS 3
BP 445
EP 453
DI 10.1037/neu0000145
PG 9
WC Psychology, Clinical; Neurosciences; Psychology
SC Psychology; Neurosciences & Neurology
GA CH3CX
UT WOS:000353905300013
PM 25313979
ER
PT J
AU Erviti, M
Semal, C
Wright, BA
Amestoy, A
Bouvard, MP
Demany, L
AF Erviti, Mayalen
Semal, Catherine
Wright, Beverly A.
Amestoy, Anouck
Bouvard, Manuel P.
Demany, Laurent
TI A Late-Emerging Auditory Deficit in Autism
SO NEUROPSYCHOLOGY
LA English
DT Article
DE autism spectrum disorder; echoic memory; auditory development;
periodicity detection
ID SHORT-TERM-MEMORY; SPECTRUM DISORDERS; DEVELOPMENTAL TRAJECTORIES; PITCH
DISCRIMINATION; TEMPORAL RESOLUTION; SIGNAL-DETECTION; ECHOIC MEMORY;
TONE PITCH; CHILDREN; NOISE
AB Objective: Individuals with autism spectrum disorders (ASD) show enhanced perceptual and memory abilities in the domain of pitch, but also perceptual deficits in other auditory domains. The present study investigated their skills with respect to "echoic memory," a form of short-term sensory memory intimately tied to auditory perception, using a developmental perspective. Method: We tested 23 high-functioning participants with ASD and 26 typically developing (TD) participants, distributed in two age groups (children vs. young adults; mean ages: similar to 11 and similar to 21 years). By means of an adaptive psychophysical procedure, we measured the longest period for which periodic (i.e., repeated) noise could be reliably discriminated from nonperiodic (i.e., plain random) noise. On each experimental trial, a single noise sample was presented to the participant, who had to classify this sound as periodic or nonperiodic. Results: The TD adults performed, on average, much better than the other three groups, who performed similarly overall. As a function of practice, the measured thresholds improved for the TD participants, but did not change for the ASD participants. Thresholds were not correlated to performance in a test assessing verbal memory. The variance of the participants' response biases was larger among the ASD participants than among the TD participants. Conclusion: The results mainly suggest that echoic memory takes a long time to fully develop in TD humans, and that this development stops prematurely in persons with ASD.
C1 [Erviti, Mayalen; Semal, Catherine; Amestoy, Anouck; Bouvard, Manuel P.; Demany, Laurent] CNRS, F-75700 Paris, France.
[Erviti, Mayalen] Univ Bordeaux, Talence, France.
[Semal, Catherine] Inst Polytech Bordeaux, Bordeaux, France.
[Wright, Beverly A.] Northwestern Univ, Dept Commun Sci & Disorders, Evanston, IL 60208 USA.
[Amestoy, Anouck; Bouvard, Manuel P.; Demany, Laurent] Univ Bordeaux, UMR CNRS 5287, Inst Neurosci Cognit & Integrat Aquitaine, Talence, France.
RP Demany, L (reprint author), Univ Bordeaux 2, BP 63,146 Rue Leo Saignat, F-33076 Bordeaux, France.
EM laurent.demany@u-bordeaux.fr
FU Fondation de France [UB 032143]
FX This study was supported by the Fondation de France (UB 032143) and is
part of the doctoral thesis of author Mayalen Erviti.
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NR 63
TC 0
Z9 0
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
EI 1931-1559
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD MAY
PY 2015
VL 29
IS 3
BP 454
EP 462
DI 10.1037/neu0000162
PG 9
WC Psychology, Clinical; Neurosciences; Psychology
SC Psychology; Neurosciences & Neurology
GA CH3CX
UT WOS:000353905300014
PM 25495831
ER
PT J
AU Zurcher, NR
Bhanot, A
McDougle, CJ
Hooker, JM
AF Zuercher, Nicole R.
Bhanot, Anisha
McDougle, Christopher J.
Hooker, Jacob M.
TI A systematic review of molecular imaging (PET and SPECT) in autism
spectrum disorder: Current state and future research opportunities
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Positron emission tomography (PET); Single-photon emission computed
tomography (SPECT); Neuroimaging; Molecular imaging; Autism spectrum
disorder
ID POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL-BLOOD-FLOW; PERVASIVE
DEVELOPMENTAL DISORDERS; SEROTONIN TRANSPORTER BINDING; CHILDHOOD
AUTISM; GLUCOSE-METABOLISM; ASPERGER-SYNDROME; INFANTILE-AUTISM; BRAIN
SPECT; MICROGLIAL ACTIVATION
AB Non-invasive positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are techniques used to quantify molecular interactions, biological processes and protein concentration and distribution. In the central nervous system, these molecular imaging techniques can provide critical insights into neurotransmitter receptors and their occupancy by neurotransmitters or drugs. In recent years, there has been an increase in the number of studies that have investigated neurotransmitters in autism spectrum disorder (ASD), while earlier studies mostly focused on cerebral blood flow and glucose metabolism. The underlying and contributing mechanisms of ASD are largely undetermined and ASD diagnosis relies on the behavioral phenotype. Discovery of biochemical endophenotypes would represent a milestone in autism research that could potentially lead to ASD subtype stratification and the development of novel therapeutic drugs. This review characterizes the prior use of molecular imaging by PET and SPECT in ASD, addresses methodological challenges and highlights areas of future opportunity for contributions from molecular imaging to understand ASD pathophysiology. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Zuercher, Nicole R.; Bhanot, Anisha; Hooker, Jacob M.] Massachusetts Gen Hosp, Dept Radiol, AA Martinos Ctr Biomed Imaging, Charlestown, MA USA.
[Zuercher, Nicole R.; Hooker, Jacob M.] Harvard Univ, Sch Med, Boston, MA USA.
[McDougle, Christopher J.] MassGen Hosp Children, Dept Pediat, Lurie Ctr Autism, Lexington, MA USA.
[McDougle, Christopher J.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
RP Hooker, JM (reprint author), Athinoula A Martinos Ctr Biomed Imaging, Bldg 149,13th St,Suite 2301, Charlestown, MA 02129 USA.
EM hooker@martinos.org
FU Robert E. and Donna Landreth Fund for the Study of Neuroinflammation in
Autism; Autism Speaks Meixner Translational Postdoctoral Fellowship
[9258]
FX The authors acknowledge support from the Robert E. and Donna Landreth
Fund for the Study of Neuroinflammation in Autism. Nicole R. Zurcher was
funded by an Autism Speaks Meixner Translational Postdoctoral Fellowship
(#9258). The authors would like to thank Nouchine Hadjikhani for helpful
comments on an earlier version of the manuscript and Regan Butterfield
for discussions regarding Fig. 1.
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NR 131
TC 1
Z9 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAY
PY 2015
VL 52
BP 56
EP 73
DI 10.1016/j.neubiorev.2015.02.002
PG 18
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CG8YJ
UT WOS:000353601300005
PM 25684726
ER
PT J
AU Naaijen, J
Lythgoe, DJ
Amiri, H
Buitelaar, JK
Glennon, JC
AF Naaijen, Jilly
Lythgoe, David J.
Amiri, Houshang
Buitelaar, Jan K.
Glennon, Jeffrey C.
TI Fronto-striatal glutamatergic compounds in compulsive and impulsive
syndromes: A review of magnetic resonance spectroscopy studies
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Magnetic resonance spectroscopy; Compulsivity; Impulsivity; ADHD;
Autism; OCD; Glutamate; GABA
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS;
DEFICIT HYPERACTIVITY DISORDER; COGNITIVE-BEHAVIORAL THERAPY; SYMPTOM
SEVERITY; METABOLITE ALTERATIONS; PROTON SPECTROSCOPY; PREFRONTAL
CORTEX; MAJOR DEPRESSION; HEALTHY CONTROLS
AB Compulsivity and impulsivity are cross-disorder traits observed in autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). Aberrant fronto-striatal glutamatergic signalling is core to the understanding of compulsive and impulsive disorders. In this review, the glutamate (Glu) neurochemistry of fronto-striatal circuits in paediatric and adult ASD, ADHD and OCD, as described in 59 studies, is outlined from the perspective of proton magnetic resonance spectroscopy (H-1 MRS). Despite the methodological inconsistencies between studies, two observations stand out that form possible hypotheses for future studies. Firstly, a possible increase in Glx (combination of Glu, glutamine and GABA) in the striatum across ADHD, OCD and ASD. Secondly, an increased Glx signal in the anterior cingulate cortex in paediatric ASD and ADHD but a lower Glx signal in adult ASD and ADHD. This suggests neurodevelopmental changes in fronto-striatal glutamatergic circuits across the lifespan. Future studies should incorporate more homogeneous samples, perform MRS at field strengths of at least 3 Tesla and provide much more precise and standardized information on methods to improve our understanding of fronto-striatal glutamatergic transmission in compulsive and impulsive syndromes. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Naaijen, Jilly; Amiri, Houshang; Buitelaar, Jan K.; Glennon, Jeffrey C.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, NL-6525 EZ Nijmegen, Netherlands.
[Lythgoe, David J.] Kings Coll London, Dept Neuroimaging, Inst Psychiat, London SE5 8AF, England.
[Amiri, Houshang] Radboud Univ Nijmegen, Med Ctr, Dept Radiol, NL-6500 HB Nijmegen, Netherlands.
[Amiri, Houshang] Kerman Univ Med Sci, Inst Neuropharmacol, Neurosci Res Ctr, Kerman, Iran.
[Buitelaar, Jan K.] Karakter Child & Adolescent Psychiat Univ Ctr, NL-6525 GC Nijmegen, Netherlands.
RP Naaijen, J (reprint author), Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Geert Grootepl Noord 10,Huispost 126, NL-6525 EZ Nijmegen, Netherlands.
EM j.naaijen@donders.ru.nl; david.lythgoe@kcl.ac.uk;
amiri.houshang@gmail.com; jan.buitelaar@radboudumc.nl;
jeffrey.glennon@radboudumc.nl
RI ahmed, Jamila/E-8653-2015
FU European Community [278948]
FX The research leading to these results has received funding from the
European Community's Seventh Framework Programme (FP7/2007-2013) TACTICS
under grant agreement no. 278948.
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PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAY
PY 2015
VL 52
BP 74
EP 88
DI 10.1016/j.neubiorev.2015.02.009
PG 15
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CG8YJ
UT WOS:000353601300006
PM 25712432
ER
PT J
AU Zantomio, D
Chana, G
Laskaris, L
Testa, R
Everall, I
Pantelis, C
Skafidas, E
AF Zantomio, Daniela
Chana, Gursharan
Laskaris, Liliana
Testa, Renee
Everall, Ian
Pantelis, Christos
Skafidas, Efstratios
TI Convergent evidence for mGluR5 in synaptic and neuroinflammatory
pathways implicated in ASD
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Article
DE mGluR5; Glutamate; Autism spectrum disorder; Neurodevelopment; GRM5;
Neuroinflammation; Microglia
ID METABOTROPIC GLUTAMATE-RECEPTOR; AUTISM SPECTRUM DISORDERS;
FRAGILE-X-SYNDROME; TUBEROUS SCLEROSIS COMPLEX; LONG-TERM POTENTIATION;
RETT-SYNDROME; MOUSE MODEL; MICROGLIAL ACTIVATION; PROTEIN-SYNTHESIS;
CENTRAL MECHANISM
AB The pathogenesis of Autism Spectrum Disorder (ASD), a serious neurodevelopmental disorder, is poorly understood. We review evidence for alterations in glutamatergic signalling in the aetiology of ASD, with a focus on the metabotropic glutamate receptor-5 (mGluR5). mGluR5 signalling is important for synapse formation, neuroplasticity and long term potentiation as well as neuroprotection and has been shown to have a regulatory role in neuroinflammation. Evidence for neuroinflammation in ASD is supported by increase in pro-inflammatory cytokines in the blood and cerebrospinal fluid (CSF) and increased number and activation of microglia in postmortem dorsolateral prefrontal cortex (DLPFC). mGlur5 signalling has also been shown to downregulate microglial activation. Therefore, we focus on mGluR5 as a potential unifying explanation for synapse alteration and neuroinflammation seen in ASD. Data from mGluR5 knockout mouse models, and syndromic and non syndromic forms of ASD are discussed in relation to how alterations in mGluR5 are associated with ASD symptoms. This review supports altered mGluR5 functioning as a convergent point in ASD pathogenesis and indicates more research is warranted into mGluR5 as a potential therapeutic target. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Zantomio, Daniela] Austin Hlth, Dept Haematol, Heidelberg, Vic, Australia.
[Zantomio, Daniela; Chana, Gursharan; Laskaris, Liliana; Skafidas, Efstratios] Univ Melbourne, Ctr Neural Engn, Parkville, Vic 3052, Australia.
[Chana, Gursharan; Laskaris, Liliana; Everall, Ian; Pantelis, Christos; Skafidas, Efstratios] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia.
[Testa, Renee; Pantelis, Christos] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Parkville, Vic 3052, Australia.
[Testa, Renee; Pantelis, Christos] Melbourne Hlth, Parkville, Vic, Australia.
[Testa, Renee] Monash Univ, Dept Psychol, Clayton, Vic 3168, Australia.
[Chana, Gursharan; Everall, Ian; Pantelis, Christos; Skafidas, Efstratios] Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia.
[Skafidas, Efstratios] Ctr Integrat Brain Funct, Melbourne, Vic, Australia.
RP Skafidas, E (reprint author), Univ Melbourne, Ctr Neural Engn, Carlton, Vic 3053, Australia.
EM sskaf@unimelb.edu.au
FU NHMRC [628386]; NASRAD Distinguish Investigator Award (Brain & Behavior
Research Foundation, US) [18722]
FX Prof Christos Pantelis was supported by a NHMRC Senior Principal
Research Fellowship (ID: 628386) and NASRAD Distinguish Investigator
Award (Brain & Behavior Research Foundation, US, Grant ID: 18722).
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NR 70
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAY
PY 2015
VL 52
BP 172
EP 177
DI 10.1016/j.neubiorev.2015.02.006
PG 6
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CG8YJ
UT WOS:000353601300012
PM 25704074
ER
PT J
AU Van der Hallen, R
Evers, K
Brewaeys, K
Van den Noortgate, W
Wagemans, J
AF Van der Hallen, Ruth
Evers, Kris
Brewaeys, Katrien
Van den Noortgate, Wim
Wagemans, Johan
TI Global Processing Takes Time: A Meta-Analysis on Local-Global Visual
Processing in ASD
SO PSYCHOLOGICAL BULLETIN
LA English
DT Article
DE autism spectrum disorder; developmental disorders; meta-analysis;
perception; vision science
ID HIGH-FUNCTIONING AUTISM; EMBEDDED FIGURES TASK; SUPERIOR DISEMBEDDING
PERFORMANCE; WEAK CENTRAL COHERENCE; SPECTRUM DISORDERS;
ASPERGER-SYNDROME; ORIENTED PERCEPTION; GESTALT PSYCHOLOGY; VISUOSPATIAL
TASKS; PUBLICATION BIAS
AB What does an individual with autism spectrum disorder (ASD) perceive first: the forest or the trees? In spite of 30 years of research and influential theories like the weak central coherence (WCC) theory and the enhanced perceptual functioning (EPF) account, the interplay of local and global visual processing in ASD remains only partly understood. Research findings vary in indicating a local processing bias or a global processing deficit, and often contradict each other. We have applied a formal meta-analytic approach and combined 56 articles that tested about 1,000 ASD participants and used a wide range of stimuli and tasks to investigate local and global visual processing in ASD. Overall, results show no enhanced local visual processing nor a deficit in global visual processing. Detailed analysis reveals a difference in the temporal pattern of the local-global balance, that is, slow global processing in individuals with ASD. Whereas task-dependent interaction effects are obtained, gender, age, and IQ of either participant groups seem to have no direct influence on performance. Based on the overview of the literature, suggestions are made for future research.
C1 [Van der Hallen, Ruth; Brewaeys, Katrien; Wagemans, Johan] Katholieke Univ Leuven, Expt Psychol Lab, B-3000 Leuven, Belgium.
[Van der Hallen, Ruth; Wagemans, Johan] Katholieke Univ Leuven, Leuven Autism Res LAuRes, B-3000 Leuven, Belgium.
[Evers, Kris] UPC KU Leuven, Expt Psychol Lab, Leuven Autism Res LAuRes, Louvain, Belgium.
[Evers, Kris] UPC KU Leuven, Child & Adolescent Psychiat, Louvain, Belgium.
[Van den Noortgate, Wim] Katholieke Univ Leuven, Methodol Educ Sci, B-3000 Leuven, Belgium.
RP Van der Hallen, R (reprint author), Katholieke Univ Leuven, Expt Psychol Lab, B-3000 Leuven, Belgium.
EM ruth.vanderhallen@ppw.kuleuven.be
FU Methusalem grant by the Flemish Government [METH/08/02]
FX The authors would like to thank everybody who has devoted time to
reading and commenting this article, in particular the three anonymous
reviewers. This research was funded by a Methusalem grant awarded to
Johan Wagemans by the Flemish Government (METH/08/02).
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NR 96
TC 1
Z9 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0033-2909
EI 1939-1455
J9 PSYCHOL BULL
JI Psychol. Bull.
PD MAY
PY 2015
VL 141
IS 3
BP 549
EP 573
DI 10.1037/bul0000004
PG 25
WC Psychology; Psychology, Multidisciplinary
SC Psychology
GA CH0PR
UT WOS:000353725000003
PM 25420221
ER
PT J
AU Blackford, JU
Williams, LE
Heckers, S
AF Blackford, J. U.
Williams, L. E.
Heckers, S.
TI Neural correlates of out-group bias predict social impairment in
patients with schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; fMRI; Habituation; Social functioning
ID AUTISM SPECTRUM DISORDERS; BIPOLAR DISORDER; HUMAN AMYGDALA;
HABITUATION; RECOGNITION; SELF; HIPPOCAMPUS; PERCEPTION; STIMULI; FACES
AB Background: Social impairments are a hallmark feature of schizophrenia and are a key predictor of functional disability. Deficits in social information processing likely underlie social impairment; however, this relationship is understudied. We previously demonstrated that patients with schizophrenia fail to habituate to neutral faces, providing evidence for an alteration in basic social information processing. It remains unknown whether patients with schizophrenia also show deficits in processing of more complex social information. Outgroup bias provides an excellent opportunity to test complex social information processing because the bias requires basic face processing skills, the ability to discriminate between groups, as well as the ability to categorize oneself into a salient social group.
Methods: Study participants were 23 patients with schizophrenia and 21 controls. Using functional magnetic resonance imaging, habituation of response to 120 s of repeated presentations of faces was assessed in participants who viewed either same-gender faces or opposite-gender faces. The interaction between face gender (same/opposite) and group was examined in three key regions: amygdala, hippocampus, and visual cortex. Social impairment was measured using the PANSS and correlations between social impairment and out-group effect (main effect of face type) were performed in patients.
Results: Patients with schizophrenia had aberrant neural responses to opposite-gender faces (interaction, p < .05 corrected). Healthy controls showed an immediate heightened response to opposite-gender faces relative to same-gender faces; but in patients this effect was substantially delayed (similar to 70 s). In patients with schizophrenia, the out-group bias was significantly correlated with social impairment. Patients with no social impairment showed a heightened neural response to opposite-gender faces after 30 s, whereas patients with mild-moderate social impairment failed to ever show a heightened response.
Conclusion: Alterations in neural responses during out-group processing predicted degree of social impairment in patients with schizophrenia; thus, neural responses to opposite-gender faces may provide a novel measure for studies of treatment response and disease outcome. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Blackford, J. U.; Heckers, S.] Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37212 USA.
[Williams, L. E.] Univ ofWisconsin, Wisconsin Psychiat Inst & Clin, Dept Psychiat, Madison, WI 53719 USA.
RP Blackford, JU (reprint author), 1601 23rd Ave South,Suite 3057J, Nashville, TN 37212 USA.
EM j.blackford@vanderbilt.edu
FU National Institute of Mental Health [R01 MH070560, K01 MH083052];
National Center for Research Resources [UL1 RR024975-01, 2 UL1
TR000445-06]
FX This work was supported by the National Institute of Mental Health (R01
MH070560 to SH; K01 MH083052 to JUB), and the National Center for
Research Resources (grant UL1 RR024975-01, now at the National Center
for Advancing Translational Sciences, grant 2 UL1 TR000445-06, to LEW).
The NIMH had no further role in study design; in the collection,
analysis, and interpretation of data; in the writing of the report; or
in the decision to submit the paper for publication. The content is
solely the responsibility of the authors and does not necessarily
represent the official views of the NIH.
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NR 36
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAY
PY 2015
VL 164
IS 1-3
BP 203
EP 209
DI 10.1016/j.schres.2015.03.019
PG 7
WC Psychiatry
SC Psychiatry
GA CG5MX
UT WOS:000353337100030
PM 25864952
ER
PT J
AU Rahkonen, P
Lano, A
Pesonen, AK
Heinonen, K
Raikkonen, K
Vanhatalo, S
Autti, T
Valanne, L
Andersson, S
Metsaranta, M
AF Rahkonen, Petri
Lano, Aulikki
Pesonen, Anu-Katriina
Heinonen, Kati
Raikkonen, Katri
Vanhatalo, Sampsa
Autti, Taina
Valanne, Leena
Andersson, Sture
Metsaranta, Marjo
TI Atypical sensory processing is common in extremely low gestational age
children
SO ACTA PAEDIATRICA
LA English
DT Article
DE Autism spectrum disorder; Neonate; Patent ductus arteriosus ligation;
Preterm; Sensory processing
ID PATENT DUCTUS-ARTERIOSUS; BIRTH-WEIGHT INFANTS; PRETERM INFANTS;
NEURODEVELOPMENTAL OUTCOMES; SURGICAL CLOSURE; PARALYSIS; EVOLUTION;
PROFILES; AUTISM
AB AimAtypical sensory processing is common in children born extremely prematurely. We investigated sensory processing abilities in extremely low gestational age (ELGA) children and analysed associated neonatal risk factors, neuroanatomical findings and neurodevelopmental outcome.
MethodsWe carried out a prospective study of 44 ELGA children, including 42 who had undergone brain magnetic resonance imaging (MRI) at term-equivalent age, when they were 2years of corrected age. Their sensory processing abilities were assessed with the Infant/Toddler Sensory Profile questionnaire and their neurodevelopmental with a structured Hempel neurological examination, Griffiths Mental Developmental Scales and Bayley Scales of Infant and Toddler Development Third Edition.
ResultsSensory profiles were definitely or probably atypical (<-1 SD) in half of the ELGA children, and the most common behavioural pattern was low registration (23%). Sensation seeking was associated with abnormalities in grey and/or white matter in the brain MRI (p<0.01). Atypical oral sensory processing was associated with surgical closure of the patent ductus arteriosus (p=0.02, adjusted p<0.01).
ConclusionAtypical sensory processing in ELGA children was common, and children with neonatal neuroanatomical lesions tended to present specific behavioural responses to sensory stimuli. Surgical closure of the patent ductus arteriosus may predispose infants to feeding problems due to atypical oral sensory processing.
C1 [Rahkonen, Petri; Andersson, Sture; Metsaranta, Marjo] Univ Helsinki, Childrens Hosp, Dept Pediat, Helsinki, Finland.
[Lano, Aulikki] Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
[Pesonen, Anu-Katriina; Heinonen, Kati; Raikkonen, Katri] Univ Helsinki, Inst Behav Sci, Helsinki, Finland.
[Vanhatalo, Sampsa] Univ Helsinki, Childrens Hosp, Dept Clin Neurophysiol, Helsinki, Finland.
[Autti, Taina; Valanne, Leena] Univ Helsinki, Med Imaging Ctr, Helsinki, Finland.
RP Rahkonen, P (reprint author), Univ Helsinki, Childrens Hosp, POB 281, Helsinki 00029, Hus, Finland.
EM petri.rahkonen@hus.fi
FU Jenny and Antti Wihuri Foundation; Academy of Finland (Centre of
Excellence Program); Finnish Medical Foundation; Finska
Lakaresallskapet; Helsinki University Central Hospital; Foundation for
Pediatric Research; Paivikki and Sakari Sohlberg Foundation; Emil
Aaltonen Foundation; Signe and Ane Gyllenberg Foundation; Maud Kuistila
Memorial Foundation; Arvo and Lea Ylppo Foundation; Orion Research
Foundation
FX The study was financially supported by the Jenny and Antti Wihuri
Foundation, the Academy of Finland (Centre of Excellence Program), the
Finnish Medical Foundation, Finska Lakaresallskapet, the Helsinki
University Central Hospital Research Grants, the Foundation for
Pediatric Research, the Paivikki and Sakari Sohlberg Foundation, the
Emil Aaltonen Foundation, the Signe and Ane Gyllenberg Foundation, the
Maud Kuistila Memorial Foundation, the Arvo and Lea Ylppo Foundation and
the Orion Research Foundation.
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NR 30
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0803-5253
EI 1651-2227
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD MAY
PY 2015
VL 104
IS 5
BP 522
EP 528
DI 10.1111/apa.12911
PG 7
WC Pediatrics
SC Pediatrics
GA CG9NT
UT WOS:000353643400028
PM 25620288
ER
PT J
AU Fieder, M
Huber, S
AF Fieder, Martin
Huber, Susanne
TI Paternal Age Predicts Offspring Chances of Marriage and Reproduction
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article
ID DE-NOVO MUTATIONS; RISK; SCHIZOPHRENIA; AUTISM; COHORT
AB ObjectivesMutation-selection balance theory proposes that a balance of forces between constantly arising mildly harmful mutations and selection causes variation in genetic configuration and phenotypic condition. As mutations are predominantly deleterious, the entry of variation due to mutations is kept at low frequencies by selection. It has recently been demonstrated that nearly all de novo mutation are caused by paternal age.
MethodsWe examined on basis of the Wisconsin Longitudinal Study (n=6,182) whether a subject's probability of having ever married as well as having ever reproduced is associated with that subject's father's age at subject's birth.
ResultsWe find that advanced paternal but not maternal age at subject's birth predicts a lower chance of ever being married and a higher chance of childlessness, even controlling for various confounders.
ConclusionsAs marriage is a prerequisite of reproduction in this sample, we discuss that mate choice may provide a mechanism to prevent too high mutation load in the progeny. Am. J. Hum. Biol. 27:339-343, 2015. (c) 2014 Wiley Periodicals, Inc.
C1 [Fieder, Martin; Huber, Susanne] Univ Vienna, Dept Anthropol, A-1090 Vienna, Austria.
RP Fieder, M (reprint author), Univ Vienna, Dept Anthropol, Althanstr 14, A-1090 Vienna, Austria.
EM martin.fieder@univie.ac.at
FU University of Vienna
FX Contract grant sponsor: University of Vienna (Back to Research Grant to
SH).
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NR 24
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD MAY-JUN
PY 2015
VL 27
IS 3
BP 339
EP 343
DI 10.1002/ajhb.22644
PG 5
WC Anthropology; Biology
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA CG4ZZ
UT WOS:000353299400007
PM 25327626
ER
PT J
AU Lo, ST
Collin, PJL
Hokken-Koelega, ACS
AF Lo, S. T.
Collin, P. J. L.
Hokken-Koelega, A. C. S.
TI Psychiatric Disorders in Children with Prader-Willi Syndrome-Results of
a 2-Year Longitudinal Study
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE Prader-Willi syndrome; psychiatric disorders; psychosis; oppositional
defiant disorder; compulsions
ID MATERNAL UNIPARENTAL DISOMY; AUTISM SPECTRUM DISORDER; GROWTH-HORMONE
TREATMENT; COMPULSIVE BEHAVIOR; PEOPLE; ADULTS; ILLNESS; ADOLESCENTS;
PREVALENCE; SYMPTOMS
AB Psychiatric disorders such as psychosis are highly prevalent in adults with Prader-Willi syndrome (PWS). However, knowledge about the presence and progression of psychiatric disorders in children with PWS is very limited. Sixty-one children with PWS aged 7-17 years were tested using the Diagnostic Interview Schedule for Children (DISC) and Compulsive Behaviour Checklist (CBC), and 38/61 were retested after 2 years. Prevalence of psychiatric disorders and the association with age, gender, genetic subtype, and total IQ were assessed. In addition, occurrence and characteristics of compulsions were determined. Prior to the study, two boys were known with psychotic symptoms and treated with antipsychotics. At baseline, none scored positive for psychotic disorder. During the follow-up, only one boy with known psychotic symptoms required a dose adjustment of his antipsychotic medication. After 2 years, none of the children had a psychotic disorder according to the DISC. Oppositional defiant disorder (ODD) was the most common diagnosis and present in 20% of children with PWS, and this was not associated with age (=-0.081, P=0.546), gender (=0.013, P=0.923), genetic subtype (=-0.073, P=0.584), or total IQ (=-0.150, P=0.267). The most common compulsions were hoarding and fixed hygiene sequences. In our large group of 61 children with PWS, the majority had no psychotic disorder and no progression was found during 2-year follow-up. ODD was present in 20% of children. No changes in the prevalence of psychiatric disorders were found during the 2-year follow-up study and genetic subtype was not related to psychosis, depression, or ODD. (c) 2015 Wiley Periodicals, Inc.
C1 [Lo, S. T.; Hokken-Koelega, A. C. S.] Dutch Growth Res Fdn, Rotterdam, Netherlands.
[Lo, S. T.; Hokken-Koelega, A. C. S.] Sophia Childrens Univ Hosp, Erasmus Univ Med Ctr, Dept Pediat, Subdiv Endocrinol, NL-3016 AH Rotterdam, Netherlands.
[Collin, P. J. L.] Koraalgroep, Sittard, Netherlands.
RP Lo, ST (reprint author), Sophia Childrens Univ Hosp, Erasmus Univ Med Ctr, Dept Pediat, Subdiv Endocrinol, Westzeedijk 106, NL-3016 AH Rotterdam, Netherlands.
EM s.lo@kindengroei.nl
FU Dutch Prader-Willi Fund; Fund NutsOhra; Dutch Growth Research Foundation
FX Grant sponsor: Dutch Prader-Willi Fund; Grant sponsor: Fund NutsOhra;
Grant sponsor: Dutch Growth Research Foundation.
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NR 40
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD MAY
PY 2015
VL 167A
IS 5
BP 983
EP 991
DI 10.1002/ajmg.a.36998
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA CG3HY
UT WOS:000353171900003
PM 25712902
ER
PT J
AU Garcia-Santiago, FA
Martinez-Glez, V
Santos, F
Garcia-Minaur, S
Mansilla, E
Meneses, AG
Rosell, J
Granero, AP
Vallespin, E
Fernandez, L
Sierra, B
Oliver-Bonet, M
Palomares, M
de Torres, ML
Mori, MA
Nevado, J
Heath, KE
Delicado, A
Lapunzina, P
AF Amalia Garcia-Santiago, Fe
Martinez-Glez, Victor
Santos, Fernando
Garcia-Minaur, Sixto
Mansilla, Elena
Gonzalez Meneses, Antonio
Rosell, Jordi
Perez Granero, Angeles
Vallespin, Elena
Fernandez, Luis
Sierra, Blanca
Oliver-Bonet, Maria
Palomares, Maria
Luisa de Torres, Maria
Angeles Mori, Maria
Nevado, Julian
Heath, Karen E.
Delicado, Alicia
Lapunzina, Pablo
TI Analysis of Invdupdel(8p) Rearrangement: Clinical, Cytogenetic and
Molecular Characterization
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE invdupdel(8p); inversion; duplication; deletion; chromosome 8; genomic
rearrangement; FISH; chromosomal microarray
ID IN-SITU HYBRIDIZATION; DUP DEL(8P); INVERTED DUPLICATION; CLEFT-LIP;
INVERSION; AUTISM; 8P; MECHANISM; EPILEPSY; MUSCLE
AB Inverted duplication 8p associated with deletion of the short arms of chromosome 8 (invdupdel[8p]) is a relatively uncommon complex chromosomal rearrangement, with an estimated incidence of 1 in 10,000-30,000 live borns. The chromosomal rearrangement consists of a deletion of the telomeric region (8p23-pter) and an inverted duplication of the 8p11.2-p22 region. Clinical manifestations of this disorder include severe to moderate intellectual disability and characteristic facial features. In most cases, there are also CNS associated malformations and congenital heart defects. In this work, we present the cytogenetic and molecular characterization of seven children with invdupdel(8p) rearrangements. Subsequently, we have carried out genotype-phenotype correlations in these seven patients. The majority of our patients carry a similar deletion but different size of duplications; the latter probably explaining the phenotypic variability among them. We recommend that complete clinical evaluation and detailed chromosomal microarray studies should be undertaken, enabling appropriate genetic counseling. (c) 2015 Wiley Periodicals, Inc.
C1 [Amalia Garcia-Santiago, Fe; Mansilla, Elena; Luisa de Torres, Maria; Delicado, Alicia] Hosp Univ La Paz, Inst Genet Med & Mol INGEMM, IdiPAZ, Cytogenet Unit, Madrid 28046, Spain.
[Martinez-Glez, Victor; Vallespin, Elena; Fernandez, Luis; Palomares, Maria; Angeles Mori, Maria; Nevado, Julian] Hosp Univ La Paz, Inst Genet Med & Mol INGEMM, IdiPAZ, Funct & Struct Genom Unit, Madrid 28046, Spain.
[Santos, Fernando; Garcia-Minaur, Sixto; Lapunzina, Pablo] Hosp Univ La Paz, Inst Genet Med & Mol INGEMM, IdiPAZ, Clin Gent Unit, Madrid 28046, Spain.
[Heath, Karen E.] Hosp Univ La Paz, Inst Genet Med & Mol INGEMM, IdiPAZ, Mol Endocrinol Unit, Madrid 28046, Spain.
[Martinez-Glez, Victor; Santos, Fernando; Garcia-Minaur, Sixto; Mansilla, Elena; Rosell, Jordi; Vallespin, Elena; Fernandez, Luis; Palomares, Maria; Luisa de Torres, Maria; Angeles Mori, Maria; Nevado, Julian; Heath, Karen E.; Delicado, Alicia; Lapunzina, Pablo] ISCIII, Ctr Invest Biomed Red Enfermedades Raras, CIBERER, Madrid, Spain.
[Gonzalez Meneses, Antonio] Hosp Virgen del Rocio, Dysmorphol Unit, Seville, Spain.
[Rosell, Jordi; Perez Granero, Angeles; Sierra, Blanca] Hosp Son Espases, Genet Unit, Palma De Mallorca, Spain.
[Oliver-Bonet, Maria] Hosp Son Espases, Res Unit, Palma de Mallorca, Spain.
RP Garcia-Santiago, FA (reprint author), Hosp Univ La Paz, Inst Genet Med & Mol INGEMM, IdiPAZ, Paseo Castellana 261, Madrid 28046, Spain.
EM feamalia.garcia@salud.madrid.org
CR Baulac S, 2008, ARCH NEUROL-CHICAGO, V65, P943, DOI 10.1001/archneur.65.7.943
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NR 26
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD MAY
PY 2015
VL 167A
IS 5
BP 1018
EP 1025
DI 10.1002/ajmg.a.36879
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA CG3HY
UT WOS:000353171900008
PM 25712135
ER
PT J
AU Louw, JJ
Corveleyn, A
Jia, YJ
Hens, G
Gewillig, M
Devriendt, K
AF Louw, Jacoba J.
Corveleyn, Anniek
Jia, Yaojuan
Hens, Greet
Gewillig, Marc
Devriendt, Koenraad
TI MEIS2 Involvement in Cardiac Development, Cleft Palate, and Intellectual
Disability
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE cleft palate; cleft lip; cardiopathy; heart; intellectual disability;
next generation sequencing (NGS)
ID HINDBRAIN BOUNDARY; GENE-EXPRESSION; ZEBRAFISH; DELETION; DEFECT; 15Q14;
DELAY
AB MEIS2 has been associated with cleft palate and cardiac septal defects as well as varying degrees of intellectual disability. We present a female patient with a more severe phenotype compared to previous reported patients. She has multiple congenital malformations; cleft palate and congenital heart defect characterized by septal defects and aortic coarctation. She has severe feeding problems, facial dysmorphism, severely delayed gross motor and verbal development, and autism spectrum disorder. Facial dysmorphism consisting of bitemporal narrowing, arched and laterally extended eyebrows, mild upslanting palpebral fissures, deep-set eyes, a tented upper lip, thin upper vermilion, full lower vermilion, broad first ray of hands and feet, a gap between the first and second toes, and syndactyly of toe II-III. Exome sequencing revealed a non-frameshift deletion (c.998_1000del:p.Arg333del) of three base pairs in the MEIS2 homeodomain. The more severe phenotype is most probably due to dominant-negative mechanisms. This is the first report showing a de novo small intragenic mutation in MEIS2 and further confirms the important role of this gene in normal development. (c) 2015 Wiley Periodicals, Inc.
C1 [Louw, Jacoba J.; Gewillig, Marc] Univ Hosp Leuven, Dept Congenital & Pediat Cardiol, Leuven, Belgium.
[Louw, Jacoba J.; Corveleyn, Anniek; Jia, Yaojuan; Devriendt, Koenraad] Katholieke Univ Leuven, Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium.
[Hens, Greet] Univ Hosp Leuven, Dept Ear Nose & Throat, Leuven, Belgium.
RP Devriendt, K (reprint author), Ctr Human Genet, Herestr 49, B-3000 Leuven, Belgium.
EM koenraad.devriendt@uzleuven.be
FU H. Van Itterbeek; Eddy Merckx; FU Leuven [GOA/12/015]
FX Grant sponsor: H. Van Itterbeek; Grant sponsor: Eddy Merckx; Grant
sponsor: FU Leuven; Grant number: GOA/12/015.
CR Agoston Z, 2009, DEVELOPMENT, V136, P3311, DOI 10.1242/dev.037770
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Waskiewicz AJ, 2001, DEVELOPMENT, V128, P4139
Zerucha T, 2001, MECH DEVELOP, V102, P247, DOI 10.1016/S0925-4773(01)00299-4
NR 13
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD MAY
PY 2015
VL 167A
IS 5
BP 1142
EP 1146
DI 10.1002/ajmg.a.36989
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA CG3HY
UT WOS:000353171900025
PM 25712757
ER
PT J
AU Doyle-Thomas, KAR
Lee, W
Foster, NEV
Tryfon, A
Ouimet, T
Hyde, KL
Evans, AC
Lewis, J
Zwaigenbaum, L
Anagnostou, E
AF Doyle-Thomas, Krissy A. R.
Lee, Wayne
Foster, Nicholas E. V.
Tryfon, Ana
Ouimet, Tia
Hyde, Krista L.
Evans, Alan C.
Lewis, John
Zwaigenbaum, Lonnie
Anagnostou, Evdokia
CA NeuroDevNet ASD Imaging Grp
TI Atypical Functional Brain Connectivity during Rest in Autism Spectrum
Disorders
SO ANNALS OF NEUROLOGY
LA English
DT Article
ID DEFAULT MODE NETWORK; SENTENCE COMPREHENSION; REVISED VERSION; CORTEX;
UNDERCONNECTIVITY; TASK; FMRI; ABNORMALITIES; COMMUNICATION; HYPOTHESIS
AB ObjectiveConnectivity atypicalities in autism spectrum disorders (ASD) have been extensively proposed. The default mode network (DMN) is critical in this study, given the insight it provides for long-distance connectivity, and the importance of regions in this network for introspection and social emotion processing, areas affected in ASD. However, study of this network has largely been limited to adults; research earlier in development is lacking. The objective of this study was to examine DMN connectivity in children/adolescents with ASD.
MethodsA total of 115 children/adolescents, aged 6 to 17 years (71 males with ASD and 44 group age-matched TD males) were included in these analyses. We examined group differences in (1) functional connectivity between the posterior cingulate cortex and regions across the brain, (2) connectivity within the DMN as a function of age and intelligence quotient (IQ), and (3) the association between DMN connectivity and empathic accuracy.
ResultsIndividuals with ASD, relative to controls, showed either stronger or weaker connectivity between the posterior cingulate cortex (PCC) and DMN regions, depending on the region, but also showed stronger connectivity with non-DMN regions. A significant group-by-age interaction was observed in functional connectivity between the PCC and medial prefrontal cortex; connectivity increased with age in controls, but decreased in individuals with ASD. No effects of IQ were found. There was a significant group difference in the relation between DMN connectivity and empathic accuracy.
InterpretationDifferences in functional connectivity may suggest the presence of neural atypicalities that impact the development of typical connectivity in ASD. In addition to affecting DMN dynamics, these atypicalities may also impact social-cognitive abilities. Ann Neurol 2015;77:866-876
C1 [Doyle-Thomas, Krissy A. R.; Anagnostou, Evdokia] Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, Toronto, ON, Canada.
[Doyle-Thomas, Krissy A. R.; Anagnostou, Evdokia] Univ Toronto, Dept Pediat, Toronto, ON M4G 1R8, Canada.
[Lee, Wayne] Hosp Sick Children, Diagnost Imaging, Toronto, ON M5G 1X8, Canada.
[Foster, Nicholas E. V.; Tryfon, Ana; Ouimet, Tia; Hyde, Krista L.] Univ Montreal, Int Lab Brain Mus & Sound Res, Montreal, PQ, Canada.
[Foster, Nicholas E. V.; Tryfon, Ana; Ouimet, Tia; Hyde, Krista L.] McGill Univ, Fac Med, Montreal, PQ, Canada.
[Evans, Alan C.; Lewis, John] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada.
[Zwaigenbaum, Lonnie] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.
RP Anagnostou, E (reprint author), Univ Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil Hosp, 150 Kilgour Rd, Toronto, ON M4G 1R8, Canada.
EM eanagnostou@hollandbloorview.ca
FU NeuroDevNet
FX This research was supported by NeuroDevNet.
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NR 48
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD MAY
PY 2015
VL 77
IS 5
BP 866
EP 876
DI 10.1002/ana.24391
PG 11
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CG4EF
UT WOS:000353235400014
PM 25707715
ER
PT J
AU Srinivasjois, R
Rao, S
Patole, S
AF Srinivasjois, Ravisha
Rao, Shripada
Patole, Sanjay
TI Probiotic supplementation in children with autism spectrum disorder
SO ARCHIVES OF DISEASE IN CHILDHOOD
LA English
DT Letter
ID NEURODEVELOPMENTAL DISORDERS; MICROBIOTA
C1 [Srinivasjois, Ravisha] Joondalup Hlth Campus, Dept Neonatol & Paediat, Perth, WA 6027, Australia.
[Rao, Shripada] King Edward Mem Hosp Women, Dept Neonatal Paediat, Perth, WA, Australia.
[Patole, Sanjay] Princess Margaret Hosp Children, Dept Neonatal Paediat, Perth, WA, Australia.
RP Srinivasjois, R (reprint author), Joondalup Hlth Campus, Dept Paediat, Specialist Med Ctr, Suite 204, Perth, WA 6027, Australia.
EM srinivasjoisr@ramsayhealth.com.au
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NR 9
TC 0
Z9 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-9888
EI 1468-2044
J9 ARCH DIS CHILD
JI Arch. Dis. Child.
PD MAY
PY 2015
VL 100
IS 5
DI 10.1136/archdischild-2014-308002
PG 2
WC Pediatrics
SC Pediatrics
GA CG3DX
UT WOS:000353159300023
ER
PT J
AU Davidson, J
Gringras, P
Fairhurst, C
Simpson, J
AF Davidson, Joseph
Gringras, Paul
Fairhurst, Charlie
Simpson, John
TI Physical and neurodevelopmental outcomes in children with
single-ventricle circulation
SO ARCHIVES OF DISEASE IN CHILDHOOD
LA English
DT Article
ID LEFT-HEART SYNDROME; QUALITY-OF-LIFE; AUTISM-SPECTRUM;
BRAIN-DEVELOPMENT; NORWOOD PROCEDURE; FONTAN OPERATION; CARDIAC-SURGERY;
GROWTH; PREVALENCE; INFANTS
AB Objective To investigate longer-term physical and neurodevelopmental outcomes of patients with hypoplastic left heart syndrome (HLHS) compared with other patients with functionally single-ventricle circulation surviving beyond the age of 10 years.
Design A retrospective, observational study from a UK tertiary centre for paediatric cardiology.
Results 58 patients with HLHS and 44 non-HLHS patients with single-ventricle physiology were included. Subjective reduction in exercise tolerance was reported in 72% (95% CI 61% to 84%) of patients with HLHS and 45% (31% to 60%) non-HLHS patients. Compared with non-HLHS patients, educational concerns were reported more frequently in patients with HLHS, 41% (29% to 54%) vs 23% (10% to 35%), as was a diagnosis of a behaviour disorder (autism or attention deficit hyperactivity disorder) 12% (4% to 21%) vs 0%, and referral to other specialist services 67% (55% to 79%) vs 48% (33% to 63%).
Conclusions Within a group of young people with complex congenital heart disease, those with HLHS are likely to have worse physical, psychological and educational outcomes.
C1 [Davidson, Joseph] Kings Coll London, Sch Med, London WC2R 2LS, England.
[Gringras, Paul; Fairhurst, Charlie] Guys & St Thomas NHS Fiundat Trust, Evelina London Childrens Hosp, Dept Paediat Neurol, London, England.
[Simpson, John] Guys & St Thomas NHS Fiundat Trust, Evelina London Childrens Hosp, Dept Congenital Heart Dis, London, England.
RP Simpson, J (reprint author), Guys & St Thomas NHS Fdn Trust, Evelina London Childrens Hosp, London SE1 7EH, England.
EM john.simpson@gstt.nhs.uk
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NR 40
TC 0
Z9 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-9888
EI 1468-2044
J9 ARCH DIS CHILD
JI Arch. Dis. Child.
PD MAY
PY 2015
VL 100
IS 5
BP 449
EP 453
DI 10.1136/archdischild-2014-306449
PG 5
WC Pediatrics
SC Pediatrics
GA CG3DX
UT WOS:000353159300010
PM 25480924
ER
PT J
AU Krebs, G
Heyman, I
AF Krebs, Georgina
Heyman, Isobel
TI Obsessive-compulsive disorder in children and adolescents
SO ARCHIVES OF DISEASE IN CHILDHOOD
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIOR THERAPY; SEROTONIN
REUPTAKE INHIBITORS; AUTISM SPECTRUM DISORDERS; PEDIATRIC OCD TREATMENT;
FOLLOW-UP; RESPONSE PREVENTION; TREATMENT-SEEKING; CLINICAL-TRIAL;
MENTAL-HEALTH
AB Obsessive-compulsive disorder (OCD) in childhood and adolescence is an impairing condition, associated with a specific set of distressing symptoms incorporating repetitive, intrusive thoughts (obsessions) and distressing, time-consuming rituals (compulsions). This review considers current knowledge of causes and mechanisms underlying OCD, as well as assessment and treatment. Issues relating to differential diagnosis are summarised, including the challenges of distinguishing OCD from autism spectrum disorders and tic disorders in youth. The recommended treatments, namely cognitive behaviour therapy and serotonin reuptake inhibiting/selective serotonin reuptake inhibitor medications, are outlined along with the existing evidence-based and factors associated with treatment resistance. Finally, novel clinical developments that are emerging in the field and future directions for research are discussed.
C1 [Krebs, Georgina] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England.
[Krebs, Georgina] South London & Maudsley NHS Fdn Trust, OCD & Related Disorder Clin Young People, London, England.
[Heyman, Isobel] Great Ormond St Hosp Sick Children, Psychol Med Team, London WC1N 3JH, England.
[Heyman, Isobel] UCL, Inst Child Hlth, London, England.
RP Krebs, G (reprint author), Maudsley Hosp & Inst Psychiat, OCD & Related Disorders Clin Young People, Denmark Hill, London SE5 8AZ, England.
EM georgina.1.krebs@kcl.ac.uk
FU National Institute for Health Research (NIHR) Mental Health Biomedical
Research Centre at South London; Maudsley NHS Foundation Trust and
King's College London
FX GK receives salary support from the National Institute for Health
Research (NIHR) Mental Health Biomedical Research Centre at South London
and Maudsley NHS Foundation Trust and King's College London. The views
expressed are those of the authors and not necessarily those of the NHS,
the NIHR or the Department of Health.
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NR 56
TC 1
Z9 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-9888
EI 1468-2044
J9 ARCH DIS CHILD
JI Arch. Dis. Child.
PD MAY
PY 2015
VL 100
IS 5
BP 495
EP 499
DI 10.1136/archdischild-2014-306934
PG 5
WC Pediatrics
SC Pediatrics
GA CG3DX
UT WOS:000353159300020
PM 25398447
ER
PT J
AU Moore, DJ
AF Moore, David J.
TI Acute pain experience in individuals with autism spectrum disorders: A
review
SO AUTISM
LA English
DT Review
DE autism spectrum disorder; autism; autistic; pain; sensory differences
ID TACTILE PERCEPTION; INFANTILE-AUTISM; BETA-ENDORPHIN; CHILDREN; ADULTS;
ABNORMALITIES; COMMUNICATION; ADOLESCENTS; EXPRESSION; CHILDHOOD
AB In addition to the diagnostic criteria for autism spectrum disorder, a number of clinically important comorbid complaints, including sensory abnormalities, are also discussed. One difference often noted in these accounts is hyposensitivity to pain; however, evidence for this is limited. The purpose of the current review therefore was to examine sensitivity to pain of individuals with autism spectrum disorder. This review is interested in reports which consider differences in subjective experience of pain (i.e. different pain thresholds) and differences in behavioural response to pain (i.e. signs of pain-related distress). Studies were included if they were conducted with human subjects, included a clearly diagnosed autism spectrum disorder population and reported data pertaining to pain experience relative to the neurotypical population. Studies were classified as being self/parent report, clinical observations, observations of response to medical procedures or experimental examination of pain. Both self/parent report and clinical observations appeared to report hyposensitivity to pain, whereas observations of medical procedures and experimental manipulation suggested normal or hypersensitive responses to pain. This review suggests that contrary to classical reports, individuals with autism spectrum disorder do not appear to have systematically altered pain responses or thresholds. More systematic experimental examination of this area is needed to understand responses to pain of individuals with autism spectrum disorder.
C1 [Moore, David J.] Liverpool John Moores Univ, Liverpool L3 3AF, Merseyside, England.
RP Moore, DJ (reprint author), Liverpool John Moores Univ, Dept Nat Sci & Psychol, Liverpool L3 3AF, Merseyside, England.
EM D.J.Moore@ljmu.ac.uk
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NR 65
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 387
EP 399
DI 10.1177/1362361314527839
PG 13
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100001
PM 24687688
ER
PT J
AU Sizoo, BB
van der Gaag, RJ
van den Brink, W
AF Sizoo, Bram B.
van der Gaag, Rutger Jan
van den Brink, Wim
TI Temperament and character as endophenotype in adults with autism
spectrum disorders or attention deficit/hyperactivity disorder
SO AUTISM
LA English
DT Article
DE attention deficit/hyperactivity disorder; autism spectrum quotient;
autism; character; endophenotype; personality; temperament
ID DEFICIT-HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS;
SUBSTANCE USE DISORDERS; PERSONALITY-TRAITS; PSYCHOBIOLOGICAL MODEL;
QUOTIENT AQ; ADHD; COMORBIDITY; RELIABILITY; DYSFUNCTION
AB Autism spectrum disorder and attention deficit/hyperactivity disorder overlap in several ways, raising questions about the nature of this comorbidity. Rommelse et al. published an innovative review of candidate endophenotypes for autism spectrum disorder and attention deficit/hyperactivity disorder in cognitive and brain domains. They found that all the endophenotypic impairments that were reviewed in attention deficit/hyperactivity disorder were also present in autism spectrum disorder, suggesting a continuity model with attention deficit/hyperactivity disorder as a light form of autism spectrum disorder. Using existing data, 75 adults with autism spectrum disorder and 53 with attention deficit/hyperactivity disorder were directly compared on autistic symptoms with the autism spectrum quotient, and on the endophenotypic measure of temperament and character, using the Abbreviated (Dutch: Verkorte) Temperament and Character Inventory. Based on the hypothesis that attention deficit/hyperactivity disorder and autism spectrum disorder are disorders on a continuous spectrum, autism spectrum quotient scores and abbreviated Temperament and Character Inventory scores were expected to be different from normal controls in both disorders in a similar direction. In addition, the autism spectrum quotient and abbreviated Temperament and Character Inventory scores were expected to be closely correlated. These conditions applied to only two of the seven Abbreviated Temperament and Character Inventory scales (harm avoidance and self-directedness), suggesting that temperament and character as an endophenotype of autism spectrum disorder and attention deficit/hyperactivity disorder provides only partial support for the continuity hypothesis of autism spectrum disorder and attention deficit/hyperactivity disorder.
C1 [Sizoo, Bram B.] Dimence, Ctr Dev Disorders, NL-7400 GC Deventer, Netherlands.
[van der Gaag, Rutger Jan] Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands.
[van den Brink, Wim] Univ Amsterdam, Acad Med Ctr, NL-1012 WX Amsterdam, Netherlands.
RP Sizoo, BB (reprint author), Dimence, Ctr Dev Disorders, POB 5003, NL-7400 GC Deventer, Netherlands.
EM b.sizoo@dimence.nl
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Wheelwright S, 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-1.PUBMED:20678244
NR 49
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 400
EP 408
DI 10.1177/1362361314522352
PG 9
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100002
PM 24535690
ER
PT J
AU Bonete, S
Calero, MD
Fernandez-Parra, A
AF Bonete, Saray
Dolores Calero, Maria
Fernandez-Parra, Antonio
TI Group training in interpersonal problem-solving skills for workplace
adaptation of adolescents and adults with Asperger syndrome: A
preliminary study
SO AUTISM
LA English
DT Article
DE adults; Asperger syndrome; autism spectrum disorders; group
intervention; social problem-solving training; workplace adaptation
ID AUTISM SPECTRUM DISORDERS; INTERVENTION; MEDIATOR; CHILDREN; ANXIETY;
STRESS
AB Adults with Asperger syndrome show persistent difficulties in social situations which psychosocial treatments may address. Despite the multiple studies focusing on social skills interventions, only some have focused specifically on problem-solving skills and have not targeted workplace adaptation training in the adult population. This study describes preliminary data from a group format manual-based intervention, the Interpersonal Problem-Solving for Workplace Adaptation Programme, aimed at improving the cognitive and metacognitive process of social problem-solving skills focusing on typical social situations in the workplace based on mediation as the main strategy. A total of 50 adults with Asperger syndrome received the programme and were compared with a control group of typical development. The feasibility and effectiveness of the treatment were explored. Participants were assessed at pre-treatment and post-treatment on a task of social problem-solving skills and two secondary measures of socialisation and work profile using self- and caregiver-report. Using a variety of methods, the results showed that scores were significantly higher at post-treatment in the social problem-solving task and socialisation skills based on reports by parents. Differences in comparison to the control group had decreased after treatment. The treatment was acceptable to families and subject adherence was high. The Interpersonal Problem-Solving for Workplace Adaptation Programme appears to be a feasible training programme.
C1 [Bonete, Saray; Dolores Calero, Maria; Fernandez-Parra, Antonio] Univ Granada, E-18071 Granada, Spain.
[Bonete, Saray] Univ Francisco Vitoria, Madrid 28223, Spain.
RP Bonete, S (reprint author), Univ Francisco Vitoria, Ctra Pozuelo Majadahonda Km 1-800, Madrid 28223, Spain.
EM s.bonete.prof@ufv.es
FU University of Granada FPU Plan Propio grant
FX This project was partially supported by the University of Granada FPU
Plan Propio grant.
CR American Psychiatric Association (APA), 2000, DIAGN STAT MAN MENTT
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NR 45
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 409
EP 420
DI 10.1177/1362361314522354
PG 12
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100003
PM 24569569
ER
PT J
AU Walton, KM
Ingersoll, BR
AF Walton, Katherine M.
Ingersoll, Brooke R.
TI The influence of maternal language responsiveness on the expressive
speech production of children with autism spectrum disorders: A
microanalysis of mother-child play interactions
SO AUTISM
LA English
DT Article
DE autism spectrum disorders; responsiveness; speech
ID PARENT VERBAL RESPONSIVENESS; JOINT ATTENTION; COMMUNICATION;
INTERVENTION; BEHAVIORS; PRESCHOOLERS; ABILITIES; TODDLERS; STIMULI;
PREDICT
AB Adult responsiveness is related to language development both in young typically developing children and in children with autism spectrum disorders, such that parents who use more responsive language with their children have children who develop better language skills over time. This study used a micro-analytic technique to examine how two facets of maternal utterances, relationship to child focus of attention and degree of demandingness, influenced the immediate use of appropriate expressive language of preschool-aged children with autism spectrum disorders (n = 28) and toddlers with typical development (n = 16) within a naturalistic mother-child play session. Mothers' use of follow-in demanding language was most likely to elicit appropriate expressive speech in both children with autism spectrum disorders and children with typical development. For children with autism spectrum disorders, but not children with typical development, mothers' use of orienting cues conferred an additional benefit for expressive speech production. These findings are consistent with the naturalistic behavioral intervention philosophy and suggest that following a child's lead while prompting for language is likely to elicit speech production in children with autism spectrum disorders and children with typical development. Furthermore, using orienting cues may help children with autism spectrum disorders to verbally respond.
C1 [Walton, Katherine M.; Ingersoll, Brooke R.] Michigan State Univ, E Lansing, MI 48824 USA.
RP Walton, KM (reprint author), Michigan State Univ, 316 Phys Rd,Psychol Bldg Room 69F, E Lansing, MI 48824 USA.
EM Ktmeyer15@gmail.com
CR Aldred C, 2004, J CHILD PSYCHOL PSYC, V45, P1420, DOI 10.1111/j1469-7610.2004.00338.x
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Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th
NR 37
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 421
EP 432
DI 10.1177/1362361314523144
PG 12
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100004
PM 24566717
ER
PT J
AU Gjevik, E
Sandstad, B
Andreassen, OA
Myhre, AM
Sponheim, E
AF Gjevik, Elen
Sandstad, Berit
Andreassen, Ole A.
Myhre, Anne M.
Sponheim, Eili
TI Exploring the agreement between questionnaire information and DSM-IV
diagnoses of comorbid psychopathology in children with autism spectrum
disorders
SO AUTISM
LA English
DT Article
DE autism spectrum disorders; children; Child Behavior Check List; DSM-IV
disorders; psychiatric comorbidity
ID PERVASIVE DEVELOPMENTAL DISORDERS; HIGH-FUNCTIONING AUTISM;
PSYCHIATRIC-DISORDERS; BEHAVIOR CHECKLIST; ASPERGER-SYNDROME;
YOUNG-PEOPLE; INTERVIEW; VALIDITY; ANXIETY; ADOLESCENTS
AB Autism spectrum disorders are often comorbid with other psychiatric symptoms and disorders. However, identifying psychiatric comorbidity in children with autism spectrum disorders is challenging. We explored how a questionnaire, the Child Behavior Check List, agreed with a Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV)-based semi-structured interview, the Kiddie-Schedule for Affective Disorders and Schizophrenia for School-Age Children (Kiddie-SADS). The sample comprised 55 children and adolescents (age 6 to 18 years) with autism spectrum disorders, including the main autism spectrum disorder subgroups and the broad range of cognitive and language functioning. High rate of psychopathology was found both through questionnaire and interview assessment. Using predefined Child Behavior Check List cutoffs, we found good agreement between the Child Behavior Check List and the Kiddie-SADS for identifying attention deficit/hyperactivity disorder, depressive disorders, and oppositional defiant disorder. However, overall the specificity of the Child Behavior Check List was low. The Child Behavior Check List was not useful for identifying anxiety disorders. The Child Behavior Check List may capture core symptoms of autism spectrum disorders as well as comorbid psychopathology, and clinicians should be aware that the Child Behavior Check List may be unspecific when used in children and adolescents with autism spectrum disorders.
C1 [Gjevik, Elen; Andreassen, Ole A.; Myhre, Anne M.; Sponheim, Eili] Oslo Univ Hosp, N-0424 Oslo, Norway.
[Gjevik, Elen; Sandstad, Berit; Andreassen, Ole A.; Myhre, Anne M.] Univ Oslo, N-0316 Oslo, Norway.
RP Gjevik, E (reprint author), Oslo Univ Hosp, Div Mental Hlth & Addict, Res Unit, POB 4959, N-0424 Oslo, Norway.
EM elen.gjevik@medisin.uio.no
FU University of Oslo; Oslo University Hospital; Research Council of Norway
[213694]
FX The current project was funded by the University of Oslo, Oslo
University Hospital, and the Research Council of Norway (#213694).
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
Antshel KM, 2011, J DEV BEHAV PEDIATR, V32, P439, DOI 10.1097/DBP.0b013e318222355d
Bellina M, 2013, EUR CHILD ADOLES PSY, V22, P235, DOI 10.1007/s00787-012-0343-0
Biederman J, 2010, J DEV BEHAV PEDIATR, V31, P485, DOI 10.1097/DBP.0b013e3181e56ddd
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NR 39
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 433
EP 442
DI 10.1177/1362361314526003
PG 10
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100005
PM 24637430
ER
PT J
AU Andersen, PN
Skogli, EW
Hovik, KT
Geurts, H
Egeland, J
Oie, M
AF Andersen, Per N.
Skogli, Erik W.
Hovik, Kjell T.
Geurts, Hilde
Egeland, Jens
Oie, Merete
TI Working memory arrest in children with high-functioning autism compared
to children with attention-deficit/hyperactivity disorder: Results from
a 2-year longitudinal study
SO AUTISM
LA English
DT Article
DE Asperger's syndrome; attention-deficit; hyperactivity disorder; autism
spectrum disorder; development; pervasive developmental disorder-not
otherwise specified; working memory
ID SCHOOL-AGE-CHILDREN; EXECUTIVE FUNCTION; SPECTRUM DISORDERS;
ASPERGER-SYNDROME; DEVELOPMENTAL DISORDERS; TOTAL POPULATION;
ADOLESCENTS; ADHD; SCHIZOPHRENIA; RELIABILITY
AB The aim of this study was to analyse the development of verbal working memory in children with high-functioning autism compared to children with attention-deficit/hyperactivity disorder and typically developing children. A total of 34 children with high-functioning autism, 72 children with attention-deficit/hyperactivity disorder and 45 typically developing children (age 9-16 years) were included at baseline and followed up approximately 25 months later. The children were given a letter/number sequencing task to assess verbal working memory. The performance of children with high-functioning autism on verbal working memory did not improve after 2 years, while improvement was observed in children with attention-deficit/hyperactivity disorder and typically developing children. The results indicate a different developmental trajectory for verbal working memory in children with high-functioning autism compared to children with attention-deficit/hyperactivity disorder and typically developing children. More research is needed to construct a developmental framework more suitable for children with autism spectrum disorder.
C1 [Andersen, Per N.; Skogli, Erik W.; Hovik, Kjell T.; Oie, Merete] Innlandet Hosp Trust, N-2629 Lillehammer, Norway.
[Andersen, Per N.; Skogli, Erik W.; Hovik, Kjell T.; Oie, Merete] Univ Oslo, N-0316 Oslo, Norway.
[Geurts, Hilde] Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands.
[Geurts, Hilde] Dr Leo Kannerhuis, Nijmegen, Netherlands.
[Egeland, Jens] Vestfold Hosp Trust, Tonsberg, Norway.
RP Andersen, PN (reprint author), Innlandet Hosp Trust, Div Mental Hlth Care, N-2629 Lillehammer, Norway.
EM pernoan@gmail.com
FU Innlandet Hospital Trust [150170]; Regional Resource Center for Autism,
ADHD, Tourette's syndrome and Narcolepsy, Oslo University Hospital
[150182]
FX The work was supported by grants from Innlandet Hospital Trust (grant
number 150170) and from Regional Resource Center for Autism, ADHD,
Tourette's syndrome and Narcolepsy, Oslo University Hospital (grant
number 150182).
CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE
Alloway TP, 2009, J LEARN DISABIL-US, V42, P372, DOI 10.1177/0022219409335214
American Psychiatric Association APA, 2013, DIAGN STAT MAN MENT, V5th
Andersen PN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064842
Antshel KM, 2011, J DEV BEHAV PEDIATR, V32, P439, DOI 10.1097/DBP.0b013e318222355d
(APA) APA, 2000, DIAGN STAT MAN MENT
Baddeley A, 2003, NAT REV NEUROSCI, V4, P829, DOI 10.1038/nrn1201
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Wechsler D, 1999, WECHSLER ABBREVIATED
NR 48
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 443
EP 450
DI 10.1177/1362361314524844
PG 8
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100006
PM 24604922
ER
PT J
AU Cleary, L
Brady, N
Fitzgerald, M
Gallagher, L
AF Cleary, Laura
Brady, Nuala
Fitzgerald, Michael
Gallagher, Louise
TI Holistic processing of faces as measured by the Thatcher illusion is
intact in autism spectrum disorders
SO AUTISM
LA English
DT Article
DE autism spectrum disorders; configural processing; face perception;
inversion effects; Thatcher illusion
ID PERCEPTION; INTELLIGENCE; INDIVIDUALS; ROTATION; CHILDREN; VERSION;
LEVEL
AB Impaired face perception in autism spectrum disorders is thought to reflect a perceptual style characterized by componential rather than configural processing of faces. This study investigated face processing in adolescents with autism spectrum disorders using the Thatcher illusion, a perceptual phenomenon exhibiting inversion effects' that characterize typical face processing. While previous studies used a limited range of face orientations, we measured perception of normality/grotesqueness of faces at seven orientations ranging from upright to inverted to allow for a detailed comparison of both reaction time and error by orientation profiles. We found that, like their typically developing peers, adolescents with autism spectrum disorders show strong inversion effects whereby reaction times were longer and error rates greater at inverted when compared to upright orientations. Additionally, the adolescents with autism spectrum disorders, like their peers in the typically developing group, show a marked nonlinearity in the error by orientation profile. Error is roughly constant out to 90 degrees and then increases steeply, indicating a sudden shift from configural to local processing that reflects experience with faces in their typical orientations. These findings agree with recent reports that face perception is qualitatively similar in autistic and neurotypical groups.
C1 [Cleary, Laura; Brady, Nuala] Natl Univ Ireland Univ Coll Dublin, Dublin 4, Ireland.
[Fitzgerald, Michael; Gallagher, Louise] Univ Dublin Trinity Coll, Dublin 2, Ireland.
RP Brady, N (reprint author), Natl Univ Ireland Univ Coll Dublin, Sch Psychol, Dublin 4, Ireland.
EM nuala.brady@ucd.ie
CR Allen H, 2009, PERCEPTION, V38, P1821, DOI 10.1068/p6424
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NR 31
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 451
EP 458
DI 10.1177/1362361314526005
PG 8
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100007
PM 24637429
ER
PT J
AU Schuwerk, T
Vuori, M
Sodian, B
AF Schuwerk, Tobias
Vuori, Maria
Sodian, Beate
TI Implicit and explicit Theory of Mind reasoning in autism spectrum
disorders: The impact of experience
SO AUTISM
LA English
DT Article
DE anticipatory looking; autism spectrum disorders; Theory of Mind
ID STRANGE STORIES TEST; ASPERGER-SYNDROME; FALSE BELIEF; ACTION
ANTICIPATION; SOCIAL COGNITION; ADULTS; CHILDRENS; ABSENCE; ATTRIBUTION;
REPLICATION
AB This study aimed to investigate the relationship between explicit and implicit forms of Theory of Mind reasoning and to test the influence of experience on implicit Theory of Mind reasoning in individuals with autism spectrum disorders and in neurotypical adults. Results from two standard explicit Theory of Mind tasks are mixed: Individuals with autism spectrum disorders did not differ from neurotypical adults in their performance in the Strange Stories Test, but scored significantly lower on the Reading the Mind in the Eyes Test. Furthermore, in an implicit false-belief task, individuals with autism spectrum disorders differed from neurotypical adults in false belief-congruent anticipatory looking. However, this group difference disappeared by (1) providing participants with the outcome of a false belief-based action and (2) subsequently repeating this test trial. Although the tendency to fixate the false belief-congruent location significantly increased from the first to the second test trial in individuals with autism spectrum disorders, it differed in neither test trial from chance. These findings support the notion of an implicit Theory of Mind deficit in autism spectrum disorders, but give rise to the idea that anticipatory looking behaviors in autism spectrum disorders may be affected by experience. Additionally, the pattern of results from implicit and explicit Theory of Mind measures supports the theory of two independent Theory of Mind reasoning systems.
C1 [Schuwerk, Tobias; Vuori, Maria; Sodian, Beate] Univ Munich, D-80802 Munich, Germany.
RP Schuwerk, T (reprint author), Univ Munich, Dept Psychol, Leopoldstr 13, D-80802 Munich, Germany.
EM tobias.schuwerk@psy.lmu.de
FU Volkswagen Foundation (Research group "The social brain")
FX This research was funded by a grant from the Volkswagen Foundation
(Research group "The social brain").
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NR 36
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 459
EP 468
DI 10.1177/1362361314526004
PG 10
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100008
PM 24627427
ER
PT J
AU Mastrogiuseppe, M
Capirci, O
Cuva, S
Venuti, P
AF Mastrogiuseppe, Marilina
Capirci, Olga
Cuva, Simone
Venuti, Paola
TI Gestural communication in children with autism spectrum disorders during
mother-child interaction
SO AUTISM
LA English
DT Article
DE autism; gestures; parent-child interaction
ID PERVASIVE DEVELOPMENTAL DISORDERS; TYPICALLY DEVELOPING-CHILDREN; JOINT
ATTENTION; DOWN-SYNDROME; YOUNG-CHILDREN; LANGUAGE-DEVELOPMENT;
INFANTILE-AUTISM; EMERGENCE; AGREEMENT; SPEECH
AB Children with autism spectrum disorders display atypical development of gesture production, and gesture impairment is one of the determining factors of autism spectrum disorder diagnosis. Despite the obvious importance of this issue for children with autism spectrum disorder, the literature on gestures in autism is scarce and contradictory. The purpose of this study was to analyze gestural communication in children with autism spectrum disorder during spontaneous mother-child interaction. Participants were children with autism spectrum disorder (n = 20), Down's syndrome (n = 20), and typical development (n = 20) and their mothers. Children's mean developmental age was 24.16 months (standard deviation = 1.45 months) and did not differ across the groups. Gestural communication was analyzed with a specific coding scheme allowing a quantitative and qualitative analysis of gestural production. Results showed the following: (a) differences between autism spectrum disorder, typical development, and Down's syndrome groups in the total number of gestures produced; (b) differences between the three groups in the distribution of gesture types; and (c) specific correlations between gestural production, cognitive development, and autism severity scores. The study of gestures in autism spectrum disorder could help us to identify different phenotypes in autism and could also lead to the development of new therapies.
C1 [Mastrogiuseppe, Marilina; Cuva, Simone; Venuti, Paola] Univ Trento, I-38068 Rovereto, TN, Italy.
[Capirci, Olga] CNR, ISTC, I-00185 Rome, Italy.
RP Mastrogiuseppe, M (reprint author), Univ Trento, Dept Psychol & Cognit Sci, Via Matteo dal Ben 5 B, I-38068 Rovereto, TN, Italy.
EM m.mastrogiuseppe-1@unitn.it
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NR 60
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 469
EP 481
DI 10.1177/1362361314528390
PG 13
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100009
PM 24699229
ER
PT J
AU Muskat, B
Riosa, P
Nicholas, DB
Roberts, W
Stoddart, KP
Zwaigenbaum, L
AF Muskat, Barbara
Burnham Riosa, Priscilla
Nicholas, David B.
Roberts, Wendy
Stoddart, Kevin P.
Zwaigenbaum, Lonnie
TI Autism comes to the hospital: The experiences of patients with autism
spectrum disorder, their parents and health-care providers at two
Canadian paediatric hospitals
SO AUTISM
LA English
DT Article
DE autism spectrum disorder; health care; hospital; medical; paediatric;
qualitative methods
ID DEVELOPMENTAL-DISABILITIES; MEDICAL CONDITIONS; CHILDREN; MANAGEMENT;
EXPENDITURES; ADOLESCENTS; BEHAVIOR
AB Youth with autism spectrum disorder are a vulnerable, often poorly understood patient group, who may experience periodic and chronic health challenges, in addition to their primary developmental social and communication problems. Developmental and behavioural challenges can complicate management of acute health-care needs. To date, there is an absence of empirical research exploring the hospital experiences of children and youth with autism spectrum disorder, their families and their health-care providers. Therefore, the purpose of this study was to understand these experiences in order to inform hospital-based care. A total of 42 participants were interviewed (youth with autism spectrum disorder, their parents and health-care providers) at one of two Canadian paediatric hospitals, representing 20 distinct cases of patients with autism spectrum disorder. Results from the qualitative analyses indicated that patients with autism spectrum disorder faced several challenges in the context of health-care delivery in the hospital setting, as did their families and health-care provider team. Problems identified included communication and sensory challenges, and the degree of flexibility of health-care providers and the hospital organization. Supportive health-care providers were those who acknowledged parents as experts, inquired about the requirements of patients with autism spectrum disorder and implemented strategies that accommodated the unique clinical presentation of the individual patient. These recommendations have wide-reaching utility for hospital and health-care practices involving this patient group.
C1 [Muskat, Barbara; Burnham Riosa, Priscilla; Roberts, Wendy] Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
[Muskat, Barbara; Roberts, Wendy; Stoddart, Kevin P.] Univ Toronto, Toronto, ON M5S 1A1, Canada.
[Nicholas, David B.] Univ Calgary, Calgary, AB T2N 1N4, Canada.
[Stoddart, Kevin P.] Redpath Ctr, Toronto, ON, Canada.
[Zwaigenbaum, Lonnie] Univ Alberta, Edmonton, AB T6G 2M7, Canada.
[Zwaigenbaum, Lonnie] Glenrose Rehabil Hosp, Edmonton, AB, Canada.
RP Muskat, B (reprint author), Hosp Sick Children, Dept Social Work, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM barbara.muskat@sickkids.ca
FU SickKids Foundation
FX This research was funded by a New Investigator Grant from SickKids
Foundation.
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NR 41
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 482
EP 490
DI 10.1177/1362361314531341
PG 9
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100010
PM 24811967
ER
PT J
AU Gotham, K
Unruh, K
Lord, C
AF Gotham, Katherine
Unruh, Kathryn
Lord, Catherine
TI Depression and its measurement in verbal adolescents and adults with
autism spectrum disorder
SO AUTISM
LA English
DT Article
DE Adult Behavior Checklist; Adult Self-Report; autism spectrum disorder;
Beck Depression Inventory; depression; self-report
ID HIGH-FUNCTIONING ADOLESCENTS; ASPERGER-SYNDROME; MENTAL-RETARDATION;
PSYCHOMETRIC PROPERTIES; PSYCHIATRIC-DISORDERS; CHILDREN; SYMPTOMS;
ANXIETY; PEOPLE; EPIDEMIOLOGY
AB In a sample of 50 verbally fluent adolescents and adults with autism spectrum disorders (age: 16-31 years; verbal IQ: 72-140), we examined the pattern of response and associations between scores on common measures of depressive symptoms, participant characteristics, and clinical diagnosis of depressive disorders. Beck Depression Inventory-Second Edition item descriptives in this autism spectrum disorder sample were compared to previously published data from a large typically developing sample, with results suggesting that cognitive-attributional symptoms of depression may be particularly prevalent in autism spectrum disorder. Scores on a variety of self- and parent-report depression measures were not associated with chronological age or verbal IQ, and were relatively highly correlated with each other and with clinical diagnosis of a mood disorder. The Beck Depression Inventory-Second Edition and the Adult Self-Report Depressive scale best identified both depressed and non-depressed participants in this sample, though neither was particularly strong. Validation studies of depression measures in the autism spectrum disorder population are necessary to advance research into this prevalent and impairing comorbidity.
C1 [Gotham, Katherine] Vanderbilt Univ, Med Ctr, Nashville, TN 37232 USA.
[Unruh, Kathryn] Vanderbilt Univ, Nashville, TN 37232 USA.
[Lord, Catherine] Weill Cornell Med Coll, New York, NY USA.
RP Gotham, K (reprint author), Vanderbilt Univ, Med Ctr, Vanderbilt Bill Wilkerson Ctr, 1215,21st Ave S,Room 10233, Nashville, TN 37232 USA.
EM katherine.gotham@vanderbilt.edu
FU National Institutes of Health [MH57167, MH066469, T32-MH18921,
R01MH081873-01A1]; Rackham Graduate School; Blue Cross Blue Shield of
Michigan Foundation
FX This work was supported by the National Institutes of Health (grant
numbers MH57167, MH066469, T32-MH18921, R01MH081873-01A1, Rackham
Graduate School, and the Blue Cross Blue Shield of Michigan Foundation.
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NR 53
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 491
EP 504
DI 10.1177/1362361314536625
PG 14
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100011
PM 24916450
ER
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LA English
DT Article
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NR 8
TC 0
Z9 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1362-3613
EI 1461-7005
J9 AUTISM
JI Autism
PD MAY
PY 2015
VL 19
IS 4
BP 505
EP 507
DI 10.1177/1362361314562617
PG 3
WC Psychology, Developmental
SC Psychology
GA CG1IK
UT WOS:000353026100012
PM 25694585
ER
PT J
AU Utami, KH
AF Utami, K. H.
TI The implications of de novo coding mutations in simplex autism families
SO CLINICAL GENETICS
LA English
DT Editorial Material
ID SPECTRUM
C1 [Utami, K. H.] Translat Lab Genet Med TLGM, Agcy Sci, Res & Technol, Singapore, Singapore.
RP Utami, KH (reprint author), Translat Lab Genet Med TLGM, Agcy Sci, Res & Technol, Singapore, Singapore.
RI ahmed, Jamila/E-8653-2015
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NR 4
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-9163
EI 1399-0004
J9 CLIN GENET
JI Clin. Genet.
PD MAY
PY 2015
VL 87
IS 5
BP 428
EP 429
DI 10.1111/cge.12582
PG 2
WC Genetics & Heredity
SC Genetics & Heredity
GA CF8GS
UT WOS:000352794800005
PM 25753786
ER
PT J
AU Lane, RD
Hsu, CH
Locke, DEC
Ritenbaugh, C
Stonnington, CM
AF Lane, Richard D.
Hsu, Chiu-Hsieh
Locke, Dona E. C.
Ritenbaugh, Cheryl
Stonnington, Cynthia M.
TI Role of theory of mind in emotional awareness and alexithymia:
Implications for conceptualization and measurement
SO CONSCIOUSNESS AND COGNITION
LA English
DT Article
DE Theory of mind; Alexithymia; Affective agnosia; Emotional awareness;
Somatic symptom disorders
ID ASPERGER-SYNDROME; AUTISM; SCALE; SOMATIZATION; RECOGNITION; VALIDATION;
DEPRESSION; SELF
AB The goal of this study was to determine whether alexithymia, which is characterized by difficulty in recognizing and describing emotions, is associated with impairments in the ability to mentally represent emotional states. We studied 89 outpatients including 29 conversion disorder patients, 30 functional somatic syndrome [e.g. fibromyalgia] patients and 30 medical controls.
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[Ritenbaugh, Cheryl] Univ Arizona, Dept Family & Community Med, Tucson, AZ 85724 USA.
RP Lane, RD (reprint author), Univ Arizona, Dept Psychiat, 1501 N Campbell Ave, Tucson, AZ 85724 USA.
EM lane@email.arizona.edu
FU Institute for Mental Health Research [2008-LR-804]; Mayo Clinic
[08-001718]
FX Institute for Mental Health Research (Grant #2008-LR-804, Drs. Lane and
Stonnington) and Mayo Clinic (08-001718, Dr. Stonnington).
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NR 46
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8100
EI 1090-2376
J9 CONSCIOUS COGN
JI Conscious. Cogn.
PD MAY
PY 2015
VL 33
BP 398
EP 405
DI 10.1016/j.concog.2015.02.004
PG 8
WC Psychology, Experimental
SC Psychology
GA CG0AA
UT WOS:000352927800036
PM 25766906
ER
PT J
AU McMahon, CM
Henderson, HA
AF McMahon, Camilla M.
Henderson, Heather A.
TI Error-monitoring in response to social stimuli in individuals with
higher-functioning Autism Spectrum Disorder
SO DEVELOPMENTAL SCIENCE
LA English
DT Article
ID BRAIN ACTIVITY; SCREENING QUESTIONNAIRE; DIAGNOSTIC INTERVIEW; SOURCE
LOCALIZATION; COGNITIVE CONTROL; ASPERGER-SYNDROME; REVISED VERSION; ERP
COMPONENTS; EYES TEST; CHILDREN
AB Error-monitoring, or the ability to recognize one's mistakes and implement behavioral changes to prevent further mistakes, may be impaired in individuals with Autism Spectrum Disorder (ASD). Children and adolescents (ages 9-19) with ASD (n = 42) and typical development (n = 42) completed two face processing tasks that required discrimination of either the gender or affect of standardized face stimuli. Post-error slowing and the difference in Error-Related Negativity amplitude between correct and incorrect responses (ERNdiff) were used to index error-monitoring ability. Overall, ERNdiff increased with age. On the Gender Task, individuals with ASD had a smaller ERNdiff than individuals with typical development; however, on the Affect Task, there were no significant diagnostic group differences on ERNdiff. Individuals with ASD may have ERN amplitudes similar to those observed in individuals with typical development in more social contexts compared to less social contexts due to greater consequences for errors, more effortful processing, and/or reduced processing efficiency in these contexts. Across all participants, more post-error slowing on the Affect Task was associated with better social cognitive skills.
C1 [McMahon, Camilla M.] 3C Inst, Cary, NC 27513 USA.
[Henderson, Heather A.] Univ Waterloo, Dept Psychol, Waterloo, ON N2L 3G1, Canada.
RP McMahon, CM (reprint author), 3C Inst, 1901 N Harrison Ave,Suite 200, Cary, NC 27513 USA.
EM camillam@live.com
FU National Institute of Health (NIH) [R01MH071273, T32MH073124]; Institute
of Education Sciences, US Department of Education [DED-R305C050052]
FX This research was supported by the National Institute of Health (NIH),
through Grants R01MH071273 and T32MH073124, and the Institute of
Education Sciences, US Department of Education, through Grant
DED-R305C050052. The opinions expressed are those of the authors and do
not represent views of NIH or the US Department of Education. The
authors thank Michael Alessandri, Jessica Alvarez, Alexis Bitting, Diana
Borrero, Jeffrey Brosco, Elektra Burgos, Jessica Cardenas, Raphaelle
Cuenod, Irene Daboin, Cristina De Armas, Stephanie Dickinson, Michaela
Gaffley, Bridget Gamber, Allyson Hodgkins, Mark Jaime, Nicole Kojkowski,
Krystal Lago, Peggy Laguerre, Javier Lopez-Calderon, Adam McMahon,
Daniel Messinger, Leena Mohapatra, Lisa Newell, Kimie Ono, Jessica
Smolarz, and Marygrace Yale-Kaiser for their contributions.
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NR 71
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1363-755X
EI 1467-7687
J9 DEVELOPMENTAL SCI
JI Dev. Sci.
PD MAY
PY 2015
VL 18
IS 3
BP 389
EP 403
DI 10.1111/desc.12220
PG 15
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA CG1SJ
UT WOS:000353054000003
PM 25066088
ER
PT J
AU Popp, B
Stove, SI
Endele, S
Myklebust, LM
Hoyer, J
Sticht, H
Azzarello-Burri, S
Rauch, A
Arnesen, T
Reis, A
AF Popp, Bernt
Stove, Svein I.
Endele, Sabine
Myklebust, Line M.
Hoyer, Juliane
Sticht, Heinrich
Azzarello-Burri, Silvia
Rauch, Anita
Arnesen, Thomas
Reis, Andre
TI De novo missense mutations in the NAA10 gene cause severe non-syndromic
developmental delay in males and females
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID N-TERMINAL ACETYLTRANSFERASE; LENZ MICROPHTHALMIA SYNDROME; AUTISM
SPECTRUM DISORDERS; COFFIN-LOWRY-SYNDROME; ALPHA-ACETYLTRANSFERASE;
INTELLECTUAL DISABILITY; SEQUENCING DATA; HUMAN GENOME; COMPLEX; ARD1
AB Recent studies revealed the power of whole-exome sequencing to identify mutations in sporadic cases with non-syndromic intellectual disability. We now identified de novo missense variants in NAA10 in two unrelated individuals, a boy and a girl, with severe global developmental delay but without any major dysmorphism by trio whole-exome sequencing. Both de novo variants were predicted to be deleterious, and we excluded other variants in this gene. This X-linked gene encodes N-alpha-acetyltransferase 10, the catalytic subunit of the NatA complex involved in multiple cellular processes. A single hypomorphic missense variant p.(Ser37Pro) was previously associated with Ogden syndrome in eight affected males from two different families. This rare disorder is characterized by a highly recognizable phenotype, global developmental delay and results in death during infancy. In an attempt to explain the discrepant phenotype, we used in vitro N-terminal acetylation assays which suggested that the severity of the phenotype correlates with the remaining catalytic activity. The variant in the Ogden syndrome patients exhibited a lower activity than the one seen in the boy with intellectual disability, while the variant in the girl was the most severe exhibiting only residual activity in the acetylation assays used. We propose that N-terminal acetyltransferase deficiency is clinically heterogeneous with the overall catalytic activity determining the phenotypic severity.
C1 [Popp, Bernt; Endele, Sabine; Hoyer, Juliane; Reis, Andre] Univ Erlangen Nurnberg, Inst Human Genet, D-91054 Erlangen, Germany.
[Stove, Svein I.; Myklebust, Line M.; Arnesen, Thomas] Univ Bergen, Dept Mol Biol, Bergen, Norway.
[Stove, Svein I.; Arnesen, Thomas] Haukeland Hosp, Dept Surg, N-5021 Bergen, Norway.
[Sticht, Heinrich] Univ Erlangen Nurnberg, Inst Biochem, D-91054 Erlangen, Germany.
[Azzarello-Burri, Silvia; Rauch, Anita] Univ Zurich, Inst Med Genet, Schlieren, Switzerland.
RP Reis, A (reprint author), Univ Erlangen Nurnberg, Inst Human Genet, Schwabachanlage 10, D-91054 Erlangen, Germany.
EM andre.reis@uk-erlangen.de
FU German Intellectual Disability Network (MRNET) through German Ministry
of Research and Education [01GS08160]; Swiss National Science Foundation
[SNF 320030_135669]; Research Council of Norway; Norwegian Cancer
Society; Bergen Research Foundation (BFS); Western Norway Health
Authorities
FX We are grateful to the families involved in this study for their
participation. We thank Angelika Diem and Daniela Schweitzer for
excellent technical assistance and Steffen Uebe and Arif Ekici for
assistance in NGS. This manuscript is part of a doctoral thesis of Bernt
Popp. We thank the Novocraft Technologies Company for granting a trial
license of novoalignCS. This study was supported in part by the German
Intellectual Disability Network (MRNET) through a grant from the German
Ministry of Research and Education to Andre Reis (01GS08160), by a grant
from the Swiss National Science Foundation (SNF 320030_135669) to Anita
Rauch and by the Research Council of Norway, the Norwegian Cancer
Society, Bergen Research Foundation (BFS) and the Western Norway Health
Authorities to Thomas Arnesen.
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NR 54
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
EI 1476-5438
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD MAY
PY 2015
VL 23
IS 5
BP 602
EP 609
DI 10.1038/ejhg.2014.150
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CG1JF
UT WOS:000353028200010
PM 25099252
ER
PT J
AU Vergult, S
Dheedene, A
Meurs, A
Faes, F
Isidor, B
Janssens, S
Gautier, A
Le Caignec, C
Menten, B
AF Vergult, Sarah
Dheedene, Annelies
Meurs, Alfred
Faes, Fran
Isidor, Bertrand
Janssens, Sandra
Gautier, Agnes
Le Caignec, Cedric
Menten, Bjorn
TI Genomic aberrations of the CACNA2D1 gene in three patients with epilepsy
and intellectual disability
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID DEPENDENT CALCIUM-CHANNELS; LINKED MENTAL-RETARDATION; COPY NUMBER
VARIANTS; BIPOLAR DISORDER; WIDE ASSOCIATION; MUTATION; IDENTIFICATION;
SUBUNIT; PICCOLO; PROTEIN
AB Voltage-gated calcium channels have an important role in neurotransmission. Aberrations affecting genes encoding the alpha subunit of these channels have been associated with epilepsy and neuropsychiatric disorders such as autism or schizophrenia. Here we report three patients with a genomic aberration affecting the CACNA2D1 gene encoding the alpha 2 delta subunit of these voltage-gated calcium channels. All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features. Besides these characteristics, patient 2 also presents with obesity with hyperinsulinism, which is very likely to be caused by deletion of the CD36 gene.
C1 [Vergult, Sarah; Dheedene, Annelies; Janssens, Sandra; Menten, Bjorn] Univ Ghent, Ghent Univ Hosp, Ctr Med Genet, B-9000 Ghent, Belgium.
[Meurs, Alfred] Univ Ghent, Ghent Univ Hosp, Dept Neurol, Lab Clin & Expt Neurophysiol Neurobiol & Neuropsy, B-9000 Ghent, Belgium.
[Faes, Fran] Ghent Univ Hosp, Ctr Ontwikkelingsstoornissen COS, Ghent, Belgium.
[Isidor, Bertrand; Le Caignec, Cedric] Inst Biol, Serv Genet Med, Nantes, France.
[Gautier, Agnes] CHU Nantes, Serv Pediat, F-44035 Nantes 01, France.
RP Menten, B (reprint author), Univ Ghent, Ghent Univ Hosp, Ctr Med Genet, Pintelaan 185, B-9000 Ghent, Belgium.
EM Bjorn.Menten@Ugent.be
FU Research Foundation-Flanders (FWO); Special Research Fund (BOF) from
Ghent University; Belgian State, Prime Minister's Office, Science Policy
Programming (IUAP); Wellcome Trust
FX We are indebted to the patients and their parents. We thank Willy
Lissens for the X-inactivation assay and Lies Vantomme for expert
technical assistance. Sarah Vergult was supported by a PhD fellowship of
the Research Foundation-Flanders (FWO) and is now supported by a
postdoctoral grant from the Special Research Fund (BOF) from Ghent
University. This article presents research results of the Belgian
program of Interuniversity Poles of attraction initiated by the Belgian
State, Prime Minister's Office, Science Policy Programming (IUAP). This
study makes use of data generated by the DECIPHER Consortium. A full
list of centers who contributed to the generation of the data is
available from http://decipher.sanger.ac.uk and via email from
decipher@sanger.ac.uk. Funding for the project was provided by the
Wellcome Trust.
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NR 38
TC 1
Z9 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
EI 1476-5438
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD MAY
PY 2015
VL 23
IS 5
BP 628
EP 632
DI 10.1038/ejhg.2014.141
PG 5
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CG1JF
UT WOS:000353028200014
PM 25074461
ER
PT J
AU Breeman, LD
van Lier, PAC
Wubbels, T
Verhulst, FC
van der Ende, J
Maras, A
Hopman, JAB
Tick, NT
AF Breeman, L. D.
van Lier, P. A. C.
Wubbels, T.
Verhulst, F. C.
van der Ende, J.
Maras, A.
Hopman, J. A. B.
Tick, N. T.
TI Developmental Links Between Disobedient Behavior and Social Classroom
Relationships in Boys With Psychiatric Disorders in Special Education
SO JOURNAL OF ABNORMAL CHILD PSYCHOLOGY
LA English
DT Article
DE Behavior problems; Teacher-child relationship; Peer relations; Special
education; EBD
ID TEACHER-CHILD RELATIONSHIPS; AUTISM SPECTRUM DISORDERS; PEER
RELATIONSHIPS; EXTERNALIZING BEHAVIOR; EMOTIONAL ADJUSTMENT; RECIPROCAL
RELATIONS; STUDENT RELATIONSHIP; SCHOOL ADJUSTMENT; SELF-PERCEPTIONS;
AGGRESSION
AB In mainstream education, positive relationships with teachers and peers have been found to positively influence children's behavioral development. However, high levels of classroom behavior problems may hinder the formation of such positive relationships. Therefore, findings from mainstream education cannot be generalized to special education. The present study investigated the developmental links between disobedience and positive as well as negative relationships with teachers and peers among boys in restrictive special educational settings. At three assessment waves across one school year, teacher-reports of teacher-child closeness and conflict, and peer-reports of peer acceptance, rejection and disobedience were collected among 340 boys (mean age = 10.1 years, SD = 1.58, range = 5-13) with psychiatric disorders receiving special education. Autoregressive cross-lagged models were fitted to explore the nature of these developmental links. The impact of boys' age was examined using multiple group analyses. Findings supported the importance of teacher-child conflict, but not closeness, and positive and negative peer relationships for the development of boys' disobedience, with a stronger effect of negative than positive relationships. However, teacher-child and peer relationships were not longitudinally related and the effect of boys' age was minimal. This study extends prior research by suggesting that, despite differences in educational setting and severity of behavior problems between children in mainstream and special education, reducing negative classroom interactional patterns is most important in preventing the development of problematic classroom behavior in boys with severe social-emotional and behavioral difficulties.
C1 [Breeman, L. D.; Maras, A.; Hopman, J. A. B.; Tick, N. T.] Yulius Acad, Yulius Mental Hlth, NL-3014 HH Rotterdam, Netherlands.
[Breeman, L. D.; Verhulst, F. C.; van der Ende, J.; Hopman, J. A. B.; Tick, N. T.] Erasmus MC Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, NL-3000 CB Rotterdam, Netherlands.
[van Lier, P. A. C.] Vrije Univ Amsterdam, Dept Dev Psychol, NL-1081 BT Amsterdam, Netherlands.
[Wubbels, T.] Univ Utrecht, Fac Social & Behav Sci, NL-3508 TC Utrecht, Netherlands.
RP Breeman, LD (reprint author), Yulius Acad, Yulius Mental Hlth, Mathenesserlaan 202, NL-3014 HH Rotterdam, Netherlands.
EM L.Breeman@yulius.nl
FU ZonMw, The Netherlands Organization for Health Research and Development
[15700.3011]
FX This work was supported by ZonMw, The Netherlands Organization for
Health Research and Development (project number 15700.3011) and
conducted by Yulius, the Erasmus MC-Sophia Children's Hospital, VU
University Amsterdam, Utrecht University and the CED-group. We would
like to thank all special education children and teachers for their
participation in this study.
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NR 50
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0091-0627
EI 1573-2835
J9 J ABNORM CHILD PSYCH
JI J. Abnorm. Child Psychol.
PD MAY
PY 2015
VL 43
IS 4
BP 787
EP 799
DI 10.1007/s10802-014-9935-0
PG 13
WC Psychology, Clinical; Psychology, Developmental
SC Psychology
GA CF9PV
UT WOS:000352898600015
PM 25212230
ER
PT J
AU Bone, D
Goodwin, MS
Black, MP
Lee, CC
Audhkhasi, K
Narayanan, S
AF Bone, Daniel
Goodwin, Matthew S.
Black, Matthew P.
Lee, Chi-Chun
Audhkhasi, Kartik
Narayanan, Shrikanth
TI Applying Machine Learning to Facilitate Autism Diagnostics: Pitfalls and
Promises
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism diagnostic observation schedule; Autism diagnostic interview;
Machine learning; Signal processing; Autism; Diagnosis
ID SPECTRUM DISORDERS; OBSERVATION SCHEDULE; CLASSIFICATION; INTERVIEW;
ACCURACY; BRAIN
AB Machine learning has immense potential to enhance diagnostic and intervention research in the behavioral sciences, and may be especially useful in investigations involving the highly prevalent and heterogeneous syndrome of autism spectrum disorder. However, use of machine learning in the absence of clinical domain expertise can be tenuous and lead to misinformed conclusions. To illustrate this concern, the current paper critically evaluates and attempts to reproduce results from two studies (Wall et al. in Transl Psychiatry 2(4):e100, 2012a; PloS One 7(8), 2012b) that claim to drastically reduce time to diagnose autism using machine learning. Our failure to generate comparable findings to those reported by Wall and colleagues using larger and more balanced data underscores several conceptual and methodological problems associated with these studies. We conclude with proposed best-practices when using machine learning in autism research, and highlight some especially promising areas for collaborative work at the intersection of computational and behavioral science.
C1 [Bone, Daniel; Audhkhasi, Kartik; Narayanan, Shrikanth] Univ So Calif, SAIL, Los Angeles, CA 90089 USA.
[Goodwin, Matthew S.] Northeastern Univ, Dept Hlth Sci, Boston, MA 02115 USA.
[Black, Matthew P.] Univ So Calif, Inst Informat Sci, Marina Del Rey, CA 90292 USA.
[Lee, Chi-Chun] Natl Tsing Hua Univ, Dept Elect Engn, Hsinchu 30013, Taiwan.
RP Bone, D (reprint author), Univ So Calif, SAIL, 3710 McClintock Ave, Los Angeles, CA 90089 USA.
EM dbone@usc.edu
RI ahmed, Jamila/E-8653-2015
FU NSF [1029035]; NIH [P50 DC013027, R01 DC012774]; Alfred E. Mann
Innovation in Engineering Fellowship
FX This work was supported by funds from NSF Award 1029035, "Computational
Behavioral Science: Modeling, Analysis, and Visualization of Social and
Communicative Behavior'', NIH grants P50 DC013027 and R01 DC012774, and
the Alfred E. Mann Innovation in Engineering Fellowship. The authors are
grateful to Shanping Qiu for her efforts in acquiring and preparing the
BID data for analysis.
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NR 37
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1121
EP 1136
DI 10.1007/s10803-014-2268-6
PG 16
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200001
PM 25294649
ER
PT J
AU Carlisle, GK
AF Carlisle, Gretchen K.
TI The Social Skills and Attachment to Dogs of Children with Autism
Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Dogs; Children; Attachment; Social skills
ID OWNERSHIP; THERAPY; PET
AB Children with Autism Spectrum Disorder (ASD) have deficits in social skills, and interaction with service dogs has been associated with increased social skills for children with ASD. In this telephone survey of 70 parents of children with ASD, children owning dogs had greater Mean scores for social skills, using the Social Skills Improvement System Rating Scale, while those with some type of pet (not excluding dogs) had significantly greater skills for subscale item "assertion". Parents described their children as attached to their dogs. Children owning dogs completed the Companion Animal Bonding Scale, and reported strong bonding with dogs. These findings suggest children with ASD may bond with their dogs, and pet ownership may be associated with increased social skills.
C1 Univ Missouri, Coll Vet Med, Res Ctr Human Anim Interact, Columbia, MO 65211 USA.
RP Carlisle, GK (reprint author), Univ Missouri, Coll Vet Med, Res Ctr Human Anim Interact, Clydesdale Annex 2,900 East Campus Dr, Columbia, MO 65211 USA.
EM carlislegk@missouri.edu
FU Sigma Theta Tau-Alpha Iota Chapter
FX The author acknowledges the University of Missouri Thompson Center for
Autism and Neurodevelopmental Disorders for the use of their data set in
recruitment. A grant to support this study was awarded from Sigma Theta
Tau-Alpha Iota Chapter. This paper was prepared from the author's
doctoral dissertation, acknowledging the support of her dissertation
committee members, Dr. Rebecca A. Johnson, Dr. Lawrence Ganong, Dr.
Debra Gayer and Dr. Micah Mazurek. A poster presentation of the data was
made at the Midwest Nursing Research Society conference in Chicago,
Illinois on March, 2013.
CR American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
American Veterinary Medical Association, 2012, US PET OWNERSHIP DEM
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NR 36
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1137
EP 1145
DI 10.1007/s10803-014-2267-7
PG 9
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200002
PM 25308197
ER
PT J
AU Crutchfield, SA
Mason, RA
Chambers, A
Wills, HP
Mason, BA
AF Crutchfield, Stephen A.
Mason, Rose A.
Chambers, Angela
Wills, Howard P.
Mason, Benjamin A.
TI Use of a Self-monitoring Application to Reduce Stereotypic Behavior in
Adolescents with Autism: A Preliminary Investigation of I-Connect
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Self-monitoring; Stereotypic behavior; Technology-based
application
ID MANAGEMENT TREATMENT PACKAGE; REPETITIVE BEHAVIORS; SPECTRUM DISORDER;
CHILDREN; STUDENTS; SKILLS; MODEL; REINFORCEMENT; INTERVENTIONS;
DISABILITIES
AB Many students with autism engage in a variety of complex stereotypic behaviors, impacting task completion and interfering with social opportunities. Self-monitoring is an intervention with empirical support for individuals with ASD to increase behavioral repertoires and decrease behaviors that are incompatible with successful outcomes. However, there is limited evidence for its utility for decreasing stereotypy, particularly for adolescents in school settings. This study evaluated the functional relationship between I-Connect, a technology-delivered self-monitoring program, and decreases in the level of stereotypy for two students with ASD in the school setting utilizing a withdrawal design with an embedded multiple baseline across participants. Both students demonstrated a marked decrease in stereotypy with the introduction of the self-monitoring application. Results and implications for practice and future research will be discussed.
C1 [Crutchfield, Stephen A.; Mason, Rose A.; Wills, Howard P.; Mason, Benjamin A.] Univ Kansas, Juniper Gardens Childrens Project, Kansas City, KS 66101 USA.
[Chambers, Angela] Univ Kansas, Sch Educ, Dept Special Educ, Lawrence, KS 66045 USA.
RP Crutchfield, SA (reprint author), Univ Kansas, Juniper Gardens Childrens Project, 444 Minnesota Ave, Kansas City, KS 66101 USA.
EM stephencrutchfield@ku.edu; rosemason519@gmail.com
FU U.S. Department of Education, Institute of Education Sciences
[R324B100004]; National Institute on Disability and Rehabilitation
Research [H133A130032]; Office of Special Education Programs
[H327A100082]; I-CONNECT PLUS: Enhancing Community Participation for
Adolescents and Adults with ASD Using Online Instruction, Coaching, and
Accessible Self-Management Technologies [H133A130032]
FX The authors disclosed receipt of the following financial support for the
research, and/or publication of this article: This research was
supported in part by grants from the U.S. Department of Education,
Institute of Education Sciences (R324B100004), the National Institute on
Disability and Rehabilitation Research (H133A130032), and the Office of
Special Education Programs (H327A100082). The opinions expressed in this
article are not necessarily reflective of the positions of the U.S.
Department of Education. This research was supported in part by the
Research Grant No. H133A130032, I-CONNECT PLUS: Enhancing Community
Participation for Adolescents and Adults with ASD Using Online
Instruction, Coaching, and Accessible Self-Management Technologies.
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NR 34
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1146
EP 1155
DI 10.1007/s10803-014-2272-x
PG 10
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200003
PM 25326255
ER
PT J
AU Hesselmark, E
Eriksson, JM
Westerlund, J
Bejerot, S
AF Hesselmark, Eva
Eriksson, Jonna M.
Westerlund, Joakim
Bejerot, Susanne
TI Autism Spectrum Disorders and Self-reports: Testing Validity and
Reliability Using the NEO-PI-R
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Self report; Psychometrics; Validation;
Personality tests
ID QUOTIENT AQ; DEPRESSION; INTERVIEW; ADULTS; SCALE; BIAS; PERSONALITY;
POPULATION; VALIDATION; CHILDREN
AB Although self-reported measures are frequently used to assess adults with autism spectrum disorders (ASD), the validity of self-reports is under-researched in ASD. The core symptoms of ASD may negatively affect the psychometric properties of self-reported measures. The aim of the present study was to test the validity and reliability of self-reported data using the NEO personality inventory-revised (NEO-PI-R). Forty-eight adults with ASD and 53 controls completed the NEO-PI-R and a psychiatric interview. Results indicate satisfactory internal consistency of the NEO-PI-R, a satisfactory factor structure, predicted correlations with clinician ratings in the ASD group, and predicted differences in personality between the ASD group and controls. In conclusion, the present results support the use of self-reported measures when assessing adults with ASD .
C1 [Hesselmark, Eva; Eriksson, Jonna M.; Bejerot, Susanne] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
[Hesselmark, Eva; Bejerot, Susanne] St Gorans Sjukhus, Norra Stockholm Psykiatri, S-11281 Stockholm, Sweden.
[Westerlund, Joakim] Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden.
RP Hesselmark, E (reprint author), St Gorans Sjukhus, Norra Stockholm Psykiatri, Patientvagen 2,3Tr, S-11281 Stockholm, Sweden.
EM eva.hesselmark@ki.se
FU St Goran Foundation; Swedish Society of Medicine; Thuring Foundation
FX The authors want to express their gratitude towards all participants who
agreed to sign up for the study and to Dr. Sabina Bonde who assisted in
some of the assessments. Technical support was provided by Christina
Arlinde and Ann Lindgren. This study was supported by the St Goran
Foundation, The Swedish Society of Medicine and the Thuring Foundation.
CR American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
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NR 34
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1156
EP 1166
DI 10.1007/s10803-014-2275-7
PG 11
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200004
PM 25326256
ER
PT J
AU Feldman, MA
Hendry, AM
Ward, RA
Hudson, M
Liu, XD
AF Feldman, Maurice A.
Hendry, Amanda M.
Ward, Rebecca A.
Hudson, Melissa
Liu, Xudong
TI Behavioral Development and Sociodemographics of Infants and Young
Children at Higher and Lower Risk for Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Early identification; At-risk infants; Infant siblings
ID SIBLINGS RESEARCH CONSORTIUM; SOCIOECONOMIC-STATUS; BABY SIBLINGS;
COMMUNICATION; TODDLERS; LIFE; RECURRENCE; DIAGNOSIS; HISTORY; SIGNS
AB Identification of early signs of Autism Spectrum Disorder (ASD) could lead to earlier diagnosis and intervention. This cross-sectional study used the Parent Observation of Early Markers Scale (POEMS, Feldman et al. in J Autism Dev Disord 42:13-12, 2012) to identify early signs of ASD in 69 ASD high-risk (older sibling diagnosed with ASD) and 69 sex and aged-matched ASD low-risk second-born or later infants (no family history of ASD) between 6 and 36 months of age. Family sociodemographic comparisons were also made between the risk groups. The high-risk children had significantly more elevated POEMS items than the low-risk children at 12, 18, 24, 30 and 36 months of age, even when the children subsequently diagnosed with ASD were removed from the analyses. Families of the high-risk group had older parents, lower family income and fewer mothers working out of the home than the low-risk group. These sociodemographic variables were not significantly correlated with POEMS scores. The results suggest that high-risk infants may show signs of the broader ASD phenotype as early as 12 months of age that may be unrelated to observed sociodemographic family differences.
C1 [Feldman, Maurice A.; Hendry, Amanda M.; Ward, Rebecca A.] Brock Univ, Ctr Appl Disabil Studies, St Catharines, ON L2S 3A1, Canada.
[Hudson, Melissa; Liu, Xudong] Queens Univ, Genom Lab Ongwanada, Kingston, ON K7M 8A6, Canada.
RP Feldman, MA (reprint author), Brock Univ, Ctr Appl Disabil Studies, 500 Glenridge Ave, St Catharines, ON L2S 3A1, Canada.
EM mfeldman@brocku.ca; hendry_amanda@hotmail.com; bward@brocku.ca;
melissa.hudson@queensu.ca; liux@queensu.ca
FU CIHR Interdisciplinary Health Research Team [RT-43820]; Ongwanada
FX This work was supported by CIHR Interdisciplinary Health Research Team
grant (RT-43820) to the Autism Spectrum Disorders Canadian-American
Research Consortium (ASD-CARC: www.autismresearch.ca) and funding from
Ongwanada. We thank the families, students and research assistants who
made this study possible.
CR American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
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NR 44
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1167
EP 1175
DI 10.1007/s10803-014-2277-5
PG 9
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200005
PM 25326257
ER
PT J
AU Haigh, SM
Heeger, DJ
Dinstein, I
Minshew, N
Behrmann, M
AF Haigh, Sarah M.
Heeger, David J.
Dinstein, Ilan
Minshew, Nancy
Behrmann, Marlene
TI Cortical Variability in the Sensory-Evoked Response in Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; fMRI; Sensory-evoked; Variability
ID HIGH-FUNCTIONING AUTISM; INTRAINDIVIDUAL VARIABILITY; DEVELOPMENTAL
NEUROBIOLOGY; DIAGNOSTIC INTERVIEW; SPECTRUM DISORDERS;
BINOCULAR-RIVALRY; BRAIN; CHILDREN; EPILEPSY; CONNECTIVITY
AB Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.
C1 [Haigh, Sarah M.; Behrmann, Marlene] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
[Haigh, Sarah M.; Minshew, Nancy] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
[Heeger, David J.] NYU, Dept Psychol, New York, NY 10003 USA.
[Heeger, David J.] NYU, Ctr Neural Sci, New York, NY 10003 USA.
[Dinstein, Ilan] Ben Gurion Univ Negev, Dept Psychol, IL-84105 Beer Sheva, Israel.
[Minshew, Nancy] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15213 USA.
RP Haigh, SM (reprint author), Univ Pittsburgh, Dept Psychiat, Suite 420 Oxford Bldg, Pittsburgh, PA 15213 USA.
EM haighsm@upmc.edu
RI ahmed, Jamila/E-8653-2015
FU Simons Foundation Autism Research Initiative [177638]; NIH/NICHD
[HD055748]
FX The research described here was supported by a Grant from the Simons
Foundation Autism Research Initiative (177638) to DH and MB, and a
NIH/NICHD Grant (HD055748) to NJM. The authors thank Ryan Egan for
helping with participant recruitment and fMRI testing. We also thank the
staff at the Center for Excellence in Autism Research at the University
of Pittsburgh for recruitment and assessment of participants.
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NR 57
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1176
EP 1190
DI 10.1007/s10803-014-2276-6
PG 15
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200006
PM 25326820
ER
PT J
AU van Asselt-Goverts, AE
Embregts, PJCM
Hendriks, AHC
Wegman, KM
Teunisse, JP
AF van Asselt-Goverts, A. E.
Embregts, P. J. C. M.
Hendriks, A. H. C.
Wegman, K. M.
Teunisse, J. P.
TI Do Social Networks Differ? Comparison of the Social Networks of People
with Intellectual Disabilities, People with Autism Spectrum Disorders
and Other People Living in the Community
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Intellectual disabilities; Autism; Social network; Satisfaction; Wishes
ID QUALITY-OF-LIFE; HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; SUPPORT;
ADULTS; CHILDREN; INDIVIDUALS; FRIENDSHIP; MILD; ADOLESCENTS
AB The aim of this study was to determine the similarities and differences in social network characteristics, satisfaction and wishes with respect to the social network between people with mild or borderline intellectual disabilities (ID), people with autism spectrum disorders (ASD) and a reference group. Data were gathered from 105 young adults living independently in the community. The social networks of people with ID and ASD are more restricted than those of the reference group. Compared with the other groups, people with ASD are less often satisfied with their networks. Each group has its own characteristics, issues and wishes with respect to their social network. Practical measures to enable professionals to adapt to these issues are discussed.
C1 [van Asselt-Goverts, A. E.; Embregts, P. J. C. M.; Hendriks, A. H. C.; Wegman, K. M.; Teunisse, J. P.] HAN Univ Appl Sci, Fac Hlth & Social Studies, NL-6503 GL Nijmegen, Netherlands.
[van Asselt-Goverts, A. E.; Embregts, P. J. C. M.] Tilburg Univ, Tranzo, NL-5000 LE Tilburg, Netherlands.
[Embregts, P. J. C. M.; Hendriks, A. H. C.] Dichterbij Innovat & Sci, Gennep, Netherlands.
[Embregts, P. J. C. M.] Tilburg Univ, Med & Clin Psychol, NL-5000 LE Tilburg, Netherlands.
[Hendriks, A. H. C.] Radboud Univ Nijmegen, Fac Social Sci, Sch Educ Sci, NL-6525 ED Nijmegen, Netherlands.
[Wegman, K. M.] MEE Oost Gelderland, Doetinchem, Netherlands.
[Teunisse, J. P.] Dr Leo Kannerhuis, Doorwerth, Netherlands.
RP van Asselt-Goverts, AE (reprint author), HAN Univ Appl Sci, Fac Hlth & Social Studies, POB 6960, NL-6503 GL Nijmegen, Netherlands.
EM Ida.vanAsselt@han.nl; P.J.C.M.Embregts@UvT.nl
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NR 63
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1191
EP 1203
DI 10.1007/s10803-014-2279-3
PG 13
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200007
PM 25326258
ER
PT J
AU Bouck, EC
Joshi, GS
AF Bouck, Emily C.
Joshi, Gauri S.
TI Does Curriculum Matter for Secondary Students with Autism Spectrum
Disorders: Analyzing the NLTS2
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Secondary; Education; Functional curriculum; Post-school outcomes
ID NATIONAL LONGITUDINAL TRANSITION; YOUNG-ADULTS; POSTSCHOOL OUTCOMES;
HIGH-SCHOOL; EMPLOYMENT; DISABILITIES; YOUTH; INSTRUCTION; EDUCATION;
SKILLS
AB A common presumption of secondary education is that what occurs in-school impacts students after they exit school. Previous researchers found transition-services received in school by students with autism spectrum disorder predicted their post-school success with regards to employment and independent living. This secondary analysis of the National Longitudinal Transition Study-2 sought to understand the relationship between curriculum-functional versus non-functional-and seven measures of post-school outcomes for students with autism spectrum disorder. The main results of the study include low rates of receipt of a functional curriculum, poor post-school outcomes, and the lack of relationship between curriculum and post-school outcomes for students with autism spectrum disorder.
C1 [Bouck, Emily C.] Michigan State Univ, Dept Counseling Educ Psychol & Special Educ, E Lansing, MI 48824 USA.
RP Bouck, EC (reprint author), Michigan State Univ, Dept Counseling Educ Psychol & Special Educ, 620 Farm Lane,349A Erickson Hall, E Lansing, MI 48824 USA.
EM ecb@msu.edu; kul.gauri@gmail.com
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NR 45
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1204
EP 1212
DI 10.1007/s10803-014-2281-9
PG 9
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200008
PM 25326821
ER
PT J
AU Knight, VF
Sartini, E
AF Knight, Victoria F.
Sartini, Emily
TI A Comprehensive Literature Review of Comprehension Strategies in Core
Content Areas for Students with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Evidence-based practice; Content areas;
Comprehension; Math; ELA; Science
ID SEVERE DEVELOPMENTAL-DISABILITIES; COOPERATIVE LEARNING GROUPS;
READING-COMPREHENSION; INTELLECTUAL DISABILITY; GRAPHIC ORGANIZERS;
INTEGRATION STRATEGY; QUESTION GENERATION; NORMAL-CHILDREN; TEACH
SCIENCE; YOUNG-ADULTS
AB Understanding text can increase access to educational, vocational, and recreational activities for individuals with autism spectrum disorder (ASD); however, limited research has been conducted investigating instructional practices to remediate or compensate for these comprehension challenges. The current comprehensive literature review expanded previous reviews and evaluated research quality using Reichow (Evidence-based practices and treatments for children with autism, pp 25-39. doi:10.1007/978-1-4419-6975-0_2, 2011) criteria for identifying evidence-based practices. Three questions guided the review: (a) Which approaches to comprehension instruction have been investigated for students with ASD?; (b) Have there been a sufficient number of acceptable studies using a particular strategy to qualify as an evidence-based practice for teaching comprehension across the content areas?; and (c) What can educators learn from the analysis of high quality studies? Of the 23 studies included in the review, only 13 achieved high or adequate ratings. Results of the review suggest that both response-prompting procedures (e.g., model-lead-test, time delay, system of least prompts,) and visual supports (e.g., procedural facilitators) can increase comprehension skills in content areas of ELA, math, and science. Authors conclude with a discussion of (a) research-based examples of how to use effective approaches, (b) implications for practitioners, and (c) limitations and future research.
C1 [Knight, Victoria F.] Vanderbilt Univ, Dept Special Educ, Nashville, TN 37203 USA.
[Sartini, Emily] Univ Kentucky, Lexington, KY USA.
RP Knight, VF (reprint author), Vanderbilt Univ, Dept Special Educ, GPC 228,230 Appleton Pl, Nashville, TN 37203 USA.
EM victoria.f.knight@vanderbilt.edu; emily.sartini@uky.edu
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NR 70
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1213
EP 1229
DI 10.1007/s10803-014-2280-x
PG 17
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200009
PM 25331325
ER
PT J
AU Lai, KYC
Leung, PWL
Mo, FYM
Lee, MMC
Shea, CKS
Chan, GFC
Che, KKI
Luk, ESL
Mak, ADP
Warrington, R
Skuse, D
AF Lai, Kelly Y. C.
Leung, Patrick W. L.
Mo, Flora Y. M.
Lee, Marshall M. C.
Shea, Caroline K. S.
Chan, Grace F. C.
Che, Kiti K. I.
Luk, Ernest S. L.
Mak, Arthur D. P.
Warrington, Richard
Skuse, David
TI Validation of the Developmental, Dimensional and Diagnostic Interview
(3Di) Among Chinese Children in a Child Psychiatry Clinic in Hong Kong
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; 3Di; Chinese; Validation
ID AUTISM SPECTRUM DISORDERS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
TWIN SAMPLE; POPULATION; VALIDITY; TRAITS; ADHD; HERITABILITY; SYMPTOMS
AB Autism spectrum disorder (ASD) is a disorder with high levels of co-morbidities. The Developmental, Dimensional and Diagnostic Interview (3Di) is a relatively new instrument designed to provide dimensional as well as categorical assessment of autistic behaviours among children with normal intelligence. Its sound psychometric properties and relatively short administration time make it a versatile instrument. The 3Di was translated into Chinese (Cantonese) and its applicability among 194 clinic children was examined. Results found excellent reliability and validity, and achieved a sensitivity of 95 % and specificity of 77 %. It was able to capture the diagnosis of ASD among children presenting with attention deficit hyperactivity disorder. However, although the disorder of ASD is considered universal, the use of a western instrument in a Chinese context should also take note of cultural influences that may impact on the manifestation of its symptoms.
C1 [Lai, Kelly Y. C.; Luk, Ernest S. L.; Mak, Arthur D. P.] Chinese Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China.
[Leung, Patrick W. L.] Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China.
[Mo, Flora Y. M.; Lee, Marshall M. C.; Shea, Caroline K. S.; Chan, Grace F. C.; Che, Kiti K. I.] Alice Ho Miu Ling Nethersole Hosp, Dept Psychiat, Tai Po, Hong Kong, Peoples R China.
[Warrington, Richard; Skuse, David] Inst Child Hlth, London, England.
RP Lai, KYC (reprint author), Chinese Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China.
EM kellylai@cuhk.edu.hk
RI ahmed, Jamila/E-8653-2015
CR American Psychiatric Association, 1994, DIAGNOSTIC AND STATI
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NR 23
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1230
EP 1237
DI 10.1007/s10803-014-2284-6
PG 8
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200010
PM 25326822
ER
PT J
AU Waite, J
Moss, J
Beck, SR
Richards, C
Nelson, L
Arron, K
Burbidge, C
Berg, K
Oliver, C
AF Waite, Jane
Moss, Joanna
Beck, Sarah R.
Richards, Caroline
Nelson, Lisa
Arron, Kate
Burbidge, Cheryl
Berg, Katy
Oliver, Chris
TI Repetitive Behavior in Rubinstein-Taybi Syndrome: Parallels with Autism
Spectrum Phenomenology
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Rubinstein-Taybi syndrome; Autism spectrum disorder (ASD); Repetitive
behavior; Ritualistic behavior
ID PRADER-WILLI-SYNDROME; FRAGILE-X SYNDROMES; STEREOTYPED BEHAVIORS;
DOWN-SYNDROME; CHILDREN; PREVALENCE; DISORDERS; DEFICITS; PEOPLE;
ASSOCIATIONS
AB Syndrome specific repetitive behavior profiles have been described previously. A detailed profile is absent for Rubinstein-Taybi syndrome (RTS). The Repetitive Behaviour Questionnaire and Social Communication Questionnaire were completed for children and adults with RTS (N = 87), Fragile-X (N = 196) and Down (N = 132) syndromes, and individuals reaching cut-off for autism spectrum disorder (N = 228). Total and matched group analyses were conducted. A phenotypic profile of repetitive behavior was found in RTS. The majority of behaviors in RTS were not associated with social-communication deficits or degree of disability. Repetitive behavior should be studied at a fine-grained level. A dissociation of the triad of impairments might be evident in RTS.
C1 [Waite, Jane; Moss, Joanna; Beck, Sarah R.; Richards, Caroline; Arron, Kate; Oliver, Chris] Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England.
[Moss, Joanna] UCL, Inst Cognit Neurosci, London, England.
[Nelson, Lisa] Royal Derby Hosp, Derbyshire Childrens Hosp, Dept Clin Psychol, Derby, England.
[Burbidge, Cheryl] Solihull NHS Trust, Dept Psychol, Solihull, W Midlands, England.
[Berg, Katy] Univ E London, Dept Psychol, London E15 4LZ, England.
RP Waite, J (reprint author), Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England.
EM j.e.waite@bham.ac.uk
FU Cerebra; Rubinstein Taybi Syndrome Support Group; Fragile X Society;
Down Syndrome Association; National Autistic Society
FX We are grateful to our funding body, Cerebra, and to the Rubinstein
Taybi Syndrome Support Group, Fragile X Society, Down Syndrome
Association, and National Autistic Society. We are grateful to Gemma
Warren who assisted with data collection and analysis.
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NR 58
TC 1
Z9 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1238
EP 1253
DI 10.1007/s10803-014-2283-7
PG 16
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200011
PM 25491025
ER
PT J
AU Yoder, P
Watson, LR
Lambert, W
AF Yoder, Paul
Watson, Linda R.
Lambert, Warren
TI Value-Added Predictors of Expressive and Receptive Language Growth in
Initially Nonverbal Preschoolers with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Spoken language; Useful speech; Predictors; Nonverbal;
Longitudinal
ID DIAGNOSTIC OBSERVATION SCHEDULE; CHILD-DIRECTED SPEECH; COMMUNICATIVE
DEVELOPMENT INVENTORY; YOUNG-CHILDREN; FOLLOW-UP; JOINT ATTENTION;
SOCIAL COGNITION; PHYSIOLOGICAL-RESPONSES; TYPICAL DEVELOPMENT; SYMBOLIC
PLAY
AB Eighty-seven preschoolers with autism spectrum disorders who were initially nonverbal (under 6 words in language sample and under 21 parent-reported words said) were assessed at five time points over 16 months. Statistical models that accounted for the intercorrelation among nine theoretically- and empirically-motivated predictors, as well as two background variables (i.e., cognitive impairment level, autism severity), were applied to identify value-added predictors of expressive and receptive spoken language growth and outcome. The results indicate that responding to joint attention, intentional communication, and parent linguistic responses were value-added predictors of both expressive and receptive spoken language growth. In addition, consonant inventory was a value-added predictor of expressive growth; early receptive vocabulary and autism severity were value-added predictors of receptive growth.
C1 [Yoder, Paul] Vanderbilt Univ, Special Educ, Nashville, TN 37235 USA.
[Watson, Linda R.] Univ N Carolina, Speech & Hearing Sci, Chapel Hill, NC USA.
[Lambert, Warren] Vanderbilt Univ, Vanderbilt Kennedy Ctr, Nashville, TN 37235 USA.
RP Yoder, P (reprint author), Vanderbilt Univ, Special Educ, 221 Kirkland Hall, Nashville, TN 37235 USA.
EM Paul.Yoder@vanderbilt.edu
FU National Institute for Deafness and other Communication Disorders [NIDCD
R01 DC006893]; National Institute for Child Health and Disorders (NICHD)
through the Vanderbilt Kennedy Center [P30HD15052]; Carolina Institute
for Developmental Disabilities [P30HD03110]
FX This research was funded by National Institute for Deafness and other
Communication Disorders (NIDCD R01 DC006893) and supported by the
National Institute for Child Health and Disorders (NICHD) through the
Vanderbilt Kennedy Center (P30HD15052) and the Carolina Institute for
Developmental Disabilities (P30HD03110). The content is solely the
responsibility of the authors and does not necessarily represent the
official views of the National Institutes of Health. We are very
grateful to our wonderful staff (Elizabeth Gardner, Nicole Thompson,
Paula McIntyre, Ariel Schwartz, Tricia Paulley, Kristen Fite, Maura
Tourian, Ann Firestine, Lucy Stefani, Olivia Fairchild, Amanda Haskins,
Danielle Kopkin, and Kathleen Berry), the families who trust us with
their precious children, and Tiffany Woynaroski, who edited drafts of
this manuscript.
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NR 80
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1254
EP 1270
DI 10.1007/s10803-014-2286-4
PG 17
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200012
PM 25344152
ER
PT J
AU Wiggins, LD
Reynolds, A
Rice, CE
Moody, EJ
Bernal, P
Blaskey, L
Rosenberg, SA
Lee, LC
Levy, SE
AF Wiggins, Lisa D.
Reynolds, Ann
Rice, Catherine E.
Moody, Eric J.
Bernal, Pilar
Blaskey, Lisa
Rosenberg, Steven A.
Lee, Li-Ching
Levy, Susan E.
TI Using Standardized Diagnostic Instruments to Classify Children with
Autism in the Study to Explore Early Development
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE ADI-R; ADOS; Autism; Classification; Phenotypes; Study methods
ID SOCIAL COMMUNICATION QUESTIONNAIRE; SPECTRUM DISORDERS; OBSERVATION
SCHEDULE; ADI-R; PRESCHOOL-CHILDREN; INTERVIEW; VALIDITY; ADOS; AGE
AB The Study to Explore Early Development (SEED) is a multi-site case-control study designed to explore the relationship between autism spectrum disorder (ASD) phenotypes and etiologies. The goals of this paper are to (1) describe the SEED algorithm that uses the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) to classify children with ASD, (2) examine psychometric properties of different ASD classification methods, including the SEED method that incorporates rules for resolving ADI-R and ADOS discordance, and (3) determine whether restricted interests and repetitive behaviors were noted for children who had instrument discordance resolved using ADI-R social and communication scores. Results support the utility of SEED criteria when well-defined groups of children are an important clinical or research outcome.
C1 [Wiggins, Lisa D.; Rice, Catherine E.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Reynolds, Ann; Moody, Eric J.; Rosenberg, Steven A.] Univ Colorado, Sch Med, Aurora, CO USA.
[Bernal, Pilar] Kaiser Permanente No Calif, San Jose Med Ctr, Autism Spectrum Disorders Ctr, San Jose, CA USA.
[Blaskey, Lisa; Levy, Susan E.] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Ctr Autism Res, Philadelphia, PA 19104 USA.
[Lee, Li-Ching] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
RP Wiggins, LD (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd MS E-86, Atlanta, GA 30333 USA.
EM lwiggins@cdc.gov
FU Centers for Disease Control and Prevention, Colorado Department of
Public Health [U10DD000180]; Kaiser Foundation Research Institute (CA)
[U10DD000181]; University of Pennsylvania [U10DD000182]; Johns Hopkins
University [U10DD000183]; University of North Carolina at Chapel Hill
[U10DD000184]; Michigan State University [U10DD000498]
FX We would like to thank Lisa Croen, Julie Daniels, Ellen Giarelli,
Rebecca Landa, Cordelia Robinson, Diana Schendel, Amy Sims, and Patrick
Thompson for their contributions to the development of the SEED final
classification algorithm and/or comments on previous versions of this
paper. We would also like to thank Aimee Alexander, Rebecca Cantrell,
and Laura Schieve for their assistance with data cleaning and the SEED
principal investigators, co-principal investigators, project
coordinators, project staff, and children and families who participated
in this research. This publication was supported by six cooperative
agreements from the Centers for Disease Control and Prevention:
Cooperative Agreement Number U10DD000180, Colorado Department of Public
Health; Cooperative Agreement Number U10DD000181, Kaiser Foundation
Research Institute (CA); Cooperative Agreement Number U10DD000182,
University of Pennsylvania; Cooperative Agreement Number U10DD000183,
Johns Hopkins University; Cooperative Agreement Number U10DD000184,
University of North Carolina at Chapel Hill; and Cooperative Agreement
Number U10DD000498, Michigan State University. The findings and
conclusions in this report are those of the authors and do not
necessarily represent the official position of the Centers for Disease
Control and Prevention.
CR Allen CW, 2007, J AUTISM DEV DISORD, V37, P1272, DOI 10.1007/s10803-006-0279-7
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American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 30
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1271
EP 1280
DI 10.1007/s10803-014-2287-3
PG 10
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200013
PM 25348175
ER
PT J
AU Dillen, C
Steyaert, J
Op de Beeck, HP
Boets, B
AF Dillen, Claudia
Steyaert, Jean
Op de Beeck, Hans P.
Boets, Bart
TI Visual Processing in Adolescents with Autism Spectrum Disorder: Evidence
from Embedded Figures and Configural Superiority Tests
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Embedded figures test; Configural superiority
effect; Vision
ID HIGH-FUNCTIONING AUTISM; WEAK CENTRAL COHERENCE; DISEMBEDDING
PERFORMANCE; ASPERGER-SYNDROME; COGNITIVE-STYLE; TASK-PERFORMANCE;
CHILDREN; ATTENTION; INDIVIDUALS; PERCEPTION
AB The embedded figures test has often been used to reveal weak central coherence in individuals with autism spectrum disorder (ASD). Here, we administered a more standardized automated version of the embedded figures test in combination with the configural superiority task, to investigate the effect of contextual modulation on local feature detection in 23 adolescents with ASD and 26 matched typically developing controls. On both tasks both groups performed largely similarly in terms of accuracy and reaction time, and both displayed the contextual modulation effect. This indicates that individuals with ASD are equally sensitive compared to typically developing individuals to the contextual effects of the task and that there is no evidence for a local processing bias in adolescents with ASD.
C1 [Dillen, Claudia; Steyaert, Jean; Boets, Bart] Univ Leuven KU Leuven, Dept Neurosci, Child & Adolescent Psychiat, B-3000 Leuven, Belgium.
[Dillen, Claudia; Op de Beeck, Hans P.] Katholieke Univ Leuven, Biol Psychol, Dept Psychol, B-3000 Leuven, Belgium.
[Dillen, Claudia; Steyaert, Jean; Boets, Bart] Katholieke Univ Leuven, Leuven Autism Res LAuRes, B-3000 Leuven, Belgium.
RP Boets, B (reprint author), Univ Leuven KU Leuven, Dept Neurosci, Child & Adolescent Psychiat, Herestr 49,Box 7003, B-3000 Leuven, Belgium.
EM bart.boets@ppw.kuleuven.be
FU KU Leuven Research Council [IDO/10/003]
FX The research was financed by a Grant of the KU Leuven Research Council
(IDO/10/003). Bart Boets is a postdoctoral research fellow of the
Research Foundation Flanders. We thank Lynn Herremans, Franca Geerlings
and Kaat Alaerts for assistance with data collection, and all children
and families for participating in the study.
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NR 74
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1281
EP 1290
DI 10.1007/s10803-014-2288-2
PG 10
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200014
PM 25342435
ER
PT J
AU Palmer, CJ
Paton, B
Enticott, PG
Hohwy, J
AF Palmer, Colin J.
Paton, Bryan
Enticott, Peter G.
Hohwy, Jakob
TI 'Subtypes' in the Presentation of Autistic Traits in the General Adult
Population
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autistic traits; Autism-spectrum quotient; Cluster analysis; Subgroups;
Factor analysis
ID SPECTRUM QUOTIENT AQ; MECHANICAL TURK; INDIVIDUAL-DIFFERENCES;
FAMILY-HISTORY; ILLUSION; TWIN; RELIABILITY; COMPONENTS; BEHAVIORS;
PHENOTYPE
AB The present study examined the presentation of autistic traits in a large adult population sample (n = 2,343). Cluster analysis indicated two subgroups with clearly distinguishable trait profiles. One group (n = 1,059) reported greater social difficulties and lower detail orientation, while the second group (n = 1,284) reported lesser social difficulties and greater detail orientation. We also report a three-factor solution for the autism-spectrum quotient, with two, related, social-themed factors (Sociability and Mentalising) and a third non-social factor that varied independently (Detail Orientation). These results indicate that different profiles of autistic characteristics tend to occur in the adult nonclinical population. Research into nonclinical variance in autistic features may benefit by considering social- and detail-related trait domains independently.
C1 [Palmer, Colin J.; Paton, Bryan; Hohwy, Jakob] Monash Univ, Dept Philosophy, Cognit & Philosophy Lab, Melbourne, Vic 3800, Australia.
[Paton, Bryan] Monash Univ, Monash Biomed Imaging, Melbourne, Vic 3800, Australia.
[Paton, Bryan] Monash Univ, Sch Psychol Sci, Melbourne, Vic 3800, Australia.
[Enticott, Peter G.] Deakin Univ, Sch Psychol, Cognit Neurosci Unit, Melbourne, Vic, Australia.
RP Palmer, CJ (reprint author), Monash Univ, Dept Philosophy, Cognit & Philosophy Lab, Melbourne, Vic 3800, Australia.
EM Colin.Palmer@monash.edu
FU Australian Research Council [DP1311336, FT100100322]; National Health
and Medical Research Council [546244]
FX This work was supported by an Australian Research Council Discovery
Grant (DP1311336). J.H. is supported by an Australian Research Council
Future Fellowship (FT100100322). P.E. is supported by a National Health
and Medical Research Council Clinical Research Fellowship (546244).
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American Psychiatric Association, 2013, DIAGNOSTIC AND STATI
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World Health Organization, 2004, ICD 10 INTERNATIONAL
NR 58
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1291
EP 1301
DI 10.1007/s10803-014-2289-1
PG 11
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200015
PM 25337855
ER
PT J
AU Obafemi-Ajayi, T
Miles, JH
Takahashi, TN
Qi, WC
Aldridge, K
Zhang, MQ
Xin, SQ
He, Y
Duan, Y
AF Obafemi-Ajayi, Tayo
Miles, Judith H.
Takahashi, T. Nicole
Qi, Wenchuan
Aldridge, Kristina
Zhang, Minqi
Xin, Shi-Qing
He, Ying
Duan, Ye
TI Facial Structure Analysis Separates Autism Spectrum Disorders into
Meaningful Clinical Subgroups
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Cluster analysis; Language regression; Facial phenotype;
Biomarker; Outcome indicators
ID DIAGNOSTIC OBSERVATION SCHEDULE; VALIDATION TECHNIQUES; CLUSTER
VALIDATION; REGRESSION; ALCOHOLISM; TUTORIAL; HEAD
AB Varied cluster analysis were applied to facial surface measurements from 62 prepubertal boys with essential autism to determine whether facial morphology constitutes viable biomarker for delineation of discrete Autism Spectrum Disorders (ASD) subgroups. Earlier study indicated utility of facial morphology for autism subgrouping (Aldridge et al. in Mol Autism 2(1):15, 2011). Geodesic distances between standardized facial landmarks were measured from three-dimensional stereo-photogrammetric images. Subjects were evaluated for autism-related symptoms, neurologic, cognitive, familial, and phenotypic variants. The most compact cluster is clinically characterized by severe ASD, significant cognitive impairment and language regression. This verifies utility of facially-based ASD subtypes and validates Aldridge et al.'s severe ASD subgroup, notwithstanding different techniques. It suggests that language regression may define a unique ASD subgroup with potential etiologic differences.
C1 [Obafemi-Ajayi, Tayo; Qi, Wenchuan; Duan, Ye] Univ Missouri, Dept Comp Sci, Columbia, MO 65211 USA.
[Miles, Judith H.; Takahashi, T. Nicole] Univ Missouri, Thompson Ctr Autism & Neurodev Disorders, Columbia, MO 65211 USA.
[Miles, Judith H.] Univ Missouri, Sch Med, Dept Child Hlth, Columbia, MO 65212 USA.
[Aldridge, Kristina] Univ Missouri, Sch Med, Dept Pathol & Anat Sci, Columbia, MO 65212 USA.
[Zhang, Minqi; Xin, Shi-Qing; He, Ying] Nanyang Technol Univ, Sch Comp Engn, Singapore 639798, Singapore.
RP Duan, Y (reprint author), Univ Missouri, Dept Comp Sci, 201 Engn Bldg West, Columbia, MO 65211 USA.
EM duanye@missouri.edu
RI ahmed, Jamila/E-8653-2015
CR Aldridge K, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-15
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NR 50
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1302
EP 1317
DI 10.1007/s10803-014-2290-8
PG 16
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200016
PM 25351828
ER
PT J
AU Yoshimura, S
Sato, W
Uono, S
Toichi, M
AF Yoshimura, Sayaka
Sato, Wataru
Uono, Shota
Toichi, Motomi
TI Impaired Overt Facial Mimicry in Response to Dynamic Facial Expressions
in High-Functioning Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders (ASD); Dynamic facial expression; Facial
mimicry; Reciprocal social interaction
ID RATING-SCALE; TOKYO VERSION; PERCEPTION; CHILDREN; RECOGNITION;
IMITATION; VOLUNTARY; IDENTITY; EMOTION; SYSTEM
AB Previous electromyographic studies have reported that individuals with autism spectrum disorders (ASD) exhibited atypical patterns of facial muscle activity in response to facial expression stimuli. However, whether such activity is expressed in visible facial mimicry remains unknown. To investigate this issue, we videotaped facial responses in high-functioning individuals with ASD and controls to dynamic and static facial expressions of anger and happiness. Visual coding of facial muscle activity and the subjective impression ratings showed reduced congruent responses to dynamic expressions in the ASD group. Additionally, this decline was related to social dysfunction. These results suggest that impairment in overt facial mimicry in response to others' dynamic facial expressions may underlie difficulties in reciprocal social interaction among individuals with ASD.
C1 [Yoshimura, Sayaka; Sato, Wataru; Uono, Shota] Kyoto Univ, Grad Sch Med, Dept Neurodev Psychiat Habilitat & Rehabil, Sakyo Ku, Kyoto 6068507, Japan.
[Uono, Shota; Toichi, Motomi] Org Promoting Dev Disorder Res, Sakyo Ku, Kyoto 6068392, Japan.
[Toichi, Motomi] Kyoto Univ, Grad Sch Med, Fac Human Hlth Sci, Sakyo Ku, Kyoto 6068507, Japan.
RP Yoshimura, S (reprint author), Kyoto Univ, Grad Sch Med, Dept Neurodev Psychiat Habilitat & Rehabil, Sakyo Ku, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan.
EM yoshimurasayaka@gmail.com
RI ahmed, Jamila/E-8653-2015
FU JSPS
FX The authors thank all participants for their participation in the
experiment and Ms. Minemoto and Ms. Yokoyama for their technical
assistance. This study was supported by funds from the JSPS Funding
Program for Next Generation World-Leading Researchers and the
Organization for Promoting Developmental Disorder Research.
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NR 45
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1318
EP 1328
DI 10.1007/s10803-014-2291-7
PG 11
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200017
PM 25374131
ER
PT J
AU Brennan, L
Barton, M
Chen, CM
Green, J
Fein, D
AF Brennan, Laura
Barton, Marianne
Chen, Chi-Ming
Green, James
Fein, Deborah
TI Detecting Subgroups in Children Diagnosed with Pervasive Developmental
Disorder - Not Otherwise Specified
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE PDD-NOS; Cluster analysis; DSM 5; ASD; Subgroups
ID AUTISM SPECTRUM DISORDER; MODIFIED CHECKLIST; CHILDHOOD AUTISM;
CLUSTER-ANALYSIS; AGE; VALIDATION; INTERVIEW; TODDLERS; CRITERIA; CHAT
AB Hierarchical cluster analyses were used to detect three subgroups in a sample of children with pervasive developmental disorder-not otherwise specified (PDD-NOS) evaluated at ages 2 and 4. At age 2, Cluster 1 demonstrated few autism symptoms and high cognitive scores; 60 % no longer met criteria for PDD at 4. Cluster 2 exhibited more autism symptoms and lower cognitive scores at 2; 89.5 % met criteria for ASD at 4. Cluster 3 had the lowest cognitive scores and most impaired social/communication skills at 2, but no repetitive behaviors; 60 % diagnosed with Autistic Disorder at 4. Results shed light on outcomes for different PDD-NOS types and raise questions regarding the increased importance of repetitive behaviors in DSM-5.
C1 [Brennan, Laura; Barton, Marianne; Chen, Chi-Ming; Green, James; Fein, Deborah] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA.
RP Brennan, L (reprint author), Univ Connecticut, Dept Psychol, 406 Babbidge Rd,Unit 1020, Storrs, CT 06269 USA.
EM laura.brennan@uconn.edu
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development [RO1 HD039961]
FX We are extremely grateful to all the children and families for their
participation and to the pediatrician sites, as well as Birth-to-Three
providers within Connecticut and Massachusetts, who assisted and
continue to assist our study. We would like to extend sincere thanks to
members of the Early Detection Advisory Board, especially Thyde
Dumont-Mathieu, M.D., Ho-Wen Hsu, M.D., and Mark Greenstein, M.D., for
their sage advice and support. We would also like to thank the
clinicians, graduate students, undergraduate research assistants, and
research assistants whose work has been invaluable to the study. This
study is supported by the Eunice Kennedy Shriver National Institute of
Child Health and Human Development (RO1 HD039961).
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NR 45
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1329
EP 1344
DI 10.1007/s10803-014-2295-3
PG 16
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200018
PM 25374133
ER
PT J
AU Burke, MM
Goldman, SE
AF Burke, Meghan M.
Goldman, Samantha E.
TI Identifying the Associated Factors of Mediation and Due Process in
Families of Students with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE School; Litigation; Advocacy; Family-school partnership; Internalizing
behaviors; Inclusion
ID DEVELOPMENTAL-DISABILITIES; PARENTING STRESS; CHILDREN; SCHOOL; MOTHERS;
PARTNERSHIPS; ADVOCACY; SERVICES; IMPACT
AB Compared to families of students with other types of disabilities, families of students with autism spectrum disorder (ASD) are significantly more likely to enact their procedural safeguards such as mediation and due process. However, we do not know which school, child, and parent characteristics are associated with the enactment of safeguards. For this study, 507 parents of students with ASD responded to a national web-based survey. Parents who filed for due process or mediation were more likely to advocate for their child, have poor family-school partnerships, and have greater household incomes. Parents were also more likely to utilize their safeguards if their children were older, experiencing more internalizing behaviors, and educated in segregated placements. Implications for research and practice are discussed.
C1 [Burke, Meghan M.] Univ Illinois, Dept Special Educ, Champaign, IL 61820 USA.
[Goldman, Samantha E.] Vanderbilt Univ, Dept Special Educ, Peabody Coll, Vanderbilt Kennedy Ctr, Nashville, TN 37203 USA.
RP Burke, MM (reprint author), Univ Illinois, Dept Special Educ, 288 Educ Bldg,1310 S 6th St, Champaign, IL 61820 USA.
EM meghanbm@illinois.edu; samantha.goldman@vanderbilt.edu
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NR 37
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1345
EP 1353
DI 10.1007/s10803-014-2294-4
PG 9
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200019
PM 25374132
ER
PT J
AU Meilleur, AAS
Jelenic, P
Mottron, L
AF Meilleur, Andree-Anne S.
Jelenic, Patricia
Mottron, Laurent
TI Prevalence of Clinically and Empirically Defined Talents and Strengths
in Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Perception; Savant; Talent; Block; Pitch; Expertise
ID SAVANT SYNDROME; CALENDAR CALCULATORS; PITCH DISCRIMINATION; SPECTRUM
DISORDER; ABSOLUTE PITCH; INDIVIDUALS; ABILITIES; INTELLIGENCE;
CHILDREN; PERCEPTION
AB Outstanding skills, including special isolated skills (SIS) and perceptual peaks (PP) are frequent features of autism. However, their reported prevalence varies between studies and their co-occurrence is unknown. We determined the prevalence of SIS in a large group of 254 autistic individuals and searched for PP in 46 of these autistic individuals and 46 intelligence and age-matched typically developing controls. The prevalence of SIS among autistic individuals was 62.5 % and that of PP was 58 % (13 % in controls). The prevalence of SIS increased with intelligence and age. The existence of an SIS in a particular modality was not associated with the presence of a PP in the same modality. This suggests that talents involve an experience-dependent component in addition to genetically defined alterations of perceptual encoding.
C1 [Meilleur, Andree-Anne S.; Jelenic, Patricia; Mottron, Laurent] Univ Montreal, Hop Riviere des Prairies, Ctr Excellence Pervas Dev Disorders CETEDUM, Montreal, PQ H1E 1A4, Canada.
RP Meilleur, AAS (reprint author), Univ Montreal, Hop Riviere des Prairies, Ctr Excellence Pervas Dev Disorders CETEDUM, 7070 Perras Blvd, Montreal, PQ H1E 1A4, Canada.
EM ameilleur009@gmail.com; patricia.jelenic.hrdp@ssss.gouv.qc.ca;
laurent.mottron@gmail.com
FU CIHR [171795]; Autism Speaks Foundation [2706]; Frederick Banting and
Charles Best Canada Graduate Scholarships Doctoral Award (CGS-D)
FX This work was supported by Grants from the CIHR (L.M., 171795); Autism
Speaks Foundation (L.M., 2706); and the Frederick Banting and Charles
Best Canada Graduate Scholarships Doctoral Award (CGS-D)(A-A.S.M.). We
also thank the statistician Claude Berthiaume for his advice and
availability, the HRDP autism research group for comments on the
manuscript, and our research assistant Chloe Paquin-Hodge for testing
the participants.
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NR 55
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1354
EP 1367
DI 10.1007/s10803-014-2296-2
PG 14
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200020
PM 25374134
ER
PT J
AU Hedley, D
Brewer, N
Young, R
AF Hedley, Darren
Brewer, Neil
Young, Robyn
TI The Effect of Inversion on Face Recognition in Adults with Autism
Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Eye tracking; Face inversion effect; Face
perception; Face processing; Face recognition
ID ASPERGER-SYNDROME; FUNCTIONING AUTISM; FIXATION PATTERNS; CHILDREN;
INDIVIDUALS; MEMORY; IDENTITY; INFORMATION; PERCEPTION; MECHANISMS
AB Face identity recognition has widely been shown to be impaired in individuals with autism spectrum disorders (ASD). In this study we examined the influence of inversion on face recognition in 26 adults with ASD and 33 age and IQ matched controls. Participants completed a recognition test comprising upright and inverted faces. Participants with ASD performed worse than controls on the recognition task but did not show an advantage for inverted face recognition. Both groups directed more visual attention to the eye than the mouth region and gaze patterns were not found to be associated with recognition performance. These results provide evidence of a normal effect of inversion on face recognition in adults with ASD.
C1 [Hedley, Darren; Brewer, Neil; Young, Robyn] Flinders Univ S Australia, Adelaide, SA 5001, Australia.
[Hedley, Darren] Emerson Coll, Dept Commun Sci & Disorders, Boston, MA 02116 USA.
RP Hedley, D (reprint author), Emerson Coll, Dept Commun Sci & Disorders, 120 Boylston St, Boston, MA 02116 USA.
EM DarrenHedley@gmail.com
FU Australian Research Council (ARC) [LE0882562]; ARC [DP1093210]; Flinders
University Research Grant; Flinders University Research Scholarship
(FURS)
FX This research was supported by (a) Australian Research Council (ARC)
LE0882562 to Neil Brewer, Robyn Young et al., and ARC DP1093210 to Neil
Brewer et al., (b) a Flinders University Research Grant to Robyn Young
and Neil Brewer, and (c) a Flinders University Research Scholarship
(FURS) to Darren Hedley. Portions of the research in this paper use the
Computer Vision Laboratory (CVL) Face Database, University of Ljubljana,
Slovenia (Peer 2011; Solina et al. 2003).
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NR 57
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1368
EP 1379
DI 10.1007/s10803-014-2297-1
PG 12
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200021
PM 25358250
ER
PT J
AU Schaaf, RC
Lane, AE
AF Schaaf, Roseann C.
Lane, Alison E.
TI Toward a Best-Practice Protocol for Assessment of Sensory Features in
ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Perceptual disorders; Sensory function; Sensory disorders;
Symptom assessment; Best practices
ID AUTISM SPECTRUM DISORDERS; EVENT-RELATED POTENTIALS; FUNCTIONING AUTISM;
MULTISENSORY INTEGRATION; OVER-RESPONSIVITY; ASPERGER-SYNDROME;
YOUNG-CHILDREN; DEVELOPMENTAL-DISABILITIES; EXPERIENCES QUESTIONNAIRE;
TYPICAL DEVELOPMENT
AB Sensory difficulties are a commonly occurring feature of autism spectrum disorders and are now included as one manifestation of the 'restricted, repetitive patterns of behavior, interests, or activities' diagnostic criteria of the DSM5 necessitating guidelines for comprehensive assessment of these features. To facilitate the development of such guidelines, this paper provides an overview of the literature on sensory features in autism spectrum disorder. We summarize the literature pertaining to: terminology, current assessment practices, sensory development, and the relationship of sensory features to core symptoms of autism. The paper concludes with recommendations for clinical assessment of sensory features in Autism.
C1 [Schaaf, Roseann C.] Thomas Jefferson Univ, Jefferson Sch Hlth Profess, Dept Occupat Therapy, Farber Inst Neurosci, Philadelphia, PA 19107 USA.
[Lane, Alison E.] Univ Newcastle, Sch Hlth Sci, Fac Hlth & Med, Callaghan, NSW 2308, Australia.
RP Schaaf, RC (reprint author), Thomas Jefferson Univ, Jefferson Sch Hlth Profess, Dept Occupat Therapy, Farber Inst Neurosci, 901 Walnut St,Suite 605, Philadelphia, PA 19107 USA.
EM Roseann.schaaf@jefferson.edu
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NR 138
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1380
EP 1395
DI 10.1007/s10803-014-2299-z
PG 16
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200022
PM 25374136
ER
PT J
AU Nakao, S
Scott, JM
Masterson, EE
Chi, DL
AF Nakao, Sy
Scott, JoAnna M.
Masterson, Erin E.
Chi, Donald L.
TI Non-traumatic Dental Condition-Related Emergency Department Visits and
Associated Costs for Children and Adults with Autism Spectrum Disorders
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorders; Emergency department visits; Non-traumatic
dental conditions; Dental costs
ID MEDICAID-ENROLLED CHILDREN; HEALTH-CARE EXPENDITURES; ORAL-HEALTH;
DEVELOPMENTAL-DISABILITY; WISCONSIN MEDICAID; EXPERIENCES; COMMUNITY;
DIAGNOSIS; PROGRAM; PEOPLE
AB We analyzed 2010 US National Emergency Department Sample data and ran regression models to test the hypotheses that individuals with ASD are more likely to have non-traumatic dental condition (NTDC)-related emergency department (ED) visits and to incur greater costs for these visits than those without ASD. There were nearly 2.3 million NTDC-related ED visits in 2010. Less than 1.0 % (children) and 2.1 % (adults) of all ED visits were for NTDC. There was no significant difference in NTDC-related ED visits or costs for children by ASD status. Adults with ASD had significantly lower odds of NTDC-related ED visits (OR 0.39; 95 % CI 0.29, 0.52; p < 0.001) but incurred significantly greater mean costs for NTDC-related ED visits (p < 0.006) than did adults without ASD.
C1 [Nakao, Sy; Masterson, Erin E.; Chi, Donald L.] Univ Washington, Sch Dent, Dept Oral Hlth Sci, Seattle, WA 98195 USA.
[Scott, JoAnna M.] Univ Washington, Sch Dent, Dept Pediat Dent, Seattle, WA 98195 USA.
RP Chi, DL (reprint author), Univ Washington, Sch Dent, Dept Oral Hlth Sci, Box 357475, Seattle, WA 98195 USA.
EM dchi@uw.edu
FU National Institute of Dental and Craniofacial Research (NIDCR); National
Institutes of Health (NIH) [TL1TR000422, K08DE020856]; Health Resources
and Services Administration (HRSA) [R40MC26198]
FX This research was made possible by the National Institute of Dental and
Craniofacial Research (NIDCR) and National Institutes of Health (NIH)
Grant Numbers TL1TR000422 and K08DE020856 and Health Resources and
Services Administration (HRSA) Grant Number R40MC26198.
CR Agency for Healthcare Research and Quality, 2012, INTR HCUP NAT EM DEP
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NR 58
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1396
EP 1407
DI 10.1007/s10803-014-2298-0
PG 12
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200023
PM 25374135
ER
PT J
AU Finn, L
Ramasamy, R
Dukes, C
Scott, J
AF Finn, Lisa
Ramasamy, Rangasamy
Dukes, Charles
Scott, John
TI Using WatchMinder to Increase the On-Task Behavior of Students with
Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Self-monitoring; Tactile prompting;
WatchMinder; Self-graphing; Classroom intervention
ID SELF-MANAGEMENT; CHILDREN; STRATEGIES; CLASSROOM; TEACHERS
AB This study assessed the use of WatchMinder (TM), a vibrating prompt watch, and self-graphing on the on-task behavior of students with autism spectrum disorder in an elementary special education setting. Using a multiple baseline across subjects design, results showed an immediate increase in on-task behavior when the intervention was introduced. Participants maintained high levels of on-task behavior during the follow-up phase. Implications for expanded self-monitoring treatment packages are discussed.
C1 [Finn, Lisa; Ramasamy, Rangasamy; Dukes, Charles; Scott, John] Florida Atlantic Univ, Coll Educ, Dept Except Student Educ, Boca Raton, FL 33431 USA.
RP Finn, L (reprint author), Florida Atlantic Univ, Coll Educ, Dept Except Student Educ, 777 Glades Rd, Boca Raton, FL 33431 USA.
EM lisa.finn@palmbeachschools.org
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NR 26
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1408
EP 1418
DI 10.1007/s10803-014-2300-x
PG 11
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200024
PM 25377769
ER
PT J
AU Graham, SA
Abbott, AE
Nair, A
Lincoln, AJ
Muller, RA
Goble, DJ
AF Graham, Sarah A.
Abbott, Angela E.
Nair, Aarti
Lincoln, Alan J.
Mueller, Ralph-Axel
Goble, Daniel J.
TI The Influence of Task Difficulty and Participant Age on Balance Control
in ASD
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder; Balance control; Sensorimotor integration;
Postural control; Center of pressure
ID AUTISM SPECTRUM DISORDERS; DIAGNOSTIC OBSERVATION SCHEDULE;
HIGH-FUNCTIONING AUTISM; POSTURAL CONTROL; DEVELOPMENTAL-CHANGES;
REPETITIVE BEHAVIOR; CHILDREN; ADOLESCENTS; SINGLE; STANCE
AB Impairments in sensorimotor integration are reported in Autism Spectrum Disorder (ASD). Poor control of balance in challenging balance tasks is one suggested manifestation of these impairments, and is potentially related to ASD symptom severity. Reported balance and symptom severity relationships disregard age as a potential covariate, however, despite its involvement in balance development. We tested balance control during increasingly difficult balance conditions in children with ASD and typically developing peers, and investigated relationships between balance control and diagnostic/symptom severity metrics for participants with ASD, including age as a covariate. Balance deficits in ASD were exacerbated by stance alterations, but were not related to symptom severity when age was considered. These findings support impaired balance in ASD, especially in challenging conditions, but question a link between balance and symptom severity.
C1 [Graham, Sarah A.; Goble, Daniel J.] San Diego State Univ, Coll Hlth & Human Serv, Sch Exercise & Nutr Sci, San Diego, CA 92182 USA.
[Abbott, Angela E.; Nair, Aarti; Mueller, Ralph-Axel] San Diego State Univ, Dept Psychol, Coll Sci, San Diego, CA 92182 USA.
[Lincoln, Alan J.] Alliant Int Univ, Calif Sch Profess Psychol, Dept Clin Psychol, San Diego, CA 92131 USA.
RP Goble, DJ (reprint author), San Diego State Univ, Coll Hlth & Human Serv, Sch Exercise & Nutr Sci, 5500 Campanile Dr, San Diego, CA 92182 USA.
EM dgoble@mail.sdsu.edu
CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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Whyatt CP, 2012, J AUTISM DEV DISORD, V42, P1799, DOI 10.1007/s10803-011-1421-8
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NR 45
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1419
EP 1427
DI 10.1007/s10803-014-2303-7
PG 9
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200025
PM 25381191
ER
PT J
AU Zhou, P
Crain, S
Gao, LQ
Tang, Y
Jia, MX
AF Zhou, Peng
Crain, Stephen
Gao, Liqun
Tang, Ye
Jia, Meixiang
TI The Use of Grammatical Morphemes by Mandarin-Speaking Children with High
Functioning Autism
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Grammatical morphology; Temporal processing; Event structure;
Language development
ID RECEPTIVE LANGUAGE DISORDER; EARLY ADULT LIFE; SPECTRUM DISORDERS;
FOLLOW-UP; IMPAIRMENT; TENSE; ACQUISITION; PHENOTYPES; OUTCOMES; PROSODY
AB The present study investigated the production of grammatical morphemes by Mandarin-speaking children with high functioning autism. Previous research found that a subgroup of English-speaking children with autism exhibit deficits in the use of grammatical morphemes that mark tense. In order to see whether this impairment in grammatical morphology can be generalised to children with autism from other languages, the present study examined whether or not high-functioning Mandarin-speaking children with autism also exhibit deficits in using grammatical morphemes that mark aspect. The results show that Mandarin-speaking children with autism produced grammatical morphemes significantly less often than age-matched and IQ-matched TD peers as well as MLU-matched TD peers. The implications of these findings for understanding the grammatical abilities of children with autism were discussed.
C1 [Zhou, Peng; Crain, Stephen] Macquarie Univ, ARC Ctr Excellence Cognit & Its Disorders, Dept Cognit Sci, Sydney, NSW 2109, Australia.
[Gao, Liqun; Tang, Ye] Beijing Language & Culture Univ, Beijing 100083, Peoples R China.
[Jia, Meixiang] Peking Univ Sixth Hosp, Beijing 100083, Peoples R China.
RP Zhou, P (reprint author), Macquarie Univ, ARC Ctr Excellence Cognit & Its Disorders, Dept Cognit Sci, Sydney, NSW 2109, Australia.
EM peng.zhou@mq.edu.au
RI ahmed, Jamila/E-8653-2015
FU Macquarie University; ARC Centre of Excellence in Cognition and its
Disorders [CE110001021]
FX This research was supported by a Macquarie University Research
Fellowship to the first author and also the ARC Centre of Excellence in
Cognition and its Disorders (CE110001021). The authors are grateful to
Dr. Joshua John Diehl and three anonymous reviewers for their insightful
comments and suggestions on an earlier version of the paper. The authors
would also like to thank the children and the teachers at the
Rehabilitation and Education Centre for Children with Autism affiliated
with the Peking University Sixth Hospital, Beijing, China, for their
assistance and support in running the experiments.
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NR 47
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1428
EP 1436
DI 10.1007/s10803-014-2304-6
PG 9
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200026
PM 25381192
ER
PT J
AU Harstad, EB
Fogler, J
Sideridis, G
Weas, S
Mauras, C
Barbaresi, WJ
AF Harstad, Elizabeth B.
Fogler, Jason
Sideridis, Georgios
Weas, Sarah
Mauras, Carrie
Barbaresi, William J.
TI Comparing Diagnostic Outcomes of Autism Spectrum Disorder Using
DSM-IV-TR and DSM-5 Criteria
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder (ASD); DSM-5; Confirmatory factor analysis;
Measurement invariance
ID PERVASIVE DEVELOPMENTAL DISORDER; FIT INDEXES; OBSERVATION SCHEDULE;
MODEL SELECTION; SAMPLE-SIZE; RELIABILITY; SENSITIVITY; TODDLERS;
VALIDITY; TIME
AB Controversy exists regarding the DSM-5 criteria for ASD. This study tested the psychometric properties of the DSM-5 model and determined how well it performed across different gender, IQ, and DSM-IV-TR sub-type, using clinically collected data on 227 subjects (median age = 3.95 years, majority had IQ > 70). DSM-5 was psychometrically superior to the DSM-IV-TR model (Comparative Fit Index of 0.970 vs 0.879, respectively). Measurement invariance revealed good model fit across gender and IQ. Younger children tended to meet fewer diagnostic criteria. Those with autistic disorder were more likely to meet social communication and repetitive behaviors criteria (p < .001) than those with PDD-NOS. DSM-5 is a robust model but will identify a different, albeit overlapping population of individuals compared to DSM-IV-TR.
C1 [Harstad, Elizabeth B.; Fogler, Jason; Sideridis, Georgios; Weas, Sarah; Mauras, Carrie; Barbaresi, William J.] Boston Childrens Hosp, Div Dev Med, Boston, MA 02115 USA.
[Harstad, Elizabeth B.; Fogler, Jason; Sideridis, Georgios; Mauras, Carrie; Barbaresi, William J.] Harvard Univ, Sch Med, Boston, MA USA.
RP Harstad, EB (reprint author), Boston Childrens Hosp, Div Dev Med, Boston, MA 02115 USA.
EM Elizabeth.harstad@childrens.harvard.edu
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NR 74
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1437
EP 1450
DI 10.1007/s10803-014-2306-4
PG 14
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200027
PM 25384720
ER
PT J
AU Goin-Kochel, RP
Mire, SS
Dempsey, AG
AF Goin-Kochel, Robin P.
Mire, Sarah S.
Dempsey, Allison G.
TI Emergence of Autism Spectrum Disorder in Children from Simplex Families:
Relations to Parental Perceptions of Etiology
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder; Regression; Parent perceptions; Simons Simplex
Collection
ID DEVELOPMENTAL REGRESSION; RUBELLA VACCINATION; UNITED-STATES;
RISK-FACTORS; MEASLES; MUMPS; POPULATION; CPEA; PHENOTYPE; BELIEFS
AB Current research describes a four-category scheme of Autism Spectrum Disorder (ASD) onset: early, regressive, plateau, delay + regression. To replicate prevalence of different onset types, ASD onset (per the Autism Diagnostic Interview-Revised) was examined in a large North American sample; for a subset, parents' causal beliefs were ascertained via the Revised Illness Perception Questionnaire to examine potential associations with ASD-onset types. Onset rates were similar across samples, with a slightly higher proportion of children in the subsample categorized with regression. Top-rated causes of ASD were genetics, brain structure, will of God, toxins in vaccines, and environmental pollution. Parents reporting regression more often believed that toxins in vaccines caused ASD. Influences on treatment selection and broader public-health ramifications are discussed.
C1 [Goin-Kochel, Robin P.] Baylor Coll Med, Houston, TX 77030 USA.
[Goin-Kochel, Robin P.] Texas Childrens Hosp, Autism Ctr, Houston, TX 77054 USA.
[Mire, Sarah S.] Univ Houston, Houston, TX USA.
[Dempsey, Allison G.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
RP Goin-Kochel, RP (reprint author), Texas Childrens Hosp, Autism Ctr, 8080 N Stadium Dr,Suite 180, Houston, TX 77054 USA.
EM kochel@bcm.edu
FU Simons Foundation [SFARIto SSC-15]
FX This work was supported by a grant from the Simons Foundation (SFARIto
SSC-15 to R. Goin-Kochel and A. Beaudet). We are grateful to all of the
families at the participating Simons Simplex Collection (SSC) sites, as
well as the principal investigators (A. Beaudet, R. Bernier, J.
Constantino, E. Cook, E. Fombonne, D. Geschwind, R. Goin-Kochel, E.
Hanson, D. Grice, A. Klin, D. Ledbetter, C. Lord, C. Martin, D. Martin,
R. Maxim, J. Miles, O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C.
Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren, E.
Wijsman). We appreciate obtaining access to phenotypic data on SFARI
Base. Approved researchers can obtain the SSC population dataset
described in this study (https://ordering.base.sfari.org/similar to
browse_collection/archive[sfari_collection_v14_1]/ui:view()) by applying
at https://base.sfari.org.
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Zhang Y, 2012, J CHILD NEUROL, V27, P975, DOI 10.1177/0883073811430163
NR 43
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1451
EP 1463
DI 10.1007/s10803-014-2310-8
PG 13
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200028
PM 25398603
ER
PT J
AU Goldman, S
DeNigris, D
AF Goldman, Sylvie
DeNigris, Danielle
TI Parents' Strategies to Elicit Autobiographical Memories in Autism
Spectrum Disorders, Developmental Language Disorders and Typically
Developing Children
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Parent-child conversation; Past event; Recall
ID HIGH-FUNCTIONING CHILDREN; VERBAL RESPONSIVENESS; MULTIPLE-INCIDENCE;
JOINT ATTENTION; YOUNG-CHILDREN; SELF; COMMUNICATION; BEHAVIORS;
TODDLERS; DEFICITS
AB Conversations about the past support the development of autobiographical memory. Parents' strategies to elicit child's participation and recall during past event conversations were compared across three school-age diagnostic groups: autism spectrum disorder (ASD, n = 11), developmental language disorders (n = 11) and typically developing (TD, n = 11). We focused on the prevalence of directives versus enrichment of events. Groups did not differ in number of events, length, and total turns. However, parents of children with ASD produced more direct questions, corrections, and unrelated turns than parents of TD children. Results highlight how parents adjusted their conversational style to their child's communication difficulties to maximize interactions and how these strategies may affect the development of personal conversations.
C1 [Goldman, Sylvie] Albert Einstein Coll Med, Rose F Kennedy Intellectual & Dev Disabil Res Ctr, Saul R Korey Dept Neurol, Dept Pediat, Bronx, NY 10461 USA.
[DeNigris, Danielle] CUNY, Grad Ctr, Dept Psychol, New York, NY 10016 USA.
RP Goldman, S (reprint author), Columbia Univ, Med Ctr, GH Sergievski Ctr, 622 West 168th St,PH18-331, New York, NY 10032 USA.
EM sg3253@cumc.columbia.edu
FU Einstein/Montefiore Autism Center; Eunice Kennedy Shriver National
Institute of Child Health and Human Development of the National
Institutes of Health (NIH) [P30HD071593]
FX Sylvie Goldman was supported by the Einstein/Montefiore Autism Center
and by a grant from the Eunice Kennedy Shriver National Institute of
Child Health and Human Development of the National Institutes of Health
(NIH) under Award Number P30HD071593. Portions of this manuscript were
presented at The International Meeting for Autism Research (IMFAR) in
Atlanta, Georgia 2014. We thank the children and their parents for their
participation. We are thankful to Dr Katherine Nelson for her insightful
comments on a previous version of the manuscript and for her
unconditional support.
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NR 55
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1464
EP 1473
DI 10.1007/s10803-014-2271-y
PG 10
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200029
PM 25312278
ER
PT J
AU Reese, RM
Jamison, TR
Braun, M
Wendland, M
Black, W
Hadorn, M
Nelson, EL
Prather, C
AF Reese, R. Matthew
Jamison, T. Rene
Braun, Matt
Wendland, Maura
Black, William
Hadorn, Megan
Nelson, Eve-Lynn
Prather, Carole
TI Brief Report: Use of Interactive Television in Identifying Autism in
Young Children: Methodology and Preliminary Data
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Telemedicine; Underserved populations; Assessment; Evaluation
ID HEALTH-CARE NEEDS; SPECTRUM DISORDER; TELEMEDICINE; DIAGNOSIS
AB Children living in rural and underserved areas experience decreased access to health care services and are often diagnosed with autism at a later age compared to those living in urban or suburban areas. This study examines the utility and validity of an ASD assessment protocol conducted via video conferencing (VC). Participants (n = 17) included families with young children (2.5-6 years) requesting an evaluation for ASD in an interdisciplinary clinic. We randomly assigned families to complete an additional evaluation either in-person or via VC prior to their clinic appointment and compared diagnostic impressions to their interdisciplinary clinic evaluation. Results demonstrate excellent inter-rater agreement on diagnoses between clinicians in the VC setting and the interdisciplinary team, which suggests VC may be a viable method to increase access to autism diagnostic services, and ultimately early intervention, for families in rural and underserved areas.
C1 [Reese, R. Matthew; Jamison, T. Rene; Braun, Matt; Wendland, Maura; Hadorn, Megan; Prather, Carole] Univ Kansas, Med Ctr, Ctr Child Hlth & Dev, Kansas City, KS 66160 USA.
[Black, William] Univ Missouri, Kansas City, KS USA.
[Nelson, Eve-Lynn] Univ Kansas, Med Ctr, Ctr TeleMed & TeleHlth, Kansas City, KS 66160 USA.
RP Jamison, TR (reprint author), Univ Kansas, Med Ctr, Ctr Child Hlth & Dev, 3901 Rainbow Blvd,Mailstop 4003, Kansas City, KS 66160 USA.
EM rjamison@kumc.edu
FU National Institute Of Mental Health of the National Institutes of Health
[R21MH098133]; Department of Defense Autism Concept Grant
[W81XWH-08-1-0233]
FX Research reported in this publication was supported by the National
Institute Of Mental Health of the National Institutes of Health under
Award Number R21MH098133. The content is solely the responsibility of
the authors and does not necessarily represent the official views of the
National Institutes of Health. This study is based on pilot data from a
previous study (Reese et al. 2013) supported by a Department of Defense
Autism Concept Grant (Number W81XWH-08-1-0233).
CR American Academy of Pediatrics, 2006, AAP AUT SCREEN GUID
American Academy of Pediatrics, 2006, DEV SURV SCREEN
Barretro A, 2006, J APPL BEHAV ANAL, V39, P333, DOI 10.1901/jaba.2006.173-04
Carbone PS, 2010, AM FAM PHYSICIAN, V81, P453
Centers for Disease Control and Prevention, 2014, SURVEILLANCE SUMMARI, V63, P1
Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370
Farmer JE, 2001, CLIN PEDIATR, V40, P93, DOI 10.1177/000992280104000205
Filipek PA, 2000, NEUROLOGY, V55, P468
Heitzman-Powell LS, 2014, FOCUS AUTISM DEV DIS, V29, P23, DOI 10.1177/1088357613504992
Interagency Autism Coordinating Committee (IACC), 2013, INT AUT COORD COMM S
Lauritsen MB, 2014, J AUTISM DEV DISORD, V44, P394, DOI 10.1007/s10803-013-1875-y
Lord C., 2012, AUTISM DIAGNOSTIC 1
Mandell DS, 2007, J AUTISM DEV DISORD, V37, P1795, DOI 10.1007/s10803-006-0314-8
Marcin JP, 2004, PEDIATRICS, V113, P1, DOI 10.1542/peds.113.1.1
Nesbitt T. S., 2006, ENHANCING MENTAL HLT
Newschaffer CJ, 2005, PEDIATRICS, V115, pE277, DOI 10.1542/peds.2004-1958
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Rutter M., 2003, AUTISM DIAGNOSTIC II
NR 18
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1474
EP 1482
DI 10.1007/s10803-014-2269-5
PG 9
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200030
PM 25331323
ER
PT J
AU Faughn, C
Marrus, N
Shuman, J
Ross, SR
Constantino, JN
Pruett, JR
Povinelli, DJ
AF Faughn, Carley
Marrus, Natasha
Shuman, Jeremy
Ross, Stephen R.
Constantino, John N.
Pruett, John R., Jr.
Povinelli, Daniel J.
TI Brief Report: Chimpanzee Social Responsiveness Scale (CSRS) Detects
Individual Variation in Social Responsiveness for Captive Chimpanzees
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Comparative cognition; Autism; Social Responsiveness Scale; Chimpanzee;
Nonhuman primate
ID PAN-TROGLODYTES PERSONALITY; RECIPROCITY; COGNITION; INTERCHANGE;
DOMINANCE; MIND
AB Comparative studies of social responsiveness, a core impairment in autism spectrum disorder (ASD), will enhance our understanding of typical and atypical social behavior. We previously reported a quantitative, cross-species (human-chimpanzee) social responsiveness measure, which included the development of the Chimpanzee Social Responsiveness Scale (CSRS). Here, we augment our prior CSRS sample with 25 zoo chimpanzees at three sites: combined N = 54. The CSRS demonstrated strong interrater reliability, and low-ranked chimpanzees, on average, displayed higher CSRS scores. The CSRS continues to discriminate variation in chimpanzee social responsiveness, and the association of higher scores with lower chimpanzee social standing has implications for the relationship between autistic traits and human social status. Continued comparative investigations of social responsiveness will enhance our understanding of underlying impairments in ASD, improve early diagnosis, and inform future therapies.
C1 [Faughn, Carley] Univ Louisiana Lafayette, Inst Cognit Sci, Lafayette, LA 70504 USA.
[Marrus, Natasha; Pruett, John R., Jr.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
[Shuman, Jeremy] Indiana State Univ, Clin Psychol, Terre Haute, IN 47809 USA.
[Ross, Stephen R.] Lincoln Pk Zoo, Lester E Fisher Ctr Study & Conservat Apes, Chicago, IL USA.
[Constantino, John N.] Washington Univ, Sch Med, Dept Psychiat, Child Div, St Louis, MO 63110 USA.
[Constantino, John N.] Washington Univ, Sch Med, Pediat, St Louis, MO 63110 USA.
[Povinelli, Daniel J.] Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA.
RP Pruett, JR (reprint author), Washington Univ, Sch Med, Dept Psychiat, 660 So Euclid Ave,Campus Box 8134, St Louis, MO 63110 USA.
EM carley.faughn@gmail.com; pruettj@psychiatry.wustl.edu
FU James S. McDonnell Centennial Fellowship; [K12 EY016336]
FX We would like to thank the Species Survival Plan for Chimpanzees, the
Lester E. Fisher Center for the Study and Conservation of Apes and the
animal care staff at the Lincoln Park Zoo, the North Carolina Zoo, the
Knoxville Zoo, the Primate Rescue Center, and the St. Louis Zoo. This
research was supported by K12 EY016336 (JRP) and a James S. McDonnell
Centennial Fellowship (DJP).
CR Arnold K, 2003, BEHAVIOUR, V140, P519, DOI 10.1163/156853903322127968
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NR 34
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1483
EP 1488
DI 10.1007/s10803-014-2273-9
PG 6
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200031
PM 25312279
ER
PT J
AU Shumer, DE
Roberts, AL
Reisner, SL
Lyall, K
Austin, SB
AF Shumer, Daniel E.
Roberts, Andrea L.
Reisner, Sari L.
Lyall, Kristen
Austin, S. Bryn
TI Brief Report: Autistic Traits in Mothers and Children Associated with
Child's Gender Nonconformity
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism spectrum disorder; Gender; Gender identity; Gender nonconformity;
Transgender
ID IDENTITY DISORDER; SOCIAL RESPONSIVENESS; POSTTRAUMATIC STRESS; SPECTRUM
DISORDERS; ASPERGER-SYNDROME; RISK; ANDROGENS; VARIANCE; ABUSE
AB We examined relationships between autistic traits in children, mothers, and fathers and gender nonconformity (GNC) in children using data from the Nurses' Health Study II and the Growing Up Today Study 1. Autistic traits of mothers, fathers and children were measured using the Social Responsiveness Scale (SRS). GNC in children was measured using questions from the Recalled Childhood Gender Identity/Gender Role Questionnaire. In multivariable analyses increase in child's SRS score was associated with increased odds (OR 1.35; p = 0.03) of being in a higher GNC category. Increase in maternal SRS score was also associated with increased odds (OR 1.46; p = 0.005) of the child being in a higher GNC category. Paternal SRS scores were not related to child's GNC category.
C1 [Shumer, Daniel E.] Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA.
[Roberts, Andrea L.; Austin, S. Bryn] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
[Reisner, Sari L.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Reisner, Sari L.] Fenway Inst, Boston, MA USA.
[Lyall, Kristen] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
[Lyall, Kristen] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
[Austin, S. Bryn] Boston Childrens Hosp, Div Adolescent Young Adult Med, Boston, MA 02115 USA.
[Austin, S. Bryn] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA.
[Austin, S. Bryn] Harvard Univ, Sch Med, Boston, MA USA.
RP Austin, SB (reprint author), Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, 665 Huntington Ave, Boston, MA 02115 USA.
EM Daniel.shumer@childrens.harvard.edu; bryn.austin@childrens.harvard.edu
FU National Institute of Health (NIH) [CA50385, T32MH073124-08,
P60AR047782, HD057368, R01ES017-04]; Autism Speaks Grants [1788, 2210];
United States Department of Defense [W81XWH-08-1-0499]; United States
Army Medical Research and Material Command (USAMRMC) [A-14917]; Eunice
Kennedy Shriver National Institute of Child Health and Human Development
[1T32HD075727-01]; Leadership Education in Adolescent Health Project,
Maternal and Child Health Bureau [HRSA 6T71-MC00009]
FX The Nurses' Health Study II and the Growing Up Today Study are ongoing
studies conducted at the Channing Division of Network Medicine,
Department of Medicine, Brigham and Women's Hospital, Harvard School of
Public Health, and Harvard Medical School. The work reported in this
manuscript was supported by the National Institute of Health (NIH)
Grants CA50385, T32MH073124-08, P60AR047782, HD057368, and R01ES017-04,
Autism Speaks Grants 1788 and 2210, the United States Department of
Defense Grant W81XWH-08-1-0499, and the United States Army Medical
Research and Material Command (USAMRMC) Grant A-14917. D. E. Shumer is
supported by the Eunice Kennedy Shriver National Institute of Child
Health and Human Development, 1T32HD075727-01. S.B. Austin is supported
by the Leadership Education in Adolescent Health Project, Maternal and
Child Health Bureau, HRSA 6T71-MC00009.
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Landen M, 1997, EUR CHILD ADOLES PSY, V6, P170
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Mukaddes NM, 2002, CHILD CARE HLTH DEV, V28, P529, DOI 10.1046/j.1365-2214.2002.00301.x
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Shechner Tomer, 2010, Isr J Psychiatry Relat Sci, V47, P132
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NR 40
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1489
EP 1494
DI 10.1007/s10803-014-2292-6
PG 6
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200032
PM 25358249
ER
PT J
AU Shiozawa, BJ
AF Shiozawa, Brian J.
TI It's About Time for Autism Reform Legislation in Utah
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Insurance; Legislation; Reform; Applied behavioral analysis
AB On 3 April 2014, Governor Gary Herbert signed into law a health insurance reform bill that requires private insurers to cover autism therapy. Specifically, SB57 requires state-regulated health plans to cover applied behavior analysis (ABA) therapy. While early diagnosis and intervention can reduce the long-term cost of autism, families are finding themselves bankrupt in order to pay for ABA therapy. Currently, 37 states, and the District of Columbia have enacted insurance reform laws. Ensuring that children with autism receive proper therapy is a serious public health issue. Utah was right to pass reform legislation because it properly benefits and safeguards the interests of affected children in promoting their well-being and participation in society.
C1 Mendoza Soldier Family Care Clin, William Beaumont Army Med Ctr, Ft Bliss, TX 79916 USA.
RP Shiozawa, BJ (reprint author), Mendoza Soldier Family Care Clin, William Beaumont Army Med Ctr, 11335 SSG Sims St, Ft Bliss, TX 79916 USA.
EM brian.shiozawa@gmail.com
CR Autism Society, 2014, BUDG CRIS ADV NEWS
Autism Speaks, 2014, 35 UT EN AUT INS REF
Autism Speaks, 2014, SALT LAK MAY PROP UT
Autism Speaks, 2014, NEW RES FINDS ANN CO
Autism Speaks, 2014, STAT IN MAP ADV NEWS
May H., 2014, SALT LAKE TRIBUNE
Missouri Department of Insurance Financial Institutions and Professional Registration, 2014, INS COV AUT TREAT AP
Stewart K., 2014, SALT LAKE TRIBUNE
NR 8
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD MAY
PY 2015
VL 45
IS 5
BP 1495
EP 1496
DI 10.1007/s10803-014-2302-8
PG 2
WC Psychology, Developmental
SC Psychology
GA CG6JS
UT WOS:000353407200033
PM 25395093
ER
PT J
AU Luo, SY
Huang, W
Xia, QP
Du, Q
Wu, LQ
Duan, RH
AF Luo, Shiyu
Huang, Wen
Xia, Qiuping
Du, Qian
Wu, Lingqian
Duan, Ranhui
TI Mutational Analyses of the FMR1 Gene in Chinese Pediatric Population of
Fragile X Suspects: Low Tolerance for Point Mutation
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
DE FMR1 mutation; deletion; Chinese pediatrics
AB CGG repeat expansion is the most common cause of fragile X syndrome. Numerous efforts have been made to identify novel mutations in patients with intellectual disability, developmental delay, and/or autism. To evaluate the mutational spectrum in the at-risk Chinese population, 60 pediatric patients presenting fragile X traits but normal-sized CGG repeats were sequenced for all 17 exons and regulatory regions in FMR1. A c.879A>C mutation, reported to alter a neighboring splicing, was detected in a severely retarded male and his normal mother. However, the exon junction appears unaffected. A 237-kb deletion covering the entire FMR1 was identified to cause moderate intellectual disability and marked hyperactivity in an 8-year-old boy. The 5 and 3 breakpoints were buried in the surrounding long interspersed and short interspersed elements, respectively. In general, missense mutations do not commonly cause fragile X syndrome, whereas deletions should be considered with caution in patient referrals presenting with developmental delay and/or ordinary retardation.
C1 [Luo, Shiyu; Huang, Wen; Xia, Qiuping; Du, Qian; Wu, Lingqian; Duan, Ranhui] Cent S Univ, State Key Lab Med Genet, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China.
RP Duan, RH (reprint author), Cent S Univ, State Key Lab Med Genet, Changsha 410078, Hunan, Peoples R China.
EM wulingqian@sklmg.edu.cn; duanranhui@sklmg.edu.cn
RI ahmed, Jamila/E-8653-2015
FU National Key Basic Research Program of China [2012CB944600]; National
Natural Science Foundation of China [81071028, 81172513]; National Key
Technology R&D Program of China [2012BAI09B05]; Program for New Century
Excellent Talents in University [NCET-10-0832]
FX The authors disclosed receipt of the following financial support for the
research, authorship, and/or publication of this article: This work was
funded in part by grants from the National Key Basic Research Program of
China (grant 2012CB944600), National Natural Science Foundation of China
(grant 81071028, 81172513), National Key Technology R&D Program of China
(grant 2012BAI09B05), Program for New Century Excellent Talents in
University (grant NCET-10-0832).
CR Coffee B, 2008, AM J MED GENET A, V146A, P1358, DOI 10.1002/ajmg.a.32261
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NR 10
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0883-0738
EI 1708-8283
J9 J CHILD NEUROL
JI J. Child Neurol.
PD MAY
PY 2015
VL 30
IS 6
BP 803
EP 806
DI 10.1177/0883073814538508
PG 4
WC Clinical Neurology; Pediatrics
SC Neurosciences & Neurology; Pediatrics
GA CG8SZ
UT WOS:000353584100023
PM 24963073
ER
PT J
AU Rosqvist, HB
Brownlow, C
O'Dell, L
AF Rosqvist, Hanna Bertilsdotter
Brownlow, Charlotte
O'Dell, Lindsay
TI 'An Association for All'-Notions of the Meaning of Autistic
Self-Advocacy Politics within a Parent-Dominated Autistic Movement
SO JOURNAL OF COMMUNITY & APPLIED SOCIAL PSYCHOLOGY
LA English
DT Article
DE self-advocacy; autism; identity; Asperger syndrome; parents
ID DISABILITY
AB In this paper, we seek to explore the tensions between advocacy and self advocacy autistic movements in a Swedish context with a special focus on the meanings that enable the production of particular understandings of autism and the autistic subject. Drawing on articles written for the Swedish advocacy magazine Empowerment written for and by people with autism, the discourse analysis explores two competing discourses: a reformist and a radical. The reformist discourse underlines a goal of (political) representation expressed in Empowerment. It may be understood as an important part of producing a legitimate autistic political subject-positioned as a full member, with a full membership-within a parent-dominated autistic advocacy movement. The reformist discourse can be viewed as a result of a negotiation, where full membership is conditioned on the parents' terms and granted on specific terms. These include working together (neuro-inclusively), advocacy based on interest rather than identity/position as a specific target/member group, agreement upon a definition of autism as a disability (a deficit) a person has rather than an identity. In relation to this, an alternative legitimate autistic subject is produced through invoking the counter-hegemonic radical discourse. Such a narrative produces the Asperger' or Aspie'. Here, the full membership' refers to a sense of identification with sense of belonging to and being at home with other people with autism. It contains a certain amount of autistic solidarity within the group of adults with autism. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Rosqvist, Hanna Bertilsdotter] Umea Univ, Dept Social Work, S-90187 Umea, Sweden.
[Brownlow, Charlotte] Univ So Queensland, Sch Psychol Counselling & Community, Toowoomba, Qld 4350, Australia.
[O'Dell, Lindsay] Open Univ, Fac Hlth & Social Care, Milton Keynes MK7 6AA, Bucks, England.
RP Rosqvist, HB (reprint author), Umea Univ, Dept Social Work, S-90187 Umea, Sweden.
EM Hanna.Bertilsdotter.Rosqvist@umu.se
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NR 24
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1052-9284
EI 1099-1298
J9 J COMMUNITY APPL SOC
JI J. Community Appl. Soc. Psychol.
PD MAY-JUN
PY 2015
VL 25
IS 3
BP 219
EP 231
DI 10.1002/casp.2210
PG 13
WC Psychology, Social
SC Psychology
GA CG4EM
UT WOS:000353236200003
ER
PT J
AU Marshall, J
Hill, RJ
Ware, RS
Ziviani, J
Dodrill, P
AF Marshall, Jeanne
Hill, Rebecca J.
Ware, Robert S.
Ziviani, Jenny
Dodrill, Pamela
TI Multidisciplinary Intervention for Childhood Feeding Difficulties
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE autism spectrum disorders; feeding difficulties; intervention;
nutrition; weight
ID AUTISM SPECTRUM DISORDERS; FAILURE-TO-THRIVE; CHILDREN; GROWTH;
BEHAVIORS; OUTCOMES; INFANCY
AB Objective: The aim of the study was to determine whether operant conditioning (OC) or systematic desensitization (SysD) intervention resulted in more improvements in dietary variety/intake, and more reductions in difficult mealtime behaviors.
Methods: Children 2 to 6 years with autism spectrum disorder or with a nonmedically complex history were recruited. Feeding difficulties were confirmed based on clinical assessment. Participants were randomized to receive 10 OC or SysD sessions (parents could opt for intervention once per week, or intensively within a week). Immersive parent education was delivered across both arms. A 3-month review was provided to measure outcomes postintervention.
Results: In total, 68 participants (87%) completed the study. There were no significant differences in outcome measures between the OC and SysD intervention groups from baseline to 3-month review. When the data were combined across both groups, however, significant improvements in primary outcome measures were observed (P < 0.05). Although not statistically significant, it was considered clinically significant that participants in the OC arm demonstrated more increases in dietary variety (mean difference 3.3 foods, 95% confidence interval -0.1 to 6.8, P = 0.06) compared with the SysD arm. There were limited differences in response observed between the autism spectrum disorder and nonmedically complex history groups, and the intensive and weekly arms.
Conclusions: Favorable results were observed regardless of intervention, intensity, or etiological group. Results suggest that, when delivered to a protocol by experienced therapists and coupled with parent education, these 2 intervention approaches are effective. Further research is required in exploring these interventions across other subgroups, and examining outcomes for longer periods.
C1 [Marshall, Jeanne; Hill, Rebecca J.] Univ Queensland, Childrens Nutr Res Ctr, Royal Childrens Hosp, Brisbane, Qld, Australia.
[Ware, Robert S.] Univ Queensland, Royal Childrens Hosp, Child Hlth Res Ctr, Brisbane, Qld, Australia.
[Ziviani, Jenny] Univ Queensland, Royal Childrens Hosp, Sch Hlth & Rehabil Sci, Brisbane, Qld, Australia.
[Dodrill, Pamela] Univ Queensland, Royal Childrens Hosp, Childrens Hlth Queensland, Brisbane, Qld, Australia.
RP Marshall, J (reprint author), Lady Cilento Childrens Hosp, Speech Pathol Dept, Level 7,501 Stanley St, South Brisbane, Qld 4101, Australia.
EM j.marshall@uq.edu.au
RI Ware, Robert/B-2024-2014
OI Ware, Robert/0000-0002-6129-6736
FU Queensland Children's Medical Research Institute, University of
Queensland; Children's Health Queensland
FX The study was supported by Queensland Children's Medical Research
Institute, University of Queensland, and Children's Health Queensland.
CR Abidin RR, 1995, PARENTING STRESS IND
Barker DJP, 1999, ARCH DIS CHILD, V80, P305
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NR 31
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD MAY
PY 2015
VL 60
IS 5
BP 680
EP 687
DI 10.1097/MPG.0000000000000669
PG 8
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA CG6LA
UT WOS:000353410900028
PM 25534777
ER
PT J
AU Stewart, SB
Greene, DJ
Lessov-Schlaggar, CN
Church, JA
Schlaggar, BL
AF Stewart, Stephanie B.
Greene, Deanna J.
Lessov-Schlaggar, Christina N.
Church, Jessica A.
Schlaggar, Bradley L.
TI Clinical Correlates of Parenting Stress in Children with Tourette
Syndrome and in Typically Developing Children
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID PREVALENCE; DISORDER; MOTHERS; AUTISM; SCALE
AB Objective To determine the impact of tic severity in children with Tourette syndrome on parenting stress and the impact of comorbid attention-deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) symptomatology on parenting stress in both children with Tourette syndrome and typically developing children.
Study design Children with diagnosed Tourette syndrome (n = 74) and tic-free typically developing control subjects (n = 48) were enrolled in a cross-sectional study.
Results Parenting stress was greater in the group with Tourette syndrome than the typically developing group. Increased levels of parenting stress were related to increased ADHD symptomatology in both children with Tourette syndrome and typically developing children. Symptomatology of OCD was correlated with parenting stress in Tourette syndrome. Parenting stress was independent of tic severity in patients with Tourette syndrome.
Conclusions For parents of children with Tourette syndrome, parenting stress appears to be related to the child's ADHD and OCD comorbidity and not to the severity of the child's tic. Subthreshold ADHD symptomatology also appears to be related to parenting stress in parents of typically developing children. These findings demonstrate that ADHD symptomatology impacts parental stress both in children with and without a chronic tic disorder.
C1 [Stewart, Stephanie B.; Schlaggar, Bradley L.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
[Stewart, Stephanie B.; Greene, Deanna J.; Lessov-Schlaggar, Christina N.; Schlaggar, Bradley L.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
[Greene, Deanna J.; Schlaggar, Bradley L.] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA.
[Church, Jessica A.] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA.
[Schlaggar, Bradley L.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
[Schlaggar, Bradley L.] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA.
RP Stewart, SB (reprint author), Washington Univ, Sch Med, Dept Neurol, 4525 Scott Ave, St Louis, MO 63110 USA.
EM stewarts@npg.wustl.edu
FU National Institute on Drug Abuse (NIDA) [T32 DA007261]; National
Institute of Neurological Disorders and Stroke (NINDS) [F32 NS065649];
National Institute of Mental Health (NIMH) [R21 Q3MH091512];
Intellectual and Developmental Disabilities Research Center at
Washington University National Institute of Health (NIH)/National
Institute of Child Health and Human Development (NICHD) [P30 HD062171]
FX Funded by National Institute on Drug Abuse (NIDA) (T32 DA007261 [to
S.S.]), National Institute of Neurological Disorders and Stroke (NINDS)
(F32 NS065649 [to J.C.]), National Institute of Mental Health (NIMH)
(R21 Q3MH091512 [to B.S.]), and the Intellectual and Developmental
Disabilities Research Center at Washington University (National
Institute of Health (NIH)/National Institute of Child Health and Human
Development (NICHD) (P30 HD062171). The authors declare no conflicts of
interest.
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NR 23
TC 0
Z9 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD MAY
PY 2015
VL 166
IS 5
BP 1297
EP U539
DI 10.1016/j.jpeds.2015.01.041
PG 9
WC Pediatrics
SC Pediatrics
GA CG6DW
UT WOS:000353387100039
PM 25769235
ER
PT J
AU Van Battum, EY
Brignani, S
Pasterkamp, RJ
AF Van Battum, Eljo Y.
Brignani, Sara
Pasterkamp, R. Jeroen
TI Axon guidance proteins in neurological disorders
SO LANCET NEUROLOGY
LA English
DT Review
ID AMYOTROPHIC-LATERAL-SCLEROSIS; CONGENITAL MIRROR MOVEMENTS;
TEMPORAL-LOBE EPILEPSY; AUTISM SPECTRUM DISORDERS; ONSET
ALZHEIMERS-DISEASE; CENTRAL-NERVOUS-SYSTEM; HORIZONTAL GAZE PALSY;
MOTOR-NEURON DISEASE; PARKINSON-DISEASE; SEMAPHORIN 3A
AB Many neurological disorders are characterised by structural changes in neuronal connections, ranging from presymptomatic synaptic changes to the loss or rewiring of entire axon bundles. The molecular mechanisms that underlie this perturbed connectivity are poorly understood, but recent studies suggest a role for axon guidance proteins. Axon guidance proteins guide growing axons during development and control structural plasticity of synaptic connections in adults. Changes in expression or function of these proteins might induce pathological changes in neural circuits that predispose to, or cause, neurological diseases. For some neurological disorders, such as midline crossing disorders, investigators have identified causative mutations in genes for axon guidance. However, for most other disorders, evidence is correlative and further studies are needed to confirm the pathological role of defects in proteins for axon guidance. Importantly, further insight into how dysregulation of axon guidance proteins causes disease will help the development of therapeutic strategies for neurological disorders.
C1 [Van Battum, Eljo Y.; Brignani, Sara; Pasterkamp, R. Jeroen] Univ Med Ctr Utrecht, Dept Translat Neurosci, Brain Ctr Rudolf Magnus, NL-3584 CG Utrecht, Netherlands.
RP Pasterkamp, RJ (reprint author), Univ Med Ctr Utrecht, Dept Translat Neurosci, Brain Ctr Rudolf Magnus, NL-3584 CG Utrecht, Netherlands.
EM r.j.pasterkamp@umcutrecht.nl
FU Dutch Epilepsy Fund; Prinses Beatrix Fund; International Parkinson Fund;
European Union [289581]; Collaborative project Epi-miRNA
[FP7-HEALTH-2013-INNOVATION-1]; CTMM, the Center for Translational
Molecular Medicine, project EMINENCE [01C-204]
FX Our work was supported by the Dutch Epilepsy Fund, the Prinses Beatrix
Fund, the International Parkinson Fund, the People Programme (Marie
Curie Actions) of the European Union's Seventh Framework Programme (FP7)
2007-2013 under REA grant agreement number 289581 (NPlast), and the
FP7-HEALTH-2013-INNOVATION-1 Collaborative project Epi-miRNA. Our work
was partly performed within the framework of CTMM (to RJP), the Center
for Translational Molecular Medicine, project EMINENCE (01C-204).
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NR 114
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1474-4422
EI 1474-4465
J9 LANCET NEUROL
JI Lancet Neurol.
PD MAY
PY 2015
VL 14
IS 5
BP 532
EP 546
DI 10.1016/S1474-4422(14)70257-1
PG 15
WC Clinical Neurology
SC Neurosciences & Neurology
GA CG6SY
UT WOS:000353433900013
ER
PT J
AU Laxman, DJ
McBride, BA
Jeans, LM
Dyer, WJ
Santos, RM
Kern, JL
Sugimura, N
Curtiss, SL
Weglarz-Ward, JM
AF Laxman, Daniel J.
McBride, Brent A.
Jeans, Laurie M.
Dyer, W. Justin
Santos, Rosa M.
Kern, Justin L.
Sugimura, Niwako
Curtiss, Sarah L.
Weglarz-Ward, Jenna M.
TI Father Involvement and Maternal Depressive Symptoms in Families of
Children with Disabilities or Delays
SO MATERNAL AND CHILD HEALTH JOURNAL
LA English
DT Article
DE Depression; Disability related studies; Family and mental illness;
Families with disabled members; Fathers level and quality of child-care
involvement
ID DEVELOPMENTAL DELAY; YOUNG-CHILDREN; PRESCHOOL-CHILDREN; PARENTING
STRESS; MOTHERS; AUTISM; ASSOCIATIONS; METAANALYSIS; PERCEPTIONS;
PREDICTORS
AB This study examined the longitudinal association between fathers' early involvement in routine caregiving, literacy, play, and responsive caregiving activities at 9 months and maternal depressive symptoms at 4 years. Data for 3,550 children and their biological parents were drawn from the Early Childhood Longitudinal Study-Birth Cohort data set. Analyses in a structural equation modeling framework examined whether the association between father involvement and maternal depressive symptoms differed for families of children with autism spectrum disorder (ASD) and for families of children with other disabilities or delays from families of children who were typically developing. Results indicated that father literacy and responsive caregiving involvement were associated with lower levels of depressive symptoms for mothers of children with ASD. These findings indicate that greater father involvement may benefit families of children with ASD and highlight the need to support and encourage service providers to work with fathers.
C1 [Laxman, Daniel J.] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
[McBride, Brent A.; Santos, Rosa M.; Kern, Justin L.; Sugimura, Niwako; Curtiss, Sarah L.; Weglarz-Ward, Jenna M.] Univ Illinois, Urbana, IL 61801 USA.
[Jeans, Laurie M.] St Ambrose Univ, Davenport, IA USA.
[Dyer, W. Justin] Brigham Young Univ, Provo, UT 84602 USA.
RP Laxman, DJ (reprint author), Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA.
EM dlaxman@Waisman.Wisc.edu
FU Institute for Education Sciences of the U.S. Department of Education
[R324A120174]; Eunice Kennedy Shriver National Institute of Child Health
& Human Development of the National Institutes of Health [T32HD007489,
P30HD003352]
FX This research was supported by a grant from the Institute for Education
Sciences of the U.S. Department of Education to B. McBride, R. Santos,
S. Hong, and W. J. Dyer (R324A120174). This research was also supported
in part by the Eunice Kennedy Shriver National Institute of Child Health
& Human Development of the National Institutes of Health under Award
Numbers T32HD007489 and P30HD003352. The content is solely the
responsibility of the authors and does not necessarily represent the
official views of the Institute for Education Sciences or the National
Institutes of Health.
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NR 32
TC 0
Z9 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1092-7875
EI 1573-6628
J9 MATERN CHILD HLTH J
JI Matern. Child Health J.
PD MAY
PY 2015
VL 19
IS 5
BP 1078
EP 1086
DI 10.1007/s10995-014-1608-7
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA CG0SM
UT WOS:000352978500016
PM 25326111
ER
PT J
AU Fujiwara, H
Yassin, W
Murai, T
AF Fujiwara, Hironobu
Yassin, Walid
Murai, Toshiya
TI Neuroimaging studies of social cognition in schizophrenia
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Review
DE magnetic resonance imaging; multimodal imaging; quality of life;
schizophrenia; social cognition
ID EMOTIONAL FACIAL EXPRESSIONS; VOXEL-BASED MORPHOMETRY; WHITE-MATTER
INTEGRITY; FRONTAL-LOBE PATHOLOGY; HUMAN AMYGDALA; GRAY-MATTER; NORMAL
ADULTS; MIND; RECOGNITION; AUTISM
AB Impaired social cognition is considered a core contributor to unfavorable psychosocial functioning in schizophrenia. Rather than being a unitary process, social cognition is a collection of multifaceted processes that recruit multiple brain structures, thus structural and functional neuroimaging techniques are ideal methodologies for revealing the underlying pathophysiology of impaired social cognition. Many neuroimaging studies have suggested that in addition to white-matter deficits, schizophrenia is associated with decreased gray-matter volume in multiple brain areas, especially fronto-temporal and limbic regions. However, few schizophrenia studies have examined associations between brain abnormalities and social cognitive disabilities. During the last decade, we have investigated structural brain abnormalities in schizophrenia using high-resolution magnetic resonance imaging, and our findings have been confirmed by us and others. By assessing different types of social cognitive abilities, structural abnormalities in multiple brain regions have been found to be associated with disabilities in social cognition, such as recognition of facial emotion, theory of mind, and empathy. These structural deficits have also been associated with alexithymia and quality of life in ways that are closely related to the social cognitive disabilities found in schizophrenia. Here, we overview a series of neuroimaging studies from our laboratory that exemplify current research into this topic, and discuss how it can be further tackled using recent advances in neuroimaging technology.
C1 [Fujiwara, Hironobu; Yassin, Walid; Murai, Toshiya] Kyoto Univ, Grad Sch Med, Dept Psychiat, Kyoto 6068507, Japan.
[Fujiwara, Hironobu] Kyoto Univ Hosp, Integrated Clin Educ Ctr, Kyoto 606, Japan.
RP Murai, T (reprint author), Kyoto Univ, Grad Sch Med, Dept Psychiat, Sakyo Ku, Shogoinkawahara Cho 54, Kyoto 6068507, Japan.
EM murai@kuhp.kyoto-u.ac.jp
RI ahmed, Jamila/E-8653-2015
FU Japan Society for the Promotion of Science [22220003, 23390290,
23118004]; Ministry of Education, Culture, Sports, Science and
Technology, Japan
FX The authors declare no conflict of interest. This study was funded by a
Grant-in-Aid for Scientific Research (S) (22220003), a Grant-in-Aid for
Scientific Research (B) (23390290), and a Grant-in-Aid for Scientific
Research on Innovative Areas (23118004), from the Japan Society for the
Promotion of Science and the Ministry of Education, Culture, Sports,
Science and Technology, Japan. H.F. wrote the first draft of the
manuscript, critically reviewed it, and approved the final manuscript as
submitted. W.Y. managed the literature search, contributed to the
writing of the manuscript, critically reviewed it, and approved the
final manuscript as submitted. T.M. supervised, reviewed, and edited the
manuscript, and approved it as submitted.
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NR 50
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD MAY
PY 2015
VL 69
IS 5
SI SI
BP 259
EP 267
DI 10.1111/pcn.12258
PG 9
WC Clinical Neurology; Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CG8FY
UT WOS:000353543900003
PM 25418865
ER
PT J
AU Liu, K
Bearman, PS
AF Liu, Kayuet
Bearman, Peter S.
TI Focal Points, Endogenous Processes, and Exogenous Shocks in the Autism
Epidemic
SO SOCIOLOGICAL METHODS & RESEARCH
LA English
DT Article
DE autism; simulation; social interactions; environmental risks; diffusion
ID INCREASED PREVALENCE; CALIFORNIA; RISK; ASSOCIATION; THIMEROSAL;
INFLUENZA; VACCINES; DISEASE
AB Autism prevalence has increased rapidly in the United States during the past two decades. We have previously shown that the diffusion of information about autism through spatially proximate social relations has contributed significantly to the epidemic. This study expands on this finding by identifying the focal points for interaction that drive the proximity effect on subsequent diagnoses. We then consider how diffusion dynamics through interaction at critical focal points, in tandem with exogenous shocks, could have shaped the spatial dynamics of autism in California. We achieve these goals through an empirically calibrated simulation model of the whole population of 3- to 9-year-olds in California. We show that in the absence of interaction at these fociprincipally malls and schoolswe would not observe an autism epidemic. We also explore the idea that epigenetic changes affecting one generation in the distal past could shape the precise spatial patterns we observe among the next generation.
C1 [Liu, Kayuet] Univ Calif Los Angeles, Dept Sociol, Los Angeles, CA 90024 USA.
[Bearman, Peter S.] Columbia Univ, Paul F Lazarsfeld Ctr Social Sci, New York, NY 10027 USA.
RP Bearman, PS (reprint author), Columbia Univ, 701b Knox Hall,622 W 122nd St, New York, NY 10027 USA.
EM psb17@columbia.edu
FU National Institutes of Health (NIH) Director's Pioneer Award program,
part of the NIH Roadmap for Medical Research [1 DP1 OD003635-01]
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This
research is supported by the National Institutes of Health (NIH)
Director's Pioneer Award program, part of the NIH Roadmap for Medical
Research (Grant 1 DP1 OD003635-01).
CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346
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Windham G. C., 2010, INT M AUT RES PHIL P
NR 25
TC 0
Z9 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0049-1241
EI 1552-8294
J9 SOCIOL METHOD RES
JI Sociol. Methods. Res.
PD MAY
PY 2015
VL 44
IS 2
SI SI
BP 272
EP 305
DI 10.1177/0049124112460369
PG 34
WC Social Sciences, Mathematical Methods; Sociology
SC Mathematical Methods In Social Sciences; Sociology
GA CG3UD
UT WOS:000353204200004
ER
PT J
AU Tamouza, R
Bennabi, M
Delorme, R
Fortier, C
Marzais, F
Gaman, A
Charron, D
Bourgeron, T
Leboyer, M
Tamouza, R
AF Tamouza, Ryad
Bennabi, Meriem
Delorme, Richard
Fortier, Catherine
Marzais, Francois
Gaman, Alexandru
Charron, Dominique
Bourgeron, Thomas
Leboyer, Marion
Tamouza, Ryad
TI HLA-CLASS II GENETIC SIGNATURES IN AUTISM SPECTRUM DISORDERS
SO TISSUE ANTIGENS
LA English
DT Meeting Abstract
CT European-Federation-for-Immunogenetics Conference
CY APR 26-29, 2015
CL Geneva, SWITZERLAND
SP European Federat Immunogenet
C1 [Tamouza, Ryad; Tamouza, Ryad] Jean Dausset Lab, Paris, France.
[Tamouza, Ryad; Bennabi, Meriem; Tamouza, Ryad] INSERM, UMRS 1160, Paris, France.
[Delorme, Richard] Hop Robert Debre, DHU Protect Serv Psychiat Enfant & Adolescent, F-75019 Paris, France.
[Fortier, Catherine; Marzais, Francois; Charron, Dominique] St Louis Hosp, Jean Dausset Lab, Paris, France.
[Gaman, Alexandru] FondaMental Fdn, Creteil, France.
[Bourgeron, Thomas] Inst Pasteur, Dept Genet Humaine & Fonct Cognit, Paris, France.
[Leboyer, Marion] Hop Henri Mondor, INSERM, U955, F-94010 Creteil, France.
EM tamouza.ryad@gmail.com
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-2815
EI 1399-0039
J9 TISSUE ANTIGENS
JI Tissue Antigens
PD MAY
PY 2015
VL 85
IS 5
MA P20
BP 337
EP 337
PG 1
WC Cell Biology; Immunology; Pathology
SC Cell Biology; Immunology; Pathology
GA CF9SN
UT WOS:000352907000097
ER
PT J
AU Tamouza, R
Bennabi, M
Delorme, R
Fortier, C
Marzais, F
Gaman, A
Charron, D
Bourgeron, T
Leboyer, M
Tamouza, R
AF Tamouza, Ryad
Bennabi, Meriem
Delorme, Richard
Fortier, Catherine
Marzais, Francois
Gaman, Alexandru
Charron, Dominique
Bourgeron, Thomas
Leboyer, Marion
Tamouza, Ryad
TI CLEC7A (DECTIN-1) POLYMOPHISMS IN AUTISM SPECTRUM DISORDERS: GENETIC
RISK FACTORS AND GENETIC DISEASE SPECIFIERS
SO TISSUE ANTIGENS
LA English
DT Meeting Abstract
CT European-Federation-for-Immunogenetics Conference
CY APR 26-29, 2015
CL Geneva, SWITZERLAND
SP European Federat Immunogenet
C1 [Tamouza, Ryad; Tamouza, Ryad] Jean Dausset Lab, Paris, France.
[Bennabi, Meriem] INSERM, UMRS 1160, Paris, France.
[Bennabi, Meriem] St Louis Hosp, INSERM, U1160, Paris, France.
[Delorme, Richard] Hop Robert Debre, Dept Pediat Psychiat, F-75019 Paris, France.
[Fortier, Catherine; Marzais, Francois; Charron, Dominique] St Louis Hosp, Jean Dausset Lab, Paris, France.
[Gaman, Alexandru] FondaMental Fdn, Creteil, France.
[Bourgeron, Thomas] Pasteur Inst Paris, Dept Genet & Cognit Funct, Paris, France.
[Leboyer, Marion] Hop Henri Mondor, Dept Psychiat, F-94010 Creteil, France.
EM tamouza.ryad@gmail.com
NR 0
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-2815
EI 1399-0039
J9 TISSUE ANTIGENS
JI Tissue Antigens
PD MAY
PY 2015
VL 85
IS 5
MA P39
BP 344
EP 344
PG 1
WC Cell Biology; Immunology; Pathology
SC Cell Biology; Immunology; Pathology
GA CF9SN
UT WOS:000352907000116
ER
PT J
AU Choi, US
Kim, SY
Sim, HJ
Lee, SY
Park, SY
Jeong, JS
Seol, KI
Yoon, HW
Jhung, K
Park, JI
Cheon, KA
AF Choi, Uk-Su
Kim, Sun-Young
Sim, Hyeon Jeong
Lee, Seo-Young
Park, Sung-Yeon
Jeong, Joon-Sup
Seol, Kyeong In
Yoon, Hyo-Woon
Jhung, Kyungun
Park, Jee-In
Cheon, Keun-Ah
TI Abnormal Brain Activity in Social Reward Learning in Children with
Autism Spectrum Disorder: An fMRI Study
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE ASDs; social reward leaning; fMRI
ID DIAGNOSTIC INTERVIEW; INFORMATION; CORTEX
AB Purpose: We aimed to determine whether Autism Spectrum Disorder (ASD) would show neural abnormality of the social reward system using functional MRI (fMRI). Materials and Methods: 27 ASDs and 12 typically developing controls (TDCs) participated in this study. The social reward task was developed, and all participants performed the task during fMRI scanning. Results: ASDs and TDCs with a social reward learning effect were selected on the basis of behavior data. We found significant differences in brain activation between the ASDs and TDCs showing a social reward learning effect. Compared with the TDCs, the ASDs showed reduced activity in the right dorsolateral prefrontal cortex, right orbitofrontal cortex, right parietal lobe, and occipital lobe; however, they showed increased activity in the right parahippocampal gyrus and superior temporal gyms. Conclusion: These findings suggest that there might be neural abnormality of the social reward learning system of ASDs. Although this study has several potential limitations, it presents novel findings in the different neural mechanisms of social reward learning in children with ASD and a possible useful biomarker of high-functioning ASDs.
C1 [Choi, Uk-Su; Park, Sung-Yeon; Jeong, Joon-Sup] Gachon Univ Med & Sci, Neurosci Res Inst, Inchon, South Korea.
[Kim, Sun-Young; Sim, Hyeon Jeong; Lee, Seo-Young; Seol, Kyeong In; Park, Jee-In; Cheon, Keun-Ah] Yonsei Univ, Div Child & Adolescent Psychiat, Dept Psychiat, Coll Med, Seoul 120752, South Korea.
[Kim, Sun-Young; Sim, Hyeon Jeong; Lee, Seo-Young; Seol, Kyeong In; Park, Jee-In; Cheon, Keun-Ah] Yonsei Univ, Inst Behav Sci Med, Yonsei Autism Lab, Coll Med, Seoul 120752, South Korea.
[Yoon, Hyo-Woon] Daegu Cyber Univ, Dept Art Therapy, Daegu, South Korea.
[Jhung, Kyungun] Konyang Univ, Dept Psychiat, Coll Med, Taejon, South Korea.
RP Cheon, KA (reprint author), Yonsei Univ, Div Child & Adolescent Psychiat, Dept Psychiat, Coll Med, 50-1 Yonsei Ro, Seoul 120752, South Korea.
EM kacheon@yuhs.ac
RI ahmed, Jamila/E-8653-2015
FU Korean Health Technology R&D Project, Ministry of Health & Welfare,
Republic of Korea [HI12C0021 (A120029), HI12C0245 (A120296)]; Yonsei
University College of Medicine [6-2010-0139]
FX This work was supported by a research grant from the Korean Health
Technology R&D Project, Ministry of Health & Welfare, Republic of Korea
[Grant number: HI12C0021 (A120029), HI12C0245 (A120296)] and by a
faculty research grant from Yonsei University College of Medicine for
2010 (6-2010-0139).
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NR 26
TC 0
Z9 0
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD MAY 1
PY 2015
VL 56
IS 3
BP 705
EP 711
DI 10.3349/ymj.2015.56.3.705
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CG8AO
UT WOS:000353529200015
PM 25837176
ER
PT J
AU Kaur, K
Simon, AF
Chauhan, V
Chauhan, A
AF Kaur, Kulbir
Simon, Anne F.
Chauhan, Ved
Chauhan, Abha
TI Effect of bisphenol A on Drosophila melanogaster behavior - A new model
for the studies on neurodevelopmental disorders
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Autism; Bisphenol A; Drosophila melanogaster; Grooming; Locomotion;
Social interaction
ID AUTISM SPECTRUM DISORDERS; MONOGENIC HERITABLE AUTISM; EARLY PRENATAL
EXPOSURE; SOCIAL-INTERACTION; OPEN-FIELD; MENTAL-RETARDATION;
DEVELOPMENTAL TOXICITY; ENVIRONMENTAL-FACTORS; LOCOMOTOR-ACTIVITY;
MATING-BEHAVIOR
AB Developmental disorders such as autism and attention deficit hyperactivity disorder (ADHD) appear to have a complex etiology implicating both genetic and environmental factors. Bisphenol A (BPA), a widely used chemical in the plastic containers and in the linings of food and beverage cans, has been suggested to play a possible causative role in some developmental disorders. Here, we report behavioral modifications in Drosophila melanogaster following early exposure to BPA, which may suggest BPA as an environmental risk factor for the behavioral impairments that are the basis of diagnosis of autism and ADHD. In an open field assay with perinatally BPA-exposed and vehicle-treated control Drosophila, different parameters of locomotion (distance traveled, walking speed, spatial movement, mobility, turn angle, angular velocity and meander) were analyzed using the ethovision software. We also examined the repetitive and social interaction behaviors in these flies. In an open field assay, we identified disturbances in the locomotion patterns of BPA-exposed Drosophila that may relate to the decision-making and the motivational state of the animal. An increase in repetitive behavior was observed as an increase in the grooming behavior of Drosophila following BPA exposure. Furthermore, we also observed abnormal social interaction by the BPA-exposed flies in a social setting. These results demonstrate the effect of the environmentally prevalent risk agent BPA on the behavior of Drosophila, and suggest the practicability and the ease of using Drosophila as a model in the studies of neurobehavioral developmental disorders. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Kaur, Kulbir; Chauhan, Ved; Chauhan, Abha] New York State Inst Basic Res Dev Disabil, Dept Neurochem, Staten Isl, NY 10314 USA.
[Kaur, Kulbir] CUNY, Grad Ctr, Biol Neurosci Grad Program, New York, NY 10016 USA.
[Kaur, Kulbir] Ctr Dev Neurosci & Dev Disabil, Staten Isl, NY 10314 USA.
[Simon, Anne F.] Univ Western Ontario, Fac Sci, Dept Biol, London, ON N6A 3K7, Canada.
RP Chauhan, A (reprint author), New York State Inst Basic Res Dev Disabil, Dept Neurochem, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM abha.chauhan@opwdd.ny.gov
FU New York State Office for People with Developmental Disabilities; Autism
Research Institute; CUNY - Graduate Center/CSI-CDNDD Program
FX We thank Dr. Ira Cohen for providing Noldus EthoVision-XT system and his
helpful critiques on the manuscript. This work was supported in part by
funds from the New York State Office for People with Developmental
Disabilities, Autism Research Institute and CUNY - Graduate
Center/CSI-CDNDD Program.
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NR 97
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD MAY 1
PY 2015
VL 284
BP 77
EP 84
DI 10.1016/j.bbr.2015.02.001
PG 8
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CF6NB
UT WOS:000352672300010
PM 25660202
ER
PT J
AU Weisman, O
Agerbo, E
Carter, CS
Harris, JC
Uldbjerg, N
Henriksen, TB
Thygesen, M
Mortensen, PB
Leckman, JF
Dalsgaard, S
AF Weisman, Omri
Agerbo, Esben
Carter, C. Sue
Harris, James C.
Uldbjerg, Niels
Henriksen, Tine B.
Thygesen, Malene
Mortensen, Preben B.
Leckman, James F.
Dalsgaard, Soren
TI Oxytocin-augmented labor and risk for autism in males
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Pitocin; Autism; Labor; Augmentation; Gender bias; Birth cohort
ID SPECTRUM DISORDERS; PITOCIN INDUCTION; WOMEN; GENE; ASSOCIATION;
VASOPRESSIN; INFERENCE; CHILDREN; HUMANS; OXTR
AB The use of synthetic oxytocin (OT) to induce and/or augment labor and delivery is on the rise. Maternal exposure to OT during birth may have adverse effects on the infant's development, including increased risk for autism. Yet, studies that test this biologically plausible association and whether it is modified by sex are limited and show inconsistent findings. To this end, we conducted an epidemiological analysis, including all singleton live births in Denmark between 2000 and 2009 (N=557,040), with a follow-up through 2012. A total of 2110 children in this cohort were subsequently diagnosed with autistic disorder according to the ICD-10-DCR. Augmentation of labor with OT was modestly associated with an increased risk for autism in males (HR 1.13; 95% CI, 1.00-1.26; P=0.04), but not in females (0.99; 0.77-1.27; P=0.95). Among males exposed to OT augmentation, 560 were subsequently diagnosed with autistic disorder, and among those not exposed, 1177 met criteria for autism (incidence rate 103.2 and 81.4 per 100,000 person-years, respectively). Our findings suggest a modest association between OT-augmented labor and risk for autism in males. However, given the known benefits of using synthetic OT during labor and delivery caution is warranted when interpreting the findings. Future studies should also investigate dose-dependent effect of OT on infant's development. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Weisman, Omri; Leckman, James F.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA.
[Agerbo, Esben; Thygesen, Malene; Mortensen, Preben B.; Dalsgaard, Soren] Aarhus Univ, Sch Business & Social Sci, Dept Econ & Business, Natl Ctr Register Based Res, Aarhus, Denmark.
[Agerbo, Esben; Mortensen, Preben B.; Dalsgaard, Soren] iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark.
[Agerbo, Esben; Mortensen, Preben B.; Dalsgaard, Soren] iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Copenhagen, Denmark.
[Agerbo, Esben; Thygesen, Malene] Aarhus Univ, Dept Econ & Business, CIRRAU Ctr Integrated Register Based Res, Aarhus, Denmark.
[Carter, C. Sue] Indiana Univ, Kinsey Inst, Bloomington, IN USA.
[Harris, James C.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Harris, James C.] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD USA.
[Uldbjerg, Niels] Aarhus Univ, Dept Clin Med Obstet & Gynecol, Aarhus, Denmark.
[Henriksen, Tine B.] Aarhus Univ Hosp, Dept Pediat, Perinatal Epidemiol Res Unit, Skejby, Denmark.
[Dalsgaard, Soren] Hosp Telemark, Dept Child & Adolescent Psychiat, Kragero, Norway.
RP Weisman, O (reprint author), Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA.
EM omri.weisman@yale.edu
RI Agerbo, Esben /A-2645-2012
OI Agerbo, Esben /0000-0002-2849-524X
FU Lundbeck Foundation; Centre For Integrated Register-Based Research at
Aarhus University (CIRRAU); Fulbright; Rothschild Fellowships
FX SD and EA are grateful for the financial support provided by The
Lundbeck Foundation, and the Centre For Integrated Register-Based
Research at Aarhus University (CIRRAU). The work conducted by OW is
supported by the Fulbright and the Rothschild Fellowships.
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NR 51
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD MAY 1
PY 2015
VL 284
BP 207
EP 212
DI 10.1016/j.bbr.2015.02.028
PG 6
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CF6NB
UT WOS:000352672300025
PM 25707712
ER
PT J
AU Dichter, GS
Miller, S
Hannah, E
Kovac, M
Damiano, C
Sabatino, A
Turner-Brown, L
Sasson, N
Campbell, A
Benning, S
AF Dichter, Gabriel S.
Miller, Stephanie
Hannah, Eleanor
Kovac, Megan
Damiano, Cara
Sabatino, Antionette
Turner-Brown, Lauren
Sasson, Noah
Campbell, Alana
Benning, Stephen
TI The Late Positive Potential indicates Heightened Emotion Responses to
Restricted Interests in Youth with Autism Spectrum Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism spectrum disorder; event related potential; restricted interests;
late positive potential
C1 [Dichter, Gabriel S.] Univ N Carolina, Psychiat, Chapel Hill, NC USA.
[Miller, Stephanie; Hannah, Eleanor; Kovac, Megan; Damiano, Cara; Sabatino, Antionette; Turner-Brown, Lauren; Campbell, Alana] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC USA.
[Sasson, Noah] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA.
[Benning, Stephen] Univ Nevada, Psychol, Las Vegas, NV 89154 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 533
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207501127
ER
PT J
AU Fecteau, S
AF Fecteau, Shirley
TI Modulation of Emotional Processing with rTMS on Autism Spectrum
Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE noninvasive brain stimulation; autism spectrum disorders; emotion
C1 [Fecteau, Shirley] Univ Laval, Med, Quebec City, PQ, Canada.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 477
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207501071
ER
PT J
AU Holsboer-Trachsler, E
AF Holsboer-Trachsler, Edith
TI Aerobic Exercise and Skill Training Improved Objective Sleep and Motor
Skills in Children Suffering from Autism Spectrum Disorder (ASD) - A
Pilot Study
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Aerobic exercise; sleep; motor skills; ASD; children
C1 [Holsboer-Trachsler, Edith] Univ Basel, Ctr Affect Stress & Sleep Disorders, Psychiat Clin, Basel, Switzerland.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 553
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207501147
ER
PT J
AU Ou, JJ
Shen, YD
Zhao, JP
AF Ou, Jianjun
Shen, Yidong
Zhao, Jingping
TI The Association Study of Prenatal and Perinatal Stress and Autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE autism; prenatal; perinatal; stress
C1 [Ou, Jianjun; Shen, Yidong; Zhao, Jingping] Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
RI ahmed, Jamila/E-8653-2015
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 591
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207501185
ER
PT J
AU Siegel, SJ
AF Siegel, Steven J.
TI Altered Gamma Band Power Association with Treatment Resistant Deficits
in Cognitive Function in Schizophrenia and NMDA Receptor Animal Model
Thereof
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE mouse; EEG; Schiizophrenia; Autism; gamma
C1 [Siegel, Steven J.] Univ Penn, Psychiat, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 751
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207501344
ER
PT J
AU Wang, H
Liang, S
Wang, MQ
Gao, JQ
Sun, CH
Wang, J
Xia, W
Wu, SY
Sumner, SJ
Zhang, FY
Sun, CH
Wu, LJ
AF Wang, Han
Liang, Shuang
Wang, Maoqing
Gao, Jingquan
Sun, Caihong
Wang, Jia
Xia, Wei
Wu, Shiying
Sumner, Susan J.
Zhang, Fengyu
Sun, Changhao
Wu, Lijie
TI Metabolomics Study of Autism for Biomarker Discovery in Han Chinese
Population
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism; serum biomarker; diagnosis; metabolomics; ultra-performance
liquid chromatography quadrupol
C1 [Wang, Han; Liang, Shuang; Gao, Jingquan; Sun, Caihong; Wang, Jia; Xia, Wei; Wu, Lijie] Harbin Med Univ, Sch Publ Hlth, Dept Child & Adolescent Hlth, Harbin, Peoples R China.
[Wang, Maoqing; Sun, Changhao] Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China.
[Wu, Shiying] SAS Inst Inc, Adv Analyt Div, Cary, NC USA.
[Sumner, Susan J.] Res Triangle Inst, Syst & Translat Sci, Res Triangle Pk, NC 27709 USA.
[Zhang, Fengyu] Johns Hopkins Univ, Lieber Inst Brain Dev, Baltimore, MD USA.
RI ahmed, Jamila/E-8653-2015
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 763
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207501356
ER
PT J
AU Watson, KK
Miller, S
Hannah, E
Kovac, M
Damiano, C
Sabatino, A
Turner-Brown, L
Sasson, N
Platt, M
Dichter, GS
AF Watson, Karli K.
Miller, Stephanie
Hannah, Eleanor
Kovac, Megan
Damiano, Cara
Sabatino, Antionette
Turner-Brown, Lauren
Sasson, Noah
Platt, Michael
Dichter, Gabriel S.
TI Autism Pay-per-view: Evidence for Differential Implicit Reward Value of
Social and Nonsocial Stimuli in Children with Autism from an Econometric
Choice Task
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism spectrum disorder; behavioral econometrics; restricted interests;
social
C1 [Watson, Karli K.] Univ Colorado, Inst Cognit Sci, Boulder, CO 80309 USA.
[Miller, Stephanie; Hannah, Eleanor; Kovac, Megan; Damiano, Cara; Sabatino, Antionette; Turner-Brown, Lauren] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC USA.
[Sasson, Noah] Univ Texas Dallas, Sch Behav & Brain Sci, Dallas, TX 75230 USA.
[Platt, Michael] Duke Univ, Neurobiol, Durham, NC USA.
[Dichter, Gabriel S.] Univ N Carolina, Psychiat, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 532
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207501126
ER
PT J
AU Stadlbauer, U
Labouesse, MA
Dong, E
Grayson, D
Guidotti, A
Meyer, U
AF Stadlbauer, Ulrike
Labouesse, Marie A.
Dong, Erbo
Grayson, Dennis
Guidotti, Alessandro
Meyer, Urs
TI Transgenerational Transmission and Modification of Behavioral Deficits
Induced by Prenatal Immune Activation
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism; Epigenetics; Immune System; Maternal Infection; Schizophrenia
C1 [Stadlbauer, Ulrike; Labouesse, Marie A.; Meyer, Urs] Swiss Fed Inst Technol, Physiol & Behav Lab, Schwerzenbach, Switzerland.
[Dong, Erbo; Grayson, Dennis; Guidotti, Alessandro] Univ Illinois, Coll Med, Dept Psychiat, Inst Psychiat, Chicago, IL USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 24
BP 9S
EP 9S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500025
ER
PT J
AU Bohorquez, D
White, RS
Port, RG
Carlson, GC
AF Bohorquez, Dominique
White, Rachel S.
Port, Russel G.
Carlson, Gregory C.
TI Disruption of Amygdalar Functional Connectivity in PCDH10
Haploinsufficient Mice (Pcdh10+/-)
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism; Amygdala; Voltage Sensitive Dye Imaging; Electrophysiology;
Protocadherin-10
C1 [Bohorquez, Dominique; White, Rachel S.; Port, Russel G.; Carlson, Gregory C.] Univ Penn, Psychiat, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 143
BP 52S
EP 52S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500136
ER
PT J
AU Ameis, S
Croarkin, P
Blumberger, D
Drmic, I
Desarkar, P
Mabbott, D
Szatmari, P
Daskalakis, J
AF Ameis, Stephanie
Croarkin, Paul
Blumberger, Daniel
Drmic, Irene
Desarkar, Pushpal
Mabbott, Donald
Szatmari, Peter
Daskalakis, Jeff
TI TMS for Executive Function Deficits in Youth with Autism Spectrum
Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism Spectrum Disorder; Executive Functioning; Repetitive Transcranial
Magnetic Stimulation; Brain Imaging; Clinical Trial
C1 [Ameis, Stephanie; Szatmari, Peter] Ctr Addict & Mental Hlth, Child Youth & Family, Toronto, ON, Canada.
[Ameis, Stephanie] Hosp Sick Children, Psychiat, Toronto, ON M5G 1X8, Canada.
[Croarkin, Paul] Mayo Clin, Childrens Ctr, Rochester, MN USA.
[Blumberger, Daniel; Daskalakis, Jeff] Ctr Addict & Mental Hlth, Temerty Ctr Therapeut Brain Intervent, Toronto, ON, Canada.
[Drmic, Irene; Mabbott, Donald] Hosp Sick Children, Psychol, Toronto, ON M5G 1X8, Canada.
[Desarkar, Pushpal] Ctr Addict & Mental Hlth, Dual Diag, Toronto, ON, Canada.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 181
BP 68S
EP 68S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500174
ER
PT J
AU Damiano, C
Miller, S
Hannah, E
Kovac, M
Aloi, J
Cockrell, D
Dunlap, K
Burrus, C
Kinsey, E
Bizzell, J
Dichter, GS
AF Damiano, Cara
Miller, Stephanie
Hannah, Eleanor
Kovac, Megan
Aloi, Joseph
Cockrell, Dillon
Dunlap, Kaitlyn
Burrus, Caley
Kinsey, Elizabeth
Bizzell, Joshua
Dichter, Gabriel S.
TI Neural Mechanisms of Uncertainty Processing in Children with Autism
Spectrum Disorders
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism spectrum disorder; insistence on sameness; uncertainty;
functional MRI
C1 [Damiano, Cara; Miller, Stephanie; Hannah, Eleanor; Kovac, Megan; Aloi, Joseph; Cockrell, Dillon; Dunlap, Kaitlyn; Burrus, Caley; Kinsey, Elizabeth; Bizzell, Joshua] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC USA.
[Dichter, Gabriel S.] Univ N Carolina, Psychiat, Chapel Hill, NC USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 183
BP 68S
EP 69S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500176
ER
PT J
AU Vellingiri, B
Subramaniam, M
Meyyazhagan, A
Krishnan, P
Iyer, M
AF Vellingiri, Balachandar
Subramaniam, Mohanadevi
Meyyazhagan, Arun
Krishnan, Padmavathy
Iyer, Mahalaxmi
TI Peripheral Blood Markers of Homocysteine, Paraoxonase1 (PON1) Activity
and Oxidative Stress in Autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism; antioxidant protein; homocysteine; human paraoxonase;
glutathione peroxidase
C1 [Vellingiri, Balachandar; Meyyazhagan, Arun; Krishnan, Padmavathy; Iyer, Mahalaxmi] Bharathiar Univ, Zool, Coimbatore, Tamil Nadu, India.
[Subramaniam, Mohanadevi] Dankook Univ, Anim Sci, Yongin, South Korea.
RI ahmed, Jamila/E-8653-2015
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 184
BP 69S
EP 69S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500177
ER
PT J
AU Ou, JJ
Guo, H
Hyde, TM
Xia, K
Hu, ZM
Kleinman, JE
Weinberger, DR
Zhao, JP
Zhang, FY
AF Ou, Jianjun
Guo, Hui
Hyde, Thomas M.
Xia, Kun
Hu, Zhengmao
Kleinman, Joel E.
Weinberger, Daniel R.
Zhao, Jingping
Zhang, Fengyu
TI ULK4 Genetic Variants Associate with risk of Autism and Its Gene
Expression in Human Postmortem brains
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism; ULK4; Genetic Variants; Postmortem brains
C1 [Ou, Jianjun; Zhao, Jingping] Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
[Guo, Hui; Xia, Kun; Hu, Zhengmao] Cent S Univ, State Key Lab Med Genet, Changsha, Hunan, Peoples R China.
[Hyde, Thomas M.; Kleinman, Joel E.; Weinberger, Daniel R.; Zhang, Fengyu] Johns Hopkins Sch Med, Lieber Inst Brain Dev, Baltimore, MD USA.
[Hyde, Thomas M.; Kleinman, Joel E.; Weinberger, Daniel R.] Johns Hopkins Sch Med, Dept Psychiat, Neurol, Baltimore, MD USA.
[Weinberger, Daniel R.] Johns Hopkins Sch Med, Inst Genom Med, Baltimore, MD USA.
RI ahmed, Jamila/E-8653-2015
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 227
BP 86S
EP 86S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500220
ER
PT J
AU Shen, YD
Xun, GL
Dong, HX
Ou, JJ
Xia, K
Zhao, JP
AF Shen, Yidong
Xun, Guanglei
Dong, Huixi
Ou, Jianjun
Xia, Kun
Zhao, Jingping
TI Association and Gene-gene Interactions Study of Reelin Signaling Pathway
Related Genes with Autism in Chinese Han Population
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism; Reelin; Gene-Gene interaction
C1 [Shen, Yidong; Xun, Guanglei; Dong, Huixi; Ou, Jianjun; Xia, Kun; Zhao, Jingping] Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
RI ahmed, Jamila/E-8653-2015
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 228
BP 87S
EP 87S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500221
ER
PT J
AU Park, MTM
Raznahan, A
Shaw, P
Gogtay, N
Chakravarty, MM
AF Park, Min Tae M.
Raznahan, Armin
Shaw, Philip
Gogtay, Nitin
Chakravarty, M. Mallar
TI Shared Cerebellar Phenotypes in Autism Spectrum Disorders and
Schizophrenia
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Cerebellum; Autism; Schizophrenia; MRI
C1 [Park, Min Tae M.; Chakravarty, M. Mallar] Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Montreal, PQ, Canada.
[Raznahan, Armin; Gogtay, Nitin] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA.
[Shaw, Philip] NHGRI, Sect Neurobehav Clin Res, Social & Behav Res Branch, Bethesda, MD 20892 USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 268
BP 103S
EP 104S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500261
ER
PT J
AU Khundrakpam, B
Lewis, J
Kostopoulos, P
Evans, A
AF Khundrakpam, Budhachandra
Lewis, John
Kostopoulos, Penelope
Evans, Alan
TI Altered Cortical Trajectories in Autism Spectrum Disorders: Relation to
Symptomatology
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Autism spectrum disorders; Cortical trajectories; Neuroimaging; Symptom
severity; Behavior
C1 [Khundrakpam, Budhachandra; Lewis, John; Kostopoulos, Penelope; Evans, Alan] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 270
BP 104S
EP 105S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500263
ER
PT J
AU Vasa, RA
Tang, XY
Crocetti, D
Miller, MI
Mostofsky, SH
AF Vasa, Roma A.
Tang, Xiaoying
Crocetti, Deana
Miller, Michael I.
Mostofsky, Stewart H.
TI Amygdala and Hippocampal Morphology in Children with High Functioning
Autism Spectrum Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE autism spectrum disorders; amygdala; hippoccampal; morphology; children
C1 [Vasa, Roma A.; Crocetti, Deana; Mostofsky, Stewart H.] Kennedy Krieger Inst, Ctr Neurodev & Imaging Res, Baltimore, MD USA.
[Tang, Xiaoying; Miller, Michael I.] Johns Hopkins Univ, Ctr Imaging Sci, Baltimore, MD USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 269
BP 104S
EP 104S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500262
ER
PT J
AU Cochran, DM
Kennedy, DN
Hodge, S
Frazier, JA
AF Cochran, David M.
Kennedy, David N.
Hodge, Steven
Frazier, Jean A.
TI Altered Striatal Resting-State Connectivity to Sensory and Language
Processing Cortical Areas in Autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE autism; resting state fMRI; neuroimaging; striatum; functional
connectivity
C1 [Cochran, David M.; Kennedy, David N.; Hodge, Steven; Frazier, Jean A.] Univ Massachusetts, Sch Med, Psychiat, Worcester, MA USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 273
BP 106S
EP 106S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207500266
ER
PT J
AU Rannals, MD
Cerceo-Page, S
Campbell, M
Hamersky, G
Gallo, R
Shin, JH
Hyde, TM
Kleinman, J
Jaffe, AE
Weinberger, DR
Maher, BJ
AF Rannals, Matthew D.
Cerceo-Page, Stephanie
Campbell, Morganne
Hamersky, Gregory
Gallo, Ryan
Shin, Joo Heon
Hyde, Thomas M.
Kleinman, Joel
Jaffe, Andrew E.
Weinberger, Daniel R.
Maher, Brady J.
TI The Schizophrenia and Autism Spectrum Disorder Gene TCF4 Regulates the
Intrinsic Excitability of Prefrontal Neurons
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE schizophrenia; autism; TCF4; animal model; electrophysiology
C1 [Rannals, Matthew D.; Cerceo-Page, Stephanie; Campbell, Morganne; Hamersky, Gregory; Gallo, Ryan; Maher, Brady J.] Lieber Inst Brain Dev, Dev Electrophysiol, Baltimore, MD USA.
[Shin, Joo Heon; Kleinman, Joel; Jaffe, Andrew E.; Weinberger, Daniel R.] Lieber Inst Brain Dev, Genet Epigenet & Bioinformat, Baltimore, MD USA.
[Hyde, Thomas M.] Lieber Inst Brain Dev, Neuropathol, Baltimore, MD USA.
[Maher, Brady J.] Johns Hopkins Sch Med, Psychiat & Behav Sci, Baltimore, MD USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 859
BP 308S
EP 308S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207502060
ER
PT J
AU Boisgontier, J
Beggiato, A
Toro, R
Duchesnay, E
Poupon, C
Amsellem, F
Katz, J
Petit, J
Monnet, D
D'Albis, MA
Delphine, D
Aline, L
Le Dudal, K
Scimia, N
Lettelier, L
Leboyer, M
Bourgeron, T
Elmaleh, M
Sebag, G
Germanaud, D
Delorme, R
Houenou, J
AF Boisgontier, Jennifer
Beggiato, Anita
Toro, Roberto
Duchesnay, Edouard
Poupon, Cyril
Amsellem, Frederique
Katz, Julien
Petit, Julie
Monnet, David
D'Albis, Marc Antoine
Delphine, Duclap
Aline, Lefebvre
Le Dudal, Katia
Scimia, Nelly
Lettelier, Laurence
Leboyer, Marion
Bourgeron, Thomas
Elmaleh, Monique
Sebag, Guy
Germanaud, David
Delorme, Richard
Houenou, Josselin
TI Fronto-occipital Disconnectivity as a Familial Risk Marker of Autism
Spectrum Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE autism spectrum disorders; first-degree relatives; diffusion tensor
imaging; magnetic resonance; genetic
C1 [Boisgontier, Jennifer; Katz, Julien; Petit, Julie; Monnet, David; D'Albis, Marc Antoine; Houenou, Josselin] Hop Henri Mondor, INSERM, U955, Equipe Equipe Psychopathol & Genet Malad Psychiat, F-94010 Creteil, France.
[Beggiato, Anita; Toro, Roberto; Bourgeron, Thomas] Inst Pasteur, Human Genet & Cognit Funct, Paris, France.
[Duchesnay, Edouard] CEA Saclay, I2BM, Neurospin, UNATI, F-91191 Gif Sur Yvette, France.
[Poupon, Cyril; Delphine, Duclap] CEA Saclay, I2BM, Neurospin, UNIRS, F-91191 Gif Sur Yvette, France.
[Amsellem, Frederique; Elmaleh, Monique; Sebag, Guy] Robert Debre Hosp, Dept Pediat Imaging, Paris, France.
[Aline, Lefebvre] CHU Caen, Esquirol Ctr, F-14000 Caen, France.
[Le Dudal, Katia] Hop Henri Mondor, AP HP, CIC 1430, F-94010 Creteil, France.
[Scimia, Nelly; Lettelier, Laurence; Germanaud, David; Delorme, Richard] Robert Debre Hosp, Chils & Adolescent Psychiat Unit, Paris, France.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 1004
BP 363S
EP 364S
PG 2
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207502197
ER
PT J
AU Featherstone, RE
Liang, YL
Nagy, L
Shin, R
Kogan, JH
Matsumoto, M
Siegel, SJ
AF Featherstone, Robert E.
Liang, Yuling
Nagy, Lauren
Shin, Rick
Kogan, Jeffery H.
Matsumoto, Mitsuyuki
Siegel, Steven J.
TI Baclofen Restores Excitatory-inhibitory Balance in 15q13.3 Deletion Mice
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE EEG; Gamma oscillation; Autism; Copy number variation; GABA
C1 [Featherstone, Robert E.; Liang, Yuling; Nagy, Lauren; Siegel, Steven J.] Univ Penn, Psychiat Translat Neurosci, Philadelphia, PA 19104 USA.
[Shin, Rick; Kogan, Jeffery H.] Astellas Res Inst Amer LLC, CNS, Skokie, IL USA.
[Matsumoto, Mitsuyuki] Astellas Res Inst Japan LLC, CNS, Tokyo, Japan.
RI ahmed, Jamila/E-8653-2015
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 1092
BP 399S
EP 399S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207502285
ER
PT J
AU Page, SC
Rannals, MD
Campbell, MN
Briley, A
Gallo, RA
Mayfield, B
Phan, BN
Weinberger, DR
Maher, BJ
AF Page, Stephanie C.
Rannals, Matthew D.
Campbell, Morganne N.
Briley, Aaron
Gallo, Ryan A.
Mayfield, Brent
Phan, BaDoi N.
Weinberger, Daniel R.
Maher, Brady J.
TI The Schizophrenia and Autism Associated Gene, Transcription Factor 4,
Regulates Cortical Column Formation in the Prefrontal Cortex
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 70th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
on Stress, Emotion, Neurodevelopment and Psychopathology
CY MAY 14-16, 2015
CL Toronto, CANADA
SP Soc Biol Psychiat
DE Transcription Factor 4; Neural Differentiation; Neural Migration
C1 [Page, Stephanie C.; Rannals, Matthew D.; Campbell, Morganne N.; Briley, Aaron; Gallo, Ryan A.; Mayfield, Brent; Phan, BaDoi N.; Maher, Brady J.] Lieber Inst Brain Dev, Div Dev Electrophysiol, Baltimore, MD USA.
[Weinberger, Daniel R.] Lieber Inst Brain Dev, Genet Epigenet & Bioinformat, Baltimore, MD USA.
[Weinberger, Daniel R.; Maher, Brady J.] Johns Hopkins Sch Med, Psychiat & Behav Sci, Baltimore, MD USA.
[Weinberger, Daniel R.; Maher, Brady J.] Johns Hopkins Sch Med, Neurosci, Baltimore, MD USA.
[Weinberger, Daniel R.] Johns Hopkins Sch Med, Inst Genet Med, Baltimore, MD USA.
NR 0
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
SU S
MA 1136
BP 416S
EP 416S
PG 1
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CF0BM
UT WOS:000352207502328
ER
PT J
AU Esan, F
Chester, V
Gunaratna, IJ
Hoare, S
Alexander, RT
AF Esan, Fola
Chester, Verity
Gunaratna, Ignatius J.
Hoare, Sudeep
Alexander, Regi T.
TI The Clinical, Forensic and Treatment Outcome Factors of Patients with
Autism Spectrum Disorder Treated in a Forensic Intellectual Disability
Service
SO JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
LA English
DT Article
DE autistic spectrum disorder; comorbidity; forensic; intellectual
disability; learning disability; treatment outcomes
ID ASPERGERS-SYNDROME; OFFENDING BEHAVIOR; VIOLENCE; ADULTS; SAMPLE; LAW
AB Background To describe the characteristics of those with autism spectrum disorder (ASD) treated within a forensic intellectual disability hospital and to compare them with those without ASD.
Method Service evaluation of a cohort of 138 patients treated over a 6-year period.
Results Of the 138, 42 had an ASD. Personality disorders and harmful use or dependence on drugs were significantly lower in the ASD group. The ASD group was less likely to be subject to criminal sections or restriction orders. Self-harm was significantly higher in the ASD group. There were no differences in the length of stay and direction of care pathway.
Conclusions Although the ASD and non-ASD groups differ on clinical and forensic characteristics, their treatment outcomes appear similar. This suggests that the diagnostic category of ASD alone may be inadequate in predicting the treatment outcome. There is a case to identify distinct typologies within the ASD group.
C1 [Esan, Fola; Chester, Verity; Gunaratna, Ignatius J.; Hoare, Sudeep; Alexander, Regi T.] Partnerships Care Learning Disabil Serv, Diss IP22 1BA, Norfolk, England.
[Alexander, Regi T.] Univ E Anglia, Norwich NR4 7TJ, Norfolk, England.
RP Alexander, RT (reprint author), Partnerships Care Learning Disabil Serv, St Johns House,Lion Rd, Diss IP22 1BA, Norfolk, England.
EM regi.alexander@-btinternet.com
CR Alexander R. T., 2011, ADV MENTAL HLTH INTE, V5, P22, DOI DOI 10.5042/AMHID.2011.0013
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Allen D, 2008, J AUTISM DEV DISORD, V38, P748, DOI 10.1007/s10803-007-0442-9
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
Archer N., 2013, J INTELL DISABIL RES, V4, P53
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World Health Organisation, 1992, ICD 10 CLASS MENT BE
NR 48
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1360-2322
EI 1468-3148
J9 J APPL RES INTELLECT
JI J. Appl. Res. Intellect. Disabil.
PD MAY
PY 2015
VL 28
IS 3
BP 193
EP 200
DI 10.1111/jar.12121
PG 8
WC Psychology, Educational; Rehabilitation
SC Psychology; Rehabilitation
GA CF8IE
UT WOS:000352799100003
PM 25379816
ER
PT J
AU Curran, EA
O'Neill, SM
Cryan, JF
Kenny, LC
Dinan, TG
Khashan, AS
Kearney, PM
AF Curran, Eileen A.
O'Neill, Sinead M.
Cryan, John F.
Kenny, Louise C.
Dinan, Timothy G.
Khashan, Ali S.
Kearney, Patricia M.
TI Research Review: Birth by caesarean section and development of autism
spectrum disorder and attention-deficit/hyperactivity disorder: a
systematic review and meta-analysis
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Review
DE Autism spectrum disorder; attention-deficit; hyperactivity disorder;
Caesarean section
ID PERINATAL RISK-FACTORS; INFANTILE-AUTISM; HYPERACTIVITY DISORDER;
NEONATAL FACTORS; DELIVERY; CHILDREN; COMPLICATIONS; POPULATION;
MICROBIOTA; ASSOCIATION
AB BackgroundGiven the growing prevalence of birth by Caesarean section (CS) worldwide, it is important to understand any long-term effects CS delivery may have on a child's development. We assessed the impact of mode of delivery on autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD).
MethodsWe conducted a systematic review of the literature in PubMed, Embase, CINAHL, PsycINFO and Web of Science up to 28 February 2014. No publication date, language, location or age restrictions were employed.
ResultsThirteen studies reported an adjusted estimate for CS-ASD, producing a pooled odds ratio (OR) of 1.23 (95% CI: 1.07, 1.40). Two studies reported an adjusted estimate for CS-ADHD, producing a pooled OR of 1.07 (95% CI: 0.86, 1.33).
ConclusionsDelivery by CS is associated with a modest increased odds of ASD, and possibly ADHD, when compared to vaginal delivery. Although the effect may be due to residual confounding, the current and accelerating rate of CS implies that even a small increase in the odds of disorders, such as ASD or ADHD, may have a large impact on the society as a whole. This warrants further investigation.
C1 [Curran, Eileen A.; O'Neill, Sinead M.; Kenny, Louise C.; Khashan, Ali S.] Natl Univ Ireland Univ Coll Cork, Dept Obstet & Gynaecol, Irish Ctr Fetal & Neonatal Translat Res INFANT, Cork, Ireland.
[O'Neill, Sinead M.] Cork Univ, Matern Hosp, Anu Res Ctr, Dept Obstet & Gynaecol,Natl Perinatal Epidemiol C, Cork, Ireland.
[Cryan, John F.] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Dept Anat & Neurosci, Cork, Ireland.
[Dinan, Timothy G.] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Alimentary Pharmabiot Ctr, Cork, Ireland.
[Khashan, Ali S.; Kearney, Patricia M.] Natl Univ Ireland Univ Coll Cork, Dept Epidemiol & Publ Hlth, Cork, Ireland.
RP Curran, EA (reprint author), Cork Univ, Matern Hosp, 5th Floor, Cork, Ireland.
EM ecurran@ucc.ie
FU Science Foundation Ireland (SFI) [12\RC\2272]
FX This work was carried out at The Irish Centre for Fetal and Neonatal
Translational Research (INFANT) (Science Foundation Ireland (SFI) funded
Centre, Grant number 12 vertical bar RC vertical bar 2272). The authors
have declared that they have no competing or potential conflicts of
interest.
CR Al-Jammas I. K., 2012, ARAB J PSYCHIAT, V23, P108
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NR 54
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD MAY
PY 2015
VL 56
IS 5
BP 500
EP 508
DI 10.1111/jcpp.12351
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA CF4YQ
UT WOS:000352560900002
PM 25348074
ER
PT J
AU Hirschler-Guttenberg, Y
Golan, O
Ostfeld-Etzion, S
Feldman, R
AF Hirschler-Guttenberg, Yael
Golan, Ofer
Ostfeld-Etzion, Sharon
Feldman, Ruth
TI Mothering, fathering, and the regulation of negative and positive
emotions in high-functioning preschoolers with autism spectrum disorder
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorder; emotion regulation; emotional reactivity;
mothering; fathering
ID SELF-REGULATION; EMPIRICAL-EVIDENCE; CHILDREN; EXPRESSION; STRATEGIES;
SYNCHRONY; ANGER; TEMPERAMENT; RECOGNITION; CHILDHOOD
AB BackgroundChildren with autism spectrum disorder (ASD) exhibit difficulties in regulating emotions and authors have called to study the specific processes underpinning emotion regulation (ER) in ASD. Yet, little observational research examined the strategies preschoolers with ASD use to regulate negative and positive emotions in the presence of their mothers and fathers.
MethodsForty preschoolers with ASD and 40 matched typically developing children and their mothers and fathers participated. Families were visited twice for identical battery of paradigms with mother or father. Parent-child interactions were coded for parent and child behaviors and children engaged in ER paradigms eliciting negative (fear) and positive (joy) emotions with each parent. ER paradigms were microcoded for negative and positive emotionality, ER strategies, and parent regulation facilitation.
ResultsDuring free play, mothers' and fathers' sensitivity and warm discipline were comparable across groups; however, children with ASD displayed lower positive engagement and higher withdrawal. During ER paradigms, children with ASD expressed less positive emotionality overall and more negative emotionality during fear with father. Children with ASD used more simple self-regulatory strategies, particularly during fear, but expressed comparable levels of assistance seeking behavior toward mother and father in negative and positive contexts. Parents of children with ASD used less complex regulation facilitation strategies, including cognitive reappraisal and emotional reframing, and employed simple tactics, such as physical comforting to manage fear and social gaze to maintain joy.
ConclusionFindings describe general and parent- and emotion-specific processes of child ER and parent regulation facilitation in preschoolers with ASD. Results underscore the ability of such children to seek parental assistance during moments of high arousal and the parents' sensitive adaptation to their children's needs. Reduced positive emotionality, rather than increased negative reactivity and self-regulatory efforts, emerges as the consistent element associated with ER processes in this group.
C1 [Hirschler-Guttenberg, Yael; Golan, Ofer; Ostfeld-Etzion, Sharon; Feldman, Ruth] Bar Ilan Univ, Dept Psychol, IL-52900 Ramat Gan, Israel.
[Golan, Ofer] Assoc Children Risk, Tel Aviv, Israel.
[Feldman, Ruth] Bar Ilan Univ, Gonda Brain Res Ctr, IL-52900 Ramat Gan, Israel.
RP Feldman, R (reprint author), Bar Ilan Univ, Dept Psychol, IL-52900 Ramat Gan, Israel.
EM Feldman@mail.biu.ac.il
RI ahmed, Jamila/E-8653-2015
FU Association for Children at Risk, Ramat-Hen, Israel; US-Israel
Bi-National Science Foundation
FX The study was supported by the Association for Children at Risk,
Ramat-Hen, Israel and by the US-Israel Bi-National Science Foundation.
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NR 52
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD MAY
PY 2015
VL 56
IS 5
BP 530
EP 539
DI 10.1111/jcpp.12311
PG 10
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA CF4YQ
UT WOS:000352560900005
PM 25123380
ER
PT J
AU de Vries, M
Prins, PJM
Schmand, BA
Geurts, HM
AF de Vries, Marieke
Prins, Pier J. M.
Schmand, Ben A.
Geurts, Hilde M.
TI Working memory and cognitive flexibility-training for children with an
autism spectrum disorder: a randomized controlled trial
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Executive functioning; working memory; flexibility; cognitive training;
autism
ID QUALITY-OF-LIFE; SOCIAL RESPONSIVENESS SCALE; GENERIC CORE SCALES;
EXECUTIVE FUNCTION; DIAGNOSTIC INTERVIEW; PRESCHOOL-CHILDREN; ADHD;
TASK; PEDSQL(TM)-4.0; VALIDITY
AB BackgroundPeople with autism spectrum disorders (ASDs) experience executive function (EF) deficits. There is an urgent need for effective interventions, but in spite of the increasing research focus on computerized cognitive training, this has not been studied in ASD. Hence, we investigated two EF training conditions in children with ASD.
MethodsIn a randomized controlled trial, children with ASD (n=121, 8-12years, IQ>80) were randomly assigned to an adaptive working memory (WM) training, an adaptive cognitive flexibility-training, or a non-adaptive control training (mock-training). Braingame Brian, a computerized EF-training with game-elements, was used. Outcome measures (pretraining, post-training, and 6-week-follow-up) were near-transfer to trained EFs, far-transfer to other EFs (sustained attention and inhibition), and parent's ratings of daily life EFs, social behavior, attention deficit hyperactivity disorder (ADHD)-behavior, and quality of life.
ResultsAttrition-rate was 26%. Children in all conditions who completed the training improved in WM, cognitive flexibility, attention, and on parent's ratings, but not in inhibition. There were no significant differential intervention effects, although children in the WM condition showed a trend toward improvement on near-transfer WM and ADHD-behavior, and children in the cognitive flexibility condition showed a trend toward improvement on near-transfer flexibility.
ConclusionAlthough children in the WM condition tended to improve more in WM and ADHD-behavior, the lack of differential improvement on most outcome measures, the absence of a clear effect of the adaptive training compared to the mock-training, and the high attrition rate suggest that the training in its present form is probably not suitable for children with ASD.
C1 [de Vries, Marieke; Prins, Pier J. M.; Schmand, Ben A.; Geurts, Hilde M.] Univ Amsterdam, NL-1018 XA Amsterdam, Netherlands.
[de Vries, Marieke; Geurts, Hilde M.] Dutch Autism & ADHD Res Ctr, Amsterdam, Netherlands.
[Schmand, Ben A.] Acad Med Ctr Amsterdam, Amsterdam, Netherlands.
[Geurts, Hilde M.] Dr Leo Kannerhuis, Amsterdam, Netherlands.
RP de Vries, M (reprint author), Univ Amsterdam, Dept Psychol, Brain & Cognit, Weesperpl 4, NL-1018 XA Amsterdam, Netherlands.
EM m.devries@uva.nl
FU University of Amsterdam
FX The study was approved by the ethics committee of the Academic Medical
Center Amsterdam (METC 2010-185), and registered in the Dutch trial
register (NL32255.018.10). Study funding was provided by the University
of Amsterdam. P.J.M.P. is member of the foundation Gaming and Training,
a nonprofit organization that develops and evaluates online
interventions, such as EF training, for youth mental health care. The
other authors have declared that they have no competing or potential
conflicts of interest. The authors thank all the children and their
parents for participating in the study; the students for testing the
participants; and the mental health care institutions for helping with
patient recruitment.
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Zinke K, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00041
NR 74
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD MAY
PY 2015
VL 56
IS 5
BP 566
EP 576
DI 10.1111/jcpp.12324
PG 11
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA CF4YQ
UT WOS:000352560900009
PM 25256627
ER
PT J
AU Jones, RM
Risi, S
Wexler, D
Anderson, D
Corsello, C
Pickles, A
Lord, C
AF Jones, Rebecca M.
Risi, Susan
Wexler, Diana
Anderson, Deborah
Corsello, Christina
Pickles, Andrew
Lord, Catherine
TI How interview questions are placed in time influences caregiver
description of social communication symptoms on the ADI-R
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorders; ADI-R; parent report; longitudinal; diagnosis
ID AUTISM SPECTRUM DISORDERS; DIAGNOSTIC INTERVIEW; SEVERITY; SCORES;
SCHEDULE; CHILDREN; AGE
AB BackgroundCaregiver report is crucial for the diagnosis of childhood onset psychiatric disorders, particularly autism. Three experiments were conducted to determine whether caregiver reports of past and current behaviors are affected by question timing and ordering.
MethodsUsing the Autism Diagnostic Interview - Revised (ADI-R), two studies systematically varied the order in which caregivers were asked about behaviors. In a third study, descriptions of children's current behaviors at age 5 were compared to retrospective descriptions of behaviors at age 5 collected at age 10.
ResultsCaregivers, who were first asked about a history of symptoms, described less severe past and present behavior than caregivers reporting current behaviors as well as caregivers reporting current and history of symptoms together. Caregivers retrospectively reported more severe behaviors for age 5 when their children were age 10 than they had when their children were age 5.
ConclusionsCaregivers describe past behaviors differently depending on whether they are asked about current symptoms first. Methods of caregiver reporting can influence interpretations of symptom severity with effects on diagnoses and research findings.
C1 [Jones, Rebecca M.; Wexler, Diana; Anderson, Deborah; Lord, Catherine] New York Presbyterian Hosp, Weill Cornell Med Coll, Ctr Autism & Dev Brain, White Plains, NY 10605 USA.
[Risi, Susan] Eastern Michigan Univ, Autism Collaborat Ctr, Ypsilanti, MI 48197 USA.
[Corsello, Christina] Rady Childrens Hosp, San Diego, CA USA.
[Pickles, Andrew] Kings Coll London, Inst Psychiat, Dept Biostat, London WC2R 2LS, England.
RP Jones, RM (reprint author), New York Presbyterian Hosp, Weill Cornell Med Coll, Ctr Autism & Dev Brain, 21 Bloomingdale Rd, White Plains, NY 10605 USA.
EM rej2004@med.cornell.edu
RI Pickles, Andrew/A-9625-2011
OI Pickles, Andrew/0000-0003-1283-0346
FU National Institute of Mental Health [NIMH RO1 MH081873-04,
1R01HD073975-01]; Autism Speaks Meixner Fellowship [7608]; Health
Resources Services Administration [HRSA UA3-MC-11055]
FX This study was funded by the National Institute of Mental Health (NIMH
RO1 MH081873-04 and 1R01HD073975-01), Autism Speaks Meixner Fellowship
(7608), and the Health Resources Services Administration (HRSA
UA3-MC-11055).
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American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 27
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD MAY
PY 2015
VL 56
IS 5
BP 577
EP 585
DI 10.1111/jcpp.12325
PG 9
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA CF4YQ
UT WOS:000352560900010
PM 25243378
ER
PT J
AU Maffini, MV
Neltner, TG
AF Maffini, Maricel V.
Neltner, Thomas G.
TI Brain drain: the cost of neglected responsibilities in evaluating
cumulative effects of environmental chemicals
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
ID PUBLIC-HEALTH; DISABILITIES
AB Developmental disabilities affect millions of people and have a great impact on their lives, their families and the societies where they live. The prevalence of disorders such as autism, attention deficit hyperactivity disorder as well as subclinical decrements in brain function cannot be explained solely as genetic diseases. Exposures to environmental chemicals, especially during prenatal and early postnatal life, are one likely explanation for some of the decrements. The current chemical risk assessment approach is typically based on the toxicity caused by a single chemical on a variety of organs without acknowledging additional exposures to other chemicals also affecting the same organ or system. We identified more than 300 chemicals allowed in food that may have potential harmful effects on the developing brain. Each individual chemical may or may not have a harmful effect if it were the only one present, but we know next to nothing about their cumulative biological effects on the brain. An expanded cumulative risk assessment approach is needed, and it should focus on health outcomes, like developmental disabilities, arising from the accumulation of effects of multiple chemicals on the brain. The laws regulating the safety of additives already require that regulators in Europe and the USA consider cumulative effects; so far, they seem to have neglected the mandate. We must move beyond treating chemical exposures as isolated incidents and look at their cumulative biological effects on organs and their role in the onset of chronic diseases. The time has come to overhaul chemical risk assessment.
C1 [Maffini, Maricel V.; Neltner, Thomas G.] Nat Resources Def Council, Washington, DC 20005 USA.
RP Maffini, MV (reprint author), Nat Resources Def Council, 1152 15th St NW, Washington, DC 20005 USA.
EM drmvma@gmail.com
FU Pew Charitable Trusts
FX This work was supported by a grant from The Pew Charitable Trusts to the
Natural Resources Defense Council.
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National Academy of Sciences National Research Council Committee on the Health Risks of Phthalates, 2008, PHTHAL CUM RISK ASS
National Center for Advancing Translational Sciences, TOX 21 CENT
Neltner TG, 2013, REPROD TOXICOL, V42, P85, DOI 10.1016/j.reprotox.2013.07.023
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U.S. Environmental Protection Agency, 2014, ASS PEST CUM RISK
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World Health Organization, 2010, GLOB STAT REP NONC D
NR 24
TC 0
Z9 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
EI 1470-2738
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD MAY
PY 2015
VL 69
IS 5
BP 496
EP 499
DI 10.1136/jech-2014-203980
PG 4
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA CF4TR
UT WOS:000352545300016
PM 25336676
ER
PT J
AU Dimitriou, D
Leonard, HC
Karmiloff-Smith, A
Johnson, MH
Thomas, MSC
AF Dimitriou, D.
Leonard, H. C.
Karmiloff-Smith, A.
Johnson, M. H.
Thomas, M. S. C.
TI Atypical development of configural face recognition in children with
autism, Down syndrome and Williams syndrome
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE autism; configural processing; Down syndrome; face recognition;
inversion effect; Williams syndrome
ID SPECTRUM DISORDERS; INFORMATION; EYE; DISCRIMINATION; PROSOPAGNOSIA;
TRAJECTORIES; INDIVIDUALS; ATTENTION; PATTERNS; IDENTITY
AB BackgroundConfigural processing in face recognition is a sensitivity to the spacing between facial features. It has been argued both that its presence represents a high level of expertise in face recognition, and also that it is a developmentally vulnerable process.
MethodWe report a cross-syndrome investigation of the development of configural face recognition in school-aged children with autism, Down syndrome and Williams syndrome compared with a typically developing comparison group. Cross-sectional trajectory analyses were used to compare configural and featural face recognition utilising the Jane faces' task. Trajectories were constructed linking featural and configural performance either to chronological age or to different measures of mental age (receptive vocabulary, visuospatial construction), as well as the Benton face recognition task.
ResultsAn emergent inversion effect across age for detecting configural but not featural changes in faces was established as the marker of typical development. Children from clinical groups displayed atypical profiles that differed across all groups.
ConclusionWe discuss the implications for the nature of face processing within the respective developmental disorders, and how the cross-sectional syndrome comparison informs the constraints that shape the typical development of face recognition.
C1 [Dimitriou, D.] Univ London, Inst Educ, Dept Psychol & Human Dev, London WC1N 1AZ, England.
[Leonard, H. C.; Karmiloff-Smith, A.; Johnson, M. H.; Thomas, M. S. C.] Univ London, Ctr Brain & Cognit Dev, Birkbeck, London, England.
RP Dimitriou, D (reprint author), Inst Educ, Dept Psychol & Human Dev, London WC1H 0AL, England.
EM d.dimitriou@ioe.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 47
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD MAY
PY 2015
VL 59
IS 5
BP 422
EP 438
DI 10.1111/jir.12141
PG 17
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
Rehabilitation
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
Neurology; Psychiatry; Rehabilitation
GA CF5BI
UT WOS:000352569300003
PM 25059077
ER
PT J
AU Pulido, R
AF Pulido, Rafael
TI PTEN: A yin-yang master regulator protein in health and disease
SO METHODS
LA English
DT Article
DE PTEN; Lipid phosphatase; Protein tyrosine phosphatase; Oncogenesis;
Tumor suppression; Diabetes; Neurosurvival; Neuroregeneration
ID TUMOR-SUPPRESSOR PTEN; AUTISM SPECTRUM DISORDERS;
BANNAYAN-ZONANA-SYNDROME; GROWTH-FACTOR RECEPTOR; TENSIN HOMOLOG PTEN;
PHOSPHATASE-ACTIVITY; SIGNALING PATHWAY; INSULIN HYPERSENSITIVITY;
CAENORHABDITIS-ELEGANS; TYROSINE-PHOSPHATASE
AB The PTEN gene is a tumor suppressor gene frequently mutated in human tumors, which encodes a ubiquitous protein whose major activity is to act as a lipid phosphatase that counteracts the action of the oncogenic PI3K. In addition, PTEN displays protein phosphatase- and catalytically-independent activities. The physiologic control of PTEN function, and its inactivation in cancer and other human diseases, including some neurodevelopmental disorders, is upon the action of multiple regulatory mechanisms. This provides a wide spectrum of potential therapeutic approaches to reconstitute PTEN activity. By contrast, inhibition of PTEN function may be beneficial in a different group of human diseases, such as type 2 diabetes or neuroregeneration-related pathologies. This makes PTEN a functionally dual yin-yang protein with high potential in the clinics. Here, a brief overview on PTEN and its relation with human disease is presented. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Pulido, Rafael] BioCruces Hlth Res Inst, Baracaldo 48903, Bizkaia, Spain.
[Pulido, Rafael] Ikerbasque, Basque Fdn Sci, E-48011 Bilbao, Spain.
RP Pulido, R (reprint author), BioCruces Hlth Res Inst, Pza Cruces S-N, Baracaldo 48903, Bizkaia, Spain.
EM rpulido@gmail.com
FU Ministerio de Economia y Competitividad (Spain) [SAF2013-48812-R];
Gobierno Vasco, Departamento de Salud (Basque Country, Spain)
[2013111011]; BIOEF/EITB maratoia (Basque Country, Spain)
[BIO13/CI/001/BC]
FX I thank Nick Leslie for comments to the manuscript. Work in R.P. lab is
supported in part by Grants SAF2013-48812-R from Ministerio de Economia
y Competitividad (Spain), 2013111011 from Gobierno Vasco, Departamento
de Salud (Basque Country, Spain), and BIO13/CI/001/BC from BIOEF/EITB
maratoia (Basque Country, Spain).
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NR 211
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1046-2023
EI 1095-9130
J9 METHODS
JI Methods
PD MAY 1
PY 2015
VL 77-78
BP 3
EP 10
DI 10.1016/j.ymeth.2015.02.009
PG 8
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CF9XV
UT WOS:000352922000002
PM 25843297
ER
PT J
AU Ngeow, J
Eng, C
AF Ngeow, Joanne
Eng, Charis
TI PTEN hamartoma tumor syndrome: Clinical risk assessment and management
protocol
SO METHODS
LA English
DT Article
DE PTEN hamartoma tumor syndrome; Tumor suppressor; PI3K/AKT signaling;
Cancer
ID COWDEN-LIKE SYNDROME; GENOTYPE-PHENOTYPE CORRELATIONS; AUTISM SPECTRUM
DISORDERS; RILEY-RUVALCABA-SYNDROMES; BANNAYAN-ZONANA-SYNDROME; GERMLINE
PTEN; THYROID-CANCER; BREAST-CANCER; DIFFERENTIAL EXPRESSION; PROMOTER
MUTATIONS
AB The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is an important phosphatase that counteracts one of the most critical cancer pathways: the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathways. Clinically, deregulation of PTEN function resulting in reduced PTEN expression and activity is implicated in human diseases. Cowden syndrome (CS) is an autosomal dominant disorder characterized by benign and malignant tumors. CS-related individual features occur commonly in the general population. Approximately 25% of patients diagnosed with CS have pathogenic germline PTEN mutations, which increase lifetime risks of breast, thyroid, uterine, renal and other cancers. PTEN testing and intensive cancer surveillance allow for early detection and treatment of these cancers for mutation positive patients and their relatives. In this review, we highlight our current knowledge of germline PTEN mutations in relation to human disease. We review current clinical diagnosis and management recommendations for PHTS including recent discoveries in understanding PTEN function regulation and how this can be exploited therapeutically. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Ngeow, Joanne; Eng, Charis] Cleveland Clin, Genom Med Inst, Cleveland, OH 44195 USA.
[Eng, Charis] Cleveland Clin, Lerner Res Inst, Cleveland, OH 44195 USA.
[Ngeow, Joanne] Natl Canc Ctr, Div Med Oncol, Singapore 169610, Singapore.
[Ngeow, Joanne] Duke NUS Grad Med Sch, Oncol Acad Clin Program, Singapore 169610, Singapore.
[Eng, Charis] Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44195 USA.
[Eng, Charis] Case Western Reserve Univ, CASE Comprehens Canc Ctr, Cleveland, OH 44106 USA.
[Eng, Charis] Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA.
RP Eng, C (reprint author), Cleveland Clin, Genom Med Inst, 9500 Euclid Ave,NE-50, Cleveland, OH 44106 USA.
EM engc@ccf.org
RI ahmed, Jamila/E-8653-2015
FU American Cancer Society; Breast Cancer Research Foundation; US
Department of Defense Breast Cancer Research Program; Doris Duke
Charitable Trust; William Randolph Hearst Foundation; Susan G. Komen for
the Cure; Ambrose Monell Foundation; National Cancer Institute; National
Institutes of Health; F.M. Kirby Foundation
FX We apologize to authors whose works or relevant references were not
cited due to word limitations. American Cancer Society, Breast Cancer
Research Foundation, US Department of Defense Breast Cancer Research
Program, Doris Duke Charitable Trust, William Randolph Hearst
Foundation, Susan G. Komen for the Cure, Ambrose Monell Foundation,
National Cancer Institute and National Institutes of Health are
gratefully acknowledged for funding C.E.'s patient-oriented research
over the last 16 years. C.E. is the Sondra J. and Stephen R. Hardis
Chair of Cancer Genomic Medicine at the Cleveland Clinic and is an
American Cancer Society Clinical Research Professor, generously funded
in part, by the F.M. Kirby Foundation.
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NR 64
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1046-2023
EI 1095-9130
J9 METHODS
JI Methods
PD MAY 1
PY 2015
VL 77-78
BP 11
EP 19
DI 10.1016/j.ymeth.2014.10.011
PG 9
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CF9XV
UT WOS:000352922000003
PM 25461771
ER
PT J
AU Liu, J
Chin-Sang, ID
AF Liu, Jun
Chin-Sang, Ian D.
TI C-elegans as a model to study PTEN's regulation and function
SO METHODS
LA English
DT Article
DE PTEN; Tumor suppressor; DAF-18; C. elegans; Genetics
ID TUMOR-SUPPRESSOR PTEN; NEMATODE CAENORHABDITIS-ELEGANS; AUTISM SPECTRUM
DISORDERS; DAUER FORMATION; LIFE-SPAN; SIGNALING PATHWAY; AXON
REGENERATION; INSULIN-RECEPTOR; DRUG DISCOVERY; CELL-MIGRATION
AB PTEN (phosphatase and tensin homolog deleted on chromosome 10) has important roles in tumor suppression, metabolism, and development, yet its regulators, effectors, and functions are not fully understood. DAF-18 is the PTEN ortholog in Caenorhabditis elegans. DAF-18's role is highly conserved to human PTEN, and can be functionally replaced by human PTEN. Thus C. elegans provides a valuable model to study FTEN. This review assesses current and emerging methods to study DAF-18's regulators and functions in C. elegans. We propose genetic modify screens to identify genes that interact with daf-18/PTEN. These genes are potential targets for anticancer drug therapies. We also provide a review on the roles DAF-18/PTEN has during C. elegans development and how studying these physiological roles can provide mechanistic insight on DAF-18/PTEN function. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Liu, Jun; Chin-Sang, Ian D.] Queens Univ, Dept Biol, Kingston, ON K7L 3N6, Canada.
RP Chin-Sang, ID (reprint author), Queens Univ, Dept Biol, 116 Barrie St, Kingston, ON K7L 3N6, Canada.
EM jun.liu@queensu.ca; chinsang@queensu.ca
FU Natural Sciences and Engineering Research Council of Canada; Canadian
Institutes for Health Research
FX The work in the Chin-Sang lab is supported by grants from the Natural
Sciences and Engineering Research Council of Canada and the Canadian
Institutes for Health Research.
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NR 106
TC 1
Z9 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1046-2023
EI 1095-9130
J9 METHODS
JI Methods
PD MAY 1
PY 2015
VL 77-78
BP 180
EP 190
DI 10.1016/j.ymeth.2014.12.009
PG 11
WC Biochemical Research Methods; Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CF9XV
UT WOS:000352922000024
PM 25514044
ER
PT J
AU Chen, HH
Kelly, C
Castellanos, FX
He, Y
Zuo, XN
Reiss, PT
AF Chen, Huaihou
Kelly, Clare
Castellanos, F. Xavier
He, Ye
Zuo, Xi-Nian
Reiss, Philip T.
TI Quantile rank maps: A new tool for understanding individual brain
development
SO NEUROIMAGE
LA English
DT Article
DE Box-Cox transformation; Generalized additive models for location; scale
and shape; Quantile rank map; MRI; Resting-state fMRI; Penalized
B-splines
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; RESTING-STATE FMRI; CORTICAL
THICKNESS; ALZHEIMERS-DISEASE; CHILDHOOD; MRI; SCHIZOPHRENIA;
TRAJECTORIES; ADOLESCENTS; MATURATION
AB We propose a novel method for neurodevelopmental brain mapping that displays how an individual's values for a quantity of interest compare with age-specific norms. By estimating smoothly age-varying distributions at a set of brain regions of interest, we derive age-dependent region-wise quantile ranks for a given individual, which can be presented in the form of a brain map. Such quantile rank maps could potentially be used for clinical screening. Bootstrap-based confidence intervals are proposed for the quantile rank estimates. We also propose a recalibrated Kolmogorov-Smirnov test for detecting group differences in the age-varying distribution. This test is shown to be more robust to model misspecification than a linear regression-based test. The proposed methods are applied to brain imaging data from the Nathan Kline Institute Rockland Sample and from the Autism Brain Imaging Data Exchange (ABIDE) sample. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Chen, Huaihou] Univ Florida, Coll Med, Coll Publ Hlth & Hlth Profess, Dept Biostat, Gainesville, FL USA.
[Kelly, Clare; Castellanos, F. Xavier; Reiss, Philip T.] NYU, Sch Med, Dept Child & Adolescent Psychiat, New York, NY 10016 USA.
[Castellanos, F. Xavier; Reiss, Philip T.] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
[He, Ye] Univ Chinese Acad Sci, Beijing, Peoples R China.
[He, Ye; Zuo, Xi-Nian] Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China.
[He, Ye; Zuo, Xi-Nian] Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China.
[He, Ye; Zuo, Xi-Nian] Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Beijing 100101, Peoples R China.
[Reiss, Philip T.] NYU, Sch Med, Dept Populat Hlth, New York, NY USA.
RP Reiss, PT (reprint author), NYU, Sch Med, Dept Child & Adolescent Psychiat, 1 Pk Ave,7th Floor, New York, NY 10016 USA.
EM phil.reiss@nyumc.org
RI ahmed, Jamila/E-8653-2015
FU National Institutes of Health [1R01MH095836-01A1, R33MH086952]; Hundred
Talents Program and the Key Research Program of the Chinese Academy of
Sciences [KSZD-EW-TZ-002]; Major Joint Fund for International
Cooperation and Exchange of the National Natural Science Foundation of
China [81220108014]
FX The authors thank Adriana Di Martino and Chao-Gan Yan for preparing the
ABIDE fMRI data. The work of Philip Reiss, Clare Kelly and Huaihou Chen
is supported by National Institutes of Health grant 1R01MH095836-01A1.
Clare Kelly and F. Xavier Castellanos are supported by National
Institutes of Health grant R33MH086952. Xi-Nian Zuo acknowledges the
Hundred Talents Program and the Key Research Program (KSZD-EW-TZ-002) of
the Chinese Academy of Sciences, and the Major Joint Fund for
International Cooperation and Exchange of the National Natural Science
Foundation of China (81220108014, XNZ).
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Xu T., 2015, SCI B IN PRESS
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NR 44
TC 0
Z9 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
EI 1095-9572
J9 NEUROIMAGE
JI Neuroimage
PD MAY 1
PY 2015
VL 111
BP 454
EP 463
DI 10.1016/j.neuroimage.2014.12.082
PG 10
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA CF0HO
UT WOS:000352224100040
PM 25585020
ER
PT J
AU Grissom, NM
Herdt, CT
Desilets, J
Lidsky-Everson, J
Reyes, TM
AF Grissom, Nicola M.
Herdt, Christopher T.
Desilets, Jeffery
Lidsky-Everson, Jordan
Reyes, Teresa M.
TI Dissociable Deficits of Executive Function Caused by Gestational
Adversity are Linked to Specific Transcriptional Changes in the
Prefrontal Cortex
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
ID VISUOSPATIAL ATTENTION; PERFORMANCE; RATS; IMPULSIVITY; EXPRESSION;
TASK; ADHD; SCHIZOPHRENIA; RESTRICTION; DISORDERS
AB Poor-quality maternal diet during pregnancy, and subsequent gestational growth disturbances in the offspring, have been implicated in the etiology of multiple neurodevelopmental disorders, including ADHD, schizophrenia, and autism. These disorders are characterized, in part, by abnormalities in responses to reward and errors of executive function. Here, we demonstrate dissociable deficits in reward processing and executive function in male and female mice, solely due to maternal malnutrition via high-fat or low-protein diets. Gestational exposure to a high-fat diet delayed acquisition of a fixed ratio response, and decreased motivation as assessed by progressive ratio. In contrast, offspring of a low-protein diet displayed no deficits in operant learning, but were more prone to assign salience to a cue that predicts reward (sign-tracking) in a Pavlovian-conditioned approach task. In the 5-choice serial reaction time task (5-CSRTT), gestational exposure to a high-fat diet promoted impulsivity, whereas exposure to a low-protein diet led to marked inattention. These dissociable executive function deficits are known to be mediated by the medial prefrontal cortex (PFC), which displays markers of epigenetic dysregulation in neurodevelopmental disorders. Following behavioral characterization, we assayed PFC gene expression using a targeted PCR array and found that both maternal diets increased overall transcription in PFC. Cluster analysis of the relationships between individual transcripts and behavioral outcomes revealed a cluster of primarily epigenetic modulators, whose overexpression was linked to executive function deficits. The overexpression of four genes, DNA methyltransferase 1 (DNMT1), delta-opioid receptor (OPRD1), cannabinoid receptor 1 (CNR1), and catechol-o-methyltransferase (COMT), was strongly associated with overall poor performance. All 5-CSRTT deficits were associated with DNMT1 upregulation, whereas impulsive behavior could be dissociated from inattention by overexpression of OPRD1 or COMT, respectively, as well as a distinct cluster of epigenetic regulators. These data provide molecular support for dissociable domains of executive function.
C1 [Grissom, Nicola M.; Herdt, Christopher T.; Desilets, Jeffery; Lidsky-Everson, Jordan; Reyes, Teresa M.] Univ Penn, Inst Translat Med & Therapeut, Perelman Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA.
RP Reyes, TM (reprint author), Univ Penn, Inst Translat Med & Therapeut, Perelman Sch Med, Dept Pharmacol, 10-131 Smilow Ctr Translat Res,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
EM reyestm@mail.med.upenn.edu
FU [MH087978]; [MH091372]
FX This work was supported by MH087978 and MH091372 to TMR. The authors
declare no conflict of interest.
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NR 49
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD MAY
PY 2015
VL 40
IS 6
BP 1353
EP 1363
DI 10.1038/npp.2014.313
PG 11
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CG0PI
UT WOS:000352968100006
PM 25418810
ER
PT J
AU van den Berg, WE
Lamballais, S
Kushner, SA
AF van den Berg, Wouter E.
Lamballais, Sander
Kushner, Steven A.
TI Sex-Specific Mechanism of Social Hierarchy in Mice
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
ID MALE-BRAIN THEORY; MOUSE-BRAIN; FACTOR SRY; AUTISM; DOMINANCE;
TESTOSTERONE; BEHAVIOR; EXPERIENCE; PREVALENCE; DYNAMICS
AB The establishment of social hierarchies is a naturally occurring, evolutionarily conserved phenomenon with a well-established impact on fitness and health. Investigations of complex social group dynamics may offer novel opportunities for translational studies of autism spectrum disorder. Here we describe a robust behavioral paradigm using an automated version of the tube test. Isogenic groups of male and female mice establish linear social hierarchies that remain highly stable for at least 14 days, the longest interval tested. Remarkably, however, their social strategy is sex-specific: females primarily utilize intrinsic attributes, whereas males are strongly influenced by prior social experience. Using both genetic and pharmacological manipulations, we identify testosterone as a critical sex-specific factor for determining which social strategy is used. Males inheriting a null mutation of the sex-determining region Y (Sry) gene used a similar social cognitive strategy as females. In contrast, females with transgenic expression of Sry utilized a typically male social strategy. Analogously, castration of males and testosterone supplementation of females yielded similar outcomes, with a reversal of their social cognitive strategy. Together, our results demonstrate a sex-specific mechanism underlying social hierarchy, in which both males and females retain the functional capacity to adapt their social strategy. More generally, we expect the automated tube test to provide an important complementary approach for both fundamental and translational studies of social behavior.
C1 [van den Berg, Wouter E.; Lamballais, Sander; Kushner, Steven A.] Erasmus Univ, Med Ctr, Dept Psychiat, NL-3015 GE Rotterdam, Netherlands.
RP Kushner, SA (reprint author), Erasmus Univ, Med Ctr, Dept Psychiat, Dr Molewaterpl 50,Ee 1442, NL-3015 GE Rotterdam, Netherlands.
EM s.kushner@erasmusmc.nl
FU Netherlands Organization for Scientific Research [ZonMw Vidi
017.106.384]; NeuroBasic-PharmaPhenomics consortium
FX This work was supported by funding from the Netherlands Organization for
Scientific Research (ZonMw Vidi 017.106.384) and the
NeuroBasic-PharmaPhenomics consortium to S.A.K. The authors declare no
conflict of interest.
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NR 50
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD MAY
PY 2015
VL 40
IS 6
BP 1364
EP 1372
DI 10.1038/npp.2014.319
PG 9
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CG0PI
UT WOS:000352968100007
PM 25469681
ER
PT J
AU Mezzelani, A
Landini, M
Facchiano, F
Raggi, ME
Villa, L
Molteni, M
De Santis, B
Brera, C
Caroli, AM
Milanesi, L
Marabotti, A
AF Mezzelani, Alessandra
Landini, Martina
Facchiano, Francesco
Raggi, Maria Elisabetta
Villa, Laura
Molteni, Massimo
De Santis, Barbara
Brera, Carlo
Caroli, Anna Maria
Milanesi, Luciano
Marabotti, Anna
TI Environment, dysbiosis, immunity and sex-specific susceptibility: A
translational hypothesis for regressive autism pathogenesis
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Review
DE Environmental autism; Gut dysbiosis; Immune system; Sex bias;
Xenobiotics
ID HUMAN GUT MICROBIOTA; NF-KAPPA-B; INCREASED URINARY-EXCRETION; VISUAL
CORTICAL PLASTICITY; SPECTRUM DISORDERS; PERIAQUEDUCTAL GRAY;
OCHRATOXIN-A; INTESTINAL MICROBIOTA; GENE-EXPRESSION; CELIAC-DISEASE
AB Background: Autism is an increasing neurodevelopmental disease that appears by 3 years of age, has genetic and/or environmental etiology, and often shows comorbid situations, such as gastrointestinal (GI) disorders. Autism has also a striking sex-bias, not fully genetically explainable.
Objective: Our goal was to explain how and in which predisposing conditions some compounds can impair neurodevelopment, why this occurs in the first years of age, and, primarily, why more in males than females.
Methods: We reviewed articles regarding the genetic and environmental etiology of autism and toxins effects on animal models selected from PubMed and databases about autism and toxicology.
Discussion: Our hypothesis proposes that in the first year of life, the decreasing of maternal immune protection and child immune-system immaturity create an immune vulnerability to infection diseases that, especially if treated with antibiotics, could facilitate dysbiosis and GI disorders. This condition triggers a vicious circle between immune system impairment and increasing dysbiosis that leads to leaky gut and neurochemical compounds and/or neurotoxic xenobiotics production and absorption. This alteration affects the 'gut-brain axis' communication that connects gut with central nervous system via immune system. Thus, metabolic pathways impaired in autistic children can be affected by genetic alterations or by environment-xenobiotics interference. In addition, in animal models many xenobiotics exert their neurotoxicity in a sex-dependent manner.
Conclusions: We integrate fragmented and multi-disciplinary information in a unique hypothesis and first disclose a possible environmental origin for the imbalance of male: female distribution of autism, reinforcing the idea that exogenous factors are related to the recent rise of this disease.
C1 [Mezzelani, Alessandra; Landini, Martina; Milanesi, Luciano] CNR, Inst Biomed Technol, I-20090 Segrate, MI, Italy.
[Facchiano, Francesco; De Santis, Barbara; Brera, Carlo] Ist Super Sanita, I-00161 Rome, Italy.
[Raggi, Maria Elisabetta; Villa, Laura; Molteni, Massimo; Marabotti, Anna] IRCCS E Medea Ass La Nostra Famiglia, I-23842 Bosisio Parini, LC, Italy.
[Caroli, Anna Maria] Univ Brescia, Dept Sci Biomed & Biotecnol, I-25123 Brescia, BS, Italy.
RP Mezzelani, A (reprint author), CNR, Inst Biomed Technol, I-20133 Milan, Segrate, Italy.
EM alessandra.mezzelani@itb.cnr.it
FU Italian Ministry of Health [GR-2009-1570296]; Italian Ministry of
Education and Research (MIUR) [PB05, RBPR05ZK2Z, RBAP11YS7K]
FX This work has been supported by the Italian Ministry of Health (Targeted
Research Funding in Public Health - Young Researchers) GR-2009-1570296.
A.M., M.L., and L.M. are supported also by the Italian Ministry of
Education and Research (MIUR) through the Flagship project InterOmics
(PB05), FIRB ITALBIONET (RBPR05ZK2Z), and HIRMA RBAP11YS7K.
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NR 167
TC 0
Z9 0
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD MAY
PY 2015
VL 18
IS 4
BP 145
EP 161
DI 10.1179/1476830513Y.0000000108
PG 17
WC Neurosciences; Nutrition & Dietetics
SC Neurosciences & Neurology; Nutrition & Dietetics
GA CF9MQ
UT WOS:000352889200001
PM 24621061
ER
PT J
AU Navarro, F
Pearson, DA
Fatheree, N
Mansour, R
Hashmi, SS
Rhoads, JM
AF Navarro, Fernando
Pearson, Deborah A.
Fatheree, Nicole
Mansour, Rosleen
Hashmi, S. Shahrukh
Rhoads, J. Marc
TI Are 'leaky gut' and behavior associated with gluten and dairy containing
diet in children with autism spectrum disorders?
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Autism spectrum disorder (ASD); Diet; Gluten; Dairy; Behavior;
Intestinal permeability
ID ABNORMAL INTESTINAL PERMEABILITY; CASEIN-FREE DIET; CELIAC-DISEASE;
DOUBLE-BLIND; INTERVENTION; RELIABILITY; VALIDITY; DIARRHEA; ALLERGY;
AGE
AB Objectives: Studies have suggested a link between diet and behavior in children with autism spectrum disorders (ASDs). Parental reports of behavioral changes upon exposure to gluten and/or casein are common in clinical practice. An association between diet type, intestinal permeability (IP) ('leaky gut'), and behavior has been long proposed but not substantiated. We explored this possible association in this trial.
Methods: This randomized double-blind, placebo-controlled study explored the effects of gluten and milk on IP and behavior in children with ASDs over a period of 4 weeks. IP assessed by lactulose: mannitol (L/M) sugar permeability test and behavior assessed by the Aberrant Behavior Checklist and Conners Parent Rating were measured. Gastrointestinal symptoms in both groups were also monitored.
Results: Neither the L/M ratio nor behavioral scores were different between groups exposed to gluten/dairy or placebo. The changes observed were noted to be small and not clinically significant. Discussion: Our study although underpowered to show small differences does not support an association between dietary gluten/milk, IP, and behavioral changes in subjects with ASD.
C1 [Navarro, Fernando; Fatheree, Nicole; Hashmi, S. Shahrukh; Rhoads, J. Marc] Univ Texas Houston, Sch Med, Dept Pediat, Houston, TX 77030 USA.
[Pearson, Deborah A.; Mansour, Rosleen] Univ Texas Houston, Sch Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
RP Navarro, F (reprint author), Univ Texas Houston, Sch Med, Dept Pediat, Sect Gastroenterol Hepatol & Nutr, 6431 Fannin,Room 3-140, Houston, TX 77030 USA.
EM Fernando.Navarro@uth.tmc.edu
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NR 37
TC 0
Z9 0
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD MAY
PY 2015
VL 18
IS 4
BP 177
EP 185
DI 10.1179/1476830514Y.0000000110
PG 9
WC Neurosciences; Nutrition & Dietetics
SC Neurosciences & Neurology; Nutrition & Dietetics
GA CF9MQ
UT WOS:000352889200004
PM 24564346
ER
PT J
AU Kohl, C
Wang, XD
Grosse, J
Fournier, C
Harbich, D
Westerholz, S
Li, JT
Bacq, A
Sippel, C
Hausch, F
Sandi, C
Schmidt, MV
AF Kohl, Christine
Wang, Xiao-Dong
Grosse, Jocelyn
Fournier, Celine
Harbich, Daniela
Westerholz, Soeren
Li, Ji-Tao
Bacq, Alexandre
Sippel, Claudia
Hausch, Felix
Sandi, Carmen
Schmidt, Mathias V.
TI Hippocampal neuroligin-2 links early-life stress with impaired social
recognition and increased aggression in adult mice
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Cell adhesion molecule; Neuroligin-2; Early life stress; Hippocampus;
Social behavior; Aggression
ID CELL-ADHESION MOLECULES; INHIBITORY SYNAPSES; SYNAPTIC FUNCTION;
SCHIZOPHRENIA; NEUREXINS; BEHAVIOR; CHILDHOOD; DISORDER; VIOLENCE; GENE
AB Early-life stress is a key risk factor for the development of neuropsychiatric disorders later in life. Neuronal cell adhesion molecules have been strongly implicated in the pathophysiology of psychiatric disorders and in modulating social behaviors associated with these diseases. Neuroligin-2 is a synaptic cell adhesion molecule, located at the postsynaptic membrane of inhibitory GABAergic synapses, and is involved in synaptic stabilization and maturation. Alterations in neuroligin-2 expression have previously been associated with changes in social behavior linked to psychiatric disorders, including schizophrenia and autism. In this study, we show that early-life stress, induced by limited nesting and bedding material, leads to impaired social recognition and increased aggression in adult mice, accompanied by increased expression levels of hippocampal neuroligin-2. Viral overexpression of hippocampal neuroligin-2 in adulthood mimics early-life stress-induced alterations in social behavior and social cognition. Moreover, viral knockdown of neuroligin-2 in the adult hippocampus attenuates the early-life stress-induced behavioral changes. Our results highlight the importance of neuroligin-2 in mediating early-life stress effects on social behavior and social cognition and its promising role as a novel therapeutic target for neuropsychiatric disorders. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Kohl, Christine; Grosse, Jocelyn; Fournier, Celine; Bacq, Alexandre; Sandi, Carmen] Ecole Polytech Fed Lausanne, Sch Life Sci, Brain Mind Inst, Lab Behav Genet, CH-1015 Lausanne, Switzerland.
[Kohl, Christine; Wang, Xiao-Dong; Harbich, Daniela; Westerholz, Soeren; Sippel, Claudia; Hausch, Felix; Schmidt, Mathias V.] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich, Germany.
[Wang, Xiao-Dong] Zhejiang Univ, Sch Med, Zhejiang Prov Key Lab Neurobiol, Dept Neurobiol,Key Lab Med Neurobiol,Minist Hlth, Hangzhou 310058, Zhejiang, Peoples R China.
[Li, Ji-Tao] Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China.
RP Schmidt, MV (reprint author), Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Kraepelinstr 2-10, D-80804 Munich, Germany.
EM mschmidt@mpipsykl.mpg.de
RI ahmed, Jamila/E-8653-2015
FU European Union from the Swiss National Science Foundation
[FP7-HEALTH-F2M-2007-201600, 31003AB-135710, 31003A-152614]; Oak
Foundation; EPFL
FX This work was supported by the European Union integrated project
MEMSTICK (FP7-HEALTH-F2M-2007-201600; MemStick) grants from the Swiss
National Science Foundation (31003AB-135710, 31003A-152614, and the NCCR
Synapsy), Oak Foundation, and intramural funding from the EPFL.
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NR 56
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2015
VL 55
BP 128
EP 143
DI 10.1016/j.psyneuen.2015.02.016
PG 16
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CG2FK
UT WOS:000353090100012
PM 25765754
ER
PT J
AU Buxbaum, JD
AF Buxbaum, Joseph D.
TI DSM-5 and Psychiatric Genetics - Round Hole, Meet Square Peg
SO BIOLOGICAL PSYCHIATRY
LA English
DT Editorial Material
ID AUTISM; MUTATIONS; GENES; RISK
C1 [Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, Friedman Brain Inst, Dept Psychiat, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, Friedman Brain Inst, Dept Neurosci, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, Friedman Brain Inst, Dept Genet, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, Friedman Brain Inst, Dept Genom Sci, New York, NY 10029 USA.
[Buxbaum, Joseph D.] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
RP Buxbaum, JD (reprint author), Icahn Sch Med Mt Sinai, Dept Psychiat, One Gustave Levy Pl,Box 1668, New York, NY 10029 USA.
EM joseph.buxbaum@mssm.edu
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TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 766
EP 768
PG 3
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800001
PM 25843333
ER
PT J
AU Duyzend, MH
Eichler, EE
AF Duyzend, Michael H.
Eichler, Evan E.
TI Genotype-First Analysis of the 16p11.2 Deletion Defines a New Type of
"Autism"
SO BIOLOGICAL PSYCHIATRY
LA English
DT Editorial Material
C1 [Duyzend, Michael H.; Eichler, Evan E.] Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA.
[Eichler, Evan E.] Univ Washington, Sch Med, Howard Hughes Med Inst, Seattle, WA 98195 USA.
RP Eichler, EE (reprint author), Univ Washington, Sch Med, Howard Hughes Med Inst, Foege S413C,3720 15th Ave NE,Box 355065, Seattle, WA 98195 USA.
EM eee@gs.washington.edu
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NR 10
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 769
EP 771
PG 3
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800002
PM 25843334
ER
PT J
AU McPartland, JC
Jeste, SS
AF McPartland, James C.
Jeste, Shafali S.
TI Connectivity in Context: Emphasizing Neurodevelopment in Autism Spectrum
Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Editorial Material
C1 [McPartland, James C.] Yale Child Study Ctr, New Haven, CT 06520 USA.
[Jeste, Shafali S.] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Autism Res & Treatment, Los Angeles, CA 90095 USA.
RP McPartland, JC (reprint author), Yale Child Study Ctr, 230 South Frontage Rd, New Haven, CT 06520 USA.
EM james.mcpartland@yale.edu
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NR 10
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 772
EP 774
PG 3
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800003
PM 25843335
ER
PT J
AU Chaste, P
Klei, L
Sanders, SJ
Hus, V
Murtha, MT
Lowe, JK
Willsey, AJ
Moreno-De-Luca, D
Yu, TW
Fombonne, E
Geschwind, D
Grice, DE
Ledbetter, DH
Mane, SM
Martin, DM
Morrow, EM
Walsh, CA
Sutcliffe, JS
Martin, CL
Beaudet, AL
Lord, C
State, MW
Cook, EH
Devlin, B
AF Chaste, Pauline
Klei, Lambertus
Sanders, Stephan J.
Hus, Vanessa
Murtha, Michael T.
Lowe, Jennifer K.
Willsey, A. Jeremy
Moreno-De-Luca, Daniel
Yu, Timothy W.
Fombonne, Eric
Geschwind, Daniel
Grice, Dorothy E.
Ledbetter, David H.
Mane, Shrikant M.
Martin, Donna M.
Morrow, Eric M.
Walsh, Christopher A.
Sutcliffe, James S.
Martin, Christa Lese
Beaudet, Arthur L.
Lord, Catherine
State, Matthew W.
Cook, Edwin H., Jr.
Devlin, Bernie
TI A Genome-wide Association Study of Autism Using the Simons Simplex
Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase
Genetic Homogeneity?
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism; Genetics; GWAS; Heterogeneity; Phenotype; Power
ID SPECTRUM DISORDERS; SUSCEPTIBILITY GENE; INTELLECTUAL DISABILITY;
LINKAGE ANALYSES; SEX-DIFFERENCES; RETT-SYNDROME; RISK LOCI; PDD-NOS;
SCHIZOPHRENIA; VARIANTS
AB BACKGROUND: Phenotypic heterogeneity in autism has long been conjectured to be a major hindrance to the discovery of genetic risk factors, leading to numerous attempts to stratify children based on phenotype to increase power of discovery studies. This approach, however, is based on the hypothesis that phenotypic heterogeneity closely maps to genetic variation, which has not been tested. Our study examines the impact of subphenotyping of a well-characterized autism spectrum disorder (ASD) sample on genetic homogeneity and the ability to discover common genetic variants conferring liability to ASD.
METHODS: Genome-wide genotypic data of 2576 families from the Simons Simplex Collection were analyzed in the overall sample and phenotypic subgroups defined on the basis of diagnosis, IQ, and symptom profiles. We conducted a family-based association study, as well as estimating heritability and evaluating allele scores for each phenotypic subgroup.
RESULTS: Association analyses revealed no genome-wide significant association signal. Subphenotyping did not increase power substantially. Moreover, allele scores built from the most associated single nucleotide polymorphisms, based on the odds ratio in the full sample, predicted case status in subsets of the sample equally well and heritability estimates were very similar for all subgroups.
CONCLUSIONS: In genome-wide association analysis of the Simons Simplex Collection sample, reducing phenotypic heterogeneity had at most a modest impact on genetic homogeneity. Our results are based on a relatively small sample, one with greater homogeneity than the entire population; if they apply more broadly, they imply that analysis of subphenotypes is not a productive path forward for discovering genetic risk variants in ASD.
C1 [Chaste, Pauline; Klei, Lambertus; Devlin, Bernie] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
[Chaste, Pauline] FondaMental Fdn, Paris, France.
[Chaste, Pauline] Ctr Hosp St Anne, F-75014 Paris, France.
[Sanders, Stephan J.; Willsey, A. Jeremy; State, Matthew W.] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA.
[Sanders, Stephan J.; Willsey, A. Jeremy; State, Matthew W.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
[Hus, Vanessa] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
[Murtha, Michael T.; Moreno-De-Luca, Daniel] Yale Univ, Sch Med, Program Neurogenet, New Haven, CT 06510 USA.
[Lowe, Jennifer K.; Geschwind, Daniel] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst, Dept Neurol,Neurogenet Program, Los Angeles, CA 90095 USA.
[Lowe, Jennifer K.; Geschwind, Daniel] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Autism Res & Treatment, Semel Inst, Los Angeles, CA 90095 USA.
[Martin, Donna M.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA.
[Yu, Timothy W.] Harvard Univ, Childrens Hosp Boston, Sch Med, Div Genet, Boston, MA 02115 USA.
[Fombonne, Eric] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97201 USA.
[Fombonne, Eric] Oregon Hlth & Sci Univ, Inst Dev & Disabil, Portland, OR 97201 USA.
[Grice, Dorothy E.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
[Ledbetter, David H.; Martin, Christa Lese] Geisinger Hlth Syst, Autism & Dev Med Inst, Danville, PA USA.
[Mane, Shrikant M.] Yale Ctr Genome Anal, Orange, CT USA.
[Martin, Donna M.] Univ Michigan, Med Ctr, Dept Pediat, Ann Arbor, MI 48109 USA.
[Martin, Donna M.] Univ Michigan, Med Ctr, Dept Human Genet, Ann Arbor, MI 48109 USA.
[Morrow, Eric M.] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA.
[Morrow, Eric M.] Brown Univ, Dept Psychiat & Human Behav, Providence, RI 02912 USA.
[Walsh, Christopher A.] Harvard Univ, Sch Med, Ctr Life Sci, Howard Hughes Med Inst, Boston, MA 02115 USA.
[Walsh, Christopher A.] Harvard Univ, Childrens Hosp Boston, Ctr Life Sci, Sch Med,Div Genet, Boston, MA 02115 USA.
[Walsh, Christopher A.] Harvard Univ, Sch Med, Ctr Life Sci, Neurol & Pediat, Boston, MA 02115 USA.
[Sutcliffe, James S.] Vanderbilt Univ, Vanderbilt Brain Inst, Dept Mol Physiol, Nashville, TN 37235 USA.
[Sutcliffe, James S.] Vanderbilt Univ, Vanderbilt Brain Inst, Dept Biophys & Psychiat, Nashville, TN 37235 USA.
[Beaudet, Arthur L.] Baylor Coll Med, Dept Human & Mol Genet, Houston, TX 77030 USA.
[Lord, Catherine] Weill Cornell Med Coll, Ctr Autism & Developing Brain, White Plains, NY USA.
[Cook, Edwin H., Jr.] Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60612 USA.
RP Chaste, P (reprint author), Ctr Hosp St Anne, 1 Rue Cabanis, F-75014 Paris, France.
EM p.chaste@ch-sainte-anne.fr
RI Sutcliffe, James/C-1348-2012
OI Sutcliffe, James/0000-0001-5200-6007
FU Simons Foundation [SFARI 124827]; National Institutes of Health (NIH)
[R01HD065272, R01MH089390, R37 MH057881]; National Institute of Mental
Health Malison [5R25MH071584-07, 5 T32 MH19961-14]; FondaMental
Foundation
FX This work was supported by a grant from the Simons Foundation (SFARI
124827 to the investigators of the Simons Simplex Collection [SSC]
Genetic Consortium); National Institutes of Health (NIH) R01HD065272
(CL), NIH R01MH089390 (CL), NIH R37 MH057881 (BD), National Institute of
Mental Health 5R25MH071584-07 Malison (DM-D-L), National Institute of
Mental Health 5 T32 MH19961-14 Malison (DM-D-L), and the FondaMental
Foundation (PC).
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NR 72
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 775
EP 784
DI 10.1016/j.biopsych.2014.09.017
PG 10
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800004
PM 25534755
ER
PT J
AU Hanson, E
Bernier, R
Porche, K
Jackson, FI
Goin-Kochel, RP
Snyder, LG
Snow, AV
Wallace, AS
Campe, KL
Zhang, Y
Chen, QX
D'Angelo, D
Moreno-De-Luca, A
Orr, PT
Boomer, KB
Evans, DW
Kanne, S
Berry, L
Miller, FK
Olson, J
Sherr, E
Martin, CL
Ledbetter, DH
Spiro, JE
Chung, WK
AF Hanson, Ellen
Bernier, Raphael
Porche, Ken
Jackson, Frank I.
Goin-Kochel, Robin P.
Snyder, LeeAnne Green
Snow, Anne V.
Wallace, Arianne Stevens
Campe, Katherine L.
Zhang, Yuan
Chen, Qixuan
D'Angelo, Debra
Moreno-De-Luca, Andres
Orr, Patrick T.
Boomer, K. B.
Evans, David W.
Kanne, Stephen
Berry, Leandra
Miller, Fiona K.
Olson, Jennifer
Sherr, Elliot
Martin, Christa L.
Ledbetter, David H.
Spiro, John E.
Chung, Wendy K.
CA Simons Variation Individuals Proje
TI The Cognitive and Behavioral Phenotype of the 16p11.2 Deletion in a
Clinically Ascertained Population
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE 16p11.2 Deletion; Autism; Autism spectrum disorder; Developmental
disability; Genetics; Psychiatric diagnosis
ID AUTISM SPECTRUM DISORDERS; RECURRENT REARRANGEMENTS; DIAGNOSTIC
INTERVIEW; CHILDREN; ASSOCIATION; LANGUAGE; INDIVIDUALS; RELIABILITY;
IMPAIRMENT; MUTATIONS
AB BACKGROUND: Deletion of the recurrent similar to 600 kb BP4-BP5 chromosomal region 16p11.2 has been associated with a wide range of neurodevelopmental outcomes.
METHODS: To clarify the phenotype of 16p11.2 deletion, we examined the psychiatric and developmental presentation of predominantly clinically referred individuals, with a particular emphasis on broader autism phenotype characteristics in individuals with recurrent similar to 600 kb chromosome 16p11.2 deletions. Using an extensive standardized assessment battery across three clinical sites, 85 individuals with the 16p11.2 deletion and 153 familial control subjects were evaluated for symptom presentation and clinical diagnosis.
RESULTS: Individuals with the 16p11.2 deletion presented with a high frequency of psychiatric and developmental disorders (>90%). The most commonly diagnosed conditions were developmental coordination disorder, phonologic processing disorder, expressive and receptive language disorders (71% of individuals >3 years old with a speech and language-related disorder), and autism spectrum disorder. Individuals with the 16p11.2 deletion not meeting diagnostic criteria for autism spectrum disorder had a significantly higher prevalence of autism-related characteristics compared with the familial noncarrier control group. Individuals with the 16p11.2 deletion had a range of intellectual ability, but IQ scores were 26 points lower than noncarrier family members on average.
CONCLUSIONS: Clinically referred individuals with the 16p11.2 deletion have high rates of psychiatric and developmental disorders and provide a genetically well-defined group to study the emergence of developmental difficulties, particularly associated with the broader autism phenotype.
C1 [Hanson, Ellen; Porche, Ken; Jackson, Frank I.; Snyder, LeeAnne Green; Snow, Anne V.; Campe, Katherine L.; Miller, Fiona K.; Olson, Jennifer] Childrens Hosp Boston, Div Dev Med, Boston, MA 02215 USA.
[Hanson, Ellen; Snow, Anne V.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
[Bernier, Raphael; Wallace, Arianne Stevens] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
[Goin-Kochel, Robin P.; Berry, Leandra] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
[Zhang, Yuan; Chen, Qixuan; D'Angelo, Debra] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA.
[Moreno-De-Luca, Andres; Orr, Patrick T.; Evans, David W.; Martin, Christa L.; Ledbetter, David H.] Geisinger Hlth Syst, Autism & Dev Med Inst, Danville, PA USA.
[Moreno-De-Luca, Andres; Martin, Christa L.; Ledbetter, David H.] Geisinger Hlth Syst, Genom Med Inst, Danville, PA USA.
[Moreno-De-Luca, Andres] Geisinger Hlth Syst, Dept Radiol, Danville, PA USA.
[Boomer, K. B.] Bucknell Univ, Dept Math, Lewisburg, PA 17837 USA.
[Kanne, Stephen] Univ Missouri, Thompson Ctr Autism & Neurodev Disorders, Columbia, MO USA.
[Sherr, Elliot] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA.
[Spiro, John E.] Simons Fdn, New York, NY USA.
[Chung, Wendy K.] Columbia Univ, Dept Pediat, New York, NY 10027 USA.
[Chung, Wendy K.] Columbia Univ, Dept Med, New York, NY 10027 USA.
RP Hanson, E (reprint author), Childrens Hosp Boston, Div Dev Med, 1295 Boylston St,3rd Floor, Boston, MA 02215 USA.
EM ellen.hanson@chil-drens.harvard.edu
FU Simons Foundation (Simons Foundation Autism Research Initiative Grant)
[198677, 312100]; National Institutes of Health [MH074090]
FX This work was supported by two grants from the Simons Foundation (Simons
Foundation Autism Research Initiative Grant No. 198677 to EH, RB, RPG-K,
and WKC and Simons Foundation Autism Research Initiative Grant No.
312100 to CLM, and DHL) and a grant from the National Institutes of
Health (Grant No. MH074090 to DHL and CLM).
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NR 56
TC 1
Z9 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 785
EP 793
DI 10.1016/j.biopsych.2014.04.021
PG 9
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800005
PM 25064419
ER
PT J
AU Kitzbichler, MG
Khan, S
Ganesan, S
Vangel, MG
Herbert, MR
Hamalainen, MS
Kenet, T
AF Kitzbichler, Manfred G.
Khan, Sheraz
Ganesan, Santosh
Vangel, Mark G.
Herbert, Martha R.
Haemaelaeinen, Matti S.
Kenet, Tal
TI Altered Development and Multifaceted Band-Specific Abnormalities of
Resting State Networks in Autism
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism; Connectivity; Cortex; Development; MEG activity; Resting state
ID FUNCTIONAL CONNECTIVITY MRI; SPACE SEPARATION METHOD; SPECTRUM
DISORDERS; DEFAULT-MODE; HUMAN BRAIN; CORTICAL ACTIVITY; MEG
MEASUREMENTS; WORKING-MEMORY; FRONTAL-CORTEX; GAMMA
AB BACKGROUND: Extensive evidence indicates that cortical connectivity patterns are abnormal in autism spectrum disorders (ASD), showing both overconnectivity and underconnectivity. Since, however, studies to date have focused on either spatial or spectral dimensions, but not both simultaneously, much remains unknown about the nature of these abnormalities. In particular, it remains unknown whether abnormal connectivity patterns in ASD are driven by specific frequency bands, by spatial network properties, or by some combination of these factors.
METHODS: Magnetoencephalography recordings (15 ASD, 15 control subjects) mapped back onto cortical space were used to study resting state networks in ASD with both spatial and spectral specificity. The data were quantified using graph theoretic metrics.
RESULTS: The two major factors that drove the nature of connectivity abnormalities in ASD were the mediating frequency band and whether the network included frontal nodes. These factors determined whether clustering and integration were increased or decreased in cortical resting state networks in ASD. These measures also correlated with abnormalities in the developmental trajectory of resting state networks in ASD. Lastly, these measures correlated with ASD severity in some frequency bands and spatially specific subnetworks.
CONCLUSIONS: Our findings suggest that network abnormalities in ASD are widespread, are more likely in subnetworks that include the frontal lobe, and can be opposite in nature depending on the frequency band. These findings thus elucidate seemingly contradictory prior findings of both overconnectivity and underconnectivity in ASD.
C1 [Kitzbichler, Manfred G.; Khan, Sheraz; Ganesan, Santosh; Vangel, Mark G.; Herbert, Martha R.; Haemaelaeinen, Matti S.; Kenet, Tal] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA.
[Kitzbichler, Manfred G.; Khan, Sheraz; Ganesan, Santosh; Herbert, Martha R.; Kenet, Tal] Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA.
[Vangel, Mark G.; Haemaelaeinen, Matti S.] Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA 02129 USA.
RP Kenet, T (reprint author), Massachusetts Gen Hosp, 149 Thirteenth St,Room 2275, Charlestown, MA 02129 USA.
EM tal@nmr.mgh.harvard.edu
FU Nancy Lurie Marks Foundation; Nancy Lurie Marks Family Foundation;
Autism Speaks; National Center for Research Resources [P41RR14075];
National Institute for Biomedical Imaging and Bioengineering
[5R01EB009048]; Cognitive Rhythms Collaborative: A Discovery Network
[NFS 1042134]
FX We gratefully acknowledge the financial support from the Nancy Lurie
Marks Foundation without which this work would not have been possible.
Authors received research funding from the following organizations and
funding bodies: The Nancy Lurie Marks Family Foundation (TK, MGK, SK),
Autism Speaks (TK), The National Center for Research Resources
(P41RR14075, MSH), National Institute for Biomedical Imaging and
Bioengineering (5R01EB009048, MSH), and the Cognitive Rhythms
Collaborative: A Discovery Network (NFS 1042134, MSH). MGK is currently
affiliated with the Behavioural and Clinical Neuroscience Institute,
University of Cambridge, Cambridge, United Kingdom.
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NR 75
TC 2
Z9 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 794
EP 804
DI 10.1016/j.biopsych.2014.05.012
PG 11
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800006
PM 25064418
ER
PT J
AU Aceti, M
Creson, TK
Vaissiere, T
Rojas, C
Huang, WC
Wang, YX
Petralia, RS
Page, DT
Miller, CA
Rumbaugh, G
AF Aceti, Massimiliano
Creson, Thomas K.
Vaissiere, Thomas
Rojas, Camilo
Huang, Wen-Chin
Wang, Ya-Xian
Petralia, Ronald S.
Page, Damon T.
Miller, Courtney A.
Rumbaugh, Gavin
TI Syngap1 Haploinsufficiency Damages a Postnatal Critical Period of
Pyramidal Cell Structural Maturation Linked to Cortical Circuit Assembly
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorder; Development; Epilepsy; Intellectual
disability; Mouse model; Synapse; Syngap1
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; GTPASE-ACTIVATING PROTEIN;
INTELLECTUAL DISABILITY; SYNAPTIC PLASTICITY; NEUROPSYCHIATRIC
DISORDERS; MENTAL-RETARDATION; NEURONS; CORTEX; SCHIZOPHRENIA
AB BACKGROUND: Genetic haploinsufficiency of SYNGAP1/Syngap1 commonly occurs in developmental brain disorders, such as intellectual disability, epilepsy, schizophrenia, and autism spectrum disorder. Thus, studying mouse models of Syngap1 haploinsufficiency may uncover pathologic developmental processes common among distinct brain disorders.
METHODS: A Syngap1 haploinsufficiency model was used to explore the relationship between critical period dendritic spine abnormalities, cortical circuit assembly, and the window for genetic rescue to understand how damaging mutations disrupt key substrates of mouse brain development.
RESULTS: Syngap1 mutations broadly disrupted a developmentally sensitive period that corresponded to the period of heightened postnatal cortical synaptogenesis. Pathogenic Syngap1 mutations caused a coordinated acceleration of dendrite elongation and spine morphogenesis and pruning of these structures in neonatal cortical pyramidal neurons. These mutations also prevented a form of developmental structural plasticity associated with experience-dependent reorganization of brain circuits. Consistent with these findings, Syngap1 mutant mice displayed an altered pattern of long-distance synaptic inputs into a cortical area important for cognition. Interestingly, the ability to genetically improve the behavioral endophenotype of Syngap1 mice decreased slowly over postnatal development and mapped onto the developmental period of coordinated dendritic insults.
CONCLUSIONS: Pathogenic Syngap1 mutations have a profound impact on the dynamics and structural integrity of pyramidal cell postsynaptic structures known to guide the de novo wiring of nascent cortical circuits. These findings support the idea that disrupted critical periods of dendritic growth and spine plasticity may be a common pathologic process in developmental brain disorders.
C1 [Aceti, Massimiliano; Creson, Thomas K.; Vaissiere, Thomas; Rojas, Camilo; Huang, Wen-Chin; Page, Damon T.; Miller, Courtney A.; Rumbaugh, Gavin] Scripps Res Inst, Dept Neurosci, Jupiter, FL USA.
[Vaissiere, Thomas; Miller, Courtney A.] Scripps Res Inst, Dept Metab & Aging, Jupiter, FL USA.
[Wang, Ya-Xian; Petralia, Ronald S.] NIDCD, Adv Imaging Core, NIH, Bethesda, MD USA.
RP Rumbaugh, G (reprint author), Scripps Florida, 130 Scripps Way, Jupiter, FL 33458 USA.
EM grumbaug@scripps.edu
FU National Institute for Neurological Disorders and Stroke [R01NS064079];
National Institute for Mental Health [R01MH096847]; National Institute
for Drug Abuse [R01 DA034116, R03 DA033499]; National Institute on
Deafness and Other Communication Disorders/National Institutes of Health
Intramural Research Program; State of Florida
FX This work was supported by grants to GR from The National Institute for
Neurological Disorders and Stroke (R01NS064079) andThe National
Institute for Mental Health (R01MH096847). CAM was supported by grants
from the National Institute for Drug Abuse (R01 DA034116; R03 DA033499).
Y-XW and RSP were supported by the National Institute on Deafness and
Other Communication Disorders/National Institutes of Health Intramural
Research Program. W-CH and DTP were supported by gift funds from Mrs.
Nancy Lurie Marks. GR, CAM, and DTP were supported by the State of
Florida.
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NR 43
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 805
EP 815
DI 10.1016/j.biopsych.2014.08.001
PG 11
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800007
PM 25444158
ER
PT J
AU Pinggera, A
Lieb, A
Benedetti, B
Lampert, M
Monteleone, S
Liedl, KR
Tuluc, P
Striessnig, J
AF Pinggera, Alexandra
Lieb, Andreas
Benedetti, Bruno
Lampert, Michaela
Monteleone, Stefania
Liedl, Klaus R.
Tuluc, Petronel
Striessnig, Joerg
TI CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3
L-Type Calcium Channels
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorders; Calcium channel blockers; Human genetics;
L-type calcium channels; Neuropsychiatric disorders; Whole-exome
sequencing
ID GATED CA2+ CHANNELS; CONGENITAL DEAFNESS; PACEMAKER ACTIVITY; CA(V)1.3;
MICE; SCHIZOPHRENIA; DYSFUNCTION; ELIMINATION; DEPENDENCE; SYNAPSES
AB BACKGROUND: Cav1.3 voltage-gated L-type calcium channels (LTCCs) are part of postsynaptic neuronal signaling networks. They play a key role in brain function, including fear memory and emotional and drug-taking behaviors. A whole-exome sequencing study identified a de novo mutation, p.A749G, in Cav1.3 alpha(1)-subunits (CACNA1D), the second main LTCC in the brain, as 1 of 62 high risk-conferring mutations in a cohort of patients with autism and intellectual disability. We screened all published genetic information available from whole-exome sequencing studies and identified a second de novo CACNA1D mutation, p.G407R. Both mutations are present only in the probands and not in their unaffected parents or siblings.
METHODS: We functionally expressed both mutations in tsA-201 cells to study their functional consequences using whole-cell patch-clamp.
RESULTS: The mutations p.A749G and p.G407R caused dramatic changes in channel gating by shifting (similar to 15 mV) the voltage dependence for steady-state activation and inactivation to more negative voltages (p.A749G) or by pronounced slowing of current inactivation during depolarizing stimuli (p.G407R). In both cases, these changes are compatible with a gain-of-function phenotype.
CONCLUSIONS: Our data, together with the discovery that Cav1.3 gain-of-function causes primary aldosteronism with seizures, neurologic abnormalities, and intellectual disability, suggest that Cav1.3 gain-of-function mutations confer a major part of the risk for autism in the two probands and may even cause the disease. Our findings have immediate clinical relevance because blockers of LTCCs are available for therapeutic attempts in affected individuals. Patients should also be explored for other symptoms likely resulting from Cav1.3 hyperactivity, in particular, primary aldosteronism.
C1 [Pinggera, Alexandra; Lieb, Andreas; Benedetti, Bruno; Lampert, Michaela; Tuluc, Petronel; Striessnig, Joerg] Univ Innsbruck, Ctr Mol Biosci, Dept Pharmacol & Toxicol, A-6020 Innsbruck, Austria.
[Monteleone, Stefania; Liedl, Klaus R.] Univ Innsbruck, Ctr Mol Biosci, Inst Gen Inorgan & Theoret Chem, A-6020 Innsbruck, Austria.
RP Striessnig, J (reprint author), Univ Innsbruck, Ctr Mol Biosci, Pharmacol & Toxicol, Innrain 80-82, A-6020 Innsbruck, Austria.
EM joerg.striessnig@uibk.ac.at
RI Liedl, Klaus/F-3099-2015
OI Liedl, Klaus/0000-0002-0985-2299
FU Austrian Science Fund [F44020, W11]; University of Innsbruck
FX This work was supported by the Austrian Science Fund Grant Nos. F44020
and W11 and the University of Innsbruck.
CR An JY, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.38
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NR 44
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 816
EP 822
DI 10.1016/j.biopsych.2014.11.020
PG 7
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800008
PM 25620733
ER
PT J
AU Machado, CJ
Whitaker, AM
Smith, SEP
Patterson, PH
Bauman, MD
AF Machado, Christopher J.
Whitaker, Alexander M.
Smith, Stephen E. P.
Patterson, Paul H.
Bauman, Melissa D.
TI Maternal Immune Activation in Nonhuman Primates Alters Social Attention
in Juvenile Offspring
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism spectrum disorders; Immunology; Macaque; Nonhuman primate; Poly
IC; Schizophrenia; Social attention
ID AUTISM SPECTRUM DISORDERS; HIGH-FUNCTIONING AUTISM; ULTRA-HIGH RISK;
FACIAL EXPRESSIONS; PRENATAL STRESS; AMYGDALA DAMAGE; IN-UTERO;
NEURODEVELOPMENTAL DISORDERS; IMPAIRED RECOGNITION; 1ST-DEGREE RELATIVES
AB BACKGROUND: Sickness during pregnancy is associated with an increased risk of offspring neurodevelopmental disorders. Rodent models have played a critical role in establishing causal relationships and identifying mechanisms of altered brain and behavior development in pups prenatally exposed to maternal immune activation (MIA). We recently developed a novel nonhuman primate model to bridge the gap between human epidemiological studies and rodent models of prenatal immune challenge. Our initial results demonstrated that rhesus monkeys given the viral mimic synthetic double-stranded RNA (polyinosinic: polycytidylic acid stabilized with poly-l-lysine) during pregnancy produce offspring with abnormal repetitive behaviors, altered communication, and atypical social interactions.
METHODS: We utilized noninvasive infrared eye tracking to further evaluate social processing capabilities in a subset of the first trimester MIA-exposed offspring (n = 4) and control animals (n = 4) from our previous study.
RESULTS: As juveniles, the MIA offspring differed from control animals on several measures of social attention, particularly when viewing macaque faces depicting the fear grimace facial expression. Compared with control animals, MIA offspring had a longer latency before fixating on the eyes, had fewer fixations directed at the eyes, and spent less total time fixating on the eyes of the fear grimace images.
CONCLUSIONS: In the rhesus monkey model, exposure to MIA at the end of the first trimester results in abnormal gaze patterns to salient social information. The use of noninvasive eye tracking extends the findings from rodent MIA models to more human-like behaviors resembling those in both autism spectrum disorder and schizophrenia.
C1 [Machado, Christopher J.; Whitaker, Alexander M.; Bauman, Melissa D.] Univ Calif Davis, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
[Machado, Christopher J.; Whitaker, Alexander M.; Bauman, Melissa D.] Calif Natl Primate Res Ctr, Davis, CA USA.
[Smith, Stephen E. P.; Patterson, Paul H.] CALTECH, Div Biol, Pasadena, CA 91125 USA.
[Bauman, Melissa D.] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA.
RP Bauman, MD (reprint author), Univ Calif Davis, MIND Inst, 2825 50th St 1416, Sacramento, CA 95817 USA.
EM mdbauman@ucdavis.edu
FU Simons Foundation [SFARI 9900060]; Center for Neuroscience at the
University of California, Davis; California National Primate Research
Center [RR00169]
FX This work was supported by a grant from the Simons Foundation (SFARI
9900060 to PHP) and by a gift from Ted and Ginger Jenkins. Additional
support was provided by the Center for Neuroscience at the University of
California, Davis, and the base grant (RR00169) of the California
National Primate Research Center. SEPS is currently affiliated with
Department of Immunology, Mayo Clinic, Rochester, Minnesota.
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NR 104
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 823
EP 832
DI 10.1016/j.biopsych.2014.07.035
PG 10
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800009
PM 25442006
ER
PT J
AU McKeague, IW
Brown, AS
Bao, YY
Hinkka-Yli-Salomaki, S
Huttunen, J
Sourander, A
AF McKeague, Ian W.
Brown, Alan S.
Bao, Yuanyuan
Hinkka-Yli-Salomaki, Susanna
Huttunen, Jukka
Sourander, Andre
TI Autism with Intellectual Disability Related to Dynamics of Head
Circumference Growth during Early Infancy
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autism; Development; Epidemiology; Growth Velocity; Head Circumference;
Trajectories
ID EARLY BRAIN OVERGROWTH; AGE 2 YEARS; SPECTRUM DISORDER; 1ST YEAR;
ACCELERATED HEAD; BODY GROWTH; CHILDREN; LIFE; ENLARGEMENT; REGRESSION
AB BACKGROUND: It is not yet definitively known whether dynamic features of head circumference growth are associated with autism. To address this issue, we carried out a nested matched case-control study using data from national well baby clinics in Finland; autism cases were identified from the Finnish Hospital and Outpatient Discharge Registry.
METHODS: A nonparametric Bayesian method was used to construct growth velocity trajectories between birth and 2 years of age in autism cases and matched control subjects (n = 468 in main analyses, 1:1 matched control subjects). Estimates of odds ratios for autism risk in relation to the growth velocities were obtained using conditional logistic regression.
RESULTS: Growth velocity of head circumference at 3 months of age, adjusting for gestational age at birth and maternal age, is significantly associated with autism (p = .014); the finding was observed in subjects with comorbid intellectual disability (ID) (p = .025) but not in those without ID (p = .15). Height growth velocity among subjects with autism and without ID is significantly associated with autism at 6 months (p = .007), and weight growth velocity at 18 months without ID (p = .02) and 24 months without ID (p = .042) and with ID (p = .037).
CONCLUSIONS: Acceleration in head circumference growth is associated with autism with comorbid ID at 3 months but not subsequently. This association is unrelated to acceleration in height and weight, which are not strongly associated with autism until after 6 months.
C1 [McKeague, Ian W.] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA.
[Brown, Alan S.; Bao, Yuanyuan; Sourander, Andre] Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York State Psychiat Inst, New York, NY USA.
[Brown, Alan S.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
[Hinkka-Yli-Salomaki, Susanna; Huttunen, Jukka; Sourander, Andre] Univ Turku, Dept Child Psychiat, Fac Med, Turku 20014, Finland.
RP Sourander, A (reprint author), Univ Turku, Dept Child Psychiat, Fac Med, Turku 20014, Finland.
EM andsou@utu.fi
FU National Institutes of Health [R01GM095722-01]; National Institute of
Environmental Health Sciences Grant [1R01ES019004]; National Institute
of Mental Health [K02MH065422]
FX The work was supported by National Institutes of Health Grant
R01GM095722-01, National Institute of Environmental Health Sciences
Grant 1R01ES019004, and National Institute of Mental Health Grant
K02MH065422. The funding organizations had no role in design and conduct
of the study; collection, management, analysis, and interpretation of
the data; and preparation, review, or approval of the manuscript.
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NR 39
TC 0
Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2015
VL 77
IS 9
BP 833
EP 840
DI 10.1016/j.biopsych.2014.08.008
PG 8
WC Neurosciences; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA CE8LM
UT WOS:000352093800010
PM 25444163
ER
PT J
AU Bradford, EEF
Jentzsch, I
Gomez, JC
AF Bradford, Elisabeth E. F.
Jentzsch, Ines
Gomez, Juan-Carlos
TI From self to social cognition: Theory of Mind mechanisms and their
relation to Executive Functioning
SO COGNITION
LA English
DT Article
DE Theory of Mind; False belief; Belief attribution; Social cognition
ID INDIVIDUAL-DIFFERENCES; PERSPECTIVE-TAKING; INHIBITORY CONTROL;
ASPERGER-SYNDROME; FALSE BELIEF; DUAL-TASK; AUTISM; ADULTS; CHILDREN;
REPRESENTATION
AB 'Theory of Mind' refers to the ability to attribute mental states to oneself and other people (Premack 82 Woodruff, 1978). This study examined the extent to which 'Self' and 'Other' belief-attribution processes within the Theory of Mind (TOM) mechanism could be distinguished behaviourally, and whether these separable components differentially related to Executive Functioning (EF) abilities. A computerized false-belief task, utilizing a matched-design to allow direct comparison of self-oriented vs. other-oriented belief-attribution, was used to assess ToM, and a face-image Stroop task was employed to assess EF, within a population of typically-developed adults. Results revealed significantly longer reaction times when attributing beliefs to other people as opposed to recognizing and attributing beliefs to oneself. Intriguingly, results revealed that 'perspective-shift' requirements (i.e. changing from adoption of the 'self' perspective to the perspective of the 'other', or vice versa) across false-belief trials influenced reaction times. Reaction times were significantly longer when the perspective shift was from self-to-other than from other-to-self. It is suggested that the 'self' forms the stem of understanding the 'other', and is therefore processed regardless of ultimate task demands; in contrast, the 'other' perspective is only processed when explicitly required. We conclude that adopting another person's perspective, even when their belief state is matched to one's own, requires more cognitive effort than recalling and reflecting on self-oriented belief-states. (C) 2015 The Authors. Published by Elsevier B.V.
C1 [Bradford, Elisabeth E. F.; Jentzsch, Ines; Gomez, Juan-Carlos] Univ St Andrews, Sch Psychol & Neurosci, St Andrews KY16 9JP, Fife, Scotland.
RP Bradford, EEF (reprint author), Univ St Andrews, Sch Psychol & Neurosci, St Andrews KY16 9JP, Fife, Scotland.
EM eefb@st-andrews.ac.uk; ij7@st-andrews.ac.uk; jg5@st-andrews.ac.uk
RI Jentzsch, Ines/A-1586-2010
FU Economic and Social Research Council [ES/J500136/1]
FX This work was supported by the Economic and Social Research Council
[grant number ES/J500136/1] in the form of a three-year PhD studentship
awarded to Elisabeth Bradford.
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NR 63
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-0277
EI 1873-7838
J9 COGNITION
JI Cognition
PD MAY
PY 2015
VL 138
BP 21
EP 34
DI 10.1016/j.cognition.2015.02.001
PG 14
WC Psychology, Experimental
SC Psychology
GA CE9ON
UT WOS:000352173400003
PM 25704580
ER
PT J
AU Loepke, AW
Hansen, TG
AF Loepke, Andreas W.
Hansen, Tom G.
TI Is this your (paediatric patient's) brain on (anaesthetic) drugs? The
search for a potential neurological phenotype of anaesthesia-related
neurotoxicity in humans
SO EUROPEAN JOURNAL OF ANAESTHESIOLOGY
LA English
DT Editorial Material
ID AUTISM
C1 [Loepke, Andreas W.] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Anesthesiol, Div Pediat Cardiac Anesthesia,Coll Med, Cincinnati, OH USA.
[Hansen, Tom G.] Odense Univ Hosp, Dept Anesthesiol & Intens Care, DK-5000 Odense, Denmark.
[Hansen, Tom G.] Univ Southern Denmark, Inst Clin, Anesthesiol, Odense, Denmark.
RP Loepke, AW (reprint author), Cincinnati Childrens Hosp Med Ctr, Dept Anesthesiol, 3333 Burnet Ave, Cincinnati, OH 45229 USA.
EM pedsanesthesia@gmail.com
CR de Lima AD, 2004, EUR J NEUROSCI, V19, P2931, DOI 10.1111/j.1460-9568.2004.03403.x
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NR 11
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0265-0215
EI 1365-2346
J9 EUR J ANAESTH
JI Eur. J. Anaesth.
PD MAY
PY 2015
VL 32
IS 5
BP 298
EP 300
DI 10.1097/EJA.0000000000000148
PG 3
WC Anesthesiology
SC Anesthesiology
GA CF4AN
UT WOS:000352490800002
PM 25840346
ER
PT J
AU Bai, Z
Blackwell, AF
Coulouris, G
AF Bai, Zhen
Blackwell, Alan F.
Coulouris, George
TI Using Augmented Reality to Elicit Pretend Play for Children with Autism
SO IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
LA English
DT Article
DE Augmented Reality; pretend play; children; autism
ID SYMBOLIC PLAY; MIND
AB Children with autism spectrum condition (ASC) suffer from deficits or developmental delays in symbolic thinking. In particular, they are often found lacking in pretend play during early childhood. Researchers believe that they encounter difficulty in generating and maintaining mental representation of pretense coupled with the immediate reality. We have developed an interactive system that explores the potential of Augmented Reality (AR) technology to visually conceptualize the representation of pretense within an open-ended play environment. Results from an empirical study involving children with ASC aged 4 to 7 demonstrated a significant improvement of pretend play in terms of frequency, duration and relevance using the AR system in comparison to a non computer-assisted situation. We investigated individual differences, skill transfer, system usability and limitations of the proposed AR system. We discuss design guidelines for future AR systems for children with ASC and other pervasive developmental disorders.
C1 [Bai, Zhen] Univ Cambridge, Comp Lab, Graph & Interact Grp, Cambridge CB3 0FD, England.
[Blackwell, Alan F.] Univ Cambridge, Comp Lab, Interdisciplinary Design, Cambridge CB3 0FD, England.
[Coulouris, George] Univ Cambridge, Comp Lab, Cambridge CB3 0FD, England.
RP Bai, Z (reprint author), Univ Cambridge, Comp Lab, Graph & Interact Grp, Cambridge CB3 0FD, England.
EM zhen.bai@cl.cam.ac.uk; alan.blackwell@cl.cam.ac.uk;
george.coulouris@cl.cam.ac.uk
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
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NR 33
TC 0
Z9 0
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1077-2626
EI 1941-0506
J9 IEEE T VIS COMPUT GR
JI IEEE Trans. Vis. Comput. Graph.
PD MAY 1
PY 2015
VL 21
IS 5
BP 598
EP 610
DI 10.1109/TVCG.2014.2385092
PG 13
WC Computer Science, Software Engineering
SC Computer Science
GA CE9HJ
UT WOS:000352154500006
ER
PT J
AU Ference, J
Curtin, S
AF Ference, Jennifer
Curtin, Suzanne
TI The Ability to Map Differentially Stressed Labels to Objects Predicts
Language Development at 24 months in 12-month-olds at High Risk for
Autism
SO INFANCY
LA English
DT Article
ID ENGLISH-LEARNING INFANTS; SPECTRUM DISORDERS; WORD SEGMENTATION;
BIRTH-WEIGHT; PATTERN-DISCRIMINATION; SPEECH; CHILDREN; PERCEPTION;
PREFERENCES; 5-MONTH-OLDS
AB Sensitivity to language-specific stress patterns during infancy facilitates finding, mapping, and recognizing words, and early preferences for the predominate stress pattern of the infant's native language have been argued to facilitate language relevant outcomes (Ference & Curtin, 2013 Journal of Experimental Child Psychology, 116, 891; Weber etal., 2005 Cognitive Brain Research, 25, 180). We examined 12-month-old infant siblings of typically developing children (SIBS-TD) and infant siblings of children diagnosed with autism spectrum disorder (ASD; SIBS-A) on their ability to map differentially stressed labels to objects. We also examined whether success at this task relates to infants' vocabulary size at 12months, and more specifically to SIBS-A's vocabulary at both 12 and 24months. SIBS-TD successfully mapped the word-object pairings, which related to their vocabulary comprehension at 12months. In contrast, SIBS-A as a group did not map the word-object pairings, which was unrelated to vocabulary size at 12months. However, success on this task for SIBS-A predicted expressive language abilities at 24months using the Mullen Scales of Early Learning (MSEL; Mullen, 1995 Mullen Scales of Early Learning. Circle Pines, MN: American Guidance) and the MacArthur-Bates Communicative Development Inventory (MB-CDI; Fenson etal., 1993 MacArthur Communicative Development Inventory: Users Guide and Technical Manual. San Diego, CA: Singular Publishing Company). Our study is the first to demonstrate that 12-month-old SIBS-A who succeed at word mapping using lexical stress are more likely to have stronger expressive language abilities at 24months.
C1 [Ference, Jennifer; Curtin, Suzanne] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
RP Curtin, S (reprint author), Univ Calgary, Dept Psychol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM scurtin@ucalgary.ca
FU Alberta Centre for Child, Family, and Community Research (ACCFCR)
FX This research was supported by funding from an Alberta Centre for Child,
Family, and Community Research (ACCFCR) research grant awarded to
Suzanne Curtin. We thank the parents and infants who participated as
well as Jennifer Campbell, Danielle Droucker, and Melanie Khu for their
assistance with this research.
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NR 49
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1525-0008
EI 1532-7078
J9 INFANCY
JI Infancy
PD MAY-JUN
PY 2015
VL 20
IS 3
BP 242
EP 262
DI 10.1111/infa.12074
PG 21
WC Psychology, Developmental
SC Psychology
GA CF4BE
UT WOS:000352492600002
ER
PT J
AU Aydin, S
Arica, N
Ergul, E
Tan, O
AF Aydin, Serap
Arica, Nafiz
Ergul, Emrah
Tan, Oguz
TI Classification of Obsessive Compulsive Disorder by EEG Complexity and
Hemispheric Dependency Measurements
SO INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
LA English
DT Article
DE Approximate entropy; sample entropy; permutation entropy; mutual
information; SVM
ID FUZZY SYNCHRONIZATION LIKELIHOOD; ALZHEIMERS-DISEASE PATIENTS; MUTUAL
INFORMATION ANALYSIS; NEURAL NETWORK METHODOLOGY; WAVELET-CHAOS
METHODOLOGY; AUTISM SPECTRUM DISORDER; APPROXIMATE ENTROPY; SAMPLE
ENTROPY; PERMUTATION ENTROPY; BACKGROUND ACTIVITY
AB In the present study, both single channel electroencephalography(EEG)complexity and two channel interhemispheric dependency measurements have newly been examined for classification of patients with obsessive-compulsive disorder (OCD) and controls by using support vector machine classifiers. Three embedding entropy measurements (approximate entropy, sample entropy, permutation entropy (PermEn)) are used to estimate single channel EEG complexity for 19-channel eyes closed cortical measurements. Mean coherence and mutual information are examined to measure the level of interhemispheric dependency in frequency and statistical domain, respectively for eight distinct electrode pairs placed on the scalp with respect to the international 10-20 electrode placement system. All methods are applied to short EEG segments of 2 s. The classification performance is measured 20 times with different 2-fold cross-validation data for both single channel complexity features (19 features) and interhemispheric dependency features (eight features). The highest classification accuracy of 85 +/- 5.2% is provided by PermEn at prefrontal regions of the brain. Even if the classification success do not provided by other methods as high as PermEn, the clear differences between patients and controls at prefrontal regions can also be obtained by using other methods except coherence. In conclusion, OCD, defined as illness of orbitofronto-striatal structures [Beucke et al., JAMA Psychiatry 70 (2013) 619-629; Cavedini et al., Psychiatry Res. 78 (1998) 21-28; Menzies et al., Neurosci. Biobehav. Rev. 32(3) (2008) 525-549], is caused by functional abnormalities in the pre-frontal regions. Particularly, patients are characterized by lower EEG complexity at both pre-frontal regions and right fronto-temporal locations. Our results are compatible with imaging studies that define OCD as a sub group of anxiety disorders exhibited a decreased complexity (such as anorexia nervosa [Toth et al., Int. J. Psychophysiol. 51(3) (2004) 253-260] and panic disorder [Bob et al., Physiol. Res. 55 (2006) S113-S119]).
C1 [Aydin, Serap] Bahcesehir Univ, Dept Biomed Engn, TR-34353 Istanbul, Turkey.
[Arica, Nafiz] Bahcesehir Univ, Software Engn Dept, TR-34353 Istanbul, Turkey.
[Ergul, Emrah] Kocaeli Univ, Elect & Commun Engn Dept, Kocaeli, Turkey.
[Tan, Oguz] Uskudar Univ, Neuropsychiat Hlth Practice & Res Ctr, Istanbul, Turkey.
RP Aydin, S (reprint author), Bahcesehir Univ, Dept Biomed Engn, TR-34353 Istanbul, Turkey.
EM drserapaydin@hotmail.com; nafiz.arica@eng.bahcesehir.edu.tr;
106103002@kocaeli.edu.tr; oguz.tan@uskudar.edu.tr
RI ahmed, Jamila/E-8653-2015
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NR 91
TC 0
Z9 0
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0129-0657
EI 1793-6462
J9 INT J NEURAL SYST
JI Int. J. Neural Syst.
PD MAY
PY 2015
VL 25
IS 3
AR 1550010
DI 10.1142/S0129065715500100
PG 16
WC Computer Science, Artificial Intelligence
SC Computer Science
GA CF6AZ
UT WOS:000352640100005
PM 25804351
ER
PT J
AU Zhou, ZB
Yang, XY
Yuan, BL
Niu, LJ
Zhou, X
Huang, WQ
Feng, X
Zhou, LH
AF Zhou, Zhi-Bin
Yang, Xiao-Yu
Yuan, Bao-Long
Niu, Li-Jun
Zhou, Xue
Huang, Wen-Qi
Feng, Xia
Zhou, Li-Hua
TI Sevoflurane-Induced Down-regulation of Hippocampal Oxytocin and Arginine
Vasopressin Impairs Juvenile Social Behavioral Abilities
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Sevoflurane; Oxytocin; Arginine vasopressin; Hippocampus; Social
behavior
ID AUTISM SPECTRUM DISORDERS; NEUROENDOCRINE BASIS; EARLY EXPOSURE;
RECOGNITION; RATS; ANESTHESIA; MICE; EPIGENETICS; AMYGDALA; HUMANS
AB Cumulative evidence indicates that early childhood anesthesia can alter a child's future behavioral performance. Animal researchers have found that sevoflurane, the most commonly used anesthetic for children, can produce damage in the neonatal brains of rodents. To further investigate this phenomenon, we focused on the influence of sevoflurane anesthesia on the development of juvenile social behavioral abilities and the pro-social proteins oxytocin (OT) and arginine vasopressin (AVP) in the neonatal hippocampus. A single 6-h sevoflurane exposure for postnatal day 5 mice resulted in decreased OT and AVP messenger RNA (mRNA) and protein levels in the hippocampus. OT and AVP proteins became sparsely distributed in the dorsal hippocampus after the exposure to sevoflurane. Compared with the air-treated group, mice in the sevoflurane-treated group showed signs of impairment in social recognition memory formation and social discrimination ability. Sevoflurane anesthesia reduces OT and AVP activities in the neonatal hippocampus and impairs social recognition memory formation and social discrimination ability in juvenile mice.
C1 [Zhou, Zhi-Bin; Yang, Xiao-Yu; Yuan, Bao-Long; Niu, Li-Jun; Zhou, Xue; Huang, Wen-Qi; Feng, Xia] Sun Yat Sen Univ, Dept Anesthesiol, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China.
[Zhou, Li-Hua] Sun Yat Sen Univ, Zhong Shan Med Coll, Dept Anat, Guangzhou 510275, Guangdong, Peoples R China.
RP Feng, X (reprint author), Sun Yat Sen Univ, Dept Anesthesiol, Affiliated Hosp 1, 58 Zhongshan 2nd Rd, Guangzhou 510275, Guangdong, Peoples R China.
EM zhouzhibin1986@aliyun.com; wooyoung@163.com; yuanbl6523@163.com;
183513575@qq.com; 550145912@qq.com; huangwenqisysu@163.com;
fengxia@mail.sysu.edu.cn; zhoulih@mail.sysu.edu.cn
RI ahmed, Jamila/E-8653-2015
FU Guangdong Science and Technology Planning Project [2011B050400024];
Guangzhou International Science and Technology Cooperation Project
[2012J5100019]
FX This work was supported by Funding from Guangdong Science and Technology
Planning Project (No. 2011B050400024) and Guangzhou International
Science and Technology Cooperation Project (No. 2012J5100019). The
sources of funding had no role in the design and conduct of this project
or in the preparation of the manuscript.
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NR 39
TC 0
Z9 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD MAY
PY 2015
VL 56
IS 1
BP 70
EP 77
DI 10.1007/s12031-014-0468-3
PG 8
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA CF0VW
UT WOS:000352263400008
PM 25417719
ER
PT J
AU Shen, C
Huo, LR
Zhao, XL
Wang, PR
Zhong, N
AF Shen, Chen
Huo, Li-rong
Zhao, Xin-liang
Wang, Pei-rong
Zhong, Nanbert
TI Novel Interactive Partners of Neuroligin 3: New Aspects for Pathogenesis
of Autism
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE NLGN3; Yeast two-hybrid; Co-immunoprecipitation; Protein-protein
interaction; Co-localization; Cytosolic calcium
ID SPECTRUM DISORDERS; ENDOPLASMIC-RETICULUM; SYNAPTIC PATHOPHYSIOLOGY;
FILAMIN-A; PROTEIN; MUTATIONS; MOUSE; VITAMIN-D-3; HIPPOCAMPAL; RECEPTOR
AB Autism is a neurodevelopmental disorder with a strong genetic predisposition. Neurolign 3 (NLGN3) as a postsynaptic transmembrane protein, functions in both neuron synaptogenesis and glia-neuron communications. Previously, a gain of function mutation (R451C) in NLGN3 was identified in autistic patients, which illustrates the involvement of NLGN3 in autism pathogenesis. As proper synaptic targeting and functioning are controlled by intracellular protein interactions, in the current study, we tried to discover the intracellular regulation network in which NLGN3 might be involved by a yeast two-hybrid-based interactor identification. Fifty-one protein candidate partners were identified after screening a human fetal complementary DNA (cDNA) library with an intracellular fragment of NLGN3. The interactions of NLGN3 with a subset of candidates, including EEF1A1, FLNA, ITPRIP, CYP11A1, MT-CO2, GPR175, ACOT2, and QPRT, were further validated in human neuroblastoma cells or brain tissues. Furthermore, our study suggested that NLGN3 was functioning in cytosolic calcium balance and participating in calcium-regulated cellular processes. Our findings of novel NLGN3 binding partners provide evidences of involvement of NLGN3 in multiple biological pathways, especially calcium regulating and mitochondrial function, thus suggesting further significance. This new data not only leads to a better understanding of the physiological functions of NLGN3, but also provide new aspects for pathogenesis of autism.
C1 [Shen, Chen; Huo, Li-rong; Zhao, Xin-liang; Wang, Pei-rong; Zhong, Nanbert] Peking Univ, Ctr Med Genet, Beijing 100191, Peoples R China.
[Shen, Chen] Capital Med Univ, Beijing Pediat Res Inst, Minist Educ, Key Lab Major Dis Children,State Key Discipline P, Beijing 100045, Peoples R China.
[Shen, Chen] Capital Med Univ, Beijing Childrens Hosp, Beijing 100045, Peoples R China.
[Huo, Li-rong] Capital Med Univ, Fu Xing Hosp, Dept Neurol, Beijing 100038, Peoples R China.
[Zhong, Nanbert] New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA.
RP Zhong, N (reprint author), New York State Inst Basic Res Dev Disabil, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA.
EM nanbert.zhong@opwdd.ny.gov
RI ahmed, Jamila/E-8653-2015
FU "973" project of the Chinese Ministry of Sciences and technology
[2012CB517905]; National Nature Science Foundation [30671157, 81301403];
Shanghai Municipal Department of Science and Technology [2009JC1412600];
New York State Office of Mental Retardation and Developmental
Disabilities (NYS OMRDD)
FX This work was supported in part by the "973" project (2012CB517905) of
the Chinese Ministry of Sciences and technology, National Nature Science
Foundation (30671157, 81301403), the Shanghai Municipal Department of
Science and Technology (2009JC1412600), and the New York State Office of
Mental Retardation and Developmental Disabilities (NYS OMRDD).
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NR 53
TC 0
Z9 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD MAY
PY 2015
VL 56
IS 1
BP 89
EP 101
DI 10.1007/s12031-014-0470-9
PG 13
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA CF0VW
UT WOS:000352263400010
PM 25464930
ER
PT J
AU Barger, N
Sheley, MF
Schumann, CM
AF Barger, Nicole
Sheley, Matthew F.
Schumann, Cynthia M.
TI Stereological Study of Pyramidal Neurons in the Human Superior Temporal
Gyrus From Childhood to Adulthood
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE temporal lobe; development; cerebral cortex; nucleator; fractionators;
pyramidal neuron
ID HUMAN CEREBRAL-CORTEX; HUMAN PREFRONTAL CORTEX; HUMAN BRAIN;
AUDITORY-CORTEX; AEROBIC GLYCOLYSIS; SOCIAL-PERCEPTION; FUSIFORM GYRUS;
TOTAL NUMBER; AUTISM; SULCUS
AB The association cortex of the superior temporal gyrus (STG) is implicated in complex social and linguistic functions. Thus, reliable methods for quantifying cellular variation in this region could greatly benefit researchers interested in addressing the cellular correlates of typical and atypical function associated with these critical cognitive abilities. To facilitate this task, we first present a general set of cytoarchitectonic criteria targeted specifically toward stereological analyses of thick, Nissl-stained sections for the homotypical cortex of the STG, referred to here as BA22/TA. Second, we use the optical fractionator to estimate pyramidal neuron number and the nucleator for pyramidal somal and nuclear volume. We also investigated the influence of age and sex on these parameters, as well as set a typically developing baseline for future comparisons. In 11 typically developing cases aged 4-48 years, the most distinguishing features of BA22/TA were the presence of distinct granular layers, a prominent, jagged layer IIIc, and a distinctly staining VIa. The average number of neurons was 91 +/- 15 million, the volume of pyramidal soma 1,512 mu m(3), and the nuclear volume 348 mu m(3). We found no correlation with age and neuron number. In contrast, pyramidal somal and nuclear volume were both negatively correlated and linearly associated with age in regression analyses. We found no significant sex differences. Overall, the data support the idea that postnatal neuron numbers are relatively stable through development but also suggest that neuronal volume may be subject to important developmental variation. Both measures are critical variables in the study of developmental neuropathology. (C) 2015 Wiley Periodicals, Inc.
C1 [Barger, Nicole; Schumann, Cynthia M.] Univ Calif Davis, Dept Psychiat & Behav Sci, MIND Inst, Sacramento, CA 95817 USA.
[Sheley, Matthew F.] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA.
RP Barger, N (reprint author), Univ Calif Davis, Dept Psychiat & Behav Sci, MIND Inst, 2805 50th St, Sacramento, CA 95817 USA.
EM nbarger@ucdavis.edu
FU National Institutes of Health [T32 MH073124, R01 MH 097236]; University
of California Davis MIND Institute
FX Grant sponsor: National Institutes of Health; Grant numbers: T32
MH073124 (to N.B.) and R01 MH 097236(to M.F.S. and C.M.S.); Grant
sponsor: University of California Davis MIND Institute(to M.F.S. and
C.M.S.).
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NR 77
TC 0
Z9 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9967
EI 1096-9861
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD MAY 1
PY 2015
VL 523
IS 7
BP 1054
EP 1072
DI 10.1002/cne.23707
PG 19
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA CE9CQ
UT WOS:000352141600003
PM 25556320
ER
PT J
AU Severance, EG
Prandovszky, E
Castiglione, J
Yolken, RH
AF Severance, Emily G.
Prandovszky, Emese
Castiglione, James
Yolken, Robert H.
TI Gastroenterology Issues in Schizophrenia: Why the Gut Matters
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Microbiome; Autoimmunity; Blood-brain barrier; Gluten; Autism; Synapses
ID CENTRAL-NERVOUS-SYSTEM; REGULATORY T-CELLS; BARRIER FUNCTION;
IMMUNE-RESPONSE; CELIAC-DISEASE; FREE DIET; GASTROINTESTINAL
INFLAMMATION; RELAPSED SCHIZOPHRENICS; INTESTINAL MICROBIOTA; HOSPITAL
ADMISSIONS
AB Genetic and environmental studies implicate immune pathologies in schizophrenia. The body's largest immune organ is the gastrointestinal (GI) tract. Historical associations of GI conditions with mental illnesses predate the introduction of antipsychotics. Cuirent studies of antipsychotic-naive patients support that gut dysfunction may be inherent to the schizophrenia disease process. Risk factors for schizophrenia (inflammation, food intolerances, Toxoplasma gondii exposure, cellular barrier defects) are part of biological pathways that intersect those operant in the gut. Central to GI function is a homeostatic microbial community, and early reports show that it is disrupted in schizophrenia. Bioactive and toxic products derived from digestion and microbial dysbiosis activate adaptive and innate immunity. Complement Clq, a brain-active systemic immune component, interacts with gut-related schizophrenia risk factors in clinical and experimental animal models. With accumulating evidence supporting newly discovered gut brain physiological pathways, treatments to ameliorate brain symptoms of schizophrenia should be supplemented with therapies to correct GI dysfunction.
C1 [Severance, Emily G.; Prandovszky, Emese; Yolken, Robert H.] Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA.
[Castiglione, James] CUNY Brooklyn Coll, Brooklyn, NY 11210 USA.
RP Severance, EG (reprint author), Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, 600 N Wolfe St,Blalock 1105, Baltimore, MD 21287 USA.
EM eseverance@jhmi.edu; eodonne3@jhmi.edu; jcast1@optonline.net;
rhyolken@gmail.com
FU NIMH P50 Silvio O. Conte Center at Johns Hopkins [MH-94268]; Stanley
Medical Research Institute; Brain & Behavior Research Foundation
(NARSAD)
FX Emily G. Severance reports that this work was supported by a NIMH P50
Silvio O. Conte Center at Johns Hopkins (grant no. MH-94268) and by the
Stanley Medical Research Institute. Dr. Severance also has received a
grant from the Brain & Behavior Research Foundation (NARSAD) and has
received support for travel to meetings from the Stanley Medical
Research Institute.Emese Prandovszky has received a grant and support
for travel to meetings from the Stanley Medical Research Institute.
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NR 125
TC 0
Z9 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD MAY
PY 2015
VL 17
IS 5
DI 10.1007/s11920-015-0574-0
PG 10
WC Psychiatry
SC Psychiatry
GA CD9TO
UT WOS:000351441500001
ER
PT J
AU Roffeei, SHM
Abdullah, N
BasarDepartment, SKR
AF Roffeei, Siti Hajar Mohd
Abdullah, Noorhidawati
BasarDepartment, Siti Khairatul Razifah
TI Seeking social support on Facebook for children with Autism Spectrum
Disorders (ASDs)
SO INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
LA English
DT Article
DE Social support; Support group; Facebook; Autism; ASD
ID ONLINE SUPPORT; COMMUNICATION; SATISFACTION; HEALTH
AB Purpose: This study examined the types of social support messages exchanged between parents and/or caregivers of children with Autism Spectrum Disorders (ASDs) who communicate via Facebook (FB); it studies two autism support groups: Autism Malaysia (AM) and Autism Children Club (ACA).
Method: A total of 3637 messages including both postings (381) and comments (3256) were gathered from August to November 2013. The study employed a deductive content-analysis approach. The qualitative data were analyzed for social support themes adapted from the Social Support Behavior Code (SSBC). Before collecting the data, email was sent to the FB groups' moderators to gain formal consent from the members.
Result: The finding indicated that the highest percentage of messages offered dealt with Informational support (30.7%) followed by Emotional support (27.8%). Network and Esteem support messages were responsible for 20.97% and 20.2%, respectively. Tangible Assistance was the least frequent category (0.4%). A majority of these messages discussed and addressed challenges and difficulties associated with caring and raising ASD children, as well as issues such as children's social lives and self-care routines.
Conclusion: Understandings of how FB is used to seek social support could impact supporting and maintaining effective communication among parents and/or caregivers of children with ASDs. This information could also improve approaches used by health professionals in developing, improving and evaluating social support systems for parents/caregivers. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Roffeei, Siti Hajar Mohd; Abdullah, Noorhidawati; BasarDepartment, Siti Khairatul Razifah] Univ Malaya, Fac Comp Sci & Informat Technol, Dept Lib & Informat Sci, Kuala Lumpur 50603, Malaysia.
RP Abdullah, N (reprint author), Univ Malaya, Fac Comp Sci & Informat Technol, Dept Lib & Informat Sci, Kuala Lumpur 50603, Malaysia.
EM hajaroff@gmail.com; noorhidawati@um.edu.my; razifabasar@yahoo.com
FU University of Malaya High Impact Research Grant
[UM.C/625/1/HIR/MOHE/FCSIT/16/H-22001-00-B00016]
FX This research was partially funded by the University of Malaya High
Impact Research Grant (No:
UM.C/625/1/HIR/MOHE/FCSIT/16/H-22001-00-B00016).
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NR 23
TC 0
Z9 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 1386-5056
EI 1872-8243
J9 INT J MED INFORM
JI Int. J. Med. Inform.
PD MAY
PY 2015
VL 84
IS 5
BP 375
EP 385
DI 10.1016/j.ijmedinf.2015.01.015
PG 11
WC Computer Science, Information Systems; Health Care Sciences & Services;
Medical Informatics
SC Computer Science; Health Care Sciences & Services; Medical Informatics
GA CD3HH
UT WOS:000350968500010
ER
PT J
AU Isogai, T
van der Kammen, R
Innocenti, M
AF Isogai, Tadamoto
van der Kammen, Rob
Innocenti, Metello
TI SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton
SO SCIENTIFIC REPORTS
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; BETA-ACTIN LOCUS; MICROTUBULE DYNAMICS;
GOLGI-COMPLEX; MEDIATED DEGRADATION; ADHESION MATURATION; NEURONAL
MIGRATION; DRIVES INVASION; CANCER-CELLS; IN-VIVO
AB Formin proteins are key regulators of the cytoskeleton involved in developmental and homeostatic programs, and human disease. For these reasons, small molecules interfering with Formins' activity have gained increasing attention. Among them, small molecule inhibitor of Formin Homology 2 domains (SMIFH2) is often used as a pharmacological Formin blocker. Although SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton, its cellular mechanism of action and target specificity remain unclear.
Here we show that SMIFH2 induces remodelling of actin filaments, microtubules and the Golgi complex as a result of its effects on Formins and p53.
We found that SMIFH2 triggers alternated depolymerization-repolymerization cycles of actin and tubulin, increases cell migration, causes scattering of the Golgi complex, and also cytotoxicity at high dose. Moreover, SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton.
As the action of SMIFH2 may go beyond Formin inhibition, only short-term and low-dose SMIFH2 treatments minimize confounding effects induced by loss of p53 and cytotoxicity.
C1 [Isogai, Tadamoto; van der Kammen, Rob; Innocenti, Metello] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands.
RP Innocenti, M (reprint author), Netherlands Canc Inst, Div Mol Genet, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
EM m.innocenti@nki.nl
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NR 82
TC 0
Z9 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 30
PY 2015
VL 5
AR 9802
DI 10.1038/srep09802
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CH3AL
UT WOS:000353897800001
PM 25925024
ER
PT J
AU Herrmann, MJ
Bogon, J
Quester, S
Cordes, A
Stenneken, P
Reif, A
Ehlis, AC
AF Herrmann, M. J.
Bogon, J.
Quester, S.
Cordes, A.
Stenneken, P.
Reif, A.
Ehlis, A. -C.
TI SEROTONIN TRANSPORTER POLYMORPHISM MODULATES NEURAL CORRELATES OF
REAL-LIFE JOINT ACTION. AN INVESTIGATION WITH FUNCTIONAL NEAR-INFRARED
SPECTROSCOPY (FNIRS)
SO NEUROSCIENCE
LA English
DT Article
DE NIRS; joint-action; 5-HTTLPR
ID BRAIN ACTIVATION; TASK; NIRS; MECHANISMS; EXPRESSION; ATTENTION;
VERSION; SYSTEM; AUTISM; CORTEX
AB A functional polymorphism (5-HTTLPR) within the serotonin transporter gene (SERT) has been associated with personality dimensions such as neuroticism, with emotional reactivity to negative events, and with an increased risk of affective disorders. More specifically, the short (S) allele of 5-HTTLPR has been linked to increased amygdala activity and has been identified as a risk allele for depressive disorders. Recently, Homberg and Lesch (2011) urged for a conceptual change in the current deficit-oriented connotation of the 5-HTTLPR S-allele and argued that the S-allele could be considered adaptive in certain contexts. They postulated that S-allele carriers show hypervigilant behavior in social situations and should thus show increased social conformity. Therefore, we tested whether 5-HTTLPR modulates the neural correlates of real-life social joint action through functional near-infrared spectroscopy (fNIRS). Thirty participants, homozygote for 5-HTTLPR, were measured and analyzed while they were involved in a previously published joint-action paradigm, which reliably leads to an activation of the left parietal cortex. We found that homozygote S-allele carriers showed increased inferior parietal lobe activation, compared to the LL-allele carriers for the contrast "joint action greater solo action". Therefore, our results provide evidence for beneficial effects of the S-allele on the neural correlates of social interactions. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Herrmann, M. J.; Cordes, A.; Reif, A.] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, D-97080 Wurzburg, Germany.
[Bogon, J.] Univ Regensburg, Dept Psychol, D-93053 Regensburg, Germany.
[Quester, S.] Humboldt Univ, Berlin Sch Mind & Brain, D-10099 Berlin, Germany.
[Stenneken, P.] Univ Cologne, Dept Rehabil & Special Educ, D-50931 Cologne, Germany.
[Reif, A.] Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany.
[Ehlis, A. -C.] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany.
RP Herrmann, MJ (reprint author), Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Fuchsleinstr 15, D-97080 Wurzburg, Germany.
EM Herrmann_M@klinik.uni-wuerzburg.de
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NR 33
TC 0
Z9 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD APR 30
PY 2015
VL 292
BP 129
EP 136
DI 10.1016/j.neuroscience.2015.02.030
PG 8
WC Neurosciences
SC Neurosciences & Neurology
GA CE2RT
UT WOS:000351664700012
PM 25711941
ER
PT J
AU Braun, KVN
Christensen, D
Doernberg, N
Schieve, L
Rice, C
Wiggins, L
Schendel, D
Yeargin-Allsopp, M
AF Braun, Kim Van Naarden
Christensen, Deborah
Doernberg, Nancy
Schieve, Laura
Rice, Catherine
Wiggins, Lisa
Schendel, Diana
Yeargin-Allsopp, Marshalyn
TI Trends in the Prevalence of Autism Spectrum Disorder, Cerebral Palsy,
Hearing Loss, Intellectual Disability, and Vision Impairment,
Metropolitan Atlanta, 1991-2010
SO PLOS ONE
LA English
DT Article
ID DEVELOPMENTAL-DISABILITIES; CHILDREN; SURVEILLANCE; INFANTS
AB This study examined the prevalence and characteristics of autism spectrum disorder (ASD), cerebral palsy (CP), hearing loss (HL), intellectual disability (ID), and vision impairment (VI) over a 15-20 year time period, with specific focus on concurrent changes in ASD and ID prevalence. We used data from a population-based developmental disabilities surveillance program for 8-year-olds in metropolitan Atlanta. From 1991-2010, prevalence estimates of ID and HL were stable with slight increases in VI prevalence. CP prevalence was constant from 1993-2010. The average annual increase in ASD prevalence was 9.3% per year from 1996-2010, with a 269% increase from 4.2 per 1,000 in 1996 to 15.5 per 1,000 in 2010. From 2000-2010, the prevalence of ID without ASD was stable; during the same time, the prevalence of ASD with and without co-occurring ID increased by an average of 6.6% and 9.6% per year, respectively. ASD prevalence increases were found among both males and females, and among nearly all racial/ethnic subgroups and levels of intellectual ability. Average annual prevalence estimates from 1991-2010 underscore the significant community resources needed to provide early intervention and ongoing supports for children with ID (13.0 per 1,000), CP, (3.5 per 1,000), HL (1.4 per 1,000) and VI (1.3 in 1,000), with a growing urgency for children with ASD.
C1 [Braun, Kim Van Naarden; Christensen, Deborah; Doernberg, Nancy; Schieve, Laura; Rice, Catherine; Wiggins, Lisa; Schendel, Diana; Yeargin-Allsopp, Marshalyn] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Dev Disabil Branch, Atlanta, GA 30333 USA.
RP Braun, KVN (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Dev Disabil Branch, Atlanta, GA 30333 USA.
EM kbn5@cdc.gov
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NR 43
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 29
PY 2015
VL 10
IS 4
AR e0124120
DI 10.1371/journal.pone.0124120
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CH0LO
UT WOS:000353711600071
ER
PT J
AU Brandao, JA
Romcy-Pereira, RN
AF Brandao, Juliana A.
Romcy-Pereira, Rodrigo N.
TI Interplay of environmental signals and progenitor diversity on fate
specification of cortical GABAergic neurons
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Review
DE interneuron; cortical development; non-autonomous specification;
inhibitory circuit; cell identity
ID CAUDAL GANGLIONIC EMINENCE; EMBRYONIC PREOPTIC AREA; RAT FRONTAL-CORTEX;
CEREBRAL-CORTEX; INTERNEURON DEVELOPMENT; SONIC HEDGEHOG; CELL FATE;
NEURODEVELOPMENTAL DISORDERS; TELENCEPHALIC PROGENITORS; IMMUNOREACTIVE
NEURONS
AB Cortical GABAergic interneurons constitute an extremely diverse population of cells organized in a well-defined topology of precisely interconnected cells. They play a crucial role regulating inhibitory-excitatory balance in brain circuits, gating sensory perception, and regulating spike timing to brain oscillations during distinct behaviors. Dysfunctions in the establishment of proper inhibitory circuits have been associated to several brain disorders such as autism, epilepsy, and schizophrenia. In the rodent adult cortex, inhibitory neurons are generated during the second gestational week from distinct progenitor lineages located in restricted domains of the ventral telencephalon. However, only recently, studies have revealed some of the mechanisms generating the heterogeneity of neuronal subtypes and their modes of integration in brain networks. Here we will discuss some the events involved in the production of cortical GABAergic neuron diversity with focus on the interaction between intrinsically driven genetic programs and environmental signals during development.
C1 [Brandao, Juliana A.; Romcy-Pereira, Rodrigo N.] Univ Fed Rio Grande do Norte, Inst Brain, BR-59056450 Natal, RN, Brazil.
RP Romcy-Pereira, RN (reprint author), Univ Fed Rio Grande do Norte, Inst Brain, Ave Nascimento Castro 2155, BR-59056450 Natal, RN, Brazil.
EM mrpereira@neuro.ufrn.br
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NR 102
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD APR 28
PY 2015
VL 9
AR 149
DI 10.3389/fncel.2015.00149
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA CI5LS
UT WOS:000354798400001
PM 25972784
ER
PT J
AU Levin, IP
Gaeth, GJ
Foley-Nicpon, M
Yegorova, V
Cederberg, C
Yan, HY
AF Levin, Irwin P.
Gaeth, Gary J.
Foley-Nicpon, Megan
Yegorova, Vitaliya
Cederberg, Charles
Yan, Haoyang
TI Extending decision making competence to special populations: a pilot
study of persons on the autism spectrum
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE decision making; persons on the autism spectrum; risk taking; perception
of social norms; framing effects
ID HIGH-FUNCTIONING AUTISM; INDIVIDUAL-DIFFERENCES; YOUNG-ADULTS;
ASPERGERS-DISORDER; EMPATHY QUOTIENT; MIND; EMPLOYMENT; CHILDREN;
DEFICITS; DIFFICULTIES
AB The area of decision making has much to offer in our effort to understand special populations. This pilot study is an example of just such a project, where we illustrate how traditional decision making tools and tasks can be used to uncover strengths and weaknesses within a growing population of young adults with autism. In this pilot project we extended accounts of autistic behavior such as those derived from "theory of mind" to predict key components of decision making in high-functioning young adults on the autism spectrum. A battery of tests was administered to 15 high-functioning college students with autism spectrum disorder (ASD), focusing on decision making competence (DMC) and other aspects of decision making related to known deficits associated with autism. Data from this group were compared to data from unselected college students receiving the same measures. First, as a test of a key social deficit associated with autism, the target group scored much lower on the Empathy Quotient scale. Traditional elements of decision making competency such as Numeracy and application of decision rules were comparable across groups. However, there were differences in thinking style, with the ASD group showing lesser ability and engagement in intuitive thinking, and they showed lower levels of risk taking. For comparisons within the ASD group, autobiographical reports concerning individual lifestyles and outcomes were used to derive a scale of Social Functioning. The lowest scoring individuals showed the lowest levels of intuitive thinking, the lowest perceived levels of others' endorsement of socially undesirable behaviors, and the lowest ability to discriminate between "good" and "bad" risks. Results are discussed in terms of interventions that might aid high-functioning young adults with ASD in their everyday decision making.
C1 [Levin, Irwin P.] Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA.
[Gaeth, Gary J.] Univ Iowa, Dept Mkt, Iowa City, IA 52242 USA.
[Foley-Nicpon, Megan; Cederberg, Charles] Univ Iowa, Dept Psychol & Quantitat Fdn, Iowa City, IA 52242 USA.
[Yegorova, Vitaliya] Univ Iowa, Dept Social Work, Iowa City, IA 52242 USA.
[Yan, Haoyang] Univ Michigan, Dept Psychol, Ann Arbor, MI USA.
RP Levin, IP (reprint author), Univ Iowa, Dept Psychol, Seashore Hall,Iowa Ave,Gilbert St, Iowa City, IA 52242 USA.
EM irwin-levin@uiowa.edu
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NR 67
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD APR 28
PY 2015
VL 6
AR 539
DI 10.3389/fpsyg.2015.00539
PG 10
WC Psychology, Multidisciplinary
SC Psychology
GA CI1XP
UT WOS:000354538700002
PM 25972831
ER
PT J
AU Lundstrom, S
Reichenberg, A
Anckarsater, H
Lichtenstein, P
Gillberg, C
AF Lundstrom, Sebastian
Reichenberg, Abraham
Anckarsater, Henrik
Lichtenstein, Paul
Gillberg, Christopher
TI Autism phenotype versus registered diagnosis in Swedish children:
prevalence trends over 10 years in general population samples
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; AFFECTED SIBLING PAIRS; COMORBIDITIES
A-TAC; SPECTRUM DISORDERS; TELEPHONE INTERVIEW; PRESCHOOL-CHILDREN;
CHILDHOOD AUTISM; EPIDEMIOLOGY; RISK; SUBSTITUTION
AB OBJECTIVE To compare the annual prevalence of the autism symptom phenotype and of registered diagnoses for autism spectrum disorder during a 10 year period in children.
DESIGN Population based study.
SETTING Child and Adolescent Twin Study and national patient register, Sweden.
PARTICIPANTS 19 993 twins (190 with autism spectrum disorder) and all children (n=1 078 975; 4620 with autism spectrum disorder) born in Sweden over a 10 year period from 1993 to 2002.
MAIN OUTCOME MEASURES Annual prevalence of the autism symptom phenotype (that is, symptoms on which the diagnostic criteria are based) assessed by a validated parental telephone interview (the Autism-Tics, ADHD and other Comorbidities inventory), and annual prevalence of reported diagnoses of autism spectrum disorder in the national patient register.
RESULTS The annual prevalence of the autism symptom phenotype was stable during the 10 year period (P=0.87 for linear time trend). In contrast, there was a monotonic significant increase in prevalence of registered diagnoses of autism spectrum disorder in the national patient register (P<0.001 for linear trend).
CONCLUSIONS The prevalence of the autism symptom phenotype has remained stable in children in Sweden while the official prevalence for registered, clinically diagnosed, autism spectrum disorder has increased substantially. This suggests that administrative changes, affecting the registered prevalence, rather than secular factors affecting the pathogenesis, are important for the increase in reported prevalence of autism spectrum disorder.
C1 [Lundstrom, Sebastian; Gillberg, Christopher] Univ Gothenburg, Gillberg Neuropsychiat Ctr, S-41119 Gothenburg, Sweden.
[Lundstrom, Sebastian; Anckarsater, Henrik] Univ Gothenburg, Ctr Eth Law & Mental Hlth, S-41119 Gothenburg, Sweden.
[Reichenberg, Abraham] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
[Reichenberg, Abraham] Mt Sinai Sch Med, Dept Prevent Med, New York, NY USA.
[Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
RP Lundstrom, S (reprint author), Univ Gothenburg, Gillberg Neuropsychiat Ctr, Kungsgatan 12, S-41119 Gothenburg, Sweden.
EM sebastian.lundstrom@gnc.gu.se
FU Swedish Council for Working Life under the ALF; Soderstrom-Konigska
Foundation; Swedish Research Council (Medicine); Swedish Research
Council (SIMSAM)
FX The Child and Adolescent Twin Study in Sweden study was supported by the
Swedish Council for Working Life, funds under the ALF agreement, the
Soderstrom-Konigska Foundation, and the Swedish Research Council
(Medicine and SIMSAM). The current study received no specific funding.
The funding sources had no involvement in the study design; collection,
analysis, and interpretation of the data; or the decision to submit this
paper for publication.
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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World Health Organization, 1979, INT STAT CLASS DIS R
NR 44
TC 0
Z9 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD APR 28
PY 2015
VL 350
AR h1961
DI 10.1136/bmj.h1961
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CH3UM
UT WOS:000353955900003
PM 25922345
ER
PT J
AU Halford, B
AF Halford, Bethany
TI SMALL STEPS TOWARD AUTISM TREATMENTS
SO CHEMICAL & ENGINEERING NEWS
LA English
DT Article
NR 0
TC 0
Z9 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0009-2347
EI 1520-605X
J9 CHEM ENG NEWS
JI Chem. Eng. News
PD APR 27
PY 2015
VL 93
IS 17
BP 30
EP 31
PG 2
WC Chemistry, Multidisciplinary; Engineering, Chemical
SC Chemistry; Engineering
GA CG8XM
UT WOS:000353599000049
ER
PT J
AU Lopez, AJ
Wood, MA
AF Lopez, Alberto J.
Wood, Marcelo A.
TI Role of nucleosome remodeling in neurodevelopmental and intellectual
disability disorders
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Review
DE epigenetics; nucleosome remodeling; autism spectrum disorders (ASD);
intellectual disability; BAF53b; rubinstein-taybi syndrome; coffin-sins
syndrome; nicolaides-baraitser syndrome
ID RUBINSTEIN-TAYBI-SYNDROME; COFFIN-SIRIS SYNDROME; LONG-TERM-MEMORY;
HISTONE ACETYLTRANSFERASE ACTIVITY; DE-NOVO MUTATIONS; IFN-BETA
ENHANCEOSOME; YEAST HO GENE; SYNAPTIC PLASTICITY; RETT-SYNDROME;
MENTAL-RETARDATION
AB It is becoming increasingly important to understand how epigenetic mechanisms control gene expression during neurodevelopment. Two epigenetic mechanisms that have received considerable attention are DNA methylation and histone acetylation. Human exome sequencing and genome-wide association studies have linked several neurobiological disorders to genes whose products actively regulate DNA methylation and histone acetylation. More recently, a third major epigenetic mechanism, nucleosome remodeling, has been implicated in human developmental and intellectual disability (ID) disorders. Nucleosome remodeling is driven primarily through nucleosome remodeling complexes with specialized ATP-dependent enzymes. These enzymes directly interact with DNA or chromatin structure, as well as histone subunits, to restructure the shape and organization of nucleosome positioning to ultimately regulate gene expression. Of particular interest is the neuron-specific Brg 1/hBrm Associated Factor (nBAF) complex. Mutations in nBAF subunit genes have so far been linked to Coffin-Sins syndrome (CSS), Nicolaides-Baraitser syndrome (NBS), schizophrenia, and Autism Spectrum Disorder (ASD). Together, these human developmental and ID disorders are powerful examples of the impact of epigenetic modulation on gene expression. This review focuses on the new and emerging role of nucleosome remodeling in neurodevelopmental and ID disorders and whether nucleosome remodeling affects gene expression required for cognition independently of its role in regulating gene expression required for development.
C1 [Lopez, Alberto J.; Wood, Marcelo A.] Univ Calif Irvine, Dept Neurobiol & Behav, Ctr Neurobiol Learning & Memory, Irvine, CA 92697 USA.
RP Wood, MA (reprint author), Univ Calif Irvine, Dept Neurobiol & Behav, Qureshey Res Lab 301, Irvine, CA 92697 USA.
EM mwood@uci.edu
FU NIH [DA025922, MH101491, DA036984]; DOE GAANN [P200A120165]; MBRS-IMSD
[GM055246]
FX We would like to thank Christina R. Burgart and Dina P. Matheos for
critical feedback on the manuscript. This work was supported by NIH
grants to MW (DA025922; MH101491; DA036984) and training grant support
to AL (DOE GAANN P200A120165; MBRS-IMSD GM055246).
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NR 133
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD APR 23
PY 2015
VL 9
AR 100
DI 10.3389/fnbeh.2015.00100
PG 10
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CI2HK
UT WOS:000354566500001
PM 25954173
ER
PT J
AU Kaushik, G
Thomas, MA
Aho, KA
AF Kaushik, Gaurav
Thomas, Michael A.
Aho, Ken A.
TI Psychoactive pharmaceuticals as environmental contaminants may disrupt
highly inter-connected nodes in an Autism-associated protein-protein
interaction network
SO BMC BIOINFORMATICS
LA English
DT Article
ID SPECTRUM DISORDERS; EXPRESSION; EXPOSURE; MODELS; CELLS
AB Background: Most cases of idiopathic autism spectrum disorder (ASD) likely result from unknown environmental triggers in genetically susceptible individuals. These triggers may include maternal exposure of a fetus to minute concentrations of pharmaceuticals, such as carbamazepine (CBZ), venlafaxine (VNX) and fluoxetine (FLX).
Unmetabolized pharmaceuticals reach drinking water through a variety of routes, including ineffectively treated sewage. Previous studies in our laboratory examined the extent to which gene sets were enriched in minnow brains treated with pharmaceuticals. Here, we tested the hypothesis that genes in fish brains and human cell cultures, significantly enriched by pharmaceuticals, would have distinct characteristics in an ASD-associated protein interaction network. We accomplished this by comparing these groups using 10 network indices.
Results: A network of 7212 proteins and 33,461 interactions was generated. We found that network characteristics for enriched gene sets for particular pharmaceuticals were distinct from each other, and were different from non-enriched ASD gene sets. In particular, genes in fish brains, enriched by CBZ and VNX 1) had higher network importance than that in the overall network, and those enriched by FLX, and 2) were distinct from FLX and non-enriched ASD genes in multivariate network space. Similarly, genes in human cell cultures enriched by pharmaceutical mixtures (at environmental concentrations) and valproate (at clinical dosages) had similar network signatures, and had greater network importance than genes in the overall ASD network.
Conclusions: The results indicate that important gene sets in the ASD network are particularly susceptible to perturbation by pharmaceuticals at environmental concentrations.
C1 [Kaushik, Gaurav; Thomas, Michael A.; Aho, Ken A.] Idaho State Univ, Dept Biol Sci, Pocatello, ID 83209 USA.
RP Aho, KA (reprint author), Idaho State Univ, Dept Biol Sci, Stop 8007,921 S 8th Ave, Pocatello, ID 83209 USA.
EM ahoken@isu.edu
FU INBRE Program, NIH (National Center for Research Resources) [P20
RR016454]; University Research Council (URC) of Idaho State University;
INBRE Program, NIH Grant (national Institute of General Medical
Sciences) [P20 GM103408]
FX The authors thank Dr. Pete Hallock for providing the guidance for using
Cytoscape software for our study. Dr. Luobin Yang also assisted in
carrying out gene set enrichment analyses. We also thank Dr. Terry
Bowyer for providing his guidance in writing; Cheng Han Chung for
reviewing this manuscript. The project described was supported by the
INBRE Program, NIH Grant Nos. P20 RR016454 (National Center for Research
Resources) and P20 GM103408 (national Institute of General Medical
Sciences), and the University Research Council (URC) of Idaho State
University.
CR Aho K, 2014, ASBIO COLLECTION STA
Aho K, 2014, FDN APPL STAT BIOL U
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NR 41
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD APR 23
PY 2015
VL 16
SU 7
AR S3
DI 10.1186/1471-2105-16-S7-S3
PG 9
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
GA CH4BR
UT WOS:000353976600003
PM 25952302
ER
PT J
AU Golan, O
Sinai-Gavrilov, Y
Baron-Cohen, S
AF Golan, Ofer
Sinai-Gavrilov, Yana
Baron-Cohen, Simon
TI The Cambridge Mindreading Face-Voice Battery for Children (CAM-C):
complex emotion recognition in children with and without autism spectrum
conditions
SO Molecular Autism
LA English
DT Article
DE Emotion recognition; Complex emotions; Facial expressions; Prosody;
Theory of mind; Empathy; Autism spectrum conditions
ID HIGH-FUNCTIONING AUTISM; CAST CHILDHOOD ASPERGER; SCHOOL-AGE-CHILDREN;
FACIAL EXPRESSIONS; NORMAL ADULTS; DISORDERS; MIND; INDIVIDUALS;
PERCEPTION; ACCURACY
AB Background: Difficulties in recognizing emotions and mental states are central characteristics of autism spectrum conditions (ASC). However, emotion recognition (ER) studies have focused mostly on recognition of the six 'basic' emotions, usually using still pictures of faces.
Methods: This study describes a new battery of tasks for testing recognition of nine complex emotions and mental states from video clips of faces and from voice recordings taken from the Mindreading DVD. This battery (the Cambridge Mindreading Face-Voice Battery for Children or CAM-C) was given to 30 high-functioning children with ASC, aged 8 to 11, and to 25 matched controls.
Results: The ASC group scored significantly lower than controls on complex ER from faces and voices. In particular, participants with ASC had difficulty with six out of nine complex emotions. Age was positively correlated with all task scores, and verbal IQ was correlated with scores in the voice task. CAM-C scores were negatively correlated with parent-reported level of autism spectrum symptoms.
Conclusions: Children with ASC show deficits in recognition of complex emotions and mental states from both facial and vocal expressions. The CAM-C may be a useful test for endophenotypic studies of ASC and is one of the first to use dynamic stimuli as an assay to reveal the ER profile in ASC. It complements the adult version of the CAM Face-Voice Battery, thus providing opportunities for developmental assessment of social cognition in autism.
C1 [Golan, Ofer; Sinai-Gavrilov, Yana] Bar Ilan Univ, Dept Psychol, IL-5290002 Ramat Gan, Israel.
[Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 2AH, England.
[Baron-Cohen, Simon] Fulbourn Hosp, CLASS Clin, Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge CB21 5EF, England.
RP Golan, O (reprint author), Bar Ilan Univ, Dept Psychol, IL-5290002 Ramat Gan, Israel.
EM ofer.golan@biu.ac.il
FU Wingate Foundation; Corob Charitable Trust; B'nai B'rith Scholarships;
Shirley Foundation; Medical Research Council (MRC) UK; Wellcome Trust;
Autism Research Trust
FX OG was supported by the Wingate Foundation, the Corob Charitable Trust
and B'nai B'rith Scholarships. SBC was supported by the Shirley
Foundation, the Medical Research Council (MRC) UK, the Wellcome Trust
and the Autism Research Trust. This study was conducted in association
with the NIHR CLAHRC-EoE, EU ASC-Inclusion, and EU-AIMS. We would like
to thank the Wirral Autistic Society, Umbrella Autism Cambridgeshire,
the Hertfordshire Autistic Resource Centre, Brookside Family
Consultation Clinic, Mayfield Primary School and Kings Hedges Primary
School for their help with recruiting participants. We are grateful to
Jacqueline Hill, Chris Ashwin, Sally Wheelwright, Yael Golan, Sarah
Johnson and Emma Chapman for their help, and to Bhisma Chakrabarti for
valuable discussions.
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NR 73
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD APR 23
PY 2015
VL 6
AR 22
DI 10.1186/s13229-015-0018-z
PG 9
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CG9EK
UT WOS:000353617400001
PM 25932320
ER
PT J
AU Chen, J
Lin, MY
Hrabovsky, A
Pedrosa, E
Dean, J
Jain, S
Zheng, DY
Lachman, HM
AF Chen, Jian
Lin, Mingyan
Hrabovsky, Anastasia
Pedrosa, Erika
Dean, Jason
Jain, Swati
Zheng, Deyou
Lachman, Herbert M.
TI ZNF804A Transcriptional Networks in Differentiating Neurons Derived from
Induced Pluripotent Stem Cells of Human Origin
SO PLOS ONE
LA English
DT Article
ID MATERNAL IMMUNE ACTIVATION; GENOME-WIDE ASSOCIATION; AUTISM SPECTRUM
DISORDER; HISTOCOMPATIBILITY COMPLEX LOCUS; RISK GENE NEUREGULIN-1;
ALPHA-B-CRYSTALLIN; BIPOLAR DISORDER; PRENATAL INFECTION; CANDIDATE
GENES; NEURODEVELOPMENTAL PATHWAYS
AB ZNF804A (Zinc Finger Protein 804A) has been identified as a candidate gene for schizophrenia (SZ), autism spectrum disorders (ASD), and bipolar disorder (BD) in replicated genome wide association studies (GWAS) and by copy number variation (CNV) analysis. Although its function has not been well-characterized, ZNF804A contains a C2H2-type zinc-finger domain, suggesting that it has DNA binding properties, and consequently, a role in regulating gene expression. To further explore the role of ZNF804A on gene expression and its downstream targets, we used a gene knockdown (KD) approach to reduce its expression in neural progenitor cells (NPCs) derived from induced pluripotent stem cells (iPSCs). KD was accomplished by RNA interference (RNAi) using lentiviral particles containing shRNAs that target ZNF804A mRNA. Stable transduced NPC lines were generated after puromycin selection. A control cell line expressing a random (scrambled) shRNA was also generated. Neuronal differentiation was induced, RNA was harvested after 14 days and transcriptome analysis was carried out using RNA-seq. 1815 genes were found to be differentially expressed at a nominally significant level (p<0.05); 809 decreased in expression in the KD samples, while 1106 increased. Of these, 370 achieved genome wide significance (FDR<0.05); 125 were lower in the KD samples, 245 were higher. Pathway analysis showed that genes involved in interferon-signaling were enriched among those that were down-regulated in the KD samples. Correspondingly, ZNF804A KD was found to affect interferon-alpha 2 (IFNA2)-mediated gene expression. The findings suggest that ZNF804A may affect a differentiating neuron's response to inflammatory cytokines, which is consistent with models of SZ and ASD that support a role for infectious disease, and/or autoimmunity in a subgroup of patients.
C1 [Chen, Jian; Hrabovsky, Anastasia; Pedrosa, Erika; Dean, Jason; Jain, Swati; Lachman, Herbert M.] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10467 USA.
[Lin, Mingyan; Zheng, Deyou; Lachman, Herbert M.] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10467 USA.
[Zheng, Deyou; Lachman, Herbert M.] Albert Einstein Coll Med, Dominick Purpura Dept Neurosci, Bronx, NY 10467 USA.
[Zheng, Deyou] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA.
[Lachman, Herbert M.] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA.
RP Zheng, DY (reprint author), Albert Einstein Coll Med, Dept Genet, Bronx, NY 10467 USA.
EM Deyou.Zheng@einstein.yu.edu; Herb.Lachman@einstein.yu.edu
FU National Institute of Mental Health [MH073164, MH097893, MH099427,
MH087840]
FX This work was supported by the National Institute of Mental Health
(MH073164, MH097893, MH099427, and MH087840). The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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NR 166
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 23
PY 2015
VL 10
IS 4
DI 10.1371/journal.pone.0124597
PG 23
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CG5KZ
UT WOS:000353332000077
PM 25905630
ER
PT J
AU Liu, YF
Sowell, SM
Luo, Y
Chaubey, A
Cameron, RS
Kim, HG
Srivastava, AK
AF Liu, Ying F.
Sowell, Sarah M.
Luo, Yue
Chaubey, Alka
Cameron, Richard S.
Kim, Hyung-Goo
Srivastava, Anand K.
TI Autism and Intellectual Disability-Associated KIRREL3 Interacts with
Neuronal Proteins MAP1B and MYO16 with Potential Roles in
Neurodevelopment
SO PLOS ONE
LA English
DT Article
ID CELL-ADHESION; SPECTRUM DISORDERS; GENES; BRAIN; CASK; PHENOTYPE;
DELETION; MICE; SYNAPTOGENESIS; EXPRESSION
AB Cell-adhesion molecules of the immunoglobulin superfamily play critical roles in brain development, as well as in maintaining synaptic plasticity, the dysfunction of which is known to cause cognitive impairment. Recently dysfunction of KIRREL3, a synaptic molecule of the immunoglobulin superfamily, has been implicated in several neurodevelopmental conditions including intellectual disability, autism spectrum disorder, and in the neurocognitive delay associated with Jacobsen syndrome. However, the molecular mechanisms of its physiological actions remain largely unknown. Using a yeast two-hybrid screen, we found that the KIRREL3 extracellular domain interacts with brain expressed proteins MAP1B and MYO16 and its intracellular domain can potentially interact with ATP1B1, UFC1, and SHMT2. The interactions were confirmed by co-immunoprecipitation and colocalization analyses of proteins expressed in human embryonic kidney cells, mouse neuronal cells, and rat primary neuronal cells. Furthermore, we show KIRREL3 colocalization with the marker for the Golgi apparatus and synaptic vesicles. Previously, we have shown that KIRREL3 interacts with the X-linked intellectual disability associated synaptic scaffolding protein CASK through its cytoplasmic domain. In addition, we found a genomic deletion encompassing MAP1B in one patient with intellectual disability, microcephaly and seizures and deletions encompassing MYO16 in two unrelated patients with intellectual disability, autism and microcephaly. MAP1B has been previously implicated in synaptogenesis and is involved in the development of the actin-based membrane skeleton. MYO16 is expressed in hippocampal neurons and also indirectly affects actin cytoskeleton through its interaction with WAVE1 complex. We speculate KIRREL3 interacting proteins are potential candidates for intellectual disability and autism spectrum disorder. Moreover, our findings provide further insight into understanding the molecular mechanisms underlying the physiological action of KIRREL3 and its role in neurodevelopment.
C1 [Liu, Ying F.; Sowell, Sarah M.; Luo, Yue; Chaubey, Alka; Srivastava, Anand K.] Greenwood Genet Ctr, JC Self Res Inst Human Genet, Greenwood, SC 29646 USA.
[Srivastava, Anand K.] Clemson Univ, Dept Genet & Biochem, Clemson, SC USA.
[Cameron, Richard S.] Georgia Regents Univ, Dept Med, Augusta, GA USA.
[Kim, Hyung-Goo] Georgia Regents Univ, Dept OB GYN, Inst Mol Med & Genet, Augusta, GA USA.
RP Srivastava, AK (reprint author), Greenwood Genet Ctr, JC Self Res Inst Human Genet, Greenwood, SC 29646 USA.
EM anand@ggc.org
FU Eunice Kennedy Shriver National Institute of Child Health and Human
Development [R01-HD039331]
FX This work was supported by a grant from the Eunice Kennedy Shriver
National Institute of Child Health and Human Development (R01-HD039331
to A.K.S.).
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NR 40
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 22
PY 2015
VL 10
IS 4
AR e0123106
DI 10.1371/journal.pone.0123106
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CG5KV
UT WOS:000353331500042
PM 25902260
ER
PT J
AU Zylka, MJ
Simon, JM
Philpot, BD
AF Zylka, Mark J.
Simon, Jeremy M.
Philpot, Benjamin D.
TI Gene Length Matters in Neurons
SO NEURON
LA English
DT Editorial Material
ID AUTISM SPECTRUM DISORDER; LONG GENES; MOUSE; MUTATIONS
AB A recent study by Gabel et al. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (> 100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and transcriptional mechanisms in neurodevelopmental and neurodegenerative disorders.
C1 [Zylka, Mark J.; Simon, Jeremy M.; Philpot, Benjamin D.] Univ N Carolina, Carolina Inst Dev Disabil, UNC Neurosci Ctr, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA.
RP Zylka, MJ (reprint author), Univ N Carolina, Carolina Inst Dev Disabil, UNC Neurosci Ctr, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA.
EM zylka@med.unc.edu
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Zeisel A, 2015, SCIENCE, V347, P1138, DOI 10.1126/science.aaa1934
NR 16
TC 0
Z9 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD APR 22
PY 2015
VL 86
IS 2
BP 353
EP 355
DI 10.1016/j.neuron.2015.03.059
PG 3
WC Neurosciences
SC Neurosciences & Neurology
GA CG6KS
UT WOS:000353410000005
PM 25905808
ER
PT J
AU Lombardo, MV
Pierce, K
Eyler, LT
Barnes, CC
Ahrens-Barbeau, C
Solso, S
Campbell, K
Courchesne, E
AF Lombardo, Michael V.
Pierce, Karen
Eyler, Lisa T.
Barnes, Cindy Carter
Ahrens-Barbeau, Clelia
Solso, Stephanie
Campbell, Kathleen
Courchesne, Eric
TI Different Functional Neural Substrates for Good and Poor Language
Outcome in Autism
SO NEURON
LA English
DT Article
ID FOLLOW-UP; SPECTRUM DISORDER; ASPERGER-SYNDROME; BEHAVIORAL TREATMENT;
NEUROIMAGING DATA; TEMPORAL CORTEX; CHILDREN; SPEECH; ORGANIZATION;
TRAJECTORIES
AB Autism (ASD) is vastly heterogeneous, particularly in early language development. While ASD language trajectories in the first years of life are highly unstable, by early childhood these trajectories stabilize and are predictive of longer-term outcome. Early neural substrates that predict/precede such outcomes are largely unknown, but could have considerable translational and clinical impact. Pre-diagnosis fMRI response to speech in ASD toddlers with relatively good language outcome was highly similar to non-ASD comparison groups and robustly recruited language-sensitive superior temporal cortices. In contrast, language-sensitive superior temporal cortices were hypoactive in ASD toddlers with poor language outcome. Brain-behavioral relationships were atypically reversed in ASD, and a multimodal combination of pre-diagnostic clinical behavioral measures and speech-related fMRI response showed the most promise as an ASD prognosis classifier. Thus, before ASD diagnoses and outcome become clinically clear, distinct functional neuroimaging phenotypes are already present that can shed insight on an ASD toddler's later outcome.
C1 [Lombardo, Michael V.] Univ Cyprus, Dept Psychol, CY-1678 Nicosia, Cyprus.
[Lombardo, Michael V.] Univ Cyprus, Ctr Appl Neurosci, CY-1678 Nicosia, Cyprus.
[Lombardo, Michael V.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 8AH, England.
[Eyler, Lisa T.; Barnes, Cindy Carter; Ahrens-Barbeau, Clelia; Solso, Stephanie; Campbell, Kathleen; Courchesne, Eric] Univ Calif San Diego, Dept Neurosci, Autism Ctr Excellence, La Jolla, CA 92093 USA.
[Eyler, Lisa T.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92161 USA.
[Eyler, Lisa T.] VA San Diego Healthcare Syst, VISN Mental Illness Res Educ & Clin Ctr 22, San Diego, CA 92161 USA.
RP Lombardo, MV (reprint author), Univ Cyprus, Dept Psychol, 1 Panepistimiou Ave, CY-1678 Nicosia, Cyprus.
EM mvlombardo@gmail.com; ecourchesne@ucsd.edu
FU NIMH Autism Center of Excellence [P50-MH081755]; NIMH [R01-MH080134,
R01-MH036840]; NFAR; Jesus College, Cambridge; British Academy
FX This work was supported by NIMH Autism Center of Excellence grant
P50-MH081755 (E.C.), NIMH R01-MH080134 (K.P.), NFAR grant (K.P.), NIMH
R01-MH036840 (E.C.), and fellowships from Jesus College, Cambridge and
the British Academy (M.V.L.). We thank Richard Znamirowski, Maisi Mayo,
and Julia Young for help with data collection and Stuart Spendlove and
Melanie Weinfeld for assistance with clinical characterization of
subjects.
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NR 52
TC 0
Z9 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0896-6273
EI 1097-4199
J9 NEURON
JI Neuron
PD APR 22
PY 2015
VL 86
IS 2
BP 567
EP 577
DI 10.1016/j.neuron.2015.03.023
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA CG6KS
UT WOS:000353410000022
PM 25864635
ER
PT J
AU Heeney, J
AF Heeney, Joanne
TI Disability welfare reform and the chav threat: a reflection on social
class and 'contested disabilities'
SO DISABILITY & SOCIETY
LA English
DT Editorial Material
DE parenting; welfare; class; disability; autism; ADHD
ID CHILDREN; MOTHERS; PEOPLE
AB The recent UK media clash between Katie Hopkins and Katie Price in the reality TV show Celebrity Big Brother 2015 regarding Price's receipt of welfare benefits for her son, Harvey, has reopened old debates about welfare support for the so-called deserving and undeserving poor. Nowhere is this more evident than in the classed moralities of motherhood with the harshest criticisms aimed at the 'chav' poor and working-class families and their children whose lifestyles and moral respectability may be called into question for causing or even fabricating particular disabilities in the first place. Alongside these characterisations of parental deficits and immorality associated with working-class and poor parents, connections between 'invisible' disability, poverty and poor parenting continue.
C1 Univ Sheffield, Dept Sociol Studies, Sheffield, S Yorkshire, England.
RP Heeney, J (reprint author), Univ Sheffield, Dept Sociol Studies, Sheffield, S Yorkshire, England.
EM jbheeney1@sheffield.ac.uk
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NR 21
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0968-7599
EI 1360-0508
J9 DISABIL SOC
JI Disabil. Soc.
PD APR 21
PY 2015
VL 30
IS 4
BP 650
EP 653
DI 10.1080/09687599.2015.1026745
PG 4
WC Rehabilitation; Social Sciences, Interdisciplinary
SC Rehabilitation; Social Sciences - Other Topics
GA CI9VM
UT WOS:000355118200012
ER
PT J
AU Potrzeba, ER
Fein, D
Naigles, L
AF Potrzeba, Emily R.
Fein, Deborah
Naigles, Letitia
TI Investigating the shape bias in typically developing children and
children with autism spectrum disorders
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE shape bias; autism; word learning; intermodal preferential looking;
developmental disorders
ID PREFERENTIAL LOOKING PARADIGM; LANGUAGE-ACQUISITION; YOUNG-CHILDREN;
COMPREHENSION; ATTENTION; RELIANCE; ACCOUNT; OBJECTS; WORDS
AB Young typically developing (TD) children have been observed to utilize word learning strategies such as the noun bias and shape bias; these improve their efficiency in acquiring and categorizing novel terms. Children using the shape bias extend object labels to new objects of the same shape; thus, the shape bias prompts the categorization of object words based on the global characteristic of shape over local, discrete details. Individuals with autism spectrum disorders (ASDs) frequently attend to minor details of objects rather than their global structure. Therefore, children with ASD may not use shape bias to acquire new words. Previous research with children with ASD has provided evidence that they parallel TD children in showing a noun bias, but not a shape bias (Tek et al., 2008). However, this sample was small and individual and item differences were not investigated in depth. In an extension of Tek et al. (2008) with twice the sample size and a wider developmental timespan, we tested 32 children with ASD and 35 TD children in a longitudinal study across 20 months using the intermodal preferential looking paradigm. Children saw five triads of novel objects (target, shapematch, color-match) in both NoName and Name trials; those who looked longer at the shape-match during the Name trials than the NoName trials demonstrated a shape bias. The TD group showed a significant shape bias at all visits, beginning at 20 months of age while the language-matched ASD group did not show a significant shape bias at any visit. Within the ASD group, though, some children did show a shape bias; these children had larger vocabularies concurrently and longitudinally. Degree of shape bias elicitation varied by item, but did not seem related to perceptual complexity. We conclude that shape does not appear to be an organizing factor for word learning by children with ASD.
C1 [Potrzeba, Emily R.; Fein, Deborah; Naigles, Letitia] Univ Connecticut, Dept Psychol, Storrs, CT USA.
[Potrzeba, Emily R.] Univ N Carolina, Dept Allied Hlth Sci, Chapel Hill, NC 27599 USA.
RP Potrzeba, ER (reprint author), Univ N Carolina, Dept Allied Hlth Sci, Chapel Hill, NC 27599 USA.
EM emily_potrzeba@med.unc.edu
FU National Institute on Deafness and Other Communication Disorders grant
[R01 DC007428]; UCONN Summer Undergraduate Research Fund
FX This research was funded by a grant from the National Institute on
Deafness and Other Communication Disorders grant to LN (Grant number:
R01 DC007428) and by a UCONN Summer Undergraduate Research Fund
fellowship to EP. We extend our gratitude to Dr. Saime Tek for helping
to launch this line of research, to Rose Jaffery, Janina Piotroski, and
Andrea Tovar for assistance in data collection, and to the
undergraduates of the UConn Child Language Lab for their expert coding.
We appreciate the helpful feedback we received from attendants of IMFAR
2014 in Atlanta. Finally, we also thank the children and families who
participated in the study.
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NR 45
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD APR 21
PY 2015
VL 6
AR 446
DI 10.3389/fpsyg.2015.00446
PG 12
WC Psychology, Multidisciplinary
SC Psychology
GA CH0DZ
UT WOS:000353690600001
PM 25954219
ER
PT J
AU Badcock, NA
Preece, KA
de Wit, B
Glenn, K
Fieder, N
Thie, J
McArthur, G
AF Badcock, Nicholas A.
Preece, Kathryn A.
de Wit, Bianca
Glenn, Katharine
Fieder, Nora
Thie, Johnson
McArthur, Genevieve
TI Validation of the Emotiv EPOC EEG system for research quality auditory
event-related potentials in children
SO PEERJ
LA English
DT Article
DE EEG; ERP; Emotiv EPOC; Validation; Mismatchnegativity; MMN; Intraclass
correlation; Methods; Auditory odd-ball; Children
ID MISMATCH NEGATIVITY MMN; LANGUAGE IMPAIRMENT; EVOKED-POTENTIALS;
MATURATION; ADOLESCENCE; ERP; AUTISM
AB Background. Previous work has demonstrated that a commercial gaming electroencephalography (EEG) system, Emotiv EPOC, can be adjusted to provide valid auditory event-related potentials (ERPs) in adults that are comparable to ERPs recorded by a research-grade EEG system, Neuroscan. The aim of the current study was to determine if the same was true for children.
Method. An adapted Emotiv EPOC system and Neuroscan system were used to make simultaneous EEG recordings in nineteen 6-to 12-year-old children under "passive" and "active" listening conditions. In the passive condition, children were instructed to watch a silent DVD and ignore 566 standard (1,000 Hz) and 100 deviant (1,200 Hz) tones. In the active condition, they listened to the same stimuli, and were asked to count the number of `high' (i.e., deviant) tones.
Results. Intraclass correlations (ICCs) indicated that the ERP morphology recorded with the two systems was very similar for the P1, N1, P2, N2, and P3 ERP peaks (r =.82 to.95) in both passive and active conditions, and less so, though still strong, for mismatch negativity ERP component (MMN; r =.67 to.74). There were few differences between peak amplitude and latency estimates for the two systems.
Conclusions. An adapted EPOC EEG system can be used to index children's late auditory ERP peaks (i.e., P1, N1, P2, N2, P3) and theirMMNERP component.
C1 [Badcock, Nicholas A.; Preece, Kathryn A.; de Wit, Bianca; Fieder, Nora; McArthur, Genevieve] Macquarie Univ, ARC Ctr Excellence Cognit & Its Disorders, N Ryde, NSW, Australia.
[Badcock, Nicholas A.; Preece, Kathryn A.; de Wit, Bianca; Fieder, Nora; McArthur, Genevieve] Macquarie Univ, Dept Cognit Sci, N Ryde, NSW, Australia.
[Glenn, Katharine] MultiLit, Macquarie Pk, NSW, Australia.
[Thie, Johnson] Univ Sydney, Sch Elect & Informat Engn, Sydney, NSW 2006, Australia.
RP Badcock, NA (reprint author), Macquarie Univ, ARC Ctr Excellence Cognit & Its Disorders, N Ryde, NSW, Australia.
EM nicholas.badcock@mq.edu.au
FU ARC Centre of Excellence Grant [CE110001021]; NHMRC equipment grant
FX This research was supported by an ARC Centre of Excellence Grant
[CE110001021] and an NHMRC equipment grant. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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NR 23
TC 0
Z9 0
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD APR 21
PY 2015
VL 3
AR e907
DI 10.7717/peerj.907
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CH2DU
UT WOS:000353836500004
PM 25922794
ER
PT J
AU Sasaki, Y
Usami, M
Sasayama, D
Okada, T
Iwadare, Y
Watanabe, K
Ushijima, H
Tanaka, T
Harada, M
Tanaka, H
Kodaira, M
Sugiyama, N
Sawa, T
Saito, K
AF Sasaki, Yoshinori
Usami, Masahide
Sasayama, Daimei
Okada, Takashi
Iwadare, Yoshitaka
Watanabe, Kyota
Ushijima, Hirokage
Tanaka, Tetsuya
Harada, Maiko
Tanaka, Hiromi
Kodaira, Masaki
Sugiyama, Nobuhiro
Sawa, Tetsuji
Saito, Kazuhiko
TI Concerns Expressed by Parents of Children with Pervasive Developmental
Disorders for Different Time Periods of the Day: A Case-Control Study
SO PLOS ONE
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
DISORDER; OPPOSITIONAL DEFIANT; SYMPTOMS; AUTISM; RELIABILITY;
ATOMOXETINE; VALIDITY
AB Background/Aim
The Questionnaire: Children with Difficulties (QCD) is a parent-assessed questionnaire designed to evaluate child's difficulties in functioning during specific periods of the day. This study aimed to evaluate difficulties in daily functioning of children and adolescents with pervasive developmental disorder (PDD) using the QCD. Results were compared with those for a community sample.
Methods
A case-control design was used. The cases comprised elementary school students (182 males, 51 females) and junior high school students (100 males, 39 females) with PDD, whereas a community sample of elementary school students (568 males, 579 females) and junior high school students (180 males, 183 females) was enrolled as controls. Their behavior was assessed using the QCD, the Tokyo Autistic Behavior Scale (TABS), the ADHD-rating scale (ADHD-RS), and the Oppositional Defiant Behavior Inventory (ODBI) for elementary and junior high school students, respectively. Effects of gender and diagnosis on the QCD scores were analyzed. Correlation coefficients between QCD and TABS, ADHD-RS, and ODBI scores were analyzed.
Results
The QCD scores for the children with PDD were significantly lower compared with those from the community sample (P < 0.001). Significantly strong correlations were observed in more areas of the ADHD-RS and ODBI scores compared with the TABS scores.
Conclusions
Children with PDD experienced greater difficulties in completing basic daily activities; moreover, their QCD scores revealed stronger associations with their ADHD-RS and ODBI scores in comparison with their TABS scores. The difficulties of PDD, ADHD and OBDI symptoms combined in children makes it necessary to assess all diagnoses before any therapy for PDD is initiated in order to be able to evaluate its results properly.
C1 [Sasaki, Yoshinori; Usami, Masahide; Iwadare, Yoshitaka; Watanabe, Kyota; Ushijima, Hirokage; Tanaka, Tetsuya; Harada, Maiko; Tanaka, Hiromi] Kohnodai Hosp, Natl Ctr Global Hlth & Med, Dept Child & Adolescent Psychiat, Chiba, Japan.
[Sasayama, Daimei; Sugiyama, Nobuhiro] Shinshu Univ, Dept Psychiat, Matsumoto, Nagano 390, Japan.
[Okada, Takashi] Nagoya Univ, Grad Sch Med, Dept Child & Adolescent Psychiat, Nagoya, Aichi 4648601, Japan.
[Kodaira, Masaki; Saito, Kazuhiko] Aiiku Hosp, Aiiku Maternal & Child Hlth Ctr, Imperial Gift Fdn, Dept Child & Adolescent Mental Hlth, Tokyo, Japan.
[Sawa, Tetsuji] Kitasato Univ, Grad Sch Med Sci, Dept Dev Psychiat, Tokyo, Japan.
RP Sasaki, Y (reprint author), Kohnodai Hosp, Natl Ctr Global Hlth & Med, Dept Child & Adolescent Psychiat, Chiba, Japan.
EM lalala.ponyo@gmail.com
RI Sugiyama, Nobuhiro/C-6388-2008; Usami, Masahide/G-1404-2015
OI Usami, Masahide/0000-0002-1145-9971
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NR 21
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 21
PY 2015
VL 10
IS 4
AR e0124692
DI 10.1371/journal.pone.0124692
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CG3XJ
UT WOS:000353212600080
PM 25898260
ER
PT J
AU King, BH
AF King, Bryan H.
TI Promising Forecast for Autism Spectrum Disorders
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Editorial Material
ID MEASLES; MUMPS
C1 [King, Bryan H.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98145 USA.
[King, Bryan H.] Seattle Childrens Hosp, Seattle, WA 98145 USA.
RP King, BH (reprint author), Univ Washington, Seattle Childrens Autism Ctr, POB 5371-M1-1, Seattle, WA 98145 USA.
EM bryan.king@seattlechildrens.org
CR Bearss K, 2015, JAMA-J AM MED ASSOC, V313, P1524, DOI 10.1001/jama.2015.3150
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NR 15
TC 0
Z9 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD APR 21
PY 2015
VL 313
IS 15
BP 1518
EP 1519
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA CG3SA
UT WOS:000353198700014
PM 25898047
ER
PT J
AU Bearss, K
Johnson, C
Smith, T
Lecavalier, L
Swiezy, N
Aman, M
McAdam, DB
Butter, E
Stillitano, C
Minshawi, N
Sukhodolsky, DG
Mruzek, DW
Turner, K
Neal, T
Hallett, V
Mulick, JA
Green, B
Handen, B
Deng, YH
Dziura, J
Scahill, L
AF Bearss, Karen
Johnson, Cynthia
Smith, Tristram
Lecavalier, Luc
Swiezy, Naomi
Aman, Michael
McAdam, David B.
Butter, Eric
Stillitano, Charmaine
Minshawi, Noha
Sukhodolsky, Denis G.
Mruzek, Daniel W.
Turner, Kylan
Neal, Tiffany
Hallett, Victoria
Mulick, James A.
Green, Bryson
Handen, Benjamin
Deng, Yanhong
Dziura, James
Scahill, Lawrence
TI Effect of Parent Training vs Parent Education on Behavioral Problems in
Children With Autism Spectrum Disorder A Randomized Clinical Trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID PERVASIVE DEVELOPMENTAL DISORDERS; YOUNG-CHILDREN; PROGRAM;
INTERVENTION; RISPERIDONE; CHECKLIST; STRESS; IMPACT
AB IMPORTANCE Disruptive behavior is common in children with autism spectrum disorder. Behavioral interventions are used to treat disruptive behavior but have not been evaluated in large-scale randomized trials.
OBJECTIVE To evaluate the efficacy of parent training for children with autism spectrum disorder and disruptive behavior.
DESIGN, SETTING, AND PARTICIPANTS This 24-week randomized trial compared parent training (n = 89) to parent education (n = 91) at 6 centers (Emory University, Indiana University, Ohio State University, University of Pittsburgh, University of Rochester, Yale University). We screened 267 children; 180 children (aged 3-7 years) with autism spectrum disorder and disruptive behaviors were randomly assigned (86% white, 88% male) between September 2010 and February 2014.
INTERVENTIONS Parent training (11 core, 2 optional sessions; 2 telephone boosters; 2 home visits) provided specific strategies to manage disruptive behavior. Parent education (12 core sessions, 1 home visit) provided information about autism but no behavior management strategies.
MAIN OUTCOMES AND MEASURES Parents rated disruptive behavior and noncompliance on co-primary outcomes: the Aberrant Behavior Checklist-Irritability subscale (range, 0-45) and the Home Situations Questionnaire-Autism Spectrum Disorder (range, 0-9). On both measures, higher scores indicate greater severity and a 25% reduction indicates clinical improvement. A clinician blind to treatment assignment rated the Improvement scale of the Clinical Global Impression (range, 1-7), a secondary outcome, with a positive response less than 3.
RESULTS At week 24, the Aberrant Behavior Checklist-Irritability subscale declined 47.7% in parent training (from 23.7 to 12.4) compared with 31.8% for parent education (23.9 to 16.3) (treatment effect, -3.9; 95% CI, -6.2 to -1.7; P < .001, standardized effect size = 0.62). The Home Situations Questionnaire-Autism Spectrum Disorder declined 55% (from 4.0 to 1.8) compared with 34.2% in parent education (3.8 to 2.5) (treatment effect, -0.7; 95% CI, -1.1 to -0.3; P < .001, standardized effect size = 0.45). Neither measure met the prespecified minimal clinically important difference. The proportions with a positive response on the Clinical Global Impression-Improvement scale were 68.5% for parent training vs 39.6% for parent education (P < .001).
CONCLUSIONS AND RELEVANCE For children with autism spectrum disorder, a 24-week parent training program was superior to parent education for reducing disruptive behavior on parent-reported outcomes, although the clinical significance of the improvement is unclear. The rate of positive response judged by a blinded clinician was greater for parent training vs parent education.
C1 [Bearss, Karen; Green, Bryson; Scahill, Lawrence] Childrens Healthcare Atlanta, Marcus Autism Ctr, Dept Pediat, Atlanta, GA 30329 USA.
[Bearss, Karen; Green, Bryson; Scahill, Lawrence] Emory Univ, Atlanta, GA 30329 USA.
[Johnson, Cynthia; Stillitano, Charmaine] Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA.
[Smith, Tristram; McAdam, David B.; Mruzek, Daniel W.] Univ Rochester, Dept Pediat, Rochester, NY USA.
[Lecavalier, Luc; Aman, Michael] Ohio State Univ, Nisonger Ctr, UCEDD, Dept Psychol, Columbus, OH 43210 USA.
[Lecavalier, Luc; Aman, Michael] Ohio State Univ, Nisonger Ctr, UCEDD, Dept Psychiat, Columbus, OH 43210 USA.
[Swiezy, Naomi; Minshawi, Noha; Neal, Tiffany] Indiana Univ, Dept Psychiat, Indianapolis, IN 46204 USA.
[Butter, Eric; Mulick, James A.] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA.
[Butter, Eric; Mulick, James A.] Natl Childrens Hosp, Columbus, OH USA.
[Sukhodolsky, Denis G.] Yale Univ, Ctr Child Study, New Haven, CT 06520 USA.
[Turner, Kylan] Arizona State Univ, Mary Lou Fulton Teachers Coll, Div Educ Leadership & Innovat, Tempe, AZ USA.
[Hallett, Victoria] Kings Coll London, Dept Psychol, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England.
[Handen, Benjamin] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
[Deng, Yanhong] Yale Univ, Sch Publ Hlth, New Haven, CT USA.
[Dziura, James] Yale Univ, Dept Emergency Med, New Haven, CT USA.
RP Scahill, L (reprint author), Childrens Healthcare Atlanta, Marcus Autism Ctr, 1920 Briarcliff NE, Atlanta, GA 30329 USA.
EM lawrence.scahill@emory.edu
FU National Institute of Mental Health [MH081148, MH080965, MH081105,
MH081221, MH080906]; University of Rochester from the National Center
for Advancing Translational Sciences of the National Institutes of
Health (NIH) [UL1 TR000042]; National Center for Research Resources
(NCRR), a component of the NIH [UL1 RR024139, 5KL2RR024138]; NIH Roadmap
for Medical Research; Public Health Service grant from the CTSA program
of the NIH NCRR at Emory University School of Medicine [UL1 RR025008];
Marcus Foundation; Joseph B. Whitehead Foundation; Children's Healthcare
of Atlanta Foundation; Cox Foundation; [MH079130]
FX This work was funded by the National Institute of Mental Health by
grants to Yale University/Emory University (MH081148; principal
investigator: Dr Scahill), the University of Pittsburgh (MH080965;
principal investigator: Dr Johnson), Ohio State University (MH081105;
principal investigator: Dr Lecavalier), Indiana University (MH081221;
principal investigator: Dr Swiezy), and the University of Rochester
(MH080906; principal investigator: Dr Smith). The project described in
this publication also was supported by MH079130 (principal investigator:
Dr Sukhodolsky); a University of Rochester Clinical and Translational
Scholar Award (CTSA) (UL1 TR000042) from the National Center for
Advancing Translational Sciences of the National Institutes of Health
(NIH); a CTSA (UL1 RR024139) and grant from the National Center for
Research Resources (NCRR) (5KL2RR024138), a component of the NIH; and
the NIH Roadmap for Medical Research. This work was supported in part by
a Public Health Service grant (UL1 RR025008) from the CTSA program of
the NIH NCRR at Emory University School of Medicine and also supported
by the Marcus Foundation, Joseph B. Whitehead Foundation, Children's
Healthcare of Atlanta Foundation, and Cox Foundation.
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NR 27
TC 1
Z9 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD APR 21
PY 2015
VL 313
IS 15
BP 1524
EP 1533
DI 10.1001/jama.2015.3150
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA CG3SA
UT WOS:000353198700017
PM 25898050
ER
PT J
AU Jain, A
Marshall, J
Buikema, A
Bancroft, T
Kelly, JP
Newschaffer, CJ
AF Jain, Anjali
Marshall, Jaclyn
Buikema, Ami
Bancroft, Tim
Kelly, Jonathan P.
Newschaffer, Craig J.
TI Autism Occurrence by MMR Vaccine Status Among US Children With Older
Siblings With and Without Autism
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID SPECTRUM DISORDERS; SAFETY CONCERNS; MEASLES; RECURRENCE; MUMPS; RISK
AB IMPORTANCE Despite research showing no link between the measles-mumps-rubella (MMR) vaccine and autism spectrum disorders (ASD), beliefs that the vaccine causes autism persist, leading to lower vaccination levels. Parents who already have a child with ASD may be especially wary of vaccinations.
OBJECTIVE To report ASD occurrence by MMR vaccine status in a large sample of US children who have older siblings with and without ASD.
DESIGN, SETTING, AND PARTICIPANTS A retrospective cohort study using an administrative claims database associated with a large commercial health plan. Participants included children continuously enrolled in the health plan from birth to at least 5 years of age during 2001-2012 who also had an older sibling continuously enrolled for at least 6 months between 1997 and 2012.
EXPOSURES MMR vaccine receipt (0, 1, 2 doses) between birth and 5 years of age.
MAIN OUTCOMES AND MEASURES ASD status defined as 2 claims with a diagnosis code in any position for autistic disorder or other specified pervasive developmental disorder (PDD) including Asperger syndrome, or unspecified PDD (International Classification of Diseases, Ninth Revision, Clinical Modification 299.0x, 299.8x, 299.9x).
RESULTS Of 95 727 children with older siblings, 994 (1.04%) were diagnosed with ASD and 1929 (2.01%) had an older sibling with ASD. Of those with older siblings with ASD, 134 (6.9%) had ASD, vs 860 (0.9%) children with unaffected siblings (P < .001). MMR vaccination rates (>= 1 dose) were 84%(n = 78 564) at age 2 years and 92%(n = 86 063) at age 5 years for children with unaffected older siblings, vs 73%(n = 1409) at age 2 years and 86%(n = 1660) at age 5 years for children with affected siblings. MMR vaccine receipt was not associated with an increased risk of ASD at any age. For children with older siblings with ASD, at age 2, the adjusted relative risk (RR) of ASD for 1 dose of MMR vaccine vs no vaccine was 0.76 (95% CI, 0.49-1.18; P = .22), and at age 5, the RR of ASD for 2 doses compared with no vaccine was 0.56 (95% CI, 0.31-1.01; P = .052). For children whose older siblings did not have ASD, at age 2, the adjusted RR of ASD for 1 dose was 0.91 (95% CI, 0.67-1.20; P = .50) and at age 5, the RR of ASD for 2 doses was 1.12 (95% CI, 0.78-1.59; P = .55).
CONCLUSIONS AND RELEVANCE In this large sample of privately insured children with older siblings, receipt of the MMR vaccine was not associated with increased risk of ASD, regardless of whether older siblings had ASD. These findings indicate no harmful association between MMR vaccine receipt and ASD even among children already at higher risk for ASD.
C1 [Jain, Anjali; Marshall, Jaclyn; Kelly, Jonathan P.] Lewin Grp, Falls Church, VA 22042 USA.
[Buikema, Ami; Bancroft, Tim] Optum, Eden Prairie, MN USA.
[Newschaffer, Craig J.] Drexel Univ, AJ Drexel Autism Inst, Philadelphia, PA 19104 USA.
RP Jain, A (reprint author), Lewin Grp, 3130 Fairview Pk Dr,Ste SOO, Falls Church, VA 22042 USA.
EM anjali.jain@lewin.com
FU National Institute of Mental Health, National Institutes of Health; US
Department of Health and Human Services [HHSN-271-2010-00033-C]
FX This project was funded by the National Institute of Mental Health,
National Institutes of Health, and the US Department of Health and Human
Services under contract HHSN-271-2010-00033-C.
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NR 27
TC 0
Z9 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD APR 21
PY 2015
VL 313
IS 15
BP 1534
EP 1540
DI 10.1001/jama.2015.3077
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CG3SA
UT WOS:000353198700018
PM 25898051
ER
PT J
AU Segel, R
Ben-Pazi, H
Zeligson, S
Fatal-Valevski, A
Aran, A
Gross-Tsur, V
Schneebaum-Sender, N
Shmueli, D
Lev, D
Perlberg, S
Blumkin, L
Deutsch, L
Levy-Lahad, E
AF Segel, Reeval
Ben-Pazi, Hilla
Zeligson, Sharon
Fatal-Valevski, Aviva
Aran, Adi
Gross-Tsur, Varda
Schneebaum-Sender, Nira
Shmueli, Dorit
Lev, Dorit
Perlberg, Shira
Blumkin, Luba
Deutsch, Lisa
Levy-Lahad, Ephrat
TI Copy number variations in cryptogenic cerebral palsy
SO NEUROLOGY
LA English
DT Article
ID FUNCTION CLASSIFICATION-SYSTEM; AUTISM SPECTRUM DISORDERS; CHROMOSOMAL
MICROARRAY; GENE; INDIVIDUALS; DISABILITY; EPILEPSY; CHILDREN; FEATURES;
DELETION
AB Objective:To determine the prevalence and characteristics of copy number variations (CNVs) in children with cerebral palsy (CP) of unknown etiology, comprising approximately 20% of the CP population.Methods:Fifty-two participants (age 10.5 7.8 years; Gross Motor Function Classification System scale 2.8 1.3) with nonprogressive pyramidal and/or extrapyramidal signs since infancy and no identified etiology were enrolled. Individuals with evidence of acquired causes were excluded. Participants underwent neurologic and clinical genetic examinations before the genomic testing. Chromosomal microarray analysis to detect CNVs was performed using the Affymetrix platform. CNVs identified were classified as pathogenic, likely pathogenic, likely benign, or benign. Only pathogenic and likely pathogenic CNVs were defined as clinically significant.Results:Thirty-nine CNVs were found in 25 of 52 participants (48%). Sixteen participants (31%) had clinically significant CNVs: 10 pathogenic and 6 likely pathogenic, of which 7 were not previously associated with motor disability. Nine participants had likely benign CNVs. Clinically significant CNVs were more frequently de novo (12/16; p < 0.001) including in 5 of 8 individuals who had a first- or second-degree relative with a major neurologic disorder. Dysmorphic features and nonmotor comorbidities were more prevalent in individuals with clinically significant CNVs (p < 0.05 for both).Conclusion:CNVs, most frequently de novo, are common in individuals with cryptogenic CP. We recommend CNV testing in individuals with CP of unknown etiology.
C1 [Segel, Reeval; Zeligson, Sharon; Perlberg, Shira; Levy-Lahad, Ephrat] Shaare Zedek Med Ctr, Inst Med Genet, Jerusalem, Israel.
[Ben-Pazi, Hilla; Aran, Adi; Gross-Tsur, Varda] Shaare Zedek Med Ctr, Neuropediat Unit, Jerusalem, Israel.
[Fatal-Valevski, Aviva; Schneebaum-Sender, Nira] Tel Aviv Med Ctr & Sch Med, Dana Childrens Hosp, Pediat Neurol Unit, IL-64239 Tel Aviv, Israel.
[Shmueli, Dorit] Clalit, Jerusalem Child Dev Ctr, Jerusalem, Israel.
[Lev, Dorit; Blumkin, Luba] Wolfson Med Ctr, Metab Neurogenet Clin, Holon, Israel.
[Deutsch, Lisa] Biostat Consulting, BioStats, Haifa, Israel.
RP Segel, R (reprint author), Shaare Zedek Med Ctr, Inst Med Genet, Jerusalem, Israel.
EM reevals@szmc.org.il
FU MOF Joint Israel Ministry of Health [3-6185]; Hebrew University; Shaare
Zedek Medical Center
FX Supported by grants: MOF Joint Israel Ministry of Health grant (3-6185),
and the joint research fund of The Hebrew University and Shaare Zedek
Medical Center.
CR Arner M, 2008, J HAND SURG-AM, V33A, P1337, DOI 10.1016/j.jhsa.2008.02.032
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NR 28
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0028-3878
EI 1526-632X
J9 NEUROLOGY
JI Neurology
PD APR 21
PY 2015
VL 84
IS 16
BP 1660
EP 1668
DI 10.1212/WNL.0000000000001494
PG 9
WC Clinical Neurology
SC Neurosciences & Neurology
GA CG4GJ
UT WOS:000353243200012
PM 25817843
ER
PT J
AU Bilek, E
Ruf, M
Schafer, A
Akdeniz, C
Calhoun, VD
Schmahl, C
Demanuele, C
Tost, H
Kirsch, P
Meyer-Lindenberg, A
AF Bilek, Edda
Ruf, Matthias
Schaefer, Axel
Akdeniz, Ceren
Calhoun, Vince D.
Schmahl, Christian
Demanuele, Charmaine
Tost, Heike
Kirsch, Peter
Meyer-Lindenberg, Andreas
TI Information flow between interacting human brains: Identification,
validation, and relationship to social expertise
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE fMRI; hyperscanning; joint attention
ID INDEPENDENT COMPONENT ANALYSIS; RIGHT TEMPOROPARIETAL JUNCTION; JOINT
ATTENTION; NETWORK SIZE; FMRI DATA; COGNITION; METAANALYSIS;
COMMUNICATION; ACTIVATION; AUTISM
AB Social interactions are fundamental for human behavior, but the quantification of their neural underpinnings remains challenging. Here, we used hyperscanning functional MRI (fMRI) to study information flow between brains of human dyads during real-time social interaction in a joint attention paradigm. In a hardware setup enabling immersive audiovisual interaction of subjects in linked fMRI scanners, we characterize cross-brain connectivity components that are unique to interacting individuals, identifying information flow between the sender's and receiver's temporoparietal junction. We replicate these findings in an independent sample and validate our methods by demonstrating that cross-brain connectivity relates to a key real-world measure of social behavior. Together, our findings support a central role of human-specific cortical areas in the brain dynamics of dyadic interactions and provide an approach for the noninvasive examination of the neural basis of healthy and disturbed human social behavior with minimal a priori assumptions.
C1 [Bilek, Edda; Schaefer, Axel; Akdeniz, Ceren; Demanuele, Charmaine; Tost, Heike; Meyer-Lindenberg, Andreas] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
[Ruf, Matthias] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Neuroimaging, D-68159 Mannheim, Germany.
[Schmahl, Christian] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychosomat Med & Psychotherapy, D-68159 Mannheim, Germany.
[Kirsch, Peter] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Clin Psychol, D-68159 Mannheim, Germany.
[Calhoun, Vince D.] Mind Res Network, Albuquerque, NM 87131 USA.
[Calhoun, Vince D.] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA.
RP Meyer-Lindenberg, A (reprint author), Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
EM a.meyer-lindenberg@zi-mannheim.de
FU German Research Foundation (DFG) [SFB 636]; European Community
[HEALTH-F2-2010-241909]; DFG (Clinical Research Unit 256) [ME 1591/4-1];
German Federal Ministry of Education and Research [BMBF 01GQ1102]
FX The authors thank Dr. Emanuel Schwarz for his valuable comments on the
analysis and manuscript. E.B. is a PhD grant awardee of the SFB 636
International Graduate Program in Translational Neuroscience funded by
the German Research Foundation (DFG). A.M.-L. gratefully acknowledges
grant support by European Community's Seventh Framework Programme under
Grant HEALTH-F2-2010-241909 (Project EU-GEI). A.M.-L., P.K., and C.S.
gratefully acknowledge grant support by DFG (Clinical Research Unit 256,
ME 1591/4-1). H.T. gratefully acknowledges grant support by the German
Federal Ministry of Education and Research (BMBF 01GQ1102).
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NR 45
TC 0
Z9 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 21
PY 2015
VL 112
IS 16
BP 5207
EP 5212
DI 10.1073/pnas.1421831112
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CG4FJ
UT WOS:000353239100088
PM 25848050
ER
PT J
AU Koeda, M
Watanabe, A
Tsuda, K
Matsumoto, M
Ikeda, Y
Kim, W
Tateno, A
Naing, BT
Karibe, H
Shimada, T
Suzuki, H
Matsuura, M
Okubo, Y
AF Koeda, Michihiko
Watanabe, Atsushi
Tsuda, Kumiko
Matsumoto, Miwako
Ikeda, Yumiko
Kim, Woochan
Tateno, Amane
Naing, Banyar Than
Karibe, Hiroyuki
Shimada, Takashi
Suzuki, Hidenori
Matsuura, Masato
Okubo, Yoshiro
TI Interaction effect between handedness and CNTNAP2 polymorphism
(rs7794745 genotype) on voice-specific frontotemporal activity in
healthy individuals: an fMRI study
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE CNTNAP2; fMRI; voice; handedness; SNPs; autism; schizophrenia
ID AUTISM SPECTRUM DISORDER; LANGUAGE-RELATED REGIONS; CHINESE HAN
POPULATION; HUMAN AUDITORY-CORTEX; FUNCTIONAL MRI; HUMAN BRAIN; CEREBRAL
LATERALITY; GENETIC-VARIATION; SCHIZOPHRENIA; ASSOCIATION
AB Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: (1) rs7794745 (A/A or A/T), (2) rs2710102 [G/G or A carrier (A/G and A/A)], and (3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals.
C1 [Koeda, Michihiko; Kim, Woochan; Tateno, Amane; Okubo, Yoshiro] Nippon Med Sch, Grad Sch Med, Dept Neuropsychiat, Tokyo 1138603, Japan.
[Watanabe, Atsushi; Naing, Banyar Than] Nippon Med Coll Hosp, Div Personalized Genet Med, Tokyo, Japan.
[Watanabe, Atsushi; Naing, Banyar Than; Shimada, Takashi] Nippon Med Sch, Grad Sch Med, Dept Biochem & Mol Biol, Tokyo 1138603, Japan.
[Tsuda, Kumiko; Matsumoto, Miwako; Matsuura, Masato] Tokyo Med & Dent Univ, Dept Biofunct Informat, Tokyo, Japan.
[Ikeda, Yumiko; Karibe, Hiroyuki] Nippon Dent Univ Tokyo, Dept Pediat Dent, Tokyo, Japan.
[Suzuki, Hidenori] Nippon Med Sch, Grad Sch Med, Dept Pharmacol, Tokyo 1138603, Japan.
RP Koeda, M (reprint author), Nippon Med Sch, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan.
EM mkoeda@nms.ac.jp
FU Health and Labor Sciences Research Grant for Research on Psychiatric and
Neurological Diseases and Mental Health from Japanese Ministry of
Health, Labor and Welfare [H23-seishin-ippan-002]
FX We gratefully acknowledge the staff of Yaesu Clinic, Nippon Medical
School Hospital; Section of Biofunctional Informatics, Tokyo Medical and
Dental University; and Voice Neurocognition Laboratory, University of
Glasgow. This work was supported by a Health and Labor Sciences Research
Grant for Research on Psychiatric and Neurological Diseases and Mental
Health (H23-seishin-ippan-002) from the Japanese Ministry of Health,
Labor and Welfare.
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NR 64
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD APR 20
PY 2015
VL 9
AR 87
DI 10.3389/fnbeh.2015.00087
PG 13
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CI2GX
UT WOS:000354565000001
PM 25941478
ER
PT J
AU Grier, MD
Carson, RP
Lagrange, AH
AF Grier, Mark D.
Carson, Robert P.
Lagrange, Andre Hollis
TI Toward a Broader View of Ube3a in a Mouse Model of Angelman Syndrome:
Expression in Brain, Spinal Cord, Sciatic Nerve and Glial Cells
SO PLOS ONE
LA English
DT Article
ID UBIQUITIN LIGASE; WHITE-MATTER; AUTISM; REVEALS; NEURONS; GENE
AB Angelman Syndrome (AS) is a devastating neurodevelopmental disorder characterized by developmental delay, speech impairment, movement disorder, sleep disorders and refractory epilepsy. AS is caused by loss of the Ube3a protein encoded for by the imprinted Ube3a gene. Ube3a is expressed nearly exclusively from the maternal chromosome in mature neurons. While imprinting in neurons of the brain has been well described, the imprinting and expression of Ube3a in other neural tissues remains relatively unexplored. Moreover, given the overwhelming deficits in brain function in AS patients, the possibility of disrupted Ube3a expression in the infratentorial nervous system and its consequent disability have been largely ignored. We evaluated the imprinting status of Ube3a in the spinal cord and sciatic nerve and show that it is also imprinted in these neural tissues. Furthermore, a growing body of clinical and radiological evidence has suggested that myelin dysfunction may contribute to morbidity in many neurodevelopmental syndromes. However, findings regarding Ube3a expression in non-neuronal cells of the brain have varied. Utilizing enriched primary cultures of oligodendrocytes and astrocytes, we show that Ube3a is expressed, but not imprinted in these cell types. Unlike many other neurodevelopmental disorders, AS symptoms do not become apparent until roughly 6 to 12 months of age. To determine the temporal expression pattern and silencing, we analyzed Ube3a expression in AS mice at several time points. We confirm relaxed imprinting of Ube3a in neurons of the postnatal developing cortex, but not in structures in which neurogenesis and migration are more complete. This furthers the hypothesis that the apparently normal window of development in AS patients is supported by an incompletely silenced paternal allele in developing neurons, resulting in a relative preservation of Ube3a expression during this crucial epoch of early development.
C1 [Grier, Mark D.; Carson, Robert P.; Lagrange, Andre Hollis] Vanderbilt Univ, Med Ctr, Dept Neurol, Nashville, TN 37232 USA.
[Carson, Robert P.] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA.
[Lagrange, Andre Hollis] Tennessee Valley Vet Adm, Dept Neurol, Nashville, TN 37212 USA.
RP Lagrange, AH (reprint author), Vanderbilt Univ, Med Ctr, Dept Neurol, Nashville, TN 37232 USA.
EM Andre.H.Lagrange@vanderbilt.edu
FU Vanderbilt Kennedy Center [VA 1I01BX001189]; National Institute of
Neurological Disorders and Stroke; NIH [5K08NS050484]
FX This research was supported by a Hobbs Discovery Grant from the
Vanderbilt Kennedy Center and VA 1I01BX001189 to AHL and the National
Institute of Neurological Disorders and Stroke; NIH (5K08NS050484) to
RPC. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
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NR 31
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 20
PY 2015
VL 10
IS 4
DI 10.1371/journal.pone.0124649
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CG3XA
UT WOS:000353211700112
PM 25894543
ER
PT J
AU Sharma, R
Agarwal, A
Rohra, VK
Assidi, M
Abu-Elmagd, M
Turki, RF
AF Sharma, Rakesh
Agarwal, Ashok
Rohra, Vikram K.
Assidi, Mourad
Abu-Elmagd, Muhammad
Turki, Rola F.
TI Effects of increased paternal age on sperm quality, reproductive outcome
and associated epigenetic risks to offspring
SO REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
LA English
DT Review
DE Paternal age; Infertility; Semen parameters; Reproduction; Genetics;
Sperm DNA damage; Telomere length; Aneuploidy; Epigenetics; Offspring;
Assisted reproductive techniques
ID DE-NOVO MUTATIONS; CHROMATIN-STRUCTURE ASSAY; LEUKOCYTE TELOMERE LENGTH;
IN-VITRO FERTILIZATION; LOW-BIRTH-WEIGHT; FOLLICLE-STIMULATING-HORMONE;
EJACULATED HUMAN SPERMATOZOA; AUTISM SPECTRUM DISORDERS;
POPULATION-BASED COHORT; DNA-DAMAGE
AB Over the last decade, there has been a significant increase in average paternal age when the first child is conceived, either due to increased life expectancy, widespread use of contraception, late marriages and other factors. While the effect of maternal ageing on fertilization and reproduction is well known and several studies have shown that women over 35 years have a higher risk of infertility, pregnancy complications, spontaneous abortion, congenital anomalies, and perinatal complications. The effect of paternal age on semen quality and reproductive function is controversial for several reasons. First, there is no universal definition for advanced paternal ageing. Secondly, the literature is full of studies with conflicting results, especially for the most common parameters tested. Advancing paternal age also has been associated with increased risk of genetic disease. Our exhaustive literature review has demonstrated negative effects on sperm quality and testicular functions with increasing paternal age. Epigenetics changes, DNA mutations along with chromosomal aneuploidies have been associated with increasing paternal age. In addition to increased risk of male infertility, paternal age has also been demonstrated to impact reproductive and fertility outcomes including a decrease in IVF/ICSI success rate and increasing rate of preterm birth. Increasing paternal age has shown to increase the incidence of different types of disorders like autism, schizophrenia, bipolar disorders, and childhood leukemia in the progeny. It is thereby essential to educate the infertile couples on the disturbing links between increased paternal age and rising disorders in their offspring, to better counsel them during their reproductive years.
C1 [Sharma, Rakesh; Agarwal, Ashok; Rohra, Vikram K.] Cleveland Clin, Ctr Reprod Med, Cleveland, OH 44106 USA.
[Assidi, Mourad; Abu-Elmagd, Muhammad] King Abdulaziz Univ, Ctr Excellence Genom Med Res, Jeddah 21413, Saudi Arabia.
[Assidi, Mourad; Abu-Elmagd, Muhammad; Turki, Rola F.] King Abdulaziz Univ, KACST Technol Innovat Ctr Personalized Med, Jeddah 21413, Saudi Arabia.
[Turki, Rola F.] King Abdulaziz Univ Hosp, Dept Obstet & Gynecol, Jeddah, Saudi Arabia.
RP Agarwal, A (reprint author), Cleveland Clin, Ctr Reprod Med, Cleveland, OH 44106 USA.
EM agarwaa@ccf.org
FU Center for Reproductive Medicine, Cleveland Clinic
FX The authors are grateful to Amy Moore for editorial assistance. This
study was supported by funding from the Center for Reproductive
Medicine, Cleveland Clinic.
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NR 286
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1477-7827
J9 REPROD BIOL ENDOCRIN
JI Reprod. Biol. Endocrinol.
PD APR 19
PY 2015
VL 13
AR 35
DI 10.1186/s12958-015-0028-x
PG 20
WC Endocrinology & Metabolism; Reproductive Biology
SC Endocrinology & Metabolism; Reproductive Biology
GA CI6IP
UT WOS:000354862700001
PM 25928123
ER
PT J
AU Ma, L
Piirainen, S
Kulesskaya, N
Rauvala, H
Tian, L
AF Ma, Li
Piirainen, Sami
Kulesskaya, Natalia
Rauvala, Heikki
Tian, Li
TI Association of brain immune genes with social behavior of inbred mouse
strains
SO Journal of Neuroinflammation
LA English
DT Article
DE Social deficit; Inbred mouse strains; Immune genes; Behaviors; Brain
morphology
ID GENOME-WIDE ASSOCIATION; DBA/2 MICE; SCHIZOPHRENIA; ACTIVATION;
MICROGLIA; SYSTEM; AUTISM; EXPRESSION; ANXIETY; CNS
AB Background: Social deficit is one of the core symptoms of neuropsychiatric diseases, in which immune genes play an important role. Although a few immune genes have been shown to regulate social and emotional behaviors, how immune gene network(s) may jointly regulate sociability has not been investigated so far.
Methods: To decipher the potential immune-mediated mechanisms underlying social behavior, we first studied the brain microarray data of eight inbred mouse strains with known variations in social behavior and retrieved the differentially expressed immune genes. We then made a protein-protein interaction analysis of them to find the major networks and explored the potential association of these genes with the behavior and brain morphology in the mouse phenome database. To validate the expression and function of the candidate immune genes, we selected the C57BL/6 J and DBA/2 J strains among the eight inbred strains, compared their social behaviors in resident-intruder and 3-chambered social tests and the mRNA levels of these genes, and analyzed the correlations of these genes with the social behaviors.
Results: A group of immune genes were differentially expressed in the brains of these mouse strains. The representative C57BL/6 J and DBA/2 J strains displayed significant differences in social behaviors, DBA/2 J mice being less active in social dominance and social interaction than C57BL/6 J mice. The mRNA levels of H2-d1 in the prefrontal cortex, hippocampus, and hypothalamus and C1qb in the hippocampus of the DBA/2 J strain were significantly down-regulated as compared to those in the C57BL/6 J strain. In contrast, Polr3b in the hippocampus and Tnfsf13b in the prefrontal cortex of the DBA/2 J strain were up-regulated. Furthermore, C1qb, Cx3cl1, H2-d1, H2-k1, Polr3b, and Tnfsf13b were predicted to be associated with various behavioral and brain morphological features across the eight inbred strains. Importantly, the C1qb mRNA level was confirmed to be significantly correlated with the sociability in DBA/2 J but not in C57BL/6 J mice.
Conclusions: Our study provided evidence on the association of immune gene network(s) with the brain development and behavior in animals and revealed neurobiological functions of novel brain immune genes that may contribute to social deficiency in animal models of neuropsychiatric disorders.
C1 [Ma, Li; Piirainen, Sami; Kulesskaya, Natalia; Rauvala, Heikki; Tian, Li] Univ Helsinki, Ctr Neurosci, FIN-00014 Helsinki, Finland.
[Tian, Li] Beijing Huilongguan Hosp, Psychiat Res Ctr, Beijing 100096, Changping, Peoples R China.
RP Tian, L (reprint author), Univ Helsinki, Ctr Neurosci, Viikinkaari 4, FIN-00014 Helsinki, Finland.
EM li.tian@helsinki.fi
FU Academy of Finland [1273108]; National Natural Science Foundation of
China [81461130016]; European Commission [602919]; Integrative Life
Science graduate program of the University of Helsinki; Ida Montinin
foundation; TEKES, Finland
FX This study is supported by the Academy of Finland Project No. 1273108,
National Natural Science Foundation of China Project No. 81461130016,
and European Commission FP7/Cooperation
sub-programme/HEALTH-2013-Innovation Grant No. 602919 to LT. LM is
supported by the Integrative Life Science graduate program of the
University of Helsinki, Ida Montinin foundation, and Academy of Finland.
SP is supported by the Academy of Finland. NK and HR are supported by
TEKES, Finland.
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Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD APR 18
PY 2015
VL 12
AR 75
DI 10.1186/s12974-015-0297-5
PG 10
WC Immunology; Neurosciences
SC Immunology; Neurosciences & Neurology
GA CG4PQ
UT WOS:000353269000001
PM 25895500
ER
PT J
AU Hwang, SR
Kim, CY
Shin, KM
Jo, JH
Kim, HA
Heo, Y
AF Hwang, So-Ryeon
Kim, Chang-Yul
Shin, Kyung-Min
Jo, Ji-Hoon
Kim, Hyoung-Ah
Heo, Yong
TI Altered Expression Levels of Neurodevelopmental Proteins in Fetal Brains
of BTBR T+tf/J Mice with Autism-Like Behavioral Characteristics
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID SPECTRUM DISORDERS; NEUROTROPHIC FACTOR; OXIDATIVE STRESS; INBRED
STRAINS; MOUSE MODEL; AUTOANTIBODIES; CHILDREN; RELEVANT; SERA
AB Autism is a brain developmental disorder with characteristics of social interaction defects, language and communication dysfunction, and repetitive behavior. Occurrence of autism is continuously increasing, but the cause of autism is not clearly defined. Genetic linkage or environmental factors were proposed as sources for pathogenesis of autism. BTBR T+tf/J (BTBR) mice were reported as an appropriate animal model for autism investigation because of their similarities in behavioral abnormalities with human autistic subjects. The aim of this study was to evaluate expression levels of proteins involved with brain development at fetal stage of BTBR mice. FVB/NJ mice were used as a control strain because of their social behaviors. Level of fetal brain immunoglobulin (Ig) G deposit was also evaluated. Fetal brains were obtained at d 18 of gestational period. Thirty-one and 27 fetuses were obtained from 3 pregnant BTBR and FVB dams, respectively. The level of glial fibrillary acidic protein expression was significantly lower in fetal brains of BTBR than FVB/NJ mice. Expression of brain-derived neurotrophic factor and myelin basic protein was significantly more upregulated in BTBR than in FVB/NJ mice. No significant difference was obtained for nerve growth factor between the two strains. Levels of IgG isotypes deposited in fetal brain of BTBR mice were significantly higher than in FVB mice except for IgG1. Overall, these results suggest that prenatal alterations in expression of various fetal brain proteins may be implicated in aberrant behavioral characteristics of BTBR mice.
C1 [Hwang, So-Ryeon; Kim, Chang-Yul; Shin, Kyung-Min; Jo, Ji-Hoon; Heo, Yong] Catholic Univ Daegu, Coll Med & Publ Hlth Sci, Dept Occupat Hlth, Gyongsan 712702, Gyeongbuk Provi, South Korea.
[Kim, Hyoung-Ah] Catholic Univ Korea, Dept Prevent Med, Coll Med, Seoul, South Korea.
RP Heo, Y (reprint author), Catholic Univ Daegu, Coll Med & Publ Hlth Sci, Dept Occupat Hlth, 13-13 Hayang Ro, Gyongsan 712702, Gyeongbuk Provi, South Korea.
EM yheo@cu.ac.kr
FU National Research Foundation of Korea [2010-0022169]; Catholic
University of Daegu [20121291]
FX This study was supported by the National Research Foundation of Korea
(grant 2010-0022169) and Catholic University of Daegu (grant 20121291).
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NR 41
TC 0
Z9 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1528-7394
EI 1087-2620
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PD APR 18
PY 2015
VL 78
IS 8
BP 516
EP 523
DI 10.1080/15287394.2015.1010466
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA CF5SV
UT WOS:000352618200004
PM 25849768
ER
PT J
AU Zapf, AC
Glindemann, LA
Vogeley, K
Falter, CM
AF Zapf, Alexandra C.
Glindemann, Liv A.
Vogeley, Kai
Falter, Christine M.
TI Sex Differences in Mental Rotation and How They Add to the Understanding
of Autism
SO PLOS ONE
LA English
DT Article
ID MALE BRAIN THEORY; SPATIAL ABILITY; HANDEDNESS; TESTOSTERONE
AB The most consistent cognitive sex differences have been found in the visuo-spatial domain, using Mental Rotation (MR) tasks. Such sex differences have been suggested to bear implications on our understanding of autism spectrum disorders (ASD). However, it is still debated how the sex difference in MR performance relates to differences between individuals with ASD compared to typically developed control persons (TD). To provide a detailed exploration of sex differences in MR performance, we studied rotational (indicated by slopes) and non-rotational aspects (indicated by intercepts) of the MR task in TD individuals (total N = 50). Second-to-fourth digit length ratios (2D:4D) were measured to investigate the associations between prenatal testosterone and performance on MR tasks. Handedness was assessed by the use of the Edinburgh Handedness Inventory in order to examine the relation between handedness and MR performance. In addition, we investigated the relation of spatial to systemising abilities, both of which have been associated with sex differences and with ASD, employing the Intuitive Physics Test (IPT). Results showed a male advantage in rotational aspects of the MR task, which correlated with IPT results. These findings are in contrast to the MR performance of individuals with ASD who have been shown to outperform TD persons in the non-rotational aspects of the MR task. These results suggest that the differences in MR performance due to ASD are different from sex-related differences in TD persons, in other words, ASD is not a simple and continuous extension of the male cognitive profile into the psychopathological range as the extreme male brain hypothesis (EMB) of ASD would suggest.
C1 [Zapf, Alexandra C.; Glindemann, Liv A.] Univ Groningen, Dept Clin & Dev Neuropsychol, NL-9712 TS Groningen, Netherlands.
[Vogeley, Kai; Falter, Christine M.] Univ Hosp Cologne, Dept Psychiat, D-50924 Cologne, Germany.
[Vogeley, Kai] Res Ctr Juelich, Inst Neurosci & Med Cognit Neurosci INM 3, D-52425 Julich, Germany.
RP Falter, CM (reprint author), Univ Hosp Cologne, Dept Psychiat, Kerpener Str 62, D-50924 Cologne, Germany.
EM christine.falter@cantab.net
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NR 23
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 17
PY 2015
VL 10
IS 4
AR e0124628
DI 10.1371/journal.pone.0124628
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CG1EX
UT WOS:000353017000138
PM 25884501
ER
PT J
AU Naguib, A
Bencze, G
Cho, H
Zheng, W
Tocilj, A
Elkayam, E
Faehnle, CR
Jaber, N
Pratt, CP
Chen, MH
Zong, WX
Marks, MS
Joshua-Tor, L
Pappin, DJ
Trotman, LC
AF Naguib, Adam
Bencze, Gyula
Cho, Hyejin
Zheng, Wu
Tocilj, Ante
Elkayam, Elad
Faehnle, Christopher R.
Jaber, Nadia
Pratt, Christopher P.
Chen, Muhan
Zong, Wei-Xing
Marks, Michael S.
Joshua-Tor, Leemor
Pappin, Darryl J.
Trotman, Lloyd C.
TI PTEN Functions by Recruitment to Cytoplasmic Vesicles
SO MOLECULAR CELL
LA English
DT Article
ID TUMOR-SUPPRESSOR GENE; PROSTATE-CANCER PROGRESSION; AUTISM SPECTRUM
DISORDERS; PHOSPHATIDYLINOSITOL 3-PHOSPHATE; LIPID 2ND-MESSENGER;
MEMBRANE DYNAMICS; CRYSTAL-STRUCTURE; IDENTIFICATION; PHOSPHATASE;
AUXILIN
AB PTEN is proposed to function at the plasma membrane, where receptor tyrosine kinases are activated. However, the majority of PTEN is located throughout the cytoplasm. Here, we show that cytoplasmic PTEN is distributed along microtubules, tethered to vesicles via phosphatidylinositol 3-phosphate (PI(3) P), the signature lipid of endosomes. We demonstrate that the non-catalytic C2 domain of PTEN specifically binds PI(3) P through the CBR3 loop. Mutations render this loop incapable of PI(3) P binding and abrogate PTEN-mediated inhibition of PI 3-kinase/AKT signaling. This loss of function is rescued by fusion of the loop mutant PTEN to FYVE, the canonical PI(3) P binding domain, demonstrating the functional importance of targeting PTEN to endosomal membranes. Beyond revealing an upstream activation mechanism of PTEN, our data introduce the concept of PI 3-kinase signal activation on the vast plasma membrane that is contrasted by PTEN-mediated signal termination on the small, discrete surfaces of internalized vesicles.
C1 [Naguib, Adam; Bencze, Gyula; Cho, Hyejin; Zheng, Wu; Tocilj, Ante; Elkayam, Elad; Faehnle, Christopher R.; Pratt, Christopher P.; Chen, Muhan; Joshua-Tor, Leemor; Pappin, Darryl J.; Trotman, Lloyd C.] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA.
[Tocilj, Ante; Elkayam, Elad; Faehnle, Christopher R.; Joshua-Tor, Leemor] WM Keck Struct Biol Lab, Cold Spring Harbor, NY 11724 USA.
[Elkayam, Elad; Joshua-Tor, Leemor] Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA.
[Jaber, Nadia; Zong, Wei-Xing] SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA.
[Marks, Michael S.] Childrens Hosp Philadelphia, Dept Pathol, Philadelphia, PA 19104 USA.
[Marks, Michael S.] Childrens Hosp Philadelphia, Lab Med, Philadelphia, PA 19104 USA.
[Marks, Michael S.] Univ Penn, Dept Pathol, Philadelphia, PA 19104 USA.
[Marks, Michael S.] Univ Penn, Lab Med & Physiol, Philadelphia, PA 19104 USA.
RP Trotman, LC (reprint author), Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA.
EM trotman@cshl.edu
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NR 68
TC 0
Z9 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1097-2765
EI 1097-4164
J9 MOL CELL
JI Mol. Cell
PD APR 16
PY 2015
VL 58
IS 2
BP 255
EP 268
DI 10.1016/j.molcel.2015.03.011
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CG4AR
UT WOS:000353222900008
PM 25866245
ER
PT J
AU Esposito, G
Setoh, P
Yoshida, S
Kuroda, KO
AF Esposito, Gianluca
Setoh, Peipei
Yoshida, Sachine
Kuroda, Kumi O.
TI The calming effect of maternal carrying in different mammalian species
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE maternal carrying; mother-infant interaction; mother-child relations;
mother-infant bonding; transport response; attachment
ID TRANSPORT RESPONSE; RAT PUPS; AUTISM; MOTHER; DIAGNOSIS; CONTACT;
HUMANS; GAIT; MICE
AB Attachment theory postulates that mothers and their infants possess some basic physiological mechanisms that favor their dyadic interaction and bonding. Many studies have focused on the maternal physiological mechanisms that promote attachment (e.g., mothers' automatic responses to infant faces and/or cries), and relatively less have examined infant physiology. Thus, the physiological mechanisms regulating infant bonding behaviors remain largely undefined. This review elucidates some of the neurobiological mechanisms governing social bonding and cooperation in humans by focusing on maternal carrying and its beneficial effect on mother infant interaction in mammalian species (e.g., in humans, big cats, and rodents). These studies show that infants have a specific calming response to maternal carrying. A human infant carried by his/her walking mother exhibits a rapid heart rate decrease, and immediately stops voluntary movement and crying compared to when he/she is held in a sitting position. Furthermore, strikingly similar responses were identified in mouse rodents, who exhibit immobility, diminished ultra-sonic vocalizations and heart rate. In general, the studies described in the current review demonstrate the calming effect of maternal carrying to be comprised of a complex set of behavioral and physiological components, each of which has a specific postnatal time window and is orchestrated in a well-matched manner with the maturation of the infants. Such reactions could have been evolutionarily adaptive in mammalian mother infant interactions. The findings have implications for parenting practices in developmentally normal populations. In addition, we propose that infants' physiological response may be useful in clinical assessments as we discuss possible implications on early screening for child psychopathology (e.g., autism spectrum disorders and perinatal brain disorders).
C1 [Esposito, Gianluca] Univ Trento, Dept Psychol & Cognit Sci, Affiliat Behav & Physiol Lab, I-38068 Rovereto, Italy.
[Esposito, Gianluca; Setoh, Peipei] Nanyang Technol Univ, Div Psychol, Singapore 639798, Singapore.
[Yoshida, Sachine] Toho Univ, Fac Med, Tokyo, Japan.
[Yoshida, Sachine] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol, Saitama, Japan.
[Kuroda, Kumi O.] RIKEN Brain Sci Inst, Unit Affiliat Social Behav Unit, Saitama, Japan.
RP Esposito, G (reprint author), Univ Trento, Dept Psychol & Cognit Sci, Affiliat Behav & Physiol Lab, Corso Bettini 31, I-38068 Rovereto, Italy.
EM gianluca.esposito@unitn.it
FU Japan Society for the Promotion of Science [24730563, 2402747]; FP7
PEOPLE-Marie Curie Career Integration [PCIG14-GA-2013-630166];
Intramural Research Program of the Humanities and Social Sciences
School, Nanyang Technological University
FX This research was supported by the Grant-in-aid for Scientific Research
from Japan Society for the Promotion of Science (Projects #24730563 and
#2402747), FP7 PEOPLE-Marie Curie Career Integration Grants
(PCIG14-GA-2013-630166), and the Intramural Research Program of the
Humanities and Social Sciences School, Nanyang Technological University.
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Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD APR 16
PY 2015
VL 6
AR 445
DI 10.3389/fpsyg.2015.00445
PG 6
WC Psychology, Multidisciplinary
SC Psychology
GA CG0JS
UT WOS:000352953400001
PM 25932017
ER
PT J
AU Codina-Sola, M
Rodriguez-Santiago, B
Homs, A
Santoyo, J
Rigau, M
Aznar-Lain, G
del Campo, M
Gener, B
Gabau, E
Botella, MP
Gutierrez-Arumi, A
Antinolo, G
Perez-Jurado, LA
Cusco, I
AF Codina-Sola, Marta
Rodriguez-Santiago, Benjamin
Homs, Aida
Santoyo, Javier
Rigau, Maria
Aznar-Lain, Gemma
del Campo, Miguel
Gener, Blanca
Gabau, Elisabeth
Pilar Botella, Maria
Gutierrez-Arumi, Armand
Antinolo, Guillermo
Alberto Perez-Jurado, Luis
Cusco, Ivon
TI Integrated analysis of whole-exome sequencing and transcriptome
profiling in males with autism spectrum disorders
SO MOLECULAR AUTISM
LA English
DT Article
DE ASD; Whole-exome sequencing; CNV; SNV
ID DE-NOVO MUTATIONS; GAIN-OF-FUNCTION; INTELLECTUAL DISABILITY;
DIFFERENTIAL EXPRESSION; MENTAL-RETARDATION; MISSENSE MUTATIONS;
IMPRINTED GENES; IDENTIFICATION; GENETICS; VARIANTS
AB Background: Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with high heritability. Recent findings support a highly heterogeneous and complex genetic etiology including rare de novo and inherited mutations or chromosomal rearrangements as well as double or multiple hits.
Methods: We performed whole-exome sequencing (WES) and blood cell transcriptome by RNAseq in a subset of male patients with idiopathic ASD (n = 36) in order to identify causative genes, transcriptomic alterations, and susceptibility variants.
Results: We detected likely monogenic causes in seven cases: five de novo (SCN2A, MED13L, KCNV1, CUL3, and PTEN) and two inherited X-linked variants (MAOA and CDKL5). Transcriptomic analyses allowed the identification of intronic causative mutations missed by the usual filtering of WES and revealed functional consequences of some rare mutations. These included aberrant transcripts (PTEN, POLR3C), deregulated expression in 1.7% of mutated genes (that is, SEMA6B, MECP2, ANK3, CREBBP), allele-specific expression (FUS, MTOR, TAF1C), and non-sense-mediated decay (RIT1, ALG9). The analysis of rare inherited variants showed enrichment in relevant pathways such as the PI3K-Akt signaling and the axon guidance.
Conclusions: Integrative analysis of WES and blood RNAseq data has proven to be an efficient strategy to identify likely monogenic forms of ASD (19% in our cohort), as well as additional rare inherited mutations that can contribute to ASD risk in a multifactorial manner. Blood transcriptomic data, besides validating 88% of expressed variants, allowed the identification of missed intronic mutations and revealed functional correlations of genetic variants, including changes in splicing, expression levels, and allelic expression.
C1 [Codina-Sola, Marta; Homs, Aida; Rigau, Maria; del Campo, Miguel; Gutierrez-Arumi, Armand; Alberto Perez-Jurado, Luis; Cusco, Ivon] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona 08003, Spain.
[Codina-Sola, Marta; Homs, Aida; Gutierrez-Arumi, Armand; Alberto Perez-Jurado, Luis; Cusco, Ivon] Hosp del Mar, Res Inst IMIM, Barcelona 08003, Spain.
[Codina-Sola, Marta; Homs, Aida; del Campo, Miguel; Gutierrez-Arumi, Armand; Antinolo, Guillermo; Alberto Perez-Jurado, Luis; Cusco, Ivon] Ctr Invest Biomed Red Enfermedades Raras CIBER ER, Madrid 28029, Spain.
[Rodriguez-Santiago, Benjamin] Quantitat Genom Med Labs qGenom, Barcelona 08003, Spain.
[Santoyo, Javier; Antinolo, Guillermo] Genom & Bioinformat Platform Andalusia, Med Genome Project, Seville 41092, Spain.
[Aznar-Lain, Gemma] Hosp del Mar, Pediat Neurol, Barcelona 08003, Spain.
[del Campo, Miguel] Hosp Valle De Hebron, Serv Genet, Barcelona 08015, Spain.
[Gener, Blanca] Hosp Univ Cruces, BioCruces Hlth Res Inst, Genet Serv, Baracaldo 48093, Bizkaia, Spain.
[Gabau, Elisabeth] Corp Sanitaria Parc Tauli, Serv Pediat, Sabadell 08208, Spain.
[Pilar Botella, Maria] Hosp Txagorritxu, Pediat Neurol, Vitoria 01009, Spain.
[Antinolo, Guillermo] Univ Seville, CSIC, Univ Hosp Virgen del Rocio, Inst Biomed Seville IBIS,Dept Genet Reprod & Feta, Seville 41013, Spain.
RP Perez-Jurado, LA (reprint author), Univ Pompeu Fabra, Dept Expt & Hlth Sci, C Doctor Aiguader 88,422, Barcelona 08003, Spain.
EM luis.perez@upf.edu; ivon.cusco@upf.edu
FU Spanish Ministry of Health - FEDER [FIS PI1002512, PI1302481,
PI1300823]; Fundacion Alicia Koplowitz; Generalitat de Catalunya
[2014SGR1468]; 'Subprograma de actuaciones Cientificas y Tecnologicas en
Parques Cientificos y Tecnologicos' (ACTEPARQ); 'Programa Nacional de
Proyectos de investigacion Aplicada', I + D + i; FEDER
FX We would like to thank the patients and their families for their
support. This work was funded by grants from the Spanish Ministry of
Health (FIS PI1002512, PI1302481, and PI1300823 cofunded by FEDER),
Fundacion Alicia Koplowitz and Generalitat de Catalunya (2014SGR1468).
The 'Medical Genome Project' is a joint initiative of the Consejeria de
Salud de la Junta de Andalucia and Roche, supported by the 'Programa
Nacional de Proyectos de investigacion Aplicada', I + D + i 2008,
'Subprograma de actuaciones Cientificas y Tecnologicas en Parques
Cientificos y Tecnologicos' (ACTEPARQ 2009) and FEDER. The CIBER de
Enfermedades Raras is an initiative of the ISCIII. CDTI
FEDER-Innterconecta EXP00052887/ITC-20111037.
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NR 93
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD APR 15
PY 2015
VL 6
AR 21
DI 10.1186/s13229-015-0017-0
PG 16
WC Genetics & Heredity; Neurosciences
SC Genetics & Heredity; Neurosciences & Neurology
GA CH9JE
UT WOS:000354351000001
PM 25969726
ER
PT J
AU Geier, DA
King, PG
Hooker, BS
Dorea, JG
Kern, JK
Sykes, LK
Geier, MR
AF Geier, David A.
King, Paul G.
Hooker, Brian S.
Dorea, Jose G.
Kern, Janet K.
Sykes, Lisa K.
Geier, Mark R.
TI Thimerosal: Clinical, epidemiologic and biochemical studies
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Thimerosal; Ethylmercury; Humans; Neurodevelopment
ID HEPATITIS-B VACCINATION; NEURODEVELOPMENTAL DISORDERS; CONTAINING
VACCINES; NEUROPSYCHOLOGICAL OUTCOMES; AUTISTIC DISORDERS; MERCURY
LEVELS; UNITED-STATES; US CHILDREN; CELL-DEATH; EXPOSURE
AB Introduction: Thimerosal (or Thiomersal) is a trade name for an organomercurial compound (sodium ethylmercury (Hg) thiosalicylate) that is 49.55% Hg by weight, which rapidly decomposes in aqueous saline solutions into ethyl-Hg hydroxide and ethyl-Hg chloride. Developed in 1927, it has been and is still being used as a preservative in some cosmetics, topical pharmaceuticals, and biological drug products, including vaccines. Concerns have been voiced about its use because it is toxic to human cells. Although it is banned in several countries, it continues to be added to some vaccines in the United States and many vaccines in the developing world.
Discussion: This critical review focuses on the clinical, epidemiological, and biochemical studies of adverse effects from Thimerosal in developing humans. This review will include research that examines fetal, infant, and childhood death; birth defects; neurodevelopmental testing deficits in children; and neurodevelopmental disorders (attention deficit/hyperactivity disorder, autism spectrum disorder, tic disorder, and specific developmental delays). The review will also look at the research that examined the outcomes of acute accidental ethyl-Hg poisoning in humans. The studies that examine the underlying biochemical insights into the neuronal cellular damage will also be explored.
Conclusion: The culmination of the research that examines the effects of Thimerosal in humans indicates that it is a poison at minute levels with a plethora of deleterious consequences, even at the levels currently administered in vaccines. (C) 2015 The Authors. Published by Elsevier B.V.
C1 [Geier, David A.; Kern, Janet K.; Geier, Mark R.] Inst Chron Illnesses Inc, Silver Spring, MD 20905 USA.
[King, Paul G.; Sykes, Lisa K.] CoMeD Inc, Silver Spring, MD 20905 USA.
[Hooker, Brian S.] Simpson Univ, Dept Biol, Redding, CA 96001 USA.
[Dorea, Jose G.] Univ Brasilia, Hlth Sci, BR-70919970 Brasilia, DF, Brazil.
RP Kern, JK (reprint author), 14 Redgate Ct, Silver Spring, MD 20905 USA.
EM davidallengeier@comcast.net; paulgkingphd@gmail.com;
bhooker@simpsonu.edu; jg.dorea@gmail.com; jkern@dfwair.net;
syklone5@verizon.net; mgeier@comcast.net
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NR 81
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD APR 15
PY 2015
VL 444
BP 212
EP 220
DI 10.1016/j.cca.2015.02.030
PG 9
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA CG1BH
UT WOS:000353007500038
PM 25708367
ER
PT J
AU Pedrotti, S
Giudice, J
Dagnino-Acosta, A
Knoblauch, M
Singh, RK
Hanna, A
Mo, QX
Hicks, J
Hamilton, S
Cooper, TA
AF Pedrotti, Simona
Giudice, Jimena
Dagnino-Acosta, Adan
Knoblauch, Mark
Singh, Ravi K.
Hanna, Amy
Mo, Qianxing
Hicks, John
Hamilton, Susan
Cooper, Thomas A.
TI The RNA-binding protein Rbfox1 regulates splicing required for skeletal
muscle structure and function
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID SARCOPLASMIC-RETICULUM; IN-VIVO; SATELLITE CELLS; GENOME-WIDE;
HITS-CLIP; EXPRESSION; BRAIN; AUTISM; MOUSE; GENE
AB The Rbfox family of RNA-binding proteins is highly conserved with established roles in alternative splicing (AS) regulation. High-throughput studies aimed at understanding transcriptome remodeling have revealed skeletal muscle as displaying one of the largest number of AS events. This finding is consistent with requirements for tissue-specific protein isoforms needed to sustain muscle-specific functions. Rbfox1 is abundant in vertebrate brain, heart and skeletal muscle. Genome-wide genetic approaches have linked the Rbfox1 gene to autism, and a brain-specific knockout mouse revealed a critical role for this splicing regulator in neuronal function. Moreover, a Caenorhabditis elegans Rbfox1 homolog regulates muscle-specific splicing. To determine the role of Rbfox1 in muscle function, we developed a conditional knockout mouse model to specifically delete Rbfox1 in adult tissue. We show that Rbfox1 is required for muscle function but a >70% loss of Rbfox1 in satellite cells does not disrupt muscle regeneration. Deep sequencing identified aberrant splicing of multiple genes including those encoding myofibrillar and cytoskeletal proteins, and proteins that regulate calcium handling. Ultrastructure analysis of Rbfox1(-/-) muscle by electron microscopy revealed abundant tubular aggregates. Immunostaining showed mislocalization of the sarcoplasmic reticulum proteins Serca1 and Ryr1 in a pattern indicative of colocalization with the tubular aggregates. Consistent with mislocalization of Serca1 and Ryr1, calcium handling was drastically altered in Rbfox1(-/-) muscle. Moreover, muscle function was significantly impaired in Rbfox1(-/-) muscle as indicated by decreased force generation. These results demonstrate that Rbfox1 regulates a network of AS events required to maintain multiple aspects of muscle physiology.
C1 [Pedrotti, Simona; Giudice, Jimena; Singh, Ravi K.; Hicks, John; Cooper, Thomas A.] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA.
[Cooper, Thomas A.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.
[Dagnino-Acosta, Adan; Knoblauch, Mark; Hanna, Amy; Hamilton, Susan; Cooper, Thomas A.] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA.
[Mo, Qianxing] Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA.
[Mo, Qianxing] Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
[Hicks, John] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
[Hicks, John] Texas Childrens Hosp, Houston, TX 77030 USA.
RP Cooper, TA (reprint author), Baylor Coll Med, Dept Pathol & Immunol, 1 Baylor Plaza,Room 268B, Houston, TX 77030 USA.
EM tcooper@bcm.edu
FU NIH [R01HL045565, R01AR060733, R01AR045653, T32 HL007676]; Muscular
Dystrophy Association; BCM: Genomic and RNA Profiling Core; Integrated
Microscopy Core [HD007495, DK56338, CA125123]; Baculovirus/Monoclonal
Antibody Facility [P30 CA125123]; [R01AR053349]; [R01AR041802]
FX This project is funded by the NIH R01HL045565, R01AR060733 and
R01AR045653 (T.A.C.) and the Muscular Dystrophy Association (T.A.C.);
R01AR053349, R01AR041802 and NIH T32 HL007676 to S.H. This project was
supported by three cores at BCM: Genomic and RNA Profiling Core (Lisa D.
White), Integrated Microscopy Core (HD007495, DK56338 and CA125123)
(Michael Mancini), and Baculovirus/Monoclonal Antibody Facility (P30
CA125123).
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NR 57
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD APR 15
PY 2015
VL 24
IS 8
BP 2360
EP 2374
DI 10.1093/hmg/ddv003
PG 15
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CG1WM
UT WOS:000353066200021
PM 25575511
ER
PT J
AU Shimamoto, C
Ohnishi, T
Maekawa, M
Watanabe, A
Ohba, H
Arai, R
Iwayama, Y
Hisano, Y
Toyota, T
Toyoshima, M
Suzuki, K
Shirayama, Y
Nakamura, K
Mori, N
Owada, Y
Kobayashi, T
Yoshikawa, T
AF Shimamoto, Chie
Ohnishi, Tetsuo
Maekawa, Motoko
Watanabe, Akiko
Ohba, Hisako
Arai, Ryoichi
Iwayama, Yoshimi
Hisano, Yasuko
Toyota, Tomoko
Toyoshima, Manabu
Suzuki, Katsuaki
Shirayama, Yukihiko
Nakamura, Kazuhiko
Mori, Norio
Owada, Yuji
Kobayashi, Tetsuyuki
Yoshikawa, Takeo
TI Functional characterization of FABP3, 5 and 7 gene variants identified
in schizophrenia and autism spectrum disorder and mouse behavioral
studies (vol 23, pg 6495, 2014)
SO HUMAN MOLECULAR GENETICS
LA English
DT Correction
CR Shimamoto Chie, 2014, Hum Mol Genet, V23, P6495, DOI 10.1093/hmg/ddu369
NR 1
TC 0
Z9 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD APR 15
PY 2015
VL 24
IS 8
BP 2409
EP 2409
DI 10.1093/hmg/ddv011
PG 1
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CG1WM
UT WOS:000353066200025
PM 25655139
ER
PT J
AU Gilani, SZ
Tan, DW
Russell-Smith, SN
Maybery, MT
Mian, A
Eastwood, PR
Shafait, F
Goonewardene, M
Whitehouse, AJO
AF Gilani, Syed Zulqarnain
Tan, Diana Weiting
Russell-Smith, Suzanna N.
Maybery, Murray T.
Mian, Ajmal
Eastwood, Peter R.
Shafait, Faisal
Goonewardene, Mithran
Whitehouse, Andrew J. O.
TI Sexually dimorphic facial features vary according to level of
autistic-like traits in the general population
SO JOURNAL OF NEURODEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism; Autism spectrum disorder; Hypermasculinisation; Gender defiant
disorder; Facial features; Masculinity; Femininity; Raine study
ID MALE BRAIN THEORY; PERVASIVE DEVELOPMENTAL DISORDERS; FETAL
TESTOSTERONE; SPECTRUM QUOTIENT; DIGIT RATIO; MORPHOLOGY; ADULTS; FACE;
ADOLESCENCE; DIFFERENCE
AB Background: In a recent study, Bejerot et al. observed that several physical features (including faces) of individuals with an autism spectrum disorder (ASD) were more androgynous than those of their typically developed counterparts, suggesting that ASD may be understood as a 'gender defiant' disorder. These findings are difficult to reconcile with the hypermasculinisation account, which proposes that ASD may be an exaggerated form of cognitive and biological masculinity. The current study extended these data by first identifying six facial features that best distinguished males and females from the general population and then examining these features in typically developing groups selected for high and low levels of autistic-like traits.
Methods: In study 1, three-dimensional (3D) facial images were collected from 208 young adult males and females recruited from the general population. Twenty-three facial distances were measured from these images and a gender classification and scoring algorithm was employed to identify a set of six facial features that most effectively distinguished male from female faces. In study 2, measurements of these six features were compared for groups of young adults selected for high (n = 46) or low (n = 66) levels of autistic-like traits.
Results: For each sex, four of the six sexually dimorphic facial distances significantly differentiated participants with high levels of autistic-like traits from those with low trait levels. All four features were less masculinised for high-trait males compared to low-trait males. Three of four features were less feminised for high-trait females compared to low-trait females. One feature was, however, not consistent with the general pattern of findings and was more feminised among females who reported more autistic-like traits. Based on the four significantly different facial distances for each sex, discriminant function analysis correctly classified 89.7% of the males and 88.9% of the females into their respective high-and low-trait groups.
Conclusions: The current data provide support for Bejerot et al.'s androgyny account since males and females with high levels of autistic-like traits generally showed less sex-typical facial features than individuals with low levels of autistic-like traits.
C1 [Gilani, Syed Zulqarnain; Mian, Ajmal; Shafait, Faisal] Univ Western Australia, Sch Comp Sci & Software Engn, Perth, WA 6009, Australia.
[Tan, Diana Weiting; Russell-Smith, Suzanna N.; Maybery, Murray T.; Whitehouse, Andrew J. O.] Univ Western Australia, Sch Psychol, Neurocognit Dev Unit, Perth, WA 6009, Australia.
[Eastwood, Peter R.] Univ Western Australia, Sch Anat Physiol & Human Biol, Perth, WA 6009, Australia.
[Goonewardene, Mithran] Univ Western Australia, Oral Hlth Ctr Western Australia, Sch Dent, Perth, WA 6009, Australia.
[Tan, Diana Weiting; Whitehouse, Andrew J. O.] Univ Western Australia, Telethon Kids Inst, Perth, WA 6008, Australia.
RP Tan, DW (reprint author), Univ Western Australia, Sch Psychol, Neurocognit Dev Unit, 35 Stirling Highway, Perth, WA 6009, Australia.
EM diana.tan@research.uwa.edu.au
FU University of Western Australia (UWA); Curtin University; UWA Faculty of
Medicine, Dentistry and Health Sciences; Raine Medical Research
Foundation; Telethon Kids Institute; Women's and Infants Research
Foundation; National Health and Medical Research Council (NHMRC)
[1021105, 1021858, 1044840]; NHMRC [APP1003424, 1004065, 513704]; UWA
Faculty of Engineering, Computing and Mathematics; International
Postgraduate Research Scholarships in Australia; Australian Research
Council (ARC) [DP120104713, DP110102399, LP 110201008]
FX Core Management of the Raine Study is funded by the University of
Western Australia (UWA), Curtin University, the UWA Faculty of Medicine,
Dentistry and Health Sciences, the Raine Medical Research Foundation,
the Telethon Kids Institute, and the Women's and Infants Research
Foundation. The authors acknowledge National Health and Medical Research
Council (NHMRC) project grants (#1021105, #1021858, #1044840) towards
funding this data collection. The writing of this article was also
supported by an NHMRC project grant (#APP1003424) and the UWA Faculty of
Engineering, Computing and Mathematics. SZG and DWT are supported by
International Postgraduate Research Scholarships in Australia. SRS is
partly supported by an Australian Research Council (ARC) Discovery grant
(DP120104713). AM (DP110102399) and FS (LP 110201008) are supported by
ARC. AJOW is funded by a Career Development Fellowship from the NHMRC
(#1004065). PRE is supported by a NHMRC Senior Research Fellowship
(#513704). The authors are extremely grateful to the UWA participants,
Raine Study participants and to the Raine Study team for cohort
management and data collection.
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NR 69
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1866-1947
EI 1866-1955
J9 J NEURODEV DISORD
JI J. Neurodev. Disord.
PD APR 15
PY 2015
VL 7
AR 14
DI 10.1186/s11689-015-9109-6
PG 10
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CG3OX
UT WOS:000353190600001
PM 25901187
ER
PT J
AU Skogan, AH
Zeiner, P
Egeland, J
Urnes, AG
Reichborn-Kjennerud, T
Aase, H
AF Skogan, Annette Holth
Zeiner, Pal
Egeland, Jens
Urnes, Anne-Grethe
Reichborn-Kjennerud, Ted
Aase, Heidi
TI Parent ratings of executive function in young preschool children with
symptoms of attention-deficit/-hyperactivity disorder
SO BEHAVIORAL AND BRAIN FUNCTIONS
LA English
DT Article
DE ADHD; Executive function; Preschool; BRIEF-P; Inhibition; Working memory
ID AUTISM SPECTRUM DISORDERS; DEFICIT/HYPERACTIVITY DISORDER;
INDIVIDUAL-DIFFERENCES; EMOTION REGULATION; ADHD; PERFORMANCE; ANXIETY;
VALIDITY; INVENTORY; ADOLESCENTS
AB Background: Recent research has demonstrated that deficits in basic, self-regulatory processes, or executive function (EF), may be related to symptoms of attention-deficit/hyperactivity disorder (ADHD) already during the preschool period. As the majority of studies investigating these relations in young children have been based primarily on clinically administered tests, it is not clear how early symptoms of ADHD may be related to observations of EF in an everyday context. The preschool version of the Behavior Rating Inventory of Executive Function (BRIEF-P) was developed to provide information about EF through observable, behavioral manifestations of self-regulation, and is the most commonly used rating scale for EF assessment in children.
Methods: Relations between symptoms of ADHD reported in the Preschool Age Psychiatric Assessment interview (PAPA), and EF as measured by the BRIEF-P (parent form), were investigated in a large, nonreferred sample of preschool children (37-47 months, n = 1134) recruited from the Norwegian Mother and Child Cohort Study (MoBa) at the Norwegian Institute of Public Health. The inventory's discriminative ability was examined in a subsample consisting of children who met the diagnostic criteria for either ADHD, oppositional defiant disorder (ODD) or anxiety disorder, and typically developing controls (n = 308). The four groups were also compared with regard to patterns of EF difficulties reported in the BRIEF-P.
Results: Of the five BRIEF-P subscales, Inhibit and Working Memory were the two most closely related to ADHD symptoms, together explaining 38.5% of the variance in PAPA symptom ratings. Based on their scores on the Inhibit and Working Memory subscales (combined), 86.4% of the children in the ADHD and TD groups were correctly classified. ADHD symptoms were associated with more severe difficulties across EF domains, and a different EF profile in comparison to children with other symptoms (anxiety, ODD) and to typically developing controls.
Conclusions: Early symptoms of ADHD were linked to parent-reported difficulties primarily within inhibition and working memory, suggesting that deficiencies within these two EF domains characterize early forms of ADHD. Our findings support the clinical utility of the BRIEF-P as a measure of EF in young preschool children with symptoms of ADHD.
C1 [Skogan, Annette Holth; Zeiner, Pal] Oslo Univ Hosp, Div Mental Hlth & Addict, N-0424 Oslo, Norway.
[Egeland, Jens] Univ Oslo, Inst Psychol, N-0317 Oslo, Norway.
[Egeland, Jens] Vestfold Hosp Trust, Tonsberg, Norway.
[Urnes, Anne-Grethe] Eastern & Southern Norway RBUP, Reg Ctr Child & Adolescent Mental Hlth, N-0405 Oslo, Norway.
[Reichborn-Kjennerud, Ted; Aase, Heidi] Norwegian Inst Publ Hlth, Div Mental Hlth, N-0403 Oslo, Norway.
[Reichborn-Kjennerud, Ted] Univ Oslo, Inst Clin Med, N-0317 Oslo, Norway.
RP Skogan, AH (reprint author), Oslo Univ Hosp, Div Mental Hlth & Addict, Pb 4959,Nydalen 0424, N-0424 Oslo, Norway.
EM annette.holth.skogan@ous-hf.no
FU Norwegian South Eastern Health Region [2010081]; Norwegian Ministry of
Health; Norwegian Health Directorate; South-Eastern Health Region; G&PJ
Sorensen Fund for Scientific Research; Norwegian Resource Centre for
ADHD; Ministry of Education and Research; NIH/NINDS [1 UO1 NS 047537-01,
2 UO1 NS 047537-06A1, NO1-ES-75558]; Norwegian Research Council/FUGE
[151918/S10]
FX The present study was supported by a grant from the Norwegian South
Eastern Health Region, grant no. 2010081. The ADHD study, from which the
present data were drawn, was supported by funds and grants from the
Norwegian Ministry of Health, the Norwegian Health Directorate, the
South-Eastern Health Region, G&PJ Sorensen Fund for Scientific Research,
and from the Norwegian Resource Centre for ADHD, Tourette syndrome and
Narcolepsy. MoBa is supported by the Norwegian Ministry of Health, the
Ministry of Education and Research, NIH/NINDS (grant no. 1 UO1 NS
047537-01 and grant no. 2 UO1 NS 047537-06A1, contract no NO1-ES-75558),
and the Norwegian Research Council/FUGE (grant no. 151918/S10). We are
grateful to the children and their parents for their efforts in taking
part in the study, and to the staff of the ADHD study. The authors also
wish to thank Peter Isquith PhD for his valuable input during the
preparation of this paper.
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NR 69
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1744-9081
J9 BEHAV BRAIN FUNCT
JI Behav. Brain Funct.
PD APR 15
PY 2015
VL 11
AR 16
DI 10.1186/s12993-015-0060-1
PG 11
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CG1HE
UT WOS:000353022900001
PM 25889243
ER
PT J
AU Yan, CL
Zhang, J
Hou, Y
AF Yan, Chun-Lin
Zhang, Ji
Hou, Yong
TI Decreased plasma levels of lipoxin A4 in children with autism spectrum
disorders
SO NEUROREPORT
LA English
DT Article
DE autism spectrum disorders; Chinese; lipoxin A4
ID NEUROTROPHIC FACTOR; CHINESE CHILDREN; LIPID MEDIATORS; INFLAMMATION;
A(4); RESOLUTION; PHASE; ACID
AB The aim of this study was to evaluate the plasma levels of lipoxin A4 (LXA4), a mediator involved in the resolution of inflammation in Chinese children with autism spectrum disorders (ASD). From January 2013 to June 2014, a total of 150 children (75 confirmed ASD cases and 75 their age-matched and sex-matched control cases) participated in this study after consent was obtained from their parents. Clinical information was collected. Plasma levels of LXA4 were measured at baseline. The severity of ASD was assessed at admission using the Childhood Autism Rating Scale total score. The results indicated that the mean plasma levels of LXA4 were significantly lower in autistic children compared with the normal children (P< 0.0001). There was a significant negative relationship between circulating LXA4 levels and severity of autism evaluated by Childhood Autism Rating Scale scores (P= 0.006) after adjustment for the possible covariates. On the basis of the receiver operating characteristic curve, the optimal cutoff value of plasma LXA4 levels as an indicator for an auxiliary diagnosis of ASD was projected to be 81.5 pg/ml, which yielded a sensitivity of 90.7% and a specificity of 76.0%, with the area under the curve at 0.911 (95% confidence interval, 0.867-0.955). These results suggested that autistic children had lower plasma LXA4 levels, suggesting an increased susceptibility to recurring inflammation in these samples. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Yan, Chun-Lin] Hebei North Univ, Basic Med Coll, Zhangjiakou, Hebei Province, Peoples R China.
[Zhang, Ji; Hou, Yong] Hebei North Univ, Dept Pharmacol, Zhangjiakou, Hebei Province, Peoples R China.
RP Yan, CL (reprint author), 10 Zuanshi South Rd, Zhangjiakou 075000, Hebei Province, Peoples R China.
EM yanll1842@163.com
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NR 25
TC 0
Z9 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0959-4965
EI 1473-558X
J9 NEUROREPORT
JI Neuroreport
PD APR 15
PY 2015
VL 26
IS 6
BP 341
EP 345
DI 10.1097/WNR.0000000000000350
PG 5
WC Neurosciences
SC Neurosciences & Neurology
GA CE8FO
UT WOS:000352077300007
PM 25714424
ER
PT J
AU Bellinger, SA
Lucas, D
Kleven, GA
AF Bellinger, S. A.
Lucas, D.
Kleven, G. A.
TI An ecologically relevant guinea pig model of fetal behavior
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Prenatal behavior; Fetal movement; Interlimb coordination; Restraint
stress; Cortisol
ID CAVIA-PORCELLUS; PRENATAL STRESS; ANIMAL-MODELS; INFANT RATS; FETUS;
EMERGENCE; MOVEMENTS; RESPONSES; CORTISOL; SLEEP
AB The laboratory guinea pig, Cavia porcellus, shares with humans many similarities during pregnancy and prenatal development, including precocial offspring and social dependence. These similarities suggest the guinea pig as a promising model of fetal behavioral development as well. Using innovative methods of behavioral acclimation, fetal offspring of female IAF hairless guinea pigs time mated to NIH multicolored Hartley males were observed longitudinally without restraint using noninvasive ultrasound at weekly intervals across the 10 week gestation. To ensure that the ultrasound procedure did not cause significant stress, salivary cortisol was collected both before and after each observation. Measures of fetal spontaneous movement and behavioral state were quantified from video recordings from week 3 through the last week before birth. Results from prenatal quantification of Interlimb Movement Synchrony and state organization reveal guinea pig fetal development to be strikingly similar to that previously reported for other rodents and preterm human infants. Salivary cortisol readings taken before and after sonography did not differ at any observation time point. These results suggest this model holds translational promise for studying the prenatal mechanisms of neurobehavioral development, including those that may result from adverse events. Because the guinea pig is a highly social mammal with a wide range of socially oriented vocalizations, this model may also have utility for studying the prenatal origins and trajectories of developmental disabilities with social-emotional components, such as autism. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Bellinger, S. A.; Lucas, D.; Kleven, G. A.] Wright State Univ, Dept Psychol, Dayton, OH 45435 USA.
[Bellinger, S. A.; Lucas, D.] Wright State Univ, Boonshoft Sch Med, Dayton, OH 45435 USA.
RP Kleven, GA (reprint author), Wright State Univ, Dept Psychol, 3640 Colonel Glenn Hwy, Dayton, OH 45435 USA.
EM gale.kleven@wright.edu
FU [NR010798]; [GM086257]
FX The authors thank Ryan Rakoczy, Chris Fitch, Jessica Lane, Neena Zwier,
and Angela Compton, for help with animal handling. Special thanks to
Emily Dudley, D.V.M. for her veterinary expertise, and to the Wright
State University Laboratory of Animal Resource technicians for the care
of our guinea pigs. S. A. Bellinger is now affiliated with the
Department of Psychology at Florida Atlantic University, Boca Raton, FL.
This research was supported by grants NR010798 to GAK and GM086257 to
SAB and DL. The content of this work is solely the responsibility of the
authors and does not necessarily represent the official views of the
National Institute of Nursing Research, the National Heart Lung and
Blood Institute, or the National Institutes of Health. Portions of this
work were previously presented at the annual meeting of the
International Society for Developmental Psychobiology (New Orleans, LA,
2012), and in 2013 at the annual meeting of the Society for Neuroscience
(San Diego, CA).
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NR 64
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD APR 15
PY 2015
VL 283
BP 175
EP 183
DI 10.1016/j.bbr.2015.01.047
PG 9
WC Behavioral Sciences; Neurosciences
SC Behavioral Sciences; Neurosciences & Neurology
GA CE6UF
UT WOS:000351973000022
PM 25655512
ER
PT J
AU Olivier, JDA
Akerud, H
Poromaa, IS
AF Olivier, Jocelien D. A.
Akerud, Helena
Poromaa, Inger Sundstrom
TI Antenatal depression and antidepressants during pregnancy: Unraveling
the complex interactions for the offspring
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Antenatal depressro; Antidepressants; SSRI; Pregnancy; Neurodevelopment;
Epigenetics
ID SEROTONIN REUPTAKE INHIBITORS; EXPOSED IN-UTERO; 11-BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE-1; CORTICOTROPIN-RELEASING HORMONE;
CORTICOSTEROID-BINDING GLOBULIN; MATERNAL PSYCHOLOGICAL DISTRESS;
NATIONAL-COMORBIDITY-SURVEY; AUTISM SPECTRUM DISORDERS; PROMOTER
GENOTYPE SLC6A4; INFANT TEMPERAMENT
AB During pregnancy the risk for a woman to develop a depressive episode is as high as 20%. Antenatal depression is not harmless for the developing child as several changes, including neurodevelopmental alterations, have been reported. Sometimes it is unavoidable to treat a pregnant mother with antidepressants, especially when she is suicidal. Currently, selective serotonin reuptake inhibitors (SSRls) are the pharmacological choice of antidepressant treatment. SSRIs do not cause gross teratogenic alterations and are generally considered safe for use in pregnancy. However, although SSRls may relieve the maternal symptoms, they definitively cross the placenta partially influencing the neurodevelopment of the fetus. In this review an overview is given of the effects on the offspring of maternal antenatal depression and the putative neurodevelopmental effects of SSRI treatment during pregnancy. Although we primarily focus on human data, some animal data are discussed to describe possible mechanisms on how SSRls are affecting underlying biological mechanisms associated with depression. In summary, maternal depression may have long-lasting effects on the offspring, whereas prenatal SSRI exposure also increases the risk for long-lasting effects. It remains to be determined whether the effects found after SSRI treatment in pregnant women are only due to the SSRI exposure or if the underlying depression is also contributing to these effects. The possibility of epigenetic alterations as one of the underlying mechanisms that is altered by SSRI exposure is discussed. However much more research in this area is needed to explain the exact role of epigenetic mechanisms in SSRI exposure during pregnancy. (C) 2014 Elsevier BA/. All rights reserved,
C1 [Olivier, Jocelien D. A.; Akerud, Helena; Poromaa, Inger Sundstrom] Uppsala Univ, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden.
[Olivier, Jocelien D. A.] Karolinska Inst, Ctr Gender Med, Stockholm, Sweden.
[Olivier, Jocelien D. A.] Univ Groningen, Dept Behav Physiol, Ctr Behav & Neurosci, Groningen, Netherlands.
RP Olivier, JDA (reprint author), Uppsala Univ, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden.
EM jocelien.olivier@kbh.uu.se
FU Swedish Research Council [K2014-54X-20642-07-4]; Marianne and Marcus
Wallenberg Foundation [2010:0031]; KI fonder research [2013fobi37758];
Soderstrom-Konigska [SLS-303881]; Svenska Lakaresallskapet [SLS-384001]
FX This work was supported by grants from the Swedish Research Council,
(Grant No. K2014-54X-20642-07-4) the Marianne and Marcus Wallenberg
Foundation (2010:0031), KI fonder research (2013fobi37758),
Soderstrom-Konigska (SLS-303881) and Svenska Lakaresallskapet
(SLS-384001).
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NR 94
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD APR 15
PY 2015
VL 753
BP 257
EP 262
DI 10.1016/j.ejphar.2014.07.049
PG 6
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA CE6ND
UT WOS:000351953200024
PM 25094036
ER
PT J
AU Micucci, JA
Sperry, ED
Martin, DM
AF Micucci, Joseph A.
Sperry, Ethan D.
Martin, Donna M.
TI Chromodomain Helicase DNA-Binding Proteins in Stem Cells and Human
Developmental Diseases
SO STEM CELLS AND DEVELOPMENT
LA English
DT Review
ID DE-NOVO MUTATIONS; AUTISM SPECTRUM DISORDERS; HUMAN CHARGE SYNDROME;
EPILEPTIC ENCEPHALOPATHIES; INTELLECTUAL DISABILITY;
CHROMATIN-STRUCTURE; TUMOR-SUPPRESSOR; PROSTATE-CANCER; GENE-EXPRESSION;
DAMAGE RESPONSE
AB Dynamic regulation of gene expression is vital for proper cellular development and maintenance of differentiated states. Over the past 20 years, chromatin remodeling and epigenetic modifications of histones have emerged as key controllers of rapid reversible changes in gene expression. Mutations in genes encoding enzymes that modify chromatin have also been identified in a variety of human neurodevelopmental disorders, ranging from isolated intellectual disability and autism spectrum disorder to multiple congenital anomaly conditions that affect major organ systems and cause severe morbidity and mortality. In this study, we review recent evidence that chromodomain helicase DNA-binding (CHD) proteins regulate stem cell proliferation, fate, and differentiation in a wide variety of tissues and organs. We also highlight known roles of CHD proteins in human developmental diseases and present current unanswered questions about the pleiotropic effects of CHD protein complexes, their genetic targets, nucleosome sliding functions, and enzymatic effects in cells and tissues.
C1 [Micucci, Joseph A.] Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA.
[Sperry, Ethan D.; Martin, Donna M.] Univ Michigan, Sch Med, Med Scientist Training Program, Ann Arbor, MI USA.
[Sperry, Ethan D.; Martin, Donna M.] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI USA.
[Martin, Donna M.] Univ Michigan, Sch Med, Dept Pediat & Communicable Dis, Ann Arbor, MI USA.
RP Martin, DM (reprint author), 3520A MSRBI,1150 West Med Ctr Dr,SPC 5652, Ann Arbor, MI 48109 USA.
EM donnamm@umich.edu
FU NIH Hearing, Balance, and Chemical Senses Training Grant [T32-DC000011];
NRSA [F31-DC013227]; University of Michigan Medical Scientist Training
Program [NIH T32-GM007863]; NIH [R01-DC009410]; University of Michigan
Donita B. Sullivan, MD Research Professorship Funds; [T32-HL007439]
FX J.A.M. was supported by the NIH Hearing, Balance, and Chemical Senses
Training Grant (T32-DC000011) and an Individual NRSA (F31-DC013227) and
is currently supported by T32-HL007439. E.D.S. is a fellow of the
University of Michigan Medical Scientist Training Program (NIH
T32-GM007863) and is supported by T32-DC000011. D.M.M. is supported by
NIH R01-DC009410 and the University of Michigan Donita B. Sullivan, MD
Research Professorship Funds.
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NR 101
TC 0
Z9 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1547-3287
EI 1557-8534
J9 STEM CELLS DEV
JI Stem Cells Dev.
PD APR 15
PY 2015
VL 24
IS 8
BP 917
EP 926
DI 10.1089/scd.2014.0544
PG 10
WC Cell & Tissue Engineering; Hematology; Medicine, Research &
Experimental; Transplantation
SC Cell Biology; Hematology; Research & Experimental Medicine;
Transplantation
GA CF1QH
UT WOS:000352322200001
PM 25567374
ER
PT J
AU Wang, R
Chen, CC
Hara, E
Rivas, MV
Roulhac, PL
Howard, JT
Chakraborty, M
Audet, JN
Jarvis, ED
AF Wang, Rui
Chen, Chun-Chun
Hara, Erina
Rivas, Miriam V.
Roulhac, Petra L.
Howard, Jason T.
Chakraborty, Mukta
Audet, Jean-Nicolas
Jarvis, Erich D.
TI Convergent Differential Regulation of SLIT-ROBO Axon Guidance Genes in
the Brains of Vocal Learners
SO JOURNAL OF COMPARATIVE NEUROLOGY
LA English
DT Article
DE songbird; parrot; hummingbird; neural connectivity; axon guidance; vocal
learning
ID MELOPSITTACUS-UNDULATUS; CONTROL PATHWAYS; NEURAL PATHWAYS; ZEBRA
FINCHES; BIRDS; ORGANIZATION; LANGUAGE; COMMUNICATION; BUDGERIGARS;
FOREBRAIN
AB Only a few distantly related mammals and birds have the trait of complex vocal learning, which is the ability to imitate novel sounds. This ability is critical for speech acquisition and production in humans, and is attributed to specialized forebrain vocal control circuits that have several unique connections relative to adjacent brain circuits. As a result, it has been hypothesized that there could exist convergent changes in genes involved in neural connectivity of vocal learning circuits. In support of this hypothesis, expanding on our related study (Pfenning et al. [2014] Science 346: 1256846), here we show that the forebrain part of this circuit that makes a relatively rare direct connection to brainstem vocal motor neurons in independent lineages of vocal learning birds (songbird, parrot, and hummingbird) has specialized regulation of axon guidance genes from the SLIT-ROBO molecular pathway. The SLIT1 ligand was differentially downregulated in the motor song output nucleus that makes the direct projection, whereas its receptor ROBO1 was developmentally upregulated during critical periods for vocal learning. Vocal nonlearning bird species and male mice, which have much more limited vocal plasticity and associated circuits, did not show comparable specialized regulation of SLIT-ROBO genes in their nonvocal motor cortical regions. These findings are consistent with SLIT and ROBO gene dysfunctions associated with autism, dyslexia, and speech sound language disorders and suggest that convergent evolution of vocal learning was associated with convergent changes in the SLIT-ROBO axon guidance pathway. J. Comp. Neurol. 523:892-906, 2015. (c) 2014 Wiley Periodicals, Inc.
C1 [Wang, Rui; Chen, Chun-Chun; Hara, Erina; Rivas, Miriam V.; Roulhac, Petra L.; Howard, Jason T.; Chakraborty, Mukta; Jarvis, Erich D.] Duke Univ, Med Ctr, Dept Neurobiol, Howard Hughes Med Inst, Durham, NC 27710 USA.
[Wang, Rui] Duke Univ, Inst Genome Sci & Policy, Computat Biol & Bioinformat Program, Durham, NC 27710 USA.
[Wang, Rui] Beijing Prosperous Biopharm, Beijing 100085, Peoples R China.
[Rivas, Miriam V.] Vet Affairs Med Ctr, Res Serv, Durham, NC 27710 USA.
[Audet, Jean-Nicolas] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada.
RP Jarvis, ED (reprint author), Duke Univ, Med Ctr, Dept Neurobiol, Howard Hughes Med Inst, Durham, NC 27710 USA.
EM jarvis@neuro.duke.edu
RI Audet, Jean-Nicolas/P-2535-2014; Jarvis, Erich/A-2319-2008
OI Audet, Jean-Nicolas/0000-0002-0511-183X; Jarvis,
Erich/0000-0001-8931-5049
FU National Institutes of Health; Howard Hughes Medical Institute
FX Grant sponsor: National Institutes of Health (Director's Pioneer Award);
Grant sponsor: the Howard Hughes Medical Institute (to E.D.J.).
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NR 52
TC 1
Z9 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9967
EI 1096-9861
J9 J COMP NEUROL
JI J. Comp. Neurol.
PD APR 15
PY 2015
VL 523
IS 6
BP 892
EP 906
DI 10.1002/cne.23719
PG 15
WC Neurosciences; Zoology
SC Neurosciences & Neurology; Zoology
GA CC0CG
UT WOS:000350002000003
PM 25424606
ER
PT J
AU Spunt, RP
Elison, JT
Dufour, N
Hurlemann, R
Saxe, R
Adolphs, R
AF Spunt, Robert P.
Elison, Jed T.
Dufour, Nicholas
Hurlemann, Rene
Saxe, Rebecca
Adolphs, Ralph
TI Amygdala lesions do not compromise the cortical network for false-belief
reasoning
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE theory-of-mind; amygdala; lesions; false-belief; fMRI
ID MONKEYS MACACA-MULATTA; SOCIAL COGNITION; TEMPOROPARIETAL JUNCTION;
INDIVIDUAL-DIFFERENCES; FUNCTIONAL AMYGDALA; PREFRONTAL CORTEX;
FRONTAL-CORTEX; MIND; DAMAGE; AUTISM
AB The amygdala plays an integral role in human social cognition and behavior, with clear links to emotion recognition, trust judgments, anthropomorphization, and psychiatric disorders ranging from social phobia to autism. A central feature of human social cognition is a theory-of-mind (ToM) that enables the representation other people's mental states as distinct from one's own. Numerous neuroimaging studies of the best studied use of ToM-false-belief reasoning-suggest that it relies on a specific cortical network; moreover, the amygdala is structurally and functionally connected with many components of this cortical network. It remains unknown whether the cortical implementation of any form of ToM depends on amygdala function. Here we investigated this question directly by conducting functional MRI on two patients with rare bilateral amygdala lesions while they performed a neuroimaging protocol standardized for measuring cortical activity associated with false-belief reasoning. We compared patient responses with those of two healthy comparison groups that included 480 adults. Based on both univariate and multivariate comparisons, neither patient showed any evidence of atypical cortical activity or any evidence of atypical behavioral performance; moreover, this pattern of typical cortical and behavioral response was replicated for both patients in a follow-up session. These findings argue that the amygdala is not necessary for the cortical implementation of ToM in adulthood and suggest a reevaluation of the role of the amygdala and its cortical interactions in human social cognition.
C1 [Spunt, Robert P.; Elison, Jed T.; Adolphs, Ralph] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
[Elison, Jed T.] Univ Minnesota, Inst Child Dev, Minneapolis, MN 55455 USA.
[Dufour, Nicholas; Saxe, Rebecca] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
[Hurlemann, Rene] Univ Bonn, Dept Psychiat, D-53113 Bonn, Germany.
RP Spunt, RP (reprint author), CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
EM spunt@caltech.edu
FU Della Martin Foundation; National Institute of Mental Health; Packard
Foundation; Simons Foundation
FX We thank Mike Tyszka, the California Institute of Technology Brain
Imaging Center, and the Martinos Imaging Center at MIT for help with the
neuroimaging. Funding support was supplied by the Della Martin
Foundation, the National Institute of Mental Health, the Packard
Foundation, and the Simons Foundation.
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NR 56
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Z9 0
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 14
PY 2015
VL 112
IS 15
BP 4827
EP 4832
DI 10.1073/pnas.1422679112
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CF9BO
UT WOS:000352856800078
PM 25825732
ER
PT J
AU Xiang, AH
Wang, XH
Martinez, MP
Walthall, JC
Curry, ES
Page, K
Buchanan, TA
Coleman, KJ
Getahun, D
AF Xiang, Anny H.
Wang, Xinhui
Martinez, Maya P.
Walthall, Johanna C.
Curry, Edward S.
Page, Kathleen
Buchanan, Thomas A.
Coleman, Karen J.
Getahun, Darios
TI Association of Maternal Diabetes With Autism in Offspring
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID SPECTRUM DISORDERS; ETHNIC DISPARITIES; GLUCOSE-TOLERANCE; CHILDHOOD
AUTISM; OXIDATIVE STRESS; RISK-FACTORS; MELLITUS; PREGNANCY; OBESITY;
METAANALYSIS
AB IMPORTANCE Information about the association of maternal diabetes and autism spectrum disorders (ASDs) in offspring is limited, with no report on the importance of timing of exposure during gestation.
OBJECTIVE To assess ASD risk associated with intrauterine exposure to preexisting type 2 diabetes and gestational diabetes mellitus (GDM) by gestational age at GDM diagnosis.
DESIGN, SETTING, AND PATIENTS Retrospective longitudinal cohort study including 322 323 singleton children born in 1995-2009 at Kaiser Permanente Southern California (KPSC) hospitals. Children were tracked from birth until the first of the following: date of clinical diagnosis of ASD, last date of continuous KPSC health plan membership, death due to any cause, or December 31, 2012. Relative risks of ASD were estimated by hazard ratios (HRs) using Cox regression models adjusted for birth year.
EXPOSURES Maternal preexisting type 2 diabetes (n = 6496), GDM diagnosed at 26 weeks' gestation or earlier (n = 7456) or after 26 weeks' gestation (n = 17 579), or no diabetes (n = 290 792) during the index pregnancy.
MAIN OUTCOMES AND MEASURES Clinical diagnosis of ASD in offspring.
RESULTS During follow-up, 3388 children were diagnosed as having ASD (115 exposed to preexisting type 2 diabetes, 130 exposed to GDM at <= 26 weeks, 180 exposed to GDM at >26 weeks, and 2963 unexposed). Unadjusted annual ASD incidences were 3.26, 3.02, 1.77, and 1.77 per 1000 among children of mothers with preexisting type 2 diabetes, GDM diagnosed at 26 weeks or earlier, GDM diagnosed after 26 weeks, and no diabetes, respectively. The birth year-adjusted HRs were 1.59(95% Cl, 1.29-1.95) for preexisting type 2 diabetes, 1.63(95% Cl, 1.35-1.97) for GDM diagnosed at 26 weeks or earlier, and 0.98 (95% Cl, 0.84-1.15) for GDM diagnosed after 26 weeks relative to no exposure. After adjustment for maternal age, parity, education, household income, race/ethnicity, history of comorbidity, and sex of the child, maternal preexisting type 2 diabetes was not significantly associated with risk of ASD in offspring (HR, 1.21; 95% Cl, 0.97-1.52), but GDM diagnosed at 26 weeks or earlier remained so (HR, 1.42; 95% Cl, 1.15-1.74). Antidiabetic medication exposure was not independently associated with ASD risk. Adjustment for a mother or older sibling with ASD in the full cohort and for maternal smoking, prepregnancy body mass index, and gestational weight gain in the subset with available data (n = 68 512) did not affect the results.
CONCLUSIONS AND RELEVANCE In this large, multiethnic clinical cohort of singleton children born at 28 to 44 weeks' gestation, exposure to maternal GDM diagnosed by 26 weeks' gestation was associated with risk of ASD in offspring.
C1 [Xiang, Anny H.; Wang, Xinhui; Martinez, Maya P.; Coleman, Karen J.; Getahun, Darios] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA.
[Walthall, Johanna C.] Kaiser Permanente So Calif, Dept Psychiat, Pasadena, CA 91101 USA.
[Curry, Edward S.] Kaiser Permanente So Calif, Dept Pediat, Pasadena, CA 91101 USA.
[Page, Kathleen; Buchanan, Thomas A.] Univ So Calif, Keck Sch Med, Div Endocrinol & Diabet, Los Angeles, CA 90033 USA.
[Buchanan, Thomas A.] Univ So Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
[Getahun, Darios] Rutgers Robert Wood Johnson Med Sch, Dept Obstet & Gynecol, New Brunswick, NJ USA.
RP Xiang, AH (reprint author), Kaiser Permanente So Calif, Dept Res & Evaluat, 100 S Los Robles Ave,Fifth Floor, Pasadena, CA 91101 USA.
EM anny.h.xiang@kp.org
FU Kaiser Permanente Southern California Direct Community Benefit Funds
FX This work was supported by Kaiser Permanente Southern California Direct
Community Benefit Funds.
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NR 32
TC 1
Z9 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD APR 14
PY 2015
VL 313
IS 14
BP 1425
EP 1434
DI 10.1001/jama.2015.2707
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA CF8OK
UT WOS:000352821200017
PM 25871668
ER
PT J
AU de Paz, AM
Sanchez-Mut, JV
Samitier-Marti, M
Petazzi, P
Saez, M
Szczesna, K
Huertas, D
Esteller, M
Ausio, J
AF Martinez de Paz, Alexia
Vicente Sanchez-Mut, Jose
Samitier-Marti, Mireia
Petazzi, Paolo
Saez, Mauricio
Szczesna, Karolina
Huertas, Dori
Esteller, Manel
Ausio, Juan
TI Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes
SO PLOS ONE
LA English
DT Article
ID BINDING-PROTEIN 2; RETT-SYNDROME; MOUSE-BRAIN; BDNF TRANSCRIPTION;
NERVOUS-SYSTEM; CLOCK; EXPRESSION; SLEEP; MICE; PHOSPHORYLATION
AB Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome.
C1 [Martinez de Paz, Alexia; Vicente Sanchez-Mut, Jose; Samitier-Marti, Mireia; Petazzi, Paolo; Saez, Mauricio; Szczesna, Karolina; Huertas, Dori; Esteller, Manel; Ausio, Juan] Bellvitge Biomed Res Inst IDIBELL, PEBC, Barcelona, Catalonia, Spain.
[Esteller, Manel] Univ Barcelona, Sch Med, Dept Physiol Sci 2, Barcelona, Catalonia, Spain.
[Esteller, Manel] ICREA, Barcelona, Catalonia, Spain.
[Ausio, Juan] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC, Canada.
RP Esteller, M (reprint author), Bellvitge Biomed Res Inst IDIBELL, PEBC, Barcelona, Catalonia, Spain.
EM emesteller@idibell.cat; jausio@uvic.ca
FU European Community [PITN-GA2009-238242]; European Research Council
[268626]; E-RARE EuroRETT network (Carlos III Health Institute)
[PI071327]; Foundation Lejeune; MINECO [SAF2011 22803]; Catalan
Association of Rett Syndrome; Health and Science Department of the
Catalan Government (Generalitat de Catalunya); Canadian Institutes of
Health Research (CIHR) [MOP-97878]; Catalan Institution for Research and
Advanced Studies
FX Funding was provided by the European Community's Seven Framework
Programme (FP7/2007-2013) under grant agreement no PITN-GA2009-238242
DISCHROM project and by the European Research Council under grant
agreement no. 268626 EPINORC project, E-RARE EuroRETT network (Carlos
III Health Institute Project no PI071327), the Foundation Lejeune,
MINECO Project no SAF2011 22803, the Catalan Association of Rett
Syndrome, and the Health and Science Department of the Catalan
Government (Generalitat de Catalunya) (M.E.). Canadian Institutes of
Health Research (CIHR) [MOP-97878] grant (J.A.). M.E. is supported as a
Catalan Institution for Research and Advanced Studies Research
Professor.
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NR 50
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 13
PY 2015
VL 10
IS 4
DI 10.1371/journal.pone.0123693
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CF8XK
UT WOS:000352845100199
ER
PT J
AU Clement, S
Planchou, C
Beland, R
Motte, J
Samson, S
AF Clement, Sylvain
Planchou, Clement
Beland, Renee
Motte, Jacques
Samson, Severine
TI Singing abilities in children with Specific Language Impairment (SLI)
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE Specific Language Impairment; musical perception; musical production;
singing; pitch-matching
ID AUTISM SPECTRUM DISORDER; CONGENITAL AMUSIA; FREQUENCY DISCRIMINATION;
INHERITED SPEECH; NEURAL BASIS; MUSIC; DEFICIT; MEMORY; PITCH; BRAIN
AB Specific Language Impairment (SLI) is a heritable neurodevelopmental disorder diagnosed when a child has difficulties learning to produce and/or understand speech for no apparent reason (Bishop et al., 2012). The verbal difficulties of children with SLI have been largely documented, and a growing number of studies suggest that these children may also have difficulties in processing non-verbal complex auditory stimuli (Corriveau et al., 2007: Brandt et al., 2012). In a recent study, we reported that a large proportion of children with SLI present deficits in music perception (Planchou et al., under revision). Little is known, however, about the singing abilities of children with SLI. In order to investigate whether or not the impairments in expressive language extend to the musical domain, we assessed singing abilities in eight children with SLI and 15 children with Typical Language Development (TLD) matched for age and non-verbal intelligence. To this aim, we designed a ludic activity consisting of two singing tasks: a pitch-matching and a melodic reproduction task. In the pitch-matching task, the children were requested to sing single notes. In the melodic reproduction task, children were asked to sing short melodies that were either familiar (FAM-SONG and FAM-TUNE conditions) or unfamiliar (UNFAM-TUNE condition). The analysis showed that children with SLI were impaired in the pitch-matching task, with a mean pitch error of 250 cents (mean pitch error for children with TLD: 154 cents). In the melodic reproduction task, we asked 30 healthy adults to rate the quality of the sung productions of the children on a continuous rating scale. The results revealed that singing of children with SLI received lower mean ratings than the children with TLD. Our findings thus indicate that children with SLI showed impairments in musical production and are discussed in light of a general auditory-motor dysfunction in children with SLI.
C1 [Clement, Sylvain; Planchou, Clement; Samson, Severine] Univ Lille, UFR Psychol, Lab PSITEC, Neuropsychol Auditory Cognit Act Team, F-59653 Villeneuve Dascq, France.
[Planchou, Clement; Motte, Jacques] Amer Mem Hosp, Pole Femme Mere Enfant, Neurol Pediat, Reims, France.
[Beland, Renee] Univ Montreal, Ecole Orthophonie & Audiol, Montreal, PQ, Canada.
[Samson, Severine] Grp Hosp Pitie Salpetriere, Unite Epilepsie, F-75634 Paris, France.
RP Clement, S (reprint author), Univ Lille, UFR Psychol, BP60149,6 Rue Barreau, F-59653 Villeneuve Dascq, France.
EM sylvain.clement@univ-lille3.fr
FU Institut Universitaire de France; [ANR-09-BLAN-0310-02]
FX The authors are grateful to the children who gave their time ensuring
the study feasibility. This study has received funding from the French
Ministry (ANR-09-BLAN-0310-02), and the Institut Universitaire de France
to SS.
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NR 70
TC 0
Z9 0
PU FRONTIERS RESEARCH FOUNDATION
PI LAUSANNE
PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD APR 13
PY 2015
VL 6
AR 420
DI 10.3389/fpsyg.2015.00420
PG 11
WC Psychology, Multidisciplinary
SC Psychology
GA CF8MT
UT WOS:000352815800001
PM 25918508
ER
PT J
AU Zhang, R
Huang, M
Cao, ZJ
Qi, JY
Qiu, ZL
Chiang, LY
AF Zhang, Ran
Huang, Min
Cao, Zhijuan
Qi, Jieyu
Qiu, Zilong
Chiang, Li-Yang
TI MeCP2 plays an analgesic role in pain transmission through regulating
CREB/miR-132 pathway
SO Molecular Pain
LA English
DT Article
DE MeCP2; Acute pain; SNI model; Spinal cord; p-CREB/miR-132
ID CPG-BINDING PROTEIN-2; PERIPHERAL-NERVE INJURY; RETT-SYNDROME;
TRANSCRIPTIONAL REPRESSOR; MOLECULAR-MECHANISMS; DUPLICATION SYNDROME;
NEURAL PLASTICITY; INDUCED MICRORNA; INFLAMMATION; SENSITIVITY
AB Background: The Methyl CpG binding protein 2 gene (MeCP2 gene) encodes a critical transcriptional repressor and is widely expressed in mammalian neurons. MeCP2 plays a critical role in neuronal differentiation, neural development, and synaptic plasticity. Mutations and duplications of the human MECP2 gene lead to severe neurodevelopmental disorders, such as Rett syndrome and autism. In this study we investigate the role of MeCP2 in the spinal cord and found that MeCP2 plays an important role as an analgesic mediator in pain circuitry.
Findings: Experiments using MeCP2 transgenic mice showed that overexpression of MeCP2 weakens both acute mechanical pain and thermal pain, suggesting an analgesic role of MeCP2 in acute pain transduction. We found that through p-CREB/miR-132 signaling cascade is involved in MeCP2-mediated pain transduction. We also examined the role of MeCP2 in chronic pain formation using spared nerve injury (SNI) model. Strikingly, we found that development of neuropathic pain attenuates in MeCP2 transgenic mice comparing to wild type (WT) mice.
Conclusions: Our study shows that MeCP2 plays an analgesic role in both acute pain transduction and chronic pain formation through regulating CREB-miR-132 pathway. This work provides a potential therapeutic target for neural pathologic pain, and also sheds new lights on the abnormal sensory mechanisms associated with autism spectrum orders.
C1 [Zhang, Ran; Cao, Zhijuan; Qi, Jieyu; Chiang, Li-Yang] Southeast Univ, Inst Life Sci, Key Lab Dev Genes & Human Dis, Minist Educ, Nanjing, Jiangsu, Peoples R China.
[Qiu, Zilong] Chinese Acad Sci, Inst Neurosci, Key Lab Primate Neurobiol, Shanghai, Peoples R China.
[Huang, Min] Scripps Res Inst, Kellogg Sch Sci & Technol, La Jolla, CA 92037 USA.
RP Qiu, ZL (reprint author), Chinese Acad Sci, Inst Neurosci, Key Lab Primate Neurobiol, Shanghai, Peoples R China.
EM zqiu@ion.ac.cn; liyang.chiang@gmail.com
FU Southeast University's 985 grant; 973 Program [2011CBA00400]; Strategic
Priority Research Program of the Chinese Academy of Science
[XDB02050400]
FX We thank members of the Chiang and Qiu laboratories for advice and
comments on the manuscript. This work was supported by Southeast
University's 985 grant (L.Y.C), the 973 Program (2011CBA00400) and
Strategic Priority Research Program of the Chinese Academy of Science,
Grant No. XDB02050400 to Z.Q..
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NR 29
TC 0
Z9 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1744-8069
J9 MOL PAIN
JI Mol. Pain
PD APR 12
PY 2015
VL 11
DI 10.1186/s12990-015-0015-4
PG 7
WC Neurosciences
SC Neurosciences & Neurology
GA CG4TB
UT WOS:000353278600001
PM 25885346
ER
PT J
AU Pisula, E
Kawa, R
Danielewicz, D
Pisula, W
AF Pisula, Ewa
Kawa, Rafal
Danielewicz, Dorota
Pisula, Wojciech
TI The Relationship between Temperament and Autistic Traits in a
Non-Clinical Students Sample
SO PLOS ONE
LA English
DT Article
ID SPECTRUM QUOTIENT AQ; PERSONALITY-TRAITS; FUNCTIONING AUTISM;
GENERAL-POPULATION; MULTIPLE-INCIDENCE; PARENTS; PHENOTYPE; DISORDERS;
ADULTS; INDIVIDUALS
AB Since temperament affects the development of social behaviours and interpersonal relations, the possible links between autistic traits and temperament are of particular interest. The purpose of the study was to explore the relationships between autistic traits and temperamental characteristics in the framework of the Regulative Temperament Theory by Strelau, and the Emotionality, Activity and Sociability theory by Buss and Plomin, with particular emphasis on gender differences. The Autism Spectrum Quotient (AQ), Formal Characteristics of Behaviour - Temperament Inventory and Temperament Survey for Adults were administered. The participants were 593 university students, including 364 females and 229 males. Results showed positive correlations between autistic traits and Emotional Reactivity, Perseveration, Distress, Fear and Anger, and negative correlations with Activity, Briskness, Endurance and Sociability. The results of multiple regression analyses involving the Autism Spectrum Quotient score as a dependent measure were different for females and males. Results of exploratory PCA analysis showed that AQ score, Sociability and Activity loaded one factor (with AQ loading being opposite to two others). High AQ scorers demonstrated higher Emotional Reactivity, Perseveration, Distress and Anger, and lower Briskness, Endurance, Activity and Sociability as compared to norms for the general population. In this study we showed that temperament measures were able to identify items that correlated in parts with autistic traits, while other items were obverse. The relationships between temperament and autistic traits differ slightly between genders. We assume that with regard to the broader autism phenotype, temperaments might be helpful in characterizing healthy control samples.
C1 [Pisula, Ewa; Kawa, Rafal] Univ Warsaw, Fac Psychol, Warsaw, Poland.
[Danielewicz, Dorota] Maria Grzegorzewska Acad Special Educ, Inst Appl Psychol, Warsaw, Poland.
[Pisula, Wojciech] Polish Acad Sci, Inst Psychol, Warsaw, Poland.
RP Pisula, E (reprint author), Univ Warsaw, Fac Psychol, Warsaw, Poland.
EM ewa.pisula@psych.uw.edu.pl
FU Polish National Science Centre [N N106 352940]; Warsaw University
FX The study was supported by a grant from the Polish National Science
Centre (N N106 352940) and by the Warsaw University. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
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NR 59
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 10
PY 2015
VL 10
IS 4
AR e0124364
DI 10.1371/journal.pone.0124364
PG 19
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CF5II
UT WOS:000352590300136
PM 25860508
ER
PT J
AU Martinez-Jacobo, L
Ortiz-Lopez, R
Rizo-Mendez, A
Garcia-Molina, V
Santuario-Facio, SK
Rivas, F
Rojas-Martinez, A
AF Martinez-Jacobo, Lizeth
Ortiz-Lopez, Rocio
Rizo-Mendez, Alfredo
Garcia-Molina, Viridiana
Santuario-Facio, Sandra K.
Rivas, Fernando
Rojas-Martinez, Augusto
TI Clinical and molecular delineation of duplication 9p24.3q21.11 in a
patient with psychotic behavior
SO GENE
LA English
DT Article
DE 9p duplication syndrome; Psychosis; Autism
ID COPY NUMBER VARIATION; TRISOMY 9P; CHROMOSOME; SPECTRUM; DELETION;
GLYCINE; ORIGIN; AUTISM; REGION; GIRL
AB This article describes a 19-year-old female with mild facial dysmorphism, asociality, decreased school performance, and psychotic behavior in whom the karyotype showed an extra-chromosomal marker characterized as 9p24.3-9q21.11 duplication by array-CGH. The 69 Mbp duplicated segment in this patient includes the critical 9p duplication syndrome region, the GLDC and C90RF72 genes associated with psychotic behavior and other conduct disorders, and a potential locus for autism. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Martinez-Jacobo, Lizeth; Ortiz-Lopez, Rocio; Rojas-Martinez, Augusto] Univ Autonoma Nuevo Leon, Fac Med, Dept Bioquim &Med Mol, Monterrey 64460, Mexico.
[Ortiz-Lopez, Rocio; Santuario-Facio, Sandra K.; Rojas-Martinez, Augusto] Univ Autonoma Nuevo Leon, Unidad Genom, Ctr Invest & Desarrollo Ciencias Salud, Monterrey 64460, Mexico.
[Rizo-Mendez, Alfredo; Garcia-Molina, Viridiana] Hosp Civil Guadalajara, Serv Psiquiatria, Guadalajara, Mexico.
[Rivas, Fernando] Hosp Gen Occidente Seguro Social, Secretaria Salud Jalisco, Guadalajara, Mexico.
RP Rojas-Martinez, A (reprint author), Univ Autonoma Nuevo Leon, Fac Med, Colonia Mitras Ctr, Carlos Canseco S-N, Monterrey 64460, Mexico.
EM arojasmtz@gmail.com
RI ROJAS MARTINEZ, AUGUSTO/D-1710-2011
OI ROJAS MARTINEZ, AUGUSTO/0000-0003-3765-6778
FU CONACYT (Mexico)
FX We would like to thank the patient's mother for their cooperation along
this study. Lizeth Martinez-Jacobo is supported by a CONACYT (Mexico)
scholarship.
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NR 31
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD APR 10
PY 2015
VL 560
IS 1
BP 124
EP 127
DI 10.1016/j.gene.2015.02.010
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA CD2RQ
UT WOS:000350927100018
PM 25667990
ER
PT J
AU Byrge, L
Dubois, J
Tyszka, JM
Adolphs, R
Kennedy, DP
AF Byrge, Lisa
Dubois, Julien
Tyszka, J. Michael
Adolphs, Ralph
Kennedy, Daniel P.
TI Idiosyncratic Brain Activation Patterns Are Associated with Poor Social
Comprehension in Autism
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE autism spectrum disorder; default mode network; heterogeneity; machine
learning; naturalistic; social comprehension
ID SPECTRUM DISORDERS; FUNCTIONAL CONNECTIVITY; COGNITIVE NEUROSCIENCE;
NATURAL SCENES; CHILDREN; NETWORK; ADULTS; MIND; ORGANIZATION;
VARIABILITY
AB Autism spectrum disorder (ASD) features profound social deficits but neuroimaging studies have failed to find any consistent neural signature. Here we connect these two facts by showing that idiosyncratic patterns of brain activation are associated with social comprehension deficits. Human participants with ASD (N = 17) and controls (N = 20) freely watched a television situation comedy (sitcom) depicting seminaturalistic social interactions ("The Office", NBC Universal) in the scanner. Intersubject correlations in the pattern of evoked brain activation were reduced in the ASD group-but this effect was driven entirely by five ASD subjects whose idiosyncratic responses were also internally unreliable. The idiosyncrasy of these five ASD subjects was not explained by detailed neuropsychological profile, eye movements, or data quality; however, they were specifically impaired in understanding the social motivations of characters in the sitcom. Brain activation patterns in the remaining ASD subjects were indistinguishable from those of control subjects using multiple multivariate approaches. Our findings link neurofunctional abnormalities evoked by seminaturalistic stimuli with a specific impairment in social comprehension, and highlight the need to conceive of ASD as a heterogeneous classification.
C1 [Byrge, Lisa; Kennedy, Daniel P.] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA.
[Dubois, Julien; Tyszka, J. Michael; Adolphs, Ralph] CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA.
RP Byrge, L (reprint author), Indiana Univ, Dept Psychol & Brain Sci, 1101 East 10th St, Bloomington, IN 47405 USA.
EM lbyrge@indiana.edu; jcrdubois@gmail.com
FU National Institutes of Health [K99MH094409 / R00MH094409]; NARSAD from
Brain and Behavior Research Foundation; Simons Foundation [SFARI-07-01];
National Institutes of Mental Health Conte Center [P50MH094258];
National Science Foundation Graduate Research Fellowship
FX This work was supported by the National Institutes of Health Grant
K99MH094409 / R00MH094409 (D.P.K.), NARSAD Young Investigator Award from
the Brain and Behavior Research Foundation (D.P.K.), Simons Foundation
SFARI-07-01 (R.A.), National Institutes of Mental Health Conte Center
P50MH094258 (R.A.), and a National Science Foundation Graduate Research
Fellowship (L.B.). We thank Lynn K. Paul for assistance with clinical
diagnoses, Catherine Holcomb and Tim Armstrong for assistance with
scheduling and testing of participants, and Haley Gedek and Susannah
Burkholder for assistance in scoring the comprehension task.
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NR 61
TC 0
Z9 0
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD APR 8
PY 2015
VL 35
IS 14
BP 5837
EP 5850
DI 10.1523/JNEUROSCI.5182-14.2015
PG 14
WC Neurosciences
SC Neurosciences & Neurology
GA CG1SS
UT WOS:000353054900031
PM 25855192
ER
PT J
AU Foulkes, L
Bird, G
Gokcen, E
McCrory, E
Viding, E
AF Foulkes, Lucy
Bird, Geoffrey
Gokcen, Elif
McCrory, Eamon
Viding, Essi
TI Common and Distinct Impacts of Autistic Traits and Alexithymia on Social
Reward
SO PLOS ONE
LA English
DT Article
ID SPECTRUM DISORDERS; FACIAL EXPRESSIONS; CHILDREN; ADOLESCENTS;
DEPRESSION; INDIVIDUALS; RECOGNITION; IMPAIRMENTS; LONELINESS;
FRIENDSHIP
AB According to the social motivation hypothesis of autism, individuals with high levels of autistic traits experience reduced levels of reward from social interactions. However, empirical evidence to date has been mixed, with some studies reporting lower levels of social reward in individuals with Autism Spectrum Disorder (ASD), and others finding no difference when compared to typically developing controls. Alexithymia, a subclinical condition associated with the reduced ability to identify and describe one's own emotions, has been found to account for other affective difficulties observed inconsistently in individuals with ASD. The current study used a nonclinical sample (N = 472) to explore the associations between autistic traits and the value of six types of social reward, as measured by the Social Reward Questionnaire. In addition, we measured alexithymia to assess if this accounted for associations between autistic traits and social reward. There were three main findings. Firstly, higher levels of autistic traits were associated with significantly less enjoyment of admiration and sociability, and adding alexithymia to these models did not account for any additional variance. Secondly, both autistic traits and alexithymia were uniquely associated with reduced levels of enjoyment of prosocial interactions and sexual relationships. Thirdly, autistic traits were associated with higher levels of enjoyment of passivity and negative social potency, but these associations were no longer significant once alexithymia was taken into account, suggesting that co-occurring alexithymia accounted for these apparent associations. Overall, the current findings provide a novel and more nuanced picture of the relationship between autistic traits and social reward.
C1 [Foulkes, Lucy; Gokcen, Elif; McCrory, Eamon; Viding, Essi] UCL, Dept Clin Educ & Hlth Psychol, London, England.
[Bird, Geoffrey] Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, London, England.
[Bird, Geoffrey] UCL, Inst Cognit Neurosci, London, England.
RP Foulkes, L (reprint author), UCL, Dept Clin Educ & Hlth Psychol, London, England.
EM l.foulkes.11@ucl.ac.uk
FU UK Medical Research Council [MR/J500422/1]
FX This work was supported by a Four-Year PhD studentship in Mental Health
from the UK Medical Research Council (MR/J500422/1) awarded to LF. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
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NR 63
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 8
PY 2015
VL 10
IS 4
DI 10.1371/journal.pone.0121018
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CF3WA
UT WOS:000352478400026
PM 25853670
ER
PT J
AU Gregory, NJ
Lopez, B
Graham, G
Marshman, P
Bate, S
Kargas, N
AF Gregory, Nicola Jean
Lopez, Beatriz
Graham, Gemma
Marshman, Paul
Bate, Sarah
Kargas, Niko
TI Reduced Gaze Following and Attention to Heads when Viewing a "Live"
Social Scene
SO PLOS ONE
LA English
DT Article
ID JOINT VISUAL-ATTENTION; REAL-WORLD SCENES; EYE-MOVEMENTS; SACCADE
GENERATION; COGNITIVE-ETHOLOGY; CUES; INFORMATION; DIRECTION; AUTISM;
PERCEPTION
AB Social stimuli are known to both attract and direct our attention, but most research on social attention has been conducted in highly controlled laboratory settings lacking in social context. This study examined the role of social context on viewing behaviour of participants whilst they watched a dynamic social scene, under three different conditions. In two social groups, participants believed they were watching a live webcam of other participants. The socially-engaged group believed they would later complete a group task with the people in the video, whilst the non-engaged group believed they would not meet the people in the scene. In a third condition, participants simply free-viewed the same video with the knowledge that it was pre-recorded, with no suggestion of a later interaction. Results demonstrated that the social context in which the stimulus was viewed significantly influenced viewing behaviour. Specifically, participants in the social conditions allocated less visual attention towards the heads of the actors in the scene and followed their gaze less than those in the free-viewing group. These findings suggest that by underestimating the impact of social context in social attention, researchers risk coming to inaccurate conclusions about how we attend to others in the real world.
C1 [Gregory, Nicola Jean; Bate, Sarah] Bournemouth Univ, Fac Sci & Technol, Psychol Res Ctr, Poole BH12 5BB, Dorset, England.
[Gregory, Nicola Jean; Lopez, Beatriz; Graham, Gemma; Marshman, Paul; Kargas, Niko] Univ Portsmouth, Dept Psychol, Portsmouth, Hants, England.
RP Gregory, NJ (reprint author), Bournemouth Univ, Fac Sci & Technol, Psychol Res Ctr, Poole BH12 5BB, Dorset, England.
EM ngregory@bournemouth.ac.uk
FU Bournemouth University Fusion Investment Fund Staff Networking and
Mobility Award; Department of Psychology, University of Portsmouth
FX NG and SB were supported by a Bournemouth University Fusion Investment
Fund Staff Networking and Mobility Award. BL and NG were supported by a
research grant from the Department of Psychology, University of
Portsmouth. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
CR [Anonymous], 2013, DIAGNOSTIC AND STATI
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NR 67
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 8
PY 2015
VL 10
IS 4
DI 10.1371/journal.pone.0121792
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CF3WA
UT WOS:000352478400049
PM 25853239
ER
PT J
AU Kalinowska, M
Castillo, C
Francesconi, A
AF Kalinowska, Magdalena
Castillo, Catherine
Francesconi, Anna
TI Quantitative Profiling of Brain Lipid Raft Proteome in a Mouse Model of
Fragile X Syndrome
SO PLOS ONE
LA English
DT Article
ID AUTISM SPECTRUM DISORDERS; LEMLI-OPITZ-SYNDROME; DETERGENT-RESISTANT
MEMBRANES; LONG-TERM DEPRESSION; DE-NOVO MUTATIONS; LARGE GENE LISTS;
MESSENGER-RNAS; VISUAL-CORTEX; AMPA RECEPTOR; MICE LACKING
AB Fragile X Syndrome, a leading cause of inherited intellectual disability and autism, arises from transcriptional silencing of the FMR1 gene encoding an RNA-binding protein, Fragile X Mental Retardation Protein (FMRP). FMRP can regulate the expression of approximately 4% of brain transcripts through its role in regulation of mRNA transport, stability and translation, thus providing a molecular rationale for its potential pleiotropic effects on neuronal and brain circuitry function. Several intracellular signaling pathways are dysregulated in the absence of FMRP suggesting that cellular deficits may be broad and could result in homeostatic changes. Lipid rafts are specialized regions of the plasma membrane, enriched in cholesterol and glycosphingolipids, involved in regulation of intracellular signaling. Among transcripts targeted by FMRP, a subset encodes proteins involved in lipid biosynthesis and homeostasis, dysregulation of which could affect the integrity and function of lipid rafts. Using a quantitative mass spectrometry-based approach we analyzed the lipid raft proteome of Fmr1 knockout mice, an animal model of Fragile X syndrome, and identified candidate proteins that are differentially represented in Fmr1 knockout mice lipid rafts. Furthermore, network analysis of these candidate proteins reveals connectivity between them and predicts functional connectivity with genes encoding components of myelin sheath, axonal processes and growth cones. Our findings provide insight to aid identification of molecular and cellular dysfunctions arising from Fmr1 silencing and for uncovering shared pathologies between Fragile X syndrome and other autism spectrum disorders.
C1 [Kalinowska, Magdalena; Castillo, Catherine; Francesconi, Anna] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, New York, NY 10461 USA.
RP Francesconi, A (reprint author), Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, New York, NY 10461 USA.
EM anna.francesconi@einstein.yu.edu
FU Autism Speaks [7287]; NIH [MH082870]
FX This study was supported by a grant from Autism Speaks (grant # 7287),
www.autismspeaks.org; and NIH grant MH082870 to A.F. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
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NR 90
TC 0
Z9 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 7
PY 2015
VL 10
IS 4
AR e0121464
DI 10.1371/journal.pone.0121464
PG 23
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CF3VU
UT WOS:000352477800059
PM 25849048
ER
PT J
AU Bent, CA
Dissanayake, C
Barbaro, J
AF Bent, Catherine A.
Dissanayake, Cheryl
Barbaro, Josephine
TI Mapping the diagnosis of autism spectrum disorders in children aged
under 7 years in Australia, 2010-2012
SO MEDICAL JOURNAL OF AUSTRALIA
LA English
DT Article
AB Objectives: To investigate the frequency and age at diagnosis of autism spectrum disorder (ASD) in children aged under 7 years living in Australia.
Design and participants: Analysis of de-identified data on 15074 children aged under 7 years registered with the Helping Children with Autism Package (HCWAP; a program that provides funding for access to early intervention and support services throughout Australia) between 1 July 2010 and 30 June 2012.
Main outcome measures: Age at diagnosis of ASD as confirmed by a paediatrician, psychiatrist and/or multidisciplinary team assessment. Results: The average age at diagnosis of ASD in children registered with the HCWAP is currently 49 months, with the most frequently reported age being 71 months. Differences were evident in age at diagnosis across states, with children in Western Australia and New South Wales being diagnosed at a younger age. Across Australia, 0.74% of the population of children aged under 7 years are currently diagnosed with ASD and registered with the HCWAP. A higher proportion of children were registered with the HCWAP in Victoria compared with other states. There was no difference in age at diagnosis between Indigenous and non-Indigenous Australians, but children from a culturally and linguistically diverse background were diagnosed 5 months earlier than other children.
Conclusions: There may be a substantial gap between the age at which a reliable and accurate diagnosis of ASD is possible and the average age that children are currently diagnosed. The frequency of ASD diagnoses In Australia has increased substantially from previously published estimates.
C1 [Bent, Catherine A.; Dissanayake, Cheryl; Barbaro, Josephine] La Trobe Univ, Melbourne, Vic, Australia.
RP Bent, CA (reprint author), La Trobe Univ, Melbourne, Vic, Australia.
EM c.dissanayake@latrobe.edu.au
FU La Trobe University
FX Catherine Bent is supported by a La Trobe University Postgraduate
Research Scholarship.
NR 0
TC 0
Z9 0
PU AUSTRALASIAN MED PUBL CO LTD
PI PYRMONT
PA LEVEL 2, 26-32 PYRMONT BRIDGE RD, PYRMONT, NSW 2009, AUSTRALIA
SN 0025-729X
J9 MED J AUSTRALIA
JI Med. J. Aust.
PD APR 6
PY 2015
VL 202
IS 6
BP 317
EP 320
DI 10.5694/mja14.00328
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA CG6UO
UT WOS:000353438100027
PM 25832158
ER
PT J
AU Gecz, J
Corbett, M
AF Gecz, Jozef
Corbett, Mark
TI Developmental disorders: deciphering exomes on a grand scale
SO LANCET
LA English
DT Editorial Material
ID DE-NOVO MUTATIONS; INTELLECTUAL DISABILITY; INCIDENTAL FINDINGS;
DISEASE; AUTISM
C1 [Gecz, Jozef] Univ Adelaide, Womens & Childrens Hosp, Sch Paediat & Reprod Hlth, Adelaide, SA 5006, Australia.
Univ Adelaide, Womens & Childrens Hosp, Robinson Res Inst, Adelaide, SA 5006, Australia.
RP Gecz, J (reprint author), Univ Adelaide, Womens & Childrens Hosp, Sch Paediat & Reprod Hlth, Adelaide, SA 5006, Australia.
EM jozef.gecz@adelaide.edu.au
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NR 13
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Z9 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD APR 4
PY 2015
VL 385
IS 9975
BP 1266
EP 1267
DI 10.1016/S0140-6736(14)62122-X
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA CF0ZD
UT WOS:000352272400012
PM 25529583
ER
PT J
AU Klaver, JM
Dilalla, LF
AF Klaver, J. M.
Dilalla, L. F.
TI Psychological and Genetic Contributions to The Development of Social
Cognition in Children with and without Autism Spectrum Disorder
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PD APR 3
PY 2015
VL 29
IS 3
MA 126S
BP 370
EP 371
PG 2
WC Psychology, Clinical; Clinical Neurology; Psychology
SC Psychology; Neurosciences & Neurology
GA CI6KL
UT WOS:000354867800127
ER
PT J
AU Jashar, DT
Brennan, L
Robins, D
Barton, M
Fein, D
AF Jashar, D. T.
Brennan, L.
Robins, D.
Barton, M.
Fein, D.
TI Diagnostic Stability in Toddlers Who Lose An Autism Diagnosis in DSM-5
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PD APR 3
PY 2015
VL 29
IS 3
MA 127S
BP 371
EP 371
PG 1
WC Psychology, Clinical; Clinical Neurology; Psychology
SC Psychology; Neurosciences & Neurology
GA CI6KL
UT WOS:000354867800128
ER
PT J
AU Zoltowski, A
Heinrich, K
Ktiri, M
Badaly, D
Hodges, E
AF Zoltowski, A.
Heinrich, K.
Ktiri, M.
Badaly, D.
Hodges, E.
TI Social Cognition Measures and Their Relationship to Ratings of Social
Problems in Autism Spectrum Disorder
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PD APR 3
PY 2015
VL 29
IS 3
MA 128S
BP 371
EP 372
PG 2
WC Psychology, Clinical; Clinical Neurology; Psychology
SC Psychology; Neurosciences & Neurology
GA CI6KL
UT WOS:000354867800129
ER
PT J
AU Ludwig, NN
Abrams, DN
Fein, D
Adamson, LB
Robins, DL
AF Ludwig, N. N.
Abrams, D. N.
Fein, D.
Adamson, L. B.
Robins, D. L.
TI The Utility of Early Autism Spectrum Disorder (ASD) Screening Tools in
Predicting The Presence of ASD Symptoms and Symptom Severity
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PD APR 3
PY 2015
VL 29
IS 3
MA 129S
BP 372
EP 372
PG 1
WC Psychology, Clinical; Clinical Neurology; Psychology
SC Psychology; Neurosciences & Neurology
GA CI6KL
UT WOS:000354867800130
ER
PT J
AU Simpson, K
Keen, D
Lamb, J
AF Simpson, Kate
Keen, Deb
Lamb, Janeen
TI Teaching receptive labelling to children with autism spectrum disorder:
A comparative study using infant-directed song and infant-directed
speech
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE autism spectrum disorder; communication; music; children; intervention
ID PRESCHOOL-CHILDREN; COMMUNICATIVE DEVELOPMENT; PHYSIOLOGICAL-RESPONSES;
AUDITORY PREFERENCES; INTONATION CONTOURS; WORD RECOGNITION;
YOUNG-CHILDREN; LANGUAGE; MUSIC; MOTHERESE
AB Background There is a growing body of literature investigating the efficacy of music interventions for children with autism spectrum disorder (ASD); however, little empirical research has been conducted into the use of musical elements to facilitate language learning.
Methods This crossover-design study compared the responses of 22 children with ASD (M age = 5.88 years) to sung and spoken instructions embedded into a computer-based communication intervention designed to teach receptive labelling.
Results There was no significant difference between the sung and spoken conditions. Following both conditions, there was a significant increase in receptive labelling skills; skills were generalised and were maintained at follow-up. A difference in group performance was found.
Conclusion Further research is required to investigate child characteristics that may impact on children's performance using this approach.
C1 [Simpson, Kate; Lamb, Janeen] Australian Catholic Univ, Fac Educ & Arts, Brisbane, Qld, Australia.
[Simpson, Kate; Keen, Deb] Griffith Univ, Sch Educ & Profess Studies, Brisbane, Qld 4122, Australia.
RP Simpson, K (reprint author), Griffith Univ, Sch Educ & Profess Studies, Brisbane, Qld 4122, Australia.
EM k.simpson@griffith.edu.au
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NR 65
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1366-8250
EI 1469-9532
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD APR 3
PY 2015
VL 40
IS 2
BP 126
EP 136
DI 10.3109/13668250.2015.1014026
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CH3TM
UT WOS:000353953200003
ER
PT J
AU Layton, TL
Hao, G
Zou, XB
Li, L
Shao, Z
Yao, ML
Xu, X
Ke, XY
Wu, LJ
Zhou, JX
Jiang, ZM
AF Layton, Thomas L.
Hao, Grace
Zou, Xiaobing
Li, Ling
Shao, Zhi
Yao, Meiling
Xu, Xiu
Ke, Xiaoyan
Wu, Lijie
Zhou, Jiaxiu
Jiang, Zhimei
TI Differentiating low- and high-functioning children with autism spectrum
disorder, children with intellectual disability, and typically
developing children in a Chinese population
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE intellectual disability; Chinese; behaviours; lower and higher
functioning; autism spectrum disorder; assessment; domains
ID MENTAL-RETARDATION; UNITED-STATES; PREVALENCE; LANGUAGE; NETWORK;
PROFILE
AB Background There is a dearth of research or inconsistency in findings of behaviours among children with autism spectrum disorder (ASD) and children with intellectual disability (ID) as well as children who are typically developing (TD). This study compared 7 behavioural domains of 96 behaviours among Chinese children.
Method There were 803 children, including 426 children with low-functioning ASD (LFASD), 193 children with high-functioning ASD (HFASD), 128 children with ID, and 56 TD children. Ages ranged from 36 to 84 months. Each individual was administered the Chinese Autism Diagnostic Scale by a group of Chinese professionals.
Results All 7 domains were found to be more impaired for the children with ASD than the other groups. Three domains contained the most distinctive behaviours: Play behaviours, Social-Interactive behaviours, and Receptive Language behaviours. The Expressive Language domain was different for the LFASD group versus the group with ID.
Conclusion Children with ASD differed from children without ASD by several specific behaviours. These behaviours also differentiated performances by the children with HFASD and LFASD.
C1 [Layton, Thomas L.] T&T Commun Serv Inc, Durham, NC 27713 USA.
[Hao, Grace] N Carolina Cent Univ, Dept Allied Hlth Profess, Durham, NC USA.
[Zou, Xiaobing] Sun Yet sen Univ, Dept Pediat Dev Disorders, Affiliated Hosp 3, Guangzhou, Peoples R China.
[Li, Ling] Hainan Peoples Hosp, Dept Pediat, Haikou, Peoples R China.
[Shao, Zhi] Chongqing Ninth Peoples Hosp, Dept Pediat, Chongqing, Peoples R China.
[Yao, Meiling] Zhengzhou Univ, Pediat Rehabil Dept, Affiliated Hosp 3, Zhengzhou 450052, Peoples R China.
[Xu, Xiu] Shanghai Fudan Univ, Dept Pediat Dev Disorders, Affiliated Childrens Hosp, Shanghai, Peoples R China.
[Ke, Xiaoyan] Nanjing Med Univ, Res Inst Pediat Psychol Disorders, Nanjing Brain Hosp Affiliated, Nanjing, Jiangsu, Peoples R China.
[Wu, Lijie] Harbin Med Univ, Autism Res Ctr, Coll Publ Hlth, Harbin, Peoples R China.
[Zhou, Jiaxiu] Shenzhen Childrens Hosp, Shenzhen Pediat Dept, Shenzhen, Peoples R China.
[Jiang, Zhimei] Jiamusi Univ, Rehabil Med, Affiliated Hosp 3, Jiamusi, Heilongjiang, Peoples R China.
RP Layton, TL (reprint author), T&T Commun Serv Inc, 100 Meredith Dr,Suite 100, Durham, NC 27713 USA.
EM tandtcommunication@earthlink.net
CR American Psychiatric Association, 2000, DIAGN STAT MENT DIS, V4th
American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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Tsatsanis K., 2005, HDB AUTISM PERVASIVE, V1, P365
Wechsler D, 2010, WECHSLER INTELLIGENC
Zhang X, 2005, BIOMED ENVIRON SCI, V18, P334
NR 32
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1366-8250
EI 1469-9532
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD APR 3
PY 2015
VL 40
IS 2
BP 137
EP 146
DI 10.3109/13668250.2015.1022514
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CH3TM
UT WOS:000353953200004
ER
PT J
AU Hidalgo, NJ
McIntyre, LL
McWhirter, EH
AF Hidalgo, Nina Jamilette
McIntyre, Laura Lee
McWhirter, Ellen Hawley
TI Sociodemographic differences in parental satisfaction with an autism
spectrum disorder diagnosis
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE diagnosis; parent satisfaction; autism spectrum disorder; maternal
education; ASD; family income
ID SOCIOECONOMIC-STATUS; CHILDREN; HEALTH; RISK; INTERVENTION;
EPIDEMIOLOGY; SERVICES; STRESS; RACE; SES
AB Background The diagnostic process for autism spectrum disorder (ASD) can be difficult for families. Growing evidence suggests that the diagnostic process may vary as a function of sociodemographic factors, such as socioeconomic status. The purpose of this study was to extend findings related to families' experiences obtaining a diagnosis and accessing services for their young child with ASD.
Method A mixed methods approach was used in this study, in which 46 families with children with ASD participated. A chi-square analysis compared ratings of parental satisfaction with the diagnostic process and current services between sociodemographic groups, and this was supplemented by thematic analysis of relevant open-ended questions.
Results Results indicated that satisfaction ratings varied significantly by maternal education and family income levels. Ratings of satisfaction with the child's paediatrician also differed by family income. Major themes from the open-ended questions are discussed.
Conclusions Results support assessing satisfaction and barriers in families seeking healthcare and school-based services to facilitate access to services.
C1 [Hidalgo, Nina Jamilette; McWhirter, Ellen Hawley] Univ Oregon, Dept Counseling Psychol & Human Serv, Eugene, OR 97403 USA.
[McIntyre, Laura Lee] Univ Oregon, Dept Special Educ & Clin Sci, Eugene, OR 97403 USA.
RP McIntyre, LL (reprint author), 5208 Univ Oregon, Dept Special Educ & Clin Sci, Eugene, OR 97403 USA.
EM llmcinty@uoregon.edu
FU Fairway Foundation; National Institutes of Health [R01 HD059838]
FX This research was funded in part by a grant from the Fairway Foundation
and the National Institutes of Health (R01 HD059838) awarded to the
second author.
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American Psychiatric Association, 2013, DIAGN STAT MAN MENT
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NR 26
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1366-8250
EI 1469-9532
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD APR 3
PY 2015
VL 40
IS 2
BP 147
EP 155
DI 10.3109/13668250.2014.994171
PG 9
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CH3TM
UT WOS:000353953200005
ER
PT J
AU Derguy, C
Michel, G
M'bailara, K
Roux, S
Bouvard, M
AF Derguy, Cyrielle
Michel, Gregory
M'bailara, Katia
Roux, Solenne
Bouvard, Manuel
TI Assessing needs in parents of children with autism spectrum disorder: A
crucial preliminary step to target relevant issues for support programs
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE parent support; autism spectrum disorder (ASD); parenting needs;
therapeutic education
ID DEVELOPMENTAL-DISABILITIES; PRESCHOOL-CHILDREN; FAMILIES; STRESS;
EXPERIENCES; BEHAVIORS; INFANTS; MOTHERS; QUALITY; HEALTH
AB Background Raising a child with an autism spectrum disorder (ASD) implies significant stress levels and changes in family functioning. Most studies deal with parental difficulties, whereas those focusing on parental self-reported support needs related to ASD are fewer, especially in France. Our objective was to explore in a French sample the needs of parents of children with ASD so as to provide recommendations for support.
Method Parents were interviewed (N = 162, including 84 controls), and content analysis was performed from parental responses.
Results Six dimensions of need emerged: material, information, guidance, daily management, relational support, and emotional support. Needs priorities were different for parents with a child with ASD involving the transmission of knowledge and skills as well as emotional and relational support.
Conclusions This study highlights the need to develop support programs focused on the needs of the parents that reflect educational, behavioural, and psychological dimensions.
C1 [Derguy, Cyrielle; Michel, Gregory; M'bailara, Katia; Roux, Solenne] Univ Bordeaux, Dept Psychol Hlth & Qual Life, F-33076 Bordeaux, France.
[Derguy, Cyrielle; Bouvard, Manuel] Charles Perrens Hosp, Expert Autism Ctr, Bordeaux, France.
[Bouvard, Manuel] Univ Bordeaux, Aquitaine Inst Cognit & Integrat Neurosci INCIA, F-33076 Bordeaux, France.
RP Derguy, C (reprint author), Univ Bordeaux, Dept Psychol Hlth & Qual Life, EA 4139, 3Ter Pl Victoire, F-33076 Bordeaux, France.
EM cyrielle.derguy@u-bordeaux.fr
FU Orange Foundation, Paris, France
FX This study received financial support from the Orange Foundation, Paris,
France. The Orange Foundation has not imposed any restrictions on free
access to or publication of the research data. There are no conflicts of
interest for any of the authors.
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NR 48
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1366-8250
EI 1469-9532
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD APR 3
PY 2015
VL 40
IS 2
BP 156
EP 166
DI 10.3109/13668250.2015.1023707
PG 11
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CH3TM
UT WOS:000353953200006
ER
PT J
AU Dix, L
Fallows, R
Murphy, G
AF Dix, Leigh
Fallows, Rachael
Murphy, Glynis
TI Effectiveness of the ADEC as a Level 2 screening test for young children
with suspected autism spectrum disorders in a clinical setting
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE early detection; ADEC; autism; screening
ID EARLY-CHILDHOOD ADEC; 2-YEAR-OLDS STAT; TODDLERS; TOOL; INTERVENTION;
MANAGEMENT; INFANTS; RISK
AB Background The Autism Detection in Early Childhood (ADEC) is a clinician-administered, Level 2 screening tool. A retrospective file audit was used to investigate its clinical effectiveness.
Method Toddlers referred to an Australian child development service between 2008 and 2010 (N = 53, M age = 32.2 months) were screened with the ADEC. Their medical records were reviewed in 2013 when their mean age was 74.5 months, and the original ADEC screening results were compared with later diagnostic outcomes.
Results The ADEC had good sensitivity (87.5%) and moderate specificity (62%). Three behaviours predicted autism spectrum disorders (ASDs): response to name, gaze switching, and gaze monitoring (p <= .001).
Conclusions The ADEC shows promise as a screening tool that can discriminate between young children with ASDs and those who have specific communication disorders or developmental delays that persist into middle childhood but who do not meet the criteria for ASDs.
C1 [Dix, Leigh; Fallows, Rachael] WA Hlth, Child & Adolescent Community Hlth, Perth, WA, Australia.
[Murphy, Glynis] Univ Kent, Tizard Ctr, Canterbury, Kent, England.
RP Dix, L (reprint author), Bentley Child Dev Serv, Cnr Andrea Way & Treasure Rd, Queens Pk, WA 6107, Australia.
EM leigh.dix@health.wa.gov.au
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NR 32
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1366-8250
EI 1469-9532
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD APR 3
PY 2015
VL 40
IS 2
BP 179
EP 188
DI 10.3109/13668250.2015.1014323
PG 10
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CH3TM
UT WOS:000353953200008
ER
PT J
AU Jung, S
Sainato, DM
AF Jung, Sunhwa
Sainato, Diane M.
TI Teaching games to young children with autism spectrum disorder using
special interests and video modelling
SO JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
LA English
DT Article
DE autism spectrum disorder; social skills; video modelling; social
engagement; play skills; restricted interests
ID POWER CARD STRATEGY; OF-THE-LITERATURE; PRETEND PLAY; SOCIODRAMATIC
PLAY; SOCIAL PLAY; SKILLS; PRESCHOOLERS; DISABILITIES; BEHAVIORS;
INTERVENTION
AB Background Children with autism spectrum disorder (ASD) may exhibit delayed play skills or repetitive play and have difficulty engaging in spontaneous play with peers.
Method A multiple-probe design across participants was used to investigate the effectiveness of a video modelling intervention and the use of children's special interests on their engagement with games and with peers for kindergarten children with ASD.
Results Results indicated that all three children with ASD demonstrated increased engagement with the games and social engagement with their peers. Inappropriate behaviour decreased with the intervention. The effects were maintained during the follow-up and generalised to a novel game. Social validity data indicated that the study was meaningful and the intervention was feasible and effective.
Conclusion Future research should focus on designing play skills interventions that serve to motivate both children with ASD and their typically developing peers in order to promote more spontaneous and interactive play among them.
C1 [Jung, Sunhwa] Otterbein Univ, Dept Educ, Westerville, OH 43081 USA.
[Sainato, Diane M.] Ohio State Univ, Dept Educ Studies, Columbus, OH 43210 USA.
RP Jung, S (reprint author), Otterbein Univ, Dept Educ, Westerville, OH 43081 USA.
EM sjung@otterbein.edu
FU George W. and Mildred K. White Faculty Endowment Fund; Otterbein
University
FX This research study was supported in part by the George W. and Mildred
K. White Faculty Endowment Fund, and the Otterbein University sabbatical
fund.
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NR 60
TC 0
Z9 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1366-8250
EI 1469-9532
J9 J INTELLECT DEV DIS
JI J. Intellect. Dev. Dis.
PD APR 3
PY 2015
VL 40
IS 2
BP 198
EP 212
DI 10.3109/13668250.2015.1027674
PG 15
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA CH3TM
UT WOS:000353953200010
ER
EF