FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Chen, Y
Qiu, JH
Chen, FQ
Liu, SL
AF Chen, Yang
Qiu, Jianhua
Chen, Fuquan
Liu, Shunli
TI Migration of neural precursor cells derived from olfactory bulb in
cochlear nucleus exposed to an augmented acoustic environment
SO HEARING RESEARCH
LA English
DT Article
DE stem cells; olfactory bulb; cochlear nucleus; neuron; transplantation;
augmented acoustic environment
ID ADULT MAMMALIAN BRAIN; EMBRYONIC STEM-CELLS; PROGENITOR CELLS;
SUBVENTRICULAR ZONE; NEURONAL DIFFERENTIATION; PROLONGED EXPOSURE;
AUDITORY FUNCTION; C57BL/6J MICE; HEARING-LOSS; DBA/2J MICE
AB The regeneration of the auditory neural system remains a challenge in hearing restoration. Acoustic signals may induce a site-specific cell replacement in the auditory system. This hypothesis was tested with grafted implantation of neural precursor cells (NPCs) along the cochlear nucleus in the adult host followed by an augmented acoustic stimulation. NPCs were obtained from the olfactory bulbs at embryonic day 14-16 and were transplanted into the inside border of cochlear nucleus. The labeled cells survived at least 2 weeks, verified by Hoechst 33342 fluorescence, and by immunostaining for a neuronal marker. In some cases NPCs had migrated directionally to the root of the auditory nerve. This observation demonstrates the survival and migration of NPCs from the olfactory bulb (013) along the adult auditory nerve in an augmented acoustic environment following implantation. (c) 2006 Published by Elsevier B.V.
C1 Fourth Mil Med Univ, Dept Otolaryngol, Xijing Hosp, Xian 710032, Peoples R China.
RP Qiu, JH (reprint author), Fourth Mil Med Univ, Dept Otolaryngol, Xijing Hosp, Xian 710032, Peoples R China.
EM qiujh@fmmu.edu.cn
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NR 34
TC 10
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 3
EP 10
DI 10.1016/j.heares.2006.11.014
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900002
PM 17467207
ER
PT J
AU Polimeni, M
Prigioni, I
Russo, G
Calzi, D
Gioglio, L
AF Polimeni, Mariarosa
Prigioni, Ivo
Russo, Giancarlo
Calzi, Daniela
Gioglio, Luciana
TI Plasma membrane Ca2+-ATPase isoforms in frog crista ampullaris:
Identification of PMCA1 and PMCA2 specific splice variants
SO HEARING RESEARCH
LA English
DT Article
DE frog; semicircular canal; crista ampullaris; hair cells; calcium pump;
isozymes
ID VESTIBULAR HAIR-CELLS; MECHANOELECTRICAL-TRANSDUCTION; CALCIUM-PUMP;
CA-ATPASE; NA+-CA2+ EXCHANGE; ION CHANNELS; GUINEA-PIG; ADAPTATION;
CURRENTS; STEREOCILIA
AB Ca2+ ions play a pivotal role in inner ear hair cells as they are involved from the mechano-electrical transduction to the transmitter release. Most of the Ca2+ that enters into hair cells via mechano-transduction and voltage-gated channels is extruded by the plasma membrane Ca2+-ATPases (PMCAs) that operate in both apical and basal cellular compartments. Here, we determined the identity and distribution of PMCA isoforms in frog crista ampullaris: we showed that PMCA1, PMCA2 and PMCA3 are expressed, while PMCA4 appears to be negligible. We also identify PMCA1bx, PMCA2av and PMCA2bv as the major splice variants produced from PMCA1 and PMCA2 genes. PMCA2av appears to be the major Ca2+-pump operating at the apical pole of the cell, even if PMCA1b is also expressed in the stereocilia. PMCA1bx is, instead, the principal PMCA of hair cell basolateral compartment, where it is expressed together with PMCA2 (probably PMCA2bv) and PMCA3.
Frog crista ampullaris hair cells lack a Na/Ca exchanger, therefore PMCAs are the only mechanism of Ca2+ extrusion. The coexpression of specific isozymes in the different cellular compartments responds to the need of a fine regulation of both basal and dynamic Ca2+ levels at the apical and basal pole of the cell. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Pavia, Dipartimento Med Sperimentale, Sez Anat Umana Normale, I-27100 Pavia, Italy.
Univ Pavia, Dipartimento Sci Fisiol Farmacol Cellulari & Mol, I-27100 Pavia, Italy.
RP Polimeni, M (reprint author), Univ Pavia, Dipartimento Med Sperimentale, Sez Anat Umana Normale, Via Forlanini 8, I-27100 Pavia, Italy.
EM polimeni@unipv.it; prigioi@unipv.it; gianca@unipv.it; dcalzi@libero.it;
lucy@unipv.it
RI Polimeni, Mariarosa/B-6036-2012
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NR 49
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 11
EP 21
DI 10.1016/j.heares.2006.12.016
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900003
PM 17336006
ER
PT J
AU Sneary, MG
Lewis, ER
AF Sneary, Michael G.
Lewis, Edwin R.
TI Tuning properties of turtle auditory nerve fibers: Evidence for
suppression and adaptation
SO HEARING RESEARCH
LA English
DT Article
DE turtle ear; auditory nerve fibers; Wiener-kernel analysis; suppression;
high-order tuning
ID WIENER-KERNEL ANALYSIS; COCHLEAR HAIR-CELLS; TEMPORAL RECEPTIVE-FIELD;
INNER-EAR FUNCTION; GAUSSIAN-NOISE; SINGLE UNITS; RESPONSES; BULLFROG;
INHIBITION; EXCITATION
AB Second-order reverse correlation (second-order Wiener-kernel analysis) was carried out between spike responses in single afferent units from the basilar papilla of the red-eared turtle and band limited white noise auditory stimuli. For units with best excitatory frequencies (BEFs) below approximately 500 Hz, the analysis revealed suppression similar to that observed previously in anuran amphibians. For units with higher BEFs, the analysis revealed de response with narrow-band tuning centered about the BEF, combined with broad-band ac response at lower frequencies. For all units, the analysis revealed the relative timing and tuning of excitation and various forms of inhibitory or suppressive effects. (c) 2007 Elsevier B.V. All rights reserved.
C1 San Jose State Univ, Dept Biol Sci, San Jose, CA 95192 USA.
Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA.
RP Sneary, MG (reprint author), San Jose State Univ, Dept Biol Sci, San Jose, CA 95192 USA.
EM msneary@email.sjsu.edu
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NR 49
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 22
EP 30
DI 10.1016/j.heares.2006.12.014
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900004
PM 17331685
ER
PT J
AU Friedland, DR
Eernisse, R
Popper, P
AF Friedland, David R.
Eernisse, Rebecca
Popper, Paul
TI Potassium channel gene expression in the rat cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE cochlear nucleus; gene expression; SAGE; potassium channels; Kv3.2;
Kir7.1
ID RETINAL-PIGMENT EPITHELIUM; K+ CHANNEL; DIFFERENTIAL EXPRESSION; SERIAL
ANALYSIS; DOMINANT DEAFNESS; ALPHA-SUBUNITS; NERVOUS-SYSTEM; OCTOPUS
CELLS; FAST-SPIKING; NEURONS
AB Potassium channels play a critical role in defining the electrophysiological properties accounting for the unique response patterns of auditory neurons. Serial analysis of gene expression (SAGE), microarrays, RT-PCR, and real-time RT-PCR were used to generate a broad profile of potassium channel expression in the rat cochlear nucleus. This study identified mRNAs for 51 different potassium channel subunits or channel interacting proteins. The relative expression levels of 27 of these transcripts among the AVCN, PVCN, and DCN were determined by real-time RT-PCR. Four potassium channel transcripts showed substantial levels of differential expression. Kcnc2 was expressed more than 15-fold higher in the DCN as compared to AVCN and PVCN. In contrast, Kcnj13 had an approximate 10-fold higher expression in AVCN and PVCN than in DCN. Two subunits that modify the activity of other channels were inversely expressed between ventral and dorsal divisions. Kcns1 was over 15-fold higher in DCN than AVCN or PVCN, while Kcns3 was about 25-fold higher in AVCN than in DCN. The expression patterns of potassium channels in the subdivisions of the cochlear nucleus provide a basis for understanding the electrophysiological mechanisms which sub-serve central auditory processing and provide targets for further investigations into neural plastic changes that occur with hearing loss. (c) 2007 Elsevier B.V. All rights reserved.
C1 Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, Milwaukee, WI 53226 USA.
RP Friedland, DR (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
EM dfriedla@mcw.edu
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ZOU A, 2003, CELL PHYSL, V285, pC1356
NR 44
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 31
EP 43
DI 10.1016/j.heares.2007.01.024
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900005
PM 17346910
ER
PT J
AU Harris, KC
Mills, JH
Dubno, JR
AF Harris, Kelly C.
Mills, John H.
Dubno, Judy R.
TI Electrophysiologic correlates of intensity discrimination in cortical
evoked potentials of younger and older adults
SO HEARING RESEARCH
LA English
DT Article
DE aging and cortical potentials; auditory evoked potentials; aging and
intensity discrimination
ID EVENT-RELATED POTENTIALS; AGE-RELATED-CHANGES; AMPLITUDE-MODULATED
STIMULI; RAT INFERIOR COLLICULUS; PRIMARY AUDITORY-CORTEX; HEARING-LOSS;
NEURAL REPRESENTATION; MISMATCH NEGATIVITY; FREQUENCY; RESPONSES
AB When measured behaviorally, older adults with normal hearing have poorer intensity discrimination thresholds than younger adults, but only at lower frequencies. Poor intensity discrimination at lower but not higher frequencies for older adults can be associated with an age-related decline in temporal processing. The current study was designed to assess age-related effects on intensity discrimination at 500 and 3000 Hz using the cortical auditory evoked potential, N1-P2. Subjects were 10 younger and 10 older adults with normal hearing. The N1-P2 was elicited by an intensity. increase in an otherwise continuous pure tone presented at 70 dB SPL. Intensity increments ranged from 0 dB to 5 dB at 500 Hz and from 0 dB to 8 dB at 3000 Hz in l-dB steps. Intensity discrimination threshold was defined as the smallest intensity change needed to evoke an N1-P2 response. Consistent with behavioral measures, N1-P2 response thresholds were significantly higher for older subjects than younger subjects at 500 Hz but did not differ significantly at 3000 Hz. In addition, NI and P2 latencies for older subjects were significantly prolonged at 500 Hz, but not at 3000 Hz. As intensity increments increased above threshold, amplitudes tended to be larger in older than in younger subjects, however, these differences were not statistically significant. In older subjects, response latencies and amplitudes were significantly larger at 500 Hz than at 3000 Hz. In younger subjects, response latencies and amplitudes were similar across frequency. Similar intensity discrimination thresholds and age-related differences for behavioral measures and evoked potentials support the notion that the N1-P2 measures reflect the physiological detection of intensity change which in turn relates to intensity discrimination. A possible explanation for the decreased intensity discrimination at low frequencies, and enhanced amplitudes with prolonged latencies in older subjects is an age-related decline in inhibitory control within the central auditory nervous system. (c) 2007 Elsevier B.V. All rights reserved.
C1 Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
RP Harris, KC (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,POB 250550, Charleston, SC 29425 USA.
EM harriskc@musc.edu
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NR 60
TC 20
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 58
EP 68
DI 10.1016/j.heares.2007.01.021
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900007
PM 17344001
ER
PT J
AU Razak, KA
Fuzessery, ZM
AF Razak, Khaleel A.
Fuzessery, Zoltan M.
TI Development of functional organization of the pallid bat auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE development; auditory cortex; feature maps; binaural selectivity; pallid
bat; tonotopy
ID INTERAURAL INTENSITY DIFFERENCES; PASSIVE SOUND LOCALIZATION; INFERIOR
COLLICULUS; BINAURAL ORGANIZATION; ANTROZOUS-PALLIDUS; RECEPTIVE-FIELDS;
RESPONSE SELECTIVITY; CORTICAL-NEURONS; CAT; SENSITIVITY
AB The primary auditory cortex is characterized by a tonotopic map and a clustered organization of binaural properties. The factors involved in the development of overlain representation of these two properties are unclear. We addressed this issue in the auditory cortex of the pallid bat. The adult pallid bat cortex contains a systematic relationship between best frequency (BF) and binaural properties. Most neurons with BF < 30 kHz are binaurally inhibited (EO/I), while most neurons with BF > 30 kHz are monaural (EO). As in other species, binaural properties are clustered. The EO/I cluster contains a systematic map of interaural intensity difference (IID) sensitivity. We asked if these properties are present at the time the bat acquires its full audible range (postnatal day [P] 15). Tonotopy, relationship between BF and binaural properties, and the map of IID sensitivity are adult-like at P15. However, binaural facilitation is only observed in pups older than P25. Frequency selectivity shows a BF-dependent sharpening during development. Thus, overlain representation of binaural properties and tonotopy in the pallid bat cortex is remarkably adult-like at an age when the full audible range is first present, suggesting an experience-independent development of overlapping feature maps. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Wyoming, Dept Zool & Physiol, Laramie, WY 82071 USA.
RP Fuzessery, ZM (reprint author), Univ Wyoming, Dept Zool & Physiol, Laramie, WY 82071 USA.
EM zmf@uwyo.edu
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NR 45
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 69
EP 81
DI 10.1016/j.heares.2007.01.020
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900008
PM 17321705
ER
PT J
AU Hall, IC
Hurley, LM
AF Hall, Ian C.
Hurley, Laura M.
TI The serotonin releaser fenfluramine alters the auditory responses of
inferior colliculus neurons
SO HEARING RESEARCH
LA English
DT Article
DE fenfluramine; serotonin; serotonin receptor; inferior colliculus;
neuromodulation
ID DORSAL RAPHE NUCLEUS; RAT PREFRONTAL CORTEX; GUINEA-PIG BRAIN; COCHLEAR
NUCLEUS; 5-HYDROXYTRYPTAMINE SEROTONIN; EXTRACELLULAR SEROTONIN;
FUNCTIONAL-ORGANIZATION; MODULATES RESPONSES; RECEPTORS; SYSTEM
AB Local direct application of the neuromodulator serotonin strongly influences auditory response properties of neurons in the inferior colliculus (IC), but endogenous stores of serotonin may be released in a distinct spatial or temporal pattern. To explore this issue, the serotonin releaser fenfluramine was iontophoretically applied to extracellularly recorded neurons in the IC of the Mexican free-tailed bat (Tadarida brasiliensis). Fenfluramine mimicked the effects of serotonin on spike count and first spike latency in most neurons, and its effects could be blocked by co-application of serotonin receptor antagonists, consistent with fenfluramine-evoked serotonin release. Responses to fenfluramine did not vary during single applications or across multiple applications, suggesting that fenfluramine did not deplete serotonin stores. A predicted gradient in the effects of fenfluramine with scrotonin fiber density was not observed, but neurons with fenfluramine-evoked increases in latency occurred at relatively greater recording depths compared to other neurons with similar characteristic frequencies. These findings support the conclusion that there may be spatial differences in the effects of exogenous and endogenous sources of serotonin, but that other factors such as the identities and locations of serotonin receptors are also likely to play a role in determining the dynamics of serotonergic effects. (c) 2007 Elsevier B.V. All rights reserved.
C1 Indiana Univ, Dept Biol, Bloomington, IN 47405 USA.
RP Hall, IC (reprint author), Indiana Univ, Dept Biol, 1001 E 3rd St,342 Jordan Hall, Bloomington, IN 47405 USA.
EM ichall@indiana.edu; lhurley@indiana.edu
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NR 71
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 82
EP 94
DI 10.1016/j.heares.2007.01.023
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900009
PM 17339086
ER
PT J
AU Zhi, M
Ratnanather, JT
Ceyhan, E
Popel, AS
Brownell, WE
AF Zhi, Man
Ratnanather, J. Tilak
Ceyhan, Elvan
Popel, Aleksander S.
Brownell, William E.
TI Hypotonic swelling of salicylate-treated cochlear outer hair cells
SO HEARING RESEARCH
LA English
DT Article
DE hydraulic conductivity; extracisternal space; subsurface cisterna
ID GUINEA-PIG COCHLEA; LATERAL WALL; PLASMA-MEMBRANE; HYDRAULIC
CONDUCTIVITY; WATER PERMEABILITY; BENDING STIFFNESS; ELASTIC-MODULI;
MOTOR PROTEIN; ELECTROMOTILITY; MODEL
AB The outer hair cell (OHC) is a hydrostat with a low hydraulic conductivity of P-f = 3 x 10(-4) cm/s across the plasma membrane (PM) and subsurface cisterna that make up the OHC's lateral wall. The SSC is structurally and functionally a transport barrier in normal cells that is known to be disrupted by salicylate. The effect of sodium salicylate on P-f is determined from osmotic experiments in which isolated, control and salicylate-treated OHCs were exposed to hypotonic solutions in a constant flow chamber. The value of P-f = 3.5 +/- 0.5 x 10(-4) cm/s (mean +/- s.c.m., n = 34) for salicylate-treated OHCs was not significantly different from P-f = 2.4 +/- 0.3 x 10(-4) cm/s (mean +/- s.e.m., n = 31) for untreated OHCs (p =.3302). Thus Pf is determined by the PM and is unaffected by salicylate treatment. The ratio of longitudinal strain to radial strain epsilon(z)/epsilon(c) = -0.76 for salicylate-treated OHCs was significantly smaller (P = .0 143) from -0.72 for untreated OHCs, and is also independent of the magnitude of the applied osmotic challenge. Salicylate-treated OHCs took longer to attain a steady-state volume which is larger than that for untreated OHCs and increased in volume by 8-15% prior to hypotonic perfusion unlike sodium alpha-ketoglutarate-treated OHCs. It is suggested that depolymerization of cytoskeletal proteins and/or glycogen may be responsible for the large volume increase in salicylate-treated OHCs as well as the different responses to different modes of application of the hypotonic solution. (c) 2007 Elsevier B.V. All rights reserved.
C1 Johns Hopkins Univ, Ctr Imaging Sci, Whitaker Biomed Engn Inst, Baltimore, MD 21218 USA.
Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, Houston, TX 77030 USA.
Johns Hopkins Univ, Inst Computat Med, Baltimore, MD 21218 USA.
Koc Univ, Dept Math, TR-34450 Istanbul, Turkey.
RP Ratnanather, JT (reprint author), Johns Hopkins Univ, Ctr Imaging Sci, Whitaker Biomed Engn Inst, Clark 301,3400 N Charles St, Baltimore, MD 21218 USA.
EM tilak@cis.jhu.edu
RI Ratnanather, J. Tilak/A-3362-2010
OI Ratnanather, J. Tilak/0000-0002-8631-489X
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NR 54
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 95
EP 104
DI 10.1016/j.heares.2007.02.007
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900010
PM 17400411
ER
PT J
AU Zheng, Y
Baek, JH
Smith, PF
Darlington, CL
AF Zheng, Yiwen
Baek, Jean-Ha
Smith, Paul F.
Darlington, Cynthia L.
TI Cannabinoid receptor down-regulation in the ventral cochlear nucleus in
a salicylate model of tinnitus
SO HEARING RESEARCH
LA English
DT Article
DE tinnitus; cochlear nucleus; salicylate; cannabinoid receptors; rat
ID UNILATERAL VESTIBULAR DEAFFERENTATION; LOCALIZATION; ACTIVATION; SYSTEM;
BRAIN; RATS
AB Cannabinoid CB1 receptors have not been systematically investigated in the brainstem cochlear nucleus, nor have they been investigated in relation to tinnitus. Using immunohistochemistry and cell counting, we showed that a large number of neurons in the rat cochlear nucleus possess cannabinoid CB1 receptors. Following salicylate injections that induced the behavioural manifestations of tinnitus, the number of principal neurons in the ventral cochlear nucleus expressing CB1 receptors significantly decreased, while the number of CB1-positive principal neurons in the dorsal cochlear nucleus did not change significantly. These results suggest that CB I receptors in the cochlear nucleus may be important for auditory function and that a down-regulation of CB I receptors in the ventral cochlear nucleus may be related to the development of tinnitus. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Otago, Dept Pharmacol & Toxicol, Sch Med Sci, Dunedin, New Zealand.
RP Smith, PF (reprint author), Univ Otago, Dept Pharmacol & Toxicol, Sch Med Sci, POB 913, Dunedin, New Zealand.
EM paul.smith@stonebow.otago.ac.nz
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NR 23
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 105
EP 111
DI 10.1016/j.heares.2007.01.028
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900011
PM 17376618
ER
PT J
AU He, WX
Nuttall, AL
Ren, TY
AF He, Wenxuan
Nuttall, Alfred L.
Ren, Tianying
TI Two-tone distortion at different longitudinal locations on the basilar
membrane
SO HEARING RESEARCH
LA English
DT Article
DE basilar membrane; traveling wave; otoacoustic emission; distortion
products; laser interferometer
ID PRODUCT OTOACOUSTIC EMISSIONS; GUINEA-PIG; MAMMALIAN COCHLEA; INNER-EAR;
RESPONSES; PRESSURE; 2F1-F2; PROPAGATION; F2-F1; WAVE
AB When listening to two tones at frequency f(1) and f(2) (f(2) > f(1)), one can hear pitches not only at f(1) and f(2) but also at distortion frequencies f(2)-f(1),(n + 1)f(1) - nf(2), and (n + 1)f(2) - nf(1) (n = 1,2,3...). Such two-tone distortion products (DPs) also can be measured in the car canal using a sensitive microphone. These ear-generated sounds are called otoacoustic emissions (OAEs). In spite of the common applications of OAEs, the mechanisms by which these emissions travel out of the cochlea remain unclear. In a recent study, the basilar membrane (BM) vibration at 2f(1) - f(2) was measured as a function of the longitudinal location, using a scanning laser interferometer. The data indicated a forward traveling wave and no measurable backward wave. However, this study had a relatively high noise floor and high stimulus intensity. In the current study, the noise floor of the BM measurement was significantly decreased by using reflective beads on the BM, and the vibration was measured at relatively low intensities at more than one longitudinal location. The results show that the DP phase at a basal location leads the phase at an apical location. The data indicate that the emission travels along the BM from base to apex as a forward traveling wave, and no backward traveling wave was detected under the current experimental conditions. (c) 2007 Elsevier B.V. All rights reserved.
C1 Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Dept Otolaryngol & Head & Neck Surg, Portland, OR 97239 USA.
Xi An Jiao Tong Univ, Dept Otolaryngol, Hosp 1, Sch Med, Xian 710061, Shaanxi, Peoples R China.
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Xi An Jiao Tong Univ, Sch Med, Dept Physiol, Xian 710061, Peoples R China.
Shanghai Jiao Tong Univ, Dept Otolaryngol, Renji Hosp, Shanghai 200030, Peoples R China.
RP Ren, TY (reprint author), Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Dept Otolaryngol & Head & Neck Surg, Portland, OR 97239 USA.
EM rent@ohsu.edu
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NR 40
TC 21
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 112
EP 122
DI 10.1016/j.heares.2007.01.026
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900012
PM 17353104
ER
PT J
AU Chapla, ME
Nowacek, DP
Rommel, SA
Sadler, VM
AF Chapla, Marie E.
Nowacek, Douglas P.
Rommel, Sentiel A.
Sadler, Valerie M.
TI CT scans and 3D reconstructions of Florida manatee (Trichechus manatus
latirostris) heads and ear bones
SO HEARING RESEARCH
LA English
DT Article
DE manatee; computerized tomography; tissue density; ear anatomy; hearing
ID TYMPANIC MEMBRANE VIBRATIONS; MIDDLE-EAR; SOUND-VELOCITY; SPERM-WHALE;
TISSUES; SIRENIA; HEARING; MECHANICS; LIPIDS
AB The auditory anatomy of the Florida manatee (Trichechus manatus latirostris) was investigated using computerized tomography (CT), three-dimensional reconstructions, and traditional dissection of heads removed during necropsy. The densities (kg/m(3)) of the soft tissues of the head were measured directly using the displacement method and those of the soft tissues and bone were calculated from CT measurements (Hounsfield units). The manatee's fatty tissue was significantly less dense than the other soft tissues within the head (P < 0.05). The squamosal bone was significantly less dense than the other bones of the head (p < 0.05). Measurements of the ear bones (tympanic, periotic, malleus, incus, and stapes) collected during dissection revealed that the ossicular chain was overly massive for the mass of the tympanoperiotic complex. (c) 2007 Elsevier B.V. All rights reserved.
C1 Pacific Isl Fisheries Sci Ctr, Honolulu, HI 96822 USA.
Univ N Carolina, Wilmington, NC 28403 USA.
Florida State Univ, Dept Oceanog, Tallahassee, FL 32306 USA.
Florida Vet Specialists & Canc Treatment Ctr, Tampa, FL 33614 USA.
Florida Fish & Wildlife Conservat Commiss, Fish & Wildlife Res Inst, Marine Mammal Pathobiol Lab, St Petersburg, FL 33711 USA.
RP Chapla, ME (reprint author), Pacific Isl Fisheries Sci Ctr, 2570 Dole St, Honolulu, HI 96822 USA.
EM marie.chapla@noaa.gov; nowacek@ocean.fsu.edu; rommels@uncw.edu
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NR 52
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 123
EP 135
DI 10.1016/j.heares.2007.01.029
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900013
PM 17420106
ER
PT J
AU Ries, DT
AF Ries, Dennis T.
TI The influence of noise type and level upon stochastic resonance in human
audition
SO HEARING RESEARCH
LA English
DT Article
DE stochastic resonance; threshold; hearing; noise; auditory
ID MECHANOELECTRICAL TRANSDUCTION; INFORMATION; THRESHOLD; CRAYFISH;
SYSTEMS; SIGNAL
AB The present study examined the extent to which noise type and fine differentiations in noise level produced improvements in auditory threshold via the mechanism of stochastic resonance. Participants' thresholds for a sinusoidal signal (2.0 kHz) were estimated using a three interval forced choice task. These measures were obtained in quiet, in the presence of Gaussian noise, and in the presence of uniform (flat spectrum, zero-mean amplitude distribution) noise. The noises were presented at several levels from audible to inaudible (0.0 to -35.0 dB/Hz). The present results show that thresholds improved by a small, but significant, amount for noise levels just below subjects' thresholds and that these improvements are not due solely to a simple summation of power between the signal and the noise. In addition, a subset of subjects showed larger and significant threshold increases at very low noise levels (-30.0 to -35.0 dB/Hz). The outcomes suggest that either Gaussian or uniform noise produces equivalent threshold improvements, SR may already be nearly optimized in persons with normal hearing, and that the maximum benefit possible from SR occurs over a narrow range of noise levels. (c) 2007 Elsevier B.V. All rights reserved.
C1 Ohio Univ, Sch Hearing Speech & Language Sci, Grover Ctr W221, Athens, OH 45701 USA.
RP Ries, DT (reprint author), Ohio Univ, Sch Hearing Speech & Language Sci, Grover Ctr W221, Athens, OH 45701 USA.
EM ries@ohio.edu
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NR 18
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 136
EP 143
DI 10.1016/j.heares.2007.01.027
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900014
PM 17350775
ER
PT J
AU Meyer, K
Rouiller, EM
Loquet, G
AF Meyer, K.
Rouiller, E. M.
Loquet, G.
TI Direct comparison between properties of adaptation of the auditory nerve
and the ventral cochlear nucleus in response to repetitive clicks
SO HEARING RESEARCH
LA English
DT Article
DE auditory evoked potentials; brainstem; click; rat; unanaesthetized
ID SHORT-TERM ADAPTATION; BRAIN-STEM IMPLANT; BUSHY CELL AXONS; NEURAL
ADAPTATION; FIBER RESPONSES; HORSERADISH-PEROXIDASE; ACOUSTIC STIMULI;
GUINEA-PIG; LONG-TERM; CAT
AB The present study was designed to complete two previous reports [Loquet, G., Rouiller, E.M., 2002. Neural adaptation to pulsatile acoustical stimulation in the cochlear nucleus of the rat. Hear. Res. 171, 72-81; Loquet, G., Meyer, K., Rouiller, E.M., 2003. Effects of intensity of repetitive acoustic stimuli on neural adaptation in the ventral cochlear nucleus of the rat. Exp. Brain Res. 153, 436-442] on neural adaptation properties in the auditory system of the rat. Again, auditory near-field evoked potentials (ANEPs) were recorded in response to 250-ms trains of clicks from an electrode chronically implanted in the ventral cochlear nucleus (VCN). Up to now, our interest had focused on the adaptive behavior of the first one (N-1) of the two negative ANEP components. A re-examination of our data for the second negative component (N-2) was now undertaken. Results show that the adaptation time course observed for N-2 displayed the same three-stage pattern previously reported for NJ. Similarly, adaptation became more pronounced and occurred faster as stimulus intensity and/or repetition rate were increased. Based on latency data which suggest NJ and N2 to be mainly due to the activity of auditory-nerve (AN) fibers and cochlear nucleus neurons, respectively, it was concluded that neural adaptation assessed by gross-potentials was similar in the AN and VCN. This finding is meaningful in the context of our search to restore normal adaptation phenomena via electro-auditory hearing with an auditory brainstem implant on the same lines as our work in cochlear implants. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Fribourg, Dept Med, Unit Physiol, CH-1700 Fribourg, Switzerland.
RP Loquet, G (reprint author), Univ Fribourg, Dept Med, Unit Physiol, Chemin Musee 5, CH-1700 Fribourg, Switzerland.
EM gerard.loquet@unifr.ch
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NR 59
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 144
EP 155
DI 10.1016/j.heares.2007.02.002
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900015
PM 17391881
ER
PT J
AU Anderson, LA
Wallace, MN
Palmer, AR
AF Anderson, L. A.
Wallace, M. N.
Palmer, A. R.
TI Identification of subdivisions in the medial geniculate body of the
guinea pig
SO HEARING RESEARCH
LA English
DT Article
DE auditory thalamus; cytochrome oxidase; acetylcholinesterase; frequency
response area; characteristic frequency
ID CYTOCHROME-OXIDASE ACTIVITY; DORSAL COCHLEAR NUCLEUS; AUDITORY THALAMUS;
RESPONSE PROPERTIES; FUNCTIONAL-ORGANIZATION; TONOTOPIC ORGANIZATION;
SINGLE UNITS; PARVALBUMIN-IMMUNOREACTIVITY; INFERIOR COLLICULUS; VENTRAL
DIVISION
AB The accurate and reliable identification of subdivisions within the auditory thalamus is important for future studies of this nucleus. However, in the guinea pig, there has been no agreement on the number or nomenclature of subdivisions within the main nucleus of the auditory thalamus, the medial geniculate body (MGB). Thus, we assessed three staining methods in the guinea pig MGB and concluded that cytochrome oxidase (CYO) histochemistry provides a clear and reliable method for defining MGB subdivisions. By combining CYO with acetylcbolinesterase staining and extensive physiological mapping we defined five separate divisions, all of which respond to auditory stimuli. Coronal sections stained for CYO revealed a moderate to darkly-stained oval core. This area (the ventral MGB) contained a high proportion (61%) of V-shaped tuning curves and a tonotopic organisation of characteristic frequencies. It was surrounded by four smaller areas that contained darkly stained somata but had a paler neuropil. These areas, the dorsolateral and suprageniculate (which together form the dorsal MGB), the medial MGB and the shell MGB, did not have any discernable tonotopic frequency gradient and contained a smaller proportion of V-shaped tuning curves. This suggests that CYO permits the identification of core and belt areas within the guinea pig MGB. (c) 2007 Elsevier B.V. All rights reserved.
C1 MRC, Inst Hearing Res, Nottingham NG7 2RD, England.
RP Anderson, LA (reprint author), Ctr Auditory Res, 332 Grays Inn Rd, London WC1X 8EE, England.
EM lucy.anderson@ucl.ac.uk
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NR 56
TC 28
Z9 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 156
EP 167
DI 10.1016/j.heares.2007.02.005
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900016
PM 17399924
ER
PT J
AU Brozoski, TJ
Ciobanu, L
Bauer, CA
AF Brozoski, Thomas J.
Ciobanu, Luisa
Bauer, Carol A.
TI Central neural activity in rats with tinnitus evaluated with
manganese-enhanced magnetic resonance imaging (MEMRI)
SO HEARING RESEARCH
LA English
DT Article
DE tinnitus; CNS activity; MEMRI; animal model; plasticity
ID DORSAL COCHLEAR NUCLEUS; INFERIOR COLLICULUS; AUDITORY-CORTEX; INDUCE
TINNITUS; INTENSE SOUND; SINGLE UNITS; ANIMAL-MODEL; GUINEA-PIG; CAT;
MANIPULATIONS
AB The pathophysiology of tinnitus, the perception of sound in the absence of acoustic stimulation, is largely unknown, although several lines of research implicate long-term neuroplastic loss of inhibition. The evidence to date suggests that the neuroplastic alterations are likely to be found in multiple brain structures. The present study used manganese-enhanced magnetic resonance imaging (MEMRI) to assess the pattern of neural activity in the central auditory pathway of rats with psychophysical evidence of chronic acoustic-exposure-induced tinnitus. Manganese, an activity-dependent paramagnetic contrast agent, accumulates in active neurons through voltage-gated calcium channels, primarily at synapses, and serves as both a structural and functional indicator. Comparison images were obtained from normal subjects exposed to external tinnitus-like sound, and from tinnitus subjects treated with vigabatrin, a GABA agonist shown to eliminate the psychophysical evidence of tinnitus in rats. MEMRI indicated: (1) In rats with evidence of tinnitus, activity was generally elevated in the auditory brainstem, with significant elevation in the cerebellar parallocculus, the posterior ventral cochlear nucleus, and the inferior colliculus; in general forebrain structures showed decreased activity, although MEMRI may be a less sensitive indicator of forebrain activity than brainstem activity; (2) in normal rats exposed to a tinnitus-like sound, a similar pattern of elevated brainstem activity and decreased forebrain activity was evident, with the notable exception of the paraflocculus, where artificial tinnitus had no effect and (3) vigabatrin, decreased brainstem activity to control levels, in rats with prior evidence of tinnitus, and decreased forebrain activity to below control levels. It was concluded that chronic tinnitus in rats is associated with focal activity elevation in the auditory brainstem and increased activity in the paraflocculus that may be unique to tinnitus. (c) 2007 Published by Elsevier B.V.
C1 So Illinois Univ, SOM, Div Otolaryngol, Springfield, IL 62794 USA.
Univ Illinois, Beckman Inst Adv Sci & Technol, Biomed Imaging Ctr, Urbana, IL 61801 USA.
RP Brozoski, TJ (reprint author), So Illinois Univ, SOM, Div Otolaryngol, 801 N Rutledge St,Rm 3205,POB 19629, Springfield, IL 62794 USA.
EM tbrozoski@siumed.edu
RI Ciobanu, Luisa/E-7331-2014
OI Ciobanu, Luisa/0000-0001-6932-6859
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NR 42
TC 59
Z9 64
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 168
EP 179
DI 10.1016/j.heares.2007.02.003
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900017
PM 17382501
ER
PT J
AU Rejali, D
Lee, VA
Abrashkin, KA
Humayun, N
Swiderski, DL
Raphael, Y
AF Rejali, Darius
Lee, Valerie A.
Abrashkin, Karen A.
Humayun, Nousheen
Swiderski, Donald L.
Raphael, Yehoash
TI Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion
neurons
SO HEARING RESEARCH
LA English
DT Article
DE guinea pig; adenovirus vector; nerve protection; ex vivo gene therapy;
BDNF
ID HAIR CELL LOSS; NEUROTROPHIC FACTOR; AUDITORY NEURONS; INNER-EAR;
IN-VIVO; DEGENERATION; SURVIVAL; STIMULATION; CULTURE
AB Spiral ganglion neurons often degenerate in the deaf ear, compromising the function of cochlear implants. Cochlear implant function can be improved by good preservation of the spiral ganglion neurons, which are the target of electrical stimulation by the implant. Brain derived neurotrophic factor (BDNF) has previously been shown to enhance spiral ganglion survival in experimentally deafened ears. Providing enhanced levels of BDNF in human ears may be accomplished by one of several different methods. The goal of these experiments was to test a modified design of the cochlear implant electrode that includes a coating of fibroblast cells transduced by a viral vector with a BDNF gene insert. To accomplish this type of ex vivo gene transfer, we transduced guinea pig fibroblasts with an adenovirus with a BDNF gene cassette insert, and determined that these cells secreted BDNF. We then attached BDNF-secreting cells to the cochlear implant electrode via an agarose gel, and implanted the electrode in the scala tympani. We determined that the BDNF expressing electrodes were able to preserve significantly more spiral ganglion neurons in the basal turns of the cochlea after 48 days of implantation when compared to control electrodes. This protective effect decreased in the higher cochlear turns. The data demonstrate the feasibility of combining cochlear implant therapy with ex vivo gene transfer for enhancing spiral ganglion neuron survival. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Sch Med, Ann Arbor, MI 48109 USA.
Univ Hosp Warwickshire & Coventry NHS Trust, Coventry CV2 2DX, W Midlands, England.
Univ Texas, Hlth Sci Ctr, San Antonio, TX USA.
RP Raphael, Y (reprint author), Univ Michigan, Kresge Hearing Res Inst, Sch Med, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM Yoash@umich.edu
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NR 31
TC 57
Z9 62
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 180
EP 187
DI 10.1016/j.heares.2007.02.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900018
PM 17416474
ER
PT J
AU Lutkenhoner, B
Klein, JS
AF Lutkenhoener, Bernd
Klein, Jan-Stefan
TI Auditory evoked field at threshold
SO HEARING RESEARCH
LA English
DT Article
DE intensity coding; temporal integration; auditory cortex; auditory evoked
field; magnetoencephalography; multiple-look model
ID NERVE 1ST-SPIKE LATENCY; TEMPORAL INTEGRATION; MAGNETIC-FIELDS; ABSOLUTE
THRESHOLD; COMPUTER-MODEL; HUMAN-BRAIN; GUINEA-PIG; INTENSITY; CORTEX;
FIBERS
AB Auditory evoked responses are widely used for estimating electrophysiological thresholds, but the relationships to psychophysical thresholds are not necessarily straightforward. Among the aspects that are not well understood is the near-threshold intensity dependence of the evoked response. Here, we investigated wave N100m of the auditory evoked field. The stimulus was a 1-kHz tone with an effective duration of about 110 ms. Up to 10 dB above the psychophysical threshold, the level was varied in steps of 2 dB; further measurements were done at 15, 20, 30, and 40 dB SL. Lower levels were presented with higher probability, to partially compensate for the expected signal-to-noise ratio reduction with decreasing level. The latency of the N100m could be characterized as a transmission delay and an integration time. The level dependence of the latter was consistent with the assumption of an almost perfectly operating sound-pressure integrator. The N 100m amplitude increased roughly linearly with the level in dB (thus, as a logarithmic function of intensity), showing signs of saturation at higher levels. (c) 2007 Elsevier B.V. All rights reserved.
C1 Munster Univ Hosp, ENT Clin, Sect Expt Audiol, Munster, Germany.
RP Lutkenhoner, B (reprint author), Munster Univ Hosp, ENT Clin, Sect Expt Audiol, Munster, Germany.
EM Lutkenh@uni-muenster.de
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NR 53
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 188
EP 200
DI 10.1016/j.heares.2007.02.011
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900019
PM 17434696
ER
PT J
AU Lee, JH
Heo, JH
Kim, CH
Chang, SO
Kim, CS
Oh, SH
AF Lee, Jun Ho
Heo, Jeong-Hwa
Kim, Chang-Hee
Chang, Sun O.
Kim, Chong-Sun
Oh, Seung-Ha
TI Changes in P2Y(4) receptor expression in rat cochlear outer sulcus cells
during development
SO HEARING RESEARCH
LA English
DT Article
DE voltage-sensitive vibrating probe; purinergic receptor; outer sulcus
cell; inner ear; endolymph
ID 5'-TRIPHOSPHATE-GATED ION-CHANNEL; STRIAL MARGINAL CELLS; INNER-EAR;
EPITHELIAL-CELLS; P2X RECEPTORS; K+ SECRETION; GUINEA-PIG; TRIPHOSPHATE
DIPHOSPHOHYDROLASE-1; ADENOSINE 5'-TRIPHOSPHATE; PHARMACOLOGICAL
PROFILES
AB Extracellular adenosine triphosphate (ATP) released from cellular sources plays an important role in variety of the cochlear physiologic processes. The primary purinergic receptor subtype in the cochlea is the P2X(2) receptor, which is a subtype of P2X receptor. This receptor appears to mediate a protective decrease in the electrical driving force in response to acoustic overstimulation. Outer sulcus cells (OSCs) in the cochlear lateral wall appear to maintain an adequate K+ concentration in the cochlear endolymph in response to varying intensities of auditory stimulation. However, little is known about developing OSCs. The purpose of this study was to investigate subtypes of purinergic receptors in developing rat OSCs using a voltage-sensitive vibrating probe. Results showed that only two P2 receptors (P2Y(4) and P2X(2)) contributed to the regulation of short circuit currents in neonatal OSCs'. ATP increased cation absorption via apical nonselective cation channels after activating P2Y4 receptors in early neonatal OSCs. P2Y4 expression rapidly declined postnatally and reached near adult levels on postnatal day 14. P2X(2) was co-expressed with P2Y4 in early neonatal OSCs. Temporal changes in P2Y4 during OSC development might be involved in the establishment of the endolymphatic ion composition needed for normal auditory transduction and/or specific cellular differentiation. (c) 2007 Elsevier B.V. All rights reserved.
C1 Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Otolaryngol Head & Neck Surg, Seoul 110744, South Korea.
RP Oh, SH (reprint author), Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Otolaryngol Head & Neck Surg, 28 Yeongon Dong, Seoul 110744, South Korea.
EM junlee@snu.ac.kr; amaranthh@paran.com; tatsuya@freechal.com;
suno@snu.ac.kr; chongkim@plaza.snu.ac.kr; shaoh@snu.ac.kr
RI Oh, Seung Ha/J-5540-2012
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NR 61
TC 8
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 201
EP 211
DI 10.1016/j.heares.2007.02.008
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900020
PM 17433586
ER
PT J
AU Felix, RA
Portfors, CV
AF Felix, Richard A., II
Portfors, Christine V.
TI Excitatory, inhibitory and facilitatory frequency response areas in the
inferior colliculus of hearing impaired mice
SO HEARING RESEARCH
LA English
DT Article
DE inferior colliculus; spectral integration; presbycusis; mouse; hearing
ID COMBINATION-SENSITIVE NEURONS; BAT PTERONOTUS-PARNELLII; PRIMARY
AUDITORY-CORTEX; MOUSTACHED BAT; SPECTRAL INTEGRATION; TONOTOPIC
ORGANIZATION; COCHLEAR NUCLEUS; COMMUNICATION CALLS; SPEECH RECOGNITION;
CORTICAL-NEURONS
AB Individuals with age-related hearing loss often have difficulty understanding complex sounds such as basic speech. The C57BL/6 mouse suffers from progressive sensorineural hearing loss and thus is an effective tool for dissecting the neural mechanisms underlying changes in complex sound processing observed in humans. Neural mechanisms important for processing complex sounds include multiple tuning and combination sensitivity, and these responses are common in the inferior colliculus (IC) of normal hearing mice. We examined neural responses in the IC of C57B1/6 mice to single and combinations of tones to examine the extent of spectral integration in the IC after age-related high frequency hearing loss. Ten percent of the neurons were tuned to multiple frequency bands and an additional 10% displayed non-linear facilitation to the combination of two different tones (combination sensitivity). No combination-sensitive inhibition was observed. By comparing these findings to spectral integration properties in the IC of normal hearing CBA/CaJ mice, we suggest that high frequency hearing loss affects some of the neural mechanisms in the IC that underlie the processing of complex sounds. The loss of spectral integration properties in the IC during aging likely impairs the central auditory system's ability to process complex sounds such as speech. (c) 2007 Elsevier B.V. All rights reserved.
C1 Washington State Univ, Sch Biol Sci, Vancouver, WA 98686 USA.
RP Portfors, CV (reprint author), Washington State Univ, Sch Biol Sci, 14204 NE Salmon Creek Ave, Vancouver, WA 98686 USA.
EM Portfors@vancouver.wsu.edu
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NR 74
TC 21
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2007
VL 228
IS 1-2
BP 212
EP 229
DI 10.1016/j.heares.2007.02.009
PG 18
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 174QP
UT WOS:000246957900021
PM 17412539
ER
PT J
AU Kros, CJ
AF Kros, Corne J.
TI How to build an inner hair cell: Challenges for regeneration
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Inner Ear Biology Workshop Symposium on Terminal Differentiation - A
Challenge in regeneration
CY SEP 17, 2005
CL Tubingen, GERMANY
DE inner hair cell; development; regeneration; ion channel; exocytosis
ID COCHLEAR NUCLEUS NEURONS; NICOTINIC CHOLINERGIC-RECEPTOR; GUINEA-PIG
COCHLEA; POTASSIUM CURRENTS; MOUSE COCHLEA; DEVELOPMENTAL EXPRESSION;
POSTNATAL-DEVELOPMENT; CA(V)1.3 CHANNELS; SUPPORTING CELLS; IONIC
CURRENTS
AB During their development inner hair cells (IHCs), the primary sensory receptors in the mammalian cochlea, undergo a meticulously orchestrated series of changes in the expression of ion channels and in their presynaptic function. This review considers what we currently know about these changes in IHCs of mice and rats, which start hearing 10-12 days after birth. Just after terminal mitosis the IHCs are electrically quiescent and functionally isolated, expressing only small and slow outward K+ currents in their basolateral membranes. By the first postnatal week the cells have acquired inward Ca2+ and Na+ currents that enable them to fire spontaneous action potentials at a time when the cochlea can not yet be stimulated by sound. These action potentials may be essential for normal development and survival of the IHCs themselves and of the afferent nerve fibres that synapse with them. At the onset of hearing the transition to a functionally mature sensory receptor comes about by the expression of a large and fast BK current, I-K,(f), a KCNQ4 current, I-K,I-n,I- and by changes in the exocytotic machinery. Some implications of this complex developmental programme for the ideal of hair-cell regeneration in the mature mammalian cochlea are discussed. (C) 2007 Elsevier B.V. All rights reserved.
C1 Univ Sussex, Sch Life Sci, Brighton BN1 9QG, E Sussex, England.
RP Kros, CJ (reprint author), Univ Sussex, Sch Life Sci, Brighton BN1 9QG, E Sussex, England.
EM c.j.kros@sussex.ac.uk
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NR 58
TC 12
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2007
VL 227
IS 1-2
SI SI
BP 3
EP 10
DI 10.1016/j.heares.2006.12.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 169ZP
UT WOS:000246630900002
PM 17258412
ER
PT J
AU Warchol, ME
AF Warchol, Mark E.
TI Characterization of supporting cell phenotype in the avian inner ear:
Implications for sensory regeneration
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Inner Ear Biology Workshop Symposium on Terminal Differentiation - A
Challenge in regeneration
CY SEP 17, 2005
CL Tubingen, GERMANY
DE utricle; vestibular; development; tectorin; cadherin; cProx1; PAX2;
GATA3
ID MOUSE VESTIBULAR EPITHELIA; SERUM-FREE CULTURE; HAIR-CELLS; E-CADHERIN;
BETA-CATENIN; ADHESION MOLECULES; TECTORIAL MEMBRANE; PROGENITOR CELLS;
DEVELOPING ORGAN; GAP-JUNCTIONS
AB The avian inner ear possesses a remarkable capacity for the regeneration of sensory receptors after acoustic trauma or ototoxicity. Most replacement hair cells are created by renewed cell division within the sensory epithelium, although some new hair cells may also arise through nonmitotic mechanisms. Current data indicate that epithelial supporting cells play an essential role in regeneration, by serving as progenitor cells. In order to become progenitors, however, supporting cells may need to undergo partial dedifferentiation. In this review, I describe molecules that are expressed by supporting cells in the avian ear. Although a number of these molecules are likely to be critical to the maintenance of the supporting cell phenotype, we presently know very little about phenotypic changes in supporting cells during the early phase of regeneration. (C) 2006 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA.
RP Warchol, ME (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, 660 S Euclid Ave,Box 8115, St Louis, MO 63110 USA.
EM warcholm@ent.wustl.edu
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NR 69
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2007
VL 227
IS 1-2
SI SI
BP 11
EP 18
DI 10.1016/j.heares.2006.08.014
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 169ZP
UT WOS:000246630900003
PM 17081713
ER
PT J
AU Ruel, J
Wang, J
Rebillard, G
Eybalin, M
Lloyd, R
Pujol, R
Puel, JL
AF Ruel, Jerome
Wang, Jing
Rebillard, Guy
Eybalin, Michel
Lloyd, Ruth
Pujol, Remy
Puel, Jean-Luc
TI Physiology, pharmacology and plasticity at the inner hair cell synaptic
complex
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Inner Ear Biology Workshop Symposium on Terminal Differentiation - A
Challenge in regeneration
CY SEP 17, 2005
CL Tubingen, GERMANY
DE ribbon synapses; glutamate; AMPA; NMDA; lateral efferent; dopamine;
cochlea
ID GUINEA-PIG COCHLEA; GLUTAMATE-ASPARTATE TRANSPORTER; SPIRAL GANGLION
NEURONS; AUDITORY-NERVE ACTIVITY; AMINO-ACID TRANSPORTER; HIGH-AFFINITY;
RAT COCHLEA; KAINIC ACID; EXCITOTOXIC INJURY; AFFERENT SYNAPSES
AB This report summarizes recent neuropharmacological data at the IHC afferent/efferent synaptic complex: the type of Glu receptors and transporter involved and the modulation of this fast synaptic transmission by the lateral efferents. Neuropharmacological data were obtained by coupling the recording of cochlear potentials and single unit of the auditory nerve with intra-cochlear applications of drugs (multi-barrel pipette). We also describe the IHC afferent/efferent functioning in pathological conditions. After acoustic trauma or ischemia, acute disruption of IHC-auditory dendrite synapses are seen. However, a re-growth of the nerve fibres and a re-afferentation of the IHC were completely done 5 days after injury. During this synaptic repair, multiple presynaptic bodies were commonly found, either linked to the membrane or "floating" in ectopic positions. In the meantime, the lateral efferents directly contact the IHCs. The demonstration that NMDA receptors blockade delayed the re-growth of neurites suggests a neurotrophic role of NMDA receptors in pathological conditions. (C) 2006 Elsevier B.V. All rights reserved.
C1 Hop St Eloi, INSERM U583, INM, F-34091 Montpellier 5, France.
Univ Montpellier 1, F-34006 Montpellier, France.
RP Puel, JL (reprint author), Hop St Eloi, INSERM U583, INM, 80 Ave Augustin Fliche,BP 74103, F-34091 Montpellier 5, France.
EM puel@montp.inserm.fr
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NR 73
TC 49
Z9 51
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2007
VL 227
IS 1-2
SI SI
BP 19
EP 27
DI 10.1016/j.heares.2006.08.017
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 169ZP
UT WOS:000246630900004
PM 17079104
ER
PT J
AU Tsonis, PA
AF Tsonis, Panagiotis A.
TI Regeneration via transdifferentiation: The lens and hair cells
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Inner Ear Biology Workshop Symposium on Terminal Differentiation - A
Challenge in regeneration
CY SEP 17, 2005
CL Tubingen, GERMANY
DE regeneration; transdifferentiation; lens; hair cells
ID SENSORY EPITHELIA; HEARING; EXPRESSION; INDUCTION; BALANCE
AB Tissue repair and regeneration is mediated by mainly two strategies, the one employing the services of reserve cells and the other via transdifferentiation of already differentiated somatic cells. In this mini-review some issues of transdifferentiation will be presented, especially as they pertain to regeneration and induction of lens and hair cells in several animal models. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Dayton, Dept Biol, Dayton, OH 45469 USA.
Univ Dayton, Ctr Tissue Regenerat & Engn, Dayton, OH 45469 USA.
RP Tsonis, PA (reprint author), Univ Dayton, Dept Biol, 300 Coll Pk, Dayton, OH 45469 USA.
EM panagiotis.tsonis@notes.udayton.edu
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NR 21
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2007
VL 227
IS 1-2
SI SI
BP 28
EP 31
DI 10.1016/j.heares.2006.06.011
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 169ZP
UT WOS:000246630900005
PM 16942849
ER
PT J
AU Holley, MC
Kneebone, A
Milo, M
AF Holley, M. C.
Kneebone, A.
Milo, M.
TI Information for gene networks in inner ear development: A study centered
on the transcription factor gata2
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Inner Ear Biology Workshop Symposium on Terminal Differentiation - A
Challenge in regeneration
CY SEP 17, 2005
CL Tubingen, GERMANY
DE cell lines; oligonucleotide arrays; gMOS; cochlea; gene networks; gata2
ID CELL-LINES; OLIGONUCLEOTIDE ARRAYS; EXPRESSION; DIFFERENTIATION; MODEL;
PRECURSORS; GENOMICS; INHIBIT; MUSCLE; MOUSE
AB The search for molecular mechanisms to stimulate sensory regeneration in the mammalian inner ear is commonly based upon developmental studies. This has revealed many genes that regulate the differentiation of sensory cells. A major challenge is to place these genes into the context of functional networks that describe developmental processes more fully and increase the chances of identifying useful therapeutic targets. We used a novel approach to identify genes that are functionally related to the transcription factor gata2. Temporal profiles of gene expression were derived from three conditionally immortal cell lines and clustered to those of gata2 by applying the gamma model for oligonucleotide signals, a statistical method that allows quantitative analysis of oligonucleotide array data. We derived an objective list of 28 genes that clustered with gata2 in all three cell lines. A number of these genes have known functional links with gata2. Genes encoding CCAAT/enhancer binding proteins (C/EBP) and signal transducer and activation of transcription 3 (Stat3) are especially interesting as they are known to bind gata proteins directly. The results provide strong evidence that our experimental approach can reveal functional relationships between genes that regulate fundamental processes in the differentiation of sensory cells in the inner ear. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England.
RP Holley, MC (reprint author), Univ Sheffield, Dept Biomed Sci, Addison Bldg,Western Bank, Sheffield S10 2TN, S Yorkshire, England.
EM m.c.holley@shefac.uk; a.kneebone@sheffield.ac.uk; m.milo@sheffield.ac.uk
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NR 35
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2007
VL 227
IS 1-2
SI SI
BP 32
EP 40
DI 10.1016/j.heares.2006.04.006
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 169ZP
UT WOS:000246630900006
PM 16797894
ER
PT J
AU Batts, SA
Raphael, Y
AF Batts, Shelley A.
Raphael, Yehoash
TI Transdifferentiation and its applicability for inner ear therapy
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Inner Ear Biology Workshop Symposium on Terminal Differentiation - A
Challenge in regeneration
CY SEP 17, 2005
CL Tubingen, GERMANY
DE transdifferentiation; regeneration; conversion; cochlea; stem cell; hair
cell; supporting cell; deafness; gene therapy
ID HAIR CELL REGENERATION; AVIAN AUDITORY EPITHELIUM; PLURIPOTENT
STEM-CELLS; ACOUSTIC TRAUMA; SUPPORTING CELLS; PROGENITOR CELLS;
GENE-EXPRESSION; CHICK COCHLEA; GUINEA-PIGS; IN-VIVO
AB During normal development, cells divide, then differentiate to adopt their individual form and function in an organism. Under most circumstances, mature cells cannot transdifferentiate, changing their fate to adopt a different form and function. Because differentiated cells cannot usually divide, the repair of injuries as well as regeneration largely depends on the activation of stem cell reserves. The mature cochlea is an exception among epithelial cell layers in that it lacks stem cells. Consequently, the sensory hair cells that receive sound information cannot be replaced, and their loss results in permanent hearing impairment. The lack of a spontaneous cell replacement mechanism in the organ of Corti, the mammalian auditory sensory epithelium, has led researchers to investigate circumstances in which transdifferentiation does occur. The hope is that this information can be used to design therapies to replace lost hair cells and restore impaired hearing in humans. (C) 2006 Elsevier B.V. All rights reserved.
C1 Kresge Hearing Res Inst, Dept Otolaryngol, Ann Arbor, MI 48109 USA.
RP Raphael, Y (reprint author), Kresge Hearing Res Inst, Dept Otolaryngol, MSRB-3,Room 9301, Ann Arbor, MI 48109 USA.
EM Yoash@umich.edu
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NR 59
TC 8
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2007
VL 227
IS 1-2
SI SI
BP 41
EP 47
DI 10.1016/j.heares.2006.08.015
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 169ZP
UT WOS:000246630900007
PM 17070000
ER
PT J
AU Martinez-Monedero, R
Oshima, K
Heller, S
Edge, ASB
AF Martinez-Monedero, Rodrigo
Oshima, Kazuo
Heller, Stefan
Edge, Albert S. B.
TI The potential role of endogenous stem cells in regeneration of the inner
ear
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Inner Ear Biology Workshop Symposium on Terminal Differentiation - A
Challenge in regeneration
CY SEP 17, 2005
CL Tubingen, GERMANY
DE stem cells; hair cells; spiral ganglion; regeneration
ID NEURAL PROGENITOR CELLS; PANCREATIC BETA-CELLS; HAIR-CELLS; COCHLEAR
NERVE; AUDITORY NEUROPATHY; SUPPORTING CELLS; SPIRAL GANGLION; ACOUSTIC
TRAUMA; HEARING-LOSS; DEGENERATION
AB Stem cells in various mammalian organs retain the capacity to renew themselves and may be able to restore damaged tissue. Their existence has been proven by genetic tracer studies that demonstrate their differentiation into multiple tissue types and by their ability to self-renew through proliferation. Stem cells from the adult nervous system proliferate to form clonal floating colonies called spheres in vitro, and recent studies have demonstrated sphere formation by cells in the cochlea in addition to the vestibular system and the auditory ganglia, indicating that these tissues contain cells with stem cell properties. The presence of stem cells in the inner ear raises the hope of regeneration of mammalian inner ear cells but is difficult to correlate with the lack of spontaneous regeneration seen in the inner ear after tissue damage. Loss of stem cells postnatally in the cochlea may correlate with the loss of regenerative capacity and may limit our ability to stimulate regeneration. Retention of sphere forming ability in adult vestibular tissues suggests that the limited capacity for repair may be attributed to the continued presence of progenitor cells. Future strategies for regeneration must consider the distribution of endogenous stem cells in the inner ear and whether the tissue retains cells with the capacity for regeneration. (C) 2007 Elsevier B.V. All rights reserved.
C1 Massachusetts Eye & Ear Infirm, Tillotson Unit Cell Biol, Eaton Peabody Lab, Boston, MA 02114 USA.
Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
Harvard Univ, Div Hlth Sci & Technol, Program Speech & Hearing Biosci, Cambridge, MA 02139 USA.
MIT, Cambridge, MA 02139 USA.
Stanford Univ, Sch Med, Dept Otolaryngol HNS & Mol Cellular Physiol, Stanford, CA 94305 USA.
RP Edge, ASB (reprint author), Massachusetts Eye & Ear Infirm, Tillotson Unit Cell Biol, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM albert_edge@meei.harvard.edu
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NR 42
TC 20
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2007
VL 227
IS 1-2
SI SI
BP 48
EP 52
DI 10.1016/j.heares.2006.12.015
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 169ZP
UT WOS:000246630900008
PM 17321086
ER
PT J
AU Praetorius, M
Baker, K
Brough, DE
Plinkert, P
Staecker, H
AF Praetorius, Mark
Baker, Kim
Brough, Douglas E.
Plinkert, Peter
Staecker, Hinrich
TI Pharmacodynamics of adenovector distribution within the inner ear
tissues of the mouse
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Inner Ear Biology Workshop Symposium on Terminal Differentiation - A
Challenge in regeneration
CY SEP 17, 2005
CL Tubingen, GERMANY
DE gene therapy; cochlea; vestibular; adenovirus; perilymph; drug delivery;
inner ear
ID MEDIATED GENE-TRANSFER; CELLS IN-VIVO; GUINEA-PIG; ADENOASSOCIATED
VIRUS; TRANSGENE EXPRESSION; HAIR-CELLS; VECTOR; ADENOVIRUS; COCHLEA;
THERAPY
AB Recent studies have demonstrated that delivery of genes to the inner ear can achieve a variety of effects ranging from support of auditory neuron survival to protection and restoration of hair cells, demonstrating the utility of vector based gene delivery. Translation of these findings to useful experimental systems or even clinical applications requires a detailed understanding of the pharmacokinetics of gene delivery in the inner ear. Ideal gene delivery systems will employ a well tolerated vector which efficiently transduces the appropriate target cells within a tissue, but spare non-target structures. Adenovectors based on serotype 5 (Ad 5) are commonly used vectors, are easy to construct and have a long track record of efficacious gene transfer in the inner ear. In this study we demonstrate that distribution of Ads vector occurs in a basal to apical gradient with rapid distribution of vector to the vestibule after delivery via a round window cochleostomy. Transduction of the vector and expression of the delivered transgene occurs by 10 min post vector delivery. At 24 h post delivery only 16% of vector that was initially detectable within the inner ear by quantitative PCR remained. Perilymph sampling was used to determine that vector concentrations in perilymph peaked at 30 min post delivery and then declined rapidly. Understanding these basic distribution patterns and parameters for delivery are important for the design of gene delivery vectors and vital for modeling dose responses to achieve safe efficacious delivery of a therapeutic agent. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, Kansas City, KS 66160 USA.
Univ Heidelberg, Med Ctr, Dept Otolaryngol, D-6900 Heidelberg, Germany.
Univ Maryland, Med Ctr, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21201 USA.
GenVec Inc, Gaithersburg, MD USA.
RP Staecker, H (reprint author), Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, 3901 Rainbow Blvd,MS 3010, Kansas City, KS 66160 USA.
EM hstaecker@kumc.edu
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NR 20
TC 10
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2007
VL 227
IS 1-2
SI SI
BP 53
EP 58
DI 10.1016/j.heares.2006.07.002
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 169ZP
UT WOS:000246630900009
PM 17081711
ER
PT J
AU Takeda-Nakazawa, H
Harada, N
Shen, J
Kubo, N
Zenner, HP
Yamashita, T
AF Takeda-Nakazawa, Hiroko
Harada, Narinobu
Shen, Jing
Kubo, Nobuo
Zenner, Hans-Peter
Yamashita, Toshio
TI Hyposmotic stimulation-induced nitric oxide production in outer hair
cells of the guinea pig cochlea
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Inner Ear Biology Workshop Symposium on Terminal Differentiation - A
Challenge in regeneration
CY SEP 17, 2005
CL Tubingen, GERMANY
DE cochlea; DAF-2 DA; hypotonic stimulation; nitric oxide; outer hair cell;
transient receptor potential vanilloid 4
ID INDUCED CA2+ MOBILIZATION; RABBIT PROXIMAL TUBULE; MICE LACKING TRPV4;
ENDOTHELIAL-CELLS; INNER-EAR; INTRACELLULAR CALCIUM; K+ CHANNELS;
ACTIVATION; SYNTHASE; ATP
AB Nitric oxide (NO) production during hyposmotic stimulation in outer hair cells (OHCs) of the guinea pig cochlea was investigated using the NO sensitive dye DAF-2. Simultaneous measurement of the cell length and NO production showed rapid hyposmotic-induced cell swelling to precede NO production in OHCs. Hyposmotic stimulation failed to induce NO production in the Ca2+-free solution. L-N-G-nitroarginine methyl ester (L-NAME), a non-specific NO synthase inhibitor and gadolinium, a stretch-activated channel blocker inhibited the hyposmotic stimulation-induced NO production whereas suramin, a P2 receptor antagonist did not. S-nitroso-N-acetylpenicillamine (SNAP), a NO donor inhibited the hyposmotic stimulation-induced increase in the intracellular Ca2+ concentrations ([Ca 2+](i)) while L-NAME enhanced it. 1H-[1,2,4]oxadiazole[4,3a]quinoxalin-1-one, an inhibitor of guanylate cyclase and KT5823, an inhibitor of cGMP-dependent protein kinase (PKG) mimicked effects of L-NAME on the Ca2+ response. Transient receptor potential vanilloid 4 (TRPV4), an osmo- and mechanosensitive channel was expressed in the OHCs by means of immunohistochemistry. 4 alpha-phorbol 12,13-didecanoate, a TRPV4 synthetic activator, induced NO production in OHCs. These results suggest that hyposmotic stimulation can induce NO production by the [Ca2+](i) increase, which is presumably mediated by the activation of TRPV4 in OHCs. NO conversely inhibits the Ca2+ response via the NO-cGMP-PKG pathway by a feedback mechanism. (C) 2006 Elsevier B.V. All rights reserved.
C1 Kansai Med Univ, Hearing Res Lab, Dept Otolaryngol, Moriguchi, Osaka 5708507, Japan.
Harada Ear Inst, Higashiosaka, Osaka 5770816, Japan.
Univ Tubingen, Dept Otolaryngol, D-72076 Tubingen, Germany.
RP Harada, N (reprint author), Kansai Med Univ, Hearing Res Lab, Dept Otolaryngol, Fumizonocho 10-15, Moriguchi, Osaka 5708507, Japan.
EM hrd@wood.odn.ne.jp
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NR 69
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2007
VL 227
IS 1-2
SI SI
BP 59
EP 70
DI 10.1016/j.heares.2006.09.007
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 169ZP
UT WOS:000246630900010
PM 17092670
ER
PT J
AU Price, GR
AF Price, G. Richard
TI Predicting mechanical damage to the organ of Corti
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE auditory hazard; impulse noise; AHAAH; hazard model; auditory damage;
pharmacological intervention
ID IMPULSE NOISE; HEARING-LOSS; CORDLESS TELEPHONES; HAZARD; EAR; MODEL;
DISPLACEMENT; FREQUENCY; INTENSITY; EXPOSURE
AB The potential for pharmacological intervention to ameliorate the effects of exposure to intense auditory stimulation is a truly exciting possibility. In theory, the effects of intense stimulation could be primarily a function of mechanical stress and its sequelae or possibly metabolic exhaustion. Conceivably, specific pharmacological therapies might be more effective following different types of insult, depending on the loss mechanism(s) involved. The Auditory Hazard Assessment Algorithm for the Human (AHAAH), a first-principles mathematical model for the ear, has been developed specifically to predict hazard at high intensities based on basilar membrane displacement. Validation studies have proven it to be accurate in rating risk for the human ear. AHAAH is available for download on the Internet. In the present context it was used to propose analytic stimuli that would help to elucidate the loss mechanisms and also to identify exposures for the clinician that should be considered as sufficiently hazardous to warrant potential pharmacological intervention either before or after the exposure. (C) 2006 Elsevier B.V. All rights reserved.
C1 AH Anal, Charlestown, MD 21914 USA.
RP Price, GR (reprint author), AH Anal, POB 368,125 Conestoga St, Charlestown, MD 21914 USA.
EM AHAnalysis@comcast.net
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NR 49
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 5
EP 13
DI 10.1016/j.heares.2006.08.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000002
PM 16978813
ER
PT J
AU Chen, GD
Zhao, HB
AF Chen, Guang-Di
Zhao, Hong-Bo
TI Effects of intense noise exposure on the outer hair cell plasma membrane
fluidity
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE outer hair cell; plasma membrane lateral diffusion; noise-induced
hearing loss; FRAP; cochlear amplifier
ID AUDITORY SENSORY CELLS; INDUCED HEARING-LOSS; LIPID-PEROXIDATION;
NITRIC-OXIDE; GUINEA-PIG; FLUORESCENCE RECOVERY; MICROSOMAL MEMBRANE;
COCHLEAR AMPLIFIER; RADICAL GENERATION; OXIDATIVE DAMAGE
AB Outer hair cells (OHCs) play an important role in cochlear amplification via their length changes (electromotility). A noise-induced cochlear amplification loss leading to a permanent threshold shift (PTS) was observed without a significant hair cell loss in rats [Chen, G.D., Liu, Y., 2005. Mechanisms of noise-induced hearing loss potentiation by hypoxia. Hear. Res. 200, 1-9.]. Since motor proteins are inserted in the OHC lateral membrane, any change in the OHC plasma membrane may result in a loss of OHC electromotility, leading to a loss of cochlear amplification. In this study, the lateral diffusion in the OHC plasma membrane was determined in vitro in guinea pigs by fluorescent recovery after photobleaching (FRAP) after an in vivo noise exposure. The lateral diffusion in the OHC plasma membrane demonstrated a length-dependence, which increased as OHC length increased. A reduction in the lateral diffusion was observed in those OHCs with lengths of 50-70 mu m after exposure to an 8-kHz octave band noise at 110 dB SPL for 3h. This membrane fluidity change was associated with the selective PTS at frequencies around 8 kHz. The reduction of the lateral diffusion in the OHC lateral wall indicated that noise could impair the micromechanics of the OHC lateral wall and might consequently impair OHC electromotility to induce threshold shift. (C) 2006 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
Univ Kentucky, Med Ctr, Div Otolaryngol, Lexington, KY USA.
RP Chen, GD (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM gchen7@buffalo.edu
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NR 63
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 14
EP 21
DI 10.1016/j.heares.2006.06.007
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000003
PM 16870367
ER
PT J
AU Le Prell, CG
Yamashita, D
Minami, SB
Yamasoba, T
Miller, JM
AF Le Prell, Colleen G.
Yamashita, Daisuke
Minami, Shujiro B.
Yamasoba, Tatsuya
Miller, Josef M.
TI Mechanisms of noise-induced hearing loss indicate multiple methods of
prevention
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE noise; hearing loss; antioxidant; cochlea; cell death
ID GUINEA-PIG COCHLEA; TEMPORARY THRESHOLD SHIFT; HAIR CELL-DEATH; FAS
LIGAND TRANSCRIPTION; FIBROBLAST-GROWTH-FACTOR; SPIRAL GANGLION NEURONS;
VITAMIN-A-DEFICIENCY; INTENSE AUDITORY-STIMULATION; GENTAMICIN-INDUCED
COCHLEAR; CISPLATIN-INDUCED APOPTOSIS
AB Recent research has shown the essential role of reduced blood flow and free radical formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant late formation 7-10 days following noise exposure, and one mechanism underlying noise-induced reduction in cochlear blood flow has finally been identified. These new insights have led to the formulation of new hypotheses regarding the molecular mechanisms of NIHL; and, from these, we have identified interventions that prevent NIHL, even with treatment onset delayed up to 3 days post-noise. It is essential to now assess the additive effects of agents intervening at different points in the cell death pathway to optimize treatment efficacy. Finding safe and effective interventions that attenuate NIHL will provide a compelling scientific rationale to justify human trials to eliminate this single major cause of acquired hearing loss. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Karolinska Inst, Ctr Hearing & Commun, Stockholm, Sweden.
Keio Univ Hosp, Dept Otolaryngol, Shinjuku Ku, Tokyo 1608582, Japan.
Univ Tokyo, Dept Otolaryngol, Bunkyo Ku, Tokyo 1138655, Japan.
RP Le Prell, CG (reprint author), Univ Michigan, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM colleeng@umich.edu
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JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 22
EP 43
DI 10.1016/j.heares.2006.10.006
PG 22
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000004
PM 17141991
ER
PT J
AU Kil, J
Pierce, C
Tran, H
Gu, R
Lynch, ED
AF Kil, Jonathan
Pierce, Carol
Tran, Huy
Gu, Rende
Lynch, Eric D.
TI Ebselen treatment reduces noise induced hearing loss via the mimicry and
induction of glutathione peroxidase
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE hearing; noise; glutathione peroxidase; ebselen; otoprotection;
presbycusis
ID NITRIC-OXIDE SYNTHASE; LIPID-PEROXIDATION; ACOUSTIC TRAUMA;
FREE-RADICALS; COCHLEA; ANTIOXIDANT; EXPRESSION; EXPOSURE; OXYGEN; RAT
AB Previous studies indicate that noise induced hearing loss (NIHL) involves a decrease in glutathione peroxidase (GPx) activity and a subsequent loss of outer hair cells (OHC). However, the cellular localization of this GPx decrease and the link to OHC loss are still poorly understood. In this report, we examined the cellular localization of GPx (GPx1, GPx 3 and GPx 4) in F-344 rat before and after noise exposure and after oral treatment with ebselen, a small molecule mimic of GPx activity. Results indicate that GPx1 is the major isoform within the cochlea and is highly expressed in cells of the organ of Corti, spiral ganglia, stria vascularis, and spiral ligament. Within 5h of noise exposure (4h at 113 dB, 4-16 kHz), significant OHC loss was already apparent in regions coincident with the 816 kHz region of the cochlea. In addition, the stria vascularis exhibited significant edema or swelling and a decrease in GPx1 immunoreactivity or fluorescent intensity. Treatment with ebselen (4 mg/kg p.o.) before and immediately after noise exposure reduced both OHC loss and the swelling of the stria vascularis typically observed within 5h post-noise exposure. Interestingly, GPx1 levels increased in the stria vascularis after noise and ebselen treatment vs noise and vehicle-only treatment, and exceeded baseline no noise control levels. These data indicate that ebselen acts to prevent the acute loss of OHCs and reduces the acute swelling of the stria vascularis by two potential mechanisms: one, as a ROS/RNS scavenger through its intrinsic GPx activity, and two, as a stimulator of GPx1 expression or activity. This latter mechanism may be due to the preservation of endogenous GPx I from ROS/RNS induced degradation and/or the stimulation of GPx1 expression or activity. (C) 2006 Elsevier B.V. All rights reserved.
C1 Sound Pharmaceut Inc, Res & Dev, Seattle, WA 98103 USA.
RP Kil, J (reprint author), Sound Pharmaceut Inc, Res & Dev, 4010 Stone Way N Suite 120, Seattle, WA 98103 USA.
EM jkil@soundpharmaceuticals.com
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NR 30
TC 22
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 44
EP 51
DI 10.1016/j.heares.2006.08.006
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000005
PM 17030476
ER
PT J
AU Shen, HY
Zhang, BP
Shin, JH
Lei, DB
Du, Y
Gao, X
Wang, QJ
Ohlemiller, KK
Piccirillo, J
Bao, JX
AF Shen, Haiyan
Zhang, Baoping
Shin, June-Ho
Lei, Debin
Du, Yafei
Gao, Xiang
Wang, Qiuju
Ohlemiller, Kevin K.
Piccirillo, Jay
Bao, Jianxin
TI Prophylactic and therapeutic functions of T-type calcium blockers
against noise-induced hearing loss
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE noise-induced hearing loss; mouse; T-type calcium channel;
trimethadione; ethosuximide
ID PERMANENT THRESHOLD SHIFT; SPIRAL GANGLION NEURONS; GUINEA-PIG COCHLEA;
CHANNEL BLOCKER; AUDITORY-SYSTEM; MOUSE COCHLEA; HAIR-CELLS; INJURY;
EAR; MECHANISMS
AB Cochlear noise injury is the second most frequent cause of sensorineural hearing loss, after aging. Because calcium dysregulation is a widely recognized contributor to noise injury, we examined the potential of calcium channel blockers to reduce noise-induced hearing loss (NIHL) in mice. We focused on two T-type calcium blockers, trimethadione and ethosuximide, which are anti-epileptics approved by the Food and Drug Administration. Young C57BL/6 mice of either gender were divided into three groups: a 'prevention' group receiving the blocker via drinking water before noise exposure; a 'treatment' group receiving the blocker via drinking water after noise exposure; and controls receiving noise alone. Trimethadione significantly reduced NIHL when applied before noise exposure, as determined by auditory brainstem recording. Both ethosuximide and trimethadione were effective in reducing NIHL when applied after noise exposure. Results were influenced by gender, with males generally receiving greater benefit than females. Quantitation of hair cell and neuronal density suggested that preservation of outer hair cells could account for the observed protection. Immunocytochemistry and RT-PCR suggested that this protection involves direct action of T-type blockers on al subunits comprising one or more Ca,3 calcium channel types in the cochlea. Our findings provide a basis for clinical studies testing T-type calcium blockers both to prevent and treat NIHL. (C) 2007 Elsevier B.V. All rights reserved.
C1 Washington Univ, Ctr Aging, Dept Otolaryngol, St Louis, MO 63110 USA.
Nanjing Univ, Model Anim Res Ctr, Nanjing 210061, Peoples R China.
Chinese Peoples Liberat Army Gen Hosp, Dept Otolaryngol, Beijing 100853, Peoples R China.
RP Bao, JX (reprint author), Washington Univ, Ctr Aging, Dept Otolaryngol, 4560 Clayton Ave, St Louis, MO 63110 USA.
EM jbao@wustl.edu
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NR 56
TC 29
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 52
EP 60
DI 10.1016/j.heares.2006.12.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000006
PM 17291698
ER
PT J
AU Canlon, B
Meltser, I
Johansson, P
Tahera, Y
AF Canlon, Barbara
Meltser, Inna
Johansson, Peter
Tahera, Yeasmin
TI Glucocorticoid receptors modulate auditory sensitivity to acoustic
trauma
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE auditory brainstern response; cochlea; corticosterone; glucocorticoid
receptor; NF-kappa B; I kappa B; sprial ganglion neurons; hearing loss;
stress
ID NF-KAPPA-B; SENSORINEURAL HEARING-LOSS; PITUITARY-ADRENOCORTICAL AXIS;
INNER-EAR; MESSENGER-RNA; GUINEA-PIGS; HAIR-CELLS; IN-VITRO;
NEUROTROPHIC FACTOR; RESTRAINT STRESS
AB Glucocorticoids are widely used to treat different hearing disorders yet the exact mechanisms of glucocorticoid action on the inner ear are not known. The inner ear of both humans and experimental animals demonstrate an abundance of glucocorticoid receptors (GRs) in both neuronal and non-neuronal tissues. In this review, we discuss how activation of the hypothalamic-pituitary-adrenal axis can directly modulate hearing sensitivity. Recent findings indicate that several factors define the responsiveness of the peripheral auditory system to glucocorticoids including the concentration of agonist, availability of the GR, and the activation of GR and NF-KB. These findings will further our understanding of individual glucocorticoid responsiveness to steroid treatment, and will help improve the development of pharmaceuticals to selectively target GR in the inner ear for individuals with increased sensitivity to acoustic trauma. (C) 2006 Elsevier B.V. All rights reserved.
C1 Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
RP Canlon, B (reprint author), Karolinska Inst, Dept Physiol & Pharmacol, Von Eulers Vag 8, S-17177 Stockholm, Sweden.
EM barbara.canlon@ki.se
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NR 86
TC 37
Z9 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 61
EP 69
DI 10.1016/j.heares.2006.05.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000007
PM 16843624
ER
PT J
AU Coleman, JKM
Littlesunday, C
Jackson, R
Meyer, T
AF Coleman, John K. M.
Littlesunday, Cherllynn
Jackson, Ronald
Meyer, Thomas
TI AM-111 protects against permanent hearing loss from impulse noise trauma
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE impulse noise; acute acoustic trauma; noise-induced hearing loss;
apoptosis; JNK
ID HAIR CELL-DEATH; ACOUSTIC TRAUMA; SODIUM HYALURONATE; EXPOSURE;
CHINCHILLA; PREVENTION; INHIBITORS; APOPTOSIS; COCHLEA; SYSTEM
AB The otoprotective peptide AM-111, a cell-permeable inhibitor of JNK mediated apoptosis, was tested for its efficacy as a rescue agent following impulse noise trauma. Single dose administrations of AM-111 at 1 h or 4 h post-impulse noise exposure (155 dB peak SPL) via systemic or local routes were evaluated with a total of 48 chinchillas. The animals received the compound either by IP injection or locally onto the round window membrane (hyaluronic acid gel formulation or Osmotic mini-pump). Efficacy was determined by auditory brainstem responses (ABR) as well as cytocochleograms. Three weeks after impulse noise exposure, permanent threshold shifts (PTS) were significantly lower for AM-111 treated ears compared to controls, regardless of the drug administration route and the time point of drug delivery. Even the treatments which started 4h post-noise exposure, reduced hearing loss in the 2-8 kHz range compared to controls by up to 16-25 dB to a PTS as low as 6-17 dB, demonstrating significant protection against permanent hearing loss from impulse noise trauma. These findings suggest a key role for JNK mediated cochlear sensory cell death from oxidative stress. (C) 2006 Elsevier B.V. All rights reserved.
C1 Lab Auris SAS, F-34830 Clapiers, France.
USN, Med Ctr San Diego, Naval Med Ctr Spatial Orientat Ctr, San Diego, CA 92134 USA.
RP Meyer, T (reprint author), Lab Auris SAS, Ave Europe, F-34830 Clapiers, France.
EM thomas.meyer@aurismedical.com
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NR 29
TC 30
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 70
EP 78
DI 10.1016/j.heares.2006.05.006
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000008
PM 16839720
ER
PT J
AU Gagnon, PM
Simmons, DD
Bao, JX
Lei, DB
Ortmann, AJ
Ohlemiller, KK
AF Gagnon, Patricia M.
Simmons, Dwayne D.
Bao, Jianxin
Lei, Debin
Ortmann, Amanda J.
Ohlemiller, Kevin K.
TI Temporal and genetic influences on protection against noise-induced
hearing loss by hypoxic preconditioning in mice
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE cochlea; organ of corti; stria vascularis; HIF-1 alpha; hypoxia;
protection; C57BL/6; CBA
ID ISCHEMIC TOLERANCE; ACOUSTIC INJURY; INNER-EAR; TRANSCRIPTION FACTOR;
MOUSE; COCHLEA; ERYTHROPOIETIN; STRESS; BRAIN; NEUROPROTECTION
AB The protective benefits of hypoxic preconditioning (HPC) against permanent noise-induced hearing loss (NIHL) were investigated in mice. Hypoxia induced by exposure to 8% O-2 for 4 h conferred significant protection against damaging broadband noise delivered 2448 h later in male and female CBA/J (CBA) and CBA/CaJ mice. No protection was found in C57BL/6 (136) mice, their B6.CAST-Cdh23(CAST) (B6.CAST) congenics, or in CBAxB6 F1 hybrid mice over the same interval, suggesting that the potential for HPC depends on one or a few autosomal recessive alleles carried by CBA-related strains, and is not influenced by the Cdh23 locus. Protection against NIHL in CBA mice was associated with significant up-regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) within the organ of Corti, not found in B6.CAST. In both CBA and B6.CAST mice, some hypoxia-noise intervals shorter than 24 h were associated with exacerbation of NIHL. Cellular cascades underlying the early exacerbation of NIHL by hypoxia are therefore common to both strains, and not mechanistically linked to later protection. Elucidation of the events that underlie HPC, and how these are impacted by genetics, may lead to pharmacologic approaches to mimic HPC, and may help identify individuals with elevated risk of NIHL. (C) 2006 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
Washington Univ, Sch Med, Program Audiol & Commun Sci, St Louis, MO USA.
RP Ohlemiller, KK (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, 660 S Euclid, St Louis, MO 63110 USA.
EM kohlemiller@wustl.edu
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ZWEMER ZF, IN PRESS J APPL PHYS
NR 59
TC 12
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 79
EP 91
DI 10.1016/j.heares.2006.09.006
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000009
PM 17107766
ER
PT J
AU Campbell, KCM
Meech, RP
Klemens, JJ
Gerberi, MT
Dyrstad, SSW
Larsen, DL
Mitchell, DL
El-Aziz, M
Verhulst, SJ
Hughes, LF
AF Campbell, Kathleen C. M.
Meech, Robert P.
Klemens, James J.
Gerberi, Michael T.
Dyrstad, Sara S. W.
Larsen, Deb L.
Mitchell, Diana L.
El-Aziz, Mohammed
Verhulst, Steven J.
Hughes, Larry F.
TI Prevention of noise- and drug-induced hearing loss with D-methionine
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE D-methionine; otoprotection; protection; ototoxicity; hearing loss;
cisplatin; noise-induced hearing loss; aminoglycosides
ID VESTIBULAR SENSORY CELLS; CISPLATIN-INDUCED DAMAGE; ROUND WINDOW
APPLICATION; AUDITORY HAIR-CELLS; OTOTOXICITY IN-VIVO; AMINO-ACIDS;
NITRIC-OXIDE; GUINEA-PIG; INDUCED NEPHROTOXICITY; THIOETHER SUPPRESSION
AB A number of otoprotective agents are currently being investigated. Various types of agents have been found in animal studies to protect against hearing loss induced by cisplatin, carboplatin, aminoglycosides, or noise exposure. For over a decade we have been investigating D-methionine (D-met) as an otoprotective agent. Studies in our laboratory and others around the world have documented D-met's otoprotective action, in a variety of species, against a variety of ototoxic insults including cisplatin-, carboplatin-, aminoglycoside- and noise-induced auditory threshold elevations and cochlear hair cell loss. For cisplatin-induced ototoxicity, protection of the stria vascularis has also been documented. Further D-met has an excellent safety profile. D-Met may act as both a direct and indirect antioxidant. In this report, we provide the results of three experiments, expanding findings in D-met protection in three of our translational research areas: protection from platinum based chemotherapy-, aminoglycoside- and noise-induced hearing loss. These experiments demonstrate oral D-Met protection against cisplatin-induced ototoxicity, D-Met protection against amikacin-induced ototoxicity, and D-met rescue from permanent noise-induced hearing loss when D-Met is initiated 1 h after noise exposure. These studies demonstrate some of the animal experiments needed as steps to translate a protective agent from bench to bedside. (C) 2006 Elsevier B.V. All rights reserved.
C1 So Illinois Univ, Sch Med, Springfield, IL 62794 USA.
Univ Chicago, Chicago, IL 60637 USA.
RP Campbell, KCM (reprint author), So Illinois Univ, Sch Med, Springfield, IL 62794 USA.
EM kcampbell@siumed.edu
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1991, DRUG FACTS COMPARISO, P2115
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NR 78
TC 85
Z9 90
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 92
EP 103
DI 10.1016/j.heares.2006.11.012
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000010
PM 17224251
ER
PT J
AU Coleman, JKM
Kopke, RD
Liu, J
Ge, X
Harper, EA
Jones, GE
Cater, TL
Jackson, RL
AF Coleman, J. K. M.
Kopke, R. D.
Liu, J.
Ge, X.
Harper, E. A.
Jones, G. E.
Cater, T. L.
Jackson, R. L.
TI Pharmacological rescue of noise induced hearing loss using
N-acetylcysteine and acetyl-L-carnitine
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE acoustic trauma; N-acetylcysteine; acetyl-L-eysteine; antioxidant; hair
cells; chinchilla; noise; rescue of hearing
ID CELL-DEATH; OXIDATIVE STRESS; HAIR-CELLS; EXPOSURE; APOPTOSIS;
GLUTATHIONE; CHINCHILLA; ELEVATION; DEFENSES; COCHLEA
AB Despite the use of hearing protection devices (HPDs) and engineering changes designed to improve workspaces, noise-induced hearing loss continues to be one of the most common and expensive disabilities in the US military. Many service members suffer acoustic trauma due to improper use of HPDs, sound levels exceeding the protective capacity of the HPDs, or by unexpected, injurious exposures. In these cases, there is no definitive treatment for the hearing loss. This study investigated the use of the pharmacological agents N-acetylcysteine and acetyl-L-carnitine after acoustic trauma to treat cochlear injury. N-Acetylcysteine is an antioxidant and acetyl-L-carnitine a compound that maintains mitochondrial bio-energy and integrity. N-Acetylcysteine and acetyl-L-carnitine, respectively, significantly reduced permanent threshold shifts and hair cell loss compared to saline-treated animals when given I and 4 h post-noise exposure. It may be possible to obtain a greater therapeutic effect using these agents in combination or at higher doses or for a longer period of time to address the secondary oxidative events occurring 7-10 days after acute noise exposure. Published by Elsevier B.V.
C1 USN, Med Ctr, Dept Otolaryngol, Dept Def Spatial Orientat Ctr, San Diego, CA 92134 USA.
Hough Ear Inst, Oklahoma City, OK USA.
RP Jackson, RL (reprint author), USN, Med Ctr, Dept Otolaryngol, Dept Def Spatial Orientat Ctr, San Diego, CA 92134 USA.
EM rjackson@nmcsd.med.navy.mil
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2005, MARINE CORPS LESSONS
NR 48
TC 35
Z9 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 104
EP 113
DI 10.1016/j.heares.2006.08.008
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000011
PM 17023129
ER
PT J
AU Kopke, RD
Jackson, RL
Coleman, JKM
Liu, JZ
Bielefeld, EC
Balough, BJ
AF Kopke, Richard D.
Jackson, Ronald L.
Coleman, John K. M.
Liu, Jianzhong
Bielefeld, Eric C.
Balough, Ben J.
TI NAC for noise: From the bench top to the clinic
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE NAC; NIHL; acute acoustic trauma; hearing loss; treatment
ID INDUCED HEARING-LOSS; TEMPORARY THRESHOLD SHIFT; GUINEA-PIG COCHLEA;
ACETYL-L-CYSTEINE; FREE-RADICAL SCAVENGER; MAP KINASE ACTIVATION; ORAL
MAGNESIUM INTAKE; N-ACETYLCYSTEINE NAC; OUTER HAIR-CELLS; ACOUSTIC
TRAUMA
AB Noise-induced hearing loss (NIHL) is an important etiology of deafness worldwide. Hearing conservation programs are in place and have reduced the prevalence of NIHL, but this disorder is still far too common. Occupational and recreational pursuits expose people to loud noise and ten million persons in the US have some degree of noise-induced hearing impairment. It is estimated that 50 million in the US and 600 million people worldwide are exposed to noise hazards occupationally. Noise deafness is still an important and frequent cause of battlefield injury in the US military. A mainstay of hearing conservation programs is personal mechanical hearing protection devices which are helpful but have inherent limitations. Research has shown that oxidative stress plays an important role in noise-induced cochlear injury resulting in the discovery that a number of antioxidant and cell death inhibiting compounds can ameliorate deafness associated with acoustic trauma. This article reviews one such compound, N-acetylcysteine (NAC), in terms of its efficacy in reducing hearing loss in a variety of animal models of acute acoustic trauma and hypothesizes what its therapeutic mechanisms of action might be based on the known actions of NAC. Early clinical trials with NAC are mentioned. (C) 2006 Elsevier B.V. All rights reserved.
C1 Hough Ear Inst, Oklahoma City, OK 73112 USA.
Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73190 USA.
Univ Oklahoma, Hlth Sci Ctr, Dept Otolaryngol, Oklahoma City, OK 73190 USA.
Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA.
Naval Med Ctr, Dept Defense Spatial Orientat Ctr, San Diego, CA 92134 USA.
SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Kopke, RD (reprint author), Hough Ear Inst, 3400 NW 56th St, Oklahoma City, OK 73112 USA.
EM rkopke@houghearinstitute.com; rjackson@nmcsd.med.navy.mil;
jkcoleman@nmcsd.med.navy.mil; jliu@houghearinstitute.com;
ecb2@buffalo.edu; bjbalough@nmcsd.med.navy.mil
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NR 119
TC 67
Z9 74
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 114
EP 125
DI 10.1016/j.heares.2006.10.008
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000012
PM 17184943
ER
PT J
AU Ding, DL
Jiang, HY
Wang, P
Salvi, R
AF Ding, Dalian
Jiang, Haiyan
Wang, Ping
Salvi, Richard
TI Cell death after co-administration of cisplatin and ethacrynic acid
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE cisplatin; ethacrynic acid; caspase; TRADD; hair cells; chinchilla
ID VESTIBULAR HAIR-CELLS; INDUCED APOPTOSIS; CASPASE ACTIVATION; PROTECTS
COCHLEAR; STRIA VASCULARIS; ANIMAL-MODEL; OTOTOXICITY; RECEPTOR; NOISE;
CHINCHILLAS
AB Ethacrynic acid (EA) significantly enhances the ototoxic effects of cisplatin. To gain insights into the mechanisms underlying Cis/EA ototoxicity, cochleas were labeled with several apoptotic markers. Cis/EA treatment caused extensive outer hair cell (OHC) and inner hair cell (IHC) damage; OHC lesions decreased from the base towards apex of the cochlea whereas the IHC lesion was relatively constant (25-60%) along the length of the cochlea. Propidium iodide labeled OHC nuclei appeared relatively normal at 6 h post-treatment, were condensed and fragmented at 12 h post-treatment and were frequently missing 48 h post-treatment. Initiator caspase 8, associated with membrane death receptors, and TRADD, a protein that recruits caspase 8, were present in OHC at 6 h post-treatment. Caspase 8 labeling increased from 6 to 24 It, but was largely absent at 48 h post-treatment. Executioner caspase 3 and caspase 6, which lie downstream of caspase 8, were expressed in OHC 12-24 h post-treatment. Initiator caspase 9, associated with mitochondrial damage, was only expressed at low levels at 48 h post-treatment. These results suggest that the rapid onset of Cis/EA induced programmed cell death is initiated by membrane death receptors associated with TRADD and caspase 8. (C) 2006 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Salvi, R (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall, Buffalo, NY 14214 USA.
EM salvi@buffalo.edu
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NR 34
TC 27
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 129
EP 139
DI 10.1016/j.heares.2006.07.015
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000013
PM 16978814
ER
PT J
AU Coling, DE
Ding, DL
Young, R
Lis, M
Stofko, E
Blumenthal, KM
Salvi, RJ
AF Coling, Donald E.
Ding, Dalian
Young, Rebeccah
Lis, Maciej
Stofko, Elizabeth
Blumenthal, Kenneth M.
Salvi, Richard J.
TI Proteomic analysis of cisplatin-induced cochlear damage: Methods and
early changes in protein expression
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE proteomics; cochlea; inner ear; cisplatin; stress response; DIGE; MALDI;
mass spectrometry; peptide mass fingerprint; nucleobindin; Hspa5; Grp78;
BiP; Grp58; Pdia3; Rnh1; Rasl12; Hnrpc; Ptpdc1; calreticulin; Edf1;
Tuba6; Rassf5
ID CALCIUM-BINDING PROTEIN; HEAT-SHOCK-PROTEIN; SENSORINEURAL HEARING-LOSS;
VESTIBULAR HAIR-CELLS; ENDOPLASMIC-RETICULUM; RAT COCHLEA; GUINEA-PIG;
DISULFIDE-ISOMERASE; INDUCED APOPTOSIS; IN-VIVO
AB To identify early changes in protein expression associated with cisplatin ototoxicity, we used two dimensional-difference gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption-time-of-flight (MALDI-TOF) mass spectrometry to analyze proteins from P3 rat cochleae that were cultured for 3 h with or without 1 mM cisplatin. Replicate analysis of fluorescent images from six gels revealed significant (p < 0.01) cisplatin-induced changes (greater than 1.5-fold) in expression of 22 cochlear proteins. These include increases in the expression of five proteins, four of which were identified as nucleobindin 1, a nuclear calcium signaling and, homeostasis protein (2.1-fold), heterogeneous nuclear ribonucleoprotein C, an RNA processing protein (1.8-fold), a 55 kDa protein that is either endothelial differentiation-related factor 1 or alpha-6 tubulin (1.7-fold), and calreticulin, a calcium binding chaperone of the endoplasmic reticulum (ER, 1.6-fold). The expression of 17 proteins was significantly (p < 0.01) decreased by greater than 1.5-fold. These include ribonuclease/ angiogenin inhibitor 1 (1.6-fold), RAS-like, family 12 (predicted), ras association (RaIGDS/AF-6) domain family 5 (4.5-fold), homologous the RAS family of GTPase signaling proteins (2.4-fold), and Protein tyrosine phosphatase domain containing 1 (predicted, 6.1-fold). We identified seven cochlear proteins with either smaller (1.2-1.5-fold) or less significant (p < 0.05) cisplatin-induced changes in expression. Notably, heat shock 70 kDa protein 5 (Hspa5, Grp78, and BiP), an ER chaperone protein involved in stress response, decreased 1.7-fold. We observed changes consistent with phosphorylation in the level of isoforms of another ER stress-induced protein, glucose-regulated protein Grp58. Changes in cisplatin-induced protein expression are discussed with respect to known or hypothesized functions of the identified proteins. (C) 2007 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
SUNY Buffalo, Dept Med, Buffalo, NY 14214 USA.
SUNY Buffalo, Dept Biochem, Buffalo, NY 14214 USA.
RP Coling, DE (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall, Buffalo, NY 14214 USA.
EM dcoling@buffalo.edu
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NR 75
TC 29
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 140
EP 156
DI 10.1016/j.heares.2006.12.017
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000014
PM 17321087
ER
PT J
AU Rybak, LP
Whitworth, CA
Mukherjea, D
Rarakumar, V
AF Rybak, Leonard P.
Whitworth, Craig A.
Mukherjea, Debashree
Rarakumar, Vickram
TI Mechanisms of cisplatin-induced ototoxicity and prevention
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE cisplatin; reactive oxygen species; apoptosis; NADPH; oxidase
ID INDUCED HEARING-LOSS; HIGH-DOSE CISPLATIN; ROUND WINDOW APPLICATION;
SPIRAL GANGLION NEURONS; APOPTOTIC CELL-DEATH; AUDITORY HAIR-CELLS;
SODIUM THIOSULFATE; D-METHIONINE; STRIA VASCULARIS; N-ACETYLCYSTEINE
AB Cisplatin is a widely used chemotherapeutic agent to treat malignant disease. Unfortunately, ototoxicity occurs in a large percentage of patients treated with higher dose regimens. In animal studies and in human temporal bone investigations, several areas of the cochlea are damaged, including outer hair cells in the basal turn, spiral ganglion cells and the stria vascularis, resulting in hearing impairment. The mechanisms appear to involve the production of reactive oxygen species (ROS), which can trigger cell death. Approaches to chemoprevention include the administration of antioxidants to protect against ROS at an early stage in the ototoxic pathways and the application of agents that act further downstream in the cell death cascade to prevent apoptosis and hearing loss. This review summarizes recent data that shed new light on the mechanisms of cisplatin ototoxicity and its prevention. (C) 2006 Elsevier B.V. All rights reserved.
C1 So Illinois Univ, Sch Med, Div Otolaryngol, Dept Surg, Springfield, IL 62794 USA.
So Illinois Univ, Dept Pharmacol, Carbondale, IL 62901 USA.
RP Rybak, LP (reprint author), So Illinois Univ, Sch Med, Div Otolaryngol, Dept Surg, POB 19653, Springfield, IL 62794 USA.
EM lrybak@siumed.edu; cwhitworth@siu-med.edu; dmukherjea@siumed.edu;
vramkumar@siumed.edu
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NR 82
TC 171
Z9 183
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 157
EP 167
DI 10.1016/j.heares.2006.09.015
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000015
PM 17113254
ER
PT J
AU Eshraghi, AA
Wang, J
Adil, E
He, J
Zine, A
Bublik, M
Bonny, C
Puel, JL
Balkany, TJ
Van de Water, TR
AF Eshraghi, Adrien A.
Wang, Jing
Adil, Eelam
He, Jiao
Zine, Azel
Bublik, Michael
Bonny, Christophe
Puel, Jean-Luc
Balkany, Thomas J.
Van de Water, Thomas R.
TI Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss
induced by both electrode insertion trauma and neomycin ototoxicity
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE hearing loss; electrode insertion trauma; aminoglycoside ototoxicity;
otoprotection; JNK signaling; hair cells; apoptosis; D-JNKI-1 peptide
(AM-111)
ID COCHLEAR IMPLANTATION TRAUMA; HAIR CELL-DEATH; FORMATION IN-VITRO;
GENTAMICIN OTOTOXICITY; CHINCHILLA COCHLEA; CASPASE ACTIVATION; INDUCED
APOPTOSIS; FREE-RADICALS; AMINOGLYCOSIDE; PROTECTS
AB Neomycin ototoxicity and electrode insertion trauma both involve activation of the mitogen activated protein kinase (MAPK)/c-Jun-N-terminal kinase (JNK) cell death signal cascade. This article discusses mechanisms of cell death on a cell biology level (e.g. necrosis and apoptosis) and proposes the blocking of JNK signaling as a therapeutic approach for preventing the development of a permanent hearing loss that can be initiated by either neomycin ototoxicity or electrode insertion trauma. Blocking of JNK molecules incorporates the use of a peptide inhibitor (i.e. D-JNKI-1), which is specific for all three isoforms of JNK and has been demonstrated to prevent loss of hearing following either electrode insertion trauma or loss of both hearing and hair cells following exposure to an ototoxic level of neomycin. We present previously unpublished results that control for the effect of perfusate washout of aminoglycoside antibiotic by perfusion of the scala tympani with an inactive form of D-JNKI-1 peptide, i.e. JNKI-1(mut) peptide, which was not presented in the original J. Neurosci. article that tested locally delivered D-JNKI-1 peptide against both noise- and neomycin-induced hearing loss (i.e. Wang, J., Van De Water, T.R., Bonny, C., de Ribaupierre, F., Puel, J.L., Zinc, A. 2003a. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J. Neurosci. 23, 8596-8607). D-JNKI-1 is a cell permeable peptide that blocks JNK signaling at the level of the three JNK molecular isoforms, which when blocked prevents the increases in hearing thresholds and the loss of auditory hair cells. This unique therapeutic approach may have clinical application for preventing: (1) hearing loss caused by neomycin ototoxicity; and (2) the progressive component of electrode insertion trauma-induced hearing loss. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Miami, Miller Sch Med, Dept Otolaryngol, Ear Inst,Cochlear Implant Res Program, Miami, FL 33136 USA.
Univ Montpellier 1, INSERM, U583, Montpellier, EU, France.
Univ Lausanne, CH-1015 Lausanne, Switzerland.
RP Van de Water, TR (reprint author), Univ Miami, Miller Sch Med, Dept Otolaryngol, Ear Inst,Cochlear Implant Res Program, 1600 NW 10th Ave,RMSB 3160, Miami, FL 33136 USA.
EM tvandewater@med.miami.edu
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NR 48
TC 51
Z9 53
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 168
EP 177
DI 10.1016/j.heares.2006.09.008
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000016
PM 17098385
ER
PT J
AU Chen, Y
Huang, WG
Zha, DJ
Qiu, JH
Wang, JL
Sha, SH
Schacht, J
AF Chen, Yang
Huang, Wei-Guo
Zha, Ding-Jun
Qiu, Jian-Hua
Wang, Jin-Ling
Sha, Su-Hua
Schacht, Jochen
TI Aspirin attenuates gentamicin ototoxicity: From the laboratory to the
clinic
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE aminoglycosides; ototoxicity; antioxidant therapy; salicylate
ID HAIR CELL-DEATH; PIG IN-VIVO; AMINOGLYCOSIDE-INDUCED OTOTOXICITY;
INDUCED HEARING-LOSS; CYSTIC-FIBROSIS; IRON CHELATORS; INDUCED COCHLEAR;
TOXICITY; PROTECTS; THERAPY
AB This article reviews recent advances in the protection from the adverse auditory or vestibular side effects associated with antibacterial treatment with aminoglycoside antibiotics. Compelling evidence from animal models suggests that reactive oxygen species are part of the initial mechanisms that trigger apoptotic and necrotic cell death in the inner car. Consequently, antioxidants protect against aminoglycoside-induced hearing loss in animals and, importantly, they do so without compromising drug serum levels or antibacterial efficacy. While clinical studies have long confirmed the ototoxicity of aminoglycosides in human, a trial on protection was only recently reported (Sha, S.-H., Qiu, J.-H., Schacht, J., 2006. Aspirin attenuates gentamicin-induced hearing loss. New Engl. J. Med. 354, 1856-1857). Based on the finding that salicylate afforded protection in animals, the efficacy of aspirin (acetyl salicylate) was tested in a randomized double-blind placebo-controlled study in patients receiving gentamicin for acute infections. Fourteen of 106 patients (13%) met the criterion of hearing loss in the placebo group while only 3/89 (3%) were affected in the aspirin group (p = 0.013). Aspirin did not influence gentamicin serum levels or the course of therapy. These results indicate that therapeutic protection from aminoglycoside ototoxicity may be extrapolated from animal models to the clinic. Furthermore, medications as common as aspirin can significantly attenuate the risk of gentamicin-induced hearing loss. (C) 2006 Elsevier B.V. All rights reserved.
C1 Fourth Mil Med Univ, Xijing Hosp, Dept Otolaryngol, Xian, Peoples R China.
Univ Michigan, Dept Otolaryngol, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
RP Schacht, J (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Otolaryngol, Xian, Peoples R China.
EM schacht@umich.edu
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NR 38
TC 56
Z9 65
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 178
EP 182
DI 10.1016/j.heares.2006.05.008
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000017
PM 16844331
ER
PT J
AU Yamasoba, T
Someya, S
Yamada, C
Weindruch, R
Prolla, TA
Tanokura, M
AF Yamasoba, Tatsuya
Someya, Shinichi
Yamada, Chikako
Weindruch, Richard
Prolla, Tomas A.
Tanokura, Masaru
TI Role of mitochondrial dysfunction and mitochondrial DNA mutations in
age-related hearing loss
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE presbycusis; mitochondrial DNA; aging; germanium; cochlea
ID GENE-EXPRESSION PROFILE; DIETARY RESTRICTION; CALORIC RESTRICTION;
TEMPORAL BONE; OLD RATS; MOLECULAR-MECHANISMS; COCHLEAR PATHOLOGY;
OXIDATIVE DAMAGE; POINT MUTATION; MICE
AB Mitochondrial DNA (mtDNA) mutations/deletions are considered to be associated with the development of age-related hearing loss (AHL). We assessed the role of accumulation of mtDNA mutations in the development of AHL using Polg(D257A) knock-in mouse, which exhibited increased spontaneous mtDNA mutation rates during aging and showed accelerated aging primarily due to increased apoptosis. They exhibited moderate hearing loss and degeneration of the hair cells, spiral ganglion cells and stria vascularis by 9 month of age, while wild-type animals did not. We next examined if mitochondrial damage induced by systemic application of germanium dioxide caused progressive hearing loss and cochlear damage. Guinea pigs and mice given germanium dioxide exhibited degeneration of the muscles and kidney and developed hearing loss due to degeneration of cochlear tissues, including the stria vascularis. Calorie restriction, which causes a metabolic shift toward increased energy metabolism in some organs, has been shown to attenuate AHL and age-related cochlear degeneration and to lower quantity of mtDNA deletions in the cochlea of mammals. Together these findings indicate that decreased energy metabolism due to accumulation of mtDNA mutations/deletions and decline of respiratory chain function play an important role in the manifestation of AHL. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Tokyo, Dept Otolaryngol, Tokyo 1138665, Japan.
Univ Tokyo, Dept Head & Neck Surg, Tokyo 1138665, Japan.
Univ Tokyo, Dept Appl Biol Chem, Tokyo, Japan.
Univ Wisconsin, Dept Genet & Med Genet, Madison, WI 53706 USA.
Univ Wisconsin, Madison, WI 53706 USA.
Vet Adm Geriatr Res Educ & Clin Ctr, Madison, WI USA.
RP Yamasoba, T (reprint author), Univ Tokyo, Dept Otolaryngol, Hongo 7-3-1, Tokyo 1138665, Japan.
EM tyamasoba-tky@umin.ac.jp
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NR 52
TC 44
Z9 49
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 185
EP 193
DI 10.1016/j.heares.2006.06.004
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000018
PM 16870370
ER
PT J
AU Le, T
Keithley, EM
AF Le, Tima
Keithley, Elizabeth M.
TI Effects of antioxidants on the aging inner ear
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE cochlea; beagle dogs; auditory neurons; stria vascularis
ID ALPHA-LIPOIC ACID; ACETYL-L-CARNITINE; NEURONAL SIGNAL-TRANSDUCTION;
QUIET-AGED GERBILS; HAIR CELL LOSS; OXIDATIVE DAMAGE; HEARING-LOSS; OLD
RATS; SUPEROXIDE-DISMUTASE; VITAMIN-E
AB Age-related cochlear structural changes include the degeneration of sensory, neural cells and the stria vascularis. The hypothesis that cellular degeneration results from exposure to oxidative products of respiration was tested by supplementing aged dogs with a diet high in antioxidants and mitochondrial metabolites and by genetically modifying the expression level of the antioxidant, manganese superoxide dismutase (SOD) in mice. Aged dogs received either a high antioxidant diet or a normal, control diet for the last 3 years of their life. Cellular measures were compared among the two aged groups (10-15 years) and young dogs. Both aged groups had cellular degeneration relative to young dogs, but the animals fed the antioxidant diet showed less degeneration at the base and apex than the control-diet group. Transgenic mice, heterozygous null for SOD2 produce only half as much enzyme as a normal mouse. These mice showed no increase in the amount of hearing loss relative to the background strain. A diet containing antioxidants reduced the magnitude of cochlear degeneration. Genetic reduction of one antioxidant, however, did not increase the magnitude of hearing loss in aging mice. A reduction in one enzyme seems to be compensated while the addition of a complex of factors is effective. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Calif San Diego, La Jolla, CA 92093 USA.
RP Keithley, EM (reprint author), Univ Calif San Diego, 9500 Gilman Dr, La Jolla, CA 92093 USA.
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NR 55
TC 33
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 194
EP 202
DI 10.1016/j.heares.2006.04.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000019
PM 16843623
ER
PT J
AU Davis, RR
Kuo, MW
Stanton, SG
Canlon, B
Krieg, E
Alagramam, KN
AF Davis, Rickie R.
Kuo, Ming-Wen
Stanton, Susan G.
Canlon, Barbara
Krieg, Edward
Alagramam, Kumar N.
TI N-Acetyl L-cysteine does not protect against premature age-related
hearing loss in C57BL/6J mice: A pilot study
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE presbycusis; age-related; hearing loss; mouse; reactive oxygen species;
cochleogram; auditory brainstem response
ID MOUSE; STRAINS; CELLS
AB A compound capable of preventing age-related hearing loss would be very useful in an aging population. N-acetyl-L-cysteine (L-NAC) has been shown to be protective against noise exposure, a condition that leads to increased oxidative stress. Not withstanding environmental factors, there is evidence that age-related hearing loss (AHL) in the mouse is linked to more than one genetic loci and, by extension, in humans. Our hypothesis is that AHL defect results in increased sensitivity to oxidative stress and L-NAC would be able to protect the hearing of a mouse model of pre-mature AHL, the C57BL/6J (136) mouse strain. L-NAC was added to the regular water bottle of B6 mice (experimental group) and available ad lib. The other group received normal tap water. Hearing was tested monthly by the ability to generate the auditory brainstem response (ABR). After the final ABR test, mice were sacrificed by an overdose of Avertin, ears were harvested and hair cell loss was quantified. There was no difference in ABR thresholds or in histopathology between the control group and the group receiving L-NAC in their drinking water. In contrast to the protective effects Of L-NAC against noise-induced hearing loss, the lack of protective effect in this study may be due to (i) the dosage level; (ii) the duration of treatment; (iii) the biochemical mechanisms underlying age-induced hearing loss; or (iv) how the mouse metabolizes L-NAC. (C) 2006 Elsevier B.V. All rights reserved.
C1 NIOSH, Hearing Loss Prevent Team, Engn & Phys Hazard Branch, Div Appl Res & Technol, Cincinnati, OH 45226 USA.
Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA.
Univ Cincinnati, Ctr Med, Coll Allied Hlth Sci, Dept Commun Sci & Disorders, Cincinnati, OH 45221 USA.
Karolinska Inst, Dept Physiol & Pharmacol, S-10401 Stockholm, Sweden.
Case Western Reserve Univ, HNS, Dept Otolaryngol, Cleveland, OH 44106 USA.
RP Davis, RR (reprint author), NIOSH, Hearing Loss Prevent Team, Engn & Phys Hazard Branch, Div Appl Res & Technol, C-27,Columbia Pjwy, Cincinnati, OH 45226 USA.
EM rrd1@cdc.gov
RI Davis, Rickie/A-3186-2008
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NR 15
TC 14
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 203
EP 208
DI 10.1016/j.heares.2006.07.003
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000020
PM 16930891
ER
PT J
AU Trune, DR
Kempton, JB
Harrison, AR
Wobig, JL
AF Trune, Dennis R.
Kempton, J. Beth
Harrison, Andrew R.
Wobig, John L.
TI Glucocorticoid impact on cochlear function and systemic side effects in
autoimmune CIMRL-Fas(1pr) and normal C3H/HeJ mice
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE autoimmune hearing loss; C3MRL-Fas(lpr) autoimmune mice; C3H/HeJ mice;
prednisolone; systemic lupus erythematosus; steroid side effects
ID SENSORINEURAL HEARING-LOSS; NF-KAPPA-B; LUPUS-ERYTHEMATOSUS PATIENTS;
INNER-EAR; STEROID TREATMENT; MENIERES-DISEASE; GUINEA-PIG; AUDITORY
FUNCTION; MOUSE; DEXAMETHASONE
AB Glucocorticoids are effective in reversing hearing loss, but their severe side effects limit long term management of many ear disorders. A clearer understanding of these side effects is critical for prolonged therapeutic control of hearing and vestibular dysfunction. Therefore, this study characterized the impact of the glucocorticoid prednisolone on cochlear dysfunction and systemic organ systems in C3.MRL-Fas(lpr). autoimmune mice and their normal C3H/HeJ parent strain. Following 3 months of treatment, autoimmune mice had better auditory thresholds and improved hematocrits, anti-nuclear antibodies, and immune complexes. Steroid treatment also lowered body and spleen weights, both of which rise with systemic autoimmune disease. Steroid treatment of the normal C3H/HeJ mice significantly elevated their blood hematocrits and lowered their body and spleen weights to abnormal levels. Thus, systemic autoimmune disease and its related hearing loss in C3.MRL-Fas(lpr) mice are steroid-responsive, but normal hemopoiesis and organ functions can be significantly compromised. This mouse model may be useful for studies of the detrimental side effects of steroid treatments for hearing loss. (C) 2006 Elsevier B.V. All rights reserved.
C1 Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
Oregon Hlth & Sci Univ, Dept Ophthalmol, Portland, OR 97201 USA.
RP Trune, DR (reprint author), Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM truned@ohsu.edu
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NR 58
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 209
EP 217
DI 10.1016/j.heares.2006.09.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000021
PM 17098384
ER
PT J
AU Robinson, SK
Viirre, ES
Stein, MB
AF Robinson, Shannon K.
Viirre, Erik S.
Stein, Murray B.
TI Antidepressant therapy in tinnitus
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE tinnitus; antidepressants
ID PSYCHIATRIC DIAGNOSES; SUBJECTIVE TINNITUS; AMITRIPTYLINE; IMIPRAMINE;
TRIAL; DISORDERS; NORTRIPTYLINE; ASSOCIATION; COMORBIDITY; VENLAFAXINE
AB Objective: Review the literature on the co-morbidity of depression and anxiety with tinnitus. Briefly consider proposed mechanisms by which antidepressants might be helpful for tinnitus, including treatment of co-morbid depression and anxiety and a more direct serotonergic mechanism of tinnitus. Survey the literature on antidepressants and tinnitus including tinnitus reported as a side effect of antidepressants (phenelzine, amitriptyline, protriptyline, doxepin, imipramine, fluoxetine, trazadone, bupropion, venlafaxine), tinnitus associated with withdrawal of antidepressants (venlafaxine and sertraline) and antidepressants as a treatment for tinnitus (case reports-fluoxetine and paroxetine, retrospective reviews - imipramine and selective serotonin reuptake inhibitors, single blind trials of amitriptyline and double blind placebo controlled trials of trimipramine, nortriptyline, paroxetine and sertraline). Provide suggestions on future directions, specifically replication of prior studies and a dose finding study of paroxetine for the treatment of tinnitus. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Calif San Diego, Sch Med, Vet Adm San Diego Healthcare Syst, Dept Psychiat, La Jolla, CA 92161 USA.
Univ Calif San Diego, Dept Surg, Div Otolaryngol Head & Neck Surg, San Diego, CA 92039 USA.
Univ Calif San Diego, Vet Adm San Diego Healthcare Syst, Sch Med, Dept Psychiat, San Diego, CA 92039 USA.
Univ Calif San Diego, Vet Adm San Diego Healthcare Syst, Sch Med, Dept Family & Prevent Med, San Diego, CA 92039 USA.
RP Robinson, SK (reprint author), Univ Calif San Diego, Sch Med, Vet Adm San Diego Healthcare Syst, Dept Psychiat, La Jolla, CA 92161 USA.
EM skrobinson@ucsd.edu; eviirre@ucsd.edu; mstein@ucsd.edu
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NR 55
TC 26
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 221
EP 231
DI 10.1016/j.heares.2006.08.004
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000022
PM 16973315
ER
PT J
AU Kaltenbach, JA
Zhang, JS
AF Kaltenbach, James A.
Zhang, Jinsheng
TI Intense sound-induced plasticity in the dorsal cochlear nucleus of rats:
Evidence for cholinergic receptor upregulation
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE dorsal cochlear nucleus; noise exposure; carbachol; atropine;
plasticity; tinnitus
ID SPONTANEOUS NEURAL ACTIVITY; PRIMARY AUDITORY-CORTEX; INDUCED
HEARING-LOSS; HAIR CELL LOSS; INFERIOR COLLICULUS; ACOUSTIC TRAUMA;
BRAIN-STEM; GUINEA-PIG; INDUCED HYPERACTIVITY; SYNAPTIC ENDINGS
AB Previous studies in a number of species have demonstrated that spontaneous activity in the dorsal cochlear nucleus (DCN) becomes elevated following exposure to intense sound. This condition of hyperactivity has aroused considerable interest because it may represent an important neural correlate of tinnitus. There is some evidence that neurons in the superficial DCN, such as cartwheel, stellate and fusiform cells, may contribute to the level of hyperactivity induced by intense sound, although the relative importance of these different cell types is unknown. In the present study, we sought to determine the effect of intense sound exposure on multiunit spontaneous activity both at the DCN surface and in the fusiform. cell layer and to examine the influence of cholinergic input to DCN circuits on the level of activity in the fusiform cell layer. Rats were studied in two groups, one of which had been exposed to a continuous intense sound (10 kHz 127 dB SPL) for 4 h while the other group served as unexposed controls. Between 30 and 52 days post-exposure, recordings of multiunit activity were performed at the DCN surface as well as in the middle of the fusiform cell layer. Changes in fusiform cell layer activity were also studied in response to superficial applications of the cholinergic agonist, carbachol, either alone or following pre-application of the cholinergic antagonist, atropine. The results demonstrated that multiunit spontaneous activity in the rat DCN was generally much higher in both control and exposed animals relative to that which has been observed in other species. This activity was significantly higher at the DCN surface of sound-exposed animals than that of controls. In contrast, hyperactivity could not be demonstrated in the fusiform cell layer of sound-exposed animals. Carbachol administration most commonly caused suppression of fusiform cell layer activity. However, this suppression was considerably stronger in the DCN of sound-exposed animals than in controls. These findings suggest that, hyperactivity at the DCN surface of exposed rats may arise as a consequence of more highly activated neurons in the molecular layer, such as cartwheel and/or stellate cells, and that the lack of hyperactivity in the fusiform cell layer may be the result of inhibition of fusiform cells by these inhibitory interneurons. Although this finding does not rule out fusiform cells as possible sources of hyperactivity in other species, or even in the rat after short post-exposure recovery periods, the enhanced sensitivity of the fusiform cell layer to cholinergic stimulation suggests that in the rat, at least after prolonged post-exposure recovery periods, increased inhibition of activity in this layer by more superficially located neurons may result from an upregulation of receptors for cholinergic input. This upregulation may be greater in rats than in other species due to the relatively heavy cholinergic input that exists in the cochlear nucleus of this species. (C) 2006 Elsevier B.V. All rights reserved.
C1 Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Detroit, MI 48201 USA.
RP Kaltenbach, JA (reprint author), Wayne State Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Detroit, MI 48201 USA.
EM jkalten@med.wayne.edu
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NR 57
TC 33
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 232
EP 243
DI 10.1016/j.heares.2006.07.001
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000023
PM 16914276
ER
PT J
AU Yang, G
Lobarinas, E
Zhang, LY
Turner, J
Stolzberg, D
Salvi, R
Sun, W
AF Yang, Guang
Lobarinas, Edward
Zhang, Liyan
Turner, Jeremy
Stolzberg, Daniel
Salvi, Richard
Sun, Wei
TI Salicylate induced tinnitus: Behavioral measures and neural activity in
auditory cortex of awake rats
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Pharmcological Strategies for Prevention and Treatment of
Hearing Loss and Tinnitus
CY OCT 12, 2005
CL Niagara Falls, CANADA
SP Amer Bio Hlth, Auris Med, CepTor, State Univ New York Buffalo, Col Arts & Sci, John R Oishei Fdn, Kinex Pharmaceut, Natl Inst Occupat Safety & Hlth, Off Naval Res, Sound Pharmaceut, Spectra Serv, Tucker Davis Technol, US Army Med Res & Mat Command
DE salicylate; tinnitus; auditory cortex; spontaneous activity; behavior;
startle reflex; field potential
ID DORSAL COCHLEAR NUCLEUS; INFERIOR COLLICULUS; ANIMAL-MODEL; OTOTOXICITY;
NEURONS; CISPLATIN; RESPONSES; SOUND; ISOFLURANE; FREQUENCY
AB Neurophysiological studies of salicylate-induced tinnitus have generally been carried out under anesthesia, a condition that abolishes the perception of tinnitus and depresses neural activity. To overcome these limitations, measurement of salicylate induced tinnitus were obtained from rats using schedule induced polydipsia avoidance conditioning (SIPAC) and gap pre-pulse inhibition of acoustic startle (GPIAS). Both behavioral measures indicated that tinnitus was present after treatment with 150 and 250 mg/kg of salicylate; measurements with GPIAS indicated that the pitch of the tinnitus was near 16 kHz. Chronically implanted microwire electrode arrays were used to monitor the local field potentials and spontaneous discharge rate from multiunit clusters in the auditory cortex of awake rats before and after treatment with 150 mg/kg of salicylate. The amplitude of the local field potential elicited with 60 dB SPL tone bursts increased significantly 2 h after salicylate treatment particularly at 16-20 kHz; frequencies associated with the tinnitus pitch. Field potential amplitudes had largely recovered 1-2 days post-salicylate when behavioral results showed that tinnitus was absent. The mean spontaneous spike recorded from the same multiunit cluster pre- and post-salicylate decreased from 22 spikes/s before treatment to 14 spikes/s 2 h post-salicylate and recovered I day post-treatment. These preliminary physiology data suggest that salicylate induced tinnitus is associated with sound evoked hyperactivity in auditory cortex and spontaneous hypoactivity. (C) 2006 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
YueYang Hosp, Dept Otolaryngol, Shanghai, Peoples R China.
So Illinois Univ, Sch Med, Dept Surg Otolaryngol & Pharmacol, Carbondale, IL 62901 USA.
RP Sun, W (reprint author), SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
EM weisun@buffalo.edu
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NR 44
TC 94
Z9 104
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2007
VL 226
IS 1-2
BP 244
EP 253
DI 10.1016/j.heares.2006.06.013
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 162UW
UT WOS:000246116000024
PM 16904853
ER
PT J
AU Cooper, HR
Roberts, B
AF Cooper, Huw R.
Roberts, Brian
TI Auditory stream segregation of tone sequences in cochlear implant
listeners
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Implantable Auditory Prostheses
CY AUG, 2005
CL Asilomar, CA
DE auditory grouping; stream segregation; pitch discrimination; cochlear
implants
ID SPEECH RECOGNITION; GAP DETECTION; HEARING; PERCEPTION; FREQUENCY;
STIMULATION; PATTERNS; MUSIC
AB Previous claims that auditory stream segregation occurs in cochlear implant listeners are based on limited evidence. In experiment 1, eight listeners heard tones presented in a 30-s repeating ABA-sequence, with frequencies matching the centre frequencies of the implant's 22 electrodes. Tone A always stimulated electrode I I (centre of the array); tone B stimulated one of the others. Tone repetition times (TRTs) from 50 to 200 ms were used. Listeners reported when they heard one or two streams. The proportion of time that each sequence was reported as segregated was consistently greater with increased electrode separation. However, TRT had no significant effect, and the perceptual reversals typical of normal-hearing listeners rarely occurred. The results may reflect channel discrimination rather than stream segregation. In experiment 2, six listeners performed a pitch-ranking task using tone pairs (reference = electrode 11). Listeners reported which tone was higher in pitch (or brighter in timbre) and their confidence in the pitch judgement. Similarities were observed in the individual pattern of results for reported segregation and pitch discrimination. Many implant listeners may show little or no sign of automatic stream segregation owing to the reduced perceptual space within which sounds can differ from one another. (c) 2006 Elsevier B.V. All rights reserved.
C1 Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England.
Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England.
RP Cooper, HR (reprint author), Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England.
EM cooperhr@aston.ac.uk
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NR 28
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 11
EP 24
DI 10.1016/j.heares.2006.11.010
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000002
PM 17257790
ER
PT J
AU Thomassen, HA
Gea, S
Maas, S
Bout, RG
Dirckx, JJJ
Decraemer, WF
Povel, GDE
AF Thomassen, Henri A.
Gea, Stefan
Maas, Steve
Bout, Ron G.
Dirckx, Joris J. J.
Decraemer, Willem F.
Povel, G. David E.
TI Do Swiftlets have an ear for echolocation? The functional morphology of
Swiftlets' middle ears
SO HEARING RESEARCH
LA English
DT Article
DE echolocation; Swiftlet; middle ear; modelling; mu CT; 3D reconstruction
ID CAVE SWIFTLETS; GREY SWIFTLET; CLICKS; SENSITIVITY; OILBIRD; HEARING
AB The Oilbird and many Swiftlet species are unique among birds for their ability to echolocate. Echolocaters may benefit from improved hearing sensitivity. Therefore, morphological adaptations to echolocation might be present in echolocating birds' middle ears. We studied the functional morphology of the tympano-ossicular chain of seven specimens of four echolocating Swiftlet species and one specimen each of five non-echolocating species. Three dimensional (31)) reconstructions were made from micro-Computer-Tomographic (mu CT) scans. The reconstructions were used in functional morphological analyses and model calculations. A two dimensional (21)) rigid rod model with fixed rotational axes was developed to study footplate output-amplitudes and to describe how changes in the arrangement of the tympano-ossicular chain affect its function. A 3D finite element model was used to predict ossicular-chain movement and to investigate the justification of the 2D approach. No morphological adaptations towards echolocation were found in the middle-ear lever system or in the mass impedance of the middle ear. A wide range of middle-ear configurations result in maximum output-amplitudes and all investigated species are congruent with these predicted best configurations. Echolocation is unlikely to depend on adaptations in the middle ear tympano-ossicular chain. (c) 2006 Elsevier B.V. All rights reserved.
C1 Leiden Univ, Inst Biol Leiden, Sect Evolutionary Morphol, NL-2300 RA Leiden, Netherlands.
Univ Antwerp, Dept Phys, Lab Biomed Phys, B-2020 Antwerp, Belgium.
RP Thomassen, HA (reprint author), Leiden Univ, Inst Biol Leiden, Sect Evolutionary Morphol, POB 9516, NL-2300 RA Leiden, Netherlands.
EM h.thomassen@biology.leidenuniv.nl
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NR 31
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 25
EP 37
DI 10.1016/j.heares.2006.11.013
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000003
PM 17229537
ER
PT J
AU Stainsby, TH
Moore, BCJ
AF Stainsby, Thomas H.
Moore, Brian C. J.
TI The effects of hearing loss on growth-of-masking functions for
sinusoidal and complex-tone maskers with differing phase spectra
SO HEARING RESEARCH
LA English
DT Article
DE growth-of-masking (GOM) functions; forward masking; compression;
suppression; sensorineural hearing loss; linear temporal integrator
ID BASILAR-MEMBRANE NONLINEARITY; TEMPORAL INTEGRATION; IMPAIRED SUBJECTS;
NORMALLY HEARING; COMPONENT PHASE; AUDITORY-SYSTEM; TUNING CURVES; DEAD
REGIONS; SIGNAL DELAY; COMPRESSION
AB Growth-of-masking (GOM) functions in forward masking (0-ms masker-signal delay) were measured for normally hearing (NH) and hearing-impaired (HI) listeners using as maskers complex tones (harmonies 1-40, 100-Hz fundamental frequency) with components starting in cosine or random phase, and on-frequency sinusoids. The signal was a 20-ms sinusoid, usually with a frequency of I or 2 kHz. It is argued that differences in the slopes of the GOM functions for the random- and cosine-phase maskers provide a measure of the strength of compression in the cochlea. For the NH listeners and some of the HI listeners, the slopes were significantly greater for the random-than for the cosine-phase maskers, and for these listeners the slopes for the complex-tone maskers were less than for the sinusoidal maskers. For the remaining HI listeners, the slopes of the GOM functions were similar for all masker types. It is argued that these listeners had almost complete loss of cochlear compression. The GOM functions for the sinusoidal maskers had slopes between 0.45 and 0.78 and were typically in the range 0.6-0.7. The finding of slopes below one for listeners in whom cochlear compression was probably absent is not consistent with linear-integrator models of forward masking. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
RP Stainsby, TH (reprint author), Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England.
EM ths22@cam.ac.uk
RI Moore, Brian/I-5541-2012
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NR 48
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 38
EP 49
DI 10.1016/j.heares.2006.12.003
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000004
PM 17293068
ER
PT J
AU Harding, GW
Bohne, BA
AF Harding, Gary W.
Bohne, Barbara A.
TI Distribution of focal lesions in the chinchilla organ of Corti following
exposure to a 4-kHz or a 0.5-kHz octave band of noise
SO HEARING RESEARCH
LA English
DT Article
DE noise; organ of Corti; focal lesions; chinchilla
ID THRESHOLD SHIFTS; RETICULAR LAMINA; FREE-RADICALS; COCHLEA; DAMAGE;
DEGENERATION; VIBRATION; TEMPORARY; HEARING; LEVEL
AB An octave band of noise (OBN) delivers fairly uniform acoustic energy over a specific range of frequencies. Above and below this range, energy is at least 30 dB SPL less than that within the OBN. When the ear is exposed to an OBN, hair-cell loss often occurs outside the octave band. The frequency location of hair-cell loss is evident when the percent distance from the apex of focal lesions is analyzed. Focal lesions involve substantial loss of outer hair cells (OHCs) only, inner hair cells (IHCs) only, or both OHCs and IHCs (i.e., combined lesions) in a specific region of the organ of Corti (OC). Data sets were assembled from our permanent collection of noise-exposed chinchillas as follows: (1) the sum of exposure duration and recovery time was less than or equal to I I d; (2) the exposure level was less than or equal to 108 dB SPL; and (3) focal lesions were less than 1.5 turn in length. The data sets included a variety of exposures ranging from high-level, short duration to moderate-level, moderate duration. The center of each focal lesion was expressed as percent distance from the OC apex. Means, standard deviations and medians were calculated for focal-lesion size resulting from exposure to a 4-kHz or a 0.5-kHz OBN. Histograms were then constructed from the percent-location data using 2.0% bins. For the 4-kHz OBN, 5% of the lesions were in the apical half of the OC and 95% were in the basal half. The mean lesion size was 1.68% of total OC length for OHC and combined focal lesions and 0.42% for IHC focal lesions. Most OHC and combined lesions occurred in the 5-7-kHz region, at and just above the upper edge of the OBN. Clusters of lesions were also found around 8 and 12 kHz. A cluster was present at and just below the lower edge of the OBN, as well as another in the 1.5-kHz region. For the 0.5-kHz OBN, 34% of the lesions were in the apical half of the OC and 66% were in the basal half. The mean lesion size was 0.93% for OHC and combined focal lesions and 0.32% for IHC focal lesions. OHC and combined focal-lesion distribution showed clusters at 0.25, 0.75 and 1.5 kHz in the apical half of the OC. In the basal half, the distribution of focal lesions was similar to that seen with the 4-kHz OBN (r = 0.54). With both OBNs, most IHC focal lesions occurred in the basal half of the OC. High resolution power spectrum analysis of each OBN and non-invasive tests for harmonics and distortion products in a chinchilla were performed to look for exposure energy above and below the OBN. No energy was found that could explain the OC damage. (c) 2007 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Harding, GW (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, Box 8115,660 S Euclid Ave, St Louis, MO 63110 USA.
EM hardingg@ent.wustl.edu
RI Bohne, Barbara/A-9113-2008
OI Bohne, Barbara/0000-0003-3874-7620
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NR 34
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 50
EP 59
DI 10.1016/j.heares.2006.12.012
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000005
PM 17291699
ER
PT J
AU Coco, A
Epp, SB
Fallon, JB
Xu, J
Millard, RE
Shepherd, RK
AF Coco, Anne
Epp, Stephanie B.
Fallon, James B.
Xu, Jin
Millard, Rodney E.
Shepherd, Robert K.
TI Does cochlear implantation and electrical stimulation affect residual
hair cells and spiral ganglion neurons?
SO HEARING RESEARCH
LA English
DT Article
DE neural degeneration; auditory nerve; deafness; electrical stimulation;
cochlear implant; electric acoustic stimulation
ID SENSORINEURAL HEARING-LOSS; DEAFENED GUINEA-PIG; AUDITORY-NERVE;
ACOUSTIC STIMULATION; INNER-EAR; SURVIVAL; CATS; DEPOLARIZATION;
DEGENERATION; PATHOLOGY
AB Increasing numbers of cochlear implant subjects have some level of residual hearing at the time of implantation. The present study examined whether (i) hair cells that have survived one pathological insult (aminoglycoside deafening), can survive and function following long-term cochlear implantation and electrical stimulation (ES); and (ii) chronic ES in these cochleae results in greater trophic support of spiral ganglion neurons (SGNs) compared with cochleae devoid of hair cells. Eight cats, with either partial (n = 4) or severe (n = 4) sensorineural hearing loss, were bilaterally implanted with scala tympani electrode arrays 2 months after deafening, and received unilateral ES using charge balanced biphasic current pulses for periods of up to 235 days. Frequency-specific compound action potentials and click-evoked auditory brainstem responses (ABRs) were recorded periodically to monitor the residual acoustic hearing. Electrically evoked ABRs (EABRs) were recorded to confirm the stimulus levels were 3-6 dB above the EABR threshold. On completion of the ES program the cochleae were examined histologically. Partially deafened animals showed no significant increase in acoustic thresholds over the implantation period. Moreover, chronic ES of an electrode array located in the base of the cochlea did not adversely affect hair cells in the middle or apical turns. There was evidence of a small but statistically significant rescue of SGNs in the middle and apical turns of stimulated cochleae in animals with partial hearing. Chronic ES did not, however, prevent a reduction in SGN density for the severely deaf cohort, although SGNs adjacent to the stimulating electrodes did exhibit a significant increase in soma area (P < 0.01). In sum, chronic ES in partial hearing animals does not adversely affect functioning residual hair cells apical to the electrode array. Moreover, while there is an increase in the soma area of SGNs close to the stimulating electrodes in severely deaf cochleae, this trophic effect does not result in increased SGN survival. (c) 2006 Elsevier B.V. All rights reserved.
C1 Bion Ear Inst, Melbourne, Vic 3002, Australia.
Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
Royal Victorian Eye & Ear Hosp, Melbourne, Vic 3002, Australia.
RP Shepherd, RK (reprint author), Bion Ear Inst, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM rshepherd@bionicear.org
RI Fallon, James/B-5211-2012; Shepherd, Robert/I-6276-2012; Fallon,
James/B-6383-2014
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NR 52
TC 53
Z9 56
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 60
EP 70
DI 10.1016/j.heares.2006.12.004
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000006
PM 17258411
ER
PT J
AU Blauwkamp, MN
Beyer, LA
Kabara, L
Takemura, K
Buck, T
King, WM
Dolan, DF
Barald, KF
Raphael, Y
Koenig, RJ
AF Blauwkamp, Marsha N.
Beyer, Lisa A.
Kabara, Lisa
Takemura, Keiji
Buck, Timothy
King, W. M.
Dolan, David F.
Barald, Kate F.
Raphael, Yehoash
Koenig, Ronald J.
TI The role of bone morphogenetic protein 4 in inner ear development and
function
SO HEARING RESEARCH
LA English
DT Article
DE hair cells; neuronal processes; stereocilia; semicircular canals; mouse;
vestibulo-collic reflex (VCR); auditory brainstem response (ABR)
ID BONE-MORPHOGENETIC PROTEIN-4; HAIR-CELL STEREOCILIA; SENSORY EPITHELIA;
NERVOUS-SYSTEM; DEAFNESS DFNB3; MUTANT MICE; MYOSIN XV; NULL MICE;
MOUSE; GENERATION
AB Bone Morphogenetic Protein 4 (BMP4) is a member of the TGF-beta superfamily and is known to be important for the normal development of many tissues and organs, including the inner ear. Bmp4 homozygous null mice die as embryos, but Bmp4 heterozygous null (Bmp4(+'-)) mice are viable and some adults exhibit a circling phenotype, suggestive of an inner ear defect. To understand the role of BMP4 in inner ear development and function, we have begun to study C57BL/6 Bmp4(+/-) mice. Quantitative testing of the vestibulocollic reflex, which helps maintain head stability, demonstrated that Bmp4(+/-) mice that exhibit circling behavior have a poor response in the yaw axis, consistent with semicircular canal dysfunction. Although the hair cells of the ampullae were grossly normal, the stereocilia were greatly reduced in number. Auditory brainstem responses showed that Bmp4(+/-) mice have elevated hearing thresholds and immunohistochemical staining demonstrated decreased numbers of neuronal processes in the organ of Corti. Thus Bmp4(+/-) mice have structural and functional deficits in the inner ear. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Mol & Cellular Biol Program, Ann Arbor, MI 48109 USA.
Univ Michigan, Dept Internal Med, Div Endocrinol Diabet & Metab, Ann Arbor, MI 48109 USA.
Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA.
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA.
Kresge Hearing Res Inst, Dept Otolaryngol, Ann Arbor, MI 48106 USA.
RP Blauwkamp, MN (reprint author), Univ Michigan, Mol & Cellular Biol Program, 2966 Taubman Med Lib, Ann Arbor, MI 48109 USA.
EM mousman@med.umich.edu; lbeyer@umich.edu; lkabara@umich.edu;
takemura@umich.edu; bucktimo@umich.edu; wmking@umich.edu;
ddolan@umich.edu; kfbarald@umich.edu; yoash@umich.edu; rkoenig@umich.edu
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NR 43
TC 15
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 71
EP 79
DI 10.1016/j.heares.2006.12.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000007
PM 17275231
ER
PT J
AU Kulesza, RJ
AF Kulesza, Randy J., Jr.
TI Cyto architecture of the human superior olivary complex: Medial and
lateral superior olive
SO HEARING RESEARCH
LA English
DT Article
DE auditory; hearing; stereology; brainstem
ID INTERAURAL TIME SENSITIVITY; CALCIUM-BINDING PROTEINS; AUDITORY
BRAIN-STEM; INFERIOR COLLICULUS; SOUND LOCALIZATION; COCHLEAR NUCLEUS;
TRAPEZOID BODY; FINE-STRUCTURE; TONAL STIMULI; GUINEA-PIG
AB The superior olivary complex is a group of brainstem nuclei involved in hearing and includes the medial superior olive (MSO) and the lateral superior olive (LSO), surrounded by periolivary cell groups. The structure and functional roles of the MSO and LSO have been the subject of many investigations in laboratory animals and it has largely been assumed that these findings are directly transferable to humans. However, little is known conclusively regarding the detailed organization of the human superior olivary complex. The goal of this study is to provide a detailed analysis of the cytoarchitecture of the human MSO and LSO. Results from the examination of eight human brainstems confirm the existence of a conserved MSO and provide evidence of a prominent and highly ordered LSO. Unbiased stereological estimates of neuronal number indicate approximately 15,500 neurons in the MSO and 5600 neurons in the LSO. Additionally, a three-dimensional model of the MSO and LSO was constructed and provides evidence that the human LSO is composed of medial and lateral segments. Finally, an analysis of neuronal morphology, in Nisst stained and Golgi impregnated tissue, provides evidence of multiple neuronal classes within each nucleus and further that these neurons demonstrate a precise geometric arrangement (depending on the nucleus) that is suggestive of isofrequency laminae. (c) 2006 Elsevier B.V. All rights reserved.
C1 Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA 16509 USA.
RP Kulesza, RJ (reprint author), Lake Erie Coll Osteopath Med, Auditory Res Ctr, 1858 W Grandview Blvd, Erie, PA 16509 USA.
EM rkulesza@lecom.edu
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NR 50
TC 25
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 80
EP 90
DI 10.1016/j.heares.2006.12.006
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000008
PM 17250984
ER
PT J
AU Junius, D
Riedel, H
Kollmeier, B
AF Junius, Dirk
Riedel, Helmut
Kollmeier, Birger
TI The influence of externalization and spatial cues on the generation of
auditory brainstem responses and middle latency responses
SO HEARING RESEARCH
LA English
DT Article
DE auditory brainstem response; middle latency response; binaural
difference potential; interaural level difference; interaural time
difference; virtual acoustics; externalization
ID INTERAURAL TIME DIFFERENCES; BINAURAL INTERACTION COMPONENT;
EVOKED-POTENTIALS; SOUND LOCALIZATION; CORTICAL MECHANISMS; ELEVATION
CUES; LATERALIZATION; CORTEX; INTENSITY; FREQUENCY
AB The effect of externalization and spatial cues on the generation of auditory brainstem responses (ABRs) and middle latency responses (MLRs) was investigated in this study. Most previous evoked potential studies used click stimuli with variations of interaural time (ITDs) and interaural level differences (ILDs) which merely led to a lateralization of sound inside the subject's head. In contrast, in the present study potentials were elicited by a virtual acoustics stimulus paradigm with 'natural' spatial cues and compared to responses to a diotic, non-externalized reference stimulus. Spatial sound directions were situated on the horizontal plane (corresponding to variations in ITD, ILD, and spectral cues) or the midsagittal plane (variation of spectral cues only). An optimized chirp was used which had proven to be advantageous over the click since it compensates for basilar membrane dispersion. ABRs and MLRs were recorded from 32 scalp electrodes and both binaural potentials (B) and binaural difference potentials (BD, i.e., the difference between binaural and summed monaural responses) were investigated. The amplitudes of B and BD to spatial stimuli were not higher than those to the diotic reference. ABR amplitudes decreased and latencies increased with increasing laterality of the sound source. A rotating dipole source exhibited characteristic patterns in dependence on the stimulus laterality. For the MLR data, stimulus laterality was reflected in the latency of component N.. In addition, dipole source analysis revealed a systematic magnitude increase for the dipole contralateral to the azimuthal position of the sound source. For the variation of elevation, the right dipole source showed a stronger activation for stimuli away from the horizontal plane. The results indicate that at the level of the brainstem and primary auditory cortex binaural interaction is mostly affected by interaural cues (ITD, ILD). Potentials evoked by stimuli with natural combinations of ITD, ILD, and spectral cues were not larger than those elicited by diotic chirps. (c) 2007 Elsevier B.V. All rights reserved.
C1 Carl von Ossietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
RP Junius, D (reprint author), Carl von Ossietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
EM djunius@uni-oldenburg.de
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NR 51
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 91
EP 104
DI 10.1016/j.heares.2006.12.008
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000009
PM 17270375
ER
PT J
AU Stenfelt, S
AF Stenfelt, Stefan
TI Simultaneous cancellation of air and bone conduction tones at two
frequencies: Extension of the famous experiment by von Bekesy
SO HEARING RESEARCH
LA English
DT Article
DE bone conduction; cancellation experiment; basilar membrane stimulation
ID SOUND
AB Cancellation experiments between air conduction (AC) and bone conduction (BC) tones were conducted at two frequencies (0.7 and 1.1 kHz) and three levels (40, 50, and 60 dB HL) in three subjects. The tests were divided into three categories: (1) single tone cancellation, (2) simultaneous cancellation of two tones, and (3) cancellation of one tone while a disturbing tone was present. In total, each subject performed twelve cancellation tasks. The hypothesis is that the AC and BC sound transmission behaves as linear systems and they both excite the basilar membrane in the cochlea similarly. The cancellation results are presented as the deviations from this hypothesis; except for a few larger deviations, the intrasubject deviations were generally less than 0.5 dB and 5 degrees. The results from all three test categories indicate that the hypothesis of linear transmission systems and similarity of cochlear stimulation by AC and BC holds. However, due to the subjects' limited ability to conduct optimal cancellation and to imperfect methodology and equipment, the small deviations from perfectly linear cancellation that were observed do neither conclusively prove nor refute the possibility of small differences in the cochlear processing of AC and BC sound. Nonetheless, it is clear that if such differences in the processing of the two stimuli exist, they are small in magnitude. (c) 2006 Elsevier B.V. All rights reserved.
C1 Linkoping Univ Hosp, Div Tech Audiol, Dept Neurosci & Locomot, SE-58185 Linkoping, Sweden.
RP Stenfelt, S (reprint author), Linkoping Univ Hosp, Div Tech Audiol, Dept Neurosci & Locomot, SE-58185 Linkoping, Sweden.
EM stefan.stenfelt@inr.liu.se
RI Stenfelt, Stefan/J-9363-2013
OI Stenfelt, Stefan/0000-0003-3350-8997
CR [Anonymous], 1994, 3893 ISO
[Anonymous], 1998, 3891 ISO
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NR 19
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 105
EP 116
DI 10.1016/j.heares.2006.12.009
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000010
PM 17270374
ER
PT J
AU Sussman, E
Wong, R
Horvath, J
Winkler, I
Wang, W
AF Sussman, E.
Wong, R.
Horvath, J.
Winkler, I.
Wang, W.
TI The development of the perceptual organization of sound by frequency
separation in 5-11-year-old children
SO HEARING RESEARCH
LA English
DT Article
DE auditory stream segregation; frequency discrimination; children;
development; perception
ID AUDITORY STREAM SEGREGATION; TONE SEQUENCES; SCENE ANALYSIS; INFANTS;
CORTEX; ADULTS; DISCRIMINATION; SENSITIVITY; INTEGRATION; THRESHOLDS
AB The analysis of the auditory scene begins from the moment we hear sounds, making it possible for the infant to distinguish the mother's voice from other sounds in the environment. The purpose of the study was to determine, in two experiments, whether the frequency separation threshold, at which the perception of a mixture of sounds turns from being perceived as one stream to two streams, differs between two groups of school-aged children (ages 5-8 and 9-11 years) and adults. The results show a developmental course for the perception of auditory streams that is not simply dependent upon frequency discrimination. This suggests that maturation of the stream segregation process follows a longer developmental course than maturation of simple feature discrimination. The data indicate that the ability to hear distinct sound streams in the environment takes time to develop and becomes sharpened with experience and maturity. (c) 2007 Elsevier B.V. All rights reserved.
C1 Albert Einstein Coll Med, Dept Neurosci, Kennedy Ctr, Bronx, NY 10461 USA.
Albert Einstein Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Kennedy Ctr, Bronx, NY 10461 USA.
Hungarian Acad Sci, Inst Psychol, Budapest, Hungary.
Univ Helsinki, Cognit Brain Res Unit, Helsinki, Finland.
CUNY, Grad Ctr, Dept Speech & Hearing Sci, New York, NY 10021 USA.
RP Sussman, E (reprint author), Albert Einstein Coll Med, Dept Neurosci, Kennedy Ctr, Room 925,1410 Pelham Pkwy S, Bronx, NY 10461 USA.
EM esussman@aecom.yu.edu
RI Winkler, Istvan/A-7659-2008; Horvath, Janos/B-6477-2012
OI Winkler, Istvan/0000-0002-3344-6151; Horvath, Janos/0000-0003-0147-4518
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NR 33
TC 25
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 117
EP 127
DI 10.1016/j.heares.2006.12.013
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000011
PM 17300890
ER
PT J
AU Harding, GW
Bohne, BA
Lee, SC
Salt, AN
AF Harding, Gary W.
Bohne, Barbara A.
Lee, Steve C.
Salt, Alec N.
TI Effect of infrasound on cochlear damage from exposure to a 4 kHz octave
band of noise
SO HEARING RESEARCH
LA English
DT Article
DE infrasound; noise; histopathology; ABR; DPOAE; chinchilla
ID ABR THRESHOLD SHIFTS; DPOAE LEVEL SHIFTS; HISTOPATHOLOGICAL DAMAGE;
CHINCHILLA-COCHLEA; TYMPANIC-MEMBRANE; MIDDLE-EAR; CELL LOSS; TEMPORARY;
MICROSCOPY
AB Infrasound (i.e., < 20Hz for humans; < 100 Hz for chinchillas) is not audible, but exposure to high-levels of infrasound will produce large movements of cochlear fluids. We speculated that high-level infrasound might bias the basilar membrane and perhaps be able to minimize noise-induced hearing loss. Chinchillas were simultaneously exposed to a 30 Hz tone at 100dB SPL and a 4kHz OBN at either 108 dB SPL for 1.75 h or 86 dB SPL for 24 h. For each animal, the tympanic membrane (TM) in one car was perforated (similar to 1 mm(2)) prior to exposure to attenuate infrasound transmission to that cochlea by about 50 dB SPL. Controls included animals that were exposed to the infrasound only or the 4kHz OBN only. ABR threshold shifts (TSs) and DPOAE level shifts (LSs) were determined pre- and post-TM-perforation and immediately post-exposure, just before cochlear fixation. The cochleae were dehydrated, embedded in plastic, and dissected into flat preparations of the organ of Corti (OC). Each dissected segment was evaluated for losses of inner hair cells (IHCs) and outer hair cells (OHCs). For each chinchilla, the magnitude and pattern of functional and hair cell losses were compared between their right and left cochleae. The TM perforation produced no ABR TS across frequency but did produce a 10-21 dB DPOAE LS from 0.6 to 2 kHz. The infrasound exposure alone resulted in a 10-20 dB ABR TS at and below 2 kHz, no DPOAE LS and no IHC or OHC losses. Exposure to the 4 kHz OBN alone at 108 dB produced a 10-50 dB ABR TS for 0.5-12 kHz, a 10-60 dB DPOAE LS for 0.6-16 kHz and severe OHC loss in the middle of the first turn. When infrasound was present during exposure to the 4 kHz OBN at 108 dB, the functional losses and OHC losses extended much further toward the apical and basal tips of the OC than in cochleae exposed to the 4 kHz OBN alone. Exposure to only the 4 kHz OBN at 86 dB produces a 10-40 dB ABR TS for 3-12 kHz and 10-30 dB DPOAE LS for 3-8 kHz but little or no OHC loss in the middle of the first turn. No differences were found in the functional and hair-cell losses from exposure to the 4 kHz OBN at 86 dB in the presence or absence of infrasound. We hypothesize that exposure to infrasound and an intense 4 kHz OBN increases cochlear damage because the large fluid movements from infrasound cause more intermixing of cochlear fluids through the damaged reticular lamina. Simultaneous infrasound and a moderate 4 kHz OBN did not increase cochlear damage because the reticular lamina rarely breaks down during this moderate level exposure. (c) 2007 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Harding, GW (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
EM hardingg@ent.wustl.edu
RI Bohne, Barbara/A-9113-2008
OI Bohne, Barbara/0000-0003-3874-7620
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NR 28
TC 4
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2007
VL 225
IS 1-2
BP 128
EP 138
DI 10.1016/j.heares.2007.01.016
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 149HE
UT WOS:000245137000012
PM 17300889
ER
PT J
AU Shi, XR
Nuttall, AL
AF Shi, Xiaorui
Nuttall, Alfred L.
TI Expression of adhesion molecular proteins in the cochlear lateral wall
of normal and PARP-1 mutant mice
SO HEARING RESEARCH
LA English
DT Article
DE ICAM-1; PECAM-1; P-sclectin; leukocyte emigration; spiral ligament;
stria vascularis
ID POLY(ADP-RIBOSE) POLYMERASE; BLOOD-FLOW; REPERFUSION INJURY; STRIA
VASCULARIS; ACOUSTIC TRAUMA; CELL INJURY; LOUD SOUND; E-SELECTIN;
INNER-EAR; KAPPA-B
AB Sound can damage peripheral cochlear function through a number of mechanisms, and emerging evidence suggests that inflammation may be one of them. Using immunohistochemistry and poly (ADP-ribose) polymerase-1 (PARP-1) mutant mice, we tested whether PARP-1 contributes to loud-sound induced cochlear lateral wall damage by triggering inflammatory effects, including upregulating intercellular adhesion molecule-1 (ICAM-1), P-selectin and platelet-endothelial cell-adhesion molecule-1 (PECAM-1). In control conditions, we found that there was no detectable poly-ADP-ribose (PAR) in the marginal cells and microvessels. ICAM-1 was expressed only at low levels in the vessels of the stria vascularis and the spiral ligament. P-selectin and PECAM-1 were barely detected and only in the vessels of the spiral ligament. Following loud-sound exposure, PAR was detected in numbers of marginal cells and some vessels of the spiral ligament. Also, an elevated expression of ICAM-1 was demonstrated in some vessels of the stria vascularis and spiral ligament. Increased expression of P-selectin and PECAM-1 were mainly located in the vessels of the spiral ligament, while increased populations of non-migrated and migrated leukocytes were observed in the area of the spiral ligament. However, neither increased expression of adhesion proteins nor increased population of leukocytes, were observed in the PARP-1 knockout mouse. We thus conclude that loud-sound stress activates the expression of adhesion molecular proteins in the lateral wall and that PARP-1 modulates inflammation-linked protein expression and leukocyte migration. (c) 2006 Elsevier B.V. All rights reserved.
C1 Oregon Hlth Sci Univ, Dept Otolaryngol & Head & Neck Surg, Oregon Hearing Res Ctr NRC04, Portland, OR 97239 USA.
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Shanghai Jiao Tong Univ, Renji Hosp, Dept Otolaryngol, Shanghai 200030, Peoples R China.
RP Nuttall, AL (reprint author), Oregon Hlth Sci Univ, Dept Otolaryngol & Head & Neck Surg, Oregon Hearing Res Ctr NRC04, 3181 SW Sam Jackson Pk Rd,NRC04, Portland, OR 97239 USA.
EM nuttall@ohsu.edu
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NR 51
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 1
EP 14
DI 10.1016/j.heares.2006.10.011
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300001
PM 17184942
ER
PT J
AU Coffin, AB
Dabdoub, A
Kelley, MW
Popper, AN
AF Coffin, Allison B.
Dabdoub, Alain
Kelley, Matthew W.
Popper, Arthur N.
TI Myosin VI and VIIa distribution among inner ear epithelia in diverse
fishes
SO HEARING RESEARCH
LA English
DT Article
DE teleost; hearing; hair cell; saccule; utricle; lagena; myosin
ID SENSORY HAIR-CELLS; NONSYNDROMIC HEARING-LOSS; SNELLS-WALTZER MICE;
UNCONVENTIONAL MYOSIN; HEREDITARY DEAFNESS; STRUCTURAL INTEGRITY;
CROSS-LINKS; MUTATIONS; STEREOCILIA; ZEBRAFISH
AB Unconventional myosins are critical motor proteins in the vertebrate inner ear. Mutations in any one of at least six different myosins can lead to human hereditary deafness, but the precise functions of these proteins in the ear are unknown. This study uses a comparative approach to better understand the role of myosins VI and VIIa in vertebrate ears by examining protein distribution for these two myosins in the ears of evolutionarily diverse fishes and the aquatic clawed toad Xenopus laevis. Both myosins are expressed in the inner ears of all species examined in this study. Myo7a localizes to hair cells, particularly the actin-rich hair bundle, in all species studied. Myo6 also localizes to hair cells, but its distribution differs between species and end organs. Myo6 is found in hair bundles of most fish and frog epithelia examined here but not in anterior and posterior utricular hair bundles of American shad. These results show that myo7a distribution is highly conserved in diverse vertebrates and suggest functional conservation as well. The finding of myo6 in fish and Xenopus hair bundles, however, suggests a novel role for this protein in anamniotic hair cells. The lack of myo6 in specific American shad utricular hair bundles indicates a unique quality of these cells among fishes, perhaps relating to ultrasound detection capability that is found in this species. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
Natl Inst Deafness & Other Commun Disorders, Sect Dev Neurosci, NIH, Bethesda, MD 20892 USA.
Univ Maryland, Neurosci & Cognit Sci Program, College Pk, MD 20742 USA.
Univ Maryland, Ctr Comparat & Evolutionary Biol Hearing, College Pk, MD 20742 USA.
RP Coffin, AB (reprint author), Queens Univ, Dept Biol, Kingston, ON K7L 3N6, Canada.
EM coffina@biology.queensu.ca; dabdouba@nidcd.nih.gov;
kelleymt@nidcd.nih.gov; apopper@umd.edu
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NR 74
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 15
EP 26
DI 10.1016/j.heares.2006.11.004
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300002
PM 17204383
ER
PT J
AU Skjonsberg, A
Halsey, K
Ulfendahl, M
Dolan, DF
AF Skjonsberg, Asa
Halsey, Karin
Ulfendahl, Mats
Dolan, David F.
TI Exploring efferent-mediated DPOAE adaptation in three different guinea
pig strains
SO HEARING RESEARCH
LA English
DT Article
DE hearing; heterozygotes; noise resistance; age; presbyacousis
ID PRODUCT OTOACOUSTIC EMISSIONS; INDUCED HEARING-LOSS; OLIVOCOCHLEAR
REFLEX; ACOUSTIC TRAUMA; MICE; AGE; SUSCEPTIBILITY; PROTECTION;
RESISTANCE; INJURY
AB The aims of this study were to explore the correlation between DPOAE adaptation magnitude in three different guinea pig strains to examine if the genetic component affects the DPOAE adaptation magnitude. It was also to investigate the correlation between strains with certain characteristics i.e. reduced susceptibility to noise, and early onset of age-dependent hearing loss and the DPOAE adaptation magnitude. The animals were anaesthetized and the 2f1 - f2 DPOAE (f1 = 8 kHz, and f2/f1 = 1.2) adaptation was established with a minimum of 144 combinations of f1;f2 where f1 was held fixed and f2 was varied in 1 dB or 0.4 dB steps. The DPOAE adaptation magnitude was defined as the difference between maximum positive level and the maximum negative level. ABRs were conducted at different age-groups (at 4, 6.3, and 12.5 kHz) to evaluate the progress of hearing thresholds by age. There was a significant difference between strains regarding the hearing loss at one year of age. There was no significant difference in DPOAE adaptation magnitude between strains included in this study and from this we conclude that the DPOAE adaptation magnitude is not a predictor for the susceptibility to noise trauma, or early onset of age-dependent hearing loss, using the methods described in this paper. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Stockholm, Karolinska Hosp, Karolinska Inst, Ctr Hearing & Commun Res,Dept Clin Neurosci, SE-17176 Stockholm, Sweden.
Univ Stockholm, Karolinska Hosp, Dept Otolaryngol, SE-17176 Stockholm, Sweden.
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
RP Skjonsberg, A (reprint author), Univ Stockholm, Karolinska Hosp, Karolinska Inst, Ctr Hearing & Commun Res,Dept Clin Neurosci, Bldg M1.00, SE-17176 Stockholm, Sweden.
EM asa.skjonsberg@ki.se; khalsey@umich.edu; mats.ulfendahl@ki.se;
ddolan@umich.edu
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NR 29
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 27
EP 33
DI 10.1016/j.heares.2006.11.008
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300003
PM 17224252
ER
PT J
AU Ohlemiller, KK
Gagnon, PM
AF Ohlemiller, Kevin K.
Gagnon, Patricia M.
TI Genetic dependence of cochlear cells and structures injured by noise
SO HEARING RESEARCH
LA English
DT Article
DE stria vascularis; spiral ligament; spiral limbus; endocochlear
potential; fibrocytes; C57BL/6; CBA/J; melanin
ID INDUCED HEARING-LOSS; PRODUCT OTOACOUSTIC EMISSIONS; PERMANENT THRESHOLD
SHIFT; SPONTANEOUSLY HYPERTENSIVE RATS; CHLOROQUINE-TREATED RED;
GUINEA-PIG COCHLEA; ACOUSTIC TRAUMA; STRIA-VASCULARIS; INNER-EAR; MOUSE
COCHLEA
AB The acute and permanent effects of a single damaging noise exposure were compared in CBA/J, C57BL/6 (B6), and closely related strains of mice. Two hours of broadband noise (4-45 kHz) at 110 dB SPL led to temporary reduction in the endocochlear potential (EP) of CBA/J and CBA/CaJ (CBA) mice and acute cellular changes in cochlear stria vascularis and spiral ligament. For the same exposure, 136 mice showed no EP reduction and little of the pathology seen in CBA. Eight weeks after exposure, all mice showed a normal EP, but only CBA mice showed injury and cell loss in cochlear lateral wall, despite the fact that B6 sustained larger permanent threshold shifts. Examination of noise injury in B6 congenics carrying alternate alleles of genes encoding otocadherin (Cdh23), agouti protein, and tyrosinase (albinism) indicated that none of these loci can account for the strain differences observed. Examination of CBAxB6 F1 mice and N2 backcross mice to B6 further indicated that susceptibility to noise-related EP reduction and associated cell pathology are inherited in an autosomal dominant manner, and are established by one or a few large effect quantitative trait loci. Findings support a common genetic basis for an entire constellation of noise-related cochlear pathologies in cochlear lateral wall and spiral limbus. Even within species, cellular targets of acute and permanent cochlear noise injury may vary with genetic makeup. (c) 2006 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Ohlemiller, KK (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, 660 S Euclid Ave, St Louis, MO 63110 USA.
EM kohlemiller@wustl.edu
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NR 86
TC 29
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 34
EP 50
DI 10.1016/j.heares.2006.11.005
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300004
PM 17175124
ER
PT J
AU McCullough, BJ
Adams, JC
Shilling, DJ
Feeney, MP
Sie, KCY
Tempel, BL
AF McCullough, Brendan J.
Adams, Joe C.
Shilling, Dustin J.
Feeney, M. Patrick
Sie, Kathleen C. Y.
Tempel, Bruce L.
TI 3p-syndrome defines a hearing loss locus in 3p25.3
SO HEARING RESEARCH
LA English
DT Article
DE 3p-syndrome.; hearing loss; ATP2B2; PMCA2; deafwaddler
ID ENDOLYMPHATIC SAC TUMORS; HAIR-CELL STEREOCILIA; HIPPEL-LINDAU-DISEASE;
CONNEXIN 26 GENE; DEAFWADDLER MICE; KNOCKOUT MICE; SHORT ARM; DELETION;
MUTATIONS; DEAFNESS
AB Deletions affecting the terminal end of chromosome 3p result in a characteristic set of clinical features termed 3p- syndrome. Bilateral, sensorineural hearing loss (SNHL) has been found in some but not all cases, suggesting the possibility that it is due to loss of a critical gene in band 3p25. To date, no genetic locus in this region has been shown to cause human hearing loss. However, the ATP2B2 gene is located in 3p25.3, and haploinsufficiency of the mouse homolog results in SNHL with similar severity. We compared auditory test results with fine deletion mapping in seven previously unreported 3p- syndrome patients and identified a 1.38 Mb region in 3p25.3 in which deletions were associated with moderate to severe, bilateral SNHL. This novel hearing loss locus contains 18 genes, including ATP2B2. ATP2B2 encodes the plasma membrane calcium pump PMCA2. We used immunohistochemistry in human cochlear sections to show that PMCA2 is located in the stereocilia of hair cells, suggesting its function in the auditory system is conserved between humans and mice. Although other genes in this region remain candidates, we conclude that haploinsufficiency of ATP2B2 is the most likely cause of SNHL in 3p- syndrome. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Washington, Sch Med, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
Univ Washington, Sch Med, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
Univ Washington, Sch Med, Grad Program Neurobiol & Behav, Seattle, WA 98195 USA.
Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02114 USA.
Childrens Hosp & Reg Med Ctr, Seattle, WA 98105 USA.
RP Tempel, BL (reprint author), Univ Washington, Sch Med, Virginia Merrill Bloedel Hearing Res Ctr, Box 357923, Seattle, WA 98195 USA.
EM brenmcc@u.washington.edu; Joe_Adams@meei.harvard.edu;
dustinj@u.washington.edu; pfeeney@u.washington.edu;
Kathleen.Sie@seattlechildrens.org; bltempel@u.washington.edu
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NR 39
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 51
EP 60
DI 10.1016/j.heares.2006.11.006
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300005
PM 17208398
ER
PT J
AU Pouyatos, B
Gearhart, C
Nelson-Miller, A
Fulton, S
Fechter, L
AF Pouyatos, Benoit
Gearhart, Caroline
Nelson-Miller, Alisa
Fulton, Sherry
Fechter, Laurence
TI Oxidative stress pathways in the potentiation of noise-induced hearing
loss by acrylonitrile
SO HEARING RESEARCH
LA English
DT Article
DE acrylonitrile; L-N acetylcysteine; sodium thiosulfate; 4-methylpyrazole;
noise; hearing loss; hair cell loss; ototoxicity; reactive oxygen
species; oxidative stress; glutathione; cyanide; superoxide dismutase
ID SUPEROXIDE-DISMUTASE; IMPULSE NOISE; COCHLEAR FUNCTION; CARBON-MONOXIDE;
FREE-RADICALS; GLUTATHIONE; PROTECTION; OXYGEN; SUSCEPTIBILITY; EXPOSURE
AB We hypothesize that the disruption of antioxidant defenses is a key mechanism whereby chemical contaminants can potentiate noise-induced hearing loss (NIHL). This hypothesis was tested using acrylonitrile (ACN), a widely used industrial chemical whose metabolism is associated with glutathione (GSH) depletion and cyanide (CN) generation. CN, in turn, can inhibit Cu/Zn superoxide dismutase (SOD). We have shown previously that ACN potentiates NIHL, even with noise exposure approaching permissible occupational levels. However, the relative involvement of GSH depletion and/or CN production in this potentiation is still unknown. In this study, we altered these metabolic pathways pharmacologically in order to further delineate the role of specific antioxidants in the protection of the cochlea. We investigated the effects of sodium thiosulfate (STS), a CN inhibitor, 4-methylpyrazole (4MP), a drug that blocks CN generation by competing with CYP2E1, and L-N-acetylcysteine (L-NAC), a pro-GSH drug, in order to distinguish between GSH depletion and CN production as the mechanism responsible for potentiation of NIHL by ACN. Long-Evans rats were exposed to an octave-band noise (97 dB SPL, 4 h/day, 5 days) and ACN (50 mg/kg). Separate pre-treatments with STS (150 mg/kg), 4MP (100 mg/kg) and L-NAC (4 x 400 mg/kg) all dramatically reduced blood CN levels, but Only L-NAC significantly protected GSH levels in both the liver and the cochlea. Concurrently, only L-NAC treatment decreased the auditory loss and hair cell loss resulting from ACN + noise, suggesting that GSH is involved in the protection of the cochlea against reactive oxygen species generated by moderate noise levels. On the other hand, CN does not seem to be involved in this potentiation. Published by Elsevier B.V.
C1 Jerry L Pettis Mem Vet Adm Med Ctr, Dept Vet Affairs Med Ctr, Loma Linda, CA 92357 USA.
RP Pouyatos, B (reprint author), Jerry L Pettis Mem Vet Adm Med Ctr, Dept Vet Affairs Med Ctr, 11201 Benton St, Loma Linda, CA 92357 USA.
EM benoit.pouyatos@med.va.gov
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NR 39
TC 12
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 61
EP 74
DI 10.1016/j.heares.2006.11.009
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300006
PM 17222524
ER
PT J
AU Luo, H
Boemio, A
Gordon, M
Poeppel, D
AF Luo, Huan
Boemio, Anthony
Gordon, Michael
Poeppel, David
TI The perception of FM sweeps by Chinese and English listeners
SO HEARING RESEARCH
LA English
DT Article
DE tone language; temporal threshold; FM identification; FM discrimination;
signal detection; bias; FM direction selectivity
ID PRIMARY AUDITORY-CORTEX; STEADY-STATE RESPONSES; TEMPORAL-ORDER
JUDGMENTS; FREQUENCY-MODULATION; LANGUAGE EXPERIENCE;
AMPLITUDE-MODULATION; SIGNAL-DETECTION; VISUAL-STIMULI; TONES;
DISCRIMINATION
AB Frequency-modulated (FM) signals are an integral acoustic component of ecologically natural sounds and are analyzed effectively in the auditory systems of humans and animals. Linearly frequency-modulated tone sweeps were used here to evaluate two questions. First, how rapid a sweep can listeners accurately perceive? Second, is there an effect of native language insofar as the language (phonology) is differentially associated with processing of FM signals? Speakers of English and Mandarin Chinese were tested to evaluate whether being a speaker of a tone language altered the perceptual identification of non-speech tone sweeps. In two psychophysical studies, we demonstrate that Chinese subjects perform better than English subjects in FM direction identification, but not in an FM discrimination task, in which English and Chinese speakers show similar detection thresholds of approximately 20 ms duration. We suggest that the better FM direction identification in Chinese subjects is related to their experience with FM direction analysis in the tone-language environment, even though supra-segmental tonal variation occurs over a longer time scale. Furthermore, the observed common discrimination temporal threshold across two language groups supports the conjecture that processing auditory signals at durations of similar to 20 ms constitutes a fundamental auditory perceptual threshold. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Maryland, Neurosci & Cognit Sci Program, College Pk, MD 20742 USA.
Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
Univ Maryland, Dept Linguist, College Pk, MD 20742 USA.
RP Luo, H (reprint author), Univ Maryland, Neurosci & Cognit Sci Program, 1401 Marine Mount Hall, College Pk, MD 20742 USA.
EM luohuan@gmail.com
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NR 55
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 75
EP 83
DI 10.1016/j.heares.2006.11.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300007
PM 17207949
ER
PT J
AU Sellick, PM
Kirk, DL
Patuzzi, R
Robertson, D
AF Sellick, P. M.
Kirk, D. L.
Patuzzi, R.
Robertson, D.
TI Does BAPTA leave outer hair cell transduction channels closed?
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; endolymphatic potential; cochlear microphonic; outer hair
cells; BAPTA; tip links; stereocilia; mechanotransduction
ID TIP LINKS; MECHANOELECTRICAL TRANSDUCTION; MECHANICAL TRANSDUCTION;
COCHLEAR POTENTIALS; 4-AMINOPYRIDINE; STEREOCILIA; EMISSIONS
AB The calcium chelator BAPTA was iontophoresed into the scala media of the second turn of the guinea pig cochlea. This produced a reduction in low frequency cochlear microphonic (CM) measured in scala media and an elevation of the cochlear action potential (CAP) threshold that lasted for the duration of the experiment. Using two pipettes, one filled with KCl and the other KCl and BAPTA (50, 20 and 5 mM) it was possible to observe the effect of passing current through one electrode while measuring the endolymphatic, potential (EP) with the other. The results demonstrated that current passed via the BAPTA pipette caused a sustained increase in EP of 8.2, 12.9 and 7.8 mV in the three animals used. This increase coincided with the decrease in low frequency CM that indicated a causal connection between the two. In a second series of experiments, pipettes with larger tips were inserted into scala media in the first cochlear turn and BAPTA was allowed to diffuse from the pipette. The results confirmed the relationship between EP increase and the fall of scala media CM. One interpretation of these results is that lowering the Ca2+ concentration of endolymph with BAPTA inhibits mechano-electrical transduction in outer hair cells (OHCs) and leaves the hair cell transduction channels in a closed state, thus increasing the resistance across OHCs and increasing the EP. These findings are consistent with a model of hair cell transduction in which tension on stereo cilia opens the transduction channels. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Western Australia, Sch Biomed Biomol & Chem Sci, Auditory Lab, Discipline Physiol, Nedlands, WA 6009, Australia.
RP Sellick, PM (reprint author), Univ Western Australia, Sch Biomed Biomol & Chem Sci, Auditory Lab, Discipline Physiol, Nedlands, WA 6009, Australia.
EM psellick@cyllene.uwa.edu.au
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NR 23
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 84
EP 92
DI 10.1016/j.heares.2006.11.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300008
PM 17222995
ER
PT J
AU Vigneault-MacLean, BK
Hall, SE
Phillips, DP
AF Vigneault-MacLean, Bronwyn K.
Hall, Susan E.
Phillips, Dennis P.
TI The effects of lateralized adaptors on lateral position judgements of
tones within and across frequency channels
SO HEARING RESEARCH
LA English
DT Article
DE sound lateralization; hemifield model; psychophysics; interaural time
difference; selective adaptation
ID PRIMARY AUDITORY-CORTEX; SOUND-LOCALIZATION; CAT; NEURONS; SENSITIVITY;
LOCATION; LEVEL; NOISE; SPACE; TIME
AB Two experiments examined the effect of highly lateralized adaptor tone pulses on the perceived intracranial location of subsequent test tones. In Experiment 1, adaptor tones of each of two frequencies, highly lateralized to opposite sides by a quarter-period interaural time difference (ITD), were found to shift the perceived intracranial location of test tones of each adaptor frequency away from the side of the adaptor. The shift in perceived location was seen for all test tone ITDs with the same sign as the adaptor tone, and sometimes extended to include test tones with small ITDs favoring the opposite ear. The generality of the effect across test tone ITDs of the same sign as the adaptor suggests that the human auditory lateralization system is built of two (left, right) hemifield-tuned azimuthal channels, and that perceived lateral location depends on the relative outputs of those two channels. In Experiment 2, the perceived location of test tones lateralized by ITD was studied in the same listeners at each of the same two frequencies, but after selective adaptation with tone pulses of only one frequency and laterality. The perceived lateral position of test tones with the same frequency as that of the adaptor underwent the same changes as seen in Experiment 1. The perceived lateral position of test tones of the nonadapted frequency usually shifted weakly in the opposite direction, i.e., in the direction expected if the second adaptor from Experiment 1 had actually been present. These data have implications both for the processes mediating selective adaptation using contingent stimuli, and for the azimuthal tuning of auditory spatial channels in man. (c) 2006 Elsevier B.V. All rights reserved.
C1 Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada.
RP Phillips, DP (reprint author), Dalhousie Univ, Dept Psychol, Hearing Res Lab, 1355 Oxford St, Halifax, NS B3H 4J1, Canada.
EM dennis.phillips@dal.ca
RI Phillips, Dennis/A-6496-2011
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NR 25
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 93
EP 100
DI 10.1016/j.heares.2006.12.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300009
PM 17223297
ER
PT J
AU Gleich, O
Kittel, MC
Kiump, GM
Strutz, J
AF Gleich, Otto
Kittel, Malte C.
Kiump, Georg M.
Strutz, Juergen
TI Temporal integration in the gerbil: The effects of age, hearing loss and
temporally unmodulated and modulated speech-like masker noises
SO HEARING RESEARCH
LA English
DT Article
DE presbyacusis; psychoacoustic testing; psychometric function;
simultaneous masking; response latency; comodulation masking release
ID AUDITORY-NERVE FIBERS; COMODULATION MASKING RELEASE; SIGNAL DURATION;
GUINEA-PIG; MERIONES-UNGUICULATUS; MONGOLIAN GERBIL; COCHLEAR NUCLEUS;
PURE-TONES; CAT; THRESHOLDS
AB We characterized temporal integration for 2 kHz pure tones with durations between 10 and 1000 ms in young, normal hearing old and old gerbils with a small hearing loss. Thresholds determined in silence increased for durations below 300 ms and were on average more than 10 dB higher for the 10 ms signal than asymptotic thresholds for the long signals. The amount of temporal integration tended to be less in gerbils with hearing loss. Threshold determination was repeated in the same individuals in the presence of speech-like unmodulated and modulated masking noises. Threshold shift due to the maskers was inversely related to the threshold in silence resulting in a reduced inter-individual variability of thresholds in both masking conditions. Thresholds differed systematically between both masker types in a duration dependent fashion. For long signal durations (300 and 1000 ms) thresholds were on average 2 dB lower and for the 10 ms signal 1.9 dB higher in the presence of the modulated masker. These differences in threshold obtained with the two maskers were significant. One hypothesis is that long signals can be detected in the troughs of the modulated masker, while peaks interfere with the detection of short signals. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Regensburg, ENT Dept, D-93042 Regensburg, Germany.
Univ Oldenburg, Inst Biol & Umweltwissensch, AG Zoophysiol & Verhalten, D-26111 Oldenburg, Germany.
RP Gleich, O (reprint author), Univ Regensburg, ENT Dept, Franz Josef Str Allee 11, D-93042 Regensburg, Germany.
EM otto.gleich@klinik.uni-regensburg.de; Malte.Kittel@astrazeneca.com;
Georg.Klump@uni-oldenburg.de; juergen.strutz@klinik.uni-regensburg.de
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NR 55
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2007
VL 224
IS 1-2
BP 101
EP 114
DI 10.1016/j.heares.2006.12.002
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 139JE
UT WOS:000244427300010
PM 17223296
ER
PT J
AU Huang, J
Yang, ZG
Ping, JL
Liu, X
Wu, XH
Li, L
AF Huang, Juan
Yang, Zhigang
Ping, Junli
Liu, Xian
Wu, Xihong
Li, Liang
TI The influence of the perceptual or fear learning on rats' prepulse
inhibition induced by changes in the correlation between two spatially
separated noise sounds
SO HEARING RESEARCH
LA English
DT Article
DE acoustic startle; prepulse inhibition; sound correlation; fear
conditioning; perceptual learning
ID ACOUSTIC STARTLE RESPONSE; REFLEX MODIFICATION; ATTENTIONAL MODULATION;
GAP DETECTION; INFERIOR COLLICULUS; BACKGROUND-NOISE; TEMPORAL ACUITY;
ANIMAL-MODEL; DISCRIMINATION; EYEBLINK
AB Perceptually grouping a sound source with its reflections and separating them from irrelevant background noise sounds need computation of sound correlations and are critical for identifying and localizing the sound source in a complex acoustic environment. Using the prepulse inhibition of the acoustic startle reflex (ASR) as a measure, the present study investigated whether rats are able to detect correlation changes between sounds from different spatial locations. The results show that the rat's ASR amplitude was suppressed when the startle-eliciting stimulus was preceded by either an uncorrelated noise fragment or an anti-phase noise fragment that was embedded in two identical (correlated) but spatially separated noises. Suppression of the ASR amplitude increased as the duration of the noise fragment increased from 5 ms to 40 ms. The suppressive effect was also progressively enhanced after rats underwent successive testing sessions. Moreover, an enhanced suppression of the ASR amplitude was observed after rats were exposed to footshock that was precisely paired with a 100-ms correlation-change fragment. The results indicate that rats are able to detect the correlation change between sounds from two separated spatial locations, and the detection can be facilitated by both perceptual learning and emotional learning. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Toronto, Ctr Res Biol Commun Syst, Dept Psychol, Mississauga, ON L5L 1C6, Canada.
Peking Univ, Speech & Hearing Res Ctr, Natl Key Lab Machine Percept, Dept Psychol, Beijing 100871, Peoples R China.
RP Li, L (reprint author), Univ Toronto, Ctr Res Biol Commun Syst, Dept Psychol, Mississauga, ON L5L 1C6, Canada.
EM liangli@pku.edu.cn
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NR 52
TC 9
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 1
EP 10
DI 10.1016/j.heares.2006.09.012
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500001
PM 17098386
ER
PT J
AU Bielefeld, EC
Henderson, D
AF Bielefeld, Eric C.
Henderson, Donald
TI Influence of sympathetic fibers on noise-induced hearing loss in the
chinchilla
SO HEARING RESEARCH
LA English
DT Article
DE superior cervical ganglion; noise; DPOAE; cochlea; sympathetic
ID COCHLEAR BLOOD-FLOW; OTOACOUSTIC EMISSIONS; ACOUSTIC TRAUMA; CERVICAL
SYMPATHECTOMY; ADRENERGIC INNERVATION; THRESHOLD SHIFT; GUINEA-PIG; EAR;
STIMULATION; GANGLION
AB The influence of the sympathetic efferent fibers on cochlear susceptibility to noise-induced hearing loss is still an open question. In the current study, we explore the effects of unilateral and bilateral Superior Cervical Ganglion (SCG) ablation in the chinchilla on hearing loss from noise exposure, as measured with inferior colliculus (IC) evoked potentials, distortion product otoacoustic emissions (DPOAE), and outer hair cell (OHC) loss. The SCG was isolated at the level of the bifurcation of the carotid artery and removed unilaterally in 15 chinchillas. Another eight chinchillas underwent bilateral ablation. Twelve animals were employed as sham controls. Noise exposure was a 4 kHz octave band noise for I It at 110 dB SPL. Results showed improved recovery of DPOAE amplitudes after noise exposure in ears that underwent SCGectomy, as well as lower evoked potential threshold shifts relative to sham controls. Effects of SCGectomy on OHC loss were small. Results of the study suggest that sympathetic fibers do exert some influence on susceptibility to noise, but the influence may not be a major one. (c) 2006 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Bielefeld, EC (reprint author), SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM ecb2@buffalo.edu
RI Bielefeld, Eric/D-2015-2012
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NR 29
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 11
EP 19
DI 10.1016/j.heares.2006.09.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500002
PM 17092669
ER
PT J
AU Didyk, LA
Dirckx, JJJ
Bogdanov, VB
Lysenko, VA
Gorgo, YP
AF Didyk, L. A.
Dirckx, J. J. J.
Bogdanov, V. B.
Lysenko, V. A.
Gorgo, Yu. P.
TI The mechanical reaction of the pars flaccida of the eardrum to rapid air
pressure oscillations modeling different levels of atmospheric
disturbances
SO HEARING RESEARCH
LA English
DT Article
DE middle ear; tympanic membrane; pars flaccida; mechanical reactions;
rapid pressure fluctuations
ID MIDDLE-EAR PRESSURE; TYMPANIC MEMBRANE; GERBIL; SYSTEM
AB Atmospheric pressure fluctuations (APF) might induce mechanical effects in the pars flaccida (PF) of the eardrum. To clarify these effects, different kinds of pressure oscillations (PO), chosen within the range of naturally occurring APF, were applied to the middle ears (ME) of gerbils. The linear displacement of the PF during a PO in the ME was measured by laser interferometry. The compliance of the PF to PO was calculated as the ratio of the amplitude of a PF oscillation to the amplitude of a PO. The displacement of the PF traced the PO in the entire range of frequencies (from 10 mHz to 200 mHz) and amplitudes (from 10 Pa to 110 Pal applied to the ME. Moreover, the PF is found to be displaced by pressure pulses of a few pascals only using a PO with a complex shape. The differences found in the compliance of the PF due to PO with low (less than 20 Pal and high (more than 90 Pa) amplitude point out that the mechanism of pressure regulation in the ME through the mechanical reaction of the PF in gerbil ears is better adapted to ordinary levels of natural APF than to extraordinary levels. The implications of these findings for the physiology of the human ME with respect to adaptation to natural APF are discussed. (c) 2006 Elsevier B.V. All rights reserved.
C1 Natl Acad Sci Ukraine, Inst Phys, UA-03028 Kiev, Ukraine.
Univ Antwerp, Lab Biomed Phys, B-2020 Antwerp, Belgium.
Taras Shevchenko Natl Univ, Dept Biol, UA-01033 Kiev, Ukraine.
RP Didyk, LA (reprint author), Natl Acad Sci Ukraine, Inst Phys, Pr Nauki 46, UA-03028 Kiev, Ukraine.
EM didyk@iop.kiev.ua; Joris.Dirckx@ua.ac.be; vlabogd@yahoo.com;
lysenko_v@yahoo.com; yugorgo@ukr.net
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NR 32
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 20
EP 28
DI 10.1016/j.heares.2006.09.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500003
PM 17098387
ER
PT J
AU Santurette, S
Dau, T
AF Santurette, Sebastien
Dau, Torsten
TI Binaural pitch perception in normal-hearing and hearing-impaired
listeners
SO HEARING RESEARCH
LA English
DT Article
DE binaural pitch; hearing impairment; melody recognition; spectral and
temporal resolution; auditory modeling
ID AUDITORY FILTER SHAPES; DICHOTIC PITCHES; EDGE PITCH; LEVEL DIFFERENCES;
HUGGINS PITCH; GAP DETECTION; NOISE; SENSATION; DECAY; TIME
AB The effects of hearing impairment on the perception of binaural-pitch stimuli were investigated. Several experiments were performed with normal-hearing and hearing-impaired listeners, including detection and discrimination of binaural pitch, and melody recognition using different types of binaural pitches. For the normal-hearing listeners, all types of binaural pitches could be perceived immediately and were musical. The hearing-impaired listeners could be divided into three groups based on their results: (a) some perceived all types of binaural pitches, but with decreased salience or musicality compared to normal-hearing listeners; (b) some could only perceive the strongest pitch types; (c) some were unable to perceive any binaural pitch at all. The performance of the listeners was not correlated with audibility. Additional experiments investigated the correlation between performance in binaural-pitch perception and performance in measures of spectral and temporal resolution. Reduced frequency discrimination appeared to be linked to poorer melody recognition skills. Reduced frequency selectivity was also found to impede the perception of binaural-pitch stimuli. Overall, binaural-pitch stimuli might be very useful tools within clinical diagnostics for detecting specific deficiencies in the auditory system. (c) 2006 Elsevier B.V. All rights reserved.
C1 Tech Univ Denmark, Orsted DTU, Ctr Appl Hearing Res, DK-2800 Lyngby, Denmark.
RP Dau, T (reprint author), Tech Univ Denmark, Orsted DTU, Ctr Appl Hearing Res, DTU Bygning 352,Orsteda Plads, DK-2800 Lyngby, Denmark.
EM ses@oersted.dtu.dk; tda@oersted.dtu.dk
RI Santurette, Sebastien/B-6872-2009
OI Santurette, Sebastien/0000-0002-6868-5734
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NR 34
TC 22
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 29
EP 47
DI 10.1016/j.heares.2006.09.013
PG 19
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500004
PM 17107767
ER
PT J
AU Guiraud, J
Gallego, S
Arnold, L
Boyle, P
Truy, E
Collet, L
AF Guiraud, Jeanne
Gallego, Stephane
Arnold, Laure
Boyle, Patrick
Truy, Eric
Collet, Lionel
TI Effects of auditory pathway anatomy and deafness characteristics? (1):
On electrically evoked auditory brainstem responses
SO HEARING RESEARCH
LA English
DT Article
DE EABR latencies; tonotopy; cochlear implant; deafness characteristics
ID COCHLEAR IMPLANT USERS; SPEECH PROCESSING STRATEGIES; GUINEA-PIG;
ELECTRODE DISCRIMINATION; CURRENT DISTRIBUTIONS; CHANNEL INTERACTION;
OPERATING RANGES; DIFFERENT SITES; PITCH RANKING; CURRENT LEVEL
AB The purpose of this study was to distinguish the effects of different parameters on latencies of wave IIIe, wave Ve, and interpeak interval IIIe-Ve of electrical auditory brainstem responses (EABRs). EABRs were recorded from all the intra-cochlear electrodes in eight adult HiRes90K (R) cochlear implant users. The relationship between latencies and stimulation sites in the cochlea was characterized to assess activity along the auditory pathway. Audiograms before implantation, psychophysics at first fitting and duration of deafness were used to describe the influence of deafness on latencies. A decreasing baso-apical latency gradient was found for waves IIIe and Ve, while the interpeak interval IIIe-Ve remained the same along the electrode array. Electrical stimulation enabling to stimulate various parts of the cochlea at the same time, this could indicate an anatomical way of compensating for the delay the acoustic wave takes to reach the cochlea apex in a non-implanted ear. However, psychophysical levels were also found to increase at the cochlear base showing that the latency gradient could result from an increasing gradient of neural degeneration toward the base. Correlations of EABR latencies with psychophysics, audiometric data and duration of deafness show that factors linked to deafness have indeed an influence on EABR latencies. The possible explanations for the latency shift observed, whether they are anatomical and/or pathological, are exposed. (c) 2006 Elsevier B.V. All rights reserved.
C1 Edouard Herriot Univ Hosp, Dept Audiol & Otorhinolaryngol, F-69437 Lyon, France.
Univ Lyon 1, Neurosci & Sensorial Syst Lab, CNRS, UMR 5020, F-69003 Lyon, France.
Edouard Herriot Univ Hosp, Dept Otolaryngol Head & Neck Surg, F-69437 Lyon, France.
Dept Clin Res, Cambridge CB2 5LD, England.
RP Guiraud, J (reprint author), Edouard Herriot Univ Hosp, Dept Audiol & Otorhinolaryngol, 5 Pl Arsonval, F-69437 Lyon, France.
EM jeanne_guiraud@hotmail.com; sgallego@hotmail.fr; laurea@abionics.fr;
patrickb@abionics.fr; eric.truy@chu-lyon.fr; lionel.collet@chu-lyon.fr
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NR 82
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 48
EP 60
DI 10.1016/j.heares.2006.09.014
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500005
PM 17157463
ER
PT J
AU Bohne, BA
Harding, GW
Lee, SC
AF Bohne, Barbara A.
Harding, Gary W.
Lee, Steve C.
TI Death pathways in noise-damaged outer hair cells
SO HEARING RESEARCH
LA English
DT Article
DE cell-death pathways; noise damage; chinchilla; histopathology
ID CHINCHILLA COCHLEA; INTENSE NOISE; INDUCED APOPTOSIS; EXPOSURE;
MICROSCOPY; MORPHOLOGY; ONCOSIS; LENGTH; ORGAN; CORTI
AB Using morphological criteria, death pathways in outer hair cells (OHCs) were determined in chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of noise (OBN) centered at either 0.5 or 4-kHz. The specimens were part of our large collection of plastic-embedded flat preparations of chinchilla cochleae. Three death pathways were identified: (1) oncotic - swollen, pale-staining cell with a swollen nucleus, (2) apoptotic - shrunken, dark-staining cell with a pyknotic nucleus and (3) a newly defined third pathway - no basolateral plasma membrane but cellular debris arranged in the shape of an intact OHC with a nucleus deficient in nucleoplasm. To minimize the secondary loss of OHCs from the entrance of endolymph into the organ of Corti, the specimens used for quantitative analysis of death pathways had the following characteristics: (1) the level to which they were exposed was less than or equal to 95 dB SPL. (2) the exposure duration was 6-216 h, (3) fixation for microscopic examination took place in vivo 1-2 h post-exposure and (4) there were no focal OHC lesions in the organs of Corti. Fifty-eight noise-exposed cochleae met these criteria. In these specimens, degenerating and missing OHCs were classified as to which death pathway the cells had followed or were following. Nine non-noise-exposed cochleae were also evaluated for OHC death pathways. The number of OHCs following the third death pathway was significantly greater in the noise-exposed cochleae than the non-noise-exposed cochleae for total exposure energies greater than those produced by 75 dB SPL for 216 h to a 0.5-kHz OBN and 57 dB SPL for 48 h to a 4-kHz OBN. In cochleae exposed to either octave band, OHCs dying by oncosis or apoptosis were uncommon. (c) 2006 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Bohne, BA (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, 660 S Euclid Ave, St Louis, MO 63110 USA.
EM bohneb@ent.wustl.edu
RI Bohne, Barbara/A-9113-2008
OI Bohne, Barbara/0000-0003-3874-7620
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NR 37
TC 31
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 61
EP 70
DI 10.1016/j.heares.2006.10.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500006
PM 17141990
ER
PT J
AU Aizawa, N
Eggermont, JJ
AF Aizawa, Naotaka
Eggermont, Jos J.
TI Mild noise-induced hearing loss at young age affects temporal modulation
transfer functions in adult cat primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE cat; auditory cortex; single unit clusters; noise trauma; temporal
modulation transfer functions
ID RECEPTOR ORGAN DAMAGE; VOICE ONSET TIME; INFERIOR COLLICULUS; COCHLEAR
NUCLEUS; AMPLITUDE-MODULATION; RESPONSES; INHIBITION; TRAUMA;
REPRESENTATIONS; POTENTIALS
AB Kittens were exposed for 2 h to a 1/3rd octave band of noise centered at 5 kHz and at 120 dB SPL. After the exposure, they were kept in a quiet room for at least 4 weeks, and until they were mature. The noise-exposed cats showed on average 16.5 dB higher ABR thresholds and 13.2 dB higher thresholds at the characteristic frequency (CF) than the control cats for frequencies between 4 and 16 kHz. The frequency-tuning curve bandwidth at 20 dB above threshold was significantly increased compared to controls in the CF region of the hearing loss. In noise-exposed cats, temporal modulation-transfer functions (tMTFs) to amplitude-modulated (AM) noise, but not to periodic click trains, showed a marked increase for modulation frequencies (MFs) below 6 Hz. The vectorstrength in noise-exposed cats increased for all modulation frequencies below 32 Hz for neurons with a CF in the range of the hearing loss. The tMTFs for AMnoise in the noise-exposed group were less band-pass compared to the controls, and in that sense the mild hearing loss could be considered as effectively reducing the central activation in the same way as a reduced sound pressure level. Effects of reduced central inhibition are visible in the broadening of frequency-tuning curves, and in the increased limiting rates for AMnoise. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Calgary, Dept Physiol & Biophys, Calgary, AB, Canada.
Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
RP Eggermont, JJ (reprint author), Univ Calgary, Dept Physiol & Biophys, Calgary, AB, Canada.
EM eggermon@ucalgary.ca
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NR 31
TC 7
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 71
EP 82
DI 10.1016/j.heares.2006.09.016
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500007
PM 17123758
ER
PT J
AU Wagner, W
Heppelmann, G
Muller, J
Janssen, T
Zenner, HP
AF Wagner, W.
Heppelmann, G.
Mueller, J.
Janssen, T.
Zenner, H. -P.
TI Olivocochlear reflex effect on human distortion product otoacoustic
emissions is largest at frequencies with distinct fine structure dips
SO HEARING RESEARCH
LA English
DT Article
DE olivocochlear efferents; olivocochlear bundle; olivocochlear reflex;
contralateral suppression; otoacoustic emissions; distortion products
ID CONTRALATERAL SOUND STIMULATION; COCHLEAR MICROMECHANICAL PROPERTIES;
MEDIAL EFFERENT SYSTEM; BROAD-BAND NOISE; ACOUSTIC STIMULATION; RAPID
ADAPTATION; TIME-COURSE; GUINEA-PIG; HUMAN EAR; SUPPRESSION
AB Activity of the medial olivocochlear efferents can be inferred by measuring the change of the level of distortion product otoacoustic emissions (DPOAE) during ipsilateral or contralateral acoustic stimulation, the so-called medial olivocochlear reflex (MOCR). A limitation of this measurement strategy, however, is the distinct variability of MOCR values depending on DPOAE primary tone levels and frequency, which makes selection of the stimulus parameters difficult.
The objective of this study was to evaluate the dependence of MOCR values on DPOAE fine structure in humans. MOCR during contralateral acoustic stimulation was measured at frequencies with distinct non-monotonicity ("dip") in the DPOAE fine structure, and in frequencies with flat fine structure. One hundred and twenty one different primary tone level combinations were used (L-1 = 50-60 dB SPL, L-2 = 35-45 dB SPL, 1 dB steps). The measurement was repeated on another day.
The major findings were: (1) Largest MOCR effects can be found in frequencies which exhibit a distinct dip in DPOAE fine structure. (2) Primary tone levels have a critical influence on the magnitude of the MOCR effect. MOCR changes of up to 23 dB following a L, change of only I dB were observed. Averages of the maximum MOCR change per I dB step were in the 3-5 dB-range. Both findings can be interpreted in the light of the DPOAE two-generator model [Heitmann, J., Waldmann, B., Schnitzler, H.U., Plinkert, P.K., Zenner, H.P. 1998. Suppression of distortion product otoacoustic emissions (DPOAE) near 2f1-f2 removes DP-gram fine structure - evidence for a secondary generator. Journal of the Acoustical Society of America 103, 1527-1531].
According to the present results we propose, that assessing MOCR specifically at frequencies with a distinct dip in the DPOAE fine structure, in combination with fine variation of the stimulus tone levels, allows for a more targeted search for maximum MOCR effects. Future studies must show if this approach can contribute to the further clarification of the physiological roles of the olivocochlear efferents. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Tubingen, Dept Otorhinolaryngol, Tubingen Hearing Res Ctr, D-72076 Tubingen, Germany.
Tech Univ Munich, Dept Otorhinolaryngol, D-8000 Munich, Germany.
RP Wagner, W (reprint author), Univ Tubingen, Dept Otorhinolaryngol, Tubingen Hearing Res Ctr, Elfriede Aulhorn Str 5, D-72076 Tubingen, Germany.
EM w.wagner@med.uni-tuebingen.de
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NR 47
TC 21
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 83
EP 92
DI 10.1016/j.heares.2006.10.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500008
PM 17137736
ER
PT J
AU Dravis, C
Wu, T
Chumley, MJ
Yokoyama, N
Wei, SN
Wu, DK
Marcus, DC
Henkemeyer, M
AF Dravis, Christopher
Wu, Tao
Chumley, Michael J.
Yokoyama, Nobuhiko
Wei, Shiniu
Wu, Doris K.
Marcus, Daniel C.
Henkemeyer, Mark
TI EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular
endolymph
SO HEARING RESEARCH
LA English
DT Article
DE Ephrin-B2; EphB2; receptor tyrosine kinase; vestibular epithelium; dark
cells; transitional cells; endolymph; potassium; ionic homeostasis
ID RECEPTOR TYROSINE KINASE; CRYSTAL-STRUCTURE; STRIA VASCULARIS; DARK
CELLS; INNER-EAR; AUTOPHOSPHORYLATION SITE; TRANSEPITHELIAL VOLTAGE;
TRANSMEMBRANE LIGANDS; TRANSPORT MECHANISMS; COMMISSURAL AXONS
AB The ability to transport cations and anions across epithelia is critical for the regulation of pH, ionic homeostasis, and volume of extracellular fluids. Although the transporters and channels that facilitate ion and water movement across cell membranes are well known, the molecular mechanisms and signal transduction events that regulate these activities remain poorly understood. The Eph family of receptor tyrosine kinases and their membrane-anchored ephrin ligands are well known to transduce bidirectional signals that control axon guidance and other cell migration/adhesion events during development. However, these molecules are also expressed in non-motile epithelial cells, including EphB2 in K+-secreting vestibular dark cells and ephrin-B2 in the adjacent transitional cells of the inner ear. Consistent with these expression patterns, mice with cytoplasmic domain mutations that interfere with EphB2 forward signaling or ephrin-B2 reverse signaling exhibit a hyperactive circling (waltzing) locomotion associated with a decreased amount of endolymph fluid that normally fills the vestibular labyrinth. Endolymph is unusual as an extracellular fluid in that it is normally high in K+ and low in Na+. Direct measurement of this fluid in live animals revealed significant decreases in K+ concentration and endolymphatic potential in both EphB2 and ephrin-B2 mutant mice. Our findings provide evidence that bidirectional signaling mediated by B-subclass Ephs and ephrins controls the production and ionic homeostasis of endolymph fluid and thereby provide the first evidence that these molecules can control the activities of mature epithelial cells. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA.
Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA.
Natl Inst Deafness & Commun Disorders, Mol Biol Lab, Rockville, MD 20850 USA.
RP Henkemeyer, M (reprint author), Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA.
EM mark.henkemeyer@utsouthwestern.edu
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NR 67
TC 23
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 93
EP 104
DI 10.1016/j.heares.2006.10.007
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500009
PM 17158005
ER
PT J
AU Palmer, AR
Liu, LF
Shackleton, TM
AF Palmer, Alan R.
Liu, Liang-fa
Shackleton, Trevor M.
TI Changes in interaural time sensitivity with interaural level differences
in the inferior colliculus
SO HEARING RESEARCH
LA English
DT Article
DE interaural time differences; interaural level differences; inferior
colliculus
ID SUPERIOR OLIVARY COMPLEX; FREQUENCY SOUND LOCALIZATION; AUDITORY-NERVE
FIBERS; CENTRAL NUCLEUS; TEMPORAL DISPARITIES; BINAURAL INTERACTION;
MAMMALIAN COCHLEA; PHASE-LOCKING; SINGLE TONES; GUINEA-PIG
AB We measured interaural time difference (ITD) sensitivity of 72 cells in the inferior colliculus of the anaesthetised guinea pig as a function of frequency and interaural level difference (ILD). For many units there was a "null" frequency, where varying the ILD made no difference to the position of the peak of the ITD sensitivity. This null frequency was not necessarily at the characteristic frequency (CF): it occurred at CF in less than a third of the neurons for which we had sufficient data (14/50). Equally often, the null occurred below (15/50) and less often, above CF (8/50). The remaining (13/50) neurons showed clear phase changes, but these were erratic or parallel and no null could be attributed. In 33 of the 37 neurons with an identifiable null frequency, the peak ITD moved towards the recording side with increasing ILD, for frequencies above the null, and away for frequencies below the null. The changes in ITD sensitivity expressed as phase were maximally about 0.2-0.3 cycles. Many of the changes in response phase with ILD are in the same direction and magnitude as changes in the phase locking with sound level in auditory nerve fibres. Thus, these changes in phase sensitivity at the basilar membrane and auditory nerve are maintained through to ITD tuning in the IC. This is consistent with a coincidence detection mechanism. However, some of the more complex phenomena which we observe are consistent with convergence at the IC. (c) 2006 Elsevier B.V. All rights reserved.
C1 MRC, Inst Hearing Res, Nottingham NG7 2RD, England.
Chinese Peoples Liberat Army Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100853, Peoples R China.
RP Palmer, AR (reprint author), MRC, Inst Hearing Res, Univ Pk, Nottingham NG7 2RD, England.
EM alan.palmer@ihr.mrc.ac.uk; liangfa-liu@hotmail.com;
trevor.shackleton@ihr.mrc.ac.uk
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NR 46
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 105
EP 113
DI 10.1016/j.heares.2006.10.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500010
PM 17141992
ER
PT J
AU Pichora-Fuller, MK
Schneider, BA
MacDonald, E
Pass, HE
Brown, S
AF Pichora-Fuller, M. Kathleen
Schneider, Bruce A.
MacDonald, Ewen
Pass, Hollis E.
Brown, Sasha
TI Temporal jitter disrupts speech intelligibility: A simulation of
auditory aging
SO HEARING RESEARCH
LA English
DT Article
DE aging; temporal jitter; neural synchrony; speech intelligibility; word
identification
ID AGE-RELATED-CHANGES; MASKING-LEVEL DIFFERENCES; NORMAL-HEARING;
FREQUENCY-SELECTIVITY; OLD ADULTS; NOISE; YOUNG; DISCRIMINATION;
ENVELOPE; INTENSITY
AB We disrupted periodicity cues by temporally jittering the speech signal to explore how such distortion might affect word identification. Jittering distorts the fine structure of the speech signal with negligible alteration of either its long-term spectral or amplitude envelope characteristics. In Experiment 1, word identification in noise was significantly reduced in young, normal-hearing adults when sentences were temporally jittered at frequencies below 1.2 kHz. The accuracy of the younger adults in identifying jittered speech in noise was similar to that found previously for older adults with good audiograms when they listened to intact speech in noise. In Experiment 2, to rule out the possibility that the reductions in word identification were due to spectral distortion, we also tested a simulation of cochlear hearing loss that produced spectral distortion equivalent to that produced by jittering, but this simulation had significantly less temporal distortion than was produced by jittering. There was no significant reduction in the accuracy of word identification when only the frequency region below 1.2 kHz was spectrally distorted. Hence, it is the temporal distortion rather than the spectral distortion of the low-frequency components that disrupts word identification. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Toronto, Dept Psychol, Mississauga, ON L5L 1C6, Canada.
Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada.
Univ British Columbia, Sch Audiol & Speech Sci, Vancouver, BC V6T 1Z3, Canada.
RP Pichora-Fuller, MK (reprint author), Univ Toronto, Dept Psychol, 3359 Mississauga Rd, Mississauga, ON L5L 1C6, Canada.
EM kpfuller@utm.utoronto.ca
RI MacDonald, Ewen/B-8841-2013
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NR 44
TC 57
Z9 58
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 114
EP 121
DI 10.1016/j.heares.2006.10.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500011
PM 17157462
ER
PT J
AU Gleich, O
Hamann, I
Kittel, MC
Klump, GM
Strutz, J
AF Gleich, Otto
Hamann, Ingo
Kittel, Malte C.
Klump, Georg M.
Strutz, Juergen
TI Forward masking in gerbils: The effect of age
SO HEARING RESEARCH
LA English
DT Article
DE presbyacusis; aging; peripheral hearing loss; central hearing loss;
psychoacoustic testing; temporal processing
ID NORMAL-HEARING; GAP DETECTION; OLDER-ADULTS; PSYCHOMETRIC FUNCTIONS;
MERIONES-UNGUICULATUS; INFERIOR COLLICULUS; SPEECH RECOGNITION; TEMPORAL
ACUITY; AUDITORY-NERVE; CBA MOUSE
AB We investigated forward masking in 21 gerbils as a function of age (5-47 months) using 400 ms maskers at 40 dB SPL and a 20 ms, 2.85 kHz probe presented 2.5 ins after the masker. Elevated thresholds for the unmasked probe were only observed in animals older than 3 years. Unmasked thresholds showed no significant age-dependent hearing loss in animals below 3 years of age. In these animals without peripheral hearing loss, we found a significant age-dependent increase of masker-induced threshold shift. A regression analysis revealed that threshold shift increased from 23 dB in I year old gerbils to 37 dB in 3 year old animals. Increased forward masking in these animals with no sign of peripheral hearing loss points to a central processing deficit. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Regensburg, ENT Dept, D-93042 Regensburg, Germany.
Univ Oldenburg, AG Zoophysiol & Verhalten, FB 7, D-26111 Oldenburg, Germany.
RP Gleich, O (reprint author), Univ Regensburg, ENT Dept, Franz Josef Str Allee 11, D-93042 Regensburg, Germany.
EM otto.gleich@klinik.uni-regensburg.de; ingo-kva@online.no;
Malte.Kittel@astrazeneca.com; Georg.Klump@uni-oldenburg.de;
juergen.strutz@klinik.uni-regensburg.de
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NR 31
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 122
EP 128
DI 10.1016/j.heares.2006.11.001
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500012
PM 17158007
ER
PT J
AU Frederiksen, BL
Caye-Thomasen, P
Lund, SP
Wagner, N
Asal, K
Olsen, NV
Thomsen, J
AF Frederiksen, Birgitte Lidegaard
Caye-Thomasen, Per
Lund, Soren Peter
Wagner, Niels
Asal, Korhan
Olsen, Niels Vidiendal
Thomsen, Jens
TI Does erythropoietin augment noise induced hearing loss?
SO HEARING RESEARCH
LA English
DT Article
DE EPO; NIHL; inner ear; auditory function; guinea pigs; rats; blood flow
ID CENTRAL-NERVOUS-SYSTEM; BLOOD-FLOW; INNER-EAR; PLEIOTROPIC FUNCTIONS;
CA2+ MOBILIZATION; IN-VITRO; RECEPTOR; NEUROPROTECTION; EXPRESSION;
ISCHEMIA
AB Noise-induced hearing loss may result from excessive release of glutamate, nitrogen oxide and reactive oxygen species. The effects of these factors on the inner ear may potentially be prevented or reduced by erythropoietin (EPO), as indicated by previously demonstrated neuro-protective effects of EPO upon damage to the central nervous system and the retina. This paper reports three separate trials, conducted to investigate the hypothesis that noise-induced hearing loss is prevented or reduced by erythropoietin. The trials employed three different modes of drug application, different administration time windows and different rodent species.
In trial 1, guinea pigs were exposed to 110 dB SPL, 4-20 kHz wide band noise (WBN) for 8 h. EPO was administered to the round window membrane 24 h after noise exposure, either sustained by pump for a week or by single dose middle ear instillation. In trial 2, rats were exposed to 105 dB SPL, 4-20 kHz WBN for 8 h. EPO was administered by single dose middle ear instillation I or 14 h after noise exposure. In trial 3, rats were exposed to 105 dB SPL, 4-20 kHz WBN for 8 or 3 x 8 h. EPO was injected intraperitoneally I h before noise exposure. Oto-acoustic emissions and auditory brainstem responses (at 16 kHz) were recorded before and after noise exposure in all trials. The noise exposure induced a hearing loss in all animals. In trial 1, no recovery and no improvement of hearing occurred in any treatment group. In trial 2 and 3, a partial hearing recovery was seen. However, the hearing loss of the EPO treated animals was significantly worse than controls in trial 2. In trial 3, the hearing of the EPO treated animals exposed for 3 x 8 h was significantly worse than controls. Thus, surprisingly, the results from 2 of the 3 present trials indicate that erythropoietin may in fact augment noise-induced hearing loss. This is contradictory to the beneficial effect of EPO reported by the vast majority of studies on stressed neural tissues. EPO administration may alter the blood flow dynamics of the cochlear vascular bed during or after noise exposure, by a potential induction of vasoconstriction. This may be the cause of the surprising findings. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Copenhagen, Gentofte Hosp, Dept Otorhinolaryngol Head & Neck Surg, DK-2900 Hellerup, Denmark.
Natl Inst Occupat Hlth, AMI, Copenhagen, Denmark.
Univ Copenhagen Hosp, Dept Neuroanaesthesia, DK-2100 Copenhagen, Denmark.
RP Caye-Thomasen, P (reprint author), Univ Copenhagen, Gentofte Hosp, Dept Otorhinolaryngol Head & Neck Surg, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark.
EM peca@gentoftehosp.kbhamt.dk
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NR 36
TC 6
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2007
VL 223
IS 1-2
BP 129
EP 137
DI 10.1016/j.heares.2006.11.002
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 132LO
UT WOS:000243944500013
PM 17158006
ER
PT J
AU Kluk, K
Moore, BCJ
AF Kluk, Karolina
Moore, Brian C. J.
TI Dead regions in the cochlea and enhancement of frequency discrimination:
Effects of audiogram slope, unilateral versus bilateral loss, and
hearing-aid use
SO HEARING RESEARCH
LA English
DT Article
DE dead regions; cortical plasticity; frequency discrimination;
reorganisation
ID PSYCHOPHYSICAL TUNING CURVES; LOUDNESS PERCEPTION; CORTICAL
REORGANIZATION; IMPAIRED TEENAGERS; LOCAL IMPROVEMENT; DIFFERENCE
LIMENS; PITCH PERCEPTION; AUDITORY-SYSTEM; ORGAN DAMAGE; LOSS CUTOFF
AB Following a restricted lesion of the cochlea, which produces a "dead region" (DR), animal experiments have revealed an increase in the cortical representation of frequencies just below the edge frequency (f(e)) of the DR. This may result ill improved difference limens for frequency (DLFs) just below f(e), In previous studies to assess this, the value off, was not determined precisely. We measured DLFs using human subjects with DRs for whom the values of f(e) had been determined precisely using psychophysical tuning curves. To prevent use of loudness cues, stimuli for the measurement of DLFs had a mean level falling along an equal-loudness contour and levels were roved over a 12-dB range. DLFs were measured for thirteen subjects with a DR in at least one ear. Almost all subjects with bilateral hearing loss exhibited enhanced DLFs near f(e), consistent with cortical reorganisation. This Occurred for subjects whose audiograms had both steep and shallow slopes, regardless of hearing aid use, and for two subjects with low-frequency DRs. One subject with a high-frequency DR in one ear and good hearing in the other ear showed all enhanced DLF in her better ear. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
RP Kluk, K (reprint author), Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England.
EM kk278@cam.ac.uk
RI Moore, Brian/I-5541-2012
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NR 57
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 1
EP 15
DI 10.1016/j.heares.2006.06.020
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300001
PM 17071031
ER
PT J
AU Moore, BCJ
Glasberg, BR
Hopkins, K
AF Moore, Brian C. J.
Glasberg, Brian R.
Hopkins, Kathryn
TI Frequency discrimination of complex tones by hearing-impaired subjects:
Evidence for loss of ability to use temporal fine structure
SO HEARING RESEARCH
LA English
DT Article
DE pitch; temporal fine structure; hearing impairment; frequency
discrimination; phase sensitivity
ID MODULATION RATE DISCRIMINATION; AUDITORY FILTER SHAPES;
AMPLITUDE-MODULATION; UNRESOLVED HARMONICS; PITCH PERCEPTION;
PHASE-LOCKING; NERVE FIBERS; HAIR-CELLS; GUINEA-PIG; LISTENERS
AB For normally hearing subjects, thresholds for discriminating the fundamental frequency (F0) of a complex tone, F0DLs, increase when the number of the lowest harmonic, N, is above eight. A previous study showed that F0DLs were affected by component phase for N above 7, and it was argued that the increase in F0DLs with increasing N reflects a loss of temporal fine structure information. Here, subjects with moderate hearing loss were tested in a similar experiment. F0DLs were measured for tones with three successive harmonics, added in cosine or alternating phase. The center frequency was 2000 Hz. N was varied by changing the mean F0. A background noise was used to mask combination tones. F was roved across trials and N was roved by +/- 1, to reduce use of excitation pattern cues. F0DLs were smaller for cosine than for alternating phase for four out of six subjects, and this occurred once N exceeded 5. 111 contrast to the result for normally hearing subjects, F0DLs decreased with increasing N. Performance was much worse than obtained for normally hearing subjects at the same center frequency, suggesting that most of the hearing-impaired subjects had a poor ability to use temporal fine structure information. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
RP Moore, BCJ (reprint author), Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England.
EM bcjm@cam.ac.uk
RI Hopkins, Kathryn/E-2203-2012; Moore, Brian/I-5541-2012
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NR 67
TC 30
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 16
EP 27
DI 10.1016/j.heares.2006.08.007
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300002
PM 17030477
ER
PT J
AU Vautrin, J
Travo, C
Boyer, C
Venteo, S
Favre, D
Dechesne, CJ
AF Vautrin, Jean
Travo, Cecile
Boyer, Catherine
Venteo, Stephanie
Favre, Daniel
Dechesne, Claude J.
TI Ocsyn and mitochondrial-canalicular complexes in vestibular hair cells
SO HEARING RESEARCH
LA English
DT Article
DE inner ear; sensory cells; mitochondria; canalicular reticulum; rat;
guinea pig; confocal microscopy
ID SYNAPTOPHYSIN EXPRESSION; CA2+ HOMEOSTASIS; CUTICULAR PLATE; END-ORGANS;
PROTEIN; IMMUNOREACTIVITY; MICROTUBULES; ORGANIZATION; TRANSPORT;
GANGLION
AB Ocsyn. a syntaxin-interacting protein characterized by Safieddine et al. [Safieddine, S., Ly, C.D., Wang Y.-X., Kachar, B., Petralia, R.S., Wenthold, R.J., 2002. Ocsyn, a novel syntaxin-interacting protein enriched in the subapical region of inner hair cells. Mol. Cell. Neurosci., 20, 343-353] in the guinea pig organ of Corti was primarily identified in organelles located at the subapical region of inner hair cells. They proposed that in cochlear inner hair cells, ocsyn was involved in protein trafficking associated to recycling endosomes. Ocsyn happens to be highly homologous to syntabulin with an almost identical syntaxin-binding domain. Syntabulin is believed to attach syntaxin-containing vesicles to kinesin for their axonal transport along microtubules. The present study shows the distribution of ocsyn in guinea pig and rat vestibular hair cells using immunocytochemistry and confocal microscopy. Ocsyn was characterized by intense immunolabeled spots distributed exclusively in type I and 11 vestibular hair cells. The subcuticular region under the cuticular plate exhibited particularly densely packed spots. In the neck region of the sensory cells, where microtubules are abundant, there was no colocalization of ocsyn and alpha-tubulin. Ocsyn labeled spots were also present in the medial and basal hair cell regions, particularly in the supranuclear and infranuclear regions. Mitochondria are particularly numerous in these three regions (subcuticular, supranuclear and infranuclear). Double labeling of ocsyri and cytochrome c showed that ocsyn was present in the same zones that mitochondria. This, together with the great similarity of ocsyn and syntabulin, suggest that, akin to syntabulin, ocsyn is involved in addressing organelles. We propose that ocsyn is involved in the formation of the canalicular-mitochondrial complexes depicted by Spicer et al. [Spicer, S.S., Thomopoulos, G.N., Schulte, B.A., 1999. Novel membranous structures in apical and basal compartments of inner hear cells. J. Comp. Neurol., 409, 424-437]. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Montpellier 2, LIRDEF, F-34095 Montpellier 5, France.
Univ Montpellier 2, INSERM, U343, F-34095 Montpellier, France.
INSERM, U583, INM, F-34091 Montpellier 5, France.
RP Dechesne, CJ (reprint author), Univ Montpellier 2, LIRDEF, CC 077,Pl Bataillon, F-34095 Montpellier 5, France.
EM Jean.Vautrin@univ-montp2.fr; cecile.travo@montp.inserm.fr;
c.boyer@univ-montp2.fr; venteo@univ-montp2.fr; favre@univ-montp2.fr;
claudejd@univ-montp2.fr
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NR 26
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 28
EP 34
DI 10.1016/j.heares.2006.07.017
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300003
PM 17045436
ER
PT J
AU Hoffman, LF
Ross, MD
Varelas, J
Jones, SM
Jones, TA
AF Hoffman, Larry F.
Ross, Muriel D.
Varelas, Joseph
Jones, Sherri M.
Jones, Timothy A.
TI Afferent synapses are present in utricular hair cells from
otoconia-deficient mice
SO HEARING RESEARCH
LA English
DT Article
DE head-tilt; synaptic ribbon; labyrinth; gravity orientation; vestibular
ID MORPHOLOGICAL-CHANGES; RIBBON SYNAPSES; FINE-STRUCTURE; MUTANT MICE;
GUINEA-PIG; MOUSE; ORGAN; CORTI; CAT; WEIGHTLESSNESS
AB The head tilt mouse (het/het, abbr. het) is a naturally occurring mutant whose salient phenotypic traits include the complete absence of otocoina in both the utricle and saccule. Cursory histologic evaluation has indicated that the neuroepithelia exhibit a normal appearance. Though evidence exists indicating that utricular function is severely if not completely compromised in these animals, it is not yet known whether afferent synapses exist within utricular hair cells of otoconia-deficient mutants. The absence of synapses would be suggestive of a trophic relationship between stimulus-evoked hair cell activation and the afferent synapse. To address this question, we have conducted an ultrastructural survey of utricular sensory epithelia from confirmed het mice. The specific objective was to determine whether utricular hair Cells Made Synaptic contact with afferent neurons. We found that both type I and 11 hair cells from utricles of het mice exhibited afferent synapses that were found at numerous sites distributed throughout the Utricle. These results indicate that afferent synapses within vestibular hair cells do not critically depend upon stimulus-evoked activity. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, Los Angeles, CA 90095 USA.
Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Los Angeles, CA 90095 USA.
Univ New Mexico, Hlth Sci Ctr, Dept Neurosci, Albuquerque, NM 87131 USA.
NASA, Ames Res Ctr, BioVIS Technol Ctr, Moffett Field, CA 94035 USA.
E Carolina Univ, Dept Commun Sci & Disorders, Sch Allied Hlth Sci, Greenville, NC 27858 USA.
RP Hoffman, LF (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, Box 951624, Los Angeles, CA 90095 USA.
EM lfh@ucla.edu
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NR 35
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 35
EP 42
DI 10.1016/j.heares.2006.05.013
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300004
PM 17023128
ER
PT J
AU Vetesnik, A
Nobili, R
AF Vetesnik, A.
Nobili, R.
TI The approximate scaling law of the cochlea box model
SO HEARING RESEARCH
LA English
DT Article
DE cochlea amplifier; scaling law; local covariance; distributed parameter
control
ID BASILAR-MEMBRANE STIFFNESS; PHYSICAL PRINCIPLES; MOSSBAUER TECHNIQUE;
AUDITORY PHYSICS; HEARING THEORY; MOTION
AB The hydrodynamic box-model of the cochlea is reconsidered here for the primary-V Purpose of studying in detail the approximate scaling law that governs tonotopic responses in the frequency domain. "Scaling law" here means that any two Solutions representing waveforms elicited by tones of equal amplitudes differ only by a complex factor depending on frequency. It is shown that this property holds with excellent approximation almost all along the basilar membrane (BM) length. with the exception of small region adjacent to the BM base. The analytical expression of the approximate law is explicitly given and compared to numerical solutions carried Out On a virtually exact implementation of the model. It differs significantly from that derived by Sondhi in 1978, which suffers from an inaccuracy in the hyperbolic approximation of the exact Green's function. Since the cochleae of mammals do not exhibit the scaling properties of the box model, the subject presented here may appear to be just an academic exercise. The results Of our study, however. are significant in that a more general scaling law should hold for real cochleae. To support this hypothesis, an argument related to the problem of cochlear amplifier-gain stabilization is advanced. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Padua, Dept Phys G Galilei, I-35131 Padua, Italy.
Univ Tubingen, Dept Otolaryngol, D-72076 Tubingen, Germany.
RP Nobili, R (reprint author), Univ Padua, Dept Phys G Galilei, Via Marzolo 8, I-35131 Padua, Italy.
EM renato.nobili@pd.infn.it
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NR 24
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 43
EP 53
DI 10.1016/j.heares.2006.08.012
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300005
PM 17008036
ER
PT J
AU Chen, GD
AF Chen, Guang-Di
TI Prestin gene expression in the rat cochlea following intense noise
exposure
SO HEARING RESEARCH
LA English
DT Article
DE prestin; OHC motor protein; cochlear amplification; noise-induced
hearing loss; OHC cytoskeleton
ID OUTER HAIR-CELLS; ELECTROKINETIC SHAPE CHANGES; INDUCED HEARING-LOSS;
ACTIN-FILAMENTS; MOTOR PROTEIN; INNER-EAR; F-ACTIN; ELECTROMOTILITY;
LOCALIZATION; CYTOSKELETAL
AB Noise-induced permanent loss of cochlear amplification was observed previously with the majority of outer hair cells (OHCs) still surviving in the cochlea and even with a normal OHC receptor potential, indicated by CM (cochlear microphonics) recording [Chen, G.D., Fechter, L.D., 2003. The relationship between noise-induced hearing loss and hair cell loss in rats. Hear. Res. 177(1-2), 81-90 Chen, G.D., Liu, Y., 2005. Mechanisms of noise-induced hearing loss potentiation by hypoxia. Hear. Res. 200, 1-9]. This study focused on effects of an intense noise exposure (10-20 kHz at a level of 110 dB SPL for 4 It) on the OHC motor protein (prestin) and structural proteins in the OHC membrane skeleton. The noise exposure significantly disrupted CM and CAP (cochlear compound action potential). The injured CM recovered after]-week resting period. The impaired CAP at frequencies lower than the noise band also recovered. However, the CAP recovery at frequencies of the noise band stopped at a linear line one week after the noise exposure, indicating a permanent loss of cochlear amplification. Gene expression of prestin, beta-spectrin, and beta-actin was significantly up-regulated after the noise exposure. The elevated gene expression peaked at the 3rd post-exposure day and returned to baseline 4 weeks after the noise exposure. The up-regulated gene expression may be in response to injury of the proteins, which may be responsible for the loss of cochlear amplification. (c) 2006 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Chen, GD (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM gchen7@buffalo.edu
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NR 42
TC 20
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 54
EP 61
DI 10.1016/j.heares.2006.08.011
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300006
PM 17005342
ER
PT J
AU Kevanishvili, Z
Hofmann, G
Burdzgla, I
Pietsch, M
Gamgebeli, Z
Yarin, Y
Tushishvili, M
Zahnert, T
AF Kevanishvili, Zurab
Hofmann, Gert
Burdzgla, Irina
Pietsch, Markus
Gamgebeli, Zurab
Yarin, Yury
Tushishvili, Michael
Zahnert, Thomas
TI Behavior of evoked otoacoustic emission under low-frequency tone
exposure: Objective study of the bounce phenomenon in humans
SO HEARING RESEARCH
LA English
DT Article
DE bounce phenomenon; EOAE effects; acquisition dependence; exposure
intensity dependence; ipsilateral vs. contralateral effects
ID COMPOUND ACTION-POTENTIALS; POSTEXPOSURE RESPONSIVENESS; AUDITORY
SYSTEM; SENSITIZATION; MODULATION; COCHLEA; SOUND; SENSITIVITY
AB The bounce phenomenon has been investigated in humans, evaluating alterations of click evoked otoacoustic emission (EOAE) after presentation of 250-Hz frequency loud tones during 3 min. EOAE changes were manifested in initial augmentation followed by reduction, peaking at 1 and 3 min of post-exposure time, respectively. Recoveries took 5-7 min afterwards. Under linear and nonlinear EOAE acquisition modes both manifestations of bounce appeared similar. At lower exposure intensities, 65-75 dB SPL, augmentations prevailed over reductions. At higher intensities, 80-95 dB SPL, augmentations and reductions were of similar magnitudes. At highest intensity, 100 dB SPL, an obvious EOAE drop has hardly been preceded by any augmentation. Based upon these data, the bounce is considered to be a compound of two opposite events, appearance of each being dependent upon the exposure level. Subjects with high bounce indices in one ear displayed comparable indices in other ear too. Low bounce magnitudes were accordingly typical for particular subjects irrespective of the ears tested. EOAE alterations were observed under ipsilateral, but not contralateral exposures of tones. It has been concluded therefore that the bounce involves peripheral receptor rather than central neural mechanisms. No EOAE shifts were seen under application of clicks without any low-frequency exposure tones. Correspondingly, the bounce is judged to reflect inner-ear processes triggered by low-frequency tones, but not by regular presentations of test-stimuli. (c) 2006 Elsevier B.V. All rights reserved.
C1 Ctr Audiol & Hearing Rehabil, GE-0179 Tbilisi, Rep of Georgia.
Tech Univ Dresden, Otorhinolaryngol Clin, D-01307 Dresden, Germany.
Univ Munich, D-80539 Munich, Germany.
RP Kevanishvili, Z (reprint author), Ctr Audiol & Hearing Rehabil, Chavchavadze Ave 33, GE-0179 Tbilisi, Rep of Georgia.
EM zuriko_k@hotmail.com
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NR 22
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 62
EP 69
DI 10.1016/j.heares.2006.05.014
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300007
PM 17052872
ER
PT J
AU Gu, FM
Han, HL
Zhang, LS
AF Gu, Feng-ming
Han, Hong-lei
Zhang, Lian-shan
TI Effects of vasopressin on gene expression in rat inner ear
SO HEARING RESEARCH
LA English
DT Article
DE vasopressin; inner ear; gene expression; microarray; aquaporin;
endolymphatic hydrops
ID ANTI-DIURETIC HORMONE; ADENYLATE-CYCLASE; CYTOCHEMICAL-LOCALIZATION;
ENDOLYMPHATIC SAC; MENIERES-DISEASE; STRIA VASCULARIS; MARGINAL CELLS;
ARGININE-VASOPRESSIN; MESSENGER-RNAS; GUINEA-PIG
AB Vasopressin regulates water excretion from the kidney by increasing water permeability of the collecting duct as a hormone secreted from the posterior pituitary. A clinical study reported that plasma levels of arginine vasopressin were significantly higher in patients suffering from Meniere's disease. It was histologically confirmed that chronic administration of vasopressin induced endolymphatic hydrops in guinea pigs. However, the mechanism of endolymphatic hydrops induced by vasopressin is still unclear. We use cDNA microarray to study the effects of vasopressin on gene expression profiles in rat inner ear to elucidate the possible mechanism of the induced hydrolabyrinth. Wistar rats were intraperitoneally injected with 50 kg/kg arginine vasopressin once a day for one week. Hydrolabyrinth in rat inner ear induced by administration of vasopressin was detected by HE stain. The bullae were dissected out for total RNA extraction. cDNAs were synthesized by reverse transcription and labeled with Cyanine3 (Cy3) or Cyanine5 (Cy5). The Biostar R-40s cDNA microarray was hybridized with the above cDNAs and the changes of mRNA expression intensity were showed by data analysis. Furthermore, the changes of aquaporins expression level were measured by reverse transcription polymerase chain (RT-PCR). Endolymphatic hydrops were present in rats intraperitoneally injected with vasopressin. 226 known differentially expressed genes were screened out in rat inner ear induced by vasopressin injection. Of the 226 genes, IS transcripts were increased by 5-fold or more, and 7 transcripts were decreased to 0.2-fold or less. Ten differentially expressed genes were identified that associate with cell signal transduction, 14 differentially expressed genes were identified that relate to ion transport, 7 differentially expressed genes were involved in vesicle-mediated transport, and 2 differentially expressed genes were aquaporin 2 (AQP2) and aquaporin 7 (AQP7), The expression level of AQP2 was significantly higher and AQP7 was significantly lower. These results suggest that there are obvious differences in gene expression profiles in inner ear between vasopressin injected rats and normal control rats. Vasopressin may disturb fluid homeostasis in inner ear by way of signal transduction, ion transport, vesicle-mediated transport and aquaporins. It is likely that up-regulated expression of AQP2 mRNA and down-regulated expression of AQP7 mRNA in the rat inner ear caused by vasopressin induce an increased production and a decreased absorption of endolymph, resulting in endolymphatic hydrops. (c) 2006 Published by Elsevier B.V.
C1 Fudan Univ, Dept Otolaryngol Eye Ear Nose & Throat Hosp, Shanghai 200031, Peoples R China.
China Japan Friendship Hosp, Dept Otolaryngol, Beijing 100029, Peoples R China.
Union Med Univ, Beijing 100730, Peoples R China.
Peking Union Med Hosp, Chinese Acad Sci, Dept Otolaryngol, Beijing 100730, Peoples R China.
RP Gu, FM (reprint author), Fudan Univ, Dept Otolaryngol Eye Ear Nose & Throat Hosp, 83 Fenyang Rd, Shanghai 200031, Peoples R China.
EM fengming.gu@gmail.com; hanhonglei@hotmail.com; zhangls@sohu.com
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NR 38
TC 11
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 70
EP 78
DI 10.1016/j.heares.2006.08.016
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300008
PM 17070001
ER
PT J
AU Roberts, B
Holmes, SD
AF Roberts, Brian
Holmes, Stephen D.
TI Grouping and the pitch of a mistuned fundamental component: Effects of
applying simultaneous multiple mistunings to the other harmonics
SO HEARING RESEARCH
LA English
DT Article
DE auditory grouping; harmonic relations; mistuning; pitch shifts
ID COMPLEX TONES; PERCEPTUAL SEGREGATION; SPECTRAL PATTERN; PARTIALS;
FREQUENCY; FUSION; SHIFTS; MODEL; TEMPLATE; HEARING
AB Mistuning a harmonic produces In exaggerated change in its pitch. This occurs because the component becomes inconsistent with the regular pattern that Causes the other harmonics (Constituting the spectral frame) to integrate perceptually. These pitch shifts were measured when the fundamental (F0) component of a complex tone (norminal FO frequency = 200 Hz) was mistuned by +8% and -8%,). The pitch-shift gradient was defined as the difference between these values and its magnitude was used its a measure of frame integration. An independent Ad random perturbation (spectral jitter) wits applied simulateously to most or all of the frame components. The gradient magnitude declined gradually as the degree of jitter increased from 0% to +/- 40% of F0. The component adjacent to the mistuned target made the largest contribution to the gradient. but more distant components also contributed. The Stimuli were passed through an auditory model, and the exponential height of the F0-period peak in the averaged summary autocorrelation function correlated well with the gradient magnitude. The fit improved when the weighting on more distant channels was attenuated by a factor of three per octave. The results are consistent with a grouping mechanism that computes a weighted average of periodicity strength across several components. (c) 2006 Elsevier B.V. All rights reserved.
C1 Aston Univ, Sch Life & Hth Sci, Birmingham B4 7ET, W Midlands, England.
Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England.
RP Roberts, B (reprint author), Aston Univ, Sch Life & Hth Sci, Birmingham B4 7ET, W Midlands, England.
EM b.roberts@aston.ac.uk
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NR 39
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 79
EP 88
DI 10.1016/j.heares.2006.08.013
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300009
PM 17055676
ER
PT J
AU Chen, WC
Davis, RL
AF Chen, Wei Chun
Davis, Robin L.
TI Voltage-gated and two-pore-domain potassium channels in murine spiral
ganglion neurons
SO HEARING RESEARCH
LA English
DT Article
DE Kv3.3; TWIK-1; KCNK; tandem pore; spiral ganglion; auditory; cochlea
ID DOMAIN K+ CHANNELS; RAT-BRAIN; DIFFERENTIAL EXPRESSION; AUDITORY
NEURONS; NERVE-TERMINALS; FIRING PATTERNS; ALPHA-SUBUNITS; MOUSE;
CURRENTS; TREK-1
AB The systematically varied firing features Of spiral ganglion neurous provide an excellent model system for the exploration of how graded ion channel distributions can be used to organize neuronal firing across a population of neurons. Elucidating the underlying mechanisms that determine neuronal response properties requires a complete Understanding of the combination of ion channels. auxiliary proteins, modulators, and second messengers that form this highly organized system in the auditory periphery. Toward this goal, we built upon previous studies of voltage-gated K+-selective ion channels (Kv), and expanded Our analysis to K+-selective leak channels (KCNK), which can play a major role in setting the basic firing characteristics of spirit] ganglion neurons.
To begin a more comprehensive analysis of Kv and KCNK channels, a screening approach was employed. RT-PCR was utilized to examine gene expression, the major results of which were confirmed with immunochemistry. initial Studies validated this approach by accurately detecting voltage-dependent K+ channels that were documented previously in the spiral ganglion. Furthermore, an additional channel type within the Kv3 family, Kv3.3, was identified and further characterized. The major focus Of the Study. however, was to systematically examine gene expression levels of the KCNK family of K+-selective leak channels. These channel types determine the resting membrane potential which has a major impact oil setting the level Of neuronal excitation. TWIK-1. TASK-3. TASK-1, and TREK-1 were expressed in the spiral ganglion TWIK-1 was specifically localized with immunocytochemistry to the neuronal sonata and initial processes of spiral ganglion neurons in vitro. (c) 2006 Elsevier B.V. All rights reserved.
C1 Rutgers State Univ, Nelson Labs, Dept Cell Biol & Neurosci, Piscataway, NJ 08854 USA.
RP Davis, RL (reprint author), Rutgers State Univ, Nelson Labs, Dept Cell Biol & Neurosci, 604 Allison Rd, Piscataway, NJ 08854 USA.
EM rldavis@rci.rutgers.edu
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NR 58
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 89
EP 99
DI 10.1016/j.heares.2006.09.002
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300010
PM 17079103
ER
PT J
AU Chatterjee, M
Sarampalis, A
Oba, SI
AF Chatterjee, Monita
Sarampalis, Anastasios
Oba, Sandra I.
TI Auditory stream segregation with cochlear implants: A preliminary report
SO HEARING RESEARCH
LA English
DT Article
DE auditory streaming; cochlear implants; modulation
ID FUNDAMENTAL-FREQUENCY; IMPAIRED LISTENERS; SEQUENCES; ATTENTION
AB Auditory stream segregation was measured in cochlear implant (0) listeners using a subjective "Yes-No" task in which listeners indicated whether a sequence of stimuli was perceived as two separate streams or not. Stimuli were brief, 50-ms pulse trains A and B, presented in an A_B_A_A_B_A...sequence, with 50 ms in between consecutive stimuli. All stimuli were carefully loudness-balanced prior to the experiments. The cochlear electrode location of A was fixed, while the location of B was varied systematically. Measures of electrode discrimination and subjective perceptual difference were also included for comparison. There was strong intersubject variation in the pattern of results. One of the participants participated in a second series of experiments, the results of which indicated that he was able to perceptually segregate stimuli that were different in cochlear electrode location, as well as stimuli that were different in temporal envelope. Although preliminary, these results suggest that it is possible for some cochlear implant listeners to perceptually segregate stimuli based on differences in cochlear location as well as temporal envelope. (c) 2006 Elsevier B.V. All rights reserved.
C1 House Ear Res Inst, Dept Auditory Implants & Percept, Los Angeles, CA 90057 USA.
RP Chatterjee, M (reprint author), Univ Maryland, Dept Speech & Hearing Sci, 0100 LeFrak Hall, College Pk, MD 20742 USA.
EM mchatterjee@hesp.umd.edu
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NR 27
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 100
EP 107
DI 10.1016/j.heares.2006.09.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300011
PM 17071032
ER
PT J
AU Weisz, N
Hartmann, T
Dohrmann, K
Schlee, W
Norena, A
AF Weisz, Nathan
Hartmann, Thomas
Dohrmann, Katalin
Schlee, Winfried
Norena, Arnaud
TI High-frequency tinnitus without hearing loss does not mean absence of
deafferentation
SO HEARING RESEARCH
LA English
DT Article
DE tinnitus; tinnitus spectrum; hearing loss; dead regions; pitch scaling
ID CORTICAL REORGANIZATION
AB A broad consensus within the neuroscience of tinnitus holds that this audiologic condition is triggered by central deafferentation, mostly due to cochlear damage. The absence of audiometrically detectable hearing loss however poses a challenge to this rather generalizing assumption. The aim of this study was therefore to scrutinize cochlear functioning in a sample of tinnitus subjects audiometrically matched to a normal hearing control group. Two tests were applied: the Threshold Equalizing Noise (TEN) test and a pitch scaling task. To perform well on both tasks relatively normal functioning of inner hair cells is a requirement. In the TEN test the tinnitus group revealed a circumscribed increment of thresholds partially overlapping with the tinnitus spectrum. Abnormal slopes were observed in the pitch scaling task which indicated that tinnitus subjects, when presented with a high-frequency stimulus, relied heavily on input derived from lower-frequency inner hair cells (off-frequency listening). In total both results argue for the presence of a deafferentation also in tinnitus subjects with audiometrically normal thresholds and therefore favour the deafferentation assumption posed by most neuroscientific theories. (c) 2006 Elsevier B.V. All rights reserved.
C1 INSERM, U280, F-69500 Bron, France.
Univ Konstanz, Dept Psychol, D-7750 Constance, Germany.
Univ Lyon 1, CNRS, UMR 5020, F-69622 Villeurbanne, France.
RP Weisz, N (reprint author), INSERM, U280, 95 Blvd Pinel, F-69500 Bron, France.
EM weisz@lyon.inserm.fr
RI Schlee, Winfried/C-8983-2011
OI Schlee, Winfried/0000-0001-7942-1788
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NR 19
TC 98
Z9 104
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 108
EP 114
DI 10.1016/j.heares.2006.09.003
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300012
PM 17079102
ER
PT J
AU Tornabene, SV
Sato, K
Pham, L
Billings, P
Keithley, EM
AF Tornabene, Stephen V.
Sato, Kunihiro
Pham, Liem
Billings, Peter
Keithley, Elizabeth M.
TI Immune cell recruitment following acoustic trauma
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; chemokines; macrophages; wound healing
ID SPIRAL LIGAMENT FIBROCYTES; NECROSIS-FACTOR-ALPHA; INNER-EAR;
PROINFLAMMATORY CYTOKINES; COCHLEAR INFLAMMATION; CONTUSION INJURY;
MOUSE COCHLEA; SPINAL-CORD; EXPRESSION; RAT
AB Acoustic trauma induces Cochlear inflammation. We hypothesized that chemokines are involved in the recruitment of leukocytes as part of a wound healing response. The cochleas of NIH-Swiss mice, exposed to octave-band noise (8-16 kHz, at I IS dB) for 2 hi were examined after the termination of exposure. Leukocytes were identified immunohistochemistry with antibodies to CD45 and F4/80. Gene array analysis followed by RT-PCR was performed Oil cochlear tissue to identify Up-regulation of chemokine and adhesion molecule mRNA. The expression of the adhesion Molecule ICAM-1 was also investigated immunochemistry. Few CD45- or F4/80-positive leukocytes were observed in the non-exposed cochlea. Following acoustic trauma however, the number of CD45-positive cells was dramatically increased especially after 2 and 4 days, after which time the numbers decreased. F4/80-positive cells also increased in number over the course of a week. Gene array analysis indicated increased expression of monocyte chemoattractant protein 5 (MCP-5), monocyte chemoattractant protein I (MCP-1), macrophage inflammatory protein-1 beta (MIP-1 beta) and ICAM-1. RT-PCR, performed using primers for the individual mRNA sequences, confirmed the increased expression of MCP-1, MCP-5. MIP-1, and ICAM-1 relative to non-exposed mice. In the normal cochlea, ICAM-1 immunohistochemical expression was observed in venules, spiral ligament fibrocytes and in endosteal cells of the scala tympani. Expression increased to include more of the spiral ligament and endosteal cells after acoustic trauma. A cochlear inflammatory response is initiated in response to acoustric trauma and involves the recruitment of circulating leukocytes to the inner ear. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Calif San Diego, Div Otolaryngol Head & Neck Surg, La Jolla, CA 92093 USA.
San Diego VA Med Ctr, Dept Vet Affairs, Div Med Res, La Jolla, CA USA.
RP Keithley, EM (reprint author), Univ Calif San Diego, Div Otolaryngol Head & Neck Surg, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM ekeithley@ucsd.edu
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NR 31
TC 34
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 115
EP 124
DI 10.1016/j.heares.2006.09.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300013
PM 17081714
ER
PT J
AU Soeta, Y
Nakagawa, S
AF Soeta, Yoshiharu
Nakagawa, Seiji
TI Complex tone processing and critical band in the human auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE auditory-evoked fields (AEFs); critical band; critical bandwidth;
magnetoencephalography (MEG); N1m
ID EVOKED MAGNETIC-FIELDS; ITERATED RIPPLED NOISE; ELECTROPHYSIOLOGICAL
EVIDENCE; PITCH STRENGTH; LOUDNESS; SOUNDS; REPRESENTATION; BANDWIDTH;
RESPONSES
AB Psychophysical experiments in humans have indicated that the auditory system has a well-defined bandwidth for resolution of complex stimuli. This bandwidth is known as the critical bandwidth (CBW). Physiological correlates of the CBW were examined in the human auditory cortex. Two- and three-tone complexes were used as the sound stimuli with all signals presented at 55 dB sound pressure level (SPL). The duration of stimulation was 500 ins, with rise and fall ramps of 10 ins. Tell normal-hearing subjects took part in the study. Auditory-evoked fields were recorded using a 122-channel whole-head magnetometer in a magnetically shielded room. The latencies, source strengths, and coordinates of the N1m waves, which were found above the left and right temporal lobes approximately 100 ms after the onset of stimulation, were analyzed. The results indicated that NI in amplitudes were approximately constant when the frequency separation of a two-tone complex or the total bandwidth of a three-tone complex was less than the CBW; however, the N1m amplitudes increased with increasing frequency separation or total bandwidth when these were greater than the CBW. These findings indicate critical band-like behavior in the human auditory cortex. The NI in amplitudes in the right hemisphere were significantly greater than those in the left hemisphere, which may reflect a right-hemispheric dominance in the processing of tonal Stimuli. (c) 2006 Elsevier B.V. All rights reserved.
C1 Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
RP Soeta, Y (reprint author), Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, 1-8-31 Midorigaoka, Ikeda, Osaka 5638577, Japan.
EM y.soeta@aist.go.jp
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NR 30
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2006
VL 222
IS 1-2
BP 125
EP 132
DI 10.1016/j.heares.2006.09.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 117YN
UT WOS:000242909300014
PM 17081712
ER
PT J
AU Coffey, CS
Ebert, CS
Marshall, AF
Skaggs, JD
Falk, SE
Crocker, WD
Pearson, JM
Fitzpatrick, DC
AF Coffey, Charles S.
Ebert, Charles S., Jr.
Marshall, Allen F.
Skaggs, John D.
Falk, Stephanie E.
Crocker, William D.
Pearson, James M.
Fitzpatrick, Douglas C.
TI Detection of interaural correlation by neurons in the superior olivary
complex, inferior colliculus and auditory cortex of the unanesthetized
rabbit
SO HEARING RESEARCH
LA English
DT Article
DE sound localization; interaural temporal disparities; interaural time
differences; acoustic space
ID LOW-FREQUENCY NEURONS; TIME DIFFERENCE DISCRIMINATION; CHICK BRAIN-STEM;
SOUND LOCALIZATION; DELAY-LINES; COINCIDENCE DETECTION;
BINAURAL-INTERACTION; CROSS-CORRELATION; NOISE STIMULI; TONOTOPIC
ORGANIZATION
AB A critical binaural cue important for sound localization and detection of signals in noise is the interaural time difference (ITD), or difference in the time of arrival of sounds at each ear. The ITD can be determined by cross-correlating the sounds at the two ears and finding the ITD where the correlation is maximal. The amount of interaural correlation is affected by properties of spaces and can therefore be used to assess spatial attributes. To examine the neural basis for sensitivity to the overall level of the interaural correlation, we identified subcollicular neurons and neurons in the inferior colliculus (IC) and auditory cortex of unanesthetized rabbits that were sensitive to ITDs and examined their responses as the interaural correlation was varied. Neurons at each brain level could show linear or non-linear responses to changes in interaural correlation. The direction of the non-linearities in most neurons was to increase the slope of the response change for correlations near 1.0. The proportion of neurons with non-linear responses was similar in subcollicular and IC neurons but increased in the auditory cortex. Non-linear response functions to interaural correlation were not related to the type of response as determined by the tuning to ITDs across frequencies. The responses to interaural correlation were also not related to the frequency tuning of the neuron, unlike the responses to ITD, which broadens for neurons tuned to lower frequencies. The neural discriminibility of the ITD using frozen noise in the best neurons was similar to the behavioral acuity in humans at a reference correlation of 1.0. However, for other reference ITDs the neural discriminibility was more linear and generally better than the human discriminibility of the interaural correlation, suggesting that stimulus rather than neural variability is the basis for the decline in human performance at lower levels of interaural correlation. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA.
RP Fitzpatrick, DC (reprint author), Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, 101 Med Res Bldg A,CB 7070, Chapel Hill, NC 27599 USA.
EM dcf@med.unc.edu
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NR 67
TC 22
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 1
EP 16
DI 10.1016/j.jheares.2006.06.005
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700001
PM 16978812
ER
PT J
AU Heffner, RS
Koay, G
Heffner, HE
AF Heffner, R. S.
Koay, G.
Heffner, H. E.
TI Hearing in large (Eidolon helvum) and small (Cynopterus brachyotis)
non-echolocating fruit bats
SO HEARING RESEARCH
LA English
DT Article
DE audiogram; megachiroptera; yinpterochiroptera; pteropodiformes;
straw-colored fruit bat; dog-faced fruit bat; echolocation; evolution
ID BIG BROWN BAT; MONKEY SAIMIRI-SCIUREUS; PURE-TONE THRESHOLDS; LEAF-NOSED
BATS; SOUND-LOCALIZATION; PRIMITIVE MAMMALS; AUDITORY-SENSITIVITY;
EPTESICUS-FUSCUS; ROUSETTUS-AEGYPTIACUS; BEHAVIORAL AUDIOGRAMS
AB Comparing the hearing abilities of echolocating and non-echolocating bats can provide insight into the effect of echolocation on more basic hearing abilities. Toward this end, we determined the audiograms of two species of non-echolocating bats, the straw-colored fruit bat (Eidolon helvum), a large (230-350 g) African fruit bat, and the dog-faced fruit bat (Cynopterus brachyotis), a small (3045 g) bat native to India and Southeast Asia. A conditioned suppression/avoidance procedure with a fruit juice reward was used for testing. At 60 dB SPL, the hearing range of E. helvum extends from 1.38 to 41 kHz with best sensitivity at 8 kHz; the hearing range of C brachyotis extends from 2.63 to 70 kHz with best sensitivity at 10 kHz. As with all other bats tested so far, neither species was able to hear below 500 Hz, suggesting that they may not use a time code for perceiving pitch. Comparison of the high-frequency hearing abilities of echolocating and non-echolocating bats suggests that the use of laryngeal echolocation has resulted in additional selective pressure to hear high frequencies. However, the typical high-frequency sensitivity of small non-echolocating mammals would have been sufficient to support initial echolocation in the early evolution of bats, a finding that supports the possibility of multiple origins of echolocation. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Toledo, Dept Psychol, Toledo, OH 43606 USA.
RP Heffner, RS (reprint author), Univ Toledo, Dept Psychol, Toledo, OH 43606 USA.
EM Rickye.Heffner@utoledo.edu
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NR 71
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 17
EP 25
DI 10.1016/j.heares.2006.06.008
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700002
PM 16982165
ER
PT J
AU Langemann, U
Klump, GM
AF Langemann, Ulrike
Klump, Georg M.
TI Asymmetry of masking in the European starling: Behavioural auditory
thresholds
SO HEARING RESEARCH
LA English
DT Article
DE bird; signal detection in narrow-band noise; intensity difference limen
(IDL); envelope spectrum; temporal processing
ID MODULATION TRANSFER-FUNCTIONS; EXCITATION-PATTERN MODEL;
AMPLITUDE-MODULATION; STURNUS-VULGARIS; INTENSITY DISCRIMINATION; NOISE;
BANDWIDTH; CARRIERS; LEVEL
AB Psychophysical studies of simultaneous masking with human observers exhibit an asymmetry in the amount of masking that depends on the relative bandwidths of signals and maskers. For noise bands up to the bandwidth of one auditory filter, masked auditory thresholds are considerably lower when the bandwidth of the signal exceeds that of the masker compared to the reversed condition. We investigate asymmetry of masking in an animal model, that will allow to study the mechanisms associated with the asymmetry of masking effect. European starlings (Sturnus vulgaris) were trained in a Go/NoGo paradigm to report the detection of a 500 ms noise signal centred in a 700 ms noise masker. Signals and maskers with centre frequencies of 2 kHz had bandwidths of 4 Hz or 256 Hz. Thresholds for detecting the 256 Hz wide-band signal in a 4 Hz narrow-band masker were considerably lower compared to detecting the 4 Hz narrow-band signal in a 256 Hz wide masker and compared to all other conditions. The asymmetry of masking in starlings was on average 15 and 17 dB for 40 and 70 dB SPL overall masker level, respectively. Our animal model thus proved perceptual abilities similar to human subjects. The results are discussed with respect to the importance of both intensity and temporal cues for signal detection. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Oldenburg, Fak 5, Inst Biol & Umweltwissensch, D-26129 Oldenburg, Germany.
RP Langemann, U (reprint author), Univ Oldenburg, Fak 5, Inst Biol & Umweltwissensch, Carl von Ossietzky Str 9-11, D-26129 Oldenburg, Germany.
EM ulrike.langemann@uni-oldenburg.de
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NR 40
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 26
EP 35
DI 10.1016/j.heares.2006.06.018
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700003
PM 16973317
ER
PT J
AU Kiefer, J
Bohnke, F
Adunka, O
Arnold, W
AF Kiefer, Jan
Boehnke, Frank
Adunka, Oliver
Arnold, Wolfgang
TI Representation of acoustic signals in the human cochlea in presence of a
cochlear implant electrode
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; inner ear; cochlear implant; basilar membrane; model;
electric-acoustic stimulation; frequency representation; round window;
impedance
ID AUDITORY-SYSTEM; HEARING-LOSS; STIMULATION; PRESERVATION; MEMBRANE
AB Background: In subjects with remaining low frequency hearing, combined electric-acoustic stimulation (EAS) of the auditory system is a new therapeutic perspective. Intracochlear introduction of a cochlear implant electrode, however, may alter the biomechanical properties of the inner ear and thus affect perception of acoustic stimuli.
Study design: Based on histological observations of morphologic changes after cochlear implantation in cadaveric and post mortem studies the effects of basilar membrane (BM) stiffening in the ascending basal and middle turns of the cochlea due to close contact of the BM with the electrode were simulated in a 3D-computational finite element model of the inner ear. To verify our simulated results, pre- and postoperative pure-tone audiograms of 13 subjects with substantial residual hearing, who underwent cochlear implantation, were evaluated.
Results: In the scenario of partial BM-fixation, acoustic energy of middle (2 kHz) and high (6 kHz) frequency was focused basally and apically to the fixed section, increasing BM displacement amplitudes up to 6 dB at a stimulation level of 94 dB (SPL). Lower frequencies were not affected by fixation in the basal and middle turn of the cochlea. In implanted subjects, a small but significant decrease of thresholds was observed at 1.5 kHz, a place in tonotopy adjacent to the tip region of the implanted electrode.
Conclusion: Our model suggests that stiffening of the basilar membrane adjacent to an implanted electrode into the basal and middle cochlear turn did not affect BM movement in the low frequency area. Focussing of acoustic energy may increase perception in regions adjacent to the fixed section. Observations in implanted subjects were concordant with our model predictions. High frequencies, however, should not be amplified in patients using EAS to avoid disturbances in discrimination due to tonotopically incorrect frequency representation. (c) 2006 Published by Elsevier B.V.
C1 Tech Univ Munich, Klinikum Rechts Isar, Klin & Poliklin HNO Heilkunde, Dept Otolaryngol, D-81675 Munich, Germany.
Univ N Carolina, Dept Otolaryngol, Chapel Hill, NC USA.
RP Kiefer, J (reprint author), Tech Univ Munich, Klinikum Rechts Isar, Klin & Poliklin HNO Heilkunde, Dept Otolaryngol, Ismaninger Str 22, D-81675 Munich, Germany.
EM J.Kiefer@lrz.tum.de
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NR 16
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 36
EP 43
DI 10.1016/j.heares.2006.07.013
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700004
PM 16962268
ER
PT J
AU Calderon, A
Derr, A
Stagner, BB
Johnson, KR
Martin, G
Noben-Trauth, K
AF Calderon, Alfredo
Derr, Adam
Stagner, Barden B.
Johnson, Kenneth R.
Martin, Glen
Noben-Trauth, Konrad
TI Cochlear developmental defect and background-dependent hearing
thresholds in the Jackson circler (jc) mutant mouse
SO HEARING RESEARCH
LA English
DT Article
DE Jackson circler; hearing loss; vestibular deficits; cochlea
malformation; genetic background
ID PRODUCT OTOACOUSTIC EMISSIONS; ENLARGED VESTIBULAR AQUEDUCT; BRAIN-STEM
RESPONSE; INNER-EAR; PENDRED-SYNDROME; MODIFIER GENES; JERKER MOUSE;
MICE; STEREOCILIA; MUTATIONS
AB Jackson circler (jc) is a spontaneous, recessive mouse mutation that results in circling behavior and an impaired acoustic startle response. In this study, we refined the phenotypic and genetic parameters of the original jc mutation and characterized a new mutant allele, jc(2J). In open-field behavior tests, homozygous jc mutants exhibited abnormal circling and ambulatory behavior that was indistinguishable from that of phenotypically similar mutants with defects in the vestibule of the inner ear. The jc/jc and jc(2J)/jc(2J) mice had stable elevated auditory-evoked brainstem response (ABR) thresholds at the 16 kHz stimulus of 88 +/- 9 dB sound pressure levels (SPL) and 43 +/- 11 dB SPL, respectively. Peak latencies and peak time intervals were normal in jc mutants. The jc mice showed no measurable distortion-product otoacoustic emissions (DPOAEs) above the system noise floor. In the mutant cochlea, the apical turn failed to form due to the developmental growth arrest of the cochlear duct at the level of the first turn at gestational day 13.5. In a large intrasubspecific intercross, jc localized to a 0.2cM interval at position 25cM on chromosome 10, which is homologous to the human 6q21 region. On CZECHII/Ei and CAST/Ei backgrounds jc/jc mutant hearing thresholds at the 16 kHz stimulus were significantly lower than those observed on the C57BL/6J background, with means of 62 +/- 22 dB SPL and 55 +/- 18 dB SPL, respectively. Genome-wide linkage scans of backcross, intercross, and congenic progeny revealed a complex pattern of genetic and stochastic effects. (c) 2006 Elsevier B.V. All rights reserved.
C1 NIDOCD, Neurogenet Sect, Inst Mol Biol, Rockville, MD 20850 USA.
Jerry L Pettis Mem Vet Adm Med Ctr, Loma Linda, CA 92357 USA.
Jackson Lab, Bar Harbor, ME 04609 USA.
RP Noben-Trauth, K (reprint author), NIDOCD, Neurogenet Sect, Inst Mol Biol, 5 Res Court, Rockville, MD 20850 USA.
EM nobentk@nidcd.nih.gov
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NR 60
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 44
EP 58
DI 10.1016/j.heares.2006.07.008
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700005
PM 16962269
ER
PT J
AU Konig, O
Schaette, R
Kempter, R
Gross, M
AF Koenig, Ovidiu
Schaette, Roland
Kempter, Richard
Gross, Manfred
TI Course of hearing loss and occurrence of tinnitus
SO HEARING RESEARCH
LA English
DT Article
DE tinnitus; noise-induced hearing loss; audiometric difference; audiogram
steepness; audiogram edge; tinnitus pitch
ID DORSAL COCHLEAR NUCLEUS; ENRICHED ACOUSTIC ENVIRONMENT; PURE-TONE
TRAUMA; FREQUENCY DISCRIMINATION; AUDITORY-CORTEX; PLASTICITY; DAMAGE;
HYPERACTIVITY; PREVALENCE; EXPOSURE
AB Chronic tinnitus is often accompanied by a hearing impairment, but it is still unknown whether hearing loss can actually cause tinnitus. The association between the pitch of the tinnitus sensation and the audiogram edge in patients with high-frequency hearing loss suggests a functional relation, but a large fraction of patients with hearing loss does not present symptoms of tinnitus. We therefore, investigated how the occurrence of tinnitus is related to the shape of the audiogram. We analyzed a sample where all patients had noise-induced hearing loss, containing 30 patients without tinnitus, 24 patients with tone-like tinnitus, and 17 patients with noise-like tinnitus. All patients had moderate to severe high-frequency hearing loss, and only minor to moderate hearing loss at low frequencies. We found that tinnitus patients had less overall hearing loss than patients without tinnitus. Moreover, the maximum steepness of the audiogram was higher in patients with tinnitus (-52.9 +/- 1.9 dB/octave) compared to patients without tinnitus (-43.1 +/- 2.4 dB/octave). Differences in overall hearing loss and maximum steepness between tone-like and noise-like tinnitus were not significant. For tone-like tinnitus, there was a clear association between the tinnitus pitch and the edge of the audiogram, with tinnitus pitch being on average 1.48 +/- 0.12 octaves above the audiogram edge frequency, and 0.81 +/- 0.1 octaves above the frequency with the steepest slope. Our results suggest that the occurrence of tinnitus is promoted by a steep audiogram slope. A steep slope leads to abrupt discontinuities in the activity along the tonotopic axis of the auditory system, which could be misinterpreted as sound. (c) 2006 Elsevier B.V. All rights reserved.
C1 Humboldt Univ, Inst Theroret Biol, D-10115 Berlin, Germany.
Med Fac Berlin, Charite, Dept Audiol & Phoniatr, D-14195 Berlin, Germany.
Bernstein Ctr Computat Neurosci Berlin, D-10115 Berlin, Germany.
Med Fac Berlin, Charite, Ctr Res Neurosci, D-10117 Berlin, Germany.
RP Schaette, R (reprint author), Humboldt Univ, Inst Theroret Biol, Invalidenstr 43, D-10115 Berlin, Germany.
EM r.schaette@biologie.hu-berlin.de
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NR 36
TC 64
Z9 68
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 59
EP 64
DI 10.1016/j.heares.2006.07.007
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700006
PM 16962270
ER
PT J
AU Jones, SJ
AF Jones, S. J.
TI Cortical processing of quasi-periodic versus random noise sounds
SO HEARING RESEARCH
LA English
DT Article
DE auditory evoked potentials; auditory cortex; iterated rippled noise;
pitch onset response; temporal regularity
ID HUMAN AUDITORY-CORTEX; ITERATED RIPPLED NOISE; TONOTOPIC ORGANIZATION;
MAGNETIC-FIELDS; COMPLEX TONES; EVOKED POTENTIALS; PITCH;
REPRESENTATION; FREQUENCY; MAPS
AB The first objective was to confirm using auditory evoked potentials (AEPs) the findings of magnetoencephalographic studies; that quasi-periodic iterated rippled noise (IRN) elicits a population response in the human auditory cortex which is topographically distinct from that elicited by random noise with a similar overall frequency spectrum. AEPs were recorded at the onset of random noise from silence, at the transition from random noise to IRN with a period of 5 ms, and in the two complementary conditions, IRN onset from silence and the transition from IRN to random noise. An N1/P2 complex was recorded to all four stimuli, that to the transition to IRN being significantly the most anteriorly distributed on the scalp. The second objective was to determine whether the response to the transition to IRN was due to detection of its quasi-periodicity, rather than its spectral "ripples". Virtually no effect was found of applying a 2 kHz low- or high-pass filter, above which it is unlikely that the spectral ripples at intervals of 200 Hz would have been resolved on the cochlear partition. It is concluded that a substantial neuronal population in the auditory cortex is influenced by temporal regularity in sounds, and that this population is equally responsive to spectral frequencies below and above 2 kHz. (c) 2006 Elsevier B.V. All rights reserved.
C1 UCL Natl Hosp Neurol & Neurosurg, Dept Clin Neurophysiol, London WC1N 3BG, England.
RP Jones, SJ (reprint author), UCL Natl Hosp Neurol & Neurosurg, Dept Clin Neurophysiol, Queen Sq, London WC1N 3BG, England.
EM sjjones@ion.ucl.ac.uk
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NR 35
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 65
EP 72
DI 10.1016/j.heares.2006.06.019
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700007
PM 16963209
ER
PT J
AU Willott, JF
VandenBosche, J
Shimizu, T
Ding, DL
Salvi, R
AF Willott, James F.
VandenBosche, Justine
Shimizu, Toru
Ding, Da-Lian
Salvi, Richard
TI Effects of exposing gonadectomized and intact C57BL/6J mice to a
high-frequency augmented acoustic environment: Auditory brainstem
response thresholds and cytocochleograms
SO HEARING RESEARCH
LA English
DT Article
DE mouse; ABR; augmented acoustic environment; hearing loss; cochleograms;
hair cells; gonadal hormones; sex differences
ID ANTEROVENTRAL COCHLEAR NUCLEUS; PRODUCT OTOACOUSTIC EMISSIONS; AGING
C57BL-6J MICE; HAIR CELL LOSS; HEARING-LOSS; SEX-DIFFERENCES; DBA/2J
MICE; PROLONGED EXPOSURE; ESTROGEN-RECEPTORS; CALBINDIN D-28K
AB Gonadectomized and surgically intact adult C57BL/6J (B6) mice of both sexes were exposed for 12 h nightly to a high-frequency augmented acoustic environment (AAE): repetitive bursts of a half-octave noise band centered at 20 kHz, 70 dB SPL. The effects of sex, gonadectomy, and AAE treatment on genetic progressive hearing loss (exhibited by B6 mice) were evaluated by obtaining auditory brainstem response thresholds at ages 3-, 6-, and 9-months; hair cell counts (cytocochleograms) were obtained at 9 months. A sex difference in the rate of genetic progressive hearing loss in B6 mice (observed by earlier studies) was confirmed, with females exhibiting a faster rate of threshold elevations and more severe loss of hair cells at age 9 months. Gonadectomy had no consistent effects on the rate or severity of hearing loss in non-exposed mice of either sex. An unexpected finding was that the high-frequency AAE treatment caused additional ABR threshold elevations and hair cell loss. In an earlier study, the same high-frequency AAE treatment on DBA/2J mice ameliorated hearing loss. The most severe AAE-induced losses occurred in surgically intact females, suggesting a potentiating effect of ovarian hormone(s). (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ S Florida, Dept Psychol, Tampa, FL 33620 USA.
Jackson Lab, Bar Harbor, ME 04609 USA.
SUNY Buffalo, Dept Biochem, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Willott, JF (reprint author), Univ S Florida, Dept Psychol, 4202 E Fowler Ave,PCD4188G, Tampa, FL 33620 USA.
EM jimw@niu.edu
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NR 59
TC 7
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 73
EP 81
DI 10.1016/j.heares.2006.07.016
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700008
PM 16973316
ER
PT J
AU Chen, L
Sun, W
Salvi, RJ
AF Chen, Lin
Sun, Wei
Salvi, Richard J.
TI Effects of nimodipine, an L-type calcium channel antagonist, on the
chicken's cochlear potentials
SO HEARING RESEARCH
LA English
DT Article
DE L-type calcium channel; hair cell; neurotransmitter release; nimodipine;
chicken; cochlear potential
ID GUINEA-PIG COCHLEA; GATED CA2+ CHANNELS; ACTIVATED POTASSIUM CHANNELS;
SPIRAL GANGLION-CELLS; INNER HAIR-CELLS; TRANSMITTER RELEASE; DISCHARGE
PATTERNS; ALPHA(1D) SUBUNIT; SENSORY NEURONS; KAINIC ACID
AB At most synapses in the brain, neurotransmitter release depends on N-type or P/Q-type calcium channels. However, available in vitro experimental data suggest that there exist almost exclusively L-type calcium channels in sensory hair cells of most species. To test whether chicken hair cells depend on L-type calcium channels for neurotransmitter release, we examined the effects of nimodipine, a selective L-type calcium channel antagonist, on acoustically evoked cochlear potentials in 10-15 week old chickens in vivo. Diffusion of nimodipine into scala tympani significantly elevated threshold, dramatically decreased the amplitude and increased the latency of the compound action potential within 20 min of drug application. The summating potential was also significantly reduced in amplitude, but the cochlear microphonic was relatively less affected. All the effects were reversible after nimodipine was washed out with artificial perilymph except that the cochlear microphonic amplitude remained decreased. Application of omega-conotoxin GVIA, an N-type calcium channel antagonist and agatoxin Tk, a P-type calcium channel antagonist had no observable effects on the cochlear potentials. These results suggest that L-type calcium channels control neurotransmitter release from avian hair cells. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Sci & Technol China, Sch Life Sci, Auditory Res Lab, Hefei 230027, Peoples R China.
SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Chen, L (reprint author), Univ Sci & Technol China, Sch Life Sci, Auditory Res Lab, Hefei 230027, Peoples R China.
EM linchen@ustc.edu.cn
RI Chen, Lin/N-8327-2013
OI Chen, Lin/0000-0002-5847-2989
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NR 50
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 82
EP 90
DI 10.1016/j.heares.2006.08.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700009
PM 16996235
ER
PT J
AU Shechter, B
Depireux, DA
AF Shechter, Barak
Depireux, Didier A.
TI Response adaptation to broadband sounds in primary auditory cortex of
the awake ferret
SO HEARING RESEARCH
LA English
DT Article
DE auditory cortex; adaptation; grating; ferret; second-order adaptation;
coding; primary auditory cortex; AI
ID SPECTROTEMPORAL REVERSE CORRELATION; MODULATION TRANSFER-FUNCTIONS;
AMPLITUDE-MODULATION; CONTRAST ADAPTATION; RECEPTIVE-FIELDS; DYNAMIC
SPECTRA; UNIT RESPONSES; CAT; NEURONS; REPRESENTATION
AB Driven by previous reports of adaptation to persistent stimuli in other brain regions, we investigated adaptive effects in the Primary Auditory Cortex of awake non-behaving ferrets (Mustela putorius furo). Electrophysiological data was obtained in response to the presentation of auditory gratings with a structured spectro-temporal envelope of varying bandwidth which had repeated transitions between low and high modulation depths. The responses were analyzed in terms of the evoked spike rates and in terms of the degree of phase locking to the modulation. We found two populations of cells, both of which showed adaptation in the traditional sense. For one population, we also found a second order of adaptation -i.e., adaptation of the adaptation. This suggests the existence of at least two coding strategies which differ in the weight placed on sensory context. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Maryland, Dept Anat & Neurobiol, Sch Med, Baltimore, MD 21201 USA.
Univ Maryland, Program Neurosci, Sch Med, Baltimore, MD 21201 USA.
RP Shechter, B (reprint author), Univ Maryland, Dept Anat & Neurobiol, Sch Med, 20 Pennh St,HSF 2 Rm S251, Baltimore, MD 21201 USA.
EM bshec001@umaryland.edu
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NR 36
TC 12
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 91
EP 103
DI 10.1016/j.heares.2006.08.002
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700010
PM 16982164
ER
PT J
AU Stamataki, S
Francis, HW
Lehar, M
May, BJ
Ryugo, DK
AF Stamataki, Sofia
Francis, Howard W.
Lehar, Mohamed
May, Bradford J.
Ryugo, David K.
TI Synaptic alterations at inner hair cells precede spiral ganglion cell
loss in aging C57BL/6J mice
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; afferent innervation; synapse; ultrastructure; presbycusis
ID ANTEROVENTRAL COCHLEAR NUCLEUS; SENSORINEURAL HEARING-LOSS;
AUDITORY-NERVE FIBERS; AGE-RELATED LOSS; DEAF WHITE CATS; MOUSE MODEL;
DENDRITIC SPINES; SERIAL SECTIONS; FUNCTIONAL AGE; SYNAPSES
AB Hearing deficits have often been associated with loss of or damage to receptor hair cells and/or degeneration of spiral ganglion cells. There are, however, some physiological abnormalities that are not reliably attributed to loss of these cells. The afferent synapse between radial fibers of spiral ganglion neurons and inner hair cells (IHCs) emerges as another site that could be involved in transmission abnormalities. We tested the hypothesis that the structure of these afferent terminals would differ between young animals and older animals with significant hearing loss. Afferent endings and their synapses were examined by transmission electron microscopy at approximately 45% distance from the basal end of the cochlea in 2-3 month-old and 8-12 month-old C57BL/6J mice. The number of terminals in older animals was reduced by half compared to younger animals. In contrast, there was no difference in the density of SGCs between the age groups. Older animals featured enlarged terminals and mitochondria and enlarged postsynaptic densities and presynaptic bodies. These morphological changes may be a combination of pathologic, adaptive and compensatory responses to sensory dysfunction. Improved knowledge of these processes is necessary to understand the role of afferent connectivity in dysfunction of the aging cochlea. (c) 2006 Elsevier B.V. All rights reserved.
C1 Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA.
RP Francis, HW (reprint author), Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Johns Hopkins Outpatient Ctr, 601 N Caroline St,6th Floor, Baltimore, MD 21287 USA.
EM hfrancis@jhmi.edu
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NR 57
TC 38
Z9 44
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 104
EP 118
DI 10.1016/j.heares.2006.07.014
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700011
PM 17005343
ER
PT J
AU Sendowski, I
Abaamrane, L
Raffin, F
Cros, A
Clarencon, D
AF Sendowski, I.
Abaamrane, L.
Raffin, F.
Cros, A.
Clarencon, D.
TI Therapeutic efficacy of intra-cochlear administration of
methylprednisolone after acoustic trauma caused by gunshot noise in
guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE acoustic trauma; impulse noise; guinea pig; methylprednisolone; osmotic
pump
ID SENSORINEURAL HEARING-LOSS; INNER-EAR; GLUCOCORTICOID RECEPTORS;
STEROID-THERAPY; FREE-RADICALS; NITRIC-OXIDE; HAIR-CELLS; PREDNISOLONE;
PHARMACOKINETICS; AGENTS
AB The therapeutic efficacy of cochlear infusion of methylprednisolone (MP) after an impulse noise trauma (170 dB SPL peak) was evaluated in guinea pigs. The compound action potential threshold shifts were measured over a 14 days recovery period after the gunshot exposure. For each animal, one of the cochlea was perfused directly into the scala tympani with MP during 7 days via a mini-osmotic pump, whereas the other cochlea was not pump-implanted. The functional study of hearing was supplemented by histological analysis. Forty eight hours after the trauma, significant differences between auditory threshold shifts in the implanted and non-implanted ears were observed for frequencies above 8 kHz. At day 7, the difference was significant for only one frequency and no difference was observed after 14 days recovery. Cochleograms showed that the hair cell losses were significantly lower in the MP treated ears. This work indicates that direct infusion of MP into perilymphatic space accelerates hearing recovery, reduces hair cell losses after impulse noise trauma but does not limit permanent threshold shifts. (c) 2006 Elsevier B.V. All rights reserved.
C1 CRSSA, Dept Radiobiol, F-38702 La Tronche, France.
RP Sendowski, I (reprint author), CRSSA, Dept Radiobiol, 24 Ave Maquis Gresivaudan,BP 87, F-38702 La Tronche, France.
EM isendowski@crssa.net; L.abaamrane@crssa.net; Fraffin@crssa.net;
Didierclarencon@crssa.net
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NR 60
TC 23
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 119
EP 127
DI 10.1016/j.heares.2006.08.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700012
PM 17008037
ER
PT J
AU Sugahara, K
Rubel, EW
Cunningham, LL
AF Sugahara, Kazuma
Rubel, Edwin W.
Cunningham, Lisa L.
TI JNK signaling in neomycin-induced vestibular hair cell death
SO HEARING RESEARCH
LA English
DT Article
DE hair cell; aminoglycoside; JNK; caspase; apoptosis; ototoxicity; utricle
ID TERMINAL KINASE PROTECTS; C-JUN; IN-VITRO; SENSORY EPITHELIA; NEURONAL
APOPTOSIS; CASPASE ACTIVATION; PEPTIDE INHIBITOR; GENTAMICIN;
AMINOGLYCOSIDE; PATHWAYS
AB Mechanosensory hair cells are susceptible to apoptotic death in response to exposure to ototoxic drugs, including aminoglycoside antibiotics. The c-Jun n-terminal kinase (JNK) is a stress-activated protein kinase that can promote apoptotic cell death in a variety of systems. Inhibition of the JNK signaling pathway can prevent aminoglycoside-induced death of cochlear and vestibular sensory hair cells. We used an in vitro preparation of utricles from adult mice to examine the role of JNK activation in aminoglycoside-induced hair cell death. CEP-11004 was used as an indirect inhibitor of JNK signaling. Immunohistochemistry showed that both JNK and its downstream target c-Jun are phosphorylated in hair cells of utricles exposed to neomycin. CEP-11004 inhibited neomycin-induced phosphorylation of both JNK and c-Jun. CEP-11004 inhibited hair cell death in utricles exposed to moderate doses of neomycin. However, the results were not uniform across the dose-response function; CEP-11004 did not inhibit hair cell death in utricles exposed to high-dose neomycin. The CEP-11004-induced protective effect was not due to inhibition of PKC or p38, since neither Chelerythrine nor SB203580 could mimic the protective effect of CEP-11004. In addition, inhibition of JNK inhibited the activation of caspase-9 in hair cells. These results indicate that JNK plays an important role in neomycin-induced vestibular hair cell death and caspase-9 activation. (c) 2006 Elsevier B.V. All rights reserved.
C1 Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA.
Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
Yamaguchi Univ, Sch Med, Dept Otolaryngol, Ube, Yamaguchi 7550585, Japan.
RP Cunningham, LL (reprint author), Med Univ S Carolina, Dept Pathol & Lab Med, Box 250908, Charleston, SC 29425 USA.
EM cunninll@musc.edu
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NR 43
TC 28
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2006
VL 221
IS 1-2
BP 128
EP 135
DI 10.1016/j.heares.2006.08.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 105RT
UT WOS:000242050700013
PM 17005344
ER
PT J
AU Choudhury, N
Song, GJ
Chen, FY
Matthews, S
Tschinkel, T
Zheng, JF
Jacques, SL
Nuttall, AL
AF Choudhury, Niloy
Song, Guiju
Chen, Fangyi
Matthews, Scott
Tschinkel, Tanja
Zheng, Jiefu
Jacques, Steven L.
Nuttall, Alfred L.
TI Low coherence interferometry of the cochlear partition
SO HEARING RESEARCH
LA English
DT Article
ID BASILAR-MEMBRANE VIBRATION; GUINEA-PIG COCHLEA; HETERODYNE LASER
INTERFEROMETER; MOSSBAUER TECHNIQUE; CAPACITIVE PROBE; RECORDING DEPTH;
INNER-EAR; TOMOGRAPHY; MOTION
AB Interferometric measurement of the vibration of the organ of Corti in the isolated guinea pig cochlea was conducted using low-coherence light (1310 +/- 47 nm wavelength) from a superluminescent diode. The short coherence length of the light source localized measurements along the axial direction to within a similar to 10-mu m window (in tissue), even when using a low numerical-aperture lens. The ability to accomplish this is important because measurement of the vibration of the basal-turn organ of Corti is generally done via a small hole in the bone of the cochlea, which effectively limits the numerical aperture. The axial localization, combined with the inherent sensitivity of the method, allowed distinct measurements of the basilar membrane (BM) and the putative reticular lamina (RL) vibration using only the native tissue reflectance, that is without requiring the use of reflective particles. The system was first operated in a scanning mode as an optical coherence tomography (OCT) system to yield an image of the organ of Corti. The reflectance of intensity from the BM and RL was 8 x 10(-5) and 8 x 10(-6), respectively. The internal structure between the BM and RL presented a variable reflectivity of about 10(-7). A mirror would define a reflectance of 1.00. Then the instrument was operated as a homodyne interferometer to measure the displacement of either the BM or RL. Vibration at 16 kHz was induced by a piezoelectric actuator, causing whole movement of a dissected cochlea. After calibration of the system, we demonstrated clear measurement of mechanically driven vibration for both the BM and RL of 0.30 nm above a noise floor equivalent to 0.03 nm. OCT interferometry, when adapted for in vivo organ of Corti measurements, appears suitable to determine the micromechanical vibration of cells and tissue elements of the organ. (c) 2006 Elsevier B.V. All rights reserved.
C1 Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
Oregon Hlth & Sci Univ, Beaverton, OR 97006 USA.
Univ Appl Sci, Tech Fach Hsch Berlin, D-13353 Berlin, Germany.
Oregon Hlth & Sci Univ, Dept Dermatol, Portland, OR 97239 USA.
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Shanghai Jiao Tong Univ, Dept Otolaryngol, Shanghai 200030, Peoples R China.
RP Nuttall, AL (reprint author), Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd,NRC04, Portland, OR 97239 USA.
EM nuttall@ohsu.edu
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NR 31
TC 32
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2006.06.006
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800001
PM 16945496
ER
PT J
AU Ohlemiller, KK
Lett, JM
Gagnon, PM
AF Ohlemiller, Kevin K.
Lett, Jadynn M.
Gagnon, Patricia M.
TI Cellular correlates of age-related endocochlear potential reduction in a
mouse model
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; stria vascularis; spiral ligament; marginal cells; intermediate
cells; basal cells; fibrocytes; presbycusis
ID SENSORINEURAL HEARING-LOSS; SPIRAL LIGAMENT PATHOLOGY; PIGMENTED
GUINEA-PIGS; COCHLEAR LATERAL WALL; STRIA VASCULARIS; INNER-EAR;
SUPEROXIDE-DISMUTASE; MRL-FAS(LPR) MOUSE; C57-B16 MOUSE; ROUND WINDOW
AB Age-related degeneration of cochlear stria vascularis and resulting reduction in the endocochlear potential (EP) are the hallmark features of strial presbycusis, one of the major forms of presbycusis, or age-related hearing loss (ARHL) (Schuknecht, H.F., 1964. Further observations on the pathology of presbycusis. Archives of Otolaryugology 80, 369-382; Schuknecht, H.F., 1993. Pathology of the Ear. Lea and Febiger, Philadelphia; Schuknecht, H.F., Gacek, M.R., 1993. Cochlear pathology in presbycusis. Annals of Otology, Rhinology and Laryngology 102, 1-16). It is unclear whether there are multiple forms of strial ARHL having different sequences of degenerative events and different risk factors. Human temporal bone studies suggest that the initial pathology usually affects strial marginal cells, then spreads to other strial cell types. While inheritance studies support a moderate genetic influence, no contributing genes have been identified. Establishment of mouse models of strial ARHL may promote the identification of underlying genes and gene/environment interactions. We have found that BALB/cJ mice show significant EP reduction by 19 months of age. The reduction only occurs in a subset of animals. To identify key anatomical correlates of the EP reduction, we compared several cochlear lateral wall metrics, in BALBs with those in C57BL/6J (136) mice, which show little EP reduction for ages up to 26 months. Among the measures obtained, marginal cell density and spiral ligament thickness were the best predictors of both the EP decline in BALBs, and EP stability in B6. Our results indicate that the sequence of strial degeneration in BALBs is like that suggested for humans. Additional strain comparisons we have performed suggest that genes governing strial melanin production do not play a role. (c) 2006 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Ohlemiller, KK (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, 660 S Euclid, St Louis, MO 63110 USA.
EM kohlemiller@wustl.edu
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NR 76
TC 32
Z9 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 10
EP 26
DI 10.1016/j.heares.2006.06.012
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800002
PM 16901664
ER
PT J
AU Otto, G
Ingo, H
Malte, KC
Georg, K
Jurgen, S
AF Otto, Gleich
Ingo, Hamann
Malte, Kittel C.
Georg, Klump M.
Juergen, Strutz
TI A quantitative analysis of psychometric functions for different auditory
tasks in gerbils
SO HEARING RESEARCH
LA English
DT Article
DE presbyacusis; aging; hearing loss; psychoacoustic testing; temporal
processing; gap detection
ID QUIET-AGED GERBILS; MERIONES-UNGUICULATUS; MONGOLIAN GERBIL; GAP
DETECTION; NORMAL-HEARING; NERVE FIBERS; NOISE; THRESHOLDS; MASKING;
YOUNG
AB The psychometric function relates the probability of a correct response to the variation of a physical stimulus parameter. In many perceptual tasks one point on this function is defined by a more or less arbitrary threshold criterion and threshold is used to study the effects of various treatments or age. Besides threshold, the shape of the psychometric function provides additional information. The variability of internal (neural) noise and the sensorineural transduction function will affect the shape of the psychometric function and may, therefore, reveal important features in the processing of stimulus characteristics. Here we analyze the effect of age on psychometric functions from gerbils: (A) for the detection of a tone or noise pulse in silence which is generally regarded as a measure of cochlear function and (B) for a gap detection task, investigating aspects of temporal processing that involve the ascending auditory pathway. Our data show that the slope of the psychometric function for the detection of tone and noise pulses in silence is independent of age and threshold. In contrast, the steepness of the psychometric function is decreased in gerbils with impaired temporal resolution. We discuss these observations in the context of physiological data from young and old animals. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Regensburg, ENT Dept, D-93042 Regensburg, Germany.
Univ Oldenburg, AG Zoophysiol & Verhalten, Inst Biol & Umweltwissensch, D-26111 Oldenburg, Germany.
RP Otto, G (reprint author), Univ Regensburg, ENT Dept, Franz Josef Str Allee 11, D-93042 Regensburg, Germany.
EM otto.gleich@klinik.uni-regensburg.de; ingo-kva@online.no;
Matte.Kittel@astrazeneca.com; juergen.strutz@Klinik.uni-regensburg.de;
juergen.strutz@klinik.uni-regensburg.de
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NR 35
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 27
EP 37
DI 10.1016/j.heares.2006.06.014
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800003
ER
PT J
AU MacLennan, AJ
Benner, SJ
Andringa, A
Chaves, AH
Rosing, JL
Vesey, R
Karpman, AM
Cronier, SA
Lee, N
Erway, LC
Miller, ML
AF MacLennan, A. John
Benner, Shannon J.
Andringa, Anastasia
Chaves, Alicia H.
Rosing, Joanna L.
Vesey, Rachel
Karpman, Adam M.
Cronier, Samantha A.
Lee, Nancy
Erway, Larry C.
Miller, Marian L.
TI The S1P(2) sphingosine 1-phosphate receptor is essential for auditory
and vestibular function
SO HEARING RESEARCH
LA English
DT Article
DE ear; lysophospholipid; AGR16; H218; Edg-5; vestibular
ID SMOOTH-MUSCLE-CELLS; PROTEIN-COUPLED RECEPTORS; SIGNALING PATHWAYS;
MAMMALIAN-CELLS; CALCIUM SIGNALS; MUTANT MICE; SPHINGOSINE-1-PHOSPHATE;
EDG3; MIGRATION; HEARING
AB Sphingosine I-phosphate (SIP) is an endogenous growth factor with potent effects on many different cell types. Most of these effects are produced by activation of one or more of a family of G-protein coupled receptors. The S1P(2) receptor can mediate SIP-induced proliferation, differentiation and survival in a wide variety of cells in culture. However, identifying essential in vivo functions for S1P2 has been hampered by its ubiquitous expression and the failure to detect any anatomical abnormalities in initial analyses Of S1P(2) knockout mice. We report here that all S1P(2) knockout mice are profoundly deaf from postnatal day 22 and approximately half display a progressive loss of vestibular function with aging. Anatomically, both the auditory and vestibular systems appear to develop normally but then degrade. Morphological defects associated with hearing are first detected at 3 weeks postnatal as deformations of the organ of Corti/Nuel's space. By one year of age structures within the scala media are dramatically altered. The S1P(2) knockout mice also display a loss of otoconia consistent with the vestibular impairment. The present data are the first to indicate that SIP signaling plays critical roles, in vivo, in auditory and vestibular functions. The data further establish that the SIP signaling occurs through the S1P(2) receptor and makes an essential. contribution to the structural maintenance of these systems, raising the possibility that properly targeted enhancement of this signaling may prove to be clinically beneficial. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Cincinnati, Dept Cellular & Mol Physiol, Cincinnati, OH 45267 USA.
Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45267 USA.
Univ Florida, Dept Neurosci, Gainesville, FL 32610 USA.
Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA.
RP MacLennan, AJ (reprint author), Univ Cincinnati, Dept Cellular & Mol Physiol, 231 Albert Sabin Way,Room 4155 MSB, Cincinnati, OH 45267 USA.
EM john.maclen@uc.edu
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NR 43
TC 44
Z9 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 38
EP 48
DI 10.1016/j.heares.2006.06.016
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800004
PM 16945494
ER
PT J
AU van Wieringen, A
Carlyon, RP
Macherey, O
Wouters, J
AF van Wieringen, Astrid
Carlyon, Robert P.
Macherey, Olivier
Wouters, Jan
TI Effects of pulse rate on thresholds and loudness of biphasic and
alternating monophasic pulse trains in electrical hearing
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implants; pulse shape; rate; alternating monophasic
ID COCHLEAR-IMPLANT USERS; PSYCHOPHYSICAL DETECTION THRESHOLDS;
AUDITORY-NERVE; PHASE DURATION; STIMULATION; SENSITIVITY; SEPARATION;
FREQUENCY; GAP
AB Detection thresholds and most comfortable loudnesses (MCLs) were determined as a function of pulse rate for standard biphasic pulse trains (BP) and for anodic and cathodic monophasic phases alternating at fixed intervals (ALT-m). Three different phase durations were examined.
With a 100-mu s phase duration, thresholds for the ALT-m stimulus were substantially (up to 12 dB) lower than for the BP stimuli at relatively low rates (200 pps), but were similar to the BP thresholds at high rates (>= 1000 pps). Thresholds for BP pulse trains decreased monotonically with increasing rate, whereas the function for ALT-m waveforms was non-monotonic with a maximum between 400 and 1000 pps. These trends occurred for three different cochlear implant devices, different electrode configurations, and, generally, for different phase durations (10.8,25, and 100 mu s/phase). However, at the shorter phase durations, thresholds remained lower for the ALT-m stimulus, even at 5000 pps, the highest rate studied.
Dynamic ranges of the BP pulse trains increased with increasing rate, irrespective of the phase duration under test, but for the ALT-m stimuli this was only true at the shorter phase durations tested. At a 100-mu s phase duration, dynamic ranges for the ALT-m waveforms did not differ significantly as a function of rate.
The results confirm previous reports that delaying charge recovery, in this case by switching from a BP to an ALT-m wave shape, can substantially reduce thresholds [Van Wieringen, A., Carlyon, R.P., Laneau, J., Wouters, J., 2005. Effects of waveform shape on human sensitivity to electrical stimulation of the inner ear. Hear. Res. 200, 73-86; Carlyon, R.P., van Wieringen, A., Decks, J.M., Long, C.J., Lyzenga, J, Wouters, J., 2005. Effect of inter-phase gap on the sensitivity of cochlear implant users to electrical stimulation. Hear. Res. 205, 210224]. However, at high pulse rates, this advantage only occurs at short phase durations. In addition, we show that the complex interaction between the effects of pulse shape, rate, and phase duration on thresholds can be captured by the simple linear model described by Carlyon et al. (c) 2006 Elsevier B.V. All rights reserved.
C1 Katholieke Univ Leuven, Dept Neurosci, ExpORL, B-3000 Louvain, Belgium.
MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England.
RP van Wieringen, A (reprint author), Katholieke Univ Leuven, Dept Neurosci, ExpORL, Herestr 49, B-3000 Louvain, Belgium.
EM astrid.vanwieringen@med.kuleuven.be
RI Carlyon, Robert/A-5387-2010; Wouters, Jan/D-1800-2015
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NR 32
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 49
EP 60
DI 10.1016/j.heares.2006.06.015
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800005
PM 16904278
ER
PT J
AU Dixit, A
Vaney, N
Tandon, OP
AF Dixit, Abhinav
Vaney, Neelam
Tandon, O. P.
TI Effect of caffeine on central auditory pathways: An evoked potential
study
SO HEARING RESEARCH
LA English
DT Article
DE auditory brainstem response; mid latency response; slow vertex response;
peak latency; interpeak latency
ID SELECTIVE ATTENTION; BRAIN; PERFORMANCE; RESPONSES; GENERATORS;
RECEPTORS; CAT; EEG
AB Caffeine is consumed in various forms like tea, coffee, chocolates and colas. The present study evaluated the effect of caffeine on auditory brainstem response (ABR), mid latency response (MLR) and slow vertex response (SVR) in 40 male volunteers. The recordings were done using a computerized evoked potential recorder by 10-20 electrode placement system. The subjects consumed 3 mg/kg body weight of caffeine after 12 It abstinence from caffeine in any form. The data obtained revealed that latencies of waves IV and V along with I-V interpeak interval of ABR decreased significantly. This was accompanied with significant increase in amplitude of wave V. MLR latencies and latency of PI wave of SVR was significantly decreased following caffeine ingestion. The results indicated that caffeine improves transmission in the peripheral and central brain auditory pathways. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Coll Med Sci, Dept Physiol, New Delhi 110095, India.
GTB Hosp, New Delhi 110095, India.
RP Dixit, A (reprint author), Near Vet Hosp, Moti Bagh 1, New Delhi 110021, India.
EM abhinavdr@yahoo.com; neelamvaney@rediffmail.com; optandon@hotmaii.com
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NR 39
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 61
EP 66
DI 10.1016/j.heares.2006.06.017
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800006
PM 16914275
ER
PT J
AU Meenderink, SWF
Narins, PM
AF Meenderink, Sebastiaan W. F.
Narins, Peter M.
TI Stimulus frequency otoacoustic emissions in the Northern leopard frog,
Rana pipiens pipiens: Implications for inner ear mechanics
SO HEARING RESEARCH
LA English
DT Article
DE stimulus frequency otoacoustic emissions; frog; Amphibian; linear
coherent reflection; nonlinear distortion
ID AMPHIBIAN PAPILLA; TEMPERATURE-DEPENDENCE; COCHLEA
AB Otoacoustic emissions (OAEs) are weak sounds that originate from the inner ear which are traditionally classified/named based on their evoking stimulus. Recently, it has been argued that such a classification, at least for mammals, misrepresents the underlying mechanisms of emission-generation. As an alternative classification, it has been suggested to recognize that OAEs arise either via nonlinear distortion or linear coherent reflection. For non-mammalian vertebrates, data on evoked OAEs that arise via the latter mechanism are largely missing. Here, we present the first measurements of stimulus frequency OAEs (SFOAEs), which are emissions thought to arise via linear coherent reflection, from an amphibian (the Northern leopard frog, Rana pipiens pipiens). Their properties as a function of the evoking stimulus frequencies and levels are described and subsequently compared with the previously reported properties of distortion product OAEs (DPOAEs) from the same frog species. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
RP Meenderink, SWF (reprint author), Univ Calif Los Angeles, Dept Physiol Sci, 621 Charles E Young Dr S, Los Angeles, CA 90095 USA.
EM swfmeenderink@yahoo.com
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NR 29
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 67
EP 75
DI 10.1016/j.heares.2006.07.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800007
PM 16942850
ER
PT J
AU Kermany, MH
Parker, LL
Guo, YK
Miller, D
Swanson, DJ
Yoo, TJ
Goldowitz, D
Zuo, J
AF Kermany, Mohammad Habiby
Parker, Lisan L.
Guo, Yun-Kal
Miller, Darla
Swanson, Douglas J.
Yoo, Tai-June
Goldowitz, Dan
Zuo, Jian
TI Identification of 17 hearing impaired mouse strains in the TMGC
ENU-mutagenesis screen
SO HEARING RESEARCH
LA English
DT Article
DE presbycusis; noise-induced hearing loss (NIHL); auditory brainstern
response (ABR); fibrocyte; ganglia; mouse; mutant
ID ETHYL-N-NITROSOUREA; GENOME-WIDE; MICE; OTOTOXICITY; INHERITANCE;
CADHERIN-23; DEAFNESS; MUTANTS; COCHLEA; LOCUS
AB The Tennessee Mouse Genome Consortium (TMGC) employed an N-ethyl-N-nitrosourea (ENU)-mutagenesis scheme to identify mouse recessive mutants with hearing phenotypes. We employed auditory brainstem responses (ABR) to click and 8, 16, and 32 kHz stimuli and screened 285 pedigrees (1819 mice of 8-11 weeks old in various mixed genetic backgrounds) each bred to carry a homozygous ENU-induced mutation. To define mutant pedigrees, we measured >= 12 mice per pedigree in >= 2 generations and used a criterion where the mean ABR threshold per pedigree was two standard deviations above the mean of all offspring from the same parental strain. We thus identified 17 mutant pedigrees (6%), all exhibiting hearing loss at high frequencies (>= 16 kHz) with an average threshold elevation of 30-35 dB SPL. Interestingly, four mutants showed sex-biased hearing loss and six mutants displayed wide range frequency hearing loss. Temporal bone histology revealed that six of the first nine mutants displayed cochlear morphological defects: degeneration of spiral ganglia, spiral ligament fibrocytes or inner hair cells (but not outer hair cells) mostly in basal turns. In contrast to other ENU-mutagenesis auditory screens, our screen identified high-frequency, mild and sex-biased hearing defects. Further characterization of these 17 mouse models will advance our understanding of presbycusis and noise-induced hearing loss in humans. (c) 2006 Elsevier B.V. All rights reserved.
C1 St Jude Childrens Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA.
Inst Neurosci, Dept Otolaryngol, Dept Mol Sci, Dept Med, Memphis, TN 38163 USA.
Oak Ridge Natl Lab, Div Life Sci, Oak Ridge, TN 37831 USA.
Univ Tennessee, Ctr Hlth Sci, Dept Anat & Neurobiol, Memphis, TN 38163 USA.
RP Zuo, J (reprint author), St Jude Childrens Hosp, Dept Dev Neurobiol, 332 N Lauderdale St, Memphis, TN 38105 USA.
EM jian.zuo@stjude.org
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NR 30
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 76
EP 86
DI 10.1016/j.heares.2006.07.011
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800008
PM 16949226
ER
PT J
AU Deng, YQ
Chen, YY
Reuss, L
Altenberg, GA
AF Deng, Yanqin
Chen, Yongyue
Reuss, Luis
Altenberg, Guillermo A.
TI Mutations of connexin 26 at position 75 and dominant deafness: Essential
role of arginine for the generation of functional gap-junctional
channels
SO HEARING RESEARCH
LA English
DT Article
DE Cx26; hemichannels; gap junction; aromatic amino acids; skin disease;
genetic disease
ID NONJUNCTIONAL PLASMA-MEMBRANE; NONSYNDROMIC HEARING-LOSS; INNER-EAR;
XENOPUS-OOCYTES; PALMOPLANTAR KERATODERMA; CHEMICAL RESCUE; METABOLIC
INHIBITION; EXTRACELLULAR LOOP; MOLECULAR-GENETICS; R75Q MUTATION
AB Gap-junctional channels are large intercellular aqueous pores formed by head-to-head association of two gap-junctional hemichannels (connexin hexamers), one from each of the adjacent cells. The mechano-transduction of sound waves into electrical impulses occurs in the cochlea, which houses the organ of Corti. Hereditary deafness is frequent and mutations of connexin 26, the predominant connexin of the cochlea, are its most frequent cause. Mutations of R75 cause deafness and disrupt gap-junctional communication. Here, we determined the effects of substitutions of R75 with different residues (alanine, asparagine, aspartic acid, lysine, phenylalanine, tyrosine or tryptophan) on formation of gap-junctional channels and hemichannels. We show that connexin 26 R75 is essential for the formation of gap-junctional channels. Substitution of R75 with aromatic residues yields functional hemichannels that display altered voltage dependence, whereas substitution with other residues yields non-functional hemichannels. The expression of R75 mutants has a dominant negative effect on gap-junctional communication mediated by wild-type connexin 26, independently of the ability of the mutants to form functional gap-junctional hemichannels. Our results show that the arginine located at position 75 of connexin 26 is essential for function, and cannot be replaced by other residues. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Texas, Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA.
Univ Texas, Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA.
RP Altenberg, GA (reprint author), Univ Texas, Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA.
EM galtenbe@utmb.edu
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NR 52
TC 15
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 87
EP 94
DI 10.1016/j.heares.2006.07.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800009
PM 16945493
ER
PT J
AU Xu, H
Wang, W
Tang, ZQ
Xu, TL
Chen, L
AF Xu, Han
Wang, Wei
Tang, Zheng-Quan
Xu, Tian-Le
Chen, Lin
TI Taurine acts as a glycine receptor agonist in slices of rat inferior
colliculus
SO HEARING RESEARCH
LA English
DT Article
DE taurine; glycine receptor; central nucleus of inferior colliculus; brain
slice; rat; whole-cell patch-clamp
ID NEUROTRANSMITTER AMINO-ACIDS; FOCAL CEREBRAL-ISCHEMIA;
CENTRAL-NERVOUS-SYSTEM; GABA-A RECEPTOR; OLFACTORY-BULB;
ELECTRICAL-STIMULATION; DEVELOPMENTAL-CHANGES; GABAERGIC INHIBITION;
CALCIUM HOMEOSTASIS; AUDITORY-SYSTEM
AB Taurine is an important endogenous amino acid for neural development and for many physiological functions,but little is known about its functional role in the central auditory system. We investigated in young rats (P10-P14) the effects of taurine on the neuronal responses and synaptic transmissions in the central nucleus of the inferior colliculus (ICC) with a brain slice preparation and with whole-cell patch-clamp recordings. Perfusion of taurine at I mM reliably evoked a current across the membrane and decreased the input resistance in neurons of the ICC. Taurine also depressed the spontaneous and current-evoked firing of ICC neurons. All these effects were reversible after washout and could be blocked by 3 mu M strychnine, an antagonist of glycine receptors, but not by 10 mu M bicuculline, an antagonist of GABA(A) receptors. When the inhibitory receptors were not pharmacologically blocked, taurine reversibly reduced the postsynaptic currents/potentials evoked by electrically stimulating the commissure of the inferior colliculus or the ipsilateral lateral lemniscus. The results demonstrate that taurine reduces the neuronal excitability and depresses the synaptic transmission in the ICC by activating glycine-gated chloride channels. Our findings suggest that taurine acts as a ligand of glycine receptors in the ICC and can be involved in the information processing of the central auditory system similarly like the neuro transmitter glycine. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Sci & Technol China, Sch Life Sci, Audit Res Lab, Hefei 230027, Peoples R China.
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.
RP Xu, TL (reprint author), Univ Sci & Technol China, Sch Life Sci, Audit Res Lab, Hefei 230027, Peoples R China.
EM tlxu@ion.ac.cn; linchen@ustc.edu.cn
RI WANG, WEI/A-2176-2013; WANG, WEI/F-4992-2013; WANG, WEI/G-7605-2014;
Chen, Lin/N-8327-2013
OI Chen, Lin/0000-0002-5847-2989
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NR 79
TC 11
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 95
EP 105
DI 10.1016/j.heares.2006.07.005
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800010
PM 16949227
ER
PT J
AU Soeta, Y
Nakagawa, S
AF Soeta, Yoshiharu
Nakagawa, Seiji
TI Auditory evoked magnetic fields in relation to interaural time delay and
interaural correlation
SO HEARING RESEARCH
LA English
DT Article
DE auditory evoked field; Nlm; interaural time delay; interaural
correlation
ID SOUND IN-SPACE; CROSS-CORRELATION; INFERIOR COLLICULUS; ASYMMETRIC
PERFORMANCES; CORTICAL REPRESENTATION; LEVEL DIFFERENCES; CORRELATION
MODEL; HUMAN BRAIN; LOCALIZATION; LATERALIZATION
AB The detection of interaural time differences (ITD) for sound localization depends on the similarity between the left and right ear signals, namely interaural correlation (IAC). Human localization performance deteriorates with decreasing IACs. In order to examine activity related to localization performance in the human cortex, auditory evoked magnetic fields to the ITD of bandpass noises with different IACs were analyzed. When the JAC was 0.95, the N1m, amplitudes, i.e., the estimated equivalent current dipole moments, increased with increasing ITD. However the effect of ITD on the N1m amplitudes was not significant when the IAC was 0.5. When the ITD was 0.7 ins, the N1m amplitudes decreased with decreasing IACs. There were no systematic changes in the source location of N1m in the auditory cortex related to changes in ITD or IAC. The results suggest that localization performance is reflected in N1m amplitudes. (c) 2006 Elsevier B.V. All rights reserved.
C1 Natl Inst AIST, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
RP Soeta, Y (reprint author), Natl Inst AIST, Inst Human Sci & Biomed Engn, 1-8-31 Midorigaoka, Ikeda, Osaka 5638577, Japan.
EM y.soeta@aist.go.jp
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NR 51
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 106
EP 115
DI 10.1016/j.heares.2006.07.006
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800011
PM 16934951
ER
PT J
AU Li, HZ
Sabes, JH
Sinex, DG
AF Li, Hongzhe
Sabes, Jennifer H.
Sinex, Donal G.
TI Responses of inferior colliculus neurons to SAM tones located in
inhibitory response areas
SO HEARING RESEARCH
LA English
DT Article
DE amplitude modulation; inhibition; inferior colliculus; physiology;
chinchilla
ID SUPERIOR OLIVARY COMPLEX; COMBINATION-SENSITIVE NEURONS;
AMPLITUDE-MODULATED SIGNALS; GERBIL COCHLEAR NUCLEUS; SINGLE UNIT
RESPONSES; BIG BROWN BAT; LATERAL LEMNISCUS; GLYCINERGIC INHIBITION;
FREQUENCY MODULATIONS; AUDITORY RESPONSES
AB In order to examine the effect of inhibition on processing auditory temporal information, responses of single neurons in the inferior colliculus of the chinchilla to sinusoidally amplitude-modulated (SAM) tones alone and the presence of a steady-state tone were obtained. The carrier frequency of the SAM tone was either the characteristic frequency (CF) or a frequency in the inhibitory response area of a studied neuron. When the carrier frequency was set to the neuron's CF, neurons responded in synchrony to the SAM-tone envelope, as expected. When the carrier frequency was set to a frequency at which pure tones produced inhibition, SAM tones elicited little or no response, also as expected. However, when the same SAM tone was paired with a pure tone whose frequency was set to the neuron's CF, responses synchronized to the SAM tone envelope were obtained. These modulated responses were typically one-half cycle out-of-phase with the response to the SAM tone at CF, suggesting that they arose from cyclic inhibition and release from inhibition by the SAM tone. The results demonstrate that the representation of temporal information by inferior colliculus neurons is influenced by temporally-patterned inhibition arising from locations remote from CF. (c) 2006 Elsevier B.V. All rights reserved.
C1 Arizona State Univ, Dept Speech & Hearing Sci, Tempe, AZ 85287 USA.
Utah State Univ, Dept Psychol, Logan, UT 84322 USA.
RP Sinex, DG (reprint author), Utah State Univ, Dept Psychol, Logan, UT 84322 USA.
EM hongzhe@u.washington.edu; Jennifer.Henderson-Sabes@ucsfmedctr.org;
don.sinex@usu.edu
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NR 51
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2006
VL 220
IS 1-2
BP 116
EP 125
DI 10.1016/j.heares.2006.07.012
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 094JX
UT WOS:000241236800012
PM 16945495
ER
PT J
AU Lychakov, DV
Rebane, YT
Lombarte, A
Fuiman, LA
Takabayashi, A
AF Lychakov, D. V.
Rebane, Y. T.
Lombarte, A.
Fuiman, L. A.
Takabayashi, A.
TI Fish otolith asymmetry: Morphometry and modeling
SO HEARING RESEARCH
LA English
DT Article
DE fish; sacculus; utriculus; Otolith asymmetry; mathematical modeling
ID WEIGHTLESSNESS; SHAPE
AB Mathematical modeling suggests that relatively large values of otolith mass asymmetry in fishes can alter acoustic functionality and may be responsible for abnormal fish behavior when subjected to weightlessness during parabolic or space flight [D.V. Lychakov, Y.T. Rebane, Otolith mass asymmetry in 18 species of fish and pigeon, J. Grav. Physiol. 11 (3) (2004) 17-34; D.V. Lychakov, Y.T. Rebane, Fish otolith mass asymmetry: morphometry and influence on acoustic functionality, Hear. Res. 201 (2005) 55-69]. The results of morphometric studies of otolith mass asymmetry suppose that the absolute value and the sign of the otolith mass asymmetry can change many times during the growth of individual fish within the range +/- 20% [D.V. Lychakov, Y.T. Rebane, Otolith mass asymmetry in 18 species of fish and pigeon, J. Grav. Physiol. 11 (3) (2004) 17-34; D.V. Lychakov, Y.T. Rebane, Fish otolith mass asymmetry: morphometry and influence on acoustic functionality, Hear. Res. 201 (2005) 55-69]. This implies that the adverse effects of otolith asymmetry on acoustic and vestibular functionality could change during the lifetime of an individual fish. The aims of the present article were to examine the nature of otolith mass asymmetry fluctuation and to quantify otolith mass asymmetry in a large number of teleost fishes to verify our previous measurements.
A dimensionless measure of otolith mass asymmetry, chi, was calculated as the difference between the masses of the right and left paired otoliths divided by average otolith mass. Saccular otolith mass asymmetry was studied in 59 Mediterranean teleost species (395 otolith pairs), 14 Black Sea teleost species (42 otolith pairs), red drum (196 otolith pairs) and guppy (30 otolith pairs). Utricular otolith mass asymmetry was studied in carp (103 otolith pairs) and goldfish (45 otolith pairs). In accordance with our previous results the value of chi did not depend on fish size (length or mass), systematic or ecological position of the fish, or otolith growth rate. In the great majority of the fishes studied, the saccular otolith chi was small vertical bar chi vertical bar < 0.05 (or < 5%). Mathematical modeling indicates that values of chi vary among individual fish, but that the value is probably stable during a fish's lifetime. (c) 2006 Published by Elsevier B.V.
C1 Russian Acad Sci, IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg 194223, Russia.
Russian Acad Sci, AF Ioffe Phys Tech Inst, St Petersburg 194021, Russia.
CSIC, CMIMA, Inst Ciencies Mar, Dept Recursos Marins Renovables, E-08003 Barcelona, Spain.
Univ Texas, Inst Marine Sci, Dept Marine Sci, Port Aransas, TX 78373 USA.
Fujita Hlth Univ, Sch Hlth Sci, Toyoake, Aichi 4701192, Japan.
RP Lychakov, DV (reprint author), Russian Acad Sci, IM Sechenov Evolutionary Physiol & Biochem Inst, Thorez Pr 44, St Petersburg 194223, Russia.
EM Lychakov@iephb.ru
RI Lombarte, Antoni/D-3142-2013
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NR 19
TC 9
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 1
EP 11
DI 10.1016/j.heares.2006.03.019
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300001
PM 16859847
ER
PT J
AU MacArthur, CJ
Hefeneider, SH
Kempton, JB
Parrish, SK
McCoy, SL
Trune, DR
AF MacArthur, Carol J.
Hefeneider, Steven H.
Kempton, J. Beth
Parrish, Sarah K.
McCoy, Sharon L.
Trune, Dennis R.
TI Evaluation of the mouse model for acute otitis media
SO HEARING RESEARCH
LA English
DT Article
DE otitis media; mouse; inflammation; Streptococcus pneumoniae; auditory
brainstem response; middle ear
ID NONTYPABLE HAEMOPHILUS-INFLUENZAE; ROUND WINDOW MEMBRANE; SENSORINEURAL
HEARING-LOSS; MIDDLE-EAR; STREPTOCOCCUS-PNEUMONIAE; CHINCHILLA MODEL;
RAT MODEL; NASOPHARYNGEAL COLONIZATION; CYTOKINE GENES; MURINE MODEL
AB Various animal models have been employed for otitis media research. The mouse has been studied less, in spite of its many advantages. To better understand the suitability of the mouse for studies of otitis media, an evaluation was made of its middle ear inflammatory processes following inoculation with heat-killed Streptococcus pneumoniae (strain 6A), one of the three most common bacteria to cause otitis media in the human. A total of 94 BALB/c mice were injected transtympanically with three concentrations of heat-killed bacteria (10(4), 10(6), and 10(9) organisms per ml) and inflammation evaluated with both histologic examination and auditory brainstem response audiometry. Dose-related measures of the time course of inflammation showed it was maximal at 3 days. PBS-injected control mice also demonstrated some degree of middle ear inflammation. Therefore, inflammation measures from PBS injected mice were used as the threshold above which histologic inflammatory changes would be considered a response to bacteria. These quantitative comparisons of bacterial and PBS inoculations revealed the most significant middle ear measures of inflammation were amount of fluid in the middle ear, tympanic membrane thickness, and number of inflammatory cells. The induction of middle ear inflammation in the mouse demonstrated the applicability of this model for investigations of otitis media. (c) 2006 Elsevier B.V. All rights reserved.
C1 Oregon Hlth Sci Univ, Dept Otolaryngol, Portland, OR 97239 USA.
Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
Oregon Hlth Sci Univ, Dept Med, Div Rheumatol, Portland, OR 97239 USA.
Vet Affairs Med Ctr, Dept Immunol, Portland, OR 97239 USA.
Targeted Gene Delivery Inc, Portland, OR 97201 USA.
RP MacArthur, CJ (reprint author), Oregon Hlth Sci Univ, Dept Otolaryngol, 3181 SW Sam Jackson Pk Rd,PV-01, Portland, OR 97239 USA.
EM macarthc@ohsu.edu
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NR 46
TC 24
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 12
EP 23
DI 10.1016/j.heares.2006.05.012
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300002
PM 16887307
ER
PT J
AU Lineton, B
Thornton, ARD
Baker, VJ
AF Lineton, B.
Thornton, A. R. D.
Baker, V. J.
TI An investigation into the relationship between input-output
nonlinearities and rate-induced nonlinearities of click-evoked
otoacoustic emissions recorded using maximum length sequences
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emissions; click evoked; maximum length sequences;
rate-suppression
ID STIMULATED ACOUSTIC EMISSIONS; BRAIN-STEM RESPONSES; IPSILATERAL
SUPPRESSION; TEMPORAL INTERACTIONS; QUALITY ESTIMATION; LEVEL; EARS
AB The maximum length sequence (MLS) technique allows otoacoustic emissions (OAEs) to be recorded using clicks presented at very high presentation rates. It has previously been found that increasing the click presentation rate leads to increasing suppression (termed "rate-suppression") of the MLS evoked OAE (Hine, J.E., Thornton, A.R.D., 1997. Transient evoked otoacoustic emissions recorded using maximum length sequences as a function of stimulus rate and level. Ear Hear. 18, 121-128). It has been suggested that the source of rate-suppression arises from the same nonlinear processes that give rise to the well-known nonlinear growth of OAEs. Based on this assumption, a simple model of rate-suppression (Kapadia, S., Lutman, M.E., 2001. Static input-output nonlinearity as the source of nonlinear effects in maximum length sequence click-evoked OAEs. Br. J. Audiol. 35, 103-112) predicts that both input-output (I/O) nonlinearity and rate-suppression can be unified by characterising the stimulus in terms of its acoustic power which, at high rates, is proportional to the click presentation rate. The objective of this study was to test this simple model by recording MLS OAEs from a group of normally hearing adults over a range of stimulus rates from 40 to 5000 clicks/s, and of stimulus levels from 45 to 70 dB peSPL. The results are broadly in agreement with the predictions from the model, though there appears to be some tendency for the model to slightly overestimate the degree of rate-suppression for a given degree of I/O nonlinearity. It is also suggested that the model may break down more significantly in the presence of spontaneous OAEs. (c) 2006 Elsevier B.V. All rights reserved.
C1 Royal S Hants Hosp, MRC, Inst Hearing Res, Southampton SO14 0YG, Hants, England.
Univ Southampton, Sch Med, Div Clin Neurosci, Southampton SO16 7PX, Hants, England.
RP Lineton, B (reprint author), Univ Southampton, Inst Sound & Vibrat Res, Southampton SO17 1BJ, Hants, England.
EM bl@isvr.soton.ac.uk
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NR 40
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 24
EP 35
DI 10.1016/j.heares.2006.05.005
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300003
PM 16839721
ER
PT J
AU Micheyl, C
Delhommeau, K
Perrot, X
Oxenham, AJ
AF Micheyl, Christophe
Delhommeau, Karine
Perrot, Xavier
Oxenham, Andrew J.
TI Influence of musical and psychoacoustical training on pitch
discrimination
SO HEARING RESEARCH
LA English
DT Article
DE musicians; pitch; frequency discrimination; auditory training;
perceptual learning
ID AUDITORY FREQUENCY DISCRIMINATION; EAR DIFFERENCES; NON-MUSICIANS;
DOMINANCE; NONMUSICIANS; SPECIFICITY; PERCEPTION; TASK
AB This study compared the influence of musical and psych oacoustical training on auditory pitch discrimination abilities. In a first experiment, pitch discrimination thresholds for pure and complex tones were measured in 30 classical musicians and 30 non-musicians, none of whom had prior psychoacoustical training. The non-musicians' mean thresholds were more than six times larger than those of the classical musicians initially, and still about four times larger after 2 h of training using an adaptive two-interval forced-choice procedure; this difference is two to three times larger than suggested by previous studies. The musicians' thresholds were close to those measured in earlier psychoacoustical studies using highly trained listeners, and showed little improvement with training; this suggests that classical musical training can lead to optimal or nearly optimal pitch discrimination performance. A second experiment was performed to determine how much additional training was required for the non-musicians to obtain thresholds as low as those of the classical musicians from experiment 1. Eight new non-musicians with no prior training practiced the frequency discrimination task for a total of 14 h. It took between 4 and 8 h of training for their thresholds to become as small as those measured in the classical musicians from experiment 1. These findings supplement and qualify earlier data in the literature regarding the respective influence of musical and psychoacoustical training on pitch discrimination performance. (c) 2006 Elsevier B.V. All rights reserved.
C1 MIT, Elect Res Lab, Cambridge, MA 02139 USA.
CNRS, UMR 7593, Paris, France.
Montreal Neurol Inst, Neuropsychol Dept, Montreal, PQ, Canada.
Univ Lyon 1, CNRS, UMR 5020, F-69365 Lyon, France.
Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA.
RP Micheyl, C (reprint author), MIT, Elect Res Lab, 50 Vassar St,Bldg 36-758, Cambridge, MA 02139 USA.
EM cmicheyl@mit.edu
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NR 32
TC 100
Z9 102
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 36
EP 47
DI 10.1016/j.heares.2006.05.004
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300004
PM 16839723
ER
PT J
AU Dammeijer, PFM
van Dijk, P
Manni, JJ
van Mameren, H
AF Dammeijer, Patrick F. M.
van Dijk, Paul
Manni, Johannes J.
van Mameren, Henk
TI Stapedius muscle fiber characterization during postnatal development in
the rat
SO HEARING RESEARCH
LA English
DT Article
DE stapedius; myosin ATPase lability; myosin heavy chain; muscle
development; rat
ID MYOSIN HEAVY-CHAIN; SKELETAL-MUSCLE; SOUND-TRANSMISSION; MASSETER
MUSCLE; REFLEX; ISOFORMS; ATPASE; EXPRESSION; IDENTIFICATION;
TRANSITIONS
AB The stapedius muscle (SM) is reported to prevent cochlear damage by noise. Functional demands are then the ability of fast contraction with long endurance. At the end of the third postnatal week, the middle ear of the rat is completely pneumatized and according to electrophysiological data, the auditory function starts to match the adult.
We investigated the developmental changes in myosin composition of SM fibres using consecutive complete SM cross-sections (taken from rats on post natal day (PND) 7, 14, 16, 21, 28, 42 and 84) which were processed by enzymehistochemistry to determine acid/alkali lability of myofibrillar adenosine triphosphatase (mATPase) and by immunohistochemistry using myosin heavy chain (MHC) antibodies (mAb). Fibres were assigned to mATPase type I, IIA, IIB, IIX or `Miscellaneous' categories. Per mATPase category, the fibres were attributed to groups with specific MHC isoform compositions. Neonatal MHC expression could not be documented with the mAb used. However, embryonal (Emb) MHC was expressed at PND 7, very little at PND 14; at later PND fibres did not show Emb MHC. In general, the mATPase-based classification did not show large alterations after PND 21. Expression of MHC IIB, which was present in almost 50% of the fibres at PND 7 and 14, diminished to 3% at PND 84. A decrease in number of fibres expressing more than one MHC isoform was found. These results show that the SM is a precociously developing muscle compared to limb muscles and even to the diaphragm. Moreover, it is shown that the expression of the adult MHC isoform phenotype coincides with the onset of auditory function in the third postnatal week. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Maastricht, Dept Anat Embryol, NL-6200 MD Maastricht, Netherlands.
Univ Hosp Maastricht, Dept Otorhinolaryngol & Head & Neck Surg, NL-6202 AZ Maastricht, Netherlands.
RP Dammeijer, PFM (reprint author), Univ Maastricht, Dept Anat Embryol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM pdammeijer@home.nl; p.van-dijk@ae.unimaas.nl; jman@skno.azm.nl;
h.vanmameren@ae.unimaas.nl
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NR 39
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 48
EP 55
DI 10.1016/j.heares.2006.05.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300005
PM 16839722
ER
PT J
AU Thornton, ARD
Lineton, B
Baker, VJ
Slaven, A
AF Thornton, A. R. D.
Lineton, B.
Baker, V. J.
Slaven, A.
TI Nonlinear properties of otoacoustic emissions in normal and impaired
hearing
SO HEARING RESEARCH
LA English
DT Article
DE Nonlinear systems; maximum length sequences; cochlear amplifier;
otoacoustic emissions; Volterra kernels; cochlear pathology
ID MAXIMUM LENGTH SEQUENCES; SUPPRESSION; HUMANS; CLICKS; LEVEL
AB Click-evoked otoacoustic emissions (CEOAEs) exhibit nonlinearities in amplitude and time domains. The first objective of this study was to investigate whether there is any correlation between the temporal and amplitude nonlinearities of CEOAEs in normals. Additionally there is evidence that pathology affects the normal cochlear nonlinearity. The second objective was to investigate whether pathology affects the temporal nonlinear components.
Conventional and maximum length sequence (MLS) CEOAEs were recorded in normal subjects and in patients with mild hearing loss. The slope of the input-output (I/O) function of the conventional CEOAE measured the amplitude nonlinearity. Two measures of temporal nonlinearity were the magnitude of the suppression that occurs with increase in stimulus rate and the amplitudes of the second and third order temporal interaction components (Volterra slices).
The amplitude nonlinearity is well correlated with both the magnitude of the rate suppression and the amplitudes of the Volterra slices. The `linear' CEOAE amplitude showed no differences between the normal and patient groups but the differences in the Volterra slices were substantial. This suggests that the first sign of damage to the cochlea is that the system becomes more linear. Hence the Volterra slices may provide a sensitive measure of cochlear damage. (c) 2006 Elsevier B.V. All rights reserved.
C1 Royal S Hants Hosp, MRC, Inst Hearing Res, Southampton Sect, Southampton SO14 0YG, Hants, England.
Univ Southampton, Sch Med, Dept Clin Neurosci, Southampton SO16 7PX, Hants, England.
RP Thornton, ARD (reprint author), Royal S Hants Hosp, MRC, Inst Hearing Res, Southampton Sect, Mailpoint OAU, Southampton SO14 0YG, Hants, England.
EM ardt@soton.ac.uk
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NR 30
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 56
EP 65
DI 10.1016/j.heares.2006.05.010
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300006
PM 16839724
ER
PT J
AU Lee, JH
Heo, JH
Chang, SO
Kim, CS
Oh, SH
AF Lee, Jun Ho
Heo, Jeong-Hwa
Chang, Sun O.
Kim, Chong-Sun
Oh, Seung-Ha
TI Reactive blue 2, an antagonist of rat P2Y(4), increases K+ secretion in
rat cochlea strial marginal cells
SO HEARING RESEARCH
LA English
DT Article
DE voltage-sensitive vibrating probe; strial marginal cell; cochlea; rat;
P2Y(4); reactive blue
ID P2X(2) RECEPTOR SUBUNIT; ION-CHANNEL FUNCTION; I-SK CHANNEL; INNER-EAR;
APICAL MEMBRANE; AUDITORY NEUROTRANSMISSION; ISK/KVLQT1 CHANNELS; SOUND
TRANSDUCTION; GUINEA-PIG; VASCULARIS
AB Extracellular ATP decreases K+ secretion in strial marginal cells via apical P2Y(4) receptors. We investigated the effect of reactive blue 2 (RB-2), an antagonist of rat P2Y(4), on rat strial marginal cells using a voltage-sensitive vibrating probe. The application of RB-2 increased K+ secretion in a dose-dependent manner, and this increase was characterized as a peak followed by a partial relaxation to a steady-state. Moreover, this response was similar to that caused by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Suramin had no similar effect, except at high concentration. Thus, we tested the effects of these chemicals on P2Y(4) receptors in strial marginal cells. Both RB-2 and DIDS had antagonistic activities at P2Y(4), and the antagonist potency at P2Y(4) paralleled the potency of K+ secretion. Interestingly, 2'- and 3'-O-(4-benzoyl-benzoyl)adenosine 5'-triphosphate (BzATP) exhibited an agonistic effect at P2Y(4) receptor, which was blocked by RB-2, but not by pyridoxalphosphate-6-azophenyl-2', 4'-disulfonic acid (PPADS). Based on these results, we speculate that direct and/or indirect inhibitory mechanisms between P2Y(4) and KENQ1/KCNEI K+ channels exist in strial marginal cell. (c) 2006 Elsevier B.V. All rights reserved.
C1 Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Otolaryngol Head & Neck Surg, Seoul 110744, South Korea.
Seoul Natl Univ, Bundang Hosp, Dept Otolaryngol Head & Neck Surg, Coll Med, Songnam 463707, Kunggi Do, South Korea.
RP Oh, SH (reprint author), Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Otolaryngol Head & Neck Surg, 28 Yeongon Dong, Seoul 110744, South Korea.
EM junlee@snu.ac.kr; amaranthh@paran.com; suno@snu.ac.kr;
chongkim@plaza.snu.ac.kr; shaoh@snu.ac.kr
RI Oh, Seung Ha/J-5540-2012
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NR 33
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 66
EP 73
DI 10.1016/j.heares.2006.05.011
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300007
PM 16839719
ER
PT J
AU Jin, Z
Mannstrom, P
Skjonsberg, A
Jarlebark, L
Ulfendahl, M
AF Jin, Zhe
Mannstrom, Paula
Skjonsberg, Asa
Jarlebark, Leif
Ulfendahl, Mats
TI Auditory function and cochlear morphology in the German waltzing guinea
pig
SO HEARING RESEARCH
LA English
DT Article
DE deafness; inner ear; melanocytes; phenotype; recessive genes; stria
vascularis
ID MYOSIN-VIIA GENE; STRIA VASCULARIS; INNER-EAR; DEAFNESS; STRAIN; MOUSE;
HEREDITY; MUTATION; HEARING; TRAUMA
AB The German waltzing guinea pig is a new strain of animals with a recessively inherited inner ear defect resulting in deafness and severe vestibular dysfunction. Measurements of auditory brainstem responses (ABRs) demonstrated that the homozygotes (gw/gw) are deaf while the heterozygotes (gw/+) have normal hearing. In the gw/gw cochlea, a collapse of Reissner's membrane leads to the absence of scala media. Melanin pigment accumulation was clearly observed in the gw/gw stria vascularis, and both the height and width of stria vascularis were significantly reduced. Ultrastructural observations further detailed the disorganization of stria vascularis in the gw/gw animals: marginal cells lacked basolateral infoldings; intermediate cells (melanocytes) were scarce and degenerated; and basal cells were difficult to identify. The level of degeneration of the organ of Corti varied between individual gw/gw animals. The density of spiral ganglion neurons was significantly decreased in old (1-2 years of age) gw/gw animals. In contrast, no pathological changes were observed in the cochleae of gw/+ animals. Our data suggest that the degeneration originates in the stria vascularis (most likely in the melanocytes), and that this is the primary cause for inner ear defects in the German waltzing guinea pig. Here, we describe the auditory function and cochlear morphology in this spontaneously mutated guinea pig strain. (c) 2006 Elsevier B.V. All rights reserved.
C1 Karolinska Inst, Ctr Hearing & Commun Res, Dept Clin Neurosci, SE-17176 Stockholm, Sweden.
Stockholm Univ, Karolinska Hosp, Dept Otolaryngol, SE-17176 Stockholm, Sweden.
RP Ulfendahl, M (reprint author), Stockholm Univ, Karolinska Hosp, Dept Clin Neurosci, Ctr Hearing & Commun Res,Karolinska Inst, Bldg M1-02, SE-17176 Stockholm, Sweden.
EM zhe.jin@ki.se; paula.mannstrom@ki.se; asa.skjonsberg@ki.se;
leif.jarlebark@ki.se; mats.ulfendahl@ki.se
RI Jin, Zhe/C-5150-2008
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NR 33
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 74
EP 84
DI 10.1016/j.heares.2006.06.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300008
PM 16870368
ER
PT J
AU Dajani, HR
Picton, TW
AF Dajani, Hilmi R.
Picton, Terence W.
TI Human auditory steady-state responses to changes in interaural
correlation
SO HEARING RESEARCH
LA English
DT Article
DE steady-state responses; binaural hearing; interaural correlation; time
constants; binaural sluggishness; auditory modeling
ID BINAURAL INTERACTION COMPONENT; HUMAN EVOKED-POTENTIALS; AURAL
CORRELATION; SOUND-SOURCE; BRAIN-STEM; CORRELATION DISCRIMINATION;
INFERIOR COLLICULUS; LEVEL DIFFERENCE; TIME DIFFERENCE; PHASE DISPARITY
AB Steady-state responses were evoked by noise stimuli that alternated between two levels of interaural correlation rho at a frequency f(m). With rho alternating between +1 and 0, responses at fm dropped steeply above 4 Hz, but persisted up to 64 Hz. Two time constants of 47 and 4.4 ms with delays of 198 and 36 ms, respectively, were obtained by fitting responses to a transfer function based on symmetric exponential windows. The longer time constant, possibly reflecting cortical integration, is consistent with perceptual binaural "sluggishness". The shorter time constant may reflect running cross-correlation in the high brainstem or primary auditory cortex. Responses at 2f(m) peaked with an amplitude of 848 +/- 479 nV (f(m) = 4 Hz). Investigation of this robust response revealed that: (1) changes in rho and later-alization evoked similar responses, suggesting a common neural origin, (2) response was most dependent on stimulus frequencies below 1000 Hz, but frequencies up to 4000 Hz also contributed, and (3) when rho alternated between [0.2-1] and 0, response amplitude varied linearly with rho, and the physiological response threshold was close to the average behavioral threshold (rho = 0.31). This steady-state response may prove useful in the objective investigation of binaural hearing. (c) 2006 Elsevier B.V. All rights reserved.
C1 Rotman Res Inst Baycrest, Toronto, ON M6A 2E1, Canada.
Univ Toronto, Toronto, ON M6A 2E1, Canada.
RP Dajani, HR (reprint author), Rotman Res Inst Baycrest, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada.
EM h.dajani@utoronto.ca; tpicton@rotman-baycrest.on.ca
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NR 66
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 85
EP 100
DI 10.1016/j.heares.2006.06.003
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300009
PM 16870369
ER
PT J
AU Grant, L
Slapnick, S
Kennedy, H
Hackney, C
AF Grant, Lisa
Slapnick, Susan
Kennedy, Helen
Hackney, Carole
TI Ryanodine receptor localisation in the mammalian cochlea: An
ultrastructural study
SO HEARING RESEARCH
LA English
DT Article
DE hair cells; calcium-induced calcium release; subsurface cisternae;
synatoplasmic cistern; cochlear efferents; immunogold; hearing
ID OUTER HAIR-CELLS; GUINEA-PIG COCHLEA; INTRACELLULAR CALCIUM-RELEASE;
SUBSURFACE CISTERNAE; TRANSMITTER RELEASE; CA2+ STORE; CHANNELS; INNER;
EXOCYTOSIS; PLASTICITY
AB Calcium-induced calcium release (CICR) in the mammalian cochlea has been suggested to enhance neurotransmitter release from inner hair cells and facilitate the efferent response in outer hair cells. Light microscopic evidence exists for the presence of ryanodine receptors in the organ of Corti but there is so far no information about their ultrastructural localisation. We have therefore used post-embedding immunogold labeling with antibodies that predominantly recognise ryanodine receptor isoforms 1 (RyR1) and 2 (RyR2) to investigate their distribution in rat cochleae. In inner hair cells, the highest levels of labeling were observed over an area of rough endoplasmic reticulum that lies in the cytoplasmic region beneath the nucleus; in outer hair cells, the cytoplasmic region above the nucleus displayed most labeling. Labeling was also associated with the subsurface cisternae adjacent to the lateral membranes of both types of hair cell, with the efferent terminals on the outer hair cells and was observed in adjacent supporting cells. Labeling in outer hair cells was significantly higher than that in inner hair cells or in the supporting cells. Our results support the presence of RyR1 in the cochlea but do not rule out the presence of other isoforms. CICR may be involved in the control of calcium levels in the base of the inner hair cells and supporting cells, and in the cholinergic efferent response and motile behaviour of the outer hair cells. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Keele, Sch Life Sci, Inst Sci & Technol Med, Keele ST5 5BG, Staffs, England.
Univ Wisconsin, Dept Anat, Madison, WI 53706 USA.
Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA.
Univ Bristol, Dept Physiol, Bristol BS8 1TD, Avon, England.
RP Hackney, C (reprint author), Univ Keele, Sch Life Sci, Inst Sci & Technol Med, Keele ST5 5BG, Staffs, England.
EM lisa.grant@bristol.ac.uk; Slapnick@wise.edu;
helen.kennedy@bristol.ac.uk; coa38@keele.ac.uk
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NR 46
TC 12
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 101
EP 109
DI 10.1016/j.heares.2006.06.002
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300010
PM 16889917
ER
PT J
AU Zheng, QY
Yu, H
Washington, JL
Kisley, LB
Kikkawa, YS
Pawlowski, KS
Wright, CG
Alagramam, KN
AF Zheng, Q. Y.
Yu, H.
Washington, J. L.
Kisley, L. B.
Kikkawa, Y. S.
Pawlowski, K. S.
Wright, C. G.
Alagramam, K. N.
TI A new spontaneous mutation in the mouse protocadherin 15 gene
SO HEARING RESEARCH
LA English
DT Article
DE deafness; cochlear hair cells; Pcdh15; mouse
ID USHER-SYNDROME; HEARING-LOSS; PCDH15; MICE; ADHESION; ALLELES; STRAINS;
MUTANT; 1F
AB We have characterized a new allele of the protocadherin 15 gene (designated Pcdh15(av-6J)) that arose as a spontaneous, recessive mutation in the C57BL/6J inbred strain at Jackson Laboratory. Analysis revealed an inframe deletion in Pcdh15, which is predicted to result in partial deletion of cadherin domain (domain 9) in Pcdh15. Morphologic study revealed normal to moderately defective cochlear hair cell stereocilia in Pcdh15(av-6J) mutants at postnatal day 2 (P2). Stereocilia abnormalities were consistently present at P5 and P10. Degenerative changes including loss of inner and outer hair cells were seen at P20, with severe sensory cell loss in all cochlear turns occurring by P40. The hair cell phenotype observed in the 6J allele between PO and P20 is the least severe phenotype yet observed in Pcdh15 alleles. However, young Pcdh15(av-6J) mice are unresponsive to auditory stimulation and show circling behavior indicative of vestibular dysfunction. Since these animals show severe functional deficits but have relatively mild stereocilia defects at a young age they may provide an appropriate model to test for a direct role of Pcdh15 in mechanotransduction. (c) 2006 Elsevier B.V. All rights reserved.
C1 Case Western Reserve Univ, Cleveland, OH 44106 USA.
Jackson Lab, Bar Harbor, ME 04609 USA.
Univ Texas, SW Med Ctr, Dallas, TX 75390 USA.
RP Alagramam, KN (reprint author), Case Western Reserve Univ, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM kna3@case.edu
RI Zheng, Qing/C-1731-2012
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NR 18
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 110
EP 120
DI 10.1016/j.heares.2006.06.010
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300011
PM 16887306
ER
PT J
AU de Boer, J
Thornton, ARD
AF de Boer, Jessica
Thornton, A. Roger D.
TI Volterra Slice otoacoustic emissions recorded using maximum length
sequences from patients with sensorineural hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE evoked otoacoustic emissions; hearing loss; maximum length sequence;
Volterra series; non-linearity
ID AMINOGLYCOSIDE-INDUCED OTOTOXICITY; ACOUSTIC EMISSIONS; IMPAIRED
SUBJECTS; NORMALLY HEARING; CLICK; IDENTIFICATION; EARS
AB When normally hearing ears are stimulated with maximum length sequences (MLS) of clicks, a family of non-linear temporal interaction components of otoacoustic emissions (OAEs) can be derived, which have been named Volterra Slice OAEs (VS OAEs). This study investigates the sensitivity of VS OAEs to sensorineural hearing impairment in adults, compared to that of the widely used derived non-linear click evoked OAE (DNL CEOAE). VS OAEs and DNL CEOAEs were obtained from 24 normally hearing and 24 hearing impaired ears using a custom-built MLS system and a Otodynamics `IL088' OAE Analyzer, respectively. The results show that, based on waveform reproducibility, VS OAEs are as successful as DNL CEOAEs at separating normal from impaired ears at the audiometric frequencies of 1 and 2 kHz, where a strong correlation is found between the amplitudes of the two OAE types. At 4 kHz however, VS OAEs are a significantly better indicator of hearing loss than DNL CEOAEs. This difference at 4 kHz appears to be due to the lack of stimulus artefact contamination of VS OAEs in the early, high frequency portion of the response. The findings suggest that VS OAEs may provide a better diagnostic and monitoring tool for hearing loss at high frequencies than the conventional DNL CEOAE. (c) 2006 Published by Elsevier B.V.
C1 Royal S Hants Hosp, Southamapton Outstn, MRC, Inst Hearing Res, Southampton SO14 0YG, Hants, England.
RP de Boer, J (reprint author), Royal S Hants Hosp, Southamapton Outstn, MRC, Inst Hearing Res, Brintons Terrace Mailpoint OAU, Southampton SO14 0YG, Hants, England.
EM jdbl@soton.ac.uk
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NR 32
TC 2
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2006
VL 219
IS 1-2
BP 121
EP 136
DI 10.1016/j.heares.2006.06.009
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 085YW
UT WOS:000240641300012
PM 16887305
ER
PT J
AU Brunso-Bechtold, JK
Evans, SD
Henkel, CK
AF Brunso-Bechtold, Judy K.
Evans, Stephanie D.
Henkel, Craig K.
TI Synaptogenesis in the inferior colliculus of the pre-hearing postnatal
ferret
SO HEARING RESEARCH
LA English
DT Article
DE postnatal development; electron microscopy; auditory midbrain
ID RAT; NUCLEUS; FEATURES
AB Although intrinsic organization in the inferior colliculus (IC) has been surveyed in a variety of species, current knowledge of synaptogenesis within the mammalian inferior colliculus is limited. The present study surveyed the ultrastructure of the central nucleus of the inferior colliculus in postnatal day (P) P4, P7, P14, and P28 ferrets, prior to the onset of hearing at the end of the first postnatal month with the goal of beginning to characterize the time course of synapse formation in relation to the development of afferent projection patterns within the IC. Results suggest that initial synaptogenesis has occurred in the IC by P4 and continues during the period when maturation of the distribution of axons from brainstem auditory nuclei is taking place. (c) 2006 Elsevier B.V. All rights reserved.
C1 Wake Forest Univ, Dept Neurobiol & Anat, Winston Salem, NC 27157 USA.
Wake Forest Univ, Neurosci Program, Winston Salem, NC 27157 USA.
RP Brunso-Bechtold, JK (reprint author), Wake Forest Univ, Dept Neurobiol & Anat, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM jbrunso@wfubmc.edu
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NR 11
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 1
EP 4
DI 10.1016/j.heares.2006.03.017
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000001
PM 16766149
ER
PT J
AU Riedel, H
Kollmeier, B
AF Riedel, Helmut
Kollmeier, Birger
TI Interaural delay-dependent changes in the binaural difference potential
of the human auditory brain stem response
SO HEARING RESEARCH
LA English
DT Article
DE binaural difference potential; interaural time difference; auditory
brain stem response; delay line; Jeffress model; chirp; lateralization;
azimuth
ID SUPERIOR OLIVARY COMPLEX; UNIT EXCITATORY RESPONSES; HUMAN
EVOKED-POTENTIALS; HIGH-FREQUENCY NEURONS; TIME DIFFERENCES; INTERACTION
COMPONENT; INFERIOR COLLICULUS; SOUND LOCALIZATION; COINCIDENCE
DETECTION; TEMPORAL DISPARITIES
AB Binaural difference potentials (BDs) are thought to be generated by neural units in the brain stem responding specifically to binaural stimulation. They are computed by subtracting the sum of monaural responses from the binaural response, BD = B - (L + R). BDs in dependency on the interaural time difference (ITD) have been measured and compared to the Jeffress model in a number of studies with conflicting results. The classical Jeffress model assuming binaural coincidence detector cells innervated by bilateral excitatory cells via two delay lines predicts a BD latency increase of ITD/2. A modification of the model using only a single delay line as found in birds yields a BD latency increase of ITD. The objective of this study is to measure BDs with a high signal-to-noise ratio for a large range of ITDs and to compare the data with the predictions of some models in the literature including that of Jeffress. Chirp evoked BDs were recorded for 17 ITDs in the range from 0 to 2 ms at a level of 40 dB nHL for four channels (A1, A2, PO9, PO10) from 11 normal hearing subjects. For each binaural condition 10,000 epochs were collected while 40,000 epochs were recorded for each of the two monaural conditions. Significant BD components are observed for ITDs up to 2 ms. The peak-to-peak amplitude of the first components of the BD, DP1-DN1, is monotonically decreasing with ITD. This is in contrast with click studies which reported a constant BD-amplitude for ITDs up to I ms. The latency of the BD-component DN1 is monotonically, but nonlinearly increasing with ITD. In the current study, DN1 latency is found to increase faster than ITD/2 but slower than ITD incompatible with either variant of the Jeffress model. To describe BD waveforms, the computational model proposed by Ungan et al. [Hearing Research 106, 66-82, 1997] using ipsilateral excitatory and contralateral inhibitory inputs to the binaural cells was implemented with only four parameters and successfully fitted to the BD data. Despite its simplicity the model predicts features which can be physiologically tested: the inhibitory input must arrive slightly before the excitatory input, and the duration of the inhibition must be considerably longer than the standard deviations of excitatory and inhibitory arrival times to the binaural cells. With these characteristics, the model can accurately describe BD amplitude and latency as a function of the ITD. (c) 2006 Elsevier B.V. All rights reserved.
C1 Carl von Ossietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
RP Riedel, H (reprint author), Carl von Ossietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
EM helmut.riedel@uni-oldenburg.de
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NR 95
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 5
EP 19
DI 10.1016/j.heares.2006.03.018
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000002
PM 16762518
ER
PT J
AU Abrashkin, KA
Izumikawa, M
Miyazawa, T
Wang, CH
Crumling, MA
Swiderski, DL
Beyer, LA
Gong, TWL
Raphael, Y
AF Abrashkin, Karen A.
Izumikawa, Masahiko
Miyazawa, Toru
Wang, Chih-Hung
Crumling, Mark A.
Swiderski, Donald L.
Beyer, Lisa A.
Gong, Tzy-Wen L.
Raphael, Yehoash
TI The fate of outer hair cells after acoustic or ototoxic insults
SO HEARING RESEARCH
LA English
DT Article
DE guinea pig; mouse; prestin; overstimulation; ototoxicity; outer hair
cell; supporting cell
ID AMINOGLYCOSIDE OTOTOXICITY; GENTAMICIN TREATMENT; APOPTOTIC CELLS; MOTOR
PROTEIN; RAT ORGAN; IN-VIVO; COCHLEA; CORTI; PRESTIN; TRAUMA
AB In epithelial sheets, clearance of dead cells may occur by one of several routes, including extrusion into the lumen, phagocytic clearance by invading lymphocytes, or phagocytosis by neighboring cells. The fate of dead cochlear outer hair cells is unclear. We investigated the fate of the "corpses" of dead outer hair cells in guinea pigs and mice following drug or noise exposure. We examined whole mounts and plastic sections of normal and lesioned organ of Corti for the presence of prestin, a protein unique to outer hair cells. Supporting cells, which are devoid of prestin in the normal ear, contained clumps of prestin in areas of hair cell loss. The data show that cochlear supporting cells surround the corpses and/or debris of degenerated outer hair cells, and suggest that outer hair cell remains are phagocytosed by supporting cells within the epithelium. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, Ann Arbor, MI 48109 USA.
RP Raphael, Y (reprint author), Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, Rm 9301 MSRB-3, Ann Arbor, MI 48109 USA.
EM Yoash@umich.edu
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NR 32
TC 37
Z9 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 20
EP 29
DI 10.1016/j.heares.2006.04.001
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000003
PM 16777363
ER
PT J
AU Throckmorton, CS
Kucukoglu, MS
Remus, JJ
Collins, LM
AF Throckmorton, Chandra S.
Kucukoglu, M. Selin
Remus, Jeremiah J.
Collins, Leslie M.
TI Acoustic model investigation of a multiple carrier frequency algorithm
for encoding fine frequency structure: Implications for cochlear
implants
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Conference on Implantable Auditory Prostheses
CY AUG, 2005
CL Asilomar, CA
DE frequency discrimination; frequency modulation; acoustic model; cochlear
implant
ID SPEECH-RECOGNITION; ELECTRODE DISCRIMINATION; ELECTRICAL-STIMULATION;
SIGNAL PROCESSORS; NORMAL-HEARING; NOISE; PERCEPTION; CHANNELS; PITCH;
PERFORMANCE
AB Current cochlear implants provide frequency resolution through the number of channels. Improving resolution by increasing channels is limited by factors such as the physiological feasibility of increasing the number of electrodes, the inability to increase the number of channels for those already implanted, and the increased possibility of channel interactions reducing channel efficacy. Recent studies have suggested an alternative method: providing a continuum of pitch percepts for each channel based on the frequency content of that channel. This study seeks to determine the frequency resolution necessary for the highest performance gain, which may give some indication of the feasibility for implementation in implants. A discrete set of carrier frequencies, instead of a continuum, are evaluated using an acoustic model to measure speech recognition. Performance increased as the number of available frequencies increased, and substantive improvement was seen with as few as two frequencies per channel. The effect of variable frequency discrimination was also assessed, and the results suggest that frequency modulation can still provide benefits with poor frequency discrimination on some channels. These results suggest that if two or more discriminable frequencies per channel can be generated for cochlear implant subjects then an improvement in speech recognition may be possible. (c) 2006 Elsevier B.V. All rights reserved.
C1 Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA.
RP Collins, LM (reprint author), Duke Univ, Dept Elect & Comp Engn, 130 Hudson Hall,POB 90291, Durham, NC 27708 USA.
EM cst@ee.duke.edu; msk5@ee.duke.edu; jjr6@ee.duke.edu;
lcollins@ee.duke.edu
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NR 46
TC 13
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 30
EP 42
DI 10.1016/j.heares.2006.03.020
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000004
PM 16797896
ER
PT J
AU Zhou, JX
Balaban, C
Durrant, JD
AF Zhou, Jianxun
Balaban, Carey
Durrant, John D.
TI Effect of intracochlear perfusion of vanilloids on cochlear neural
activity in the guinea pig
SO HEARING RESEARCH
LA English
DT Article
DE capsaicin; cochlear neural activity; pain
ID PROTEIN-KINASE-C; SPIRAL GANGLION NEURONS; INNER-EAR; CAPSAICIN
RECEPTOR; KANAMYCIN CHALLENGE; BACKGROUND ACTIVITY; MESSENGER-RNA;
ROUND-WINDOW; RAT; VR1
AB Recent findings show that the vanilloid receptor subtype 1 (TRPV1) is expressed by cochlear outer hair cells and spiral ganglion cells, and that its expression is up-regulated in ganglion cells after aminoglycoside treatment. This study tested the hypothesis that agents that act on TRPV1 receptors affect the spectrum of ensemble background activity (EBA). Consecutive intracochlear perfusions of the TRPV1 agonist, capsaicin (CAP 0.1, 1, and 10 parts per million), as well as its antagonist capsazepine (CZP), were used to test effects of TRPV1 activation on EBA recorded from the cochlear base. Perfusion with CAP alone produced a dose-dependent increase of the 900-Hz peak ratio (power normalized re the overall spectrum) of the EBA. The CAP effect was attenuated during concurrent perfusion with CZP. These findings are consistent with the hypothesis that TRPV1 activation increases background activity of spiral ganglion cells and support a role of TRPV1 in gating spontaneous and evoked auditory nerve excitability. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Pittsburgh, Dept Commun Sci & Disorders, Pittsburgh, PA 15260 USA.
Univ Pittsburgh, Dept Otolaryngol, Eye & Ear Inst 107, Pittsburgh, PA 15213 USA.
Univ Pittsburgh, Dept Neurobiol, Eye & Ear Inst 107, Pittsburgh, PA 15213 USA.
RP Durrant, JD (reprint author), Univ Pittsburgh, Dept Commun Sci & Disorders, Forbes Tower 4033, Pittsburgh, PA 15260 USA.
EM durrant@pitt.edu
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NR 39
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 43
EP 49
DI 10.1016/j.heares.2006.02.013
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000005
PM 16781098
ER
PT J
AU Seither-Preisler, A
Patterson, RD
Krumbholz, K
Seither, S
Lutkenhoner, B
AF Seither-Preisler, A.
Patterson, Roy D.
Krumbholz, K.
Seither, S.
Luetkenhoener, B.
TI From noise to pitch: Transient and sustained responses of the auditory
evoked field
SO HEARING RESEARCH
LA English
DT Article
DE pitch; spectral bandwidth; temporal coding; auditory cortex; RIS; MEG;
pitch onset response; sustained field
ID ITERATED RIPPLED NOISE; NEUROMAGNETIC EVIDENCE; MAGNETIC-FIELDS; HESCHLS
GYRUS; NEURAL TRANSDUCTION; SENSORY MEMORY; SOUND-LEVEL; HUMAN-BRAIN;
LOWER LIMIT; CORTEX
AB In recent magnetoencephalographic studies, we established a novel component of the auditory evoked field, which is elicited by a transition from noise to pitch in the absence of a change in energy. It is referred to as the 'pitch onset response'. To extend our understanding of pitch-related neural activity, we compared transient and sustained auditory evoked fields in response to a 2000-ms segment of noise and a subsequent 1000-ms segment of regular interval sound (RIS). RIS provokes the same long-term spectral representation in the auditory system as noise, but is distinguished by a definite pitch, the salience of which depends on the degree of temporal regularity. The stimuli were presented at three steps of increasing regularity and two spectral bandwidths. The auditory evoked fields were recorded from both cerebral hemispheres of twelve subjects with a 37-channel magnetoencephalographic system. Both the transient and the sustained components evoked by noise and RIS were sensitive to spectral bandwidth. Moreover, the pitch salience of the RIS systematically affected the pitch onset response, the sustained field, and the off-response. This indicates that the underlying neural generators reflect the emergence, persistence and offset of perceptual attributes derived from the temporal regularity of a sound. (c) 2006 Elsevier B.V. All rights reserved.
C1 Munster Univ Hosp, ENT Clin, Dept Expt Audiol, D-48149 Munster, Germany.
Univ Cambridge, Dept Physiol, Ctr Neural Basis Hearing, Cambridge CB2 3EG, England.
MRC, Inst Hearing Res, Nottingham NG7 2RD, England.
RP Seither-Preisler, A (reprint author), Graz Univ, Dept Psychol, Cognit Sci Sect, Univ Pl 2-3, A-8010 Graz, Austria.
EM annemarie.seither-preisler@uni-graz.at
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NR 57
TC 19
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 50
EP 63
DI 10.1016/j.heares.2006.04.005
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000006
PM 16814971
ER
PT J
AU Soeta, Y
Nakagawa, S
Matsuoka, K
AF Soeta, Yoshiharu
Nakagawa, Seiji
Matsuoka, Katsunori
TI The effect of center frequency and bandwidth on the auditory evoked
magnetic field
SO HEARING RESEARCH
LA English
DT Article
DE magnetoencephalography; auditory evoked response; Nlm; loudness; center
frequency; bandwidth
ID INTENSITY-DISCRIMINATION; TONOTOPIC ORGANIZATION; COMPLEX SOUNDS;
HUMAN-BRAIN; CEREBRAL-CORTEX; MIDDLE-EAR; REPRESENTATION; STIMULUS;
NOISE; TONES
AB Auditory evoked magnetic fields in relation to the center frequency of sound with a certain bandwidth were examined by magnetoencephalography (MEG). Octave band, 1/3 octave band, and 130 Hz bandwidth noises were used as the sound stimuli. All signals were presented at 60 dB SPL. The stimulus duration was 500 ms, with rise and fall ramps of 10 ms. Ten normal-hearing subjects took part in the study. Auditory evoked fields were recorded using a 122 channel whole-head magnetometer in a magnetically shielded room. The latencies, source strengths and coordinates of the N1m wave, which was found above the left and right temporal lobes around 100 ms after the stimulus onset, were analyzed. The results demonstrated that the middle frequency range had shorter N1m latencies and larger N1m amplitudes, and that the lower and higher frequency stimuli had relatively delayed N1m latencies and decreased N1m amplitudes. The N1m amplitudes correlated well to the loudness values in the frequency ranges between 250 and 2000 Hz. The source locations of N1m did not reveal any systematic changes related to the center frequency and bandwidth. (c) 2006 Elsevier B.V. All rights reserved.
C1 Natl Inst AIST, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
RP Soeta, Y (reprint author), Natl Inst AIST, Inst Human Sci & Biomed Engn, 1-8-31 Midorigaoka, Ikeda, Osaka 5638577, Japan.
EM y.soeta@aist.go.jp
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NR 48
TC 2
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 64
EP 71
DI 10.1016/j.heares.2006.04.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000007
PM 16797895
ER
PT J
AU Okoyama, S
Ohbayashi, M
Ito, M
Harada, S
AF Okoyama, Shigeo
Ohbayashi, Masao
Ito, Makoto
Harada, Shinichi
TI Neuronal organization of the rat inferior colliculus participating in
four major auditory pathways
SO HEARING RESEARCH
LA English
DT Article
DE neuronal classification; collateral projections; retrograde tracing;
ascending pathway; descending pathway; commissural pathway
ID FREQUENCY-RESPONSE AREAS; SUPERIOR OLIVARY COMPLEX; MEDIAL
GENICULATE-BODY; CENTRAL NUCLEUS; GUINEA-PIG; GABAERGIC NEURONS;
COCHLEAR NUCLEUS; BRAIN-SLICES; ALBINO-RAT; CELL-TYPES
AB The central nucleus of the inferior colliculus (CNIC) contains different types of neurons and is a source of ascending projection to the medial geniculate body (MGB), commissural projection to the contralateral IC, direct descending projection to the cochlea nucleus (CN) and indirect projection to the CN via the superior olivary complex (SOC). Using a retrograde tracing technique, we examined what kind of neurons and what percentage of neurons of each type recognized in the CNIC participated in the above-mentioned four projection pathways. We also examined whether the individual CNIC neurons send the collateral to the NIGB, the contralateral IC, the CN and the soc.
In the present study, we demonstrated that the neurons participating in the four projections could be morphologically classified into two types of neurons with soma size variation. The percentages of neurons of each type differed among the four projection pathways. Using a double-labeling technique, we found very few double-labeled neurons, indicating the collateral projections to the ipsilateral MGB and the contralateral IC. There were no double-labeled neurons in the collateral projections between the other combinations of targets. Therefore, we conclude that the ascending projection, the commissural projection and the descending projection to these targets arise from separate populations of neurons. (c) 2006 Elsevier B.V. All rights reserved.
C1 Kanazawa Univ, Grad Sch Med Sci, Ctr Biomed Res & Educ, Lab Neuroanat, Kanazawa, Ishikawa 9208640, Japan.
Kanazawa Univ, Grad Sch Med Sci, Div Neurosci, Kanazawa, Ishikawa 9208640, Japan.
RP Okoyama, S (reprint author), Kanazawa Univ, Grad Sch Med Sci, Ctr Biomed Res & Educ, Lab Neuroanat, Kanazawa, Ishikawa 9208640, Japan.
EM okoyama@med.kanazawa-u.ac.jp
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NR 45
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 72
EP 80
DI 10.1016/j.heares.2006.04.004
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000008
PM 16814970
ER
PT J
AU McDermott, HJ
Sucher, CM
AF McDermott, Hugh J.
Sucher, Catherine M.
TI Perceptual dissimilarities among acoustic stimuli and ipsilateral
electric stimuli
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; hearing aid; electro-acoustic stimulation
ID COCHLEAR IMPLANTATION; AUDITORY-SYSTEM; HEARING-LOSS
AB Five users of cochlear implants who had residual acoustic hearing in the implanted ear postoperatively participated in a study comparing the percepts elicited by acoustic and electric stimuli. The stimuli comprised pulse trains delivered to single electrodes and pure tones presented ipsilaterally. In the experiments, 12 equally loud stimuli with differing frequencies, electrode positions, and pulse rates were generated. Subjects listened to all of the possible pairs of stimuli in each set, and provided a relative dissimilarity rating for the members of each stimulus pair. The data were analyzed using non-metric multi-dimensional scaling techniques. Stimulus spaces were plotted in two dimensions to represent the results for each subject with each stimulus set. The results suggested that one dimension was associated with a pitch-like percept, related to the acoustic tone frequency and the active electrode position. The second dimension separated the acoustic stimuli from the electric stimuli. Generally, the electric pulse rate seemed to have a relatively small perceptual effect in this experimental context. Overall, the results show that acoustic pure tones are perceived as very different from electric pulse trains delivered to single electrode positions with constant rate, even when both the acoustic and the electric stimuli are presented to the same ear. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
RP McDermott, HJ (reprint author), Univ Melbourne, Dept Otolaryngol, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM hughm@unimelb.edu.au
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NR 17
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 81
EP 88
DI 10.1016/j.heares.2006.05.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000009
PM 16777362
ER
PT J
AU Takeda, T
Takeda, S
Kakigi, A
Okada, T
Nishioka, R
Taguchi, D
AF Takeda, Taizo
Takeda, Setsuko
Kakigi, Akinobu
Okada, Teruhiko
Nishioka, Rie
Taguchi, Daizo
TI A comparison of dehydration effects of V-2-antagonist (OPC-31260) on the
inner ear between systemic and round window applications
SO HEARING RESEARCH
LA English
DT Article
DE vasopressin; V-2-antagonist; OPC-31260; endolymphatic hydrops; Meniere's
disease
ID ENDOLYMPHATIC HYDROPS; MENIERES-DISEASE; ANTIDIURETIC-HORMONE;
ANTAGONIST OPC-31260; VASOPRESSIN; SAC; AQUAPORINS; EXPRESSION; RAT;
COCHLEA
AB V-2-antagonist (OPC-31260 (OPC)) application to the scala tympani reduced endolymphatic hydrops. In the present study, we investigated whether systemic administration or local infusion via the round window (RW application) of OPC would be more suitable for clinical use. In Experiment 1, the increase ratios of the cross-sectional area of the scala media of experimentally induced endolymphatic hydrops were quantitatively assessed among four groups of non-OPC application, RW application of xanthan gum, systemic application of OPC and RW application of OPC. In Experiment 2, the effects of systemic and RW applications of OPC on plasma vasopressin (p-VP) concentrations and plasma osmolality (p-OSM) were investigated. In Experiment 3, endocochlear DC potential (EP) was measured in guinea pigs with the RW application of OPC. Electron microscopic observations of the stria vascularis and the hair cells were also made. Both systemic and RW applications of OPC significantly reduced endolymphatic hydrops. However, systemic application resulted in the distension of the Reissner's membrane in the non-operated ear, which seemed to be caused by elevated p-VP levels resulting from the systemic application of OPC. In contrast, RW application of OPC produced no apparent toxic effects in the inner ear, as indicated electrophysiological or morphological changes. Thus, drug delivery via the round window is more useful for the clinical application of OPC for medical decompression. (c) 2006 Elsevier B.V. All rights reserved.
C1 Kochi Med Sch, Dept Otolaryngol, Nanko Ku, Kochi 7838505, Japan.
Kochi Med Sch, Dept Anat, Nanko Ku, Kochi 7838505, Japan.
RP Takeda, T (reprint author), Kochi Med Sch, Dept Otolaryngol, Nanko Ku, Oko Cho, Kochi 7838505, Japan.
EM takedat@med.kochi-u.ac.jp
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NR 28
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 89
EP 97
DI 10.1016/j.heares.2006.05.001
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000010
PM 16781097
ER
PT J
AU Stainsby, TH
Moore, BCJ
AF Stainsby, Thomas H.
Moore, Brian C. J.
TI Temporal masking curves for hearing-impaired listeners
SO HEARING RESEARCH
LA English
DT Article
DE temporal masking curves; forward masking; decay of masking; linear
temporal integrator; sensorineural hearing loss; reduced compression
ID BASILAR-MEMBRANE NONLINEARITY; TUNING CURVES; PERIPHERAL COMPRESSION;
COCHLEAR COMPRESSION; AUDITORY COMPRESSION; FREQUENCIES; MECHANICS;
ADDITIVITY; MODEL; AGE
AB The decay of forward masking was investigated for three subjects with moderate sensorineural hearing loss. For such subjects, compression on the basilar membrane (BM) is thought to be largely absent, enabling one to determine the decay of masking without the influence of compression. Temporal masking curves (TMCs), plots of the masker level at threshold against delay between masker offset and signal onset, were measured for delays of 0, 15, 30, 45, 60, and 75 ins, for signal frequencies, f(s), of 500, 1000, 2000, 4000, and 6000 Hz. Masker frequencies were 0.5, 0.8, 1.0, 1.15, and 1.3 times f(s). Most of the TMCs were well fitted with single-segment straight lines, which, except for high masker levels, were roughly parallel for each fs, supporting the belief that BM compression was largely absent in these subjects. However, the slopes of the TMCs were greater for f(s) = 500 and 1000 Hz than for higher frequencies, which may indicate that the decay of forward masking is not the same for all signal frequencies. The results suggest that it may not be valid to infer BM compression at low signal frequencies by using a reference TMC for a high f(s). (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
RP Stainsby, TH (reprint author), Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England.
EM ths22@cam.ac.uk
RI Moore, Brian/I-5541-2012
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NR 55
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2006
VL 218
IS 1-2
BP 98
EP 111
DI 10.1016/j.heares.2006.05.007
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 077LN
UT WOS:000240031000011
PM 16843625
ER
PT J
AU Rhode, WS
AF Rhode, William S.
TI Contributions of Aage Moller in the study of the cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE physiology using microelectrodes
ID UNIT RESPONSES; DYNAMIC PROPERTIES; MOSSBAUER TECHNIQUE;
BASILAR-MEMBRANE; SINGLE NEURONS; CAT; RAT; AMPLITUDE; TONES; NOISE
AB At a time when little was known about processing in the auditory system, Aage Moller undertook an extensive investigation of the response properties of cochlear nucleus (CN) neurons. With an excellent background in physiological acoustics and a command of computational techniques he systematically explored neural tuning, rate-level functions, and receptive fields of CN neurons using microelectrode recordings. He chose to employ more natural stimuli than just pure tones and employed a variety of stimuli consisting of tones, clicks, noise, amplitude- and frequency-modulated signals to document both intensity and temporal response characteristics.
The response to noise stimuli was quantified using linear systems analysis which was very innovative at that time. By choosing to perform the studies in the white rat rather than cat, he provided important comparative data on this first center of the central auditory system. Over a span of ten years he provided a significant body of observations of CN units properties that has rarely been equaled. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA.
RP Rhode, WS (reprint author), Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA.
EM rhode@neurophys.wisc.edu
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NR 36
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 2
EP 6
DI 10.1016/j.heares.2006.02.007
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300002
PM 16644161
ER
PT J
AU Recio-Spinoso, A
van Dijk, P
AF Recio-Spinoso, Alberto
van Dijk, Pim
TI Analysis of responses to noise in the ventral cochlear nucleus using
Wiener kernels
SO HEARING RESEARCH
LA English
DT Article
DE Wiener kernels; cochlear nucleus; nonlinear analysis
ID AUDITORY-NERVE FIBERS; SPECTROTEMPORAL RECEPTIVE-FIELDS;
FREQUENCY-SELECTIVITY; AMPLITUDE-MODULATION; PHASE-LOCKING; CAT;
NEURONS; STIMULI; CHINCHILLA; PATTERNS
AB Responses to noise were recorded in ventral cochlear nucleus (VCN) neurons of anesthetized chinchillas and cats, then analyzed using Wiener-kernel theory. First-order kernels, which are proportional to reverse-correlation functions, of primary-like (PL) and primary-like with notch (PLN) neurons having low characteristic frequency (CF) are similar to those obtained in auditory nerve fibers (ANFs). Such kernels consist of lightly damped transient oscillations with frequency equal to the neuron's CF. The first-order kernel of high-CF PL and PLN neurons displays no evidence of tuning to CF. Second-order kernels of the aforementioned VCN neuron types also resemble those in the nerve, irrespective of CF. In general, first- and second-order Wiener kernels of chopper neurons are similar to those obtained in high-CF ANFs. This is likely the consequence of the poor phase-locking capabilities to near-CF tones exhibited by chopper neurons. By analyzing second-order kernels using singular-value decomposition, it was possible to estimate group delays for the entire neuronal population, regardless of the neuron's type or CF. This was done by analyzing the highest-ranking singular vector (FSV). Amplitude values of FSVs in chopper neurons in the cat are substantially larger than in high-spontaneous ANFs. (c) 2006 Elsevier B.V. All rights reserved.
C1 Leiden Univ, Med Ctr, ENT Dept, NL-2300 RC Leiden, Netherlands.
Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA.
Univ Groningen, Med Ctr, Dept Otorhinolaryngol, Groningen, Netherlands.
Univ Groningen, Sch Behav & Cognit Neurosci, NL-9700 RB Groningen, Netherlands.
RP Recio-Spinoso, A (reprint author), Leiden Univ, Med Ctr, ENT Dept, POB 9600, NL-2300 RC Leiden, Netherlands.
EM a.recio@lumc.nl
RI Van Dijk, Pim/E-8019-2010; Recio-Spinoso, Alberto/F-7744-2013
OI Van Dijk, Pim/0000-0002-8023-7571;
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NR 37
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 7
EP 18
DI 10.1016/j.heares.2006.03.003
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300003
PM 16644154
ER
PT J
AU Joris, PX
Louage, DH
Cardoen, L
van der Heijden, M
AF Joris, Philip X.
Louage, Dries H.
Cardoen, Liesbeth
van der Heijden, Marcel
TI Correlation index: A new metric to quantify temporal coding
SO HEARING RESEARCH
LA English
DT Article
DE phase-locking; vector strength; temporal; correlogram; fine-structure;
envelope; revcor
ID AUDITORY-NERVE FIBERS; BROAD-BAND NOISE; ANTEROVENTRAL COCHLEAR NUCLEUS;
NEURONAL SPIKE TRAINS; INTERAURAL TIME SENSITIVITY; STOCHASTIC POINT
PROCESSES; AMPLITUDE-MODULATION; NEURAL SYNCHRONIZATION; INFERIOR
COLLICULUS; DYNAMIC PROPERTIES
AB The standard procedure to study temporal encoding Of Sound waveforms in the auditory system has been Fourier analysis of responses to periodic stimuli. We introduce a new metric-correlation index (CI)-which is based on a simple counting of spike coincidences. It can be used for responses to aperiodic stimuli and does not require knowledge of the stimulus. Moreover, the basic procedure of comparing spiketimes in spiketrains is more physiological than currently used methods for temporal analysis. The CI is the peak value of the normalized shuffled autocorrelogram (SAC), which provides a quantitative summary of temporal structure in the neural response to arbitrary stimuli. We illustrate the CI and SACs by comparing temporal coding in the auditory nerve and output fibers of the cochlear nucleus. (c) 2006 Elsevier B.V. All rights reserved.
C1 Katholieke Univ Leuven, Lab Auditory Neurophysiol, Sch Med, B-3000 Louvain, Belgium.
RP Joris, PX (reprint author), Katholieke Univ Leuven, Lab Auditory Neurophysiol, Sch Med, Campus Gasthuisberg 0&N Bus 1021,Herestr 49, B-3000 Louvain, Belgium.
EM philip.joris@med.kuleuven.be; Dries.Louage@med.kuleuven.be;
Liesbeth.Cardoen@student.kuleuven.ac.be;
Marcel.Vanderheyden@med.kuleuven.be
RI Joris, Philip/D-9608-2011
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NR 54
TC 42
Z9 44
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 19
EP 30
DI 10.1016/j.heares.2006.03.010
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300004
PM 16644160
ER
PT J
AU Needham, K
Paolini, AG
AF Needham, Karina
Paolini, Antonio G.
TI Neural timing, inhibition and the nature of stellate cell interaction in
the ventral cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE cochlear nucleus; stellate neurons; chopper cells; onset cells;
intracellular; commissural
ID GUINEA-PIG; GLYCINE IMMUNOREACTIVITY; RESPONSE PROPERTIES; COMMISSURAL
NEURONS; MULTIPOLAR CELLS; CHOPPER UNITS; CAT; REGULARITY; BRAIN; NOISE
AB The ventral cochlear nucleus (VCN) stellate cell population comprises two clusters: narrowly-tuned, excitatory T stellate neurons, and D stellate neurons, a broadly-tuned population of inhibitory cells. These neurons respond to best frequency (BF) tone bursts in a chopper or onset manner, respectively. Through extensive local and commissural projections the D stellate population provides a source of fast inhibitory input to both intrinsic and contralateral T stellate neurons. Whilst the nature of interactions between intrinsic stellate populations is difficult to examine, our previous intracellular investigations of the commissural pathway have provided a means by which to study this relationship in the in vivo preparation. It is the aim of this paper to both review and extend our understanding of the link between stellate populations and their involvement in the commissural pathway by presenting an overview of the results attained in our recently expanded study. The sample of 17 intracellular and 34 extracellular onset chopper (O(C)) and late/ideal (On(L)/On(1)) neurons revealed antidromic activity in 31.4% of neurons following contralateral stimulation, providing physiological evidence that On(L)/On(1) neurons also contribute projections to the commissural connection. Alternatively, 64.7/0 of the 34 intracellularly-recorded chopper neurons displayed fast, monosynaptic inhibitory potentials. This commissural input was found to influence the timing of neural activity in chopper neurons, providing insight into the relationship that exists between T and D stellate neurons. (c) 2006 Elsevier B.V. All rights reserved.
C1 La Trobe Univ, Sch Psychol Sci, Bundoora, Vic 3086, Australia.
Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
Bion Ear Inst, Melbourne, Vic 3002, Australia.
RP Paolini, AG (reprint author), La Trobe Univ, Sch Psychol Sci, Bundoora, Vic 3086, Australia.
EM kneedham@bionicear.org; a.paolini@latrobe.edu.au
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NR 57
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 31
EP 42
DI 10.1016/j.heares.2006.01.016
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300005
PM 16554129
ER
PT J
AU Verhey, JL
Winter, IM
AF Verhey, Jesko L.
Winter, Ian M.
TI The temporal representation of the delay of iterated rippled noise with
positive or negative gain by chopper units in the cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE multi-polar cell; pitch; inter-spike intervals; autocorrelation
ID AMPLITUDE-MODULATION; NEURONAL MECHANISMS; RESPONSE PROPERTIES; PITCH
STRENGTH; COMPLEX TONES; TIME-DOMAIN; CLASSIFICATION; CHINCHILLA;
REGULARITY; CAT
AB The role of chopper units in representing the pitch of complex sounds is unresolved. Traditionally chopper units have been regarded as primarily responding to the stimulus envelope of complex stimuli. This has been supported by the response of chopper units to iterated rippled noise (IRN) as they can provide a robust representation of the delay of IRN with positive gain (+) in their first-order interspike intervals and for some chopper units this representation is relatively level independent. The envelope modulation of IRN(+), and pitch, is at the reciprocal of the delay, the pitch of IRN with negative gain (IRN(-)) is often at twice the delay. This distinction between IRN(+) and IRN(-) can be used to help determine whether a unit is simply responding to modulation or to stimulus fine structure. Chopper units with relatively high best frequencies (1317) are unable to represent the distinction between IRN(+) and IRN(-). However, in this study it is shown that at least some chopper units, with low BFs (< 1.25 kHz), can represent the pitch of the IRN(-) as perceived perceptually. (c) 2006 Elsevier B.V. All rights reserved.
C1 Ctr Neural Basis Hearing, Physiol Lab, Cambridge CB2 3EG, England.
Univ Oldenburg, D-26111 Oldenburg, Germany.
RP Winter, IM (reprint author), Ctr Neural Basis Hearing, Physiol Lab, Downing St, Cambridge CB2 3EG, England.
EM imw1001@cam.ac.uk
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NR 23
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 43
EP 51
DI 10.1016/j.heares.2006.02.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300006
PM 16716545
ER
PT J
AU McGinley, MJ
Oertel, D
AF McGinley, Matthew J.
Oertel, Donata
TI Rate thresholds determine the precision of temporal integration in
principal cells of the ventral cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE ventral cochlear nucleus; synaptic integration; temporal coding;
temporal summation; integration window; action potential generation;
current ramp
ID AUDITORY-NERVE FIBERS; CA1 PYRAMIDAL NEURONS; RESPONSE PROPERTIES;
OCTOPUS CELLS; HORSERADISH-PEROXIDASE; LATERAL LEMNISCUS; COINCIDENCE
DETECTION; POTASSIUM CURRENTS; OUTWARD CURRENTS; UNIT RESPONSES
AB The three types of principal cells of the ventral cochlear nucleus (VCN), bushy, octopus, and T stellate, differ in the detection of coincidence among synaptic inputs. To explore the role of the action-potential-generation mechanism in the detection of coincident inputs, we examined responses to depolarizing currents that increased at varying rates. To fire an action potential, bushy cells, likely of the globular subtype, had to be depolarized faster than 4.8 +/- 2.8 mV/ms, octopus cells faster than 9.5 +/- 3.6 mV/ms, and T stellate cells fired irrespective of the rate of depolarization. The threshold rate of depolarization permitted definition of a time window over which depolarization could contribute to generating action potentials. This integration window differed between cell types. It was 5.3 +/- 1.8 ms for bushy cells and 1.4 +/- 0.3 ms for octopus cells. T Stellate cells fired action potentials in response to even slow depolarizations, showing that their integration window was unlimited so that temporal summation in these cells is limited by the time course of synaptic potentials. The rate of depolarization threshold in octopus and bushy cells was decreased by alpha-dendrotoxin while T stellate cells were largely insensitive to ot-dendrotoxin indicating that low-voltage-activated K(+) conductances (g(KL)) are important determinants of the integration window. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA.
RP Oertel, D (reprint author), Univ Wisconsin, Dept Physiol, 1300 Univ Ave, Madison, WI 53706 USA.
EM oertel@physiology.wisc.edu
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NR 91
TC 42
Z9 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 52
EP 63
DI 10.1016/j.heares.2006.02.006
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300007
PM 16647828
ER
PT J
AU Cant, NB
Benson, CG
AF Cant, Nell B.
Benson, Christina G.
TI Wisteria floribunda lectin is associated with specific cell types in the
ventral cochlear nucleus of the gerbil, Meriones unguiculatus
SO HEARING RESEARCH
LA English
DT Article
DE auditory system; octopus cells; multipolar cells; perineuronal nets
ID CALCIUM-BINDING PROTEINS; AUDITORY BRAIN-STEM; CHONDROITIN SULFATE
PROTEOGLYCANS; TERMINAL N-ACETYLGALACTOSAMINE; GLUTAMATE-RECEPTOR
SUBUNITS; CENTRAL-NERVOUS-SYSTEM; PERINEURONAL NETS; OCTOPUS CELLS;
EXTRACELLULAR-MATRIX; POTASSIUM CHANNEL
AB The cochlear nucleus is made up of a number of diverse cell types with different anatomical and physiological properties. A plant lectin, Wisteria floribunda agglutinin, that recognizes specific carbohydrate residues in the extracellular matrix binds to some cell types in the ventral cochlear nucleus but not to cells in the dorsal cochlear nucleus. In the ventral cochlear nucleus, the most intensely labeled cells are octopus cells, a subset of multipolar cells and cochlear root neurons. The multipolar cells that are labeled may correspond to the population that projects to the inferior colliculus. (c) 2006 Elsevier B.V. All rights reserved.
C1 Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA.
RP Cant, NB (reprint author), Duke Univ, Med Ctr, Dept Neurobiol, POB 3209,213 Bryan Res Bldg, Durham, NC 27710 USA.
EM nellcant@neuro.duke.edu
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NR 82
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 64
EP 72
DI 10.1016/j.heares.2006.01.008
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300008
PM 16497454
ER
PT J
AU Schofield, BR
Coomes, DL
AF Schofield, Brett R.
Coomes, Diana L.
TI Pathways from auditory cortex to the cochlear nucleus in guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE inferior colliculus; superior olivary complex; descending pathways;
efferent system
ID SUPERIOR OLIVARY COMPLEX; INFERIOR COLLICULUS; DESCENDING PROJECTIONS;
TRAPEZOID BODY; FINE-STRUCTURE; LARGE NEURONS; BRAIN-STEM; RAT;
ORGANIZATION; CELLS
AB The inferior colliculus (IC) and superior olivary complex (SOC) are important sources of descending pathways to the cochlear nucleus. The IC and SOC are also targets of direct projections from the auditory cortex but it is not known if cortical axons contact the cells that project to the cochlear nucleus. Multi-labeling techniques were used to address this question in guinea pigs. A fluorescent anterograde tracer was injected into temporal cortex to label corticofugal axons. Different fluorescent tracers were injected into one or both cochlear nuclei to label olivary and collicular cells. The brain was subsequently processed for fluorescence microscopy and the IC and SOC were examined for apparent contacts between cortical axons and retrogradely labeled cells. The results suggest that cortical axons contact cochlear nucleus-projecting cells in both IC and SOC. In both regions, contacts were more numerous on the side ipsilateral to the injected cortex. In the IC, the contacted cells projected ipsilaterally or contralaterally to the CN. In the SOC, the contacted cells projected ipsilaterally, contralaterally or bilaterally to the CN. We conclude that auditory cortex is in a position to modulate descending pathways from both the IC and SOC to the cochlear nucleus. (c) 2006 Elsevier B.V. All rights reserved.
C1 Northeastern Ohio Univ Coll Med & Pharm, Dept Neurobiol, Rootstown, OH 44272 USA.
RP Schofield, BR (reprint author), Northeastern Ohio Univ Coll Med & Pharm, Dept Neurobiol, 4209 State Route 44,POB 95, Rootstown, OH 44272 USA.
EM bschofie@neoucom.edu
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NR 51
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 81
EP 89
DI 10.1016/j.heares.2006.01.004
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300010
PM 16874906
ER
PT J
AU Shore, SE
Zhou, JX
AF Shore, Susan E.
Zhou, Jianxun
TI Somatosensory influence on the cochlear nucleus and beyond
SO HEARING RESEARCH
LA English
DT Article
DE auditory; cochlear nucleus; pathways; trigeminal; reticular formation;
somatosensory; non-auditory projections
ID TRIGEMINAL GANGLION STIMULATION; GUINEA-PIG; INFERIOR COLLICULUS;
HORSERADISH-PEROXIDASE; FUNCTIONAL-ORGANIZATION; SUBNUCLEUS
INTERPOLARIS; MICROSCOPIC FEATURES; RETROGRADE TRANSPORT;
RETICULAR-FORMATION; EXTERNAL NUCLEUS
AB Interactions between somatosensory and auditory systems occur at peripheral levels in the central nervous system. The cochlear nucleus (CN) receives innervation from trigeminal sensory structures: the ophthalmic division of the trigerninal ganglion and the caudal and interpolar regions of the spinal trigerninal nucleus (Sp51 and Sp5C). These projections terminate primarily in the granule cell domain, but also in magnocellular regions of the ventral and dorsal CN. Additionally, new evidence is presented demonstrating that cells in the lateral paragiganticular regions of the reticular formation (RE) also project to the CN. Not unlike the responses obtained from electrically stimulating the trigeminal system, stimulating RF regions can also result in excitation/inhibition of dorsal CN neurons. The origins and central connections of these projection neurons are associated with systems controlling vocalization and respiration. Electrical stimulation of trigeminal and RF projection neurons can suppress acoustically driven activity of not only CN neurons, but also neurons in the inferior colliculus. Together with the anatomical observations, these physiological observations suggest that one function of somatosensory input to the auditory system is to suppress responses to "expected" body-generated sounds such as vocalization or respiration. This would serve to enhance responses to "unexpected" external ly-generated sounds, such as the vocalizations of other animals. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Ann Arbor, MI 48109 USA.
RP Shore, SE (reprint author), Univ Michigan, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM sushore@umich.edu
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NR 56
TC 51
Z9 53
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 90
EP 99
DI 10.1016/j.heares.2006.01.006
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300011
PM 16513306
ER
PT J
AU Ryugo, DK
Montey, KL
Wright, AL
Bennett, ML
Pongstaporn, T
AF Ryugo, D. K.
Montey, K. L.
Wright, A. L.
Bennett, M. L.
Pongstaporn, T.
TI Postnatal development of a large auditory nerve terminal: The endbulb of
Held in cats
SO HEARING RESEARCH
LA English
DT Article
DE hearing; postsynaptic densities; puncta adherentia; synapses; synaptic
vesicles
ID ANTEROVENTRAL COCHLEAR NUCLEUS; DEAF WHITE CATS; PRIMARY AXOSOMATIC
ENDINGS; SPHERICAL BUSHY CELLS; FINE-STRUCTURE; ULTRASTRUCTURAL
ANALYSIS; VENTRAL COCHLEAR; BRAIN-STEM; SEQUENTIAL ALTERATIONS; NEURONAL
ARCHITECTURE
AB The endbulbs of Held are formed by the ascending branches of myelinated auditory nerve fibers and represent one of the largest synaptic endings in the brain. Most of the developmental changes in structure occur during the first 30 postnatal days of age. The neonatal endbulb begins as a flattened expansion with many filopodia, resembling a growth cone and characterized by numerous puncta adherentia and synapses associated with small postsynaptic densities; the most impressive feature of the ending at this age is its highly irregular plasma membrane that interdigitates with that of the postsynaptic spherical bushy cell. During these first 30 days, the number of puncta adherentia diminishes, postsynaptic densities nearly double in size, intermembraneous cisternae emerge, and plasma membranes flatten. These features endow the endbulb with an adult-like appearance. On the other hand, synaptic vesicle density increases progressively from approximately 50/mu m(2) at birth to 100/mu m(2) at adulthood. Mitochondria size remains constant over this developmental period but mitochondrial volume fraction increases until 60 days postnatal. Although many features of endbulb morphology stabilize by 30 days, other features suggest that endbulb development continues into the third month of age. Many of these observations correlate with the maturation of physiological response properties and suggest issues for further study. (c) 2006 Elsevier B.V. All rights reserved.
C1 Johns Hopkins Univ, Sch Med, Ctr Hearing & Balance, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA.
Johns Hopkins Univ, Sch Med, Ctr Hearing & Balance, Dept Neurosci, Baltimore, MD 21205 USA.
RP Ryugo, DK (reprint author), Johns Hopkins Univ, Sch Med, Ctr Hearing & Balance, Dept Otolaryngol Head & Neck Surg, 720 Rutland Ave,Traylor Res Bldg,Room 510, Baltimore, MD 21205 USA.
EM dryugo@bme.jhu.edu
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NR 65
TC 19
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 100
EP 115
DI 10.1016/j.heares.2006.01.007
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300012
PM 16497457
ER
PT J
AU Feng, JJ
Morest, DK
AF Feng, Jane J.
Morest, D. Kent
TI Development of synapses and expression of a voltage-gated potassium
channel in chick embryonic auditory nuclei
SO HEARING RESEARCH
LA English
DT Article
DE Kv3.1; translocation; nucleus magnocellularis; nucleus laminaris;
astrocyte; axon initial segment
ID FREQUENCY FIRING NEURONS; BRAIN-STEM; N-MAGNOCELLULARIS; COCHLEAR
NUCLEUS; UP-REGULATION; KV3 CHANNELS; K+ CHANNELS; SYSTEM; LAMINARIS;
CURRENTS
AB The potassium channel protein, Kv3.1, is abundantly expressed in the chick auditory pathway. Its b-isoform is found in nucleus magnocellularis, which receives the cochlear input, both before and after the establishment of synaptic connections. It is also present in cell cultures in the absence of any peripheral input. However, the expression of this isoform in the embryo has been shown to increase with development. Here, we address the question of the correlation between maturation of synapses in the auditory pathway and the pattern of expression of the b-isoform in a series of embryos prepared for immunohistochemistry at Hamburger-Hamilton stages equivalent to E10, E12, E14, and E17. We show here that this subunit translocates from the perinuclear cytoplasm to the cell membrane domain in nucleus magnocellularis at the time that cochlear nerve endings emerge as endbulbs of Held (E17). In nucleus laminaris, by this time, while abundant Kv3.1b occurs in the perinuclear cytoplasm, a translocation to the cell membrane domain has not yet occurred, and the mature peri-synaptic localization is delayed to a later stage. This difference suggests a hierarchy in the developmental expression of Kv3.1. An unexpected finding is the expression of the a-isoform of Kv3.1 in astrocytes, especially those which surround the developing nuclei and their connecting fibers. We also report here for the first time the presence of Kv3.1b in the initial segments of axons at the times when they begin to form. Our observations suggest that the Kv3.1 channel protein is regulated through mechanisms linked to the development of synaptic activity. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Connecticut, Ctr Hlth, Dept Neurosci, Farmington, CT 06030 USA.
So Connecticut State Univ, Dept Biol, New Haven, CT 06515 USA.
RP Morest, DK (reprint author), Univ Connecticut, Ctr Hlth, Dept Neurosci, Farmington, CT 06030 USA.
EM kentmorest@neuron.uchc.edu
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NR 54
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 116
EP 126
DI 10.1016/j.heares.2006.01.012
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300013
PM 16530363
ER
PT J
AU Harris, JA
Rubel, EW
AF Harris, Julie A.
Rubel, Edwin W.
TI Afferent regulation of neuron number in the cochlear nucleus: Cellular
and molecular analyses of a critical period
SO HEARING RESEARCH
LA English
DT Article
DE cochlear nucleus; critical period; microarray; deafferentation; neuron
death
ID STEM AUDITORY NUCLEI; UNILATERAL ODOR DEPRIVATION; BRAIN-STEM;
PROTEIN-SYNTHESIS; GENE-EXPRESSION; MAGNOCELLULARIS NEURONS;
INTRACELLULAR CALCIUM; ELECTRICAL-ACTIVITY; ACTION-POTENTIALS;
OLFACTORY-BULB
AB The neurons of the cochlear nucleus are dependent on input from the auditory nerve for survival during a critical period of development in a variety of vertebrate species. The molecules that underlie this age-dependent vulnerability to deafferentation are for the most part unknown, although recent studies have begun to yield interesting candidate genes. Here, we review the studies that originally described the presence of afferent dependent neuron survival in the cochlear nucleus and the age-dependency of this effect, as well as more recent work that seeks to understand the mechanisms underlying the neuron loss that occurs and the basis of this critical period. While much of the past work on cochlear nucleus neuronal susceptibility has been conducted looking at one or two genes at a time, recent advances in genomics make it possible to screen tens of thousands of genes while looking for candidate genes that are determinants of the critical period response to afferent deprivation. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Dept Otolaryngol Head & Neck Surg, Grad Program Neurobiol & Behav, Seattle, WA 98195 USA.
RP Rubel, EW (reprint author), Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Dept Otolaryngol Head & Neck Surg, Grad Program Neurobiol & Behav, CHDD Bldg,Rm CD176,Box 357923, Seattle, WA 98195 USA.
EM jharris1@u.washington.edu; rubel@u.washington.edu
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NR 63
TC 29
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 127
EP 137
DI 10.1016/j.heares.2006.03.016
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300014
PM 16874907
ER
PT J
AU Willott, JF
Bosch, JV
Shimizu, T
Ding, DL
AF Willott, James F.
Bosch, Justine Vanden
Shimizu, Toru
Ding, Da-Lian
TI Effects of exposing DBA/2J mice to a high-frequency augmented acoustic
environment on the cochlea and anteroventral cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE mice; sensorineural hearing loss; augmented acoustic environment;
cochlear nucleus; hair cells
ID CONDUCTIVE HEARING-LOSS; HAIR CELL LOSS; INFERIOR COLLICULUS; C57BL/6J
MICE; PROLONGED EXPOSURE; AUDITORY FUNCTION; AGE; MOUSE; STRAINS;
NEURONS
AB DBA/2.1 (D2) mice, which exhibit very early progressive sensorineural hearing loss, were treated for 12 h nightly with an augmented acoustic environment (AAE) initiated before the onset of hearing. The AAE consisted of repetitive bursts of a 70 dB sound pressure level, half-octave noise band centered at 20 kHz (i.e. low frequencies were excluded). At 55 days of age, AAE-treated mice, compared to control mice, exhibited less elevation of auditory brainstem response thresholds for tone frequencies from 16 to 32 kHz and fewer missing outer hair cells in the high-frequency tonotopic region of the cochlea, The dorsal region of their anteroventral cochlear nucleus (most strongly stimulated by the AAE) was larger, had more surviving neurons, and larger neurons than those of untreated control mice. These and previous findings using an AAE band containing lower frequencies indicate that AAE treatment effects are frequency-related. The findings provide support for the hypothesis that the beneficial effects of AAE treatment on the cochlea are associated with increased physiological activity evoked by the AAE, and the central AAE effects result from increased AAE-evoked neural activity and a healthier cochlea providing the auditory input. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ S Florida, Dept Psychol, Tampa, FL 33620 USA.
Jackson Lab, Bar Harbor, ME 04609 USA.
Univ Buffalo, Buffalo, NY USA.
RP Willott, JF (reprint author), Univ S Florida, Dept Psychol, 4202 E Fowler Ave,PCD4118G, Tampa, FL 33620 USA.
EM jimw@niu.edu
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NR 41
TC 7
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 138
EP 145
DI 10.1016/j.heares.2006.01.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300015
PM 16497456
ER
PT J
AU Holt, AG
Asako, M
Duncan, RK
Lomax, CA
Juiz, JM
Altschuler, RA
AF Holt, Avril Genene
Asako, Mikiya
Duncan, R. Keith
Lomax, Catherine A.
Juiz, Jose M.
Altschuler, Richard A.
TI Deafness associated changes in expression of two-pore domain potassium
channels in the rat cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE auditory; deafness; potassium channels; plasticity; cochlear nucleus
ID CEREBELLAR GRANULE CELLS; CENTRAL AUDITORY-SYSTEM; K+ CHANNEL; INFERIOR
COLLICULUS; ELECTRICAL-STIMULATION; FUNCTIONAL EXPRESSION; MUSCARINIC
INHIBITION; CEREBRAL-ISCHEMIA; NOISE EXPOSURE; SIZE CHANGES
AB Two-pore domain potassium channels (K-2PD(+)) play an important role in setting resting membrane potential by regulating background leakage of potassium ions, which in turn controls neuronal excitability. To determine whether these channels contribute to activitydependent plasticity following deafness, we used quantitative real-time PCR to examine the expression of 10 K-2PD(+), subunits in the rat cochlear nucleus at 3 days, 3 weeks and 3 months after bilateral cochlear ablation. There was a large sustained decrease in the expression of TASK-5, a subunit that is predominantly expressed in auditory brain stem neurons, and in the TASK-1 subunit which is highly expressed in several types of cochlear nucleus neurons. TWIK-1 and THIK-2 also showed significant decreases in expression that were maintained across all time points. TWIK-2, TREK-1 and TREK-2 showed no significant change in expression at 3 days but showed large decreases at 3 weeks and 3 months following deafness. TRAAK and TASK-3 subunits showed significant decreases at 3 days and 3 weeks following deafness, but these differences were no longer significant at 3 months. Dramatic changes in expression of K-2PD(+), subunits suggest these channels may play a role in deafness-associated changes in the excitability of cochlear nucleus neurons. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA.
Kansai Med Univ, Dept Otolaryngol, Osaka, Japan.
Univ Castilla La Mancha, Albacete 02071, Spain.
Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA.
RP Holt, AG (reprint author), Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol Head & Neck Surg, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM avrilhol@umich.edu
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NR 54
TC 26
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 146
EP 153
DI 10.1016/j.heares.2006.03.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300016
PM 16650703
ER
PT J
AU Rubio, ME
AF Rubio, Maria E.
TI Redistribution of synaptic AMPA receptors at glutamatergic synapses in
the dorsal cochlear nucleus as an early response to cochlear ablation in
rats
SO HEARING RESEARCH
LA English
DT Article
DE cochlear ablation; rat; electron microscopy; postembedding immunogold
labeling; AMPA receptors
ID STEM AUDITORY NUCLEI; BRAIN-STEM; GUINEA-PIG; DIFFERENTIAL DISTRIBUTION;
DESCENDING PROJECTIONS; HIPPOCAMPAL-NEURONS; CONGENITAL DEAFNESS;
OSSICLE REMOVAL; ACOUSTIC TRAUMA; FUSIFORM CELLS
AB This study investigated whether unilateral deafferentation of the presynaptic neuron is key in the control of morphology and the subunit composition and expression of AMPA type glutamate receptors (GluRs) in neurons of the dorsal cochlear nucleus (DCN). Data showed that there are morphological changes at the postsynaptic sites which precede presynaptic changes at the auditory nerve (AN) synaptic ending in response to peripheral damage, in particular that the postsynaptic densities (PSD) of the AN on fusiform cells (FC) are thicker after denervation. Moreover, GluR2, GluR3 and GluR4 AMPA receptor subunits were redistributed, not only at the synapse of FCs receiving direct contact with the AN, but also at the glutarnatergic synapse of the parallel fibers on FC and on cartwheel cells (CwC) which are indirectly innervated by the AN. Interestingly, the same synapses in the DCN contralateral to the lesion and with a normal AN synaptic input also redistributed AMPA receptor subunits at the synapse in respond to deafferentation. In these synapses, there was an increase of immunogold labeling for GluR2/3 subunits but not for GluR2 at 2 days after deafferentation. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA.
RP Rubio, ME (reprint author), Univ Connecticut, Dept Physiol & Neurobiol, 75 N Eagleville Rd, Storrs, CT 06269 USA.
EM maria.rubio@uconn.edu
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NR 64
TC 27
Z9 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 154
EP 167
DI 10.1016/j.heares.2006.03.007
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300017
PM 16644159
ER
PT J
AU Jin, YM
Godfrey, DA
Wang, J
Kaltenbach, JA
AF Jin, Yong-Ming
Godfrey, Donald A.
Wang, Jie
Kaltenbach, James A.
TI Effects of intense tone exposure on choline acetyltransferase activity
in the hamster cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE acetylcholinesterase; auditory; facial nerve; microdissection;
plasticity; tinnitus
ID SPONTANEOUS NEURAL ACTIVITY; SUPERIOR OLIVARY COMPLEX; OLIVOCOCHLEAR
NEURONS; ACOUSTIC TRAUMA; BRAIN-STEM; SOUND EXPOSURE; RAT; TINNITUS;
ACETYLCHOLINESTERASE; SYSTEM
AB Choline acetyltransferase (ChAT) activity has been mapped in the cochlear nucleus (CN) of control hamsters and hamsters that had been exposed to an intense tone. ChAT activity in most CN regions of hamsters was only a third or less of the activity in rat CN, but in granular regions ChAT activity was similar in both species. Eight days after intense tone exposure, average ChAT activity increased on the tone-exposed side as compared to the opposite side, by 74% in the anteroventral CN (AVCN), by 5511,, in the granular region dorsolateral to it, and by 74% in the deep layer of the dorsal CN (DCN). In addition, average ChAT activity in the exposed-side AVCN and fusiform soma layer of DCN was higher than in controls, by 152% and 67%, respectively. Two months after exposure, average ChAT activity was still 53% higher in the exposed-side deep layer of DCN as compared to the opposite side. Increased ChAT activity after intense tone exposure may indicate that this exposure leads to plasticity of descending cholinergic innervation to the CN, which might affect spontaneous activity in the DCN that has been associated with tinnitus. (c) 2006 Elsevier B.V. All rights reserved.
C1 Med Univ Ohio, Dept Surg, Div Otolaryngol, Toledo, OH 43614 USA.
Wayne State Univ, Dept Otolaryngol, Detroit, MI USA.
RP Godfrey, DA (reprint author), Med Univ Ohio, Dept Surg, Div Otolaryngol, 3065 Arlington Ave, Toledo, OH 43614 USA.
EM dgodfrey@meduohio.edu
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NR 57
TC 26
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 168
EP 175
DI 10.1016/j.heares.2006.02.002
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300018
PM 16549284
ER
PT J
AU Ma, WLD
Young, ED
AF Ma, Wei-Li Diana
Young, Eric D.
TI Dorsal cochlear nucleus response properties following acoustic trauma:
Response maps and spontaneous activity
SO HEARING RESEARCH
LA English
DT Article
DE dorsal cochlear nucleus; acoustic trauma; response maps; spontaneous
activity
ID STEM AUDITORY NUCLEI; COMPLEX-SPIKING NEURONS; SPONTANEOUS NEURAL
ACTIVITY; INFERIOR COLLICULUS; BRAIN-STEM; GUINEA-PIG;
ELECTRICAL-STIMULATION; INTENSE SOUND; NERVE FIBERS; HEARING-LOSS
AB Recordings from single neurons in the dorsal cochlear nucleus (DCN) of unanesthetized (decerebrate) cats were done to characterize the effects of acoustic, trauma. Trauma was produced by a 250 Hz band of noise centered at 10 kHz, presented at 105-120 dB SPL for 4 h. After a one-month recovery period, neurons were recorded in the DCN. The threshold shift, determined from compound action-potential audiograms, showed a sharp threshold elevation of about 60 dB at BFs above an edge frequency of 5-10 kHz. The response maps of neurons with best frequencies (BFs) above the edge did not show the typical organization of excitatory and inhibitory areas seen in the DCN of unexposed animals. Instead, neurons showed no response to sound, weak responses that were hard to tune and characterize, or "tail" responses, consisting of broadly-tuned, predominantly excitatory responses, with a roughly low-pass shape similar to the tuning curves of auditory nerve fibers with similar threshold shifts. In some tail responses whose BFs were near the edge of the threshold elevation, a second weak high-frequency response was seen that suggests convergence of auditory nerve inputs with widely separated BFs on these cells. Spontaneous rates among neurons with elevated thresholds were not increased over those in populations of principal neurons in unexposed animals. (c) 2006 Elsevier B.V. All rights reserved.
C1 Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA.
Johns Hopkins Univ, Ctr Hearing & Balance, Baltimore, MD 21205 USA.
RP Young, ED (reprint author), Johns Hopkins Univ, Dept Biomed Engn, 505 Traylor Res Bldg,720 Rutland Ave, Baltimore, MD 21205 USA.
EM dma@bme.jhu.edu; eyoung@jhu.edu
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NR 90
TC 24
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 176
EP 188
DI 10.1016/j.heares.2006.03.011
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300019
PM 16630701
ER
PT J
AU Illing, RB
Reisch, A
AF Illing, Robert-Benjamin
Reisch, Adrian
TI Specific plasticity responses to unilaterally decreased or increased
hearing intensity in the adult cochlear nucleus and beyond
SO HEARING RESEARCH
LA English
DT Article
DE synaptic remodeling; cochlear lesion; cochlear implant; GAP-43; c-Fos
ID AUDITORY BRAIN-STEM; ELECTRICAL INTRACOCHLEAR STIMULATION; LONG-TERM
POTENTIATION; IMMEDIATE-EARLY GENES; C-FOS; OLIVOCOCHLEAR NEURONS;
TRANSCRIPTION FACTORS; MESSENGER-RNA; EXPRESSION; RAT
AB Variations of sensory activation in strength and pattern are known to affect structure and function of the mammalian brain. Whereas such malleability is readily granted to forebrain structures at early developmental stages, acceptance of experience-dependent structural plasticity has been slow for the adult brainstem. Over the past years we have identified consequences of cochlear ablation, noise trauma., or electrical intracochlear stimulation on neurons and circuitry of the auditory brainstem of the adult rat. We found that loss of sensory activation as well as a substitution for it entail specific molecular, ultrastructural, and morphological changes to central auditory neurons. Here, we make a first attempt to compare these different patterns of central remodeling. We tentatively suggest that after hearing loss or intracochlear stimulation responses of the central neural network in the adult brainstem suit the concept of functional adaptation. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Freiburg, Dept Otorhinolaryngol, Neurobiol Res Lab, D-79106 Freiburg, Germany.
RP Illing, RB (reprint author), Univ Freiburg, Dept Otorhinolaryngol, Neurobiol Res Lab, Killianstr 5, D-79106 Freiburg, Germany.
EM robert.illing@uniklinik-freiburg.de
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NR 32
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 189
EP 197
DI 10.1016/j.heares.2005.12.014
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300020
PM 16624512
ER
PT J
AU Idrizbegovic, E
Salman, H
Niu, XZ
Canlon, B
AF Idrizbegovic, Esma
Salman, Hazim
Niu, Xianzhi
Canlon, Barbara
TI Presbyacusis and calcium-binding protein immunoreactivity in the
cochlear nucleus of BALB/c mice
SO HEARING RESEARCH
LA English
DT Article
DE hair cells; spiral ganglion neurons; calbindin; calretinin; parvalbumin;
aging; presbycusis
ID AUDITORY BRAIN-STEM; CALBINDIN D-28K IMMUNOREACTIVITY; INDUCED
HEARING-LOSS; INFERIOR COLLICULUS; CBA/CAJ MICE; F1-HYBRID STRAINS;
INBRED STRAINS; NERVOUS-SYSTEM; UP-REGULATION; CELL-DEATH
AB The BALB/c mouse is an established model for the early development of sensorineural hearing loss, and is homozygous for the Ah1 allele (age-related hearing loss). The present study was designed to determine how auditory peripheral pathology influences calcium-binding protein immunoreactivity in the cochlear nucleus in aged BALB/c mice. To address this issue the loss of hair cells, spiral ganglion neurons (SGN), and neurons in the dorsal (DCN) and posteroventral (PVCN) cochlear nucleus of BALB/c mice at 1 and 24 months of age were quantified using CAST stereological methods. These values were then compared to the percent increase in immunopositive calcium-binding proteins in the cochlear nucleus. By 24 months of age there was a near complete loss of all outer hair cells (OHC). The inner hair cell (IHC) loss was near complete in the more apical and basal regions, while in the mid-regions approximately 50% were missing. The SGN in the apical and middle turns show a 20% loss (re: 1 month) and the basal turn up to 80% loss. A statistically significant decrease in the density of DCN and PVCN neurons (25%) was found at 24 months of age compared to the one month old animals. The percentage of parvalbumin and calretinin positive neurons in the DCN and the PVCN in relation to the density of Nissl stained neurons showed significant increases at 24 months compared to the 1 month old animals. We also determine the relationship between peripheral pathology and the percent increase in calcium-binding protein immunoreactivity. In the DCN, the percent increase of calretinin and parvalbumin was correlated to the loss of SGN, IHCs and OHCs. In the PVCN, parvalbumin was correlated to SGN, IHC, and OHC loss. The percent increase in calbindin immunoreactivity was not correlated to any peripheral pathology. The data here suggest a percent increase in calcium-binding protein immunoreactivity in the cochlea nucleus in the 24 month old mice may reflect an endogenous protective strategy that is designed to counteract calcium overload that is prominent during aging and degeneration. These results will be valuable for understanding the relationship among the peripheral and central auditory system in a model demonstrating a rapidly progressive presbyacusis. (c) 2006 Elsevier B.V. All rights reserved.
C1 Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
Karlinska Univ Hosp, Dept Audiol, Stockholm, Sweden.
RP Canlon, B (reprint author), Karolinska Inst, Dept Physiol & Pharmacol, Eulers Vag 8, S-17177 Stockholm, Sweden.
EM Barbara.Canlon@fyfa.ki.se
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NR 40
TC 16
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 198
EP 206
DI 10.1016/j.heares.2006.01.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300021
PM 16874908
ER
PT J
AU Caspary, DA
Hughes, LF
Schatteman, TA
Turner, JG
AF Caspary, Donald A.
Hughes, Larry F.
Schatteman, Tracy A.
Turner, Jeremy G.
TI Age-related changes in the response properties of cartwheel cells in rat
dorsal cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE auditory; aging; cartwheel cells; dorsal cochlear nucleus; response
properties
ID COMPLEX-SPIKING NEURONS; PARALLEL FIBER STIMULATION; LABELED FUSIFORM
CELLS; HEARING-LOSS; GUINEA-PIG; INFERIOR COLLICULUS; SPEECH
RECOGNITION; AUDITORY-SYSTEM; FISCHER-344 RAT; DISCHARGE CHARACTERISTICS
AB The fusiform cell and deep layers of the dorsal cochlear nucleus (DCN) show neurotransmitter and functional age-related changes suggestive of a downregulation of inhibitory efficacy onto DCN output neurons. Inhibitory circuits implicated in these changes include vertical and D-multipolar cells. Cartwheel cells comprise a large additional population of DCN inhibitory neurons. Cartwheel cells receive excitatory inputs from granule cell parallel fibers and provide a source of glycinergic inhibitory input onto apical dendrites of DCN fusiform cells. The present study compared the response properties from young and aged units meeting cartwheel-cell criteria in anesthetized rats. Single unit recordings from aged cartwheel cells revealed significantly higher thresholds, increased spontaneous activity and significantly altered rate-level functions characterized by hyperexcitability at higher intensities. Aged cartwheel cells showed a significant reduction in off-set suppression. Collectively, these findings suggest a loss of tonic and perhaps response inhibition onto aged DCN cartwheel neurons. These changes likely reflect a compensatory downregulation of synaptic inhibition in response to a loss of excitatory drive from auditory and non-auditory excitatory inputs via granule cells. The impact of increased excitability of cartwheel cells on DCN output neurons is likely to be complex, influenced by loss of glycinergic release and/or subunit receptor changes which would only partially off-set age-related loss of inhibition onto the somata and basal dendrites of fusiform cells. (c) 2006 Elsevier B.V. All rights reserved.
C1 So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA.
So Illinois Univ, Sch Med, Dept Surg, Springfield, IL 62794 USA.
RP Caspary, DA (reprint author), So Illinois Univ, Sch Med, Dept Pharmacol, POB 19629, Springfield, IL 62794 USA.
EM dcaspary@siumed.edu
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NR 81
TC 17
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 207
EP 215
DI 10.1016/j.heares.2006.03.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300022
PM 16644158
ER
PT J
AU Frisina, RD
Walton, JP
AF Frisina, Robert D.
Walton, Joseph P.
TI Age-related structural and functional changes in the cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE presbycusis; glycine; auditory brainstem; central auditory system; aging
ID SENSORINEURAL HEARING-LOSS; INFERIOR COLLICULUS; CBA/J MICE; FISCHER-344
RATS; SYNAPTIC CHANGES; AGING C57BL/6J; MOUSE; YOUNG; MORPHOLOGY;
INHERITANCE
AB Presbycusis - age-related hearing loss - is a key communication disorder and chronic medical condition of our aged population. The cochlear nucleus is the major site of projections from the auditory portion of the inner ear. Relative to other levels of the peripheral and central auditory systems, relatively few studies have been conducted examining age-related changes in the cochlear nucleus. The neurophysiological investigations suggest declines in glycine-mediated inhibition, reflected in increased firing rates in cochlear nucleus neurons from old animals relative to young adults. Biochemical investigations of glycine inhibition in the cochlear nucleus are consistent with the functional aging declines of this inhibitory neurotransmitter system that affect complex sound processing. Anatomical reductions in neurons of the cochlear nucleus and their output pathways can occur due to aging changes in the brain, as well as due to age-dependent plasticity of the cochlear nucleus in response to the age-related loss of inputs from the cochlea, particularly from the basal, high-frequency regions. Novel preventative and curative biomedical interventions in the future aimed at alleviating the hearing loss that comes with age, will likely emanate from increasing our knowledge and understanding of its neural and molecular bases. To the extent that this sensory deficit resides in the central auditory system, including the cochlear nucleus, future neural therapies will be able to improve hearing in the elderly. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Rochester, Sch Med & Dent, Dept Otolaryngol, Rochester, NY 14642 USA.
Rochester Inst Technol, Natl Tech Inst Deaf, Int Ctr Hearing & Speech Res, Rochester, NY 14623 USA.
Univ Rochester, Sch Med & Dent, Dept Neurobiol, Rochester, NY 14642 USA.
Univ Rochester, Sch Med & Dent, Dept Anat & Biomed Engn, Rochester, NY 14642 USA.
RP Frisina, RD (reprint author), Univ Rochester, Sch Med & Dent, Dept Otolaryngol, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM rdf@q.ent.rochester.edu
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NR 29
TC 27
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN-JUL
PY 2006
VL 216
BP 216
EP 223
DI 10.1016/j.heares.2006.02.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 064NL
UT WOS:000239096300023
PM 16597491
ER
PT J
AU Excoffon, KJDA
Avenarius, MR
Hansen, MR
Kimberling, WJ
Najmabadi, H
Smith, RJH
Zabner, J
AF Excoffon, KJDA
Avenarius, MR
Hansen, MR
Kimberling, WJ
Najmabadi, H
Smith, RJH
Zabner, J
TI The Coxsackievirus and Adenovirus Receptor: A new adhesion protein in
cochlear development
SO HEARING RESEARCH
LA English
DT Article
DE Coxsackievirus and Adenovirus Receptor; CAR; CXADR; usher syndrome;
deafness; cochlea
ID MEDIATED GENE-TRANSFER; INNER-EAR; USHER-SYNDROME; HAIR-CELLS;
RESPIRATORY VIRUSES; OTITIS-MEDIA; B VIRUS; CAR; EXPRESSION; THERAPY
AB The Coxsackievirus and Adenovirus Receptor (CAR) is an essential regulator of cell growth and adhesion during development. The gene for CAR, CXADR, is located within the genomic locus for Usher syndrome type 1E (USH1E). Based on this and a physical interaction with harmonin, the protein responsible for USH1C, we hypothesized that CAR may be involved in cochlear development and that mutations in CXADR may be responsible for USH1E. The expression of CAR in the cochlea was determined by PCR and immunofluorescence microscopy. We found that CAR expression is highly regulated during development. In neonatal mice, CAR is localized to the junctions of most cochlear cell types but is restricted to the supporting and strial cells in adult cochlea. A screen of two populations consisting of non-syndromic deaf and Usher 1 patients for mutations in CXADR revealed one haploid mutation (P356S). Cell surface expression, viral receptor activity, and localization of the mutant form of CAR were indistinguishable from wild-type CAR. Although we were unable to confirm a role for CAR in autosomal recessive, non-syndromic deafness, or Usher syndrome type 1, based on its regulation, localization, and molecular interactions, CAR remains an attractive candidate for genetic deafness. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
Univ Iowa, Dept Internal Med, Div Pulm Med, Iowa City, IA 52242 USA.
Boys Town Natl Res Hosp, Ctr Hereditary Commun Disorders, Omaha, NE 68131 USA.
Social Welf & Rehabil Sci Univ, Genet Res Ctr, Tehran, Iran.
Univ Iowa, Interdept PhD Program Genet, Iowa City, IA 52242 USA.
RP Smith, RJH (reprint author), Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
EM richard-smith@uiowa.edu; joseph-zabner@uiowa.edu
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NR 38
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2006.02.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900001
PM 16678988
ER
PT J
AU Cartee, LA
Miller, CA
van den Honert, C
AF Cartee, LA
Miller, CA
van den Honert, C
TI Spiral ganglion cell site of excitation I: Comparison of scala tympani
and intrameatal electrode responses
SO HEARING RESEARCH
LA English
DT Article
DE auditory nerve; cats; cochlear implant; electrical stimulation; single
fiber recording
ID AUDITORY-NERVE FIBERS; COCHLEAR NEURAL MEMBRANE; ELECTRICAL-STIMULATION;
PHYSIOLOGICAL-PROPERTIES; GUINEA-PIG; CAT; NEURONS; RECORDINGS;
POTENTIALS; PATTERNS
AB To determine the site of excitation on the spiral ganglion cell in response to electrical stimulation similar to that from a cochlear implant, single-fiber responses to electrical stimuli delivered by an electrode positioned in the scala tympani were compared to responses from stimuli delivered by an electrode placed in the internal auditory meatus. The response to intrameatal stimulation provided a control set of data with a known excitation site, the central axon of the spiral ganglion cell. For both intrameatal and scala tympani stimuli, the responses to single-pulse, summation, and refractory stimulus protocols were recorded. The data demonstrated that summation pulses, as opposed to single pulses, are likely to give the most insightful measures for determination of the site of excitation. Single-fiber summation data for both scala tympani and intrameatally stimulated fibers were analyzed with a clustering algorithm. Combining cluster analysis and additional numerical modeling data, it was hypothesized that the scala tympani responses corresponded to central excitation, peripheral excitation adjacent to the cell body, and peripheral excitation at a site distant from the cell body. Fibers stimulated by an intrameatal electrode demonstrated the greatest range of jitter measurements indicating that greater fiber independence may be achieved with intrameatal stimulation. (c) 2006 Elsevier B.V. All rights reserved.
C1 N Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27695 USA.
Univ N Carolina, Chapel Hill, NC USA.
Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52240 USA.
Cochlear Amer Englewood, Englewood, CO USA.
RP Cartee, LA (reprint author), N Carolina State Univ, Joint Dept Biomed Engn, 2110 Faucette Dr,118 Weaver Labs,Box 7625, Raleigh, NC 27695 USA.
EM lacartee@ncsu.edu
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NR 34
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 10
EP 21
DI 10.1016/j.heares.2006.02.012
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900002
PM 16624511
ER
PT J
AU Cartee, LA
AF Cartee, LA
TI Spiral ganglion cell site of excitation II: Numerical model analysis
SO HEARING RESEARCH
LA English
DT Article
DE auditory neuron; cochlear implant; electrical stimulation;
Hodgkin-Huxley equations; neural model
ID ELECTRICAL-STIMULATION; MYELINATED NERVE; AUDITORY-NERVE; NEURONS;
PROPAGATION; POTENTIALS; MEMBRANE; CATS
AB An anatomically based model of cochlear neuron electrophysiology has been developed and used to interpret the physiological responses of the auditory neuron to electrical summation and refractory pulse-pair stimuli. For summation pulses, the summation time constant, is tau(sum), indicates the ability of the membrane to hold charge after cessation of a pulse. When a spiral ganglion cell with a cell body was simulated, the value of tau(sum) was elevated at the peripheral node adjacent to the cell body. For refraction pulses, the refraction time constant, tau(ref), indicates the duration of the relative refractory period of the membrane. In spiral ganglion cell simulations, tau(ref) was decreased at the peripheral node adjacent to the cell body and slightly elevated at other peripheral nodes. The extent of the cell body influence on tau(sum) and tau(ref) was high localized. Excitation times for the nodes adjacent to the cell body were either simultaneous or near simultaneous resulting in similar response latencies. Results indicate that values of tau(sum) and tau(ref) may be useful for distinguishing central and peripheral excitation sites while latency measures alone are not a good indication of site of excitation. (c) 2006 Elsevier B.V. All rights reserved.
C1 N Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27695 USA.
Univ N Carolina, Chapel Hill, NC USA.
RP Cartee, LA (reprint author), N Carolina State Univ, Joint Dept Biomed Engn, Box 7625, Raleigh, NC 27695 USA.
EM lacartee@ncsu.edu
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NR 23
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 22
EP 30
DI 10.1016/j.heares.2006.02.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900003
PM 16624510
ER
PT J
AU Mazurek, B
Amarjargal, N
Haupt, H
Gross, J
AF Mazurek, B
Amarjargal, N
Haupt, H
Gross, J
TI High potassium concentrations protect inner and outer hair cells in the
newborn rat culture from ischemia-induced damage
SO HEARING RESEARCH
LA English
DT Article
DE potassium; ischemia; hair cell loss; newborn rat; organ of Corti culture
ID PLASMA-MEMBRANE CA2+-ATPASE; CALCIUM-PUMP ACTIVITY; GUINEA-PIG; CA2+
HOMEOSTASIS; SENSORY CELLS; CHANNELS; DEPOLARIZATION; NEURONS; COCHLEA;
DEATH
AB Several studies indicate that an increase in the extracellular potassium (K+) concentration is a factor exerting a damaging effect on cochlear hair cells (HCs). The present study was designed to examine the effects of high extracellular K+ concentrations on the HCs under normoxic and ischemic conditions. Organotypic cultures of the organ of Corti of newborn rats were exposed to normoxia and ischemia at K+ concentrations of 5-70 mM in artificial perilymph for 3-4 h. The number of IHCs and OHCs in the apical, medial and basal parts of the cochlea were counted 24 h later. The work resulted in two main findings: (1) extracellular K+ concentrations of 30-70 mM had no effect on the HCs under normoxic conditions: (2) tinder ischemic conditions, a clear HC loss. mainly in the medial and basal cochlear parts, was observed at 5 mM K+ as previously reported. In contrast, a high extracellular K+ concentration strongly attenuated the HC loss. This effect nearly completely disappeared by the addition of both eosin, an inhibitor of the plasma membrane calcium ATPase (PMCA), and linopirdine, an inhibitor of the KCNQ4 channel, indicating that a normal activity of the PMCA and the KCNQ4 channels are key factors for HC survival under ischemia and depolarizing conditions. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Med Berlin, Charite, Dept Otorhinolaryngol, Mol Biol Res Lab, D-14050 Berlin, Germany.
RP Gross, J (reprint author), Univ Med Berlin, Charite, Dept Otorhinolaryngol, Mol Biol Res Lab, Spandauer Damm 130 Bld 31, D-14050 Berlin, Germany.
EM birgit.mazurek@charite.de; nyamaa.amra@charite.de;
heidemarie.haupt@charite.de; johann.gross@charite.de
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NR 40
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 31
EP 38
DI 10.1016/j.heares.2006.02.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900004
PM 16678987
ER
PT J
AU Braun, M
AF Braun, M
TI A retrospective study of the spectral probability of spontaneous
otoacoustic emissions: Rise of octave shifted second mode after infancy
SO HEARING RESEARCH
LA English
DT Article
DE spontaneous otoacoustic emission; medial olivocochlear system; neonate;
octave
ID ACTIVE MICROMECHANICAL PROPERTIES; SPONTANEOUS CELLULAR VIBRATIONS;
DISTORTION-PRODUCT; NON-MUSICIANS; SELECTIVE ATTENTION; EAR RESONANCE;
COCHLEA; SENSITIVITY; PREVALENCE; AMPLITUDE
AB The recording of otoacoustic emissions (OAEs) is today a widely used tool in medical diagnosis. The mechanisms of OAE generation in the cochlea and their transmission to the external ear canal, however, are not well understood and a matter of long-standing debates. Here, the frequency distribution of 1660 spontaneous otoacoustic emissions (SOAEs) from three surveys, covering 296 human subjects, is analyzed. Neonates show a monomodal distribution with a peak at 4 kHz. but both children (5-11 y) and adults show an identical bimodal distribution, with two peaks in an octave distance (1.5 and 3 kHz). For the combined children and adult data, distribution density at the two peak tops is 2.8 and 2.7 times as high as at the low between them. Mean SOAE amplitudes are unrelated to the two peaks, but show a significant narrow-band dip precisely at the low in between at 2140 Hz (P < 0.008). External ear canal resonance can explain the single 4 kHz mode at birth and the 3 kHz mode in children and adults. The octave shifted 1.5 kHz mode remains without mechanical explanation. It may reflect descending neural influence from central octave band processing. The results are relevant for the interpretation of OAE levels in medical diagnosis. (c) 2006 Elsevier B.V. All rights reserved.
C1 Neurosci Mus, S-67195 Klassbol, Sweden.
RP Braun, M (reprint author), Neurosci Mus, Gamsbyn 14, S-67195 Klassbol, Sweden.
EM nombraun@telia.com
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NR 49
TC 5
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 39
EP 46
DI 10.1016/j.heares.2006.03.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900005
PM 16644155
ER
PT J
AU Prado-Guitierrez, P
Fewster, LM
Heasman, JM
Mckay, CM
Shepherd, RK
AF Prado-Guitierrez, P
Fewster, LM
Heasman, JM
Mckay, CM
Shepherd, RK
TI Effect of interphase gap and pulse duration on electrically evoked
potentials is correlated with auditory nerve survival
SO HEARING RESEARCH
LA English
DT Article
DE neural degeneration; deafness; electrical stimulation; cochlear implant;
neural prostheses; EABR; ECAP
ID SENSORINEURAL HEARING-LOSS; PSYCHOPHYSICAL DETECTION THRESHOLDS;
COCHLEAR IMPLANT USERS; FUNCTIONAL-RESPONSES; SPIRAL GANGLION;
GUINEA-PIGS; BRAIN-STEM; IN-VIVO; STIMULATION; SINGLE
AB We investigated the effect of pulse duration (PD) and interphase-gap (IPG) on the electrically-evoked auditory brain stem response (EABR) and viiith nerve compound action potential (ECAP) of deafened guinea pigs in order to test the hypothesis that the extent of change in these neural responses is affected by the histological status of the auditory nerve. Fifteen guinea pigs were deafened by coadministration of kanamycin and furosemide. Animals were acutely implanted with an 8-band electrode array at 1, 4 or 12 weeks following deafening. EABR and ECAP input/output functions were recorded in response to charge balanced biphasic current pulses. We determined the change in current required to equalize; (i) the EABR amplitude when the duration of the current pulse was doubled (104208 mu s/phase); and (ii) the EABR and ECAP amplitudes when the IPG was increased from 8 to 58 mu s using a 104 mu s/phase current pulse. Following the completion of each experiment the cochleae were examined quantitatively for spiral ganglion neuron survival. As expected, the current level required to evoke an EABR with equal amplitude was lower when the animal was stimulated with current pulses of 208 compared with 104 mu s/phase. Moreover, the current level required to evoke EABR/ECAPs with equal amplitude was lower when current pulses had an IPG of 58 versus 8 mu s. Importantly, there was a reduction in the magnitude of this effect with greater neural loss; the reduced efficacy of changing both PD and IPG on these electrically-evoked potentials was statistically correlated with neural survival. These results may provide a tool for investigating the contribution of auditory nerve survival to clinical performance among cochlear implant subjects. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Dept Otolaryngol, Parkville, Vic 3052, Australia.
Bion Ear Inst, Melbourne, Vic 3002, Australia.
RP Shepherd, RK (reprint author), Univ Melbourne, Dept Otolaryngol, Parkville, Vic 3052, Australia.
EM rshepherd@bionicear.org
RI Shepherd, Robert/I-6276-2012
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NR 44
TC 35
Z9 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 47
EP 55
DI 10.1016/j.heares.2006.03.006
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900006
PM 16644157
ER
PT J
AU Wu, CH
Jen, PHS
AF Wu, CH
Jen, PHS
TI The role of GABAergic inhibition in shaping duration selectivity of bat
inferior collicular neurons determined with temporally patterned sound
trains
SO HEARING RESEARCH
LA English
DT Article
DE bat; bicuculline; duration selectivity; GABA; pulse repetition rate;
pulse trains
ID BIG BROWN BAT; EPTESICUS-FUSCUS; TUNING CHARACTERISTICS; PULSE TRAINS;
GLYCINERGIC INHIBITION; SPACE REPRESENTATION; RESPONSE PROPERTIES;
AUDITORY MIDBRAIN; REPETITION RATE; FM BAT
AB A previous study has shown that duration selectivity of neurons in the inferior colliculus (IC) of the big brown bat, Eptesicus fuscus becomes sharper with increasing pulse repetition rate (PRR). The present study examines the role of GABAergic inhibition in improving duration selectivity of bat IC neurons with PRR by means of iontophoretic application of GABA as well as its antagonist, bicuculline. Duration selectivity of IC neurons is studied by plotting the duration tuning curves with the number of impulses per pulse against the pulse duration. Duration tuning curves of IC neurons are described as band-, short-, long- and all-pass in terms of filtering properties to sound duration. Bicuculline application produces more pronounced broadening of duration tuning curves at high than at low PRR. Conversely, GABA application produces more pronounced narrowing of duration tuning curves at low than at high PRR. In either case, sharpening of duration selectivity of IC neurons with increasing PRR is abolished during drug application. The duration tuning curves of IC neurons progressively broadens with recording depth. Broadening of duration tuning curves during bicuculline application is more pronounced for neurons at upper than at deep IC. This progressive decrease in duration selectivity with recording depth is discussed in relation to spatial distribution gradient of GABA(A) receptors in the IC. Possible biological significance of these findings relevant to bat echolocation is discussed. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
Univ Missouri, Intedisciplinary Neurosci Program, Columbia, MO 65211 USA.
RP Jen, PHS (reprint author), Univ Missouri, Div Biol Sci, 208 Lefevre Hall, Columbia, MO 65211 USA.
EM jenp@missouri.edu
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NR 48
TC 13
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 56
EP 66
DI 10.1016/j.heares.2006.03.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900007
PM 16644156
ER
PT J
AU Sigalovsky, IS
Melcher, JR
AF Sigalovsky, IS
Melcher, JR
TI Effects of sound level on fMRI activation in human brainstem, thalamic
and cortical centers
SO HEARING RESEARCH
LA English
DT Article
DE BOLD; sound intensity; level coding; cardiac gating; sparse imaging;
interleaved sampling
ID PRIMARY AUDITORY-CORTEX; DEPENDENT REPRESENTATION; TEMPORAL ENVELOPE;
PRESSURE LEVEL; HESCHLS GYRUS; STIMULI; NOISE; CAT; INTENSITY; FREQUENCY
AB The dependence of fMRI activation on sound level was examined throughout the auditory pathway of normal human listeners using continuous broadband noise, a stimulus widely used in neuroscientific investigations of auditory processing, but largely neglected in neuro-imaging. Several specialized techniques were combined here for the first time to enhance detection of brainstem activation, mitigate scanner noise, and recover temporal resolution lost by the mitigation technique. The main finding was increased activation with increasing level in cochlear nucleus, superior olive, inferior colliculus, medial geniculate body and auditory cortical areas. We suggest that these increases reflect monotonically increasing activity in a preponderance of individual auditory neurons responsive to broadband noise. While the time-course of activation changed with level, the change was subtle and only significant in a part of the cortex. To our knowledge, these are the first fMRI data showing the effects of sound level in subcortical centers or for a non-tonal, non-speech stimulus at any stage of the pathway. The present results add to the body of parametric data in normal human listeners and are fundamental to the design of any fMRI experiment employing continuous noise. (c) 2006 Elsevier B.V. All rights reserved.
C1 Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Biosci & Technol Program, Cambridge, MA USA.
Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Sigalovsky, IS (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM plumbum@alum.mit.edu
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NR 40
TC 40
Z9 43
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 67
EP 76
DI 10.1016/j.heares.2006.03.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900008
PM 16644153
ER
PT J
AU Wang, HT
Luo, B
Zhou, KQ
Xu, TL
Chen, L
AF Wang, HT
Luo, B
Zhou, KQ
Xu, TL
Chen, L
TI Sodium salicylate reduces inhibitory postsynaptic currents in-neurons of
rat auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE sodium salicylate; inhibitory postsynaptic current; tinnitus; auditory
cortex; whole-cell patch-clamp; rat; brain slice
ID INFERIOR COLLICULUS; ANIMAL-MODEL; TINNITUS; OTOTOXICITY; PLASTICITY; AI
AB Sodium salicylate (SS) is a medicine for anti-inflammation and for chronic pain relief with a side effect of tinnitus. To understand the cellular mechanisms of tinnitus induced by SS in the central auditory system, we examined effects of SS on evoked and miniature inhibitory postsynaptic currents (eIPSCs and mIPSCs) recorded from layer II/III pyramidal neurons of rat auditory cortex in a brain slice preparation with whole-cell patch-clamp techniques. Both eIPSCs and mIPSCs recorded from the auditory cortex could be completely blocked by bicuculline; a selective GABA(A) receptor antagonist. SS did not change the input resistance of neurons but was found to reversibly depress eIPSCs in a concentration-dependent manner. SS reduced eIPSCs to 82.3% of the control level at 0.5 mM (n = 7) and to 60.9% at 1.4 mM (n = 12). In addition, SS at 1.4 mM significantly reduced the amplitude of mIPSCs from 24.12 +/- 1.44 pA to 19.92 +/- 1.31 pA and reduced the frequency of mIPSCs from 1.34 +/- 0.23 Hz to 0.89 +/- 0.13 Hz (n = 6). Our results demonstrate that SS attenuates inhibitory postsynaptic currents in the auditory cortex, suggesting that the alteration of inhibitory neural circuits may be one of the cellular mechanisms for tinnitus induced by SS in the central auditory region. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Sci & Technol China, Sch Life Sci, Auditory Res Lab, Hefei 230027, Peoples R China.
Univ Sci & Technol China, Sch Life Sci, Lab Receptor Pharmacol, Hefei 230027, Peoples R China.
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China.
RP Chen, L (reprint author), Univ Sci & Technol China, Sch Life Sci, Auditory Res Lab, 443 Yellow Mt Rd, Hefei 230027, Peoples R China.
EM linchen@ustc.edu.cn
RI Chen, Lin/N-8327-2013
OI Chen, Lin/0000-0002-5847-2989
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NR 32
TC 38
Z9 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 77
EP 83
DI 10.1016/j.heares.2006.03.004
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900009
PM 16632286
ER
PT J
AU Kim, Y
Xin, J
Qi, YY
AF Kim, Y
Xin, J
Qi, YY
TI A study of hearing aid gain functions based on a nonlinear nonlocal
feedforward cochlea model
SO HEARING RESEARCH
LA English
DT Article
DE cochlea model; intelligibility; model based amplification; noises;
adaptive amplification
ID AUDIBILITY; MECHANICS
AB A model based sound amplification method is proposed and studied to enhance the ability of the hearing impaired. The model consists of mechanical equations on basilar membrane and outer hair cell (OHC). The OHC is described by a nonlinear nonlocal feedforward model. In addition, a perceptive correction is defined to account for the lumped effect of higher level auditory processing, motivated by the intelligibility function of the hearing impaired. The gain functions are computed by matching the impaired model output to the perceptively weighted normal output, and qualitative agreement is achieved with NAL-NL:1 prescription on clean signals. For noisy signals, an adaptive gain strategy is proposed based on the signal to noise ratios (SNR) computed by the model. The adaptive gain functions provide less gain as SNRs decrease so that the intelligibility can be higher with the adaptivity. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Calif Irvine, Dept Math, Irvine, CA 92697 USA.
Univ Texas, Inst Computat Engn & Sci, Austin, TX 78712 USA.
Qualcomm Inc, San Diego, CA 92121 USA.
RP Xin, J (reprint author), Univ Calif Irvine, Dept Math, Irvine, CA 92697 USA.
EM kimy@ices.utexas.edu; jxin@math.uci.edu
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NR 20
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 84
EP 96
DI 10.1016/j.heares.2006.03.013
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900010
PM 16678986
ER
PT J
AU Anderson, M
Bostrom, M
Pfaller, K
Glueckert, R
Schrott-Fischer, A
Gerdin, B
Rask-Andersen, H
AF Anderson, M
Bostrom, M
Pfaller, K
Glueckert, R
Schrott-Fischer, A
Gerdin, B
Rask-Andersen, H
TI Structure and locomotion of adult in vitro regenerated spiral ganglion
growth cones - A study using video microscopy and SEM
SO HEARING RESEARCH
LA English
DT Article
DE spiral ganglion; growth cone; SEM; TLVM; in vitro
ID NERVE GROWTH; CYTOSKELETAL DYNAMICS; NEUROTROPHIC FACTOR; AUDITORY
NEURONS; CYTOCHALASIN-B; AXON GUIDANCE; INNER-EAR; CELLS; EXPRESSION;
MYOSIN
AB Neuronal development and neurite regeneration depends on the locomotion and navigation of nerve growth cones (GCs). There are few detailed descriptions of the GC function and structure in the adult auditory system. In this study. GCs of adult dissociated and cultured spiral ganglion (SG) neurons were analyzed in vitro utilizing combined high resolution scanning electron microscopy (SEM) and time lapse video microscopy (TLVM). Axon kinesis was assessed on planar substratum with growth factors BDNF, NT-3 and GDNF. At the nano-scale level, lamellipodial abdomen of the expanding GC was found to be decorated with short surface specializations, which at TLVM were considered to be related to their crawling capacity. Filopodia were devoid of these surface structures, supporting its generally described sensory role. Microspikes appearing on lamellipodia and axons, showed circular adhesions, which at TLVM were found to provide anchorage of the navigating and turning axon. Neurons and GCs expressed the DCC-receptor for the guidance molecule netrin-1. Asymmetric ligand-based stimulation initiated turning responses suggest that this attractant cue influences steering of GC in adult regenerating auditory neurites. Hopefully, these findings may be used for ensuing tentative navigation of spiral ganglion neurosis to induce regenerative processes in the human ear. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Uppsala Hosp, Dept Surg Sci, Unit Otosurg, Uppsala, Sweden.
Univ Uppsala Hosp, Dept Surg Sci, Unit Plast Surg, Uppsala, Sweden.
Med Univ Innsbruck, Dept Anat Histol & Embryol, Div Histol & Embryol, Innsbruck, Austria.
Med Univ Innsbruck, Dept Otolaryngol, Innsbruck, Austria.
RP Anderson, M (reprint author), Univ Uppsala Hosp, Dept Surg Sci, Unit Otosurg, Uppsala, Sweden.
EM malin.anderson@gmail.com
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NR 43
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2006
VL 215
IS 1-2
BP 97
EP 107
DI 10.1016/j.heares.2006.03.014
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 052ZX
UT WOS:000238273900011
PM 16684592
ER
PT J
AU Murashita, H
Tabuchi, K
Hoshino, T
Tsuji, S
Hara, A
AF Murashita, H
Tabuchi, K
Hoshino, T
Tsuji, S
Hara, A
TI The effects of tempol, 3-aminobenzamide and nitric oxide synthase
inhibitors on acoustic injury of the mouse cochlea
SO HEARING RESEARCH
LA English
DT Article
DE acoustic injury; cochlea; tempol; poly (ADP-ribose) synthetase (PARS);
nitric oxide synthase
ID TRANSIENT LOCAL ANOXIA; FREE-RADICAL SCAVENGER; POLY(ADP-RIBOSE)
POLYMERASE; SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; GUINEA-PIG;
CELL-DEATH; DYSFUNCTION; TRAUMA; DAMAGE
AB Oxygen free radicals have been implicated in the pathogenesis of acoustic injury of the cochlea. The purpose of this study was to evaluate the effects of tempol (a superoxide anion scavenger), 3-aminobenzamide (a poly (ADP-ribose) synthetase (PARS) inhibitor), N-nitro-(L)-arginine (a non-selective nitric oxide synthase (NOS) inhibitor), 7-nitroindazole (a selective neuronal NOS inhibitor) and aminoguanidine (a selective inducible NOS inhibitor) on acoustic injury. Mice were exposed to a 4 kHz pure tone of 110-128 dB SPL for 4 h. Tempol, 3-amino benzamide or N-nitro-(L)-arginine was intraperitoneally administered immediately before the onset of acoustic overexposure, while 7-nitroindazole or aminoguanidine was intraperitoneally administered every 12 h starting immediately before the onset of acoustic overexposure. The threshold shift of the auditory brainstem response (ABR) and hair cell loss were then evaluated one and two weeks after acoustic overexposure. Tempol and 3-aminobenzamide significantly protected the cochlea against acoustic injury, whereas the NOS inhibitors did not exert any protective effect. These findings suggest that reactive oxygen species and PARS are involved in acoustic injury of the cochlea. However, further study is necessary to elucidate the roles of nitric oxide and nitric oxide synthase in acoustic injury. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Tsukuba, Grad Sch Comprehens Human Sci Majors Funct & Regu, Dept Otolaryngol, Tsukuba, Ibaraki 3058575, Japan.
Tsukuba Univ Hosp, Dept Otolaryngol, Tsukuba, Ibaraki, Japan.
RP Hara, A (reprint author), Univ Tsukuba, Grad Sch Comprehens Human Sci Majors Funct & Regu, Dept Otolaryngol, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
EM haraakir@md.tsukuba.ac.jp
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NR 25
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2006
VL 214
IS 1-2
BP 1
EP 6
DI 10.1016/j.heares.2005.12.008
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 046NI
UT WOS:000237817900001
PM 16516419
ER
PT J
AU Ghanooni, R
Decaestecker, C
Simon, P
Gablus, HJ
Hassid, S
Choufani, G
AF Ghanooni, R
Decaestecker, C
Simon, P
Gablus, HJ
Hassid, S
Choufani, G
TI Characterization of patterns of expression of protein kinase C-alpha,
-delta -eta, -gamma and -zeta and their correlations to p53, galectin-3,
the retinoic acid receptor-beta and the macrophage migration inhibitory
factor (MIF) in human cholesteatomas
SO HEARING RESEARCH
LA English
DT Article
DE cholesteatoma; galectin; MIF; p53; PKC; RAR beta
ID MIDDLE-EAR CHOLESTEATOMA; DIFFERENTIATION; CALCYCLIN; APOPTOSIS;
OVEREXPRESSION; PROLIFERATION; CELLS; GENE; SKIN
AB Cholesteatoma, is a benign disease characterized by the presence of an unrestrained growth and the accumulation of keratin in the middle ear cavity. Due to roles in cell proliferation, apoptosis and differentiation members of the protein kinase C (PKC) family could be involved in disease progression. This study focuses on the expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta in the epithelial tissues of 56 human cholesteatomas and their correlations with those of previously characterized distributions of p53, galectin-3, retinoic acid receptor-beta (RAR beta) and macrophage migration inhibitory factor (MIF). We have previously reported this marker set to be correlated with keratinocyte differentiation in human cholesteatomas. Our present data clearly show that the percentage of PKC-alpha (but not PKC-delta, -gamma, -eta and -zeta)-immunopositive cells in epithelial tissue fro recurrent cholesteatomas was significantly higher than in non-recurrent cases. Correlations between the PKC isoenzymes and the biological markers were non-uniform. PKC-alpha (but not PKC-alpha, -gamma, -eta and -zeta) expression in epithelial cholesteatoma cells correlated significantly and positively with the percentages of p53-immunopositive cells. The patterns of PKC-alpha and -delta expression, but not of PKC-gamma, -eta and -zeta correlated significantly and positively with galectin-3 expression. In addition, the correlation levels between the expression of PKC-alpha and -delta and that of galectin-3 varied depending on the infection and recurrence status. Presence of RARP correlated significantly (and positively) with the expression of PKC-gamma and -zeta and also in relation to the infection and recurrence status. MIF correlated presence significantly (and positively) with that of the five PKCs under study, depending on whether the cholesteatomas were non-infected or infected as well as non-recurrent or recurrent. In conclusion, the present study suggests that modifications occurring at the level of keratinocyte differentiation in human cholesteatomas involve distinct effectors, to which the activation of PKC-alpha, -delta, -eta, -gamma and -zeta can be added.
C1 Erasme Univ Hosp, Dept Otolaryngol, B-1070 Brussels, Belgium.
Erasme Univ Hosp, Dept Head & Neck Surg, B-1070 Brussels, Belgium.
Univ Libre Bruxelles, Fac Med, Lab Histopathol, Brussels, Belgium.
Univ Munich, Inst Physiol Chem, D-8000 Munich, Germany.
RP Ghanooni, R (reprint author), Erasme Univ Hosp, Dept Otolaryngol, 808 Route Lennik, B-1070 Brussels, Belgium.
EM rosemaryam_ghanooni@yahoo.fr
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NR 32
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2006
VL 214
IS 1-2
BP 7
EP 16
DI 10.1016/j.heares.2006.01.013
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 046NI
UT WOS:000237817900002
PM 16513304
ER
PT J
AU Briaire, JJ
Frijns, JHM
AF Briaire, JJ
Frijns, JHM
TI The consequences of neural degeneration regarding optimal cochlear
implant position in scala tympani: A model approach
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; electrode design; eCAP; volume conduction; neural
degeneration
ID ELECTRICALLY STIMULATED COCHLEA; ROTATIONALLY SYMMETRICAL MODEL;
POSTOPERATIVE PERFORMANCE; VOLUME CONDUCTION; SPEECH-PERCEPTION;
ELECTRODE ARRAY; AUDITORY-NERVE; EXCITATION; INTRACOCHLEAR; PREDICTORS
AB Cochlear implant research endeavors to optimize the spatial selectivity, threshold and dynamic range with the objective of improving the speech perception performance of the implant user. One of the ways to achieve some of these goals is by electrode design. New cochlear implant electrode designs strive to bring the electrode contacts into close proximity to the nerve fibers in the modiolus: this is done by placing the contacts on the medial side of the array and positioning the implant against the medial wall of scala tympani. The question remains whether this is the optimal position for a cochlea with intact neural fibers and, if so, whether it is also true for a cochlea with degenerated neural fibers. In this study a computational model of the implanted human cochlea is used to investigate the optimal position of the array with respect to threshold, dynamic range and spatial selectivity for a cochlea with intact nerve fibers and for degenerated nerve fibers. In addition, the model is used to evaluate the predictive value of eCAP measurements for obtaining peri-operative information on the neural status.
The model predicts improved threshold, dynamic range and spatial selectivity for the peri-modiolar position at the basal end of the cochlea, with minimal influence of neural degeneration. At the apical end of the array (1.5 cochlear turns), the dynamic range and the spatial selectivity are limited due to the occurrence of cross-turn stimulation, with the exception of the condition without neural degeneration and with the electrode array along the lateral wall of scala tympani. The eCAP simulations indicate that a large P-0 peak occurs before the N1P1 complex when the fibers are not degenerated. The absence of this peak might be used as an indicator for neural degeneration. (c) 2006 Elsevier B.V. All rights reserved.
C1 Leiden Univ, Med Ctr, ENT Dept, NL-2300 RC Leiden, Netherlands.
RP Briaire, JJ (reprint author), Leiden Univ, Med Ctr, ENT Dept, POB 9600, NL-2300 RC Leiden, Netherlands.
EM J.J.Briaire@LUMC.nl
RI Briaire, Jeroen/A-7972-2008; Frijns, Johan/H-6249-2011
OI Briaire, Jeroen/0000-0003-4302-817X;
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NR 38
TC 38
Z9 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2006
VL 214
IS 1-2
BP 17
EP 27
DI 10.1016/j.heares.2006.01.015
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 046NI
UT WOS:000237817900003
PM 16520009
ER
PT J
AU Kanzaki, S
Beyer, LA
Swiderski, DL
Izumikawa, M
Stover, T
Kawamoto, K
Raphael, Y
AF Kanzaki, S
Beyer, LA
Swiderski, DL
Izumikawa, M
Stover, T
Kawamoto, K
Raphael, Y
TI P27(Kip1) deficiency causes organ of Corti pathology and hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE hair cell; cell cycle; deafness; p27(Kip1); mouse
ID HAIR-CELLS; MICE LACKING; BASILAR PAPILLA; INNER-EAR; PROLIFERATION;
INHIBITOR; GENE; HYPERPLASIA; EXPRESSION; GENERATION
AB p27(Kip1) (p27) has been shown to inhibit several cyclin-dependent kinase molecules and to play a central role in regulating entry into the cell cycle. Once hair cells in the cochlea are formed, p27 is expressed in non-sensory cells of the organ of Corti and prevents their re-entry into the cell cycle. In one line of p27 deficient mice (p27(-/-)), cell division in the organ of Corti continues past its normal embryonic time, leading to continual production of cells in the organ of Corti. Here we report on the structure and function of the inner ear in another line of p27 deficient mice originating from the Memorial Sloan-Kettering Cancer Center. The deficiency in p27 expression of these mice is incomplete, as they retain expression of amino acids 52-197. We determined that mice homozygote for this mutation had severe hearing loss and their organ of Corti exhibited an increase in the number of inner and outer hair cells. There also was a marked increase in the number of supporting cells, with severe pathologies in pillar cells. These data show similarities between this P27(Kip1) mutation and another, previously reported null allele of this gene, and suggest that reducing the inhibition on the cell cycle in the organ of Corti leads to pathology and dysfunction. Manipulations to regulate the time and place of p27 inhibition will be necessary for inducing functionally useful hair cell regeneration. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Sch Med, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Keio Univ, Dept Otolaryngol, Shinjuku Ku, Tokyo 1600016, Japan.
Univ Hannover, Dept Otolaryngol, D-30167 Hannover, Germany.
Kansai Med Univ, Dept Otolaryngol, Osaka, Japan.
RP Raphael, Y (reprint author), Univ Michigan, Sch Med, Kresge Hearing Res Inst, MSRB 3 Room 9303,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM yoash@umich.edu
RI Kanzaki, Sho/B-3100-2014
OI Kanzaki, Sho/0000-0001-9056-0850
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NR 24
TC 25
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2006
VL 214
IS 1-2
BP 28
EP 36
DI 10.1016/j.heares.2006.01.014
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 046NI
UT WOS:000237817900004
PM 16513305
ER
PT J
AU Kanzaki, S
Beyer, L
Karolyi, IJ
Dolan, DF
Fang, Q
Probst, FJ
Camper, SA
Raphael, Y
AF Kanzaki, S
Beyer, L
Karolyi, IJ
Dolan, DF
Fang, Q
Probst, FJ
Camper, SA
Raphael, Y
TI Transgene correction maintains normal cochlear structure and function in
6-month-old Myo15a mutant mice
SO HEARING RESEARCH
LA English
DT Article
DE Shaker2 mouse; cytocaud; phenotypic rescue; BAC transgene
ID INDUCED HEARING-LOSS; HAIR CELL PATHOLOGY; UNCONVENTIONAL MYOSIN;
SHAKER-2 MOUSE; DEAFNESS DFNB3; GENE DOSAGE; GUINEA-PIG; INNER-EAR;
STEREOCILIA; ALLELES
AB The shaker2 (sh2) mouse is a murine model for human non-syndromic deafness DFNB3. The mice have abnormal circling behavior suggesting a balanced disorder, and profound deafness. The insertion of a bacterial artificial chromosome (BAC) transgene containing the Myo15a gene into sh2/sh2 zygotes confers hearing capability and abolishes the circling behavior in 1-month-old transgenic animals. In this study, we investigated both the hearing and the morphology of the cochlea in Myo15a mutants carrying this BAC transgene at two, four, or six months of age. The hearing threshold of these mice is normal, with no physiologically significant differences compared to agematched heterozygous sh2J mice (with or without the BAC transgene). In six-month-old transgenic mice with the BAC, the morphology of hair cells in the apical and upper basal turns of the cochlea is normal. Hair cells of lower basal turn, however, were missing in some mutant animals. This study demonstrates that BAC transgene correction cannot only maintain normal morphology but also confer stable hearing function in Myo15a mutant mice for as long as 6 months. In addition, excess Myo15a expression has no physiologically significant protective or deleterious effects on hearing of normal mice, suggesting that the dosage of Myo15a may not be problematic for gene therapy. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Keio Univ, Dept Otolaryngol, Shinjuku Ku, Tokyo 1600016, Japan.
Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
RP Raphael, Y (reprint author), Univ Michigan, Kresge Hearing Res Inst, MSRB 3 Room 9303, Ann Arbor, MI 48109 USA.
EM yoash@umich.edu
RI Fang, Qing/D-6338-2012; Kanzaki, Sho/B-3100-2014
OI Kanzaki, Sho/0000-0001-9056-0850
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NR 33
TC 7
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2006
VL 214
IS 1-2
BP 37
EP 44
DI 10.1016/j.heares.2006.01.017
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 046NI
UT WOS:000237817900005
PM 16580798
ER
PT J
AU Lu, TK
Zhak, S
Dallos, P
Sarpeshkar, R
AF Lu, Timothy K.
Zhak, Serhii
Dallos, Peter
Sarpeshkar, Rahul
TI Fast cochlear amplification with slow outer hair cells
SO HEARING RESEARCH
LA English
DT Article
DE cochlear amplifier; outer hair cell; receptor potential; membrane time
constant low-pass filtering; electromotility; negative feedback
ID GUINEA-PIG COCHLEA; BASILAR-MEMBRANE; FREQUENCY-RESPONSE; TECTORIAL
MEMBRANE; MAMMALIAN COCHLEA; MECHANOELECTRICAL-TRANSDUCTION; OTOACOUSTIC
EMISSIONS; HYDRODYNAMIC-FORCES; INPUT IMPEDANCE; TRAVELING-WAVE
AB In mammalian cochleas, outer hair cells (OHCs) produce mechanical amplification over the entire audio-frequency range (up to 100 kHz). Under the 'somatic electromotility' theory, mechano-electrical transduction modulates the OHC transmembrane potential, driving an 0HC mechanical response which generates cycle-by-cycle mechanical amplification. Yet, though the OHC motor responds up to at least 70 kHz, the OHC membrane RC time constant (in vitro upper limit similar to 1000 Hz) reduces the potential driving the motor at high frequencies. Thus, the mechanism for high-frequency amplification with slow OHCs has been. a two-decade-long mystery. Previous models fit to experimental data incorporated slow OHCs but did not explain how the OHC time constant limitation is overcome. Our key contribution is showing that negative feedback due to organ-of-Corti functional anatomy with adequate OHC gain significantly extends closed-loop system bandwidth and increases resonant gain. The OHC gain-bandwidth product, not just bandwidth, determines if high-frequency amplification is possible. Due to the cochlea's collective traveling-wave architecture, a single OHC's gain need not be great. OHC piezoelectricity increases the effectiveness of negative-feedback but is not essential for amplification. Thus, emergent closed-loop network dynamics differ significantly from open-loop component dynamics, a generally important principle in complex biological systems. (c) 2006 Elsevier B.V. All rights reserved.
C1 MIT, Analog VLSI & Biol Syst Grp, Res Lab Elect, Cambridge, MA 02139 USA.
Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
Northwestern Univ, Dept Neurobiol & Physiol, Auditory Physiol Lab, Evanston, IL 60208 USA.
Northwestern Univ, Dept Commun Sci & Disorders, Auditory Physiol Lab, Evanston, IL 60208 USA.
RP Sarpeshkar, R (reprint author), MIT, Analog VLSI & Biol Syst Grp, Res Lab Elect, 77 Massachusetts Ave,Room 38-276, Cambridge, MA 02139 USA.
EM rahuls@mit.edu
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NR 91
TC 29
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2006
VL 214
IS 1-2
BP 45
EP 67
DI 10.1016/j.heares.2006.01.018
PG 23
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 046NI
UT WOS:000237817900006
PM 16603325
ER
PT J
AU Frey, A
Lampert, A
Waldegger, S
Jeck, N
Waldegger, P
Artunc, F
Seebohm, G
Lang, UE
Kupka, S
Pfister, M
Hoppe, J
Gerloff, C
Schaeffeler, E
Schwab, M
Lang, F
AF Frey, A
Lampert, A
Waldegger, S
Jeck, N
Waldegger, P
Artunc, F
Seebohm, G
Lang, UE
Kupka, S
Pfister, M
Hoppe, J
Gerloff, C
Schaeffeler, E
Schwab, M
Lang, F
TI Influence of gain of function epithelial chloride channel ClC-Kb
mutation on hearing thresholds
SO HEARING RESEARCH
LA English
DT Article
DE chloride channels; stria vascularis; single nucleotide polymorphism; Cl-
secretion; hearing loss
ID STRIAL MARGINAL CELLS; INNER-EAR; MESSENGER-RNA; GENE PROMOTER;
EXPRESSION; RAT; DEAFNESS; KIDNEY; BARTTIN; COCHLEA
AB Hearing depends on functional ClC-K-type chloride channels composed of barttin with ClC-Ka or ClC-Kb. Loss-of-function mutations of the barttin gene BSND or of both, the ClC-Ka gene CLNKA and the ClC-Kb gene CLNKB lead to congenital deafness and renal salt wasting. Recently, we identified the gain-of-function mutation ClC-Kb(T411S) which is associated with increased blood pressure. To explore the impact of ClC-Kb(T411S) on hearing, healthy volunteers (n = 329) and individuals suffering from tinnitus (n = 246) volunteered for hearing tests (n = 348) and genetic analysis (n = 575). 19.1% of the individuals were heterozygote (ClC-Kb(T41IS)/ClC-Kb) and 1.7% homozygote carriers. Pure tone average hearing threshold (PTAt) for air conduction was significantly (p < 0.033) lower in ClC-Kb(T481S) carriers (13.2 +/- 1.2 dB) than in wild-type individuals (17.1 +/- 0.9 dB). The prevalence of ClC-Kb(T411S) carriers was significantly increased (29.7%) in individuals with PTAt < 15 dB (p < 0.05) and significantly decreased (13.2%) in individuals with PTAt > 30 dB (P < 0.017). The difference was largely due to the female population. Bone conduction was less affected pointing to an effect of the mutation on middle ear function. Tinnitus tended to be more frequent in ClC-Kb(T411S) carriers, a difference, however, not statistically significant. In conclusion, hearing thresholds are slightly lower in carriers of ClC-Kb(T411S), i.e., the gain-of-function polymorphism ClC-Kb(T481S) exerts a subtle but significant protective effect against hearing loss. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Tubingen, Dept Physiol, D-72076 Tubingen, Germany.
Univ Tubingen, Dept Otolaryngol, D-72076 Tubingen, Germany.
Univ Tubingen, Dept Neurol, D-72076 Tubingen, Germany.
Univ Marburg, Dept Pediat, D-35032 Marburg, Germany.
Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-7000 Stuttgart, Germany.
RP Lang, F (reprint author), Univ Tubingen, Dept Physiol, Gmelinstr 5, D-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
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NR 23
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2006
VL 214
IS 1-2
BP 68
EP 75
DI 10.1016/j.heares.2006.02.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 046NI
UT WOS:000237817900007
PM 16549283
ER
PT J
AU PiCClotti, PM
Fetoni, AR
Paludetti, G
Wolf, FI
Torsello, A
Trolani, D
Ferraresi, A
Pola, R
Sergi, B
AF PiCClotti, PM
Fetoni, AR
Paludetti, G
Wolf, FI
Torsello, A
Trolani, D
Ferraresi, A
Pola, R
Sergi, B
TI Vascular endothelial growth factor (VEGF) expression in noise-induced
hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE noise; cochlea; VEGF; VEGF-receptors
ID COCHLEAR BLOOD-FLOW; GUINEA-PIG; IN-VIVO; MOUSE COCHLEA; GENE-TRANSFER;
RECEPTORS; EXPOSURE; CELLS; ANGIOGENESIS; NEUROPATHY
AB Noise-induced hearing loss has been associated with alterations in cochlear blood flow. Our study analyzed the expression of Vascular Endothelial Growth Factor (VEGF) and its functional receptors, Flt-1 and Flk-1, in the cochlear structures of noise-exposed and unexposed guinea pigs. VEGF is a prototypical angiogenic agent, with multiple functions on vascular biology, ranging from vascular permeability to endothelial cell migration, proliferation, differentiation, and survival.
Acoustic trauma was induced by a continuous pure tone of 6 kHz, at 120 dB SPL for 30 min. Auditory function was evaluated by electrocochleographic recordings at 2-20 kHz for 7 days. Noise-induced cochlear morphological changes were studied by immunohistochemistry and scanning electron microscopy. The expression of VEGF and its receptors was examined by immunohistochemistry and western blotting analysis. The hearing threshold shift reached a level of 60 dB SPL on day I after trauma and underwent a partial recovery over time, reaching a value of about 20 dB SPL on day 7. Outer hair cell loss was more prominent in the area located 14-16 min from the apex. Increased cochlear VEGF expression was observed in noise-exposed animals, in particular at the level of stria vascularis, spiral ligament, and spiral ganglion cells. No changes were observed in the expression of VEGF-receptors.
Our data suggest a role for VEGF in the regulation of the vascular network in the inner ear after acoustic trauma and during auditory recovery, with potentially important clinical and therapeutic implications. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Sacred Heart, Sch Med, Inst Otolaryngol, I-00168 Rome, Italy.
Univ Sacred Heart, Sch Med, Dept Internal Med, I-00168 Rome, Italy.
Univ Sacred Heart, Sch Med, Inst Pathol, I-00168 Rome, Italy.
Univ Sacred Heart, Sch Med, Inst Human Physiol, I-00168 Rome, Italy.
RP Sergi, B (reprint author), Univ Sacred Heart, Sch Med, Inst Otolaryngol, Lgo A Gemelli 8, I-00168 Rome, Italy.
EM bruno.sergi@rm.unicatt.it
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NR 33
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2006
VL 214
IS 1-2
BP 76
EP 83
DI 10.1016/j.heares.2006.02.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 046NI
UT WOS:000237817900008
PM 16603326
ER
PT J
AU Polley, DB
Cobos, I
Merzenich, MM
Rubenstein, JLR
AF Polley, DB
Cobos, I
Merzenich, MM
Rubenstein, JLR
TI Severe hearing loss in Dlxl mutant mice
SO HEARING RESEARCH
LA English
DT Article
DE ABR; branchial arch; incus; stapes; mouse; ossicles; development
ID HOMEOBOX GENES; TRANSCRIPTIONAL REGULATION; BRANCHIAL ARCHES;
EXPRESSION; DIFFERENTIATION; SKELETAL; LACKING
AB The Dlx homeobox gene family participates in regulating middle and inner ear development. A significant role for Dlx1, in particular, has been demonstrated in the development of the middle ear ossicles, but the functional consequences of Dlx1 gene mutation on hearing thresholds has not been assessed. The present study characterizes auditory brainstem responses to click and tonal stimuli in a non-lethal variant of a Dlx1 gene knockout. We found that peripheral hearing thresholds for click and tonal stimuli were significantly elevated in homozygous Dlx1 knockout (Dlx1(-/-)) compared to both heterozygous (Dlx1(-/-)) and wild type (Dlx1(+/+)) mice. Thus, abnormal morphogenesis of the incus and stapes that has been documented previously with histological measures is now known to result in a severe peripheral hearing deficit. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94158 USA.
Univ Calif San Francisco, Dept Otolaryngol, WM Keck Fdn Ctr Integrat Neurosci, Coleman Mem Lab, San Francisco, CA 94143 USA.
RP Rubenstein, JLR (reprint author), Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94158 USA.
EM daniel.polley@vanderbilt.edu; john.rubenstein@ucsf.edu
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NR 17
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2006
VL 214
IS 1-2
BP 84
EP 88
DI 10.1016/j.heares.2006.02.008
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 046NI
UT WOS:000237817900009
PM 16632068
ER
PT J
AU Hernandez, PP
Moreno, V
Olivari, FA
Allende, ML
AF Hernandez, PP
Moreno, V
Olivari, FA
Allende, ML
TI Sub-lethal concentrations of waterborne copper are toxic to lateral line
neuromasts in zebrafish (Danio rerio)
SO HEARING RESEARCH
LA English
DT Article
DE zebrafish; lateral line; mechanosensory cells; copper toxicity; hair
cell regeneration
ID HAIR CELL-DEATH; POSTEMBRYONIC DEVELOPMENT; EMBRYONIC-DEVELOPMENT;
TRANSPORTER CTR1; FM1-43; EXPOSURE; SYSTEM; FISH; CURRENTS; MUTANTS
AB in teleosts. the lateral line system is composed of neuromasts containing hair cells that are analogous to those present in the inner ear of all vertebrates. In the zebrafish embryo and early larva, this system is composed of the anterior lateral line (ALL). which covers the head, and the posterior lateral line (PLL), present in the trunk and tail. The mechanosensory hair cells found in neuromasts can be labeled in Vivo using fluorescent dyes such as 4-di-2-Asp (DiAsp) or FM 1-43. We have studied the effects of water-borne copper exposure on the function of the lateral line system in zebrafish larvae. our results show that transient incubation of post-hatching larvae for 2 h with non-lethal concentrations of copper (1-50 mu M CuSO4) induces cellular damage localized to neuromasts, apoptosis, and loss of hair cell markers. This effect is specific to copper, as other metals did not show these effects. Since hair cells in fish can regenerate, we followed the reappearance of viable hair cells in neuromasts after copper removal. In the PLL, we determined that there is a threshold concentration of copper above which regeneration does not occur, whereas, at lower concentrations, the length of time it takes for viable hair cells to reappear is dependent oil the amount of copper used during the treatment. The ALL behaves differently though, as regeneration can Occur even after treatments with concentrations of copper an order of magnitude higher than the one that irreversibly affects the PLL. Regeneration of hair cells is dependent oil cell division within the neuromasts as damage that precludes proliferation prevents reappearance of this cell type. (C) 2005 Published by Elsevier B.V.
C1 Univ Chile, Fac Ciencias, Millennium Nucleus Dev Biol, Santiago, Chile.
Univ Chile, Fac Ciencias, Dept Biol, Santiago, Chile.
RP Allende, ML (reprint author), Univ Chile, Fac Ciencias, Millennium Nucleus Dev Biol, Encinas 3370,Edificio Milenio,Casilla 653, Santiago, Chile.
EM allende@uchile.cl
RI Allende, Miguel/C-5167-2008
OI Allende, Miguel/0000-0002-2783-2152
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NR 45
TC 59
Z9 61
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 1
EP 10
DI 10.1016/j.heares.2005.10.015
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400001
PM 16386394
ER
PT J
AU Ohashi, M
Ide, S
Kimitsuki, T
Komune, S
Suganuma, T
AF Ohashi, M
Ide, S
Kimitsuki, T
Komune, S
Suganuma, T
TI Three-dimensional regular arrangement of the annular ligament of the rat
stapediovestibular joint
SO HEARING RESEARCH
LA English
DT Article
DE annular ligament; stapediovestibular joint; electron microscopy; elastic
fiber; rat
ID ELECTRON MICROSCOPY; OTOSCLEROSIS; STAIN
AB The stapes footplate articulates with the vestibular window through the annular ligament. This articulation is known as the stapediovestibular joint (SVJ). We investigated the ultrastructure of adult rat SVJ and report here on the characteristic ultrastructure of the corresponding annular ligament. Transmission electron microscopy showed that this annular ligament comprises thick ligament fibers consisting of a peripheral mantle of microfibrils and an electron-lucent central amorphous Substance that is regularly arranged in a linear fashion, forming laminated structures parallel to the horizontal plane of the SVJ. Scanning electron microscopy revealed that transverse microfibrils cross the thick ligament fibers, showing a lattice-like structure. The annular ligament was vividly stained with elastica van Gieson's stain and the Verhoeffs iron hematoxylin method. Staining of the electron-lucent central amorphous substance of the thick ligament fibers by the tannate-metal salt method revealed in intense electron density. These results indicate that the annular ligament of the SVJ is mainly composed of mature elastic fibers. (C) 2005 Elsevier B.V. All rights reserved.
C1 Miyazaki Univ, Fac Med, Dept Anat, Miyazaki 8891692, Japan.
Kyushu Univ, Fac Med, Dept Otolaryngol, Fukuoka 8128582, Japan.
RP Suganuma, T (reprint author), Miyazaki Univ, Fac Med, Dept Anat, 5200 Kihara, Miyazaki 8891692, Japan.
EM suganumat@med.miyazaki-u.ac.jp
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NR 24
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 11
EP 16
DI 10.1016/j.heares.2005.11.007
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400002
PM 16476532
ER
PT J
AU Hullar, TE
Williams, CD
AF Hullar, TE
Williams, CD
TI Geometry of the semicircular canals of the chinchilla (Chinchilla
laniger)
SO HEARING RESEARCH
LA English
DT Article
DE vestibular; vestibulo-ocular reflex; anatomy; afferent; prime direction;
chinchilla
ID AIDED 3-DIMENSIONAL RECONSTRUCTION; PLANAR RELATIONSHIPS; PHYSIOLOGIC
CHARACTERISTICS; VESTIBULAR AFFERENTS; DIMENSIONAL ANALYSIS; GUINEA-PIG;
ORIENTATION; CAT; MORPHOLOGY; RESPONSES
AB The orientations of the semicircular canals determines the response of the canals to head rotations and, in turn, the brain's ability to interpret those motions. The geometry of chinchillas' semicircular canals has never been reported.
Volumetric representations of three chinchilla skulls were generated using a microCT scanner. The centroids of each semicircular canal lumen were identified its they passed through the image slices and were regressed to a plane. Unit vectors normal to the plane representing canal orientations were used to calculate angles between canal pairs. Pitch and roll maneuvers required to bring any canal into the horizontal plane for physiologic investigation were calculated.
The semicircular canals of the chinchilla were found to be relatively planar. The horizontal canal was found to be oriented 55.0 degrees anteriorly upward. Pairs of ipsilateral chinchilla canals were not orthogonal and contralateral synergistic pairs were not parallel. Despite this arrangement, the canal plane unit normal vectors were organized to respond with approximately equal overall sensitivity to rotations in any direction. The non-orthogonal chinchilla labyrinth may provide all opportunity to determine whether the frame of reference used by the central vestibular and oculomotor system is based oil directions of afferent maximum sensitivity or prime directions. (C) 2005 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA.
RP Hullar, TE (reprint author), Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 S Euclid Ave 8115, St Louis, MO 63110 USA.
EM hullart@ent.wustl.edu
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NR 43
TC 21
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 17
EP 24
DI 10.1016/j.heares.2005.11.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400003
PM 16439079
ER
PT J
AU Santos, F
MacDonald, G
Rubel, EW
Raible, DW
AF Santos, F
MacDonald, G
Rubel, EW
Raible, DW
TI Lateral line hair cell maturation is a determinant of aminoglycoside
susceptibility in zebrafish (Danio rerio)
SO HEARING RESEARCH
LA English
DT Article
DE ototoxicity; aminoglycosides; mechanotransduction; hearing loss
ID IN-VITRO; GUINEA-PIG; GENTAMICIN EXPOSURE; CASPASE ACTIVATION; BASILAR
PAPILLA; FREE-RADICALS; MYOSIN VIIA; DEATH; NEOMYCIN; OTOTOXICITY
AB Developmental differences in hair cell susceptibility to aminoglycoside-induced cell death has been observed in multiple species. Increased sensitivity to aminoglycosides has been temporally correlated with the onset of mechanotransduction dependent activity. We have used in vivo fluorescent vital dye markers to further investigate the determinants of aminoglycoside induced hair cell death in the lateral line of zebrafish (Danio rerio). Labeling hair cells of the lateral line in vivo with the dyes FM 1-43, To-Pro-3, and Yo-Pro-1 served as reliable indicators of hair cell viability. Results indicate that hair cell maturation is a determinant of developmental differences in Susceptibility. The age dependent differences in susceptibility to aminoglycosides are independent of the onset of mechanotransduction-dependent activity as measured by FM 1-43 uptake and independent of hair cell ability to take Lip fluorescently Conjugated aminoglycosides. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA.
RP Rubel, EW (reprint author), Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Box 357923, Seattle, WA 98195 USA.
EM rubel@u.washington.edu; draible@u.washington.edu
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NR 64
TC 58
Z9 60
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 25
EP 33
DI 10.1016/j.heares.2005.12.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400004
PM 16459035
ER
PT J
AU Baumann, U
Nobbe, A
AF Baumann, U
Nobbe, A
TI The cochlear implant electrode-pitch function
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; electric hearing; frequency-place function; pitch
sensation
ID SPEECH-PERCEPTION; DEAD REGIONS; INSERTION; HEARING; ARRAYS; NEURON;
MODEL
AB The cochlear frequency-place function in normal hearing cars has been found to be an exponential relationship in a wide variety of species [D.D. Greenwood, J. Acoust. Soc. Am. 87 (1990) 2592-2605]. Although it seems reasonable to assume a similar function for electrical stimulation by means of an intra-cochlear electrode array, the exact frequency-place function for this special type of stimulation needs to be investigated. Six users of the MED-EL COMBI 40+ cochlear implant device with moderate to profound hearing loss between 125 and 1000 Hz in the non-implanted ear took part in a binaural pitch adjustment experiment. The COMBI 40+ electrode array provides a deep insertion into the scala tympani and a wide spatial separation between the stimulating electrodes. Insertion depth was controlled by Stenver's view plain radiographs and the insertion angle was estimated. The task of the subjects was to adjust the frequency of a sinusoid presented in the non-implanted ear by means of an adjusting knob until they perceived the same pitch as was elicited by a reference stimulus in the implanted ear. The results show adjustments corresponding to electrode positions along the cochlea, with the exception of the two most apical electrodes for most of the Subjects. Pitch increased in an orderly fashion with an average of 98 Hz per electrode separation (40 Hz/mm). In contrast to the exponential predictions according to [D.D. Greenwood, J. Acoust. Soc. Am. 87 (1990) 2592-2605] for normal hearing, the average electrode-pitch function shows a linear relationship. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Munich, Dept Otorhinolaryngol, D-81377 Munich, Germany.
Med El GmbH, A-6020 Innsbruck, Austria.
Univ Munich, ENT Dept, Munich, Germany.
RP Baumann, U (reprint author), Univ Munich, Dept Otorhinolaryngol, Marchioninistr 15, D-81377 Munich, Germany.
EM Uwe.Baumann@med.uni-muenchen.de
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NR 20
TC 37
Z9 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 34
EP 42
DI 10.1016/j.heares.2005.12.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400005
PM 16442249
ER
PT J
AU Murao, MS
Bento, RF
Sanchez, TG
Ribas, GC
AF Murao, MS
Bento, RF
Sanchez, TG
Ribas, GC
TI Transient evoked otoacoustic emissions after vestibular nerve section in
chinchillas
SO HEARING RESEARCH
LA English
DT Article
DE olivocochlear bundle; otoacoustic emissions; chinchilla; vestibular
nerve section; outer hair cells
ID OLIVOCOCHLEAR BUNDLE SECTION; SUPERIOR OLIVARY COMPLEX; DISTORTION
PRODUCTS; NEURONS; HUMANS; REFLEX
AB Transient evoked otoacoustic emissions are believed to be sensitive to the effects of the cochlear efferent system. The most well-known function of this system is inhibitory oil cochlear response. It has been demonstrated that crossed medial efferent system section produces inhibitory control of the outer hair cells mechanisms responsible For non-linear transient evoked otoacoustic emissions generation. However, We Suppose that the uncrossed medial efferent system plays a role in outer hair cell function too. We recorded the non-linear part or transient evoked otoacoustic emissions in 17 chinchillas before and after section of the vestibular nerve (crossed and uncrossed fibers). Responses at Frequencies bands centered on 0.8, 1.6, 2.4, 3.2 and 4.0 kHz, as well as total emission responses, were analyzed. After vestibular nerve section, there Were significant increases in the amplitudes of the 2.4- and 4.0 kHz responses and of the total response. These results indicate that the medial efferent system is important to maintain normal cochlear mechanics. Uncrossed medial efferent system and lateral efferent system seem to be not important in maintaining normal cochlear mechanics. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Sao Paulo, Sch Med, Otorhinolaryngol Sci Lab, BR-01246903 Sao Paulo, Brazil.
Univ Sao Paulo, Sch Med, Dept Anat, BR-01246903 Sao Paulo, Brazil.
RP Murao, MS (reprint author), Rua Dona Cota,177,Sala 202, BR-37010560 Varginha, MG, Brazil.
EM marciamurao@hotmail.com
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NR 16
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 43
EP 48
DI 10.1016/j.heares.2005.12.013
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400006
PM 16497453
ER
PT J
AU Gabriel, D
Veuillet, E
Vesson, JF
Collet, L
AF Gabriel, D
Veuillet, E
Vesson, JF
Collet, L
TI Rehabilitation plasticity: Influence of hearing aid fitting on frequency
discrimination performance near the hearing-loss cut-off
SO HEARING RESEARCH
LA English
DT Article
DE frequency discrimination; rehabilitation plasticity; hearing loss;
hearing aid
ID CENTRAL AUDITORY PLASTICITY; CORTICAL REORGANIZATION; UNILATERAL
DEAFNESS; SOMATOSENSORY CORTEX; COCHLEAR LESIONS; MOTOR CORTEX; ORGAN
DAMAGE; LATE-ONSET; MONKEYS; DEAFFERENTATION
AB Several studies have already demonstrated that patients with steeply sloping hearing loss of cochlear origin exhibit an improvement in frequency discrimination performance at or around the cut-off frequency. This enhancement cannot be explained in terms of peripheral mechanisms and should rather be interpreted in terms of central reorganization: i.e., injury-induced cortical plasticity. However, the reversibility and time course of such reorganization has not yet been described. The main goal of the present study was therefore to investigate the occurrence of rehabilitation plasticity associated with hearing-aid fitting in human Subjects. Nine Subjects with steeply sloping hearing loss and who were candidates for auditory rehabilitation were tested. Discrimination-limen-for-frequency (DLF) enhancement was investigated at the frequency With the best DLF (bDLF) For each individual Subject before and during auditory rehabilitation (at 1 month, 3 months and 6 months). From 1 month on, frequency discrimination performance decreased significantly at the bDLF frequency, while remaining stable at other frequencies. This normalization may reflect a new central reorganization reversing the initial injury-induced changes in the cortical map. A correlation between subject's age and alteration in DLF at 1 month was also found, suggesting that plasticity operates faster in younger patients. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Lyon 1, CNRS GDR Protheses Audit 2213, Lab Neurosci & Syst Sensoriels, Unite CNRS UMR 5020, F-69366 Lyon 07, France.
RP Gabriel, D (reprint author), Univ Lyon 1, CNRS GDR Protheses Audit 2213, Lab Neurosci & Syst Sensoriels, Unite CNRS UMR 5020, 50 Av Tony Garnier, F-69366 Lyon 07, France.
EM damiengabriel@yahoo.fr
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NR 31
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 49
EP 57
DI 10.1016/j.heares.2005.12.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400007
PM 16459036
ER
PT J
AU Rajan, R
AF Rajan, R
TI Contextual modulation of cochlear hearing desensitization depends on the
type of loud sound trauma
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; hearing damage; loud sounds; background noise; auditory
ID BASILAR-MEMBRANE VIBRATIONS; TEMPORARY THRESHOLD SHIFT; ACOUSTIC
STIMULATION; MAMMALIAN COCHLEA; MECHANICS; PATHWAYS; INTERFERENCE;
TRANSDUCTION; PATTERNS; DAMAGE
AB In ears in which cochlear efferent pathways were cut and with testing done Under anaesthetic conditions that preclude middle ear muscle activity (so as to examine the "intrinsic" effects of loud sound on the cochlea without any confounding effect of efferent pathways to the auditory periphery), atraumatic background white noise (WN) increases cochlear hearing loss (temporary threshold shifts, TTSs) induced by a traumatic pure tone but reduces TTSs caused by traumatic 5-kHz wide narrow band (NB) sound. The short-duration moderately intense traumata used in these Studies most likely cause TTSs by affecting cochlear mechanics and these WN modulatory effects, exerted directly on the cochlea's intrinsic susceptibility to TTSs, are not predicted by any Current description of cochlear mechanics. Here it is demonstrated that background WN reduces trauma-induced TTSs with even a relatively small increase in trauma bandwidth beyond that of a pure tone, discounting the alternative that contextual modulatory effects transition systematically along a continuum as trauma bandwidth increases from a pure tone to a broader bandwidth (albeit 2 kHz-wide NB) trauma. These results have implications for cochlear mechanics as the TTSs due to the traumatic Sound of this study are most likely due to changes in cochlear mechanics but are not easily explained by what is currently known of cochlear mechanics. (C) 2006 Elsevier B.V. All rights reserved.
C1 Monash Univ, Dept Physiol, Monash, Vic 3800, Australia.
RP Rajan, R (reprint author), Monash Univ, Dept Physiol, Wellington Rd, Monash, Vic 3800, Australia.
EM ramesh.rajan@med.monash.edu.au
RI Rajan, Ramesh/A-5945-2008
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NR 29
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 58
EP 63
DI 10.1016/j.heares.2005.12.006
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400008
PM 16439080
ER
PT J
AU Dai, CF
Mangiardi, D
Cotanche, DA
Steyger, PS
AF Dai, CF
Mangiardi, D
Cotanche, DA
Steyger, PS
TI Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo
SO HEARING RESEARCH
LA English
DT Article
DE inner ear; gentamicin; hair cells; blood-labyrinth barrier
ID COCHLEAR HAIR-CELLS; INNER-EAR TISSUES; AMINOGLYCOSIDE ANTIBIOTICS;
ETHACRYNIC-ACID; GUINEA-PIG; STRIA VASCULARIS; CATION CHANNEL;
HORSERADISH-PEROXIDASE; LLC-PK1 CELLS; GOLGI-COMPLEX
AB Aminoglycoside uptake in the inner ear remains poorly understood. We subcutaneously injected a fluorescently-conjugated aminoglycoside, gentamicin-Texas Red (GTTR), to investigate the in vivo uptake of GTTR in the inner ear of several vertebrates, and in various murine sensory cells using confocal microscopy.
In bullfrogs, GTTR uptake was prominent in mature hair cells, but not in immature hair cells. Avian hair cells accrued GTTR more rapidly at the base of the basilar papilla. GTTR was associated with the hair bundle; and, in guinea pigs and mice, somatic GTTR fluorescence was initially diffuse before punctate (endosomal) fluorescence could be observed. A baso-apical gradient of intracellular GTTR uptake in guinea pig cochleae could only be detected at early time points (<3 h). In 21-28 day mice, cochlear GTTR uptake was greatly reduced compared to guinea pigs, 6-day-old mice, or mice treated with ethacrynic acid. In mice, GTTR was also rapidly taken up, and retained, in the kidney, dorsal root and trigeminal ganglia. In linguinal and vibrissal tissues rapid GTTR uptake cleared over a period of several days.
The preferential uptake of GTTR by mature saccular, and proximal hair cells resembles the pattern of aminoglycoside-induced hair cell death in bullfrogs and chicks. Differences in the degree of GTTR uptake in hair cells of different species suggests variation in serum levels, clearance rates from serum, and/or the developmental and functional integrity of the blood-labyrinth barrier. GTTR uptake by hair cells in vivo suggests that GTTR has potential to elucidate aminoglycoside transport mechanisms into the inner ear, and as a biotracer for in vivo pharmacokinctic studies. (C) 2006 Elsevier B.V. All rights reserved.
C1 Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
Fudan Univ, Eye Ear Nose & Throat Hosp, Dept Otolaryngol, Shanghai 200031, Peoples R China.
Childrens Hosp, Dept Otolaryngol, Boston, MA 02115 USA.
Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.
RP Steyger, PS (reprint author), Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM steygerp@ohsu.edu
RI dai, chenkai/A-8051-2010
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NR 88
TC 44
Z9 47
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 64
EP 78
DI 10.1016/j.heares.2005.11.011
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400009
PM 16466873
ER
PT J
AU Qu, CY
Liang, FH
Hu, W
Shen, ZJ
Spicer, SS
Schulte, BA
AF Qu, CY
Liang, FH
Hu, W
Shen, ZJ
Spicer, SS
Schulte, BA
TI Expression of CLC-K chloride channels in the rat cochlea
SO HEARING RESEARCH
LA English
DT Article
DE chloride channel; ClC-K1; ClC-K2; cochlea; organ of Corti; stria
vascularis; spiral ligament
ID STRIA-VASCULARIS; MARGINAL CELLS; GERBIL COCHLEA; SPIRAL GANGLION;
MESSENGER-RNA; MICE LACKING; INNER-EAR; KIDNEY; LOCALIZATION; ACID
AB Current models of the lateral K+ recycling pathway in the mammalian cochlea include two multicellular transport networks separated from one another by three interstitial gaps. The first gap is between outer hair cells and Deiters cells, the second is between outer sulcus cells and type II spiral ligament fibrocytes and the third is between intermediate and marginal cells in the stria vascularis. K+ taken up by cells bordering these interstitial spaces is accompanied by Cl-. Maintaining appropriate electrolyte balance and membrane potentials in these cells requires a mechanism for exit of the resorbed Cl-. One possible candidate For regulating this Cl- efflux is ClC-K, a chloride channel previously thought to be kidney specific. Here, we demonstrate the expression of both known isoforms of ClC-K in the organ of Corti, spiral ligament and stria vascularis of the rat cochlea by immunohistochemical, Western blot and RT-PCR analysis. These results indicate a role for ClC-K in mediating Cl- recycling in the cochlea. The widespread expression of both ClC-K. isoforms in the cochlea may help to explain the symptoms of Bartter's syndrome Type III, a mutation in the hClC-Kb gene (human homologue of ClC-K2), which results in renal salt wasting without deafness. These data support the hypothesis that both isoforms of ClC-K are co-expressed in sonic cell membranes and account for the preservation of hearing in the presence of a mutation in only one channel isoform. (C) 2006 Elsevier B.V. All rights reserved.
C1 Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA.
Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
RP Schulte, BA (reprint author), Med Univ S Carolina, Dept Pathol & Lab Med, 165 Ashley Ave,Suite 309,POB 250908, Charleston, SC 29425 USA.
EM quc@musc.edu; schulteb@musc.edu
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NR 49
TC 12
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 79
EP 87
DI 10.1016/j.heares.2005.12.012
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400010
PM 16466872
ER
PT J
AU Seither-Preisler, A
Patterson, R
Krumbholz, K
Seither, S
Lutkenhoner, B
AF Seither-Preisler, A
Patterson, R
Krumbholz, K
Seither, S
Lutkenhoner, B
TI Evidence of pitch processing in the N100m component of the auditory
evoked field
SO HEARING RESEARCH
LA English
DT Article
DE N100m latency; AEF; pitch; relative phase; AIM
ID NEUROMAGNETIC EVIDENCE; COMPLEX TONES; FUNCTIONAL-ORGANIZATION; TEMPORAL
INTEGRATION; STIMULUS FREQUENCY; MAGNETIC-FIELDS; SENSORY MEMORY;
VIRTUAL PITCH; HUMAN BRAIN; LATENCY
AB The latency of the N100m component of the auditory evoked field (AEF) is sensitive to the period and spectrum of a sound. However, little attention was paid so fair to the wave shape at stimulus onset, which might have biased previous results. This problem was fixed in the present study by aligning the first major peaks in the acoustic waveforms. The stimuli were harmonic tones (spectral range: 800-5000 Hz) with periods corresponding to 100, 200, 400, and 800 Hz. The frequency components were in sine, alternating or random phase. Simulations with a computational model suggest that the auditory-nerve activity is strongly affected by both the period and the relative phase of the stimulus, whereas the output of the more central pitch processor only depends on the period. Our AEF data, recorded from the right hemisphere of seven subjects, are consistent with the latter prediction: The latency of the N100m depends on the period, but not on the relative phase of the stimulus components. This suggests that the N100m reflects temporal pitch extraction, not necessarily implying that the underlying generators are directly involved in this analysis. (C) 2006 Elsevier B.V. All rights reserved.
C1 Munster Univ Hosp, ENT Clin, Dept Expt Audiol, D-48129 Munster, Germany.
Univ Cambridge, Dept Physiol, Ctr Neural Basis Hearing, Cambridge CB2 3EG, England.
MRC, Inst Hearing Res, Nottingham NG7 2RD, England.
RP Seither-Preisler, A (reprint author), Munster Univ Hosp, ENT Clin, Dept Expt Audiol, Kardinal von Galen Ring 10, D-48129 Munster, Germany.
EM preisler@uni-muenster.de; roy.patterson@mrc-cbu.cam.ac.uk;
katrin@ihr.mrc.ac.uk
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NR 50
TC 19
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 88
EP 98
DI 10.1016/j.heares.2006.01.003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400011
PM 16464550
ER
PT J
AU Lewald, J
Getzmann, S
AF Lewald, J
Getzmann, S
TI Horizontal and vertical effects of eye-position on sound localization
SO HEARING RESEARCH
LA English
DT Article
DE spatial hearing; gaze direction; binaural cues; pinna cues; azimuth;
elevation
ID PRIMATE SUPERIOR COLLICULUS; MINIMUM AUDIBLE ANGLE; AUDITORY
LOCALIZATION; SPATIAL HEARING; INFERIOR COLLICULUS; VISUAL LOCALIZATION;
NECK MUSCLES; MOVEMENTS; DIRECTION; SPACE
AB The effect of gaze direction on the localization of sound sources was investigated in the azimuthal and elevational dimension using a pointing task. In both dimensions, eccentric eye-position induced a significant shift in sound localization that was opposite to the direction of eccentricity. This finding is in accordance with the view that the azimuthal and elevational components of the auditory spatial information are processed in common neural Substrates. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Dortmund, Inst Occupat Physiol, Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany.
Ruhr Univ Bochum, Fac Psychol, Dept Cognit & Environm Psychol, D-44780 Bochum, Germany.
RP Lewald, J (reprint author), Univ Dortmund, Inst Occupat Physiol, Leibniz Res Ctr Working Environm & Human Factors, Ardeystr 67, D-44139 Dortmund, Germany.
EM joerg.lewald@rub.de
RI Lewald, Jorg/D-3034-2009
OI Lewald, Jorg/0000-0001-9351-0170
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NR 42
TC 23
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 99
EP 106
DI 10.1016/j.heares.2006.01.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400012
PM 16466875
ER
PT J
AU Anderson, SE
Kilgard, MP
Sloan, AM
Rennaker, RL
AF Anderson, SE
Kilgard, MP
Sloan, AM
Rennaker, RL
TI Response to broadband repetitive stimuli in auditory cortex of the
unanesthetized rat
SO HEARING RESEARCH
LA English
DT Article
DE unanesthetized; multi-unit; temporal coding; chronic implant
ID FREQUENCY; CAT; ORGANIZATION; MECHANISMS; AMPLITUDE; CLICKS; SOUND
AB This study examines the ability of multi-unit clusters (MUCs) in layer IV/V of primary auditory cortex of the awake rat to respond to a series of broadband click trains. The data from 113 multi-unit clusters were analyzed for synchronous and nonsynchronized responses using several methods. Synchronous responses were measured using window analysis, circular statistics and spectral analysis. Nonsynchronous responses were measured during different time intervals during the click train (first 50 ms, 50-450 ins, and the entire click train). The results demonstrate that multi-unit clusters are capable of synchronizing to clicks at rates up to 166 Hz. The mean synchronization boundary (limiting rate) for the group was found to be 72 Hz. Mean peak response rate, mean response duration, and mean time-to-peak response decreased as the stimulus presentation rate (SPR) increased, resulting in a temporal sharpening of the population response. For fast SPRs (>50 Hz), 50%, of MUCs exhibited nonsynchronous responses in which the firing rate increased with SPR, although this activity was most prevalent during the first 50 ins of the response. Sustained increases in firing rate with SPR were seen in 8%, of he MUCs, while another 38% of MUCs exhibited sustained decreases during the click train. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Oklahoma, Dept Aerosp & Mech Engn, Norman, OK 73019 USA.
Univ Oklahoma, Ctr Bioengn, Sarkeys Engn Ctr T335, Norman, OK 73019 USA.
Univ Texas, Cognit & Neurosci Program, Sch Behav & Brain Sci, Richardson, TX 75083 USA.
RP Rennaker, RL (reprint author), Univ Oklahoma, Dept Aerosp & Mech Engn, 865 Asp Ave Felgar Hall 210, Norman, OK 73019 USA.
EM Rennaker@ou.edu
RI Rennaker, Robert/K-9049-2013
OI Rennaker, Robert/0000-0003-1260-1973
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NR 26
TC 23
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 107
EP 117
DI 10.1016/j.heares.2005.12.011
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400013
PM 16466874
ER
PT J
AU Harris, KC
Bielefeld, E
Hu, BH
Henderson, D
AF Harris, KC
Bielefeld, E
Hu, BH
Henderson, D
TI Increased resistance to free radical damage induced by low-level sound
conditioning
SO HEARING RESEARCH
LA English
DT Article
DE conditioning; paraquat; chinchilla
ID INDUCED HEARING-LOSS; SUPEROXIDE-DISMUTASE; TRAUMATIC EXPOSURE;
THRESHOLD SHIFTS; ACOUSTIC TRAUMA; NOISE EXPOSURE; PROTECTION;
CHINCHILLA; COCHLEA; HYDROETHIDINE
AB Conditioning is the phenomenon where exposure to moderate-level acoustic stimuli can increase the ear's resistance to subsequent more intense sound exposures. In recent years, research has shown that conditioning increases the availability of antioxidant enzymes which presumably protects the ear from oxidative stress induced by a traumatic noise exposure [Jacono, A.A., Hu, B., Kopke, R.D., Henderson, D., Van De Water, T.R., Steinman, H.M., 1998. Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res 117. 31-8]. The current Study was designed to assess whether the increase in endogenous antioxidants seen following conditioning could provide protection from oxidative stress induced by Paraquat, a potent generator of superoxide. Chinchillas were exposed to a conditioning noise, 500 Hz OBN at 95 dB for 6 h/day for 10 days, followed 5 days later with Paraquat application to the round window. Controls underwent the Paraquat application surgery, without prior conditioning. Evoked potential thresholds were determined prior to conditioning, at day 1, 5 and 10 during conditioning, at day 15 (5 days after conditioning), and at day 17, 19, 23, and 35 (1, 3, 7, and 20 days post-Paraquat). The conditioned animals showed reductions in permanent threshold shift and reduced inner hair cell loss relative to controls. These results reinforce the hypothesis that antioxidants are primary mediators of the conditioning effect. (C) 2006 Elsevier B.V. All rights reserved.
C1 Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Harris, KC (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,POB 250550, Charleston, SC 29425 USA.
EM harriskc@musc.edu
RI Bielefeld, Eric/D-2015-2012
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NR 29
TC 10
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 118
EP 129
DI 10.1016/j.heares.2005.11.012
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400014
PM 16466871
ER
PT J
AU Loebach, JL
Wickesberg, RE
AF Loebach, JL
Wickesberg, RE
TI The representation of noise vocoded speech in the auditory nerve of the
chinchilla: Physiological correlates of the perception of spectrally
reduced speech
SO HEARING RESEARCH
LA English
DT Article
DE speech; auditory nerve; spectrally reduced speech; noise vocoded speech
ID NORMAL-HEARING LISTENERS; COCHLEAR IMPLANT USERS; STEADY-STATE VOWELS;
TEMPORAL CUES; CONSONANT RECOGNITION; DISCHARGE PATTERNS; SIGNAL
PROCESSORS; ENVELOPE CUES; SINE-WAVE; CHANNELS
AB This Study investigated the neural representation of naturally produced and noise vocoded speech signals in the auditory nerve of the chinchilla. The syllables /b(sic)/, /d(sic)/, /tu / and /p(sic)/ produced by male speakers were used to synthesize noise vocoded speech stimuli containing one, two, three and four bands of envelope modulated noise. The ensemble response of the auditory nerve, computed by pooling the PST histograms across many auditory nerve fibers, revealed temporal patterns in the responses to the natural tokens that uniquely identified the stop consonants. The responses to the 3- and 4-band noise vocoded tokens contained temporal patterns that were nearly identical to those observed for the natural tokens, while the responses to the 1- and 2-band tokens were significantly different (p < 0.0001). The ALSR, ALIR and autocorrelation of the pooled PST histograms represented the detail of the frequency spectrum for a naturally produced vowel, while the driven rate was unreliable. Each of these spectral analyses failed to reveal significant information about the noise vocoded vowels. These results Suggest that temporal patterns in the responses of the auditory nerve can provide the cues necessary for the recognition of noise vocoded stop consonants. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Illinois, Dept Psychol, Champaign, IL 61820 USA.
Indiana Univ, Dept Psychol, Bloomington, IN 47405 USA.
RP Wickesberg, RE (reprint author), Univ Illinois, Dept Psychol, 603 E Daniel St, Champaign, IL 61820 USA.
EM jlloebac@indiana.edu; wickesbe@uiuc.edu
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NR 36
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2006
VL 213
IS 1-2
BP 130
EP 144
DI 10.1016/j.heares.2006.01.011
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 028QP
UT WOS:000236503400015
PM 16497455
ER
PT J
AU Ma, WLD
Hidaka, H
May, BJ
AF Ma, WLD
Hidaka, H
May, BJ
TI Spontaneous activity in the inferior colliculus of CBA/J mice after
manipulations that induce tinnitus
SO HEARING RESEARCH
LA English
DT Article
DE sound exposure; salicylate; hyperactivity; spontaneous activity;
auditory nerve; dorsal cochlear nucleus; auditory cortex
ID DORSAL COCHLEAR NUCLEUS; SPONTANEOUS NEURAL ACTIVITY; PRIMARY
AUDITORY-CORTEX; INDUCED HEARING-LOSS; PURE-TONE TRAUMA; C-FOS; INTENSE
SOUND; ANIMAL-MODEL; BEHAVIORAL PARADIGM; RESPONSE PROPERTIES
AB Several physiological studies have linked experimentally induced tinnitus to increases in the spontaneous activity of auditory neurons, These results have led to the proposal of hyperactivity models of tinnitus in which elevated neural activity in the absence of auditory stimulation is perceived as phantom sound. Such models are appealing in their simplicity but remain controversial because a generalized elevation of spontaneous rates may not be observed after treatments that induce tinnitus in humans and experimental animals. Our study addressed these issues by characterizing the effects of common methods of tinnitus induction on spontaneous activity in the central nucleus of the inferior colliculus (ICC). The ICC is an interesting structure in tinnitus research because its diverse inputs include putative generator sites in the dorsal cochlear nucleus, as well as brainstem sources that appear to remain normal after tinnitus induction. Groups of CBA/J mice were subjected to one of three induction methods: bilateral or unilateral sound exposure, and acute salicylate intoxication. Relative to normal baselines, bilaterally exposed mice showed increases in the spontaneous rates of neurons with tuning near the exposure frequency. When the sample was separated into physiologically defined response classes, exposure effects were strongest among neurons with broad excitatory bandwidths. By contrast, salicylate decreased the spontaneous rates of low-frequency neurons with transient sound-evoked activity. Our results suggest that the disordered processes of hearing that give rise to tinnitus do not involve a pervasive elevation of spontaneous activity or a single mode of induction. (c) 2005 Elsevier B.V. All rights reserved.
C1 Johns Hopkins Univ, Ctr Hearing & Balance, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA.
RP May, BJ (reprint author), Johns Hopkins Univ, Ctr Hearing & Balance, Dept Otolaryngol Head & Neck Surg, 720 Rutland Ave, Baltimore, MD 21205 USA.
EM bmay@jhu.edu
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NR 56
TC 65
Z9 67
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 9
EP 21
DI 10.1016/j.heares.2005.10.003
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000002
PM 16307852
ER
PT J
AU Trune, DR
Kempton, JB
Gross, ND
AF Trune, DR
Kempton, JB
Gross, ND
TI Mineralocorticoid receptor mediates glucocorticoid treatment effects in
the autoimmune mouse ear
SO HEARING RESEARCH
LA English
DT Article
DE autoimmune hearing loss; spironolactone; prednisolone; aldosterone;
mineralocorticoid; MRL/MpJ-Fas(lpr) autoimmune mice
ID SENSORINEURAL HEARING-LOSS; MAMMALIAN INNER-EAR; STRIA VASCULARIS;
ALDOSTERONE ANTAGONISTS; COCHLEAR FUNCTION; STEROID TREATMENT; NA+
CHANNELS; RAT COCHLEA; MICE; SPIRONOLACTONE
AB The standard treatment for many hearing disorders is glucocorticoid therapy, although the cochlear mechanisms involved in steroid-responsive hearing loss are poorly understood. Cochlear dysfunction in autoimmune mice has recently been shown to be controlled with the mineralocorticoid aldosterone as effectively as with the glucocorticoid prednisolone. Because aldosterone regulates sodium, potassium, and other electrolyte homeostasis, this implied the restoration of hearing with the mineralocorticoid was due to its impact on cochlear ion transport, particularly in the stria vascularis. This also suggested glucocorticoids may be controlling hearing recovery in part through their binding to the mineralocorticoid receptor in addition to their glucocorticoid receptor-mediated anti-inflammatory and immunosuppressive functions. Therefore, the aim of the present study was to better delineate the role of the mineralocorticoid receptor in steroid control of hearing in the autoimmune mouse. Spironolactone, a mineralocorticoid receptor antagonist, was administered to MRL/MpJ-Fas(lpr) autoimmune mice in combination with either aldosterone or prednisolone to compare their hearing and systemic disease with mice that received either steroid alone. ABR thresholds showed either aldosterone or prednisolone alone preserved hearing in the mice, but spironolactone prevented both steroids from maintaining normal cochlear function. This suggested both steroids are preserving hearing through the mineralocorticoid receptor within the ear to regulate endolymph homeostasis. The spironolactone treatment did not block normal glucocorticoid receptor-mediated immune-suppression functions because mice receiving prednisolone, either with or without spironolactone, maintained normal body weights, hematocrits, and serum immune complexes. Thus, reducing systemic autoimmune disease was not sufficient to control hearing if mineralocorticoid receptor-mediated functions were blocked. It was concluded the inner ear mineralocorticoid receptor is a significant target of glucocorticoids and a factor that should be considered in therapeutic treatments for steroid-responsive hearing loss. (c) 2005 Elsevier B.V. All rights reserved.
C1 Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, Dept Otolaryngol Head & Neck Surg, Portland, OR 97239 USA.
RP Trune, DR (reprint author), Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, Dept Otolaryngol Head & Neck Surg, Mail Code NRC04,3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM truned@ohsu.edu
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NR 58
TC 33
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 22
EP 32
DI 10.1016/j.heares.2005.10.006
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000003
PM 16307853
ER
PT J
AU Manley, GA
AF Manley, GA
TI Spontaneous otoacoustic emissions from free-standing stereovillar
bundles of ten species of lizard with small papillae
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emission; lizard; suppression tuning
ID AUDITORY HAIR-CELLS; NERVE FIBER ACTIVITY; FROG RANA-ESCULENTA; BOBTAIL
LIZARD; TOKAY GECKO; FREQUENCY FLUCTUATIONS; TEMPERATURE-DEPENDENCE;
VARANUS-BENGALENSIS; ACOUSTIC EMISSIONS; MAMMALIAN COCHLEA
AB Spontaneous otoacoustic emissions (SOAE) were measured in 10 lizard species from the families Iguanidae, Agamidae and Anguidae. The typical feature of these papillae is that the hair cells in the higher-frequency papillar regions that produce SOAE are not covered by a tectorial structure. The number of hair cells in the species used here was between 58 and 292 per ear. SOAE could be measured from all species, but some of their characteristics varied with papillar anatomy. Thus very small papillae produced fewer and smaller SOAE than larger papillae. (c) 2005 Elsevier B.V. All rights reserved.
C1 Tech Univ Munich, Lehrstuhl Zool, D-85747 Garching, Germany.
RP Manley, GA (reprint author), Tech Univ Munich, Lehrstuhl Zool, Lichtenbergstr 4, D-85747 Garching, Germany.
EM geoffrey.manley@wzw.tum.de
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NR 72
TC 18
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 33
EP 47
DI 10.1016/j.heares.2005.10.007
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000004
PM 16307854
ER
PT J
AU Furukawa, S
Maki, K
AF Furukawa, S
Maki, K
TI Sensitivity of the auditory middle latency response of the guinea pig to
interaural level and time differences
SO HEARING RESEARCH
LA English
DT Article
DE middle latency response; interaural time difference; interaural level
difference; time-intensity trading; guinea pig
ID BINAURAL INTERACTION; SOUND LOCALIZATION; CORTEX; LATERALIZATION;
COMPONENTS; ANESTHESIA; INTENSITY
AB This study examines the extent to which the auditory middle latency response (MLR) of the guinea pig is sensitive to sound localization cues such as interaural level and time differences (ILD and ITD, respectively). The MLR was recorded with an epidural electrode placed over the auditory cortex of an anesthetized guinea pig. Click stimuli were presented monaurally or binaurally with various ILDs and ITDs. The MLR was much larger for contralateral stimulation than for ipsilateral stimulation, and its amplitude was intermediate for diotic stimulation. The MLR amplitude was sensitive to both ILD and ITD: it decreased as the ipsilateral stimulus increased in level or advanced in time relative to the contralateral stimulus. The steep slope of the amplitude-versus-ITD function fell within an ITD range of +/- 330 mu s, namely the guinea pig's physiological ITD range. The response reduction that resulted from increasing the relative level of the ipsilateral level could be cancelled out by advancing the contralateral onset time relative to the ipsilateral onset time. This parallels the "time-intensity trading" in sound lateralization exhibited in human psychophysics. The results imply that the binaural interaction in the guinea pig MLR reflects aspects of neural processes that are involved in sound localization. (c) 2005 Elsevier B.V. All rights reserved.
C1 NTT Corp, Human & Informat Sci Lab, NTT Commun Sci Labs, Atsugi, Kanagawa 2430198, Japan.
RP Furukawa, S (reprint author), NTT Corp, Human & Informat Sci Lab, NTT Commun Sci Labs, 3-1 Morinosato Wakamiya, Atsugi, Kanagawa 2430198, Japan.
EM shig@avg.brl.ntt.co.jp; maki@avg.brl.ntt.co.jp
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TOBIAS JV, 1959, J ACOUST SOC AM, V31, P1959
NR 21
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 48
EP 57
DI 10.1016/j.heares.2005.10.009
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000005
PM 16324809
ER
PT J
AU Boettcher, FA
Emery, M
AF Boettcher, FA
Emery, M
TI Auditory evoked-potential correlates of decrement detection
SO HEARING RESEARCH
LA English
DT Article
DE decrement detection; intensity discrimination; auditory brainstem
response; ABR; auditory evoked potentials; gap detection
ID AGE-RELATED-CHANGES; HEARING-IMPAIRED LISTENERS; SHORT-TERM ADAPTATION;
MONGOLIAN GERBIL; GAP DETECTION; FREQUENCY; NOISE; DURATION; YOUNG;
DISCRIMINATION
AB Decrement detection is a commonly used psychophysical technique in which a subject is required to detect partially filled gaps in an ongoing Sound. The paradigm provides information regarding both temporal resolution and intensity discrimination. The purpose of this project was to determine if an evoked-potential paradigm using decrements in an ongoing noise approximates psychophysical data. If so, the evoked-response paradigm would be useful in estimating decrement detection in laboratory animals, where training time for a psychophysical model of decrement detection might prove prohibitive. In this study, Mongolian gerbils aged 3-10 months were used as subjects. The stimulus was a broadband noise (low-pass filtered at 5 or 30 kHz, overall level of 70 dB SPL), interrupted for durations of 232 ms. Within each off period, a second, identically filtered noise at levels of 0-70 dB SPL was presented. In a manner qualitatively similar to previous human and animal psychophysical studies, the ABR threshold decreased as the duration of the decrement was increased. Latency and amplitudes changed as a function of decrement duration when the decrement depth was held constant, but minimal change as a function of decrement depth occurred when the decrement duration was held constant. The results suggest that ABR paradigm for decrement detection is a qualitative alternative to psychophysical techniques, but that amplitude and latency data may not provide more information on temporal and intensity coding than ABR measures of gap detection. (c) 2005 Elsevier B.V. All rights reserved.
C1 Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
RP Boettcher, FA (reprint author), Med Univ S Carolina, Dept Otorhinolaryngol Head & Neck Surg, 39 Sabin St,POB 250150, Charleston, SC 29425 USA.
EM fboettcher@usouthal.edu
CR Boettcher FA, 1996, HEARING RES, V102, P167, DOI 10.1016/S0378-5955(96)90016-7
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BOETTCHER FA, 1993, HEARING RES, V71, P146, DOI 10.1016/0378-5955(93)90030-5
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NR 28
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 58
EP 64
DI 10.1016/j.heares.2005.10.011
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000006
PM 16403610
ER
PT J
AU Killan, EC
Kapadia, S
AF Killan, EC
Kapadia, S
TI Simultaneous suppression of tone burst-evoked otoacoustic emissions -
Effect of level and presentation paradigm
SO HEARING RESEARCH
LA English
DT Article
DE transient-evoked otoacoustic emissions; suppression; tone bursts
ID STIMULUS-FREQUENCY; COCHLEAR MECHANICS; 2-TONE SUPPRESSION; ACOUSTIC
EMISSIONS; NORMAL-HEARING; CLICK; DISTORTION; MODEL; EARS; ORIGIN
AB There is conflict in the literature over whether individual frequency components of a transient-evoked otoacoustic emission (TEOAE) are generated within relatively independent "channels" along the basilar membrane (BM), or whether each component may be generated by widespread areas of the BM. Two previous studies on TEOAE suppression are consistent with generation within largely independent channels, but with a degree of interaction between nearby channels. However, both these studies reported significant suppression only at high stimulus levels, at which the "nonlinear" presentation paradigm was used. The present study clarifies the separate influences of stimulus level and presentation paradigm on this type of suppression. TEOAEs were recorded using stimulus tone bursts at 1, 2 and 3 kHz and a complex stimulus consisting of a digital addition of the three tone bursts, over a range of stimulus levels and both "linear" and "nonlinear" presentation paradigms. Responses to the individual tone bursts were combined offline and compared with responses to the complex stimuli. Results clearly demonstrate that TEOAE suppression under these conditions is dependent upon stimulus level, and not upon presentation paradigm. It is further argued that the data support the "local" rather than "widespread" model of TEOAE generation, subject to nonlinear interactions between nearby generation channels. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Leeds, Sch Healthcare, Leeds LS2 9UT, W Yorkshire, England.
Univ Southampton, Inst Sound & Vibrat Res, Southampton SO17 1BJ, Hants, England.
RP Killan, EC (reprint author), Univ Leeds, Sch Healthcare, Leeds LS2 9UT, W Yorkshire, England.
EM e.killan@leeds.ac.uk
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NR 25
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 65
EP 73
DI 10.1016/j.heares.2005.10.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000007
PM 16324810
ER
PT J
AU Paasche, G
Bogel, L
Leinung, M
Lenarz, T
Stover, T
AF Paasche, G
Bogel, L
Leinung, M
Lenarz, T
Stover, T
TI Substance distribution in a cochlea model using different pump rates for
cochlear implant drug delivery electrode prototypes
SO HEARING RESEARCH
LA English
DT Article
DE drug delivery; cochlea implant electrode array; multiple outlets;
substance distribution
ID HAIR CELL LOSS; ADENOVIRUS-MEDIATED OVEREXPRESSION; NEURONS IN-VITRO;
INNER-EAR; NEUROTROPHIC FACTOR; TECHNICAL REPORT; HEARING-LOSS;
OUTGROWTH; INFUSION; SURVIVAL
AB Several studies using animals have shown the protective effects of neurotrophic factors (NF) on spiral ganglion cells (SGC). This is of particular importance since the number of SGCs is considered to be among the factors defining the efficacy of cochlear implants. A device for local inner ear treatment is therefore of great interest. As described previously, we modified a Contour (TM) cochlear implant electrode, to examine the inbuilt canal to be used for fluid release [Paasche, G., Gibson, P., Averbeck, T., Becker, H., Lenarz, T., Stover, T., 2003. Technical report: modification of a cochlear implant electrode for drug delivery to the inner ear. Otol. Neurotol. 24, 222-227]. In the present study, three different electrode prototypes with openings of the delivery channel at various locations along the electrode array were examined to determine distribution of dye in a cochlea model over time. We compared dye delivery with: (a) release of the dye at the tip, (b) release of the dye at the tip and the side of the electrode, and (c) release of the dye only at the side of the electrode (6 mm from the tip). A mechanical pump was used to drive the system at pump rates of 100, 10, and 1 mu l/h. Dye concentration changes along the length of the whole cochlea were investigated. Mean values for all experimental conditions show that the distribution along the array is fastest with two outlets whereas the distribution via a single outlet at the side of the electrode array is not considered to be sufficient. The established experimental setup provides the possibility of investigating prototypes of a fluid based drug delivery system for the treatment of inner ear pathologies in combination with electrical stimulation. (c) 2005 Elsevier B.V. All rights reserved.
C1 Hannover Med Sch, Dept Otolaryngol, D-30625 Hannover, Germany.
RP Paasche, G (reprint author), Hannover Med Sch, Dept Otolaryngol, OE 6500,Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM Paasche.Gerrit@MH-Hannover.de
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NR 24
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 74
EP 82
DI 10.1016/j.heares.2005.10.013
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000008
PM 16337758
ER
PT J
AU Stuart, A
Jones, SM
Walker, LJ
AF Stuart, A
Jones, SM
Walker, LJ
TI Insights into elevated distortion product otoacoustic emissions in
sickle cell disease: Comparisons of hydroxyurea-treated and non-treated
young children
SO HEARING RESEARCH
LA English
DT Article
DE distortion product otoacoustic emissions; sickle cell disease;
hydroxyurea
ID SENSORINEURAL HEARING-LOSS; INNER-EAR; CONTRALATERAL SUPPRESSION;
COCHLEAR ISCHEMIA; AUDITORY FUNCTION; ADHESION MOLECULE-1; IMPAIRED
SUBJECTS; ANEMIA PATIENTS; HUMAN LISTENERS; BLOOD-CELLS
AB Distortion product otoacoustic emissions (DPOAEs) were examined in 15 normal-hearing African-American children between the ages of 6 and 14 years with homozygous sickle cell disease (SCD), who were on a regimen of hydroxyurea (HDU), a drug that reduces inflammatory processes and symptoms of SCD; a matched group of 15 African-American children with homozygous SCD not on HDU; and 15 African-American children with normal hemoglobin. DPOAEs were evoked by 13 primary tone pairs with f(2) frequencies ranging from 1000 to 4500 Hz. Increased DPOAE amplitudes, believed to be a precursor of eventual hearing loss, were evident in children with SCID who were not receiving HDU. Those taking HDU had DPOAE amplitudes similar to normal controls. These findings suggest that HDU, in addition to reducing symptoms of SCD, may play a role in inhibiting or preventing cochlear pathology and hearing loss in individuals with SCID. (c) 2005 Elsevier B.V. All rights reserved.
C1 E Carolina Univ, Sch Allied Hlth Sci, Dept Commun Sci & Disorders, Greenville, NC 27858 USA.
Missouri State Univ, Dept Commun Sci & Disorders, Springfield, MO USA.
RP Stuart, A (reprint author), E Carolina Univ, Sch Allied Hlth Sci, Dept Commun Sci & Disorders, Belk Annex, Greenville, NC 27858 USA.
EM stuarta@mail.ecu.edu
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NR 76
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 83
EP 89
DI 10.1016/j.heares.2005.10.014
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000009
PM 16364581
ER
PT J
AU Groh, D
Pelanova, J
Jilek, M
Popelar, J
Kabelka, Z
Syka, J
AF Groh, D
Pelanova, J
Jilek, M
Popelar, J
Kabelka, Z
Syka, J
TI Changes in otoacoustic emissions and high-frequency hearing thresholds
in children and adolescents
SO HEARING RESEARCH
LA English
DT Article
DE children; adolescents; audiograms; otoacoustic emissions
ID DISTORTION-PRODUCT; DEVELOPMENTAL-CHANGES; BASIC CHARACTERISTICS;
AUDITORY THRESHOLD; INFANTS; AGE; ADULTS; SENSITIVITY; PRESBYCUSIS;
SYSTEM
AB With the aim of characterizing the loss of high frequency hearing sensitivity in children, hearing thresholds and otoacoustic emissions were measured in a group of 126 normal hearing children and adolescents aged from 6 to 25 years. The subjects were divided into four 5-year age groups. Hearing thresholds over a range of 125 Hz-12.5 kHz were similar in all age groups, the average hearing threshold at 16 kHz was significantly elevated in the oldest age group. The response values of transiently evoked otoacoustic emissions (TEOAEs) significantly declined with age; the decline was negatively correlated with the hearing loss at 16 kHz. Significantly larger TEOAE responses and average distortion-product otoacoustic emission (DPOAE) values at 6.3 kHz were present in the youngest group in comparison with the other three older groups. Spontaneous otoacoustic emissions (SOAEs) were present in 70.8% of the children (in either one or both ears) with the greatest prevalence in the 11-20-year-old subjects. In the 21-25-year-old group, the hearing loss at 16 kHz was significantly smaller in ears with SOAEs than in ears without SOAEs. The results demonstrate that the increase in the high frequency hearing threshold at 16 kHz, which starts at ages over 20 years, is correlated with a decrease in the TEOAE responses at middle frequencies. (c) 2005 Elsevier B.V. All rights reserved.
C1 Acad Sci Czech Republ, Inst Expt Med, Dept Auditory Neurosci, Prague 14220 4, Czech Republic.
Charles Univ, ENT Dept, Fac Med 2, Prague 15006 5, Czech Republic.
Univ Hosp Motol, Prague 15006 5, Czech Republic.
RP Syka, J (reprint author), Acad Sci Czech Republ, Inst Expt Med, Dept Auditory Neurosci, Videnska 1083, Prague 14220 4, Czech Republic.
EM daniel.groh@lfmotol.cuni.cz; pelanova@biomed.cas.cz;
jilek@biomed.cas.cz; jpopelar@biomed.cas.cz;
zdenek.kabelka@lfmotol.cuni.cz; syka@biomed.cas.cz
RI Popelar, Jiri/H-2558-2014; Syka, Josef/H-3103-2014
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NR 48
TC 11
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 90
EP 98
DI 10.1016/j.heares.2005.11.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000010
PM 16364580
ER
PT J
AU Severinsen, SA
Kirkegaard, M
Nyengaard, JR
AF Severinsen, SA
Kirkegaard, M
Nyengaard, JR
TI 2,3-Dihydroxybenzoic acid attenuates kanamycin-induced volume reduction
in mouse utricular type I hair cells
SO HEARING RESEARCH
LA English
DT Article
DE inner ear; mice; stereology; utricular macula; volume; otoprotection
ID VESTIBULAR SENSORY EPITHELIA; CHINCHILLA CRISTA-AMPULLARIS; INNER-EAR;
IRON CHELATORS; AMINOGLYCOSIDE OTOTOXICITY; GENTAMICIN OTOTOXICITY;
POSTNATAL-DEVELOPMENT; PATHOLOGICAL RESEARCH; GUINEA-PIGS; NUMBER
AB The aminoglycoside kanamycin is a commonly used antibiotic, but unfortunately it is oto- and nephrotoxic in large doses. The negative effects are thought to be due to the formation of free radicals which is why strong antioxidants and iron chelators like 2,3-dihydroxybenzoic acid (DHB) are of great interest. This study estimates cellular quantitative changes in the utricular macula of mice following systemic treatment with kanamycin alone or in combination with DHB. The animals were injected with either saline, kanamycin or kanamycin + DHB for 15 days and perfusion fixed three weeks after last injection. Total volume of the utricle, as well as total number of hair and supporting cells, were estimated on light microscopic sections. Total volume and mean volume of hair cell types I and II and supporting cells were estimated on digital transmission electron micrographs. Total volume of the utricular macula, hair cell type I and supporting cells decreased significantly in animals injected with kanamycin but not in animals co-treated with DHB. Hair and supporting cell numbers remained unchanged in all three groups. In conclusion, the kanamycin-induced volume reduction of type I hair cells was attentuated by DHB. (c) 2005 Elsevier B.V. All rights reserved.
C1 Aarhus Univ, Stereol & Electron Microscopy Res Lab, DK-8000 Aarhus C, Denmark.
Aarhus Univ, MIND Ctr, Inst Clin Med, DK-8000 Aarhus, Denmark.
Karolinska Univ Hosp, Ctr Hearing & Commun Res, Stockholm, Sweden.
RP Severinsen, SA (reprint author), Aarhus Univ, Stereol & Electron Microscopy Res Lab, Bldg 1185, DK-8000 Aarhus C, Denmark.
EM stig.severinsen@ki.au.dk
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NR 46
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 99
EP 108
DI 10.1016/j.heares.2005.10.016
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000011
PM 16377109
ER
PT J
AU El-Kady, MA
Durrant, JD
Tawfik, S
Abdel-Ghany, S
Moussa, AM
AF El-Kady, MA
Durrant, JD
Tawfik, S
Abdel-Ghany, S
Moussa, AM
TI Study of auditory function in patients with chronic obstructive
pulmonary diseases
SO HEARING RESEARCH
LA English
DT Article
DE hypoxia; hypoxemia; chronic obstructive pulmonary disease;
electrocochleography; auditory brain-stem response; otoacoustic
emissions; audiometry
ID EVOKED OTOACOUSTIC EMISSIONS; OUTER HAIR-CELLS; COCHLEAR-POTENTIALS;
SUMMATING POTENTIALS; ACOUSTIC NEUROMAS; HYPOXIA; OXYGEN; RESPONSES;
ANOXIA; INNER
AB This study was designed to measure auditory function in patients with chronic obstructive pulmonary diseases (COPDs) who generally suffer from chronic hypoxemia. Control and COPD subject groups received a battery of tests to assess overall hearing sensitivity and peripheral (end-organ and eighth-nerve) and brain-stem auditory function, as well as blood-gas analysis. Results showed a statistically significant difference for all audiological measures between the control group and a COPD subgroup - the presumptive hypoxic subjects (partial oxygen tensions, PO2, < 75 mm Hg). Correlation analyses of results from all subjects (regardless Of PO2) also revealed significant covariance with PO2 for overall, RMS, amplitude of click-evoked otoacoustic emissions (RA), hearing threshold level, and auditory brain-stem response (ABR, I-V inter-peak latency). chi(2) or Fisher's exact tests were statistically significant for frequencies of cases classified according to a criterion PO2 of 70 mm Hg (putative critical O-2 for completely normal auditory function) and either hearing thresholds falling below or RA values above 1.5 standard deviations of the control-group means, respectively. However, chi(2) was not significant for a comparable criterion of ABR IN IPL. In general, clinically significant hearing loss was uncommon in COPD patients, and the observed effects represented relatively small changes in the auditory measures examined. Still, overall, changes were in the direction of poorer function, and these results suggest physiologically significant impact of chronic hypoxemia and the need for further study to evaluate thoroughly this medical condition as a potential risk factor for audio-vestibular dysfunction. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Pittsburgh, Dept Commun Sci & Disorders & Otolaryngol, Pittsburgh, PA 15260 USA.
Univ Pittsburgh, Dept Commun Sci & Disorders, Pittsburgh, PA 15260 USA.
Ain Shams Univ, Dept Audiol, Cairo, Egypt.
Sohag Univ Hosp, Dept Chest Dis, Sohag, Egypt.
Sohag Univ Hosp, Dept Otolaryngol, Sohag, Egypt.
RP Durrant, JD (reprint author), Univ Pittsburgh, Dept Commun Sci & Disorders & Otolaryngol, Forbes Tower 4033, Pittsburgh, PA 15260 USA.
EM durrant@pitt.edu
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NR 43
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 109
EP 116
DI 10.1016/j.heares.2005.05.018
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000012
PM 16412595
ER
PT J
AU Morawski, K
Telischi, FF
Niemczyk, K
AF Morawski, K
Telischi, FF
Niemczyk, K
TI A model of real time monitoring of the cochlear function during an
induced local ischemia
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emissions; cochlear blood flow; cochlear ischemia; cochlear
reperfusion
ID PRODUCT OTOACOUSTIC EMISSIONS; ACOUSTIC NEUROMA SURGERY; OUTER
HAIR-CELLS; AUDITORY-EVOKED POTENTIALS; LASER-LIGHT TRANSMISSION; 2
DISCRETE SOURCES; BLOOD-FLOW; GUINEA-PIG; PHYSIOLOGICAL VULNERABILITY;
DISTORTION PRODUCTS
AB The aim of this study was to investigate the utility of distortion product otoacoustic emissions (DPOAEs) in intraoperative monitoring (IM) of cochlear ischemic episodes in animals during internal auditory artery (IAA) compression. The IAA was exposed using the posterior fossa approach and then compressed for 3 and 5 min intervals to effect ischemia. DPOAE amplitudes and phases were measured at 4, 8, and 12 kHz geometric mean frequency (GMF). In each monitored ear, laser-Doppler cochlear blood flow (CBF) was measured. All IAA compressions resulted in rapid decrease of DPOAE amplitude and CBF, with simultaneous DPOAE phase increase. DPOAE phase changes were found to increase consistently within several seconds of IAA compression, while corresponding DPOAE amplitudes changed more slowly, with up to 30-40 s delays. Following IAA release, DPOAEs at 12 kHz GMF were characterized by longer delays in returning to baseline than those measured at lower frequencies. In some cases, CBF did not return to baseline. In this animal model, DPOAEs were found to be sensitive measures of cochlear function during transient cochlear ischemic episodes, suggesting the utility of DPOAE monitoring of auditory function during surgery of cerebello-pontine angle tumors. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Miami, Ear Inst, Dept Otolaryngol D48, Miami, FL 33101 USA.
Med Univ Warsaw, Dept Otolaryngol, PL-02097 Warsaw, Poland.
RP Telischi, FF (reprint author), Univ Miami, Ear Inst, Dept Otolaryngol D48, POB 016960, Miami, FL 33101 USA.
EM ftelisch@med.miami.edu
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NR 68
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 117
EP 127
DI 10.1016/j.heares.2005.05.019
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000013
PM 16403609
ER
PT J
AU Drayton, M
Noben-Trauth, K
AF Drayton, M
Noben-Trauth, K
TI Mapping quantitative trait loci for hearing loss in Black Swiss mice
SO HEARING RESEARCH
LA English
DT Article
DE outbred strains; hearing loss; quantitative trait loci; cadherin 23;
protocadherin 15
ID INBRED STRAINS; GENETIC DISSECTION; COMPLEX TRAITS; AMES WALTZER;
INNER-EAR; MOUSE; MUTATION; MODEL; IDENTIFICATION; IMPAIRMENT
AB In common inbred mouse strains, hearing loss is a highly prevalent quantitative trait, which is mainly controlled by the Cdh23(753A) variant and alleles at numerous other strain-specific loci. Here, we investigated the genetic basis of hearing loss in non-inbred strains. Mice of Swiss Webster, CF-1, NIH Swiss, ICR, and Black Swiss strains exhibited hearing profiles characteristic of progressive, sensorineural hearing impairment. In particular, CF-1, Black Swiss, and NIH Swiss mice showed early-onset hearing impairment, ICR and Swiss Webster mice expressed a delayed-onset hearing loss, and NMRI mice had normal hearing. By quantitative trait locus (QTL) mapping, two significant QTLs were identified underlying hearing loss in Black Swiss mice: one QTL mapped to chromosome (chr) 10 (named ahl5, LOD 8.9, peak association 35-42 cM) and a second QTL localized to chr 18 (ahl6, LOD 3.8, 38-44 cM). Ahl5 and ahl6 account for 61% and 32% of the variation in the backcross, respectively. Cadherin 23 (Cdh23) and protocadherin 15 (Pedh15), mapping within the 95% confidence interval of ahl5, bear nucleotide polymorphisms in coding exons, but these appear to be unrelated to the hearing phenotype. Haplotype analyses across the Cdh23 locus demonstrated the phylogenetic relationship between Black Swiss and common inbred strains. (c) 2005 Elsevier B.V. All rights reserved.
C1 Natl Inst Deafness & Other Commun Disorders, Neurogenet Sect, Mol Biol Lab, NIH, Rockville, MD 20850 USA.
RP Noben-Trauth, K (reprint author), Natl Inst Deafness & Other Commun Disorders, Neurogenet Sect, Mol Biol Lab, NIH, 5 Res Court, Rockville, MD 20850 USA.
EM nobentk@nidcd.nih.gov
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NR 28
TC 25
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 128
EP 139
DI 10.1016/j.heares.2005.11.006
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000014
PM 16426780
ER
PT J
AU Farahbakhsh, NA
Narins, PM
AF Farahbakhsh, NA
Narins, PM
TI Slow motility in hair cells of the frog amphibian papilla:
Ca2+-dependent shape changes
SO HEARING RESEARCH
LA English
DT Article
DE auditory hair cells; iso-volumetric contraction; osmotic shortening
ID GUINEA-PIG COCHLEA; MOTOR PROTEIN; ACETYLCHOLINE; ELECTROMOTILITY;
CALCIUM; PRESTIN; MECHANISMS; STIFFNESS; CURRENTS; LENGTH
AB We investigated the process of slow motility in non-mammalian auditory hair cells by recording the time course of shape change in hair cells of the frog amphibian papilla. The tall hair cells in the rostral segment of this organ, reported to be the sole recipients of efferent innervation, were found to shorten in response to an increase in the concentration of the intracellular free calcium. These shortenings are composed of two partially-overlapping phases: an initial rapid iso-volumetric contraction, followed by a slower length decrease accompanied with swelling. It is possible to unmask the iso-volumetric contraction by delaying the cell swelling with the help of K+ or Cl- channel inhibitors, quinine or furosemide. Furthermore, it appears that the longitudinal contraction in these cells is Ca2+-calmodulin-dependent: in the presence of W-7, a calmodulin inhibitor, only a slow, swelling phase could be observed. These findings suggest that amphibian rostral AP hair cells resemble their mammalian counterparts in expressing both a Ca2+-calmodulin-dependent contractile structure and an "osmotic" mechanism capable of mediating length change in response to extracellular stimuli. Such a mechanism might be utilized by the efferent neurotransmitters for adaptive modulation of mechano-electrical transduction, sensitivity enhancement, frequency selectivity, and protection against over-stimulation. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
RP Farahbakhsh, NA (reprint author), Univ Calif Los Angeles, Dept Physiol Sci, 621 Charles E Young Dr S, Los Angeles, CA 90095 USA.
EM farahbak@ucla.edu
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NR 58
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 140
EP 159
DI 10.1016/j.heares.2005.11.004
PG 20
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000015
PM 16426781
ER
PT J
AU Cohen, LT
Saunders, E
Knight, MR
Cowan, RSC
AF Cohen, LT
Saunders, E
Knight, MR
Cowan, RSC
TI Psychophysical measures in patients fitted with Contour (TM) and
straight Nucleus electrode arrays
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; perimodiolar placement; radial distance; pitch
estimation; loudness estimation; spread of neural excitation; forward
masking
ID COCHLEAR IMPLANT RECIPIENTS; NEURAL EXCITATION; SPATIAL SPREAD; MASKING;
STIMULATION; POSITION
AB The objective of this study was to compare the psychophysical performance of patients using the Nucleus Contour (TM) electrode array with that of patients using the straight banded-electrode array. In particular, we wished to consider how psychophysical parameters would differ for an electrode array positioned closer to the modiolus, and how this might influence both patient benefits and the design of speech processing strategies. Nine subjects participated in the study: four used the Nucleus straight array and five used the Nucleus Contour electrode array. Radiographic analyses found that the Contour array lay closer to the modiolus, was more deeply inserted and spanned a larger fractional length of the basilar membrane than the straight banded-electrode array. The results were analysed in terms of array type and of the position of the individual electrode band, both distance from the modiolus and longitudinal placement. Mean threshold was lower for the Contour array but maximum comfortable level was similar. Whereas threshold varied significantly with distance of electrode band from the modiolus, maximum comfortable level did not. Pitch varied fairly regularly with longitudinal position of the stimulated electrode, with the exception of one Contour subject. The forward masking profiles, using moderately loud maskers, were narrower for the Contour array, indicative of more localized neural excitation. (c) 2005 Elsevier B.V. All rights reserved.
C1 Cooperat Res Ctr Cochlear Implant & Hearing Aid I, Melbourne, Vic 3002, Australia.
Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
Dynam Hearing, Richmond, Vic 3121, Australia.
Cochlear Ltd, Melbourne, Vic 3002, Australia.
RP Cohen, LT (reprint author), Cooperat Res Ctr Cochlear Implant & Hearing Aid I, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM ltcohen@unimelb.edu.au
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NR 30
TC 31
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 160
EP 175
DI 10.1016/j.heares.2005.11.005
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000016
PM 16403611
ER
PT J
AU Bleeck, S
Sayles, M
Ingham, NJ
Winter, IM
AF Bleeck, S
Sayles, M
Ingham, NJ
Winter, IM
TI The time course of recovery from suppression and facilitation from
single units in the mammalian cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE adaptation; forward masking; auditory brainstem; onset unit;
primary-like; chopper
ID AUDITORY-NERVE FIBERS; TONE-BURST; NEURONS; RESPONSES; MASKING;
ADAPTATION; CLASSIFICATION; REGULARITY; INTENSITY; INVITRO
AB The responses to two identical, consecutive pure tone stimuli with varying inter-stimulus intervals (Delta ts) were measured for 89 neurons in the cochlear nucleus of the anaesthetised guinea pig. We observed two main effects; either a decrease (suppression) or an increase (facilitation) in response to the second tone followed by an exponential recovery. Response behaviour correlated with the unit type; primary-like, primary-like with notch and transient-chopper units showed a recovery from suppression that was very similar to that already reported in the auditory nerve. For chopper units the strength of the adaptation was correlated with the units regularity of spike discharge; sustained chopper (CS) units showed less suppression than transient choppers. Onset units showed complete suppression at short Delta ts. Pause/Build (PB) units responded with increased activity to the second tone. In contrast to previous studies in the cochlear nucleus the recovery from suppression or facilitation was well described by a single exponential function, enabling us to define a recovery time constant and a maximum suppression/facilitation. There appeared to be a hierarchy in the time constant of recovery with PB and CS units showing the longest recovery times and onset units showing the shortest. (c) 2006 Elsevier B.V. All rights reserved.
C1 Physiol Lab, Ctr Neural Basis Hearing, Cambridge CB2 3EG, England.
Univ Southampton, Inst Sound & Vibrat Res, Southampton SO17 1BJ, Hants, England.
RP Winter, IM (reprint author), Physiol Lab, Ctr Neural Basis Hearing, Downing St, Cambridge CB2 3EG, England.
EM imw1001@cam.ac.uk
RI Bleeck, Stefan/A-1178-2013
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NR 25
TC 19
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 176
EP 184
DI 10.1016/j.heares.2005.12.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000017
PM 16458460
ER
PT J
AU Sininger, YS
Cone-Wesson, B
AF Sininger, YS
Cone-Wesson, B
TI Lateral asymmetry in the ABR of neonates: Evidence and mechanisms
SO HEARING RESEARCH
LA English
DT Article
DE auditory brainstem response; neonates; ear asymmetry; medial
olivocochlear system
ID BRAIN-STEM RESPONSE; SPONTANEOUS OTOACOUSTIC EMISSIONS; MEDIAL
OLIVOCOCHLEAR SYSTEM; AUDITORY EVOKED-POTENTIALS; HEARING IMPAIRMENT;
GENDER DIFFERENCES; SEX-DIFFERENCES; STIMULUS RATE; INFANTS; MASKING
AB Lateralized processing of auditory stimuli occurs at the level of the auditory cortex but differences in function between the left and right sides are not clear at lower levels of the auditory system. The current Study is designed to (1) investigate asymmetric auditory function at the ear and brainstem in human infants and (2) investigate possible mechanisms for asymmetry at these levels. Study I evaluated auditory brainstem responses (ABRs) in response to high and low-level clicks presented to the right and left ears of neonates. Wave V was significantly larger in amplitude and waves III and V were shorter in latency when the ABR was generated in the right ear. Study 2 investigated two possible mechanisms of such asymmetry by (a) using contralateral white noise masking to activate the medial olivocochlear system and (b) increasing stimulus rate to reveal neural conduction and synaptic mechanisms. ABR wave V, evoked by clicks to the left ear, showed a greater reduction in amplitude with contralateral noise than the response evoked from the right ear. No systematic asymmetries in ABR latencies or amplitudes were found with increased stimulus rate. We conclude that (1) the click-evoked ABR in neonates demonstrates asymmetric auditory function with a small but significant right ear advantage and (2) asymmetric activation of the medial olivocochlear system, specifically greater contralateral suppression of ABR produced by the left ear, is a possible mechanism for asymmetry. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, Ctr Hlth Sci 62132, Los Angeles, CA 90095 USA.
Univ Arizona, Dept Speech Language & Hearing Sci, Tucson, AZ 85721 USA.
RP Sininger, YS (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Div Head & Neck Surg, Ctr Hlth Sci 62132, Box 951624, Los Angeles, CA 90095 USA.
EM ysininger@mednet.ucla.edu
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NR 41
TC 25
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 203
EP 211
DI 10.1016/j.heares.2005.12.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000019
PM 16439078
ER
PT J
AU Kurt, S
Crook, JM
Ohl, FW
Scheich, H
Schulze, H
AF Kurt, S
Crook, JM
Ohl, FW
Scheich, H
Schulze, H
TI Differential effects of iontophoretic in vivo application of the
GABA(A)-antagonists bicuculline and gabazine in sensory cortex
SO HEARING RESEARCH
LA English
DT Article
DE primary auditory cortex; spectral tuning; temporal processing;
intracortical inhibition; SR95531
ID PRIMARY AUDITORY-CORTEX; CAT VISUAL-CORTEX; FUNCTIONALLY CHARACTERIZED
SITES; GERBIL MERIONES-UNGUICULATUS; RECEPTIVE-FIELDS; DIRECTION
SELECTIVITY; RESPONSE PROPERTIES; MONGOLIAN GERBIL; COMPETITIVE
ANTAGONIST; INHIBITORY MECHANISMS
AB We have compared the effects of microiontophoretic application of the GABA(A)-receptor antagonists bicuculline (BIC) and gabazine (SR95531) on responses to pure tones and to sinusoidally amplitude-modulated (AM) tones in cells recorded extracellularly from primary auditory cortex (AI) of Mongolian gerbils. Besides similar effects in increasing spontaneous and stimulus-evoked activity and their duration, both drugs elicited differential effects on spectral tuning and synchronized responses to AM tones. In contrast to gabazine, iontophoresis of the less potent GABA(A)-antagonist BIC often resulted in substantial broadening of frequency tuning for pure tones and an elimination of synchronized responses to AM tones, particularly with high ejecting currents. BIC-induced effects which could not be replicated by application of gabazine were presumably due to the well-documented, non-GABAergic side-effects of BIC on calcium-dependent potassium channels. Our results thus provide strong evidence that GABA(A)-mediated inhibition in AI does not sharpen frequency tuning for pure tones, but rather contributes to the processing of fast temporal modulations of sound envelopes. They also demonstrate that BIC can have effects on neuronal response selectivity which are not due to blockade of GABAergic inhibition. The results have profound implications for microiontophoretic studies of the role of intracortical inhibition in sensory cortex. (c) 2006 Elsevier B.V. All rights reserved.
C1 Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany.
Univ Newcastle Upon Tyne, Div Psychol, Sch Biol & Psychol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
RP Schulze, H (reprint author), Leibniz Inst Neurobiol, Brenneckestr 6, D-39118 Magdeburg, Germany.
EM Holger.Schulze@IfN-Magdeburg.de
RI Kurt, Simone/I-2927-2012
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NR 58
TC 35
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 224
EP 235
DI 10.1016/j.heares.2005.12.002
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000021
PM 16442250
ER
PT J
AU Hahn, H
Kammerer, B
DiMauro, A
Salt, AN
Plontke, SK
AF Hahn, H
Kammerer, B
DiMauro, A
Salt, AN
Plontke, SK
TI Cochlear microdialysis for quantification of dexamethasone and
fluorescein entry into scala tympani during round window administration
SO HEARING RESEARCH
LA English
DT Article
DE round window membrane; permeability; pharmacokinetics; inner ear;
microdialysis; perilymph; drug delivery; dexamethasone; steroid
ID SENSORINEURAL HEARING-LOSS; GUINEA-PIG COCHLEA; INNER-EAR; INTRATYMPANIC
DEXAMETHASONE; MENIERES-DISEASE; DRUG-DELIVERY; PHARMACOKINETICS;
MEMBRANE; GENTAMICIN; PERILYMPH
AB Before new drugs for the treatment of inner car disorders can be studied in controlled clinical trials, it is important that their pharmacokinetics be established in inner ear fluids. Microdialysis allows drug levels to be measured in perilymph without the volume disturbances and potential cerebrospinal fluid contamination associated with fluid sampling. The aims of this study were to show: (i) that despite low recovery rates from miniature dialysis probes, significant amounts of drug are removed from small fluid compartments, (ii) that dialysis sampling artifacts can be accounted for using computer simulations and (iii) that microdialysis allows quantification of the entry rates through the round window membrane (RWM) into scala tympani (ST). Initial experiments used microdialysis probes in small compartments in vitro containing sodium fluorescein. Stable concentrations were observed in large compartments (1000 mu l) but significant concentration declines were observed in smaller compartments (100, 10 and 5.6 mu l) comparable to the size of the inner ear. Computer simulations of these experiments closely approximated the experimental data. In in vivo experiments, sodium fluorescein 10 mg/ml and dexamethasone-dihydrogen-phosphate disodium salt 8 mg/ml were simultaneously applied to the RWM of guinea pigs. Perilymph concentration in the basal turn of ST was monitored using microdialysis. The fluorescein concentration reached after 200 min application (585 +/- 527 mu g/ml) was approximately twice that of dexamethasone phosphate (291 +/- 369 mu g/ml). Substantial variation in concentrations was found between animals by approximately a factor of 34 for fluorescein and at least 41 for dexamethasone phosphate. This is, to a large extent, thought to be the result of the RWM permeability varying in different animals. It was not caused by substance analysis variations, because two different analytic methods were used and the concentration ratio between the two substances remained nearly constant across the experiments and because differences were apparent for the repeated samples obtained in each animal. Interpretation of the results using computer simulations allowed RWM permeability to be quantified. It also demonstrated, however, that cochlear clearance values could not be reliably obtained with microdialysis because of the significant contribution of dialysis to clearance. The observed interanimal variation, e.g., in RWM permeability, is likely to be clinically relevant to the local application of drugs in patients. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, D-72076 Tubingen, Germany.
Univ Tubingen, Div Clin Pharmacol, Inst Pharmacol & Toxicol, D-72076 Tubingen, Germany.
Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Plontke, SK (reprint author), Univ Tubingen, Dept Otorhinolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, Elfriede Aulhorn Str 5, D-72076 Tubingen, Germany.
EM Stefan.Plontke@uni-tuebingen.de
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NR 45
TC 31
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 236
EP 244
DI 10.1016/j.heares.2005.12.001
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000022
PM 16442251
ER
PT J
AU Macias, S
Mora, EC
Coro, F
Kossl, M
AF Macias, S
Mora, EC
Coro, F
Kossl, M
TI Threshold minima and maxima in the behavioral audiograms of the bats
Artibeus jamaicensis and Eptesicus fuscus are not produced by cochlear
mechanics
SO HEARING RESEARCH
LA English
DT Article
DE distortion product otoacoustic emission; FM bats; pinna; cochlear
mechanics
ID LEAF-NOSED BATS; DISTORTION-PRODUCT; CAROLLIA-PERSPICILLATA;
PHYLLOSTOMUS-DISCOLOR; OTOACOUSTIC EMISSIONS; HEARING; ECHOLOCATION;
SENSITIVITY; ADAPTATIONS; EARS
AB Behavioral audiograins of Artibeus jamaicensis and Eptesicus fuscus are characterized by two threshold minima separated by a threshold maximum at 40 kHz, for A. jamaicensis, and 45 kHz, for E fuscus [Koay, G., Heffner, H.E., Heffner R.S., 1997. Audiogram of the big brown bat (Eptesicus fuscus). Hear. Res. 105, 202-210; Heffner, R.S., Koay, G., Heffner H.E., 2003. Hearing in American leaf-nosed bats. III: Artibeus jamaicensis. Hear. Res. 184, 113-122.]. To investigate whether these characteristics are due to cochlear properties, we recorded distortion product otoacooustic emissions (DPOAEs) and calculated DPOAE threshold curves. We found that in both species cochlear sensitivity, assessed by DPOAE recordings, does not show local threshold maxima. The DPOAE threshold curve calculated for A. jamaicensis reveals a broadly tuned minimum for frequencies between 20 and 50 kHz and the threshold curve of E fuscus shows a broad sensitive area for frequencies between 15 and 60 kHz. In none of the two species any pronounced threshold irregularities were found. The characteristic pattern of a threshold maximum followed by a minimum observed in behavioral studies seems to be shaped by transfer characteristics of the outer ear and/or neuronal processing in the ascending auditory pathway rather than by cochlear mechanics. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Havana, Dept Anim & Human Biol, Fac Biol, Havana 10400, Cuba.
Univ Havana, Dept Basic Format, Fac Psychol, Havana 10600, Cuba.
Univ Frankfurt, Inst Zool, D-60323 Frankfurt, Germany.
RP Macias, S (reprint author), Univ Havana, Dept Anim & Human Biol, Fac Biol, Calle 25,455 Entre J&I, Havana 10400, Cuba.
EM silvio@fbio.uh.cu
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NR 23
TC 4
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2006
VL 212
IS 1-2
BP 245
EP 250
DI 10.1016/j.heares.2005.12.004
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 022LT
UT WOS:000236058000023
PM 16434158
ER
PT J
AU Weaver, KE
Stevens, AA
AF Weaver, KE
Stevens, AA
TI Auditory gap detection in the early blind
SO HEARING RESEARCH
LA English
DT Article
DE early blindness; auditory temporal discrimination; aging
ID EARLY ACQUIRED BLINDNESS; YES-NO PROCEDURE; TEMPORAL GAPS; PSYCHOMETRIC
FUNCTIONS; CONGENITALLY BLIND; SIGHTED SUBJECTS; HEARING-LOSS; NOISE;
CORTEX; THRESHOLDS
AB For blind individuals, audition provides critical information for interacting with the environment. Individuals blinded early in life (EB) typically show enhanced auditory abilities relative to sighted controls as measured by tasks requiring complex discrimination, attention and memory. In contrast, few deficits have been reported on tasks involving auditory sensory thresholds (e.g., Yates, J.T., Johnson, R.M., Starz, W.J., 1972. Loudness perception of the blind. Audiology 11(5), 368-376; Starlinger, I., Niemeyer, W., 1981. Do the blind hear better? Investigations on auditory processing in congenital or early acquired blindness. I. Peripheral functions. Audiology 20(6), 503-509). A study of gap detection stands at odds with this distinction [Muchnik, C., Efrati, M., Nemeth, E., Malin, M., Hildesheimer, M., 1991. Central auditory skills in blind and sighted subjects. Scand. Audiol. 20(1), 19-23]. In the current investigation we re-examined gap detection abilities in the EB using a single-interval, yes/no method. A group of younger sighted control individuals (SCy) was included in the analysis in addition to EB and sighted age matched control individuals (SCm) in order to examine the effect of age on gap detection performance. Estimates of gap detection thresholds for EB subjects were nearly identical to SCm subjects and slightly poorer relative to the SCy subjects. These results suggest some limits on the extent of auditory temporal advantages in the EB. (c) 2005 Elsevier B.V. All rights reserved.
C1 Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA.
Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97239 USA.
RP Stevens, AA (reprint author), Oregon Hlth & Sci Univ, Dept Behav Neurosci, 3181 SW Sam Jackson Pk Rd,CR139, Portland, OR 97239 USA.
EM stevenal@ohsu.edu
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NR 40
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 1
EP 6
DI 10.1016/j.heares.2005.08.002
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500001
PM 16256283
ER
PT J
AU Sellick, PM
Robertson, D
Patuzzi, R
AF Sellick, PM
Robertson, D
Patuzzi, R
TI The effect of BAPTA and 4AP in scala media on transduction and cochlear
gain
SO HEARING RESEARCH
LA English
DT Article
DE cochlear amplifier; 4-amino-pyridine; BAPTA
ID GUINEA-PIG COCHLEA; OUTER HAIR-CELLS; MECHANICAL TRANSDUCTION; NEGATIVE
FEEDBACK; MAMMALIAN COCHLEA; NERVE; CHANNELS; MODEL; 4-AMINOPYRIDINE;
POTENTIALS
AB We have injected by iontophoresis 4-amino-pyridine, a K+ channel blocker and BAPTA, (a Ca++ chelator), into scala media of the first three turns of the guinea pig cochlea. We measured the reduction in outer hair cell (OHC) receptor current, as indicated by cochlear microphonic measured in scala media evoked by a 207 Hz tone, and compared this with the elevation of the cochlear action potential (CAP) threshold. We found that in the basal turn, for frequencies between 12 and 21 kHz, CAP threshold was elevated by about 30 dB, while in the second turn, at the 3 kHz place, the maximum elevation was 15 dB. In the third turn, iontophoresis of 4AP and BAPTA reduced CM by similar amounts to that in the basal and second turn, but caused negligible elevation of CAP threshold. We conclude that the gain of the cochlear amplifier is maximal for basal turn frequencies, is halved at 3 kHz, and is reduced to close to one for frequencies below I kHz (no active gain). The effect of 4AP and BAPTA on neural threshold and the receptor current represented by CM may be explained by their action on OHC transduction without the involvement of IHCs. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Western Australia, Sch Biomed & Chem Sci, Discipline Physiol, Auditory Lab, Nedlands, WA 6009, Australia.
RP Sellick, PM (reprint author), Univ Western Australia, Sch Biomed & Chem Sci, Discipline Physiol, Auditory Lab, Nedlands, WA 6009, Australia.
EM psellick@cyllene.uwa.edu.au
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NR 29
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 7
EP 15
DI 10.1016/j.heares.2005.05.016
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500002
PM 16343830
ER
PT J
AU Hu, BH
Henderson, D
Nicotera, TM
AF Hu, BH
Henderson, D
Nicotera, TM
TI Extremely rapid induction of outer hair cell apoptosis in the chinchilla
cochlea following exposure to impulse noise
SO HEARING RESEARCH
LA English
DT Article
DE apoptosis; cochlea; necrosis; impulse noise; outer hair cell; chinchilla
ID GUINEA-PIG COCHLEA; NEURONAL APOPTOSIS; INTENSE NOISE; BRAIN-INJURY;
HEARING-LOSS; CNS INJURY; DEATH; NECROSIS; MECHANISMS; GLUTAMATE
AB We have reported the presence of OHC apoptosis and necrosis in the organ of Corti following exposure to intense noise. The current study was designed to investigate the rapidity and the initial pattern of outer hair cell (OHC) death induced by exposure to impulse noise. Chinchillas were exposed to 75 pairs of impulse noise at 155 dB peak sound pressure level presented over a time period of 75 s. At 5 or 30 min after the noise exposure, the cochleae were examined for morphological and biological indicators of apoptosis and necrosis. In the cochleae collected within 5 min after the 75-s noise exposure, there were clear signs of nuclear condensation and cell body shrinkage, suggesting the presence of OHC apoptosis. Apoptotic OHCs were further detected by positive staining of TUNEL and caspase-3 assays. In contrast to the rapid development of nuclear condensation, appearance of nuclear swelling, a necrotic phenotype, appeared at 30 min after the noise exposure. The results of the study demonstrate that induction of OHC apoptosis after the noise exposure is an extremely rapid process. (c) 2005 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Dept Communicat Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
Roswell Pk Canc Inst, Dept Mol & Cellular Biophys, Buffalo, NY 14263 USA.
RP Hu, BH (reprint author), SUNY Buffalo, Dept Communicat Disorders & Sci, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM bhu@acsu.buffalo.edu; donaldhe@acsu.buffalo.edu;
thomas.nicotera@roswellpark.org
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NR 47
TC 50
Z9 56
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 16
EP 25
DI 10.1016/j.heares.2005.08.006
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500003
PM 16219436
ER
PT J
AU Choi, JY
Son, EJ
Kim, JL
Lee, JH
Park, HY
Kim, SH
Song, MH
Yoon, JH
AF Choi, JY
Son, EJ
Kim, JL
Lee, JH
Park, HY
Kim, SH
Song, MH
Yoon, JH
TI ENaC- and CFTR-dependent ion and fluid transport in human middle ear
epithelial cells
SO HEARING RESEARCH
LA English
DT Article
DE ion channel; fluid transport; sodium; chloride
ID AIRWAY SURFACE LIQUID; CYSTIC-FIBROSIS; SECRETORY DIFFERENTIATION; NA+
ABSORPTION; CL-SECRETION; CHANNELS; DISEASE; FAMILY; EXPRESSION;
CHILDREN
AB Ion channels, such as the epithelial sodium channel (ENaC), are essential for maintaining a fluid-free middle ear cavity by controlling periciliary fluid. Deviations from the normal volume or compositions of periciliary fluid are probably responsible for otitis media with effusion. To elucidate the physiologic roles of the ENaC and cystic fibrosis transmembrane conductance regulator (CFTR) in the middle ear mucosa, we compared the electrophysiological activity and protein expressions of ENaC and CFTR in normal human middle ear epithelial (NHMEE) cells with those in normal human nasal epithelial (NHNE) cells. We also evaluated the role of ENaC and CFTR in fluid transport by NHMEE cells. Short-circuit current (I-sc) was measured in cell monolayers by modified Ussing chambers. Immunoblotting was performed for ENaC and CFTR. In addition, transepithelial fluid transport was measured after loading 100 mu l of fluid onto the luminal cell surface. The amiloride-sensitive Isc in NHMEE cells was much larger than in NHNE cells, whereas the forskolin-induced Is, presumably mediated by CFTR, was significantly smaller in NHMEE cells. ENaC subunits alpha, beta, and gamma were all detected in NHMEE cells, and their expressions were stronger than those in NHNE cells. In comparison, CFTR was also detected in the middle ear mucosa, but at a lower expression level than in NHNE cells. NHMEE cells showed more amiloride-sensitive fluid absorption than NHNE cells. In contrast, fluid absorption was less sensitive to forskolin/IBMX in NHMEE cells than in NHNE cells, The ATP induced Cl- efflux and the amplitude of ATP-induced current in NHMEE cells was much larger than in NHNE cells. In the present study, we have demonstrated an enhanced amiloride-sensitive T, and fluid absorption in NHMEE cells, where the role of CFTR is limited. Our data also suggest that the ATP-induced Cl- channel could be an alternative Cl- channel to CFTR in NHMEE cells. (c) 2005 Elsevier B.V. All rights reserved.
C1 Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul 120752, South Korea.
Yonsei Univ, Coll Med, Airway Mucus Inst, Seoul 120752, South Korea.
Gacheon Med Sch, Dept Otorhinolaryngol, Inchon, South Korea.
RP Yoon, JH (reprint author), Yonsei Univ, Coll Med, Dept Otorhinolaryngol, 134 Shinchon Dong, Seoul 120752, South Korea.
EM jhyoon@yumc.yonsei.ac.kr
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NR 27
TC 12
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 26
EP 32
DI 10.1016/j.heares.2005.08.007
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500004
PM 16226002
ER
PT J
AU Stickney, GS
Loizou, PC
Mishra, LN
Assmann, PF
Shannon, RV
Opie, JM
AF Stickney, GS
Loizou, PC
Mishra, LN
Assmann, PF
Shannon, RV
Opie, JM
TI Effects of electrode design and configuration on channel interactions
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implants; channel interaction; speech perception
ID ELECTRICALLY STIMULATED COCHLEA; ROTATIONALLY SYMMETRICAL MODEL; SPEECH
RECOGNITION; AUDITORY-NERVE; NEURAL EXCITATION; IMPLANTS; PATTERNS;
SELECTIVITY; THRESHOLDS; RECORDINGS
AB A potential shortcoming of existing multichannel cochlear implants is electrical-field summation during simultaneous electrode stimulation. Electrical-field interactions can disrupt the stimulus waveform prior to neural activation. To test whether speech intelligibility can be degraded by electrical-field interaction, speech recognition performance and interaction were examined for three Clarion electrode arrays: the pre-curved, enhanced bipolar electrode array, the enhanced bipolar electrode with an electrode positioner, and the Hi-Focus electrode with a positioner. Channel interaction was measured by comparing stimulus detection thresholds for a probe signal in the presence of a sub-threshold perturbation signal as a function of the separation between the two simultaneously stimulated electrodes. Correct identification of vowels, consonants, and words in sentences was measured with two speech strategies: one which used simultaneous stimulation and another which used sequential stimulation. Speech recognition scores were correlated with measured electrical-field interaction for the strategy which used simultaneous stimulation but not the strategy which used sequential stimulation. Higher speech recognition scores with the simultaneous strategy were generally associated with lower levels of electrical-field interaction. Electrical-field interaction accounted for as much as 70% of the variance in speech recognition scores, suggesting that electrical-field interaction is a significant contributor to the variability found across patients who use simultaneous strategies. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Texas, Sch Human Dev, Richardson, TX 75083 USA.
Univ Texas, Sch Behav & Brain Sci, Richardson, TX 75083 USA.
Univ Texas, Dept Elect Engn, Richardson, TX 75083 USA.
House Ear Res Inst, Dept Auditory Implants & Percept, Los Angeles, CA 90057 USA.
Adv Bion Corp, Sylmar, CA 91342 USA.
RP Stickney, GS (reprint author), Univ Calif Irvine, Dept Otolaryngol, 364 Med Surg 2, Irvine, CA 92697 USA.
EM stickney@uci.edu
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NR 43
TC 33
Z9 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 33
EP 45
DI 10.1016/j.heares.2005.08.008
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500005
PM 16338109
ER
PT J
AU Hong, SH
Park, SK
Cho, YS
Lee, HS
Kim, KR
Kim, MG
Chung, WH
AF Hong, SH
Park, SK
Cho, YS
Lee, HS
Kim, KR
Kim, MG
Chung, WH
TI Gentamicin induced nitric oxide-related oxidative damages on vestibular
afferents in the guinea pig
SO HEARING RESEARCH
LA English
DT Article
DE gentamicin; ototoxicity; NOS; peroxynitrite
ID LIPOPOLYSACCHARIDE-INDUCED EXPRESSION; SYNTHASE INOS/NOS II; HAIR-CELLS;
SENSORY CELLS; AMINOGLYCOSIDE ANTIBIOTICS; IN-VIVO; GLUTAMATE; COCHLEA;
DEATH; EXPOSURE
AB Gentamicin is a well-known ototoxic aminoglycoside. However, the mechanism underlying this ototoxicity remains unclear. One of the mechanisms which may be responsible for this ototoxicity is excitotoxic damage to hair cells. The overstimulation of the N-methyl-D-aspartate (NMDA) receptors increases the production of nitric oxide (NO), which induces oxidative stress on hair cells. In order to determine the mechanism underlying this excitotoxicity, we treated guinea pigs with gentamicin by placing gentamicin (0.5 mg) pellets into a round window niche. After the sacrifice of the animals, which occurred at 3, 7 and 14 days after the treatment, the numbers of hair cells in the animals were counted with a scanning electron microscope. We then performed immunostaining using neuronal nitric oxide synthase (nNOS), inducible NOS (iNOS) and nitrotyrosine antibodies. The number of hair cells in the animals was found to decrease significantly after 7 days. nNOS and NOS expression levels were observed to have increased 3 days after treatment. Nitrotyrosine was expressed primarily at the calyceal afferents of the type 1 hair cells 3 days after treatment. Terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) staining revealed positive hair cells 3 days after treatment. Our results suggest that inner ear treatment with gentamicin may upregulate nNOS and iNOS to induce oxidative stress in the calyceal afferents of type I hair cells, via nitric oxide overproduction. (c) 2005 Elsevier B.V. All rights reserved.
C1 Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Otolaryngol & Head & Neck Surg, Seoul 135710, South Korea.
RP Chung, WH (reprint author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Otolaryngol & Head & Neck Surg, 50 Ilwon Dong, Seoul 135710, South Korea.
EM whchung@smc.samsung.co.kr
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NR 40
TC 26
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 46
EP 53
DI 10.1016/j.heares.2005.08.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500006
PM 16289993
ER
PT J
AU Guerin, A
Jeannes, RL
Bes, J
Faucon, G
Lorenzi, C
AF Guerin, A
Jeannes, RL
Bes, J
Faucon, G
Lorenzi, C
TI Evaluation of two computational models of amplitude modulation coding in
the inferior colliculus
SO HEARING RESEARCH
LA English
DT Article
DE amplitude modulation; cochlear nucleus; inferior colliculus; model
ID COCHLEAR NUCLEUS; TEMPORAL ENVELOPE; AUDITORY-CORTEX; COMPUTER-MODEL;
RESPONSES; SOUNDS; CAT; REPRESENTATION; MECHANISMS; NEURONS
AB Two computational models replicating amplitude-modulation encoding in the inferior colliculus (IC) are presented and compared. Neurons in this nucleus are modeled as point neurons using Mc Gregor equations, and receive depolarizing currents from action potentials delivered by stellate cells (chopper units) in the cochlear nucleus (CN). Stellate cells are modeled using modified Hodgkin-Huxley equations and receive inputs from a peripheral auditory model. The CN models of the two proposed architectures are characterized by an important dispersion of cellular characteristics, and therefore by various cellular best modulation frequencies (BMFs) ranging from 60 to 300 Hz. In contrast with the previous model proposed by [M.J. Hewitt, R. Meddis, A computer model of amplitude-modulation sensitivity of single units in the inferior colliculus, J. Acoust. Soc. Am. 95 (1994) 2145], each IC cell model receives convergent input from stellate cells with various BMFs. This approach assumes therefore minimal constraints on the model architecture and cell characteristics. The two models differ in terms of the neuronal structure of the IC, composed of 1 or 2 layers of point neurons acting as coincidence detectors. Each model is evaluated using two metrics: mean firing rate and modulation gain. Rate and temporal modulation transfer functions (r-MTFs and t-MTFs, respectively) are simulated and compared with physiological data. Simulations reveal that (i) an important dispersion of BMFs in the CN cells providing input to IC cells yields plausible IC cells responses to AM stimuli, (ii) the 2-layer IC structure yields the best approximation of IC responses measured in vivo. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Rennes 1, INSERM, U642, Lab Traitement Signal & Image, F-35042 Rennes, France.
Univ Paris 05, Inst Psychol, CNRS, UMR 8581,Lab Psychol Expt, F-75270 Paris 06, France.
RP Jeannes, RL (reprint author), Univ Rennes 1, INSERM, U642, Lab Traitement Signal & Image, F-35042 Rennes, France.
EM regine.le-bouquin-jeannes@univ-rennes1.fr
RI Lorenzi, Christian/F-5310-2012
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NR 23
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 54
EP 62
DI 10.1016/j.heares.2005.10.001
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500007
PM 16289669
ER
PT J
AU Sendowski, I
Raffin, F
Clarencon, D
AF Sendowski, I
Raffin, F
Clarencon, D
TI Spectrum of neural electrical activity in guinea pig cochlea: Effects of
anaesthesia regimen, body temperature and ambient noise
SO HEARING RESEARCH
LA English
DT Article
DE anaesthesia; cochlea; guinea pig; spontaneous activity; 900 Hz peak
ID KETAMINE-XYLAZINE ANESTHESIA; BRAIN-STEM RESPONSE; ROUND-WINDOW;
INFERIOR COLLICULUS; SURGICAL-PROCEDURES; AVERAGE SPECTRUM;
HYPERTHERMIA; TINNITUS; NERVE; PHARMACOLOGY
AB Spectral analysis of electric noise recorded from the round window of the cochlea is thought to represent the summed spontaneous activity of the auditory nerve. It has been postulated that it could provide a possible tinnitus index. Because experimental conditions could change this neural activity, the effect of anaesthesia regimen, body temperature and ambient noise on the spectrum of spontaneous neural noise (SNN) were investigated in guinea pig cochlea. SNN was studied in awake guinea pigs and after anaesthesia with pentobarbital (P), xylazine/ketamine (XK) or xylazine/tiletamine-zolazepam (XTZ). Body temperature varied gradually from 33 to 41 degrees C under XK regimen. In awake animals, broadband noise was generated with intensity varying from 0 to 50 dB. The SNN consisted in a broad peak at approximately 900 Hz. With ambient broadband noise, it increased exponentially with the sound level with no shift in frequency. Soon after anaesthetic induction, the lowest frequencies were constantly decreased, and gradually the 900 Hz peak either increased moderately (P) or dropped steeply (XTZ) or remained unchanged (XK). Peak frequency increased linearly with body temperature whereas the amplitude reached a maximum at around 39.5 degrees C. In conclusion, these data indicate that experimental conditions such as anaesthesia, regimen, body temperature and ambient noise modify the spontaneous neural outflow of the cochlea and must be taken into account when studying SNN. (c) 2005 Elsevier B.V. All rights reserved.
C1 CRSSA, Dept Radiobiol, F-38702 La Tronche, France.
RP Sendowski, I (reprint author), CRSSA, Dept Radiobiol, 24 Ave Maquis Gresivaudan,BP 87, F-38702 La Tronche, France.
EM lsendowski@crssa.net; Fraffin@crssa.net; Didierclarencon@crssa.net
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NR 55
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 63
EP 73
DI 10.1016/j.heares.2005.10.002
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500008
PM 16310327
ER
PT J
AU Fullgrabe, C
Berthommier, F
Lorenzi, C
AF Fullgrabe, C
Berthommier, F
Lorenzi, C
TI Masking release for consonant features in temporally fluctuating
background noise
SO HEARING RESEARCH
LA English
DT Article
DE speech perception; background noise; masking release; modulation
masking; 1st-order modulation; 2nd-order modulation
ID SPEECH-RECEPTION THRESHOLD; AMPLITUDE-MODULATED NOISE; NORMAL-HEARING
LISTENERS; COCHLEAR IMPLANT USERS; FREQUENCY-SELECTIVITY; INTERRUPTED
SPEECH; RECOGNITION; INTELLIGIBILITY; INTERFERENCE; MASKERS
AB Consonant identification was measured for normal-hearing listeners using Vowel-Consonant-Vowel stimuli that were either unprocessed or spectrally degraded to force listeners to use temporal-envelope cues. Stimuli were embedded in a steady state or fluctuating noise masker and presented at a fixed signal-to-noise ratio. Fluctuations in the maskers were obtained by applying sinusoidal modulation to: (i) the amplitude of the noise (1st-order SAM masker) or (ii) the modulation depth of a 1st-order SAM noise (2nd-order SAM masker). The frequencies of the amplitude variation f(m) and the depth variation f(m)' were systematically varied. Consistent with previous studies, identification scores obtained with unprocessed speech were highest in an 8-Hz, 1st-order SAM masker. Reception of voicing and manner also peaked around f(m) = 8 Hz, while the reception of place of articulation was maximal at a higher frequency (f(m) = 32 Hz). When 2nd-order SAM maskers were used, identification scores and received information for each consonant feature were found to be independent of f(m)'. They decreased progressively with increasing carrier modulation frequency f(m) and ranged between those obtained with the steady state and the 1st-order SAM maskers. Finally, the results obtained with spectrally degraded speech were similar across all types of maskers, although an 8% improvement in the reception of voicing was observed for modulated maskers with fm < 64 Hz compared to the steady-state masker. These data provide additional evidence that listeners take advantage of temporal minima in fluctuating background noises, and suggest that: (i) minima of different durations are required for an optimal reception of the three consonant features and (ii) complex (i.e., 2nd-order) envelope fluctuations in background noise do not degrade speech identification by interfering with speech-envelope processing. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Paris 05, Inst Psychol, Expt Psychol Lab, CNRS,UMR 8581, F-92774 Boulogne, France.
Inst Natl Polytech Grenoble, Inst Commun Parlee, CNRS, UPRESA 5009, F-38031 Grenoble, France.
RP Fullgrabe, C (reprint author), Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England.
EM c.fullgrabe@psychol.cam.ac.uk
RI Imhof, Margarete/F-8471-2011; Lorenzi, Christian/F-5310-2012; Fullgrabe,
Christian/I-6331-2012
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NR 49
TC 55
Z9 59
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 74
EP 84
DI 10.1016/j.heares.2005.09.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500009
PM 16289579
ER
PT J
AU Han, WJ
Shi, XR
Nuttall, AL
AF Han, WJ
Shi, XR
Nuttall, AL
TI AIF and endoG translocation in noise exposure induced hair cell death
SO HEARING RESEARCH
LA English
DT Article
DE noise exposure; apoptosis; apoptosis inducing factor; endonuclease G;
caspase; mitochondria; guinea pig
ID ENDONUCLEASE-G; INDUCED APOPTOSIS; ACTIVATION; MICE; MITOCHONDRIA;
NECROSIS; PATHWAY; HEARING
AB Activation of caspases is a key element in the apoptotic process. However, mitochondria also play an important role via the release of proapoptotic proteins. This study investigated the roles of mitochondria-related apoptosis inducing factor (AIF) and endonuclease G (endoG), mitochondrion-specific nucleases, as well as caspase-3, an important mediator of apoptosis, in noise exposure induced hair cell death. Guinea pigs were exposed for 4 h/day to broadband noise at 122 dB SPL for 2 days. After the noise exposure, the cochleae were examined for the activity of caspase-3 with carboxyfluorescein-labeled fluoromethyl ketone (FMK)-peptide inhibitors. The cochleae were further examined for AIF and endoG translocation from the mitochondria by. immunohistochemistry. Noise exposure triggered activation of caspase-3 in apoptotic hair cells. In the normal organ of Corti, AIF and endoG were co-localized to the mitochondria. After noise exposure, AIF translocated into the nuclei of apoptotic and necrotic hair cells. The translocation of endoG from mitochondria into the nucleus was also found in apoptotic OHCs. These findings indicate that mitochondria-released proapoptotic proteins, AIF and endoG, are important factors in a noise-induced hair cell death pathway. (c) 2005 Published by Elsevier B.V.
C1 Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97290 USA.
Chinese Peoples Liberat Army Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100853, Peoples R China.
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
RP Nuttall, AL (reprint author), Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Rd,NRC04, Portland, OR 97290 USA.
EM nuttall@ohsu.edu
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NR 36
TC 25
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 85
EP 95
DI 10.1016/j.heares.2005.10.004
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500010
PM 16309861
ER
PT J
AU Phillips, DP
Carmichael, ME
Hall, SE
AF Phillips, DP
Carmichael, ME
Hall, SE
TI Interaction in the perceptual processing of interaural time and level
differences
SO HEARING RESEARCH
LA English
DT Article
DE interaural level difference; interaural time difference; selective
adaptation; auditory lateralization; opponent process model
ID SUPERIOR OLIVARY COMPLEX; PRIMARY AUDITORY-CORTEX; LOW-FREQUENCY
NEURONS; SOUND-LOCALIZATION; BINAURAL INTERACTION; INFERIOR COLLICULUS;
CAT; SENSITIVITY; LOCATION; INTENSITY
AB Phillips and Hall [Psychophysical evidence for adaptation of central auditory processors for interaural differences in time and level, Hear. Res., 202 (2005) 188-199.] recently described the frequency-specific, selective adaptation of perceptual channels for interaural differences in level (ILD) and time (ITD). Psychometric functions for laterality based on ITD or ILD were obtained before and after exposure to adaptor tones of two frequencies presented alternately and highly lateralized to opposite sides. Following adaptation, points of perceived centrality (PPCs) were displaced towards the sides of the adaptor tones, and in opposite directions for the two frequencies. That is, laterality judgements showed a shift away from the adapted side, particularly for test cue values near the middle of the range. These data were congruent with a two-channel, opponent-process model of sound laterality coding. The present study used the same general paradigm to explore the independence of perceptual ITD and ILD processing. Psychometric functions for laterality based on ITD or ILD were obtained for each of two frequencies concurrently, before and after exposure to adaptor tones lateralized using the complementary cue. Once again, PPCs derived from the psychometric functions were displaced towards the sides of the adaptor tones, consistent with an opponent-process account of sound laterality coding. The size of the adaptation effect was at least as great as that described in the earlier study. Thus, a quarter cycle ITD adapting stimulus effected a 3 dB shift in the mean ILD-based PPC, and a 12 dB ILD adapting stimulus effected a 100 mu s shift in the mean ITD-based PPC. These data offer new evidence concerning interaction in the processing of ITDs and ILDs. (c) 2005 Elsevier B.V. All rights reserved.
C1 Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada.
RP Phillips, DP (reprint author), Dalhousie Univ, Dept Psychol, Hearing Res Lab, 1355 Oxford St, Halifax, NS B3H 4J1, Canada.
EM dennis.phillips@dal.ca
RI Phillips, Dennis/A-6496-2011
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NR 36
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 96
EP 102
DI 10.1016/j.heares.2005.10.005
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500011
PM 16309863
ER
PT J
AU Frisina, ST
Mapes, F
Kim, S
Frisina, DR
Frisina, RD
AF Frisina, ST
Mapes, F
Kim, S
Frisina, DR
Frisina, RD
TI Characterization of hearing loss in aged type II diabetics
SO HEARING RESEARCH
LA English
DT Article
DE presbycusis; age-related hearing loss; cochlea; auditory system; aging;
geriatric; metabolic; insulin; type II diabetes
ID PROTEIN-KINASE-C; GUINEA-PIG COCHLEA; NITRIC-OXIDE; INFERIOR COLLICULUS;
INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; IV COLLAGEN; IN-VIVO;
NEURODEGENERATIVE DISORDERS; ADVANCED GLYCOSYLATION
AB Presbycusis - age-related hearing loss - is the number one communicative disorder and a significant chronic medical condition of the aged. Little is known about how type II diabetes, another prevalent age-related medical condition, and presbyeusis interact. The present investigation aimed to comprehensively characterize the nature of hearing impairment in aged type II diabetics. Hearing tests measuring both peripheral (cochlea) and central (brainstem and cortex) auditory processing were utilized. The majority of differences between the hearing abilities of the aged diabetics and their age-matched controls were found in measures of inner ear function. For example, large differences were found in pure-tone audiograms, wideband noise and speech reception thresholds, and otoacoustic emissions. The greatest deficits tended to be at low frequencies. In addition, there was a strong tendency for diabetes to affect the right ear more than the left. One possible interpretation is that as one develops presbycusis, the right ear advantage is lost, and this decline is accelerated by diabetes. In contrast, auditory processing tests that measure both peripheral and central processing showed fewer declines between the elderly diabetics and the control group. Consequences of elevated blood sugar levels as possible underlying physiological mechanisms for the hearing loss are discussed. (c) 2005 Published by Elsevier B.V.
C1 Rochester Inst Technol, Natl Tech Inst Deaf, Int Ctr Hearing & Speech Res, Rochester, NY 14623 USA.
Univ Rochester, Sch Med & Dent, Dept Otolaryngol, Rochester, NY 14642 USA.
Univ Rochester, Sch Med & Dent, Dept Anat & Neurobiol, Rochester, NY 14642 USA.
Univ Rochester, Sch Med & Dent, Dept Biomed Engn, Rochester, NY 14642 USA.
Daegu Fatima Hosp, Dept Otorhinolaryngol, Taegu 701600, South Korea.
RP Frisina, RD (reprint author), Rochester Inst Technol, Natl Tech Inst Deaf, Int Ctr Hearing & Speech Res, Rochester, NY 14623 USA.
EM rdf@cq.ent.rochester.edu
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NR 85
TC 49
Z9 57
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 103
EP 113
DI 10.1016/j.heares.2005.09.002
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500012
PM 16309862
ER
PT J
AU Bortone, DS
Mitchell, K
Manis, PB
AF Bortone, DS
Mitchell, K
Manis, PB
TI Developmental time course of potassium channel expression in the rat
cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE auditory; ion channel; RT-PCR; mRNA; QPCR
ID KV4.2 MESSENGER-RNA; DIFFERENTIAL EXPRESSION; BRAIN-STEM;
ELECTRICAL-PROPERTIES; AUDITORY NEURONS; K+ CURRENT; CURRENTS; CELLS;
MOUSE; MICE
AB Voltage gated potassium channels play critical roles in determining the responses of auditory brainstem neurons to acoustic stimuli. In the present study, we examined the developmental expression of potassium channels in rat cochlear nucleus. Quantitative RT-PCR revealed that K(v)1.1, K(v)1.2 and K(v)3.1 showed a monotonic increase in mRNA levels from postnatal days 3-28 (P3-P28), after which mRNA level was relatively constant until P56. In contrast, K(v)4.2 mRNA levels were lower on average by a factor of 2 after P28 than before P28. Relative to K(v)1.1, K(v)3.1 and K(v)1.2 mRNA were more abundant before P10 and less abundant thereafter. To address the relationship between message and protein levels, we performed semi-quantitative Western blotting for K(v)1.2. The message for K(v)1.2 increased earlier in development than the protein levels. Immunocytochemistry revealed a broad expression of K(v)1.1 and K(v)1.2 in the VCN. Staining intensity increased from 7-28 days postnatal. K(v)1.2 immunostaining was less variable across cells than Kv1.1 staining. We conclude that maturation of potassium channel expression in the rat cochlear nucleus continues until at least 4 weeks postnatal. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA.
RP Manis, PB (reprint author), Univ N Carolina, Dept Otolaryngol Head & Neck Surg, 1123 Bioinformat Bldg,CB 7070,130 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM pmanis@med.unc.edu
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NR 45
TC 19
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2006
VL 211
IS 1-2
BP 114
EP 125
DI 10.1016/j.heares.2005.10.012
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 011KQ
UT WOS:000235267500013
PM 16337757
ER
PT J
AU Li, JP
Kania, R
Lecain, E
Ar, A
Sauvaget, E
Huy, PTB
Herman, P
AF Li, JP
Kania, R
Lecain, E
Ar, A
Sauvaget, E
Huy, PTB
Herman, P
TI In vivo demonstration of the absorptive function of the middle ear
epithelium
SO HEARING RESEARCH
LA English
DT Article
DE absorptive function; sodium flux; middle ear epithelium; in vivo
ID ION-TRANSPORT; OTITIS-MEDIA; BIOELECTRIC PROPERTIES; SODIUM-TRANSPORT;
CL-SECRETION; EXPRESSION; CLEARANCE; PRESSURE; CHANNELS; FLUID
AB The present study investigated in vivo fluid and ion transport across the middle ear epithelium. The tympanic membrane of rats was punctured under general anesthesia. A capillary tube was fitted to the external auditory canal and the bulla filled with various solutions. Middle ear (ME) fluid volume variations were then measured at constant pressure.
When saline was used, a linear decrease of fluid volume was apparent. Replacement of sodium with a non-permeable cation (N-methyl-D-glucamin) reduced the absorption rate from 0.065 +/- 0.008 to 0.019 +/- 0.003 mu l/min (P < 0.05, n = 6). Similarly, amiloride (10(-3) M), a sodium channel antagonist, reduced the absorption rate to 0.027 +/- 0.006 mu l/min (P < 0.05, n = 6). Net absorption was abolished when chloride was substituted with gluconate: -0.008 +/- 0.004 mu l/min (P < 0.02, n = 6), which might have been related (i) to the role of chloride as a diffusible anion through the paracellular pathway, or (ii) to the secretion of chloride through apical channels. However in this condition, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, a chloride channel blocker, did not affect the rate of fluid exchange -0.008 +/- 0.007 mu l/min (P = 0.75, n = 6).
This model provides the first in vivo evidence for the absorptive function of the ME. Fluid introduced into the ME cavity disappears due to active transport through the mucosa. This process is sodium-dependent and can be hindered by high concentration of amiloride. The rate of absorption is high enough to allow total clearance of fluid from the cavity of the middle ear within 13 h. This process might play a role in the maintaining a fluid-free and gas-filled middle ear cavity. (c) 2005 Published by Elsevier B.V.
C1 Hop Lariboisiere, Serv ORL, F-75475 Paris, France.
Shanghai Med Univ, Ren Ji Hosp, Dept Otolaryngol Head & Neck Surg, Shanghai 200001, Peoples R China.
APHP, Fac Lariboisiere St Louis, Lab Otol Expt, LNRS 7060,CNRS, Paris, France.
Tel Aviv Univ, Fac Life Sci, Dept Zool, IL-69978 Tel Aviv, Israel.
RP Herman, P (reprint author), Hop Lariboisiere, Serv ORL, 2 Rue Ambroise Pare, F-75475 Paris, France.
EM philippe.herman@lrb.ap-hop-paris.fr
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NR 26
TC 11
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 1
EP 8
DI 10.1016/j.heares.2005.04.011
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500001
PM 16256284
ER
PT J
AU Takahashi, H
Nakao, M
Kaga, K
AF Takahashi, H
Nakao, M
Kaga, K
TI Interfield differences in intensity and frequency representation of
evoked potentials in rat auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE auditory cortex; functional organization; auditory evoked potential;
surface microelectrode array; rat
ID POSTERIOR FIELD; SOUND INTENSITY; DISTRIBUTED REPRESENTATION;
AMPLITUDE-MODULATION; INFERIOR COLLICULUS; FUNCTIONAL-ANATOMY; MAMMALIAN
COCHLEA; CEREBRAL-CORTEX; STRIATE CORTEX; SINGLE NEURONS
AB Existing studies have demonstrated interfield differences in functional organizations and neuronal responsive properties at a single neuron level in the auditory cortex, suggesting complicated encoding of sound frequency and intensity. The objective of present work is, by characterizing cortical auditory evoked potentials (AEPs), to bridge neural characteristics between a single neuron and field levels and to identify the interfield differences in the auditory cortex specifically in terms of spatial representation, which will be useful in guiding future unit studies. The AEP mapping found that each of auditory fields, which could be identified by a different tonotopic representation, showed interfield differences in an intensity-dependent spatial change, amplitude, latency, and amplitude-SPL (sound pressure level) function. These results also showed that many aspects of cortical representation were based on the cochlear properties, yet some were inconsistent. The intensity-dependent shift of activation in AI paralleled the tonotopic axis, which was similar to the place code in cochlea, while the shift in AAF and VAF did not parallel. Nevertheless, the amplitude-SPL function suggested that an underlying mechanism of all these shifts can be a compressive nonlinearity to CF tone, which is possibly formed in the cochlea and still preserved in the cortex. These results suggest that each field modifies the representation to handle a different aspect of sound information, which can be better analyzed than the cochlear representation. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Tokyo, Grad Sch Engn, Dept Engn Synth, Bunkyo Ku, Tokyo 1138656, Japan.
Univ Tokyo, Grad Sch Informat Sci & Technol, Dept Mechanoinformat, Bunkyo Ku, Tokyo 1138656, Japan.
Univ Tokyo, Grad Sch Med, Dept Otolaryngol & Head & Neck Surg, Bunkyo Ku, Tokyo 1138656, Japan.
RP Takahashi, H (reprint author), Univ Tokyo, Grad Sch Engn, Dept Engn Synth, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan.
EM hiro@hnl.u-tokyo.ac.jp
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NR 50
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 9
EP 23
DI 10.1016/j.heares.2005.05.014
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500002
PM 16213681
ER
PT J
AU Zeftawi, MS
AF Zeftawi, MS
TI MMN to natural Arabic CV syllables: 2-cross language study
SO HEARING RESEARCH
LA English
DT Article
DE MMN; Arabic; phonetic; speech processing
ID MISMATCH NEGATIVITY MMN; HUMAN AUDITORY-CORTEX; SPEECH SOUNDS; HUMAN
BRAIN; COGNITIVE NEUROSCIENCE; MEMORY TRACES; REPRESENTATION;
PERCEPTION; POTENTIALS; PLASTICITY
AB Mismatch negativity response parameters; latency, amplitude, and duration - to natural Arabic and natural English CV syllables - were obtained from normal-hearing adult Egyptians, in two experiments. In the first experiment, MMN was obtained in response to English CV syllable paradigms (Ba-Wa) and (Ga-Da) differing in formant duration and start of third formant, respectively. In the second experiment, MMN response for Arabic paradigm (Baa-Waa), English paradigm (Ba-Wa), and for Arabic-English paradigm (Waa-Wa) was obtained. Results revealed that the three levels of speech representation; acoustic, phonetic and phonologic could be probed preattentatively by MMN. The acoustic properties of speech signal are processed earlier than the phonetic and phonologic properties. (c) 2005 Elsevier B.V. All rights reserved.
C1 Mansoura Gen Hosp, Audiol Unit, Mansoura, Egypt.
RP Zeftawi, MS (reprint author), Mansoura Gen Hosp, Audiol Unit, Mansoura, Egypt.
EM m.samir@medscape.com
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NR 43
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 24
EP 29
DI 10.1016/j.heares.2005.06.012
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500003
PM 16055287
ER
PT J
AU Lyzenga, J
Carlyon, RP
Moore, BCJ
AF Lyzenga, J
Carlyon, RP
Moore, BCJ
TI Dynamic aspects of the continuity illusion: Perception of level and of
the depth, rate, and phase of modulation
SO HEARING RESEARCH
LA English
DT Article
DE modulation rate; modulation depth; modulation phase; continuity illusion
ID FREQUENCY-MODULATION; AMPLITUDE-MODULATION; PERCEIVED CONTINUITY;
DISCRIMINATION; TONES; CARRIERS; PITCH; COHERENCE; SOUNDS; GLIDES
AB The perception of modulation of a tone interrupted by a noise burst was investigated. The tone and its modulation were perceived as continuing through the noise. In experiment 1, subjects rated the similarity of an uninterrupted tone and a tone interrupted by noise, in terms of the perceived level and modulation depth of the sinusoidal carrier. The values of these parameters in the central portion of the uninterrupted tone were systematically varied. Both amplitude and frequency modulation (AM and FM) were used. The results indicated that the perceived level and modulation depth of the carrier did not change greatly during the noise burst. When the modulation rate differed before and after the noise burst, the modulation-rate transition was perceived to occur near the end of the noise burst for the FM stimuli. Hence, for these stimuli, the continuity illusion appears to be dominated by the portion of the tone before, rather than after, the interruption. Results for the AM stimuli showed a non-significant trend in the same direction. Experiment 2 used forced-choice tasks to evaluate the ability to detect a change in the ongoing phase of AM and FM following interruption by a noise burst. The results confirmed earlier findings for FM tones, and extended them to AM tones, showing that listeners lost track of the phase of the modulation, even though the modulation was perceived as continuous. (c) 2005 Elsevier B.V. All rights reserved.
C1 MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England.
Univ Cambridge, Dept Expt Psychol, Cambridge CB3 3EB, England.
RP Lyzenga, J (reprint author), Vrije Univ Amsterdam, Med Ctr, Dept ENT Audiol, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
EM j.lyzenga@vume.nl
RI Carlyon, Robert/A-5387-2010; Moore, Brian/I-5541-2012
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NR 30
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 30
EP 41
DI 10.1016/j.heares.2005.07.002
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500004
PM 16125887
ER
PT J
AU Simpson, A
McDermott, HJ
Dowell, RC
AF Simpson, A
McDermott, HJ
Dowell, RC
TI Benefits of audibility for listeners with severe high-frequency hearing
loss
SO HEARING RESEARCH
LA English
DT Article
DE high-frequency hearing impairment; hearing aids; cochlear dead regions
ID ARTICULATION INDEX PREDICTIONS; COCHLEAR DEAD REGIONS; IMPAIRED
LISTENERS; PERCEPTION; SPEECH; MODEL
AB A consonant identification test was carried out with 10 hearing-impaired listeners under various low-pass filter conditions. Subjects were also tested for cochlear dead regions with the TEN test. All subjects had moderate-to-severe high-frequency hearing losses. Consonant recognition was tested under conditions in which the speech signals were highly audible to subjects for frequencies up to the low-pass filter cut-off. Extensive dead regions were found for one subject with the TEN test. The remaining subjects may have had dead regions above 3 kHz, because of the severity of their hearing losses, but these could not be demonstrated with the TEN test. Average consonant scores for the subject group improved significantly (p < 0.05) with increasing audibility of high-frequency components of the speech signal. There were no cases of speech perception being reduced with increasing bandwidth. Nine of the subjects showed improvements in scores with increasing audibility, whereas the remaining subject showed little change in scores. For this subject, speech perception results were consistent with the TEN test findings. In general, the results suggest that listeners with severe high-frequency losses are often able to make some use of high-frequency speech cues if these cues can be made audible. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Cooperat Res Ctr Cochelar Implant & Hearing Aid I, Melbourne, Vic 3002, Australia.
Univ Melbourne, Bion Ear Inst, Melbourne, Vic 3002, Australia.
Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
RP Simpson, A (reprint author), Univ Melbourne, Cooperat Res Ctr Cochelar Implant & Hearing Aid I, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM asimpson@bionicear.org
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NR 27
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 42
EP 52
DI 10.1016/j.heares.2005.07.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500005
PM 16137848
ER
PT J
AU Songer, JE
Rosowski, JJ
AF Songer, JE
Rosowski, JJ
TI The effect of superior canal dehiscence on cochlear potential in
response to air-conducted stimuli in chinchilla
SO HEARING RESEARCH
LA English
DT Article
DE superior canal dehiscence; third-window hypothesis; auditory mechanisms
ID HEARING-LOSS; MECHANISMS; EARPHONES; VERTIGO; MODEL
AB A superior semicircular canal dehiscence (SCD) is a break or hole in the bony wall of the superior semicircular canal. Patients with SCD syndrome present with a variety of symptoms: some with vestibular symptoms, others with auditory symptoms (including low-frequency conductive hearing loss) and yet others with both. We are interested in whether or not mechanically altering the superior canal by introducing a dehiscence is sufficient to cause the low-frequency conductive hearing loss associated with SCD syndrome. We evaluated the effect of a surgically introduced dehiscence on auditory responses to air-conducted (AC) stimuli in 11 chinchilla ears. Cochlear potential (CP) was recorded at the round-window before and after a dehiscence was introduced. In each ear, a decrease in CP in response to low frequency (<2 kHz) sound stimuli was observed after the introduction of the dehiscence. The dehiscence was then patched with cyanoacrylate glue leading to a reversal of the dehiscence-induced changes in CP. The reversible decrease in auditory sensitivity observed in chinchilla is consistent with the elevated AC thresholds observed in patients with SCD. According to the 'third-window' hypothesis the SCD shunts sound-induced stapes velocity away from the cochlea, resulting in decreased auditory sensitivity to AC sounds. The data collected in this study are consistent with predictions of this hypothesis. (c) 2005 Elsevier B.V. All rights reserved.
C1 Massachusetts Eye & Ear Infirm, Eaton Peabody Lab Auditory Physiol, Boston, MA 02114 USA.
Harvard Univ, MIT, Cambridge, MA 02138 USA.
Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Songer, JE (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab Auditory Physiol, 243 Charles St, Boston, MA 02114 USA.
EM jocelyns@mit.edu; John_Rosowski@meei.harvard.edu
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NR 22
TC 34
Z9 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 53
EP 62
DI 10.1016/j.heares.2005.07.003
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500006
PM 16150562
ER
PT J
AU Brimijoin, WO
O'Neill, WE
AF Brimijoin, WO
O'Neill, WE
TI On the prediction of sweep rate and directional selectivity for FM
sounds from two-tone interactions in the inferior colliculus
SO HEARING RESEARCH
LA English
DT Article
DE auditory midbrain; frequency modulation; spectrotemporal receptive
field; mustached bat; neural delay lines; FM models; temporal processing
ID PRIMARY AUDITORY-CORTEX; FREQUENCY-MODULATED STIMULI;
COMBINATION-SENSITIVE NEURONS; MEDIAL GENICULATE-BODY; ECHO-LOCATING
BATS; MOUSTACHED BAT; SPECTRAL INTEGRATION; RESPONSE PROPERTIES;
COCHLEAR NUCLEUS; SINGLE UNITS
AB Two-tone stimuli have traditionally been used to reveal regions of inhibition in auditory spectral receptive fields, particularly for neurons with low spontaneous rates. These techniques reveal how different frequencies excite or suppress the response to an excitatory frequency of a cell, but have often been assessed at a fixed masker-probe time interval. We used a variation of this methodology to determine whether two-tone spectrotemporal interactions can account for rate-dependent directional selectivity for frequency modulations (FM) in the mustached bat inferior colliculus (IC). First, we quantified the response to upward and downward sweeping, linear, fixed-bandwidth FM tones centered at a unit's characteristic frequency (CF) at 6 sweep durations ranging from 2 to 64 ins. Then, to examine how responses to instantaneous frequencies contained within the sweeps might interact in time, we varied the frequency and relative onset of a brief (4 ms) "conditioner" tone paired with a fixed 4-ms CF probe tone. We constructed "conditioned response areas" (CRA) depicting regions of suppression and facilitation of the probe tone caused by the conditioning tone. We classified the CRAs as predominantly excitatory (40.9%), inhibitory (22.7%), or mixed (36.4%). To generate FM response predictions, the CRAs were multiplied with spectrograms of the same sweeps used to assess response to FM. The predictions of FM rate and directionality were accurate by our criteria in approximately 20% of units. Conversely, the CRAs from the remaining units failed to predict FM responses as accurately, suggesting that most IC units respond differently to FM sweeps than they do to tone-pairs matched to the instantaneous frequencies contained in those sweeps. The implications of these results for models of FM directionality are discussed. (c) 2005 Elsevier B.V. All rights reserved.
C1 Ctr Navigat & Commun Sci, Rochester, NY 14642 USA.
Univ Rochester, Dept Brain & Cognit Sci, Rochester, NY 14627 USA.
Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
RP O'Neill, WE (reprint author), Ctr Navigat & Commun Sci, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM william_oneill@urmc.rochester.edu
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NR 46
TC 15
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 63
EP 79
DI 10.1016/j.heares.2005.07.005
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500007
PM 16263230
ER
PT J
AU Gazzaz, B
Weil, D
Rais, L
Akhyat, O
Azeddoug, H
Nadifi, S
AF Gazzaz, B
Weil, D
Rais, L
Akhyat, O
Azeddoug, H
Nadifi, S
TI Autosomal recessive and sporadic deafness in Morocco: High frequency of
the 35delG GJB2 mutation and absence of the 342-kb GJB6 variant
SO HEARING RESEARCH
LA English
DT Article
DE deafness; ARNSHL; sporadic; GJB2 and GJB6; Morocco
ID CONNEXIN 26 GENE; SENSORINEURAL HEARING-LOSS; PRELINGUAL DEAFNESS;
CARRIER FREQUENCY; POPULATION; PREVALENCE; IMPAIRMENT; FORM
AB Deafness is a heterogeneous disorder showing different pattern of inheritance and involving a multitude of different genes. Mutations in the gene, GJB2 Gap junction type 1), encoding the gap junction protein connexin-26 on chromosome 13q11 may be responsible for up 50% of autosomal recessive nonsyndromic hearing loss cases (ARNSHL), and for 15-30% of sporadic cases. However, a large proportion (10-42%) of patients with GJB2 has only one GJB2 mutant allele. Recent reports have suggested that a 342-kb deletion truncating the GJB6 gene (encoding connexin-30), was associated with ARNSHL through either homozygous deletion of Cx30, or digenic inheritance of a Cx30 deletion and a Cx26 mutation in trans. Because mutations in Connexin-26 (Cx26) play an important role in ARNSHL and that distribution pattern of GJB2 variants differs considerably among ethnic groups, our objective was to find out the significance of Cx26 mutations in Moroccan families who had hereditary and sporadic deafness. One hundred and sixteen families with congenital deafness (including 38 multiplex families, and 78 families with sporadic cases) were included. Results show that the prevalence of the 35delG mutation is 31.58% in the family cases and 20.51% in the sporadic cases. Further screening for other GJB2 variants demonstrated the absence of other mutations; none of these families had mutations in exon 1 of GJB2 or the 342-kb deletion of GJB6. Thus, screening of the 35delG in the GJB2 gene should facilitate routinely used diagnostic for genetic counselling in Morocco. (c) 2005 Elsevier B.V. All rights reserved.
C1 Fac Med & Pharm, Med Genet Lab, Casablanca, Morocco.
Fac Sci Ain Chock, Mol Biol Lab, Casablanca, Morocco.
CHU Ibnou Rochd, Dept Ophthalmol, Casablanca, Morocco.
Inst Pasteur, Unite Genet Deficits Sensoriels, Paris, France.
Fac Sci Ibn Zohr, Mol Biol Lab, Agadir, Morocco.
RP Nadifi, S (reprint author), Fac Med & Pharm, Med Genet Lab, Casablanca, Morocco.
EM s.nadifi@caramail.com
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NR 38
TC 21
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 80
EP 84
DI 10.1016/j.heares.2005.08.001
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500008
PM 16243461
ER
PT J
AU Braun, M
Chaloupka, V
AF Braun, M
Chaloupka, V
TI Carbamazepine induced pitch shift and octave space representation
SO HEARING RESEARCH
LA English
DT Article
DE carbamazepine; medial geniculate nucleus; inferior colliculus; octave
mapping; fundamental frequeney fo; pitch
ID MEDIAL GENICULATE-BODY; CELLS IN-VITRO; ABSOLUTE-PITCH; INFERIOR
COLLICULUS; LAMINAR STRUCTURE; ACTION-POTENTIALS; PERCEPTION;
IDENTIFICATION; TRIMIPRAMINE; INHIBITION
AB Octave-circular pitch perception, the repetition of pitch scale qualities when surpassing the octave interval, has been observed in behavioral data from humans and monkeys, but the underlying anatomy and physiology is still unknown. Here we analyze octave circularity in a concert pianist with absolute pitch, both under medication with the neurotropic drug carbamazepine (CBZ) and without medication. Analysis of 4619 responses in a pitch identification task revealed an internal tone-scale representation, based on the norm-tone scale re A4 = 440 Hz, with an octave-circular pattern of strongly and weakly represented tones. CBZ caused a global down-shift of pitch (ca. 1 semitone at 500 Hz), but no down-shift of the octave-circular pattern of tone characteristics. This pattern was similar in the six tested octave ranges (32.7-2093 Hz), both under the control and the CBZ condition. Pattern repetition always occurred at octave intervals and did not reflect the stretched octaves of piano tuning. The results indicate that CBZ influences pitch detection peripheral of an octave-circular pitch representation. Thus they support previous evidence for pitch detection in the auditory midbrain and for octave-circular pitch mapping in the auditory thalamus. (c) 2005 Elsevier B.V. All rights reserved.
C1 Neurosci Music, S-67195 Klassbol, Sweden.
Univ Washington, Dept Phys, Seattle, WA 98195 USA.
Univ Washington, Sch Music, Seattle, WA 98195 USA.
RP Braun, M (reprint author), Neurosci Music, Gansbyn 14, S-67195 Klassbol, Sweden.
EM nombraun@telia.com
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NR 45
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 85
EP 92
DI 10.1016/j.heares.2005.05.015
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500009
PM 16181754
ER
PT J
AU Shwinska-Kowalska, M
Rzadzinska, A
Rajkowska, E
Malczyk, M
AF Shwinska-Kowalska, M
Rzadzinska, A
Rajkowska, E
Malczyk, M
TI Expression of bFGF and NGF and their receptors in chick's auditory organ
following overexposure to noise
SO HEARING RESEARCH
LA English
DT Article
DE mRNA; hair cells; regeneration; immunohistochemistry; polyclonal
antibody anti-CRF; polyclonal anti-tyrosine kinase antibody
ID FIBROBLAST-GROWTH-FACTOR; HAIR CELL REGENERATION; AVIAN INNER-EAR;
ACOUSTIC TRAUMA; NEUROTROPHIC FACTOR; MESSENGER-RNAS; IN-VITRO;
POTENTIAL ROLE; RAT COCHLEA; BASIC FGF
AB Growth factors are known to activate signaling cascades for DNA replication; they participate in the regulation of cell differentiation and are required as positive signals for cell survival. Thus, many of them may be regarded as potential candidates stimulating regeneration processes in the inner ear. We analyzed the expression of basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) and their receptor (bFGFR and NGFR)-like immunoreactivity in chick basilar papillae, along with bFGF and NGF mRNA expression. The evaluation was made 1 and 5 days after exposure to wide-band noise with two increasing levels of acoustic energy.
For both factors, the immunoreactivity was shown predominantly in the middle part of basilar papilla, in noise-exposed, but not control birds. It was localized in the cytoplasm of hair cells, nuclei of supporting cells and cytoplasm of ganglion cells. Strong immunoreactivity of bFGFR and NGFR was found both in control and noise-exposed animals, with the cell localization similar to that of growth factors. The increase in mRNA expression for bFGF and NGF was found in noise-exposed animals only after lower exposure to noise, on day 5 after exposure (p < 0.01). A lack of increased expression after higher exposure could be excused by larger damage of hair cells followed by the increase of mRNA for beta-actin to which the results were referred.
The results suggest bFGF and NGF involvement in postinjury regeneration of the basilar papilla. (c) 2005 Elsevier B.V. All rights reserved.
C1 Nofer Inst Environm Med, Dept Phys Hazards, PL-91348 Lodz, Poland.
RP Shwinska-Kowalska, M (reprint author), Nofer Inst Environm Med, Dept Phys Hazards, Teresy St 8, PL-91348 Lodz, Poland.
EM marsliw@imp.lodz.pl
RI Pawelczyk, Malgorzata/C-9853-2011
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NR 47
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 93
EP 103
DI 10.1016/j.heares.2005.08.005
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500010
ER
PT J
AU Getzmann, S
AF Getzmann, S
TI Shifting the onset of a moving sound source: A Frohlich effect in
spatial hearing
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 8th Tubinger Perception Conference
CY FEB, 2005
CL Tubingen, GERMANY
DE spatial hearing; acoustic target; motion perception; Frohlich effect;
attention
ID AUDIBLE MOVEMENT ANGLE; HORIZONTAL PLANE; LOCALIZATION; ATTENTION;
STIMULI; REPULSION; POSITION; AZIMUTH; CONTEXT; SPACE
AB When observers are presented with a visual target in motion, they typically remember its onset position to be displaced in the direction of motion. The present study investigated a similar effect in the auditory modality. In a dark anechoic environment, an auditory target (short noise pulses) appeared randomly at a peripheral or a central azimuthal position and moved from left to right or from right to left along the frontal horizontal plane. Relative judgments were made to determine the onset position of motion: Employing a two-alternative forced-choice task, listeners compared the onset position of the target to a 2-s visual reference stimulus presented at the left or right of the auditory onset position. In comparison with stationary targets, the onset positions of moving targets were localized as displaced in the direction of motion. The most prominent displacement occurred when the visual reference stimulus was presented after the auditory motion. With the reference stimulus presented before the auditory motion, the displacement was significantly reduced. Moreover, the displacement was stronger with peripheral than with central onset positions. These findings suggest the existence of a potential analogue of the Frohlich effect in the auditory modality. An auditory spatial attention mechanism is proposed that may have given rise to the observed pattern of results. (c) 2005 Elsevier B.V. All rights reserved.
C1 Ruhr Univ Bochum, Fac Psychol, D-44780 Bochum, Germany.
RP Getzmann, S (reprint author), Ruhr Univ Bochum, Fac Psychol, D-44780 Bochum, Germany.
EM Stephan.Getzmann@ruhr-uni-bochum.de
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NR 30
TC 6
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 104
EP 111
DI 10.1016/j.heares.2005.08.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500011
PM 16213116
ER
PT J
AU Otto, KJ
Rousche, PJ
Kipke, DR
AF Otto, KJ
Rousche, PJ
Kipke, DR
TI Microstimulation in auditory cortex provides a substrate for detailed
behaviors
SO HEARING RESEARCH
LA English
DT Article
DE microelectrode; cortical microstimulation; auditory cortex; rat;
behavior; discrimination; auditory prosthesis
ID HUMAN OCCIPITAL CORTEX; VISUAL AREA MT; INTRACORTICAL MICROSTIMULATION;
CORTICAL MICROSTIMULATION; ELECTRICAL-STIMULATION; EYE-MOVEMENTS;
PROSTHESIS; PERFORMANCE; DIRECTION; RAT
AB Sensory cortical prostheses have potential to aid people suffering from blindness, deafness and other sensory deficits. However, research to date has shown that sensation thresholds via epicortical stimulation are surprisingly large. These thresholds result in potentially deleterious electrical currents, as well as large activation volumes. Large activation volumes putatively limit the corresponding number of independent stimulation channels in a neural prosthesis. In this study, penetrating stimulation of the auditory cortex was tested for its ability to transmit salient information to behaving rat subjects. Here, we show that subjects that were previously trained to discriminate natural stimuli immediately discriminated different microstimulation cues more accurately and with shorter response latencies than the natural stimuli. Additionally, the cortical microstimulation resulted in a generalization gradient across locations within the cortex. The results demonstrate the efficacy of using closely spaced cortical microstimulation to efficiently transmit highly salient and discriminable information to a behaving subject. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA.
Univ Michigan, Dept Otolaryngol, Ann Arbor, MI 48109 USA.
Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA.
RP Kipke, DR (reprint author), Univ Michigan, Dept Biomed Engn, 1107 Gerstacker,2200 Bonisteel Blvd, Ann Arbor, MI 48109 USA.
EM kjotto@umich.edu; dkipke@umich.edu
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NR 33
TC 39
Z9 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2005
VL 210
IS 1-2
BP 112
EP 117
DI 10.1016/j.heares.2005.08.004
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 991EQ
UT WOS:000233795500012
PM 16209915
ER
PT J
AU Kong, WJ
Guo, CK
Zhang, S
Hao, J
Wang, YJ
Li, ZW
AF Kong, WJ
Guo, CK
Zhang, S
Hao, J
Wang, YJ
Li, ZW
TI The properties of ACh-induced BK currents in guinea pig type II
vestibular hair cells
SO HEARING RESEARCH
LA English
DT Article
DE ACh receptor; type II vestibular hair cells; large conductance;
Ca2+-activated K+ currents
ID NICOTINIC ACETYLCHOLINE-RECEPTOR; ACTIVATED POTASSIUM CHANNELS;
ION-DEPENDENT CONDUCTANCES; CA2+-ACTIVATED K+ CHANNELS; CHAT-LIKE
IMMUNOREACTIVITY; HIGH-CALCIUM PERMEABILITY; PROTEIN-KINASE-A;
CHOLINERGIC-RECEPTOR; SYNAPTIC-TRANSMISSION; MAMMALIAN COCHLEA
AB Molecular biological studies have demonstrated that both muscarinic receptor subtypes and nicotinic receptor subunits were located in mammalian vestibular sensorineural epithelium. However, the functional roles are Still unclear, with the exception of the well-known (alpha 9-containing nicotinic ACh receptor (alpha 9nAChR). In this study, the properties of acetylcholine (ACh)-induced currents were investigated by whole-cell patch clamp technique in isolated type It vestibular hair cells (VHCs II) of guinea pig. VHCs II displayed a sustained, non-inactivating current when extracellular application of ACh. ACh-induced currents restored gradually and it took about 60 s to get a complete recovery. ACh-induced current was not affected by extracellular Na+, but strongly affected by extracellular K+ and Ca2+. Depletion of the intracellular Ca2+ stores by intracellular application of inositol 1,4,5-trisphosphate (IP3) or blocking of the release of intracellular Ca2+ stores by intracellular application of heparin failed to inhibit this current. ACh-induced currents were inhibited by nifedipine, Cd2+, tetraethyl ammonium (TEA), charybdotoxin (CTX), iberiotoxin (IBTX), atropine and d-tubocurarine (DTC), respectively, but not by apamin. In conclusion, ACh stimulates a large conductance, Ca2+-activated K+ Current (BK) in guinea pig VHCs 11 by activation of the influx of Ca2+ ions, which is mediated by an ACh receptor that could not be defined to be the odd-number muscarinic receptor. (c) 2005 Elsevier BY. All rights reserved.
C1 Huazhong Univ Sci & Technol, Dept Otolaryngol, Union Hosp Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China.
Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Neurobiol, Wuhan, Peoples R China.
RP Kong, WJ (reprint author), Huazhong Univ Sci & Technol, Dept Otolaryngol, Union Hosp Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China.
EM wjkong889@yahoo.com
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NR 59
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Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2005.06.001
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900001
PM 16005587
ER
PT J
AU Tadros, SF
Frisina, ST
Mapes, F
Frisina, DR
Frisina, RD
AF Tadros, SF
Frisina, ST
Mapes, F
Frisina, DR
Frisina, RD
TI Higher serum aldosterone correlates with lower hearing thresholds: A
possible protective hormone against presbycusis
SO HEARING RESEARCH
LA English
DT Article
DE aldosterone; hormone; mineralocorticoids; adrenal; age; hearing loss;
presbycusis; HINT; otoacoustic emissions; stria vascularis
ID CORTICAL COLLECTING DUCT; NA+-K+-ATPASE; MESSENGER-RNA EXPRESSION;
QUIET-AGED GERBILS; STRIA VASCULARIS; ION-TRANSPORT; INNER-EAR;
TRANSEPITHELIAL VOLTAGE; INDUCED HYPERTENSION; EPITHELIAL-CELLS
AB Aldosterone hormone is a mineralocorticoid secreted by adrenal gland cortex and controls serum sodium (Na+) and potassium (K+) levels. Alclosterone has a stimulatory effect on expression of sodium-potassium ATPase (Na, K-ATPase) and sodium-potassium-chloride cotransporter (NKCC) in cell membranes. In the present investigation, the relation between serum aldosterone levels and age-related hearing loss (presbycusis) and the correlation between these levels versus the degree of presbycusis in humans were examined. Serum aldosterone concentrations were compared between normal hearing and presbycusic groups. Pure-tone audiometry, transient evoked otoacoustic emissions (TEOAE), hearing in noise test (HINT) and gap detection were tested for each subject and compared to the serum aldosterone levels. A highly significant difference between groups in serum aldosterone concentrations was found (p = 0.0003, t = 3.95, df = 45). Highly significant correlations between pure-tone thresholds in both right and left ears, and HINT scores versus serum aldosterone levels were also discovered. On the contrary, no significant correlations were seen in the case of TEOAEs and gap detection. We conclude that aldosterone hormone may have a protective effect on hearing in old age. This effect is more peripheral than central, appearing to affect inner hair cells more than outer hair cells. (c) 2005 Elsevier B.V. All rights reserved.
C1 Rochester Inst Technol, Int Ctr Hearing & Speech Res, Natl Tech Inst Deaf, Rochester, NY 14623 USA.
Univ Rochester, Sch Med & Dent, Dept Otolaryngol, Rochester, NY 14642 USA.
Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
Univ Rochester, Sch Med & Dent, Dept Biomed Engn, Rochester, NY 14642 USA.
RP Frisina, RD (reprint author), Rochester Inst Technol, Int Ctr Hearing & Speech Res, Natl Tech Inst Deaf, 52 Lomb Mem Dr, Rochester, NY 14623 USA.
EM rdf@q.ent.rochester.edu
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NR 74
TC 14
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 10
EP 18
DI 10.1016/j.heares.2005.05.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900002
PM 16039078
ER
PT J
AU Hofman, R
Segenhout, JM
Albers, FWJ
Wit, HP
AF Hofman, R
Segenhout, JM
Albers, FWJ
Wit, HP
TI The relationship of the round window membrane to the cochlear aqueduct
shown in three-dimensional imaging
SO HEARING RESEARCH
LA English
DT Article
DE round window membrane; cochlear aqueduct; OPFOS; perilymph; flow
resistance
ID GUINEA-PIG; RECONSTRUCTION; ANATOMY
AB The round window membrane and cochlear aqueduct complex in the guinea pig are reconstructed with 3D-imaging, using orthogonal plane fluorescence optical sectioning (OPFOS).
The 3D-images show that the periotic duct and the aqueduct are connected to a pouch-like extension of the round window. The function of this may be regulation of aqueduct flow resistance under the influence of a pressure difference between inner ear fluid and middle ear. (c) 2005 Published by Elsevier B.V.
C1 Univ Groningen Hosp, Dept Otolaryngol, NL-9700 RB Groningen, Netherlands.
RP Hofman, R (reprint author), Univ Groningen Hosp, Dept Otolaryngol, POB 30001, NL-9700 RB Groningen, Netherlands.
EM r.hofman@azg.kno.nl
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NR 18
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 19
EP 23
DI 10.1016/j.heares.2005.06.004
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900003
PM 16039079
ER
PT J
AU Choi, JY
Shin, JH
Kim, JL
Jung, SH
Son, EJ
Song, MH
Kim, SH
Yoon, JH
AF Choi, JY
Shin, JH
Kim, JL
Jung, SH
Son, EJ
Song, MH
Kim, SH
Yoon, JH
TI P2Y(2) agonist induces mucin secretion via Ca2+- and inositol
1,4,5-triphosphate-dependent pathway in human middle ear epithelial
cells
SO HEARING RESEARCH
LA English
DT Article
DE mucin; caffeine; signaling transduction; IP3; Ca2+
ID PROTEIN-KINASE-C; PANCREATIC ACINAR-CELLS; ION-TRANSPORT; RELEASE;
CALCIUM; CA2+; ACTIVATION; EXPRESSION; RECEPTOR; ATP
AB Purinergic agonists regulate mucin secretion in the airway epithelial cells. This study examined the effects of the apical application of purinergic agonists on Ca2+ influx ([CU2+](i)), and mucin secretion along with their underlying signaling pathway in normal human middle ear epithelial (NHMEE) cells. The apical membrane of NHMEE cells were stimulated with various purinergic agonists, including UTP, and the [Ca2+](i) was measured using a miniature Ussing double perfusion chamber. P2Y(2) receptor in NHMEE cells was also localized by immunohistochemistry. UTP-induced mucin secretion was quantified by an immunoblotting assay. The order of the purinergic agonist potency with respect to [Ca2+](i) determined in this study was ATP = UTP > 2-MeSATP > UDP > adenosine which is consistent with that obtained from P2Y(2) receptor activation. The P2Y(2) receptor is expressed in the apical membrane of monolayered cultured NHMEE cells. Apical UTP-induced [Ca2+]i was inhibited by 2-aminoethoxydiphenyl borate (2-APB) but not by ryanodine. UTP-induced mucin secretion was inhibited by a Ca2+ chelating agent, BAPTA-AM, and was stimulated by ionomycin. UTP-induced mucin secretion was also Suppressed by U73122 and 2-APB, while Calphostin C suppressed it to a small extent and PD98059 was ineffective. Caffeine also inhibited the UTP-induced [Ca2+](i) and mucin secretion. These results suggest that the P2Y(2) receptor is expressed in NHMEE cells, and plays a major role in modulating the [Ca2+](i) from the IP3-sensitive intracellular Ca2+ store. UTP-induced mucin secretion in NHMEE cells is strongly dependent on Ca2+- and IP3. (c) 2005 Elsevier B.V. All rights reserved.
C1 Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul 120752, South Korea.
Yonsei Univ, Coll Med, Brain Korea 21 Project Med Sci, Seoul, South Korea.
Yonsei Univ, Coll Med, Airway Mucus Inst, Seoul, South Korea.
Yonsei Univ, Dept Otorhinolaryngol, Wonju Coll Med, Wonju, South Korea.
RP Yoon, JH (reprint author), Yonsei Univ, Coll Med, Dept Otorhinolaryngol, 134 Shinchon Dong, Seoul 120752, South Korea.
EM jhyoon@yumc.yonsei.ac.kr
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NR 29
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 24
EP 31
DI 10.1016/j.heares.2005.05.012
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900004
PM 16139976
ER
PT J
AU Mortensen, MV
Madsen, S
Gjedde, A
AF Mortensen, MV
Madsen, S
Gjedde, A
TI Cortical responses to promontorial stimulation in postlingual deafness
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; PET; promontorial test; temporal processing
ID POSITRON-EMISSION-TOMOGRAPHY; COCHLEAR ELECTRICAL-STIMULATION;
AUDITORY-CORTEX; TEMPORAL RESOLUTION; HUMAN BRAIN; SPEECH RECOGNITION;
IMPLANT PATIENTS; FUNCTIONAL MRI; NORMAL-HEARING; PERCEPTION
AB dElectrical stimulation with a transtympanic electrode on the promontory of the middle ear allows the tasks of gap detection and temporal difference limen (TDL) to be carried out by both normally hearing and deaf subjects. Previous neuroirnaging of normally hearing subjects revealed a region in the right posterior temporal lobe that is crucial to duration discrimination. The present study tested the hypothesis that postlingually deaf subjects recruit this area when they make subtle temporal discriminations.
Fourteen postlingually deaf adult cochlear implant candidates were stimulated in the ear chosen for implantation. Altered cerebral activity was recorded with positron emission tomography as incremental 15-O-labelled water uptake.
On stimulation with tone bursts, we found bilateral activity close to the primary auditory cortex in all subjects. However, subjects performing well on the TDL task demonstrated right-lateralized fronto-temporal and left-lateralized temporal activity in the respective TDL and gap-detection tasks, while subjects who failed to detect duration differences of less than 200 ms in the TDL discrimination task only had frontal and occipital rather than temporal lobe activation. We conclude that the ability to involve the right posterior temporal region is important to duration discrimination. This ability can be evaluated pre-operatively. (c) 2005 Elsevier B.V. All rights reserved.
C1 Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus, Denmark.
Aarhus Univ Hosp, ENT Dept, DK-8000 Aarhus, Denmark.
Univ Aarhus, Ctr Functionally Integrat Neurosci, Aarhus, Denmark.
RP Mortensen, MV (reprint author), Aarhus Univ Hosp, PET Ctr, 44 Norrebrogade, DK-8000 Aarhus, Denmark.
EM malene@pet.auh.dk
RI Bonefeld, Birgit/B-7936-2010
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NR 56
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 32
EP 41
DI 10.1016/j.heares.2005.05.011
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900005
PM 16098697
ER
PT J
AU Kuypers, LC
Dirckx, JJJ
Decraemer, WF
Timmermans, JP
AF Kuypers, LC
Dirckx, JJJ
Decraemer, WF
Timmermans, JP
TI Thickness of the gerbil tympanic membrane measured with confocal
microscopy
SO HEARING RESEARCH
LA English
DT Article
DE eardrum; pars tensa; pars flaccida; modeling middle ear; confocal
fluorescence microscopy
ID EXPERIMENTAL OTITIS-MEDIA; MIDDLE-EAR DEVELOPMENT; MONGOLIAN GERBIL;
PARS FLACCIDA; STATIC PRESSURE; EXPERIMENTAL CHOLESTEATOMA; DISPLACEMENT
PATTERNS; ANNULUS FIBROSUS; SMOOTH-MUSCLE; EFFUSION
AB Thickness data for the gerbil tympanic membrane, an extremely thin biological membrane, are presented. Thickness measurements were performed on fresh material using fluorescence images taken perpendicular through the membrane with a commercial confocal microscope.
Thickness varies strongly across the membrane. Similar thickness distributions in all samples (pars tensa n = 11; pars flaccida n = 3) were observed. The pars tensa has a rather constant thickness of about 7 mu m in the central region curving as a horse shoe upwards around the manubrium. In the most superior parts of the pars tensa thickness becomes gradually twice as large. Thickness increases also steeply from the central region towards the edges (about 35 mu m near the annulus and 20 mu m near the manubrium). A pronounced, local thickening of about 30 mu m is present close to the edge and extends as a ring along the entire annular periphery of the pars tensa. Overall, the pars flaccida is thicker than the pars tensa and has a rugged surface. Its central region has a mean thickness of about 24 mu m with a mean variation of about 4 mu m. The average thickness in the inferior region is slightly larger than in the superior region. The pars flaccida thickens steeply, up to about 80 mu m, near the edges. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Antwerp, Dept Phys, Lab Biomed Phys, B-2020 Antwerp, Belgium.
Univ Antwerp, Dept Biomed Sci, Cell Biol & Histol Lab, B-2020 Antwerp, Belgium.
RP Kuypers, LC (reprint author), Univ Antwerp, Dept Phys, Lab Biomed Phys, Campus Middelheim,Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
EM Liesbeth.Kuypers@ua.ac.be
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NR 35
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 42
EP 52
DI 10.1016/j.heares.2005.06.003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900006
PM 16054789
ER
PT J
AU Fujimura, T
Suzuki, H
Shimizu, T
Tokui, N
Kitamura, T
Udaka, T
Doi, Y
AF Fujimura, T
Suzuki, H
Shimizu, T
Tokui, N
Kitamura, T
Udaka, T
Doi, Y
TI Pathological alterations of strial capillaries in dominant white
spotting W/W-v mice
SO HEARING RESEARCH
LA English
DT Article
DE dominant white spotting mouse; strial capillaries; intermediate cells;
basement membrane; IgG deposition; permeability
ID INNER-EAR; W-LOCUS; PROTO-ONCOGENE; VASCULARIS; MOUSE; MELANOCYTES;
ABNORMALITIES; PIGMENTATION; MECHANISMS; DEAFNESS
AB Dominant white spotting W/W-v and W-v/W-v mice are well-known mutants that lack strial intermediate cells in their cochlea and manifest hereditary sensorineural hearing loss. We recently reported marked thickening of and lgG deposition on the basement membrane of strial capillaries in W/W-v mutant mice, similar to observations made in aged animals and in animals with autoimmune sensorineural hearing loss. The present study aimed to clarify the age-dependent changes in these pathological findings of strial capillaries in the W/W-v mice.
Male WBB6FI +/+ and dominant white spotting W/W-v mutant mice were sacrificed by transcardiac perfusion with paraformaldehyde solution. The cochlear ducts were isolated and Subjected to light- and electron-microscopy, immunohistochemistry, immuno-electron microscopy. Alternatively, lanthanum chloride tracer examination in the isolated cochlear ducts was performed in order to compare the permeability of the strial capillaries between +/+ and W/W-v mice.
In the W/W-v mice, thickening of and IgG deposition on the basement membrane of strial capillaries were observed as early as I week after birth and became more noticeable with age. Deposited IgG was preferentially localized to the thickened basement membrane and was also observed in partially the intercellular space between adjacent of endothelial cells. In addition, pinocytotic vesicles both in the apical and basal lesions of such cells also showed IgG deposition. Lanthanum chloride was retained along apical plasma membrane of the endothelial cells in the +/+ mice but penetrated through the enclothelial layer in the W/W-v mice.
These results indicate that active transport via pinocytotic vesicles as well as increased permeability of strial capillaries in the W/W-v mice occur in the early stage after birth, resulting in the morphological alterations in the strial capillaries of these mice. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Occupat & Environm Hlth, Sch Med, Dept Otorhinolaryngol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan.
Univ Occupat & Environm Hlth, Sch Med, Dept Anat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan.
RP Suzuki, H (reprint author), Univ Occupat & Environm Hlth, Sch Med, Dept Otorhinolaryngol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan.
EM suzuhyde@med.uoeh-u.ac.jp
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NR 25
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 53
EP 59
DI 10.1016/j.heares.2005.05.013
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900007
PM 16054310
ER
PT J
AU Varghese, GI
Zhu, XX
Frisina, RD
AF Varghese, GI
Zhu, XX
Frisina, RD
TI Age-related declines in distortion product otoacoustic emissions
utilizing pure tone contralateral stimulation in CBA/CaJ mice
SO HEARING RESEARCH
LA English
DT Article
DE medial olivocochlear system; contralateral suppression; distortion
product otoacoustic emissions; age-related hearing loss; CBA/CaJ mice;
presbycusis; outer hair cells; efferent system; pure tone
ID COCHLEAR MICROMECHANICAL PROPERTIES; EFFERENT OLIVOCOCHLEAR NEURONS;
AUDITORY-NERVE FIBERS; ELECTRICAL-STIMULATION; INFERIOR COLLICULUS;
ACOUSTIC STIMULATION; CALBINDIN D-28K; HUMAN LISTENERS; GUINEA-PIG; CBA
MOUSE
AB One role of the medial olivocochlear (MOC) auditory efferent system is to suppress cochlear outer hair cell (OHC) responses when presented with a contralateral sound. Using distortion product otoacoustic emissions (DPOAEs), the effects of active changes in OHC responses due to the MOC as a function of age can be observed when contralateral stimulation with a pure tone is applied. Previous studies have shown that there are age-related declines of the MOC when broad band noise is presented to the contralateral ear. In this study, we measured age-related changes in CBA/CaJ mice by comparing DPOAE generation with and without a contralateral pure tone at three different frequencies (12, 22, and 37 kHz). Young (n = 16), middle (n = 10) and old-aged (17 = 10) CBA mice were tested. DPOAE-grams were obtained using L1 = 65 and L2 = 50 dB SPL, F1/F2 = 1.25, using eight points per octave covering a frequency range from 5.6-44.8 kHz. The pure tone was presented contralaterally at 55 dB SPL. DPOAE-grams and ABR levels indicated age-related hearing loss in the old mice. In addition, there was an overall change in DPOAEs in the middle-aged and old groups relative to the young. Pure tone stimulation was not as effective as a suppressor compared to broadband noise. An increase in pure tone frequency from 12 to 22 kHz induced greater suppression of DPOAEs, but the 37 kHz was least effective. These results indicate that as the mouse ages, there are significant changes in the efficiency of the suppression mechanism as elicited by contralateral narrowband stimuli. These findings reinforce the idea that age-related changes in the MOC or the operating points of OHCs play a role in the progression of presbycusis-age-related hearing loss in mammals. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Rochester, Sch Med & Dent, Dept Otolaryngol, Rochester, NY 14642 USA.
Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642 USA.
Univ Rochester, Sch Med & Dent, Dept Biomed Engn, Rochester, NY 14642 USA.
Rochester Inst Technol, Int Ctr Hearing Speech Res, Natl Tech Inst Deaf, Rochester, NY 14623 USA.
RP Frisina, RD (reprint author), Univ Rochester, Sch Med & Dent, Dept Otolaryngol, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM rdf@q.ent.rochester.edu
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NR 37
TC 24
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 60
EP 67
DI 10.1016/j.heares.2005.06.006
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900008
PM 16061336
ER
PT J
AU Avan, P
Bonfils, P
AF Avan, P
Bonfils, P
TI Distortion-product otoacoustic emission spectra and high-resolution
audiometry in noise-induced hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emissions; audiometry; noise-induced hearing loss; sensory
cell loss
ID AUDITORY BRAIN-STEM; GUINEA-PIG; FREQUENCY SPECIFICITY;
BASILAR-MEMBRANE; ACOUSTIC TRAUMA; CELL LOSS; LEVEL; COCHLEA; RESPONSES;
DAMAGE
AB dDistortion product otoacoustic emissions (DPOAE) elicited by 60dB SPL pure tones at A and f2 were collected at 2f1-f2, in 1/10th octave steps, in a sample of 36 ears from 27 patients with noise-induced hearing loss (NIHL). They were analyzed in the frequency domain against the outcome of high-resolution pure-tone audiometry, performed with the help of a Bekesy sweep-frequency automatic audiometer. The characteristics of DPOAE level plots as a function of frequency (the so-called DP-grams), relative to the DPOAE levels of a control age-matched group, were compared to their alleged counterparts on the audiograms, i.e., the lower and upper frequency boundaries of the interval with hearing loss. Ears with NIHL split into two subgroups, one (n = 25) with a notch in the DP-gram such that its lower boundary matched the lower limit of the audiometric notch (linear regression with a slope of 0.91, r(2) = 0.644, p < 0.001). Likewise, when it existed, its upper boundary matched its upper counterpart on the audiogram (linear regression with a slope of 0.96, r(2) = 0.89, P < 0.001). In this respect, DP-grams performed better than transient-evoked OAE spectra, which exhibited poor correlations with audiogram patterns. The second subgroup (n = 11) exhibited normal DPOAEs at all frequencies despite audionnetric losses similar to those of the first subgroup. In all cases, DPOAE levels were poor predictors of the degree of hearing losses. It is hypothesized that NIHL in the second subgroup involves inner hair cells or auditory neurons, instead of outer hair cells in the first subgroup. Provided NIHL affected outer hair cells, DP-grams provided a comparatively accurate predictor of the spectral extent of hearing loss. (c) 2005 Elsevier B.V. All rights reserved.
C1 Sch Med, Lab Sensory Biophys, F-63000 Clermont Ferrand, France.
UPRESA, CNRS, ENT Dept, European Hosp Georges Pompidou, F-7060 Paris, France.
RP Avan, P (reprint author), Sch Med, Lab Sensory Biophys, POB 38, F-63000 Clermont Ferrand, France.
EM paul.avan@u-clermont1.fr
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NR 30
TC 11
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 68
EP 75
DI 10.1016/j.heares.2005.06.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900009
PM 16112827
ER
PT J
AU Keithley, EM
Canto, C
Zheng, QY
Wang, XB
Fischel-Ghodsian, N
Johnson, KR
AF Keithley, EM
Canto, C
Zheng, QY
Wang, XB
Fischel-Ghodsian, N
Johnson, KR
TI Cu/Zn superoxide dismutase and age-related hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE presbycusis; aging; cochlea; mice; hearing; mitochondria
ID HAIR-CELLS; TRANSGENIC MICE; INBRED STRAINS; C57BL/6J MICE; MN-SOD;
COCHLEA; MOUSE; OVEREXPRESSION; DEGENERATION; LOCALIZATION
AB Mice, in which the genetics can be manipulated and the life span is relatively short, enable evaluation of the effects of specific gene expression on cochlear degeneration over time. Antioxidant enzymes such as Cu/Zn superoxide dismutase (SOD I) protect cells from toxic, reactive oxygen species and may be involved in age-related degeneration. The effects of SODI deletion and over-expression on the cochlea were examined in Sodl-null mice, Sodl transgenic mice and in age- and genetics-matched controls. Auditory brainstern responses (ABR) were measured and cochleae were histologically examined. The absence of SOD] resulted in hearing loss at an earlier age than in wildtype or heterozygous mice. The cochleae of the null mice had severe spiral ganglion cell degeneration at 7-9 months of age. The stria vascularis in the aged, null mice was thinner than in the heterozygous or wildtype mice. Over-expression of SODI did not protect against hearing loss except at 24 months of age. In conclusion, SOD] seems important for survival of cochlear neurons and the stria vascularis, however even half the amount is sufficient and an over abundance does not provide much protection from age-related hearing loss. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Calif San Diego, Div Otolaryngol Head & Neck Surg, La Jolla, CA 92093 USA.
Vet Affairs Med Ctr, La Jolla, CA 92161 USA.
Jackson Lab, Bar Harbor, ME 04609 USA.
Steven Spielberg Pediat Res Ctr, Inst Med Genet, Ahmanson Dept Pediat, Cedars Sinai Res Inst, Los Angeles, CA 90048 USA.
Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90048 USA.
Xian Jiaotong Univ, Sch Med, Xian, Peoples R China.
RP Keithley, EM (reprint author), Univ Calif San Diego, Div Otolaryngol Head & Neck Surg, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM ekeithley@ucsd.edu
RI Zheng, Qing/C-1731-2012
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NR 45
TC 49
Z9 55
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 76
EP 85
DI 10.1016/j.heares.2005.06.009
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900010
PM 16055286
ER
PT J
AU Uemaetomari, I
Tabuchi, K
Hoshino, T
Hara, A
AF Uemaetomari, I
Tabuchi, K
Hoshino, T
Hara, A
TI Protective effect of calcineurin inhibitors on acoustic injury of the
cochlea
SO HEARING RESEARCH
LA English
DT Article
DE acoustic injury; cochlea; calcineurin; cyclosporine A; FK506; rapamycin
ID CYCLOSPORINE-A; ISCHEMIA; NOISE; FK-506; CELLS
AB This study examined the effect of immunosuppressants, cyclosporin A. FK506 and rapamycin on functional recovery of the cochlea after acoustic overexposure,. in guinea pigs and mice. Thirty guinea pigs were exposed to a 2kHz pure tone at 120dB SPL for 10min. The compound action potential threshold shift induced by acoustic overexposure was examined. Twenty-five mice were exposed to a 4kHz pure tone at 128dB SPL for 4h. Auditory brainstem response was used to examine the hearing threshold shift. In both the guinea pig and mouse experiments, cyclosporin A and FK506, intraperitonally given just before acoustic overexposure, significantly decreased the hearing threshold shift one or two weeks after acoustic overexposure. However, neither rapamycin nor the FK506 and rapamycin combined treatment groups showed improvement of the threshold shift. The present findings suggest that these two calcineurin inhibitors have a protective effect against acoustic injury of the cochlea, whereas the non-calcineurin inhibitor, rapamycin, not only has no effect against acoustic injury, but rather blocked the effect of FK506. This indicated a possible role of calcineurin against acoustic injury. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Tsukuba, Inst Clin Med, Dept Otolaryngol, Tsukuba, Ibaraki 3058575, Japan.
RP Hara, A (reprint author), Univ Tsukuba, Inst Clin Med, Dept Otolaryngol, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
EM haraakir@md.tsukuba.ac.jp
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NR 14
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 86
EP 90
DI 10.1016/j.heares.2005.06.010
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900011
PM 16084678
ER
PT J
AU Wangemann, P
Wonneberger, K
AF Wangemann, P
Wonneberger, K
TI Neurogenic regulation of cochlear blood flow occurs along the basilar
artery, the anterior inferior cerebellar artery and at branch points of
the spiral modiolar artery
SO HEARING RESEARCH
LA English
DT Article
DE sympathetic nervous system; electric field stimulation; cochlear blood
flow
ID GUINEA-PIG; IN-VITRO; INNERVATION; VASOCONSTRICTION; VASODILATATION;
RABBIT
AB The cochlea receives its main blood supply from the basilar artery via the anterior inferior cerebellar artery and the spiral modiolar artery. Morphologic studies have shown sympathetic innervation along the spiral rnodiolar artery of the gerbil and the guinea pig and functional studies in the isolated in vitro superfused spiral modiolar artery of the gerbil have demonstrated norepinephrine-induced vasoconstrictions via alpha(1A)-adrenergic receptors. It is Current unclear whether the sympathetic innervation is physiologically relevant. Stimulation of sympathetic ganglia in guinea pigs has been shown to alter cochlear blood flow in situ. Whether these changes originated from local or more systemic changes in the vascular diameter remained uncertain. The goal of the present study was to demonstrate the presence or absence of neurogenic changes in the diameter of the isolated in vitro superfused spiral modiolar artery, anterior inferior cerebellar artery and basilar artery from the gerbil and the guinea pig. Vascular diameter was monitored by videomicroscopy. Electric field stimulation Was used to elicit neurotransmitter release. A reversible inhibitory effect of 10(-6) M tetrodotoxin was taken as criterion to discriminate between neurogenic and myogenic changes in vascular diameter. Mesentery arteries of comparable diameter, which are known to respond with a neurogenic vasoconstriction to electric field stimulation, served as controls. Basilar artery, anterior inferior cerebellar artery, spiral modiolar artery and mesentery arteries constricted in response to electric field stimulation. No dilations were observed. Myogenic and neurogenic vasoconstrictions were observed in all vessels. These observations suggest that the sympathetic innervation of the basilar artery, the anterior inferior cerebellar artery and branch points of the spiral modiolar artery is involved in a physiologically relevant control of the vascular diameter in the gerbil and the guinea pig. (c) 2005 Elsevier B.V. All rights reserved.
C1 Kansas State Univ, Cell Physiol Lab, Anat & Physiol Dept, Manhattan, KS 66506 USA.
Univ Regensburg, HNO Klin, D-8400 Regensburg, Germany.
RP Wangemann, P (reprint author), Kansas State Univ, Cell Physiol Lab, Anat & Physiol Dept, 205 Coles Hall, Manhattan, KS 66506 USA.
EM wange@vet.ksu.edu
RI Wangemann, Philine/N-2826-2013
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NR 17
TC 8
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 91
EP 96
DI 10.1016/j.heares.2005.06.011
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900012
PM 16054311
ER
PT J
AU Philibert, B
Laudanski, J
Edeline, JM
AF Philibert, B
Laudanski, J
Edeline, JM
TI Auditory thalamus responses to guinea-pig vocalizations: A comparison
between rat and guinea-pig
SO HEARING RESEARCH
LA English
DT Article
DE medial geniculate body; neuronal selectivity; natural and time-reversed
calls; single unit
ID SPECIES-SPECIFIC VOCALIZATIONS; SQUIRREL-MONKEY; CORTEX NEURONS;
REPRESENTATION; STIMULI; CELLS; FOREBRAIN; MARMOSET; SONG
AB Although neuronal responses to species-specific vocalizations have long been described, very few between-species comparisons have been made. In a previous study, a differential representation of species-specific vocalizations was found in the auditory cortex (ACx): marmoset ACx neurons responded more, and more selectively, to marmoset calls than did cat ACx neurons [Wang, X., Kadia, S.C., 2001. Differential representation of species-specific primate vocalizations in the auditory cortices of marmoset and cat. J. Neurophysiol. 86, 2616-2620]. The present study analyzed responses of guinea-pig and rat auditory thalamus neurons to four well-defined guinea-pig vocalizations. Neurons of guinea-pigs (n = 96) and rats (n = 87) displayed similar response strength to guinea-pig vocalizations, and did not exhibit a preference for the natural over the time-reversed version of the calls in both species. This difference with the study by Wang and Kadia might suggest that, in mammals, the selectivity for the natural version of species-specific vocalizations is prominent only at the cortical level. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Paris 11, CNRS, UMR 8620, NAMC, F-91405 Orsay, France.
RP Edeline, JM (reprint author), Univ Paris 11, CNRS, UMR 8620, NAMC, Batiment 446, F-91405 Orsay, France.
EM jean-marc.edeline@ibaic.u-psud.fr
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NR 24
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 97
EP 103
DI 10.1016/j.heares.2005.07.004
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900013
PM 16139975
ER
PT J
AU Brumwell, CL
Hossain, WA
Morest, DK
Wolf, B
AF Brumwell, CL
Hossain, WA
Morest, DK
Wolf, B
TI Biotinidase reveals the morphogenetic sequence in cochlea and cochlear
nucleus of mice
SO HEARING RESEARCH
LA English
DT Article
DE auditory system; hearing loss; immunohistochernistry; light microscopy;
syndromic deafness; development; vestibular ganglion
ID IN-SITU HYBRIDIZATION; HEARING-LOSS; INNER-EAR; INNERVATION; DEFICIENCY;
LOCALIZATION; MIGRATION; MOUSE; CELLS; DIFFERENTIATION
AB Hearing loss affects children with biotinidase deficiency, an inherited metabolic disorder in the recycling of biotin. The deficit appears shortly after birth during development of the auditory system. Using a mouse model, we sought to discover where and when biotinidase is expressed in the normal development of the cochlea and cochlear nucleus. In the process, we reconstructed the normal morphogenetic sequences of the constituent cells. Immunolabeling for biotinidase was localized to neurons and other cells of the adult and immature mouse, including the embryonic precursors of these regions dating from the stage of the otocyst. Its distribution was compared to the particular morphological changes occurring at each developmental stage. Biotinidase was localized in cells and their processes at the critical stages in their proliferation, migration, structural differentiation, and innervation, covering the entire span of their development. The prevalence of immunostaining peaked in the adult animal, including hair cells and ganglion cells of the cochlea and neurons of the cochlear nucleus. The findings suggest that biotinidase plays a role in the normal development of the auditory system. Besides the pattern of localization of biotinidase, this study provides the first systematic account of each developmental stage in a mammalian auditory system. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Connecticut, Ctr Hlth, Dept Neurosci, Farmington, CT 06030 USA.
Univ Connecticut, Ctr Hlth, Dept Pediat, Farmington, CT 06030 USA.
Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA.
Connecticut Childrens Med Ctr, Hartford, CT USA.
RP Morest, DK (reprint author), Univ Connecticut, Ctr Hlth, Dept Neurosci, 263 Farmington Ave, Farmington, CT 06030 USA.
EM kentmorest@neuron.uchc.edu
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NR 39
TC 3
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2005
VL 209
IS 1-2
BP 104
EP 121
DI 10.1016/j.heares.2005.06.013
PG 18
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 987JT
UT WOS:000233514900014
PM 16107307
ER
PT J
AU Matsumoto, N
Kalinec, F
AF Matsumoto, N
Kalinec, F
TI Prestin-dependent and prestin-independent motility of guinea pig outer
hair cells
SO HEARING RESEARCH
LA English
DT Article
DE guinea pig; outer hair cells; OHCs motility; patch-clamp; video
microscopy
ID INDUCED SLOW MOTILITY; MOTOR PROTEIN; MEMBRANE CAPACITANCE; COCHLEAR
AMPLIFIER; FORCE GENERATION; ELECTROMOTILITY; MECHANISM; VOLTAGE;
CALCIUM; ACETYLCHOLINE
AB The motile response of isolated guinea pig outer hair cells (OHCs) was investigated using a combination of whole-cell patch clamp recording and continuous video image analysis. OHC's length, width, and area were measured from video images and the cell volume estimated from these values. Morphological data was then correlated with electrophysiological recordings of whole-cell current, membrane potential and voltage-dependent non-linear capacitance. Electromotility was evoked either by manipulating the membrane potential under voltage-clamp conditions or by exposing OHCs to high K+ solutions. Other motile responses were investigated in voltage-clamp experiments at constant holding potential, or exposing OHCs to solutions that did not affect the membrane potential. We found that electrical stimulation evoked voltage-dependent changes in OHC's length, width and area but not in cell volume regardless of the time course of stimulation. Moreover, changes in cell area were always associated with both voltage-dependent motility and non-linear capacitance, suggesting prestin dependency. In contrast, voltage-independent motile responses at constant membrane potential, which are presumed to be prestin-in dependent, were associated with changes in cell length, width and volume without significant changes in area. Area measurements, then, become a tool to investigate the simultaneous occurrence of both prestin-dependent and prestin-independent OHC motilities, and for evaluating the individual contribution of each mechanism to the total cell movement. (c) 2005 Elsevier B.V. All rights reserved.
C1 House Ear Res Inst, Gonda Dept Cell & Mol Biol, Sect Cell Struct & Funct, Los Angeles, CA 90057 USA.
RP Kalinec, F (reprint author), House Ear Res Inst, Gonda Dept Cell & Mol Biol, Sect Cell Struct & Funct, 2100 W 3rd St, Los Angeles, CA 90057 USA.
EM fkalinec@hei.org
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NR 38
TC 10
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 1
EP 13
DI 10.1016/j.heares.2005.03.030
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900001
PM 16000248
ER
PT J
AU Harris, KC
Hu, BH
Hangauer, D
Henderson, D
AF Harris, KC
Hu, BH
Hangauer, D
Henderson, D
TI Prevention of noise-induced hearing loss with Src-PTK inhibitors
SO HEARING RESEARCH
LA English
DT Article
DE noise trauma; cochlea; Src-PTK
ID N-TERMINAL KINASE; PP60(C-SRC) TYROSINE KINASE; ATP COMPETITIVE
INHIBITORS; MESSENGER-RNA EXPRESSION; FOCAL ADHESION KINASE; HAIR
CELL-DEATH; INDUCED APOPTOSIS; OXIDASE ACTIVITY; NAD(P)H OXIDASE; MOUSE
COCHLEA
AB Studies from our lab show that noise exposure initiates cell death by multiple pathways [Nicotera, T.M., Hu, B.H., Henderson, D., 2003. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea. J. Assoc. Res. Otolaryngol. 4, 466-477] therefore, protection against noise may be most effective with a multifaceted approach. The Src protein tyrosine kinase (PTK) signaling cascade may be involved in both metabolic and mechanically induced initiation of apoptosis in sensory cells of the cochlea. The current study compares three Src-PTK inhibitors, KX1-004, KX1-005 and KX1-174 as potential protective drugs for NIHL. Chinchillas were used as subjects. A 30 mu l drop of one of the Src inhibitors was placed on the round window membrane of the anesthetized chinchilla; the vehicle (DMSO and buffered saline) alone was placed on the other ear. After the drug application, the middle ear was sutured and the subjects were exposed to noise. Hearing was measured before and several times after the noise exposure and treatment using evoked responses. At 20 days post-exposure, the animals were anesthetized their cochleae extracted and cochleograms were constructed. All three Src inhibitors provided protection from a 4 h, 4 kHz octave band noise at 106 dB. The most effective drug, KX1-004 was further evaluated by repeating the exposure with different doses, as well as, substituting an impulse noise exposure. For all conditions, the results suggest a role for Src-PTK activation in noise-induced hearing loss (NIHL), and that therapeutic intervention with a Src-PTK inhibitor may offer a novel approach in the treatment of NIHL. (c) 2005 Elsevier B.V. All rights reserved.
C1 Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
SUNY Buffalo, Dept Chem, Buffalo, NY 14214 USA.
RP Harris, KC (reprint author), Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,POB 250550, Charleston, SC 29425 USA.
EM harriskc@musc.edu
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NR 41
TC 33
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 14
EP 25
DI 10.1016/j.heares.2005.04.009
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900002
PM 15950415
ER
PT J
AU Nizami, L
AF Nizami, L
TI Dynamic range relations for auditory primary afferents
SO HEARING RESEARCH
LA English
DT Article
DE dynamic range; cat; intensity-difference limen; Signal Detection Theory
ID RATE-INTENSITY FUNCTIONS; DORSAL COCHLEAR NUCLEUS;
CROSSED-OLIVOCOCHLEAR-BUNDLE; NERVE-FIBER RESPONSES; RATE-LEVEL
FUNCTIONS; DISCHARGE PATTERNS; INFERIOR COLLICULUS; TONE BURSTS;
GUINEA-PIG; PURE-TONES
AB Dynamic range is one of four attributes typically assigned to the plot of firing rate vs. stimulus level of an auditory primary afferent. Dynamic range is generally understood to be the contiguous range of sound-pressure-level over which the neuron can indicate some small level change. Typically, however, dynamic range has been quantified as the width in decibels between the endpoints of the rate-level plot, which is not a measure of sensitivity to level change. A sensitivity measure is provided here by first deriving an equation for the intensity-difference limen (DL) in terms of attributes of the rate-level curve. The result is a generally U-shaped curve of DL vs. level. Any given criterion DL corresponds to a horizontal line cutting the DL curve at two points, with the separation in decibels between those points providing a dynamic range for that DL criterion. Plotting the dynamic ranges vs. the respective DLs yields a dynamic range curve. These were made for 62 afferents from the cat. The dynamic ranges of sloping-saturating rate-level plots do not exceed those for sigmoidal plots until the DL criterion reaches 50 dB, supporting the conclusion of Palmer and Evans [Cochlear fibre rate-intensity functions: no evidence for basilar membrane nonlinearities, Hearing Research 2 (1980) 319-326] that sloping saturation is not a reflection of cochlear nonlinearity. (c) 2005 Elsevier B.V. All rights reserved.
C1 Boys Town Natl Res Hosp, Ctr Hearing Res, Omaha, NE 68131 USA.
RP Nizami, L (reprint author), 1312 Grayson Pl, Decatur, GA 30030 USA.
EM nizamii2@aol.com
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NR 61
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 26
EP 46
DI 10.1016/j.heares.2005.05.002
PG 21
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900003
PM 16005586
ER
PT J
AU Gifford, RH
Bacon, SP
AF Gifford, RH
Bacon, SP
TI The effect of a steep high-frequency hearing loss on growth-of-masking
functions in simultaneous masking for f(m) < f(s)
SO HEARING RESEARCH
LA English
DT Article
DE growth of masking; GOM; Equivalent Rectangular Band width, ERB; signal
frequency, f(s); masker frequency, f(m)
ID LEVEL-DEPENDENT SHIFTS; BASILAR-MEMBRANE; CHINCHILLA COCHLEA; BEHAVIORAL
MEASUREMENT; VIBRATION PATTERN; TUNING CURVES; MECHANICS; MASKERS;
TONES; NONLINEARITIES
AB In normal-hearing subjects, the slope of the growth-of-masking (GOM) function obtained in simultaneous masking when the masker frequency (f(m)) is much less than the signal frequency (f(s)) often changes from a value near 2.0 to a value near 1.0 at high levels. The purpose of the present study was to evaluate whether this change in slope reflects a basal shift in the peak of the signal's basilar-membrane vibration pattern. To discourage the use of basally shifted peak excitation, GOM functions were obtained in seven subjects with a precipitously sloping high-frequency hearing loss. The signal was located at the normal-hearing edge of the loss, and the masker was located 3 equivalent rectangular bandwidths below f(s). In addition, GOM functions for an fs of 2000 Hz were obtained in four subjects with normal hearing, either "in quiet"' or in the presence of a restrictor tone with a frequency of 2400 or 2600 Hz and a level of 90 dB SPL. Overall, the results generally are not consistent with the change in slope at high levels being due to a basal shift in the peak of the signal's basilar-membrane vibration pattern. Instead, the results are consistent with a decrease in compression at high input levels at the place corresponding to f(s). (c) 2005 Elsevier B.V. All rights reserved.
C1 Arizona State Univ, Dept Speech & Hearing Sci, Psychoacoust Lab, Tempe, AZ 85287 USA.
RP Gifford, RH (reprint author), Arizona State Univ, Dept Speech & Hearing Sci, Psychoacoust Lab, POB 870102, Tempe, AZ 85287 USA.
EM Rene.Gifford@asu.edu
CR American National Standards Institute (ANSI), 1996, S361996 ANSI
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NR 27
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 47
EP 53
DI 10.1016/j.heares.2005.05.001
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900004
PM 16039077
ER
PT J
AU Guo, YK
Zhang, CX
Du, XP
Nair, U
Yoo, TJ
AF Guo, YK
Zhang, CX
Du, XP
Nair, U
Yoo, TJ
TI Morphological and functional alterations of the cochlea in
apolipoprotein E gene deficient mice
SO HEARING RESEARCH
LA English
DT Article
DE apolipoprotein E; hyperlipidemia; atherosclerosis; endothelial
dysfunction; hearing loss; mouse
ID SENSORINEURAL HEARING-LOSS; E-KNOCKOUT MICE; SPIRAL MODIOLAR ARTERY;
ENDOTHELIAL DYSFUNCTION; AUDITORY FUNCTION; NITRIC-OXIDE; EXPERIMENTAL
HYPERCHOLESTEROLEMIA; ATHEROSCLEROTIC LESIONS; HYPERLIPIDEMIC MICE;
NOISE EXPOSURE
AB The relationship between hyperlipidemia and sensorineural hearing loss remains obscure. In this study, we elucidate for the first time the cochlear morphological and auditory alterations and their relationships with hyperlipidemia, atherosclerosis, and endothelial dysfunction in apolipoprotem-E knockout (ApoE-KO) mice. Ten-week-old ApoE-KO mice were fed either atherosclerotic diet (1.25% cholesterol) or normal diet. Wild type mice (C57BL/6J) served as normal controls. Fourteen weeks later, marked hyperlipidemia, atherosclerosis, endothelial dysfunction, and hearing impairment, especially in the high frequencies, had developed in ApoE-KO mice as compared with C57BL/6J mice (P < 0.001). A high positive correlation between hearing loss and the extent of atherosclerosis and plasma total cholesterol levels was found. Hearing loss, especially at high frequencies, was detected in all ApoE-KO mice. Hair cell loss mainly at the base turn, thickening of vascular intima, and lumen stenosis of the spiral modiolar artery (SMA) in cochlea were also found; these histological changes were exacerbated by the atherosclerotic diet. Furthermore, endothelial nitric oxide synthase (eNOS) in aortic wall and cochlea was distinctly reduced in ApoE-KO mice. These results demonstrate that hyperlipidemia and atherosclerosis can induce alterations in cochlear morphology and function. The stenosis of SMA, which may cause cochlear ischemia and hypoxia, endothelial dysfunction, and low eNOS activity, may contribute to hearing loss. (c) 2005 Elsevier B.V. All rights reserved.
C1 Vet Adm Med Ctr, Coll Med, Dept Med, Div Allergy Immunol, Memphis, TN 38104 USA.
Vet Adm Med Ctr, Coll Med, Dept Mol Sci, Div Allergy Immunol, Memphis, TN 38104 USA.
Vet Adm Med Ctr, Coll Med, Dept Otolaryngol, Div Allergy Immunol, Memphis, TN 38104 USA.
Vet Adm Med Ctr, Coll Med, Inst Neurosci, Memphis, TN 38104 USA.
Cent S Univ, Xiangya Hosp 2, Dept Otolaryngol, Changsha 410011, Peoples R China.
Cent S Univ, Xiangya Hosp 2, Inst Hearing Res, Changsha 410011, Peoples R China.
Univ Tennessee, Coll Med, Vasc Biol Ctr Excellence, Memphis, TN 38163 USA.
RP Yoo, TJ (reprint author), Vet Adm Med Ctr, Coll Med, Dept Med, Div Allergy Immunol, Memphis, TN 38104 USA.
EM tyoo@utmem.edu
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NR 55
TC 30
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 54
EP 67
DI 10.1016/j.heares.2005.05.010
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900005
PM 16051453
ER
PT J
AU Parazzini, M
Bell, S
Thuroczy, G
Molnar, F
Tognola, G
Lutman, ME
Ravazzani, P
AF Parazzini, M
Bell, S
Thuroczy, G
Molnar, F
Tognola, G
Lutman, ME
Ravazzani, P
TI Influence on the mechanisms of generation of distortion product
otoacoustic emissions of mobile phone exposure
SO HEARING RESEARCH
LA English
DT Article
DE distortion product otoacoustic emissions; DPOAE generation mechanism;
mobile phone
ID ELECTROMAGNETIC-FIELDS; DPOAE; HEARING; WAVE
AB Mobile phones have become very commonly used throughout the world within a short period of time. Although there is no clear evidence to show harmful physiological effects of electromagnetic fields (EMF) at the levels used by mobile phones, there is widespread public concern that there may be potential for harm. Because mobile phones are usually held close to the ear, it is appropriate to study effects on hearing. In this study, the outer hair cell function of 15 subjects was assessed by DPOAE recording before and after a controlled EMF exposure. To increase the sensitivity of DPOAE recording to identify even small changes in hearing function, an inverse fast Fourier transform (IFFT) analysis and time-domain windowing was applied to separate the two generation mechanisms of DPOAE, the so-called place-fixed and wave-fixed mechanisms, in order to verify if EMF can affects the two DPOAE emission mechanisms. Statistical analysis of the data showed that 10 min of EMF exposure at the maximum power (2 W at 900 MHz or 1 W at 1800 MHz) does not induce any changes in either DPOAE generation mechanism. (c) 2005 Elsevier B.V. All rights reserved.
C1 CNR, ISIB, Ist Ingn Biomed, I-20133 Milan, Italy.
Univ Southampton, Inst Sound & Vibrat Res, Southampton SO9 5NH, Hants, England.
Natl Res Inst Radiobiol & Radiohyg, Dept Non Ionizing Radiat, Budapest, Hungary.
RP Parazzini, M (reprint author), CNR, ISIB, Ist Ingn Biomed, Piazza Leonardo Vinci 32, I-20133 Milan, Italy.
EM marta.parazzini@polimi.it
RI Parazzini, Marta/J-8175-2014; Tognola, Gabriella/B-9025-2015; Ravazzani,
Paolo/B-9139-2015
OI Parazzini, Marta/0000-0001-9008-7530; Ravazzani,
Paolo/0000-0003-0282-3329
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NR 23
TC 29
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 68
EP 78
DI 10.1016/j.heares.2005.04.013
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900006
PM 16054312
ER
PT J
AU Ton, C
Parng, C
AF Ton, C
Parng, C
TI The use of zebrafish for assessing ototoxic and otoprotective agents
SO HEARING RESEARCH
LA English
DT Article
DE ototoxicity; otoprotection; aminoglycoside; cisplatin; antioxidant; hair
cells; zebrafish
ID CISPLATIN-INDUCED OTOTOXICITY; HAIR CELL-DEATH; INDUCED
LIPID-PEROXIDATION; ROUND WINDOW APPLICATION; LATERAL-LINE SYSTEM;
INDUCED APOPTOSIS; D-METHIONINE; DANIO-RERIO;
AMINOGLYCOSIDE-OTOTOXICITY; INDIVIDUAL SENSITIVITY
AB Zebrafish and other fish exhibit hair cells in the lateral-fine neurornasts which Lire structurally and functionally similar to mammalian inner ear hair cells. To facilitate drug screening for ototoxic or otoprotective agents, we report a straightforward, quantitative in vivo assay to determine potential ototoxicity of drug candidates and to screen otoprotective agents in zebrafish larva. In this study, a fluorescent vital dye, DASPEI (2-(4-(dimetliylamino)styryl)-N-ethylpyridinium iodide), was used to stain zebrafish hair cells in vivo and morphometric analysis was performed to quantify fluorescence intensity and convert images to numerical endpoints. Various therapeutics, including gentamicin, cisplatin, vinblastine sulfate, quinine, and neomycin, which cause ototoxicity in humans, also resulted in hair cell loss in zebrafish. In addition, protection against cisplatin-induced ototoxicity was observed in zebrafish larva co-treated with cisplatin and different antioxidants including, ghutathione (GSH), allopurinol (ALO), N-acetyl L-cysteine (L-NAC), 2-oxothiazolidine-4-carboxylate (OTC) and D-methionine (D-MET). Our data indicate that results of ototoxicity and otoprotection in zebrafish correlated with results in humans, supporting use of zebrafish for preliminary drug screening. (c) 2005 Elsevier B.V. All rights reserved.
C1 Phylonix Pharmaceut Inc, Cambridge, MA 02139 USA.
RP Parng, C (reprint author), Phylonix Pharmaceut Inc, 100 Inman St, Cambridge, MA 02139 USA.
EM chuenlei@phylonix.com
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NR 88
TC 94
Z9 106
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 79
EP 88
DI 10.1016/j.heares.2005.05.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900007
PM 16014323
ER
PT J
AU Meinke, DK
Stagner, BB
Martin, GK
Lonsbury-Martin, BL
AF Meinke, DK
Stagner, BB
Martin, GK
Lonsbury-Martin, BL
TI Human efferent adaptation of DPOAEs in the L-1,L-2 space
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emission; DPOAE; adaptation; efferent
ID PRODUCT OTOACOUSTIC EMISSIONS; ACOUSTIC DISTORTION PRODUCTS;
AUDITORY-NERVE FIBERS; COCHLEAR MICROMECHANICAL PROPERTIES;
OLIVOCOCHLEAR-BUNDLE STIMULATION; CONTRALATERAL SOUND STIMULATION; OUTER
HAIR-CELLS; BROAD-BAND NOISE; ELECTRICAL-STIMULATION; VISUAL-ATTENTION
AB The adaptive properties of distortion product otoacoustic emissions (DPOAEs) at 2f(1) -f(2) were investigated in 12 ears of normally hearing adults aged 18-30 years using long-lasting 1-s primary-tone on-times. In this manner, DPOAE adaptation at a single f(2) of 1.55 kHz (f(2)/f(1) = 1.21) was evaluated as a function of the levels of the primary tones in a matrix of L-1,L-2 settings, which varied from 45 to 80 dB SPL, in 5-dB steps. DPOAEs were elicited under both monaural and binaural stimulus-presentation conditions. Adaptation was defined as the difference in DPOAE levels between the initial 92-ms baseline measure using a standard protocol and one obtained during the final 92 ms of the prolonged 1-s primary-tones. These differences were averaged across subjects to create contour plots of mean adaptation in the L-1,L-2 space. The 2f(1) -f(2) DPOAE revealed consistent regions of suppression (<=-0.5 dB difference) or enhancement (>= +0.5 dB difference) with respect to baseline measures within the L-1,L-2 matrix for both acoustic-stimulation conditions. Specifically, 2f(1) - f(2) DPOAE suppressions of 1-2 dB occurred for both monaural and binaural presentations, typically at level combinations in which L-1 > L-2 In contrast, larger 2f(1) - f(2) DPOAE enhancements of 3-4 dB occurred for only the binaural condition, at primary-tone level combinations where L-1 < L-2. Although adaptation activity was also evaluated for the DPOAEs at f(2) - f(1), 2f(2) - f(1), and 3f(1) - 2f(2), these emissions were either immeasurable (e.g., f(2) - f(1)) or only present in a subset of subjects over a narrow range of primary-tone frequencies and levels that did not support a systematic analysis. In summary, the 2f(1) - f(2) results suggest that a potentially important area for adaptation measures exists in the L-1,L-2 space, when L-1 is lower than L-2. This combination of primary-tone levels can lead to large DPOAE adaptation effects that may be related to a notch in the DPOAE response/growth or input/output (I/O) function. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Colorado, Dept Speech Language & Hearing Sci, Boulder, CO 80309 USA.
Jerry L Pettis Mem Vet Adm Med Ctr, Res Serv 151, Loma Linda, CA 92357 USA.
Loma Linda Univ, Dept Surg, Div Otolaryngol Head & Neck Surg, Loma Linda, CA 92350 USA.
RP Meinke, DK (reprint author), Univ No Colorado, Dept Commun Disorders, Campus Box 140, Greeley, CO 80639 USA.
EM deanna.meinke@unco.edu
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NR 59
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 89
EP 100
DI 10.1016/j.heares.2005.05.004
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900008
PM 16019174
ER
PT J
AU Morand-Villeneuve, N
Veuillet, E
Perrot, X
Lemoine, P
Gagnieu, MC
Sebert, P
Durrant, JD
Collet, L
AF Morand-Villeneuve, N
Veuillet, E
Perrot, X
Lemoine, P
Gagnieu, MC
Sebert, P
Durrant, JD
Collet, L
TI Lateralization of the effects of the benzodiazepine drug oxazepam on
medial olivocochlear system activity in humans
SO HEARING RESEARCH
LA English
DT Article
DE benzodiazepines; descending auditory pathways; medial olivocochlear
efferent bundle; left-right asymmetry; evoked otoacoustic emissions
ID COCHLEAR MICROMECHANICAL PROPERTIES; EVOKED OTOACOUSTIC EMISSIONS;
SUPERIOR OLIVARY COMPLEX; STEM AUDITORY NUCLEI; PIG BRAIN-STEM; INFERIOR
COLLICULUS; GUINEA-PIG; CORTICOFUGAL MODULATION; GABA-IMMUNOREACTIVITY;
RECEPTOR SUBTYPES
AB Benzodiazepines (Bzd) are known to interact with GABAergic inhibitory neurotransmission. Previous research on their effect on human auditory efferent pathways-through evoked otoacoustic emissions Suppression by contralateral acoustic stimulation (CAS)-indicated a decrease in medial olivocochlear (MOC) efferent system inhibitory activity, after oral intake of oxazepam - representative of the Bzd drug class. To date, this pharmacological effect was only assessed in the right ear. Since a leftward asymmetry of Bzd receptors localization in human auditory cortex has been described recently.. we explored in this study the hypothesis of an asymmetrical action of Bzd on MOC efferent functioning. The results revealed a significant difference of Bzd effect probing the right ear versus the left ear, with CAS-induced suppression being less effective in the right than left ear after oxazepam intake. This finding raises the question of possible neurochernical left-right asymmetry in the descending auditory pathways. The potential localization of this asymmetry is discussed. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Lyon 1, Hop Edouard Herriot, CNRS UMR 5020, Lab Neurosci & Syst Sensoriels, F-69366 Lyon 07, France.
Unite Clin Psychiat Biol, Bron, France.
Hop Edouard Herriot, Pharmacol Lab, Lyon, France.
Pharm CHS Vinatier, Bron, France.
Univ Pittsburgh, Dept Commun Sci & Disorders, Pittsburgh, PA 15260 USA.
Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15260 USA.
RP Veuillet, E (reprint author), Univ Lyon 1, Hop Edouard Herriot, CNRS UMR 5020, Lab Neurosci & Syst Sensoriels, 50 Av Tony Garnier,3 Pl Arsonval,Pavil U, F-69366 Lyon 07, France.
EM evelyne.veuillet@chu-lyon.fr
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NR 67
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 101
EP 106
DI 10.1016/j.heares.2005.05.003
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900009
PM 15993014
ER
PT J
AU Okamoto, Y
Nakagawa, S
Fujimoto, K
Tonoike, M
AF Okamoto, Y
Nakagawa, S
Fujimoto, K
Tonoike, M
TI Intelligibility of bone-conducted ultrasonic speech
SO HEARING RESEARCH
LA English
DT Article
DE ultrasonic hearing; bone conduction; speech intelligibility;
familiarity; confusion matrix
ID AUDITORY-CORTEX; PERCEPTION; HEARING
AB Ultrasound can be perceived through bone conduction by the profoundly deaf as well as by normal-hearing subjects. Moreover, speech signals modulated onto ultrasound can be detected through bone conduction. This study explored how well listeners can understand ultrasonic speech and the confusion patterns to evaluate and improve bone-conducted ultrasonic hearing. The intelligibility of Japanese words classified by familiarity and Japanese monosyllables with bone-conducted ultrasound was investigated. Results showed that the intelligibility of familiar words was higher than that of unfamiliar words. Further, the results of a monosyllable intelligibility test with bone-conducted ultrasound and those of a test with air-conducted sound showed a similar pattern of speech recognition with regard to the errors made. The relationship between speech intelligibility and sound level showed that the increase in the intelligibility of bone-conducted ultrasonic speech did not exceed the increase in the intelligibility of air-conducted speech as the sound level rose. (c) 2005 Elsevier B.V. All rights reserved.
C1 Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
Kumamoto Univ, Grad Sch Sci & Technol, Kumamoto 8608555, Japan.
RP Okamoto, Y (reprint author), Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, 1-8-31 Midorigaoka, Ikeda, Osaka 5638577, Japan.
EM yos-okamoto@aist.go.jp
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NR 21
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 107
EP 113
DI 10.1016/j.heares.2005.05.007
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900010
PM 16019175
ER
PT J
AU Rzadzinska, AK
Derr, A
Kachar, B
Noben-Trauth, K
AF Rzadzinska, AK
Derr, A
Kachar, B
Noben-Trauth, K
TI Sustained cadherin 23 expression in young and adult cochlea of normal
and hearing-impaired mice
SO HEARING RESEARCH
LA English
DT Article
DE age-related hearing loss; waltzer; cochlea; stereocilia; cadherin 23
ID MOUSE MODEL; INBRED STRAINS; FUNCTIONAL AGE; WALTZER MICE; STEREOCILIA;
CDH23; MUTATIONS; CELLS; PRESBYCUSIS; PATHOLOGY
AB Cadherin 23 encodes a single-pass transmembrane protein with 27 extracellular cadherin-domains and localizes to stereocilia where it functions as an inter-stereocilia link. Cadherin 23-deficient mice show congenital deafness in combination with circling behavior as a result of organizational defects in the stereocilia hair bundle, common inbred mouse strains carrying the hypornorphic Cdh23(753A) allele are highly susceptible to sensorineural hearing loss. Here, we show that an antibody (N1086) directed against the intracellular carboxyterminus reacts specifically with cadherin 23 and detects with high sensitivity the isoform devoid of the peptide encoded by exon 68 (CDH23 Delta 68). Cochlea, vestibule.. eye, brain and testis produce the CDH23 Delta 68 isoform in abundance and form moieties with different molecular weight due to variations in glycosylation content. In the cochlea, CDH23 Delta 68 expression is highest at postnatal day 1 (P1) and P7; expression is down regulated through P14 and P21 and persists at a low steady-state level throughout adulthood (P160). Furthermore, CDH23 Delta 68 expression levels in young and adult cochlea are similar among normal and hearing deficient strains (C3HeB/FeJ, C57BL/6J and BUB/BnJ). Finally, by immunofluorescence using an antibody (Pb240) specific for ecto-domain 14, we show that cadherin 23 localizes to stereocilia during hair bundle development in late gestation and early postnatal days. Cadherin 23-specific labeling becomes weaker as the hair bundle matures but faint labeling concentrated near the top of stereocilia is still detectable at P35. No labeling of cochlea stereocilia was observed with N1086. In conclusion, our data describe a cadherin 23-specific antibody with high affinity to the CDH23 Delta 68 isoform, reveal a dynamic cochlea expression and localization profile and show sustained cadherin 23 levels in adult cochlea of normal and hearing-impaired mice. (c) 2005 Elsevier B.V. All rights reserved.
C1 Natl Inst Deafness & Other Commun Disorders, Sect Struct Cell Biol, Lab Cellular Biol, NIH, Rockville, MD 20855 USA.
Natl Inst Deafness & Other Commun Disorders, Mol Biol Lab, Neurogenet Sect, Rockville, MD 20855 USA.
RP Noben-Trauth, K (reprint author), Natl Inst Deafness & Other Commun Disorders, Sect Struct Cell Biol, Lab Cellular Biol, NIH, Rockville, MD 20855 USA.
EM nobentk@nidcd.nih.gov
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NR 29
TC 28
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2005
VL 208
IS 1-2
BP 114
EP 121
DI 10.1016/j.heares.2005.05.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 977TA
UT WOS:000232824900011
PM 16005171
ER
PT J
AU Winer, JA
AF Winer, JA
TI Decoding the auditory corticofugal systems
SO HEARING RESEARCH
LA English
DT Article
DE auditory thalamus; inferior colliculus; corticofugal; corticothalamic;
corticocollicular; corticopontine
ID MEDIAL GENICULATE-BODY; SUPERIOR OLIVARY COMPLEX; COCHLEAR NUCLEUS;
FUNCTIONAL ARCHITECTURE; CORTICAL PROJECTIONS; INFERIOR COLLICULUS;
RESPONSE PROPERTIES; GUINEA-PIGS; LAYER V; CORTEX
AB The status of the organization of the auditory corticofugal systems is summarized. These are among the largest pathways in the brain, with descending connections to auditory and non-auditory thalamic, midbrain, and medullary regions. Auditory corticofugal influence thus reaches sites immediately presynaptic to the cortex, sites remote from the cortex, as in perolivary regions that may have a centrifugal role, and to the cochlear nucleus, which could influence early central events in hearing. Other targets include the striatum (possible premotor functions), the amygdala and central gray (prospective limbic and motivational roles), and the pontine nuclei (for precerebellar control). The size, specificity, laminar origins, and morphologic diversity of auditory corticofugal axons is consonant with an interpretation of multiple roles in parallel descending systems. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Calif Berkeley, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA.
RP Winer, JA (reprint author), Univ Calif Berkeley, Dept Mol & Cell Biol, Div Neurobiol, Room 289 Life Sci Addit, Berkeley, CA 94720 USA.
EM jaw@berkeley.edu
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NR 65
TC 37
Z9 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2005.06.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100001
PM 16091301
ER
PT J
AU Cousillas, H
Leppelsack, HJ
Leppelsack, E
Richard, JP
Mathelier, M
Hausberger, M
AF Cousillas, H
Leppelsack, HJ
Leppelsack, E
Richard, JP
Mathelier, M
Hausberger, M
TI Functional organization of the forebrain auditory centres of the
European starling: A study based on natural sounds
SO HEARING RESEARCH
LA English
DT Article
DE field L; neuronal selectivity; categorization; backward correlation;
mapping; starling
ID MALE ZEBRA FINCHES; FIELD-L-COMPLEX; WHITE-CROWNED SPARROW;
STURNUS-VULGARIS; CORTEX ANALOG; TAENOPYGIA-GUTTATA; RECEPTIVE-FIELDS;
SONG SYSTEM; NEURONS; NEOSTRIATUM
AB The field L complex is thought to be the highest auditory centre and the input in the song vocal nuclei. Different anatomical and functional subdivisions have been described in field L. Auditory neurons of field L are well activated by natural sounds and especially by species-specific sounds. A complex sound coding appears to exist in field L. However, until now, the spatial organization of the different functional subdivisions has been described only using artificial sounds. Here, we investigated the spatial distribution of neuronal responses in field L to species-specific songs. Starlings seemed to be a very appropriate species for this investigation, both because of their complex vocal behaviour that implies different levels of categorization and their neuronal responses towards complex song elements. Multi-unit recordings were performed in wild starlings that were awake. The method of backward correlation was used to visualize the functional organization and we represented the neuronal responses as both activity maps and correlation maps. The use of natural sounds allowed us to define several functional sub-areas with different neuronal processing. These results show that field L is involved in a more complex task than simple frequency processing. (c) 2005 Published by Elsevier B.V.
C1 Univ Rennes 1, CNRS, UMR 6552, F-35042 Rennes, France.
Tech Univ Munich, Inst Zool, D-85747 Garching, Germany.
RP Cousillas, H (reprint author), Univ Rennes 1, CNRS, UMR 6552, 263 Ave Gen Leclerc, F-35042 Rennes, France.
EM hugo.cousillas@univ-rennes1.fr
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NR 38
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 10
EP 21
DI 10.1016/j.heares.2005.01.008
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100002
PM 15996840
ER
PT J
AU Furness, DN
Katori, Y
Mahendrasingam, S
Hackney, CM
AF Furness, DN
Katori, Y
Mahendrasingam, S
Hackney, CM
TI Differential distribution of beta- and gamma-actin in guinea-pig
cochlear sensory and supporting cells
SO HEARING RESEARCH
LA English
DT Article
DE isoactins; actin filaments; auditory system; hair cells; stereocilia
ID OUTER HAIR-CELLS; INNER-EAR; IMMUNOFLUORESCENT LOCALIZATION; MOLECULAR
TREADMILL; CHINCHILLA COCHLEA; CROSS-LINKS; F-ACTIN; ORGAN; STEREOCILIA;
ISOFORMS
AB Sensory and supporting cells of the mammalian organ of Corti have cytoskeletons containing beta- and gamma-actin isoforms which have been described as having differing intracellular distributions in chick cochlear hair cells. Here, we have used post-embedding immunogold labelling for beta- and gamma-actin to investigate semiquantitatively how they are distributed in the guinea-pig cochlea and to compare different frequency locations. Amounts of beta-actin decrease and gamma-actin increase in the order, outer pillar cells, inner pillar cells, Deiters' cells and hair cells. There is also more beta-actin and less gamma-actin in outer pillar cells in higher than lower frequency regions. In hair cells, beta-actin is present in the cuticular plate but is more concentrated in the stereocilia, especially in the rootlets and towards the periphery of their shafts; labelling densities for gamma-actin differ less between these locations and it is the predominant isoform of the hair-cell lateral wall. Alignments of immunogold particles suggest beta-actin and gamma-actin form homomeric filaments. These data confirm differential distribution of these actin isoforms in the mammalian cochlea and reveal systematic differences between sensory and supporting cells. Increased expression of beta-actin in outer pillar cells towards the cochlear base may contribute to the greater stiffness of this region. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Keele, Sch Life Sci, MacKay Inst Commun & Neurosci, Keele ST5 5BG, Staffs, England.
Tohoku Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Sendai, Miyagi 9808574, Japan.
Univ Wisconsin, Dept Anat, Madison, WI 53706 USA.
RP Furness, DN (reprint author), Univ Keele, Sch Life Sci, MacKay Inst Commun & Neurosci, Keele ST5 5BG, Staffs, England.
EM coa14@keele.ac.uk
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NR 62
TC 24
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 22
EP 34
DI 10.1016/j.heares.2005.05.006
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100003
PM 16024192
ER
PT J
AU Bielefeld, EC
Hu, BH
Harris, KC
Henderson, D
AF Bielefeld, EC
Hu, BH
Harris, KC
Henderson, D
TI Damage and threshold shift resulting from cochlear exposure to
Paraquat-generated superoxide
SO HEARING RESEARCH
LA English
DT Article
DE Paraquat; superoxide; NADPH oxidase; cochlea
ID INDUCED HEARING-LOSS; OXYGEN SPECIES GENERATION; CISPLATIN OTOTOXICITY;
FREE-RADICALS; D-METHIONINE; HAIR-CELLS; INNER-EAR; GENTAMICIN EXPOSURE;
NOISE EXPOSURE; GUINEA-PIG
AB Superoxide has been implicated as a contributing factor to cochlear pathology from a number of sources, including noise and ototoxic drugs. The effects of NADPH oxidase-dependent superoxide on the cochlea were investigated in the current study using paraquat (PQ). PQ is a toxic herbicide that causes tissue damage by generating superoxide through reduction of molecular oxygen in a reaction catalyzed by NADPH oxidase. The current study examined the effects of round window PQ administration on inferior colliculus (IC) evoked potential thresholds (EVP) and hair cell damage. Using implanted IC electrodes, chinchillas were tested for IC EVP thresholds before and after PQ exposure. Ears were exposed to PQ at one of four concentrations: 10, 5, 3 mM, and vehicle control. Thresholds were increased in a dose-dependent manner, and peaked between one and seven days post-exposure. Thresholds then showed a small amount of recovery before reaching PTS by Day 22. Outer and inner hair cell losses were consistent with PTS. The similarities between PQ ototoxicity and noise-induced hearing loss suggest the possibility of similar biochemical pathways involving superoxide. (c) 2005 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Bielefeld, EC (reprint author), SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM ecb2@buffalo.edu
RI Bielefeld, Eric/D-2015-2012
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NR 50
TC 16
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 35
EP 42
DI 10.1016/j.heares.2005.03.025
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100004
PM 15935579
ER
PT J
AU Dalamon, V
Beheran, A
Diamante, F
Pallares, N
Diamante, V
Elgoyhen, AB
AF Dalamon, V
Beheran, A
Diamante, F
Pallares, N
Diamante, V
Elgoyhen, AB
TI Prevalence of GJB2 mutations and the del(GJB6-D13S1830) in Argentinean
non-syndromic deaf patients
SO HEARING RESEARCH
LA English
DT Article
DE deafness; GJB2; GJB6; c.35delG mutation; delGJB6-D13S1830; connexin 26;
connexin 30
ID CONNEXIN 26 GENE; GAP-JUNCTION CHANNELS; HEARING-LOSS; SENSORINEURAL
DEAFNESS; RECESSIVE DEAFNESS; DFNB1; EXPRESSION; FREQUENCY; CHILDREN
AB Genetically caused congenital deafness is a common trait affecting 1 in 2000 children and it is predominantly inherited in an autosomal recessive fashion. Several mutations in the GJB2 gene and a deletion of 342 kb in GJB6 (delGJB6-D13S1830) have been identified worldwide in patients with hearing impairment. The aim of this study was to determine the prevalence of these mutations in Argentina. Non-syndromic 46 probands (17 familial and 29 sporadic cases) were genetically evaluated. Mutations in GJB2 and/or delGJB6-D13S1830 were found in 19 patients, accounting for 41.3% of the sample. Of the 46 patients investigated in this study, 12 (26.1%) were diagnosed to carry sequence variations in both alleles; all but one, were considered causative for hearing impairment in those patients. In 7 out of 46 patients (15.2%) only one mutant allele was detected. of their 38 chromosomes, 71% resulted with mutations in the GJB2 gene and 11% in GJB6. The most frequent mutation in GJB2 (24%) was c.35delG(11% homozygous and 13% heterozygous and compound heterozygous). In addition, 11 sequence variations different from c.35delG, were identified in the coding region of the GJB2 gene: T8M, V27I, M34T, E47X, R75W, W77R, 182M, L90P, E129K, V1531, M163V. The delGJB6-D13S1830 mutation was found in 4 patients (9%), 3 of them associated with GJB2 mutations, resulting in compound heterozygous for the DFNB1 locus. The present study demonstrates that mutations in the GJB2 gene and the delGJB6-D13S1830 are prevalent in the Argentinean population. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Buenos Aires, Consejo Nacl Invest Cient & Tecn, Inst Invest Ingn Genet & Biol Mol, RA-1428 Buenos Aires, DF, Argentina.
Ctr Implantes Cocleares Prof Dr Vicente Diamante, RA-1028 Buenos Aires, DF, Argentina.
RP Dalamon, V (reprint author), Univ Buenos Aires, Consejo Nacl Invest Cient & Tecn, Inst Invest Ingn Genet & Biol Mol, Vuelta Obligado 2490, RA-1428 Buenos Aires, DF, Argentina.
EM dalamon@dna.uba.ar
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NR 34
TC 25
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 43
EP 49
DI 10.1016/j.heares.2005.04.012
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100005
PM 15964725
ER
PT J
AU Happich, M
von Lengerke, T
AF Happich, M
von Lengerke, T
TI Valuing the health state 'tinnitus': Differences between patients and
the general public
SO HEARING RESEARCH
LA English
DT Article
DE tinnitus valuation; patients; general public; standard gamble; time
trade-off
ID VISUAL ANALOG SCALES; QUALITY-OF-LIFE; PROSPECT-THEORY; STANDARD-GAMBLE;
PREFERENCES; UTILITIES; VALUES; RISK; CARE; MULTICENTER
AB Objective: In recent years, prioritisation in health care has gained increasing attention. However, rankings of interventions might depend on whom valuations of health states are elicited from. This paper's objective is to compare tinnitus. valuations by patients and the general public.
Methods: Groups of 210 patients and 210 adults not (currently) affected were interviewed to elicit valuations using visual analogue scale (VAS), time trade-off (TTO) and standard gamble (SG). MANOVA is used to test for group differences, controlling for sex and age.
Results: For all elicitation methods, valuations significantly differ in that patients report higher values than the general public respondents. Most notably, on the visual analogue scale which varies between 0 ('worst imaginable health') and 1 ('best imaginable health'), patients elicit a mean score of 0.54, and the general public 0.34 (those with former tinnitus experience) and 0.35 (without experience), respectively (F(2,377) = 55.67, p < 0.001). That is, patients valuate tinnitus as less severe than unaffected people.
Conclusion: As for other health states, tinnitus valuations differ depending on whether values of patients or the general public are elicited. These differences should be taken into account in health care evaluation and planning. (c) 2005 Elsevier B.V. All rights reserved.
C1 GSF, Natl Res Ctr Environm & Hlth, Inst Hlth Econ & Hlth Care Management, D-85758 Neuherberg, Germany.
Hannover Med Sch, D-30625 Hannover, Germany.
RP Happich, M (reprint author), GSF, Natl Res Ctr Environm & Hlth, Inst Hlth Econ & Hlth Care Management, POB 1129, D-85758 Neuherberg, Germany.
EM michael.happich@gsf.de
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NR 49
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 50
EP 58
DI 10.1016/j.heares.2005.04.002
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100006
PM 15919164
ER
PT J
AU Jeong, HJ
Hong, SH
Park, RK
Shin, T
An, NH
Kim, HM
AF Jeong, HJ
Hong, SH
Park, RK
Shin, T
An, NH
Kim, HM
TI Hypoxia-induced IL-6 production is associated with activation, of MAP
kinase, HIF-1, and NF-kappa B on HEI-OC1 cells
SO HEARING RESEARCH
LA English
DT Article
DE cochlear auditory cells; hypoxia; IL-6; MAPK; HIF-1 alpha; NF-kappa B
ID INDUCIBLE FACTOR-I; ENDOTHELIAL GROWTH-FACTOR; OXYGEN-SENSING
MECHANISMS; NECROSIS-FACTOR-ALPHA; DNA-BINDING ACTIVITY; NITRIC-OXIDE;
INNER-EAR; MESSENGER-RNA; SIGNAL-TRANSDUCTION; GENE-TRANSCRIPTION
AB In the present study, we investigated the signal transduction pathways of expression of IL-6 in the desferrioxamine (DFX)-stimulated cochlear auditory cell line, HEI-OC1 cells. DFX increased the expression of HIF-1 alpha and NF-kappa B in HEI-OC1 cells. DFX significantly increased the production of IL-6 (P < 0.05) and expression of IL-6 mRNA but did not affect TNF-alpha production. DFX also induced the activation of mitogen-activated protein kinase (MAPK) including p38, ER K, and JNK on HEI-OC1. Increased IL-6 by DFX was significantly inhibited by p38 inhibitor, SB203580 (about 72% inhibition, P = 0.027) but not ERK inhibitor, PD98059 or JNK inhibitor, SP600125. SB203580 inhibited the expression of IL-6 mRNA. Increased IL-6 production was partially inhibited by treatment of iron (HIF-1 inhibitor) or pyrriolidine-dithiocarbamate (PDTC, NF-kappa B inhibitor). DFX also induced IL-6 production and HIF-1 alpha expression in the inner ear. We demonstrated the regulatory effects of MAPK, HIF-1 alpha, and NF-kappa B on DFX-induced IL-6 production in a HEI-OC1 for the first time. In conclusion, these data indicate that regulation of inflammatory cytokine IL-6 by DFX, through mimicking hypoxic conditions, might explain its beneficial effect in the treatment of hypoxia-induced inner ear diseases. (c) 2005 Elsevier B.V. All rights reserved.
C1 Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea.
Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea.
Wonkwang Univ, Dept Microbiol & Immunol, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea.
Cheju Natl Univ, Inst Life Sci, Dept Vet Med, Cheju 690756, South Korea.
RP Kim, HM (reprint author), Kyung Hee Univ, Coll Oriental Med, 1 Hoegi Dong, Seoul 130701, South Korea.
EM hmkim@khu.ac.kr
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NR 50
TC 26
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 59
EP 67
DI 10.1016/j.heares.2005.04.003
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100007
PM 15913932
ER
PT J
AU Borko, R
Batta, TJ
Sziklai, I
AF Borko, R
Batta, TJ
Sziklai, I
TI Slow motility, electromotility and lateral wall stiffness in the
isolated outer hair cells
SO HEARING RESEARCH
LA English
DT Article
DE protein phosphorylation; cytoskeleton; ocadaic acid; inner ear
protective mechanism; protein phosphatase; cochlear amplifier
ID COCHLEAR AMPLIFIER; GUINEA-PIG; PROTEIN-KINASE; MOTOR PROTEIN;
RHO-KINASE; PHOSPHORYLATION; ACETYLCHOLINE; PHOSPHATASE; PRESTIN; ACTIN
AB Slow motile length changes of isolated, apical turn outer hair cells (OHCs) (n = 36) were induced by perfusion of saline (flow rate: 0.6 mu l/min) as a mechanical challenge or by perfusion of 12.5 mM KC1 solution for 90 s as a chemical and mechanical challenge with and without ocadaic acid (OA), a serine/threonine protein phosphatase inhibitor. Electromotility was evoked by square pulses from +/- 35 mV to +/- 240 mV during the slow shortening and recovery period (n = 36). Stiffness of the lateral wall was measured by the micropipette aspiration technique (n = 20).
Saline perfusion caused a reversible shortening of 774 +/- 87 nm (n = 9) as well as K+ of 1465 +/- 159 nm (n = 9). Slow shortening increased lateral wall stiffness (1.25 +/- 0.02 to 1.52 +/- 0.03 nN/mu m) (n = 5-5). Simultaneously, electromotility magnitude decreased (n = 9). Ocadaic acid blocked slow shortening, increased lateral wall stiffness, and decreased the magnitude of electromotility. Mechanical or mechanical + chemical stimulation of ocadaic acid treated OHCs do not further change stiffness or electromotility.
Isolated OHCs respond with slow shortening and consutive cell stiffness increase to mechanical insult. This phenomenon seems operating with calcium-, and phosphorylation-dependent modifications of the cytoskeletal proteins. The subsequent electromotility gain decrease suggests a slow OHC shortening driven regulation of the cochlear amplifier with simultaneous safety control of the auditory periphery against overstimulation. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Debrecen, ORL Clin, Hlth Sci Ctr, H-4012 Debrecen, Hungary.
RP Sziklai, I (reprint author), Univ Debrecen, ORL Clin, Hlth Sci Ctr, Nagyerderi Krt 98, H-4012 Debrecen, Hungary.
EM isziklai@jaguar.unideb.hu
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NR 43
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 68
EP 75
DI 10.1016/j.heares.2005.04.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100008
PM 15950414
ER
PT J
AU Withnell, RH
Dhar, S
Thomsen, A
AF Withnell, RH
Dhar, S
Thomsen, A
TI A comparison of OAEs arising from different generation mechanisms in
guinea pig
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emission; guinea pig; traveling wave; signal onset delay
ID PRODUCT OTOACOUSTIC EMISSIONS; BASILAR-MEMBRANE NONLINEARITY;
STIMULUS-FREQUENCY; FINE-STRUCTURE; TRAVELING WAVES; MODEL; PHASE;
COCHLEA; ORIGIN; DPOAE
AB Otoacoustic emissions provide unambiguous evidence that the cochlea supports energy propagation both towards, and away from, the stapes. The standard wave model for energy transport and cochlear mechanical amplification provides for compressional and inertial waves to transport this energy, the compressional wave through the fluids and the inertial wave along the basilar membrane via fluid coupling. It is generally accepted that energy propagation away from the stapes is dominated by a traveling wave mechanism along the basilar membrane. The mechanism by which energy is predominantly transported back to the stapes remains controversial. Here, we compared signal onset delay measurements and rise/steady-state/fall times for SFOAEs and 2f(1) - f(2) OAEs (f(2)/f(1) = 1.2) obtained using a pulsed-tone paradigm in guinea pig. Comparison of 2f(1) - f(2) OAE signal onset delay for the OAE arising from the f(2) region with SFOAE signal onset delay (matched to the f(2) stimulus frequency) based on signal onset occurring at 10% of the peak signal amplitude was suggestive of a bi-directional traveling wave mechanism. However, significant variability in signal onset delay and signal rise, steady-state duration, and fall times for both the 2f(1) - f(2) OAE and SFOAE was found, qualifying this interpretation. Such variability requires explanation, awaiting further studies. (c) 2005 Elsevier B.V. All rights reserved.
C1 Indiana Univ, Dept Speech & Hearing Sci, Bloomington, IN 47405 USA.
RP Withnell, RH (reprint author), Indiana Univ, Dept Speech & Hearing Sci, 200 S Jordan Ave, Bloomington, IN 47405 USA.
EM rwithnel@indiana.edu; s-dhar@northwestern.edu; athomsen@indiana.edu
RI Dhar, Sumitrajit/B-6319-2009
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NR 29
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 76
EP 86
DI 10.1016/j.heares.2005.04.005
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100009
PM 15935577
ER
PT J
AU Templin, T
Simmons, AM
AF Templin, T
Simmons, AM
TI Cellular and spatial changes in the anuran superior olive across
metamorphosis
SO HEARING RESEARCH
LA English
DT Article
DE stereology; cell counting; auditory; brainstem; Rana; tadpole
ID NEUROGLIAL CELLS OLIGODENDROCYTES; BULLFROG RANA-CATESBEIANA;
SPINAL-CORD; BRAIN-STEM; SEX-DIFFERENTIATION; ELECTRON-MICROSCOPY;
AUDITORY NUCLEI; GERM-CELLS; NUMBER; FROG
AB In many vertebrate species, the superior olive in the auditory brainstem plays an essential role in sound source localization. Little is known, however, about the structural and functional changes in this nucleus during development when alterations in head size and shape as well as in inner ear projections are expected to affect the perception of binaural cues. Using stereological techniques, we investigated the changes in several cellular and spatial features of the bullfrog superior olive across metamorphosis, the time period during which the animal transforms from a totally aquatic larva to a semiterrestrial adult. The total number of cells shows a strongly linear increase from hatchling through late larval stages. The number of neurons decreases during metamorphic climax stages, and recovers to pre-metamorphic climax levels in the early post-metamorphic froglet stage. The number of glial cells increases during the early larval period, and remains relatively stable, with no systematic variation, from late larval to froglet stages. The volume of the superior olive increases rapidly in early larval stages, followed by a much-attenuated rate of growth between late larval and froglet stages. These morphological changes may provide a substrate for the functional restructuring of the bullfrog superior olive, shortly before the switch from aquatic to mostly atmospheric hearing. (c) 2005 Elsevier B.V. All rights reserved.
C1 Brown Univ, Dept Psychol, Providence, RI 02912 USA.
Brown Univ, Dept Neurosci, Providence, RI 02912 USA.
RP Simmons, AM (reprint author), Brown Univ, Dept Psychol, Providence, RI 02912 USA.
EM andrea_simmons@brown.edu
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NR 52
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 87
EP 98
DI 10.1016/j.heares.2005.04.006
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100010
PM 15950413
ER
PT J
AU Harte, JM
Elliott, SJ
Kapadia, S
Lutman, ME
AF Harte, JM
Elliott, SJ
Kapadia, S
Lutman, ME
TI Dynamic nonlinear cochlear model predictions of click-evoked otoacoustic
emission suppression
SO HEARING RESEARCH
LA English
DT Article
DE cochlear mechanical nonlinearities; dynamic nonlinear model; nonlinear
interaction; otoacoustic emissions; suppression; click response
ID WIENER-KERNEL ANALYSIS; RELAXATION DYNAMICS; EXTERNAL TONES; TEMPORAL
INTERACTIONS; SINGLE-TONE; INNER-EAR; NOISE; INTENSITY; FEEDBACK;
HEARING
AB A comprehensive set of results from 2-click suppression experiments on otoacoustic emissions (OAEs) have been presented by Kapadia and Lutman [Kapadia, S., Lutman, M.E., 2000a. Nonlinear temporal interactions in click-evoked otoacoustic emissions. 1. Assumed model and polarity-symmetry. Hear. Res. 146, 89-100]. They found that the degree of suppression of an OAE evoked by a test click varied systematically with the timing and the level of a suppressor click, being greatest for suppressor clicks occurring some time before the test click, particularly at lower levels of suppression. Kapadia and Lutman also showed that although the general shape of the graph of suppression against suppressor click timing could be predicted by a static power law model, this did not predict the asymmetry with respect to the timing of the suppressor click. A generalised automatic gain control (AGC) is presented as a simple example of a dynamic nonlinear system. Its steady state nonlinear behaviour, as quantified by its level curve, and its dynamic behaviour, as quantified by its transient response, can be independently set by the feedback gain law and detector time constant, respectively. The previously reported suppression results, with the asymmetry in the timing, are found to be predicted better by such an AGC having a level curve with a slope of about 0.5 dB/dB, and a detector time constant of about twice the period at the characteristic frequency. Although this gives adequate predictions for high suppression levels, it under predicts the suppression and the asymmetry for lower levels. Further research is required to establish whether simple peripheral feedback models can explain OAE suppression of this type. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Southampton, Inst Sound & Vibrat Res, Southampton SO17 1BJ, Hants, England.
RP Harte, JM (reprint author), Univ Southampton, Inst Sound & Vibrat Res, Southampton SO17 1BJ, Hants, England.
EM jmh@isvr.soton.ac.uk
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NR 33
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 99
EP 109
DI 10.1016/j.heares.2005.04.008
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100011
PM 15935578
ER
PT J
AU Rivkin, AZ
Palacios, SD
Pak, K
Bennett, T
Ryan, AF
AF Rivkin, AZ
Palacios, SD
Pak, K
Bennett, T
Ryan, AF
TI The role of Fas-mediated apoptosis in otitis media: Observations in the
lpr/lpr mouse
SO HEARING RESEARCH
LA English
DT Article
DE otitis media; middle ear; Fas; Fas ligand; apoptosis
ID LIGAND-INDUCED APOPTOSIS; TUMOR-NECROSIS-FACTOR; MIDDLE-EAR MUCOSA;
EXPRESSION; LANGUAGE; EFFUSION; ANTIGEN; SPEECH
AB Apoptosis, or programmed cell death, is a critical regulatory mechanism involved in the function, homeostasis and stimulus response of many organ systems. In the middle ear, apoptosis could participate in mucosal remodeling or leukocyte clearance during otitis media (OM). Fas is a death receptor that can contribute to apoptosis in a variety of cell types. To assess the role of Fas signaling in OM, we probed for expression of Fas and Fas ligand (FasL) by polymerase chain reaction (PCR) during bacterial OM in the rat. In addition, we assessed the response of the middle ear to endotoxin, an inflammatory bacterial product that has been used as a model for otitis media in the mouse, in normal and Fas deficient mice. We saw evidence of increased expression of Fas and Fas ligand during bacterial OM. Moreover, the intensity of the mucosal response to endotoxin was significantly greater and the resolution of the response was prolonged in Fas deficient mice. Prolonged resolution of mucosal hyperplasia may reflect reduced apoptosis of the hyperplastic mucosal cells. Elucidation of the pathways that regulate the mucosal hyperplastic response during otitis media brings us closer to manipulating them in the interest of reducing the chronic complications of this disease. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Calif San Diego, Sch Med, Div Otolaryngol, Dept Surg, La Jolla, CA 92093 USA.
VA Med Ctr, La Jolla, CA 92093 USA.
RP Ryan, AF (reprint author), Univ Calif San Diego, Sch Med, Div Otolaryngol, Dept Surg, 9500 Gilman Dr 0666,Fir Bldg,Room 106, La Jolla, CA 92093 USA.
EM aryan@ucsd.edu
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NR 21
TC 9
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2005
VL 207
IS 1-2
BP 110
EP 116
DI 10.1016/j.heares.2005.04.010
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 970OS
UT WOS:000232320100012
PM 15978756
ER
PT J
AU Schofield, BR
Coomes, DL
AF Schofield, BR
Coomes, DL
TI Projections from auditory cortex contact cells in the cochlear nucleus
that project to the inferior colliculus
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE auditory system; descending pathways; efferent
ID SUPERIOR OLIVARY COMPLEX; GUINEA-PIG; CORTICOFUGAL MODULATION; RAT;
DORSAL; SYSTEM; CAT; PATHWAYS; PATTERNS; MIDBRAIN
AB Anterograde and retrograde tracing techniques were combined to determine whether auditory cortical axons contact cells in the cochlear nucleus that project to the inferior colliculus. FluoroRuby or fluorescein dextran was injected into auditory cortex to label cortical axons by anterograde transport. Different fluorescent tracers (Fast Blue, FluoroGold, FluoroRuby or fluorescein dextran) were injected into one or both inferior colliculi to label cells in the cochlear nucleus. After 12-15 days, the brain was processed for fluorescence microscopy and the cochlear nuclei were examined for apparent contacts between cortical axons and retrogradely labeled cochlear nucleus cells. The results suggest that axons from the ipsilateral or contralateral cortex contact fusiform and giant cells in the dorsal cochlear nucleus and multipolar cells in the ventral cochlear nucleus that project directly to the inferior colliculus. The contacts occur on cell bodies and dendrites. The target cells in the cochlear nucleus include cells that project ipsilaterally, contra-laterally or bilaterally to the inferior colliculus. The results suggest that auditory cortex is in a position to exert direct effects on the monaural pathways that ascend from the cochlear nucleus. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Louisville, Dept Anat Sci & Neurobiol, Louisville, KY 40202 USA.
RP Schofield, BR (reprint author), Univ Louisville, Dept Anat Sci & Neurobiol, 500 S Preston St, Louisville, KY 40202 USA.
EM brscho0l@gwise.louisville.edu
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NR 36
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 3
EP 11
DI 10.1016/j.heares.2005.03.005
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100002
PM 16080994
ER
PT J
AU Cant, NB
Benson, CG
AF Cant, NB
Benson, CG
TI An atlas of the inferior colliculus of the gerbil in three dimensions
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE auditory system; brain atlas; gerbil; inferior colliculus; neuroanatomy
ID DORSAL COCHLEAR NUCLEUS; CYTOCHROME-OXIDASE HISTOCHEMISTRY; SUPERIOR
OLIVARY NUCLEUS; SINGLE-UNIT RESPONSES; AUDITORY-SYSTEM; DESCENDING
PROJECTIONS; ASCENDING PROJECTIONS; EFFERENT PROJECTIONS; CAT; RAT
AB An atlas of the inferior colliculus of the gerbil is presented in three dimensions. Sections were cut in the transverse (coronal), horizontal or saggital planes and fit to a common cartesian coordinate grid. The sections used for the atlas were reacted for cytochrome oxidase activity, a functional marker that can be used to distinguish different areas in the brainstem. The atlas can be used for representation, comparison and correlation of neuro anatomical, neurophysiological, neurochemical and other data that can be spatially mapped in the inferior colliculus. (c) 2005 Elsevier B.V. All rights reserved.
C1 Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA.
RP Cant, NB (reprint author), Duke Univ, Med Ctr, Dept Neurobiol, POB 3209, Durham, NC 27710 USA.
EM nellcant@neuro.duke.edu
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NR 47
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 12
EP 27
DI 10.1016/j.heares.2005.02.014
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100003
PM 16080995
ER
PT J
AU Tong, L
Altschuler, RA
Holt, AG
AF Tong, L
Altschuler, RA
Holt, AG
TI Tyrosine hydroxylase in rat auditory midbrain: Distribution and changes
following deafness
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE hearing; deafness; dopamine; cochlear ablation; Sprague Dawley rats
ID MONOAMINE NEURON SYSTEMS; INFERIOR COLLICULUS; BRAIN-STEM; COCHLEAR
NUCLEUS; PLASTICITY; PROJECTIONS; IMMUNOREACTIVITY; LOCALIZATION;
INHIBITION; RECEPTORS
AB Tyrosine hydroxylase (TH), a key enzyme in the catecholaminergic pathway, allows for the differentiation of dopaminergic neurons. We previously showed decreases in TH gene expression in the rat inferior colliculus (IC) 3 and 21 days following deafness. In the present study, we characterized the normal distribution of TH as well as changes following deafness (bilateral cochlear ablation) in the IC and nuclei of the lateral lemniscus. Immunostaining was compared in three groups of rats: normal hearing (n = 8), 21 day deaf (n = 5) and 90 days following deafening (n = 5). Many TH immunoreactive fibers and puncta were identified in the IC and nuclei of the lateral lemniscus of normal hearing animals and labeling was most dense in the external cortex of the IC. We also identified immunolabeling for fibers and puncta for another catecholaminergic enzyme, dopamine beta hydroxylase (DBH), but not phenylethanolamine-N-methyltranferase (PNMT). Neurons immunopositive for TH but not DBH or PNMT were observed in the dorsal cortex and dorsal horn of the central nucleus of the IC and ventral and intermediate lemniscus. In the central nucleus of the IC and dorsal lateral lemniscus many lightly labeled TH neurons were also DBH positive. Although the number of immunopositive cells in the IC and lemniscus declined 3 weeks and 3 months after deafening, the decline was not significant at three weeks in the VNLL nor after three months in the dorsal cortex. Immunolabeling for TH decreased significantly in IC and lemniscus 3 weeks and 3 months following deafening. These results suggest a role for dopaminergic neurons and fibers in deafness-related plasticity. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Dept Otolaryngol Head & Neck Surg, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA.
RP Holt, AG (reprint author), Univ Michigan, Dept Otolaryngol Head & Neck Surg, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM avrilhol@umich.edu
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NR 44
TC 14
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 28
EP 41
DI 10.1016/j.heares.2005.03.006
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100004
PM 16080996
ER
PT J
AU Cramer, KS
AF Cramer, KS
TI Eph proteins and the assembly of auditory circuits
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE auditory pathways; auditory nerve; axon guidance; Eph receptor; ephrin
ID MEDIAL SUPERIOR OLIVE; INTERAURAL TIME DIFFERENCES; RECEPTOR TYROSINE
KINASES; CHICK BRAIN-STEM; MOUSE INNER-EAR; COCHLEAR GANGLION;
TRANSMEMBRANE LIGANDS; RETINOTECTAL SYSTEM; HIPPOCAMPAL AXONS; TRAPEZOID
BODY
AB Many kinds of information are carried in the acoustic signal that reaches auditory receptor cells in the cochlea. The analysis of this information is possible in large part because of the neuronal architecture of the auditory system. The mechanisms that establish the precise circuitry that underlies auditory processing have not yet been identified. The Eph receptor tyrosine kinases and their ligands are proteins that regulate axon guidance and have been shown to contribute to the establishment of topographic projections in several areas of the nervous system. Several studies have begun to investigate whether these proteins are involved in the formation of auditory system connections. Studies of gene expression show that Eph proteins are extensively expressed in structures of the inner ear as well as in neurons in the peripheral and central components of the auditory system. Functional studies have demonstrated that Eph signaling influences the assembly of auditory pathways. These studies suggest that Eph protein signaling has a significant role in the formation of auditory circuitry. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA.
RP Cramer, KS (reprint author), Univ Calif Irvine, Dept Neurobiol & Behav, 2205 McGaugh Hall, Irvine, CA 92697 USA.
EM cramerk@uci.edu
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NR 83
TC 38
Z9 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 42
EP 51
DI 10.1016/j.heares.2004.11.024
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100005
PM 16080997
ER
PT J
AU Fritzsch, B
Pauley, S
Matel, V
Katz, DM
Xiang, MQ
Tessarollo, L
AF Fritzsch, B
Pauley, S
Matel, V
Katz, DM
Xiang, MQ
Tessarollo, L
TI Mutant mice reveal the molecular and cellular basis for specific sensory
connections to inner ear epithelia and primary nuclei of the brain
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE ear sensory neurons; vestibular neurons; spiral ganglia; pathfinding;
neurotropins
ID BACTERIAL ARTIFICIAL CHROMOSOME; HAIR-CELLS; NEUROTROPHIC FACTOR; SYSTEM
DEVELOPMENT; STATOACOUSTIC NEURONS; POSTNATAL REFINEMENT; FATE
DETERMINATION; AUDITORY-SYSTEM; NERVOUS-SYSTEM; HEARING-LOSS
AB We review the in vivo evidence for afferent fiber guidance to the inner ear sensory epithelia and the central nuclei of termination. Specifically, we highlight our current molecular understanding for the role of hair cells and sensory epithelia in guiding afferents, how disruption of certain signals can alter fiber pathways, even in the presence of normal hair cells, and what role neurotrophins play in fiber guidance of sensory neurons to hair cells. The data suggest that the neurotrophin BDNF is the most important molecule known for inner ear afferent fiber guidance to hair cells in vivo. This suggestion is based on experiments on Ntf3 transgenic mice expressing BDNF under Ntf3 promoter that show deviations of fiber growth in the ear to areas that express BDNF but have no hair cells. However, fiber growth can occur in the absence of BDNF as demonstrated by double mutants for BDNF and Bax. We directly tested the significance of hair cells or sensory epithelia for fiber guidance in mutants that lose hair cells (Pou4f3) or do not form a posterior crista (Fgf10). While these data emphasize the role played by BDNF, normally released from hair cells, there is some limited capacity for directed growth even in the absence of hair cells, BDNF, or sensory epithelia. This directed growth may rely on semaphorins or other matrix proteins because targeted ablation of the sema3 docking site on the sema receptor Npn1 results in targeting errors of fibers even in the presence of hair cells and BDNF. Overall, our data support the notion that targeting of the afferent processes in the ear is molecularly distinct from targeting processes in the central nuclei. This conclusion is derived from data that show no recognizable central projection deviation, even if fibers are massively rerouted in the periphery, as in Ntf3(tgBDNF) mice in which vestibular fibers project to the cochlea. (c) 2005 Elsevier B.V. All rights reserved.
C1 Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA.
RP Fritzsch, B (reprint author), Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA.
EM fritzsch@creighton.edu
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NR 73
TC 35
Z9 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 52
EP 63
DI 10.1016/j.heares.2004.11.025
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100006
PM 16080998
ER
PT J
AU Godfrey, DA
Godfrey, MA
Ding, DL
Chen, KJ
Salvi, RJ
AF Godfrey, DA
Godfrey, MA
Ding, DL
Chen, KJ
Salvi, RJ
TI Amino acid concentrations in chinchilla cochlear nucleus at different
times after carboplatin treatment
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE auditory; ototoxicity; aspartate; glutamate; gamma-aminobutyrate;
glycine
ID HAIR CELL LOSS; AUDITORY-NERVE LESION; ASPARTIC-ACID; GLUTAMIC-ACID;
BRAIN-STEM; INNER; DEGENERATION; OTOTOXICITY; MAGNITUDE; CHILDREN
AB Amino acid concentrations were measured in the cochlear nucleus for a group of 20 chinchillas: four each of control and 4, 8, 29, and 85 days after treatment with the ototoxic anti-tumor drug carboplatin (100mg/kg, i.p.). The treated chinchillas showed various extents of inner hair cell loss, generally more complete at longer survival times, but little loss of outer hair cells. Aspartate concentration in rostral anteroventral cochlear nucleus (AVCN) showed a decline to 28% less than the control value at 29 and 85 days after treatment, whereas glutamate concentration showed little change through 29 days, then dropped by 22% at 85 days after treatment. In caudal posteroventral cochlear nucleus (PVCN), the aspartate concentration decreased by 32% at 29 days, in animals with significant inner hair cell loss, and 48% at 85 days after treatment, while the glutamate concentration showed no decrease through 29 days and 40% decrease at 85 days. The concentration of gamma-aminobutyrate (GABA) was about 18% lower than control in caudal PVCN at all survival times. Significant correlations were found between the proportion of inner hair cells remaining and glutamate and aspartate concentrations in PVCN and AVCN, but not GABA or other amino acids. (c) 2005 Elsevier B.V. All rights reserved.
C1 Med Coll Ohio, Dept Surg, Div Otolaryngol, Toledo, OH 43614 USA.
SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
RP Godfrey, DA (reprint author), Med Coll Ohio, Dept Surg, Div Otolaryngol, 3065 Arlington Ave, Toledo, OH 43614 USA.
EM dgodfrey@mco.edu
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NR 35
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 64
EP 73
DI 10.1016/j.heares.2005.03.004
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100007
PM 16080999
ER
PT J
AU Morley, BJ
AF Morley, BJ
TI Nicotinic cholinergic intercellular communication: Implications for the
developing auditory system
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE developing auditory brainstem; nicotinic acetylcholine receptors;
calcium permeability; gene expression; nicotine; language development
ID CENTRAL-NERVOUS-SYSTEM; ACETYLCHOLINE-RECEPTOR SUBUNIT;
ALPHA-BUNGAROTOXIN BINDING; SUPERIOR OLIVARY COMPLEX; IN-SITU
HYBRIDIZATION; EXCITATORY SYNAPTIC-TRANSMISSION; ACETYLTRANSFERASE
MESSENGER-RNA; ALTERNATIVE SPLICE VARIANT; VENTRAL COCHLEAR NUCLEUS; RAT
SENSORY CORTEX
AB In this paper, research on the temporal and spatial distribution of cholinergic-related molecules in the lower auditory brainstem, with an emphasis on nicotinic acetylcholine receptors (nAChRs), is reviewed. The possible functions of acetylcholine (ACh) in driving selective auditory neurons before the onset of hearing, inducing glutamate receptor gene expression, synaptogenesis, differentiation, and cell survival are discussed. Experiments conducted in other neuronal and non-neuronal systems are drawn on extensively to discuss putative functions of ACh and nAChRs. Data from other systems may provide insight into the functions of ACh and nAC-hRs in auditory processing. The mismatch of presynaptic and postsynaptic markers and novel endogenous agonists of nAChRs are discussed in the context of non-classical interneuronal communication. The molecular mechanism that may underlie the many functions of ACh and its agonists is the regulation of intracellular calcium through nAChRs. The possible reorganization that may take place in the auditory system by the exposure to nicotine during critical developmental periods is also briefly considered. (c) 2005 Elsevier B.V. All rights reserved.
C1 Boys Town Natl Res Hosp, Neurochem Lab, Omaha, NE 68131 USA.
RP Morley, BJ (reprint author), Boys Town Natl Res Hosp, Neurochem Lab, 555 N 30th St, Omaha, NE 68131 USA.
EM morley@boystown.org
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NR 215
TC 8
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 74
EP 88
DI 10.1016/j.heares.2005.02.012
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100008
PM 16081000
ER
PT J
AU Kamke, MR
Brown, M
Irvine, DRF
AF Kamke, MR
Brown, M
Irvine, DRF
TI Origin and immunolesioning of cholinergic basal forebrain innervation of
cat primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE AI; acetylcholine; immunohistochemistry; immunotoxin; retrograde
ID RECEPTIVE-FIELD PLASTICITY; TONE-EVOKED RESPONSES; 192 IGG-SAPORIN;
NUCLEUS BASALIS; HORSERADISH-PEROXIDASE; RETROGRADE TRANSPORT;
INTRAPARENCHYMAL INFUSIONS; TONOTOPIC ORGANIZATION; CORTICAL
PROJECTIONS; MUSCARINIC AGONISTS
AB Numerous studies have implicated the cholinergic basal forebrain (cBF) in the modulation of auditory cortical responses. This study aimed to accurately define the sources of cBF input to primary auditory cortex (AI) and to assess the efficacy of a cholinergic immunotoxin in cat. Three anaesthetized cats received multiple injections of horseradish-peroxidase conjugated wheatgerm-agglutin into physiologically identified AI. Following one to two days survival, tetramethylbenzidine histochemistry revealed the greatest number of retrogradely labeled cells in ipsilateral putamen, globus pallidus and internal capsule, and smaller numbers in more medial nuclei of the basal forebrain (BF). Concurrent choline acetyltransferase immunohistochemistry showed that almost 80% of the retrogradely labeled cells in BE were cholinergic, with the vast majority or these cells arising from the more lateral BE nuclei identified above. In the second part of the study, unilateral intraparenchymal injections of the cholinergic immunotoxin ME20.4-SAP were made into the putamen/globus pallidus nuclei of six cats. Immuno- and histochemistry revealed a massive reduction in the number of cholinergic cells in and around the targeted area, and a corresponding reduction in the density of cholinergic fibers in auditory cortex. These results are discussed in terms of their implications for investigations of the role of the cBF in cortical plasticity. (c) 2005 Elsevier B.V. All rights reserved.
C1 Monash Univ, Fac Med Nursing & Hlth Sci, Dept Psychol, Sch Psychol Psychiat & Psychol Med, Clayton, Vic 3800, Australia.
RP Kamke, MR (reprint author), Monash Univ, Fac Med Nursing & Hlth Sci, Dept Psychol, Sch Psychol Psychiat & Psychol Med, Clayton, Vic 3800, Australia.
EM Marc.Kamke@med.monash.edu.au
RI Irvine, Dexter/F-7474-2011; Kamke, Marc/J-4059-2014
OI Kamke, Marc/0000-0003-0248-9682
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NR 56
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 89
EP 106
DI 10.1016/j.heares.2004.12.014
PG 18
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100009
PM 16081001
ER
PT J
AU Vale, C
Caminos, E
Martinez-Galan, JR
Juiz, JM
AF Vale, C
Caminos, E
Martinez-Galan, JR
Juiz, JM
TI Expression and developmental regulation of the K(+)-Cl(-) cotransporter
KCC2 in the cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE GABA; glycine; inhibition; chloride transport; development; auditory;
brain stem
ID INHIBITORY SYNAPTIC-TRANSMISSION; NEURONAL-SPECIFIC ISOFORM; DORSAL HORN
NEURONS; BRAIN-STEM; RAT-BRAIN; INTRACELLULAR CHLORIDE; INFERIOR
COLLICULUS; HIPPOCAMPAL-NEURONS; EXCITATORY ACTIONS; PYRAMIDAL NEURONS
AB KCC2 is a neuron-specific Cl(-) transporter whose role in adult central neurons is to maintain low intracellular Cl(-) concentrations and, therefore, generate an inward-directed electrochemical gradient for Cl(-) needed for the hyperpolarizing responses to the inhibitory amino acids GABA and glycine. We report that the KCC2 protein is intensely expressed in CN neurons and preferentially associated with plasma membrane domains, consistent with GABA and glycinergic-mediated inhibition in this auditory nucleus. Postnatal KCC2 expression and distribution patterns are similar in developing and adult CN neurons and do not match the time course of GABergic or glycinergic synaptogenesis. Therefore, in the CN, neither KCC2 protein upregulation nor progressive integration in the plasma membrane seem to be involved in KCC2 developmental regulation. Considering that GABA and glycine are depolarizing during early postnatal development, it is conceivable that KCC2 is in place but inactive during early postnatal development in the CN and becomes active as inhibitory synaptogenesis proceeds. This notion is supported by the finding that the phosphorylation state of KCC2 differs from developing to adult CN, with the phosphorylated form predominating in the latter. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Castilla La Mancha, Sch Med, Albacete 02005, Spain.
Univ Castilla La Mancha, Ctr Reg Invest Biomed, Albacete 02005, Spain.
RP Juiz, JM (reprint author), Univ Castilla La Mancha, Sch Med, Campus Albacete, Albacete 02005, Spain.
EM JoseManuel.Juiz@uclm.es
RI Vale, Carmen/L-5287-2014; Caminos, Elena/F-2612-2015
OI Vale, Carmen/0000-0002-9842-6223; Caminos, Elena/0000-0003-1538-2366
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NR 53
TC 24
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 107
EP 115
DI 10.1016/j.heares.2005.03.012
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100010
PM 16081002
ER
PT J
AU Brew, HM
Forsythe, ID
AF Brew, HM
Forsythe, ID
TI Systematic variation of potassium current amplitudes across the
tonotopic axis of the rat medial nucleus of the trapezoid body
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE potassium; channel; capacitance; MNTB; tonotopic
ID LATERAL SUPERIOR OLIVE; STEM AUDITORY NUCLEI; ANTEROVENTRAL COCHLEAR
NUCLEUS; MOUSE-BRAIN SLICE; K+ CHANNELS; DIFFERENTIAL EXPRESSION;
PRINCIPAL CELLS; HAIR-CELLS; NEURONS; TIME
AB Many central auditory nuclei preserve the tonotopic organization of their afferent inputs, generating a frequency "map" across the nucleus. In the medial nucleus of the trapezoid body (MNTB) the most medial neurons receive inputs corresponding to the highest frequency sounds and the most lateral neurons have the lowest characteristic frequencies. Whole-cell patch recording from MNTB principal neurons in rat brainstem slices demonstrates a corresponding tonotopic organization of voltage-gated outward potassium currents. Medial MNTB neurons had larger total outward K+ current amplitudes than lateral neurons and similar medial to-lateral gradients were observed for two K+ current subtypes distinguished by their low and high voltage activation thresholds. In contrast, a third K+ conductance with an intermediate voltage threshold and slower kinetics showed an inverse gradient (being smallest in medial NINTB). The orthogonal axes of NINTB did not exhibit potassium current gradients (dorsal-to-ventral, or rostral-to-caudal). The input resistance was unchanged across the MNTB, but a slow capacitative component was enhanced in lateral neurons. These data demonstrate that the intrinsic properties of rat MNTB neurons are tuned across the tonotopic axis so as to promote shorter action potentials, faster firing and therefore greater accuracy in transmission of auditory information in the high characteristic frequency regions. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Leicester, Dept Cell Physiol & Pharmacol, Leicester LE1 9HN, Leics, England.
Univ Washington, Dept Otolaryngol Head & Neck Surg, Virginia Merill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA.
RP Brew, HM (reprint author), Univ Leicester, Dept Cell Physiol & Pharmacol, POB 138, Leicester LE1 9HN, Leics, England.
EM hbrew@u.washington.edu; idf@le.ac.uk
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NR 61
TC 29
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 116
EP 132
DI 10.1016/j.heares.2004.12.012
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100011
PM 16081003
ER
PT J
AU Kaczmarek, LK
Bhattacharjee, A
Desai, R
Gan, L
Song, P
von Hehn, CAA
Whim, MD
Yang, B
AF Kaczmarek, LK
Bhattacharjee, A
Desai, R
Gan, L
Song, P
von Hehn, CAA
Whim, MD
Yang, B
TI Regulation of the timing of MNTB neurons by short-term and long-term
modulation of potassium channels
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
ID CENTRAL-NERVOUS-SYSTEM; FREQUENCY FIRING NEURONS; AUDITORY NEURONS;
TRAPEZOID BODY; MEDIAL NUCLEUS; K+ CHANNEL; COCHLEAR NUCLEUS; OUTWARD
CURRENTS; DIFFERENTIAL EXPRESSION; BRAIN-STEM
AB The firing patterns of neurons in central auditory pathways encode specific features of sound stimuli, such as frequency, intensity and localization in space. The generation of the appropriate pattern depends, to a major extent, on the properties of the voltage-dependent potassium channels in these neurons. The mammalian auditory pathways that compute the direction of a sound source are located in the brainstem and include the connection from bushy cells in the anteroventral cochlear nucleus (AVCN) to the principal neurons of the medial nucleus of the trapezoid body (MNTB). To preserve the fidelity of timing of action potentials that is required for Sound localization, these neurons express several types of potassium channels, including the Kv3 and Kv1 families of voltage-dependent channels and the Slick and Slack sodium-dependent channels. These channels determine the pattern of action potentials and the amount of neurotransmitter released during repeated stimulation. The amplitude of currents carried by one of these channels, the Kv3.1b channel, is regulated in the short term by protein phosphorylation, and in the long term, by changes in gene expression, such that the intrinsic excitability of the neurons is constantly being regulated by the ambient auditory environment. (c) 2005 Elsevier B.V. All rights reserved.
C1 Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA.
Univ Calif San Francisco, Dept Neurol, Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA.
Penn State Univ, Dept Biol, State Coll, PA 16802 USA.
RP Kaczmarek, LK (reprint author), Yale Univ, Sch Med, Dept Pharmacol, 333 Cedar St, New Haven, CT 06520 USA.
EM leonard.kaczmarck@yale.edu
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NR 72
TC 40
Z9 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 133
EP 145
DI 10.1016/j.heares.2004.11.023
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100012
PM 16081004
ER
PT J
AU Metherate, R
Kaur, S
Kawai, H
Lazar, R
Liang, K
Rose, HJ
AF Metherate, R
Kaur, S
Kawai, H
Lazar, R
Liang, K
Rose, HJ
TI Spectral integration in auditory cortex: Mechanisms and modulation
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE thalamocortical; intracortical; acetylcholine; receptive field;
intracellular; synapse
ID FREQUENCY RECEPTIVE-FIELDS; CAT VISUAL-CORTEX; THALAMOCORTICAL SYNAPTIC
TRANSMISSION; COCHLEAR NUCLEUS NEURONS; VOLTAGE-CLAMP ANALYSIS;
GUINEA-PIG; IN-VIVO; RESPONSE PROPERTIES; SINGLE NEURONS; CHOLINERGIC
MODULATION
AB Auditory cortex contributes to the processing and perception of spectro temporally complex stimuli. However, the mechanisms by which this is accomplished are not well understood. In this review, we examine evidence that single cortical neurons receive input covering much of the audible spectrum. We then propose an anatomical framework by which spectral information converges on single neurons in primary auditory cortex, via a combination of thalamocortical and intracortical "horizontal" pathways. By its nature, the framework confers sensitivity to specific, spectrotemporally complex stimuli. Finally, to address how spectral integration can be regulated, we show how one neuromodulator, acetylcholine, could act within the hypothesized framework to alter integration in single neurons. The results of these studies promote a cellular understanding of information processing in auditory cortex. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA.
RP Metherate, R (reprint author), Univ Calif Irvine, Dept Neurobiol & Behav, 2205 McGaugh Hall, Irvine, CA 92697 USA.
EM rmethera@uci.edu
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NR 135
TC 55
Z9 56
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 146
EP 158
DI 10.1016/j.heares.2005.01.014
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100013
PM 16081005
ER
PT J
AU Fritz, J
Elhilali, M
Shamma, S
AF Fritz, J
Elhilali, M
Shamma, S
TI Active listening: Task-dependent plasticity of spectrotemporal receptive
fields in primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE auditory; cortex; plasticity; attention; adaptive; behavior
ID PRIMARY VISUAL-CORTEX; PUPILLARY CONDITIONED-RESPONSE; PRIMARY
SOMATOSENSORY CORTEX; SINGLE-UNIT RESPONSES; WAKING GUINEA-PIG;
PHYSIOLOGICAL PLASTICITY; TEMPORAL PLASTICITY; NUCLEUS BASALIS;
REPRESENTATIONAL PLASTICITY; CORTICAL REORGANIZATION
AB Listening is an active process in which attentive focus on salient acoustic features in auditory tasks can influence receptive field properties of cortical neurons. Recent studies showing rapid task-related changes in neuronal spectroternporal receptive fields (STRFs) in primary auditory cortex of the behaving ferret are reviewed in the context of current research on cortical plasticity. Ferrets were trained on spectral tasks, including tone detection and two-tone discrimination, and on temporal tasks, including gap detection and click-rate discrimination. STRF changes could be measured on-line during task performance and occurred within minutes of task onset. During spectral tasks, there were specific spectral changes (enhanced response to tonal target frequency in tone detection and discrimination, suppressed response to tonal reference frequency in tone discrimination). However, only in the temporal tasks, the STRF was changed along the temporal dimension by sharpening temporal dynamics. In ferrets trained on multiple tasks, distinctive and task-specific STRF changes could be observed in the same cortical neurons in successive behavioral sessions. These results suggest that rapid task-related plasticity is an ongoing process that occurs at a network and single unit level as the animal switches between different tasks and dynamically adapts cortical STRFs in response to changing acoustic demands. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Maryland, Ctr Auditory & Acoust Res, College Pk, MD 20742 USA.
RP Fritz, J (reprint author), Univ Maryland, Ctr Auditory & Acoust Res, College Pk, MD 20742 USA.
EM ripple@isr.umd.edu
RI Elhilali, Mounya/A-3396-2010; Shamma, Shihab/F-9852-2012
OI Elhilali, Mounya/0000-0003-2597-738X;
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NR 117
TC 98
Z9 99
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 159
EP 176
DI 10.1016/j.heares.2005.01.015
PG 18
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100014
PM 16081006
ER
PT J
AU Syka, J
Suta, D
Popelar, J
AF Syka, J
Suta, D
Popelar, J
TI Responses to species-specific vocalizations in the auditory cortex of
awake and anesthetized guinea pigs
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE anesthesia; ketamine; vocalization; guinea pig; auditory cortex;
multiple-unit activity
ID SINGLE-UNIT ACTIVITY; INFERIOR COLLICULUS; COCHLEAR NUCLEUS; NEURONS;
ANESTHESIA; CAT; THALAMUS; KETAMINE; SLEEP; STATE
AB Species-specific vocalizations represent an important acoustical signal that must be decoded in the auditory system of the listener. We were interested in examining to what extent anesthesia may change the process of signal decoding in neurons of the auditory cortex in the guinea pig. With this aim, the multiple-unit activity, either spontaneous or acoustically evoked, was recorded in the auditory cortex of guinea pigs, at first in the awake state and then after the injection of anesthetics (33 mg/kg ketamine with 6.6 mg/kg xylazine). Acoustical stimuli, presented in free-field conditions, consisted of four typical guinea pig calls (purr, chatter, chirp and whistle), a time-reversed version of the whistle and a broad-band noise burst. The administration of anesthesia typically resulted in a decrease in the level of spontaneous activity and in changes in the strength of the neuronal response to acoustical stimuli. The effect of anesthesia was mostly, but not exclusively, suppressive. Diversity in the effects of anesthesia led in some recordings to an enhanced response to one call accompanied by a suppressed response to another call. The temporal pattern of the response to vocalizations was changed in some cases under anesthesia, which may indicate a change in the synaptic input of the recorded neurons. In summary, our results suggest that anesthesia must be considered as an important factor when investigating the processing of complex sounds such as species-specific vocalizations in the auditory cortex. (c) 2005 Elsevier B.V. All rights reserved.
C1 Acad Sci Czech Republ, Inst Expt Med, Prague 14220, Czech Republic.
Charles Univ, Fac Med 3, Prague, Czech Republic.
RP Syka, J (reprint author), Acad Sci Czech Republ, Inst Expt Med, Videnska 1083, Prague 14220, Czech Republic.
EM syka@biomed.cas.cz
RI Popelar, Jiri/H-2558-2014; Syka, Josef/H-3103-2014; Suta,
Daniel/H-2577-2014
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NR 29
TC 32
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 177
EP 184
DI 10.1016/j.heares.2005.01.013
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100015
PM 16081007
ER
PT J
AU Illing, RB
Kraus, KS
Meidinger, MA
AF Illing, RB
Kraus, KS
Meidinger, MA
TI Reconnecting neuronal networks in the auditory brainstem following
unilateral deafening
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE superior olivary complex; synaptic remodeling; cochlear lesion;
plasticity; adult CNS; regeneration
ID VENTRAL COCHLEAR NUCLEUS; EXPERIENCE-DEPENDENT PLASTICITY; MESSENGER-RNA
EXPRESSION; SUPERIOR OLIVARY COMPLEX; EAR OSSICLE REMOVAL; ADULT-RAT;
PROTEIN GAP-43; VISUAL-CORTEX; OLIVOCOCHLEAR NEURONS; SYNAPTIC
PLASTICITY
AB When we disturbed the auditory input of the adult rat by cochleotomy or noise trauma on one side, several substantial anatomical, cellular, and molecular changes took place in the auditory brainstem. We found that: (1) cochleotomy or severe noise trauma both lead to a considerable increase of immunoreactivity of the growth-associated protein GAP-43 in the ventral cochlear nucleus (VCN) of the affected side; (2) the expression of GAP-43 in VCN is restricted to presynaptic endings and short fiber segments; (3) axon collaterals of the cholinergic medial olivocochlear (MOC) neurons are the path along which GAP-43 reaches VCN; (4) partial cochlear lesions induce the emergence of GAP-43 positive presynaptic endings only in regions tonotopically corresponding to the extent of the lesion; (5) judging from the presence of immature fibers and growth cones in VCN on the deafened side, at least part of the GAP-43 positive presynaptic endings appear to be newly formed neuronal contacts following axonal sprouting while others may be modified pre-existing contacts; and (6) GAP-43 positive synapses are formed only on specific postsynaptic profiles, i.e., glutamatergic, glycinergic and calretinin containing cell bodies, but not GABAergic cell bodies. We conclude that unilateral deafening, be it partial or total, induces complex patterns of reconnecting neurons in the adult auditory brainstem, and we evaluate the possibility that the deafness-induced chain of events is optimized to remedy the loss of a bilaterally balanced activity in the auditory brainstem. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Freiburg, Dept Otorhinolaryngol, Neurobiol Res Lab, D-79106 Freiburg, Germany.
RP Illing, RB (reprint author), Univ Freiburg, Dept Otorhinolaryngol, Neurobiol Res Lab, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM robert.illing@uniklinik-freiburg.de
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NR 85
TC 30
Z9 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 185
EP 199
DI 10.1016/j.heares.2005.01.016
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100016
PM 16081008
ER
PT J
AU Kaltenbach, JA
Zhang, JS
Finlayson, P
AF Kaltenbach, JA
Zhang, JS
Finlayson, P
TI Tinnitus as a plastic phenomenon and its possible neural underpinnings
in the dorsal cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE tinnitus; plasticity; dorsal cochlear nucleus; tinnitus mechanisms;
neural correlates of tinnitus; tinnitus generation; tinnitus modulation;
deafferentation; mechanisms
ID GAZE-EVOKED TINNITUS; AUDITORY BRAIN-STEM; HAIR-CELL LOSS; PARALLEL
FIBER STIMULATION; LOCUS COERULEUS NEURONS; SHORT-TERM POTENTIATION;
CONDUCTIVE HEARING-LOSS; INTENSE SOUND EXPOSURE; EAR OSSICLE REMOVAL;
PROTEIN-KINASE-A
AB Tinnitus displays many features suggestive of plastic changes in the nervous system. These can be categorized based oil the types of manipulations that induce them. We have categorized the various forms of plasticity that characterize tinnitus and searched for their neural underpinnings in the dorsal cochlear nucleus (DCN). This structure has been implicated as a possible site for the generation of tinnitus-producing signals owing to its tendency to become hyperactive following exposure to tinnitus inducing agents such as intense sound and cisplatin. In this paper, we review the many forms of plasticity that have been uncovered in anatomical, physiological and neurochemical Studies of the DCN. Some of these plastic changes have been observed as consequences of peripheral injury or as fluctuations in the behavior and chemical activities of DCN neurons, while others can be induced by stimulation of auditory or even non-auditory structures. We show that many parallels can be drawn between the various forms of plasticity displayed by tinnitus and the various forms of neural plasticity which have been defined in the DCN. These parallels lend further support to the hypothesis that the DCN is an important site for the generation and modulation of tinnitus-producing signals. (c) 2005 Elsevier B.V. All rights reserved.
C1 Wayne State Univ, Sch Med, Dept Otolaryngol, Detroit, MI 48201 USA.
RP Kaltenbach, JA (reprint author), Wayne State Univ, Sch Med, Dept Otolaryngol, 5E-UHC, Detroit, MI 48201 USA.
EM jkalten@med.wayne.edu
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NR 195
TC 92
Z9 99
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 200
EP 226
DI 10.1016/j.heares.2005.02.013
PG 27
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100017
PM 16081009
ER
PT J
AU Brozoski, TJ
Bauer, CA
AF Brozoski, TJ
Bauer, CA
TI The effect of dorsal cochlear nucleus ablation on tinnitus in rats
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Symposium on Molecular Mechanisms in Central Auditory Function,
Plasticity and Disorder
CY JUN 25-27, 2004
CL Jackson Hole, WY
DE tinnitus; dorsal cochlear nucleus; ablation; animal model
ID CENTRAL NEUROPLASTICITY; PATHOLOGICAL PAIN; LIMBIC SYSTEM; PLASTICITY;
HEARING; MODEL; CAT
AB A growing body of evidence implies that the dorsal cochlear nucleus (DCN) plays an important role in tinnitus. To test the hypothesis that the rostral Output of the DCN is necessary for the experience of chronic tinnitus, the dorsal DCN and the dorsal acoustic stria of rats with psychophysical evidence of tinnitus was ablated. If the DCN plays a necessary role in the generation of chronic tinnitus, ablating the DCN should decrease the evidence of tinnitus in subjects previously shown to have tinnitus. Contrary to prediction, bilateral dorsal DCN ablation did not significantly (n = 11, p = 0.707) affect the psychophysical evidence of tinnitus, and ipsilateral dorsal DCN ablation appeared to increase the evidence of tinnitus (n = 9, p = 0.018) compared to pre-ablation performance. It was concluded that the DCN does not act as a simple feed-forward source of chronic tinnitus. Alternative hypotheses were considered, among them that elevated DCN activity following acoustic trauma triggers persistent pathological changes distributed across more than one level of the auditory system. In addition to serving as a trigger, the DCN may also modify the experience of tinnitus, since the evidence of tinnitus was enhanced by ipsilateral DCN ablation. (c) 2005 Elsevier B.V. All rights reserved.
C1 So Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Springfield, IL 62794 USA.
RP Brozoski, TJ (reprint author), So Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Springfield, IL 62794 USA.
EM tbrozoski@siLimed.edu
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NR 24
TC 51
Z9 54
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2005
VL 206
IS 1-2
SI SI
BP 227
EP 236
DI 10.1016/j.heares.2004.12.013
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 957EJ
UT WOS:000231352100018
PM 16081010
ER
PT J
AU Gomide, VC
de Francisco, AC
Chadi, G
AF Gomide, VC
de Francisco, AC
Chadi, G
TI Localization of neurotensin immunoreactivity in neurons and organ of
corti of rat cochlea
SO HEARING RESEARCH
LA English
DT Article
DE neurotensin; auditory; inner ear; neurotransmitter
ID FIBROBLAST-GROWTH-FACTOR; TOPOGRAPHICAL DISTRIBUTION; REACTIVE
ASTROCYTES; SUBSTANCE-P; GUINEA-PIG; RECEPTORS; BRAIN; PEPTIDES;
NUCLEUS; SYSTEM
AB The distribution of neurotensin-containing cell bodies and fibers has been observed in the central and peripheral nervous system, including sensory ganglia, but no description has been found in the peripheral auditory system. Here, we investigated the presence of neurotensin immunoreactivity in the cochlea of the adult Wistar rat. Strong neurotensin immunoreactivity was detected in the cytoplasm of the inner hair cells (IHC) and Deiters' cells of the organ of Corti. Outer hair cells (OHC) show weak immunoreaction. Neurotensin immunoreactivity was also found in the neurons and fibers of the spiral ganglia. Quantitative microdensitometric image analysis of the neurotensin immunoreactivity showed a strong immunoreaction in the hair cells of organ of Corti and a moderate to strong labeling in the spiral ganglion neurons. A series of double immunolabeling experiments demonstrated a strong neurotensin immunoreactivity in the parvalbumin immunoreactive IHC and also in the calbindin immunoreactive Deiters' cells. Weak neurotensin immunoreactivity was seen in the calbindin positive OHC. Neurofilament and parvalbumin immunoreactive neurons and fibers in the spiral ganglia showed neurotensin immunoreactivity. Calbindin immunoreactivity was not detected in the spiral ganglion neurons, which are labeled by neurotensin immunoreactivity. The presence of neurotensin in the cochlea may be related to its modulation of neurotransmission in the peripheral auditory pathway. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Neuroregenerat, BR-05508900 Sao Paulo, Brazil.
RP Chadi, G (reprint author), Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Neuroregenerat, Av Prof Lineu Prestes,2415, BR-05508900 Sao Paulo, Brazil.
EM gerchadi@usp.br
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NR 33
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 1
EP 6
DI 10.1016/j.heares.2005.02.011
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400001
PM 15953510
ER
PT J
AU Fay, RR
AF Fay, RR
TI Perception of pitch by goldfish
SO HEARING RESEARCH
LA English
DT Article
DE fish; harmonic complex; periodicity pitch; residue pitch
ID AUDITORY STREAM SEGREGATION; CARASSIUS-AURATUS; ACOUSTIC RESPONSE;
NERVE-FIBERS; SOUND; HEARING; SIGNALS; MODELS; NOISE; FISH
AB Classical conditioning and stimulus generalization methods have revealed much about the sense of hearing in non-human animals, and are now used here to investigate how goldfish perceive a variety of complex sounds, including multi-harmonic complexes and rippled noise (RN). In several experiments, animals were conditioned to respond to one type of complex sound, and were then tested for generalization to other sounds differing along one or more acoustic dimensions from the conditioning sounds. Overall, generalization occurred only to the extent that the conditioning and test sounds were essentially similar in spectral range and, in most cases, waveform periodicity. For example, goldfish showed inverted V-shaped generalization gradients to harmonic complexes varying in fundamental frequency after conditioning to complexes having a fundamental frequency of 100 Hz. In several cases, similar gradients were observed whether the fundamental frequency component was present or absent in conditioning and testing complexes, indicating that goldfish, like other vertebrate listeners, do not "miss the fundamental" when it is missing. This generalization pattern tended to disappear when harmonic complexes were used that had random phase relations among the components, or slight mistuning of all components. In a few cases, patterns of generalization were determined by as yet unidentified acoustic features. Goldfish did not generalize to RN or harmonic complexes after conditioning to tones, and vice versa, in spite of the three signal types having fundamental frequency components and periodicity in common. Moreover, goldfish did not generalize robustly to infinitely iterated rippled noise after conditioning to harmonic complexes with a prominent periodic envelope, and vice versa, in spite of the two signal types having similar spectra and pitches as judged by human listeners. These and other results suggest that the pitch of harmonic complexes is prominent in goldfish generalization behavior and that this pitch-like dimension arises primarily from the signal's periodicity. The perceptions of single tones, RNs, and harmonic complexes having the sane fundamental frequency are fundamentally different. It is concluded that the different perceptions of these signals arise in part from differences in periodic envelope prominence and spectral envelope, and possibly in the stochastic versus deterministic natures of their respective waveforms. (c) 2005 Elsevier B.V. All rights reserved.
C1 Loyola Univ, Parmly Hearing Inst, Chicago, IL 60626 USA.
Loyola Univ, Dept Psychol, Chicago, IL 60626 USA.
RP Fay, RR (reprint author), Loyola Univ, Parmly Hearing Inst, 6525 N Sheridan Rd, Chicago, IL 60626 USA.
EM rfay@luc.edu
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NR 35
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 7
EP 20
DI 10.1016/j.heares.2005.02.006
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400002
PM 15953511
ER
PT J
AU Stevens, HE
Wickesberg, RE
AF Stevens, HE
Wickesberg, RE
TI Auditory nerve representation of naturally-produced vowels with variable
acoustics
SO HEARING RESEARCH
LA English
DT Article
ID TEMPORAL DISCHARGE PATTERNS; STEADY-STATE VOWELS; PIG COCHLEAR-NERVE;
STOP CONSONANTS; COMPLEX TONES; FIBERS; RESPONSES; SPEECH; SOUNDS;
SYLLABLES
AB This investigation compared the encoding of naturally-produced, whispered and normally-voiced vowels by auditory nerve fibers. Speech syllables containing the vowels /o/ and /ae/ were produced by two female speakers and presented at three intensities to ketamine-anesthetized chinchillas. Six different representations of the spectral components in the vowels in the responses of the auditory nerve fibers were evaluated. For both normal and whispered vowels over a 30 dB range, the formant peaks in the vowel were best displayed using rate-place representations. The spectral detail in the vowel was revealed by average localized synchronized rates (ALSR) and autocorrelations of individual peristimulus time histograms. The average localized interval rates (ALIR), autocorrelations of ensemble responses, and autocorrelations of individual spike trains demonstrated poor representations of vowel spectra, although the frequency components of normally-voiced vowels had better representations than those of whispered vowels. These analyses suggest that rate-based and synchronization-based measures yields two very different pieces of information, but only a normalized rate-based measure consistently identified the formants of both the whispered and normally-voiced vowels. (c) 2005 Published by Elsevier B.V.
C1 Univ Illinois, Dept Psychol, Champaign, IL 61820 USA.
Univ Illinois, Neurosci Program, Urbana, IL 61801 USA.
RP Wickesberg, RE (reprint author), Univ Illinois, Dept Psychol, Champaign, IL 61820 USA.
EM hesteven@uiuc.edu; wickesbe@uiuc.edu
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NR 27
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 21
EP 34
DI 10.1016/j.heares.2005.02.008
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400003
PM 15953512
ER
PT J
AU Bobbin, RP
Salt, AN
AF Bobbin, RP
Salt, AN
TI ATP-gamma-S shifts the operating point of outer hair cell transduction
towards scala tympani
SO HEARING RESEARCH
LA English
DT Article
DE ATP receptor; ATP-gamma-S; operating point; cochlear microphonic;
basilar membrane mechanics
ID GUINEA-PIG COCHLEA; LOW-FREQUENCY TONES; MECHANOELECTRICAL TRANSDUCTION;
PHARMACOLOGICAL EVIDENCE; PURINERGIC RECEPTORS; SUPPORTING CELLS;
ADAPTATION; MOVEMENT; CALCIUM; SENSITIVITY
AB ATP receptor agonists and antagonists alter cochlear mechanics as measured by changes in distortion product otoacoustic emissions (DPOAE). Some of the effects on DPOAEs are consistent with the hypothesis that ATP affects mechano-electrical transduction and the operating point of the outer hair cells (OHCs). This hypothesis was tested by monitoring the effect of ATP-gamma-S on the operating point of the OHCs. Guinea pigs anesthetized with urethane and with sectioned middle ear muscles were used. The cochlear microphonic (CM) was recorded differentially (scala vestibuli referenced to scala tympani) across the basal turn before and after perfusion (20 min) of the perilymph compartment with artificial perilymph (AP) and ATP-gamma-S dissolved in AP. The operating point was derived from the cochlear microphonics (CM) recorded in response low frequency (200 Hz) tones at high level (106, 112 and 118 dB SPL). The analysis procedure used a Boltzmann function to simulate the CM waveform and the Boltzmann parameters were adjusted to best-fit the calculated waveform to the CM. Compared to the initial perfusion with AP, ATP-gamma-S (333 mu M) enhanced peak clipping of the positive peak of the CM (that occurs during organ of Corti displacements towards scala tympani), which was in keeping with ATP-induced displacement of the transducer towards scala tympani. CM waveform analysis quantified the degree of displacement and showed that the changes were consistent with the stimulus being centered on a different region of the transducer curve. The change of operating point meant that the stimulus was applied to a region of the transducer curve where there was greater saturation of the output on excursions towards scala tympani and less saturation towards scala vestibuli. A significant degree of recovery of the operating point was observed after washing with AP. Dose response curves generated by perfusing ATP-gamma-S (333 mu M) in a cumulative manner yielded an EC50 of 19.8 mu M. The ATP antagonist PPADS (0.1 mM) failed to block the effect of ATP-gamma-S on operating point, suggesting the response was due to activation of metabotropic and not ionotropic ATP receptors. Multiple perfusions of AP had no significant effect (118 and 112 dB) or moved the operating point slightly (106 dB) in the direction opposite of ATP-gamma-S. Results are consistent with an ATP-gamma-S induced transducer change comparable to a static movement of the organ of Corti or reticular lamina towards scala tympani. (c) 2005 Elsevier B.V. All rights reserved.
C1 Louisiana State Univ, Sch Med, Dept Otolaryngol, Kresge Hearing Res Inst, New Orleans, LA 70112 USA.
Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Bobbin, RP (reprint author), Louisiana State Univ, Sch Med, Dept Otolaryngol, Kresge Hearing Res Inst, 533 Bolivar St,5th Floor, New Orleans, LA 70112 USA.
EM rbobbi@lsuhsc.edu
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NR 36
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 35
EP 43
DI 10.1016/j.heares.2005.02.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400004
PM 15953513
ER
PT J
AU Parazzini, M
Hall, AJ
Lutman, ME
Kapadia, S
AF Parazzini, M
Hall, AJ
Lutman, ME
Kapadia, S
TI Effect of aspirin on phase gradient of 2F1-F2 distortion product
otoacoustic emissions
SO HEARING RESEARCH
LA English
DT Article
DE distortion product otoacoustic emissions; aspirin; phase gradient
ID ACOUSTIC EMISSIONS; GUINEA-PIG; HUMAN EAR; SALICYLATE; MECHANISMS;
DPOAE; MICROSTRUCTURE
AB It is well known that aspirin consumption temporarily reduces overall otoacoustic emission (OAE) amplitude in humans. However, little is known about changes in the separate components of distortion product otoacoustic emissions (DPOAE), which may be distinguished by examining phase gradients. The effects of aspirin on the phase gradient of the DPOAE 2F1-F2 obtained with fixed frequency ratio sweeps were studied longitudinally in a group of twelve subjects in whom a temporary hearing loss was induced by aspirin consumption. DPOAE were recorded daily for two days pre-aspirin consumption, during the three days of aspirin consumption and two days afterwards. DP-grams were recorded over a restricted frequency range centered on 2, 3, 4 and 6 kHz with the following stimulus levels: L1/L2 of 60/50-80/70 in 10-dB steps. The effects of aspirin on the phase gradients varied between the subjects and across frequency: the general trend was that the phase gradient became steeper across successive sessions for the higher frequencies, while no significant effect was found at the lower frequencies. These results suggest that aspirin may have more persistent effects on cochlear function than are disclosed by measurements of hearing threshold level or DPOAE amplitude. Particularly, DPOAE phase gradient appears to be increased by aspirin consumption and has not recovered two days after cessation of aspirin intake, despite almost complete recovery of DPOAE amplitude and hearing threshold levels. These findings may suggest differential effects on the distortion and reflection mechanisms considered to underlie DPOAE generation. (c) 2005 Elsevier B.V. All rights reserved.
C1 CNR, Ist Ingn Biomed ISIB, I-20133 Milan, Italy.
Univ Southampton, Inst Sound & Vibrat Res, Southampton SO9 5NH, Hants, England.
RP Parazzini, M (reprint author), CNR, Ist Ingn Biomed ISIB, Piazza Leonardo Vinci 32, I-20133 Milan, Italy.
EM marta.parazzini@polimi.it
RI Parazzini, Marta/J-8175-2014
OI Parazzini, Marta/0000-0001-9008-7530
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NR 27
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 44
EP 52
DI 10.1016/j.heares.2005.02.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400005
PM 15953514
ER
PT J
AU Junius, D
Dau, T
AF Junius, D
Dau, T
TI Influence of cochlear traveling wave and neural adaptation on auditory
brainstem responses
SO HEARING RESEARCH
LA English
DT Article
DE auditory brainstem response; frequency following response; cochlear
traveling wave; stimulus rate; neural adaptation
ID SHORT-TERM ADAPTATION; HIGH CLICK RATE; RISE-FALL TIME; EVOKED-RESPONSE;
NERVE FIBERS; INTERSTIMULUS-INTERVAL; FREQUENCY SPECIFICITY; MASKING
FUNCTIONS; HEARING-LOSS; TONE-BURSTS
AB The present study investigates the relationship between evoked responses to transient broadband chirps and responses to the same chirps when embedded in longer-duration stimuli. It examines to what extent the responses to the composite stimuli can be explained by a linear superposition of the responses to the single components, as a function of stimulus level. In the first experiment, a single rising chirp was temporally and spectrally embedded in two steady-state tones. In the second experiment, the stimulus consisted of a continuous alternating train of chirps: each rising chirp was followed by the temporally reversed (falling) chirp. In both experiments, the transitions between stimulus components were continuous. For stimulation levels up to approximately 70 dB SPL, the responses to the embedded chirp corresponded to the responses to the single chirp. At high stimulus levels (80-100 dB SPL), disparities occurred between the responses, reflecting a nonlinearity in the processing when neural activity is integrated across frequency. In the third experiment, the effect of within-train rate on wave-V response was investigated. The response to the chirp presented at a within-train rate of 95 Hz exhibited the same amplitude as that to the chirp presented in the traditional single-stimulus;paradigm at a rate of 13 Hz. For a corresponding experiment with bandlimited chirps of 4 ms duration, where the within-train rate was 250 Hz, a clear reduction of the response amplitude was observed. This nonlinearity in terms of temporal processing most likely reflects effects of short-term adaptation. Overall, the results of the present study further demonstrate the importance of cochlear processing for the formation of brainstem potentials. The data may provide constraints on future models of peripheral processing in the human auditory system. The findings might also be useful for the development of effective stimulation paradigms in clinical applications. (c) 2005 Elsevier B.V. All rights reserved.
C1 Carl Ossietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
Tech Univ Denmark, Ctr Appl Hearing Res, DK-2800 Lyngby, Denmark.
RP Dau, T (reprint author), Carl Ossietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
EM tda@oersted.dtu.dk
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NR 41
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 53
EP 67
DI 10.1016/j.heares.2005.03.001
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400006
PM 15953515
ER
PT J
AU de Groot, JCMJ
Hendriksen, EGJ
Smoorenburg, GF
AF de Groot, JCMJ
Hendriksen, EGJ
Smoorenburg, GF
TI Reduced expression of sialoglycoconjugates in the outer hair cell
glycocalyx after systemic aminoglycoside administration
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; outer hair cells; glycocalyx sialoglycoconjugates;
aminoglycoside ototoxicity; gentamicin; neomycin
ID PIG INNER-EAR; ENDOPLASMIC-RETICULUM STRESS; WHEAT-GERM-AGGLUTININ;
GUINEA-PIG; IN-VITRO; GENTAMICIN OTOTOXICITY; COCHLEAR CULTURES;
HYDROPIC COCHLEAS; DRUG OTOTOXICITY; LECTIN-BINDING
AB In this study we investigated the effect of systemic aminoglycoside administration on the expression of sialoglycoconjugates in the outer hair cell (OHC) glycocalyx of the adult guinea pig. Sialoglycoconjugates were visualized by means of ultrastructural lectin cytochemistry, using Lunax flavus agglutinin (LFA) and wheat germ agglutinin (WGA) as probes. Labelling densities were determined for the apical membranes (including the stereocilia and stereociliary cross-links) and basolateral membranes of OHCs in the respective (basal, middle and apical) cochlear turns from animals that had been treated with gentamicin or neomycin for 5 or 15 consecutive days. Our results indicate that: (1) sialoglycoconjugate expression in the OHC glycocalyx demonstrates an intracochlear gradient decreasing towards the apical turn; (2) OHCs demonstrate a polarity in sialoglycoconjugate expression, in that the basolateral membranes contain more sialoglycoconjugates per surface area than the apical membranes; (3) aminoglycoside administration results in reduced expression of sialoglycoconjugates in the OHC glycocalyx; in this respect, basal-turn OHCs are more susceptible than those in the middle and apical turns; (4) reduction in sialoglycoconjugate expression after aminoglycoside administration is more prominent in the basolateral membranes; and (5) the difference in ototoxic potencies between gentamicin and neomycin is not reflected at the level of sialoglycoconjugate expression. The present data support our earlier hypothesis that aminoglycosides, already at an early phase of intoxication, interfere with the function of the endoplasmic reticulum and/or the Golgi apparatus, implying that these organelles play a crucial role in the initial phase of aminoglycoside-induced OHC degeneration. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Utrecht, Ctr Med, Dept Otorhinolaryngol, Hearing Res Labs, NL-3508 GA Utrecht, Netherlands.
RP de Groot, JCMJ (reprint author), Univ Utrecht, Ctr Med, Dept Otorhinolaryngol, Hearing Res Labs, Room G-02-531,POB 85-500, NL-3508 GA Utrecht, Netherlands.
EM J.C.M.J.deGroot@kmb.azu.nl
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NR 63
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 68
EP 82
DI 10.1016/j.heares.2005.03.002
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400007
PM 15953516
ER
PT J
AU Khan, AM
Whiten, DM
Nadol, JB
Eddington, DK
AF Khan, AM
Whiten, DM
Nadol, JB
Eddington, DK
TI Histopathology of human cochlear implants: Correlation of psychophysical
and anatomical measures
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implantation; spiral ganglion cells; psychophysics
ID SENSORINEURAL HEARING-LOSS; SPIRAL GANGLION-CELLS; SPEECH-RECOGNITION;
ELECTRODE DISCRIMINATION; TEMPORAL BONES; COST-UTILITY; PLACE-PITCH;
PERCEPTION; PATIENT; RECONSTRUCTION
AB The cadavaric temporal bones of five subjects who underwent cochlear implantation during life (2 Nucleus and 3 Ineraid) were analyzed using two-dimensional (2D) reconstruction of serial sections to determine the number of surviving spiral ganglion cells (SGCs) in the region of each electrode of the implanted arrays. The last psychophysical threshold and maximum-comfortable sensation level treasured for each electrode were compared to their respective SGC count to determine the across-electrode psychophysical variance accounted for by the SGC counts. Significant correlations between psychophysical measures and SGC counts were found in only two of the five subjects: one Nucleus implantee (e.g., r=-0.71; p < 0.001 for threshold vs. count) and one Ineraid implantee (e.g., r=-0.86; p < 0.05 for threshold vs. count). A three-dimensional (3D) model of the implanted cochlea was formulated using the temporal-bone anatomy of the Nucleus subject for whom the 2D analysis did not result in significant correlations between counts and psychophysical measures. Predictions of the threshold vs. electrode profile were closer to the measured profile for the 3D model than for the 2D analysis. These results lead us to hypothesize that 3D techniques will be required to asses the impact of peripheral anatomy on the benefit patients derive from cochlear implantation. (c) 2005 Elsevier B.V. All rights reserved.
C1 Massachusetts Eye & Ear Infirm, Cochlear Implant Res Lab, Boston, MA 02114 USA.
Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02114 USA.
MIT, Div Hlth Sci & Technol, Speech & Hearing Biosci & Technol Program, Cambridge, MA 02369 USA.
MIT, Elect Res Lab, Cambridge, MA 02369 USA.
RP Eddington, DK (reprint author), Massachusetts Eye & Ear Infirm, Cochlear Implant Res Lab, 243 Charles St, Boston, MA 02114 USA.
EM dke@cirl.meei.harvard.edu
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NR 50
TC 25
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 83
EP 93
DI 10.1016/j.heares.2005.03.003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400008
PM 15953517
ER
PT J
AU Mortensen, MV
Madsen, S
Gjedde, A
AF Mortensen, MV
Madsen, S
Gjedde, A
TI Use of time differences in normal hearing - cortical processing of
promontorial stimuli
SO HEARING RESEARCH
LA English
DT Article
DE PET; duration discrimination; promontory; stimulation; temporal
analysis; speech perception; somatosensory cortex
ID POSITRON EMISSION TOMOGRAPHY; AUDITORY BRAIN-STEM;
ELECTRICAL-STIMULATION; DURATION DISCRIMINATION; SPEECH RECOGNITION;
COCHLEAR IMPLANTS; FRONTAL-CORTEX; ROUND WINDOW; ACTIVATION; MEMORY
AB To test the hypothesis that ability to discriminate small duration differences is positively correlated with activity in the right temporal lobe, we used positron emission tomography in six normally hearing subjects, stimulated via the promontory in a procedure that mimics the auditory nerve stimulation with a cochlear implant. Stimulus consisted of electrical bursts, and tasks included gap detection and temporal difference limen (TDL). TDL is a measure of discriminatory processing of sound duration in cochlear implant candidates, demonstrated to predict outcome. Good speech perception after cochlear implantation is associated with activity in right temporal areas.
Although perceived variably by the subjects, the stimulus itself activated bilateral secondary somatosensory cortex, suggesting differential stimulation of multiple sensory modalities. Only TDL raised blood flow in both posterior middle temporal gyri (MTG) and the right prefrontal cortex. As the right posterior MTG is known to be active during duration discrimination of different modalities and in the perception of words containing manipulated phonemes, we conclude that recruitment of this part of the right hemisphere is important to the comprehension of speech containing mostly temporal cues. The study shows that stimulus-induced activation reflects the goal of the task rather than the nature of the stimulus. (c) 2005 Elsevier B.V. All rights reserved.
C1 Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus, Denmark.
Aarhus Univ Hosp, Dept ENT, DK-8000 Aarhus, Denmark.
Aarhus Univ, Ctr Funct Integrat Neurosci, Aarhus, Denmark.
RP Mortensen, MV (reprint author), Aarhus Univ Hosp, PET Ctr, 44 Norrebrogade, DK-8000 Aarhus, Denmark.
EM malene@pet.auh.dk
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NR 73
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 94
EP 101
DI 10.1016/j.heares.2005.03.007
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400009
PM 15953518
ER
PT J
AU Cheng, PW
Liu, SH
Hsu, CJ
Lin-Shiau, SY
AF Cheng, PW
Liu, SH
Hsu, CJ
Lin-Shiau, SY
TI Correlation of increased activities of Na+, K+-ATPase and Ca2+-ATPase
with the reversal of cisplatin ototoxicity induced by D-methionine in
guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE auditory brainstem response; Ca2+-ATPase; cisplatin; D-methionine; Na+;
K+-ATPase; ototoxicity
ID TEMPORAL BONE HISTOPATHOLOGY; INNER-EAR; LATERAL WALL; ANTIOXIDANT
SYSTEM; STRIA VASCULARIS; COCHLEAR DUCT; MARGINAL CELLS; CIS-PLATINUM;
CA++-ATPASE; LOCALIZATION
AB Na+, K+-ATPase and Ca2+-ATPase in the cochlear lateral wall play an important role in maintaining ionic homeostasis and physiologic function of the cochlea. The present study was designed to test whether the changes of Na+, K+-ATPase and Ca2+-ATPase activities of the cochlear lateral wall and the brainstem of guinea pigs after receiving cisplatin for seven consecutive days were correlated with the altered auditory brainstem responses (ABR). Furthermore, whether a chemoprotective agent, D-methionine reversed the increased ABR threshold induced by cisplatin accompanied with the increased ATPase activities was also evaluated. The results obtained showed that cisplatin exposure caused not only a significant increase of threshold but also altered various absolute wave and interwave latencies of ABR. In addition, cisplatin significantly decreased the Na+, K+-ATPase and Ca2+-ATPase activities in the cochlear lateral wall with a good dose-response relationship. Regression analysis indicated that an increase of ABR threshold was well correlated with a decrease of both Na+, K+-ATPase and Ca2+-ATPase activities in the cochlear lateral wall. A chemoprotectant, D-methionine indeed reversed both abnormalities of ABR and ATPase activities in a well correlation function. The selectivity of these observed changes induced by cisplatin and D-methionine was revealed by the findings that cisplatin-treated guinea pigs had normal III-V interwave latency of ABR and no reduction of Na+, K+-ATPase and Ca2+-ATPase specific activities in the brainstem, which is in accordance with the nonpenetrable cisplatin across the blood brain barrier. Taken all together, the present findings suggest that biochemical damage and ionic disturbance may contribute to cisplatin-induced ototoxicity to some extent, which can be reversed by D-methionine. (c) 2005 Elsevier B.V. All rights reserved.
C1 Natl Taiwan Univ, Coll Med, Inst Toxicol, Taipei 10764, Taiwan.
Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei 10764, Taiwan.
Far Eastern Mem Hosp, Dept Otolaryngol, Taipei, Taiwan.
Natl Taiwan Univ, Coll Med, Dept Otolaryngol, Taipei 10764, Taiwan.
RP Lin-Shiau, SY (reprint author), Natl Taiwan Univ, Coll Med, Inst Toxicol, Taipei 10764, Taiwan.
EM syl@ha.mc.ntu.edu.tw
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NR 39
TC 28
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 102
EP 109
DI 10.1016/j.heares.2005.03.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400010
PM 15953519
ER
PT J
AU Bobbin, RP
Bledsoe, SC
AF Bobbin, RP
Bledsoe, SC
TI Asphyxia and depolarization increase adenosine levels in perilymph
SO HEARING RESEARCH
LA English
DT Article
DE ATP; cochlea; neurotransmitter; release
ID GUINEA-PIG COCHLEA; CENTRAL-NERVOUS-SYSTEM; ELECTRICAL-STIMULATION;
HIPPOCAMPAL SLICES; CHINCHILLA COCHLEA; SKELETAL-MUSCLE; INDUCED
RELEASE; VAS-DEFERENS; RAT COCHLEA; RECEPTOR
AB Extracellular adenosine has been suggested as a modulator of cochlear function. To date the release of adenosine into the extracellular spaces of the cochlea has not been demonstrated. Therefore, experiments were designed to examine whether adenosine release into perilymph could be detected in response to depolarization by high potassium concentrations or in response to asphyxia. For this purpose, the perilymph compartment of guinea pigs was perfused with an artificial perilymph and the effluent assayed for ATP, ADP, AMP and adenosine. Results indicate that potassium induced a slight, significant increase and asphyxia induced a very large, significant increase in adenosine levels in perilymph effluent. No changes in the levels of the other compounds were measured. It is concluded that depolarization and asphyxia can induce the release of adenosine into perilymph. (c) 2005 Elsevier B.V. All rights reserved.
C1 Louisiana State Univ, Hlth Sci Ctr, Sch Med, Kresge Hearing Res Lab,Dept Otolaryngol, New Orleans, LA 70112 USA.
Univ Michigan, Sch Med, Dept Otolaryngol, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
RP Bobbin, RP (reprint author), Louisiana State Univ, Hlth Sci Ctr, Sch Med, Kresge Hearing Res Lab,Dept Otolaryngol, 533 Bolivar St,5th Floor, New Orleans, LA 70112 USA.
EM rbobbi@lsuhsc.edu
CR BOBBIN RP, 1990, HEARING RES, V46, P83, DOI 10.1016/0378-5955(90)90141-B
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NR 34
TC 3
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 110
EP 114
DI 10.1016/j.heares.2005.03.009
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400011
PM 15953520
ER
PT J
AU Lu, W
Xu, J
Shepherd, RK
AF Lu, W
Xu, J
Shepherd, RK
TI Cochlear implantation in rats: A new surgical approach
SO HEARING RESEARCH
LA English
DT Article
DE cochlear histopathology; cochlear implant; electrically evoked auditory
brainstem response; stapedial artery
ID CHRONIC ELECTRICAL-STIMULATION; PERSISTENT STAPEDIAL ARTERY;
SENSORINEURAL HEARING-LOSS; TYMPANI ELECTRODE ARRAY; AUDITORY
BRAIN-STEM; MIDDLE-EAR; INFERIOR COLLICULUS; ANIMAL-MODEL; GUINEA-PIG;
NERVE
AB The laboratory rat has been used extensively in auditory research but has had limited use in cochlear implant related research due mainly to the surgically restricted access to the scala tympani. We have developed a new surgical method for cochlear implantation in rats. The key to this protocol was cauterizing the stapedial artery (SA) and making a small cochleostomy near the round window in order to enlarge the surgical access to the scala tympani. Five normal hearing Hooded Wistar rats were used to investigate the effect of cauterizing the SA on hearing and auditory nerve survival. Results showed that cauterizing the SA was surgically feasible, afforded excellent exposure of the round window niche for cochleostomy, and did not adversely affect acoustic thresholds measured electrophysiologically. Moreover, there was no difference in spiral ganglion cell densities for any cochlear turn when compared with the contralateral control ears. Three deafened rats were subsequently implanted with a scala tympani electrode array using this new surgical approach. Electrically evoked auditory brainstem responses using bipolar stimulation, and subsequent cochlear histopathology demonstrated that cochlear implantation using a custom-made rat electrode array was safe and effective. The surgical approach presented in this paper presents a safe and effective procedure for acute or chronic cochlear implantation in the rat model. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
Bion Ear Inst, Melbourne, Vic 3002, Australia.
Zhengzhou Univ, Dept Otolaryngol, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China.
RP Shepherd, RK (reprint author), Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Otolaryngol, 32 Gisborne St, Melbourne, Vic 3002, Australia.
EM rshepherd@bionicear.org
RI Shepherd, Robert/I-6276-2012
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NR 38
TC 13
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 115
EP 122
DI 10.1016/j.heares.2005.03.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400012
PM 15953521
ER
PT J
AU Barrenas, ML
Bratthall, A
Dahlgren, J
AF Barrenas, ML
Bratthall, A
Dahlgren, J
TI The association between short stature and sensorineural hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE hearing; stature; hypertension; phenotype; genotype; thrifty
ID GROWTH-FACTOR-I; THRIFTY PHENOTYPE HYPOTHESIS; PERSONAL CASSETTE
PLAYERS; RISK-FACTORS; BLOOD-PRESSURE; PRESCHOOL-CHILDREN; PRENATAL
EXPOSURE; ABDOMINAL OBESITY; NOISE EXPOSURE; BIRTH-WEIGHT
AB In order to test the Thrifty Phenotype Hypothesis on hearing, data from two cross-sectional studies on hearing were re-evaluated. The data sets comprised 500 18-year-old conscripts, and 483 noise-exposed male employees. Sensorineural hearing loss (SNHL) was over-represented among conscripts with a short stature (odds ratio = 2.2) or hearing loss in the family (odds ration = 4.2), but not among noise-exposed conscripts (odds ratio = 0.9-1.3). Among noise-exposed short employees, hypertension and age exhibited a negative impact on high frequency hearing thresholds, while among tall employees hypertension had no effect on hearing and the influence of age was less pronounced (p < 0.01 for body height; p < 0.02 for age, hypertension and the interaction between body height and hypertension; p < 0.05 for the interaction between body height and age). This suggests that mechanisms linked to fetal programming and growth retardation and/or insulin-like growth factor 1 levels during fetal life, such as a delayed cell cycle during the time window when the cochlea develops, may cause SNHL in adulthood. (c) 2005 Elsevier B.V. All rights reserved.
C1 Gothenburg Univ, Inst Hlth Women & Children, Dept Pediat, GP GRC, S-41685 Gothenburg, Sweden.
RP Barrenas, ML (reprint author), Gothenburg Univ, Inst Hlth Women & Children, Dept Pediat, GP GRC, S-41685 Gothenburg, Sweden.
EM marie-louise.barrenas@vgregion.se
CR Aitkin M., 1990, STAT MODELLING GLIM
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NR 63
TC 12
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 123
EP 130
DI 10.1016/j.heares.2005.03.019
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400013
PM 15953522
ER
PT J
AU Philibert, B
Collet, L
Vesson, JF
Veuillet, E
AF Philibert, B
Collet, L
Vesson, JF
Veuillet, E
TI The auditory acclimatization effect in sensorineural hearing-impaired
listeners: Evidence for functional plasticity
SO HEARING RESEARCH
LA English
DT Article
DE auditory acclimatization; hearing aid; asymmetry; auditory brainstem
response; rehabilitation
ID FREQUENCY DISCRIMINATION; INTENSITY DISCRIMINATION; CORTICAL
REORGANIZATION; LOUDNESS PERCEPTION; PRESENTATION LEVEL; COCHLEAR
DAMAGE; ORGAN DAMAGE; AID USE; CORTEX; BRAIN
AB The present study provides new data on perceptual and physiological modifications associated with hearing aid (HA) fitting. Eight sensorineural hearing-impaired (SNHI) listeners participated. They had symmetrical hearing loss and were being fitted with binaural HAs for the first time. Perceptual performances were measured four times during auditory rehabilitation, using an intensity discrimination task and a loudness-scaling task. Pure tones of two different frequencies were used, one well amplified by HAs and the other weakly amplified. Two intensity levels were also tested, one rated 'soft' by SNHI listeners and the other 'loud'. Auditory brainstem responses (ABRs) to click stimulation were recorded. All measures were performed without HA. Results were consistent with the auditory acclimatization effect: most modifications induced by HA fitting were found at loud intensity levels and at high frequency, i.e., for acoustic information that was newly available to the listener. While both ears had similar hearing loss and aided gains, some differences between ears appeared in both perceptual tasks and in ABRs. In the right ear, a shortening of wave V latency paralleled perceptual modifications. The present results suggest that HA-fitting induces functional plasticity at the peripheral level of the auditory system. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Lyon 1, Hospices Civils Lyon, CNRS, GDR 2213,UMR 5020,Lab Neurosci & Syst Sensoriels, F-69366 Lyon, France.
RP Philibert, B (reprint author), Univ Paris 11, Lab Neurobiol Apprentissage Mem & Commun, CNRS, UMR 8620, Batiment 446, F-91405 Orsay, France.
EM benedicte.philibert@ibaic.u-psud.fr
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NR 59
TC 25
Z9 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 131
EP 142
DI 10.1016/j.heares.2005.03.013
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400014
PM 15953523
ER
PT J
AU Briaire, JJ
Frijns, JHM
AF Briaire, JJ
Frijns, JHM
TI Unraveling the electrically evoked compound action potential
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; electrical volume conduction; auditory nerve; CAP
ID MYELINATED NERVE-FIBERS; ROTATIONALLY SYMMETRICAL MODEL; HUMAN COCHLEAR
NEURON; STIMULATED COCHLEA; SPEECH-PERCEPTION; VOLUME CONDUCTION;
PROSTHESIS DESIGN; IMPLANT; RESPONSES; ELECTROCOCHLEOGRAPHY
AB With the advent of eCAP recording tools such as NRT and NRI for cochlear implants, neural monitoring has become widely used to ascertain the integrity of the neural/electrode interface as well as for assisting in the setting of program levels. The basic concepts of eCAP recordings are deduced from the acoustical equivalent of the electrocochleogram. There are, however, indications that under electrical stimulation some of these do not hold, like the unitary response concept (i.e., the principle that every fiber produces the same contribution to the eCAP). Computer modeling has proven to be a valuable tool for gaining insight into the functioning of electrical stimulation. In this study the extension of a three-dimensional human cochlea, incorporating back-measuring capabilities, is described. Using this new model, the contribution of single fiber action potentials (SFAPs) to the measured eCAP is investigated. The model predicts that contrary to common belief - the compound action potential as measured by the cochlear implant system does not necessarily reflect the propagated action potential along the auditory nerve. (c) 2005 Elsevier B.V. All rights reserved.
C1 Leiden Univ, Ctr Med, ENT Dept, NL-2300 RC Leiden, Netherlands.
RP Briaire, JJ (reprint author), Leiden Univ, Ctr Med, ENT Dept, POB 9600, NL-2300 RC Leiden, Netherlands.
EM J.J.Briaire@LUMC.nl
RI Briaire, Jeroen/A-7972-2008; Frijns, Johan/H-6249-2011
OI Briaire, Jeroen/0000-0003-4302-817X;
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NR 36
TC 34
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 143
EP 156
DI 10.1016/j.heares.2005.03.020
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400015
PM 15953524
ER
PT J
AU Damaschke, J
Riedel, H
Kollmeier, B
AF Damaschke, J
Riedel, H
Kollmeier, B
TI Neural correlates of the precedence effect in auditory evoked potentials
SO HEARING RESEARCH
LA English
DT Article
DE precedence effect; auditory evoked potential; discrimination; mismatch
negativity
ID HUMAN BRAIN-STEM; INFERIOR COLLICULUS; SIMULATED ECHOES; MAXIMUM LENGTH;
CLICK-PAIRS; RESPONSES; LOCALIZATION; SUPPRESSION; CAT; INHIBITION
AB The precedence effect in subjective localization tasks reflects the dominance of directional information of a direct sound (lead) over the information provided by one or several reflections (lags) for short delays. By collecting data of both psych oacoustical measurements and auditory evoked potentials the current study aims at neurophysiological correlates for the precedence effect in humans. In order to investigate whether the stimulus features or the perception of the stimulus is reflected on the ascending stages of the human auditory pathway, auditory brainstem responses (ABRs) as well as cortical auditory evoked potentials (CAEPs) using double click-pairs were recorded. Potentials were related to the results of the psychoacoustical data.
ABRs to double click-pairs with lead-lag delays from 0 to 20 ms and interaural time differences (ITDs) in the lag click of 0 and 300 mu s show an emerging second wave V for lead-lag delays larger than 2 ms. The amplitudes of the first and second wave V are the same for a lead-lag delay of about 5 ms. For the lag-ITD stimuli the latency of the second wave V was prolonged by approximately ITD/2 compared to the stimuli without lag-ITD. As the amplitudes of the second wave V were not decreased for a lead-lag delay around 5 ms as could be expected from psychoacoustical measurements of the precedence effect, ABRs reflect stimulus features rather than the perceptive qualities of the stimulus.
The mismatch negativity (MMN) component of the CAEP for double click-pairs was determined using a diotic standard and a deviant with an ITD of 800 mu s in the lag click. The comparison between the MMN components and the psychoacoustical data shows that the MMN is related to the perception of the stimulus, i.e., to the precedence effect.
Generally, the findings of the present study suggest that the precedence effect is not a result of a poor sensitivity of the peripheral bottom-up processing. Rather, the precedence effect seems to be reflected by the MMN, i.e., cognitive processes on higher stages of the auditory pathway. (c) 2005 Elsevier B.V. All rights reserved.
C1 Carl Von Ossietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
RP Damaschke, J (reprint author), Carl Von Ossietzky Univ Oldenburg, D-26111 Oldenburg, Germany.
EM joerg.damaschke@uni-oldenburg.de
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NR 39
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 157
EP 171
DI 10.1016/j.heares.2005.03.014
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400016
PM 15953525
ER
PT J
AU Lopez-Poveda, EA
Plack, CJ
Meddis, R
Blanco, JL
AF Lopez-Poveda, EA
Plack, CJ
Meddis, R
Blanco, JL
TI Cochlear compression in listeners with moderate sensorineural hearing
loss
SO HEARING RESEARCH
LA English
DT Article
DE basilar membrane; cochlear compression; recovery from forward masking;
hearing loss; inner hair cell; outer hair cell
ID BASILAR-MEMBRANE NONLINEARITY; GUINEA-PIG COCHLEA; PERIPHERAL
COMPRESSION; CHINCHILLA COCHLEA; MOSSBAUER TECHNIQUE; RESPONSES; INNER;
FREQUENCIES; MECHANICS; REGION
AB Psychophysical estimates of basilar membrane (BM) responses suggest that normal-hearing (NH) listeners exhibit constant compression for tones at the characteristic frequency (CF) across the CF range from 250 to 8000 Hz. The frequency region over which compression occurs is broadest for low CFs. This study investigates the extent that these results differ for three hearing-impaired (HI) listeners with sensorineural hearing loss. Temporal masking curves (TMCs) were measured over a wide range of probe (500-8000 Hz) and masker frequencies (0.5-1.2 times the probe frequency). From these, estimated BM response functions were derived and compared with corresponding functions for NH listeners. Compressive responses for tones both at and below CF occur for the three HI ears across the CF range tested. The maximum amount of compression was uncorrelated with absolute threshold. It was close to normal for two of the three HI ears, but was either slightly (at CFs <= 1000 Hz) or considerably (at CFs >= 4000 Hz) reduced for the third ear. Results are interpreted in terms of the relative damage to inner and outer hair cells affecting each of the HI ears. Alternative interpretations for the results are also discussed, some of which cast doubts on the assumptions of the TMC-based method and other behavioral methods for estimating human BM compression. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Salamanca, Inst Neurociencias Castilla & Leon, Salamanca 37007, Spain.
Univ Essex, Dept Psychol, Colchester CO4 3SQ, Essex, England.
Oticon Espana SA, Alcobendas 28108, Madrid, Spain.
Soniotica SL, Albacete 02003, Spain.
RP Lopez-Poveda, EA (reprint author), Univ Salamanca, Inst Neurociencias Castilla & Leon, Ave Alfonso X El Sabio S-N, Salamanca 37007, Spain.
EM ealopezpoveda@usal.es
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NR 29
TC 31
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 172
EP 183
DI 10.1016/j.heares.2005.03.015
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400017
PM 15953526
ER
PT J
AU Green, KMJ
Julyan, PJ
Hastings, DL
Ramsden, RT
AF Green, KMJ
Julyan, PJ
Hastings, DL
Ramsden, RT
TI Auditory cortical activation and speech perception in cochlear implant
users: Effects of implant experience and duration of deafness
SO HEARING RESEARCH
LA English
DT Article
DE auditory cortex; cochlear implantation; cortical activation; positron
emission tomography; speech perception performance
ID POSITRON-EMISSION-TOMOGRAPHY; SOUND STIMULATION; FUNCTIONAL-ACTIVITY;
PET; CORTEX; BRAIN; PERFORMANCE; PREDICTORS; RESPONSES; LANGUAGE
AB This study aimed to investigate the relationship between outcome following cochlear implantation and auditory cortical activation. It also studied the effects of length of implant use and duration of deafness on the auditory cortical activations. Cortical activity resulting from auditory stimulation was measured using [F-18]FDG positron emission tomography. In a group of 18 experienced adult cochlear implant users, we found a positive correlation between speech perception and activations in both the primary and association auditory cortices. This correlation was present in a subgroup of experienced implant users but absent in a group of new implant users with similar speech perception abilities. There was a significant negative correlation between duration of deafness and auditory cortical activation. This study gives insights into the relationship between implant speech perception and auditory cortical activation and the influence of duration of preceding deafness and implant experience. (c) 2005 Elsevier B.V. All rights reserved.
C1 Manchester Royal Infirm, Dept Otolaryngol, Manchester, Lancs, England.
Christie Hosp, NW Med Phys, Manchester, Lancs, England.
Christie Hosp, Manchester PET Ctr, Manchester, Lancs, England.
RP Green, KMJ (reprint author), Manchester Royal Infirm, Dept Otolaryngol, Manchester, Lancs, England.
EM kmjgreen@rcsed.ac.uk
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NR 42
TC 38
Z9 43
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 184
EP 192
DI 10.1016/j.heares.2005.03.016
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400018
PM 15953527
ER
PT J
AU Choi, CH
Oghalai, JS
AF Choi, CH
Oghalai, JS
TI Predicting the effect of post-implant cochlear fibrosis on residual
hearing
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; intracochlear scarring; residual hearing; passive
cochlear model; damping
ID IMPLANT PERFORMANCE; ELECTRODE ARRAY; DEAFENED ADULTS; HAIR-CELLS;
MODEL; TRANSDUCTION; RECOGNITION
AB Intracochlear scarring is a well-described sequela of cochlear implantation. We developed a mathematical model of passive cochlear mechanics to predict the impact that this might have upon residual acoustical hearing after implantation. The cochlea was modeled using lumped impedance terms for scala vestibuli (SV), scala tympani (ST), and the cochlear partition (Cl?). The damping of ST and CP was increased in the basal one half of the cochlea to simulate the effect of scar tissue. We found that increasing the damping of the ST predominantly reduced basilar membrane vibrations in the apex of the cochlea while increasing the damping of the CP predominantly reduced basilar membrane vibrations in the base of the cochlea. As long as intracochlear scarring continues to occur with cochlear implantation, there will be limitations on hearing preservation. Newer surgical techniques and electrode technologies that do not result in as much scar tissue formation will permit improved hearing preservation. (c) 2005 Elsevier B.V. All rights reserved.
C1 Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, Houston, TX 77030 USA.
RP Oghalai, JS (reprint author), Baylor Coll Med, Bobby R Alford Dept Otolaryngol Head & Neck Surg, 1 Baylor Plaza,NA 102, Houston, TX 77030 USA.
EM cchoi@bcm.tmc.edu; jso@bcm.tmc.edu
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NR 24
TC 27
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 193
EP 200
DI 10.1016/j.heares.2005.03.018
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400019
PM 15953528
ER
PT J
AU Kim, TS
Nakagawa, T
Kitajiri, S
Endo, T
Takebayashi, S
Iguchi, F
Kita, T
Tamura, T
Ito, J
AF Kim, TS
Nakagawa, T
Kitajiri, S
Endo, T
Takebayashi, S
Iguchi, F
Kita, T
Tamura, T
Ito, J
TI Disruption and restoration of cell-cell junctions in mouse vestibular
epithelia following aminoglycoside treatment
SO HEARING RESEARCH
LA English
DT Article
DE inner ear; adherens junction; tight junction; aminoglycoside
ototoxicity; E-cadherin
ID EAR SENSORY EPITHELIA; MAMMALIAN INNER-EAR; E-CADHERIN; BETA-CATENIN;
HAIR-CELLS; REGENERATIVE PROLIFERATION; ADHESION MOLECULE; 2 MODES;
ORGAN; GENTAMICIN
AB The intracellular junction complexes, which consist of tight junctions (TJ), adherens junctions (AJ), and desmosomes, mediate cell-cell adhesion in epithelial cells. E-cadherin, which is a major component of AJ, plays a role not only in the maintenance of cell-cell junctions, but also in repressing cell proliferation. In this study, we examined changes of E-cadherin expression in mouse vestibular epithelia following local application of neomycin using immunohistochemistry and western blotting, and morphology of cell-cell junctions by transmission electron microscopy (TEM). Immunohistochemistry and western blotting revealed down-expression of E-cadherin and its consecutive recovery. TEM demonstrated temporal disruption of cell-cell junctions. Morphology of cell-cell junctions was more rapidly restored than recovery of E-cadherin expression. Transient disruption of cell-cell junctions and down-expression of E-cadherin is a rational response for the deletion of dying hair cells, and may be associated with a limited capacity for cell proliferations in mammalian vestibular epithelia following their rapid restoration. (c) 2005 Elsevier B.V. All rights reserved.
C1 Kyoto Univ, Grad Sch med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, Kyoto 6068507, Japan.
Kyoto Univ, Dept Cell Biol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan.
Kyoto Univ, Grad Sch Med, Horizontal Med Res Org, Sakyo Ku, Kyoto, Japan.
Japan Sci & Technol Corp, Solut Oriented Res Sci & Technol, Sakyo Ku, Kyoto 6068507, Japan.
RP Nakagawa, T (reprint author), Kyoto Univ, Grad Sch med, Dept Otolaryngol Head & Neck Surg, Sakyo Ku, 54 Shogoin, Kyoto 6068507, Japan.
EM kim@ent.kuhp.kyoto-u.ac.jp; tnakagawa@ent.kuhp.kyoto-u.ac.jp
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NR 43
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 201
EP 209
DI 10.1016/j.heares.2005.03.017
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400020
PM 15953529
ER
PT J
AU Carlyon, RP
van Wieringen, A
Deeks, JM
Long, CJ
Lyzenga, J
Wouters, J
AF Carlyon, RP
van Wieringen, A
Deeks, JM
Long, CJ
Lyzenga, J
Wouters, J
TI Effect of inter-phase gap on the sensitivity of cochlear implant users
to electrical stimulation
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; thresholds; inter-phase gap
ID PSYCHOPHYSICAL DETECTION THRESHOLDS; ACROSS-SPECIES COMPARISONS;
AUDITORY-NERVE; BALANCED STIMULI; INNER-EAR; SINGLE; DURATION;
PERCEPTION; RESPONSES; MODEL
AB Human behavioral thresholds for trains of biphasic pulses applied to a single channel of Nucleus CI24 and LAURA cochlear implants were measured as a function of inter-phase gap (IPG). Experiment 1 used bipolar stimulation, a 100-pps pulse rate, and a 400-ms stimulus duration. In one condition, the two phases of each pulse had opposite polarity. Thresholds continued to drop by 910 dB as IPG was increased from near zero to the longest value tested (2900 mu s for CI24, 4900 mu s for LAURA). This time course is much longer than reported for single-cell recordings from animals. In a second condition, the two phases of each pulse had the same polarity, which alternated from pulse to pulse. Thresholds were independent of IPG, and similar to those in condition 1 at IPG=4900 mu s. Experiment 2 used monopolar stimulation. One condition was similar to condition 1 of experiment 1, and thresholds also dropped up to the longest IPG studied (2900 mu s). This also happened when the pulse rate was reduced to 20 pps, and when only a single pulse was presented on each trial. Keeping IPG constant at 8 mu s and adding an extra biphasic pulse x ms into each period produced thresholds that were roughly independent of x, indicating that the effect of IPG in the other conditions was not due to a release from refractoriness at sites central to the auditory nerve. Experiment 3 measured thresholds at three IPGs, which were less than, equal to, and more than one half of the interval between successive pulses. Thresholds were lowest at the intermediate IPG. The results of all experiments could be fit by a linear model consisting of a lowpass filter based on the function relating threshold to the frequency of sinusoidal electrical stimulation. The data and model have implications for reducing the power consumption of cochlear implants. (c) 2005 Elsevier B.V. All rights reserved.
C1 MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England.
Katholieke Univ Leuven, Lab Exp ORL, B-3000 Louvain, Belgium.
RP Carlyon, RP (reprint author), MRC, Cognit & Brain Sci Unit, 15 Chaucer Rd, Cambridge CB2 2EF, England.
EM bob.carlyon@mrc-cbu.cam.ac.uk
RI Carlyon, Robert/A-5387-2010; Wouters, Jan/D-1800-2015
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NR 27
TC 25
Z9 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 210
EP 224
DI 10.1016/j.heares.2005.03.021
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400021
PM 15953530
ER
PT J
AU Spicer, SS
Schulte, BA
AF Spicer, SS
Schulte, BA
TI Pathologic changes of presbycusis begin in secondary processes and
spread to primary processes of strial marginal cells
SO HEARING RESEARCH
LA English
DT Article
DE ultrastructure; stria vascularis; aging; mitochondria; oxidation;
deafness
ID AGE-RELATED-CHANGES; SENSORINEURAL HEARING-LOSS; SPIRAL LIGAMENT
PATHOLOGY; AUDITORY-NERVE FIBERS; MOUSE INNER-EAR; COCHLEAR
DEGENERATION; INTERMEDIATE CELLS; GERBIL COCHLEA; ION-TRANSPORT;
VASCULARIS
AB Strial atrophy underlying age-related hearing loss was investigated by ultrastructural comparisons in young and senescent gerbils. In young animals strial marginal cells (MCs) projected primary processes which gave rise to and were connected by numerous ultrathin secondary processes. In 30-36-month-old gerbils, the MC secondary processes degenerated into lamellar or amorphous profiles as the first manifestation of strial atrophy. Some short primary processes shorn of projecting and connecting secondaries coalesced to form mitochondria-filled lobules. Strial involution appeared to progress with transformation of the degenerating processes and lobules into permanent residues of laminated amorphous substance. A second apparently unique form of degeneration was observed in which areas filled with homogeneous granular material replaced the processes that comprise the basal half of the normal MC. An abrupt line of transition separated this structureless degradation product below from the viable upper half of the MC. The terminally involuted stria consisted of MC bodies lining scala media, along with vestigial remnants of MC processes, nearby normal appearing intermediate cells (ICs) and unaltered basal cells. The only age-related change in ICs involved incorporation of melanosomes into very large, matrix-filled lysosomes. A profile of one MC in apparent necrosis provided evidence for an infrequent occurrence of MC death. These data support a progression of pathologic changes beginning with the demise of MC secondary processes and ending with ablation of secondary and primary processes. The initial injury apparently occurs as a result of oxidative self-damage to mitochondria in the MCs primary processes, leading to insufficient ATP for the Na, K-ATPase of the secondary processes. The reduced ATP level may cause cytotoxic alteration of the cytosolic Na+/K+ ratio first in MC secondary processes and later in the primaries, with consequent degeneration of these structures. (c) 2005 Elsevier B.V. All rights reserved.
C1 Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA.
RP Spicer, SS (reprint author), Med Univ S Carolina, Dept Pathol & Lab Med, 165 Ashley Ave,suite 309,Box 250908, Charleston, SC 29425 USA.
EM schulteb@musc.edu
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NR 43
TC 31
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 225
EP 240
DI 10.1016/j.heares.2005.03.022
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400022
PM 15953531
ER
PT J
AU van Ruijven, MWM
de Groot, JCMJ
Klis, SFL
Smoorenburg, GF
AF van Ruijven, MWM
de Groot, JCMJ
Klis, SFL
Smoorenburg, GF
TI The cochlear targets of cisplatin: An electrophysiological and
morphological time-sequence study
SO HEARING RESEARCH
LA English
DT Article
DE cisplatin ototoxicity; guinea pig; cochlea; spiral ganglion; organ of
Corti; histology; electrocochlcography
ID ALBINO GUINEA-PIG; INDUCED HEARING-LOSS; STRIA VASCULARIS; SPIRAL
GANGLION; CIS-DIAMMINEDICHLOROPLATINUM; INDUCED OTOTOXICITY; ACTH((4-9))
ANALOG; RECOVERY; RAT; PROTECTS
AB Cisplatin ototoxicity has at least three major targets in the cochlea: the stria vascularis, the organ of Corti, and the spiral ganglion. This study aims to differentiate between these three targets. In particular, we address the question of whether the effects at the level of the organ of Corti and spiral ganglion are mutually dependent or whether they develop in parallel. This question was approached by studying the ototoxic effects while they develop electrophysiologically and comparing these to earlier presented histological data [Van Ruijven et al., 2004. Hear. Res. 197, 44-54]. Guinea pigs were treated with intraperitoneal injections of cisplatin at a dose of 2 mg/kg/day for either 4, 6, or 8 consecutive days. This time sequence has not revealed any evidence of one ototoxic process triggering another. Therefore, we have to stay with the conclusion of Van Ruijven et al. (2004) that both processes run in parallel. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Utrecht, Med Ctr, Hearing Res Labs, Dept Otorhinolaryngol, NL-3508 GA Utrecht, Netherlands.
RP van Ruijven, MWM (reprint author), Univ Utrecht, Med Ctr, Hearing Res Labs, Dept Otorhinolaryngol, Room G-02-531,POB 85-500, NL-3508 GA Utrecht, Netherlands.
EM m.vanruijven@kmb.azu.nl
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NR 40
TC 46
Z9 49
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 241
EP 248
DI 10.1016/j.heares.2005.03.023
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400023
PM 15953532
ER
PT J
AU Jedrzejczak, WW
Blinowska, KJ
Konopka, W
AF Jedrzejczak, WW
Blinowska, KJ
Konopka, W
TI Time-frequency analysis of transiently evoked otoacoustic emissions of
subjects exposed to noise
SO HEARING RESEARCH
LA English
DT Article
DE transiently evoked otoacoustic emissions; noise exposure; time-frequency
distribution; adaptive approximations
ID NORMAL-HEARING; NORMAL EARS; CLICK
AB Transiently evoked otoacoustic emissions (TEOAE) were measured from 124 ears from two subject groups: healthy subjects (62 ears), and workers (62 ears) exposed to noise of jet engines. The recordings were analyzed using the method of adaptive approximations based on a matching pursuit (MP) algorithm. The method allows for description of the signal components in terms of their amplitude, frequency, latency, and time-span (or duration). The purpose of this work was to determine the repeatability and usefulness of these parameters in studies of hearing impairment of populations exposed to potentially harmful noise. Good distinction between the two datasets was achieved in all investigated frequency bands when amplitude was used as a discrimination parameter. Also latency was affected in frequency bands starting at 2000 Hz, while the time-span parameter associated with the duration of the waveform was less influenced by noise. (c) 2005 Elsevier B.V. All rights reserved.
C1 Warsaw Univ, Inst Phys Expt, Dept Biomed Phys, PL-00681 Warsaw, Poland.
Med Univ Lodz, Dept Otolaryngol, PL-90549 Lodz, Poland.
RP Blinowska, KJ (reprint author), Warsaw Univ, Inst Phys Expt, Dept Biomed Phys, Ul Hoza 69, PL-00681 Warsaw, Poland.
EM katarzyna.blinowska@fuw.edu.pl
RI Konopka, Wieslaw/P-2401-2014
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NR 10
TC 34
Z9 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 249
EP 255
DI 10.1016/j.heares.2005.03.024
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400024
PM 15953533
ER
PT J
AU Soeta, Y
Nakagawa, S
Tonoike, M
AF Soeta, Y
Nakagawa, S
Tonoike, M
TI Auditory evoked magnetic fields in relation to iterated rippled noise
SO HEARING RESEARCH
LA English
DT Article
DE magnetoencephalography; auditory evoked response; Nlm; iterated rippled
noise; autocorrelation function
ID PITCH STRENGTH; TONOTOPIC ORGANIZATION; COMPLEX SOUNDS; HUMAN BRAIN;
CORTEX; REPRESENTATION; MAGNETOENCEPHALOGRAPHY; SENSITIVITY; RECORDINGS;
PERIPHERY
AB Auditory evoked magnetic fields in relation to iterated rippled noise (IRN) were examined by magnetoencephalography (MEG). IRN was used as the sound stimulus to control the peak amplitude of the autocorrelation function of the sound. The IRN was produced by a delay-and-add algorithm applied to bandpass noise that was filtered using fourth-order Butterworth filters between 4002200 Hz. All sound signals had the same sound pressure level. The stimulus duration was 0.5 s, with rise and fall ramps of 10 ms. Ten normal-hearing subjects took part in the study. Auditory evoked fields were recorded using a 122 channel whole-head magnetometer in a magnetically shielded room. The results showed that the peak amplitude of N1m, which was found above the left and right temporal lobes around 100 ms after the stimulus onset, increased with increase in the number of iterations of the IRN. The latency and estimated equivalent current dipole (ECD) locations of N1m did not show any systematic variation as a function of the number of iterations. (c) 2005 Elsevier B.V. All rights reserved.
C1 Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
RP Soeta, Y (reprint author), Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
EM y.soeta@aist.go.jp
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NR 30
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 256
EP 261
DI 10.1016/j.heares.2005.03.026
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400025
PM 15953534
ER
PT J
AU Iida, K
Tsumoto, K
Ikeda, K
Kumagai, I
Kobayashi, T
Wada, H
AF Iida, K
Tsumoto, K
Ikeda, K
Kumagai, I
Kobayashi, T
Wada, H
TI Construction of an expression system for the motor protein prestin in
Chinese hamster ovary cells
SO HEARING RESEARCH
LA English
DT Article
DE outer hair cell; prestin; Chinese hamster ovary cell; cloning; stable
expression
ID OUTER HAIR-CELLS; MECHANICAL RESPONSES; COCHLEAR AMPLIFIER; VOLTAGE
SENSOR; MEMBRANE; CAPACITANCE; MOTILITY
AB The electromotility of outer hair cells (OHCs) is believed to be a major factor in cochlear amplification that enables the high sensitivity of hearing in mammals. This motility is thought to be based on voltage-dependent conformational changes of a motor protein embedded in the lateral wall of the OHC. In 2000, this motor protein was identified and termed prestin. To obtain knowledge on the function of prestin, research at the molecular level is necessary. For this purpose, a method of obtaining a large amount of prestin is required. In this study, an attempt was therefore made to construct an expression system for prestin. Prestin cDNA was introduced into Escherichia coli (E. coli), insect cells and Chinese hamster ovary (CHO) cells, and the expression of prestin was examined by Western blotting. As CHO cells expressed prestin well, we generated prestin-expressing cell lines using CHO cells by limiting dilution cloning. The stable expression and the activity of prestin in generated cell lines were then confirmed. Finally, to obtain prestin from these cell lines efficiently, culture conditions of the cells were examined, and it was clarified that cells should be cultured in serum-free medium and harvested around 48 h after passage. (c) 2005 Elsevier B.V. All rights reserved.
C1 Tohoku Univ, Detp Bioengn & Robot, Sendai, Miyagi 9808579, Japan.
Tohoku Univ, Dept Biomol Engn, Sendai, Miyagi 9808579, Japan.
Juntendo Univ, Sch Med, Dept Otorhinolaryngol, Bunkyo Ku, Tokyo 1138421, Japan.
Tohoku Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Sendai, Miyagi 9808575, Japan.
RP Wada, H (reprint author), Tohoku Univ, Detp Bioengn & Robot, 6-6-01 Aoba Yama, Sendai, Miyagi 9808579, Japan.
EM wada@cc.mech.tohoku.ac.jp
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NR 20
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 262
EP 270
DI 10.1016/j.heares.2005.03.027
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400026
PM 15953535
ER
PT J
AU Liu, YX
Li, XP
Ma, CS
Liu, JX
Lu, H
AF Liu, YX
Li, XP
Ma, CS
Liu, JX
Lu, H
TI Salicylate blocks L-type calcium channels in rat inferior colliculus
neurons
SO HEARING RESEARCH
LA English
DT Article
DE calcium currents; inferior colliculus; patch clamp; salicylate; tinnitus
ID HIPPOCAMPAL-NEURONS; CA2+ CHANNELS
AB To investigate the effects of the tinnitus inducer sodium salicylate on L-type voltage-gated calcium channels, we studied freshly (-)dissociated inferior colliculus neurons of rats by the whole-cell voltage clamp method. Salicylate's blocking of L-type calcium Channels was concentration dependent, and the IC50 value of salicylate was estimated to be 1.99 mM. An amount of 1 mM salicylate significantly shifted the steady-state inactivation curve of L-type calcium channels about 9mV in the hyperpolarizing direction and significantly delayed calcium channel recovery. Our results suggest that salicylate's blocking of L-type calcium channels may contribute to salicylate-induced tinnitus by decreasing GABA release in the inferior colliculus. (c) 2005 Elsevier B.V. All rights reserved.
C1 Peking Univ, Third Hosp, Dept Otorhinolaryngol, Beijing 100083, Haidian Dist, Peoples R China.
Hebei Med Univ, Dept Neurobiol, Shijiazhuang 050017, Peoples R China.
Hebei Med Univ, Hosp 2, Dept Otorhinolaryngol, Shijiazhuang 050000, Peoples R China.
RP Li, XP (reprint author), Peking Univ, Third Hosp, Dept Otorhinolaryngol, 49 Huayuan Rd, Beijing 100083, Haidian Dist, Peoples R China.
EM liuyanxing75@sohu.com; drlixuepei@sohu.com
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NR 20
TC 20
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 271
EP 276
DI 10.1016/j.heares.2005.03.028
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400027
PM 15953536
ER
PT J
AU Yang, TH
Young, YH
AF Yang, TH
Young, YH
TI Click-evoked myogenic potentials recorded on alert guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE guinea pigs; vestibular evoked myogenic potential; clip electrode;
caloric nystagmus
ID NECK; RESPONSES; MUSCLES; RAT
AB The aim of this study was to establish an animal model of acoustically evoked vestibulo-collie reflex using guinea pigs. A special clamp was applied to restrain the head and body of the guinea pigs, but leaving its four legs free. Each animal underwent vestibular evoked inyogenic potential (VEMP) and caloric tests using clip electrode method without general anesthesia or decerebrate surgery. The response rates for the myogenic potentials on the neck of guinea pigs using 100, 90, 80 and 70 dB monaural acoustic stimulation with unilateral recording were 100%, 62%, 50'% and 0%, respectively. The mean latencies of the positive and negative peaks for the myogenic potentials were 7.24 +/- 0.49 and 9.15 +/- 10.47 ms, 7.09 +/- 0.43 and 9.28 +/- 0.42 ins, as well as 7.03 +/- 0.59 and 9.14 +/- 0.56 ms, when elicited by 100, 90 and 80 dB acoustic stimulation, respectively. The median (minimum-maximum) peak-to-peak amplitudes were 11.93 (6.14-16.86), 10.99 (5.28-19.40), and 11.17 (5.02-20.72) mu V, when elicited by 100, 90 and 80 dB acoustic stimulation, respectively. We found no significant relationship between the stimulus intensity and the mean latencies or peak-to-peak amplitude of the myogenic potentials in guinea pigs. For those treated with gentamicin unilaterally, all guinea pigs showed absent caloric responses on the lesion side, and absent myogenic potentials on the neck when using ipsi-lesional acoustic stimulation, while the hearing was preserved. Hence, the use of gentamicin-treated animals, along with normal controls and auditory brainstem responses, results in convincing results that the recorded myogenic potentials are in fact of vestibular origin. (c) 2005 Elsevier B.V. All rights reserved.
C1 Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan.
Natl Taiwan Univ, Coll Med, Taipei 10018, Taiwan.
RP Young, YH (reprint author), Natl Taiwan Univ Hosp, Dept Otolaryngol, 1 Chang Te St, Taipei, Taiwan.
EM youngyh@ha.mc.mu.edu.tw
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NR 16
TC 18
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUL
PY 2005
VL 205
IS 1-2
BP 277
EP 283
DI 10.1016/j.heares.2005.03.029
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 941UJ
UT WOS:000230239400028
PM 15953537
ER
PT J
AU Reyes, SA
Lockwood, AH
Salvi, RJ
Coad, ML
Wack, DS
Burkard, RF
AF Reyes, SA
Lockwood, AH
Salvi, RJ
Coad, ML
Wack, DS
Burkard, RF
TI Mapping the 40-Hz auditory steady-state response using current density
reconstructions
SO HEARING RESEARCH
LA English
DT Article
DE auditory steady-state response; source localization; auditory pathways;
evoked potentials; LORETA; MinNorm
ID AMPLITUDE-MODULATED TONES; 40 HZ; EVOKED-POTENTIALS; CORTEX; FREQUENCY;
PHASE; ACTIVATION; ATTENTION; HUMANS; FIELDS
AB We mapped the 40-Hz aSSR from nine normal subjects using PET-independent low-resolution electroencephalographic tomography (LORETA) as well as PET-weighted LORETA and minimum norm (MinNorm) current density reconstructions. In grand mean data, PET-independent LORETA identified seven sites with peaks in current density in right temporal lobe, right brainstem/cerebellum, right parietal lobe, left cerebellum/temporal lobe, and right frontal lobe. PET-weighted LORETA found six of the same sites as the PET-independent LORETA: the right brainstem source was eliminated and two right-frontal sources were added. Both LORETA analyses revealed considerable phase dispersion across identified sources. In both LORETA analyses, the relative time course of activation measured from an arbitrary starting phase progressed from right temporal lobe to right mid-frontal lobe to right parietal-frontal to right inferior parietal and finally to left cerebellum and left temporal lobe. MinNorm analysis incorporating PET information identified sources in the same locations as specified in the PET data. These sources were synchronized, with their amplitudes peaking almost simultaneously.
Both PET-independent and PET-weighted LORETA results suggest that the aSSR is: (1) the result of a reverberating network with two or more groups of sources that recurrently excite each other or (2) the result of sequential auditory processing through various levels of a hierarchical network. In contrast, the PET-weighted MinNorm results suggest that the 40-Hz response represents simultaneous activation over widely spaced areas of the brain, perhaps due to synchronization of gamma-band activity to a common neural clock. (c) 2004 Published by Elsevier B.V.
C1 SUNY Buffalo, Dept Commun Sci & Disorders, Buffalo, NY 14214 USA.
SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
SUNY Buffalo, Sch Med & Biomed Sci, Buffalo, NY 14214 USA.
Vet Adm Western New York Healthcare Syst, Ctr Positron Emiss Tomog, Buffalo, NY 14214 USA.
SUNY Buffalo, Dept Neurol, Buffalo, NY 14214 USA.
SUNY Buffalo, Ctr Positron Emiss Tomog, Buffalo, NY 14214 USA.
SUNY Buffalo, Dept Nucl Med, Buffalo, NY 14214 USA.
SUNY Buffalo, Dept Otolaryngol, Buffalo, NY 14214 USA.
VA Western NY Healthcare Syst, Buffalo, NY 14215 USA.
RP Reyes, SA (reprint author), Univ Miami, Dept Otolaryngol, Miami, FL 33101 USA.
EM reyes@myrealbox.com; rfb@acsu.buffalo.edu
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NR 44
TC 5
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 1
EP 15
DI 10.1016/j.heares.2004.11.016
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200001
PM 15925187
ER
PT J
AU Rose, MM
Moore, BCJ
AF Rose, MM
Moore, BCJ
TI The relationship between stream segregation and frequency discrimination
in normally hearing and hearing-impaired subjects
SO HEARING RESEARCH
LA English
DT Article
DE stream segregation; frequency discrimination; hearing impairment;
perceptual grouping
ID SPEECH RECEPTION; ELDERLY SUBJECTS; TONE SEQUENCES; GAP DETECTION;
LISTENERS; NOISE; INTELLIGIBILITY; SELECTIVITY; SENTENCES; LOUDNESS
AB We examined the relationship between the fission boundary (FB) at which a sequence of pure tones alternating between two frequencies cannot be heard as two separate streams and the frequency difference limen (FDL), using normally hearing subjects and subjects with cochlear hearing loss. The stimuli used in the two tasks were as similar as possible in duration and inter-tone interval. The frequency range examined was 250-8000 Hz for the normally hearing subjects and 250-2000 Hz for the hearing-impaired subjects. For normally hearing subjects, the FBs were almost invariant with frequency when expressed as ERBN values; the mean FB was about 0.4 ERBN. The FDLs, also expressed as ERBN values, increased for frequencies above 2000 Hz. The ratio FB/FDL was roughly constant at 7-9 in the frequency region 250-2000 Hz, but decreased for higher frequencies, reaching about 1 at 8000 Hz. For the hearing-impaired subjects, FB/FDL ratios varied over a large range (1-40), and were not systematically related to the amount of hearing loss. These results suggest that the FB is not determined solely by the discriminability of successive tones. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
RP Rose, MM (reprint author), Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England.
EM rosemm@aston.ac.uk
RI Moore, Brian/I-5541-2012
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NR 39
TC 20
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 16
EP 28
DI 10.1016/j.heares.2004.12.004
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200002
PM 15925188
ER
PT J
AU Bibikov, NG
Elepfandt, A
AF Bibikov, NG
Elepfandt, A
TI Auditory evoked potentials from medulla and midbrain in the clawed frog,
Xenopus laevis laevis
SO HEARING RESEARCH
LA English
DT Article
DE frog; Xenopus; auditory evoked potential; click rate; audiogram; pulse
shape
ID ANURAN AMPHIBIANS; LATERAL-LINE; UNDERWATER HEARING; HYLA-VERSICOLOR;
GRAY TREEFROG; BRAIN; SENSITIVITY; COMMUNICATION; TEMPERATURE; BULLFROG
AB Auditory evoked potentials (AEPs) to clicks and tonal pulses were recorded from medulla and midbrain in Xenopus laevis laevis. They comprise three components: an initial peak (I) at 2.2-3 ms latency, a fast series of peaks (F) at 5-15 ins latency, and a slow negative wave (S) at 20-40 ins latency. In medullary recordings, the initial peak was largest, whereas in inidbrain recordings typically the two other components prevailed. For all components and animals, response threshold at 4 clicks/s was approximately 69 dB SPL. In response to tonal stimuli, AEP amplitudes were maximal at 1.3-2.0 and 3.5 kHz. Raising the click rate to 100/s gradually reduced the amplitude of the I and the first F peaks, whereas later F peaks and the S wave Virtually disappeared at 20-40 clicks/s. On the other hand. extending the plateau duration of tonal stimuli from 4 to 10 ins hardly affected the I and F peaks but doubled the S amplitude. This suggests two systems for stimulus processing, a fast system capable to follow clicks LIP to high repetition rates and a slow system with longer integration time. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Konstanz, Fak Biol, D-7750 Constance, Germany.
Acoust Acad Sci, NN Andreev Acoust Inst, Moscow, Russia.
Humboldt Univ, Inst Biol, D-10115 Berlin, Germany.
RP Elepfandt, A (reprint author), Univ Konstanz, Fak Biol, D-7750 Constance, Germany.
EM andreas.elepfandt@rz.hu-berlin.de
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NR 37
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 29
EP 36
DI 10.1016/j.heares.2004.12.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200003
PM 15925189
ER
PT J
AU Richardson, RT
O'Leary, S
Wise, A
Hardman, J
Clark, G
AF Richardson, RT
O'Leary, S
Wise, A
Hardman, J
Clark, G
TI A single dose of neurotrophin-3 to the cochlea surrounds spiral ganglion
neurons and provides trophic support
SO HEARING RESEARCH
LA English
DT Article
DE neurotrophin; cochlea; sensorineural hearing loss; spiral ganglion
neurons; I-125; autoradiography
ID NERVE GROWTH-FACTOR; RETROGRADE AXONAL-TRANSPORT; RAT SYMPATHETIC
NEURONS; HAIR CELL LOSS; ELEMENTS FOLLOWING DISRUPTION; GUINEA-PIG
COCHLEA; AUDITORY NEURONS; ULTRASTRUCTURAL CHANGES;
HORSERADISH-PEROXIDASE; COMPARTMENTED CULTURES
AB Degeneration of spiral ganglion neurons (SGNs) in the cochlea following sensorineural hearing loss is preventable by the infusion of neurotrophins into the scala tympani. This study investigates the trophic effects and distribution of a single bolus infusion of neurotrophin-3 (NT3) into the scala tympani of the cochlea. The left cochleae of 28-day deafened guinea pigs were infused with 0, 100 or 140 ng I-125 NT3 via a cochleostomy in the scala tympani of the basal turn. Seven days post-infusion, cochlear sections were processed for measurements of trophic effect's on SGNs and autoradiography. A single infusion of NT3 increased the soma size of SGNs in a dose-dependent and significant manner but did not contribute to SGN survival. Following infusion of 140ng I-125 NT3 into the cochlea, 0.31% of the total I-125 NT3 signal in the basal turn was detected in Rosenthal's canal, 2.4% was in peripheral processes and 0.35% was in the modiolar auditory nerve. Despite influencing SGN soma size, I-125 NT3 was not observed to accumulate in SGN cell bodies. The data suggest that only a small proportion of neurotrophins infused into the scala tympani diffuses to the SGNs and their processes and produces trophic effects on SGN cell bodies. (c) 2005 Elsevier B.V. All rights reserved.
C1 Bion Ear Inst, Melbourne, Vic 3002, Australia.
Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
RP Richardson, RT (reprint author), Bion Ear Inst, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM rrichardson@bionicear.org
RI Wise, Andrew/B-5943-2014
OI Wise, Andrew/0000-0001-9715-8784
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NR 45
TC 35
Z9 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 37
EP 47
DI 10.1016/j.heares.2005.01.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200004
PM 15925190
ER
PT J
AU Smittkamp, SE
Girod, DA
Durham, D
AF Smittkamp, SE
Girod, DA
Durham, D
TI Role of cochlear integrity in cochlear nucleus glucose metabolism and
neuron number after cochlea removal in aging broiler chickens
SO HEARING RESEARCH
LA English
DT Article
DE auditory; avian; deafferentation; nucleus magnocellularis
ID STEM AUDITORY NUCLEI; CYTOCHROME-OXIDASE ACTIVITY; NERVE
ELECTRICAL-ACTIVITY; BRAIN-STEM; AFFERENT INFLUENCES; CELL-DEATH; BREED
DIFFERENCES; VISUAL-SYSTEM; ADULT MONKEYS; RAPID CHANGES
AB In the chicken auditory system, cochlear nucleus (nucleus magnocellularis, NM) neurons receive their only excitatory input from the ipsilateral cochlea. Cochlea removal (CR) results in an immediate decrease in NM neuron electrical activity, followed by death of similar to 30% of NM neurons. Previous work showed a decrease in NM activity and subsequent loss of NM neurons in all chicks. Egg layer adults showed NM neuron loss after CR, while neuron number remained stable in broiler adults. This suggested that effects of CR on NM were age- and breed-dependent. We now know that most aging egg layer chickens maintain largely normal cochleae throughout adulthood. Some exhibit cochlear damage with age. The converse is true of broiler chickens. Most aging broiler chickens display cochlear degeneration, with some maintaining normal cochlear anatomy throughout adulthood. The presence of extensive cochlear damage may alter the effect of CR on NM, leading to the described differences. Here, we examine the effect of unilateral CR on NM glucose metabolism and neuron number in 2, 30, 39, and 52 week-old broiler chickens found to have normal cochleae. Chickens with damaged cochleae were excluded. Using 2-deoxyglucose uptake to evaluate bilateral NM glucose metabolism, we found significantly decreased uptake ipsilateral to CR at each age examined. Bilateral cell counts revealed significant neuron loss ipsilateral to CR at each age examined. This suggests that NM glucose metabolism decreases and subsequent neuron death occurs in aging broiler chickens when a normal cochlea is removed. The status of the cochlea must play a role in the effect of deafferentation on NM glucose metabolism and neuron survival. The effect of CR appears to be dependent upon neither age nor breed, but upon cochlear integrity instead. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, Smith Mental Retardat Res Ctr, Kansas City, KS 66160 USA.
Univ Kansas, Med Ctr, Dept Speech & Hearing, Smith Mental Retardat Res Ctr, Kansas City, KS 66160 USA.
RP Durham, D (reprint author), Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, Smith Mental Retardat Res Ctr, 3901 Rainbow Blvd,MS 3010, Kansas City, KS 66160 USA.
EM ddurham@kume.edu
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NR 47
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 48
EP 59
DI 10.1016/j.heares.2004.12.011
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200005
PM 15925191
ER
PT J
AU Nakajima, HH
Ravicz, ME
Merchant, SN
Peake, WT
Rosowski, JJ
AF Nakajima, HH
Ravicz, ME
Merchant, SN
Peake, WT
Rosowski, JJ
TI Experimental ossicular fixations and the middle ear's response to sound:
Evidence for a flexible ossicular chain
SO HEARING RESEARCH
LA English
DT Article
DE middle-ear function; sound-induced ossicular motion; middle-ear
pathology; evolution of the middle ear
ID DOPPLER VIBROMETER LDV; TYMPANIC MEMBRANE; MALLEUS FIXATION; HEARING;
EVOLUTION; TRANSMISSION; WINDOWS; EARDRUM; MOTION; MODEL
AB A human temporal-bone preparation was used to determine the effects of various degrees of artificial ossicular fixation on the sound-induced velocity at the input-side (the umbo of the malleus) and the output-side (the stapes) of the ossicular chain. Construction of various degrees of attachment between an ossicle and the surrounding temporal bone provided a range of reduction in ossicular mobility or "fixations". The results demonstrate different effects of the fixations on the umbo and stapes velocity: fixations of the stapes or incus produce larger reductions in sound-induced stapes velocity (as much as 40-50 dB with extensive stapes fixation), than reductions in umbo velocity (typically less than 10 dB). Fixations of the malleus produce similar-sized changes in both umbo and stapes velocity. These differential effects are consistent with significant flexibility in the ossicular joints (the incudo-malleolar joint and the incudo-stapedial joint) that permits relative motion between the coupled ossicles. The existence of flexibility in the ossicular joints indicates that joints in the ossicular chain can effect a loss of sound-induced mechanical energy between the umbo and the stapes, with a concomitant reduction in the sound-induced motion of the stapes. The introduction of such losses in sound transmission by the joints raises questions concerning the utility of three ossicles in the mammalian ear. The consequences of ossicular flexibility to ossicular-chain reconstruction is discussed. Also, as examined in a more clinically directed paper [Laryngoscope 115 (2005) 147], the different effects of the various ossicular fixations on the motion of the umbo and malleus may be useful in the diagnosis of the site of fixations in humans with conductive hearing losses caused by such pathologies. (c) 2005 Elsevier B.V. All rights reserved.
C1 Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
MIT, Elect Res Lab, Cambridge, MA 02139 USA.
Harvard Univ, MIT, Speech & Hearing Biosci & Technol Program, Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
RP Rosowski, JJ (reprint author), Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
EM john_rosowski@meei.harvard.edu
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NR 52
TC 45
Z9 46
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 60
EP 77
DI 10.1016/j.heares.2005.01.002
PG 18
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200006
PM 15925192
ER
PT J
AU Gordon, KA
Papsin, BC
Harrison, RV
AF Gordon, KA
Papsin, BC
Harrison, RV
TI Effects of cochlear implant use on the electrically evoked middle
latency response in children
SO HEARING RESEARCH
LA English
DT Article
DE deafness; congenital; pre-lingual; peri-lingual; evoked potentials;
electrical stimulation; sensitive periods; auditory; human; children;
thalamus; cortex; synchrony; development; plasticity
ID PRELINGUALLY DEAF-CHILDREN; AUDITORY BRAIN-STEM; SPEECH-PERCEPTION
ABILITIES; GRADED-PROFILE-ANALYSIS; CROSS-MODAL PLASTICITY; CONGENITALLY
DEAF; SIGN-LANGUAGE; INFERIOR COLLICULUS; GENERATING-SYSTEM;
HEARING-LOSS
AB The electrically evoked middle latency response (eMLR) reflects central auditory activity in cochlear implant users. This response was recorded repeatedly in 50 children over the first year of cochlear implant use and in 31 children with 5.3 +/- 2.9 years of implant experience. The eMLR was rarely detected at the time of implantation in anaesthetized or sedated children and was detected in only 35% of awake children at initial device stimulation. The detectability of the eMLR increased over the first year of implant use becoming 100%, detectable in children after at least one year. Acutely evoked responses were more likely to be present in older children despite longer periods of auditory deprivation. Within six months of implant use. most children had detectable eMLRs. At early stages of device use, eMLR amplitudes were lower in children implanted below the age of 5 years compared to children implanted at older ages; amplitudes increased over time in both groups. Latencies after six months of implant use were prolonged in the Younger group and decreased with implant use. EMLR changes with chronic cochlear implant use suggest an activity-dependent plasticity of the central auditory system. Results suggest that the pattern of electrically evoked activity and development in the auditory thalamo-cortical pathways will be dependent upon the duration or auditory deprivation Occurring in early childhood. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Toronto, Hosp Sick Children, Dept Otolaryngol, Toronto, ON M5G 1X8, Canada.
Univ Toronto, Hosp Sick Children, Brain & Behav Program, Toronto, ON M5G 1X8, Canada.
RP Gordon, KA (reprint author), Univ Toronto, Hosp Sick Children, Dept Otolaryngol, 100 Coll St, Toronto, ON M5G 1X8, Canada.
EM karen.gordon@utoronto.ca
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NR 62
TC 24
Z9 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 78
EP 89
DI 10.1016/j.heares.2005.01.003
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200007
PM 15925193
ER
PT J
AU Harding, GW
Bohne, BA
Vos, JD
AF Harding, GW
Bohne, BA
Vos, JD
TI The effect of an age-related hearing loss gene (Ahl) on noise-induced
hearing loss and cochlear damage from low-frequency noise
SO HEARING RESEARCH
LA English
DT Article
DE Ahl gene; TTS; PTS; ABR; DPOAE; histopathology; C57BL/6J; B6.CAST
ID PRODUCT OTOACOUSTIC EMISSIONS; MOUSE COCHLEA; F1-HYBRID STRAINS;
ACOUSTIC TRAUMA; C57BL/6J MICE; OCTAVE BANDS; EXPOSURE; SUSCEPTIBILITY;
DEGENERATION; SENSITIVITY
AB Inbred C57BL/6J mice carry two copies of an age-related hearing loss gene (Ahl). It has been shown that these mice begin losing high-frequency hearing at two months. Several functional studies have reported that the AN gene renders mice more susceptible to noise-induced hearing loss (NIHL) than strains which do not carry this gene [e.g., Hear. Res. 93 (1996) 181 ;, Hear. Res. 155 (2001) 81 J. Assoc. Res. Otolaryngol. 2 (2001) 233]. Johnson et al. [Hear. Res. 114 (1997) 83] developed a congenic B6.CAST-+(Ahl) mouse which carries the wild-type allele from Mus musculus castancus at the Ahl locus. Five cacti of young C57BL/6J males and females, and B6.CAST- +(Ahl) males were exposed to a 4-kHz octave band of noise at 108 dB SPL for 4 It. Non-noise-exposed mice of the same strains and age served as controls. The noise-exposed mice were functionally tested for ABR thresholds and DPOAE levels pre-exposure and three times post-exposure: 0 days to determine the magnitude of temporary threshold shift (TTS); 6 days to determine rate of recovery; and 20 days to determine the magnitude of permanent threshold shift (PTS). At 20 days post-exposure, the animals underwent cardiac perfusion to fix their cochleae. The isolated cochleae were embedded in plastic and dissected into flat preparations. By phase-contrast microscopy, each cochlea was evaluated from apex to base to quantify the losses of hair cells, nerve fibers and stria vascularis and to localize stereocilia damage. Functional data from each mouse were aligned with the cytocochleogram using the frequency-place map of Ou et al. [Hear. Res. 145 (2000) 111; Hear. Res. 145 (2000) 123]. Sizable variation in the magnitude of TTS, PTS and hair-cell loss was found among mice of the same genetic strain. The congenic B6.CAST-+(Ahl) male mice had significantly less TTS immediately post-exposure than C57BL/6J males or females but not less PTS or hair-cell losses at 20 days post-exposure. These results indicate that, at one month of age, mice carrying two copies of the AN gene have an increased susceptibility to TTS from a low-frequency noise before they have any indication of age-related hearing or hair-cell loss. However, this appeared not to be the case for PTS. The AN gene appears to play a role in susceptibility to NIHL but, other genes as well as systemic and local factors must also be involved. (c) 2005 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Harding, GW (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, Box 8115, St Louis, MO 63110 USA.
EM hardingg@wustl.edu
RI Bohne, Barbara/A-9113-2008; Legarth, Jonas/A-9156-2012
OI Bohne, Barbara/0000-0003-3874-7620;
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NR 37
TC 27
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 90
EP 100
DI 10.1016/j.heares.2005.01.004
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200008
PM 15925194
ER
PT J
AU Hawley, ML
Melcher, JR
Fullerton, BC
AF Hawley, ML
Melcher, JR
Fullerton, BC
TI Effects of sound bandwidth on fMRI activation in human auditory
brainstem nuclei
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 25th Midwinter Research Meeting of the
Association-for-Research-in-Otolaryngology
CY JAN 27-31, 2002
CL ST PETERSBURG, FL
SP Assoc Res Otolaryngol
DE functional imaging; human auditory processing; cochlear nucleus;
superior olivary complex; inferior colliculus
ID INFERIOR COLLICULUS; SENSORY STIMULATION; ACOUSTIC NOISE; SCANNER NOISE;
STIMULUS RATE; TIME-COURSE; CORTEX; FREQUENCY; SIGNAL; TONES
AB Few neuro-imaging studies of the auditory system have examined the dependence of brain activation on sound bandwidth, a fundamental stimulus parameter, and none have examined bandwidth dependencies in the brainstem. The present study examined the effect of bandwidth on human brainstem activation using fMRI, an indicator Of Population neural activity. The studied stimuli (broadband, two-. one-. and third-octave continuous noise) activated three brainstem centers: cochlear nucleus, superior olivary complex, and inferior colliculus. Activation could be confidently attributed to these nuclei because it was appropriately punctate (given the small size of the imaged nuclei) and appropriately located (as determined from histological atlases). Activation in all three imaged centers increased monotonically with increasing bandwidth when either Stimulus spectrum level or energy was held constant. Supplementary experiments indicated that the measured bandwidth dependencies were not contaminated by the extraneous sounds produced by the scanner. Increases in fMRI activation with increasing bandwidth would be expected from Populations of neurons having a single best frequency and only excitatory responses to sound, but not necessarily from lower auditory system neurons with their often more complex responses. Our results provide basic information for designing auditory neuro-imaging studies that need to control for, or manipulate sound bandwidth. (c) 2005 Elsevier B.V. All rights reserved.
C1 Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA.
MIT, Harvard Mit Div Hlth Sci & Technol, Speech & Hearing Biosci & Technlol Program, Cambridge, MA 02139 USA.
Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
RP Melcher, JR (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, 243 Charles St, Boston, MA 02114 USA.
EM jrm@epi.meei.harvard.edu
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NR 35
TC 23
Z9 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 101
EP 110
DI 10.1016/j.heares.2005.01.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200009
PM 15925195
ER
PT J
AU Basta, D
Todt, I
Eisenschenk, A
Ernst, A
AF Basta, D
Todt, I
Eisenschenk, A
Ernst, A
TI Vestibular evoked myogenic potentials induced by intraoperative
electrical stimulation of the human inferior vestibular nerve
SO HEARING RESEARCH
LA English
DT Article
DE vestibulocollic reflex; VEMP; inferior vestibular nerve; intraoperative
neurophysiologic monitoring
ID GALVANIC STIMULATION; GUINEA-PIG; RESPONSES; REFLEX; DEAFFERENTATION;
PRESERVATION; NEURONS; SURGERY; SYSTEM; SOUND
AB Vestibular evoked myogenic potentials (VEMPs) can be recorded from sternocleidomastoid muscle (SCM) in clinical practice. The aim of the present Study was to investigate VEMPs upon direct electrical stimulation of the human inferior vestibular nerve to evidence the vestibulocollic reflex arch and their saccular origin, respectively.
Seven subjects were stimulated at the inferior (IVN) and superior (SVN) vestibular nerve. The EMG signals of the SCM were recorded. These recordings were compared to air- and bone-conduction evoked VEMPs with respect to latency and shape.
All subjects showed normal VEMPs upon acoustic stimulation with a latency of 12.8 +/- 1.4 ms for P13, and 22.7 +/- 2.0 ms for the N23 pre-operatively. Upon direct electrical Stimulation of the IVN, the mean latency of the positive peak was 9.1 +/- 2.2 and 13.2 +/- 2.3 ms for the negative one. No contralateral SCM response was found. Electrical stimulation of the SVN did not result in any EMG response of the SCM.
The study shows experimental evidence of the vestibulocollic reflex by direct electrical stimulation of the human IVN for the first time. The method can be utilized to map VIIIth nerve Subdivisions and to intraoperatively monitor IVN integrity in a real-time mode. (c) 2005 Elsevier B.V. All rights reserved.
C1 Hosp Univ Berlin, Charite Med Sch, Dept Otolaryngol, D-12683 Berlin, Germany.
Hosp Univ Berlin, Charite, Dept Microsurg, D-12683 Berlin, Germany.
RP Ernst, A (reprint author), Hosp Univ Berlin, Charite Med Sch, Dept Otolaryngol, Warener Str 7, D-12683 Berlin, Germany.
EM basta@rz.uni-potsdam.de; ArneborgE@ukb.de
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NR 29
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 111
EP 114
DI 10.1016/j.heares.2005.01.006
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200010
PM 15925196
ER
PT J
AU Wallace, MN
Shackleton, TM
Anderson, LA
Palmer, AR
AF Wallace, MN
Shackleton, TM
Anderson, LA
Palmer, AR
TI Representation of the purr call in the guinea pig primary auditory
cortex
SO HEARING RESEARCH
LA English
DT Article
DE phase-locking; vocalization; cortical column; communication
ID ALARM CALLS; VOCALIZATIONS; RESPONSES; MARMOSET; NEURONS; ORGANIZATION;
STIMULI; SOUNDS; AREAS; CAT
AB Guinea pigs produce the low-frequency purr or rumble call as all alerting signal. A digitised example of the call was presented to anaesthetised guinea pigs via a closed sound system while recording from the primary auditory cortex. The exemplar used ill this study had 9 regular phrases each spaced with their centres about 80 ins apart. Low-frequency ( <= 1.1 kHz) units responded best to the call but within this population there were four separate groups: (1) cells that responded vigorously to many or all of the 9 phrases;, (2) cells that gave an onset response;, (3) cells that only responded to a click embedded in the call; (4) cells that did not respond. Particular response types were often grouped together. Thus when orthogonal electrode tracks were used most units gave a similar response. There was no correlation between the type of response and the cortical depth. A similar range of response types was also found in the thalamus and there was no evidence of a distinct response in the cortex that was due to intracortical processing. Cells in the cortex were able to represent the temporal structure Of the purr With the same fidelity Lis cells in the thalamus. (c) 2005 Elsevier B.V. All rights reserved.
C1 MRC, Inst Hearing Res, Nottingham NG7 2RD, England.
RP Wallace, MN (reprint author), MRC, Inst Hearing Res, Univ Pk, Nottingham NG7 2RD, England.
EM markw@ihr.mrc.ac.uk
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NR 34
TC 23
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 115
EP 126
DI 10.1016/j.heares.2005.01.007
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200011
PM 15925197
ER
PT J
AU So, HS
Park, C
Kim, HJ
Lee, JH
Park, SY
Lee, JH
Lee, ZW
Kim, HM
Kalinec, F
Lim, DJ
Park, R
AF So, HS
Park, C
Kim, HJ
Lee, JH
Park, SY
Lee, JH
Lee, ZW
Kim, HM
Kalinec, F
Lim, DJ
Park, R
TI Protective effect of T-type calcium channel blocker flunarizine on
cisplatin-induced death of auditory cells
SO HEARING RESEARCH
LA English
DT Article
DE cisplatin; ototoxicity; flunarizine; organ of Corti
ID OUTER HAIR-CELLS; GUINEA-PIG; IN-VITRO; ANTAGONIST FLUNARIZINE;
ORGANOTYPIC CULTURES; INDUCED OTOTOXICITY; LIPID-PEROXIDATION; INDUCED
APOPTOSIS; INDUCED DAMAGE; NEURONS
AB Changes in intracellular Ca2+ level are involved in a number of intracellular events, including triggering of apoptosis. The role of intracellular calcium mobilization in cisplatin-induced hair cell death, however, is still unknown. In this study, the effect of calcium channel blocker flunarizine (Sibelium (TM)), Which is used to prescribe for vertigo and tinnitus, on cisplatin-induced hair cell death was investigated in a cochlear organ of Corti-derived cell line, HEI-OCI, and the neonatal (P2) rat organ of Corti explant. Cisplatin induced apoptotic cell death showing nuclear fragmentation, DNA ladder, and TUNEL positive in both HEI-OCI and primary organ of Corti explant. Flunarizine significantly inhibited the cisplatin-induced apoptosis. Unexpectedly, flunarizine increased the intracellular calcium ([Ca2+](i)) levels of HEI-OCI. However, the protective effect of flunarizine against cisplatin was not mediated by modulation of intracellular calcium level. Treatment of cisplatin resulted in ROS generation and lipid peroxidation in HEI-OCI. Flunarizine did not attenuate ROS production but inhibited lipid peroxidation and mitochondrial permeability transition in cisplatin-treated cells. This result suggests that the protective mechanism of flunarizine on cisplatin-induced cytotoxicity is associated with direct inhibition of lipid peroxidation and mitochondrial permeability transition. (c) 2005 Elsevier B.V. All rights reserved.
C1 Korea Basic Sci Inst, Vestibulocochlear Res Ctr, Taejon 305333, South Korea.
Korea Basic Sci Inst, Dept Microbiol, Taejon 305333, South Korea.
Korea Basic Sci Inst, Biomol Res Team, Taejon 305333, South Korea.
Kyung Hee Univ, Coll Oriental Med, Dept Pharmacol, Seoul, South Korea.
House Ear Res Inst, Gonda Dept Cell & Mol Biol, Los Angeles, CA 90057 USA.
RP Park, R (reprint author), Wonkwang Univ, Sch Med, Dept Microbiol, 344-7 Shinyong Dong, Iksan 570749, Jeonbuk, South Korea.
EM rkpark@wonkwang.ac.ar
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NR 53
TC 38
Z9 43
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 127
EP 139
DI 10.1016/j.heares.2005.01.011
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200012
PM 15925198
ER
PT J
AU Sone, M
Hayashi, H
Yamamoto, H
Hoshino, T
Mizushima, T
Nakashima, T
AF Sone, M
Hayashi, H
Yamamoto, H
Hoshino, T
Mizushima, T
Nakashima, T
TI Upregulation of HSP by geranylgeranylacetone protects the cochlear
lateral wall from endotoxin-induced inflammation
SO HEARING RESEARCH
LA English
DT Article
DE GGA; HSP; inner ear; otitis media; cochlear trauma
ID RAT COCHLEA; MOLECULAR CHAPERONES; OTITIS-MEDIA; NITRIC-OXIDE;
HEAT-SHOCK-PROTEIN-70; EXPRESSION; INDUCTION; STRESS; INJURY;
HYPERTHERMIA
AB We investigated whether an acyclic polyisoprenoid antiulcer drug, geranylgeranylacetone (GGA), induces the expression of HSP70 in the rat cochlea. Immunoblotting revealed upregulation of HSP70 in the cochlea at 12 h after transtympanic (local) or oral (systemic) administration of GGA, and this increased at 24 It after administration. Positive immunohistochemical staining of HSP70 was observed in the hair cells, the spiral ganglion, the stria vascularis, the spiral ligament, and the perivascular portion of modiolar vessels. We therefore subsequently studied the effects of GGA as an HSP-inducer on inner ear trauma due to inflammation. Damage to the lateral wall due to inflammation induced by lipopolysaccharide inoculation was protected against by pretreatment with GGA, as assessed physiologically by measurement of cochlear blood flow and morphologically by electron microscopy. The results of the present study suggest that GGA can protect the cochlea against other injuries including those induced by noise, ototoxic drugs, and ischemia by upregulating HSP70. (c) 2005 Elsevier B.V. All rights reserved.
C1 Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Showa Ku, Nagoya, Aichi 4668550, Japan.
Kumamoto Univ, Grad Sch Med & Pharmaceut Sci, Dept Microbiol, Kumamoto, Japan.
RP Sone, M (reprint author), Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Showa Ku, 65 Tsursmai Cho, Nagoya, Aichi 4668550, Japan.
EM michsone@med.nagoya-u.ac.jp
RI Nakashima, Tsutomu/B-8259-2012
OI Nakashima, Tsutomu/0000-0003-3930-9120
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NR 26
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 140
EP 146
DI 10.1016/j.heares.2005.01.012
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200013
PM 15925199
ER
PT J
AU Mulders, WHAM
Robertson, D
AF Mulders, WHAM
Robertson, D
TI Noradrenergic modulation of brainstem nuclei alters cochlear neural
output
SO HEARING RESEARCH
LA English
DT Article
DE noradrenaline; superior olivary complex; hearing; olivocochlear
efferents; guinea pig
ID AUDITORY-NERVE FIBERS; CROSSED OLIVOCOCHLEAR BUNDLE; GUINEA-PIG COCHLEA;
TEMPORARY THRESHOLD SHIFTS; SUPERIOR OLIVARY COMPLEX;
ELECTRICAL-STIMULATION; INFERIOR COLLICULUS; ROUND-WINDOW; OTOACOUSTIC
EMISSIONS; EFFERENT STIMULATION
AB The peripheral auditory sense organ, the cochlea, receives innervation from lateral and medial olivocochlear neurons in the brainstem. These neurons are able to modulate cochlear neural output. Anatomical studies have shown that one of the neurotransmitters which is present in varicosities surrounding the olivocochlear neurons in the brainstem is noradrenaline and previous work on brainstem slices has demonstrated a generally excitatory effect of noradrenaline on medial olivococlilear neurons. In order to assess in vivo the function of the noradrenergic inputs to olivocochlear neurons, we injected noradrenaline in the brainstem of anaesthetised guinea pigs and recorded ipsilateral cochlear electrical activity. Injections of noradrenaline close to the lateral olivocochlear neurons evoked increases in the sound-driven neural activity from the cochlea, measured as Compound action potential (CAP) amplitude, as well as in the spontaneous activity, measured as amplitude of the 900 Hz peak of the spectrum of the neural noise in the cochlear fluids. In contrast, noradrenaline in the vicinity of the medial olivocochlear neurons evoked inhibitory effects on both the CAP amplitude and 900 Hz peak. These results indicate most likely an excitatory action of noradrenaline on both the lateral and medial olivocochlear neurons in the brainstem. and show that such noradrenergic inputs can modulate cochlear function. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Western Australia, Sch Biomed & Chem Sci, Auditory Lab, Discipline Physiol, Perth, WA 6009, Australia.
RP Mulders, WHAM (reprint author), Univ Western Australia, Sch Biomed & Chem Sci, Auditory Lab, Discipline Physiol, Perth, WA 6009, Australia.
EM hmulders@cyllene.uwa.edu.au
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NR 54
TC 8
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 147
EP 155
DI 10.1016/j.heares.2005.01.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200014
PM 15925200
ER
PT J
AU Myrdal, SE
Johnson, KC
Steyger, PS
AF Myrdal, SE
Johnson, KC
Steyger, PS
TI Cytoplasmic and intra-nuclear binding of gentamicin does not require
endocytosis
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 27th Midwinter Research Meeting of the
Association-for-Research-in-Otolaryngology
CY FEB, 2004
CL Daytona Beach, FL
SP Assoc Res Otolaryngol
DE gentamicin; aminoglycoside; non-endocytotic; cytoplasmic; drug uptake
ID PREMATURE STOP MUTATIONS; SACCULAR HAIR-CELLS; PIG INNER-EAR;
AMINOGLYCOSIDE ANTIBIOTICS; GUINEA-PIG; LLC-PK1 CELLS; GOLGI-COMPLEX;
INDUCED NEPHROTOXICITY; TRANSDUCTION CHANNEL; PROXIMAL TUBULE
AB Understanding the cellular mechanism(s) by which the oto- and nephrotoxic aminoglycoside antibiotics penetrate cells, and the precise intracellular distribution of these molecules, will enable identification of aminoglycoside-sensitive targets, and potential uptake blockers. Clones of two kidney cell lines, OK and MDCK, were treated with the aminoglycoside gentamicin linked to the fluorophore Texas Red (GTTR). As in earlier reports, endosomal accumulation was observed in live cells, or cells fixed with formaldehyde only. However, delipidation of fixed cells revealed GTTR fluorescence in cytoplasmic and nuclear compartments. Immunolabeling of both GTTR and unconjugated gentamicin corresponded to the cytoplasmic distribution of GTTR fluorescence. Intra-nuclear GTTR binding co-localized with labeled RNA in the nucleoli and trans-nuclear tubules. Cytoplasmic and nuclear distribution of GTTR was quenched by phosphatidylinositol-bisphosphate (PIP2), a known ligand for gentamicin. Cytoplasmic and nuclear GTTR binding increased over time (at 37 degrees C, or on ice to inhibit endocytosis), and was serially competed off by increasing concentrations of unconjugated gentamicin, i.e., GTTR binding is saturable. In contrast, little or no reduction of endocytotic GTTR uptake was observed when cells were co-incubated with up to 4mg/mL unconjugated gentamicin. Thus, cytoplasmic and nuclear GTTR uptake is time-dependent, weakly temperature-dependent and saturable, suggesting that it occurs via an endosome-independent mechanism, implicating ion channels, transporters or pores in the plasma membrane as bioregulatory routes for gentamicin entry into cells. (c) 2005 Elsevier B.V. All rights reserved.
C1 Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
RP Steyger, PS (reprint author), Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM steygerp@ohsu.edu
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NR 75
TC 49
Z9 49
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 156
EP 169
DI 10.1016/j.heares.2005.02.002
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200015
PM 15925201
ER
PT J
AU Myrdal, SE
Steyger, PS
AF Myrdal, SE
Steyger, PS
TI TRPV1 regulators mediate gentamicin penetration of cultured kidney cells
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 27th Midwinter Research Meeting of the
Association-for-Research-in-Otolaryngology
CY FEB, 2004
CL Daytona Beach, FL
SP Assoc Res Otolaryngol
DE aminoglycosides; cytoplasmic drug uptake; non-endocytotic uptake; TRP
channel
ID VANILLOID RECEPTOR VR1; SACCULAR HAIR-CELLS; CAPSAICIN RECEPTOR; CATION
CHANNEL; FUNCTIONAL-CHARACTERIZATION; AMINOGLYCOSIDE ANTIBIOTICS;
NOCICEPTIVE NEURONS; GANGLIA NEURONS; FREEZE-FRACTURE; ION-CHANNEL
AB Transient receptor potential (TRP) receptors are, typically, calcium-permeant cation channels that transduce environmental stimuli. Both kidney epithelial and inner ear sensory cells express TRPV1, are mechanosensors and accumulate the aminoglycoside antibiotic gentamicin. Recently, we showed that Texas Red-conjugated gentamicin (GTTR) enters kidney cells via an endosome-independent pathway. Here, we used GTTR to investigate this non-endocytotic mechanism of gentamicin uptake. In serum-free buffers, GTTR penetrated MDCK cells within 30 s and uptake was modulated by extracellular, multivalent cations (Ca2+, La3+, Gd3+) or protons. We verified the La3+ modulation of GTTR uptake using immunocytochemical detection of unconjugated gentamicin. Membrane depolarization, induced by high extracellular K+ or valinomycin, also reduced GTTR uptake, suggesting electrophoretic permeation through ion channels.
GTTR uptake was enhanced by the TRPV1 agonists, resiniferatoxin and anandamide, in Ca2+-free media. Competitive antagonists of the TRPV1 cation current, iodo-resiniferatoxin and SB366791, also enhanced GTTR uptake independently of Ca2+ reinforcing these antagonists' potential as latent agonists in specific Situations. Ruthenium Red blocked GTTR uptake in the presence or absence of these TRPV1-agonists and antagonists. In addition, GTTR uptake was blocked by RTX in the presence of more physiological levels (2 mM) of Ca2+. Thus gentamicin enters cells via cation channels, and gentamicin uptake can be modulated by regulators of the TRPVI channel. (c) 2005 Elsevier B.V. All rights reserved.
C1 Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
RP Steyger, PS (reprint author), Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM steygerp@ohsu.edu
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NR 90
TC 51
Z9 53
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 170
EP 182
DI 10.1016/j.heares.2005.02.005
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200016
PM 15925202
ER
PT J
AU Gross, J
Machulik, A
Amarjargal, N
Fuchs, J
Mazurek, B
AF Gross, J
Machulik, A
Amarjargal, N
Fuchs, J
Mazurek, B
TI Expression of prestin mRNA in the organotypic culture of rat cochlea
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; hypoxia; ischemia; prestin mRNA
ID OUTER HAIR-CELLS; POLYMERASE CHAIN-REACTION; LOUD SOUND EXPOSURE; MOTOR
PROTEIN; GUINEA-PIG; POSTNATAL-DEVELOPMENT; ACOUSTIC EXPOSURE;
GENE-EXPRESSION; BLOOD-FLOW; RT-PCR
AB To quantitate in absolute terms the prestin mRNA levels in the explant Culture Of rat cochlea, we used competitive RT-PCR with a synthetic internal cRNA standard. Prestin gene expression was found at levels of 100 fg specific mRNA/Pg total RNA oil postnatal day 3, which corresponds to about 300 copies per outer hair cell (OHC) and is indicative of an intermediate level of expression. Two days of culturing resulted in ail increase of prestin mRNA levels and in the formation of an apical-basal gradient (p < 0.001). To elucidate the variations the prestin mRNA levels undergo as a result of damage to the organ of Corti, we exposed the explant cultures to ischemia and hypoxia. While total RNA was observed to remain unchanged, the numbers of OHCs and the prestin mRNA levels were found to decrease by about 20% and 35%, respectively, compared to normoxia.
In conclusion, we showed that the prestin mRNA levels during in vitro development increase and form an apical-basal gradient within 2 days in culture, similar to the postnatal in vivo development. Hypoxia and ischemia result in a decrease of the prestin mRNA level ill parallel with OHC loss. The prestin mRNA level call therefore be used as marker of damage to or loss of OHCs. (c) 2005 Elsevier B.V. All rights reserved.
C1 Humboldt Univ, Charite Hosp, Dept Otorhinolaryngol, Mol Biol Res Lab, D-14050 Berlin, Germany.
Hlth Sci Univ, Dept Hearing Res, Pediat Clin, Matern & Child Hlth Res Ctr, Ulaanbaatar, Mongol Peo Rep.
RP Gross, J (reprint author), Humboldt Univ, Charite Hosp, Dept Otorhinolaryngol, Mol Biol Res Lab, Spandauer Damm 130, D-14050 Berlin, Germany.
EM johann.gross@charite.de
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NR 30
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 183
EP 190
DI 10.1016/j.heares.2005.02.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200017
PM 15925203
ER
PT J
AU Supin, AY
Popov, VV
Milekhina, ON
Tarakanov, MB
AF Supin, AY
Popov, VV
Milekhina, ON
Tarakanov, MB
TI Rippled-spectrum resolution dependence on masker-to-probe ratio
SO HEARING RESEARCH
LA English
DT Article
DE spectrum-pattern resolution; rippled noise; dependence on level;
masking; humans
ID AUDITORY-NERVE FIBERS; 2-TONE SUPPRESSION; SIMULTANEOUS MASKING;
BASILAR-MEMBRANE; FILTER SHAPES; TUNING CURVES; FREQUENCY-SELECTIVITY;
DENSITY RESOLUTION; RESOLVING POWER; NOTCHED-NOISE
AB Resolution of rippled sound spectrum (probe) in the presence of additional noise band (masker) was studied as a function of rnasker-to-probe ratio and Sound level in normal listeners. The probe bands were 0.5-oct wide (ERB) centered at 2 kHz; the masker band either coincided with the probe (on-frequency masker), or was 3/4 octaves below (low-frequency masker), or 3/4 octaves above the probe (high-frequency masker). Ripple-density resolution in the probe band was measured by finding the highest ripple density at which an interchange of ripple peaks and valleys was detectable (the phase-reversal test). (i) The effect of the low-frequency masker increased (resolution decreased) when masker-to-probe ratio changed from -25 dB to +20 dB; the effect increased (resolution decreased) with sound level increase. (ii) The effect of the on-frequency masker steeply increased (resolution abruptly decreased) when masker-to-probe ratio exceeded 0 dB; the effect was little dependent on Sound level. (iii) The high-frequency masker was little effective unless the masker-to-probe ratio reached 30-40 dB; the effect increased (resolution decreased) with sound level decrease. Thus, different position of the masker band relative to the probe resulted in qualitatively different kinds of spectrum-pattern resolution dependence on both the masker-to-probe ratio and sound level. (c) 2005 Elsevier B.V. All rights reserved.
C1 Russian Acad Sci, Inst Ecol & Evolut, Moscow 117071, Russia.
RP Supin, AY (reprint author), Russian Acad Sci, Inst Ecol & Evolut, 33 Leninsky Prosp, Moscow 117071, Russia.
EM alex_supin@sevin.ru
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NR 46
TC 1
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 191
EP 199
DI 10.1016/j.heares.2005.01.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200018
PM 15925204
ER
PT J
AU Andrianov, GN
Puyal, J
Raymond, J
Venteo, S
Dememes, D
Ryzhova, IV
AF Andrianov, GN
Puyal, J
Raymond, J
Venteo, S
Dememes, D
Ryzhova, IV
TI Immunocytochemical and pharmacological characterization of metabotropic
glutamate receptors of the vestibular end organs in the frog
SO HEARING RESEARCH
LA English
DT Article
DE metabotropic receptors; neuromodulation; afferent synapse; semicircular
canal; frog
ID GROUP-I; SYNAPTIC-TRANSMISSION; SEMICIRCULAR CANALS; GANGLION NEURONS;
NMDA RECEPTORS; HAIR-CELLS; AGONISTS; RELEASE; MGLUR2; LOCALIZATION
AB Using immunocytochemistry and multiunit recording of afferent activity of the whole vestibular nerve, we investigated the role of metabotropic glutamate receptors (mGluR) in the afferent neurotransmission in the frog semicircular canals (SCC). Group I (rnGluR1 alpha) and group II (mGluR2/3) mGluR immunoreactivitics were distributed to the vestibular ganglion neurons, and this can be attributed to a postsynaptic locus of metabotropic regulation of rapid excitatory transmission. The effects of group I/II mGluR agonist (IS,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (ACPD) and antagonist (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) on resting and chemically induced afferent activity were studied. ACPD (10-100 mu M) enhanced the resting discharge frequency. MCPG (5-100 mu M) led to a concentration-dependent decrease of both resting activity and ACPD-induced responses. If the discharge frequency had previously been restored by L-glutainate (L-Glu) in high-Mg2+ solution, ACPD elicited a transient increase in the firing rate in the afferent nerve suggesting that ACPD acts on postsynaptic receptors. The L-Glu agonists, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) and N-methyl-D-aspartate (NMDA), were tested during application of ACPD. AMPA and NMDA-induced responses were higher in the presence than absence of ACPD. implicating mGluR in the modulation of ionotropic glutamate receptors. These results indicate that activation of mGluR potentiates AMPA and NMDA responses through a postsynaptic interaction. We conclude that ACPD may exert modulating postsynaptic effects on vestibular afferents and that this process is activity-dependent. (c) 2005 Elsevier B.V. All rights reserved.
C1 Russian Acad Sci, Lab Physiol Recept, IP Pavlov Physiol Inst, St Petersburg 199034, Russia.
Univ Lausanne, Dept Cell Biol & Morphol, CH-1005 Lausanne, Switzerland.
Univ Montpellier 2, F-34095 Montpellier, France.
Hop St Eloi, INSERM U583, INM, F-34295 Montpellier, France.
RP Andrianov, GN (reprint author), Russian Acad Sci, Lab Physiol Recept, IP Pavlov Physiol Inst, Nab Makarova 6, St Petersburg 199034, Russia.
EM andryu@infran.ru
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NR 37
TC 4
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 200
EP 209
DI 10.1016/j.heares.2005.02.003
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200019
PM 15925205
ER
PT J
AU Fujimoto, K
Nakagawa, S
Tonoike, M
AF Fujimoto, K
Nakagawa, S
Tonoike, M
TI Nonlinear explanation for bone-conducted ultrasonic hearing
SO HEARING RESEARCH
LA English
DT Article
DE ultrasonic hearings; bone conduction; pitch perception; amplitude
modulation; nonlinearity
ID FREQUENCY DISCRIMINATION; AUDITORY-CORTEX; PERCEPTION
AB Human listeners can perceive speech from a voice-modulated ultrasonic carrier presented via a bone-conduction stimulator. This study explored the psychoacoustic characteristics and underlying mechanisms of ultrasonic hearing by measuring difference limens for frequency (DLF) for pure tones modulated onto ultrasonic carriers. Human subjects were presented with two pulsed tones and asked to judge whether the first or the second had the higher pitch. When amplitude modulation was based on a double side-band trans-milled carrier, the DLFs were as small as those from the air-conducted pure tones at 0.25-4 kHz. Ultrasounds yielded larger DLFs for tones with low (0.125 kHz) and high (6-8 kHz) frequencies. Results were essentially identical between the two types of carriers, sine wave (30 kHz) and bandpass noise (30 +/- 4 kHz), despite the different bandwidths in the ultrasonic range. When amplitude modulation was based on a double side-band Suppressed carrier, DLFs corresponded to those from tones with double frequencies. These results suggest nonlinear conduction that demodulates audible signals from ultrasounds and provides inputs to the cochlea. (c) 2005 Elsevier B.V. All rights reserved.
C1 Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
RP Fujimoto, K (reprint author), Kwansei Gakuin Univ, Sch Human, Dept Psychol, 1-1-155 Uegahara, Nishinomiya, Hyogo 6628501, Japan.
EM kys.fujitnoto@kwansei.ac.jp; s-nakagawa@aist.go.jp
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NR 17
TC 19
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 210
EP 215
DI 10.1016/j.heares.2005.02.004
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200020
PM 15925206
ER
PT J
AU Nagy, I
Bodmer, M
Schmid, S
Bodmer, D
AF Nagy, I
Bodmer, M
Schmid, S
Bodmer, D
TI Promyelocytic leukemia zinc finger protein localizes to the cochlear
outer hair cells and interacts with prestin, the outer hair cell motor
protein
SO HEARING RESEARCH
LA English
DT Article
DE organ of Corti; PLZF; prestin; yeast two-hybrid
ID MEMBRANE MOTOR; GENE-EXPRESSION; PLZF PROTEIN; REPRESSION; TENSION
AB Hair cells in the auditory sensory organ are specialized mechanoreceptors common to mammalian and non-mammalian species. The mammalian cochlear outer hair cells (OHC) possess a distinct motile property, dubbed membrane-based electromotility, that enhances the receptor function. This electromotility is believed to be the basis of cochlear amplification that increases sensitivity of the mammalian ear to sound. Prestin, a unique voltage-sensitive motor molecule localized in the lateral membrane of OHC, is presumably responsible for OHC electromotility. It has been documented that prestin null-animals lack electromotility and suffer from similar to 50 dB loss of hearing sensitivity. To identify proteins that interact with prestin we carried out a yeast two-hybrid library screen using the C-terminal intracellular domain of prestin as bait. Seven bait-dependent prey clones were identified independently. Further analysis revealed that they encode partially over-lapping regions of a single protein: a transcriptional repressor, promyleocytic leukemia zinc finger protein (PLZF). PLZF encodes a POZ/domain Kruppel-type zinc finger transcription factor reported to have pro-apoptotic and anti-proliferative activity. The interaction between endogenous prestin and PLZF proteins in the cochlea was confirmed by co-immunoprecipitation using organ of Corti lysates. Furthermore, immunohistochemical studies strongly suggest that PLZF co-localizes with prestin near the lateral membrane of cochlear OHC. The physiological significance of this interaction remains to be explored. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Zurich Hosp, ENT Dept, Inner Ear Res Lab, CH-8091 Zurich, Switzerland.
ETH, Zurich, Switzerland.
RP Bodmer, D (reprint author), Univ Zurich Hosp, ENT Dept, Inner Ear Res Lab, NORD 2 Frauenklin Str 24, CH-8091 Zurich, Switzerland.
EM Ivana.Nagy@usz.ch; daniel.bodiner@usz.ch
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NR 26
TC 8
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JUN
PY 2005
VL 204
IS 1-2
BP 216
EP 222
DI 10.1016/j.heares.2005.02.007
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 938HJ
UT WOS:000229990200021
PM 15925207
ER
PT J
AU Lee, HJ
Kang, E
Oh, SH
Kang, H
Lee, DS
Lee, MC
Kim, CS
AF Lee, HJ
Kang, E
Oh, SH
Kang, H
Lee, DS
Lee, MC
Kim, CS
TI Preoperative differences of cerebral metabolism relate to the outcome of
cochlear implants in congenitally deaf children
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implants; brain imaging; PET; deafness
ID POSITRON EMISSION TOMOGRAPHY; VERBAL WORKING-MEMORY; HUMAN
AUDITORY-CORTEX; SPEECH-PERCEPTION; CORTICAL ACTIVATION; PREFRONTAL
CORTEX; VISUAL-ATTENTION; NORMAL-HEARING; PET; PLASTICITY
AB In congenitally deaf children, chronological age is generally accepted as a critical factor that affects successful rehabilitation following cochlear implantation (0). However, a wide variance among patients is known to exist regardless of the age at CI [Sarant, J.Z., Blarney, P.J., Dowell, R.C., Clark, G.M., Gibson, W.P., 2001. Variation in speech perception scores among children with cochlear implants. Ear Hear. 22, 18-28]. In a previous study, we reported that prelingually deaf children in the age range 5-7 years at implantation showed greatest outcome variability [Oh S.H., Kim C.S., Kang E.J., Lee D.S., Lee H.J., Chang S.O., Ahn S.H., Hwang C.H., Park H.J., Koo J.W., 2003. Speech perception after cochlear implantation over a 4-year time period. Acta Otolaryngol. 123, 148-153]. Eleven children who underwent CI between the age of 5 and 7 1/2 years were subdivided into a good (above 65%: GOOD) and a poor (below 45%: POOR) group based on the performance in a speech perception test given 2 years after CI. The preoperative F-18-FDG-PET (F-18 fluorodeoxyglucose positron emission tomography) images were compared between the two groups in order to examine if regional glucose metabolic difference preexisted before the CI surgery. In the GOOD group, metabolic activity was greater in diverse fronto-parietal regions compared to the POOR group. In the POOR group, the regions related to the ventral visual pathway showed greater metabolic activity relative to the GOOD group. These findings suggest that the deaf children who had developed greater executive and visuospatial functions subserved by the prefrontal and parietal cortices might be successful in auditory language learning after CI. On the contrary, greater dependency on the visual function subserved by the occipito-temporal region due to auditory deprivation may interfere with acquisition of auditory language after CI. (c) 2004 Elsevier B.V. All rights reserved.
C1 Seoul Natl Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
Seoul Natl Univ, Coll Med, Dept Nucl Med, Seoul 110744, South Korea.
RP Oh, SH (reprint author), Seoul Natl Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
EM shaoh@snu.ac.kr
RI Lee, Dong Soo/J-2778-2012; Oh, Seung Ha/J-5540-2012
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NR 46
TC 29
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 2
EP 9
DI 10.1016/j.heares.2004.11.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300001
PM 15855024
ER
PT J
AU Pandya, PK
Moucha, R
Engineer, ND
Rathbun, DL
Vazquez, J
Kilgard, MP
AF Pandya, PK
Moucha, R
Engineer, ND
Rathbun, DL
Vazquez, J
Kilgard, MP
TI Asynchronous inputs alter excitability, spike timing, and topography in
primary auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE cortical plasticity; map reorganization; activity-dependent hebbian
plasticity; sensory input; rat; auditory cortex; nucleus basalis
ID ADULT OWL MONKEYS; TEMPORAL RESPONSE PROPERTIES; BASAL FOREBRAIN;
SYNAPTIC MODIFICATION; CORTICAL PLASTICITY; NUCLEUS BASALIS; CONVERGENT
STRABISMUS; SOMATOSENSORY CORTEX; PHYSIOLOGICAL MEMORY; DISCRIMINATION
TASK
AB Correlation-based synaptic plasticity provides a potential cellular mechanism for learning and memory. Studies in the visual and somatosensory systems have shown that behavioral and surgical manipulation of sensory inputs leads to changes in cortical organization that are consistent with the operation of these learning rules. In this study, we examine how the organization of primary auditory cortex (A1I) is altered by tones designed to decrease the average input correlation across the frequency map. After one month of separately pairing nucleus basalis stimulation with 2 and 14 kHz tones, a greater proportion of A1 neurons responded to frequencies below 2 kHz and above 14 kHz. Despite the expanded representation of these tones, cortical excitability was specifically reduced in the high and low frequency regions of A1, as evidenced by increased neural thresholds and decreased response strength. In contrast, in the frequency region between the two paired tones, driven rates were unaffected and spontaneous firing rate was increased. Neural response latencies were increased across the frequency map when nucleus basalis stimulation was associated with asynchronous activation of the high and low frequency regions of A1. This set of changes did not occur when pulsed noise bursts were paired with nucleus basalis stimulation. These results are consistent with earlier observations that sensory input statistics can shape cortical map organization and spike timing. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Texas, Program Neurosci, Sch Behav & Brain Sci, Richardson, TX 75083 USA.
RP Pandya, PK (reprint author), Univ Texas, Program Neurosci, Sch Behav & Brain Sci, POB 830688,GR 41, Richardson, TX 75083 USA.
EM pritesh@utdallas.edu
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NR 51
TC 13
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 10
EP 20
DI 10.1016/j.heares.2004.11.018
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300002
PM 15855025
ER
PT J
AU Caye-Thomasen, P
Wagner, N
Frederiksen, BL
Asal, K
Thomsen, J
AF Caye-Thomasen, P
Wagner, N
Frederiksen, BL
Asal, K
Thomsen, J
TI Erythropoietin and erythropoietin receptor expression in the guinea pig
inner ear
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; spiral ganglion neurons; Deiters' cells; fibrocytes; phalangeal
cells; EPO; EPO receptor
ID CENTRAL-NERVOUS-SYSTEM; PLEIOTROPIC FUNCTIONS; IN-VITRO; BRAIN;
NEUROPROTECTION; NEURONS; CELLS; LOCALIZATION; ISCHEMIA; PROTECTS
AB The erythropoietin receptor (EPOR) is expressed in the brain and erythropoietin (EPO) has been shown to have neurotrophic and neuroprotective functions in the central nervous system and in the retina. These findings may be applied to the inner ear, pending EPO receptor presence. Accordingly, this study determines expression of EPO and EPOR in the inner ear of the guinea pig. Normal guinea pig inner ears were processed for immunohistochemistry, using poly-clonal antibodies against EPO and the EPO receptor. EPO expression was exclusively found in most, but not all spiral ganglion neurons. Expression of the EPO receptor was found in the cytoplasm of the inner and outer phalangeal cells (Deiters' cells), as well as the inner sulcus cells and the supporting cells of the organ of Corti (Hensen, Claudius and some Boettcher cells). Some spiral ganglion neurons or glial cells expressed the receptor, as did spiral ligament fibrocytes, some intermediate cells of stria vascularis and the endothelial cells of some modiolar vessels. No parts of the vestibular system stained positive for either antibody. We conclude, that EPO is expressed by spiral ganglion neurons and that the EPO receptor is widely expressed by several cell types within the guinea pig cochlea. We hypothesize on the existence of a local paracrine system and that EPO treatment may be feasible following inner ear damage. (c) 2004 Published by Elsevier B.V.
C1 Gentofte Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, DK-2900 Hellerup, Denmark.
RP Caye-Thomasen, P (reprint author), Gentofte Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, DK-2900 Hellerup, Denmark.
EM peca@gentoftehosp.kbhamt.dk
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NR 32
TC 16
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 21
EP 27
DI 10.1016/j.heares.2004.11.017
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300003
PM 15855026
ER
PT J
AU Kulahli, I
Balci, K
Koseoglu, E
Yuce, L
Cagli, S
Senturk, M
AF Kulahli, I
Balci, K
Koseoglu, E
Yuce, L
Cagli, S
Senturk, M
TI Audio-vestibular disturbances in Behcet's patients: report of 62 cases
SO HEARING RESEARCH
LA English
DT Article
DE Behcet's syndrome; hearing loss; vestibular disturbance;
audio-vestibular test; HLA-B51
ID DISEASE; INVOLVEMENT; HEARING
AB This study was carried out to determine the characteristics and incidence of hearing loss and vestibular disturbance in Behcet's syndrome with a large number of patients.
Sixty-two patients with Behcet's syndrome were included in this study, 34 men and 28 women whose mean age was 33.7 (15-60). Sixty-two healthy normal control subjects (38 male and 24 female) were included. Patient and control groups were questioned about any history of audio-vestibular disturbance and underwent physical and ENT examination and the following audiologic tests: pure tone audiometric test (0.25, 0.5, 1, 2, 4, and 6 kHz), tympanogram, speech discrimination, short increment sensitivity index, tone-decay test, auditory brainstem response. Vestibular system was evaluated by videonistagmogram and caloric test. Cranial and brainstem magnetic resonance imagine (MRI) of patients who have vestibular disturbances were practiced to examine the central nervous system. Both the patient and the control groups were tested with the HLA-B51 antigen.
Pure tone audiogram showed sensory-neural hearing loss (>= 25 dB hearing level in at least two frequencies) in 20 of the 62 (32%) Behcet's patients while the control group were normal. There was a hearing loss involving high frequencies in the audiograms of Belicet's patients with hearing disturbances. The recruitment investigation tests and auditory brain stem response confirmed cochlear involvement in all 20 patients. Caloric stimulation tests revealed a normal vestibular function in all patient and control group. In electronystagmography, 21 (34%) patients had hypometric or hypermetric saccades and smooth pursuit tests showing that 4 (6%) patients had pathological changes while the control group was normal. HLA-B51 antigen was found positive in 15 of 20 Belicet's patient with hearing loss.
Conclusion: (1) The hearing and vestibular disturbances in Behcet's syndrome is more prevalent than previously recognized; (2) Hearing loss in high frequencies in Behcet's patients is an indicator of cochlear involvement in this disease; (3) There is a higher prevalence of central vestibular syndrome in Belicet's patients than it was thought before; (4) HLA-B51 antigen may be able to be a prognostic factor for sensorineural hearing loss in Belicet's patients. (c) 2004 Elsevier B.V. All rights reserved.
C1 Talas Yolu Erciyes Univ Kulak Burun Bogaz, Erciyes Univ, Ear Nose Throat KBB, TR-38015 Kayseri, Turkey.
Yozgat Devlet Hastanesi, Yozgat, Turkey.
Talas Yolu Erciyes Univ, Erciyes Univ, Noro Ji ABD, TR-38015 Kayseri, Turkey.
Lokman Hekim Tip Merkezi, Kayseri, Turkey.
RP Yuce, L (reprint author), Talas Yolu Erciyes Univ Kulak Burun Bogaz, Erciyes Univ, Ear Nose Throat KBB, TR-38015 Kayseri, Turkey.
EM imdatyuce@hotmail.com
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NR 12
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 28
EP 31
DI 10.1016/j.heares.2004.11.020
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300004
PM 15855027
ER
PT J
AU Szalda, K
Burkard, R
AF Szalda, K
Burkard, R
TI The effects of nembutal anesthesia on the auditory steady-state response
(ASSR) from the inferior colliculus and auditory cortex of the
chinchilla
SO HEARING RESEARCH
LA English
DT Article
DE auditory steady-state response; difference tone; auditory evoked
potential; anesthesia; chinchilla; nembutal
ID MODULATION FOLLOWING RESPONSE; EVOKED-POTENTIALS; TONES; FREQUENCY;
SLEEP; HUMANS
AB We examined the effects of nembutal anesthesia on the amplitude of the auditory steady-state response (ASSR) in the inferior colliculus (IC) and auditory cortex (AC) of the chinchilla. Tungsten electrodes were chronically implanted following anesthesia with ketamine/acepromazine. After a recovery period, the chinchillas were placed in a passive restraining device and put in a sound-attenuating booth. Recordings were made from the right IC and AC simultaneously, while a two-tone stimulus was presented to the left ear. The stimuli consisted of two equal-level tones (F1 and F2) that were mixed acoustically; F1 remained constant at 2000 Hz, while F2 varied between 2029 and 2249 Hz, in steps of similar to 20 Hz. The Stimuli decreased in 10 dB steps from 80 to 30 dB pSPL. Animals were evaluated when unanesthetized, as well as when anesthetized with nembutal (on separate days).
In the IC, the administration of nembutal resulted in either no change in ASSR amplitude or an amplitude increase for difference tone (DT) frequencies below 90 Hz, while an amplitude decrease was typically seen for DT frequencies at or above 90 Hz. In the AC, a decrease in amplitude was seen across DT frequencies and stimulus levels after the administration of nembutal anesthesia. Our results suggest that both the AC and IC may contribute to the scalp-recorded ASSR in the awake state. However, in the nembutal -anesthetized state, it seems unlikely that the AC contributes substantially to the surface-recorded ASSR, as the AC response was greatly attenuated under nembutal anesthesia. In contrast, the IC ASSR responses remained robust, which makes it a likely contributor to the surface-recorded responses under nembutal anesthesia. (c) 2004 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Ctr Hearing & Deafness, Dept Communicat Disorders & Sci, Buffalo, NY 14214 USA.
SUNY Buffalo, Dept Otolaryngol, Buffalo, NY 14214 USA.
RP Szalda, K (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, Dept Communicat Disorders & Sci, 137 Cary Hall, Buffalo, NY 14214 USA.
EM kmszalda@acsu.buffalo.edu
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NR 27
TC 10
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 32
EP 44
DI 10.1016/j.heares.2004.11.014
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300005
PM 15855028
ER
PT J
AU Lukashkin, AN
Russell, IJ
AF Lukashkin, AN
Russell, IJ
TI Dependence of the DPOAE amplitude pattern on acoustical biasing of the
cochlear partition
SO HEARING RESEARCH
LA English
DT Article
DE otoacoustic emissions; cochlear mechanics; hair cell transducer
ID PRODUCT OTOACOUSTIC EMISSIONS; CELL MECHANOELECTRICAL TRANSDUCER;
GUINEA-PIG COCHLEA; HAIR-CELLS; DISTORTION PRODUCTS; LOW-LEVEL; 2F1-F2;
ORIGIN; PRIMARIES; RESPONSES
AB Distortion product otoacoustic emissions (DPOAEs) were recorded from guinea pigs in response to simultaneous increases in the levels of high frequency primary tones in the presence of a low frequency biasing tone of 30 Hz at 120 dB SPL. The DPOAE amplitudes plotted as functions of the biasing tone phase angle show distinctive repeatable minima, which are identical to the amplitude notches observed for the distortion products at the output of a single saturating non-linearity. The number of the amplitude minima grows with increasing order of the DPOAE, a feature that is also reproduced by the model. The model of DPOAE generation due to a single saturating non-linearity does not explain the experimentally observed asymmetry of the response of the DPOAEs to rising and falling half cycles of the biasing tone. This asymmetry is attributed to a hypothetical mechanism, which adjusts the operating point of the outer hair cell's mechanoelectrical transducer. Experimental data were consistent with a hypothesis that, for the parameters of stimulation used in this study, both lower and upper sideband DPOAEs are dominated by emission generated from a single and spatially localized place in the cochlea. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Sussex, Sch Life Sci, Brighton BN1 9QG, E Sussex, England.
RP Lukashkin, AN (reprint author), Univ Sussex, Sch Life Sci, Brighton BN1 9QG, E Sussex, England.
EM a.lukashkin@sussex.ac.uk
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NR 30
TC 16
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 45
EP 53
DI 10.1016/j.heares.2004.11.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300006
PM 15855029
ER
PT J
AU Wardrop, P
Whinney, D
Rebscher, SJ
Roland, JT
Luxford, W
Leake, PA
AF Wardrop, P
Whinney, D
Rebscher, SJ
Roland, JT
Luxford, W
Leake, PA
TI A temporal bone study of insertion trauma and intracochlear position of
cochlear implant electrodes. 1: comparison of Nucleus banded and Nucleus
Contour (TM) electrodes
SO HEARING RESEARCH
LA English
DT Article
ID ELECTRICAL-STIMULATION; SPEECH-PERCEPTION; AUDITORY-NERVE; ARRAY;
HEARING; PATIENT; HISTOPATHOLOGY; CONFIGURATION; RECOGNITION; EXCITATION
AB In recent years, new designs of cochlear implant electrodes have been introduced in an attempt to improve efficiency and performance by locating stimulation sites closer to spiral ganglion neurons and deeper into the scala tympani. The goal of this study was to document insertion depth, intracochlear position and insertion trauma with the Nucleus Contour (TM) electrode and to compare results to those observed with the earlier generation Nucleus banded electrode.
For this comparison eight Nucleus banded electrodes and 18 Contour (TM) electrodes were implanted in cadaver temporal bones using a realistic surgical exposure. Two experienced cochlear implant surgeons and two otology fellows with specialized training in cochlear implant surgery were selected for the study to represent a range of surgical experience similar to that of surgeons currently performing the procedure throughout the world. Following insertion of the electrodes, specimens were imaged using plain film X-ray, embedded in acrylic resin, cut in radial sections with the electrodes in place, and each cut surface was polished. Insertion depth was measured in digitized X-ray images, and trauma was assessed in each cross-section.
The Contour (TM) electrode inserted more deeply (mean depth = 17.9 mm or 417 degrees) than the banded electrode (mean depth = 15.3 mm or 285 degrees). The incidence and severity of trauma varied Substantially among the temporal bones studied. However, the nature and frequency of injuries observed with the two devices were very similar. The Contour (TM) electrode was clearly positioned closer to the modiolus than the banded model, and also appeared easier to use. Based on this difference in position and data from previous studies we conclude that the Contour- electrode may provide lower thresholds and improved channel selectivity, but the incidence of trauma remains a problem with the newer design. The relative influences of electrode positioning and neural degeneration that may result from trauma are as yet unclear. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Calif San Francisco, Dept Otolaryngol, HNS, Epstein Lab, San Francisco, CA 94143 USA.
Crosshouse Hosp, Dept Otolaryngol, Kilmarnock KA2 0BE, Ayr, Scotland.
Royal Cornwall Hosp, Dept Otolaryngol, Truro TR1 3LJ, Cornwall, England.
NYU, Med Ctr, Dept Otol Neurotol, New York, NY 10016 USA.
House Ear Res Inst, Los Angeles, CA 90057 USA.
RP Rebscher, SJ (reprint author), Univ Calif San Francisco, Dept Otolaryngol, HNS, Epstein Lab, 533 Parnassus Ave,Room C401, San Francisco, CA 94143 USA.
EM peterwardrop@doctors.org.uk; reb@itsa.ucsf.edu; tom.roland@med.nyu.edu;
leake@itsa.ucsf.edu
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NR 48
TC 58
Z9 59
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 54
EP 67
DI 10.1016/j.heares.2004.11.006
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300007
PM 15855030
ER
PT J
AU Wardrop, P
Whinney, D
Rebscher, SJ
Luxford, W
Leake, P
AF Wardrop, P
Whinney, D
Rebscher, SJ
Luxford, W
Leake, P
TI A temporal bone study of insertion trauma and intracochlear position of
cochlear implant electrodes. II: Comparison of Spiral Clarion (TM) and
HiFocus II (TM) electrodes
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; insertion; trauma; electrodes
ID ELECTRICALLY STIMULATED COCHLEA; SCALA TYMPANI; AUDITORY-NERVE;
HISTOPATHOLOGY; SELECTIVITY; DIMENSIONS; PATTERNS; DEAFNESS; PATIENT;
ARRAY
AB In recent years, several new designs of cochlear implant electrodes have been introduced clinically with the goal of optimizing perimodiolar placement of stimulation sites. Previous studies suggest that perimodiolar electrodes may increase both the efficiency and performance of a cochlear implant. This is the second of two studies designed to examine the positioning of electrodes and the occurrence of insertion-related injury with these newer designs and to directly compare two perimodiolar electrodes to their predecessors. In our previous report we compared the Nucleus (TM) banded electrode with the Nucleus Contour (TM) perimodiolar electrode. In the present study, using the same protocol, we examine the Spiral Clarion (TM) electrode and its successor, the HiFocus II (TM) electrode with attached positioner.
Eight Spiral Clarion (TM) arrays and 20 HiFocus II (TM) electrodes with positioners were inserted into human cadaver temporal bones. Following insertion, the specimens were embedded in acrylic resin, cut in quarters with a diamond saw and polished. Insertion depth, proximity to the modiolus and trauma were evaluated in X-ray images and light microscopy.
The newer electrode was consistently positioned closer to the modiolus than the previous device whereas the angular depth of insertion measured for the two electrodes was similar. The incidence of trauma was minimal when either electrode was inserted to a depth of less than 400 degrees. However, severe trauma was observed in every case in which the HiFocus II (TM) with positioner was inserted beyond 400 degrees and in some cases in which the Spiral Clarion (TM) was inserted beyond 400 degrees. To evaluate the possible role of electrode size in the trauma observed we modeled both devices relative to the dimensions of the scala tympani. We found that the fully inserted HiFocus II (TM) electrode with positioner was larger than the scala tympani in approximately 70% of temporal bones measured. The results suggest that both the Clarion (TM) spiral and HiFocus II (TM) with positioner can be inserted with minimal trauma, but in many cases not to the maximum depth allowed by the design. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Calif San Francisco, Dept Otolaryngol, HNS, Epstein Lab, San Francisco, CA 94143 USA.
Crosshouse Hosp, Dept Otolaryngol, Kilmarnock KA2 0BE, Ayr, Scotland.
Royal Cornwall Hosp, Dept Otolaryngol, Truro TR1 3LJ, Cornwall, England.
House Ear Res Inst, Los Angeles, CA 90057 USA.
RP Rebscher, SJ (reprint author), Univ Calif San Francisco, Dept Otolaryngol, HNS, Epstein Lab, San Francisco, CA 94143 USA.
EM peterwardrop@doctors.org.uk; reb@itsa.ucsf.edu; leake@itsa.ucsf.edu
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NR 30
TC 47
Z9 48
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 68
EP 79
DI 10.1016/j.heares.2004.11.007
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300008
PM 15855031
ER
PT J
AU Cappaert, NLM
Klis, SFL
Wijbenga, J
Smoorenburg, GF
AF Cappaert, NLM
Klis, SFL
Wijbenga, J
Smoorenburg, GF
TI Acceleration of cisplatin ototoxicity by perilymphatic application of
4-methylthiobenzoic acid
SO HEARING RESEARCH
LA English
DT Article
DE cisplatin; 4-methylthiobenzoic acids sodium thiosulfate; compound action
potential; summating potential; guinea pig
ID ALBINO GUINEA-PIG; INDUCED HEARING-LOSS; STRIA VASCULARIS; D-METHIONINE;
SODIUM THIOSULFATE; COCHLEAR POTENTIALS; ROUND WINDOW;
ANTITUMOR-ACTIVITY; PROTECTIVE AGENTS; RECOVERY
AB The antitumor agent cisplatin has dose-limiting side effects such as ototoxicity. Systemical co-treatment with anti-oxidants like 4-methylthiobenzoic acid (MTBA) and sodium thiosulfate (STS) provides protection against cisplatin ototoxicity. However, systemically administered protective agents may reduce the chemotherapeutic effect of cisplatin. Local application of the protective agents could avoid this undesirable effect. In the present study, we aimed at suppressing cisplatin -induced ototoxicity in guinea pigs by administering MTBA or STS perilymphatically through cochlear perfusion. Guinea pig cochleas were perfused for 10 min with artificial perilymph (ArtP) containing cisplatin at 0.3 mg/ml, either alone, or in combination with MTBA (0. 1 or 1.0 mg/ml) or STS (0.75 or 3.0 mg/ml). The compound action potential (CAP) and the summating potential (SP), evoked by 8 kHz tone bursts, and the endocochlear potential (EP; MTBA only) were measured just before and 1, 2, 3 and 4 h after perfusion. Cisplatin gradually reduced the CAP amplitude in time. Adding MTBA only accelerated this ototoxic effect. After cisplatin treatment a decline was found in the EP, irrespective of co-treatment, i.e., addition of MTBA did not accelerate the EP decrease. In contrast to MTBA, STS ameliorated the ototoxic effect of cisplatin. In conclusion, focal application of anti-oxidants can ameliorate cisplatin ototoxicity but this is not a feature of all anti-oxidants. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Utrecht, Med Ctr, Dept Otorhinolaryngol, Hearing Res Labs, NL-3508 GA Utrecht, Netherlands.
RP Klis, SFL (reprint author), Univ Utrecht, Med Ctr, Dept Otorhinolaryngol, Hearing Res Labs, Room G02-531,POB 85-500, NL-3508 GA Utrecht, Netherlands.
EM s.klis@kmb.azu.nl
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NR 41
TC 2
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 80
EP 87
DI 10.1016/j.heares.2004.10.012
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300009
PM 15855032
ER
PT J
AU Kalay, E
Caylan, R
Kremer, H
de Brouwer, APM
Karaguzel, A
AF Kalay, E
Caylan, R
Kremer, H
de Brouwer, APM
Karaguzel, A
TI GJB2 mutations in Turkish patients with ARNSHL: prevalence and two novel
mutations
SO HEARING RESEARCH
LA English
DT Article
DE hearing loss; connexin 26; GJB2; GJB6; 35delG
ID NONSYNDROMIC HEARING-LOSS; SENSORINEURAL DEAFNESS; CHILDHOOD DEAFNESS;
CONNEXIN-26 MUTATIONS; PRELINGUAL DEAFNESS; MOLECULAR-BASIS;
GAP-JUNCTIONS; GENE; POPULATION; DFNB1
AB Mutations in the connexin 26 gene (GJB2) cause a significant proportion of prelingual non-syndromic autosomal recessive deafness in all populations studied so far. To determine the percentage of hearing loss attributed to GJB2 in northeast Turkey, 93 unrelated patients with autosomal recessive non-syndromic hearing loss (ARNSHL) were screened. Seven different mutations were found in 29 of the patients with severe to profound hearing loss. The 35delG mutation was the most common mutation, accounting for 76% of all mutant GJB2 alleles. Four already described mutations, W24X, 310del14, delE120 and R184P and two novel mutations, Q80K and P173S, were identified. The allelic Delta(GJB6-D13S1830), which can cause hearing loss in combination with GJB2 mutations, was not present in our patients. Our results are comparable to those reported in other regions in Turkey and indicate that GJB2 mutations account for about 30% of Turkish patients with ARNSHL. Besides 35delG, W24X and delE120 occur more than once in the Turkish ARNSHL population with a frequency of about 5%. (c) 2004 Elsevier B.V. All rights reserved.
C1 Radboud Univ, Nijmegen Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands.
Radboud Univ, Nijmegen Med Ctr, Dept Otorhinolaryngol, Nijmegen, Netherlands.
Karadeniz Tech Univ, Fac Med, Dept Otorhinolaryngol, Trabzon, Turkey.
Karadeniz Tech Univ, Fac Med, Dept Med Biol, Trabzon, Turkey.
RP Kalay, E (reprint author), Radboud Univ, Nijmegen Med Ctr, Dept Human Genet, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM e.kalay@antrg.umcn.nl
RI Kremer, Hannie/F-5126-2010
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2004, CONNEXIN DEAFNESS HO
NR 42
TC 32
Z9 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 88
EP 93
DI 10.1016/j.heares.2004.11.022
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300010
PM 15855033
ER
PT J
AU Chen, YS
Tseng, FY
Liu, TC
Lin-Shiau, SY
Hsu, CJ
AF Chen, YS
Tseng, FY
Liu, TC
Lin-Shiau, SY
Hsu, CJ
TI Involvement of nitric oxide generation in noise-induced temporary
threshold shift in guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE nitric oxide; noise; temporary threshold shift
ID COCHLEAR BLOOD-FLOW; NA+/K+-ATPASE ACTIVITY; INDUCED HEARING-LOSS;
LATERAL WALL; LOUD SOUND; REPERFUSION INJURY; ACOUSTIC TRAUMA;
SUPEROXIDE; APOPTOSIS; ISCHEMIA
AB The present study explored the role of endogenous nitric oxide (NO) in the temporary threshold shift caused by acoustic trauma. Guinea pigs were exposed to broadband white noise at a level of 105 +/- 2 dB sound pressure level (SPL) for 10 min, causing a temporary threshold shift (TTS). The guinea pigs were divided into six groups (N-1 to N-6) according to survival days after noise exposure (0, 1, 2, 3, 7, 28 days). Auditory brainstem responses (ABR) were recorded before noise exposure, immediately after noise exposure and before sacrifice. Immediately after animals were sacrificed, the stria vascularis and the spiral ligament of the lateral wall of each individual cochlea were harvest as a unit and prepared for assay of NO. There was a significant correlation (P < 0.001) between the NO concentration and final ABR threshold in the noise exposure groups. But the return of ABR threshold to pre-noise-exposed level is early than that of NO concentration.
An average 16.2 dB threshold shift was found immediately after noise exposure. The threshold returned to the pre-noise-exposed level on the second post-exposure day. Comparing to unexposed control animals, the NO concentration increased nearly threefold immediately following noise exposure and decreased to twofold when the hearing threshold had returned to the pre-noise-exposed level. On the seventh post-exposure day the NO concentration was not different from that in unexposed control animals.
Those findings indicate that endogenous NO is generated in the noise-induced temporal threshold shift and its concentration is correlated with the hearing loss. (c) 2005 Elsevier B.V. All rights reserved.
C1 Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan.
Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.
Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan.
RP Chen, YS (reprint author), Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan.
EM sos008@ha.mc.ntu.edu.tw; cjhsu@ha.mc.ntu.edu.tw
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NR 52
TC 18
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 94
EP 100
DI 10.1016/j.heares.2004.12.006
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300011
PM 15855034
ER
PT J
AU Kaiser, CL
Girod, DA
Durham, D
AF Kaiser, CL
Girod, DA
Durham, D
TI Breed-dependent susceptibility to acute sound exposure in young chickens
SO HEARING RESEARCH
LA English
DT Article
DE avian; auditory; sound damage; cochlea; basilar papilla
ID INDUCED HEARING-LOSS; HAIR CELL LOSS; INTENSE AUDITORY-STIMULATION;
NOISE-INDUCED APOPTOSIS; SEVERE ACOUSTIC TRAUMA; AVIAN INNER-EAR;
BASILAR PAPILLA; COCHLEAR INTEGRITY; TECTORIAL MEMBRANE; DAMAGE
AB Commercially available chickens fall into two categories: egg layers and broilers. Durham et a]. (Hear. Res. 166 (2002) 82-95) showed that despite similar noisy living environments, cochleae of most adult broilers show extensive damage, while cochleae of adult egg layers are largely normal. This finding suggests that egg layers and broilers differ in their susceptibility to noise damage. Here, we evaluate breed differences in susceptibility to acoustic trauma. Young egg layers and broilers (10-17 weeks) were exposed to a 1500 Hz pure tone (120 dB SPL; 24 h) and killed 24 or 72 h later. Cochleae were prepared for scanning electron microscopy and photomicrographs of the cochlear surface were used to determine location and severity of damage. Cochleae were grouped based upon damage severity (moderate or severe). While location and area of damage were similar between both breeds at each recovery time, cochlear damage at 72 h was more extensive than at 24 h. We found no quantitative breed differences within either damage category or recovery time. However, more egg layers (25/27) than broilers (16/32) displayed severely damaged cochleae. Our findings conflict with those reported by Durham et al. (2002). Our results identify a breed-dependent difference in susceptibility to acute sound exposure, with young egg layers displaying increased sensitivity. (c) 2004 Elsevier B. V. All rights reserved.
C1 Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66103 USA.
Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, Kansas City, KS 66103 USA.
RP Durham, D (reprint author), Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66103 USA.
EM ddurham@kumc.edu
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Smittkamp SE, 2002, HEARING RES, V170, P139, DOI 10.1016/S0378-5955(02)00486-0
NR 53
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 101
EP 111
DI 10.1016/j.heares.2004.11.004
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300012
PM 15855035
ER
PT J
AU van Ruijven, MWM
de Groot, JCMJ
Hendriksen, F
Smoorenburg, GF
AF van Ruijven, MWM
de Groot, JCMJ
Hendriksen, F
Smoorenburg, GF
TI Immunohistochemical detection of platinated DNA in the cochlea of
cisplatin-treated guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE cisplatin ototoxicity; cisplatin-DNA adducts; cochlea; guinea pig; organ
of Corti; stria vascularis
ID X-RAY-MICROANALYSIS; STRIA VASCULARIS; ELECTRON-MICROSCOPY; OTOTOXICITY;
LOCALIZATION; DEGENERATION; ADDUCTS; CIS-DIAMMINEDICHLOROPLATINUM(II);
CRYOULTRAMICROTOMY; MORPHOLOGY
AB Cisplatin-induced ototoxicity is correlated with functional and morphological changes in the organ of Corti, the stria vascularis and the spiral ganglion. However, the cochlear sites of cisplatin uptake and accumulation have not been property identified. Therefore, we have developed an immunohistochemical method to, indirectly, detect cisplatin in semithin cryosections of the guinea pig cochlea (basal turn) using an antiserum containing antibodies against cisplatin-DNA adducts. Platinated DNA was present in the nuclei of most cells in the organ of Corti and the lateral wall after cisplatin administration. Nuclear immunostaining was most pronounced in the outer hair cells, the marginal cells and the spiral ligament fibrocytes. This study is the first to demonstrate the presence of cisplatin in histological sections of the cochlea. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Utrecht, Med Ctr, Dept Otorhinolaryngol, Hearing Res Labs, NL-3508 GA Utrecht, Netherlands.
RP van Ruijven, MWM (reprint author), Univ Utrecht, Med Ctr, Dept Otorhinolaryngol, Hearing Res Labs, Room G02-531,POB 85-500, NL-3508 GA Utrecht, Netherlands.
EM m.vanruijven@kmb.azu.nl
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WELB R, 1995, THESIS UNIV DUSSELDO
NR 37
TC 22
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 112
EP 121
DI 10.1016/j.heares.2004.12.007
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300013
PM 15855036
ER
PT J
AU Hine, JE
Thornton, ARD
AF Hine, JE
Thornton, ARD
TI Transient evoked otoacoustic emissions recorded using maximum length
sequences from patients with sensorineural hearing loss
SO HEARING RESEARCH
LA English
DT Article
DE evoked otoacoustic emissions; maximum length sequences; hearing loss
ID STIMULUS RATE; THRESHOLDS; NOISE
AB Much research has shown that transient evoked otoacoustic emissions (TEOAEs) can successfully separate normally hearing and hearing impaired populations. However, this finding comes from TEOAEs recorded using conventional averaging at low stimulation rates. Presenting clicks according to maximum length sequences (MLSs) enables TEOAEs to be recorded at very high stimulation rates. This study compares conventional and MLS TEOAEs in normally hearing and hearing impaired adults. Stimulus presentation rates of 40 clicks/s (conventional) and 5000 clicks/s (MLS) were used. The 'linear' TEOAEs (i.e., the directly recorded waveforms), the 'level nonlinear' (LNL) TEOAEs (i.e., those derived from two linear waveforms separated by a known difference in stimulus level) and the 'rate nonlinear' (RNL) TEOAEs (i.e., obtained by subtracting the emission recorded at 5000 clicks/s from that at 40 clicks/s at a fixed stimulus level) were examined to compare how they separated the normally hearing and hearing impaired subjects. When compared to the results for both conventional and MLS linear or LNL TEOAEs, the present study found that the RNL results best reflected the patients' hearing loss, although the conventional linear and LNL responses performed nearly as well. Only two impaired ears (2%), both with a best threshold of 30 dB HL at 1000 Hz, produced RNL responses with amplitude within the range produced by 95% of the normal group. (c) 2004 Elsevier B.V. All rights reserved.
C1 Royal S Hants Hosp, MRC, Inst Hearing Res, Southampton SO14 0YG, Hants, England.
RP Hine, JE (reprint author), Royal S Hants Hosp, MRC, Inst Hearing Res, Southampton SO14 0YG, Hants, England.
EM j.kwint@soton.ac.uk
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NR 24
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 122
EP 133
DI 10.1016/j.heares.2004.11.019
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300014
PM 15855037
ER
PT J
AU Sharma, A
Dorman, MF
Kral, A
AF Sharma, A
Dorman, MF
Kral, A
TI The influence of a sensitive period on central auditory development in
children with unilateral and bilateral cochlear implants
SO HEARING RESEARCH
LA English
DT Article
DE central auditory development; sensitive period; PI cortical auditory
evoked potential; cochlear implant; bilateral implants
ID CORTICAL MATURATION; EVOKED-POTENTIALS; NORMAL-HEARING; BRAIN-STEM;
CORTEX; PLASTICITY; DEAFNESS; DEPRIVATION; PERCEPTION; RESPONSES
AB We examined the longitudinal development of the cortical auditory evoked potential (CAEP) in 21 children who were fitted with unilateral cochlear implants and in two children who were fitted with bilateral cochlear implants either before age 3.5 years or after age 7 years. The age cut-offs (<3.5 years for early-implanted and >7 years for late-implanted) were based on the sensitive period for central auditory development described in [Ear Hear. 23 (6), 532.] Our results showed a fundamentally different pattern of development of CAEP morphology and PI cortical response latency for early- and late-implanted children. Early-implanted children and one child who received bilateral implants by age 3.5 years showed rapid development in CAEP waveform morphology and PI latency. Late-implanted children showed aberrant waveform morphology and significantly slower decreases in P1 latency postimplantation. In the case of a child who received his first implant by age 3.5 years and his second implant after age 7 years, CAEP responses elicited by the second implant were similar to late-implanted children. Our results are consistent with animal models of central auditory development after implantation and confirm the presence of a relatively brief sensitive period for central auditory development in young children. 2005 Elsevier B.V. All rights reserved.
C1 Univ Texas, Callier Ctr Commun Disorders, Dallas, TX 75206 USA.
Arizona State Univ, Tempe, AZ 85287 USA.
Univ Klinikum Hamburg Eppendorf, Inst Neurophysiol & Pathophysiol, Hamburg, Germany.
RP Sharma, A (reprint author), Univ Texas, Callier Ctr Commun Disorders, 1966 Inwood Rd, Dallas, TX 75206 USA.
EM anu.sharma@utdallas.edu
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NR 42
TC 159
Z9 172
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 134
EP 143
DI 10.1016/j.heares.2004.12.010
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300015
PM 15855038
ER
PT J
AU Lelbovici, M
Verpy, E
Goodyear, RJ
Zwaenepoel, I
Blanchard, S
Laine, S
Richardson, GP
Petit, C
AF Lelbovici, M
Verpy, E
Goodyear, RJ
Zwaenepoel, I
Blanchard, S
Laine, S
Richardson, GP
Petit, C
TI Initial characterization of kinocilin, a protein of the hair cell
kinocilium
SO HEARING RESEARCH
LA English
DT Article
DE kinocilin; kinocilium; stereocilia; inner ear; testis; manchette;
microtubules
ID INNER-EAR; MYOSIN-VIIA; STEREOCILIARY BUNDLES; SENSORY EPITHELIA;
SUPPORTING CELLS; APICAL-SURFACE; MOUSE; MICROTUBULES; COCHLEA; ORGAN
AB A subtracted library prepared from vestibular sensory areas [Nat. Genet. 26 (2000) 51] was used to identify a 960 bp murine transcript preferentially expressed in the inner ear and testis. The cDNA predicts a basic 124 aa protein that does not share any significant sequence homology with known proteins. Immunofluorescence and immunoelectron microscopy revealed that the protein is located mainly in the kinocilium of sensory cells in the inner ear. The protein was thus named kinocilin. In the mouse, kinocilin is first detected in the kinocilia of vestibular and auditory hair cells at embryonic days 14.5, and 18.5, respectively. In the mature vestibular hair cells, kinocilin is still present in the kinocilium. As the auditory hair cells begin to lose the kinocilium during postnatal development, kinocilin becomes distributed in an annular pattern at the apex of these cells, where it co-localizes with the tubulin belt [Hear. Res. 42 (1989) 1]. In mature auditory hair cells, kinocilin is also present at the level of the cuticular plate, at the base of each stereocilium. In addition, as the kinocilium regresses from developing auditory hair cells, kinocilin begins to be expressed by the pillar cells and Deiters cells, that both contain prominent transcellular and apical bundles of microtubules. By contrast, kinocilin was not detected in the supporting cells in the vestibular end organs. The protein is also present in the manchette of the spermatids, a transient structure enriched in interconnected microtubules. We propose that kinocilin has a role in stabilizing dense microtubular networks or in vesicular trafficking. 2005 Published by Elsevier B.V.
C1 Inst Pasteur, INSERM, U587, Unite Genet Deficits Sensoriels, F-75724 Paris, France.
Univ Sussex, Sch Biol Sci, Brighton BN1 9QG, E Sussex, England.
RP Lelbovici, M (reprint author), Inst Pasteur, INSERM, U587, Unite Genet Deficits Sensoriels, 25 Rue Dr Roux, F-75724 Paris, France.
EM mleibo@pasteur.fr
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NR 42
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 144
EP 153
DI 10.1016/j.heares.2004.12.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300016
ER
PT J
AU Falkenius-Schmidt, K
Rydmarker, S
Horner, KC
AF Falkenius-Schmidt, K
Rydmarker, S
Horner, KC
TI Hyperprolactinemia in some Meniere patients even in the absence of
incapacitating vertigo
SO HEARING RESEARCH
LA English
DT Article
DE Meniere's disease; stress; hyperprolactinemia; pituitary adenoma;
hearing; vertigo
ID PROLACTIN RECEPTOR; STRESS; HORMONES; DISEASE; SYSTEM; VASOPRESSIN;
HOMEOSTASIS; GUIDELINES; DISORDERS; DIZZINESS
AB Stress can be a significant factor influencing ear pathologies and is often reported to trigger the symptoms of Meniere's disease. Both physiological and psychological stress provokes the release of prolactin from the pituitary thus allowing the classification of prolactin as a major stress hormone. We investigated the level of the stress hormone prolactin in a Swedish population with early symptoms of Meniere's disease. The median prolactin level in the Meniere patients (n = 33) was not significantly different from that of non-Meniere patients (n = 23). However, in the Meniere group one female (90 year old) had prolactin levels in the upper normal range for women, one male (77 year old) had prolactin levels above the normal limit for men, and a third patient (76 year old female) presented hyper prolactinemia with more than twice the normal level. MR1 confirmed a pituitary adenoma in this patient. This study provides further support for the recent report of hyperprolactinemia in some patients with long-standing Meniere's disease and presenting incapacitating vertigo in France. The data emphasize the likely implication of stress in this pathology where the stress hormone prolactin is likely to represent one actor in a complex hormonal imbalance affecting the inner ear. (c) 2004 Elsevier B.V. All rights reserved.
C1 Angelholm Hosp, Dept Otorhinolaryngol, SE-26281 Angelholm, Sweden.
Malmo Univ Hosp, Dept Otorhinolaryngol, SE-20502 Malmo, Sweden.
CNRS, UMR 6153, Fac Sci St Jerome, Lab Physiol Neurovegetat, F-13397 Marseille, France.
RP Falkenius-Schmidt, K (reprint author), Angelholm Hosp, Dept Otorhinolaryngol, SE-26281 Angelholm, Sweden.
EM karolina.falkenius@telia.com
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NR 38
TC 4
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 154
EP 158
DI 10.1016/j.heares.2004.11.015
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300017
PM 15855040
ER
PT J
AU Irfan, N
Zhang, HM
Wu, SH
AF Irfan, N
Zhang, HM
Wu, SH
TI Synaptic transmission mediated by ionotropic glutamate, glycine and GABA
receptors in the rat's ventral nucleus of the lateral lemniscus
SO HEARING RESEARCH
LA English
DT Article
DE auditory system; intracellular recording; AMPA receptor; postsynaptic
potential; brain slice
ID AUDITORY BRAIN-STEM; SUPERIOR OLIVARY COMPLEX; IN-SITU HYBRIDIZATION;
BAT EPTESICUS-FUSCUS; BUSHY CELL AXONS; BIG BROWN BAT; INFERIOR
COLLICULUS; COCHLEAR NUCLEUS; GUINEA-PIG; PHYSIOLOGICAL-PROPERTIES
AB The synaptic pharmacology of the ventral nucleus of the lateral lemniscus (VNLL) was investigated in brain slices obtained from rat's of 14-37 days old using intracellular recording techniques. Excitatory and inhibitory synaptic potentials (EPSPs and IPSPs) were elicited by electrical stimulation of the lemniscal pathway and recorded from neurons with five types of intrinsic firing patterns (onset, pause, adapting, regular and bursting types). Synaptic receptors that mediated the EPSPs and IPSPs were identified using AMPA, NMDA, GABA(A) and glycine receptor antagonists. The early/short EPSPs were mediated by AMPA receptors. The late/long EPSPs, encountered only in neurons of younger animals, were mediated by NMDA receptors. The IPSPs in most neurons were mediated by glycine receptors. In some neurons the IPSPs were mediated by GABA(A) receptors or both glycine and GABA(A) receptors. The temporal dynamics of fast AMPA EPSPs and glycinergic IPSPs were very similar. AMPA EPSPs and glycinergic (and/or GABAergic) IPSPs could be encountered in a single neuron. The results suggest that the VNLL not only relays incoming signals rapidly from the lower brainstem to the inferior colliculus, but also integrates excitatory and inhibitory inputs to modify and process auditory information. (c) 2004 Elsevier B.V. All rights reserved.
C1 Carleton Univ, Inst Neurosci, Ottawa, ON K1S 5B6, Canada.
RP Wu, SH (reprint author), Carleton Univ, Inst Neurosci, 335 Life Sci Res Bldg,1125 Colonel Dr, Ottawa, ON K1S 5B6, Canada.
EM shwu@ces.carleton.ca
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NR 76
TC 10
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 159
EP 171
DI 10.1016/j.heares.2004.11.021
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300018
PM 15855041
ER
PT J
AU Su, MC
Lee, SY
Tan, CT
Su, CC
Li, SY
Lin, RH
Hung, CC
Lin, MJ
AF Su, MC
Lee, SY
Tan, CT
Su, CC
Li, SY
Lin, RH
Hung, CC
Lin, MJ
TI Taicatoxin inhibits the calcium-dependent slow motility of mammalian
outer hair cells
SO HEARING RESEARCH
LA English
DT Article
DE taicatoxin; outer hair cell; motility; calcium channels
ID GUINEA-PIG COCHLEA; CA2+ CHANNELS; MECHANICAL RESPONSES; ACETYLCHOLINE;
AMPLIFIER; SUBUNIT; RELEASE; PROTEIN
AB The effects of taicatoxin on the slow motility of isolated outer hair cells of guinea pig were studied in the experiments. Pretreatment with taicatoxin (0. 19 mu M) was able to prevent both the cell shortening induced by high K+ (50mM), and the cell elongation induced by ionomycin (10 mu M). These effects of taicatoxin can be mimicked by pretreatment of cells with Ca2+-free medium on the slow motility in response to ionomycin or high K+. Pretreatment with neither calcium channel blockers such as nifedipine (L-type blocker), omega-conotoxin GVIA (N-type blocker), and omega-agatoxin IVA (P-type blocker); nor potassium channel blockers, such as tetraethylammonium chloride (TEA) and 3,4-diaminopyridine (3,4-DAP) can antagonize the cell shortening effect induced by high K+ and cell elongation induced by ionomycin. The calcium-imaging experiment indicated that taicatoxin, but not nifedipine, did prevent an increase of intracellular Ca2+ level significantly induced by high K+. These results demonstrate that the effect of taicatoxin was to block the calcium entry through calcium channels of cell membrane, without relative to its properties of potassium channel blockers. We conclude that taicatoxin-sensitive-calcium channels at least impart, play a significant role in the slow motility of outer hair cell. (c) 2004 Elsevier B.V. All rights reserved.
C1 Chung Shan Med Univ, Dept Life Sci, Taichung 402, Taiwan.
Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan.
RP Lin, MJ (reprint author), Chung Shan Med Univ, Dept Life Sci, 110,Sec 1,Chien Kuo N Rd, Taichung 402, Taiwan.
EM mjl@csmu.edu.tw
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NR 31
TC 0
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 172
EP 179
DI 10.1016/j.heares.2004.12.003
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300019
PM 15855042
ER
PT J
AU Rask-Andersen, H
Bostrom, M
Gerdin, B
Kinnefors, A
Nyberg, G
Engstrand, T
Miller, JM
Lindholm, D
AF Rask-Andersen, H
Bostrom, M
Gerdin, B
Kinnefors, A
Nyberg, G
Engstrand, T
Miller, JM
Lindholm, D
TI Regeneration of human auditory nerve. In vitro/in video demonstration of
neural progenitor cells in adult human and guinea pig spiral ganglion
SO HEARING RESEARCH
LA English
DT Article
DE spiral ganglion; in vitro culture; regeneration; stem cells; human
ID EAR SENSORY NEURONS; STEM-CELLS; INNER-EAR; HAIR-CELLS; NEUROTROPHIC
FACTOR; GROWTH-FACTOR; COCHLEAR IMPLANTATION; DOPAMINERGIC-NEURONS;
INNERVATION; SYSTEM
AB Time lapse video recordings of cultured adult human and guinea pig spiral ganglion (hSG and gpSG) show that mitogen responsive progenitor/stem cells develop in the form of spheres that proliferate and differentiate into mature neurons and glia cells. Neurospheres, cultured with EGF and bFGF showed expression of nestin and incorporation of 5 '-Bromo-2-deoxyuridine (BrdU). Newly formed BrdU labelled cells were positive for beta-tubulin, and also for GFAP demonstrating that neuronal cells were derived from a dividing population of progenitor cells. Dissociated spheres cultured either with glia cell line-derived neurotrophic factor (GDNF) or brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), induced differentiation of the progenitor cells. Video microscopy showed that neurons develop from subcultured spheres maintained for up to four weeks. Neurons showed fasciculation and migration with a speed of 10-30 mu m/h, and some cells had up to 6 mm long neurites coexpressing TrkB and TrkC receptors. Precise dissection suggests that the neurons formed are cochlea-specific. The results suggest that the mammalian auditory nerve has the capability for self-renewal and replacement. Transplantation of progenitor cells together with established means to induce neural differentiation and fiber growth may facilitate strategies for better repair and treatment of auditory neuronal damage. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Uppsala Hosp, Dept Otosurg, S-75185 Uppsala, Sweden.
Univ Uppsala Hosp, Dept Plast Surg, Uppsala, Sweden.
Univ Uppsala Hosp, Dept Neurosurg, Uppsala, Sweden.
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
BMC Uppsala Univ, Neurobiol Unit, Dept Neurosci, Uppsala, Sweden.
RP Rask-Andersen, H (reprint author), Univ Uppsala Hosp, Dept Otosurg, S-75185 Uppsala, Sweden.
EM helge.rask-andersen@akademiska.se
RI Lindholm, Dan/B-3777-2014
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NR 48
TC 70
Z9 74
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 180
EP 191
DI 10.1016/j.heares.2004.12.005
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300020
PM 15855043
ER
PT J
AU Ohashi, T
Ochi, K
Nishino, H
Kenmochi, M
Yoshida, K
AF Ohashi, T
Ochi, K
Nishino, H
Kenmochi, M
Yoshida, K
TI Recovery of human compound action potential using a paired-click
stimulation paradigm
SO HEARING RESEARCH
LA English
DT Article
DE human compound action potential (CAP); synaptic function; CAP recovery;
adaptation; paired click stimulation
ID AUDITORY-NERVE FIBERS; UNANESTHETIZED DECEREBRATE CAT; SHORT-TERM
ADAPTATION; NEURAL TRANSDUCTION; SIMULATED ECHOES; RESPONSES; MASKING;
COCHLEAR; NEURONS; RECEPTOR
AB The recovery process from adaptation of the compound action potential (CAP) was studied using an equilevel paired click stimulation paradigm in humans with normal hearing. The CAP amplitude to the second click of paired clicks was normalized to the amplitude to the first click. The second-click CAP amplitude recovered as a function of interclick interval (ICI) between the first and the second click of a pair. A regression line fitted to the recovered amplitude data demonstrated the logarithmic function of the ICI. Full recovery times changed from 118 to 278 ms with increasing click intensity. The regression lines for higher click intensities exhibited two different slopes in two ICI ranges: from 3 to 100 and 120 to 300 ms. We suppose that the CAP recovery for ICI <100 ms is attributable to both the relative refractoriness of auditory nerve and the short-term adaptation mechanisms, while, for ICI >100 ms chiefly to the short-term adaptation mechanisms.
The recovery process of the second-click CAP slowed with increasing intensity, which is a similar result to that obtained in the animal experiments by Parham et al. The input-output (I-O) curve of the second-click CAP amplitudes exhibited a different slopes above and below 60 dB normal hearing level (nHL). We assume that the mechanisms underlying this characteristic curve pattern differ from those for the I-O curve of the CAP in response to single-click stimuli.
We expect that investigating the CAP recovery in pathological ears will provide clinically useful information on cochlear synaptic function. 2005 Elsevier B.V. All rights reserved.
C1 St Marianna Univ, Red Cross Hosp Hadano City, Dept Otorhinolaryngol, Hadano, Kanagawa, Japan.
St Marianna Univ, Sch Med, Dept Prevent Med, Miyamae Ku, Kawasaki, Kanagawa, Japan.
RP Ohashi, T (reprint author), 949-10 Sasagi, Tsukuba, Ibaraki, Japan.
EM toliashi@vc-net.jp
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NR 36
TC 13
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 192
EP 200
DI 10.1016/j.heares.2004.12.001
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300021
PM 15855044
ER
PT J
AU Zhou, XM
Jen, PHS
AF Zhou, XM
Jen, PHS
TI Corticofugal modulation of directional sensitivity in the midbrain of
the big brown bat, Eptesicus fuscus
SO HEARING RESEARCH
LA English
DT Article
DE auditory cortex; bat; corticofugal modulation; directional sensitivity;
frequency; inferior colliculus inhibition
ID INFERIOR COLLICULAR NEURONS; PRIMARY AUDITORY-CORTEX; SOUND PRESSURE
TRANSFORMATION; PATTERNED PULSE TRAINS; SPACE REPRESENTATION; HOUSE
MOUSE; GUINEA-PIG; FM BAT; FREQUENCY REPRESENTATION; DESCENDING
PROJECTIONS
AB In our recent Study of corticofugal modulation of collicular amplitude sensitivity of the big brown bat, Eptesicus fuscus, we suggested that the corticofugal modulation is based upon the best frequency (BF) differences and the relative amplitude sensitivity difference between collicular (IC) and cortical (AC) neurons but not the absolute amplitude sensitivity of IC and AC neurons. To show that corticofugal modulation is systematic and multiparametric, we studied corticofugal modulation of directional sensitivity in 89 corticofugally inhibited IC neurons in the same bat species under free field stimulation conditions. A neuron's directional sensitivity was expressed with the azimuthal range (AR) at 50%, below the maximum of each directional sensitivity Curve and the best azimuth (BAZ) at which the neuron discharged maximally. Cortical electrical stimulation did not affect the directional sensitivity of 40 (45%) neurons with BFIC-Ac differences of 7.3 +/- 4.4 kHz but sharpened the directional sensitivity of other 49 (55%) neurons with BFIC-Ac differences of 2.3 +/- 1.8 kHz. Corticofugal modulation sharpened directional sensitivity curves of IC neurons by decreasing the AR and shifting collicular BAZ toward cortical BAZ. The decrease in AR and the shift in BAZ increased significantly with AR(IC-Ac) and BAZ(IC-Ac) differences but not with absolute AR and BAZ of IC and AC neurons or BFIC-Ac differences. Corticofual modulation also shifted collicular BF toward cortical BF. The shift in BF increased significantly with BFIC-Ac differences but not with the BF of IC and AC neurons or BAZ shift. Consonant with out- previous study, these data indicate that corticofugal modulation of collicular directional sensitivity is based on topographic projections between the IC and the AC and the difference in directional sensitivity but not the absolute directional sensitivity of IC or AC neurons. (c) 2005 Elsevier B.V. All rights reserved.
C1 Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
Univ Missouri, Interdisciplinary Neurosci Program, Columbia, MO 65211 USA.
RP Jen, PHS (reprint author), Univ Missouri, Div Biol Sci, 208 Lefevre Hall, Columbia, MO 65211 USA.
EM jetip@missouri.edu
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NR 90
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAY
PY 2005
VL 203
IS 1-2
BP 201
EP 215
DI 10.1016/j.heares.2004.12.008
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 927BB
UT WOS:000229166300022
PM 15855045
ER
PT J
AU Kubli, LR
Leek, MR
Dreisbach, LE
AF Kubli, LR
Leek, MR
Dreisbach, LE
TI Acoustic reflexes to Schroeder-phase harmonic complexes in
normal-hearing and hearing-impaired individuals
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 23rd Midwinter Research Meeting of the
Association-for-Research-in-Otolaryngology
CY FEB 20-24, 2000
CL ST PETERSBURG BEACH, FL
SP Assoc Res Otolaryngol
DE acoustic reflex; cochlear excitation; harmonic complexes; Schroeder
phase
ID STAPEDIUS REFLEX; INNER-EAR; DISPERSION; STIMULI; MASKING; LISTENERS;
RESPONSES; SIGNALS; GROWTH; MODEL
AB Harmonic complexes generated with positive or negative Schroeder-phases may result in differences in cochlear excitation, even though their long-term spectra and amplitudes are equal. As a measure of possible differences in cochlear excitation resulting from these harmonic complexes, thresholds and growth of the acoustic reflex were assessed in normal-hearing and hearing-impaired subjects. Harmonic complexes with fundamental frequencies of 50, 100, and 200 Hz were constructed with positive and negative-Schroeder phases. In normal-hearing subjects, acoustic reflex thresholds for the 50- and 100-Hz fundamental waveforms were typically lower for negative Schroeder-phase complexes than for positive Schroeder phase stimuli. At the highest fundamental frequency of 200 Hz. there were no significant threshold differences due to phase. Hearing-impaired subjects showed a similar pattern for thresholds between the two phase selections, but with smaller differences than those observed in normal-hearing subjects. At levels above reflex threshold, the magnitude of the acoustic reflex was greater for the negative-phase than the positive-phase stimuli for the lowest fundamental frequency, but no significant differences were observed at fundamental frequencies of 100 and 200 Hz. These results are consistent with generally greater cochlear excitation in response to negative than to positive Schroeder-phase stimuli when the fundamental frequency is sufficiently low. Increased excitation may reflect a synchronization of response across a wide band of frequencies in the cochlea when the rate of frequency sweep within periods of these harmonic complexes is appropriately matched to timing characteristics of the traveling wave. (c) 2004 Elsevier B.V. All rights reserved.
C1 Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA.
RP Kubli, LR (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM lina.kubli@na.amedd.army.mil
CR American National Standards Institute (ANSI), 1996, S361996 ANSI
American National Standards Institute (ANSI), 1987, S3391987 ANSI
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NR 26
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 1
EP 12
DI 10.1016/j.heares.2004.08.012
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300001
PM 15811693
ER
PT J
AU Zou, J
Pyykko, M
Sutinen, P
Toppila, E
AF Zou, J
Pyykko, M
Sutinen, P
Toppila, E
TI Vibration induced hearing loss in guinea pig cochlea: expression of
TNF-alpha and VEGF
SO HEARING RESEARCH
LA English
DT Article
DE hearing loss; cytokine; shear stress; spiral ganglion cell; epithelial
cell; organ of corti
ID FLUID SHEAR-STRESS; ENDOTHELIAL GROWTH-FACTOR; GENERATED NOISE-LEVELS;
EAR SURGERY; RESPONSE ELEMENT; CHAIN PROMOTER; DRILL; CELLS; APOPTOSIS;
BONE
AB Transcranial vibration was applied for seven animals at a frequency of 250 Hz for 15 min, and five animals Were used as normal controls to investigate cellular and Molecular mechanism linked to vibration-induced hearing loss in animal model. Compound action potential (CAP) thresholds were measured by round window niche electrode. The expression of tumour necrosis factor alpha (TNF-alpha) and its receptors (TNF R1, TNF R2), vascular endothelium growth factor (VEGF) and its receptors (VEGF R1. VEGF R2) were analysed by immunohistochemistry. Transcranial vibration caused expression of TNF-alpha, TNF R1 and TNF R2 in the cochlea and the expression of TNF R2 was stronger than that of TNF R1. Vibration also induced VEGF and VEGF R2 expression in the cochlea. The average immediate hearing loss was 62 dB and after three days still 48 dB. It is concluded that transcranial vibration as during temporal bone drilling produces cochlear shear stress that is connected With Up-regulation of TNF-alpha. and its receptors. Also VEGF and VEGF R2 are Up-regulated. These responses may be linked to both the damage and repair process of the cochlea. (c) 2004 Elsevier B.V. All rights reserved.
C1 Tampere Univ Hosp, Dept Otolaryngol, FIN-33521 Tampere, Finland.
Karolinska Hosp, Dept Otolaryngol, Ctr Hearing & Commun Res, S-10401 Stockholm, Sweden.
No Karelian Cent Hosp, Dept Phys Med & Rehabil, Joensuu, Finland.
Inst Occupat Hlth, Dept Phys, Helsinki, Finland.
Shanghai Med Univ 2, Xinhua Hosp, Dept Otolaryngol Head & Neck Surg, Shanghai 200092, Peoples R China.
RP Pyykko, M (reprint author), Tampere Univ Hosp, Dept Otolaryngol, FIN-33521 Tampere, Finland.
EM jing.zou@uta.fi; ilmari.pyykko@pshp.fi
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NR 28
TC 32
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 13
EP 20
DI 10.1016/j.heares.2004.10.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300002
PM 15811694
ER
PT J
AU Labbe, D
Teranishi, M
Hess, A
Bloch, W
Michel, O
AF Labbe, D
Teranishi, M
Hess, A
Bloch, W
Michel, O
TI Activation of caspase-3 Is associated with oxidative stress in the
hydropic guinea pig cochlea
SO HEARING RESEARCH
LA English
DT Article
DE hydrops; nitric oxide; oxidative stress; hearing loss
ID NITRIC-OXIDE-SYNTHASE; INOS/NOS-II; APOPTOSIS; EXPRESSION; DEATH;
ISOPROSTANES; MARKERS; GENE
AB The aim of this study was to investigate the involvement of oxidative stress and apoptosis in an animal model of Meniere's disease. Endolymphatic hydrops (ELH) is generally accepted as the decisive histological characteristic of Meniere's disease.
Closure of the endolymphatic duct (Kimura's method) was used to induce endolymphatic hydrops in guinea pigs. Sham-operated animals served as controls. After 4 weeks the animals operated showed a significant elevation of the hearing thresholds as measured by audiometric brainstem responses (ABR) pre- and postoperatively. Immediately after the second ABR measurement, the animals were sacrificed for further immunohistological examinations of the inner ear with specific antibodies to active caspase-3 (cas-3) as a marker for apoptosis and antibodies to 8-isoprostane (8-iso) and nitrotyrosine (NT) as indicators of oxidative stress.
Compared with the sham-operated controls, hydropic cochleae showed strong immumostaining for both oxidative stress markers in spiral ganglion cells, in the blood-vessels and fibrocytes of the lateral wall, as well as in supporting cells of the organ of Corti. Activation of cas-3 in spiral ganglion cells and the lateral wall was found exclusively in hydropic cochleae.
Our findings suggest that oxidative stress is involved in the development of endolymphatic hydrops and may lead to cellular damage which induces apoptosis by activation of cas-3. Apoptotic cell death might contribute to the sensorineural hearing loss found in later stages of Meniere's disease. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Cologne, Dept Otorhinolaryngol, D-50924 Cologne, Germany.
German Sport Univ, Dept Mol & Cellular Sport Med, Cologne, Germany.
RP Labbe, D (reprint author), Univ Cologne, Dept Otorhinolaryngol, Joseph Stelzmann Str 9, D-50924 Cologne, Germany.
EM daniel.labbe@uni-koeln.de; michel@um-koeln.de
RI Teranishi, Masaaki/I-1956-2012; Michel, Olaf/B-3673-2012
OI Michel, Olaf/0000-0003-4289-5693
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NR 38
TC 20
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 21
EP 27
DI 10.1016/j.heares.2004.10.002
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300003
PM 15811695
ER
PT J
AU Hammond, GR
Seth, Y
Ison, JR
AF Hammond, GR
Seth, Y
Ison, JR
TI Concurrent measurement of the detectability of tone bursts and their
effect on the excitability of the human blink reflex using a
probe-signal method
SO HEARING RESEARCH
LA English
DT Article
DE auditory attention; attentional band; olivocochlear bundle; blink
reflex; prepulse inhibition
ID ACOUSTIC STARTLE RESPONSE; OLIVOCOCHLEAR BUNDLE; DETECTING SIGNALS;
RECEPTIVE-FIELDS; INHIBITION; NOISE; PLASTICITY; FREQUENCY; ATTENTION;
RAT
AB The probe-signal method has shown that auditory signals that are either presented more often in a series of trials or that are immediately preceded by cues of the same frequency on a single trial are detected more readily than signals of other frequencies. The frequency range in which detection is favored defines an attentional band, which is thought to result from an effective attenuation of deviant frequencies in the cochlea, possibly by activation of the olivocochlear bundle. In a 2IFC procedure in which the first observation interval was preceded by a 1300-Hz cue, subjects detected cued probe tones (at 1300 Hz) but not uncued probe tones (at 1000 Hz or 1600 Hz) at better than chance levels. Concurrent elicitation of a blink reflex by presentation of an air puff in the first observation interval on a random half of the trials showed that cued probes, but not uncued probes, inhibited the size of the blink reflex. These data show that uncued probes do not enter into the low-level sensory processing in the brainstem which is responsible for reflex modification. This finding is consistent with the view that stimuli whose frequency falls outside an attentional band are excluded at the auditory periphery. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Western Australia, Sch Psychol, Crawley, WA 6907, Australia.
Univ Rochester, Rochester, NY 14627 USA.
RP Hammond, GR (reprint author), Univ Western Australia, Sch Psychol, Crawley, WA 6907, Australia.
EM geoff@psy.uwa.edu.au
RI Hammond, Geoff/H-9343-2014
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NR 34
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 28
EP 34
DI 10.1016/j.heares.2004.07.018
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300004
PM 15811696
ER
PT J
AU Hu, N
Nuttall, AL
Ren, TY
AF Hu, N
Nuttall, AL
Ren, TY
TI Spatial distribution of electrically induced high frequency vibration on
basilar membrane
SO HEARING RESEARCH
LA English
DT Article
DE electromotility; vibration; high frequency; laser Doppler velocimeter;
cochlea; basilar membrane; outer hair cells; guinea pig
ID OUTER HAIR CELL; GUINEA-PIG COCHLEA; OTOACOUSTIC EMISSIONS; MECHANICAL
RESPONSES; PIEZOELECTRIC MODEL; MOTOR PROTEIN; MOTILITY; STIFFNESS;
AMPLIFIER; CURRENTS
AB We reported that the electrically evoked basilar membrane (BM) vibration at frequencies above the best frequency (BF) showed a lowest BM velocity magnitude. called a "dip", in the velocity-frequency spectra, indicating a cancellation. In the present study, we measured the high frequency BM motion as functions of the longitudinal and radial locations. Measurements were taken at three longitudinal locations in the first turn and the hook region: 14.9, 15.8 and 16.8 mm from the apex, corresponding to the BFs of 17, 213 and 28.0 kHz calculated from Greenwood [J. Acoust. Soc. Am. 87, 2592], and at different radial locations across the width of the BM. It was found that the clip frequency (DF) varied with the longitudinal and radial locations. In the longitudinal direction, the average value of the DF was 49.6, 55.6 and 72.8 kHz, respectively. Thus, the longitudinal distribution of the high frequency BM vibration was correlated with the BF. In the radial direction, there was consistent variation of the response spectrum such that the dip was mainly evident in the pectinate zone of the BM. These results imply that the high frequency BM motion is related to mechanical properties of the cochlear partition, including the outer hair cells (OHCs) themselves. Data also indicate different vibration modes across the width of the organ of Corti. (c) 2004 Elsevier B.V. All rights reserved.
C1 Oregon Hlth Sci Univ, Dept Otolaryngol Head & Neck Surg, Oregon Hearing Res Ctr, Portland, OR 97239 USA.
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
RP Nuttall, AL (reprint author), Oregon Hlth Sci Univ, Dept Otolaryngol Head & Neck Surg, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd,NRC04, Portland, OR 97239 USA.
EM nuttall@ohsu.edu
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NR 38
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 35
EP 46
DI 10.1016/j.heares.2004.11.002
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300005
PM 15811697
ER
PT J
AU Soeta, Y
Nakagawa, S
Tonoike, M
AF Soeta, Y
Nakagawa, S
Tonoike, M
TI Auditory evoked magnetic fields in relation to bandwidth variations of
bandpass noise
SO HEARING RESEARCH
LA English
DT Article
DE magnetoencephalography; auditory evoked response; Nlm; bandpass noise;
autocorrelation function
ID ITERATED RIPPLED NOISE; TONOTOPIC ORGANIZATION; PHASE SENSITIVITY; PITCH
STRENGTH; COMPUTER-MODEL; VIRTUAL PITCH; COMPLEX TONES; HUMAN BRAIN;
CORTEX; FREQUENCY
AB Auditory evoked magnetic fields in relation to the bandwidth of bandpass noise were examined by magnetoencephalography (MEG). Pure tone and bandpass noises with center frequencies of 500, 1000 or 2000 Hz were used as the auditory signals. All source signals had the sound pressure level set at 74 dB. The stimulus duration was 0.5 s, with rise and fall ramps of 10 ms. Eight Volunteers with normal hearing took part in the study. Auditory evoked fields were recorded using a neuromagnetometer in a magnetically-shielded room. The results showed that the peak amplitude of Nlm, which was found above the left and right temporal lobes around 100 ms after the Stimulus onset, decreased with increasing bandwidth of the bandpass noise. The latency and estimated equivalent Current dipole (ECD) locations of Nlm did not show any systematic variation as a function of the bandwidth for any of the center frequencies. (c) 2004 Elsevier B.V. All rights reserved.
C1 Natl Inst Adv Ind Sch & Technol, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
RP Soeta, Y (reprint author), Natl Inst Adv Ind Sch & Technol, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
EM y.soeta@aist.go.jp
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NR 41
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 47
EP 54
DI 10.1016/j.heares.2004.09.012
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300006
PM 15811698
ER
PT J
AU Fu, QJ
AF Fu, QJ
TI Loudness growth in cochlear implants: effect of stimulation rate and
electrode configuration
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implants; loudness balance; loudness growth; stimulation rate;
electrode configuration; amplitude mapping
ID PHONEME RECOGNITION; LISTENERS; HEARING; BALANCE
AB In cochlear implant speech processor design, acoustic amplitudes are mapped to electric currents with the intention of preserving loudness relationships across electrodes. Many parameters may affect the growth of loudness with electrical stimulation. The present study measured the effects of stimulation rate and electrode configuration on loudness growth in six Nucleus-22 cochlear implant users. Loudness balance functions were measured for stimuli that differed in terms of stimulation rate, electrode coil figuration and electrode location: a 2-alternative, forced-choice adaptive procedure (double-staircase) was used. First, subjects adaptively adjusted the amplitude of a 100-pulse-per-second (pps) pulse train to match the loudness of a 1000-pps standard Pulse train. For a range of reference stimulation levels, the loudness of the 100-pps stimulus was matched to that of the 1000-pps standard stimulus: loudness balancing was performed for three electrode pairs [(20,22), (1 3) (1,22)]. The results showed that the loudness balance functions between the 100- and 1000-pps stimulation rates were highly subject-dependent. Some subjects' loudness balance functions were logarithmic, while others' were nearly linear. Loudness balance functions were also measured across electrode locations [(20,22) vs. (1,3)] for two stimulation rates (100, 1000 pps). Results showed that the loudness balance functions between the apical and basal electrode pairs highly depended on the stimulation rate. For all subjects, at the 1000-pps rate, the loudness balance functions between the two electrode locations were nearly linear; however, at the 100-pps rate, the loudness balance function was highly nonlinear in two out of six subjects. These results suggest that, for some cochlear implant patients, low-frequency stimulation may be processed differently at different electrode locations-, for these patients, acoustic-to-electric amplitude mapping may need to be sensitive to this place-dependent processing when relatively low stimulation rates Lire used. (c) 2004 Elsevier B.V. All rights reserved.
C1 House Ear Res Inst, Dept Audiory Implants & Percept, Los Angeles, CA 90057 USA.
RP Fu, QJ (reprint author), House Ear Res Inst, Dept Audiory Implants & Percept, 2100 W 3rd St, Los Angeles, CA 90057 USA.
EM qfu@hei.org
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NR 23
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 55
EP 62
DI 10.1016/j.heares.2004.10.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300007
PM 15811699
ER
PT J
AU Muller, M
von Hunerbein, K
Holdis, S
Smolders, JWT
AF Muller, M
von Hunerbein, K
Holdis, S
Smolders, JWT
TI A physiological place-frequency map of the cochlea in the CBA/J mouse
SO HEARING RESEARCH
LA English
DT Article
DE mouse; cochlea; place-frequency map; cochlear nucleus; tonotopy
ID AUDITORY-NERVE FIBERS; BASILAR-MEMBRANE; INFERIOR COLLICULUS;
PACHYUROMYS-DUPRASI; CRITICAL RATIOS; ACOUSTIC FOVEA; HORSESHOE BAT;
SINGLE UNITS; HOUSE-MOUSE; REPRESENTATION
AB Genetically manipulated mice have gained a prominent role in in vivo research on development and function of the auditory system. A prerequisite for the interpretation of normal and abnormal structural Mid functional features of the inner ear is the exact knowledge of the cochlear place-frequency map. Using a stereotaxic approach to the projection site of the auditory nerve fibers ill the cochlear nucleus. we succeeded in labelling physiologically characterized auditory nerve afferents and determined their peripheral innervation site in the cochlea.
From the neuronal characteristic frequency (CF) and the innervation site in the organ of Corti a place-frequency map was established for characteristic frequencies between 7.2 and 61.8 kHz, corresponding to locations between 90% and 10% basilar membrane length (base = 0%, apex = 100%, mean length measured tinder the inner hair cells 5.13 mm). The relation between normalized distance from the base (d) and frequency (kHz) can be described by a simple logarithmic function: d(%) = 156.5 - 82.5 x log(f), With a slope of 1.25 mm/octave of frequency. The present map, recorded tinder physiological conditions, differs from earlier maps determined with different methods. The simple logarithmic place-frequency relation found in the mouse indicates that mice are acoustic generalists rather than specialists. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Frankfurt, Inst Physiol 2, D-60590 Frankfurt, Germany.
RP Smolders, JWT (reprint author), Univ Frankfurt, Inst Physiol 2, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM Jean.Smolders@em.uni-frankfurt.de
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NR 37
TC 112
Z9 113
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 63
EP 73
DI 10.1016/j.heares.2004.08.011
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300008
PM 15811700
ER
PT J
AU Ray, B
Roy, TS
Wadhwa, S
Roy, KK
AF Ray, B
Roy, TS
Wadhwa, S
Roy, KK
TI Development of the human fetal cochlear nerve: a morphometric study
SO HEARING RESEARCH
LA English
DT Article
DE auditory nerve; ontogeny; myelination; asymmetry; stereology
ID HUMAN FETUSES; SCHWANN-CELL; TIME-COURSE; HAIR-CELLS; GUINEA-PIG;
MYELINATION; INNERVATION; MATURATION; HEARING; FIBERS
AB Ontogenesis of the human peripheral auditory pathway is relatively less explored. While the distal part of the auditory perception apparatus (i.e. the cochlea) received attention, studies on the neural element carrying information to the brainstem (i.e. the cochlear nerve) are scarce. In the present study, axonal differentiation, maturation and myelination of the distal end of the human cochlear nerve (CN) were assessed using light and electron microscopy. Seven human fetuses of 12, 15, 18 20, 22 28 and 38 weeks' gestation (WG) were analyzed. Light microscopy revealed nerve fascicles as early as 12 WG, initially arranged loosely but later compacted by 18 WG. Myelinated fibers were clearly detected at 28 WG. Ultrastructurally, at 12 WG developing Schwann cells were present between the thin unmyelinated axons. At 15 WG, the fascicular arrangement was distinct with blood vessels in the perineurium. The maximum number of axons was found at 20 WG, which subsequently reduced to reach the adult level at 22 WG. The myelinated axons in the CN were first observed on the left side at 20 WG, following which the number and proportion of myelinated axons increased until term, incorporating both small and large axons. The right CN lagged behind in maturation. Axon size also increased with age. Thus, the maturation of the human CN commences during the mid-gestation period and produces exuberant axons that are eventually pruned at a time when axons start to myelinate. During this developmental period the human CN maintains maturational asymmetry, the functional consequences of which remain to be elucidated. (c) 2004 Elsevier B.V. All rights reserved.
C1 All India Inst Med Sci, Dept Anat, New Delhi 110029, India.
All India Inst Med Sci, Dept Obstet & Gynecol, New Delhi 110029, India.
RP Roy, TS (reprint author), All India Inst Med Sci, Dept Anat, New Delhi 110029, India.
EM tarasankar@hotmail.com
RI Ray, Bappaditya/F-4489-2014; Ray, Bappaditya/O-2556-2014
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NR 59
TC 14
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 74
EP 86
DI 10.1016/j.heares.2004.09.013
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300009
PM 15811701
ER
PT J
AU Carlsson, PI
Van Laer, L
Borg, E
Bondeson, ML
Thys, M
Fransen, E
Van Camp, G
AF Carlsson, PI
Van Laer, L
Borg, E
Bondeson, ML
Thys, M
Fransen, E
Van Camp, G
TI The influence of genetic variation in oxidative stress genes on human
noise susceptibility
SO HEARING RESEARCH
LA English
DT Article
DE hearing loss; noise induced hearing loss; reactive oxygen species;
antioxidant; genetic polymorphisms; glutathione-S-transferase; catalase;
supeioxide dismutase; glutathione peroxidase; glutathione reductase
ID INDUCED HEARING-LOSS; GLUTATHIONE-S-TRANSFERASE; INCREASES
SUSCEPTIBILITY; MICE; ASSOCIATION; EXPOSURE; POLYMORPHISMS;
ANTIOXIDANTS; MUTATION; DISEASE
AB Noise induced hearing loss (NIHL) is a complex disease Caused by an interaction between genetic and environmental factors. Damage in the cochlea as a result of noise exposure appears to be mediated by reactive oxygen species (ROS). To investigate whether genetic variation in the human protective antioxidant system is associated with high or low susceptibility to NIHL genetic polymorphisms derived from genes involved in the oxidative stress response were analysed in the 10% most susceptible and 10% most resistant extremes of 1200 Swedish noise-exposed workers. The genetic polymorphisms included 2 deletion polymorphisms for the GSTM1 and GSTT1 gene, and 14 SNPs derived from the CAT, SOD, GPX, GSR and GSTP1 genes. No significant differences were found between susceptible and resistant groups, providing no support for a major role of genetic variation of antioxidant enzymes in the susceptibility to NIHL. (c) 2004 Elsevier B.V. All rights reserved.
C1 Orebro Univ Hosp, Dept Audiol, SE-70116 Orebro, Sweden.
Orebro Univ Hosp, Ahlsen Res Inst, SE-70116 Orebro, Sweden.
Univ Antwerp, Dept Med Genet, B-2610 Antwerp, Belgium.
Univ Uppsala, Dept Genet & Pathol, Rudbeck Lab, SE-75185 Uppsala, Sweden.
RP Carlsson, PI (reprint author), Orebro Univ Hosp, Dept Audiol, POB 1613, SE-70116 Orebro, Sweden.
EM per-inge.carlsson@orebroll.se
RI Van Camp, Guy/F-3386-2013; Fransen, Erik/C-4102-2015
OI Van Camp, Guy/0000-0001-5105-9000; Fransen, Erik/0000-0001-7785-4790
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NR 39
TC 35
Z9 48
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 87
EP 96
DI 10.1016/j.heares.2004.09.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300010
PM 15811702
ER
PT J
AU Meyer, J
Preyer, S
Hofmann, SI
Gummer, AW
AF Meyer, J
Preyer, S
Hofmann, SI
Gummer, AW
TI Tonic mechanosensitivity of outer hair cells after loss of tip links
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; stereocilia; channel gating; caged calcium; mechanoelectrical
transduction dihydrostreptomycin
ID GUINEA-PIG COCHLEA; MECHANOELECTRICAL TRANSDUCTION; CALCIUM CHELATION;
ION CHANNELS; MECHANOTRANSDUCER CHANNEL; STEREOCILIARY BUNDLE; MOUSE
COCHLEA; CROSS-LINKS; CURRENTS; ADAPTATION
AB Tip links-the extracellular connectors between the distal ends of adjacent stereocilia - are essential for the first mechanical gating hair-cell transducer channels. Transduction in the absence of tip links was investigated for outer hair cells of the adult guiea-pig, cochlea by patch-clamp recordings of the whole-cell current during mechanical stimulation of the hair bundle. Loss of tip links induced by application of BAPTA led to permanently opened transducer channels, as evidenced by a constant inward current, loss of response to sinusoidal mechanical deflection of the hair bundle and block by the open-channel blocker dihydrostreptomycin (100 mu M). Step deflection of the hair bundle (200-500 nm) in the inhibitory direction exponentially reduced this current to a constant value with time constant, tau(on), of the order of seconds. The Current returned exponentially to the pre-stimulus level with time-constant, tau(off), also of the order of seconds. tau(on) was dependent on the inter-stimulus interval, Delta t, such that reducing this interval below about 40 s resulted in an exponentially faster response. tau(off) was independent of At. Application of the calcium ionophore, ionomycin (10 mu M), showed that tau(on) became independent of Delta t after saturating elevation of the intracellular Ca(2+) concentration. Flash-photolytic release of intracellular caged calcium (25-mu M NP-EGTA/AM) showed that tau(on) is dependent on intracellular Ca(2+) concentration. These experiments imply an intracellular, calcium-dependent gating mechanism for hair-cell transducer channels. (c) 2004 Elsevier B.V. All results reserved.
C1 Univ Tubingen, Sect Physiol Acoust & Commun, Dept Otolaryngol, D-72076 Tubingen, Germany.
RP Gummer, AW (reprint author), Univ Tubingen, Sect Physiol Acoust & Commun, Dept Otolaryngol, Elfriede Aulhorn Str 5, D-72076 Tubingen, Germany.
EM anthony.gummer@uni-tuebingen.de
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NR 74
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 97
EP 113
DI 10.1016/j.heares.2004.11.013
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300011
PM 15811703
ER
PT J
AU Harkrider, AW
Hedrick, MS
AF Harkrider, AW
Hedrick, MS
TI Acute effect of nicotine on auditory gating in smokers and non-smokers
SO HEARING RESEARCH
LA English
DT Article
DE cholinergic; nAChRs; transdermal nicotine; mismatch negativity; auditory
gating
ID CORTICAL EVOKED-POTENTIALS; OUTER HAIR-CELLS; SCHIZOPHRENIC-PATIENTS;
TOBACCO SMOKING; SUBCUTANEOUS NICOTINE; CIGARETTE-SMOKING; ACOUSTIC
CHANGE; RAT; NORMALIZATION; PERFORMANCE
AB This paper investigates the role of cholinergic mechanisms in auditory gating by assessing the acute effects of nicotine, an acetylcholinomimetic drug, on behavioral and electrophysiological measures of consonant-vowel (CV) discrimination in quiet and in broadband noise (BBN). fit a single-blind procedure, categorical boundaries and mismatch negativity (MMN) in two conditions (quiet, BBN) were obtained from 10 non-smokers and 4 smokers with normal hearing under two drug conditions (nicotine, placebo). After the nicotine sessions, plasma tests revealed a subject's nicotine concentration and subjects reported any symptoms. Larger MMN areas and steeper slopes at the boundary were interpreted as reflecting better electrophysiological and behavioral CV discrimination, respectively. Results indicate that, in non-smokers, the effects of nicotine on electrophysiological CV discrimination in quiet increase with an increase in severity of symptoms. Specifically, asymptomatic non-smokers (N = 5) demonstrate little improvement (and sometimes decrements) in performance while symptomatic non-smokers (N = 5) exhibit nicotine-enhanced discrimination, as do smokers. In noise, all subjects demonstrate nicotine-enhanced behavioral and electrophysiological discrimination. Additionally, in noise, smokers exhibit a larger number of measurable categorical boundaries as well as larger MMN areas than non-smokers in both placebo and nicotine sessions. Results are consistent with the hypothesis that nicotinic cholinergic mechanisms play a role in the gating of auditory stimuli. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Tennessee, Dept Speech Pathol & Audiol, Knoxville, TN 37996 USA.
RP Harkrider, AW (reprint author), Univ Tennessee, Dept Speech Pathol & Audiol, 578 S Stadium Hall, Knoxville, TN 37996 USA.
EM aharkrid@utk.edu
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NR 57
TC 35
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 114
EP 128
DI 10.1016/j.heares.2004.11.009
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300012
PM 15811704
ER
PT J
AU Turner, JG
Hughes, LF
Caspary, DM
AF Turner, JG
Hughes, LF
Caspary, DM
TI Divergent response properties of layer-V neurons in rat primary auditory
cortex
SO HEARING RESEARCH
LA English
DT Article
DE layer V; rat; primary auditory cortex; pyramidal; extracellular;
receptive field; juxtacellular
ID GERBIL MERIONES-UNGUICULATUS; INFERIOR COLLICULAR NEURONS; INTRINSIC
FIRING PATTERNS; SUPERIOR OLIVARY COMPLEX; BIG BROWN BAT; CORTICOFUGAL
MODULATION; PYRAMIDAL NEURONS; CORTICOCORTICAL CONNECTIONS;
FUNCTIONAL-ORGANIZATION; COMMISSURAL CONNECTIONS
AB Layer-V pyramidal cells comprise a major output of primary auditory cortex (Al). At least two cell types displaying different morphology, projections and in vitro physiology have been previously identified in layer-V. The focus of the present study was to characterize extracellular receptive field properties of layer-V neurons to determine whether a similar breakdown of responses can be found in vivo. Recordings from 105 layer-V neurons revealed two predominant receptive field types. Thirty-two percent displayed strong excitatory V/U-shaped receptive field maps and spiking patterns with shorter stimulus-driven interspike intervals (ISIs), reminiscent of the bursting cells discussed in the in vitro literature. V/U-shaped maps remained relatively unchanged across the three sequential repetitions of the map run on each neuron. Neurons with V/U-shaped maps were also easily depolarized with extracellular current pulse stimulation. In contrast, 47% of the neurons displayed Complex receptive field maps characterized by weak and/or inconsistent excitatory regions and were difficult to depolarize with current pulses. These findings suggest that V/U-shaped receptive fields could correspond to previously described intrinsic bursting (M) cells with corticotectal projections, and that neurons with Complex receptive fields might represent the regular spiking (RS) cells with their greater inhibitory input and corticocortical/corticostriatal projection pattern. (c) 2004 Elsevier B.V. All rights reserved.
C1 So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA.
So Illinois Univ, Sch Med, Dept Surg, Springfield, IL 62794 USA.
RP Caspary, DM (reprint author), So Illinois Univ, Sch Med, Dept Pharmacol, POB 19629,801 N Rutledge St, Springfield, IL 62794 USA.
EM dcaspary@siumed.edu
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NR 68
TC 21
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 129
EP 140
DI 10.1016/j.heares.2004.09.011
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300013
PM 15811705
ER
PT J
AU Nourski, KV
Abbas, PJ
Miller, CA
Robinson, BK
Jeng, FC
AF Nourski, KV
Abbas, PJ
Miller, CA
Robinson, BK
Jeng, FC
TI Effects of acoustic noise on the auditory nerve compound action
potentials evoked by electric pulse trains
SO HEARING RESEARCH
LA English
DT Article
DE acoustic noise; adaptation; cochlear implant; compound action potential;
electric-acoustic stimulation; guinea pig
ID GUINEA-PIG; STIMULATION; RESPONSES; ADAPTATION
AB This study investigated the effects of acoustic noise on the auditory nerve compound action potentials in response to electric pulse trains. subjects were adult guinea pigs, implanted with a minimally invasive electrode to preserve acoustic sensitivity. Electrically evoked compound action potentials (ECAP) were recorded front the auditory nerve trunk in response to electric pulse trains both during and after the presentation of acoustic white noise.
Simultaneously presented acoustic noise produced a decrease in ECAP amplitude. The effect of the acoustic masker on the electric probe was greatest at the onset of the acoustic stimulus and it was followed by a partial recovery of the ECAP amplitude. Following, cessation of the acoustic noise, ECAP amplitude recovered over a period of approximately 100-200 ms.
The effects of the acoustic noise were more prominent at lower electric Pulse rates (interpulse intervals of 3 ms and higher). At higher pulse rates, the ECAP adaptation to the electric Pulse train alone was larger and the acoustic noise, when presented, produced little additional effect. The observed effects of noise on ECAP were the greatest at high electric stimulus levels and. for a particular electric stimulus level. at high acoustic noise levels. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA.
RP Nourski, KV (reprint author), Univ Iowa, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
EM kirill-nourski@uiowa.edu
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NR 19
TC 10
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 141
EP 153
DI 10.1016/j.heares.2004.11.001
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300014
PM 15811706
ER
PT J
AU Maeda, K
Yoshida, K
Ichimiya, I
Suzuki, M
AF Maeda, K
Yoshida, K
Ichimiya, I
Suzuki, M
TI Dexamethasone inhibits tumor necrosis factor-alpha-induced cytokine
secretion from spiral ligament fibrocytes
SO HEARING RESEARCH
LA English
DT Article
DE cell culture; enzyme-linked immunosorbent assay; intercellular adhesion
molecule-1; mice; reverse transcribed-polymerase chain reaction
ID INTERCELLULAR-ADHESION MOLECULE-1; COCHLEAR LATERAL WALL; INNER-EAR;
GLUCOCORTICOID RECEPTORS; PROINFLAMMATORY CYTOKINES; RAT COCHLEA;
INFLAMMATION; EXPRESSION; CLONING; LOCALIZATION
AB To investigate the effect of proinflammatory cytokines on spiral ligament (SL) fibrocytes and regulation of cytokines by dexamethasone (Dex), in vitro studies were performed in murine secondary cell cultures. Cultured SL fibrocytes were stimulated with tumor necrosis factor-alpha (TNF-alpha), and the secretion of various mediators was measured by enzynne-linked immunosorbent assay (ELISA) and reverse transcribed-polymerase chain reaction (RT-PCR). After stimulation with TNF-alpha, levels of keratinocyte-derived cytokine (KC), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1) were elevated in the culture supernatant, and their corresponding messenger RNAs were detected in the cultured fibrocytes. When the cultures were incubated with both TNF-alpha and Dex, the levels of KC. MCP-1. MIP-2 and IL-6 were significantly lower than those in Cultures treated with TNF-alpha alone. The data suggest that Dex suppresses the inflammatory response in SL fibrocytes. Given that SL fibrocytes play a role in cochlear fluid and ion homeostasis, glucocrticoids may suppress the cochlear malfunction caused by SL inflammation. (c) 2004 Elsevier B.V. All rights reserved.
C1 Oita Univ, Fac Med, Dept Otolaryngol, Oita 8795593, Japan.
RP Suzuki, M (reprint author), Oita Univ, Fac Med, Dept Otolaryngol, 1-1 Idaigaoka, Oita 8795593, Japan.
EM suzukim@med.oita-u.ac.jp
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NR 31
TC 29
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 154
EP 160
DI 10.1016/j.heares.2004.08.022
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300015
PM 15811707
ER
PT J
AU Washington, JL
Pitts, D
Wright, CG
Erway, LC
Davis, RR
Alagramam, K
AF Washington, JL
Pitts, D
Wright, CG
Erway, LC
Davis, RR
Alagramam, K
TI Characterization of a new allele of Ames waltzer generated by ENU
mutagenesis
SO HEARING RESEARCH
LA English
DT Article
DE deafness; hair cells; Pcdh15; mouse
ID HEARING-LOSS; ETHYLNITROSOUREA MUTAGENESIS; PROTOCADHERIN GENE;
F1-HYBRID STRAINS; MUTANT ALLELES; MUTATIONS; PCDH15; POLARITY; MICE;
DROSOPHILA
AB Mutation in the protocadherin 15 (Pcdh15) gene causes hair cell dysfunction and is associated with abnormal stereocilia development. We have characterized the first allele (Pcdh15(a nu-nmf79)) of Ames waltzer (a nu) obtained by N-ethyl-N-nitrosourea (ENU) mutaizenesis. Pcdh15(a nu-nmf19) was generated in the Neuroscience Mutagenesis Facility (NMF) at The Jackson Lab (Bar Habor, USA). Pcdh15(a nu-nmf19) mutants display circling and abnormal swimming behavior along with lack of aUditory-evoked brainsterri response at the highest intensities tested. Mutation analysis shows base substitution (A - G) in the consensus splice donor sequence linked to exon 14 resulting in the skipping of exon 14 and the splicing of exon 13-15. This results in the introduction of a stop codon in the coding sequence of exon 15 due to shift in the reading frame. The effect of nmf19 mutation is expected to be severe since the expressed Pcdh15 protein is predicted to truncate in the 5th cadherin domain. Abnormalities of cochlear hair cell stereocilia are apparent in Pcdh15(a nu-nmf19) mutants near the time of birth and by about P15 (15 days after birth) there is evidence of sensory cell degeneration. Disorganization of outer hair cell stereocilia is observed as early as P2. Inner hair cell stereocilia are also affected, but less severely than those of the outer hair cells. These results are consistent with characteristics of the mutation in the Pcdh15(a nu-nmf19) allele and the, support our previous finding that Protocadherin 15 plays an important role in hair-bundle morphogenesis. (c) 2004 Elsevier B.V. All rights reserved.
C1 Case Western Reserve Univ, Dept Otolaryngol Head & Neck Surg, Cleveland, OH 44106 USA.
Case Western Reserve Univ, Dept Pediat, Cleveland, OH 44106 USA.
Univ Texas, SW Med Ctr, Dept Otolaryngol Head & Neck Surg, Dallas, TX 75235 USA.
Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA.
NIOSH, Div Appl Res & Technol, Engn & Phys Hazards Branch, Hearing Loss Prevent Team, Cincinnati, OH 45226 USA.
RP Alagramam, K (reprint author), Case Western Reserve Univ, Dept Otolaryngol Head & Neck Surg, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM kna3@case.edu
RI Davis, Rickie/A-3186-2008
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NR 18
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 161
EP 169
DI 10.1016/j.heares.2004.09.014
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300016
PM 15811708
ER
PT J
AU Drennan, WR
Pfingst, BE
AF Drennan, WR
Pfingst, BE
TI Current-level discrimination using bipolar and monopolar electrode
configurations in cochlear implants
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 26th Midwinter Meeting of the Association-for-Research-in-Otolaryngology
CY FEB 23-27, 2003
CL Daytona Beach, FL
SP Assoc Res Otolaryngol
DE cochlear; implant; bipolar; monopolar; lntensity discrimination
ID INTENSITY DISCRIMINATION; AUDITORY-NERVE; ELECTRICAL-STIMULATION;
STIMULUS LEVEL; PSYCHOPHYSICS; EXCITATION; PATTERNS; DEGENERATION;
PERFORMANCE; STRATEGIES
AB This study examined current-level discrimination ability in listeners with cochlear implants using bipolar and monopolar electrode configurations. Current-level discrimination ability was measured as a function of electrode configuration (monopolar and bipolar), stimulation site (8 and 16) and level (5%, 15% 25%, 50% and 80% of the dynamic range). Weber fractions usually decreased with increasing level. Differences in Weber fractions between monopolar and bipolar configurations were observed for listeners with short durations of deafness (< 5 years). For these listeners, in the bipolar condition at the more-apical site 16, Weber fractions remained constant with increasing level, and the Weber fractions at low levels were smaller than in other conditions. We suggest that nerve density was better and the nerve-to-site-of-action-potential distance was smaller in these cases such that more fibers could be recruited with a unit increase in current level, leading to better current-level sensitivity. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, Ann Arbor, MI 48109 USA.
RP Drennan, WR (reprint author), Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM warddrennan@yahoo.com
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NR 33
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 170
EP 179
DI 10.1016/j.heares.2004.11.010
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300017
PM 15811709
ER
PT J
AU Valk, WL
Wit, HP
Segenhout, JM
Dijk, F
van der Want, JJL
Albers, FWJ
AF Valk, WL
Wit, HP
Segenhout, JM
Dijk, F
van der Want, JJL
Albers, FWJ
TI Morphology of the endolymphatic sac after an acute endolymphatic in the
guinea pig hydrops
SO HEARING RESEARCH
LA English
DT Article
DE endolymphatic sac; homogeneous substance; volume regulation;
endolymphatic hydrops; Meniere's disease
ID INNER-EAR; COCHLEA; VOLUME; CELLS; RAT
AB The role of the endolymphatic sac (ES) in endolymph volume homeostasis is speculative. The present study investigates changes of the ES's epithelia and luminal filling after induction of an acute endolymphatic hydrops. After microiniection of 1.1 mu l artificial endolymph into scala media of the cochlea, guinea pigs were terminated immediately (n = 6) or after different time intervals; 1/2 h (n = 3), 1 h (n = 4) and 2 h (n = 4). Inner ear specimens were processed for light and/or transmission electron microscopy. The noninjected contralateral ear served as a histological control. Correct injection was confirmed by detection of microspheres in the endolymphatic compartment after the same microinjection procedure.
In all specimens, ribosome rich cells and intraluminal macrophages appeared to be actively involved in degradation of homogeneous substance (HS) by secreting lytic enzymes and digestion, respectively. Amazingly, in our study no ES differences were found between injected and non-injected ears and no distinct changes were observed in guinea pigs terminated after different time intervals. The ES's luminal HIS was always present and often to a large extent. This is in contrast with [Hear. Res. 138, 81] dramatic changes were observed. Endolymph volume homeostasis is a complex mechanism, in which the role of HS remains obscure. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Groningen Hosp, Dept Otorhinolaryngol, NL-9700 RB Groningen, Netherlands.
RP Valk, WL (reprint author), Univ Groningen Hosp, Dept Otorhinolaryngol, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM w.l.valk@kno.azg.nl
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NR 24
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 180
EP 187
DI 10.1016/j.heares.2004.10.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300018
PM 15811710
ER
PT J
AU Phillips, DP
Hall, SE
AF Phillips, DP
Hall, SE
TI Psychophysical evidence for adaptation of central auditory processors
for interaural differences in time and level
SO HEARING RESEARCH
LA English
DT Article
DE interaural time difference; interaural level difference; selective
adaptations; psychophysics
ID SPATIAL RECEPTIVE-FIELDS; CAT INFERIOR COLLICULUS; SOUND-LOCALIZATION;
SELECTIVE ADAPTATION; SUPERIOR COLLICULUS; PROLONGED EXPOSURE; CORTEX;
SENSITIVITY; RESPONSES; NEURONS
AB Human listeners were studied for their ability to lateralize single target tones of each of two frequencies relative to midline clicks. They did so before and after exposure to adaptor tones of the same frequencies. The adaptor tones were strongly lateralized, and in opposite directions for each frequency, by either an interaural time difference (ITD, Experiment 1) or interaural level difference (ILD, Experiment 2). Following adaptation, psychometric functions for ITD (Exp. 1) and ILD (Exp. 2) were obtained for target tones for the two frequencies separately. These were found to be shifted in the direction of the fatigued side. fit the case of ILD, this was in the absence of a shift in monaural sensitivity sufficient to account for the effect. For both ITD and ILD studies, shifts in perceived laterality were induced in opposite directions at two frequencies concurrently. This effect was induced with only seconds of intermittent exposure to the adaptor tones. The fact that it could be induced at two frequencies in opposite directions at the same time, suggests (a), that these data constitute new psychophysical evidence for the frequency specificity of ITD and ILD coding in the human brain, and (b), that the effect was not due to the introduction of some response bias at the decision level of perceptual judgement. The data are interpreted in terms of a two- or three-channel opponent process model. (c) 2004 Elsevier B.V. All rights reserved.
C1 Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada.
RP Phillips, DP (reprint author), Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada.
EM dennis.phillips@dal.ca
RI Phillips, Dennis/A-6496-2011
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NR 50
TC 35
Z9 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 188
EP 199
DI 10.1016/j.heres.2004.11.001
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300019
PM 15811711
ER
PT J
AU McFadden, SL
Woo, JM
Michalak, N
Ding, DL
AF McFadden, SL
Woo, JM
Michalak, N
Ding, DL
TI Dietary vitamin C supplementation reduces noise-induced hearing loss in
guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE antioxidants; ascorbate; ascorbic acid; acoustic trauma; reactive oxygen
species; free radicals
ID ACOUSTIC TRAUMA; IMPULSE NOISE; COCHLEAR DAMAGE; LIPID-PEROXIDATION;
OXIDATIVE DAMAGE; ASCORBIC-ACID; INNER-EAR; GLUTATHIONE; EXPOSURE;
PROTECTION
AB Vitamin C (ascorbate) is a water-soluble, low molecular weight antioxidant that works in conjunction with glutathione and other cellular antioxidants, and is effective against a variety of reactive oxygen species. including superoxide and hydroxyl radicals that have been implicated in the etiology of noise-induced hearing loss (NIHL). Whereas most animals can manufacture their own vitamin C. humans and a few other mammals such as guinea pigs lack the terminal enzyme for vitamin C synthesis and must obtain it from dietary Sources. To determine if Susceptibility to NIHL Could be influenced by manipulating dietary levels of vitamin C, albino guinea pigs were raised for 35 days on a diet with normal, supplemented or deficient levels of ascorbate, then exposed to 4 kHz octave band noise at 114 dB SPL for 6 h to induce permanent threshold shifts (PTS) of the scalp-recorded auditory brainstem response. Animals that received the highest levels of dietary ascorbate developed significantly less PTS for click stimuli and 4, 8, 12, and 16 kHz tones than animals on normal and deficient diets. Outer hair cell loss was minimal in all groups after noise exposure, but permanent damage to stereocilia were observed in noise-exposed ears. The results support the hypothesis that dietary factors influence individual Susceptibility to hearing loss, and suggest that high levels of vitamin C may be beneficial in reducing susceptibility to NIHL. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Buffalo, Ctr Hearing & Deafness, Dept Commun Sci & Disorders, Buffalo, NY 14214 USA.
RP McFadden, SL (reprint author), Univ Buffalo, Ctr Hearing & Deafness, Dept Commun Sci & Disorders, 137E Cary Hall, Buffalo, NY 14214 USA.
EM mcfadden@buffalo.edu
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NR 53
TC 33
Z9 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 200
EP 208
DI 10.1016/j.heares.2004.10.011
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300020
PM 15811712
ER
PT J
AU Smittkamp, SE
Durham, D
AF Smittkamp, SE
Durham, D
TI Effect of cochlear integrity on cochlear nucleus neuron glucose
metabolism in aged adult broiler chickens
SO HEARING RESEARCH
LA English
DT Article
DE aging; auditory; chicken; 2-deoxyglucose; nucleus magnocellularis
ID STEM AUDITORY NUCLEI; HAIR CELL LOSS; RETINAL GANGLION-CELLS;
BRAIN-STEM; TONOTOPIC ORGANIZATION; NEUROTROPHIC FACTOR; AFFERENT
INFLUENCES; FREQUENCY ORGANIZATION; BREED DIFFERENCES; BASILAR PAPILLA
AB Abrupt removal of excitatory input is devastating to post-synaptic neurons in normally functioning sensory systems. Ill both mammalian and avian auditory systems, abrupt temporary or permanent experimental deafferentation stimulates a cascade of changes in central auditory structures that can result in neuron death. Effects of naturally occurring progressive deafferentation oil central auditory structure and function have not been fully described. Extensive naturally occurring cochlear damage is found in some aged chickens, despite their regenerative capacity, providing the opportunity to examine the effects of this type of deafferentation on the avian cochlear nucleus (nucleus magnocellularis, NM).
Previous evaluation of NM oxidative metabolism using cytochrome oxidase histochemistry revealed that naturally occurring cochlear damage results in down-regulated metabolism in corresponding regions of NM. It is unknown how progressive hair cell damage and loss affects NM glucose uptake. Here, NM glucose metabolism is assessed using 2-deoxyglucose uptake as a marker for metabolic activity in the presence of normal, mildly damaged, severely damaged, and totally damaged cochlear hair cells. Results indicate that while severe and total cochlear damage significantly decrease NM oxidative metabolism, only total damage results in significantly decreased NM glucose metabolism. Results are discussed in the context of functional reorganization and trophic support. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, Kansas City, KS 66160 USA.
Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66160 USA.
RP Durham, D (reprint author), Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, 3901 Rainbow Blvd,MS 3010, Kansas City, KS 66160 USA.
EM ddurham@kumc.edu
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NR 71
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 209
EP 221
DI 10.1016/j.heares.2004.10.009
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300021
PM 15811713
ER
PT J
AU Jen, PHS
Wu, CH
AF Jen, PHS
Wu, CH
TI The role of GABAergic inhibition in shaping the response size and
duration selectivity of bat inferior collicular neurons to sound pulses
in rapid sequences
SO HEARING RESEARCH
LA English
DT Article
DE bat; bicuculline; duration selectivity; inferior colliculus; GABA;
response size
ID BIG BROWN BAT; VENTRAL COCHLEAR NUCLEUS; DEPENDENT RECOVERY CYCLE;
PRIMARY AUDITORY-CORTEX; EPTESICUS-FUSCUS; SPACE REPRESENTATION;
REPETITION RATE; FM BAT; DIRECTIONAL SELECTIVITY; BICUCULLINE
APPLICATION
AB Natural sounds, Such as vocal communication sounds of many animal species typically occur as sequential sound pulses. Therefore, the response size of auditory neurons to a sound Pulse Would be inevitably affected when the sound pulse is preceded and succeeded by another Sound pulse (i.e., forward and backward masking). The present study presents data to show that increasing strength of GABAergic inhibition relative to excitation contributes to decreasing response size and sharpening of duration selectivity of bat inferior collicular (IC) neurons to Sound pulses in rapid sequences. The response size in number of impulses and duration selectivity of IC neurons were studied with a pulse train containing 9 sound pulses. A family of duration tuning curves was plotted for IC neurons using the number of impulses discharged to each presented sound pulse against pulse duration. Our data show that the response size of IC neurons progressively decreased and duration selectivity increased when determined with sequentially presented sound pulses. This variation in the response size and duration selectivity of IC neurons with sequentially presented sound pulses was abolished or reduced during bicuculline and GABA application. Bicuculline application increased the response size and broadened the duration tuning curve of IC neurons while GABA application produced opposite results. Possible mechanisms underlying increasing strength of GABAergic inhibition with sequentially presented sound pulses are presented. Biological significance of these findings in relation to acoustic signal processing is also discussed. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
Univ Missouri, Interdisciplinary Neurosci Program, Columbia, MO 65211 USA.
RP Jen, PHS (reprint author), Univ Missouri, Div Biol Sci, 208 Lefevre Hall, Columbia, MO 65211 USA.
EM jenp@missouri.edu
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NR 63
TC 17
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 222
EP 234
DI 10.1016/j.heures.2004.11.008
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300022
PM 15811714
ER
PT J
AU Li, L
Qi, JG
He, Y
Alain, C
Schneider, BA
AF Li, L
Qi, JG
He, Y
Alain, C
Schneider, BA
TI Attribute capture in the precedence effect for long-duration noise
sounds
SO HEARING RESEARCH
LA English
DT Article
DE precedence effect; fusion; reverberant environment; correlation; gap;
event-related potential
ID INFERIOR COLLICULUS; ECHO SUPPRESSION; SIMULATED ECHOES;
AUDITORY-CORTEX; DISCRIMINATION; LOCALIZATION; CAT; LATERALIZATION;
RESPONSES; BREAKDOWN
AB Listeners perceptually fuse the direct wave from a sound Source with its reflections off nearby surfaces into a single sound image, located at or near the Sound source (the precedence effect). This study investigated how a brief gap presented in the middle of either a direct wave or simulated reflection is incorporated into the fused image. For short (< 9.5 ms) delays between the direct (leading) and reflected (lagging) waves. no sound was perceived from the direction of the lagging wave. For delays between 10 and 15 ins. both Sounds were perceived. but the gap was heard only on the leading side. When the gap was only in the correlated lagging Sound at short delays, it also was perceived as occurring on the leading side. Moreover, gap detection thresholds were the same for gaps in the leading and lagging sounds. suggesting that the perception of the gap was not suppressed, but rather incorporated into the leading sound. Finally. scalp event-related potentials were not associated with the precedence effect until the gap occurred. This suggests that cortical mechanisms are engaged to maintain fusion when attributes in direct or reflected waves change. (c) 2004 Elsevier B.V. All rights reserved.
C1 Peking Univ, Natl Key Lab Machine Precept, Speech & Hearing Res Ctr, Dept Psychol, Beijing 100871, Peoples R China.
Univ Toronto, Dept Psychol, Ctr Res Biol Commun Syst, Mississauga, ON L5L 1C6, Canada.
Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON M6A 2E1, Canada.
RP Li, L (reprint author), Peking Univ, Natl Key Lab Machine Precept, Speech & Hearing Res Ctr, Dept Psychol, Beijing 100871, Peoples R China.
EM liang@psych.utoronto.ca
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NR 32
TC 25
Z9 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 235
EP 247
DI 10.1016/j.heures.2004.10.007
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300023
PM 15811715
ER
PT J
AU Schmerber, S
Sheykholeslami, K
Kermany, MH
Hotta, S
Kaga, K
AF Schmerber, S
Sheykholeslami, K
Kermany, MH
Hotta, S
Kaga, K
TI Time-intensity trading in bilateral congenital aural atresia patients
SO HEARING RESEARCH
LA English
DT Article
DE bone conduction; sound lateralization; binaural processing; plasticity;
auditory cues; human
ID SUPERIOR OLIVARY COMPLEX; ANCHORED HEARING-AID; INTERAURAL TIME;
AUDITORY LOCALIZATION; SOUND LOCALIZATION; BRAIN-STEM; BARN OWL;
PHYSIOLOGICAL-MECHANISMS; LATERALIZATION; BONE
AB In an effort to examine the rules by which information of bilaterally applied bone-conducted signals arising from interaural time differences (ITD) and interaural intensity differences (IID) is combined, data were measured for continuous 500 Hz narrow band noise at 65-70 dB HL in 11 patients with bilateral congenital aural atresia. Time-intensity trading functions were obtained by shifting the sound image towards one side using ITD, and shifting back to a centered sound image by varying the IID in the same ear (auditory midline task). ITD values were varied from -600 to +600 ps at 200 ps steps, where negative values indicate delays to the right ear. The results indicate that time-intensity trading is present in patients with bilateral aural atresia. The gross response properties of time-intensity trading in response to bone-conducted signals were comparable in patients with bilateral aural atresia and normal-hearing Subjects, though there was a larger inter-subject variability and higher discrimination thresholds across IlDs in the atresia group. These results suggest that the mature auditory brainstem has a potential to employ binaural cues later in life, although to a restricted degree. A binaural fitting of a bone-conducted hearing aid might optimize binaural hearing and improve sound lateralization, and we recommend now systematically bilateral fitting in aural atresia patients. (c) 2004 Elsevier B.V. All rights reserved.
C1 CHU Grenoble, Serv ORL, Univ Hosp, Dept Otolaryngol, F-38043 Grenoble, France.
Univ Tokyo, Grad Sch Med, Dept Otolaryngol, Tokyo, Japan.
RP Schmerber, S (reprint author), CHU Grenoble, Serv ORL, Univ Hosp, Dept Otolaryngol, BP 217, F-38043 Grenoble, France.
EM sschmerber@chu-greuoble.fr
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NR 51
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 248
EP 257
DI 10.1016/j.heures.2004.11.012
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300024
PM 15811716
ER
PT J
AU Leshinsky-Silver, E
Berman, Z
Vinkler, C
Yannov-Sharav, M
Lev, D
AF Leshinsky-Silver, E
Berman, Z
Vinkler, C
Yannov-Sharav, M
Lev, D
TI A novel missense mutation in the Connexin 26 gene associated with
autosomal recessive sensorineural deafness
SO HEARING RESEARCH
LA English
DT Article
DE Connexin 26; sensorineural deafness; mutation
ID HEARING-LOSS
AB Mutations in the Connexin 26 (Cx26) gene (GJB2) are a common cause of hereditary hearing impairment. We report the identification of a novel point mutation in the Cx26 gene, Leu205Pro(L205P), linked to familial, autosomal recessive sensorineural hearing loss. This missense mutation, causing amino acid leucine at position 205 to be substituted by proline, is located in the highly conserved sequence of the fourth transmembrane domain (TM4) of Cx26. Hearing loss with this mutation occurred in a Georgian Jewish family, was congenital, moderate to profound and nonprogressive. We have shown that the new mutation L205P in Cx26 is strongly associated with congenital NSHL. Multiple-sample screening for this mutation can be easily performed with a mismatch PCR that creates a restriction site. (c) 2004 Elsevier B.V. All rights reserved.
C1 Wolfson Med Ctr, Mol Genet Lab, IL-58100 Holon, Israel.
Wolfson Med Ctr, Genet Inst, IL-58100 Holon, Israel.
RP Leshinsky-Silver, E (reprint author), Wolfson Med Ctr, Mol Genet Lab, POB 5, IL-58100 Holon, Israel.
EM leshinsky@wolfson.health.gov.il
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NR 11
TC 4
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD APR
PY 2005
VL 202
IS 1-2
BP 258
EP 261
DI 10.1016/j.heares.2004.11.003
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 919JM
UT WOS:000228614300025
PM 15811717
ER
PT J
AU Yarin, YM
Amarjargal, N
Fuchs, J
Haupt, H
Mazurek, B
Morozova, SV
Gross, J
AF Yarin, YM
Amarjargal, N
Fuchs, J
Haupt, H
Mazurek, B
Morozova, SV
Gross, J
TI Argon protects hypoxia-, cisplatin- and gentamycin-exposed hair cells in
the newborn rat's organ of Corti
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 41st Inner Ear Biology Workshop
CY SEP 05-07, 2004
CL Debrecen, HUNGARY
DE argon; cisplatin; gentamycin; hair cells; hypoxia; ototoxicity
ID SUDDEN HEARING-LOSS; GUINEA-PIG COCHLEA; NOBLE-GASES; TRANSMITTER
RELEASE; INDUCED APOPTOSIS; MOUSE COCHLEA; CA2+ CHANNELS; IN-VITRO;
XENON; DEATH
AB During the last few years, an important protective effect of the noble gas xenon against neuronal hypoxic damage was observed. However, argon (Ar), a gas from the same chemical group, but less expensive and without anesthetic effect at normobaric pressure, has not been studied in terms of possible biological effects on cell protection.
Ar was tested for its ability to protect organotypic cultures of the organ of Corti from 3-5 day old rats against hypoxia, cisplatin, and gentamycin toxicity. Cultures were exposed to nitrogen hypoxia (5%, CO2, 95% N-2), Ar hypoxia (5% CO2, 95% Ar) or normoxia for 30 h. Ar protected the hair cells from hypoxia-induced damage by about 25%. Ar oxygen (O-2) mixtures (21% O-2, 5% CO2, 74% Ar) had no effect on the hair cell survival. Cisplatin (7.5-25 mu M) and gentamycin (5-40 mu M) exposed in medium under air damaged the hair cells in a dose-dependent manner. The exposure of cisplatin- and gentamycin-treated cultures to the Ar-O-2 atmosphere significantly reduced the hair cell damage by up to 25%. This protective effect of Ar might provide a new protective approach against ototoxic processes. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Med Berlin, Charite, Dept Otolaryngol, Mol Biol Res Lab, D-14050 Berlin, Germany.
Tech Univ Dresden, Dept Otorhinolaryngol, D-8027 Dresden, Germany.
Hlth Sci Univ, Matern & Child Hlth Res Ctr, Pediat Clin, Dept Hearing Res, Ulaanbaatar, Mongol Peo Rep.
IM Sechenov Moscow Acad Med, Dept Otorhinolaryngol, Moscow, Russia.
RP Gross, J (reprint author), Univ Med Berlin, Charite, Dept Otolaryngol, Mol Biol Res Lab, Spandauer Damn 130,Bldg 31, D-14050 Berlin, Germany.
EM johann.gross@charite.de
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NR 55
TC 18
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
EI 1878-5891
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2004.09.015
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200001
PM 15721555
ER
PT J
AU Roman, S
Canevet, G
Marquis, P
Triglia, JM
Liegeois-Chauvel, C
AF Roman, S
Canevet, G
Marquis, P
Triglia, JM
Liegeois-Chauvel, C
TI Relationship between auditory perception skills and mismatch negativity
recorded in free field in cochlear-implant users
SO HEARING RESEARCH
LA English
DT Article
DE mismatch negativity; cochlear implant; frequency discrimination;
detection thresholds; word discrimination
ID SPEECH RECOGNITION; EVOKED-RESPONSES; DISCRIMINATION; PERFORMANCE;
POTENTIALS; COMPONENTS; STIMULI; RANGE
AB This study investigated the ability of cochlear-implanted patients to discriminate tone bursts in free field using the electrophysiological recordings of mismatch negativity (MMN). Seven cochlear-implanted patients (CIP) and eight control subjects (CS) were tested. Event-related potentials were recorded from either 32 or 64 electrodes in response to binaural stimuli using a passive oddball paradigm. Two stimulus-contrast conditions were used to produce MMN: The standard-tone frequency was fixed at 1 kHz, and the deviant-tone frequency was set at 2 or 1.5 kHz. The results show that response waveforms (N-1/P-2) are similar in latency and amplitude for CS and CIP, suggesting that pure-tone detection is performed over the same time window in both groups. These waveforms are also similar in left- and right-implanted patients, suggesting that electric stimulation of the auditory nerve activates both hemispheres in profound, bilateral hearing loss. Pure-tone audiograms and word-discrimination scores were also measured in each subject in an anechoic room and their relations with MMN data were examined. Correlations were found between the latency of MMN for a 1.5 kHz deviant and the thresholds obtained for pure-tone detection and word discrimination. MMN appears as a possible complementary clinical toot to objectively assess auditory sensitivity in cochlear-implanted populations. However, further improvements are still necessary before it can be used as a standard clinical examination. (c) 2004 Elsevier B.V. All rights reserved.
C1 CHU Timone, Lab Audiophonol Clin, F-13385 Marseille, France.
CNRS, Lab Mecan & Acoust, F-13402 Marseille, France.
Fac Med Marseille, INSERM, Lab Neurophysiol & Neuropsychol, F-13385 Marseille, France.
RP Roman, S (reprint author), CHU Timone, Lab Audiophonol Clin, Rue St Pierre, F-13385 Marseille, France.
EM stephane.roman@mail.ap-hm.fr
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NR 31
TC 19
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 10
EP 20
DI 10.1016/j.heares.2004.08.021
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200002
PM 15721556
ER
PT J
AU Toyama, K
Ozeki, M
Hamajima, Y
Lin, JZ
AF Toyama, K
Ozeki, M
Hamajima, Y
Lin, JZ
TI Expression of the integrin genes in the developing cochlea of rats
SO HEARING RESEARCH
LA English
DT Article
DE integrins; cochlear development; microarrays; NF-kappa B; Sprague-Dawley
rats
ID FIBROBLAST-GROWTH-FACTOR; INNER-EAR; CELL-ADHESION;
EXTRACELLULAR-MATRIX; IDENTIFICATION; PROLIFERATION; ACTIVATION;
PATHWAY; ORGAN; CORTI
AB Integrins play an important role in the development of the cochlea. However, little is known about the expression pattern of integrins in-the developing cochlear tissue. In this Study, we investigated the dynamic expression profile of the integrin genes in the developing cochlear tissue of rats by Affymetrix microarrays and explored the role of the integrin genes in vitro by using antisense oligonucleotides. It was demonstrated that the alpha 1, alpha 7, alpha v, beta 3, and beta 4 genes were expressed in the developing cochlear tissue of rats. Inhibition of the integrin expression with antisense oligonucleotides against alpha v, alpha 7, beta 3, and beta 4, respectively, in cochlear sensorineural epithelial cells significantly decreased the [H-3]thymidine incorporation, suggesting that these integrins are involved in cell growth and proliferation. Inhibition of the alpha v and beta 4 integrins significantly decreased the transcription of nuclear factor-kappa B (NF-kappa B, a signal molecule involved in cell growth and proliferation) induced by epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), respectively. It suggests that EGF-induced cell growth is dependent upon the alpha v integrin whereas bFGF-induced cell growth is dependent upon the beta 4 integrin in the cochlear tissue during the development of the inner ear. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Minnesota, Sch Med, Dept Otolaryngol, Auditory Mol Biol Lab, Minneapolis, MN 55455 USA.
RP Lin, JZ (reprint author), Univ Minnesota, Sch Med, Dept Otolaryngol, Auditory Mol Biol Lab, Minneapolis, MN 55455 USA.
EM linxx004@umn.edu
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NR 29
TC 11
Z9 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 21
EP 26
DI 10.1016/j.heares.2004.04.019
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200003
PM 15721557
ER
PT J
AU Wysocki, LE
Ladich, F
AF Wysocki, LE
Ladich, F
TI Effects of noise exposure on click detection and the temporal resolution
ability of the goldfish auditory system
SO HEARING RESEARCH
LA English
DT Article
DE auditory evoked potentials; auditory temporal resolution; noise
exposure; temporal hearing loss
ID BRAIN-STEM RESPONSES; INDUCED HEARING-LOSS; CARASSIUS-AURATUS; ACOUSTIC
COMMUNICATION; UNDERWATER NOISE; FISH; SOUNDS; BEHAVIOR; DISCRIMINATION;
SENSITIVITY
AB Hearing specialist fishes investigated so far revealed excellent temporal resolution abilities, enabling them to accurately process temporal patterns of sounds. Because noise is a growing environmental problem, we investigated how it affects the temporal resolution ability of goldfish. Auditory evoked potentials (AEPs) in response to clicks and double clicks were recorded before exposing, immediately after exposing the fish to white noise of 158 dB re 1 mu Pa for 24 h, and after 3, 7 and 14 days of recovery. Immediately after noise exposure, hearing sensitivity to clicks was reduced on average by 21 dB and recovered within 1 week. Amplitudes of the AEPs decreased by about 71% while latencies increased by 0.63 ins. Both AEP characteristics returned to baseline values within 2 weeks. Analysis of the response to double clicks showed that the minimum click period resolvable by the auditory system increased significantly from 1.25 to 2.08 ms immediately after noise exposure. After a recovery period of 3 days, this minimum period returned to pre-exposure values. The present study revealed that noise exposure affects the detection of short transient signals and the temporal resolution ability. Because acoustic information is primarily encoded via temporal patterns of sounds in fishes, environmental noise could severely impair acoustic orientation and communication. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Vienna, Inst Zool, A-1090 Vienna, Austria.
RP Wysocki, LE (reprint author), Univ Vienna, Inst Zool, Althanstr 14, A-1090 Vienna, Austria.
EM Lidia.Wysocki@univie.ac.at
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NR 58
TC 29
Z9 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 27
EP 36
DI 10.1016/j.heares.2004.08.015
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200004
PM 15721558
ER
PT J
AU Avallone, B
Fascio, U
Senatore, A
Balsamo, G
Bianco, PG
Marmo, F
AF Avallone, B
Fascio, U
Senatore, A
Balsamo, G
Bianco, PG
Marmo, F
TI The membranous labyrinth during larval development in lamprey (Lampetra
planeri, Bloch, 1784)
SO HEARING RESEARCH
LA English
DT Article
DE Lampetra planeri; brook lamprey; membranous labyrinth; hair cells;
Macula communis; ciliated chamber
ID ULTRASTRUCTURE; ANATOMY; EAR
AB SEM and CLSM studies were performed on the membranous labyrinth of Lampetra planeri, a threatened species of brook lamprey, spanning from the 1st to the 4th year of ammocoetes larval stages and on the adults. In all the examined stages, the entire membranous labyrinth does not show any morphologic differences, but only a progressive increase in size. SEM and CLSM observations show that the ciliated chamber is lined with numerous unsensorial multiciliated cells. In the early stages, the ciliary bundles were approximately 15 mu m long, while in the late stages they reached 30 mu m. In the crista sensory area, we observed two populations of hair cells. "Type II" cells are peculiar for this species and show both long stereocilia decreasing in length and a long kinocilium (10-12 mu m). Two other types of ciliary bundles have been found on the sensory hair cells of the Macula communis: the first one has both kinocilium and stereocilia about 4-5 mu m long; the second shows a long kinocilium (7-10 mu m in length) and short stereocilia bundles with a gradual increase in length. In the early stages of development, the three macular areas show few and sparsely distributed hair cells. In the late developmental stages, hair cells become more numerous and densely populated. (c) 2004 Published by Elsevier B.V.
C1 Univ Naples Federico II, Dept Genet Gen & Mol Biol, Naples, Italy.
Univ Milan, CIMA, I-20122 Milan, Italy.
Univ Naples Federico II, Dept Zool, Naples, Italy.
RP Marmo, F (reprint author), Univ Naples Federico II, Dept Genet Gen & Mol Biol, Naples, Italy.
EM Avallone@biol.dgbm.unina.it; marmo@biol.dgbm.unina.it
CR Avallone B, 2003, HEARING RES, V178, P79, DOI 10.1016/S0378-5955(03)00040-6
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NR 18
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 37
EP 43
DI 10.1016/j.heares.2004.09.002
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200005
PM 15721559
ER
PT J
AU Williams, EJ
Bacon, SP
AF Williams, EJ
Bacon, SP
TI Compression estimates using behavioral and otoacoustic emission measures
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT Annual Convention of the American-Speech-Language-Hearing-Association
CY NOV 13-15, 2003
CL Chicago, IL
SP Amer Speech Language Hearing Assoc
DE compression; distortion product otoacoustic emissions; forward masking
ID BASILAR-MEMBRANE NONLINEARITY; INPUT-OUTPUT FUNCTIONS; GUINEA-PIG
COCHLEA; NORMAL-HEARING; CHINCHILLA COCHLEA; PERIPHERAL COMPRESSION;
AUDITORY COMPRESSION; MOSSBAUER TECHNIQUE; GROWTH-BEHAVIOR; IN-VIVO
AB Cochlear compression in normal-hearing listeners was estimated at octave frequencies from 250 to 4000 Hz using a forward-masking paradigm. Temporal masking curves (TMCs) for a 10-dB SL signal were obtained with two maskers - one equal in frequency to the signal and another an octave below the signal. The ratio of the slope of the off-frequency function to that of the mid-level portion of the on-frequency function was computed as an estimate of the amount of compression at each frequency. Compression was less frequency selective at low frequencies, so an average of the off-frequency slopes at high frequencies (1000, 2000, and 4000 Hz) was used in computing the ratio for each signal frequency. Results indicated strong compression (similar to 0.15-0.30) at all frequencies using the averaged off-frequency slopes, indicating little difference in compression across frequencies. Distortion product otoacoustic emission (DPOAE) input-output (I-O) functions were obtained for each subject at 1000, 2000, and 4000 Hz. The slopes of the DPOAE I-O functions and the psychophysical growth rates were similar to one another, reinforcing the assumption that the forward-masking procedure is providing an estimate of cochlear compression, at least at frequencies from 1000 to 4000 Hz. (c) 2004 Elsevier B.V. All rights reserved.
C1 Arizona State Univ, Dept Speech & Hearing Sci, Psychoacoust Lab, Tempe, AZ 85287 USA.
RP Bacon, SP (reprint author), Arizona State Univ, Dept Speech & Hearing Sci, Psychoacoust Lab, POB 870102, Tempe, AZ 85287 USA.
EM spb@asu.edu
CR American National Standards Institute (ANSI), 1996, S361996 ANSI
Bacon Sid P., 2004, VVolume 17, P1
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NR 41
TC 22
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 44
EP 54
DI 10.1016/j.heares.2004.10.006
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200006
PM 15721560
ER
PT J
AU Lychakov, DV
Rebane, YT
AF Lychakov, DV
Rebane, YT
TI Fish otolith mass asymmetry: morphometry and influence on acoustic
functionality
SO HEARING RESEARCH
LA English
DT Article
DE otolith mass asymmetry; fish; sacculus; utriculus; lagena; otolith
growth fluctuation model; sensitivity; time resolution; directional
detection
ID INNER-EAR; HAIR CELL; EVOLUTION; APPARATUS
AB The role of the fish otolith mass asymmetry in acoustic functionality is studied. The saccular, lagenar and utricular otoliths are weighted in two species of the Black Sea rays, 15 species of the Black Sea teleost fish and guppy fish. The dimensionless otolith mass asymmetry chi is calculated as ratio of the difference between masses of the right and left paired otoliths to average otolith mass.
In the most fish studied the otolith mass asymmetry is within the range of -0.2 < chi < + 0.2 (< 20%). We do not find specific fish species with extremely large or extremely small otolith asymmetry. The large otoliths do not belong solely to any particular side, left or right. The heavier otoliths of different otolithic organs can be located in different labyrinths. No relationship has been found between the magnitude of the otolith mass asymmetry and the length (mass, age) of the animal. The suggested fluctuation model of the otolith growth can interpret these results. The model Supposes that the otolith growth rate varies slightly hither and thither during lifetime of the individual fish. Therefore, the sign of the relative otolith mass asymmetry can change several times in the process of the individual fish growth but within the range outlined above.
Mathematical modeling shows that acoustic functionality (sensitivity, temporal processing, sound localization) of the fish can be disturbed by the otolith mass asymmetry. But this is valid only for the fish with largest otolith masses, characteristic of the bottom and littoral fish, and with highest otolith asymmetry. For most fish the values of otolith mass asymmetry is well below critical values. Thus, the most fish get around the troubles related to the otolith mass asymmetry. We suggest that a specific physicochemical mechanism of the paired otolith growth that maintains the otolith mass asymmetry at the lowest possible level should exist. However, the principle and details of this mechanism are still far from being understood. (c) 2004 Elsevier B.V. All rights reserved.
C1 Russian Acad Sci, IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg 194223, Russia.
Russian Acad Sci, Ioffe Phys Tech Inst, St Petersburg 194021, Russia.
RP Lychakov, DV (reprint author), Russian Acad Sci, IM Sechenov Evolutionary Physiol & Biochem Inst, Thorez Pr 44, St Petersburg 194223, Russia.
EM Lychakov@ieplib.ru
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NR 47
TC 20
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 55
EP 69
DI 10.1016/j.heares.2004.08.017
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200007
PM 15721561
ER
PT J
AU Shaikh, AG
Finlayson, PG
AF Shaikh, AG
Finlayson, PG
TI Excitability of auditory brainstem neurons, in vivo, is increased by
cyclic-AMP
SO HEARING RESEARCH
LA English
DT Article
ID DORSAL COCHLEAR NUCLEUS; SPONTANEOUS NEURAL ACTIVITY; UNIQUE DITERPENE
ACTIVATOR; INTENSE SOUND EXPOSURE; EAR OSSICLE REMOVAL; PROTEIN-KINASE;
UNILATERAL COCHLEAR; ACOUSTIC TRAUMA; CATION CURRENT; INFERIOR
COLLICULUS
AB Physiological control of auditory neural responses is critical for accurate representation of acoustic information, such as Sound source localization and speech perception. Central auditory neural responses are almost certainly regulated by a range of mechanisms, including second messenger systems, such as the cAMP pathway. An increase in spontaneous neural discharge is known to accompany cochlear insults. Here we report that an increase in spontaneous as well as tone-evoked discharge can also be induced by pressure application of forskolin, a pharmacological agent that elevates intracellular cAMP level by activating adenyl cyclase. The forskolin induced increase in superior olivary complex (SOC) brainstem neurons is specific, dose-dependent, and reversible, whereas application of artificial cerebrospinal fluid (aCSF, the vehicle) does not alter activity. Forskolin-application also has a relatively greater effect on spontaneous activity compared to tone evoked responses. Blockade of the hyperpolarization-activated current, I-h, by ZD7288, consistently reversed the effects of forskolin. Based on these findings, we propose that the second messenger, cAMP, can significantly modulate neural excitability and spontaneous discharge in SOC neurons, principally by shifting the activation of I-h channels. (c) 2004 Elsevier B.V. All rights reserved.
C1 Wayne State Univ, Sch Med, Dept Otolaryngol, Detroit, MI 48201 USA.
RP Shaikh, AG (reprint author), Wayne State Univ, Sch Med, Dept Otolaryngol, Detroit, MI 48201 USA.
EM ashaikh@med.wayne.edu
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NR 73
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 70
EP 80
DI 10.1016/j.heares.2004.10.005
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200008
PM 15721562
ER
PT J
AU Lynch, ED
Gu, RD
Pierce, C
Kil, J
AF Lynch, ED
Gu, RD
Pierce, C
Kil, J
TI Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by
oral administration of allopurinol and ebselen
SO HEARING RESEARCH
LA English
DT Article
DE chemoprotection; ototoxicity; nephrotoxicity; allopurinol; ebselen
ID BLIND CLINICAL-TRIAL; PHASE-II; SUPEROXIDE-DISMUTASE; ANTIOXIDANT
SYSTEM; PROTECTIVE AGENTS; COCHLEAR DAMAGE; CIS-PLATINUM; HEARING-LOSS;
GUINEA-PIG; NOISE
AB Cisplatin ototoxicity has been associated with the generation of toxic levels of reactive oxygen species (ROS) which can lead to injury or loss of outer hair cells in the organ of Corti, damage to the stria vascularis, and loss of spiral ganglion cells, resulting in permanent hearing loss. In an attempt to reduce the formation of ROS and to bolster the innate oxidative stress defenses of the cochlea, we tested individual and combined formulations of allopurinol, a xanthine oxidase inhibitor, and ebselen, a glutathione peroxidase mimic. We used an acute cisplatin toxicity rat model (16 mg/kg i.p.) to analyze allopurinol and ebselen alone and in combination for their ability to reduce cisplatin associated hearing loss and nephrotoxicity. The results from our studies indicate that a combined formulation of ebselen and allopurinol affords significant protection to the cochlea and kidney from cisplatin toxicity. In the cochlea, protection is dependent on the preservation of outer hair cell number, while in the kidney, protection is associated with the preservation of proximal tubular epithelia. Further evaluation of the chemoprotective effects of ebselen and allopurinol on cisplatin side effects in the presence of tumor appears warranted. (c) 2004 Elsevier B.V. All rights reserved.
C1 Sound Pharmaceut Inc, Res & Dev, Seattle, WA 98103 USA.
RP Lynch, ED (reprint author), Sound Pharmaceut Inc, Res & Dev, 4010 Stone Way N,Suite 120, Seattle, WA 98103 USA.
EM elynch@soundpharmaceuticals.com
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NR 33
TC 50
Z9 58
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 81
EP 89
DI 10.1016/j.heares.2004.08.002
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200009
PM 15721563
ER
PT J
AU Emmerich, E
Richter, F
Linss, V
Linss, W
AF Emmerich, E
Richter, F
Linss, V
Linss, W
TI Frequency-specific cochlear damage in guinea pig after exposure to
different types of realistic industrial noise
SO HEARING RESEARCH
LA English
DT Article
DE DPOAE; outer hair cell; industrial noise exposure; scanning electron
microscopy; hearing loss; guinea pig
ID PRODUCT OTOACOUSTIC EMISSIONS; HAIR CELL LOSS; INDUCED HEARING-LOSS;
IMPULSE NOISE; THRESHOLD SHIFTS; CHINCHILLA; RESPONSES; DPOAE; EARS;
INTERMITTENT
AB For the causal evaluation of occupational hearing damage it is important to identify definitely the noise source. Here we tested, whether recordings of distortion product otoacoustic emissions (DPOAEs) in awake guinea pigs can distinguish the effects of different industrial noises. Six groups of 12 animals each were investigated before and over four months after a single 2 h exposure to specific, played-back industrial noise as well as before and for 2 months after impulse noise exposure. We compared broadband noise (buzz saw, bottle washing machine), low frequency noise (drawing press), and mid-frequency noise (bottle filling machine). All animals had stable DPOAE levels before noise exposure. Frequency specific decreases in DPOAEs were found after exposure to the different noises. Broadband noise diminished mostly all frequencies tested.. whereas low- or mid-frequency noise had a greater effect on DPOAE evoked by middle and higher frequencies, respectively. DPOAE evoked by middle and higher frequencies were obliterated after impulse noise. Morphological analysis of the cochleae confirmed these alterations. OHC loss was found in the middle turns of the cochleae corresponding to the diminution of DPOAE. We conclude that different kinds of industrial noise tend to produce typical changes in DPOAE levels. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Jena, Inst Physiol Neurophysiol, D-07740 Jena, Germany.
Univ Jena, Inst Anat 1, D-07740 Jena, Germany.
RP Emmerich, E (reprint author), Univ Jena, Inst Physiol Neurophysiol, Teichgraben 8, D-07740 Jena, Germany.
EM EEMM@mti.uni-jena.de; fric@mti.uni-jena.de
CR AVAN P, 2001, NOISE HLTH, V3, P1
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NR 36
TC 10
Z9 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 90
EP 98
DI 10.1016/j.heares.2004.09.009
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200010
PM 15721564
ER
PT J
AU Halsey, K
Skjonsberg, A
Ulfendahl, M
Dolan, DF
AF Halsey, K
Skjonsberg, A
Ulfendahl, M
Dolan, DF
TI Efferent-mediated adaptation of the DPOAE as a predictor of
aminoglycoside toxicity
SO HEARING RESEARCH
LA English
DT Article
DE hearing; gender; aminoglycoside; efferent; adaptation; DPOAE
ID PRODUCT OTOACOUSTIC EMISSION; OUTER HAIR-CELLS; GUINEA-PIG;
ALKALINE-PHOSPHATASE; GENTAMICIN BLOCKS; OTOTOXICITY; RECEPTOR;
SUSCEPTIBILITY; ACTIVATION; SLOW
AB Rapid efferent adaptation of the distortion product otoacoustic emission (DPOAE) predicts susceptibility to noise-induced damage, and is linked to the concentration of the efferent receptor (alpha 9). Maximum adaptation occurs at intense primary levels, rapidly switching from positive to negative orientation in a very narrow (2 dB) range of F-1 and F-2 levels.
Aminoglycosides are commonly used antibiotics, with the undesirable side-effect of ototoxicity. Susceptibility to hair cell damage from the aminoglycoside gentamicin can be quite variable, even within a single strain and species of animal. Since one of gentamicin's first sites of action in the outer hair cell (OHC) is at the efferent receptor, it is possible that efferent activity could be a predictor of susceptibility to gentamicin induced damage.
Significant sex-related differences were found in two strains of guinea pigs when treated with gentamicin. Female guinea pigs were more susceptible both to systemic effects and to specific ototoxic effects.
Efferent-mediated DPOAE adaptation served as a predictor of sensitivity to aminoglycoside damage, predicting both number of days before onset of deafness in male animals, and predicting final threshold shifts from gentamicin doses which produced variable results. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, Ann Arbor, MI 48109 USA.
Karolinska Inst, Ctr Hearing & Commun Res, SE-17176 Stockholm, Sweden.
Karolinska Inst, Dept Otolaryngol, SE-17176 Stockholm, Sweden.
RP Dolan, DF (reprint author), Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM ddolan@umich.edu
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NR 22
TC 17
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 99
EP 108
DI 10.1016/j.heares.2004.09.010
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200011
PM 15721565
ER
PT J
AU Lichtenhan, JT
Chertoff, ME
Smittkamp, SE
Durham, D
Girod, DA
AF Lichtenhan, JT
Chertoff, ME
Smittkamp, SE
Durham, D
Girod, DA
TI Predicting severity of cochlear hair cell damage in adult chickens using
DPOAE input-output functions
SO HEARING RESEARCH
LA English
DT Article
DE distortion product otoacoustic emissions; binary logistic regression;
auditory; avian
ID PRODUCT OTOACOUSTIC EMISSIONS; ACOUSTIC DISTORTION PRODUCTS;
EVOKED-POTENTIAL THRESHOLDS; INTERRUPTED NOISE EXPOSURES; AUDITORY
BRAIN-STEM; HYALINE CELLS; NUCLEUS NEURONS; BREED DIFFERENCES;
DEAFFERENTATION; REGENERATION
AB Distortion product otoacoustic emissions (DPOAE) were recorded from the ear canal of aged broiler chickens which have been shown to present with age-related cochlear degeneration [Hear. Res. 166 (2002) 82]. We describe the relationship between the shape of the DPOAE input-output (I/O) function and the type of hair cell damage present at and between the cochlear frequency places of the DPOAE primary tones (f(1) and f(2)). The mid stimulus level compressive growth of the mean DPOAE I/O functions is reduced in a graded fashion relative to the severity of hair cell damage. However, individual DPOAE I/O functions within most hair cell damage groups show large variability from this characteristic. Various least squares regression models were used to predict hair cell density from indices derived from the DPOAE I/O function (area, threshold and slope). The results showed that no simple linear relationship exists between hair cell density and the DPOAE I/O function indices. multivariate binary logistic regression used DPOAE I/O function indices to predict membership in hair cell damage groups. The logistic model revealed that DPOAE threshold can be used to predict the occurrence of severe/total hair cell damage with good specificity though poor sensitivity. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, Kansas City, KS 66160 USA.
Univ Kansas, Med Ctr, Dept Speech & Hearing, Kansas City, KS 66160 USA.
RP Durham, D (reprint author), Univ Kansas, Med Ctr, Dept Otolaryngol Head & Neck Surg, 3901 Rainbow Blvd, Kansas City, KS 66160 USA.
EM ddurham@kunic.edu
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NR 54
TC 4
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 109
EP 120
DI 10.1016/j.heares.2004.09.001
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200012
PM 15721566
ER
PT J
AU Bauer, CA
Brozoski, TJ
AF Bauer, CA
Brozoski, TJ
TI Cochlear structure and function after round window application of
ototoxins
SO HEARING RESEARCH
LA English
DT Article
DE ototoxin; cochlea; carboplatin; cisplatin; chinchilla
ID HAIR CELL LOSS; CIS-DIAMMINEDICHLOROPLATINUM; HEARING-LOSS; GUINEA-PIG;
CISPLATIN; INNER; CARBOPLATIN; CHINCHILLAS; TINNITUS; DEGENERATION
AB Topical round window application of ototoxic agents has been a useful method for studying ototoxicity and hearing loss in the mammalian cochlea. For example, species-specific differences in cochlear susceptibility to damage have been documented using this technique. Carboplatin has been characterized in the literature as a selective inner hair cell (IHC) toxin in chinchillas, while cisplatin has been characterized as a selective outer hair cell (OHC) toxin. The present experiment quantified dose-dependent damage to cochlear hair cells in the chinchilla after a single direct round window application of either cisplatin or carboplatin. Detailed cyto-cochleograms were obtained for the entire cochlear duct, for a range of doses, along with auditory brainstem response thresholds. In agreement with the literature, although there was variability, at the lowest concentrations tested (2 and 3 mg/ml), carboplatin produced Substantial IHC damage with no OHC damage. In contrast, the effects of cisplatin were more variable, and contrary to published reports, across the range of doses producing OHC damage, IHC damage was always observed. Limitations of direct round window ototoxin treatments are discussed, in addition to their potential application in the study of tinnitus. (c) 2004 Elsevier B.V. All rights reserved.
C1 So Illinois Univ, Sch Med, Div Otolaryngol, Springfield, IL 62794 USA.
RP Bauer, CA (reprint author), So Illinois Univ, Sch Med, Div Otolaryngol, POB 19662, Springfield, IL 62794 USA.
EM cbauer@siumed.edu
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NR 19
TC 16
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 121
EP 131
DI 10.1016/j.heares.2004.09.008
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200013
PM 15721567
ER
PT J
AU Kitahara, T
Li, HS
Balaban, CD
AF Kitahara, T
Li, HS
Balaban, CD
TI Changes in transient receptor potential cation channel superfamily V
(TRPV) mRNA expression in the mouse inner ear ganglia after kanamycin
challenge
SO HEARING RESEARCH
LA English
DT Article
DE transient receptor potential cation channel subfamily V (TRPV);
vanilloid receptors; kanamycin; dihydroxybenzoate; innerear; real-time
PCR
ID RAT DORSAL-ROOT; FREE-RADICAL FORMATION; NERVE GROWTH-FACTOR; HAIR CELL
LOSS; NEUROTROPHIC FACTOR; AMINOGLYCOSIDE OTOTOXICITY;
CAPSAICIN-RECEPTOR; SENSORY NEURONS; COCHLEAR NERVE; DRG NEURONS
AB The transient receptor potential cation channel subfamily V (TRPV) is a non-specific cation ion channel receptor family that is gated by heat, protons, low extracellular osmolarity and arachidonic acid derivatives. Since some of these endogenous agonists of TRPV receptors are reactive oxygen intermediates produced by lipoxygenases, it has been hypothesized that some members of the TRPV family may respond to challenges by reactive oxygen species. This study used real-time PCR to quantitatively track changes in TRPV1-4 mRNA expression in the spiral, vestibular, and trigeminal ganglia and the kidney from kanamycin (KM)-treated mice. TRPV1, TRPV2, TRPV3 and TRPV4 mRNAs were expressed in spiral and vestibular ganglia, and TRPV2 and TRPV1 mRNAs were most predominant in control mice. After KM (700 mg/kg s.c. b.i.d., 14 days), TRPV1 mRNA and protein expression were significantly up-regulated both in the spiral and vestibular ganglia, but expression was unaffected in the trigeminal ganglion and kidney. Real-time PCR also demonstrated a significant down-regulation in TRPV4 mRNA expression in the inner ear ganglia and kidney after KM treatment. All these mRNA and protein expression changes were eliminated by simultaneous administration of dihydroxybenzoate (300 mg/kg s.c. b.i.d., 14 days), an anti-oxidant that blocks KM ototoxicity. It is proposed that up-regulated TRPV1 expression during KM exposure may promote ganglion cell survival by contributing to neuronal depolarization, with KM-induced tinnitus and dizziness as consequences. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Pittsburgh, Sch Med, Dept Otolaryngol, Inst Eye & Ear, Pittsburgh, PA 15213 USA.
Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA 15260 USA.
Univ Pittsburgh, Dept Commun Sci, Pittsburgh, PA 15260 USA.
RP Balaban, CD (reprint author), Univ Pittsburgh, Sch Med, Dept Otolaryngol, Inst Eye & Ear, 107,Room 153,203 Lothrop St, Pittsburgh, PA 15213 USA.
EM cbalaban@pitt.edu
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NR 51
TC 38
Z9 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 132
EP 144
DI 10.1016/j.heares.2004.09.007
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200014
PM 15721568
ER
PT J
AU Zhang, YF
Dyck, RH
Hamilton, SE
Nathanson, NM
Yan, J
AF Zhang, YF
Dyck, RH
Hamilton, SE
Nathanson, NM
Yan, J
TI Disrupted tonotopy of the auditory cortex in mice lacking M-1 muscarinic
acetylcholine receptor
SO HEARING RESEARCH
LA English
DT Article
DE auditory cortex; tonotopy; frequency tuning; muscarinic receptor;
cholinergic; development; mouse
ID MOUSE CEREBRAL NEOCORTEX; DENDRITES IN-VIVO; VISUAL-CORTEX; NUCLEUS
BASALIS; PHYSIOLOGICAL MEMORY; CORTICAL DEVELOPMENT; STRIATE CORTEX;
MUTANT MICE; HOUSE MOUSE; PLASTICITY
AB Sensory cortices have multiple and distinct functional maps that systematically represent environmental information. Development of these maps is precisely controlled by a number of intrinsic and extrinsic factors. Cortical cholinergic regulation is a crucial factor for normal cortical morphogenesis. In this study, we test the role of the M-1 muscarinic acetylcholine receptor, the main muscarinic receptor subtype in the neocortex in the development of tonotopic maps in the auditory cortex. Mice lacking M-1 receptors have normal hearing sensitivity but exhibit disrupted tonotopic organization and frequency tuning in the auditory cortex. In contrast, tonotopic organization and frequency tuning remain normal in the auditory midbrain. In addition, cortical layer IV neurons of M-1 mutants exhibit significantly shorter or sparser dendrites compared to neurons of wildtype mice. In summary, our data suggest that the M-1 receptor appears to be critical for the refinement or normal maturation of cortical tonotopy that is guided by thalamocortical inputs during early development. (c) 2004 Elsevier B.V. All rights reserved.
C1 Univ Calgary, Fac Med, Dept Physiol & Biophys, Neurosci Res Grp, Calgary, AB T2N 4N1, Canada.
Univ Calgary, Dept Psychol, Calgary, AB T2N 4N1, Canada.
Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA.
RP Yan, J (reprint author), Univ Calgary, Fac Med, Dept Physiol & Biophys, Neurosci Res Grp, Calgary, AB T2N 4N1, Canada.
EM juyan@ucalgary.ca
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NR 61
TC 20
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD MAR
PY 2005
VL 201
IS 1-2
BP 145
EP 155
DI 10.1016/j.heares.2004.10.003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 905YA
UT WOS:000227606200015
PM 15721569
ER
PT J
AU Chen, GD
Liu, Y
AF Chen, GD
Liu, Y
TI Mechanisms of noise-induced hearing loss potentiation by hypoxia
SO HEARING RESEARCH
LA English
DT Article
DE noise-induced hearing loss; hypoxia; cochlear potentials; gene
expression in the cochlea
ID OUTER HAIR-CELLS; SUCCINIC-DEHYDROGENASE; COCHLEAR AMPLIFIER; ACTIN;
THRESHOLD; INNER; ELECTROMOTILITY; PRESTIN; ELEMENT; PLASMA
AB Potentiation of noise-induced permanent threshold shift (PTS) by hypoxia has been reported [Hear. Res. 172 (1-2) (2002) 186]. In this study in rats, effects of noise (110 dB SPL), hypoxia (10% O-2), and their combination have been determined on different cochlear potentials and on the expression of genes coding proteins in the outer hair cell (OHC) membrane skeleton (beta-actin) and in the mitochondrial respiratory chain (SDHa & b). The noise exposure alone caused CAP threshold shift only in the noise-band. The combined exposure to noise and hypoxia caused an about 40-dB PTS at all frequencies within and above the noise band. Loss of the cochlear amplification was not always related to the CM-suppression. SP was only affected at high frequencies by the combined exposure. Gene expression of beta-actin was up-regulated by the noise exposure, which was blocked by hypoxia. Gene expression of SDHa was also up-regulated by the noise and the combined exposure. The data suggest that loss of the cochlear active process, due to damage to the OHC membrane skeleton and to the cellular energy generation system, is related to the noise-induced hearing loss potentiation by hypoxia. Inner hair cell damage may also be involved in the hypoxia potentiation in the basal turn. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Oklahoma City, OK 73117 USA.
RP Chen, GD (reprint author), Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, POB 26901,1110 N Stonewall Ave, Oklahoma City, OK 73117 USA.
EM guangdi-chen@ouhsc.edu
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NR 36
TC 13
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2004.08.016
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700001
PM 15668034
ER
PT J
AU Aggarwal, PS
Lowen, SB
Colburn, HS
Dolphin, WF
AF Aggarwal, PS
Lowen, SB
Colburn, HS
Dolphin, WF
TI Intrinsic oscillations in spike trains indicate non-renewal statistics
due to convergence of inputs in dorsal cochlear nucleus neurons
SO HEARING RESEARCH
LA English
DT Article
DE intrinsic oscillations; spectral analysis; inter-spike interval
regularity; dorsal cochlear nucleus; refractory; integrate-and-fire;
convergence; encoding
ID UNANESTHETIZED DECEREBRATE CATS; INTRACELLULAR-RECORDINGS; INHIBITORY
INTERACTIONS; RESPONSE PROPERTIES; DISCHARGE PATTERNS; AUDITORY-SYSTEM;
ELECTRIC FISH; UNITS; CELLS; GERBIL
AB The occurrence of intrinsic oscillations (IOs) in a unit's discharge is reflected by a prominent peak in the power spectrum (i.e., Fourier transform of the autocorrelation function) of spike trains obtained from single-unit discharge, at a frequency independent of stimulus spectral characteristics. IOs have been reported by researchers in the dorsal cochlear nucleus (DCN) of both the cat and the Mongolian gerbil. It has been hypothesized that IOs are related to inter-spike interval (ISI) regularity (e.g., [Hear. Res. 58 (1992) 153]). This hypothesis is tested in this paper. Responses to multiple presentations of 50-300 ms duration tone bursts, at and near the unit's best frequency (BF) at 20-60 dB rethreshold were recorded from DCN units of barbiturate-anesthetized (30 units), as well as decerebrate (53 units) Mongolian gerbils. IOs in the recordings were then compared with the IOs in simulations of spiking-neuron models. The models were selected because: (1) their ISI regularity characteristics follow those of experimental data and (2) their 10 properties are completely determined by their ISI regularity. Such comparison reveals that Ghoshal's hypothesis fails for a fraction of the units. These results suggest a re-evaluation of the purported relationship between IOs, ISI regularity, and SAM response. Alternate hypotheses are proposed here using computational models that are based on convergence of multiple neural inputs onto the unit under study. These models produce non-renewal statistics that resemble those of the experimental data, as is evident from IO-based analysis. (C) 2004 Elsevier B.V. All rights reserved.
C1 Boston Univ, Biomed Engn Dept, Boston, MA 02215 USA.
Boston Univ, Ctr Memory & Brain, Boston, MA 02215 USA.
Mclean Hosp, Brain Imaging Ctr, Belmont, MA 02478 USA.
RP Aggarwal, PS (reprint author), Boston Univ, Biomed Engn Dept, 2 Cummington St, Boston, MA 02215 USA.
EM prateekji@hotmail.com
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NR 43
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 10
EP 28
DI 10.1016/j.heares.2004.08.010
PG 19
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700002
PM 15668035
ER
PT J
AU Henson, MM
Madden, VJ
Rask-Andersen, H
Henson, OW
AF Henson, MM
Madden, VJ
Rask-Andersen, H
Henson, OW
TI Smooth muscle in the annulus fibrosus of the tympanic membrane in bats,
rodents, insectivores, and humans
SO HEARING RESEARCH
LA English
DT Article
DE tympanic membrane; tympanic annulus; annulus fibrosus; smooth muscle
ID RAT
AB The annulus fibrosus and its attachment to the bony tympanic ring were studied in a series of mammals. In the pallid bat, Antrozous pallidus, there is an extensive plexus of large interconnected blood sinuses in the part of the annulus that borders the tympanic bone. The spaces between the sinuses are packed with smooth muscle cells. Most of the cells have a predominately radial orientation; they extend from the bony tympanic sulcus to a dense collagenous matrix (apical zone) where radially oriented fibers of the pars tensa are confluent with the annulus. The muscles and vessels constitute a myovascular zone. A structurally similar myovascular zone is also present in the European hedgehog. In rodents, the annulus lacks the large interconnected blood sinuses but many small vessels are present. Smooth muscle is concentrated in the broad area of attachment of the annulus to the tympanic bone. In the gerbil, smooth muscle seems to be concentrated in the central part of the width of the annulus where it is attached to bone and radiates toward the tympanic membrane. In humans collections of radially oriented smooth muscle cells were found in several locations. The smooth muscle in all species studied appears to form a rim of contractile elements for the pars tensa. This arrangement suggests a role in controlling blood flow and/or creating and maintaining tension on the tympanic membrane. (C) 2004 Published by Elsevier B.V.
C1 Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA.
Univ N Carolina, Dept Otolaryngol, Chapel Hill, NC 27599 USA.
Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA.
Univ Hosp, Dept Otorhinolaryngol, S-75185 Uppsala, Sweden.
RP Henson, OW (reprint author), Univ N Carolina, Dept Cell & Dev Biol, Taylor Hall,CB 7090, Chapel Hill, NC 27599 USA.
EM owh@med.unc.edu
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NR 21
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 29
EP 37
DI 10.1016/j.heares.2004.09.004
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700003
PM 15668036
ER
PT J
AU Gehr, DD
Werner, YL
AF Gehr, DD
Werner, YL
TI Age effects and size effects in the ears of gekkonomorph lizards: inner
ear
SO HEARING RESEARCH
LA English
DT Article
DE cochlear duct; inner ear; basilar papilla; directional asymmetry; sexual
dimorphism; otoconia; variation; geckos
ID HAIR-CELL REGENERATION; MIDDLE-EAR; AUDITORY-SENSITIVITY; TECTORIAL
MEMBRANE; PODARCIS-SICULA; GEKKO-GECKO; BODY-SIZE; ASYMMETRY; OTOCONIA;
COCHLEA
AB Audiograms have indicated greater auditory sensitivity in larger than in smaller geckos; part of this difference, interspecifically and intraspecifically, is explained by middle-ear proportions. To investigate the contribution of the inner ear to the variation in sensitivity, we examined it in museum specimens representing 11 species and three subfamilies. We measured papilla basilaris length, and, when intact, the saccular otoconial mass. Papilla length approximated 1% of rostrum-anus length in large geckos but 2% in small geckos; in some species some inter-aural difference was indicated. Over the lumped material, relative papilla length varied as a function of body length, with highly significant correlation. Similar relations prevailed within each subfamily. However, intraspecifically the correlation of papilla basilaris length with animal size was usually nonsignificant. Hair cell populations assessed from SEM photographs were larger in the larger species but intraspecifically did not relate to an individual's size. Hence interspecifically, the dependence of auditory sensitivity on animal size seems supported by inner-ear differences but intraspecifically this relation derives only from the middle ear. Otoconial mass, as measured by its volume, was correlated with animal length both interspecifically and intraspecifically. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Penn, Dept Otohinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA.
Tech Univ Munich, ENT Dept, D-81664 Munich, Germany.
RP Werner, YL (reprint author), Hebrew Univ Jerusalem, Dept Evolut Systemat & Ecol, IL-91904 Jerusalem, Israel.
EM yehudah_w@yahoo.com
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NR 62
TC 8
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 38
EP 50
DI 10.1016/j.heares.2004.08.013
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700004
PM 15668037
ER
PT J
AU Coppens, AG
Gilbert-Gregory, S
Steinberg, SA
Heizmann, C
Poncelet, L
AF Coppens, AG
Gilbert-Gregory, S
Steinberg, SA
Heizmann, C
Poncelet, L
TI Inner ear histopathology in "nervous Pointer dogs" with severe hearing
loss
SO HEARING RESEARCH
LA English
DT Article
DE dog; hearing loss; hereditary; neuroepithelial degeneration
ID POSTNATAL-DEVELOPMENT; HEREDITARY DEAFNESS; CONGENITAL DEAFNESS;
INHERITED DEAFNESS; AUDITORY-SYSTEM; DALMATIANS; MODEL;
IMMUNOLOCALIZATION; DEGENERATION; MATURATION
AB Ten puppy dogs (82, 131 or 148 days-old) from a Pointer cross-colony, exhibiting a juvenile severe hearing loss transmitted as an amosomal recessive trait, were used for histopathological characterization of the inner ear lesion. Immunostaining with calbindin, Na,K-ATPase, cytokeratins, S100, S100A1 and S100A6 antisera were helpful in identifying the different cell types in the degenerated cochleae. Lesions, restricted to the Corti's organ and spiral ganglion, were bilateral but sometimes slightly asymmetrical. Mild to severe lesions of the Corti's organ were unevenly distributed among the different parts of the middle and basal cochlear turns while the apical turn remained unaffected at 148 days. In 82 day-old puppies (n = 2), severe lesions of the Corti's organ, meaning that it was replaced by a layer of unidentifiable cells, involved the lower middle and upper basal turns junction area, extending in the upper basal turn. Mild lesions of the Corti's organ, with both hair and supporting cells abnormalities, involved the lower middle turn and extended from the rest of upper basal turn. into the lower basal turn. The outer hair cells (ohc) were more affected than the inner hair cell (ihc). The lesions extended towards the basal end of the cochlea in the 131 (n = 5) and 148 (n = 3) day-old puppies. Additionally, the number of spiral ganglion neurons was reduced in the 131 and 148 day-old puppies; it is earlier than observed in most other canine hereditary deafness. These lesions were interpreted as a degeneration of the neuroepithelial type. This possible animal model might provide information about progressive juvenile hereditary deafness and neuronal retrograde degeneration investigations in human. (C) 2004 Elsevier B.V. All rights reserved.
C1 Free Univ Brussels, Fac Med, Lab Vet Anat, Dept Anat & Embryol, B-1070 Brussels, Belgium.
Univ Penn, Sch Vet Med, Sect Neurol Ophthalmol, Philadelphia, PA 19104 USA.
Univ Zurich, Div Clin Chem, Dept Paediat, Zurich, Switzerland.
RP Coppens, AG (reprint author), Free Univ Brussels, Fac Med, Lab Vet Anat, Dept Anat & Embryol, 808 Lennik St, B-1070 Brussels, Belgium.
EM angelique.coppens@ulb.ac.be
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NR 36
TC 9
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 51
EP 62
DI 10.1016/j.heares.2004.08.019
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700005
PM 15668038
ER
PT J
AU Rybalko, N
Syka, J
AF Rybalko, N
Syka, J
TI Effect of noise exposure on gap detection in rats
SO HEARING RESEARCH
LA English
DT Article
DE noise exposure; temporal resolution; gap detection; hearing loss;
tinnitus; rat
ID HEARING-IMPAIRED LISTENERS; AWAKE GUINEA-PIGS; INFERIOR COLLICULUS;
EVOKED-RESPONSES; TEMPORAL GAP; FREQUENCY; THRESHOLDS; CHINCHILLA;
BANDWIDTH; TINNITUS
AB The effects of intense (110-120 dB) noise exposure (broadband noise for one hour) on temporal resolution was estimated in rats by measuring the behavioural gap detection threshold (GDT). Changes in GDT after 120 dB noise exposure were compared with changes in the threshold and amplitude of middle latency responses (MLR) recorded in response to tone stimuli. GDT values increased from 1.6 to 4.3 or 7.8 ms after exposure to 110 or 115 dB SPL, respectively; GDT recovered to pre-exposure values in 3-7 days. Three main types of noise-induced changes were observed after 120 dB SPL exposure: (I) GDT changes similar to those following noise exposure to 115 dB SPL and maximal hearing threshold shifts (TSs) at high frequencies of about 45 dB; (II) more pronounced changes in GDT (up to 60 ms) with maximal hearing threshold shifts of about 65 dB and (III) a lack of reliable responses to gap during the first weeks post-exposure with maximal hearing threshold shifts of about 80 dB. An increased GDT was present two months after noise exposure in animals with types II and III post-exposure changes; enhanced MLR amplitudes were also found in most of these in the first post-exposure week. The pronounced deficit in gap detection in some rats after 120 dB SPL noise exposure may signal the presence of a noise-induced tinnitus. (C) 2004 Elsevier B.V. All rights reserved.
C1 Acad Sci Czech Republ, Inst Expt Med, Prague 14220 4, Czech Republic.
RP Rybalko, N (reprint author), Acad Sci Czech Republ, Inst Expt Med, Videnska 1083, Prague 14220 4, Czech Republic.
EM rybalko@biomed.cas.cz
RI Rybalko, Natalia/H-2629-2014; Syka, Josef/H-3103-2014
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NR 43
TC 13
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 63
EP 72
DI 10.1016/j.heares.2004.08.014
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700006
PM 15668039
ER
PT J
AU van Wieringen, A
Carlyon, RP
Laneau, J
Wouters, J
AF van Wieringen, A
Carlyon, RP
Laneau, J
Wouters, J
TI Effects of waveform shape on human sensitivity to electrical stimulation
of the inner ear
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; behavioural thresholds; symmetric and asymmetric
waveforms
ID PSYCHOPHYSICAL DETECTION THRESHOLDS; COCHLEAR IMPLANT USERS;
AUDITORY-NERVE; SPEECH RECOGNITION; MONOPHASIC STIMULATION;
ACTION-POTENTIALS; RESPONSES; SINGLE; DURATION; CONFIGURATION
AB Psychophysical measures of the electrically stimulated human auditory system were obtained for different types of symmetric and asymmetric charge-balanced waveforms. Absolute detection thresholds of biphasic, pseudomonophasic, and 'alternating monophasic' current waveforms delivered by a bipolar intra-cochlear electrode pair were determined for four subjects implanted with the LAURA device. Thresholds for alternating monophasic stimuli, in which anodic and cathodic phases alternated every 5 ms, were 5-8 dB lower than for the biphasic waveforms for all four subjects. For two of the four subjects, thresholds for the pseudomonophasic waveforms were also significantly lower than for the biphasic waveforms. These pseudomonophasic thresholds were greatly affected neither by a 500-mus gap inserted between the two phases, nor by whether the shorter phase preceded or followed the longer one. Loudness balancing measures performed at the most comfortable levels also showed that, for equal loudness, alternating monophasic stimuli required a lower level than biphasic and pseudomonophasic waveforms. For three of the four subjects, the dynamic ranges of the pseudomonophasic (but not alternating monophasic) waveforms were greater than those of the biphasic waveforms. The results demonstrate that thresholds and dynamic ranges of human cochlear implant users can be controlled by manipulating the way in which the charge produced by the initial phase of an electrical pulse is recovered. (C) 2004 Elsevier B.V. All rights reserved.
C1 Catholic Univ Louvain, Lab Exp ORL, B-3000 Louvain, Belgium.
MRC Cognit & Brain Sci Unit, Cambridge CB2 2EF, England.
RP van Wieringen, A (reprint author), Catholic Univ Louvain, Lab Exp ORL, Kapucijnenvoer 33, B-3000 Louvain, Belgium.
EM astrid.vanwieringen@uz.kuleuven.ac.be
RI Carlyon, Robert/A-5387-2010; Wouters, Jan/D-1800-2015
CR [Anonymous], SPSS 10 0
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*WORLD MED ASS, 1975, REC GUID MED DOCT BI
NR 35
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 73
EP 86
DI 10.1016/j.heares.2004.08.006
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700007
PM 15668040
ER
PT J
AU Spicer, SS
Schulte, BA
AF Spicer, SS
Schulte, BA
TI Novel structures in marginal and intermediate cells presumably relate to
functions of apical versus basal strial strata
SO HEARING RESEARCH
LA English
DT Article
DE K+ flow; upper stria; lower stria; fine structure/function
ID MOUSE INNER-EAR; ENDOCOCHLEAR POTENTIAL GENERATION; GUINEA-PIG COCHLEA;
OUTER HAIR-CELLS; GERBIL COCHLEA; FINE-STRUCTURE; ION-TRANSPORT;
ENDOPLASMIC-RETICULUM; SPIRAL LIGAMENT; PLACE-FREQUENCY
AB Prior ultrastructural studies showed that K+ supplied to the stria vascularis came from recycling ions from the organ of Corti or perilymph to strial basal cells. A newly distinguished basal subtype of intermediate cell (BIC) completely covered the basal cells with a leaf-like horizontal process and appeared situated to absorb from them all of the recycled K+. The basal region of marginal cells (MCs) projected foot-like and enlarged processes to border BICs opposite an unique ca. 150 A space. These basal MC processes appeared positioned to resorb part of the K+ recycled to BICs. A second, upper subtype of IC (UIC), occupying middle to upper strial strata, contacted BIC's extensively. UICs were thus located to resorb from BICs the portion of the recycled K+ not forwarded to basal MC processes. The apical segment of MCs projected mitochondria-filled primary processes and numerous associated secondary processes. The Na,K-ATPase-rich secondary processes populated mid to upper stria where they could siphon K+ from UICs and resorb and secrete the ions thus generating the 150 mM [KCl] of endolymph. The morphologic relationship of basal marginal cell processes to BICs differed so strikingly from the relation of upper MC processes to UICs as to suggest a different function for basal stria, one possibly concerned with generating the endocochlear potential. (C) 2004 Elsevier B.V. All rights reserved.
C1 Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA.
RP Schulte, BA (reprint author), Med Univ S Carolina, Dept Pathol & Lab Med, 165 Ashley Ave,Suite 309,POB 250908, Charleston, SC 29425 USA.
EM schulteb@musc.edu
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NR 53
TC 20
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 87
EP 101
DI 10.1016/j.heares.2004.09.006
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700008
PM 15668041
ER
PT J
AU Hildebrand, MS
de Silva, MG
Klockars, T
Solares, CA
Hirose, K
Smith, JD
Patel, SC
Dahl, HHM
AF Hildebrand, MS
de Silva, MG
Klockars, T
Solares, CA
Hirose, K
Smith, JD
Patel, SC
Dahl, HHM
TI Expression of the carrier protein apolipoprotein D in the mouse inner
ear
SO HEARING RESEARCH
LA English
DT Article
DE apolipoprotein D; inner ear; potassium recycling; spiral ligament;
spiral limbus; outer hair cells; apoD knockout mouse model
ID OUTER HAIR-CELLS; SPIRAL-LIGAMENT; LIMBUS-SPIRALIS; F1-HYBRID STRAINS;
MAMMALIAN COCHLEA; HEARING-LOSS; RAT COCHLEA; DEAFNESS; GENE;
COTRANSPORTER
AB The cochlear portion of the inner ear converts movements produced by sound waves into electrical impulses. Transcripts enriched in the cochlea are likely to have an important role in hearing. In this paper, we report that microarray analyses of the Soares NMIE inner ear library revealed cochlear enriched expression of apolipoprotein D (apoD), a glycoprotein and member of the lipocalin family that transport small hydrophobic ligands. The cochlear enriched expression of Apod was validated by quantitative real time PCR analysis. To investigate the function of apoD in the inner ear the transcript and protein were localised in the cochlea. Apod messenger RNA (mRNA) expression was localised to the spiral ligament and spiral limbus, particularly in the suprastrial and supralimbral regions. The apoD protein was detected in the spiral ligament, spiral limbus and also in the outer hair cells of the organ of Corti. Investigation of cell lines exhibiting characteristics of hair and supporting cells revealed no Apod mRNA expression in these cells. This suggests transport of the protein within the cochlea, followed by internalisation into outer hair cells. The spiral limbus and ligament contain subpopulations of fibrocytes that are intimately involved in regulation of ion balance in the cochlear fluids and type I, II and III fibrocytes of the spiral ligament were all shown to be positive for apoD protein. On the basis of these results it was hypothesised that apoD could be involved in maintaining cochlear fluid homeostasis. To determine whether the apoD gene product was important for normal auditory function the hearing ability of an apoD knockout mouse was tested. The mouse was found to have a hearing threshold that was not significantly different to the control strain. (C) 2004 Elsevier B.V. All rights reserved.
C1 Royal Childrens Hosp, Murdoch Childrens Res Inst, Dept Gene Identificat & Express, Parkville, Vic 3052, Australia.
Univ Melbourne, Dept Biochem & Mol Biol, Melbourne, Vic, Australia.
Cleveland Clin Fdn, Head & Neck Inst, Cleveland, OH USA.
Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH USA.
Cleveland Clin Fdn, Lerner Res Inst, Dept Cell Biol, Cleveland, OH USA.
New England Biomed Res Ctr & VA Connecticut Healt, Newington, CT USA.
Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Melbourne, Vic, Australia.
RP Dahl, HHM (reprint author), Royal Childrens Hosp, Murdoch Childrens Res Inst, Dept Gene Identificat & Express, Flemington Rd, Parkville, Vic 3052, Australia.
EM henrik.dahl@mcri.edu.au
RI de Silva, Michelle/E-5848-2011
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NR 56
TC 11
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 102
EP 114
DI 10.1016/j.heares.2004.08.018
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700009
PM 15668042
ER
PT J
AU Kluk, K
Moore, BCJ
AF Kluk, K
Moore, BCJ
TI Factors affecting psychophysical tuning curves for hearing-impaired
subjects with high-frequency dead regions
SO HEARING RESEARCH
LA English
DT Article
DE psychophysical tuning curve; dead region; beats; combination tone
ID AUDITORY FILTER SHAPES; COMBINATION TONES; MASKING PATTERNS; PURE-TONE;
AMPLITUDE-MODULATION; SINUSOIDAL CARRIERS; NORMALLY HEARING; RELATIVE
ROLE; BAND NOISE; LISTENERS
AB A dead region (DR) is a region of the cochlea where there are no functioning inner hair cells and/or neurons. DRs can be detected using the threshold-equalizing-noise (TEN) test, but psychophysical tuning curves (PTCs) are sometimes used to give a more precise estimate of the edge frequency of a DR; a shifted tip of the PTC indicates a DR. We show here that the shapes of PTCs for hearing-impaired subjects can be influenced by the detection of beats and simple difference tones (SDTs). As a result, PTCs can have tips at f(s), even when f(s) falls in a DR. PTCs were measured for subjects with mild to moderate low-frequency and severe high-frequency hearing loss using sinusoidal and narrowband noise maskers (80-, 160-, 320-Hz wide): (1) in quiet; (2) in the presence of additional lowpass filtered noise (LF noise) designed to mask SDTs; (3) in the presence of a pair of low-frequency tones designed to interfere with the detection of beats (MDI tones). In condition (1), the PTCs were often W-shaped, with a sharp tip at f(s). This occurred less for the wider noise bandwidths. For subjects with good low-frequency hearing, the LF noise often reduced or eliminated the tip at f(s), suggesting that this tip was partly caused by detection of SDTs. For the sinusoidal and 80-Hz wide noise maskers, the addition of the MDI tones reduced the masker level required for threshold for masker frequencies adjacent to f(s), for nearly all subjects, suggesting a strong influence of beat detection. To minimize the influence of beats, we recommend using noise maskers with a bandwidth of 160 or (preferably) 320 Hz. In cases of near-normal hearing at low frequencies, we recommend using an additional LF noise to mask SDTs. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
RP Kluk, K (reprint author), Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England.
EM kk278@cam.ac.uk
RI Moore, Brian/I-5541-2012
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NR 55
TC 37
Z9 40
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD FEB
PY 2005
VL 200
IS 1-2
BP 115
EP 131
DI 10.1016/j.heares.2004.09.003
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 896FJ
UT WOS:000226919700010
PM 15668043
ER
PT J
AU Wu, XH
Wang, C
Chen, J
Qu, HW
Li, WR
Wu, YH
Schneider, BA
Li, L
AF Wu, XH
Wang, C
Chen, J
Qu, HW
Li, WR
Wu, YH
Schneider, BA
Li, L
TI The effect of perceived spatial separation on informational masking of
Chinese speech
SO HEARING RESEARCH
LA English
DT Article
DE Chinese speech; nonsense sentences; precedence effect; perceived spatial
separation; informational masking; energetic masking
ID ENERGETIC MASKING; INTELLIGIBILITY; NOISE; PERCEPTION; RELEASE
AB The effect of perceived spatial separation, induced by the precedence effect, on release from noise or speech masking was investigated. Listeners were asked to orally repeat Chinese nonsense sentences, which were spoken by a female talker and presented by both the left (-45degrees) and right (+45degrees) loudspeakers, when maskers, which were either speech-spectrum noise sounds or Chinese nonsense sentences spoken by two other female talkers, were presented by the same two loudspeakers. Delays between identical sounds presented over the two loudspeakers were used to control the perceived locations of the target (right only) and masker (right, center, or left). The results show that perceived 45degrees and 90degrees separations of target speech from masking speech led to equivalently marked improvement in speech recognition, even though the degree of improvement was smaller than that reported in [J. Acoust. Soc. Am. 106 (1999) 3578 (using English nonsense speech)]. When the masker was noise, however, perceived separation only marginally improved speech recognition. These results indicate that release from informational masking, due to perceived target/masker spatial separation induced by the precedence effect, also occurs for tonal Chinese speech. Compared to the 45degrees perceived within-hemifield separation, the 90degrees perceived cross-hemifield separation does not produce further unmasking. (C) 2004 Elsevier B.V. All rights reserved.
C1 Peking Univ, Natl Key Lab Machine Percept, Speech & Hearing Res Ctr, Beijing 100871, Peoples R China.
Peking Univ, Dept Psychol, Beijing 100871, Peoples R China.
Univ Toronto, Dept Psychol, Ctr Res Biol Commun Syst, Mississauga, ON L5L 1C6, Canada.
RP Wu, XH (reprint author), Peking Univ, Natl Key Lab Machine Percept, Speech & Hearing Res Ctr, Beijing 100871, Peoples R China.
EM wxh@cis.pku.edu.cn
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NR 24
TC 27
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 1
EP 10
DI 10.1016/j.heares.2004.03.010
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200001
PM 15574295
ER
PT J
AU Samadi, DS
Saunders, JC
Crenshaw, EB
AF Samadi, DS
Saunders, JC
Crenshaw, EB
TI Mutation of the POU-domain gene Brn4/Pou3f4 affects middle-ear sound
conduction in the mouse
SO HEARING RESEARCH
LA English
DT Article
DE POU-domain genes; Brn4/Pou3f4; middle ear; velocity transfer functions;
transgenic mice; umbo response; targeted mutagenesis; laser
interferometry
ID TYMPANIC-MEMBRANE PERFORATIONS; AUDITORY DEVELOPMENT; INNER-EAR; CATS
AB Mutagenesis of the POU-domain gene Brn4/Pou3f4 causes defects in the cochlear duct, semicircular canal, temporal bone and stapes footplate. The footplate defect suggested a middle-ear conductive component to the hearing loss associated with this mutation. This was examined by measuring velocity transfer functions at the umbo of wild type and knockout mice during sound stimulation of the tympanic membrane. When the median umbo velocity of test frequencies in the two groups were compared, the mid-range frequencies of the knockout mice showed a statistically reliable reduction in velocity (maximum of 13 dB) and high variability among animals. These results indicated that mutation of the POU-domain gene, Brn4, changed middle-ear sound conduction when measured at the umbo.
The origin of the abnormal velocity response was sought by puncturing a hole in the pars flaccida (PF), and subsequently, measuring movements at the umbo and the head of the long arm of the incus. This hole permitted us to measure velocity at the tip of the incus long arm, just above the incudostapedial joint. The comparison of umbo behavior in both groups with PF perforated showed a loss of sensitivity in the mid-range frequencies of the knockout animals. A comparison of incus velocity in the two groups also exhibited a velocity reduction in the mid-range frequencies of the knockout animals. The reduction at the incus, however, was milder than observed at the umbo. The effect of the perforation in, and variability of, the knockout incus responses may have masked a more potent mid-range frequency effect. Nevertheless, evaluation of the stapes and oval window in knockout mice showed variable pathology from ear to ear. The presence of this pathology, the mid-frequency loss in incus sensitivity and the variability in incus velocity among animals suggested that abnormal stapes behavior in Brn4 deficient mice may determine the response of the ossicles, and thus account for the abnormal mid-frequency umbo behavior seen in knockout animals. (C) 2004 Elsevier B.V. All rights reserved.
C1 Childrens Hosp Philadelphia, Mammalian Neurogenet Grp, Ctr Childhood Commun, Div Pediat Otolaryngol,Abraham Res Ctr 712, Philadelphia, PA 19104 USA.
Univ Penn, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA.
RP Crenshaw, EB (reprint author), Childrens Hosp Philadelphia, Mammalian Neurogenet Grp, Ctr Childhood Commun, Div Pediat Otolaryngol,Abraham Res Ctr 712, 34th & Civic Blvd, Philadelphia, PA 19104 USA.
EM crenshaw@email.chop.edu
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NR 24
TC 9
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 11
EP 21
DI 10.1016/j.heares.2004.07.013
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200002
PM 15574296
ER
PT J
AU Yang, JJ
Tsai, CC
Hsu, HM
Shiao, JY
Su, CC
Li, SY
AF Yang, JJ
Tsai, CC
Hsu, HM
Shiao, JY
Su, CC
Li, SY
TI Hearing loss associated with enlarged vestibular aqueduct and Mondini
dysplasia is caused by splice-site mutation in the PDS gene
SO HEARING RESEARCH
LA English
DT Article
DE PDS; EVA; Mondini dysplasia; prelingual deafness; Pendrin syndrome;
hearing
ID PENDRED-SYNDROME; MOLECULAR ANALYSIS; AUDITORY-SYSTEM; DEAFNESS;
IDENTIFICATION; FREQUENCIES; DISCOVERY; SPECTRUM; PROTEIN; IODIDE
AB Recessive mutations of PDS gene are the common causes of Pendred syndrome and non-syndromic hearing loss associated with temporal bone abnormalities ranging from isolated enlargement of the vestibular aqueduct (EVA) to Mondini dysplasia. In this study we evaluate the relationship between EVA and Mondini dysplasia in 10 prelingual deaf patients and PDS gene mutation. One of three mutations, IVS7 - 2A --> G, INS16 - 6G -->A or IVS15 + 5G --> A, was identified in the PDS gene in each patient. In family studies of four probands with the IVS7 - 2A --> G mutation, we found that this mutation was inherited from the same mutant alleles of parental origin. The effect of IVS7 - 2A --> G mutation on PDS gene expression was determined by reverse transcription and polymerase chain reaction (RT-PCR). Sequencing of the RT-PCR products revealed that the PDS transcripts from the allele with 1VS7 - 2A --> G mutation lose the entire exon 8, resulting in a joining of exons 7 and 9. Deletion of the exon 8 results in frameshift and premature termination of translation. Haplotype analysis showed a significant haplotype shared among the family members carrying IVS7 - 2A --> G mutation, suggesting that they may be derived from a common ancestor. Our results provide evidence that hearing loss with EVA and Mondini dysplasia may be caused by splice-site mutation in the PDS gene. (C) 2004 Elsevier B.V. All rights reserved.
C1 Chung Shan Med Univ, Genet Lab, Taichung 402, Taiwan.
Chung Shan Med Univ, Dept Life Sci, Taichung 402, Taiwan.
Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
Taichung Vet Gen Hosp, Dept Otorhinolaryngol, Taichung, Taiwan.
Tian Sheng Mem Hosp, Tong Kong, Pin Tong, Taiwan.
RP Li, SY (reprint author), Chung Shan Med Univ, Genet Lab, 110,Sec 1,Chien Kuo N Rd, Taichung 402, Taiwan.
EM syl@csmu.edu.tw
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NR 34
TC 32
Z9 42
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 22
EP 30
DI 10.1016/j.heares.2004.08.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200003
PM 15574297
ER
PT J
AU Kozou, H
Kujala, T
Shtyrov, Y
Toppila, E
Starck, J
Alku, P
Naatanen, R
AF Kozou, H
Kujala, T
Shtyrov, Y
Toppila, E
Starck, J
Alku, P
Naatanen, R
TI The effect of different noise types on the speech and non-speech
elicited mismatch negativity
SO HEARING RESEARCH
LA English
DT Article
DE noise; mismatch negativity; event-related brain potentials; speech
ID HUMAN BRAIN; NORMAL-HEARING; WHITE-NOISE; MASKING; RECOGNITION;
PERCEPTION; SOUNDS; REPRESENTATION; THRESHOLD; ACCURACY
AB The effect of different types of real-life noise on the central auditory processing of speech and non-speech sounds was evaluated by the means of mismatch negativity and behavioral responses. Subjects (19-34 years old; 6 males, 4 females) were presented, in separate conditions, with either speech or non-speech stimuli of approximately equal complexity in five background conditions: babble noise, industrial noise, traffic noise, wide band noise, and silent condition. Whereas there were no effects of stimuli or noise on the behavioral responses, the MMN results revealed that speech and non-speech sounds are processed differently both in silent and noisy conditions. Speech processing was more affected than non-speech processing in all noise conditions. Moreover, different noise types had a differential effect on the pre-attentive discrimination, as reflected in MMN, on speech and non-speech sounds. Babble and industrial noises dramatically reduced the MMN amplitudes for both stimulus types, while traffic noise affected only speech stimuli. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, FIN-00014 Helsinki, Finland.
Alexandria Sch Med, Dept Otolaryngol Head & Neck Surg, Alexandria, Egypt.
Univ Helsinki, Helsinki Coll Adv Studies, FIN-00014 Helsinki, Finland.
Univ Helsinki, Inst Brain Res, Helsinki, Finland.
MRC, Cognit & Brain Sci Unit, Cambridge, England.
Finnish Inst Occupat Hlth, Dept Phys, Helsinki, Finland.
Helsinki Univ Technol, Lab Acoust & Audio Signal Proc, FIN-02150 Espoo, Finland.
RP Kujala, T (reprint author), Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, POB 9, FIN-00014 Helsinki, Finland.
EM teija.m.kujala@helsinki.fi
RI Alku, Paavo/E-2400-2012; Shtyrov, Yury/I-3421-2013
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NR 28
TC 20
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 31
EP 39
DI 10.1016/j.heares.2004.07.010
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200004
PM 15574298
ER
PT J
AU Glueckert, R
Pfaller, K
Kinnefors, A
Schrott-Fischer, A
Rask-Andersen, H
AF Glueckert, R
Pfaller, K
Kinnefors, A
Schrott-Fischer, A
Rask-Andersen, H
TI High resolution scanning electron microscopy of the human organ of
Corti. A study using freshly fixed surgical specimens
SO HEARING RESEARCH
LA English
DT Article
DE nerve fibres; tectorial membrane; sound transduction; marginal net;
stereocilia; glycocalyx; supernumerary hair cells; supporting cells;
stria vascularis
ID COCHLEAR HAIR-CELLS; TECTORIAL MEMBRANE; GUINEA-PIG; NERVE-FIBERS;
EFFERENT INNERVATION; STRIA VASCULARIS; SPIRAL GANGLION; HUMAN FETUSES;
STEREOCILIA; BUNDLES
AB Scanning electron microscopy on immediately fixed human cochleae obtained during surgery for life-threatening petro-clival meningioma showed excellently preserved morphology. We compared the morphological findings with those from transmission electron microscopic sections of well preserved human and animal tissue. The characteristics of neural innervation, the pathways of the nerves through the organ of Corti and the intimate relation of nerves to supporting cells along their route could be studied in detail. The lateral membranes of Hensen and Claudius cells were folded creating a surface enlargement. Marginal pillars extended the distal end of the tectorial membrane and correspond to the marginal net or "randfasernetz" described earlier. Stereocilia imprints at the undersurface of the tectorial membrane go as far as to the distal end of the marginal pillars. The presence of an irregularly distributed fourth row of outer hair cell, attached to the marginal pillars, raises questions about differences in the excitation of the last row of outer hair cells. The complex nature of many supporting cells, stria vascularis and Reissner's membrane, intracellular complexities as well as surface features are described. Supernumerary inner hair cells were observed and the different arrangement of outer spiral fibres in contrast to findings in animals and variations of nerve fibres within the organ of Corti between apex and base are discussed. (C) 2004 Elsevier B.V. All rights reserved.
C1 Med Univ Innsbruck, Dept Otolaryngol, A-6020 Innsbruck, Austria.
Med Univ Innsbruck, Dept Hist & Mol Cell Biol, Inst Anat & Histol, Innsbruck, Austria.
Univ Uppsala Hosp, Dept Otolaryngol, S-75185 Uppsala, Sweden.
RP Glueckert, R (reprint author), Med Univ Innsbruck, Dept Otolaryngol, Anichstr 35, A-6020 Innsbruck, Austria.
EM rudolf.glueckert@uibk.ac.at; annelies.schrott@uibk.ac.at
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NR 72
TC 19
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 40
EP 56
DI 10.1016/j.heares.2004.05.006
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200005
PM 15574299
ER
PT J
AU Pal, B
Por, A
Pocsai, K
Szucs, G
Rusznak, Z
AF Pal, B
Por, A
Pocsai, K
Szucs, G
Rusznak, Z
TI Voltage-gated and background K(+) channel subunits expressed by the
bushy cells of the rat cochlear nucleus
SO HEARING RESEARCH
LA English
DT Article
DE bushy cells; K(+) channel subunits; TASK channel; immunochemistry;
BDS-I; phrixotoxin
ID THRESHOLD POTASSIUM CHANNEL; 2 PORE DOMAINS; SUBTHRESHOLD POTENTIALS;
OUTWARD CURRENTS; NEURONS; TANDEM; BRAIN; MOUSE; FAMILY; LOCALIZATION
AB Bushy cells of the ventral cochlear nucleus produce a single, short latency action potential at the beginning of long depolarisations. In the present work an immunochemical survey was performed to detect the presence of K(+) channel subunits which may contribute to the specific membrane properties of the bushy cells.
The immunocytochemical experiments conducted on enzymatically isolated bushy cells indicated positive immunolabelling for several subunits known to be responsible for the genesis of rapidly inactivating K(+) currents. Bushy cells showed strong expression of Kv3.4,4.2 and 4.3 subunits, with the lack of Kv1.4 specific immunoreaction. The Kv3.4-specific immunoreaction had a specific, patchy appearance. Bushy cells also expressed various members of the Kv1 subunit family, most notably Kv1.1, 1.2, 1.3 and 1.6. Weak positivity could be observed for Kv3.2 subunits. The positive immunolabelling for Kv3.4, Kv4.2 and Kv4.3 was confirmed in free-floating tissue slices. Voltage-clamp experiments performed on positively identified bushy cells in brain slices corroborated the presence and activity of Kv3.4 and Kv4.2/4.3 containing K(+) channels. Bushy cell showed strong immunopositivity for TASK-I channels too.
The results presented in this work indicate that bushy cells possess several types of voltage-gated K(+) channel subunits whose activity may contribute to the membrane properties and firing characteristics of these neurones. (C) 2004 Elsevier B.V. All rights reserved.
C1 Debrecen Univ, Dept Physiol, Med & Hlth Sci Ctr, H-4012 Debrecen, Hungary.
RP Rusznak, Z (reprint author), Debrecen Univ, Dept Physiol, Med & Hlth Sci Ctr, POB 22, H-4012 Debrecen, Hungary.
EM rz@phys.dote.hu
RI Szucs, Geza/A-2121-2008
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NR 52
TC 15
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 57
EP 70
DI 10.1016/j.heares.2004.07.020
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200006
PM 15574300
ER
PT J
AU Tognola, G
Parazzini, M
de Jager, P
Brienesse, P
Ravazzani, P
Grandori, F
AF Tognola, G
Parazzini, M
de Jager, P
Brienesse, P
Ravazzani, P
Grandori, F
TI Cochlear maturation and otoacoustic emissions in preterm infants: a
time-frequency approach
SO HEARING RESEARCH
LA English
DT Article
DE cochlear maturation; otoacoustic emissions; preterm newborn; cochlear
modeling; wavelet transform
ID MEDIAL OLIVOCOCHLEAR SYSTEM; TRAVELING-WAVE DELAY; BRAIN-STEM RESPONSES;
ACOUSTIC ADMITTANCE; HEARING IMPAIRMENT; DISTORTION-PRODUCT; EAR;
NEWBORNS; HUMANS; REFLECTANCE
AB Click-evoked otoacoustic emissions (CEOAEs) from preterm infants were analyzed to characterize developmental changes of cochlear active mechanisms. Due to their strong time-varying properties, CEOAEs were studied with a time-frequency approach the wavelet transform (WT). By means of the WT, CEOAEs were decomposed into 12 frequency bands, spanning the 0.25-6.25 kHz range. For each band, the root-mean-square (RMS) level and latency were studied as functions of both frequency and age. Because CEOAEs were averaged using the non-linear mode of acquisition, the developmental changes in observed in this study are related to the non-linear component (which is actually the most predominant component of the active cochlear response) of CEOAEs, the linear one being mostly canceled out by non-linear averaging. In our study, there was evidence that properties of CEOAE non-linear components are related to the post-conception age (PCA) in that the levels and latency of CEOAE frequency components changed until the age of about 38 weeks post-conception, whereas after 38 weeks, CEOAE features were very similar to those of term newborns. In particular, the CEOAE levels increased and latency decreased with age. The observed changes in CEOAE properties seem to reveal a development of cochlear active mechanisms, although contributions from outer and middle car development cannot be excluded. Also, in agreement with previous physiological and behavioral findings, our results revealed that the development of CEOAE properties was not the same for all the frequencies, being greater for frequencies less than or equal to4 kHz, and resembled the development of the cochlear partition, which proceeds from base to apex. (C) 2004 Elsevier B.V. All rights reserved.
C1 Politecn Milan, CNR, Ist Ingn Biomed, I-20133 Milan, Italy.
Univ Hosp Masstricht, Dept Otorhinolaryngol & Head & Neck Surg, Maastricht, Netherlands.
RP Tognola, G (reprint author), Politecn Milan, CNR, Ist Ingn Biomed, 32 Piazza Leonardo Da Vinci, I-20133 Milan, Italy.
EM gabriella.tognola@polimi.it
RI Parazzini, Marta/J-8175-2014; Tognola, Gabriella/B-9025-2015; Ravazzani,
Paolo/B-9139-2015
OI Parazzini, Marta/0000-0001-9008-7530; Ravazzani,
Paolo/0000-0003-0282-3329
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NR 40
TC 14
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 71
EP 80
DI 10.1016/j.heares.2004.08.005
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200007
PM 15574301
ER
PT J
AU Kalcioglu, MT
Bayindir, T
Erdem, T
Ozturan, O
AF Kalcioglu, MT
Bayindir, T
Erdem, T
Ozturan, O
TI Objective evaluation of the effects of intravenous lidocaine on tinnitus
SO HEARING RESEARCH
LA English
DT Article
DE tinnitus; lidocaine; treatment; otoacoustic emissions
ID OTOACOUSTIC EMISSIONS; AUDITORY-SYSTEM; SUPPRESSION; DPOAE
AB Objective: Tinnitus is one of the most common and distressing otological symptoms. Although numerous therapeutic modalities have been tried, there is no consensus regarding effective therapeutic agents up to now. The effects of lidocaine on tinnitus have been reported in literature using either subjective or audiologic tests. Nevertheless, the otoacoustic emissions (OAEs) have not been utilized to demonstrate lidocaine's effect on the cochlea in the English literature. The aim of this study was to evaluate the effect of lidocaine on tinnitus by considering the alterations with tinnitus, it induces on OAEs and subjective symptoms.
Methods: This study was performed in 30 patients with tinnitus. Twenty-eight of the patients had normal hearing and two of them evidenced mild sensorineural hearing loss. To determine the severity of tinnitus, the patients were required to fill out a tinnitus scoring scale before lidocaine infusion on the same day. Then, lidocaine was administered intravenously to each patient at a dose of mg/kg body weight over a period of 30 min. Spontaneous otoacoustic emissions (SOAEs) and distortion product otoacoustic 1.5 mg emissions (DPOAEs) were measured three times; namely before lidocaine injection, at 25 min after injection and on the next day. The severity of tinnitus was scored again 1 d, 1 wk and 1 mo after lidocaine administration.
Results: Immediately after infusion, four patients (13.3%) declared total suppression of tinnitus, whereas three patients (10%) reported only partial relief in tinnitus subjectively. The patients, who had a subjective improved response (group 1) were compared with the patients, who had no response (group 2). Statistically significant changes (p < 0.05) in DPOAE response/growth or input/output (I/O) functions were observed at 1, 2, 3, 4 and 6 kHz frequencies in lidocaine responders and at 1, 2, 3, 4 and 5 kHz frequencies in no responders at different primary stimulus levels. Statistically significant changes (p < 0.05) were seen at 2 kHz for 53 dB and at 3 kHz for 62 dB SPL primaries in both groups. When the significant results of these two groups were compared with each other, differences were found insignificant.
Conclusion: Systematic OAE measurements revealed that no changes occurred in SOAE and DPOAE levels in that alterations disappeared the next day. Subjective relief from tinnitus was stated in some of the patients and lasted for 4 wk at longest. (C) 2004 Elsevier B.V. All rights reserved.
C1 Inonu Univ, Sch Med, Dept Otorhinolaryngol, Turgut Ozal Med Ctr, TR-44069 Malatya, Turkey.
RP Kalcioglu, MT (reprint author), Inonu Univ, Sch Med, Dept Otorhinolaryngol, Turgut Ozal Med Ctr, TR-44069 Malatya, Turkey.
EM mtkalcioglu@hotmail.com
RI OZTURAN, ORHAN/E-9610-2012; Kalcioglu, Mahmut/I-5884-2013; OZTURAN,
ORHAN/B-4984-2015
OI OZTURAN, ORHAN/0000-0002-6129-8627
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NR 29
TC 9
Z9 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 81
EP 88
DI 10.1016/j.heares.2004.08.004
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200008
PM 15574302
ER
PT J
AU Schofield, BR
Coomes, DL
AF Schofield, BR
Coomes, DL
TI Auditory cortical projections to the cochlear nucleus in guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE descending pathways; efferent; olivocochlear; auditory system
ID DIFFERING SPONTANEOUS RATE; INFERIOR COLLICULUS; IMMUNOCYTOCHEMICAL
CHARACTERIZATION; NERVE FIBERS; CORTEX; RAT; NEURONS; CONNECTIONS;
SYNAPSES; BRANCHES
AB We used anterograde tracing techniques to examine projections from auditory cortex to the cochlear nucleus in guinea pigs. Following injection of dextrans into the temporal cortex, labeled axons were present bilaterally in the cochlear nucleus. The distribution of boutons within the cochlear nucleus was similar on the two sides. The majority of boutons was usually located on the ipsilateral side. Most of the boutons were located in the granule cell areas, where many small boutons and a few larger, mossy-type endings were labeled. Additional small, labeled boutons were found in all layers of the dorsal cochlear nucleus, with the majority located in the fusiform cell layer. Labeled boutons were also present in the ventral cochlear nucleus, where they were located in the small cell cap as well as magnocellular parts of both posteroventral and anteroventral cochlear nucleus. Similar results were obtained with injections restricted to primary auditory cortex or to the dorsocaudal auditory field. The results illustrate direct cortical projections to the cochlear nucleus that are likely to modulate the activity in a number of ascending auditory pathways. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Louisville, Dept Anat Sci & Neurobiol, Louisville, KY 40202 USA.
RP Schofield, BR (reprint author), Univ Louisville, Dept Anat Sci & Neurobiol, 500 S Preston St, Louisville, KY 40202 USA.
EM brscho01@gwise.louisville.edu
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NR 44
TC 37
Z9 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 89
EP 102
DI 10.1016/j.heares.2004.08.003
PG 14
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200009
PM 15574303
ER
PT J
AU Wysocki, J
AF Wysocki, J
TI Topographical anatomy of the guinea pig temporal bone
SO HEARING RESEARCH
LA English
DT Article
DE temporal bone; anatomy; guinea pig
ID COCHLEA
AB Systematic anatomical description of the various structures of the temporal bone have been performed based on dissection of 16 guinea pigs (32 temporal bones). It has been found that besides two main air spaces in the middle ear, the tympanic bulla and dorsal bulla described in literature, there are also additional air cells in the mastoid process and facial nerve region in the temporal bone of a guinea pig. Moreover recesses were found in the walls of the tympanic bulla that formed almost completely separated partitions of tympanic cavity. The malleus head, the body of the incus and the superior and lateral semicircular canals as well as the facial nerve are easily accessible from the dorsal bulla. From the ventral tympanic bulla, one can access both windows and the cochlea. The semicircular canals are relatively large, the lateral canal is largest and the posterior the smallest. The cochlea has thin bony wall, and is composed of 3.5-3.75 turns. (C) 2004 Elsevier B.V. All rights reserved.
C1 Warsaw Univ, Sch Med, Dept Normal Anat, Warsaw, Poland.
RP Wysocki, J (reprint author), Warsaw Univ, Sch Med, Dept Normal Anat, Warsaw, Poland.
EM jwysocki@ib.amwaw.edu.pl
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1994, HOMINA ANATOMICA VET
NR 18
TC 15
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 103
EP 110
DI 10.1016/j.heares.2004.08.008
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200010
PM 15574304
ER
PT J
AU Tokui, N
Suzuki, H
Udaka, T
Hiraki, N
Fujimura, T
Fujimura, K
Makishima, K
AF Tokui, N
Suzuki, H
Udaka, T
Hiraki, N
Fujimura, T
Fujimura, K
Makishima, K
TI Delayed-onset temporary auditor threshold shift following head blow in
guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE sensorineural hearing loss; head injury; head blow device;
disintegration of myelin sheath
ID SPINAL-CORD INJURY; COCHLEAR NERVE; HEARING-LOSS; TRAUMA; SYSTEM;
NEUROTOXICITY; DEMYELINATION; RESPONSES; CULTURES; MICE
AB This study attempts to investigate the development of sensorineural hearing loss following a head blow without skull fracture in association with physiological and histopathologic changes in an experimental animal model.
With the head in a freely movable position, albino guinea pigs were given a single blow to the occipital region by a head blow device. At 1. 7. and 14 days after the blow, the animals' auditory brainstem response (ABR) and cochlear microphonics (CM) were examined, and both the temporal bone and brain stem were observed by light and electron microscopy.
The ABR threshold was unchanged at day 1, was significantly increased at day 7, and was fully recovered at day 14. The I-V and I-II interpeak latencies were significantly prolonged at days I and 7, and wave I latency was significantly prolonged at day 7 only. These latencies were recovered to normal limits at day 14. On the other hand, no significant change in CM versus the control group was observed at any point in the measurements. Histopathologically, no abnormal finding was seen at the light microscopic level. However, at the electron microscopic level, there were some injuries to the eighth nerve. At day 1, the lamellar structure of the myelin sheath was irregular, and the periaxonal space was expanded; at day 7, the myelin sheath was disintegrated. At day 14, however, these changes were partially reversed. These results suggest that sensorineural hearing loss following a head blow in this model is attributed to dysfunction of the eighth nerve rather than to cochlear impairment. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Occupat & Environm Hlth, Dept Otorhinolaryngol, Sch Med, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan.
RP Tokui, N (reprint author), Univ Occupat & Environm Hlth, Dept Otorhinolaryngol, Sch Med, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
EM n-tokui@med.uoeh-u.ac.jp
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NR 31
TC 1
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 111
EP 116
DI 10.1016/j.heares.2004.08.009
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200011
PM 15574305
ER
PT J
AU Gillespie, LN
Marzella, PL
Clark, GA
Crook, JA
AF Gillespie, LN
Marzella, PL
Clark, GA
Crook, JA
TI Netrin-1 as a guidance molecule in the postnatal rat cochlea
SO HEARING RESEARCH
LA English
DT Article
DE spiral ganglion neurons; axon guidance; netrin-1; DCC
ID NEURONS IN-VITRO; CANCER DCC GENE; AUDITORY NEURONS; COLORECTAL-CANCER;
AXON GUIDANCE; INNER-EAR; ELECTRODE ARRAY; NERVOUS-SYSTEM; SPINAL-CORD;
EXPRESSION
AB During synaptogenesis a number of growth factors and peptides control the guidance of auditory neuron (spiral ganglion neuron, SGN) axons to their target cells. Furthermore, evidence suggests that these factors exert their actions at discrete times and sites during development. This study demonstrates that the guidance molecule netrin-1 is expressed in the early postnatal rat cochlea, but shows decreasing expression with increasing age. These results suggest that netrin-1 may be involved in guiding axonal growth from SGNs for the onset of innervation, but is not required for maintenance of synaptic connections. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Melbourne, Eye & Ear Hosp, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
Bion Ear Inst, Melbourne, Vic 3002, Australia.
RP Gillespie, LN (reprint author), Univ Melbourne, Eye & Ear Hosp, Dept Otolaryngol, 2nd Floor, Melbourne, Vic 3002, Australia.
EM lgillespie@bionicear.org
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NR 36
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 117
EP 123
DI 10.1016/j.heares.2004.07.004
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200012
PM 15574306
ER
PT J
AU Sabin, AT
Macpherson, EA
Middlebrooks, JC
AF Sabin, AT
Macpherson, EA
Middlebrooks, JC
TI Human sound localization at near-threshold levels
SO HEARING RESEARCH
LA English
DT Article
DE sound localization; psychoacoustics; spatial coding; auditory cortex
ID PRIMARY AUDITORY-CORTEX; FILTER SHAPES; MEDIAN PLANE; CAT; SENSITIVITY;
NEURONS; LISTENERS; LOCATION; ANGLE
AB Physiological studies of spatial hearing show that the spatial receptive fields of cortical neurons typically are narrow at near-threshold levels, broadening at moderate levels. The apparent loss of neuronal spatial selectivity at increasing sound levels conflicts with the accurate performance of human subjects localizing at moderate sound levels. In the present study, human sound localization was evaluated across a wide range of sensation levels, extending down to the detection threshold. Listeners reported whether they heard each target sound and, if the target was audible, turned their heads to face the apparent source direction. Head orientation was tracked electromagnetically. At near-threshold levels, the lateral (left/right) components of responses were highly variable and slightly biased towards the midline, and front vertical components consistently exhibited a strong bias towards the horizontal plane. Stimulus levels were specified relative to the detection threshold for a front-positioned source, so low-level rear targets often were inaudible. As the sound level increased, first lateral and then vertical localization neared asymptotic levels. The improvement of localization over a range of increasing levels, in which neural spatial receptive fields presumably are broadening, indicates that sound localization does not depend on narrow spatial receptive fields of cortical neurons. (C) 2004 Elsevier B.V. All rights reserved.
C1 Kresge Hearing Res Inst, Cent Syst Lab, Ann Arbor, MI 48109 USA.
RP Middlebrooks, JC (reprint author), Kresge Hearing Res Inst, Cent Syst Lab, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM jmidd@umich.edu
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NR 35
TC 31
Z9 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 124
EP 134
DI 10.1016/j.heares.2004.08.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200013
PM 15574307
ER
PT J
AU Kimitsuki, T
Ohashi, M
Wada, Y
Fukudome, S
Komune, S
AF Kimitsuki, T
Ohashi, M
Wada, Y
Fukudome, S
Komune, S
TI Dissociation enzyme effects on the potassium currents of inner hair
cells isolated from guinea-pig cochlea
SO HEARING RESEARCH
LA English
DT Article
DE inner hair cell; cochlea; potassium current; inactivation; trypsin;
protease VIII; papain
ID ION-DEPENDENT CONDUCTANCES; INACTIVATING BK CHANNELS; CHROMAFFIN CELLS;
FROG; ROD; EXPRESSION; MEMBRANE
AB Tetraethylammonium (TEA)-sensitive potassium currents in the cochlear inner hair cells (IHCs) possess the kinetics of fast inactivation. Some enzymes using for IHCs dissociation affect these inactivation kinetics. IHCs were dissociated from guinea-pig cochlea by I mg/ml trypsin or 0.25 mg/ml protease VIII, and the properties of the K+ currents were compared using conventional whole-cell voltage-clamp recordings. TEA-sensitive potassium currents showed fast inactivation kinetics in both trypsin-dissociated cells and protease VIII-dissociated cells. The time constant of the inactivation phase in trypsin-treated cells was similar to that in protease VIII-treated cells. However, the rate of inactivation (compared by the ratio between the steady-state current and initial peak current) in protease VIII-treated cells was larger than that in trypsin-treated cells. In protease VIII-dissociated cells, the time constant of recovery from inactivation elucidated by paired-pulse protocol was 3.5 ins. Papain is another enzyme that is sometimes used for dissociating IHCs, so effects of papain were observed. Extracellular papain application (8 unit/ml) demonstrated a slight increase of the outward potassium currents. (C) 2004 Elsevier B.V. All rights reserved.
C1 Miyazaki Univ, Miyazaki Med Coll, Dept Otorhinolaryngol, Miyazaki 8891692, Japan.
Khusyu Univ, Dept Otorhinolaryngol, Fac Med, Higashi Ku, Fukuoka 8128582, Japan.
RP Kimitsuki, T (reprint author), Miyazaki Univ, Miyazaki Med Coll, Dept Otorhinolaryngol, 5200 Kihara, Miyazaki 8891692, Japan.
EM kimituki@fc.med.miyazaki-u.ac.jp
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NR 25
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD JAN
PY 2005
VL 199
IS 1-2
BP 135
EP 139
DI 10.1016/j.heares.2004.08.020
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 885RI
UT WOS:000226174200014
PM 15574308
ER
PT J
AU Agaeva, M
AF Agaeva, M
TI Velocity discrimination of auditory image moving in vertical plane
SO HEARING RESEARCH
LA English
DT Article
DE psychoacoustics; moving sound image; differential thresholds to
velocity; vertical plane
ID AUDIBLE MOVEMENT ANGLE; SPECTRAL CUES; DICHOTIC STIMULATION; HORIZONTAL
PLANE; MEDIAN PLANE; SOUND; LOCALIZATION; FREQUENCY; ELEVATION; DURATION
AB This research investigated the ability of humans to discriminate changes in velocity of apparent movement of a sound source (as defined by the time required for the sound to traverse a 180 deg arc) in the median vertical plane. Apparent auditory movement was created by successive switching of the loudspeakers situated over the arc. The broadband noise with band width of 0.25-4 kHz (low-pass noise - LP) and of 4-12.5 kHz (high-pass noise - HP) was employed as stimuli. Discrimination thresholds were calculated for reference velocities of 58 and 115 deg/s under four stimuli types: movement of stepped movement of noise for low-pass noise and for high-pass noise and continuous motion for low-pass noise and for high-pass noise. The result showed that discrimination of the velocity depended on the signal frequency spectrum. The differential thresholds for the signals with low pass noise were significantly higher than those for signals with high pass noise (F(1;78) much greater than 3.96, p < 0.05). Magnitude of the absolute thresholds was the highest when the velocity was It 5 deg/s for each of four types. It is interesting to note that the thresholds magnitude depended on the type of signal motion, that is on whether it was continuous or stepped. (C) 2004 Elsevier B.V. All rights reserved.
C1 Russian Acad Sci, Grp Hearing Physiol, IP Pavlov Physiol Inst, St Petersburg 199034, Russia.
RP Agaeva, M (reprint author), Russian Acad Sci, Grp Hearing Physiol, IP Pavlov Physiol Inst, 6 Makarov Embankment, St Petersburg 199034, Russia.
EM agamu@infran.ru
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NR 23
TC 1
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 1
EP 9
DI 10.1016/j.heares.2004.07.007
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000001
PM 15567597
ER
PT J
AU Stenfelt, S
Hato, N
Goode, RL
AF Stenfelt, S
Hato, N
Goode, RL
TI Round window membrane motion with air conduction and bone conduction
stimulation
SO HEARING RESEARCH
LA English
DT Article
DE round window; vibration pattern; air conduction; bone conduction; middle
ear reconstruction
ID TYMPANIC MEMBRANE; TEMPORAL BONES; PATTERN; EAR
AB The vibration patterns of the round window (RW) membrane in human cadaver temporal bone specimens were assessed by measurements of the velocity of reflective targets placed on the RW membrane with an approximate spacing of 0.2 mm. The velocity was measured in the frequency range 0.1-10 kHz by a laser Doppler vibrometer in four specimens with air conduction (AC) stimulation and in four specimens with bone conduction (BC) stimulation. The response pattern was investigated by analyzing the velocity response of all targets on the RW membrane, by making iso-amplitude and iso-phase contour plots of the membrane surface, and by creating animations of the surface vibration at several frequencies. Similar response pattern was found with AC and BC stimulations. At frequencies below 1.5 kHz, the RW membrane vibrates nearly as a whole in an in-and-out motion and above 1.5 kHz, the membrane moves primarily in two sections that vibrate with approximately 180degrees difference. Indication of some traveling wave motion of the RW membrane at those frequencies was also found. At higher frequencies, above 3 kHz, the membrane motion is complex with a mixture of modal and traveling wave motion. An increase of the stimulation level did not alter the vibration pattern; it only gave an increase of the RW membrane vibration amplitude corresponding to the increase in stimulation. When the mode of stimulation at the oval window was altered, by the insertion of a 0.6 mm piston, the vibration pattern of the RW membrane changed. (C) 2004 Elsevier B.V. All rights reserved.
C1 Chalmers Univ Technol, Dept Signals & Syst, SE-41296 Gothenburg, Sweden.
Stanford Univ, Med Ctr, Div Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA.
RP Stenfelt, S (reprint author), Chalmers Univ Technol, Dept Signals & Syst, SE-41296 Gothenburg, Sweden.
EM stenfelt@s2.chalmers.se
RI Stenfelt, Stefan/J-9363-2013
OI Stenfelt, Stefan/0000-0003-3350-8997
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NR 18
TC 16
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 10
EP 24
DI 10.1016/j.heares.2004.07.008
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000002
PM 15567598
ER
PT J
AU Richardson, RT
Wise, A
O'Leary, S
Hardman, J
Casley, D
Clark, G
AF Richardson, RT
Wise, A
O'Leary, S
Hardman, J
Casley, D
Clark, G
TI Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochlea
SO HEARING RESEARCH
LA English
DT Article
DE neurotrophin-3; I-125; microspheres; cochlea; autoradiography;
sensorineural hearing loss
ID SPIRAL GANGLION NEURONS; RAT SYMPATHETIC NEURONS; AUDITORY NEURONS;
IN-VITRO; COMPARTMENTED CULTURES; RETROGRADE TRANSPORT; PROMOTES
SURVIVAL; NERVOUS-SYSTEM; GENE-TRANSFER; GROWTH-FACTOR
AB Neurotrophin therapy in the cochlea can potentially slow or reverse the degeneration of the auditory nerve that occurs during progressive deafness. Studies were performed to trace the diffusion and uptake of neurotrophin-3 (NT-3) following infusion into the cochlea. NT-3 labeled with I-125 or coated onto fluorescent microspheres was introduced into the basal turn of normal hearing and deafened guinea pig cochleae via a single slow-rate injection. Cochleae were examined between 2 h and 28 days post-infusion by autoradiography or fluorescent microscopy to determine the number of turns labeled by NT-3, identify individual cells and tissues receiving NT-3 and quantify the proportion of signal in each tissue. In general, long-term infusions were required for all cochlear turns to receive NT-3. I-125 NT-3 signal was strongest in cells lining the perilymphatic space of the scala tympani, basilar membrane, osseous spiral lamina and spiral ligament. Signal in the peripheral nerve tract and Rosenthal's canal was only 1.3-2.1 times background levels of radiation. NT-3 microspheres were detected within neural areas of the cochlea (nerve tract and Rosenthal's canal) in all cases, but not within neuronal cell bodies. NT-3 microspheres remained in the cochlea for at least 28 days, suggesting a low clearance rate within cochlear tissues. (C) 2004 Elsevier B.V. All rights reserved.
C1 Bion Ear Inst, Melbourne, Vic 3002, Australia.
Univ Melbourne, Dept Otolaryngol, Melbourne, Vic 3002, Australia.
Univ Melbourne, Dept Med, Austin & Repatriat Med Ctr, Heidelberg, Vic 3084, Australia.
RP Richardson, RT (reprint author), Bion Ear Inst, 384-388 Albert St, Melbourne, Vic 3002, Australia.
EM rrichardson@bionicear.org
RI Wise, Andrew/B-5943-2014
OI Wise, Andrew/0000-0001-9715-8784
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NR 42
TC 18
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 25
EP 35
DI 10.1016/j.heares.2004.02.012
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000003
PM 15567599
ER
PT J
AU Caravelli, A
Pianese, L
Saulino, C
Di Leva, F
Sequino, L
Cocozza, S
Marciano, E
Franze, A
AF Caravelli, A
Pianese, L
Saulino, C
Di Leva, F
Sequino, L
Cocozza, S
Marciano, E
Franze, A
TI Down-regulation of otospiralin mRNA in response to acoustic stress in
guinea pig
SO HEARING RESEARCH
LA English
DT Article
DE otospiralin; mRNA; quantitative RT-PCR; cochlea; gene expression
ID INDUCED HEARING-LOSS; CHICK BASILAR PAPILLA; INNER-EAR PROTEIN;
GENE-EXPRESSION; COCHLEAR ENDOLYMPH; NOISE EXPOSURE; MOUSE COCHLEA;
REAL-TIME; DEAFNESS; MUTATIONS
AB Noise over-stimulation will induce or influence molecular pathways in the cochlea; one approach to the identification of the components of these pathways in the cochlea is to examine genes and proteins that change following different types and levels of stress. Quantitative reverse transcription polymerase chain reaction provides a method to look at differential expression of genes in the acoustic stress response. By using this technique we have revealed a down-regulation of the level of otospiralin mRNA in the cochlea of guinea pigs after white noise over-stimulation for 2 h at 108 dB SPL. Otospiralin represents an inner ear specific protein found in fibrocytes of spiral limbus and spiral ligament in the cochlea, and some regions of the vestibule as the stroma underlying the utricle and crista sensory epithelia and the subepithelial layer of the walls of semicircular canals and maculae. It has been recently reported that transient down-regulation of otospiralin in guinea pigs causes vestibular syndrome and deafness. Our results suggest a possible role of this gene in response to acoustical stress, although the exact mechanism remains to be resolved. (C) 2004 Elsevier B.V. All rights reserved.
C1 IGB, Inst Genet & Biophys, I-80131 Naples, Italy.
Univ Naples Federico 2, Dept Neurosci & Behav Sci, Inst Audiol, Naples, Italy.
SCARL, Biotechnol & Mol Genet, BioGem, Ariano Irpino, Av, Italy.
Univ Naples Federico 2, Dept Biol & Cellular & Mol Pathol, Naples, Italy.
RP Franze, A (reprint author), IGB, Inst Genet & Biophys, A Buzzati Traverso,Via P Castellino 111, I-80131 Naples, Italy.
EM franze@igb.cnr.it
RI Franze', Annamaria/H-2539-2012
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NR 29
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 36
EP 40
DI 10.1016/j.heares.2004.07.011
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000004
PM 15567600
ER
PT J
AU Hirai, S
Harada, T
AF Hirai, S
Harada, T
TI Morphological comparison of apoptotic with non-apoptotic dying cells in
the developing inner ear of mouse embryos
SO HEARING RESEARCH
LA English
DT Article
DE apoptosis; non-apoptotic cell death; inner ear; mouse embryo; TUNEL
method; transmission electron microscopy
ID DEATH; APAF1
AB Dying cells studied by the TdT-mediated dUTP nick end-labeling (TUNEL) method have been classified as "apoptotic" and "non-apoptotic" cells. In this study, in which 12-day-old mouse embryos were used because of a high frequency of "natural cell death" due to changing inner ear morphology [Kaufman, M.H., 1992. The Atlas of Mouse Development, first ed., Academic Press, London, p. 147], the percentages of "apoptotic" and "non-apoptotic" dying cells (ADC and NADC) among total dying cells in the inner ear were calculated. Observation of consecutive paraffin sections showed about 90%) of the dying inner ear cells to be ADC and about 10% to be NADC. ADC and NADC TUNEL positive dying cells in resin sections observed by light microscopy were examined again by transmission electron microscopy using a re-embedding procedure. ADC and NADC were then analyzed based on the classification of dying cells (types 1, 2, 3A, and 3B) as described by Clarke [Anat. Embryol. 181 (1990) 195]. It was clear that ADC were the equivalent of type 1 (apoptotic) dying cells and NADC were the equivalent of type 2 (autophagic) dying cells. We consider these findings to be important baselines for determining the process underlying abnormal development of the inner ear and its functional disorders such as hearing loss. (C) 2004 Published by Elsevier B.V.
C1 Kawasaki Med Univ, Dept Otorhinolaryngol, Kurashiki, Okayama 7010192, Japan.
RP Hirai, S (reprint author), Kawasaki Med Univ, Dept Otorhinolaryngol, 577 Matsushima, Kurashiki, Okayama 7010192, Japan.
EM shigezo@mx1.tiki.ne.jp
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NR 20
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 41
EP 47
DI 10.1016/j.heares.2004.07.012
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000005
PM 15567601
ER
PT J
AU Miller, CA
Robinson, BK
Hetke, JF
Abbas, PJ
Nourski, KV
AF Miller, CA
Robinson, BK
Hetke, JF
Abbas, PJ
Nourski, KV
TI Feasibility of using silicon-substrate recording electrodes within the
auditory nerve
SO HEARING RESEARCH
LA English
DT Article
DE auditory nerve; cat; compound action potential; microelectrode;
neurophysiology; penetrating electrode; peripheral nerve; silicon
ID MONOPOLAR; CAT
AB The use of penetrating, silicon-substrate (i.e., "thin-film") probes within a cross-section of a sensory nerve offers the possibility of assessing the pattern and extent of fiber excitation within the nerve. We used acute cat preparations to assess the feasibility of this technique for recordings within the auditory nerve trunk. Four probe configurations fabricated by the University of Michigan Center for Neural Communication Technology were evaluated using acoustic and electric stimuli. Our main concerns were the nature of the recorded potentials and the degree of spatial selectivity provided by these probes. We also made some basic assessments of electrode-tissue compatibility. The recorded potentials were characterized as field potentials with varying degrees of spatial selectivity. In some cases, responses to pure tones demonstrated good spatial selectivity, with unique responses recorded by different electrode sites. When electrode sites were positioned at different longitudinal positions along the nerve trunk, responses with latencies characteristic of each site were recorded. These results indicate that thin-film electrodes are capable of providing spatially specific response information from sensory nerves. However, in the case of feline auditory nerves, place-specific responses were inconsistently observed, making it difficult to use this technique to obtain detailed cochleotopic maps of neural excitation. More productive results may be possible from other peripheral nerves with less complex spatial arrangements of fibers. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Iowa, Dept Otolaryngol, Iowa City, IA 52242 USA.
Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA.
Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA.
RP Miller, CA (reprint author), Univ Iowa, Dept Otolaryngol, 21201 PFP,200 Hawkins Dr, Iowa City, IA 52242 USA.
EM charles-miller@uiowa.edu
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NR 12
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 48
EP 58
DI 10.1016/j.heares.2004.07.009
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000006
PM 15567602
ER
PT J
AU Oghalai, JS
AF Oghalai, JS
TI Chlorpromazine inhibits cochlear function in guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; electromotility; outer hair cell; cochlear amplifier;
salicylate; chlorpromazine
ID OUTER HAIR CELL; PRODUCT OTOACOUSTIC EMISSIONS; GAP JUNCTIONAL
CONDUCTANCE; BASILAR-MEMBRANE; SUPPORTING CELLS; INNER-EAR;
OLIVOCOCHLEAR ACTIVATION; MAMMALIAN COCHLEA; PLASMA-MEMBRANE; VOLTAGE
SENSOR
AB Outer hair cell (OHC) electromotility provides mechanical positive feedback that functions as the cochlear amplifier. In isolated OHCs, chlorpromazine shifts the electromotility voltage-displacement transfer function in a depolarizing direction without affecting its magnitude. This study sought to measure the effects of chlorpromazine on cochlear function in vivo. Salicylate, a drug that greatly reduces the magnitude of electromotility, was used for comparison. Perilymphatic perfusion of the guinea pig cochlea with chlorpromazine or salicylate increased the compound action potential (CAP) threshold across the frequency spectrum (1-20 kHz). Both drugs also increased distortion product otoacoustic emission (DPOAE) thresholds in the higher frequencies (10-20 kHz). Complete reversibility of these effects occurred after washout. Both drugs demonstrated concentration-dependent reductions in cochlear function that followed sigmoidal curves with similar fits to previously reported results in isolated OHCs. The endolymphatic potential was not affected by either of these drugs. Thus, chlorpromazine inhibits cochlear function in a manner consistent with what would be expected from data in isolated OHCs. This suggests that shifting the electromotility transfer function correspondingly reduces the gain of the cochlear amplifier. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA.
RP Oghalai, JS (reprint author), Baylor Coll Med, Dept Otorhinolaryngol Head & Neck Surg, NA102,1 Baylor Plaza, Houston, TX 77030 USA.
EM jso@bcm.tmc.edu
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NR 65
TC 18
Z9 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 59
EP 68
DI 10.1016/j.heares.2004.03.013
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000007
PM 15567603
ER
PT J
AU Zeftawi, MS
AF Zeftawi, MS
TI MMN to natural Arabic CV syllables: 1-normative data
SO HEARING RESEARCH
LA English
DT Article
DE MMN; Arabic; CV syllables; auditory pathway
ID MISMATCH NEGATIVITY MMN; SPEECH SOUNDS; AUDITORY-DISCRIMINATION; HUMAN
BRAIN; PERCEPTION; REPRESENTATION; CHILDREN; MEMORY; GENERATORS;
POTENTIALS
AB Mismatch negativity response parameters; latency, amplitude, and duration to natural Arabic CV syllables differing in durational change (Baa-Waa) and in spectrotemporal change (Gaa-Daa) were obtained from normal hearing young adult Egyptians. The aim was to get normative data for MMN response parameters and to find any differences between both primary and non-primary auditory pathways in encoding and processing speech signals. Statistically significant differences between durational and spectrotemporal contrasts for latency and duration were found. This was attributed to acoustic differences and to physiological differences between primary and non-primary auditory pathways. (C) 2004 Elsevier B.V. All rights reserved.
C1 Mansoura Gen Hosp, Audiol Unit, Mansoura, Egypt.
RP Zeftawi, MS (reprint author), Mansoura Gen Hosp, Audiol Unit, Mansoura, Egypt.
EM m.samir@medscape.com
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NR 35
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 69
EP 74
DI 10.1016/j.heares.2004.07.003
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000008
ER
PT J
AU Miller, CA
Abbas, PJ
Hay-McCutcheon, MJ
Robinson, BK
Nourski, KV
Jeng, FC
AF Miller, CA
Abbas, PJ
Hay-McCutcheon, MJ
Robinson, BK
Nourski, KV
Jeng, FC
TI Intracochlear and extracochlear ECAPs suggest antidromic action
potentials
SO HEARING RESEARCH
LA English
DT Article
DE auditory nerve; electrical stimulation; cochlear implant; compound
action potential; cat; antidromic
ID COCHLEAR IMPLANT USERS; STIMULATED AUDITORY-NERVE;
ELECTRICAL-STIMULATION; GUINEA-PIG; ELECTRODE CONFIGURATION; EXCITATION
PATTERNS; NEURAL EXCITATION; SPEECH-PERCEPTION; SCALA TYMPANI; MODEL
AB With experimental animals, the electrically evoked compound action potential (ECAP) can be recorded from multiple sites (e.g., round window, intracranial and intracochlear sites). However, human ECAPs are typically recorded from intracochlear electrodes of the implanted array. To bridge this difference, we obtained ECAPs from cats using both intracochlear and nerve-trunk recording sites. We also sought to determine how recording the site influences the acquired evoked potential and how those differences may provide insight into basic excitation properties. In the main experiment, ECAPs were recorded from four acutely deafened cats after implanting a Nucleus-style banded electrode array. Potentials were recorded from an electrode positioned on the nerve trunk and an intracochlear electrode. We manipulated stimulus level, electrode configuration (monopolar vs bipolar) and stimulus polarity, variables that influence the site of excitation. Intracochlear ECAPs were found to be an order of magnitude greater than those obtained with the nerve-trunk electrode. Also, compared with the nerve-trunk potentials, the intracochlear ECAPs more closely resembled those obtained from humans in that latencies were shorter and the waveform morphology was typically biphasic (a negative peak followed by a positive peak). With anodic monophasic stimuli, the ECAP had a unique positive-to-negative morphology which we attributed to antidromic action potentials resulting from a relatively central site of excitation. We also collected intracochlear ECAPs from twenty Nucleus 24 implant users. Compared with the feline ECAPs, the human potentials had smaller amplitudes and longer latencies. It is not clear what underlies these differences, although several factors are considered. (C) 2004 Published by Elsevier B.V.
C1 Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA.
RP Miller, CA (reprint author), Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 21201 PFP,200 Hawkins Dr, Iowa City, IA 52242 USA.
EM charles-miller@uiowa.edu
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NR 35
TC 24
Z9 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 75
EP 86
DI 10.1016/j.heares.2004.07.005
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000009
PM 15567605
ER
PT J
AU Khalfa, S
Bruneau, N
Roge, B
Georgieff, N
Veuillet, E
Adrien, JL
Barthelemy, C
Collet, L
AF Khalfa, S
Bruneau, N
Roge, B
Georgieff, N
Veuillet, E
Adrien, JL
Barthelemy, C
Collet, L
TI Increased perception of loudness in autism
SO HEARING RESEARCH
LA English
DT Article
DE autism; auditory dynamic range; loudness; hyperacusis
ID CHILDHOOD AUTISM; FOLLOW-UP; DYSFUNCTION; CHILDREN
AB Clinical reports on autism describe abnormal responses to auditory stimuli such as intolerance to sounds. The present study assessed subjective perception of loudness in subjects with autism compared to healthy controls, using two psychoacoustic tests. First, the auditory dynamic range was evaluated at six different tone frequencies. Secondly, loudness growth as a function of the intensity level of a 1 kHz tone was estimated. Verbal responses from a group of 11 children and adolescents with autism were compared to responses of 11 age- and gender- matched healthy controls. Smaller auditory dynamic ranges were found in the autistic group than in the control group, as well as increased perception of loudness, indicating hyperacusis in subjects with autism. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Mediterranee, INSERM, EMI U 9926, Fac Med Timone,Lab Neurophysiol & Neuropsychol, F-13385 Marseille 5, France.
CHU Bretonneau, INSERM, U619, Serv Neurophysiol Pedopsychiat,IFR 135, F-37044 Tours, France.
Univ Toulouse Le Mirail, UFR Psychol, F-31058 Toulouse 1, France.
ITTAC, F-69616 Villeurbanne, France.
Hop Edouard Herriot, CNRS, UMR 5020, F-69003 Lyon, France.
Univ Paris 05, Lab Psychol Clin Psychopathol, F-75270 Paris 06, France.
RP Khalfa, S (reprint author), Univ Mediterranee, INSERM, EMI U 9926, Fac Med Timone,Lab Neurophysiol & Neuropsychol, 27 Bd Jean Moulin, F-13385 Marseille 5, France.
EM skhalfa@skhalfa.com
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NR 25
TC 56
Z9 59
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 87
EP 92
DI 10.1016/j.heares.2004.07.006
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000010
PM 15617227
ER
PT J
AU Young, YH
Kuo, SW
AF Young, YH
Kuo, SW
TI Side-difference of vestibular evoked myogenic potentials in healthy
subjects
SO HEARING RESEARCH
LA English
DT Article
DE binaural acoustic stimulation; side-difference; vestibular evoked
myogenic potential; relative amplitude; interaural amplitude difference
ratio
ID REFLEX; CATS; NEURONS
AB The aim of this study was to investigate the side-difference of vestibular evoked myogenic potentials (VEMPs) in relation to the provocation rates, latencies and amplitudes using binaural acoustic stimulation with bilateral recording. Fourteen healthy volunteers underwent a serial VEMP testings elicited binaurally by a sequence of alternating stimulus intensities, that is, 95-95 (right-left), 85-95, 95-85, and 85-85 dBHL tone burst, respectively. The provocation rates as well as the mean latencies of p13 and n23 for the VEMPs demonstrated no significant side-difference despite using 95-95, 85-95, 95-85 and 85-85 dBHL binaural acoustic stimulation. In contrast, nine (64%) of the 14 subjects showed side-difference of absolute p13-n23 amplitude, including right side dominant in five subjects, and left side dominant in four subjects. However, there was no significant side-difference in terms of relative amplitude despite using 95-95, 85-95, 95-85 and 85-85 dBHL binaural acoustic stimulation. Furthermore, the relative amplitude or interaural amplitude difference (IAD) ratios between those with and without side-difference of p13-n23 amplitude did not differ significantly. Hence, this study provides a potentially important method for adjusting the side difference of p13-n23 amplitudes by using a relative amplitude or IAD ratio adjustment. It also adds confidence to the successful use of binaural stimulation and recording of VEMPs under conditions of bilateral SCM muscular contractions. (C) 2004 Elsevier B.V. All rights reserved.
C1 Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan.
Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
Far Eastern Mem Hosp, Dept Otolaryngol, Taipei, Taiwan.
RP Young, YH (reprint author), Natl Taiwan Univ Hosp, Dept Otolaryngol, 1 Chang Te St, Taipei, Taiwan.
EM youngyh@ha.mc.ntu.edu.tw
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NR 15
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 93
EP 98
DI 10.1016/j.heares.2004.06.011
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000011
PM 15567606
ER
PT J
AU Munirathinam, S
Ostapoff, EM
Gross, J
Kempe, GS
Dutton, JA
Morest, DK
AF Munirathinam, S
Ostapoff, EM
Gross, J
Kempe, GS
Dutton, JA
Morest, DK
TI Organization of inhibitory feed-forward synapses from the dorsal to the
ventral cochlear nucleus in the cat: a quantitative analysis of endings
by vesicle morphology
SO HEARING RESEARCH
LA English
DT Article
DE synaptic morphometry; vesicle morphology; convolution filters; imaging;
tuberculo-ventral tract; axonal tracers; auditory center/surround; local
circuits; temporal processing
ID BRAIN-STEM; GUINEA-PIG; SYNAPTIC ORGANIZATION; AUDITORY-SYSTEM; SINGLE
UNITS; BUSHY CELLS; D-ASPARTATE; GLYCINE; PROJECTIONS; NEURONS
AB The main ascending, excitatory pathway from the cochlea undergoes synaptic interruption in the dorsal and ventral cochlear nuclei. The dorsal cochlear nucleus also forms a feed-forward circuit, which receives cochlear input and projects to the ventral cochlear nucleus by a tuberculo-ventral tract. This circuit may provide an inhibitory fringe (side bands) surrounding the center bands of the main ascending pathway. Biotinylated dextran injections into the dorsal cochlear nucleus anterogradely labeled the tuberculo-ventral tract and its endings in the anteroventral cochlear nucleus but also retrogradely filled cochlear nerve fibers and their terminals in the same regions. To distinguish tuberculo-ventral from cochlear nerve terminals, we used electron microscopy of the immunolabeled endings. Images were digitized and filter-enhanced, and the sizes and shapes of synaptic vesicles were used to construct quantitative profiles of the terminal types. The cochlear nerve endbulbs mapped to the same iso-frequency band of the injection site (main band). Flanking the main band were smaller labeled endings. About 45% of labeled terminals were pleomorphic and equally represented in the main band and side bands. Therefore, if there is an inhibitory fringe in the main projection pathway, it was not selective for tuberculo-ventral tract endings. Surprisingly, an excitatory category of round vesicles of intermediate size was labeled in the main band but not in the side bands. These intermediate endings may balance the feed-forward inhibition from the tuberculo-ventral tract. The quantitative method devised for classification of ending types by their vesicle profiles should be a generally useful tool for analysis. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Connecticut, Ctr Hlth, Dept Neurosci, Ctr Neurol Sci, Farmington, CT 06030 USA.
RP Morest, DK (reprint author), Univ Connecticut, Ctr Hlth, Dept Neurosci, Ctr Neurol Sci, Farmington, CT 06030 USA.
EM kent@neuron.uchc.edu
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NR 54
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 99
EP 115
DI 10.1016/j.heares.2004.06.007
PG 17
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000012
PM 15567607
ER
PT J
AU Recanzone, GH
Beckerman, NS
AF Recanzone, GH
Beckerman, NS
TI Effects of intensity and location on sound location discrimination in
macaque monkeys
SO HEARING RESEARCH
LA English
DT Article
DE macaque; sound; localization; intensity
ID PRIMARY AUDITORY-CORTEX; OLD-WORLD MONKEYS; LOCALIZATION BEHAVIOR;
RECEPTIVE-FIELDS; CORTICAL-NEURONS; CAT; FREQUENCY; PRIMATES;
REPRESENTATION; SENSITIVITY
AB Sound localization performance is degraded at low stimulus intensities in humans, and while the sound localization ability of humans and macaque monkeys appears similar, the effects of intensity have yet to be described in the macaque. We therefore defined the ability of four macaque monkeys to localize broadband noise stimuli at four different absolute intensities and six different starting locations in azimuth. Results indicate that performance was poorest at the lowest intensity tested (25 dB SPL), intermediate at 35 dB SPL, and equivalent at 55 and 75 dB SPL. Localization performance was best at 0degrees (directly in front of the animal) and was systematically degraded at more peripheral locations (+/-30degrees and 90degrees) and worst at a location directly behind the animal. Reaction times showed the same trends, with reaction times increasing with decreasing stimulus intensity, even under conditions where the monkey discriminated the location change with the same performance. These results indicate that sound level as well as position profoundly influences sound localization ability. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA.
Univ Calif Davis, Sect Neurobiol Physiol & Behav, Davis, CA 95616 USA.
RP Recanzone, GH (reprint author), Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA.
EM ghrecanzone@ucdavis.edu
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NR 25
TC 22
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 116
EP 124
DI 10.1016/j.heares.2004.07.017
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000013
PM 15567608
ER
PT J
AU Jerger, J
Martin, J
AF Jerger, J
Martin, J
TI Hemispheric asymmetry of the right ear advantage in dichotic listening
SO HEARING RESEARCH
LA English
DT Article
DE dichotic listening; interaural asymmetry; interhemispheric asymmetry;
right-ear advantage; structural model; attentional model
ID PERIPHERAL AUDITORY LATERALIZATION; EVENT-RELATED POTENTIALS;
OTOACOUSTIC EMISSIONS; SELECTIVE ATTENTION; HEARING SENSITIVITY;
DIRECTED ATTENTION; CHILDREN; STIMULI; WAVE; REA
AB ERP waveforms evoked by target-right and target-left stimuli in a directed-attention, dichotic-listening paradigm were examined using cross-correlation analysis. We analyzed data from two experiments involving linguistic processing. They involved listening for (1) a phonemic feature, and (2) a series of morpho-syntactic anomalies. The maximum correlation between target-right and target-left waveforms was achieved when the target-right waveform was delayed relative to the target-left waveform (the T shift), reflecting the shorter latency of the target-right waveform. We interpret the direction of displacement as equivalent to a "right-ear advantage" in the dichotic listening paradigm. In both tasks, tau shifts were not uniformly distributed across the parietal electrode array. They were greatest on the extreme left side of the head and systematically declined as the electrode site moved rightward, indicating a temporal gradient in the relative latencies of the two waveforms. Results are interpreted in relation to both structural and attentional aspects of dichotic listening. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Texas, Sch Behav & Brain Sci, Texas Auditory Proc Disorder Lab, Richardson, TX 75080 USA.
RP Jerger, J (reprint author), Univ Texas, Sch Behav & Brain Sci, Texas Auditory Proc Disorder Lab, 2612 Prairie Creek Dr E, Richardson, TX 75080 USA.
EM jjerger@utdallas.edu
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NR 66
TC 21
Z9 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 125
EP 136
DI 10.1016/j.heares.2004.07.019
PG 12
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000014
PM 15567609
ER
PT J
AU Minami, SB
Sha, SH
Schacht, J
AF Minami, SB
Sha, SH
Schacht, J
TI Antioxidant protection in a new animal model of cisplatin-induced
ototoxicity
SO HEARING RESEARCH
LA English
DT Article
DE hearing loss; salicylate; reactive oxygen species
ID SQUAMOUS-CELL CARCINOMA; 4-METHYLTHIOBENZOIC ACID; SODIUM THIOSULFATE;
DOSE CISPLATIN; GUINEA-PIGS; CHEMOTHERAPY; CANCER; SALICYLATE; RAT;
RADIOTHERAPY
AB Mortality is a major complication in animal models of cisplatin-induced hearing loss due to the systemic toxicity of the drug. Here we report on a novel two-cycle treatment in rats, each cycle consisting of four days of cisplatin injections (1 mg/kg, i.p., twice daily) separated by 10 days of rest. This regimen, similar to clinical courses of cancer chemotherapy, produced significant hearing loss without mortality. Auditory brain stem evoked responses were unchanged after the first cycle but were elevated by 40-50 dB at 16 and 20 kHz after the second. Loss of outer hair cells occurred after the second cycle, predominantly in the base of the cochlea. Total cochlear antioxidants declined progressively during drug treatment and were reduced to 60% of control values after the second cisplatin cycle. Co-administration of salicylate (100 mg/kg, s.c., twice daily) during both cycles or during the second cycle restored antioxidant levels and reduced cisplatin-induced threshold shifts.
This model of cisplatin ototoxicity without mortality eliminates potentially confounding factors that may determine the survival of a special cohort of animals. The results also support the notion that reactive oxygen species are involved in cisplatin ototoxicity and show the potential usefulness of antioxidant treatment. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Keio Univ, Dept Otolaryngol, Tokyo 160, Japan.
RP Schacht, J (reprint author), Univ Michigan, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109 USA.
EM schacht@umich.edu
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NR 37
TC 36
Z9 44
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD DEC
PY 2004
VL 198
IS 1-2
BP 137
EP 143
DI 10.1016/j.heares.2004.07.016
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 878IK
UT WOS:000225640000015
PM 15567610
ER
PT J
AU Viberg, A
Canlon, B
AF Viberg, A
Canlon, B
TI The guide to plotting a cochleogram
SO HEARING RESEARCH
LA English
DT Article
DE auditory; basilar membrane; frequency-place maps; hearing loss
ID AUDITORY-NERVE FIBERS; HAIR CELL-DENSITY; GUINEA-PIG; BASILAR-MEMBRANE;
HOUSE-MOUSE; SPIRAL GANGLION; RAT COCHLEA; FREQUENCY; ORGAN; CORTI
AB The cochleogram is commonly used for illustrating hair cell loss after insult, yet standardized procedures for plotting either individual or averaged cochleograms are lacking despite more than 40 years of use. Due to the intra-species variation in basilar membrane (BM) length, it is important that length is plotted on the cochleogram in percent and not millimeter. It is also of interest to correlate the location of lesion to frequency by using a frequency-place equation. However, there is no consensus as which equation is most suitable for the species under study. This is an important issue since two different equations can result in significantly different frequency-place maps for the same cochlea. The purpose of this presentation is to suggest procedures for standardizing the cochleogram. The guidelines include: (i) basilar membrane length should be plotted as percent instead of millimeter due to the biological variation that exists in BM length within a particular species and strain, and the total length in millimeter stated on the cochleogram; (ii) the equations used for frequency-place maps should be stated on the cochleogram; (iii) different basilar membrane lengths should be normalized to percent before averaged cochleograms are made. These procedures are illustrated and discussed. (C) 2004 Published by Elsevier B.V.
C1 Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
RP Canlon, B (reprint author), Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
EM barbara.canlon@fyfa.ki.se
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NR 28
TC 64
Z9 68
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 1
EP 10
DI 10.1016/j.heares.2004.04.016
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800001
PM 15504598
ER
PT J
AU Corbacella, E
Lanzoni, I
Ding, DL
Previati, M
Salvi, R
AF Corbacella, E
Lanzoni, I
Ding, DL
Previati, M
Salvi, R
TI Minocycline attenuates gentamicin induced hair cell loss in neonatal
cochlear cultures
SO HEARING RESEARCH
LA English
DT Article
DE gentamicin; ototoxicity; hair cells; minocycline; cytochrome c;
apoptosis
ID AMINOGLYCOSIDE INDUCED OTOTOXICITY; CYTOCHROME-C RELEASE; GUINEA-PIG;
INDUCED APOPTOSIS; CASPASE ACTIVATION; PROTECTS COCHLEAR; DEATH
RECEPTOR; ELEGANS CED-4; IN-VITRO; ANTIBIOTICS
AB Minocycline, a second-generation tetracycline antibiotic used against gram-negative and gram-positive bacteria, protects against a wide range of neurodegenerative disorders by inhibiting caspases, NOS and the release of cytochrome c. Since aminoglycoside antibiotics damage sensory hair cells in the inner ear by activating caspase-mediated cell death pathways, we hypothesized that minocycline would protect against gentamicin (GM) ototoxicity. To test this hypothesis, postnatal day 3 (P3) rat, cochlear organotypic cultures were treated with GM alone or in combination with minocycline (10-500 muM). Treatment with GM induced a dose-dependent loss of outer hair cells (OHC) and inner hair cells (IHC). Addition of minocycline to the GM-treated cultures greatly reduced the amount of GM-induced hair cell damage in P3 cochlear cultures. The greatest protection was achieved with 100 muM of minocycline. Application of minocycline alone had no adverse effects on hair cell survival. The advantage of this combination therapy is that minocycline prevents GM-induced hair cell loss while helping to suppress the bacterial infection. (C) 2004 Published by Elsevier B.V.
C1 SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
Univ Ferrara, Human Anat Sect, I-44100 Ferrara, Italy.
Univ Ferrara, Dept Audiol, I-44100 Ferrara, Italy.
RP Salvi, R (reprint author), SUNY Buffalo, Dept Commun Disorders & Sci, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
EM salvi@buffalo.edu
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NR 42
TC 37
Z9 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 11
EP 18
DI 10.1016/j.heares.2004.03.012
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800002
PM 15504599
ER
PT J
AU Shi, GZ
Gong, LX
Xu, XH
Nie, WY
Lin, Q
Qi, YS
AF Shi, GZ
Gong, LX
Xu, XH
Nie, WY
Lin, Q
Qi, YS
TI GJB2 gene mutations in newborns with non-syndromic hearing impairment in
Northern China
SO HEARING RESEARCH
LA English
DT Article
DE bilateral hearing loss; neonatal screening; hearing tests; mutation;
GJB2 gene
ID CONNEXIN 26 GENE; SENSORINEURAL DEAFNESS; PREVALENCE; JAPANESE;
CHILDREN; POPULATION; FAMILY
AB Mutations in GJB2 account for the majority of recessive forms of prelingual hearing loss. However, in most previous studies it was not possible to distinguish between congenital (present at birth) and non-congenital prelingual hearing loss. In the present study, the frequency of GJB2 alleles in 20 newborns with bilateral severe-to-profound non-syndromic hearing impairment (NSHI) who were found at birth through newborn hearing screening and clinical examination is reported. PCR was used to amplify the coding region of GJB2 gene followed by sequencing analyses. Fifty volunteers with normal hearing were included as controls. Results showed that three cases were 235delC/235delC homozygotes; one was 235delC/605ins46 compound heterozygotes, 605ins46 mutation was a novel mutation reported in the Chinese population; another was 235delC/299-300delAT compound heterozygotes. 25% (5/20) of the deafness in newborns studied was caused by GJB2 gene mutations. The frequency of 235delC allele carrier in patients and in control group was 22.5% and 1%, respectively. One case was identified as being a 235delC heterozygote without other mutations detected. Besides, multiple polymorphisms such as V27I, V37I, E114G, T123N were also detected. In conclusion, GJB2 analysis is an important test that identifies a major cause of newborns with bilateral severe-to-profound NSHI screened by universal newborn hearing screening in Northern China. The most common pathologic mutation of GJB2 in studied cases was 235delC. Molecular analysis and genetic counseling will be extremely important for congenital deafness present at birth. (C) 2004 Elsevier B.V. All rights reserved.
C1 Shantou Univ, Coll Med, Dept Forens Med, Shantou 515031, Guangdong, Peoples R China.
Jinan Matern & Child Care Hosp, Shandong 250001, Peoples R China.
RP Shi, GZ (reprint author), Shantou Univ, Coll Med, Dept Forens Med, 22 Xinling Rd, Shantou 515031, Guangdong, Peoples R China.
EM laurelshi@yahoo.com.cn
CR Abe S, 2000, J MED GENET, V37, P41, DOI 10.1136/jmg.37.1.41
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NR 30
TC 27
Z9 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 19
EP 23
DI 10.1016/j.heares.2004.06.012
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800003
PM 15504600
ER
PT J
AU Kondrachuk, AV
Wiederhold, ML
AF Kondrachuk, AV
Wiederhold, ML
TI On generation of statoconia in gravireceptors of mollusks
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 22nd Annual International Gravitational Physiology Meeting
CY APR 22-27, 2001
CL Budapest, HUNGARY
DE model; statoconia; statocyst; mollusks; statoconia growth; rate of
growth
ID BIOMPHALARIA-GLABRATA PULMONATA; STATOCYST; BASOMMATOPHORA
AB Two models of development of statoconia in the statocyst of mollusks, based on the experimental data [Hearing Res. 49 (1990) 63; Hearing Res. 109 (1997) 125; Hearing Res. 109 (1997) 109] are proposed. The purpose of the present work is to apply mathematical modeling to the analysis of mechanisms of statoconia formation and generation by supporting cells at the stage of their accumulation in the cyst lumen. In the case of Aplysia californica, it is not clear whether there is a temporal change of statoconia, due to their growth in the cyst lumen similar to that in Biomphalaria, or whether the growth of statoconia, occurs in supporting cells before they get into the cyst lumen. This question has to do with a more general and insufficiently investigated problem of the mechanisms of statoconia evolution during their stage of accumulation. This is related to A. californica as well as to the initial phase of development of Biomphalaria glabrata. This problem is of practical importance because the majority of experiments related to the study of the effects of altered gravity on the development of gravireceptors in the two mollusks A. californica and B. glabrata deals with the initial phase of statoconia development. It is assumed that two main processes determine the evolution of statoconia in developing mollusks: generation of new statoconia, by growing supporting cells and growth of statoconia sizes in the cyst lumen. Analysis of experimental data related to the generation of statoconia in Aplysia and comparison of these data with the results of modeling of accumulation of statoconia, suggest that the basic mechanism of evolution of size distribution of statoconia in Aplysia is growth of embryonic statoconia in supporting cells, that follows the growth of animal size. Thus, the large sizes of statoconia are determined by their development within supporting cells rather than by their growth in the cyst lumen. Analysis of the data concerning Biomphalaria allows us to assume that distribution of supporting cells which generate statoconia also varies. The results of modeling of evolution of statoconia specify necessary additional experiments, which are required to refine and test the model. (C) 2004 Elsevier B.V. All rights reserved.
C1 Natl Acad Sci Ukraine, Inst Phys, Dept Theoret Phys, UA-252143 Kiev, Ukraine.
Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78229 USA.
RP Kondrachuk, AV (reprint author), Natl Acad Sci Ukraine, Inst Phys, Dept Theoret Phys, Zabolotny St 154, UA-252143 Kiev, Ukraine.
EM kondr@kondr.kiev.ua
CR Gao WY, 1997, HEARING RES, V109, P109, DOI 10.1016/S0378-5955(97)00058-0
Gao WY, 1997, HEARING RES, V109, P125, DOI 10.1016/S0378-5955(97)00059-2
Kondrachuk AV, 2001, HEARING RES, V154, P1, DOI 10.1016/S0378-5955(00)00185-4
KONDRACHUK AV, 2001, J GRAVITATIONAL PHYS, V8, P109
WIEDERHOLD ML, 1990, HEARING RES, V49, P63, DOI 10.1016/0378-5955(90)90095-7
NR 5
TC 1
Z9 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 24
EP 34
DI 10.1016/j.heares.2004.06.001
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800004
PM 15504601
ER
PT J
AU Liu, X
Mohamed, JA
Ruan, RS
AF Liu, X
Mohamed, JA
Ruan, RS
TI Analysis of differential gene expression in the cochlea and kidney of
mouse by cDNA microarrays
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; kidney; microarray; hearing; mouse
ID QUIET-AGED GERBILS; INNER-EAR; NA,K-ATPASE ACTIVITY; MAMMALIAN COCHLEA;
MESSENGER-RNA; LATERAL WALL; HEARING-LOSS; HAIR-CELLS; LOCALIZATION;
DEAFNESS
AB Microarray hybridization analysis of gene expression in the cochlea and kidney suggest a relationship between these tissues at the genomic level, indicating the common gene expression, likely serving a common function in both the organs primarily maintaining ion transport, and implied previously from morphological, pharmaco-kinetic and teratogenic studies. The cDNAs of more than 100 genes listed on the hereditary hearing loss homepage were amplified as targets by RT-PCR and were hybridized with probes prepared from total RNA of the cochlea and the kidney. Thirteen of the genes analyzed showed altered fluorescence ratios of more than two logs. Of these, the expressions of I I genes were over expressed and two were under expressed in the cochlea than in the kidney. Our data is the first report to corroborate the genomic similarities between these two important organs and may help to explain the somewhat similar response of these organs to certain therapeutic drugs. (C) 2004 Elsevier B.V. All rights reserved.
C1 Natl Univ Singapore Hosp, Dept Otolaryngol, Singapore 117548, Singapore.
Univ Texas, Hlth Sci Ctr, Dept Internal Med, Houston, TX 77030 USA.
RP Ruan, RS (reprint author), Natl Univ Singapore Hosp, Dept Otolaryngol, Main Bldg,Level 3, Singapore 117548, Singapore.
EM entrrs@nus.edu.sg
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NR 44
TC 7
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 35
EP 43
DI 10.1016/j.heares.2004.04.014
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800005
PM 15504602
ER
PT J
AU van Ruijven, MWM
de Groot, JCMJ
Smoorenburg, GF
AF van Ruijven, MWM
de Groot, JCMJ
Smoorenburg, GF
TI Time sequence of degeneration pattern in the guinea pig cochlea during
cisplatin administration. A quantitative histological study
SO HEARING RESEARCH
LA English
DT Article
DE cisplatin ototoxicity; guinea pig; cochlea; stria vascularis; spiral
ganglion; organ of Corti; degeneration pattern
ID STRIA VASCULARIS; SPIRAL GANGLION; INDUCED OTOTOXICITY; CIS-PLATINUM;
INNER-EAR; SEMIQUANTITATIVE ANALYSIS; ADENYLATE-CYCLASE; ALBINO;
RECOVERY; MORPHOLOGY
AB We investigated the key tissues that are implicated in cisplatin ototoxicity within the time window during which degeneration starts. Guinea pigs were treated with cisplatin at a dose of 2 mg/kg/day for either 4, 6, or 8 consecutive days. Histological changes in the organ of Corti, the stria vascularis and the spiral ganglion were quantified at the light microscopical level. Outer hair cell (OHC) loss started between 4 and 6 days of cisplatin administration, but is only significantly different from the non-treated group after 8 days of treatment. Midmodiolar OHC counts were comparable to the cytocochleogram data. The cross-sectional area of the stria vascularis did not differ from the non-treated group, nor did an endolymphatic hydrops develop during the course of treatment. Spiral ganglion cell (SGC) densities did not decrease. After 6 days, however, detachment of the myelin sheath of the type-I SGCs was seen in the lower basal turn, whereas after 8 days it was also present in the more apically located turns. Myelin sheath detachment is the result of perikaryal shrinkage and swelling of the myelin sheath. The present study confirms that cisplatin at a daily dose of 2 mg/kg has a detrimental effect on the OHCs as well as on the type-I SGCs. These intracochlear effects occur simultaneously; OHC loss and SGC shrinkage start between the fourth and sixth day of cisplatin administration and appear to develop in parallel. At this dose, no histological effect on the stria vascularis could be observed, although previous electrophysiological experiments demonstrated a clear effect on the endocochlear potential [NeuroReport 11, 623 Hear. Res. 164, 138]. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Utrecht, Med Ctr, Dept Otorhinolaryngol, Hearing Res Labs, NL-3508 GA Utrecht, Netherlands.
RP van Ruijven, MWM (reprint author), Univ Utrecht, Med Ctr, Dept Otorhinolaryngol, Hearing Res Labs, Room G-02-531,POB 85-500, NL-3508 GA Utrecht, Netherlands.
EM m.vanruijven@kmb.azu.nl
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NR 51
TC 35
Z9 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 44
EP 54
DI 10.1016/j.heares.2004.07.014
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800006
PM 15504603
ER
PT J
AU Gabriel, D
Veuillet, E
Ragot, R
Schwartz, D
Ducorps, A
Norena, A
Durrant, JD
Bonmartin, A
Cotton, F
Collet, L
AF Gabriel, D
Veuillet, E
Ragot, R
Schwartz, D
Ducorps, A
Norena, A
Durrant, JD
Bonmartin, A
Cotton, F
Collet, L
TI Effect of stimulus frequency and stimulation site on the N1m response of
the human auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE tonotopy; magnetoencephalography; asymmetry; high frequencies
ID EVOKED MAGNETIC-FIELDS; DIPOLE MODEL ANALYSIS; TONOTOPIC ORGANIZATION;
RIGHT-HEMISPHERE; HUMAN-BRAIN; COMPONENT; WAVE; REPRESENTATION;
TRANSIENT; SYSTEM
AB The aim of the present study was to investigate the functional organization of the auditory cortex for pure tones of 1, 2, 4, 6, 8 and 12 kHz. Ten subjects were tested with a whole-head magnetometer (151 channels). The location, latency and amplitude of the generators of the N1m (the main component of the response, peaking approximately at 100 ms) were explored simultaneously in the right and left hemispheres under monaural stimulation. Our results revealed that tonotopy is a rather complex functional organization of the auditory cortex. From I to 12 kHz, tonotopic maps were found for contralateral as well as for ipsilateral stimulation: N1m generators were found to be tonotopically organized mainly in an anterior-posterior direction in both hemispheres, whatever the stimulated ear, but also in an inferior-superior direction in the right hemisphere. Furthermore, latencies were longer in the left than in the right hemisphere. Two different representations of spectral distribution were found in the right auditory cortex: one for ipsilateral and one for contralateral stimulation. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Lyon 1, CNRS, GDR 2213, Lab Neurosci & Syst Sensoriels,UMR 5020, F-69366 Lyon 07, France.
Hop La Pitie Salpetriere, CNRS, UPR 640, LENA, F-75651 Paris, France.
Ctr Hosp Lyon Sud, Unite RMN, F-69495 Pierre Benite, France.
RP Gabriel, D (reprint author), Univ Lyon 1, CNRS, GDR 2213, Lab Neurosci & Syst Sensoriels,UMR 5020, 50 Av Tony Garnier, F-69366 Lyon 07, France.
EM damiengabriel@yahoo.fr
RI cotton, francois/F-4762-2013
OI cotton, francois/0000-0003-0046-2478
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NR 41
TC 17
Z9 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 55
EP 64
DI 10.1016/j.heares.2004.07.015
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800007
PM 15504604
ER
PT J
AU Stjernschantz, J
Wentzel, P
Rask-Andersen, H
AF Stjernschantz, J
Wentzel, P
Rask-Andersen, H
TI Localization of prostanoid receptors and cyclo-oxygenase enzymes in
guinea pig and human cochlea
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; guinea pig; man; prostanoid receptors; cyclo-oxygenase;
immunohistochemistry
ID PROSTAGLANDIN SYNTHESIS; SALICYLATE; EXPRESSION; QUININE; CELLS
AB Endogenous production of prostaglandins has been demonstrated in the cochlea, but no information is available on the distribution of the cyclo-oxygenase (COX) enzymes, or prostanoid receptors in the cochlea. The purpose of the present study was to investigate the localization of the FP, EP1 and EP3 prostanoid receptors as well as the COX-1 and COX-2 enzymes in the cochlea of guinea pig and man. Cochleas were processed for immunohistochemistry using routine techniques. Appropriate controls comprised incubation with specific blocking peptides, or incubation without primary antibodies. Both in guinea pig and man the FP prostanoid receptor was abundantly distributed in the cochlea, e.g., in stria vascularis, the spiral ligament, spiral ganglion, and organ of Corti. The immunohistochemical staining of the EP1 and EP3 receptors in the same structures was significantly weaker and sometimes lacking altogether (e.g., EP3 receptor in human cochlea). Weak, but mostly consistent immunostaining of the COX-1 enzyme was found in the cochlear structures. The COX-2 enzyme appeared to be lacking. The abundant distribution of the FP receptor in several important cochlear structures both in guinea pig and man suggests a physiological function for PGF(2alpha) in the cochlea. The COX-1 enzyme seems to be constitutively expressed in the cochlea in contrast to COX-2. (C) 2004 Elsevier B.V. All rights reserved.
C1 Uppsala Univ, Pharmacol Unit, Dept Neurosci, SE-75124 Uppsala, Sweden.
Uppsala Univ, Unit Otolaryngol & Head & Neck Surg, Dept Surg Sci, SE-75124 Uppsala, Sweden.
RP Stjernschantz, J (reprint author), Uppsala Univ, Pharmacol Unit, Dept Neurosci, SE-75124 Uppsala, Sweden.
EM johan.stjernschantz@neuro.uu.se
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NR 21
TC 12
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 65
EP 73
DI 10.1016/j.heares.2004.04.018
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800008
PM 15504605
ER
PT J
AU Firzlaff, U
Schuller, G
AF Firzlaff, U
Schuller, G
TI Directionality of hearing in two CF/FM bats, Pteronotus parnellii and
Rhinolophus rouxi
SO HEARING RESEARCH
LA English
DT Article
DE head-related transfer function; spatial hearing; pinna; microchiroptera
ID SOUND PRESSURE TRANSFORMATION; LEAF-NOSED BATS; BIG BROWN BAT; CONSTANT
FREQUENCY BATS; RUFOUS HORSESHOE BAT; CF-FM BAT; CAROLLIA-PERSPICILLATA;
EPTESICUS-FUSCUS; AUDITORY-CORTEX; SPECTRAL CUES
AB The head-related transfer function (HRTF) has been measured in two CF/FM bats, Pteronotus parnellii and Rhinolophus rouxi from 575 positions in the frontal hemisphere. P. parnellii showed an increase of the elevation angle of the axis of highest pinna gain with increasing frequency followed by a specific decrease at 75 kHz. Such a drop of elevation angle of the acoustic axis was not seen in R. rouxi. The HRTF further showed a spectral notch dependent on elevation and frequency in P. parnellii, but not in R. rouxi. The functional implications of this difference between both bat species are discussed. Frequencies at maximum pinna gain values did not clearly match the frequencies of the harmonics of the echolocation calls whereas spatial resolution of interaural intensity differences was best in a frequency range that included the higher harmonics of the echolocation calls in both bat species. However, specializations of HRTF patterns matching the exact frequencies of the harmonics of the echolocation calls could not be observed in both bat species. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Munich, Dept Biol 2, D-82152 Planegg Martinsried, Germany.
RP Firzlaff, U (reprint author), Univ Munich, Dept Biol 2, Grosshadernerstr 2, D-82152 Planegg Martinsried, Germany.
EM firzlaff@zi.biologie.uni-muenchen.de
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NR 49
TC 17
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 74
EP 86
DI 10.1016/j.heares.2004.06.009
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800009
PM 15504606
ER
PT J
AU Wei, CG
Cao, KL
Zeng, FG
AF Wei, CG
Cao, KL
Zeng, FG
TI Mandarin tone recognition in cochlear-implant subjects
SO HEARING RESEARCH
LA English
DT Article
DE cochlear implant; tone recognition; speech recognition; rate
discrimination; electrode; channel
ID INTERLEAVED SAMPLING PROCESSORS; SPEECH RECOGNITION; TEMPORAL CUES;
FUNDAMENTAL-FREQUENCY; ELECTRIC HEARING; ENVELOPE CUES; PERCEPTION;
CHINESE; PITCH; INFORMATION
AB This study examined tone recognition in five cochlear-implant subjects who were native speakers of Mandarin and used a Nucleus-22 device. Psychophysical experiments were conduced to measure rate discrimination in individual electrodes from the most apical to the most basal electrodes. The rate range was from 100 to 200 Hz, which corresponded to the range of variation in fundamental frequency for the tonal tokens used in this study. Speech recognition experiments were also conducted to measure tone recognition as function of the number of electrodes from a 1-electrode map to a 20-electrode map. Large individual variability was observed for both rate discrimination and tone recognition result: Average rate discrimination ranged between 0.2 and 1.2 (Weber's fraction) whereas tone recognition ranged between 30% and 70% correct. A highly significant correlation was found between rate discrimination and tone recognition with the 20-electrode map, but a non-significant correlation was observed with the 1-electrode map due to a floor effect in tone recognition. The present result supports the hypothesis that both spectral and temporal cues contribute to tone recognition. In addition, the present result shows that current cochlear-implant subjects produced significantly lower performance than acoustic simulations in normal-hearing subjects, suggesting that neither temporal nor spectral cues have been adequately and appropriately extracted and encoded in current cochlear implants. New designs are discussed to improve tone recognition in cochlear implant subjects. (C) 2004 Elsevier B.V. All rights reserved.
C1 Beijing Union Med Coll Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China.
Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA.
Univ Calif Irvine, Dept Biomed Engn Head & Neck Surg, Irvine, CA 92697 USA.
Univ Calif Irvine, Dept Cognit Sci & Otolaryngol, Irvine, CA 92697 USA.
RP Zeng, FG (reprint author), Beijing Union Med Coll Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China.
EM fzeng@uci.edu
RI Zeng, Fan-Gang/G-4875-2012
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NR 46
TC 51
Z9 62
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 87
EP 95
DI 10.1016/j.heares.2004.06.002
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800010
PM 15504607
ER
PT J
AU Cotton, J
Grant, W
AF Cotton, J
Grant, W
TI Computational models of hair cell bundle mechanics: I. Single
stereocilium
SO HEARING RESEARCH
LA English
DT Article
DE stereocilia computational model; stereocilia deformation; actin shear
deformation
ID ACTIN-FILAMENTS; SENSORY HAIRS; INNER-EAR; MECHANOELECTRICAL
TRANSDUCTION; RECEPTOR CELLS; STIFFNESS; COCHLEA
AB A distributed parameter model for describing the response of a stereocilium to an applied force is presented. This model is based on elasticity theory, plus the geometry and material properties of the stereocilium. The stereocilia shaft above the taper is not assumed to be perfectly rigid. It is assumed to be deformable and that two separate mechanisms are involved in its deformation: bending and shear. The influence of each mode of deformation is explored in parametric studies. Results show that the magnitude of tip deflection depends on the shear compliance of the stereocilium material, the degree of base taper, and stereocilium height. Furthermore, the deformation profiles observed experimentally will occur only if there are constraints on the geometry and material properties of the stereocilium. (C) 2004 Elsevier B.V. All rights reserved.
C1 Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA.
Virginia Polytech Inst & State Univ, Sch Biomed Engn & Sci, Blacksburg, VA 24061 USA.
RP Grant, W (reprint author), Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Mail Code 0219, Blacksburg, VA 24061 USA.
EM jgrant@vt.edu
RI Cotton, John/H-6302-2011
OI Cotton, John/0000-0003-4029-2565
CR Beer F. P., 2001, MECH MAT
BORESI AP, 1993, ADV MECH MAT, P178
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NR 24
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 96
EP 104
DI 10.1016/j.heares.2004.06.004
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800011
PM 15504608
ER
PT J
AU Cotton, J
Grant, W
AF Cotton, J
Grant, W
TI Computational models of hair cell bundle mechanics: II. Simplified
bundle models
SO HEARING RESEARCH
LA English
DT Article
DE hair cell bundle; mechanical model; bundle stiffness; distributed
parameter bundle model
ID INNER-EAR; CILIARY BUNDLES; STIFFNESS; COCHLEA
AB Simplified versions of hair cell bundles are mechanically modeled. The influence of various geometric and material combinations on bundle stiffness, link tensions and deformation shape are examined; Three models are analyzed within this paper: two stereocilia connected by one link, two stereocilia connected by a biologically realistic set of links, and a column of stereocilia connected by realistic links. Stereocilia are modeled using a distributed parameter model [J.Biomech.Eng. 122, 44]. Some fundamental rules for linking bundles emerge from these tests: (1) Links must have a threshold stiffness value for the bundle to deform as a whole. Beyond this value, the stereocilia are perfectly linked and variations in link stiffness do not significantly effect the bundle stiffness or link tension. (2) Decreasing the relative heights of successive stereocilia may increase link tension while decreasing bundle stiffness. (3) When lateral links exist, the top most lateral links carry the majority of tension. Lower links in single column model appear mechanically insignificant. (4) Extending the length of the bundle in a column does not increase the stiffness once the column reaches a certain length. (C) 2004 Elsevier B.V. All rights reserved.
C1 Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA.
Virginia Polytech Inst & State Univ, Sch Biomed Engn & Sci, Blacksburg, VA 24061 USA.
RP Grant, W (reprint author), Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Mail Code 0219, Blacksburg, VA 24061 USA.
EM jgrant@vt.edu
RI Cotton, John/H-6302-2011
OI Cotton, John/0000-0003-4029-2565
CR Beer F. P., 2001, MECH MAT
COREY D P, 1989, Society for Neuroscience Abstracts, V15, P208
COTTON JR, 1998, THESIS VIRGINIA POLY
COTTON JR, 1997, ANAL FINITE ELEMENT
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Duncan RK, 1997, HEARING RES, V104, P15, DOI 10.1016/S0378-5955(96)00176-1
Duncan RK, 1995, AUDIT NEUROSCI, V1, P321
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Tsuprun V, 2000, JARO, V1, P224, DOI 10.1007/s101620010010
NR 19
TC 14
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 105
EP 111
DI 10.1016/j.heares.2004.06.005
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800012
PM 15504609
ER
PT J
AU Silber, J
Cotton, J
Nam, JH
Peterson, EH
Grant, W
AF Silber, J
Cotton, J
Nam, JH
Peterson, EH
Grant, W
TI Computational models of hair cell bundle mechanics: III. 3-D utricular
bundles
SO HEARING RESEARCH
LA English
DT Article
DE finite element bundle model; 3-D hair cell bundle model; tip-link
tensions; upper lateral link tensions
ID MECHANOELECTRICAL TRANSDUCTION; FLEXURAL RIGIDITY; CILIARY BUNDLES; TIP
LINKS; INNER-EAR; MICROTUBULES; STEREOCILIA; ADAPTATION; FROG
AB Six utricular hair bundles from a red-eared turtle are modeled using 3-D finite element analysis. The mechanical model includes shear deformable stereocilia, realignment of all forces during force load increments, and tip and lateral link inter-stereocilia connections. Results show that there are two distinct bundle types that can be separated by mechanical bundle stiffness. The more compliant group has fewer total stereocilia and short stereocilia relative to kinocilium height; these cells are located in the medial and lateral extrastriola. The stiff group are located in the striola. They have more stereocilia and long stereocilia relative to kinocilia heights. Tip link tensions show parallel behavior in peripheral columns of the bundle and serial behavior in central columns when the tip link modulus is near or above that of collagen (1x10(9) N/m(2)). This analysis shows that lumped parameter models of single stereocilia columns can show some aspects of bundle mechanics; however, a distributed, 3-D model is needed to explore overall bundle behavior. (C) 2004 Elsevier B.V. All rights reserved.
C1 Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA.
Virginia Polytech Inst & State Univ, Sch Biomed Engn & Sci, Blacksburg, VA 24061 USA.
Virginia Polytech Inst & State Univ, Dept Mech Engn, Blacksburg, VA 24061 USA.
Ohio Univ, Dept Sci Biol, Athens, OH 45701 USA.
Ohio Univ, Program Neurosci, Athens, OH 45701 USA.
RP Grant, W (reprint author), Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Mail Code 0219, Blacksburg, VA 24061 USA.
EM jgrant@vt.edu
RI Cotton, John/H-6302-2011
OI Cotton, John/0000-0003-4029-2565
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NR 33
TC 26
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 112
EP 130
DI 10.1016/j.heares.2004.06.006
PG 19
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800013
PM 15504610
ER
PT J
AU Chen, ZQ
Ulfendahl, M
Ruan, RS
Tan, L
Duan, ML
AF Chen, ZQ
Ulfendahl, M
Ruan, RS
Tan, L
Duan, ML
TI Protection of auditory function against noise trauma with local
caroverine administration in guinea pigs
SO HEARING RESEARCH
LA English
DT Article
DE caroverine; glutamate receptor antagonist; protection; noise-induced
hearing loss; auditory brainstem response; guinea pig
ID EXCITATORY AMINO-ACIDS; INDUCED HEARING-LOSS; RECEPTOR SUBUNITS;
MAMMALIAN COCHLEA; KAINIC ACID; INNER-EAR; EXCITOTOXICITY; ASPARTATE;
SYNAPSES; NEURONS
AB Glutamate is the most likely neurotransmitter at the synapse between the inner hair cell and its afferent neuron in the peripheral auditory system. Intense noise exposure may result in excessive glutamate release, binding to the post-synaptic receptors and leading to neuronal degeneration and hearing impairment. The present study investigated the protective effect of caroverine, an antagonist of two glutamate receptors, N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, on noise-induced hearing loss. Two different doses of caroverine were applied onto the round window membrane with gelfoam, followed by one-third-octave band noise centered at 6.3 kHz (110 dB SPL) for 1h. Auditory brainstem responses were measured at regular time intervals afterwards. Caroverine was found to offer significant protection of the cochlear function against noise-induced hearing loss. (C) 2004 Elsevier B.V. All rights reserved.
C1 Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
Natl Univ Singapore, Dept Otolaryngol, Singapore, Singapore.
Karolinska Hosp, Karolinska Inst, Ctr Hearing & Commun Res, SE-17176 Stockholm, Sweden.
Karolinska Hosp, Dept Otolaryngol, S-10401 Stockholm, Sweden.
RP Duan, ML (reprint author), Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
EM maoli.duan@cfh.ki.se
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NR 38
TC 7
Z9 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD NOV
PY 2004
VL 197
IS 1-2
BP 131
EP 136
DI 10.1016/j.heares.2004.03.021
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 871JH
UT WOS:000225126800014
PM 15504611
ER
PT J
AU Szucs, A
Szappanos, H
Toth, A
Farkas, Z
Panyi, G
Csernoch, L
Sziklai, I
AF Szucs, A
Szappanos, H
Toth, A
Farkas, Z
Panyi, G
Csernoch, L
Sziklai, I
TI Differential expression of purinergic receptor subtypes in the outer
hair cells of the guinea pig
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 40th Workshop on Inner Ear Biology
CY SEP 07-10, 2003
CL Granada, SPAIN
DE OHC; purinoceptors; ATP; calcium
ID 5'-TRIPHOSPHATE-GATED ION-CHANNEL; DEVELOPING RAT COCHLEA; P2X
RECEPTORS; ATP RECEPTOR; MUSCLE CELLS; ELECTROMOTILITY; ACETYLCHOLINE;
LOCALIZATION; SUBUNITS; NOMENCLATURE
AB ATP acts as a neuro-modulator through purinoceptors in many different tissues. Many subtypes of these receptors have been identified in the inner ear, but so far only two types have been shown to be present in the membrane of the isolated outer hair cells (OHCs). The aim of this study was to detect and visualize the existence and distribution of purinoceptor subtypes as well as to study the [Ca2+](i) response of these cells in response to stimulation with ATP. Four P2X and three P2Y receptor subtypes were identified with different expression pattern in the membrane of guinea pig outer hair cells. Whereas intense labeling was observed for P2X1, P2X2, P2X4, P2Y1, P2Y2, and P2Y4, the labeling for the subtype P2X7 was weak. There was a marked difference in the distribution of the receptors along the surface of the cells with a homogenous distribution in cases of P2X I, P2X4, and P2Y1. In contrast, P2X2 and P2Y2 receptor density was high mainly at the apical, while P2X7 and P2Y4 at the basal pole of the cells. Similarly a heterogeneity was observed in the ATP-induced transient elevation in [Ca2+](i), which had either fast kinetics without desensitization or slow rise with desensitization. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Debrecen, Sch Med, Med & Hlth Sci Ctr, Dept Otolaryngol & Head & Neck Surg, H-4012 Debrecen, Hungary.
Univ Debrecen, Med Sch, Med & Hlth Sci Ctr, Dept Physiol, Debrecen, Hungary.
Univ Debrecen, Med Sch, Med & Hlth Sci Ctr, Dept Biophys & Cell Biol, Debrecen, Hungary.
Univ Debrecen, Med Sch, Med & Hlth Sci Ctr, Cell Physiol Res Grp, Debrecen, Hungary.
RP Szucs, A (reprint author), Univ Debrecen, Sch Med, Med & Hlth Sci Ctr, Dept Otolaryngol & Head & Neck Surg, H-4012 Debrecen, Hungary.
EM aszucs10@hotmail.com
RI Cserne Szappanos, Henrietta/A-3216-2009; Panyi, Gyorgy/H-4406-2013
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NR 29
TC 18
Z9 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 2
EP 7
DI 10.1016/j.heares.2004.04.008
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700002
PM 15464295
ER
PT J
AU Previati, M
Lanzoni, I
Corbacella, E
Magosso, S
Giuffre, S
Francioso, F
Arcelli, D
Volinia, S
Barbieri, A
Hatzopoulos, S
Capitani, S
Martini, A
AF Previati, M
Lanzoni, I
Corbacella, E
Magosso, S
Giuffre, S
Francioso, F
Arcelli, D
Volinia, S
Barbieri, A
Hatzopoulos, S
Capitani, S
Martini, A
TI RNA expression induced by cisplatin in an organ of Corti-derived
immortalized cell line
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 40th Workshop on Inner Ear Biology
CY SEP 07-10, 2003
CL Granada, SPAIN
ID HEP G2 CELLS; DIHYDRORHODAMINE 123; LIPID-PEROXIDATION;
ARACHIDONIC-ACID; CIS-PLATINUM; HEARING-LOSS; APOPTOSIS; CYTOTOXICITY;
OTOTOXICITY; GENERATION
AB Cisplatin [civ-diamminedichloroplatinum(II)] (CDDP) is an organic compound that is widely used for the treatment of a large number of tumors. Its clinical use is limited by the presence of some undesired side effects, like as oto- and nephro toxicity, whose mechanisms of action are not understood. One of the possible CDDP toxicity mechanism seems to involve the generation of reactive oxygen species (ROS), that can impair morphology and function of hair cells (HQ in the organ of Corti.
To test this hypothesis we evaluated the effect of CDDP treatment on RNA steady-state levels of 15,000 genes by microarray analysis, using, as a experimental model, the OC-k3 cell line, obtained from the organ of Corti of transgenic mice and constitutively expressing the large SV40 T antigen. We have found overexpression of several genes related to arachidonate mobilization including phospholipase A2, group IV and V, phospholipase A2 activating protein and lysophospholipase I and 111, as well as lipoxygenation like arachidonate 12-lipoxygenase and arachidonate 5-lipoxygenase activating protein. In addition, we found significant transcription of genes regulating cell respiration, including cyt c oxidase, as well as genes involved in xenobiotic detoxification and lipid peroxidation such as cyt P450, and other oxidases including spermine oxidase and monoamine oxidase.
As a whole, overexpression of the group of different genes seems to indicate that an oxidative burst could take place during cisplatin administration. We therefore searched for evidences of superoxide anion and hydrogen peroxide by means of electron paramagnetic resonance (EPR) spectroscopy and flow cytometry, but failed to detect them. On the other hand, we found an increase of malondialdehyde (MDA) synthesis and protein carbonylation products, indicating the occurence of lipid peroxidative degradation. When we tested the effectiveness of butylated hydroxytoluene (BHT), dithiothreitol (DTT) and N-acetylcysteine (N-Ac) as cytoprotectants, all of them reduced protein carbonylation to control levels and significantly protected OC-k3 from CDDP-induced cell death, with an higher protection when using the lipophylic antioxidant BHT. The same antioxidants prevented also the onset of protein carbonylation, which extent was decreased to basal levels.
These data indicate that CDDP is able to stimulate gene expression up to 12 h after the beginning of the treatment. This increase in gene transcription involves a large number of genes potentially able to increase the level of cell ROS. Consistently, cells survival is improved by cotreatment with antioxidants, in particular lipophilics. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Ferrara, Human Anat Div, Dept Morphol & Embryol, I-44100 Ferrara, Italy.
Univ Ferrara, Ctr Bioacust, Ferrara, Italy.
Univ Ferrara, Histol Div, Dept Morphol & Embryol, Ferrara, Italy.
CNR, ISOF, Ferrara, Italy.
RP Previati, M (reprint author), Univ Ferrara, Human Anat Div, Dept Morphol & Embryol, Via Fossato Mortara 66, I-44100 Ferrara, Italy.
EM prm@unife.it
RI Barbieri, Andrea/B-8712-2009
OI Barbieri, Andrea/0000-0002-8841-9521
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NR 37
TC 14
Z9 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 8
EP 18
DI 10.1016/j.heares.2004.04.009
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700003
PM 15464296
ER
PT J
AU Varela-Nieto, I
Morales-Garcia, JA
Vigil, P
Diaz-Casares, A
Gorospe, I
Sanchez-Galiano, S
Canon, S
Camarero, G
Contreras, J
Cediel, R
Leon, Y
AF Varela-Nieto, I
Morales-Garcia, JA
Vigil, P
Diaz-Casares, A
Gorospe, I
Sanchez-Galiano, S
Canon, S
Camarero, G
Contreras, J
Cediel, R
Leon, Y
TI Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 40th Workshop on Inner Ear Biology
CY SEP 07-10, 2003
CL Granada, SPAIN
DE apoptosis; insulin-like growth factors; cochleovestibular ganglion;
development; IGF-I deficit; neurodegeneration; neuroprotection; otic
vesicle
ID CELL-PROLIFERATION; TRANSGENIC MICE; AUDITORY-SYSTEM; NERVOUS-SYSTEM;
CHICK-EMBRYO; OTIC NEURONS; HAIR-CELLS; GENE; EXPRESSION;
INSULIN-LIKE-GROWTH-FACTOR-1
AB lnsulin-like growth factors (IGFs) have a pivotal role during nervous system development and in its functional maintenance. IGF-I and its high affinity receptor (IGF1R) are expressed in the developing inner ear and in the postnatal cochlear and vestibular ganglia. We recently showed that trophic support by IGF-I is essential for the early neurogenesis of the chick cochleovestibular ganglion (CVG). In the chicken embryo otic vesicle, IGF-I regulates developmental death dynamics by regulating the activity and/or levels of key intracellular molecules, including lipid and protein kinases such as ceramide kinase, Akt and Jun N-terminal kinase (JNK). Mice lacking IGF-I lose many auditory neurons and present increased auditory thresholds at early postnatal ages. Neuronal loss associated to IGF-I deficiency is caused by apoptosis of the auditory neurons, which presented abnormally increased levels of activated caspase-3. It is worth noting that in man, homozygous deletion of the IGF-I gene causes sensory-neural deafness (reviewed in Rev. Endo. Met. Disord. 3 (2002) 357). IGF-I is thus necessary for normal development and maintenance of the inner ear. The trophic actio, is of IGF-I in the inner car suggest that this factor may have therapeutic potential for the treatment of hearing loss. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed Alberto Sols, Madrid 28029, Spain.
Univ Complutense Madrid, Fac Vet, Madrid 28040, Spain.
Univ Autonoma Madrid, Dept Biol Fisiol Anim, Madrid, Spain.
RP Varela-Nieto, I (reprint author), Univ Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed Alberto Sols, Arturo Duperier 4, Madrid 28029, Spain.
EM ivarela@iib.uam.es
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NR 43
TC 32
Z9 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 19
EP 25
DI 10.1016/j.heares.2003.12.022
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700004
PM 15464297
ER
PT J
AU Soto, A
Labella, T
Santos, S
del Rio, M
Lirola, A
Cabanas, E
Elhendi, W
AF Soto, A
Labella, T
Santos, S
del Rio, M
Lirola, A
Cabanas, E
Elhendi, W
TI The usefulness of computerized dynamic posturography for the study of
equilibrium in patients with Meniere's disease: correlation with
clinical and audiologic data
SO HEARING RESEARCH
LA English
DT Article; Proceedings Paper
CT 40th Workshop on Inner Ear Biology
CY SEP 07-10, 2003
CL Granada, SPAIN
DE Meniere's disease; posturography; staging
ID PAROXYSMAL POSITIONAL VERTIGO; POSTURAL CONTROL; PLATFORM POSTUROGRAPHY;
DIZZINESS; HANDICAP
AB The use of computerized dynamic posturogaphy (CDP) in the evaluation of patients with balance alterations not only allows quantification of the subject's capacity to maintain a stable centre of gravity, but also analysis of the degree to which the subject is able to use different types of sensory information. The present study investigated the possible use of CDP for clinical staging of vestibular diseases, specifically Meniere's disease (MD). We applied CDP sensory organization tests to 75 patients with definitive MD (AAO-HNS 1995 criteria). A total of 98 CDP sessions were included in the analysis, which focused on four CDP parameters specifically related to vestibular function (condition-5 score, condition-6 score, overall balance score, and VEST, a measure of the relative importance of vestibular information for maintenance of balance). We found a statistically significant relationship between audiometric hearing threshold and CDP scores, especially in patients with audiometrically advanced disease. In addition, CDP scores showed statistically significant variation with time elapsed since the last typical vertigo attack, suggesting that patients can be usefully grouped into three MD activity-level categories: recent post-attack (less than I week since last vertigo attack), late post-attack (1 week - 60 days since last attack), and inactive MD (more than 60 days since last attack). On the basis of these results, we propose expected ranges for each of the four CDP parameters in each of the three MD activity-level categories, allowing staging in terms of balance and posture. This staging system complements existing staging systems (based on audiometric criteria, and on subjective assessment of the severity of vertigo attacks and their implications for quality of life). (C) 2004 Elsevier B.V. All rights reserved.
C1 Sch Med, Santiago De Compostela, Spain.
RP Soto, A (reprint author), Clin Hosp, Dept Otolaryngol, Santiago De Compostela, Spain.
EM ciandsot@usc.es
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NR 22
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 26
EP 32
DI 10.1016/j.heares.2004.06.010
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700005
PM 15464298
ER
PT J
AU Ahn, SH
Oh, SH
Lee, JS
Jeong, JM
Lim, D
Lee, DS
Kim, CS
AF Ahn, SH
Oh, SH
Lee, JS
Jeong, JM
Lim, D
Lee, DS
Kim, CS
TI Changes of 2-deoxyglucose uptake in the rat auditory pathway after
bilateral ablation of the cochlea
SO HEARING RESEARCH
LA English
DT Article
DE deaf; 2-deoxyglucose; auditory cortex; glucose metabolism; cross-modal
plasticity
ID CROSS-MODAL PLASTICITY; INFERIOR COLLICULUS; IMAGE REGISTRATION;
SPEECH-PERCEPTION; IMPLANTATION; CORTEX; PATTERNS; THALAMUS; CHILDREN;
SYSTEM
AB It has been reported that the area of decreased glucose metabolism in the FDG-PET of prelingually deaf children correlates significantly with speech performance after cochlear implantation. In this study, we undertook to confirm changes of glucose metabolism in the cerebral cortex using an animal model with age-matching groups to completely exclude the influence of age differences between the deaf and normal-hearing groups.
The cochlea was ablated bilaterally at a postnatal 10-14 days in the deaf groups; 3-4 deaf and normal rats were included at each time point at 1, 2, 4 and 8 weeks and 7 months after ablation. After injecting 2-deoxyglucose intraperitoneally, digitalized auto-radiographic images were obtained, and analyzed by using two different methods; 3-dimensional voxel-wise statistical analysis and conventional 2-dimensional densitometry. The hypometabolic area analyzed using 3-dimensional analysis and the differences of optical density between normal and deaf as determined by densitometry were widest and most prominent between 4 and 8 weeks after ablation. Differences were not significant before 2 weeks or after 7 months after ablation.
This result shows that the hypometabolic area becomes prominent after a critical period and it decreases as the duration of deafness increases. We believe that cross-modal plasticity may be the mechanism of changes in glucose metabolism and that this result reinforced the usefulness of evaluating hypometabolic area using FDG-PET in deaf children. (C) 2004 Elsevier B.V. All rights reserved.
C1 Seoul Natl Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul 110744, South Korea.
Seoul Natl Univ, Coll Med, Dept Nucl Med, Seoul, South Korea.
RP Kim, CS (reprint author), Seoul Natl Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, 28 Yongon Dong, Seoul 110744, South Korea.
EM chongkim@plaza.snu.ac.kr
RI Jeong, Jae Min/E-2102-2012; Lee, Dong Soo/J-2778-2012; Lee, Jae
Sung/J-2781-2012
OI Jeong, Jae Min/0000-0003-2611-6020;
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NR 25
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 33
EP 38
DI 10.1016/j.heares.2004.05.012
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700006
PM 15464299
ER
PT J
AU Kitahara, T
Li, HS
Balaban, CD
AF Kitahara, T
Li, HS
Balaban, CD
TI Localization of the mitochondrial uncoupling protein family in the rat
inner ear
SO HEARING RESEARCH
LA English
DT Article
DE uncoupling protein; PGC-1 alpha; PPAR gamma; vestibular ganglion; spiral
ganglion; mitochondria; real-time PCR; immunohistochemistry
ID CALORIC NYSTAGMUS; VESTIBULAR-NERVE; 3-DIMENSIONAL ASPECTS;
ENERGY-METABOLISM; SQUIRREL-MONKEY; CELLS; EXPRESSION; BRAIN; MICE;
THERMOGENESIS
AB Uncoupling proteins (UCPs) are a proton transporter family located in the mitochondrial inner membrane. The molecular expression and activity of UCPs in brown adipose tissue and skeletal muscle are regulated by factors as diverse as chronic overeating and cold exposure,. suggesting roles in energy expenditure and heat production. Although UCP2, UCP4 and brain mitochondrial carrier proteir-1 (BMCP-1, i.e. UCP5) mRNAs are expressed in the central nervous system, their central function is unknown. This study presents the first evidence on localization and quantitative expression of UCPs in the rat inner ear by real-time PCR and immunohistochemistry. Real-time PCR studies revealed that UCP2 mRNA was expressed in the vestibular and spiral ganglia more abundantly than any other UCP. Neocortex, by contrast, contained UCP2 and UCP4 equally. Notably, UCP3 and UCP4 mRNAs were expressed in inner ear ganglia, but brain UCP3 mRNA expression level was undetectable by simple PCR. Immunohistochemical studies confirmed that both UCP2- and UCP3-like immunoreactivities were detected in vestibular and spiral ganglion cells and co-localized with a mitochondrial marker, MitoFluorGreen. According to previous reports, UCP2 and UCP3 are thermogenic in yeast and train UCP2 has been suggested to modulate pre- and post-synaptic events by axonal thermogenesis. It has also been reported recently that UCP2 and UCP3 responses to superoxide application may be an antioxidant protective mechanism. Therefore, it is suggested that mitochondrial UCPs (UCP2, UCP3, UCP4) may play both a protective role against oxidative damage and a thermal signaling role in the eighth nerve. (C) 2004 Published by Elsevier B.V.
C1 Univ Pittsburgh, Sch Med, Dept Otolaryngol, Eye & Ear Inst 107, Pittsburgh, PA 15123 USA.
Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15123 USA.
Univ Pittsburgh, Sch Med, Dept Commun Sci, Pittsburgh, PA 15123 USA.
RP Balaban, CD (reprint author), Univ Pittsburgh, Sch Med, Dept Otolaryngol, Eye & Ear Inst 107, 203 Lothrop St, Pittsburgh, PA 15123 USA.
EM balabancd@pitt.edu
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NR 36
TC 10
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 39
EP 48
DI 10.1016/j.heares.2004.02.002
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700007
PM 15464300
ER
PT J
AU Baumann, U
Nobbe, A
AF Baumann, U
Nobbe, A
TI Pulse rate discrimination with deeply inserted electrode arrays
SO HEARING RESEARCH
LA English
DT Article
DE temporal pitch; electric hearing; cochlear implant; frequency
discrimination
ID COCHLEAR IMPLANT SUBJECTS; FREQUENCY DISCRIMINATION; PITCH PERCEPTION;
ELECTRICAL-STIMULATION; TEMPORAL PITCH; HEARING-LOSS; MODULATION; TONES;
SENSITIVITY; LISTENERS
AB Pulse rate difference limen (PRDL) and amplitude modulation difference limen (AMDL) were assessed as a function of base rate and cochlear electrode location in seven (three for AMDL) subjects implanted with the MED-EL COMBI 40+ implant. The MEDEL COMBI 40+ electrode array allows deep insertion of the electrode up to the apex of the cochlea to minimize the rate/place mismatch for pulse rates below 500 pps. A three interval, two alternative forced-choice procedure with feedback was used to measure the difference limen. The base rate was in the range between 200 and 800 pps. The carrier rate for the AMDL measurement was 5081 pps. The PRDL increased with increasing base pulse rate. At 200 pps the average PRDL measured at the apical electrode amounted to 48.7 pps, at 400 pps the average PRDL reached 206.6 pps. No significant difference between PRDL obtained from apical or basal electrodes could be observed. AMDL was higher than PRDL at all tested base rates. The ability to discriminate rate changes is limited to base rates up to about 283 pps. The results indicate that rate changes smaller than a major third do not elicit distinguishable auditory perceptions in electrical hearing. The absence of a difference between apical and basal electrode locations indicates that a reduction of the rate/place mismatch does not improve discrimination performance. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Munich, Dept Otorhinolaryngol, D-81377 Munich, Germany.
RP Baumann, U (reprint author), Univ Munich, Dept Otorhinolaryngol, Marchioninistr 15, D-81377 Munich, Germany.
EM uwe.baumann@med.uni-muenchen.de
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NR 35
TC 22
Z9 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 49
EP 57
DI 10.1016/j.heares.2004.06.008
PG 9
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700008
PM 15464301
ER
PT J
AU Takemura, K
Komeda, M
Yagi, M
Himeno, C
Izumikawa, M
Doi, T
Kuriyama, H
Miller, JM
Yamashita, T
AF Takemura, K
Komeda, M
Yagi, M
Himeno, C
Izumikawa, M
Doi, T
Kuriyama, H
Miller, JM
Yamashita, T
TI Direct inner ear infusion of dexamethasone attenuates noise-induced
trauma in guinea pig
SO HEARING RESEARCH
LA English
DT Article
DE steroid; drug delivery system; noise-induced hearing loss; cochlea;
guinea pig; osmotic pump; auditory brainstem response
ID INDUCED HEARING-LOSS; COCHLEAR BLOOD-FLOW; HAIR CELL LOSS; LASER DOPPLER
MEASUREMENTS; NITRIC-OXIDE SYNTHASE; ACOUSTIC TRAUMA; GLUCOCORTICOID
RECEPTORS; NEUROTROPHIC FACTOR; LIPID-PEROXIDATION; AMINOGLYCOSIDE
OTOTOXICITY
AB The protective effect of dexamethasone (DEX) against noise-induced trauma, as reflected in hair cell destruction and elevation in auditory brainstem response (ABR) sensitivity, was assessed in guinea pigs. The animals were administered DEX (1, 10, 100, and 1000 ng/ml) or artificial perilymph (AP) via a mini-osmotic pump directly into scala tympani and, on the fourth day after pump implantation, exposed to 120 dB SPL octave band noise, centered at 4 kHz, for 24 h. Animals receiving DEX demonstrated a dose-dependent reduction in noise-induced outer hair cell loss (significant at 1, 10 and 100 ng/ml DEX animals compared to AP control animals) and a similar attenuation of the noise-induced ABR threshold shifts, observed 7 days following exposure (significant at 100 ng/ml DEX animals compared to AP control animals). These physiological and morphological results indicate that direct infusion of DEX into the perilymphatic space has protective effects against noise-induced trauma in the guinea pig cochlea. (C) 2004 Elsevier B.V. All rights reserved.
C1 Kansai Med Univ, Dept Otolaryngol, Moriguchi, Osaka 5708507, Japan.
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA.
Karolinska Inst, Dept Otolaryngol, Stockholm, Sweden.
RP Takemura, K (reprint author), Kansai Med Univ, Dept Otolaryngol, Fumizono Cho 10-15, Moriguchi, Osaka 5708507, Japan.
EM takemura@takii.kmu.ac.jp
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NR 91
TC 74
Z9 77
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 58
EP 68
DI 10.1016/j.heares.2004.06.003
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700009
PM 15464302
ER
PT J
AU Yang, WP
Henderson, D
Hu, BH
Nicotera, TM
AF Yang, WP
Henderson, D
Hu, BH
Nicotera, TM
TI Quantitative analysis of apoptotic and necrotic outer hair cells after
exposure to different levels of continuous noise
SO HEARING RESEARCH
LA English
DT Article
DE apoptosis; necrosis; outer hair cell; noise; chinchilla
ID GUINEA-PIG; CHINCHILLA COCHLEA; INTENSE NOISE; IMPULSE NOISE; CASPASE;
NECROSIS; INJURY
AB We have reported that by 2 days after noise exposure the size of cochlear lesion was expanding by outer hair cells (OHCs) dying either by apoptosis or necrosis [Hear. Res. 166 (2002) 62]. The current study was designed to compare the prevalence of the two cell death pathways as a function of time after exposure to noises of different levels. Chinchillas were exposed to a narrow band noise at either 104 or 108 dB SPL for I h. At three time points (1, 4 and 30 days) after the noise exposure, the numbers of missing, apoptotic and necrotic CHCs in the cochleas were identified and documented with a combination of TUNEL, caspase-3 and propidium iodide labeling. The subjects exposed to the 108-dB noise showed significantly more apoptotic OHCs than necrotic OHCs in the cochleas examined at days 1 and 4 after the noise exposure. By day 30, apoptotic and necrotic pathologies continued, although in small quantity, with no significant difference in quantity between two types of cell death. The subjects exposed to the 104-dB noise showed a significant difference in the numbers of apoptotic and necrotic OHCs at day I after the noise exposure, whereas the difference became statistically insignificant at day 4 and day 30 after the noise exposure. The results of the study indicate that the early expansion of cochlear lesion is attributed primarily to apoptosis, whereas the later stage of lesion expansion is likely the result of an equal contribution from apoptosis and necrosis. (C) 2004 Elsevier B.V. All rights reserved.
C1 SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
Roswell Pk Canc Inst, Dept Mol & Cellular Biophys, Buffalo, NY 14263 USA.
RP Hu, BH (reprint author), SUNY Buffalo, Ctr Hearing & Deafness, 137 Cary Hall,3435 Main St, Buffalo, NY 14214 USA.
EM bhu@acsu.buffalo.edu
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NR 19
TC 54
Z9 65
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 69
EP 76
DI 10.1016/j.heares.2004.04.015
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700010
PM 15464303
ER
PT J
AU Okamoto, H
Ross, B
Kakigi, R
Kubo, T
Pantev, C
AF Okamoto, H
Ross, B
Kakigi, R
Kubo, T
Pantev, C
TI N1m recovery from decline after exposure to noise with strong spectral
contrasts
SO HEARING RESEARCH
LA English
DT Article
DE auditory evoked response; habituation; stimulus specific adaptation;
lateral inhibition; auditory cortex; MEG
ID HUMAN AUDITORY-CORTEX; TEMPORAL INTEGRATION; HABITUATION; RESPONSES;
FREQUENCY; ACTIVATION; INTENSITY; HEARING; STIMULI; FIELDS
AB Comb-filtered noise (CFN, derived from white noise by suppressing regularly spaced frequency regions) was presented for 3 s followed by two types of test stimuli. One test stimulus (SB) was comprised of spectra centered in the stop-band regions of the CFN and the other test stimulus (PB) of spectra centered in the band pass regions of the CFN. Magnetoencephalographically recorded N1m responses evoked by SB stimuli were decreased relative to the N1m response evoked by PB stimuli. This effect was maximal when the interval between the CFN and test stimuli was short (0.5 s) but was detected at intervals up to 2 s. The results suggest lateral inhibition in the auditory cortex and point to a decay of inhibition lasting on the order of seconds. (C) 2004 Elsevier B.V. All rights reserved.
C1 Baycrest Ctr Geriatr Care, Rotman Res Inst Neurosci, Toronto, ON, Canada.
Natl Inst Physiol Sci, Dept Biol Control Syst, Div Sensori Motor Integrat, Okazaki, Aichi, Japan.
Osaka Univ, Sch Med, Dept Otorhinolaryngol & Sensory Organ Surg, Osaka, Japan.
Univ Munster Hosp, Inst Biomagnet & Biosignalanal, D-48129 Munster, Germany.
RP Pantev, C (reprint author), Baycrest Ctr Geriatr Care, Rotman Res Inst Neurosci, Toronto, ON, Canada.
EM pantev@uni-muenster.de
RI Okamoto, Hidehiko/A-7934-2008
OI Okamoto, Hidehiko/0000-0003-2799-3340
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NR 27
TC 21
Z9 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 77
EP 86
DI 10.1016/j.heares.2004.04.017
PG 10
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700011
PM 15464304
ER
PT J
AU Piatto, VB
Bertollo, EMG
Sartorato, EL
Maniglia, JV
AF Piatto, VB
Bertollo, EMG
Sartorato, EL
Maniglia, JV
TI Prevalence of the GJB2 mutations and the del(GJB6-D13S1830) mutation in
Brazilian patients with deafness
SO HEARING RESEARCH
LA English
DT Article
DE hearing loss; molecular analysis; connexin 26; 35delG mutation;
del(GJB6-D13S1830) mutation
ID CONNEXIN 26 GENE; AUTOSOMAL-RECESSIVE DEAFNESS; NONSYNDROMIC
HEARING-LOSS; SENSORINEURAL DEAFNESS; PRELINGUAL DEAFNESS; GREEK
POPULATION; 35DELG MUTATION; UNITED-STATES; FREQUENCY; DFNB1
AB Mutations in the GJB2 gene are the most common cause of sensorineural non-syndromic deafness in different populations. One specific mutation, 35delG, has accounted for the majority of the mutations detected in the GJB2 gene in many countries. The aim of this study was to determine the prevalence of GJB2 mutations and the del(GJB6-D13S1830) mutation in non-syndromic deaf Brazilians. The 33 unrelated probands were examined by clinical evaluation to exclude syndromic forms of deafness. Mutation analysis in the GJB2 gene and the testing for the del(GJB6-Dl3S1830) were performed in both the patients and their family members. The 35delG mutation was found in nine of the probands or in 14 of the mutated alleles. The V371 mutation and the del(GJB6-D13S1830) mutation were also found in two patients, both are compound heterozygote with 35delG mutation. These findings strengthen the importance of genetic diagnosis, providing early treatment, and genetic counseling of deaf patients. (C) 2004 Elsevier B.V. All rights reserved.
C1 FAMERP, BR-15025390 Sao Paulo, Brazil.
UNICAMP, CBMEG, BR-13083970 Sao Paulo, Brazil.
RP Piatto, VB (reprint author), FAMERP, Rua Frei Baltazar,415 Boa Vista, BR-15025390 Sao Paulo, Brazil.
EM vabp@bol.com.br; eny.goloni@famerp.br; sartor@unicamp.br;
diretoriageral@famerp.br
RI Piatto, Vania/F-8745-2011; Goloni-Bertollo, Eny/B-8405-2012
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NR 46
TC 14
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 87
EP 93
DI 10.1016/j.heares.2004.05.007
PG 7
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700012
ER
PT J
AU Harding, GW
Bohne, BA
AF Harding, GW
Bohne, BA
TI Temporary DPOAE level shifts, ABR threshold shifts and histopathological
damage following below-critical-level noise exposures
SO HEARING RESEARCH
LA English
DT Article
DE DPOAE; ABR; noise; organ of Corti; histopathology; chinchilla
ID PRODUCT OTOACOUSTIC EMISSIONS; SENSORY CELL LOSS; CHINCHILLA-COCHLEA;
DISTORTION PRODUCTS; ACOUSTIC TRAUMA; SOUND; DEPENDENCE; AMPLITUDE;
HEARING; RABBIT
AB DPOAE temporary level shift (TLS) at 2f(1)-f(2) and f(2) -f(1), ABR temporary threshold shift (TTS), and detailed histopathological findings were compared in three groups of chinchillas that were exposed for 24 It to an octave band of noise (OBN) centered at 4 kHz with a sound pressure level (SPL) of 80, 86 or 92 dB (n = 3,4,6). DPOAE levels at 39 frequencies from f(1) = 0.3 to 16 kHz (f(2)/f(1) = 1.23; L-2 and L-1 = 55, 65 and 75 dB, equal and differing by 10 dB) and ABR thresholds at 13 frequencies from 0.5 to 20 kHz were collected pre- and immediately post-exposure. The functional data were converted to pre- minus post-exposure shift and overlaid upon the cytocochleogram of cochlear damage using the frequency-place map for the chinchilla. The magnitude and frequency place of components in the 2f(1) -f(2) TLS patterns were determined and group averages for each OBN SPL and L-1, L-2 combination were calculated. The f(2) -f(1) TLS was also examined in ears with focal lesions equal to or greater than 0.4 mm. The 2f(1) -f(2) TLS (plotted at f(1)) and TTS aligned with the extent and location of damaged supporting cells. The TLS patterns over frequency had two features which were unexpected: (1) a peak at about a half octave above the center of the OBN with a valley just above and below it and (2) a peak (often showing enhancement) at the apical boundary of the supporting-cell damage. The magnitudes of the TLS and TTS generally increased with increasing SPL of the exposure. The peaks of the TLS and TTS, as well as the peaks and valleys of the TLS pattern moved apically as the SPL of the OBN was increased. However, there was little consistency in the pattern relations with differing L1, L-2 combinations. In addition, neither the 2f(1) -f(2) nor f(2)-f(1) TLS for any L-1, L-2 combination reliably detected focal lesions (100% OHC loss) from 0.4 to 1.2 mm in size. Often, the TLS went in the opposite direction from what would be expected at focal lesions. Recovery from TLS and TTS was also examined in seven animals. Both TLS and TTS recovered partially or completely, the magnitude depending upon exposure SPL. (C) 2004 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
RP Harding, GW (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, POB 8115,660 S Euclid, St Louis, MO 63110 USA.
EM hardingg@wustl.edu
RI Bohne, Barbara/A-9113-2008
OI Bohne, Barbara/0000-0003-3874-7620
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NR 36
TC 11
Z9 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 94
EP 108
DI 10.1016/j.heares.2004.03.011
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700013
PM 15464306
ER
PT J
AU Soeta, Y
Hotehama, T
Nakagawa, S
Tonoike, M
Ando, Y
AF Soeta, Y
Hotehama, T
Nakagawa, S
Tonoike, M
Ando, Y
TI Auditory evoked magnetic fields in relation to interaural
cross-correlation of band-pass noise
SO HEARING RESEARCH
LA English
DT Article
DE magnetoencephalography (MEG); auditory evoked response; N1m; interaural
crosscorrelation function
ID MASKING-LEVEL DIFFERENCES; BINAURAL INTERACTION; CORRELATION MODEL;
SOUND FIELDS; SIGNALS; LATERALIZATION; POTENTIALS; FREQUENCY; TONES
AB Auditory evoked magnetic fields of the human brain were analyzed in relation to the magnitude of the inter-aural cross-correlation (IACC). IACC of the stimuli was controlled by mixing diotic bandpass and dichotic, independent bandpass noise in appropriate ratios. The auditory stimuli were binaurally delivered through plastic tubes and earpieces inserted into ear canals of the nine volunteers with normal hearing who took part in this study. All source signals had the same sound pressure level. Auditory evoked fields (AEFs) were recorded using a neuromagnetometer in a magnetically shielded room. Combinations of a reference stimulus (IACC = 1.0) and test stimuli (IACC = 0.2, 0.6, 0.85) were presented alternately at a constant interstimulus interval of 0.5 s and MEGs recorded. The results showed that the N1m latencies were not affected by IACC; however, the peak amplitude of N1m significantly decreased with increasing TACC. (C) 2004 Elsevier B.V. All rights reserved.
C1 AIST, Inst Human Sci & Biomed Engn, Ikeda, Osaka 5638577, Japan.
Kobe Univ, Grad Sch Sci & Technol, Kobe, Hyogo 6578501, Japan.
RP Soeta, Y (reprint author), AIST, Inst Human Sci & Biomed Engn, 1-8-31 Midorigaoka, Ikeda, Osaka 5638577, Japan.
EM y.soeta@aist.go.jp
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NR 28
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 109
EP 114
DI 10.1016/j.heares.2004.07.002
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700014
PM 15464307
ER
PT J
AU Frei, K
Ramsebner, R
Lucas, T
Baumgartner, WD
Schoefer, C
Wachtler, FJ
Kirschhofer, K
AF Frei, K
Ramsebner, R
Lucas, T
Baumgartner, WD
Schoefer, C
Wachtler, FJ
Kirschhofer, K
TI Screening for monogenetic del(GJB6-D13S1830) and digenic
del(GJB6-D13S1830)/GJB2 patterns of inheritance in deaf individuals from
Eastern Austria
SO HEARING RESEARCH
LA English
DT Article
DE sensorineural deafness; del(GJB6-D13S1830); GJB2; GJB6; Connexin 30;
Connexin 26; Austria; mutation
ID CONNEXIN 26 GENE; SYNDROMIC HEARING-LOSS; SENSORINEURAL DEAFNESS;
DOMINANT DEAFNESS; GAP-JUNCTION; MUTATIONS; GJB2; VARIABILITY;
IMPAIRMENT; PREVALENCE
AB Genetically caused congenital deafness is a common trait affecting I in 2000 newborn children and is predominantly inherited in an autosomal recessive fashion. Genes such as the gap junction protein beta 2 (GJB2) encoding for Connexin (Cx26) and GJB6 (Cx30) are known to cause sensorineural deafness. Autosomal recessive deafness has been linked both to the monogenetic occurrence of mutated GJB2 or the GJB6 deletion del(GJB6-D13S1830) and digenic GJB2/del(GJB6-D13S1830) inheritance. Monogenetic GJB2 alterations are responsible for 25.5% of deafness in the eastern Austrian population. An additional 9.8% are heterozygous carriers of a single GJB2 mutation which is not responsible for deafness alone. Del(GJB6-D13S1830) and GJB2/ del(GJB6-D13S1830) mutations have been shown to be the second most frequent cause of deafness in different populations. To address the question of the relevance of mutations in GJB6 either as a monogenetic ora digenic GJB2/del(GJB6-D13S1830) cause of deafness in this population, 76 unrelated individuals (33 families and 43 sporadic cases) were screened using PCR strategies. Similar to studies in other hard of hearing populations with similar or lower carrier frequencies of single GJB2 mutations, the presence of del(GJB6-D13S1830) was not detected in any individual within the patient group. Data therefore exclude a digenetic association of del(GJB6-D13S1830) with heterozygous GJB2 mutations as a cause of deafness in a representative sample of the population from Eastern Austria. (C) 2004 Elsevicr B.V. All rights reserved.
C1 Med Univ Vienna, Dept Otorhinolaryngol, A-1090 Vienna, Austria.
Med Univ Vienna, Dept Histol & Embryol, A-1090 Vienna, Austria.
Med Univ Vienna, Dept Clin Pharmacol, A-1090 Vienna, Austria.
Krankenhaus Barmherzigen Bruder, Dept Otorhinolaryngol, A-1020 Vienna, Austria.
RP Frei, K (reprint author), Med Univ Vienna, Dept Otorhinolaryngol, AKH-8J,Waehringer Gurtel 18-20, A-1090 Vienna, Austria.
EM klemens.frei@akh-wien.ac.at
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NR 23
TC 15
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 115
EP 118
DI 10.1016/j.heares.2004.07.001
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700015
PM 15464308
ER
PT J
AU Valentine, PA
Eggermont, JJ
AF Valentine, PA
Eggermont, JJ
TI Stimulus dependence of spectro-temporal receptive fields in cat primary
auditory cortex
SO HEARING RESEARCH
LA English
DT Article
DE cat; cortex; single unit; multi unit; spectro-temporal receptive field
ID FREQUENCY-MODULATED SOUNDS; NATURAL SOUNDS; COCHLEAR NUCLEUS; CORTICAL
FIELDS; NEURONS; INHIBITION; RESPONSES; ORGANIZATION; GRASSFROG;
REPRESENTATION
AB The frequency-tuning curve is a static representation of the neuron's sensitivity to stimulus frequency. The temporal aspects of the frequency sensitivity can be captured in the spectro-temporal receptive field (STRF), often presented as the average spectrogram of the stimulus preceding a spike but also as the average frequency-dependent post-stimulus time histogram (PSTH). The temporal envelope of the stimulus produces considerable smoothing, and as a consequence the PSTH representation is finer-grained than the spectrogram representation. Here we compare STRFs for 1/s and 20/s single-frequency stimuli with 120/s steady-state multi-frequency stimuli for 87 recording sites in primary auditory cortex of cats. For the 672 estimated STRFs, which for multi-frequency stimuli were mostly obtained at 55 dB SPL, we found lateral inhibition in 17% of the cases, in 32% post-activation suppression, and in 51% only excitation. In 35% of the recordings the excitatory frequency-tuning curves were very similar for single and multi-frequency stimuli, in the remaining 65% the common finding was the emergence of an intensity independent bandwidth for the multi-frequency stimuli. Comparison of the 20/s and 120/s stimuli showed that the resulting increase in inhibition was strongest in the center of he STRF. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Calgary, Dept Physiol & Biophys, Calgary, AB, Canada.
Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
RP Eggermont, JJ (reprint author), Univ Calgary, Dept Physiol & Biophys, Calgary, AB, Canada.
EM eggermon@ucalgary.ca
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NR 41
TC 48
Z9 48
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD OCT
PY 2004
VL 196
IS 1-2
BP 119
EP 133
DI 10.1016/j.heares.2004.05.011
PG 15
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 864BU
UT WOS:000224608700016
PM 15464309
ER
PT J
AU Nagy, I
Bodmer, M
Brors, D
Bodmer, D
AF Nagy, I
Bodmer, M
Brors, D
Bodmer, D
TI Early gene expression in the organ of Corti exposed to gentamicin
SO HEARING RESEARCH
LA English
DT Article
DE DNA microarray; gentamicin; hair cells; organ of corti
ID HAIR-CELLS; INNER-EAR; DAMAGE; GENERATION; PROTECTION; NEURONS; CULTURE
AB Studies have demonstrated different pathogenetic key factors in gentamicin-induced hair cell death. The production of reactive oxygen species (ROS), as well as apoptosis-related genes, play a critical role. However, a coordinated large-scale investigation of gene expression in the organ of Corti (OC) exposed to gentamicin has not yet been conducted. Here we used DNA microarray technology to compare the expression profile of OC exposed to gentamicin to the expression profile of untreated OC.
The OCs of Sprague Dawley rats were dissected and the basal turns were cultured. Two-thirds of the explants were then exposed to 100 muM gentamicin, for 4 and 8 h, while one-third of the explants remained in culture medium alone. Gene expression was analyzed using DNA microarray technology and the dChip software package. Based on the results, the 4-h time-point was chosen for further analysis. In these assays, out of 8800 genes, 12 genes were identified on the basis of differential expression in the OC exposed to gentamicin vs. control OC.
The identity of these genes suggests that the response of the OC to the gentamicin challenge involves down-regulation of specific gene families in order to alleviate ROS and N-methyl-D-aspartate (NMDA) receptor-mediated cellular stress. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Zurich Hosp, Clin Otolaryngol Head & Neck Surg, CH-8091 Zurich, Switzerland.
Swiss Fed Inst Technol, ETHZ, CH-8092 Zurich, Switzerland.
Univ Wurzburg, Dept Otolaryngol Head & Neck Surg, D-97080 Wurzburg, Germany.
RP Bodmer, D (reprint author), Univ Zurich Hosp, Clin Otolaryngol Head & Neck Surg, Frauenklin Str 24, CH-8091 Zurich, Switzerland.
EM daniel.bodmer@orl.usz.ch
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NR 23
TC 12
Z9 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 1
EP 8
DI 10.1016/j.heares.2004.04.010
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100001
PM 15350274
ER
PT J
AU Yoshino, T
Sato, E
Nakashima, T
Nagashima, W
Teranishi, MA
Nakayama, A
Mori, N
Murakami, H
Funahashi, H
Imai, T
AF Yoshino, T
Sato, E
Nakashima, T
Nagashima, W
Teranishi, MA
Nakayama, A
Mori, N
Murakami, H
Funahashi, H
Imai, T
TI The immunohistochemical analysis of pendrin in the mouse inner ear
SO HEARING RESEARCH
LA English
DT Article
DE Pendred's syndrome; pendrin; immunohistochemical analysis; inner ear;
mouse
ID SENSORINEURAL HEARING-LOSS; ION-TRANSPORT; GENE PDS; MUTATIONS;
DEAFNESS; COCHLEA; NEURONS; COTRANSPORTER; MAINTENANCE; CONNEXINS
AB Pendred's syndrome (PS) is an autosomal recessive disorder characterized by deafness and goiter, which are caused by mutations in the Pendred's syndrome gene (PDS). PDS encodes a membrane protein named pendrin that is considered to act as an anion transporter. An expression pattern of the PDS ortholog (Pds) mRNA in the auditory and vestibular systems has been reported in mice. and the localization of pendrin has been reported recently. We generated antipeptide antibodies against human pendrin, and performed immunohistochemical analysis of mouse inner cars. We detected pendrin in the endolymphatic duct and sac, and the utricle. saccule, and external sulcus. In the endolymphatic duct and sac, the expression of pendrin was apparent at the apical membrane. In addition, we detected pendrin in the spiral ligament, Claudius cells, Deiter's cells, and the spiral ganglion of the cochlea. Our results are key to defining the role of pendrin in inner ear development and elucidating the pathogenic mechanisms underlying deafness in PS. (C) 2004 Elsevier B.V. All rights reserved.
C1 Nagoya Univ, Dept Otorhinolaryngol, Showa Ku, Nagoya, Aichi 4668550, Japan.
Nagoya Univ, Dept Pathol 1, Showa Ku, Nagoya, Aichi 4668550, Japan.
Nagoya Univ, Dept Pathol 2, Showa Ku, Nagoya, Aichi 4668550, Japan.
Nagoya Univ, Dept Surg 2, Showa Ku, Nagoya, Aichi 4668550, Japan.
RP Yoshino, T (reprint author), Nagoya Univ, Dept Otorhinolaryngol, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
EM yoshinot@med.nagoya-u.ac.jp
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NR 40
TC 15
Z9 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 9
EP 16
DI 10.1016/j.heares.2004.05.005
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100002
PM 15350275
ER
PT J
AU Hayashi, H
Sone, M
Ito, S
Wakamatsu, K
Kato, M
Nakashima, I
Nakashima, T
AF Hayashi, H
Sone, M
Ito, S
Wakamatsu, K
Kato, M
Nakashima, I
Nakashima, T
TI A novel RFP-RET transgenic mouse model with abundant eumelanin in the
cochlea
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; eumelanin; MT/RFP-RET transgenic mouse
ID PIGMENTED GUINEA-PIGS; CHLOROQUINE-TREATED RED; INDUCED HEARING-LOSS;
STRIA VASCULARIS; INNER-EAR; ACOUSTIC TRAUMA; TRANSFORMING GENE; ALBINO;
NOISE; MELANIN
AB We report on the cochlea of a novel metallothionein-I (MT)/RFP-RET transgenic mouse model with severe systemic melanosis. Electron microscopy revealed that these transgenic mice possess abundant quantities of melanin in the intermediate cells of the stria vascularis. High performance liquid chromatography analysis indicated that cochleae of these transgenic mice contained about twice as much eumelanin as cochleae of control C57BL/6 mice and that the amount of pheomelanin was approximately equal in these two strains. Auditory brainstem responses at 2, 4, 8, and 16 kHz were not significantly different between transgenic and control mice. This is the first report on a mouse model of overproduction of cochlear eumelanin, and our results suggest that this transgenic mouse is an excellent model for investigating the effects of overexpression of cochlear eumelanin. In addition, we provide evidence that eumelanin overproduction in the cochlea does not affect normal hearing. (C) 2004 Elsevier B.V. All rights reserved.
C1 Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Showa Ku, Nagoya, Aichi 4668550, Japan.
Fujita Hlth Univ, Sch Hlth Sci, Toyoake, Aichi 4701192, Japan.
Kanazawa Univ, Dept Environm & Prevent Med, Grad Sch Med Sci, Kanazawa, Ishikawa 9208640, Japan.
Nagoya Univ, Grad Sch Med, Dept Immunol, Showa Ku, Nagoya, Aichi 4668550, Japan.
RP Hayashi, H (reprint author), Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
EM hideo@med.nagoya.u.ac.jp
RI Nakashima, Tsutomu/B-8259-2012
OI Nakashima, Tsutomu/0000-0003-3930-9120
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NR 34
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 35
EP 40
DI 10.1016/j.heares.2004.01.020
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100004
PM 15350277
ER
PT J
AU Shatz, LF
AF Shatz, LF
TI The effect of hair bundle shape on hair bundle hydrodynamics of
non-mammalian inner ear hair cells for the full frequency range
SO HEARING RESEARCH
LA English
DT Article
DE cochlea; hair bundle; hydrodynamics; spheroid; hair cell; tectorial
membrane
ID ALLIGATOR LIZARD COCHLEA; BOUNDARY-ELEMENT METHOD;
MECHANOELECTRICAL-TRANSDUCTION; FREESTANDING STEREOCILIA; HEMISPHEROIDAL
PROTUBERANCES; MECHANICAL STIMULATION; SIGNAL TRANSMISSION; SINGULARITY
METHOD; BASILAR PAPILLA; MODEL
AB The effect of the size and the shape of the hair bundle of a hair cell in the inner ear of non-mammals on its motion for the full range of frequencies is determined thereby extending the results of a previous analysis of hair bundle motion for high and low frequencies [Hear Res. 141 (2000) 39-50]. A hemispheroid is used to represent the hair bundle because it can represent a full range of shapes, from thin, pencil-like shapes to wide, flat, disk-like shapes. Boundary element methods are used to approximate the solution for the hydrodynamics. For physiologically relevant parameters, an excellent match is obtained between the model's predictions and measurements of hair bundle motion in the free-standing region of the basilar papilla of the alligator lizard [Aranyosi, Measuring sound-induced motions of the alligator lizard cochlea. Massachusetts Institute of Technology, PhD Thesis, 2002]. Neither in the model's predictions nor in experimental measurements is sharp tuning observed. The model predicted the low frequency region of neural tuning curves for the alligator lizard and bobtail lizard, but could not predict the sharp tuning or the high frequency region. An element that represents an active mechanism is added to the hair bundle model to predict neural tuning curves, which are sharply tuned, and an excellent match is obtained for all the characteristics of neural tuning curves for the alligator lizard, and for the low and high frequency regions for the bobtail lizard. The model does not predict well the sharp tuning of the shorter hair bundles of the bobtail lizard, possibly because it does not represent tectorial sallets. (C) 2004 Elsevier B.V. All rights reserved.
C1 Suffolk Univ, Dept Elect & Comp Engn, Boston, MA 02445 USA.
Boston Univ, Hearing Res Ctr, Boston, MA 02115 USA.
RP Shatz, LF (reprint author), Suffolk Univ, Dept Elect & Comp Engn, 41 Temple St, Boston, MA 02445 USA.
EM shatz@ee.suffolk.edu
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NR 46
TC 4
Z9 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 41
EP 53
DI 10.1016/j.heares.2004.04.002
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100005
PM 15350278
ER
PT J
AU Irons-Brown, SR
Jones, TA
AF Irons-Brown, SR
Jones, TA
TI Effects of selected pharmacological agents on avian auditory and
vestibular compound action potentials
SO HEARING RESEARCH
LA English
DT Article
DE hearing; balance; cochlea; maculae; gravity receptors; vestibular;
post-synaptic receptors; chicken; glutamate; kynurenate; kainate;
L-NAME; CNQX; NBQX; DAA; MK-801; GABA; AMPA
ID GUINEA-PIG COCHLEA; PULSED LINEAR ACCELERATION; GABA-LIKE
IMMUNOREACTIVITY; HAIR CELL TRANSMITTER; WHITE LEGHORN CHICK; KAINIC
ACID; RECEPTOR SUBUNITS; EVOKED-POTENTIALS; NITRIC-OXIDE; SUBSTANCE-P
AB Glutamate is currently the consensus candidate for the hair cell transmitter in the inner ear of vertebrates. However, other candidate transmitter systems have been proposed and there may be differences in this regard for auditory and vestibular neuroepithelia. In the present study, perilymphatic perfusion was used to deliver prescribed concentrations of ten drugs to the interstitial fluids of the inner ear of hatchling chickens (n = 124). Dose-response curves were obtained for four of these pharmacological agents. The work was carried out in part to distinguish further the neuroepithelial chemical receptors mediating auditory and vestibular compound action potentials (CAPs). Kainic acid (KA) eliminated both auditory and vestibular responses. D-alpha-Amino-adipic acid (DAA) and dizocilpine maleate (MK-801), both NMDA-specific antagonists, failed to alter vestibular CAPs at any concentration. MK-801 significantly and selectively reduced auditory CAPs at concentrations equal to or greater than 1 mM. Similarly, kynurenic acid (4-hydroxyquinoline-2-carboxylic acid, 1 mM), a glutamate antagonist, significantly reduced auditory but not vestibular CAPs. A non-NMDA glutamate receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), reduced vestibular CAPs significantly but only at the highest concentration tested (1 mM). In contrast, CNQX reduced auditory responses at concentration as low as 1 muM. The CNQX concentration effective in reducing auditory CAPs by 50% (EC(50)) was approximately 20 muM. Glutamate (1 mM) as well as alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), a glutamate agonist, significantly reduced auditory CAPs (AMPA EC(50) = 100 muM). Bicuculline, a GABA(A) receptor antagonist, and L-NAME, a nitric oxide synthase inhibitor, failed to alter responses from either modality. These findings support the hypothesis that glutamate receptors mediate auditory CAPs in birds. However, the results underscore a remarkable difference in sensitivity of the vestibular neuroepithelium (here gravity receptors) to non-NMDA receptor antagonists. The basis of the vestibular insensitivity to glutamate blockers is unknown but it may reflect differences in receptors themselves, differences in the transmission modes available to vestibular synapses or differences in the access of compounds to vestibular neuroepithelial receptors from the interstitial-perilymphatic fluid spaces. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
Univ Missouri, Dept Otolaryngol Head & Neck Surg, Columbia, MO 65212 USA.
RP Jones, TA (reprint author), E Carolina Univ, Dept Commun Sci & Disorders, Belk Annex,Greenville & Charles Blvds, Greenville, NC 27858 USA.
EM jonesti@mail.ecu.edu
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NR 100
TC 2
Z9 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 54
EP 66
DI 10.1016/j.heares.2004.02.011
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100006
PM 15350279
ER
PT J
AU Martini, M
Rispoli, G
Farinelli, F
Fesce, R
Rossi, ML
AF Martini, M
Rispoli, G
Farinelli, F
Fesce, R
Rossi, ML
TI Intracellular Ca2+ buffers can dramatically affect Ca2+ conductances in
hair cells
SO HEARING RESEARCH
LA English
DT Article
DE semicircular canals; hair cells; frog; Ca2+ current kinetics;
intracellular buffers
ID CALCIUM CURRENTS; SEMICIRCULAR CANALS; CHANNELS; FROG; SUBUNITS
AB The effects of endogenous and exogenous Ca2+ buffers on Ca2+ current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca2+ channel types: transient currents flow through a drug-resistant channel ("R1"), while non-inactivating channels sustain a steady, plateau current comprised of a large L component and a small drug-resistant fraction ("R2"). In the perforated-patch condition a large and stable Ca2+ current was recorded, with all three components. In whole-cell, a buffer-free pipette solution did not prevent a complete Ca2+ response. The size of the transient and plateau current fractions were greatly reduced, but the ratio between the two fractions, as well as the activation, inactivation and deactivation kinetics, were substantially unmodified. Current amplitude partially recovered with 5 mM EGTA in the pipette solution. With 50 mM EGTA all the kinetic parameters were slowed down and the transient component, but not the plateau component, markedly increased in size. Response kinetics slowed down even more with 30 mM Cs-BAPTA and the Ca-2divided by. waveform was substantially modified. The transient component was very large and inactivated slowly; the remaining very small plateau fraction deactivated along a slow, single exponential time. Under this condition nifedipine (10 muM) produced a great reduction of the transient current, leaving plateau and deactivation phase unaltered. This suggests that only R2 channels were still active at the end of the test and that the minor remaining transient component flowed through slowly but completely inactivating R1 channels. These results confirm the presence of several channel types in semicircular canal receptors, at difference with cochlear hair cells. and highlight a dramatic alteration of L-type channel behavior when intracellular Ca2+ buffers are sufficiently concentrated and fast to interfere with rapid and local changes in Ca2+ levels. (C) 2004 Elsevier B.V. All rights reserved.
C1 Ctr Neurosci, Sez Fisiol & Biofis, Dipartimento Biol, I-44100 Ferrara, Italy.
Univ Insubria, Ctr Neurosci, I-21100 Varese, Italy.
RP Rossi, ML (reprint author), Ctr Neurosci, Sez Fisiol & Biofis, Dipartimento Biol, Via Luigi Borsari 46, I-44100 Ferrara, Italy.
EM rsm@dns.unife.it
RI fesce, riccardo/A-6317-2008; Rossi, Maria Lisa/D-4251-2011
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NR 22
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 67
EP 74
DI 10.1016/j.heares.2004.05.009
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100007
PM 15350280
ER
PT J
AU Hamada, T
Iwaki, S
Kawano, T
AF Hamada, T
Iwaki, S
Kawano, T
TI Speech offsets activate the right parietal cortex
SO HEARING RESEARCH
LA English
DT Article
DE speech offsets; human; parietal cortex; dipole; magnetoencephalography
ID AUDITORY-CORTEX; DISCRIMINATION; RESPONSES; ATTENTION; SYSTEMS; STIMULI
AB Speech offsets, i.e., sudden transitions from continuous speech sound to silence, activated both hemispheres differently. In addition to peak activities in the bilateral temporal cortices at about 120 ms after the offsets, the right parietal cortex was activated later irrespective of the stimulated ear. The result was discussed in the context of auditory attention. (C) 2004 Elsevier B.V. All rights reserved.
C1 Natl Inst Adv Ind Sci & Technol, AIST, Kansai Ctr, Ikeda, Osaka 5638577, Japan.
Setsunan Univ, Neyagawa, Osaka 5728508, Japan.
RP Hamada, T (reprint author), Natl Inst Adv Ind Sci & Technol, AIST, Kansai Ctr, 1-8-31 Midoriga Oka, Ikeda, Osaka 5638577, Japan.
EM hamada-takashi@aist.go.jp
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NR 12
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 75
EP 78
DI 10.1016/j.heares.2004.04.013
PG 4
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100008
PM 15350281
ER
PT J
AU Smittkamp, SE
Durham, D
AF Smittkamp, SE
Durham, D
TI Contributions of age, cochlear integrity, and auditory environment to
avian cochlear nucleus metabolism
SO HEARING RESEARCH
LA English
DT Article
DE aging; auditory; chicken; cytochrome oxidase; metabolism; nucleus
magnocellularis
ID NERVE ELECTRICAL-ACTIVITY; CONDUCTIVE HEARING-LOSS; BRAIN-STEM; INFERIOR
COLLICULUS; AFFERENT INFLUENCES; CYTOCHROME-OXIDASE; CELL-SIZE;
ANTIOXIDANT ENZYMES; NEURONAL-ACTIVITY; PROTEIN-SYNTHESIS
AB Most commercially raised broiler chickens display progressive cochlear degeneration with age [Hear. Res. 166 (2002) 82]. Recent work examining the effects of age and cochlear degeneration on avian cochlear nucleus (nucleus magnocellularis, NM) metabolism showed that changes in metabolic activity occur with age and cochlear damage [Hear. Res. 175 (2003) 101]. The auditory environment also differed between facilities housing young and adult birds. The relative contributions of age, cochlear degeneration, and auditory environment to these changes in NM metabolism are unknown.
Using cytochrome oxidase (CO) histochemistry, NM neuron metabolism is examined in several age groups of birds under varying conditions. When normal cochlear integrity and auditory environment are held constant, CO staining is significantly decreased in adult vs. young birds. When age and auditory environment are held constant, CO staining is significantly decreased in birds with damaged vs. normal cochleae. When age and normal cochlear integrity are held constant, CO staining is significantly decreased in birds living in a quiet vs. noisy environment. All factors examined cause changes in CO staining, which is indicative of NM metabolic activity. Results are discussed in the context of mitochondrial aging, afferent regulation, and auditory deprivation and enrichment. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Kansas, Smith Mental Retardat Res Ctr, Dept Otolaryngol Head & Neck Surg, Ctr Med, Kansas City, KS 66160 USA.
Univ Kansas, Med Ctr, Dept Speech & Hearing, Kansas City, KS 66160 USA.
RP Durham, D (reprint author), Univ Kansas, Smith Mental Retardat Res Ctr, Dept Otolaryngol Head & Neck Surg, Ctr Med, 3901 Rainbow Blvd, Kansas City, KS 66160 USA.
EM ddurham@kumc.edu
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NR 45
TC 6
Z9 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 79
EP 89
DI 10.1016/j.heares.2004.05.008
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100009
PM 15350282
ER
PT J
AU McCullough, BJ
Tempel, BL
AF McCullough, BJ
Tempel, BL
TI Haplo-insufficiency revealed in deafwaddler mice when tested for hearing
loss and ataxia
SO HEARING RESEARCH
LA English
DT Article
DE deafwaddler; Atp2b2; PMCA2; hearing loss; deafness; mouse
ID HAIR-CELL STEREOCILIA; WRIGGLE-MOUSE-SAGAMI; SYNDROME TYPE 1D; INBRED
STRAINS; PMCA2 MUTATION; RAT-BRAIN; CADHERIN; CA2+; AGE; DEAFNESS
AB The auditory and vestibular systems rely on the plasma membrane calcium ATPase, isoform 2 (PMCA2) to extrude calcium that enters the stereocilia, during transduction. Mutations in the gene encoding this protein result in recessive sensorineural deafness and ataxia in the deafwaddler mouse. In this study, we report the identification of a new allele of deafwaddler, dfw(3J). This allele contains a 4-nucleotide deletion resulting in a frame-shift and predicted truncation of PMCA2. No protein is detected in dfw(3J) homozygotes. To examine the dependence of auditory and vestibular function on PMCA2 activity, we compared dfw(3J) with another functional null allele, dfw(2J), and the partial loss-of-function allele, dfw. All mice studied were in the good-hearing CBA/CaJ background. Heterozygotes of either functional null allele displayed highly significant hearing loss by auditory-evoked brainstem responses relative to controls (P < 0.0001), particularly at high frequencies (>24 kHz). Ataxia was also apparent in these mice on an accelerating rotarod (P < 0.05). In contrast, +/dfw mice were not measurably different from controls in either behavioral test. dfw/dfw were deaf, but showed less ataxia than dfw(2J)/dfw(2J) or dfw(3J/)dfw(3J) mice. These results demonstrate that hearing loss and ataxia are dependent on gene dosage and PMCA2 dysfunction. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Washington, Sch Med, Virginia Merrill Bloedel Hearing Res Ctr, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
Univ Washington, Sch Med, Grad Program Neurobiol & Behav, Seattle, WA 98195 USA.
RP Tempel, BL (reprint author), Univ Washington, Sch Med, Virginia Merrill Bloedel Hearing Res Ctr, Dept Otolaryngol Head & Neck Surg, Box 357923, Seattle, WA 98195 USA.
EM bltempel@u.washington.edu
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NR 40
TC 26
Z9 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 90
EP 102
DI 10.1016/j.heares.2004.05.003
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100010
PM 15350283
ER
PT J
AU Ravicz, ME
Rosowski, JJ
Merchant, SN
AF Ravicz, ME
Rosowski, JJ
Merchant, SN
TI Mechanisms of hearing loss resulting from middle-ear fluid
SO HEARING RESEARCH
LA English
DT Article
DE middle car; umbo velocity; otitis media; effusion; viscosity; conductive
hearing loss
ID HUMAN TEMPORAL BONES; ACOUSTIC INPUT IMPEDANCE; DOPPLER VIBROMETER LDV;
HUMAN-CADAVER EARS; SOUND-PRESSURE; OTITIS-MEDIA; EFFUSIONS; CHILDREN;
STAPES; TYMPANOMETRY
AB Fluid in the middle ear, a defining feature of otitis media with effusion (OME), is commonly associated with a 20- to 30-dB conductive hearing loss. The effects and relative importance of various mechanisms leading to conductive hearing loss were investigated in a human temporal bone preparation. Umbo velocity in response to ear-canal sound was measured with a laser vibrometer while saline and silicone fluids of viscosity 5-12,000 cSt were introduced into the middle ear to contact part or all of the tympanic membrane (TM) and fill part or all of the middle ear. At low frequencies, reductions in umbo velocity (DeltaV(U)) of up to 25 dB depended on the percentage of the original middle-ear air space that remained air-filled, which suggests that the primary mechanism in hearing loss at low frequencies is a reduction of the admittance of the middle-ear air space due to displacement of air with fluid. At higher frequencies, DeltaV(U) (of up to 35 dB) depended on the percentage of the TM contacted by fluid, which suggests that the primary mechanism at high frequencies is an increase in tympanic membrane mass by entrained fluid. The viscosity of the fluid had no significant effect on umbo velocity. DeltaV(U) for the fluid-filled middle ear matched hearing losses reported in patients whose middle ear was believed to be completely filled with fluid. The difference between DeltaV(U) for a partly-filled middle ear and hearing losses reported in patients whose middle ear was believed to be incompletely fluid-filled is consistent with the reported effect of middle-ear underpressure (commonly seen in OME) on umbo velocity. Small amounts of air in the middle ear are sufficient to facilitate umbo motion at low frequencies. (C) 2004 Elsevier B.V. All rights reserved.
C1 Massachusetts Eye & Ear Infirm, Eaton Peabody Lab Auditory Physiol, Boston, MA 02114 USA.
MIT, Elect Res Lab, Cambridge, MA 02139 USA.
Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
RP Ravicz, ME (reprint author), Massachusetts Eye & Ear Infirm, Eaton Peabody Lab Auditory Physiol, 243 Charles St, Boston, MA 02114 USA.
EM mer@epl.meei.harvard.edu
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NR 48
TC 35
Z9 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD SEP
PY 2004
VL 195
IS 1-2
BP 103
EP 130
DI 10.1016/j.heares.2004.05.010
PG 28
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 856JI
UT WOS:000224041100011
PM 15350284
ER
PT J
AU Runge-Samuelson, CL
Abbas, PJ
Rubinstein, JT
Miller, CA
Robinson, BK
AF Runge-Samuelson, CL
Abbas, PJ
Rubinstein, JT
Miller, CA
Robinson, BK
TI Response of the auditory nerve to sinusoidal electrical stimulation:
effects of high-rate pulse trains
SO HEARING RESEARCH
LA English
DT Article
DE auditory prosthesis; cochlear implant; electric stimulation; sinusoidal;
pulse trains; evoked potential; auditory nerve; guinea pig; cat
ID COCHLEAR IMPLANTS; NEURONAL RESPONSE; ACTION-POTENTIALS;
ETHACRYNIC-ACID; NOISE; FIBER; CAT; ENHANCEMENT; RECORDINGS; KANAMYCIN
AB Electrical stimulation of the auditory nerve produces highly synchronized responses. As a consequence, electrical stimulation may result in a narrow dynamic range of hearing and poor temporal representation of an input signal. The electrically evoked compound action potential (ECAP) is an electrophysiologic response used for neural assessment in individuals with auditory prostheses. Because the ECAP arises from the activity of a population of auditory nerve fibers, within- and across-fiber synchrony should be evident in the responses. Due to its clinical relevance and reflection of neural response properties, the ECAP is used in the present study to examine changes in neural synchrony. Empirical and modeled single-fiber data indicate that stimulation with electrical pulses of a sufficiently high rate may induce stochastic neural response behaviors. This study investigated the effects of adding high-rate conditioning pulses (5000 pps) on the ECAP in response to 100 Hz electrical sinusoids. The results showed that high-rate conditioning pulses increased response amplitudes at low sinusoidal levels and decreased the amplitudes at high sinusoidal levels, indicating a decrease in the slope of the ECAP growth functions to sinusoidal stimuli. The results are consistent with a hypothesis that high-rate conditioning pulses increase single-fiber relative spread (RS) in response to sinusoidal stimuli, and the effect is highly dependent on the level of the high-rate conditioning pulses. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA.
Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
Univ Iowa, Dept Physiol & Biophys, Iowa City, IA 52242 USA.
RP Runge-Samuelson, CL (reprint author), Med Coll Wisconsin, Dept Otolaryngol & Commun Sci, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
EM crunge@mcw.edu
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NR 31
TC 8
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2004
VL 194
IS 1-2
BP 1
EP 13
DI 10.1016/j.heares.2004.03.020
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 846HL
UT WOS:000223306400001
PM 15276671
ER
PT J
AU Hafidi, A
Decourt, B
MacLennan, AJ
AF Hafidi, A
Decourt, B
MacLennan, AJ
TI CNTFR alpha and CNTF expressions in the auditory brainstem: light and
electron microscopy study
SO HEARING RESEARCH
LA English
DT Article
DE CNTFR alpha; CNTF; development; cochlear nucleus; superior olivary
complex; inferior colliculus; spiral ganglion
ID CILIARY NEUROTROPHIC FACTOR; FACTOR MESSENGER-RNA; ADULT-RAT BRAIN;
LATERAL SUPERIOR OLIVE; CENTRAL-NERVOUS-SYSTEM; RECEPTOR-ALPHA; REGIONAL
DISTRIBUTION; COCHLEAR NUCLEUS; CELL-LINES; IN-VITRO
AB CNTF receptor alpha (CNTFRalpha) is involved in the development, the maintenance and the regeneration of a variety of brain structures. However, its in vivo distribution has not been determined in the auditory system. CNTFRalpha expression was studied in developing and adult rat brainstem auditory nuclei using immunohistochemistry. At birth, the CNTFRalpha immunolabeling was clearly present in somata of the external nucleus of the inferior colliculus but was diffuse throughout brainstem auditory nuclei. The labeling was present in most brainstem auditory nuclei by post-natal day (PND) 6. The intensity of the staining subsequently increased to its highest level at PND21 and decreased to an adult-like appearance by the fourth post-natal week. In adult, CNTFRalpha labeling occurred in most neurons of the cochlear nucleus (CN), the lateral superior olive (LSO), the medial superior olive (MSO), and the medial nucleus of the trapezoid body (MNTB). CNTFRalpha labeling first appeared in the central nucleus of the inferior colliculus (IC) by the end of the fourth week. There was a general increase in the expression of CNTFRalpha that begins prior to the onset of hearing and reaches its highest level after this important developmental stage. Ultrastructural analysis in the adult ventral CN revealed the presence of CNTFR in post-synaptic sites.
The presence of CNTF has been investigated in the adult using both Western blot and immunohistochemistry. Western blot showed the presence of CNTF in both peripheral and central auditory structures. The CNTF label was generally localized to the somatic compartment, in axons and as puncta surrounding neuronal cell bodies and dendrites. Differential CNTF labeling was observed between the different auditory nuclei. CNTF staining is present in neurons of the CN, the MNTB and the LSO, while it is restricted to axons and puncta surrounding neuronal somata in the IC.
The clear presence of CNTFRalpha at post-synaptic terminals and that of its ligand the CNTF in axons and puncta surrounding neuronal cell bodies suggest an anterograde mode of action for CNTF in the central auditory system. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Bordeaux 2, Lab Biol Mol & Cellulaire Audit, Hop Pellegrin, F-33076 Bordeaux, France.
Univ Florida, Coll Med, Dept Neurosci, Inst Brain, Gainesville, FL 32610 USA.
RP Hafidi, A (reprint author), Univ Bordeaux 2, Lab Biol Mol & Cellulaire Audit, Hop Pellegrin, EA3665, F-33076 Bordeaux, France.
EM aziz.hafidi@univ-bpclermont.fr
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NR 61
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2004
VL 194
IS 1-2
BP 14
EP 24
DI 10.1016/j.heares.2004.04.004
PG 11
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 846HL
UT WOS:000223306400002
PM 15276672
ER
PT J
AU Pedemonte, M
Drexler, DG
Velluti, RA
AF Pedemonte, M
Drexler, DG
Velluti, RA
TI Cochlear microphonic changes after noise exposure and gentamicin
administration during sleep and waking
SO HEARING RESEARCH
LA English
DT Article
DE cochlear microphonic; sleep wakefulness; gentamicin white noise
exposure; efferent system; olivo-cochlear bundle
ID AUDITORY EVOKED-POTENTIALS; VISUAL-ATTENTION; NEURAL CONTROL;
GUINEA-PIGS; HAIR-CELLS; NERVE; SUPPRESSION; STIMULATION; MODULATION;
PHYSIOLOGY
AB These experiments were designed to investigate the effect of noise, sleep, and gentamicin on the cochlear microphonic (CM) of the guinea pigs. Are the changes observed due to intrinsic cochlear phenomena or to efferent system actions? To answer this question, noise exposure together with efferent system blockade by gentamicin administration was performed. In the normal (non-treated) animal, noise exposure decreased both variability and amplitude of the tone evoked CM in about the first 10 min while the physiological modulation of slow wave sleep increasing the CM is not present. Following administration of gentamicin, noise no longer affect the CM in about the first 10 min, although it produces amplitude and variability increments. The influence of slow wave sleep on the CM is not altered. Thus, gentamicin does not block the CM sleep/wakefulness related shifts. The data were discussed in terms of the influence of gentamicin on the olivo-cochlear bundle. It was hypothesized that the effects of noise on the CM is a result of both peripheral and central influences. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Repbul, Fac Med, Dept Fisiol, Montevideo 11800, Uruguay.
RP Velluti, RA (reprint author), Univ Repbul, Fac Med, Dept Fisiol, Av Gral Flores 2125, Montevideo 11800, Uruguay.
EM rvelluti@fmed.edu.uy
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NR 33
TC 3
Z9 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2004
VL 194
IS 1-2
BP 25
EP 30
DI 10.1016/j.heares.2004.03.008
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 846HL
UT WOS:000223306400003
PM 15276673
ER
PT J
AU Schwartz, DA
Purves, D
AF Schwartz, DA
Purves, D
TI Pitch is determined by naturally occurring periodic sounds
SO HEARING RESEARCH
LA English
DT Article
DE pitch; auditory; perception; probability; speech; psychoacoustics
ID HUMAN AUDITORY-CORTEX; COMPLEX TONES; VIRTUAL-PITCH; PERCEPTION;
IDENTIFICATION; HARMONICS; REPRESENTATION; DISCRIMINATION; AMBIGUITY;
DOMINANCE
AB The phenomenology of pitch has been difficult to rationalize and remains the subject of much debate. Here we test the hypothesis that audition generates pitch percepts by relating inherently ambiguous sound stimuli to their probable sources in the human auditory environment. A database of speech sounds, the principal source of periodic sound energy for human listeners, was compiled and the dominant periodicity of each speech sound determined. A set of synthetic test stimuli were used to assess whether the major pitch phenomena described in the literature could be explained by the probabilistic relationship between the stimuli and their probable sources (i.e., speech sounds). The phenomena tested included the perception of the missing fundamental, the pitchshift of the residue, spectral dominance and the perception of pitch strength. In each case, the conditional probability distribution of speech sound periodicities accurately predicted the pitches normally heard in response to the test stimuli. We conclude from these findings that pitch entails an auditory process that relates inevitably ambiguous sound stimuli to their probable natural sources. (C) 2004 Elsevier B.V. All rights reserved.
C1 Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA.
Duke Univ, Dept Neurobiol, Durham, NC 27708 USA.
RP Schwartz, DA (reprint author), Duke Univ, Ctr Cognit Neurosci, Box 90999, Durham, NC 27708 USA.
EM schwartz@neuro.duke.edu
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NR 59
TC 13
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2004
VL 194
IS 1-2
BP 31
EP 46
DI 10.1016/j.heares.2004.01.019
PG 16
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 846HL
UT WOS:000223306400004
PM 15276674
ER
PT J
AU Gleich, O
Weiss, M
Strutz, E
AF Gleich, O
Weiss, M
Strutz, E
TI Age-dependent changes in the lateral superior olive of the gerbil
(Meriones unguiculatus)
SO HEARING RESEARCH
LA English
DT Article
DE binaural hearing; aging; GABA; glycine; olivary complex; sound
localization
ID AUDITORY BRAIN-STEM; COCHLEAR-NUCLEUS; GLYCINE IMMUNOREACTIVITY;
INFERIOR COLLICULUS; TRAPEZOID BODY; MEDIAL NUCLEUS; GABA
IMMUNOREACTIVITY; MONGOLIAN GERBIL; FISCHER-344 RAT; RHESUS-MONKEY
AB Data from humans and animal models provide evidence for an age-dependent impairment in the ability to localize sound. The lateral superior olive (LSO) in the ascending auditory pathway is one important center involved in processing of binaural auditory stimuli. To identify potential age-dependent changes we characterized the LSO in young (< 15 months) and old ( greater than or equal to 3 years) gerbils with a special emphasis on the expression of GABA- and glycine-like immuno-reactivity. The dimensions of the LSO, as well as the number and density of glycine- and GABA-immuno-reactive neurons, were not significantly different between young and old gerbils. The size of glycine- and GABA-immuno-reactive neurons was significantly reduced in the high-frequency (medial) limb of the LSO. Over all, age-dependent changes in the LSO of the gerbil were small. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Regensburg, ENT Dept, D-93042 Regensburg, Germany.
RP Gleich, O (reprint author), Univ Regensburg, ENT Dept, Franz Josef Strauss Allee 11, D-93042 Regensburg, Germany.
EM otto.gleich@klinik.uni-regensburg.de
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NR 47
TC 6
Z9 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2004
VL 194
IS 1-2
BP 47
EP 59
DI 10.1016/j.heares.2004.03.016
PG 13
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 846HL
UT WOS:000223306400005
PM 15276675
ER
PT J
AU Karlidag, T
Kaygusuz, I
Keles, E
Yalcin, S
Serhatlioglu, SS
Acik, Y
Ozturk, L
AF Karlidag, T
Kaygusuz, I
Keles, E
Yalcin, S
Serhatlioglu, SS
Acik, Y
Ozturk, L
TI Hearing in workers exposed to low-dose radiation for a long period
SO HEARING RESEARCH
LA English
DT Article
DE high-frequency audiometry; hearing loss; radiation
ID X-RAY-IRRADIATION; EARLY DEGENERATIVE CHANGES; NASOPHARYNGEAL CARCINOMA;
GUINEA PIG; INNER EAR; RADIOTHERAPY; POSTIRRADIATION; THERAPY
AB The aim of the present study was to evaluate changes in hearing thresholds with standard and high frequency audiometry in workers exposed to low-dose ionizing radiation for a long period. A total of 57 (49 male and 8 female) technical staff working in radiology-related jobs who were exposed to occupational radiation were included in the study. The control group consisted of 32 (27 male and 5 female) volunteer subjects with normal hearing. The symptoms like tinnitus, vertigo, weakness and lack of appetite were evaluated. A standard ascending/descending method was applied to the subjects of the study and the control groups in order to determine their hearing thresholds at eleven different frequencies between 250 and 16 000 Hz. In the study group, the working duration of subjects ranged from 4 to 23 years, and the percentage of tinnitus, weakness, vertigo and lack of appetite were 47%, 28%, 24% and 17%, respectively. It was observed that pure tone hearing thresholds were markedly increased for 4000, 6000, 8000, 14 000 and 16 000 Hz frequencies in the study group compared to the control group (p < 0.01). Levels of static compliance and middle ear pressures of the study group were similar to the control group. Tinnitus, vertigo and hearing loss in high frequencies were observed in the subjects exposed to the radiation for a long period. Subjects under high risk should be evaluated periodically. We suggest that the use of standard and high frequency audiometry together could be beneficial in the evaluation of these subjects. (C) 2004 Elsevier B.V. All rights reserved.
C1 Firat Univ, Fac Med, Dept Otorhinolaryngol, TR-23119 Elazig, Turkey.
Firat Univ, Fac Med, Dept Radiodiagnost, TR-23119 Elazig, Turkey.
Firat Univ, Fac Med, Dept Publ Hlth, TR-23119 Elazig, Turkey.
RP Karlidag, T (reprint author), Firat Univ, Fac Med, Dept Otorhinolaryngol, TR-23119 Elazig, Turkey.
EM turgut_karlidag@yahoo.com
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NR 25
TC 0
Z9 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2004
VL 194
IS 1-2
BP 60
EP 64
DI 10.1016/j.heares.2004.04.011
PG 5
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 846HL
UT WOS:000223306400006
PM 15276676
ER
PT J
AU Ignatova, EG
Thalmann, I
Xu, BG
Ornitz, DM
Thalmann, R
AF Ignatova, EG
Thalmann, I
Xu, BG
Ornitz, DM
Thalmann, R
TI Molecular mechanisms underlying ectopic otoconia-like particles in the
endolymphatic sac of embryonic mice
SO HEARING RESEARCH
LA English
DT Article
DE endolympbatic sac; otoconia; otoconin-90
ID GUINEA-PIG; INNER-EAR; MUTATIONS; AGENESIS; PROTEIN; DUCT; FLOW; RAT
AB Otoconin-90, the principal otoconial matrix protein, provided a too] to investigate the molecular mechanism of otoconial morphogenesis. The endolymphatic sac of the embryonic chick and guinea pig contain otoconia. Here, we show that the embryonic mouse transiently expresses ectopic otoconia in the endolymphatic sac. Massive precipitate of otoconin-90-positive material is detectable in the lumen of the endolymphatic sac between embryonic day 14.5 and 17.5 with frequent accretion into more heavily staining otoconia-like particles. Otoconin-90 was also localized at the surface and the interior of epithelial cells lining the endolymphatic sac as well as incorporated into free floating cells. In contrast, in situ hybridization failed to detect mRNA in the endolymphatic duct and sac, even though the adjacent nonsensory vestibular structures are heavily stained. Because of ample expression of otoconin-90 protein in the absence of the corresponding mRNA, we conclude that the luminal otoconin-90 is imported via longitudinal flow from the vestibular compartments, where both mRNA and protein are strongly expressed. Because of absence of mRNA, the expression of the corresponding protein by the epithelia lining the endolymphatic sac can only be explained by a resorptive process, as previously proposed on the basis of the movement of luminal macromolecules. The data do not support the previous hypothesis that the transient expression of otoconia-like particles of the endolymphatic sac represents a vestigial phenomenon from the amphibian stage, since amphibia express ample mRNA encoding otoconin-22 in the endolymphatic sac system. (C) 2004 Elsevier B.V. All rights reserved.
C1 Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA.
Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA.
RP Thalmann, R (reprint author), Washington Univ, Sch Med, Dept Otolaryngol, 660 S Euclid Ave,POB 8115, St Louis, MO 63110 USA.
EM thalmannr@msnotes.wustl.edu
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NR 40
TC 5
Z9 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2004
VL 194
IS 1-2
BP 65
EP 72
DI 10.1016/j.heares.2004.03.019
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 846HL
UT WOS:000223306400007
PM 15276677
ER
PT J
AU Reyes, SA
Salvi, RJ
Burkard, RF
Coad, ML
Wack, DS
Galantowicz, PJ
Lockwood, AH
AF Reyes, SA
Salvi, RJ
Burkard, RF
Coad, ML
Wack, DS
Galantowicz, PJ
Lockwood, AH
TI PET imaging of the 40 Hz auditory steady state response
SO HEARING RESEARCH
LA English
DT Article
DE steady-state auditory evoked potentials; positron emission tomography;
auditory cortex; frontal cortex; thalamus; auditory pathways
ID POSITRON-EMISSION-TOMOGRAPHY; AMPLITUDE-MODULATED TONES; TONOTOPIC
ORGANIZATION; VOLUME MEASUREMENT; CORTEX; BRAIN; ACTIVATION;
OSCILLATIONS; CONNECTIONS; ANATOMY
AB The auditory steady state response (aSSR) is an oscillatory electrical potential recorded from the scalp induced by amplitudemodulated (AM) or click/tone burst stimuli. Its clinical utility has been limited by uncertainty regarding the specific areas of the brain involved in its generation. To identify the generators of the aSSR, O-15-water PET imaging was used to locate the regions of the brain activated by a steady 1 kHz pure tone, the same tone amplitude modulated (AM) at 40 Hz and the specific regions of the brain responsive to the AM component of the stimulus relative to the continuous tone. The continuous tone produced four clusters of activation. The boundaries of these activated clusters extended to include regions in left primary auditory cortex, right non-primary auditory cortex, left thalamus, and left cingulate. The AM tone produced three clusters of activation. The boundaries of these activated clusters extended to include primary auditory cortex bilaterally, left medial geniculate and right middle frontal gyrus. Two regions were specifically responsive to the AM component of the stimulus. These activated clusters extended to include the right anterior cingulate near frontal cortex and right auditory cortex. We conclude that cortical sites, including areas outside primary auditory cortex, are involved in generating the aSSR: There was an unexpected difference between morning and afternoon session scans that may reflect a pre- versus post-prandial state. These results support the hypothesis that a distributed resonating circuit mediates the generation of the aSSR. (C) 2004 Published by Elsevier B.V.
C1 Univ Buffalo, Dept Commun Disorders & Sci, Buffalo, NY 14214 USA.
Univ Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA.
Univ Buffalo, Sch Med & Biomed Sci, Buffalo, NY 14214 USA.
Vet Adm, Western New York Healthcare Syst, Ctr Positron Emiss Tomog, Buffalo, NY 14214 USA.
Univ Buffalo, Dept Otolaryngol, Buffalo, NY 14214 USA.
Univ Buffalo, Dept Neurol, Buffalo, NY 14214 USA.
Univ Buffalo, Ctr Positron Emiss Tomog, Buffalo, NY 14214 USA.
Univ Buffalo, Dept Nucl Med, Buffalo, NY 14214 USA.
RP Lockwood, AH (reprint author), Univ Buffalo, Dept Commun Disorders & Sci, Buffalo, NY 14214 USA.
EM ahl@buffalo.edu
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NR 41
TC 13
Z9 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2004
VL 194
IS 1-2
BP 73
EP 80
DI 10.1016/j.heares.2004.04.001
PG 8
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 846HL
UT WOS:000223306400008
PM 15276678
ER
PT J
AU Frei, K
Ramsebner, R
Hamader, G
Lucas, T
Schoefer, C
Baumgartner, WD
Wachtler, FJ
Kirschhofer, K
AF Frei, K
Ramsebner, R
Hamader, G
Lucas, T
Schoefer, C
Baumgartner, WD
Wachtler, FJ
Kirschhofer, K
TI Lack of association between Connexin 31 (GJB3) alterations and
sensorineural deafness in Austria
SO HEARING RESEARCH
LA English
DT Article
DE sensorineural deafness; Connexin 31; Connexin 26; Austria; mutation
ID AUTOSOMAL-DOMINANT DEAFNESS; HEARING IMPAIRMENT; KCNQ4 GENE; MUTATIONS;
DFNA2; FAMILIES; REGION; FREQUENCY; LOCUS; R32W
AB Mutations in the gap junction protein beta 3 (GJB3) gene encoding Connexin 31 (Cx31) are known to cause autosomal inherited sensorineural deafness, erythrokeratodermia and neuropathy. The role of Cx31 mutations has not been described in familial cases of non-syndromic hearing impairment (NSHI) in central European populations. To identify mutations in the Austrian population, highly selected familial (n = 24) and sporadic (n = 21) cases of isolated NSHI were screened by analysis of the complete coding sequence of Cx31, after exclusion of a common Cx26 causing deafness. Three different variations occurring in a total of 37% of all cases were identified. A C94T (R32W) missense mutation was seen in 4.4% of cases and two silent alterations C357T and C798T were detected in 8.9% and 24.4% of cases exclusively in a heterozygous pattern. No correlation between Cx31 alterations and deafness was found. To investigate the role of heterozygous Cx31 variations for a possibly combination allelic disease inheritance with Cx26 mutations as shown for Connexin 30 and Connexin 26, patients with Cx26 variations were tested. Our data suggest that Cx31 alterations are common but have no or a low genetic relevance in the Austrian hearing impaired population with or without Cx26 alterations. (C) 2004 Elsevier B.V. All rights reserved.
C1 Univ Vienna, Dept Otorhinolaryngol, Univ Hosp Vienna, A-1090 Vienna, Austria.
Univ Vienna, Dept Histol & Embryol, A-1090 Vienna, Austria.
Univ Vienna, Dept Clin Pharmacol, A-1090 Vienna, Austria.
Krankenhaus Barmherzigen Bruder, Dept Otorhinolaryngol, A-1090 Vienna, Austria.
RP Frei, K (reprint author), Univ Vienna, Dept Otorhinolaryngol, Univ Hosp Vienna, AKH-8J Waehringer,Gurtel 18-20, A-1090 Vienna, Austria.
EM klemens.frei@akh-wien.ac.at
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NR 29
TC 7
Z9 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-5955
J9 HEARING RES
JI Hear. Res.
PD AUG
PY 2004
VL 194
IS 1-2
BP 81
EP 86
DI 10.1016/j.heares.2004.03.007
PG 6
WC Audiology & Speech-Language Pathology; Neurosciences;
Otorhinolaryngology
SC Audiology & Speech-Language Pathology; Neurosciences & Neurology;
Otorhinolaryngology
GA 846HL
UT WOS:000223306400009
PM 15276679
ER
EF