FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Weiss, JA Thomson, K Chan, LS AF Weiss, Jonathan A. Thomson, Kendra Chan, Lisa TI A Systematic Literature Review of Emotion Regulation Measurement in Individuals With Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Review DE Autism Spectrum Disorder; emotion regulation; literature review; measurement; psychopathology ID HIGH-FUNCTIONING AUTISM; CHILDRENS BEHAVIOR QUESTIONNAIRE; RANDOMIZED CONTROLLED-TRIAL; UNIFIED TREATMENT APPROACH; TORONTO-ALEXITHYMIA-SCALE; SCHOOL-AGE-CHILDREN; ASPERGER-SYNDROME; YOUNG-CHILDREN; PSYCHOMETRIC PROPERTIES; GERMAN VERSION AB Emotion regulation (ER) difficulties are a potential common factor underlying the presentation of multiple emotional and behavioral problems in individuals with Autism Spectrum Disorder (ASD). To provide an overview of how ER has been studied in individuals with ASD, we conducted a systematic review of the past 20 years of ER research in the ASD population, using established keywords from the most comprehensive ER literature review of the typically developing population to date. Out of an initial sampling of 305 studies, 32 were eligible for review. We examined the types of methods (self-report, informant report, naturalistic observation/ behavior coding, physiological, and open-ended) and the ER constructs based on Gross and Thompson's modal model (situation selection, situation modification, attention deployment, cognitive change, and response modulation). Studies most often assessed ER using one type of method and from a unidimensional perspective. Across the 32 studies, we documented the types of measures used and found that 38% of studies used self-report, 44% included an informant report measure, 31% included at least one naturalistic observation/behavior coding measure, 13% included at least one physiological measure, and 13% included at least one open-ended measure. Only 25% of studies used more than one method of measurement. The findings of the current review provide the field with an in-depth analysis of various ER measures and how each measure taps into an ER framework. Future research can use this model to examine ER in a multicomponent way and through multiple methods. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Weiss, Jonathan A.; Thomson, Kendra; Chan, Lisa] York Univ, Dept Psychol, Toronto, ON M3J 1P3, Canada. RP Weiss, JA (reprint author), York Univ, Dept Psychol, Rm 230,Behav Sci Bldg,4700 Keele St, Toronto, ON M3J 1P3, Canada. EM jonweiss@yorku.ca FU Spectrum of Hope Autism Foundation; Chair in Autism Spectrum Disorders Treatment and Care Research (Canadian Institutes of Health Research) [284208]; NeuroDevNet; Sinneave Family Foundation; CASDA; Autism Speaks Canada; Health Canada FX This research is supported by the Spectrum of Hope Autism Foundation and the Chair in Autism Spectrum Disorders Treatment and Care Research (Canadian Institutes of Health Research #284208 in partnership with NeuroDevNet, Sinneave Family Foundation, CASDA, Autism Speaks Canada and Health Canada). CR Abler B, 2009, DIAGNOSTICA, V55, P144, DOI 10.1026/0012-1924.55.3.144 Adamek L, 2011, FOCUS AUTISM DEV DIS, V26, P173, DOI 10.1177/1088357611405041 Adrian M, 2011, J EXP CHILD PSYCHOL, V110, P171, DOI 10.1016/j.jecp.2011.03.009 Aldao A, 2010, CLIN PSYCHOL REV, V30, P217, DOI 10.1016/j.cpr.2009.11.004 Aldao A, 2010, BEHAV RES THER, V48, P974, DOI 10.1016/j.brat.2010.06.002 American Psychiatric Association, 2013, DIAGN STAT MAN MENT Attwood T, 2004, EXPLORING FEELINGS C Attwood T, 2004, BEHAV CHANGE, V21, P147, DOI 10.1375/bech.21.3.147.55995 Attwood T., 2003, ASPERGER SYNDROME AD, P38 Bach M, 1996, PSYCHOTHER PSYCH MED, V46, P23 BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1 Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3 Barnhill G., 2000, ASSESSMENT EFFECTIVE, V25, P147, DOI DOI 10.1177/073724770002500205 Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7 Beaumont R, 2008, J CHILD PSYCHOL PSYC, V49, P743, DOI 10.1111/j.1469-7610.2008.01920.x Berthoz S, 2005, EUR PSYCHIAT, V20, P291, DOI 10.1016/j.eurpsy.2004.06.013 Bilek EL, 2012, BEHAV THER, V43, P887, DOI 10.1016/j.beth.2012.04.007 Bolte S, 2008, J AUTISM DEV DISORD, V38, P776, DOI 10.1007/s10803-007-0443-8 Braaten EB, 2000, J CONSULT CLIN PSYCH, V68, P313, DOI 10.1037//0022-006X.68.2.313 Butterworth T. W., 2013, J AUTISM DEV DISORD, V44, P1535 Campbell-Sills L., 2007, HDB EMOTION REGULATI, P542 Carlson SM, 2007, COGNITIVE DEV, V22, P489, DOI 10.1016/j.cogdev.2007.08.002 Carthy T, 2010, J PSYCHOPATHOL BEHAV, V32, P23, DOI 10.1007/s10862-009-9167-8 CASSIDY J, 1992, CHILD DEV, V63, P603, DOI 10.1111/j.1467-8624.1992.tb01649.x Channon S, 2001, J AUTISM DEV DISORD, V31, P461, DOI 10.1023/A:1012212824307 Connor-Smith JK, 2000, J CONSULT CLIN PSYCH, V68, P976, DOI 10.1037/0022-006X.68.6.976 Dawson G., 1989, AUTISM NATURE DIAGNO, P49 de Bruin EI, 2014, MINDFULNESS, V5, P422, DOI 10.1007/s12671-013-0196-8 Derryberry D, 2002, J ABNORM PSYCHOL, V111, P225, DOI 10.1037//0021-843X.111.2.225 Ehrenreich-May J., 2013, TRANSDIAGNOSTIC TREA, P267 Ekman P., 1978, FACIAL ACTION CODING Ellis L. K., 2001, 2001 BIENN M SOC RES Embregts P, 2009, J INTELL DISABIL RES, V53, P922, DOI 10.1111/j.1365-2788.2009.01204.x Faupel P., 1998, ANGER MANAGEMENT FISH B, 1985, PSYCHOPHARMACOL BULL, V21, P753 Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079 Garnefski N, 2007, EUR CHILD ADOLES PSY, V16, P1, DOI 10.1007/s00787-006-0562-3 Garon N, 2009, J ABNORM CHILD PSYCH, V37, P59, DOI 10.1007/s10802-008-9258-0 Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006 Glaser SE, 2011, RES AUTISM SPECT DIS, V5, P926, DOI 10.1016/j.rasd.2010.11.001 Goldsmith H. H., 1996, LAB TEMPERAMENT ASSE Goldsmith H. H., 1996, TODDLER BEHAV ASSESS Goldsmith HH, 1999, LAB TEMPERAMENT ASSE Gomez C. R., 2005, FOCUS AUTISM OTHER D, V20, P106, DOI [10.1177/10883576050200020101, DOI 10.1177/10883576050200020101] Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015 Gotham K, 2013, AUTISM RES, V6, P33, DOI 10.1002/aur.1263 Gottman JM, 1996, J FAM PSYCHOL, V10, P243, DOI 10.1037/0893-3200.10.3.243 Green J, 2000, J AUTISM DEV DISORD, V30, P279, DOI 10.1023/A:1005523232106 Gresham F. M., 1990, SOCIAL SKILLS RATING Grolnick WS, 1998, INFANT BEHAV DEV, V21, P437, DOI 10.1016/S0163-6383(98)90018-2 Gross J. J., 2007, HDB EMOTION REGULATI, P3 Gross JJ, 2003, J PERS SOC PSYCHOL, V85, P348, DOI 10.1037/0022-3514.85.2.348 Gulsrud AC, 2010, J AUTISM DEV DISORD, V40, P227, DOI 10.1007/s10803-009-0861-x Guy W., 1976, ECDEU ASSESSMENT MAN Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14 Hilton C, 2007, RES AUTISM SPECT DIS, V1, P164, DOI 10.1016/j.rasd.2006.10.002 Hilton CL, 2010, J AUTISM DEV DISORD, V40, P937, DOI 10.1007/s10803-010-0944-8 Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724 Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x Ialongo NS, 1999, AM J COMMUN PSYCHOL, V27, P599, DOI 10.1023/A:1022137920532 Jahromi LB, 2012, J CHILD PSYCHOL PSYC, V53, P1250, DOI 10.1111/j.1469-7610.2012.02560.x Jahromi LB, 2013, RES AUTISM SPECT DIS, V7, P235, DOI 10.1016/j.rasd.2012.08.012 Jawaid A, 2012, J INTELL DISABIL RES, V56, P335, DOI 10.1111/j.1365-2788.2011.01452.x Johnson DR, 2009, EMOTION, V9, P681, DOI 10.1037/a0017095 Jones CRG, 2011, J CHILD PSYCHOL PSYC, V52, P275, DOI 10.1111/j.1469-7610.2010.02328.x Khor AS, 2014, J AUTISM DEV DISORD, V44, P593, DOI 10.1007/s10803-013-1912-x Konstantareas MM, 2006, J AUTISM DEV DISORD, V36, P143, DOI 10.1007/s10803-005-0051-4 Krohne HW, 1996, DIAGNOSTICA, V42, P139 Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4 Laurent AC, 2004, TOP LANG DISORD, V24, P286 Lawson J, 2004, J AUTISM DEV DISORD, V34, P301, DOI 10.1023/B:JADD.0000029552.42724.1b Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0 Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021 Lonigan C. J., 2001, DEV PSYCHOPATHOL, P60 LoVullo SV, 2009, RES DEV DISABIL, V30, P1288, DOI 10.1016/j.ridd.2009.05.004 Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025 LUTKENHAUS P, 1985, CHILD DEV, V56, P1538, DOI 10.1111/j.1467-8624.1985.tb00218.x Lynn S., 2013, EMOTIONAL BEHAV DIFF, V18, P297 Masi G, 2001, J AM ACAD CHILD PSY, V40, P1206, DOI 10.1097/00004583-200110000-00015 Maslin-Cole C., 1990, ATTACHMENT PRESCHOOL, P245 Mazefsky CA, 2012, CHILD DEV PERSPECT, V6, P92, DOI 10.1111/j.1750-8606.2011.00229.x Mazefsky CA, 2013, J AM ACAD CHILD PSY, V52, P679, DOI 10.1016/j.jaac.2013.05.006 Mazefsky CA, 2014, CHILD ADOL PSYCH CL, V23, P15, DOI 10.1016/j.chc.2013.07.002 Mazefsky CA, 2014, AUTISM RES, V7, P344, DOI 10.1002/aur.1366 Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006 Moher D, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000097 Moses EB, 2006, CURR DIR PSYCHOL SCI, V15, P146, DOI 10.1111/j.0963-7214.2006.00425.x Mukhopadhyay A., 2011, J COMMUNITY PSYCHOL, V7, P130 Muris R., 2003, EUROPEAN CHILD ADOLE, V12, P1 Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6 Nelson W. M., 2000, CHILDRENS INVENTORY Neuhaus E, 2014, J AUTISM DEV DISORD, V44, P730, DOI 10.1007/s10803-013-1923-7 Nordahl CW, 2008, J AUTISM DEV DISORD, V38, P1581, DOI 10.1007/s10803-007-0514-x Nosek BA, 2001, SOC COGNITION, V19, P625, DOI 10.1521/soco.19.6.625.20886 Ozsivadjian A, 2014, J AUTISM DEV DISORD, V44, P969, DOI 10.1007/s10803-013-1937-1 Parashar D. S., 1998, MANUAL OPTIMISTIC PE Pouw LBC, 2013, RES AUTISM SPECT DIS, V7, P549, DOI 10.1016/j.rasd.2013.01.002 Pouw LBC, 2013, RES DEV DISABIL, V34, P1256, DOI 10.1016/j.ridd.2012.12.022 Putallaz M., 1983, CHILD DEV, V54, P324 Putnam SP, 2006, J PERS ASSESS, V87, P102, DOI 10.1207/s15327752jpa8701_09 Raymaekers R, 2007, J CLIN EXP NEUROPSYC, V29, P418, DOI 10.1080/13803390600737990 Rieffe C, 2004, EUR J DEV PSYCHOL, V1, P31, DOI 10.1080/17405620344000013 Rieffe C, 2011, AUTISM, V15, P655, DOI 10.1177/1362361310366571 Rieffe C, 2008, PERS INDIV DIFFER, V45, P756, DOI 10.1016/j.paid.2008.08.001 Rieffe C, 2012, EUR J DEV PSYCHOL, V9, P351, DOI 10.1080/17405629.2012.680302 Rieffe C, 2007, PERS INDIV DIFFER, V43, P95, DOI 10.1016/j.paid.2006.11.015 Rothbart MK, 2003, J PERS, V71, P1113, DOI 10.1111/1467-6494.7106009 Rothbart MK, 2001, CHILD DEV, V72, P1394, DOI 10.1111/1467-8624.00355 Samson AC, 2012, EMOTION, V12, P659, DOI 10.1037/a0027975 Samson AC, 2015, AUTISM RES, V8, P9, DOI 10.1002/aur.1387 Samyn V, 2011, RES DEV DISABIL, V32, P483, DOI 10.1016/j.ridd.2010.12.038 Sauter D., 2006, INVESTIGATION VOCAL Sauter DA, 2010, Q J EXP PSYCHOL, V63, P2251, DOI 10.1080/17470211003721642 Scarpa A, 2011, BEHAV COGN PSYCHOTH, V39, P495, DOI 10.1017/S1352465811000063 Schmidt S, 2010, MOTIV EMOTION, V34, P63, DOI 10.1007/s11031-010-9155-z Sharma H. C., 2007, MANUAL SCALE EMOTION Shields A, 1997, DEV PSYCHOL, V33, P906, DOI 10.1037//0012-1649.33.6.906 Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f SMILEY PA, 1994, CHILD DEV, V65, P1723, DOI 10.1111/j.1467-8624.1994.tb00845.x Sofronoff K., 2003, CHILDRENS INVE UNPUB Sofronoff K., 2014, HDB AUTISM ANXIETY, P171 Sofronoff K, 2007, J AUTISM DEV DISORD, V37, P1203, DOI 10.1007/s10803-006-0262-3 Sofronoff K. V., 2003, GOOD AUTISM PRACTICE, V4, P2 South M, 2012, AUTISM RES, V5, P398, DOI 10.1002/aur.1255 Spek AA, 2013, RES DEV DISABIL, V34, P246, DOI 10.1016/j.ridd.2012.08.009 Spence S. H., 1995, SOCIAL SKILLS TRAINI Stone Arthur S., 1994, Annals of Behavioral Medicine, V16, P199 Tani P, 2004, NEUROPSYCHOBIOLOGY, V49, P64, DOI 10.1159/000076412 Thompson R. A., 1994, CHILD DEV */* MONOGR, V59, P25, DOI 10.1111/j.1540-5834.1994.tb01276.x Thompson RA, 2008, CHILD DEV PERSPECT, V2, P124, DOI 10.1111/j.1750-8606.2008.00054.x Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x Trosper SE, 2009, CLIN CHILD FAM PSYCH, V12, P234, DOI 10.1007/s10567-009-0043-6 Van Eylen L, 2011, RES AUTISM SPECT DIS, V5, P1390, DOI 10.1016/j.rasd.2011.01.025 Vaughan Van Hecke A., 2009, CHILD DEV, V80, P1118, DOI DOI 10.1111/J.1467-8624.2009.01320.X Vorst HCM, 2001, PERS INDIV DIFFER, V30, P413, DOI 10.1016/S0191-8869(00)00033-7 WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063 Weiss J. A., CLIN PSYCHO IN PRESS White SW, 2012, J AUTISM DEV DISORD, V42, P1138, DOI 10.1007/s10803-011-1353-3 Williams D, 2010, AUTISM, V14, P285, DOI 10.1177/1362361309344849 Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x Joshi G, 2013, J AUTISM DEV DISORD, V43, P1314, DOI 10.1007/s10803-012-1679-5 Wright M, 2010, J ABNORM CHILD PSYCH, V38, P405, DOI 10.1007/s10802-009-9375-4 Yager J, 2013, AUTISM RES, V6, P631, DOI 10.1002/aur.1331 Zablotsky B, 2013, J DEV BEHAV PEDIATR, V34, P1, DOI 10.1097/DBP.0b013e31827a7c3a Zafar S., 2008, CLIN NEUROPSYCHIATRY, V5, P9 Zeman J, 1996, CHILD DEV, V67, P957, DOI 10.1111/j.1467-8624.1996.tb01776.x NR 146 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 629 EP 648 DI 10.1002/aur.1426 PG 20 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700001 PM 25346416 ER PT J AU Payakachat, N Tilford, JM Kuhlthau, KA van Exel, NJ Kovacs, E Bellando, J Pyne, JM Brouwer, WBF AF Payakachat, Nalin Tilford, J. Mick Kuhlthau, Karen A. van Exel, N. Job Kovacs, Erica Bellando, Jayne Pyne, Jeffrey M. Brouwer, Werner B. F. TI Predicting Health Utilities for Children With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE mapping; predictive algorithms; equating measure; autism; health utilities; clinical measure; behavioral measure; quality of life measure ID QUALITY-OF-LIFE; GENERIC CORE SCALES; ECONOMIC-EVALUATION; COST-EFFECTIVENESS; INTELLECTUAL DISABILITY; INTERVENTIONS; SCORES; INDEX; EQ-5D; PEDSQL(TM)-4.0 AB Comparative effectiveness of interventions for children with autism spectrum disorders (ASDs) that incorporates costs is lacking due to the scarcity of information on health utility scores or preference-weighted outcomes typically used for calculating quality-adjusted life years (QALYs). This study created algorithms for mapping clinical and behavioral measures for children with ASDs to health utility scores. The algorithms could be useful for estimating the value of different interventions and treatments used in the care of children with ASDs. Participants were recruited from two Autism Treatment Network sites. Health utility data based on the Health Utilities Index Mark 3 (HUI3) for the child were obtained from the primary caregiver (proxy-reported) through a survey (N=224). During the initial clinic visit, proxy-reported measures of the Child Behavior Checklist, Vineland II Adaptive Behavior Scales, and the Pediatric Quality of Life Inventory 4.0 (start measures) were obtained and then merged with the survey data. Nine mapping algorithms were developed using the HUI3 scores as dependent variables in ordinary least squares regressions along with the start measures, the Autism Diagnostic Observation Schedule, to measure severity, child age, and cognitive ability as independent predictors. In-sample cross-validation was conducted to evaluate predictive accuracy. Multiple imputation techniques were used for missing data. The average age for children with ASDs in this study was 8.4 (standard deviation=3.5) years. Almost half of the children (47%) had cognitive impairment (IQ70). Total scores for all of the outcome measures were significantly associated with the HUI3 score. The algorithms can be applied to clinical studies containing start measures of children with ASDs to predict QALYs gained from interventions. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Payakachat, Nalin; Tilford, J. Mick] Univ Arkansas Med Sci, Div Pharmaceut Evaluat & Policy, Little Rock, AR 72223 USA. [Tilford, J. Mick] Univ Arkansas Med Sci, Dept Hlth Policy & Management, Little Rock, AR 72223 USA. [Tilford, J. Mick; Bellando, Jayne] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72223 USA. [Kuhlthau, Karen A.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA. [Kuhlthau, Karen A.] Massachusetts Gen Hosp, Ctr Adolescent Hlth Policy, Boston, MA 02114 USA. [van Exel, N. Job; Brouwer, Werner B. F.] Erasmus Univ, Dept Hlth Policy & Management, Rotterdam, Netherlands. [Kovacs, Erica] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA. [Pyne, Jeffrey M.] Cent Arkansas Vet Healthcare Syst, Ctr Mental Healthcare & Outcomes Res, Little Rock, AR USA. [Pyne, Jeffrey M.] Univ Arkansas Med Sci, Inst Psychiat Res, Little Rock, AR 72223 USA. RP Payakachat, N (reprint author), Univ Arkansas Med Sci, Div Pharmaceut Evaluat & Policy, 4301 W Markham St,522, Little Rock, AR 72223 USA. EM npayakachat@uams.edu FU National Institute of Mental Health [R01MH089466, R03MH102495]; Translational Research Institute through the NIH National Center for Research Resources [UL1TR000039]; National Center for Advancing Translational Sciences; U.S. Department of Health and Human Services [UA3MC11054]; Health Resources and Services Administration; Maternal and Child Health Research Program FX The project was supported by Grant No. R01MH089466 from the National Institute of Mental Health with JMT and KAK serving as principal investigators, and Grant No. R03MH102495 with NP as the principal investigator. JMT also was supported by the Translational Research Institute, Grant No. UL1TR000039 through the NIH National Center for Research Resources and National Center for Advancing Translational Sciences. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health. The authors acknowledge the members of the Autism Treatment Network for use of the data. The data for the study were collected as part of the Autism Treatment Network, a program of Autism Speaks. Further support came from a cooperative agreement (UA3MC11054) from the U.S. Department of Health and Human Services, Health Resources and Services Administration, and Maternal and Child Health Research Program, to the Massachusetts General Hospital. The work described in this article represents the independent efforts of the authors with no restrictions from the funding source or the Autism Treatment Network. None of the authors of this study reported a conflict of interest associated with the preparation of the manuscript. Maria Melguizo, Nupur Chowdhury, Rebecca Rieger, and Latunja Sockwell provided excellent research assistance. CR Achenbach T M, 2000, Pediatr Rev, V21, P265, DOI 10.1542/pir.21-8-265 American Psychiatric Association, 2013, DIAGN STAT MAN MENT Bailey AJ, 2009, AUTISM RES, V2, P245, DOI 10.1002/aur.99 Basu A, 2012, MED DECIS MAKING, V32, P56, DOI 10.1177/0272989X11416988 Bayley N., 2005, BAYLEY SCALES INFANT, Vthird Blumberg SJ, 2013, NATL CTR HLTH STAT, V2013, P65 Brazier J. E., 2007, MEASURING VALUING HL, P83 Brazier JE, 2010, EUR J HEALTH ECON, V11, P215, DOI 10.1007/s10198-009-0168-z Brazier JE, 2004, MED CARE, V42, P851, DOI 10.1097/01.mlr.0000135827.18610.0d Briggs AH, 2000, PHARMACOECONOMICS, V17, P479, DOI 10.2165/00019053-200017050-00006 Brouwer WBF, 2008, J HEALTH ECON, V27, P325, DOI 10.1016/j.jhealeco.2007.07.003 Buysse CMP, 2008, ARCH PEDIAT ADOL MED, V162, P1036, DOI 10.1001/archpedi.162.11.1036 Centers for Disease Control and Prevention, 2012, SURVEILLANCE SUMMARI, V61, P1 Chapman RH, 2004, HEALTH ECON, V13, P429, DOI 10.1002/hec.853 Crott R, 2010, EUR J HEALTH ECON, V11, P427, DOI 10.1007/s10198-010-0233-7 Dakin H, 2010, QUAL LIFE RES, V19, P65, DOI 10.1007/s11136-009-9558-z Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958 Dekker MC, 2002, J INTELL DISABIL RES, V46, P61, DOI 10.1046/j.1365-2788.2002.00353.x EuroQol Group, 1990, HLTH POLICY, V16, P199, DOI DOI 10.1016/0168-8510(90)90421-9 Feeny D, 2002, MED CARE, V40, P113, DOI 10.1097/00005650-200202000-00006 Glasgow R. E., 2012, DISSEMINATION IMPLEM, P72 Glasgow RE, 2012, AM J PUBLIC HEALTH, V102, P1274, DOI 10.2105/AJPH.2012.300755 Glasgow RE, 2013, JNCI-J NATL CANCER I, V105, P766, DOI 10.1093/jnci/djt066 Gold MR, 1996, COST EFFECTIVENESS H Goldsmith KA, 2010, HEALTH QUAL LIFE OUT, V8, DOI 10.1186/1477-7525-8-54 Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Greenberg D, 2011, EXPERT REV PHARM OUT, V11, P113, DOI [10.1586/erp.11.1, 10.1586/ERP.11.1] Grosse SD, 2010, EXPERT REV PHARM OUT, V10, P293, DOI [10.1586/erp.10.24, 10.1586/ERP.10.24] Horsman John, 2003, Health Qual Life Outcomes, V1, P54, DOI 10.1186/1477-7525-1-54 Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41 Interagency Autism Coordinating Committee, 2011, 2011 IACC STRAT PLAN Khan KA, 2014, PHARMACOECONOMICS, V32, P693, DOI 10.1007/s40273-014-0153-y Kohavi R., 1995, INT JOINT C ART INT, V14, P1137 Kuhlthau K, 2010, J AUTISM DEV DISORD, V40, P721, DOI 10.1007/s10803-009-0921-2 Lipscomb J, 2009, VALUE HEALTH, V12, pS18, DOI 10.1111/j.1524-4733.2009.00518.x Long S., 2000, AM STAT, V54, P217 Longworth Louise, 2005, Eur J Health Econ, V6, P347, DOI 10.1007/s10198-005-0309-y Longworth L. J., 2011, 10 NICE DSU SCHARR U Lord C, 2010, SOCIAL POLICY REPORT, V24, P1 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lord C., 2001, ED CHILDR AUT Luo N, 2010, MED CARE, V48, P365, DOI 10.1097/MLR.0b013e3181c162a2 Meltzer DO, 2012, HBK ECON, P433, DOI 10.1016/B978-0-444-53592-4.00007-4 Mullen E., 1997, MULLEN SCALES EARLY Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362 National Autism Center, 2009, NAT STAND REP National Institute for Health and Care Excellence, 2013, GUID METH TECHN APPR National Institute for Health and Clinical Excellence (NICE), 2008, GUID METH TECHN APPR Neumann PJ, 2009, HEALTH AFFAIR, V28, P1366, DOI 10.1377/hlthaff.28.5.1366 Neumann PJ, 2000, ANNU REV PUBL HEALTH, V21, P587, DOI 10.1146/annurev.publhealth.21.1.587 Payakachat N, 2009, QUAL LIFE RES, V18, P801, DOI 10.1007/s11136-009-9499-6 Payakachat N, 2012, EXPERT REV PHARM OUT, V12, P485, DOI [10.1586/erp.12.29, 10.1586/ERP.12.29] Petrou S, 2010, BRIT J PSYCHIAT, V197, P395, DOI 10.1192/bjp.bp.110.081307 Petrou S, 2009, MED DECIS MAKING, V29, P291, DOI 10.1177/0272989X08327398 Pregibon D, 1980, APPLIED STATISTICS, V29, P15, DOI 10.2307/2346405 Prince FHM, 2010, ANN RHEUM DIS, V69, P138, DOI 10.1136/ard.2009.111260 Prosser LA, 2012, GENET MED, V14, P703, DOI 10.1038/gim.2012.24 Prosser LA, 2007, PHARMACOECONOMICS, V25, P713, DOI 10.2165/00019053-200725090-00001 Pullenayegum EM, 2010, VALUE HEALTH, V13, P487, DOI 10.1111/j.1524-4733.2010.00695.x RAMSEY JB, 1969, J ROY STAT SOC B, V31, P350 Roid G. H., 2003, STANFORD BINET INTEL Rothenberg B., 2009, TECHNOLOGY EVALUATIO, V23, P1 SAS Institute Inc, 2011, SAS STAT 9 3 US GUID, P4610 Scottish Intercollegiate Guidelines Network, 2007, SIGN PUBL Seiber W. J., 2008, QUALITY WELL BEING S Shumway S, 2012, AUTISM RES, V5, P267, DOI 10.1002/aur.1238 Sparrow SS, 2005, VINELAND ADAPTIVE BE Stevens K., 2010, PHARMACOECONOMICS, V30, P729 Tilford J. M., 2012, PHARMACOECONOMICS, V30, P1 Ungar W. J., 2010, EC EVALUATION CHILD Ungar Wendy J, 2007, Healthc Q, V10, P134 Ungar WJ, 2011, PHARMACOECONOMICS, V29, P641, DOI 10.2165/11591570-000000000-00000 Varni JW, 2001, MED CARE, V39, P800, DOI 10.1097/00005650-200108000-00006 Varni JW, 2003, AMBUL PEDIATR, V3, P329, DOI 10.1367/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2 Versteegh MM, 2010, HEALTH QUAL LIFE OUT, V8, DOI 10.1186/1477-7525-8-141 Versteegh MM, 2012, MED DECIS MAKING, V32, P554, DOI 10.1177/0272989X11427761 Wallander JL, 2006, J INTELL DISABIL RES, V50, P259, DOI 10.1111/j.1365-2788.2005.00792.x Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426 Weinstein MC, 1996, JAMA-J AM MED ASSOC, V276, P1253, DOI 10.1001/jama.276.15.1253 Wille N, 2010, QUAL LIFE RES, V19, P875, DOI 10.1007/s11136-010-9648-y NR 81 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 649 EP 663 DI 10.1002/aur.1409 PG 15 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700002 PM 25255789 ER PT J AU McPhillips, M Finlay, J Bejerot, S Hanley, M AF McPhillips, Martin Finlay, Jennifer Bejerot, Susanne Hanley, Mary TI Motor Deficits in Children With Autism Spectrum Disorder: A Cross-Syndrome Study SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; specific language impairment; motor deficit; cross-syndrome ID DEVELOPMENTAL COORDINATION DISORDER; SCHOOL-AGE-CHILDREN; LANGUAGE IMPAIRMENT; ASPERGERS-SYNDROME; PERFORMANCE; SEVERITY; INFANTS; SPEECH; SKILLS; TASK AB Recent research suggests that children with autism spectrum disorder (ASD) experience some level of motor difficulty, and that this may be associated with social communication skills. However, other studies show that children with language impairments, but without the social communication problems, are at risk of motor difficulties as well. The aim of the present study was to determine if children with ASD have syndrome-specific motor deficits in comparison to children with specific language impairment (SLI). We used an independent groups design with three groups of children (8-10 years old) matched on age and nonverbal IQ: an ASD group, an SLI group, and a typically developing (TD) group. All of the children completed an individually administered, standardized motor assessment battery. We found that the TD group demonstrated significantly better motor skills than either the ASD or SLI groups. Detailed analyses of the motor subtests revealed that the ASD and SLI groups had very similar motor profiles across a range of fine and gross motor skills, with one exception. We conclude that children with ASD, and SLI, are at risk of clinically significant motor deficits. However, future behavioral and neurological studies of motor skills in children with ASD should include an SLI comparison group in order to identify possible autism-specific deficits. Autism Res2014, 7: 664-676. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [McPhillips, Martin; Finlay, Jennifer; Hanley, Mary] Queens Univ Belfast, Sch Psychol, Belfast BT7 1NN, Antrim, North Ireland. [Bejerot, Susanne] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden. RP McPhillips, M (reprint author), Queens Univ Belfast, Sch Psychol, Belfast BT7 1NN, Antrim, North Ireland. EM m.mcphillips@qub.ac.uk CR Allen G, 2004, BIOL PSYCHIAT, V56, P269, DOI 10.1016/j.biophsych.2004.06.005 American Psychiatric Association, 2000, DIAGN STAT MAN MENT American Psychiatric Association, 2013, DIAGN STAT MAN MENT BARTAK L, 1975, BRIT J PSYCHIAT, V126, P127, DOI 10.1192/bjp.126.2.127 Bishop D. V. M., 2003, CHILDRENS COMMUNICAT Bishop DVM, 2002, J CHILD PSYCHOL PSYC, V43, P917, DOI 10.1111/1469-7610.00114 Bruininks R. H., 1978, BRUININKS OSERETSKY Bruininks R. H., 2005, BRUININKS OSERETSKY Cairney J, 2010, CURR OPIN PSYCHIATR, V23, P324, DOI 10.1097/YCO.0b013e32833aa0aa Conners CK, 2008, CONNERS Constantino JN, 2005, SOCIAL RESPONSIVENES Conti-Ramsden G, 2006, J CHILD PSYCHOL PSYC, V47, P621, DOI 10.1111/j.1469-7610.2005.01584.x DENCKLA MB, 1985, PSYCHOPHARMACOL BULL, V21, P773 Department of Education Northern Ireland, 2010, PERC PUP ENT FREE SC Dewey D, 2007, J INT NEUROPSYCH SOC, V13, P246, DOI 10.1017/S1355617707070270 Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734 Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149 Finlay JCS, 2013, RES DEV DISABIL, V34, P2533, DOI 10.1016/j.ridd.2013.05.015 Frith U., 2003, AUTISM EXPLAINING EN Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P43, DOI 10.1046/j.1365-2788.1998.00065.x Gilger JW, 2001, DEV NEUROPSYCHOL, V20, P465, DOI 10.1207/S15326942DN2002_2 Gillberg C, 2010, RES DEV DISABIL, V31, P1543, DOI 10.1016/j.ridd.2010.06.002 Green D, 2009, DEV MED CHILD NEUROL, V51, P311, DOI 10.1111/j.1469-8749.2008.03242.x Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054 Henderson S, 2007, MOVEMENT ASSESSMENT, V2nd Henderson W., 1992, MOVEMENT ASSESSMENT Hill EL, 1998, DEV MED CHILD NEUROL, V40, P388 Hill EL, 2001, INT J LANG COMM DIS, V36, P149, DOI 10.1080/13682820010019874 Hilton C, 2007, RES AUTISM SPECT DIS, V1, P339, DOI 10.1016/j.rasd.2006.12.003 Hilton CL, 2012, AUTISM, V16, P430, DOI 10.1177/1362361311423018 Iverson JM, 2010, J CHILD LANG, V37, P229, DOI 10.1017/S0305000909990432 Iverson JM, 2011, J SPEECH LANG HEAR R, V54, P72, DOI 10.1044/1092-4388(2010/08-0197) Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y Kadesjo B, 2001, J CHILD PSYCHOL PSYC, V42, P487, DOI 10.1017/S0021963001007090 Kaplan BJ, 1998, HUM MOVEMENT SCI, V17, P471, DOI 10.1016/S0167-9457(98)00010-4 Karmiloff-Smith A., 2012, NEURODEVELOPMENAL DI, P37 Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x Leonard HC, 2014, EUR J DEV PSYCHOL, V11, P18, DOI 10.1080/17405629.2013.801626 Leyfer OT, 2008, AUTISM RES, V1, P284, DOI 10.1002/aur.43 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 MacDonald M, 2013, ADAPT PHYS ACT Q, V30, P271 Mandelbaum DE, 2006, DEV MED CHILD NEUROL, V48, P33, DOI 10.1017/S0012162206000089 McPhillips M, 2007, J CHILD PSYCHOL PSYC, V48, P1214, DOI 10.1111/j.1469-7610.2007.01814.x Mostofsky SH, 2007, BRAIN, V130, P2117, DOI 10.1093/brain/awm129 Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088 Mullen E, 1995, MULLEN SCALES EARLY Noterdaeme M, 2002, EUR CHILD ADOLES PSY, V11, P219, DOI 10.1007/s00787-002-0285-z Penn HE, 2006, CHILD NEUROPSYCHOL, V12, P57, DOI 10.1080/09297040500253546 Piven J, 1997, AM J PSYCHIAT, V154, P1051 Rechetinikov RP, 2009, AM J OCCUP THER, V63, P255 Sparrow SS, 2005, VINELAND ADAPTIVE BE Ulrich D. A., 2000, TEST GROSS MOTOR DEV Wechsler D., 2006, WECHSLER NONVERBAL S Whitehouse AJO, 2007, J CHILD PSYCHOL PSYC, V48, P822, DOI 10.1111/j.1469-7610.2007.01765.x Williams H. G., 2004, J AUTISM DEV DISORD, V34, P285 Williams K. T., 2007, EXPRESSIVE VOCABULAR NR 57 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 664 EP 676 DI 10.1002/aur.1408 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700003 PM 25258309 ER PT J AU Green, AE Kenworthy, L Mosner, MG Gallagher, NM Fearon, EW Balhana, CD Yerys, BE AF Green, Adam E. Kenworthy, Lauren Mosner, Maya G. Gallagher, Natalie M. Fearon, Edward W. Balhana, Carlos D. Yerys, Benjamin E. TI Abstract Analogical Reasoning in High-Functioning Children with Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; analogical reasoning; development; social cognition ID LATENT SEMANTIC ANALYSIS; EXECUTIVE FUNCTION; YOUNG-CHILDREN; COMMUNICATION DEFICITS; RELATIONAL SHIFT; JOINT ATTENTION; WISC-IV; TASK; INTELLIGENCE; INDIVIDUALS AB Children with autism spectrum disorders (ASD) exhibit a deficit in spontaneously recognizing abstract similarities that are crucial for generalizing learning to new situations. This may contribute to deficits in the development of appropriate schemas for navigating novel situations, including social interactions. Analogical reasoning is the central cognitive mechanism that enables typically developing children to understand abstract similarities between different situations. Intriguingly, studies of high-functioning children with ASD point to a relative cognitive strength in basic, nonabstract forms of analogical reasoning. If this analogical reasoning ability extends to abstract analogical reasoning (i.e., between superficially dissimilar situations), it may provide a bridge between a cognitive capability and core ASD deficits in areas such as generalization and categorization. This study tested whether preserved analogical reasoning abilities in ASD can be extended to abstract analogical reasoning, using photographs of real-world items and situations. Abstractness of the analogies was determined via a quantitative measure of semantic distance derived from latent semantic analysis. Children with ASD performed as well as typically developing children at identifying abstract analogical similarities when explicitly instructed to apply analogical reasoning. Individual differences in abstract analogical reasoning ability predicted individual differences in a measure of social function in the ASD group. Preliminary analyses indicated that children with ASD, but not typically developing children, showed an effect of age on abstract analogical reasoning. These results provide new evidence that children with ASD are capable of identifying abstract similarities through analogical reasoning, pointing to abstract analogical reasoning as a potential lever for improving generalization skills and social function in ASD. Autism Res2014, 7: 677-686. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Green, Adam E.; Gallagher, Natalie M.; Fearon, Edward W.] Georgetown Univ, Dept Psychol, Washington, DC 20057 USA. [Kenworthy, Lauren] Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, Washington, DC 20010 USA. [Mosner, Maya G.; Yerys, Benjamin E.] Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA. [Balhana, Carlos D.] MITRE, Mclean, VA USA. RP Green, AE (reprint author), Georgetown Univ, Dept Psychol, 302C White Gravenor Hall,3700 O St NW,Box 571001, Washington, DC 20057 USA. EM aeg58@Georgetown.edu FU NIMH [5K23MH086111, 1R21MH092615, 1RC1MH088791]; Pennsylvania Department of Health (SAP) [4100042728, 4100047863]; Pfizer; Robert Wood Johnson Foundation [66727]; Isadore and Bertha Gudelsky Foundation; American Legacy Foundation FX We would like to thank the families for the time and effort in completing this study. This research was sponsored in part by the NIMH (5K23MH086111 and 1R21MH092615 to B.E. Yerys and 1RC1MH088791 to R. Schultz), a grant from the Pennsylvania Department of Health (SAP #4100042728 and 4100047863, to R. Schultz), a grant from Pfizer (to R. Schultz), a grant from the Robert Wood Johnson Foundation (#66727 to R. Schultz), a grant from the Isadore and Bertha Gudelsky Foundation (to L. Kenworthy), and grants from The American Legacy Foundation and Partners in Research (to A.E. Green). CR Alderson-Day B, 2011, J AUTISM DEV DISORD, V41, P555, DOI 10.1007/s10803-010-1077-9 (APA) APA, 2000, DIAGN STAT MAN MENT Bolte S, 2009, J AUTISM DEV DISORD, V39, P678, DOI 10.1007/s10803-008-0667-2 Brown SM, 2012, RES AUTISM SPECT DIS, V6, P733, DOI 10.1016/j.rasd.2011.10.012 Committee I. A. C., 2012, INT AUT COORD COMM S Constantino JN, 2005, SOCIAL RESPONSIVENES Dawson G, 1998, CHILD DEV, V69, P1276, DOI 10.2307/1132265 Dawson G, 2002, CHILD DEV, V73, P345, DOI 10.1111/1467-8624.00411 Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481 Elliott C., 2007, DIFFERENTIAL ABILITY Frith U., 1989, AUTISM EXPLAINING EN Gadow K. D., 2000, CHILDHOOD SYMPTOM IN Gentner D, 1998, COGNITION, V65, P263, DOI 10.1016/S0010-0277(98)00002-X GENTNER D, 1988, CHILD DEV, V59, P47, DOI 10.2307/1130388 GICK ML, 1983, COGNITIVE PSYCHOL, V15, P1, DOI 10.1016/0010-0285(83)90002-6 GOSWAMI U, 1991, CHILD DEV, V62, P1 GOSWAMI U, 1990, COGNITION, V35, P69, DOI 10.1016/0010-0277(90)90037-K Green AE, 2012, INTELLIGENCE, V40, P598, DOI 10.1016/j.intell.2012.08.005 Green AE, 2012, J EXP PSYCHOL LEARN, V38, P264, DOI 10.1037/a0025764 Green AE, 2006, MEM COGNITION, V34, P1414, DOI 10.3758/BF03195906 Green AE, 2010, CEREB CORTEX, V20, P70, DOI 10.1093/cercor/bhp081 Green AE, 2008, COGNITION, V106, P1004, DOI 10.1016/j.cognition.2007.03.015 Gresham F. M., 2008, SOCIAL SKILLS IMPROV Griffith EM, 1999, CHILD DEV, V70, P817, DOI 10.1111/1467-8624.00059 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Holyoak KJ, 1995, MENTAL LEAPS Landau MJ, 2010, PSYCHOL BULL, V136, P1045, DOI 10.1037/a0020970 Landauer TK, 1998, DISCOURSE PROCESS, V25, P259 Landauer TK, 1997, PSYCHOL REV, V104, P211, DOI 10.1037/0033-295X.104.2.211 Lawrence EJ, 2012, J NERV MENT DIS, V200, P796, DOI 10.1097/NMD.0b013e318266ba2b Liu JH, 1997, INT J PSYCHOL, V32, P73 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030 Mayes SD, 2008, J AUTISM DEV DISORD, V38, P428, DOI 10.1007/s10803-007-0410-4 MCEVOY RE, 1993, J CHILD PSYCHOL PSYC, V34, P563, DOI 10.1111/j.1469-7610.1993.tb01036.x Morsanyi K, 2010, DEVELOPMENTAL SCI, V13, P578, DOI 10.1111/j.1467-7687.2009.00915.x Morsanyi K, 2012, J AUTISM DEV DISORD, V42, P2297, DOI 10.1007/s10803-012-1477-0 O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527 Oliveras-Rentas RE, 2012, J AUTISM DEV DISORD, V42, P655, DOI 10.1007/s10803-011-1289-7 Ozonoff S, 2004, J AUTISM DEV DISORD, V34, P139, DOI 10.1023/B:JADD.0000022605.81989.cc Pellicano E, 2010, CHILD DEV, V81, P1400, DOI 10.1111/j.1467-8624.2010.01481.x Plaisted K, 2003, PHILOS T ROY SOC B, V358, P375, DOI 10.1098/rstb.2002.1211 Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489 Rattermann MJ, 1998, COGNITIVE DEV, V13, P453, DOI 10.1016/S0885-2014(98)90003-X Raven J.C., 1965, ADV PROGR MATRICES S READ SJ, 1987, J EXP SOC PSYCHOL, V23, P189, DOI 10.1016/0022-1031(87)90031-X Richland LE, 2013, PSYCHOL SCI, V24, P87, DOI 10.1177/0956797612450883 Rosenthal M, 2013, NEUROPSYCHOLOGY, V27, P13, DOI 10.1037/a0031299 Scott FJ, 1996, DEV PSYCHOPATHOL, V8, P235 SHULMAN C, 1995, J ABNORM PSYCHOL, V104, P601, DOI 10.1037//0021-843X.104.4.601 SMITH ER, 1984, PSYCHOL REV, V91, P392, DOI 10.1037//0033-295X.91.3.392 Sobel DM, 2005, BRIT J DEV PSYCHOL, V23, P159, DOI 10.1348/026151004X02694 Sprafkin J., 2010, CHILD ADOLESCENT SYM Stahl L, 2002, AUTISM, V6, P383, DOI 10.1177/1362361302006004005 Wallace GL, 2009, J AUTISM DEV DISORD, V39, P1735, DOI 10.1007/s10803-009-0802-8 Wass S. V., 2013, AUTISM INT J RES PRA, DOI [10.1177/1362361313499827, DOI 10.1177/1362361313499827] Wechsler D., 2003, WECHSLER SCALES INTE Wechsler D, 1999, WECHSLER ABBREVIATED Yerys BE, 2012, J AUTISM DEV DISORD, V42, P2013, DOI 10.1007/s10803-012-1443-x Yerys BE, 2007, J AUTISM DEV DISORD, V37, P1068, DOI 10.1007/s10803-006-0250-7 NR 62 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 677 EP 686 DI 10.1002/aur.1411 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700004 PM 25255899 ER PT J AU Bavin, EL Kidd, E Prendergast, L Baker, E Dissanayake, C Prior, M AF Bavin, Edith L. Kidd, Evan Prendergast, Luke Baker, Emma Dissanayake, Chery Prior, Margot TI Severity of Autism is Related to Children's Language Processing SO AUTISM RESEARCH LA English DT Article DE lexical processing; severity of ASD; eye tracking; children ID SPECTRUM DISORDERS; WORD RECOGNITION; EYE-MOVEMENTS; COMPREHENSION AB Problems in language processing have been associated with autism spectrum disorder (ASD), with some research attributing the problems to overall language skills rather than a diagnosis of ASD. Lexical access was assessed in a looking-while-listening task in three groups of 5- to 7-year-old children; two had high-functioning ASD (HFA), an ASD severe (ASD-S) group (n=16) and an ASD moderate (ASD-M) group (n=21). The third group were typically developing (TD) (n=48). Participants heard sentences of the form Where's the x? and their eye movements to targets (e.g., train), phonological competitors (e.g., tree), and distractors were recorded. Proportions of looking time at target were analyzed within 200ms intervals. Significant group differences were found between the ASD-S and TD groups only, at time intervals 1000-1200 and 1200-1400ms postonset. The TD group was more likely to be fixated on target. These differences were maintained after adjusting for language, verbal and nonverbal IQ, and attention scores. An analysis using parent report of autistic-like behaviors showed higher scores to be associated with lower proportions of looking time at target, regardless of group. Further analysis showed fixation for the TD group to be significantly faster than for the ASD-S. In addition, incremental processing was found for all groups. The study findings suggest that severity of autistic behaviors will impact significantly on children's language processing in real life situations when exposed to syntactically complex material. They also show the value of using online methods for understanding how young children with ASD process language. Autism Res2014, 7: 687-694. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Bavin, Edith L.; Baker, Emma; Dissanayake, Chery] La Trobe Univ, Sch Psychol Sci, Melbourne, Vic 3083, Australia. [Kidd, Evan] Australian Natl Univ, Res Sch Psychol, ARC Ctr Excellence Dynam Language, Canberra, ACT, Australia. [Prendergast, Luke] La Trobe Univ, Dept Math & Stat, Melbourne, Vic 3083, Australia. [Baker, Emma; Dissanayake, Chery; Prior, Margot] La Trobe Univ, Olga Tennison Autism Res Ctr, Melbourne, Vic 3083, Australia. [Prior, Margot] Univ Melbourne, Sch Psychol Sci, Melbourne, Vic, Australia. RP Bavin, EL (reprint author), La Trobe Univ, Sch Psychol Sci, Melbourne, Vic 3083, Australia. EM e.bavin@latrobe.edu.au FU Australian Research Council [DP 1092668] FX We thank the schools and agencies who helped in recruitment, the children who participated, and Cherie Green who conducted the ADOS assessment. Grant Sponsor: The Australian Research Council; Grant Number: DP 1092668. CR Allopenna PD, 1998, J MEM LANG, V38, P419, DOI 10.1006/jmla.1997.2558 Altmann GTM, 1999, COGNITION, V73, P247, DOI 10.1016/S0010-0277(99)00059-1 Brock J, 2008, COGNITION, V108, P896, DOI 10.1016/j.cognition.2008.06.007 COLTHEART M, 1981, Q J EXP PSYCHOL-A, V33, P497 Frith U., 1989, AUTISM EXPLAINING EN Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Groen W. B., 2012, AUTISM RES TREATMENT, V83, P926 HAPPE FGE, 1994, J CHILD PSYCHOL PSYC, V35, P1461, DOI 10.1111/j.1469-7610.1994.tb01287.x Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Hojsgaard S., 2006, J STAT SOFTW, V15, P1 Kamio Y, 2000, J CHILD PSYCHOL PSYC, V41, P859, DOI 10.1017/S0021963099006137 Korkman M., 2007, NEPSY 2 DEV NEUROPSY Leech G., 2001, WORD FREQUENCIES WRI Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 R Core Team, 2013, R LANG ENV STAT COMP Rutter M., 2003, SOCIAL COMMUNICATION Sattler J. M, 2004, ASSESSMENT CHILDREN Semel E., 2003, CLIN EVALUATION LANG, V4th Swingley D, 1999, COGNITION, V71, P73, DOI 10.1016/S0010-0277(99)00021-9 Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, V1, P335 Thothathiri M, 2008, COGNITION, V108, P51, DOI 10.1016/j.cognition.2007.12.012 Thothathiri M, 2008, J MEM LANG, V58, P188, DOI 10.1016/j.jml.2007.06.012 Wechsler D., 2002, WESCHLER PRESCHOOL P, V3rd Wechsler D., 2003, WESCHLER INTELLIGENC Wiggins L. D., 2007, FOCUS AUTISM OTHER D, V22, P33, DOI [10.1177/10883576070220010401, DOI 10.1177/10883576070220010401] Yan J., 2004, STAT MED, V23, P12 NR 28 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 687 EP 694 DI 10.1002/aur.1410 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700005 PM 25262588 ER PT J AU Singleton, CJ Ashwin, C Brosnan, M AF Singleton, Clarence J. Ashwin, Chris Brosnan, Mark TI Physiological Responses to Social and Nonsocial Stimuli in Neurotypical Adults With High and Low Levels of Autistic Traits: Implications for Understanding Nonsocial Drive in Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE AQ; Autism Spectrum Disorder; non-social psychophysiology; social cognition ID FUSIFORM FACE AREA; SKIN-CONDUCTANCE RESPONSES; HIGH-FUNCTIONING AUTISM; MALE BRAIN THEORY; ASPERGER-SYNDROME; AMYGDALA THEORY; CHILDREN; ACTIVATION; GAZE; PERCEPTION AB Researchers have suggested that the two primary cognitive features of autism spectrum disorder (ASD), a drive toward nonsocial processing and a reduced drive toward social processing, may be unrelated to each other in the neurotypical (NT) population and may therefore require separate explanations. Drive toward types of processing may be related to physiological arousal to categories of stimuli, such as social (e.g., faces) or nonsocial (e.g., trains). This study investigated how autistic traits in an NT population might relate to differences in physiological responses to nonsocial compared with social stimuli. NT participants were recruited to examine these differences in those with high vs. low degrees of ASD traits. Forty-six participants (21 male, 25 female) completed the Autism Spectrum Quotient (AQ) to measure ASD traits before viewing a series of 24 images while skin conductance response (SCR) was recorded. Images included six nonsocial, six social, six face-like cartoons, and six nonsocial (relating to participants' personal interests). Analysis revealed that those with a higher AQ had significantly greater SCR arousal to nonsocial stimuli than those with a low AQ, and the higher the AQ, the greater the difference between SCR arousal to nonsocial and social stimuli. This is the first study to identify the relationship between AQ and physiological response to nonsocial stimuli, and a relationship between physiological response to both social and nonsocial stimuli, suggesting that physiological response may underlie the atypical drive toward nonsocial processing seen in ASD, and that at the physiological level at least the social and nonsocial in ASD may be related to one another. Autism Res2014, 7: 695-703. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Singleton, Clarence J.; Ashwin, Chris; Brosnan, Mark] Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England. RP Singleton, CJ (reprint author), Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England. EM c.j.singleton@bath.ac.uk CR American Psychiatric Association, 2013, DSM5 PROPOSED CRITER Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014 Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337 Baron-Cohen S., 2001, J DEV LEARNING DISOR, V5, P47 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7 Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6 Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206 Biopac Systems Inc., 2012, APPLICATION NOTE AH Blair RJR, 1999, PERS INDIV DIFFER, V26, P477, DOI 10.1016/S0191-8869(98)00154-8 Bookheimer SY, 2008, J INT NEUROPSYCH SOC, V14, P922, DOI 10.1017/S135561770808140X Boucher Jill, 2005, Cogn Neuropsychiatry, V10, P165, DOI 10.1080/13546800444000038 Breska A., 2010, PSYCHOPHYSIOLOGY, V48, P437, DOI DOI 10.1111/J.1469-8986.2010.01084.X Brosnan M, 2010, J AUTISM DEV DISORD, V40, P1, DOI 10.1007/s10803-009-0815-3 Brosnan M., 2013, INTERNATIONAL MEETIN Brosnan M, 2014, J AUTISM DEV DISORD, V44, P513, DOI 10.1007/s10803-013-1897-5 Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27 Caria A, 2011, CEREB CORTEX, V21, P2838, DOI 10.1093/cercor/bhr084 Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Damasio AR, 1996, PHILOS T R SOC B, V351, P1413, DOI 10.1098/rstb.1996.0125 Dawson ME, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P159 Gaigg SB, 2007, NEUROPSYCHOLOGIA, V45, P2125, DOI 10.1016/j.neuropsychologia.2007.01.012 Greenwald M.K., 1989, J PSYCHOPHYSIOL, V3, P51 Grelotti DJ, 2005, NEUROPSYCHOLOGIA, V43, P373, DOI 10.1016/j.neuropsychologia.2004.06.015 Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 Heaton P, 1998, MUSIC PERCEPT, V15, P291 Hobson R. P., 2006, MONOGRAPHS SOC RES C, V284, P71 Howard MA, 2000, NEUROREPORT, V11, P2931, DOI 10.1097/00001756-200009110-00020 Hubert BE, 2009, AUTISM, V13, P9, DOI 10.1177/1362361308091649 JAMES A L, 1984, International Journal of Psychophysiology, V1, P179, DOI 10.1016/0167-8760(84)90037-0 Jarrold C, 2005, DEVELOPMENTAL SCI, V8, P344, DOI 10.1111/j.1467-7687.2005.00422.x Kanwisher N, 1997, J NEUROSCI, V17, P4302 Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4 Levitin Daniel J., 2006, THIS IS YOUR BRAIN O Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059 Ronald A, 2005, DEVELOPMENTAL SCI, V8, P444, DOI 10.1111/j.1467-7687.2005.00433.x Schultz RT, 2003, PHILOS T ROY SOC B, V358, P415, DOI 10.1098/rstb.2002.1208 Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Screbo A., 1992, PSYCHOPHYSIOLOGY, V29, P241 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x Singleton C.J., 2012, OBJECTS OF SOCIAL NO South M, 2008, J INT NEUROPSYCH SOC, V14, P42, DOI 10.1017/S1355617708080107 South M, 2005, J AUTISM DEV DISORD, V35, P145, DOI 10.1007/s10803-005-1992-3 Stagg SD, 2013, J AUTISM DEV DISORD, V43, P2303, DOI 10.1007/s10803-013-1780-4 Venables P.H., 1980, TECHNIQUES PSYCHOPHY, P3 Williams D, 2010, AUTISM, V14, P285, DOI 10.1177/1362361309344849 NR 49 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 695 EP 703 DI 10.1002/aur.1422 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700006 PM 25346292 ER PT J AU Zwicker, JD Emery, JCH AF Zwicker, Jennifer D. Emery, J. C. Herbert TI Autism Research Funding Allocation: Can Economics Tell Us If We Have Got It Right? SO AUTISM RESEARCH LA English DT Article DE autism; research funding; economic evaluation; funding allocation AB There is a concern that the allocation of autism spectrum disorder (ASD) research funding may be misallocating resources, overemphasizing basic science at the expense of translational and clinical research. Anthony Bailey has proposed that an economic evaluation of autism research funding allocations could be beneficial for funding agencies by identifying under- or overfunded areas of research. In response to Bailey, we illustrate why economics cannot provide an objective, technical solution for identifying the best allocation of research resources. Economic evaluation has its greatest power as a late-stage research tool for interventions with identified objectives, outcomes, and data. This is not the case for evaluating whether research areas are over- or underfunded. Without an understanding of how research funding influences the likelihood and value of a discovery, or without a statement of the societal objectives for ASD research and level of risk aversion, economic analysis cannot provide a useful normative evaluation of ASD research. Autism Res2014, 7: 704-711. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Zwicker, Jennifer D.] Univ Calgary, Sch Publ Policy, Calgary, AB T2P 1H9, Canada. [Emery, J. C. Herbert] Univ Calgary, Dept Econ, Calgary, AB T2P 1H9, Canada. RP Zwicker, JD (reprint author), Univ Calgary, Sch Publ Policy, Downtown Campus,906 8th Ave SW,5th Floor, Calgary, AB T2P 1H9, Canada. EM zwicker1@ucalgary.ca FU Alberta Innovates Health Solutions [10003547] FX Grant sponsor Alberta Innovates Health Solutions; Grant number: 10003547. CR Ades AE, 2006, PHARMACOECONOMICS, V24, P1, DOI 10.2165/00019053-200624010-00001 Bailey AJ, 2009, AUTISM RES, V2, P245, DOI 10.1002/aur.99 Baron-Cohen Simon, 1997, MINDBLINDNESS ESSAY Bauman MD, 2013, NEUROPSYCHIATRY-LOND, V3, P159, DOI 10.2217/NPY.13.18 Best MA, 2005, J ROY STAT SOC A STA, V168, P261, DOI 10.1111/j.1467-985X.2004.00347_17.x BLACKORBY C, 1992, ECON J, V102, P1345, DOI 10.2307/2234794 Coalition to Protect Research, 2007, NIH RES PRIOR Q A Collier R, 2010, CAN MED ASSOC J, V182, pE619, DOI 10.1503/cmaj.109-3280 Doyle Carolyn A, 2012, Dialogues Clin Neurosci, V14, P263 Fox J., 1999, WHAT WORLD HAPPENED Godlee F, 2011, BRIT MED J, V342, DOI 10.1136/bmj.c7452 Health Economics Research Group, 2008, MED RES WHATS IT WOR Interagency Autism Coordinating Committee, 2012, 2010 AUT SPECTR DIS Lenaway D, 2006, AM J PUBLIC HEALTH, V96, P410, DOI 10.2105/AJPH.2004.046037 Little RJ, 2006, AM STAT, V60, P213, DOI 10.1198/000313006X117837 Morris ZS, 2011, J ROY SOC MED, V104, P510, DOI 10.1258/jrsm.2011.110180 Pellicano E, 2014, AUTISM, V18, P756, DOI 10.1177/1362361314529627 Pellicano L., 2013, FUTURE MADE TOGETHER Silverman C, 2007, ARCH PEDIAT ADOL MED, V161, P392, DOI 10.1001/archpedi.161.4.392 Singh J, 2009, J AUTISM DEV DISORD, V39, P788, DOI 10.1007/s10803-008-0685-0 Spiegelhalter DJ, 2004, STAT SCI, V19, P156, DOI 10.1214/088342304000000080 Stokstad E, 2007, SCIENCE, V315, P27 Sugden R., 1978, PRINCIPLES PRACTICAL Ward V, 2009, J HEALTH SERV RES PO, V14, P156, DOI 10.1258/jhsrp.2009.008120 NR 24 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 704 EP 711 DI 10.1002/aur.1423 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700007 PM 25288440 ER PT J AU Elmose, M Happe, F AF Elmose, Mette Happe, Francesca TI Being Aware of Own Performance: How Accurately Do Children With Autism Spectrum Disorder Judge Own Memory Performance? SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; self-awareness; meta-memory; theory of mind ID VISUAL MEMORY; ADULTS; MIND; FRACTIONATION; JUDGMENTS; RECALL; SELF AB Self-awareness was investigated by assessing accuracy of judging own memory performance in a group of children with autism spectrum disorder (ASD) compared with a group of typically developing (TD) children. Effects of stimulus type (social vs. nonsocial), and availability of feedback information as the task progressed, were examined. Results overall showed comparable levels and patterns of accuracy in the ASD and TD groups. A trend level effect (p = 061, d=0.60) was found, with ASD participants being more accurate in judging own memory for nonsocial than social stimuli and the opposite pattern for TD participants. These findings suggest that awareness of own memory can be good in children with ASD. It is discussed how this finding may be interpreted, and it is suggested that further investigation into the relation between content, frequency, and quality of self-awareness, and the context of self-awareness, is needed. Autism Res2014, 7: 712-719. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Elmose, Mette] Univ Southern Denmark, Dept Psychol, DK-5230 Odense M, Denmark. [Happe, Francesca] Inst Psychiat, MRC Social Genet Dev & Psychiat Res Ctr, London, England. RP Elmose, M (reprint author), Univ Southern Denmark, Dept Psychol, Campusvej 55, DK-5230 Odense M, Denmark. EM melandersen@health.sdu.dk CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT BARONCOHEN S, 1989, J AUTISM DEV DISORD, V19, P579, DOI 10.1007/BF02212859 Bebko J. M., 2000, AUTISM, V4, P299, DOI DOI 10.1177/1362361300004003006 Blair RJR, 2002, NEUROPSYCHOLOGIA, V40, P108, DOI 10.1016/S0028-3932(01)00069-0 Bowler D, 2007, AUTISM SPECTRUM DISO Bowler DM, 2004, J AUTISM DEV DISORD, V34, P533, DOI 10.1007/s10803-004-2548-7 Bowler DM, 2000, J AUTISM DEV DISORD, V30, P295, DOI 10.1023/A:1005575216176 Carruthers P, 2009, BEHAV BRAIN SCI, V32, P121, DOI 10.1017/S0140525X09000545 Cipolotti L, 1999, NEUROPSYCHOLOGIA, V37, P455, DOI 10.1016/S0028-3932(98)00086-4 Cohen J., 1988, STAT POWER ANAL BEHA, V2nd Farrant A, 1999, J AUTISM DEV DISORD, V29, P359, DOI 10.1023/A:1023074726548 Farrant A, 1999, CHILD DEV, V70, P107 Farrant A, 1998, J AUTISM DEV DISORD, V28, P43, DOI 10.1023/A:1026010919219 Fisher N., 2002, THESIS U LONDON LOND Frith U., 2003, AUTISM EXPLAINING EN Frith U, 1999, MIND LANG, V14, P1 Hala S, 2005, J AUTISM DEV DISORD, V35, P75, DOI 10.1007/s10803-004-1036-4 Happe F, 2003, ANN NY ACAD SCI, V1001, P134, DOI 10.1196/annals.1279.008 Karably K., 2009, INT ELECT J ELEMENTA, V2, P32 Kazak S, 1997, J CHILD PSYCHOL PSYC, V38, P1001, DOI 10.1111/j.1469-7610.1997.tb01617.x Kristensen OS, 2004, BRAIN INJURY, V18, P1049, DOI 10.1080/02699050410001672279 Loth E, 2010, NEUROPSYCHOLOGIA, V48, P1227, DOI 10.1016/j.neuropsychologia.2009.12.023 Luria A. R., 1973, WORKING BRAIN INTRO Minshew NJ, 2005, J AUTISM DEV DISORD, V35, P45, DOI 10.1007/s10803-004-1030-x Roebers CM, 2003, J EXP CHILD PSYCHOL, V85, P352, DOI 10.1016/S0022-0965(03)00076-6 Sattler J.M., 1992, ASSESSMENT CHILDREN Lockl K, 2002, INT J BEHAV DEV, V26, P327, DOI 10.1080/01650250143000210 Schneider W, 2000, COGNITIVE DEV, V15, P115, DOI 10.1016/S0885-2014(00)00024-1 Webb S. J., 2008, MEMORY AUTISM THEORI, P188, DOI 10.1017/CBO9780511490101.012 Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd Williams D, 2010, AUTISM, V14, P474, DOI 10.1177/1362361310366314 World Health Organisation, 1992, ICD 10 CLASS MENT BE NR 32 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 712 EP 719 DI 10.1002/aur.1421 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700008 PM 25339388 ER PT J AU Alderson-Day, B AF Alderson-Day, Ben TI Verbal Problem-Solving Difficulties in Autism Spectrum Disorders and Atypical Language Development SO AUTISM RESEARCH LA English DT Article DE developmental psychology; language development; executive function; problem solving; inner speech ID HIGH-FUNCTIONING AUTISM; ASPERGERS-SYNDROME; INNER SPEECH; HEARING INDIVIDUALS; EXECUTIVE CONTROL; CHILDREN; DEAF; CATEGORIZATION; IMPAIRMENT; ADULTS AB Children with autism spectrum disorders (ASDs) adopt less efficient strategies than typically developing (TD) peers on the Twenty Questions Task (TQT), a measure of verbal problem-solving skills. Although problems with the TQT are typically associated with executive dysfunction, they have also been reported in children who are deaf, suggesting a role for atypical language development. To test the contribution of language history to ASD problem solving, TQT performance was compared in children with high-functioning autism (HFA), children with Asperger syndrome (AS) and TD children. The HFA group used significantly less efficient strategies than both AS and TD children. No group differences were evident on tests of question understanding, planning or verbal fluency. Potential explanations for differences in verbal problem-solving skill are discussed with reference to the development of inner speech and use of visual strategies in ASD. Autism Res2014, 7: 720-730. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 Univ Durham, Dept Psychol, Sci Labs, Durham DH1 3LE, England. RP Alderson-Day, B (reprint author), Univ Durham, Dept Psychol, Sci Labs, South Rd, Durham DH1 3LE, England. EM benjamin.alderson-day@durham.ac.uk FU University of Edinburgh College of Humanities and Social Sciences Studentship; Wellcome Trust [WT098455] FX This research was completed as part of a doctoral degree by the author at the University of Edinburgh and supported by a University of Edinburgh College of Humanities and Social Sciences Studentship. Margaret McGonigle-Chalmers and Robert Logie are thanked for their help and support for the research. Thanks are also due to Charles Fernyhough for comments on the manuscript. The author declares no conflicts of interest.The author is currently supported by Wellcome Trust grant WT098455. CR Alderson-Day B, 2011, J AUTISM DEV DISORD, V41, P555, DOI 10.1007/s10803-010-1077-9 Alderson-Day B, 2011, AUTISM RES, V4, P401, DOI 10.1002/aur.222 American Psychiatric Association, 2013, DIAGN STAT MAN MENT American Psychiatric Association, 1994, DSM 4 DIAGN STAT MAN, V4th Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6 Bennett T, 2008, J AUTISM DEV DISORD, V38, P616, DOI 10.1007/s10803-007-0428-7 Blamey P. J., 2003, OXFORD HDB DEAF STUD, P232 Boucher J, 2012, J CHILD PSYCHOL PSYC, V53, P219, DOI 10.1111/j.1469-7610.2011.02508.x Channon S, 2001, J AUTISM DEV DISORD, V31, P461, DOI 10.1023/A:1012212824307 Davies DK, 2003, RES PRACT PERS SEV D, V28, P182, DOI 10.2511/rpsd.28.4.182 Delis DC, 2001, DELIS KAPLAN EXECUTI Dexter DD, 2011, LEARN DISABILITY Q, V34, P51 Diaz R.M., 1992, PRIVATE SPEECH SOCIA Farjardo I, 2008, J DEAF STUD DEAF EDU, V13, P241, DOI 10.1093/deafed/enm058 Fernyhough C, 1996, NEW IDEAS PSYCHOL, V14, P47, DOI 10.1016/0732-118X(95)00024-B Gaffrey MS, 2007, NEUROPSYCHOLOGIA, V45, P1672, DOI 10.1016/j.neuropsychologia.2007.01.008 Grandin T., 1995, LEARNING COGNITION A, P137 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Hauser P. C., 2008, DEAF COGNITION FDN O, P286 Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001 Holland L, 2010, BRIT J DEV PSYCHOL, V28, P369, DOI 10.1348/026151009X424088 HORTON MS, 1980, CHILD DEV, V51, P708, DOI 10.1111/j.1467-8624.1980.tb02605.x Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Kamio Y, 2007, J AUTISM DEV DISORD, V37, P1116, DOI 10.1007/s10803-006-0254-3 Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7 KOH SD, 1971, J VERB LEARN VERB BE, V10, P542, DOI 10.1016/S0022-5371(71)80026-9 Kunda M, 2011, J AUTISM DEV DISORD, V41, P1157, DOI 10.1007/s10803-010-1137-1 Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0 Lidstone JSM, 2012, DEV PSYCHOPATHOL, V24, P651, DOI 10.1017/S0954579412000223 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Mackinlay R, 2006, BRAIN COGNITION, V61, P14, DOI 10.1016/j.bandc.2005.12.006 Manjiviona J., 1999, AUTISM, V3, P327, DOI DOI 10.1177/1362361399003004003 Marschark M., 1999, DEAFNESS ED INT, V1, P65, DOI 10.1002/dei.48 Marschark M, 2006, EUR J COGN PSYCHOL, V18, P70, DOI 10.1080/09541440500216028 Marschark M, 2004, AM ANN DEAF, V149, P51, DOI 10.1353/aad.2004.0013 Mayberry R. I., 2002, HDB NEUROPSYCHOLOG 2, V8, P71 Mayes SD, 2004, J DEV PHYS DISABIL, V16, P257, DOI 10.1023/B:JODD.0000032301.07550.0e McEvoy C, 1999, J EDUC PSYCHOL, V91, P312, DOI 10.1037/0022-0663.91.2.312 Miller GA, 2001, J ABNORM PSYCHOL, V110, P40, DOI 10.1037//0021-843X.110.1.40 Miller JN, 2000, J ABNORM PSYCHOL, V109, P227, DOI 10.1037/0021-843X.109.2.227 MINSHEW NJ, 1994, ARCH CLIN NEUROPSYCH, V9, P31, DOI 10.1016/0887-6177(94)90012-4 Minshew NJ, 2002, NEUROPSYCHOLOGY, V16, P327, DOI 10.1037//0894-4105.16.3.327 Mioshi E, 2006, INT J GERIATR PSYCH, V21, P1078, DOI 10.1002/gps.1610 Mitchell Ross, 2004, SIGN LANGUAGE STUDIE, V4, P138, DOI DOI 10.1353/SLS.2004.0005 Moeller MP, 2007, EAR HEARING, V28, P740 Mosher F. A., 1966, STUDIES COGNITIVE GR, P86 Newell A., 1972, HUMAN PROBLEM SOLVIN Ormel EA, 2010, J COMMUN DISORD, V43, P347, DOI 10.1016/j.jcomdis.2010.03.001 Ozonoff S., 2000, AUTISM, V4, P29, DOI DOI 10.1177/1362361300041003 RUMSEY JM, 1985, J AUTISM DEV DISORD, V15, P23, DOI 10.1007/BF01837896 Sahyoun CP, 2009, J AUTISM DEV DISORD, V39, P1014, DOI 10.1007/s10803-009-0712-9 Schneider W., 2002, E PRIME REFERENCE GU Semel E, 1995, CLIN EVALUATION LANG, V3rd Solomon M, 2004, J AUTISM DEV DISORD, V34, P649, DOI 10.1007/s10803-004-5286-y Soulieres I, 2009, HUM BRAIN MAPP, V30, P4082, DOI 10.1002/hbm.20831 Speirs S, 2011, AUTISM, V15, P307, DOI 10.1177/1362361310386501 Spek A, 2009, NEUROPSYCHOLOGIA, V47, P652, DOI 10.1016/j.neuropsychologia.2008.11.015 SZATMARI P, 1995, J AM ACAD CHILD PSY, V34, P1662, DOI 10.1097/00004583-199512000-00017 TAGERFLUSBERG H, 1985, J EXP CHILD PSYCHOL, V40, P450, DOI 10.1016/0022-0965(85)90077-3 UNGERER JA, 1987, J AUTISM DEV DISORD, V17, P3, DOI 10.1007/BF01487256 van den Bergh SFWM, 2014, J AUTISM DEV DISORD, V44, P1959, DOI 10.1007/s10803-014-2071-4 Verte S, 2006, J AUTISM DEV DISORD, V36, P351, DOI 10.1007/s10803-006-0074-5 Vygotsky L., 1987, THINKING SPEECH COLL Wallace GL, 2009, J AUTISM DEV DISORD, V39, P1735, DOI 10.1007/s10803-009-0802-8 Wechsler D, 1999, WECHSLER ABBREVIATED White SJ, 2009, AUTISM RES, V2, P138, DOI 10.1002/aur.78 Whitehouse AJO, 2006, J CHILD PSYCHOL PSYC, V47, P857, DOI 10.1111/j.1469-7610.2006.01624.x WHO, 1993, ICD 10 CLASS MENT BE Williams DM, 2012, DEV PSYCHOPATHOL, V24, P225, DOI 10.1017/S0954579411000794 Winsler A, 2007, J AUTISM DEV DISORD, V37, P1617, DOI 10.1007/s10803-006-0294-8 Yi K, 2011, J DEAF STUD DEAF EDU, V16, P375, DOI 10.1093/deafed/enq065 NR 72 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 720 EP 730 DI 10.1002/aur.1424 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700009 PM 25346354 ER PT J AU Sasson, NJ Faso, DJ Parlier, M Daniels, JL Piven, J AF Sasson, Noah J. Faso, Daniel J. Parlier, Morgan Daniels, Julie L. Piven, Joseph TI When Father Doesn't Know Best: Selective Disagreement Between Self-Report and Informant Report of the Broad Autism Phenotype in Parents of a Child with Autism SO AUTISM RESEARCH LA English DT Article DE clinical psychiatry; clinical psychology; social cognition; personality assessment; personality traits; informant reports; broad autism phenotype ID INTERGENERATIONAL TRANSMISSION; PERSONALITY PATHOLOGY; PREDICTIVE-VALIDITY; SPECTRUM DISORDER; SOCIAL-COGNITION; INDIVIDUALS; PERSPECTIVE; TRAITS; ACCURACY AB The Broad Autism Phenotype Questionnaire (BAPQ) is a reliable tool for identifying three autism-related traitssocial aloofness, pragmatic language abnormalities and rigid personalitywithin families of a person with autism and the general population. Although little is known concerning agreement between self-report and informant report versions of the BAPQ, identifying individual characteristics affecting agreement between the two can highlight important considerations for maximizing its yield, particularly when only one version is administered. Here, analysis of self-report and informant report of the BAPQ completed by 444 parents of a child with autism revealed moderate to strong agreement between the two versions for all three broad autism phenotype (BAP) traits when the self-reporting parent did not possess the trait being assessed. In contrast, disagreement selectively occurred when the assessed parent was positive for the BAP trait being rated. This pattern was driven primarily by fathers who were positive for a BAP trait endorsing lower levels of that trait relative to informant report. This discrepancy did not occur for mothers, nor did it occur for fathers lacking BAP traits. Because this pattern was specific to fathers positive for BAP traits, it likely reflects selective blind spots in their self-reporting and not poorer self-reporting by fathers more broadly, nor a general tendency of overreporting by informant mothers. The presence of BAP traits in informing parents, however, largely did not reduce agreement between self-report and informant report. In sum, self-report may underestimate the presence of BAP traits in fathers but is generally consistent with informant report for mothers. Autism Res2014, 7: 731-739. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Sasson, Noah J.; Faso, Daniel J.] Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 75080 USA. [Parlier, Morgan; Daniels, Julie L.; Piven, Joseph] Univ N Carolina, Sch Med, Carolina Inst Dev Disabil, Chapel Hill, NC USA. [Daniels, Julie L.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. RP Sasson, NJ (reprint author), Univ Texas Dallas, Sch Behav & Brain Sci, 800 W Campbell Rd,GR41, Richardson, TX 75080 USA. EM nsasson@utdallas.edu FU Research Registry Core of the Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center (IDDRC) at UNC-Chapel Hill [HD003110]; Centers for Disease Control and Prevention [U10 DD000184-06, U50/CCU422345] FX We greatly appreciate the help of Renee Clark and the Research Registry Core of the Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center (IDDRC) at UNC-Chapel Hill (Grant Number HD003110). This work was further supported by the Centers for Disease Control and Prevention (Grant Numbers: U10 DD000184-06, U50/CCU422345). We also would like to thank Dr. Robert Ackerman for his assistance with statistical analysis. Finally, we thank all the parents who participated in this research. The authors report no conflict of interests. CR BAILEY A, 1995, PSYCHOL MED, V25, P63 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x Carlson E., 2010, SOCIAL PERSONALITY P, V4, P605, DOI DOI 10.1111/J.1751-9004.2010.00280.X Carlson EN, 2013, PERSPECT PSYCHOL SCI, V8, P173, DOI 10.1177/1745691612462584 Carlson EN, 2011, J PERS SOC PSYCHOL, V101, P185, DOI 10.1037/a0023781 Carlson EN, 2013, J PERS, V81, P155, DOI 10.1111/j.1467-6494.2012.00794.x Clifton A, 2005, PSYCHOL ASSESSMENT, V17, P123, DOI 10.1037/1040-3590.17.2.123 Connelly BS, 2010, PSYCHOL BULL, V136, P1092, DOI 10.1037/a0021212 Constantino J. N., 2012, SOCIAL RESPONSIVENES, Vsecond Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014 Gonzalez R., 2000, SOCIAL PSYCHOL PERSO, P181 Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3 Ingersoll B, 2011, J AUTISM DEV DISORD, V41, P1646, DOI 10.1007/s10803-011-1192-2 JOHN OP, 1993, J PERS, V61, P521, DOI 10.1111/j.1467-6494.1993.tb00781.x LANDA R, 1992, PSYCHOL MED, V22, P245 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Losh M, 2007, J CHILD PSYCHOL PSYC, V48, P105, DOI 10.1111/j.1469-7610.2006.01594.x Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34 Lyall K, 2014, JAMA PSYCHIAT, V71, P936, DOI 10.1001/jamapsychiatry.2014.476 Mosterman RM, 2011, CLIN PSYCHOL PSYCHOT, V18, P159, DOI 10.1002/cpp.708 Oltmanns T. F., 2006, PERSONALITY PSYCHOPA, P71 Oltmanns TF, 2009, CURR DIR PSYCHOL SCI, V18, P32, DOI 10.1111/j.1467-8721.2009.01601.x Ozonoff S, 2014, J AM ACAD CHILD PSY, V53, P398, DOI 10.1016/j.jaac.2013.12.020 PIVEN J, 1994, PSYCHOL MED, V24, P783 Piven J, 1997, AM J MED GENET, V74, P398, DOI 10.1002/(SICI)1096-8628(19970725)74:4<398::AID-AJMG11>3.0.CO;2-D Sasson NJ, 2013, AUTISM, V17, P655, DOI 10.1177/1362361312455704 Sasson NJ, 2013, AUTISM RES, V6, P134, DOI 10.1002/aur.1272 Sasson NJ, 2013, J NEURODEV DISORD, V5, DOI 10.1186/1866-1955-5-11 Sasson NJ, 2011, J NEURODEV DISORD, V3, P87, DOI 10.1007/s11689-010-9068-x Schriber RA, 2014, J PERS SOC PSYCHOL, V106, P112, DOI 10.1037/a0034950 Vazire S, 2008, J PERS SOC PSYCHOL, V95, P1202, DOI 10.1037/a0013314 ZIMMERMAN M, 1986, J CLIN PSYCHIAT, V47, P261 NR 33 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2014 VL 7 IS 6 BP 731 EP 739 DI 10.1002/aur.1425 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AW7TR UT WOS:000346467700010 PM 25339495 ER PT J AU Barneveld, PS Swaab, H van Engeland, H de Sonneville, L AF Barneveld, Petra Suzanne Swaab, Hanna van Engeland, Herman de Sonneville, Leo TI Cross-Sectional Evidence for a Decrease in Cognitive Function With Age in Children With Autism Spectrum Disorders? SO AUTISM RESEARCH LA English DT Article DE cognitive functioning; intelligence profiles; development; age; autism spectrum disorders ID IQ; PROFILES; CHILDHOOD AB Autism spectrum disorders (ASD) are associated with early disturbances in brain maturation processes and these interferences presumably have their consequences for the progressive emergence of cognitive deficits later in life, as expressed in intelligence profiles. In this study, we addressed the impact of age on cognitive functioning of 6- to 15-year-old children and adolescents with ASD. Intelligence profiles were measured by the Wechsler Intelligence Scale for Children and compared among four consecutive age cohorts (children aged 6.17-8.03 years, 8.04-9.61 years, and 9.68-11.50 years and adolescents aged 11.54-15.85 years) of 237 high-functioning boys with ASD. The results clearly demonstrated that the global intelligence level was lower in children aged 8 years and older, when compared with 6- and 7-year-old children with ASD. This is mostly due to the Freedom From Distractibility factor, suggesting that older children were less able to sustain their attention, they were more distractible, or had more graph motor difficulties. Moreover, an effect of age was also found with respect to the relatively poor performance on the subtest Comprehension when compared with other verbal comprehension subtests, indicating that specifically the impairments in verbal comprehension and social reasoning abilities were more profound in older children when compared with 6- and 7-year-old children with ASD. Findings of this cross-sectional study showed that it is relevant to take age into account when evaluating the impact of cognitive impairments on intelligence in children with ASD, because the impact of these developmental disorders might be different at different ages. Autism Res2014, 7: 527-534. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Barneveld, Petra Suzanne; Swaab, Hanna; de Sonneville, Leo] Leiden Univ, Dept Clin Child & Adolescent Studies, NL-2300 RB Leiden, Netherlands. [Swaab, Hanna; de Sonneville, Leo] Leiden Univ, Leiden Inst Brain & Cognit, NL-2300 RB Leiden, Netherlands. [van Engeland, Herman] Univ Med Ctr Utrecht, Dept Child & Adolescent Psychiat, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands. RP Barneveld, PS (reprint author), Leiden Univ, Fac Social Sci, Dept Clin Child & Adolescent Studies, POB 9555, NL-2300 RB Leiden, Netherlands. EM barneveldps@fsw.leidenuniv.nl CR Achenbach T. M., 1991, INTEGRATIVE GUIDE 19 Achenbach T. M., 1986, MANUAL TEACHER REPOR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Anderson P, 2002, CHILD NEUROPSYCHOL, V8, P71 Anderson V, 2001, DEV NEUROPSYCHOLOGY Anderson VA, 2001, DEV NEUROPSYCHOL, V20, P385, DOI 10.1207/S15326942DN2001_5 ASARNOW RF, 1987, J CHILD PSYCHOL PSYC, V28, P273, DOI 10.1111/j.1469-7610.1987.tb00210.x Calhoun SL, 2005, PSYCHOL SCHOOLS, V42, P333, DOI 10.1002/pits.20067 Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991 Courchesne E, 2005, INT J DEV NEUROSCI, V23, P153, DOI 10.1016/j.ijdevneu.2005.01.003 de Bruin EI, 2006, J ABNORM CHILD PSYCH, V34, P263, DOI 10.1007/s10802-005-9018-3 HAPPE FGE, 1994, J CHILD PSYCHOL PSYC, V35, P1461, DOI 10.1111/j.1469-7610.1994.tb01287.x Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092 Kaufman A. S., 1975, J CONSULT CLIN PSYCH, V52, P74 Kaufman A.S., 1990, ASSESSING ADOLESCENT Lincoln A. J., 1995, LEARNING COGNITION A, P89 LINCOLN AJ, 1988, J AUTISM DEV DISORD, V18, P505, DOI 10.1007/BF02211870 VENTER A, 1992, J CHILD PSYCHOL PSYC, V33, P489, DOI 10.1111/j.1469-7610.1992.tb00887.x Manjiviona J., 1999, AUTISM, V3, P327, DOI DOI 10.1177/1362361399003004003 Mayes S. D., 2004, SIMILARITIES DIFFERE Mayes SD, 2003, J AUTISM DEV DISORD, V33, P329, DOI 10.1023/A:1024462719081 Mayes SD, 2003, AUTISM, V7, P65, DOI 10.1177/1362361303007001006 Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287 Palmen SJMC, 2004, J NEURAL TRANSM, V111, P903, DOI 10.1007/s00702-003-0068-9 Rumsey JM, 1992, HIGH FUNCTIONING IND, P41 SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x Siegel DJ, 1996, J AUTISM DEV DISORD, V26, P389, DOI 10.1007/BF02172825 Stevens J., 1986, APPL MULTIVARIATE ST Walker E, 2002, SCHIZOPHR RES, V54, P17, DOI 10.1016/S0920-9964(01)00347-4 Wechsler D., 1991, MANUAL WECHSLER INTE Wechsler D., 1974, MANUAL WECHSLER INTE NR 31 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 527 EP 534 DI 10.1002/aur.1380 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300001 PM 25132666 ER PT J AU Shandley, K Austin, DW Bhowmik, JL AF Shandley, Kerrie Austin, David W. Bhowmik, Jahar L. TI Are Urinary Porphyrins a Valid Diagnostic Biomarker of Autism Spectrum Disorder? SO AUTISM RESEARCH LA English DT Article DE porphyrins; biomarker; ASD diagnosis; ASD severity; heavy metals; mercury ID OXIDATIVE STRESS; NORMAL-CHILDREN; COPROPORPHYRINOGEN OXIDASE; ENVIRONMENTAL TOXICITY; EXCRETION; MERCURY; PREVALENCE; EXPOSURE; MARKER AB A fundamental challenge to the timely diagnosis of Autism Spectrum Disorder (ASD) is the reliance on the observation of a set of aberrant behavior. Consequently, the diagnostic process requires that the child reach an age where the behaviors would typically be exhibited. The identification of a reliable biological marker (biomarker) could be of considerable benefit to the diagnostic process. As a diagnostic biomarker, porphyrins present an attractive prospect as previous studies have reported consistent findings of children with ASD showing significant elevations in porphyrin levels in contrast to controls. Furthermore, there is some evidence that ASD severity may be associated with porphyrins, which would be a valuable characteristic of any ASD biomarker. Importantly, for practical use, porphyrins can be tested non-invasively via a sample of urine. The present study sought to investigate whether porphyrin profiles can reliably be used to (a) differentiate ASD cases from healthy controls; and (b) predict ASD severity. The study compared the porphyrin levels of three groups of children aged 2-6 years: Group 1children diagnosed with ASD (n=70); Group 2healthy, normally developing siblings of children diagnosed with ASD (n=36); and Group 3healthy, normally developing children with no known blood relative diagnosed with ASD (n=54). The results of logistic regression analyses failed to find support for the hypotheses that porphyrin levels could be used as a valid tool to detect ASD cases or predict severity. Autism Res2014, 7: 535-542. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Shandley, Kerrie; Austin, David W.] Deakin Univ, Fac Hlth, Sch Psychol, Burwood, Vic 3125, Australia. [Bhowmik, Jahar L.] Swinburne Univ Technol, Fac Life & Social Sci, Hawthorn, Vic 3122, Australia. RP Austin, DW (reprint author), Deakin Univ, Fac Hlth, Sch Psychol, 221 Burwood Highway, Burwood, Vic 3125, Australia. EM david.austin@deakin.edu.au CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT Amminger GP, 2007, BIOL PSYCHIAT, V61, P551, DOI 10.1016/j.biopsych.2006.05.007 Austin DW, 2008, J TOXICOL ENV HEAL A, V71, P1349, DOI 10.1080/15287390802271723 Barbaro J, 2010, J DEV BEHAV PEDIATR, V31, P376, DOI 10.1097/DBP.0b013e3181df7f3c BLOOM KE, 1991, AM J KIDNEY DIS, V18, P483 Blumberg S. J., 2013, NATL HLTH STAT REPOR, V65 BREWSTER MA, 1988, ANN CLIN LAB SCI, V18, P306 Deth R, 2008, NEUROTOXICOLOGY, V29, P190, DOI 10.1016/j.neuro.2007.09.010 Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343 Geier DA, 2009, J NEUROL SCI, V280, P101, DOI 10.1016/j.jns.2008.08.021 Geier DA, 2007, J TOXICOL ENV HEAL A, V70, P1723, DOI 10.1080/15287390701457712 Geier DA, 2006, NEUROTOX RES, V10, P57 Herbert MR, 2005, NEUROSCIENTIST, V11, P417, DOI 10.1177/0091270005278866 Heyer NJ, 2006, TOXICOL LETT, V161, P159, DOI 10.1016/j.toxlet.2005.09.005 Heyer NJ, 2012, AUTISM RES, V5, P84, DOI 10.1002/aur.236 HSIA DYY, 1954, P SOC EXP BIOL MED, V85, P86 James SJ, 2004, AM J CLIN NUTR, V80, P1611 Kern JK, 2011, PEDIATR INT, V53, P147, DOI 10.1111/j.1442-200X.2010.03196.x Kern JK, 2006, J TOXICOL ENV HEAL B, V9, P485, DOI 10.1080/10937400600882079 Minder EI, 1996, EUR J CLIN CHEM CLIN, V34, P439 Nataf R, 2006, TOXICOL APPL PHARM, V214, P99, DOI 10.1016/j.taap.2006.04.008 Oliveira G, 2007, DEV MED CHILD NEUROL, V49, P726 Pardo Carlos A, 2005, Int Rev Psychiatry, V17, P485, DOI 10.1080/02646830500381930 Parracho HMRT, 2005, J MED MICROBIOL, V54, P987, DOI 10.1099/jmm.0.46101-0 Rossignol D. A., 2008, AM J BIOCH BIOTECHNO, V4, P208, DOI DOI 10.3844/AJBBSP.2008.208.217 SCHOPLER E, 1980, J AUTISM DEV DISORD, V10, P91, DOI 10.1007/BF02408436 Shandley K, 2011, J TOXICOL ENV HEAL A, V74, P1185, DOI 10.1080/15287394.2011.590097 Synergies Economic Consulting, 2007, EC COSTS AUT SPECTR Synergies Economic Consulting, 2012, EC BEN EARL INT CHIL Vancassel S, 2001, PROSTAG LEUKOTR ESS, V65, P1, DOI 10.1054/plef.2001.0281 Williams K, 2008, J PAEDIATR CHILD H, V44, P504, DOI 10.1111/j.1440-1754.2008.01331.x Woods J. S., 1995, TOXICOLOGY METALS, V115, P19 Woods JS, 2005, TOXICOL APPL PHARM, V206, P113, DOI 10.1016/j.taap.2004.12.016 Woods JS, 2010, ENVIRON HEALTH PERSP, V118, P1450, DOI 10.1289/ehp.0901713 WOODS JS, 1983, BIOCHEM PHARMACOL, V32, P73, DOI 10.1016/0006-2952(83)90655-X Woods JS, 2009, CLIN CHIM ACTA, V405, P104, DOI 10.1016/j.cca.2009.04.014 Youn SI, 2010, J TOXICOL ENV HEAL A, V73, P701, DOI 10.1080/15287391003614000 Zimmerman AW, 2005, PEDIATR NEUROL, V33, P195, DOI 10.1016/j.pediatrneurol.2005.03.014 NR 38 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 535 EP 542 DI 10.1002/aur.1385 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300002 PM 24756868 ER PT J AU Wong, AYS Hsia, YF Chan, EW Murphy, DGM Simonoff, E Buitelaar, JK Wong, ICK AF Wong, Angel Y. S. Hsia, Yingfen Chan, Esther W. Murphy, Declan G. M. Simonoff, Emily Buitelaar, Jan K. Wong, Ian C. K. TI The Variation of Psychopharmacological Prescription Rates for People With Autism Spectrum Disorder (ASD) in 30 Countries SO AUTISM RESEARCH LA English DT Article DE epidemiology; Gross Domestic Product; Psychopharmacology; Multinational study ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PSYCHOTROPIC MEDICATION USE; PSYCHIATRIC-DISORDERS; UNITED-KINGDOM; PRIMARY-CARE; CHILDREN; ADOLESCENTS; PREVALENCE; POPULATION; UK AB There is significant variation in prescriptions among countries in clinical practice for the treatment of comorbidities associated with autism spectrum disorder (ASD). It has been suggested that many people with mental health disorders in low-/middle-income countries do not receive adequate treatment. Hence, this study investigated psychopharmacological treatment patterns for ASD comorbidities in 30 countries and the association between country's income and prescription rates. The IMS Prescribing Insights database was used to investigate prescription patterns for ASD comorbidity treatment from 2007 to 2012. Data were obtained from 30 countries in continents of Europe, Asia, Oceania, Central America, South America, and Africa. The gross domestic product (GDP) per capita was used as a proxy for each country's income. Spearman correlation was used to examine the association between prescription rate and GDP per capita. The highest prescription rates were found in Western Europe (3.89-36.36/10,000) while the lowest prescription rates were found in Asian countries, such as Turkey, Indonesia, Saudi Arabia, and Pakistan (0.04-0.82/10,000). The most commonly prescribed drug for ASD comorbidity treatment in most of the countries was risperidone, but antidepressants and antiepileptic drugs were also frequently prescribed. There was a significant positive correlation between GDP per capita and prescription rate (Spearman =0.60; P=0.0011; 95% confidence interval 0.27-0.81), that is, the higher the GDP per capita, the higher the prescription rate. There are marked international differences in prescription rates, and this is partially accounted by economic factors. Future research should combine more data for ASD comorbidity treatment to explore the disparity of psychopharmacological treatment between countries. Autism Res2014, 7: 543-554. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Wong, Angel Y. S.; Hsia, Yingfen; Chan, Esther W.; Wong, Ian C. K.] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Ctr Safe Medicat Practice & Res, Pokfulam, Hong Kong, Peoples R China. [Murphy, Declan G. M.] Kings Coll London, Inst Psychiat, Sackler Inst Translat Neurodev Res, Dept Forens & Dev Sci, London WC2R 2LS, England. [Simonoff, Emily] Kings Coll London, Dept Child & Adolescent Psychiat, Inst Psychiat, London WC2R 2LS, England. [Simonoff, Emily] Kings Coll London, Biomed Res Ctr Mental Hlth, London WC2R 2LS, England. [Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands. [Hsia, Yingfen; Wong, Ian C. K.] UCL, UCL Sch Pharm, Dept Practice & Policy, Ctr Paediat Pharm Res, London, England. RP Wong, ICK (reprint author), Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Ctr Safe Medicat Practice & Res, Pokfulam, Hong Kong, Peoples R China. EM wongick@hku.hk FU Innovative Medicines Initiative (IMI) Joint Undertaking under European Autism Interventions (EU-AIMS) - European Union [115300]; European Federation of Pharmaceutical Industries and Associations (EFPIA); National Institute of Health Research (UK) FX This research was supported by the Innovative Medicines Initiative (IMI) Joint Undertaking under grant agreement no. 115300: European Autism Interventions (EU-AIMS), which are composed of financial contributions from the European Union's Seventh Framework Programme (FP7/2007-2013), and the European Federation of Pharmaceutical Industries and Associations (EFPIA). D. G. M. M., I. C. K. W and E. S. also received funding from the National Institute of Health Research (UK) for a program grant on this topic and for a neurodevelopmental theme in the Biomedical Research Centre at the Institute of Psychiatry, London, United Kingdom. CR Almandil NB, 2011, ARCH DIS CHILDHOOD-E, V96, P192, DOI [10.1136/archdischild-192 2011-300054, 10.1136/archdischild-2011-300054] Almandil NB, 2013, PEDIATR DRUGS, V15, P139, DOI 10.1007/s40272-013-0016-6 American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Balkrishnan R, 2009, J HUM HYPERTENS, V23, P420, DOI 10.1038/jhh.2008.139 Bradley E, 2006, BRIT J PSYCHIAT, V189, P361, DOI 10.1192/bjp.bp.105.018127 Cadman T, 2012, J AM ACAD CHILD PSY, V51, P879, DOI 10.1016/j.jaac.2012.06.017 Carbone PS, 2010, AM FAM PHYSICIAN, V81, P453 Coury Daniel L, 2012, Pediatrics, V130 Suppl 2, pS69, DOI 10.1542/peds.2012-0900D Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239 European Medicines Agency (EMA), 2007, ASS PAED NEEDS PSYCH Frazier TW, 2011, J CHILD ADOL PSYCHOP, V21, P571, DOI 10.1089/cap.2011.0057 Hollander E, 2003, LANCET, V362, P732, DOI 10.1016/S0140-6736(03)14236-5 Hsia YF, 2014, PSYCHOPHARMACOLOGY, V231, P999, DOI 10.1007/s00213-013-3263-x Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522 Livermore DM, 2006, INT J ANTIMICROB AG, V28, P273, DOI 10.1016/j.ijantimicag.2006.05.025 Lund C, 2012, PLOS MED, V9, DOI 10.1371/journal.pmed.1001359 MacArthur G., 2008, CHALLENGES PRIORITIE MacNeil BM, 2009, RES AUTISM SPECT DIS, V3, P1, DOI 10.1016/j.rasd.2008.06.001 Mandell DS, 2008, PEDIATRICS, V121, pE441, DOI 10.1542/peds.2007-0984 Marcus RN, 2009, J AM ACAD CHILD PSY, V48, P1110, DOI 10.1097/CHI.0b013e3181b76658 Matson JL, 2009, RES AUTISM SPECT DIS, V3, P999, DOI 10.1016/j.rasd.2009.06.003 McPheeters ML, 2011, PEDIATRICS, V127, pE1312, DOI 10.1542/peds.2011-0427 Murray ML, 2014, PSYCHOPHARMACOLOGY, V231, P1011, DOI 10.1007/s00213-013-3140-7 Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362 Owen R, 2009, PEDIATRICS, V124, P1533, DOI 10.1542/peds.2008-3782 Rani F, 2008, PEDIATRICS, V121, P1002, DOI 10.1542/peds.2007-2008 Rani FA, 2011, DRUG SAFETY, V34, P773, DOI 10.2165/11591120-000000000-00000 Rani FA, 2009, DRUG SAFETY, V32, P325, DOI 10.2165/00002018-200932040-00006 Rosenberg RE, 2010, J AUTISM DEV DISORD, V40, P342, DOI 10.1007/s10803-009-0878-1 Saxena Shekhar, 2003, J Ment Health Policy Econ, V6, P135 Shea S, 2004, PEDIATRICS, V114, pE634, DOI 10.1542/peds.2003-0264-F Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f Souders MC, 2009, SLEEP, V32, P1566 Star K, 2012, J CHILD ADOL PSYCHOP, V22, P440, DOI 10.1089/cap.2011.0134 Wang PS, 2007, LANCET, V370, P841, DOI 10.1016/S0140-6736(07)61414-7 Williams JG, 2006, ARCH DIS CHILD, V91, P8, DOI 10.1136/adc.2004.062083 Wong ICK, 2005, BRIT J CLIN PHARMACO, V59, P750, DOI 10.1111/j.1365-2125.2005.02450.x Wong ICK, 2004, ARCH DIS CHILD, V89, P1131, DOI 10.1136/adc.2004.050468 World Health Organisation, 2012, ICD 10 CLASS MENT BE World Health Organization (WHO), 2013, APPL INCL 19 EXP COM Zito J. M., 2008, CHILD ADOL PSYCH CL, V2, P1 NR 42 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 543 EP 554 DI 10.1002/aur.1391 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300003 PM 24895332 ER PT J AU Amodeo, DA Jones, JH Sweeney, JA Ragozzino, ME AF Amodeo, Dionisio A. Jones, Joshua H. Sweeney, John A. Ragozzino, Michael E. TI Risperidone and the 5-HT2(A) Receptor Antagonist M100907 Improve Probabilistic Reversal Learning in BTBR T plus tf/J Mice SO AUTISM RESEARCH LA English DT Article DE autism; cognitive flexibility; BTBR; reversal learning; serotonin; risperidone ID AUTISM SPECTRUM DISORDERS; PERVASIVE DEVELOPMENTAL DISORDERS; INBRED MOUSE STRAINS; REPETITIVE BEHAVIOR; DORSOMEDIAL STRIATUM; ATTENTIONAL SET; DOUBLE-BLIND; ATYPICAL ANTIPSYCHOTICS; ORBITOFRONTAL CORTEX; MENTAL-RETARDATION AB Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions with restricted interests and repetitive behaviors (RRBs). RRBs can severely limit daily living and be particularly stressful to family members. To date, there are limited options for treating this feature in ASD. Risperidone, an atypical antipsychotic, is approved to treat irritability in ASD, but less is known about whether it is effective in treating higher order RRBs, for example cognitive inflexibility. Risperidone also has multiple receptor targets in which only a subset may be procognitive and others induce cognitive impairment. 5HT(2A) receptor blockade represents one promising and more targeted approach, as various preclinical studies have shown that 5HT(2A) receptor antagonists improve cognition. The present study investigated whether risperidone and/or M100907, a 5HT(2A) receptor antagonist, improved probabilistic reversal learning performance in the BTBR T+tf/J (BTBR) mouse model of autism. The effects of these treatments were also investigated in C57BL/6J (B6) mice as a comparison strain. Using a spatial reversal learning test with 80/20 probabilistic feedback, similar to one in which ASD individuals exhibit impairments, both risperidone (0.125mg) and M100907 (0.01 and 0.1mg) improved reversal learning in BTBR mice. Risperidone (0.125mg) impaired reversal learning in B6 mice. Improvement in probabilistic reversal learning performance resulted from treatments enhancing the maintenance of the newly correct choice pattern. Because risperidone can lead to unwanted side effects, treatment with a specific 5HT(2A) receptor antagonist may improve cognitive flexibility in individuals with ASD while also minimizing unwanted side effects. Autism Res2014, 7: 555-567. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Amodeo, Dionisio A.; Jones, Joshua H.; Ragozzino, Michael E.] Univ Illinois, Dept Psychol, Chicago, IL 60607 USA. [Sweeney, John A.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. RP Ragozzino, ME (reprint author), Univ Illinois, Dept Psychol, 1007 West Harrison St, Chicago, IL 60607 USA. EM mrago@uic.edu FU NIH [P50 HD055751] FX Grant sponsor: NIH Grant Number: P50 HD055751 CR Aguilar MA, 1997, BEHAV PHARMACOL, V8, P669, DOI 10.1097/00008877-199712000-00001 Aman MG, 2002, AM J PSYCHIAT, V159, P1337, DOI 10.1176/appi.ajp.159.8.1337 Amodeo DA, 2012, BEHAV BRAIN RES, V227, P64, DOI 10.1016/j.bbr.2011.10.032 Baker PM, 2011, BEHAV BRAIN RES, V219, P123, DOI 10.1016/j.bbr.2010.12.031 Bishop SL, 2007, AM J MENT RETARD, V112, P450, DOI 10.1352/0895-8017(2007)112[450:POPNII]2.0.CO;2 Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855 Brown HD, 2012, J PSYCHOPHARMACOL, V26, P1443, DOI 10.1177/0269881111430749 Canitano R, 2011, PROG NEURO-PSYCHOPH, V35, P18, DOI 10.1016/j.pnpbp.2010.10.015 Chadman KK, 2011, PHARMACOL BIOCHEM BE, V97, P586, DOI 10.1016/j.pbb.2010.09.012 Cho IH, 2007, BRAIN RES, V1139, P34, DOI 10.1016/j.brainres.2007.01.002 Chudasama Y, 2003, J NEUROSCI, V23, P8771 Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008 Coutinho AM, 2004, MOL PSYCHIATR, V9, P264, DOI 10.1038/sj.mp.4001409 D'Cruz AM, 2013, NEUROPSYCHOLOGY, V27, P152, DOI 10.1037/a0031721 Desteno DA, 2009, NEUROSCIENCE, V162, P118, DOI 10.1016/j.neuroscience.2009.04.052 Dias R, 1997, J NEUROSCI, V17, P9285 Dove D, 2012, PEDIATRICS, V130, P717, DOI 10.1542/peds.2012-0683 Findling RL, 2000, J AM ACAD CHILD PSY, V39, P509, DOI 10.1097/00004583-200004000-00021 Floresco SB, 2006, NEUROPSYCHOPHARMACOL, V31, P297, DOI 10.1038/sj.npp.1300825 Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203 Furr A, 2012, INT J NEUROPSYCHOPH, V15, P1295, DOI 10.1017/S1461145711001441 Gabriele S, 2014, EUR NEUROPSYCHOPHARM, V24, P919, DOI 10.1016/j.euroneuro.2014.02.004 Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006 Goldman S, 2009, DEV MED CHILD NEUROL, V51, P30, DOI 10.1111/j.1469-8749.2008.03178.x Gould GG, 2011, J NEUROCHEM, V116, P291, DOI 10.1111/j.1471-4159.2010.07104.x Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627 Hollander E, 2012, AM J PSYCHIAT, V169, P292, DOI 10.1176/appi.ajp.2011.10050764 HUGHES C, 1994, NEUROPSYCHOLOGIA, V32, P477, DOI 10.1016/0028-3932(94)90092-2 Kaland N, 2007, AUTISM, V11, P81, DOI 10.1177/1362361307070988 Kim J, 2005, NEUROBIOL LEARN MEM, V83, P125, DOI 10.1016/j.nlm.2004.10.003 Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z Lindgren HS, 2013, NEUROPHARMACOLOGY, V71, P148, DOI 10.1016/j.neuropharm.2013.03.034 Marek GJ, 2005, NEUROPSYCHOPHARMACOL, V30, P2205, DOI 10.1038/sj.npp.1300762 McCool MF, 2008, NEUROBIOL LEARN MEM, V89, P114, DOI 10.1016/j.nlm.2007.06.005 McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142 McDougle CJ, 2000, J AUTISM DEV DISORD, V30, P427, DOI 10.1023/A:1005551523657 McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x McPheeters M. L., 2011, PEDIATRICS, V127, P1312 Mehta MA, 1999, PSYCHOPHARMACOLOGY, V146, P162, DOI 10.1007/s002130051102 Mehta MA, 2004, PSYCHOPHARMACOLOGY, V176, P331, DOI 10.1007/s00213-004-1899-2 Memari AH, 2013, RES DEV DISABIL, V34, P3218, DOI 10.1016/j.ridd.2013.06.033 Moy SS, 2008, BEHAV BRAIN RES, V191, P118, DOI 10.1016/j.bbr.2008.03.015 Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0 Owley T, 2005, J AM ACAD CHILD PSY, V44, P343, DOI 10.1097/01.chi.0000153229.80215.a0 OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110 Palencia CA, 2006, NEUROSCIENCE, V143, P671, DOI 10.1016/j.neuroscience.2006.08.024 Pearson B. L., 2011, GENES BRAIN BEHAV, V216, P228 Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040 Pobbe RLH, 2010, BEHAV BRAIN RES, V214, P443, DOI 10.1016/j.bbr.2010.06.025 Politte LC, 2014, PSYCHOPHARMACOLOGY, V231, P1023, DOI 10.1007/s00213-013-3068-y Pooragha F, 2013, IRAN J PEDIATR, V23, P309 Quesseveur G, 2013, EXP BRAIN RES, V226, P285, DOI 10.1007/s00221-013-3434-3 Ragozzino ME, 2004, LEARN MEMORY, V11, P70, DOI 10.1101/lm.65404 Ragozzino ME, 2002, BEHAV NEUROSCI, V116, P105, DOI 10.1037//0735-7044.116.1.105 Rapin I, 2008, PEDIATR CLIN N AM, V55, P1129, DOI 10.1016/j.pcl.2008.07.005 McCracken JT, 2002, NEW ENGL J MED, V347, P314, DOI 10.1056/NEJMoa013171 Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007 Rosenbaum J. F. A. G., 2005, HDB PSYCHIAT DRUG TH Rummel-Kluge C, 2010, SCHIZOPHR RES, V123, P225, DOI 10.1016/j.schres.2010.07.012 Schotte A, 1996, PSYCHOPHARMACOLOGY, V124, P57, DOI 10.1007/BF02245606 Scott Lesley J, 2007, Paediatr Drugs, V9, P343 Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201 Solomon M, 2011, AUTISM RES, V4, P109, DOI 10.1002/aur.177 Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648 Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x Tait DS, 2008, BEHAV BRAIN RES, V187, P100, DOI 10.1016/j.bbr.2007.08.035 Tait DS, 2007, EUR J NEUROSCI, V25, P3719, DOI 10.1111/j.1460-9568.2007.05612.x Talvik-Lotfi M, 2000, PSYCHOPHARMACOLOGY, V148, P400, DOI 10.1007/s002130050069 Tandon R, 2002, PSYCHIAT QUART, V73, P297, DOI 10.1023/A:1020464017021 Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278 Racht-Delatour BV, 1999, NEUROBIOL LEARN MEM, V72, P47 Veenstra-VanderWeele J, 2002, AM J MED GENET, V114, P277, DOI 10.1002/ajmg.10192 Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109 Vollenweider FX, 1998, NEUROREPORT, V9, P3897, DOI 10.1097/00001756-199812010-00024 Williams D, 2013, AUTISM RES, V6, P461, DOI 10.1002/aur.1311 Yang M, 2007, FRONT BEHAV NEUROSCI, V1, DOI [10.3389/neuro.08.001.2007, 10.3389/neuro.08/001.2007] NR 78 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 555 EP 567 DI 10.1002/aur.1395 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300004 PM 24894823 ER PT J AU Wilson, CE Happe, F Wheelwright, SJ Ecker, C Lombardo, MV Johnston, P Daly, E Murphy, CM Spain, D Lai, MC Chakrabarti, B Sauter, DA Baron-Cohen, S Murphy, DGM AF Wilson, C. Ellie Happe, Francesca Wheelwright, Sally J. Ecker, Christine Lombardo, Michael V. Johnston, Patrick Daly, Eileen Murphy, Clodagh M. Spain, Debbie Lai, Meng-Chuan Chakrabarti, Bhismadev Sauter, Disa A. Baron-Cohen, Simon Murphy, Declan G. M. CA MRC AIMS Consortium TI The Neuropsychology of Male Adults With High-Functioning Autism or Asperger Syndrome SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; cognitive profiles; autistic symptomatology; comorbid psychopathology; support vector machine classification; autistic subtypes ID COMPLEX EMOTION RECOGNITION; SPECTRUM QUOTIENT AQ; INDIVIDUAL-DIFFERENCES; EXECUTIVE DYSFUNCTION; EMPATHY QUOTIENT; ANIMATED SHAPES; REVISED VERSION; MENTAL STATES; YOUNG-ADULTS; DISORDER AB Autism Spectrum Disorder (ASD) is diagnosed on the basis of behavioral symptoms, but cognitive abilities may also be useful in characterizing individuals with ASD. One hundred seventy-eight high-functioning male adults, half with ASD and half without, completed tasks assessing IQ, a broad range of cognitive skills, and autistic and comorbid symptomatology. The aims of the study were, first, to determine whether significant differences existed between cases and controls on cognitive tasks, and whether cognitive profiles, derived using a multivariate classification method with data from multiple cognitive tasks, could distinguish between the two groups. Second, to establish whether cognitive skill level was correlated with degree of autistic symptom severity, and third, whether cognitive skill level was correlated with degree of comorbid psychopathology. Fourth, cognitive characteristics of individuals with Asperger Syndrome (AS) and high-functioning autism (HFA) were compared. After controlling for IQ, ASD and control groups scored significantly differently on tasks of social cognition, motor performance, and executive function (P's<0.05). To investigate cognitive profiles, 12 variables were entered into a support vector machine (SVM), which achieved good classification accuracy (81%) at a level significantly better than chance (P<0.0001). After correcting for multiple correlations, there were no significant associations between cognitive performance and severity of either autistic or comorbid symptomatology. There were no significant differences between AS and HFA groups on the cognitive tasks. Cognitive classification models could be a useful aid to the diagnostic process when used in conjunction with other data sourcesincluding clinical history. Autism Res2014, 7: 568-581. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Wilson, C. Ellie; Happe, Francesca; Ecker, Christine; Johnston, Patrick; Daly, Eileen; Murphy, Clodagh M.; Spain, Debbie; Murphy, Declan G. M.] Kings Coll London, Inst Psychiat, Sackler Inst Translat Neurodev, London SE5 8AF, England. [Wheelwright, Sally J.; Lombardo, Michael V.; Lai, Meng-Chuan; Chakrabarti, Bhismadev; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England. [Wheelwright, Sally J.] Univ Southampton, Southampton, Hants, England. [Lombardo, Michael V.] Univ Cyprus, Dept Psychol, Nicosia, Cyprus. [Lombardo, Michael V.] Univ Cyprus, Ctr Appl Neurosci, Nicosia, Cyprus. [Lai, Meng-Chuan] Natl Taiwan Univ, Coll Med, Dept Psychiat, Taipei 10764, Taiwan. [Chakrabarti, Bhismadev] Univ Reading, Sch Psychol & Clin Language Sci, Reading RG6 2AH, Berks, England. [Sauter, Disa A.] Univ Amsterdam, Dept Social Psychol, Amsterdam, Netherlands. [MRC AIMS Consortium] Univ Oxford, Autism Res Grp, Oxford, England. RP Wilson, CE (reprint author), Kings Coll London, Inst Psychiat, Denmark Hill, London SE5 8AF, England. EM ellie.wilson@kcl.ac.uk RI Ecker, Christine/E-5194-2010; Bailey, Anthony/J-2860-2014 OI Bailey, Anthony/0000-0003-4257-972X FU Medical Research Council; AIMS Consortium through Medical Research Council [G0400061]; NIHR Biomedical Research Centre for Mental Health at King's College London, Institute of Psychiatry; South London & Maudsley NHS Foundation Trust; European Union [115300]; EFPIA companies FX The MRC AIMS Consortium is funded by the Medical Research Council and headed by the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry. This work was supported by the AIMS Consortium through grant G0400061 from the Medical Research Council and by the NIHR Biomedical Research Centre for Mental Health at King's College London, Institute of Psychiatry, and South London & Maudsley NHS Foundation Trust. The research leading to these results also received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no 115300, resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies' in kind contribution. The authors would also like to thank all the participants involved in the study. CR Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9 Abramowitz JS, 2006, J ANXIETY DISORD, V20, P1016, DOI 10.1016/j.janxdis.2006.03.001 Adams NC, 2012, J AUTISM DEV DISORD, V42, P1052, DOI 10.1007/s10803-011-1345-3 Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289 Airaksinen E, 2004, PSYCHOL MED, V34, P83, DOI 10.1017/S0033291703008559 Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436 Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00 Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643 BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 Beck A. T., 1990, MANUAL BECK ANXIETY Beck A.T., 1996, MANUAL BECK DEPRESSI Bonnel A, 2010, NEUROPSYCHOLOGIA, V48, P2465, DOI 10.1016/j.neuropsychologia.2010.04.020 BOUCHER J, 1988, J AUTISM DEV DISORD, V18, P637, DOI 10.1007/BF02211881 Brock J, 2011, J CHILD PSYCHOL PSYC, V52, P645, DOI 10.1111/j.1469-7610.2011.02414.x Brunsdon VEA, 2014, AUTISM, V18, P17, DOI 10.1177/1362361313499456 Burges CJC, 1998, DATA MIN KNOWL DISC, V2, P121, DOI 10.1023/A:1009715923555 Castaneda AE, 2008, J AFFECT DISORDERS, V106, P1, DOI 10.1016/j.jad.2007.06.006 Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189 Cavallaro R, 2003, BIOL PSYCHIAT, V54, P437, DOI 10.1016/S0002-3223(03)01814-0 Chakrabarti B, 2009, AUTISM RES, V2, P157, DOI 10.1002/aur.80 Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075 Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010 Fossati P, 1999, PSYCHIAT RES, V89, P171, DOI 10.1016/S0165-1781(99)00110-9 Frith U., 1989, AUTISM EXPLAINING EN Gathercole S E, 1994, Memory, V2, P103, DOI 10.1080/09658219408258940 Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5 Golan O, 2006, J AUTISM DEV DISORD, V36, P169, DOI 10.1007/s10803-005-0057-y Goldenfeld N., 2006, CLIN NEUROPSYCHIATRY, V2, P338 Green D. M., 1966, SIGNAL DETECTION THE Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093 Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003 Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Lai MC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020835 Lai MC, 2012, NEUROIMAGE, V61, P1347, DOI 10.1016/j.neuroimage.2012.03.018 Lai MC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047198 Lombardo MV, 2010, WIRES COGN SCI, V1, P393, DOI 10.1002/wcs.45 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Low J, 2009, BRIT J DEV PSYCHOL, V27, P425, DOI 10.1348/026151008X334728 Lundqvist D., 1998, KAROLINSKA DIRECTED Macintosh KE, 2004, J CHILD PSYCHOL PSYC, V45, P421, DOI 10.1111/j.1469-7610.2004.00234.x Marazziti D, 2010, EUR J PHARMACOL, V626, P83, DOI 10.1016/j.ejphar.2009.08.046 Noterdaeme M, 2010, EUR CHILD ADOLES PSY, V19, P475, DOI 10.1007/s00787-009-0057-0 OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x Rubia K, 2001, NEUROIMAGE, V13, P250, DOI 10.1006/nimg.2000.0685 RUMSEY JM, 1988, J CLIN EXP NEUROPSYC, V10, P201, DOI 10.1080/01688638808408236 Russell AJ, 2005, BRIT J PSYCHIAT, V186, P525, DOI 10.1192/bjp.186.6.525 Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7 Sachse M, 2013, J AUTISM DEV DISORD, V43, P1222, DOI 10.1007/s10803-012-1668-8 Sahyoun CP, 2009, J AUTISM DEV DISORD, V39, P1014, DOI 10.1007/s10803-009-0712-9 Scheeren AM, 2013, AUTISM RES, V6, P362, DOI 10.1002/aur.1299 Schoelkopf B, 2002, LEARNING KERNELS SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x Skovlund E, 2001, J CLIN EPIDEMIOL, V54, P86, DOI 10.1016/S0895-4356(00)00264-X Smith DJ, 2006, BIPOLAR DISORD, V8, P40, DOI 10.1111/j.1399-5618.2006.00275.x Spek A, 2009, NEUROPSYCHOLOGIA, V47, P652, DOI 10.1016/j.neuropsychologia.2008.11.015 Sucksmith E, 2013, NEUROPSYCHOLOGIA, V51, P98, DOI 10.1016/j.neuropsychologia.2012.11.013 Tiffin J, 1948, J APPL PSYCHOL, V32, P234, DOI 10.1037/h0061266 Uljarevic M, 2013, J AUTISM DEV DISORD, V43, P1517, DOI 10.1007/s10803-012-1695-5 Vapnik V., 1995, NATURE STAT LEARNING Wallace GL, 2011, J AUTISM DEV DISORD, V41, P1475, DOI 10.1007/s10803-010-1170-0 Wechsler D, 1999, WECHSLER ABBREVIATED Wheelwright S, 2006, BRAIN RES, V1079, P47, DOI 10.1016/j.brainres.2006.01.012 White SJ, 2013, J AUTISM DEV DISORD, V43, P114, DOI 10.1007/s10803-012-1550-8 White SJ, 2011, J AUTISM DEV DISORD, V41, P1565, DOI 10.1007/s10803-011-1182-4 Witkin HA, 1971, MANUAL EMBEDDED FIGU Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2 Joshi G, 2013, J AUTISM DEV DISORD, V43, P1314, DOI 10.1007/s10803-012-1679-5 NR 73 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 568 EP 581 DI 10.1002/aur.1394 PG 14 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300005 PM 24903974 ER PT J AU Slaughter, V Sen Ong, S AF Slaughter, Virginia Sen Ong, Su TI Social Behaviors Increase More When Children With ASD Are Imitated by Their Mother vs. an Unfamiliar Adult SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; imitation; mother-child interaction; intervention; social responsiveness ID AUTISTIC-CHILDREN; MIMICRY AB Previous research suggests that being imitated by an adult increases the social behaviors of children with an autism spectrum disorder (ASD). In the current study, we examined whether familiarity with the imitating social partner modulates this effect. Ten children with ASD and their mothers participated. The children's social behaviors were observed prior to and following a 3-min period in which an adult social partner imitated everything they did. In one condition the partner was the child's mother, and in the other condition the partner was an unfamiliar experimenter. The results revealed significant increases in distal social behaviors (gazes toward the adult, vocalizing) following imitation by both partners. There was a significantly greater increase in proximal social behaviors (including approach, being physically close, and touching) and a greater decrease in playing alone when the imitator was the child's mother as opposed to the experimenter. The findings suggest that the experience of being imitated creates an atmosphere of mutuality and rapport between children with ASD and their social partners, which increases their sociability even in interactions with already familiar adults. Autism Res2014, 7: 582-589. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Slaughter, Virginia; Sen Ong, Su] Univ Queensland, Sch Psychol, Early Cognit Dev Ctr, Brisbane, Qld 4072, Australia. RP Slaughter, V (reprint author), Univ Queensland, Sch Psychol, Mc Elwain Bldg, Brisbane, Qld 4072, Australia. EM vps@psy.uq.edu.au CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Carpenter M, 2013, CHILD DEV, V84, P1511, DOI 10.1111/cdev.12083 DAWSON G, 1984, J ABNORM CHILD PSYCH, V12, P209, DOI 10.1007/BF00910664 DAWSON G, 1990, J ABNORM CHILD PSYCH, V18, P335, DOI 10.1007/BF00916569 Dawson G., 1990, DEV PSYCHOPATHOL, V2, P151, DOI 10.1017/S0954579400000675 Dunn L. M., 1997, PPVT 3 PEABODY PICTU Dvortcsak A., 2010, TEACHING SOCIAL COMM Escalona A, 2002, J AUTISM DEV DISORD, V32, P141, DOI 10.1023/A:1014896707002 Fenson L, 2000, APPL PSYCHOLINGUIST, V21, P95 Field T., 2011, AUTISM SPECTRUM DISO, DOI [10.5772/20731, DOI 10.5772/20731] Field T, 2001, AUTISM, V5, P317, DOI 10.1177/1362361301005003008 Greenspan SI, 2006, ENGAGING AUTISM USIN Heimann M, 2006, INFANT CHILD DEV, V15, P297, DOI 10.1002/icd.463 Kasari C, 2010, J AUTISM DEV DISORD, V40, P1045, DOI 10.1007/s10803-010-0955-5 Krug D. A., 1978, ABCAUTISM BEHAV CHEC Lakin JL, 2003, PSYCHOL SCI, V14, P334, DOI 10.1111/1467-9280.14481 Lakin JL, 2003, J NONVERBAL BEHAV, V27, P145, DOI 10.1023/A:1025389814290 Meltzoff AN, 1999, IMITATION INFANCY, P9 Nadel J., 2000, AUTISM, V4, P133, DOI DOI 10.1177/1362361300004002003 Sanefuji W, 2009, INFANT MENT HEALTH J, V30, P145, DOI 10.1002/imhj.20208 Sanefuji W, 2011, INFANT MENT HEALTH J, V32, P134, DOI 10.1002/imhj.20287 Schopler E., 1988, CARS CHILDHOOD AUTIS Stel M, 2010, BRIT J PSYCHOL, V101, P311, DOI 10.1348/000712609X465424 TODA S, 1993, DEV PSYCHOL, V29, P532, DOI 10.1037//0012-1649.29.3.532 NR 24 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 582 EP 589 DI 10.1002/aur.1392 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300006 PM 24903832 ER PT J AU Akechi, H Stein, T Senju, A Kikuchi, Y Tojo, Y Osanai, H Hasegawa, T AF Akechi, Hironori Stein, Timo Senju, Atsushi Kikuchi, Yukiko Tojo, Yoshikuni Osanai, Hiroo Hasegawa, Toshikazu TI Absence of Preferential Unconscious Processing of Eye Contact in Adolescents With Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE eye contact; gaze processing; autism spectrum disorder; unconscious processing ID CONTINUOUS FLASH SUPPRESSION; INTEROCULAR SUPPRESSION; FUNCTIONAL CONNECTIVITY; BINOCULAR-RIVALRY; GAZE DIRECTION; CHILDREN; AMYGDALA; FACES; RESPONSES; PERCEPTION AB Eye contact plays an essential role in social interaction. Atypical eye contact is a diagnostic and widely reported feature of autism spectrum disorder (ASD). Here, we determined whether altered unconscious visual processing of eye contact might underlie atypical eye contact in ASD. Using continuous flash suppression (CFS), we found that typically developing (TD) adolescents detected faces with a direct gaze faster than faces with an averted gaze, indicating enhanced unconscious processing of eye contact. Critically, adolescents with ASD did not show different durations of perceptual suppression for faces with direct and averted gaze, suggesting that preferential unconscious processing of eye contact is absent in this group. In contrast, in a non-CFS control experiment, both adolescents with ASD and TD adolescents detected faces with a direct gaze faster than those with an averted gaze. Another CFS experiment confirmed that unconscious processing of non-social stimuli is intact for adolescents with ASD. These results suggest that atypical processing of eye contact in individuals with ASD could be related to a weaker initial, unconscious registration of eye contact. Autism Res2014, 7: 590-597. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Akechi, Hironori; Kikuchi, Yukiko] Japan Soc Promot Sci, Tokyo, Japan. [Akechi, Hironori] Tokyo Denki Univ, Div Informat Syst Design, Saitama, Japan. [Stein, Timo] Univ Trento, Ctr Mind Brain Sci CIMeC, Trento, Italy. [Senju, Atsushi] Birkbeck Univ London, Ctr Brain & Cognit Dev, London, England. [Kikuchi, Yukiko; Tojo, Yoshikuni] Ibaraki Univ, Coll Educ, Ibaraki, Japan. [Osanai, Hiroo] Musashino Higashi Gakuen, Musashino Higashi Ctr Educ & Res, Tokyo, Japan. [Hasegawa, Toshikazu] Univ Tokyo, Dept Cognit & Behav Sci, Tokyo 1538902, Japan. RP Akechi, H (reprint author), Univ Tampere, Sch Social Sci & Humanities, Tampere 33014, Finland. EM akechi@cogn.jp FU Japan Society for the Promotion of Science (JSPS) [2310946, 2310196]; JSPS [24330207]; UK Medical Research Council [1100252]; Center for Evolutionary Cognitive Sciences at University of Tokyo FX Grant sponsors: Japan Society for the Promotion of Science (JSPS): Grant-in-Aid for JSPS Fellows #2310946 (H. A.) and #2310196 (Y.K.), JSPS: Grant-in-Aid for Scientific Research (B) #24330207 (T. H.), UK Medical Research Council Career Development Award (G) #1100252 (A. S.), and Center for Evolutionary Cognitive Sciences at University of Tokyo. CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th American Psychiatric Association, 2013, DIAGN STAT MAN MENT Clifford S, 2007, J AUTISM DEV DISORD, V37, P301, DOI 10.1007/s10803-006-0160-8 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Farroni T, 2002, P NATL ACAD SCI USA, V99, P9602, DOI 10.1073/pnas.152159999 Grice SJ, 2005, CORTEX, V41, P342, DOI 10.1016/S0010-9452(08)70271-5 Hadjikhani N, 2007, HUM BRAIN MAPP, V28, P441, DOI 10.1002/hbm.20283 Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025 Japanese WISC-III Publication Committee, 1998, NIH WISC 3 CHIN KENS Jiang Y, 2006, CURR BIOL, V16, P2023, DOI 10.1016/j.cub.2006.08.084 Jiang Y, 2007, PSYCHOL SCI, V18, P349, DOI 10.1111/j.1467-9280.2007.01902.x Johnson MH, 2005, NAT REV NEUROSCI, V6, P766, DOI 10.1038/nrn1766 Kikuchi Y, 2011, J AUTISM DEV DISORD, V41, P629, DOI 10.1007/s10803-010-1082-z Kleinhans NM, 2011, NEUROIMAGE, V54, P697, DOI 10.1016/j.neuroimage.2010.07.037 Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334 Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Morris JS, 1998, NATURE, V393, P467, DOI 10.1038/30976 Nummenmaa L, 2009, TRENDS COGN SCI, V13, P135, DOI 10.1016/j.tics.2008.12.006 Pasley BN, 2004, NEURON, V42, P163, DOI 10.1016/S0896-6273(04)00155-2 Pellicano E, 2009, PSYCHON B REV, V16, P1094, DOI 10.3758/PBR.16.6.1094 Rutter M., 2003, AUTISM DIAGNOSTIC IN Rutter M., 2003, SOCIAL COMMUNICATION Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001 Senju A, 2008, BRAIN COGNITION, V67, P127, DOI 10.1016/j.bandc.2007.12.001 Senju A, 2005, NEUROPSYCHOLOGIA, V43, P1297, DOI 10.1016/j.neuropsychologia.2004.12.002 Senju A, 2003, COGNITION, V89, pB43, DOI 10.1016/S0010-0277(03)00081-7 Senju A, 2005, VIS COGN, V12, P1474, DOI 10.1080/13506280444000797 Senju A, 2009, TRENDS COGN SCI, V13, P127, DOI 10.1016/j.tics.2008.11.009 Senju A, 2005, VIS COGN, V12, P127, DOI 10.1080/13506280444000157 Shinagawa F., 1990, JAPANESE WECHSLER AD Stein T, 2011, COGNITION, V119, P307, DOI 10.1016/j.cognition.2011.01.008 Stein T, 2012, COGNITION, V125, P64, DOI 10.1016/j.cognition.2012.06.005 Swartz JR, 2013, J AM ACAD CHILD PSY, V52, P84, DOI 10.1016/j.jaac.2012.10.012 Troiani V., 2012, SOC COGN AFFECT NEUR, V9, P133, DOI [10.1093/scan/nss116, DOI 10.1093/SCAN/NSS116] Troiani V, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00241 Tsuchiya N, 2005, NAT NEUROSCI, V8, P1096, DOI 10.1038/nn1500 Tsuchiya N, 2006, J VISION, V6, P1068, DOI 10.1167/6.10.6 von dem Hagen EAH, 2014, CEREB CORTEX, V24, P1485, DOI 10.1093/cercor/bht003 vonGrunau M, 1995, PERCEPTION, V24, P1297 Wechsler D., 1992, WECHSLER INTELLIGENC Wechsler D, 1981, WECHSLER ADULT INTEL Werner E, 2005, J AUTISM DEV DISORD, V35, P337, DOI 10.1007/s10803-005-3301-6 Williams MA, 2004, J NEUROSCI, V24, P2898, DOI 10.1523/JNEUROSCI.4977-03.2004 Yokoyama T, 2013, NEUROPSYCHOLOGIA, V51, P1161, DOI 10.1016/j.neuropsychologia.2013.04.002 Zaki SR, 2013, AUTISM RES, V6, P280, DOI 10.1002/aur.1292 Zhou W, 2010, CURR BIOL, V20, P1356, DOI 10.1016/j.cub.2010.05.059 Zurcher NR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054313 NR 49 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 590 EP 597 DI 10.1002/aur.1397 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300007 PM 24962761 ER PT J AU Rudra, A Banerjee, S Singhal, N Barua, M Mukerji, S Chakrabarti, B AF Rudra, Alokananda Banerjee, Saoni Singhal, Nidhi Barua, Merry Mukerji, Shaneel Chakrabarti, Bhismadev TI Translation and Usability of Autism Screening and Diagnostic Tools for Autism Spectrum Conditions in India SO AUTISM RESEARCH LA English DT Article DE screening; global mental health; translation; cultural ID PERVASIVE DEVELOPMENTAL DISORDERS; CHILDHOOD AUTISM; CUMULATIVE INCIDENCE; GENERAL-POPULATION; YOUNG-CHILDREN; VALIDITY; PREVALENCE; CHECKLIST; JAPAN; QUESTIONNAIRE AB There is a critical need for screening and diagnostic tools (SDT) for autism spectrum conditions (ASC) in regional languages in South Asia. To address this, we translated four widely used SDT (Social Communication Disorder Checklist, Autism Spectrum Quotient, Social Communication Questionnaire, and Autism Diagnostic Observation Schedule) into Bengali and Hindi, two main regional languages (approximate to 360 million speakers), and tested their usability in children with and without ASC. We found a significant difference in scores between children with ASC (n=45 in Bengali, n=40 in Hindi) and typically developing children (n=43 in Bengali, n=42 in Hindi) on all SDTs. These results demonstrate that these SDTs are usable in South Asia, and constitute an important resource for epidemiology research and clinical diagnosis in the region. Autism Res2014, 7: 598-607. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Rudra, Alokananda; Chakrabarti, Bhismadev] Univ Reading, Sch Psychol & Clin Language Sci, Reading RG6 6AL, Berks, England. [Banerjee, Saoni; Mukerji, Shaneel] Creating Connect, Kolkata, India. [Singhal, Nidhi; Barua, Merry] Act Autism, Natl Ctr Autism, Delhi, India. [Chakrabarti, Bhismadev] Univ Cambridge, Autism Res Ctr, Cambridge, England. RP Chakrabarti, B (reprint author), Univ Reading, Sch Psychol & Clin Language Sci, Reading RG6 6AL, Berks, England. EM b.chakrabarti@reading.ac.uk FU Autism Speaks FX Grant sponsor: Autism Speaks. CR Allen CW, 2007, J AUTISM DEV DISORD, V37, P1272, DOI 10.1007/s10803-006-0279-7 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007 BARONCOHEN S, 1996, BRIT J PSYCHIAT, V168, P158, DOI DOI 10.1192/BJP.168.2.158 Baron-Cohen S, 2000, J ROY SOC MED, V93, P521 Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444 Bolte S, 2004, Z KINDER JUG-PSYCH, V32, P45, DOI 10.1024/1422-4917.32.1.45 Canal-Bedia R, 2011, J AUTISM DEV DISORD, V41, P1342, DOI 10.1007/s10803-010-1163-z Charman T, 2013, CHILD ADOL MENT H-UK, V18, P52, DOI 10.1111/j.1475-3588.2012.00664.x Chojnicka I., 2011, PSYCHIAT POLSKA, V46, P781 Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x Daley TC, 2002, J AUTISM DEV DISORD, V32, P13, DOI 10.1023/A:1017947922349 Eikeseth S, 2009, RES DEV DISABIL, V30, P158, DOI 10.1016/j.ridd.2008.02.003 Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239 Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493 Gadow K, 1994, CHILD SYMPTOM INVENT Ghanizadeh A, 2008, J AUTISM DEV DISORD, V38, P759, DOI 10.1007/s10803-007-0445-6 Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372 Honda H, 2005, DEV MED CHILD NEUROL, V47, P10, DOI 10.1017/S0012162205000034 Honda H, 1996, BRIT J PSYCHIAT, V169, P228, DOI 10.1192/bjp.169.2.228 Howlin P, 1997, AUTISM, V1, P135, DOI DOI 10.1177/1362361397012003 Juneja M, 2005, INDIAN PEDIATR, V42, P453 Kanner L, 1943, NERV CHILD, V2, P217 Kawamura Y, 2008, PSYCHIAT CLIN NEUROS, V62, P152, DOI 10.1111/j.1440-1819.2008.01748.x Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Matson JL, 2011, RES AUTISM SPECT DIS, V5, P418, DOI 10.1016/j.rasd.2010.06.004 Pereira A, 2008, J PEDIAT, V84, P487, DOI [10.2223/JPED.1828, 10.1590/S0021-75572008000700004] Ruta L, 2011, J AUTISM DEV DISORD, V42, P625 Skuse DH, 2009, J AM ACAD CHILD PSY, V48, P128, DOI 10.1097/CHI.0b013e31819176b8 Skuse DH, 2005, BRIT J PSYCHIAT, V187, P568, DOI 10.1192/bjp.187.6.568 SUGIYAMA T, 1989, J AUTISM DEV DISORD, V19, P87, DOI 10.1007/BF02212720 Sun X, 2010, RES AUTISM SPECT DIS, V4, P156, DOI 10.1016/j.rasd.2009.10.003 TANOUE Y, 1988, J AUTISM DEV DISORD, V18, P155, DOI 10.1007/BF02211943 VOLKMAR FR, 1988, J AUTISM DEV DISORD, V18, P81, DOI 10.1007/BF02211820 Wong V, 2004, PEDIATRICS, V114, P166 ZAMAN SS, 1990, INT J EPIDEMIOL, V19, P613, DOI 10.1093/ije/19.3.613 Zhang X, 2005, BIOMED ENVIRON SCI, V18, P334 NR 40 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 598 EP 607 DI 10.1002/aur.1404 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300008 PM 25277878 ER PT J AU Caceres, AS Keren, N Booth, R Happe, F AF Caceres, Antonia San Jose Keren, Noa Booth, Rhonda Happe, Francesca TI Assessing Theory of Mind Nonverbally in Those With Intellectual Disability and ASD: The Penny Hiding Game SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; intellectual disability; Penny Hiding Game; theory of mind; everyday functioning; adaptive functioning ID AUTISTIC SPECTRUM DISORDERS; TASK-PERFORMANCE; FALSE BELIEF; ROLE-TAKING; CHILDREN; BEHAVIOR; DECEPTION; LANGUAGE; 2-YEAR-OLDS; IMPAIRMENT AB Individuals with autism spectrum disorder (ASD) and low intellectual/language abilities are often omitted from experimental studies because of the challenges of testing these individuals. It is vital to develop appropriate and accessible tasks so that this significant part of the spectrum is not neglected. The theory of mind (ToM) has been extensively assessed in ASD, predominantly in relatively high-functioning individuals with reasonable language skills. This study aims to assess the ToM abilities of a sample of 132 participants with intellectual disability (ID) with and without ASD, matched in verbal mental age (VMA) and chronological age, using a naturalistic and nonverbal deception task: the Penny Hiding Game (PHG). The relationship between performance on the PHG and everyday adaptation was also studied. The PHG proved accessible to most participants, suggesting its suitability for use with individuals with low cognitive skills, attentional problems, and limited language. The ASD+ID group showed significantly more PHG errors, and fewer tricks, than the ID group. PHG performance correlated with Vineland adaptation scores for both groups. VMA was a major predictor of passing the task in both groups, and participants with ASD+ID required, on average, 2 years higher VMA than those with ID only, to achieve the same level of PHG success. VMA moderated the association between PHG performance and real-life social skills for the ASD+ID more than the ID group, suggesting that severely impaired individuals with ASD may rely on verbal ability to overcome their social difficulties, whereas individuals with ID alone may use more intuitive social understanding both in the PHG and everyday situations. Autism Res2014, 7: 608-616. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Caceres, Antonia San Jose] Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, London SE5 8AF, England. [Keren, Noa] Kings Coll London, Sch Med, London SE5 8AF, England. [Booth, Rhonda] Kings Coll London, Inst Child Hlth, London SE5 8AF, England. [Happe, Francesca] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London SE5 8AF, England. RP Caceres, AS (reprint author), Kings Coll London, Inst Psychiat, Dept Forens & Neurodev Sci, POB 23,16 De Crespigny Pk, London SE5 8AF, England. EM antonia.sanjose@kcl.ac.uk FU Institute of Social Psychiatry FX This study has been supported by an Institute of Social Psychiatry grant, awarded to the first author as part of her PhD project. We would like to thank all the staff at the schools that kindly opened their doors to make this project possible: Downsview, Durants, Hatton, Hay Lane, Horizon, Kisharon, Mapledown, Millfields, Oak Lodge, Phoenix, Samuel Rhodes, Trinity, Tysson, West Lea, and Whitmore. CR Aljunied M, 2011, RES AUTISM SPECT DIS, V5, P368, DOI 10.1016/j.rasd.2010.05.002 Ames CS, 2011, J AUTISM DEV DISORD, V41, P357, DOI 10.1007/s10803-010-1049-0 Baron-Cohen S., 2000, UNDERSTANDING OTHER, P3 BARONCOHEN S, 1992, J CHILD PSYCHOL PSYC, V33, P1141, DOI 10.1111/j.1469-7610.1992.tb00934.x BARONCOHEN S, 1986, BRIT J DEV PSYCHOL, V4, P113 BaronCohen S, 1995, NEUROCASE, V1, P101, DOI 10.1080/13554799508402353 BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289 Boucher J, 2012, J CHILD PSYCHOL PSYC, V53, P219, DOI 10.1111/j.1469-7610.2011.02508.x Call J., 2001, ANIM COGN, V3, P207, DOI [10.1007/s100710100078, DOI 10.1007/S100710100078] Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075 Charman T, 1997, J CHILD PSYCHOL PSYC, V38, P725, DOI 10.1111/j.1469-7610.1997.tb01699.x Colle L, 2007, J AUTISM DEV DISORD, V37, P716, DOI 10.1007/s10803-006-0198-7 DEVRIES R, 1970, CHILD DEV, V41, P759, DOI 10.1111/j.1467-8624.1970.tb01029.x Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd Fisher N, 2005, J AUTISM DEV DISORD, V35, P757, DOI 10.1007/s10803-005-0022-9 Frith U., 1994, SOCIAL DEV, V3, P108, DOI DOI 10.1111/J.1467-9507.1994.TB00031.X FRITH U, 1991, TRENDS NEUROSCI, V14, P433, DOI 10.1016/0166-2236(91)90041-R Frith U., 2003, AUTISM EXPLAINING EN Gardner M. F., 1979, EXPRESSIVE ONE WORD Gowen E, 2008, NEUROPSYCHOLOGIA, V46, P1060, DOI 10.1016/j.neuropsychologia.2007.11.004 Gratch G., 1964, HUM DEV, V7, P49 Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022 HAPPE FGE, 1995, CHILD DEV, V66, P843, DOI 10.1111/j.1467-8624.1995.tb00909.x Harris JM, 2008, J AUTISM DEV DISORD, V38, P1241, DOI 10.1007/s10803-007-0502-1 HOWLIN P, 1991, BRIT J DISORD COMMUN, V26, P355 Hughes C, 1997, EUR CHILD ADOLES PSY, V6, P191 Onishi KH, 2005, SCIENCE, V308, P255, DOI 10.1126/science.1107621 OSWALD DP, 1989, J AUTISM DEV DISORD, V19, P119, DOI 10.1007/BF02212723 PERNER J, 1987, BRIT J DEV PSYCHOL, V5, P125 PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515 Reinecke DR, 1997, J AUTISM DEV DISORD, V27, P127, DOI 10.1023/A:1025835706522 Shaked M, 2004, J AUTISM DEV DISORD, V34, P35, DOI 10.1023/B:JADD.0000018072.42845.83 Southgate V, 2007, PSYCHOL SCI, V18, P587, DOI 10.1111/j.1467-9280.2007.01944.x Sparrow S., 2006, VINELAND ADAPTIVE BE, V2nd Sparrow S, 1984, VINELAND ADAPTIVE BE Steele S, 2003, J AUTISM DEV DISORD, V33, P461, DOI 10.1023/A:1025075115100 Sundqvist A., 2010, COMMUNICATION DISORD, V31, P86 Taer-Flusberg H., 2013, AUTISM RES, V6, P468 TAGERFLUSBERG H, 1994, J CHILD PSYCHOL PSYC, V35, P1059, DOI 10.1111/j.1469-7610.1994.tb01809.x White S, 2009, CHILD DEV, V80, P1097, DOI 10.1111/j.1467-8624.2009.01319.x Williams D, 2010, DEVELOPMENTAL SCI, V13, P307, DOI 10.1111/j.1467-7687.2009.00885.x WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5 NR 42 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 608 EP 616 DI 10.1002/aur.1405 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300009 ER PT J AU Lambert, N Wermenbol, V Pichon, B Acosta, S van den Ameele, J Perazzolo, C Messina, D Musumeci, MF Dessars, B De Leener, A Abramowicz, M Vilain, C AF Lambert, Nelle Wermenbol, Vanessa Pichon, Bruno Acosta, Sandra van den Ameele, Jelle Perazzolo, Camille Messina, Diana Musumeci, Maria-Franca Dessars, Barbara De Leener, Anne Abramowicz, Marc Vilain, Catheline TI A Familial Heterozygous Null Mutation of MET in Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; c-MET; social brain; neurodevelopment ID RECEPTOR TYROSINE KINASE; DE-NOVO MUTATIONS; BRAIN-DEVELOPMENT; MOUSE FOREBRAIN; GENETIC VARIANT; ASSOCIATION; EXPRESSION; RISK AB Autism spectrum disorder (ASD) results from interactions of genetic and environmental factors. The MET proto-oncogene has been identified as a candidate gene for autism susceptibility, and is implicated in neurodevelopment and social brain circuitry. Here, we describe the first case of a familial mutation of MET, consisting of an interstitial genomic deletion removing exons 12 through 15, causing a frameshift and premature stop codon, with evidence of nonsense-mediated mRNA decay. On the other allele, patients carried the C allele of the MET promoter rs1858830 polymorphism, known to decrease MET expression and previously associated with autism susceptibility. The heterozygous mutation was associated with autism in one patient, and language and social impairment in a sibling. Our observations delineate the phenotypic spectrum associated with a clearly defined, very likely complete loss of function mutation of MET. Incomplete penetrance in this family was consistent with MET as a partial susceptibility gene for ASD. Implication of MET in normal and pathological brain development opens new perspectives for understanding the pathophysiology of autism and for eventual therapeutical clues. Autism Res2014, 7: 617-622. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Lambert, Nelle; Pichon, Bruno; Dessars, Barbara; De Leener, Anne; Abramowicz, Marc; Vilain, Catheline] Univ Libre Bruxelles, Hop Erasme, ULB Ctr Human Genet, B-1070 Brussels, Belgium. [Lambert, Nelle; Acosta, Sandra; van den Ameele, Jelle; Perazzolo, Camille; Abramowicz, Marc] Univ Libre Bruxelles, IRIBHM, B-1070 Brussels, Belgium. [Wermenbol, Vanessa; Messina, Diana] Univ Libre Bruxelles, Hop Erasme, Dept Paediat Neurol, B-1070 Brussels, Belgium. [van den Ameele, Jelle] Ghent Univ Hosp, Dept Neurol, Ghent, Belgium. [Musumeci, Maria-Franca] Commiss European Communities, European Sch, B-1049 Brussels, Belgium. RP Lambert, N (reprint author), Univ Libre Bruxelles, Hop Erasme, ULB Ctr Human Genet, Route Lennik 808, B-1070 Brussels, Belgium. EM Nelle.Lambert@ulb.ac.be FU Fonds de la Recherche Scientifique Medicale (FRSM) of the Belgian FNRS; Fonds Erasme; Fonds IRIS FX We thank P. Vanderhaeghen for continuous support and interest, and the members of IRIBHM for helpful discussions and advice. We thank the patients and families for participating in the study. N. Lambert is an MD. Postdoctoral Fellow of the FNRS, J. van den Ameele is a Research Fellow of the FNRS, and M. Abramowicz is supported by the Fonds de la Recherche Scientifique Medicale (FRSM) of the Belgian FNRS and by the Fonds Erasme. Patients' parents gave written informed consent. C. Vilain is supported by Fonds IRIS. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Adam D, 2013, NATURE, V496, P416, DOI 10.1038/496416a Baudouin SJ, 2012, SCIENCE, V338, P128, DOI 10.1126/science.1224159 Berg JM, 2012, GENOME BIOL, V13, DOI [10.1186/gb4034, 10.1186/gb-2012-13-7-247] Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103 Campbell DB, 2010, AM J MED GENET B, V153B, P438, DOI 10.1002/ajmg.b.30998 Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180 Campbell DB, 2009, PEDIATRICS, V123, P1018, DOI 10.1542/peds.2008-0819 Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27 Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016 Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002 Girirajan S, 2013, AM J HUM GENET, V92, P221, DOI 10.1016/j.ajhg.2012.12.016 Heuer L, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.48 Jackson PB, 2009, AUTISM RES, V2, P232, DOI 10.1002/aur.87 Judson MC, 2011, J NEURODEV DISORD, V3, P282, DOI 10.1007/s11689-011-9081-8 Judson MC, 2009, J COMP NEUROL, V513, P511, DOI 10.1002/cne.21969 Judson MC, 2010, J COMP NEUROL, V518, P4463, DOI 10.1002/cne.22467 Lambert N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017753 Li XH, 2012, BRAIN RES BULL, V88, P543, DOI 10.1016/j.brainresbull.2012.05.017 Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 Martins GJ, 2011, NEUROSCIENCE, V176, P199, DOI 10.1016/j.neuroscience.2010.12.058 Mukamel Z, 2011, J NEUROSCI, V31, P11437, DOI 10.1523/JNEUROSCI.0181-11.2011 O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989 Plummer JT, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.91 Qiu SF, 2011, J NEUROSCI, V31, P5855, DOI 10.1523/JNEUROSCI.6569-10.2011 Rudie JD, 2012, NEURON, V75, P904, DOI 10.1016/j.neuron.2012.07.010 Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945 Sousa I, 2009, EUR J HUM GENET, V17, P749, DOI 10.1038/ejhg.2008.215 State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924 Thanseem I, 2010, NEUROSCI RES, V68, P137, DOI 10.1016/j.neures.2010.06.014 Trusolino L, 2010, NAT REV MOL CELL BIO, V11, P834, DOI 10.1038/nrm3012 Walsh CA, 2008, CELL, V135, P396, DOI 10.1016/j.cell.2008.10.015 Wu HH, 2013, DEV NEUROSCI-BASEL, V35, P1, DOI 10.1159/000346367 Zhou XA, 2011, PLOS ONE, V6 NR 34 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2014 VL 7 IS 5 BP 617 EP 622 DI 10.1002/aur.1396 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AS0MO UT WOS:000343971300010 PM 24909855 ER PT J AU Geurts, HM van den Bergh, SFWM Ruzzano, L AF Geurts, Hilde M. van den Bergh, Sanne F. W. M. Ruzzano, Laura TI Prepotent Response Inhibition and Interference Control in Autism Spectrum Disorders: Two Meta-Analyses SO AUTISM RESEARCH LA English DT Article DE ASD; autism; inhibition; interference; cognitive control; meta-analysis ID HIGH-FUNCTIONING AUTISM; DEFICIT HYPERACTIVITY DISORDER; LATENT-VARIABLE ANALYSIS; CHOICE REACTION-TIME; COGNITIVE CONTROL; EXECUTIVE FUNCTION; NEURODEVELOPMENTAL DISORDERS; IMPAIRED COGNITION; WORKING-MEMORY; STOP-SIGNAL AB There is a substantial amount of data providing evidence for, but also against the hypothesis that individuals with autism spectrum disorders (ASD) encounter inhibitory control deficits. ASD is often associated with interference control deficits rather than prepotent response inhibition. Moreover, the developmental trajectory for these inhibitory control processes is hypothesized to differ in ASD as compared to typical development. In efforts to gain a more comprehensive perspective of inhibition in ASD, separate quantitative analysis for prepotent response inhibition studies and interference control studies were conducted. Together, these two meta-analyses included 41 studies with a combined sample size of 1,091 people with ASD (M age 14.8 years), and 1,306 typically developing (TD) controls (M age 13.8 years). The meta-analyses indicated that individuals with ASD show increased difficulties in prepotent response inhibition (effect size 0.55) and in interference control (effect size 0.31). In addition, age was a relevant moderator for prepotent response inhibition but not for interference control. Exploratory analyses revealed that when IQ was taken into account, heterogeneity considerably decreased among interference control studies but not among prepotent response inhibition. In contrast to the general belief, both prepotent response inhibition and interference control problems were observed in individuals with ASD. However, a large variation between studies was also found. Therefore, there remain factors beyond inhibition type, age, or IQ that significantly influence inhibitory control performance among individuals with ASD. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Geurts, Hilde M.] Univ Amsterdam, Dept Psychol Brain & Cognit, NL-1018 XA Amsterdam, Netherlands. [Geurts, Hilde M.; van den Bergh, Sanne F. W. M.; Ruzzano, Laura] Dr Leo Kannerhuis, Res & Dev, Ctr Autism, Amsterdam, Netherlands. [Geurts, Hilde M.; van den Bergh, Sanne F. W. M.; Ruzzano, Laura] Dutch Autism & ADHD Res Ctr Arc, Amsterdam, Netherlands. [Geurts, Hilde M.] Univ Amsterdam, Cognit Sci Ctr Amsterdam, NL-1018 XA Amsterdam, Netherlands. RP Geurts, HM (reprint author), Univ Amsterdam, Dept Psychol, Dutch Autism & ADHD Res Ctr ARC, Weesperpl 4, NL-1018 XA Amsterdam, Netherlands. EM H.M.Geurts@uva.nl FU VIDI grant, Netherlands Organization for Scientific Research (NWO) [452-10-003] FX This work is part of the research program "Autism and Aging: A Double Jeopardy, which is financed (VIDI grant number 452-10-003) by the Netherlands Organization for Scientific Research (NWO). Dr. Geurts, M.Sc. van den Bergh, and M.Sc. Ruzzano reported no biomedical financial interests or potential conflicts of interest. CR Adams NC, 2009, J AUTISM DEV DISORD, V39, P1112, DOI 10.1007/s10803-009-0721-8 Adams NC, 2012, J AUTISM DEV DISORD, V42, P1052, DOI 10.1007/s10803-011-1345-3 Agam Y, 2010, NEUROIMAGE, V52, P336, DOI 10.1016/j.neuroimage.2010.04.010 Ames CS, 2007, J AUTISM DEV DISORD, V37, P1761, DOI 10.1007/s10803-006-0309-5 Aron AR, 2011, BIOL PSYCHIAT, V69, pE55, DOI 10.1016/j.biopsych.2010.07.024 Ashwin C, 2006, PSYCHOL MED, V36, P835, DOI 10.1017/S0033291706007203 Barneveld P. S., 2013, J INT NEUROPSYCH SOC, V19, P1 Bishop DVM, 2005, AUTISM, V9, P29, DOI 10.1177/1362361305049028 Brandimonte MA, 2011, MEMORY, V19, P56, DOI 10.1080/09658211.2010.535657 Brian JA, 2003, J CHILD PSYCHOL PSYC, V44, P552, DOI 10.1111/1469-7610.00144 Carter CS, 2005, SCHIZOPHRENIA BULL, V31, P810, DOI 10.1093/schbul/sbi046 Casey BJ, 2001, CLIN NEUROSCI RES, V1, P267, DOI 10.1016/S1566-2772(01)00013-5 Castellanos F. X., 2013, EUROPEAN CHILD ADOLE, V23, P69 Chan AS, 2009, CLIN NEUROPHYSIOL, V120, P1107, DOI 10.1016/j.clinph.2009.04.002 Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y Christ SE, 2011, NEUROPSYCHOLOGY, V25, P690, DOI 10.1037/a0024256 Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005 Corbett BA, 2006, CHILD NEUROPSYCHOL, V12, P335, DOI 10.1080/09297040500350938 Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481 Dichter GS, 2008, PSYCHIAT RES-NEUROIM, V164, P185, DOI 10.1016/j.pscychresns.2007.12.005 Dichter GS, 2007, NEUROIMAGE, V35, P1219, DOI 10.1016/j.neuroimage.2006.12.038 Eagle DM, 2008, PSYCHOPHARMACOLOGY, V199, P439, DOI 10.1007/s00213-008-1127-6 Egner T, 2008, TRENDS COGN SCI, V12, P374, DOI 10.1016/j.tics.2008.07.001 ERIKSEN BA, 1974, PERCEPT PSYCHOPHYS, V16, P143, DOI 10.3758/BF03203267 ESKES GA, 1990, J AUTISM DEV DISORD, V20, P61, DOI 10.1007/BF02206857 Fairchild AJ, 2010, J SCHOOL PSYCHOL, V48, P53, DOI 10.1016/j.jsp.2009.09.001 Fan J, 2003, NEUROIMAGE, V18, P42, DOI 10.1006/nimg.2002.1319 Friedman NP, 2004, J EXP PSYCHOL GEN, V133, P101, DOI 10.1037/0096-3445.133.1.101 Geurts H. M., 2011, J AUTISM DEV DISORD, V42, P665 Geurts HM, 2008, J CHILD PSYCHOL PSYC, V49, P848, DOI 10.1111/j.1469-7610.2008.01916.x Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x Geurts HM, 2009, J AUTISM DEV DISORD, V39, P1603, DOI 10.1007/s10803-009-0786-4 Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Hedges L, 1985, STAT METHODS METAANA Henderson H, 2006, BRAIN COGNITION, V61, P96, DOI 10.1016/j.bandc.2005.12.009 HUGHES C, 1993, DEV PSYCHOL, V29, P498, DOI 10.1037/0012-1649.29.3.498 HUGHES C, 1994, NEUROPSYCHOLOGIA, V32, P477, DOI 10.1016/0028-3932(94)90092-2 Huizenga HM, 2011, BRIT J MATH STAT PSY, V64, P1, DOI 10.1348/000711010X522687 Huizinga M, 2006, NEUROPSYCHOLOGIA, V44, P2017, DOI 10.1016/j.neuropsychologia.2006.01.010 Jahromi LB, 2013, RES AUTISM SPECT DIS, V7, P235, DOI 10.1016/j.rasd.2012.08.012 Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P2234, DOI 10.1016/j.neuropsychologia.2007.02.019 Johnston K, 2011, J AUTISM DEV DISORD, V41, P903, DOI 10.1007/s10803-010-1113-9 Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004 Kilincaslan A, 2010, TURK PSIKIYATR DERG, V21, P289 Kohls G, 2009, DEVELOPMENTAL SCI, V12, P614, DOI 10.1111/j.1467-7687.2009.00816.x Kuntsi J, 2001, J CHILD PSYCHOL PSYC, V42, P199, DOI 10.1017/S0021963001006709 Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018 Larson MJ, 2012, J CHILD PSYCHOL PSYC, V53, P440, DOI 10.1111/j.1469-7610.2011.02498.x Lee PS, 2009, CEREB CORTEX, V19, P1787, DOI 10.1093/cercor/bhn209 Lemon JM, 2011, J AUTISM DEV DISORD, V41, P352, DOI 10.1007/s10803-010-1039-2 LOGAN GD, 1984, J EXP PSYCHOL HUMAN, V10, P276, DOI 10.1037/0096-1523.10.2.276 Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030 MacDonald AW, 2002, J CLIN EXP NEUROPSYC, V24, P873, DOI 10.1076/jcen.24.7.873.8386 Miyake A, 2012, CURR DIR PSYCHOL SCI, V21, P8, DOI 10.1177/0963721411429458 Nigg JT, 2000, PSYCHOL BULL, V126, P220, DOI 10.1037//0033-2909.126.2.220 Ogilvie JM, 2011, CRIMINOLOGY, V49, P1063, DOI 10.1111/j.1745-9125.2011.00252.x Ozonoff S, 1997, J AUTISM DEV DISORD, V27, P59, DOI 10.1023/A:1025821222046 OZONOFF S, 1994, J CHILD PSYCHOL PSYC, V35, P1015, DOI 10.1111/j.1469-7610.1994.tb01807.x Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110 Polderman TJC, 2009, NEUROPSYCHOLOGY, V23, P381, DOI 10.1037/a0014915 Prinzmetal W, 2005, J EXP PSYCHOL GEN, V134, P73, DOI 10.1037/0096-3445.134.1.73 Raymaekers R, 2006, CHILD NEUROPSYCHOL, V12, P349, DOI 10.1080/09297040600760457 Raymaekers R, 2007, J CLIN EXP NEUROPSYC, V29, P418, DOI 10.1080/13803390600737990 Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007 Russell J, 1999, J AUTISM DEV DISORD, V29, P103, DOI 10.1023/A:1023084425406 Salthouse TA, 2010, BRAIN COGNITION, V73, P51, DOI 10.1016/j.bandc.2010.02.003 Sanderson C, 2013, J AUTISM DEV DISORD, V43, P1065, DOI 10.1007/s10803-012-1650-5 Schmitz N, 2006, BIOL PSYCHIAT, V59, P7, DOI 10.1016/j.biopsych.2005.06.007 Semrud-Clikeman M, 2010, J AUTISM DEV DISORD, V40, P1017, DOI 10.1007/s10803-010-0951-9 SIMON JR, 1963, ERGONOMICS, V6, P99, DOI 10.1080/00140136308930679 Sinzig Judith, 2008, Child Adolesc Psychiatry Ment Health, V2, P4, DOI 10.1186/1753-2000-2-4 Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019 Solomon M, 2008, INT J DEV NEUROSCI, V26, P239, DOI 10.1016/j.ijdevneu.2007.11.001 Soreni N, 2009, J ATTEN DISORD, V13, P137, DOI 10.1177/1087054708326110 South M, 2010, BIOL PSYCHOL, V85, P242, DOI 10.1016/j.biopsycho.2010.07.009 Stroop JR, 1935, J EXP PSYCHOL, V18, P643, DOI 10.1037/0096-3445.121.1.15 Swick D, 2011, NEUROIMAGE, V56, P1655, DOI 10.1016/j.neuroimage.2011.02.070 Tanguay PE, 2011, AM J PSYCHIAT, V168, P1142, DOI 10.1176/appi.ajp.2011.11071024 Tye C., 2013, PSYCHOL MED, V15, P1 Vaidya CJ, 2011, DEVELOPMENTAL SCI, V14, P911, DOI 10.1111/j.1467-7687.2011.01041.x Verte S, 2006, J NEUROSCI METH, V151, P5, DOI 10.1016/j.jneumeth.2005.08.023 Viechtbauer W, 2010, J STAT SOFTW, V36, P1 Wostmann NM, 2013, BRAIN COGNITION, V81, P82, DOI 10.1016/j.bandc.2012.09.010 Xiao T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046569 Yoran-Hegesh R, 2009, PSYCHIAT RES, V166, P35, DOI 10.1016/j.psychres.2007.11.015 NR 86 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 407 EP 420 DI 10.1002/aur.1369 PG 14 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300001 PM 24596300 ER PT J AU Sparaci, L Stefanini, S D'Elia, L Vicari, S Rizzolatti, G AF Sparaci, Laura Stefanini, Silvia D'Elia, Lidia Vicari, Stefano Rizzolatti, Giacomo TI What and Why Understanding in Autism Spectrum Disorders and Williams Syndrome: Similarities and Differences SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; Williams syndrome; social cognition; motor skills ID YOUNG-CHILDREN; NEURAL BASIS; MOTOR; INFANTS; HYPERSOCIABILITY; INTENTIONS; DEFICIT; BRAIN; PERCEPTION; MECHANISMS AB Children with autism spectrum disorders (ASD) and children with Williams syndrome (WS) show divergent social phenotypes, but also several similarities in their socio-cognitive deficits. Cross-syndrome direct comparisons could lead to a better understanding of mechanisms that determine deficits in social cognition in the two syndromes. A fundamental factor for social cognition is the ability to understand and predict others' actions (e. g. what action is being done and why it is being done when observing a goal-related act). Here we compared the understanding of others' actions in children with ASD, WS and in children with typical development. Comprehension of what motor act was being done and of why it was being done was assessed with or without contextual cueing using a computer-based task. The results showed that what understanding was impaired in the WS group, but not in the ASD group, which showed mental-age appropriate performance. Why understanding was impaired in both experimental groups. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Sparaci, Laura; Stefanini, Silvia; Rizzolatti, Giacomo] Univ Parma, Dept Neurosci, I-43100 Parma, Italy. [Sparaci, Laura] Natl Res Council CNR Italy, Inst Cognit Sci & Technol ISTC, I-00161 Rome, Italy. [Sparaci, Laura; D'Elia, Lidia; Vicari, Stefano] Bambino Gesu Childrens Hosp IRCCS, Rome, Italy. [Stefanini, Silvia] Local Hlth Unit AUSL, Dept Mental Hlth, Parma, Italy. [Rizzolatti, Giacomo] Italian Inst Technol, Parma Unit, Brain Ctr Social & Motor Cognit, Parma, Italy. RP Sparaci, L (reprint author), Natl Res Council CNR Italy, Inst Cognit Sci & Technol ISTC, Via Nomentana 56, I-00161 Rome, Italy. EM laura.sparaci@istc.cnr.it FU Fondazione Monte Parma; ERC Advanced Grant "Cogsystems" [250013]; Fondazione Handicap Dopodinoi, Onlus; MIUR-FIRB TOUM project [RBFR086HEW] FX The work reported in this paper was supported by: Fondazione Monte Parma and ERC Advanced Grant "Cogsystems" (no. 250013) to G. R.; Fondazione Handicap Dopodinoi, Onlus to S. V.; MIUR-FIRB TOUM project (no. RBFR086HEW) to L. S. We are very grateful to the Italian Williams Syndrome Association (AISW) as well as to the Primary and Secondary Schools San Vitale-Fra' Salimbene Parma and San Francesco D'Assisi Rome for helping us in this study. We wish to thank Dr Patrizio Pasqualetti and Dr Pasquale Rinaldi for their help with statistical analyses. In particular, we wish to thank all the children and families who have participated in this research. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Asada K, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00247 Bello A, 2004, NEUROPSYCHOLOGIA, V42, P201, DOI 10.1016/S0028-3932(03)00172-6 Bello A, 2014, DEV PSYCHOL, V50, P504, DOI 10.1037/a0033375 Bellugi U, 1999, NEUROREPORT, V10, P1653, DOI 10.1097/00001756-199906030-00006 Boria S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005596 Brock J, 2007, DEV PSYCHOPATHOL, V19, P97, DOI 10.1017/S095457940707006X Brock J., 2008, SOCIAL COGNITION DEV Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104 Csibra G., 2013, NAVIGATING SOCIAL WO CUTKOSKY MR, 1989, IEEE T ROBOTIC AUTOM, V5, P269, DOI 10.1109/70.34763 Dewey D, 2007, J INT NEUROPSYCH SOC, V13, P246, DOI 10.1017/S1355617707070270 Doyle TF, 2004, AM J MED GENET A, V124A, P263, DOI 10.1002/ajmg.a.20416 Dunn L. M., 1981, PEABODY PICTURE VOCA Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734 Fabbri-Destro M, 2009, EXP BRAIN RES, V192, P521, DOI 10.1007/s00221-008-1578-3 Fogassi L, 2005, SCIENCE, V308, P662, DOI 10.1126/science.1106138 Forti S, 2011, RES AUTISM SPECT DIS, V5, P834, DOI 10.1016/j.rasd.2010.09.013 Gazzaniga M., 2008, HUMAN SCI WHAT MAKES Grossmann T, 2007, SOC COGN AFFECT NEUR, V2, P284, DOI 10.1093/scan/nsm025 Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356 Iacoboni M, 2005, PLOS BIOL, V3, P529, DOI 10.1371/journal.pbio.0030079 Inui T, 2013, JPN PSYCHOL RES, V55, P99, DOI 10.1111/jpr.12004 Izawa J, 2012, AUTISM RES, V5, P124, DOI 10.1002/aur.1222 Jackowski AP, 2009, EUR J PAEDIATR NEURO, V13, P305, DOI 10.1016/j.ejpn.2008.07.002 Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y Jarvinen A., 2013, CURRENT OPINION NEUR, V23, P1 Jones W, 2000, J COGNITIVE NEUROSCI, V12, P30, DOI 10.1162/089892900561968 Klein-Tasman BP, 2011, J AUTISM DEV DISORD, V41, P341, DOI 10.1007/s10803-010-1060-5 Klein-Tasman BP, 2003, DEV NEUROPSYCHOL, V23, P269, DOI 10.1207/S15326942DN231&2_12 Lincoln AJ, 2007, J AM ACAD CHILD PSY, V46, P323, DOI 10.1097/chi.0b013e31802b9522 Linkenauger SA, 2012, AUTISM RES, V5, P352, DOI 10.1002/aur.1248 Lord C., 2005, AUTISM DIAGNOSTIC OB Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Martens MA, 2008, J CHILD PSYCHOL PSYC, V49, P576, DOI 10.1111/j.1469-7610.2008.01887.x Meyer-Lindenberg A, 2006, NAT REV NEUROSCI, V7, P380, DOI 10.1038/nrn1906 Meyer-Lindenberg A, 2004, NEURON, V43, P623, DOI 10.1016/j.neuron.2004.08.014 Mostofsky SH, 2006, J INT NEUROPSYCH SOC, V12, P314, DOI 10.1017/S1355617706060437 Mostofsky SH, 2011, NEUROSCIENTIST, V17, P437, DOI 10.1177/1073858410392381 Ogawa K, 2011, NEUROIMAGE, V56, P728, DOI 10.1016/j.neuroimage.2010.10.043 Phillips AT, 2002, COGNITION, V85, P53, DOI 10.1016/S0010-0277(02)00073-2 Roid G. H., 2002, LEITER R LEITER INT Southgate V, 2009, BIOL LETTERS, V5, P769, DOI 10.1098/rsbl.2009.0474 Sparaci L, 2012, NEUROPSYCHOLOGIA, V50, P1639, DOI 10.1016/j.neuropsychologia.2012.03.019 Tager-Flusberg H, 2006, SOC COGN AFFECT NEUR, V1, P175, DOI 10.1093/scan/nsl035 Teitelbaum P, 1998, P NATL ACAD SCI USA, V95, P13982, DOI 10.1073/pnas.95.23.13982 Thoermer C, 2013, J EXP CHILD PSYCHOL, V116, P499, DOI 10.1016/j.jecp.2012.12.007 Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129 Trinsempolou E., 2006, WORLD J PEDIATR, V2, P288 Vivanti G, 2011, DEV PSYCHOL, V47, P841, DOI 10.1037/a0023105 von Hofsten C., 2012, FRONT INT NEUROSCI, V6, P1 von Hofsten C, 2005, INFANCY, V8, P217, DOI 10.1207/s15327078in0803_2 Walenski M, 2008, J AUTISM DEV DISORD, V38, P1395, DOI 10.1007/s10803-007-0513-y Woodward AL, 2000, PSYCHOL SCI, V11, P73, DOI 10.1111/1467-9280.00218 Zalla T, 2010, EXP BRAIN RES, V201, P809, DOI 10.1007/s00221-009-2096-7 NR 55 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 421 EP 432 DI 10.1002/aur.1370 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300002 PM 24604708 ER PT J AU Warner, G Moss, J Smith, P Howlin, P AF Warner, Georgina Moss, Joanna Smith, Patrick Howlin, Patricia TI Autism Characteristics and Behavioural Disturbances in similar to 500 Children with Down's Syndrome in England and Wales SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; Down's syndrome; social communication questionnaire; strengths and difficulties questionnaire ID FRAGILE-X-SYNDROME; SPECTRUM DISORDERS; DIFFICULTIES QUESTIONNAIRE; PREVALENCE; DIAGNOSIS; STRENGTHS; CHECKLIST; VALIDITY; PROJECT AB Recent research shows that a significant minority of children with Down's syndrome (DS) also meet diagnostic criteria for an autism spectrum disorder (ASD). The present study investigated what proportion of children aged 6-15 years with a confirmed diagnosis of DS in England and Wales display autistic-type behaviours, and explored the characteristics of this group of children. The Social Communication Questionnaire (SCQ) was used to screen for autism characteristics and the Strengths and Difficulties Questionnaire (SDQ) to explore behavioural difficulties. The proportion of children who met the cut-off score for ASD on the SCQ (total score >= 15) was 37.7% (95% CI: 33.4-42.0%); for autism (total score >= 22) the proportion was 16.5% (95% CI: 13.2-19.8%). Children who met the cut-off for ASD were significantly more likely to be reported as having emotional symptoms, conduct problems and hyperactivity on the SDQ than children who scored well below cut-off (total score < 10). However, the profile of their autism characteristics on the SCQ was atypical compared with individuals with idiopathic ASD. The pervasiveness of ASD in children with DS in England and Wales is substantially higher than in the general population. These children also experience significantly greater behavioural problems than children with DS only. Early detection of autism characteristics is important for appropriate intervention. However, the unusual profile of autism characteristics in this group may affect the recognition of the disorder and hinder the implementation of appropriate interventions. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Warner, Georgina; Smith, Patrick; Howlin, Patricia] Kings Coll London, Inst Psychiat, Dept Psychol, London SE5 8AF, England. [Moss, Joanna] Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England. [Moss, Joanna] UCL, Inst Cognit Neurosci, London, England. [Howlin, Patricia] Univ Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia. RP Warner, G (reprint author), Kings Coll London, Inst Psychiat, Dept Psychol, London SE5 8AF, England. EM georgina.warner@kcl.ac.uk RI Moss, Jo/C-8812-2009 FU Baily Thomas Research Trust FX We are grateful to the UK Down's Syndrome Association, and particularly to Stuart Mills, for their help with participant recruitment, and to Ellie Walsh and Jennie Cox for their help with the survey distribution, as well as to all the families who participated in the study. This study was funded by a PhD studentship from the Baily Thomas Research Trust. CR Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444 Bolte S, 2008, J AM ACAD CHILD PSY, V47, P719, DOI 10.1097/CHI.0b013e31816c42bd Capone GT, 2005, AM J MED GENET A, V134A, P373, DOI 10.1002/ajmg.a.30622 Carter JC, 2007, AM J MED GENET B, V144B, P87, DOI 10.1002/ajmg.b.30407 Castillo H, 2008, J DEV BEHAV PEDIATR, V29, P89, DOI 10.1097/DBP.0b013e318165c78d DiGuiseppi C, 2010, J DEV BEHAV PEDIATR, V31, P181, DOI 10.1097/DBP.0b013e3181d5aa6d Eaves L.C., 2006, J DEV BEHAV PEDIATR, V27, P95, DOI DOI 10.1097/00004703-200604002-00007 Finestack LH, 2010, J SPEECH LANG HEAR R, V53, P1334, DOI 10.1044/1092-4388(2010/09-0125) Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557 Freeman SB, 2007, PUBLIC HEALTH REP, V122, P62 GHAZIUDDIN M, 1992, J INTELL DISABIL RES, V36, P449 Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015 Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x Hall SS, 2010, J AM ACAD CHILD PSY, V49, P921, DOI 10.1016/j.jaac.2010.07.001 HOWLIN P, 1995, DEV MED CHILD NEUROL, V37, P406 Ji NY, 2011, J INTELL DISABIL RES, V55, P1064, DOI 10.1111/j.1365-2788.2011.01465.x Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lowenthal R, 2007, J AUTISM DEV DISORD, V37, P1394, DOI 10.1007/s10803-007-0374-4 Magyar CI, 2012, J DEV BEHAV PEDIATR, V33, P134, DOI 10.1097/DBP.0b013e318240d3d9 Molloy CA, 2009, J INTELL DISABIL RES, V53, P143, DOI 10.1111/j.1365-2788.2008.01138.x Morris JK, 2009, BMJ-BRIT MED J, V339, pb3794 Moss J, 2013, AJIDD-AM J INTELLECT, V118, P55, DOI 10.1352/1944-7558-118.1.55 Moss J, 2013, AUTISM, V17, P390, DOI 10.1177/1362361312442790 Moss J., 2011, OXFORD HDB INTELLECT Numis AL, 2011, NEUROLOGY, V76, P981, DOI 10.1212/WNL.0b013e3182104347 Office for National Statistics, 2007, ENGL IND DEPR REP Rasmussen P, 2001, DEV MED CHILD NEUROL, V43, P750, DOI 10.1017/S0012162201001372 Rosner BA, 2004, J APPL RES INTELLECT, V17, P209, DOI 10.1111/j.1468-3148.2004.00200.x Rutter M., 1985, CHILD ADOLESCENT PSY Rutter M., 2003, AUTISM DIAGNOSTIC IN Rutter M., 2003, SOCIAL COMMUNICATION Wiseman F. K., 2009, HUM MOL GENET, V18, P75 NR 33 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 433 EP 441 DI 10.1002/aur.1371 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300003 PM 24664986 ER PT J AU Murphy, JW Foxe, JJ Peters, JB Molholm, S AF Murphy, Jeremy W. Foxe, John J. Peters, Joanna B. Molholm, Sophie TI Susceptibility to Distraction in Autism Spectrum Disorder: Probing the Integrity of Oscillatory Alpha-Band Suppression Mechanisms SO AUTISM RESEARCH LA English DT Article DE autism; EEG; oscillations; attention ID SELECTIVE VISUAL-ATTENTION; EVENT-RELATED POTENTIALS; SPATIAL ATTENTION; VISUOSPATIAL ATTENTION; INNER SPEECH; FUNCTIONAL CONNECTIVITY; CORTICAL CONNECTIVITY; OCCIPITAL CORTEX; CHILDREN; EEG AB When attention is directed to one information stream over another, the brain can be configured in advance to selectively process the relevant stream and suppress potentially distracting inputs. One key mechanism of suppression is through the deployment of anticipatory alpha-band (similar to 10 Hz) oscillatory activity, with greater alpha-band power observed in cortical regions that will ultimately process the distracting stream. Atypical attention has been implicated in autism spectrum disorder (ASD), including greater interference by distracting task-irrelevant inputs. Here we tested the integrity of these alpha-band mechanisms in ASD using an intersensory attention task. Electroencephalography (EEG) was recorded while participants were cued on a trial-by-trial basis to selectively deploy attention to the visual or auditory modality in anticipation of a target within the cued modality. Whereas typically developing (TD) children showed the predicted alpha-band modulation, with increased alpha-band power over parieto-occipital scalp when attention was deployed to the auditory compared with the visual modality, this differential pattern was entirely absent at the group level in the ASD cohort. Further, only the ASD group showed impaired performance due to the presence of task-irrelevant sensory information. These data suggest that impaired modulation of alpha-band activity plays a role in increased distraction from extraneous sensory inputs in ASD. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Murphy, Jeremy W.; Foxe, John J.; Peters, Joanna B.; Molholm, Sophie] Albert Einstein Coll Med, Sheryl & Daniel R Tishman Cognit Neurophysiol Lab, Childrens Evaluat & Rehabil Ctr, Dept Pediat, Bronx, NY 10461 USA. [Murphy, Jeremy W.; Foxe, John J.; Peters, Joanna B.; Molholm, Sophie] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA. [Murphy, Jeremy W.; Foxe, John J.; Molholm, Sophie] CUNY City Coll, Dept Psychol, Program Cognit Neurosci, New York, NY 10031 USA. [Murphy, Jeremy W.; Foxe, John J.; Molholm, Sophie] CUNY City Coll, Dept Biol, Program Cognit Neurosci, New York, NY 10031 USA. [Peters, Joanna B.] Yeshiva Univ, Ferkauf Grad Sch Psychol, Program Clin Psychol, Bronx, NY USA. RP Molholm, S (reprint author), Albert Einstein Coll Med, Sheryl & Daniel R Tishman Cognit Neurophysiol Lab, Childrens Evaluat & Rehabil Ctr, Dept Pediat, Van Etten Bldg,Wing 1C,1225 Morris Pk Ave, Bronx, NY 10461 USA. EM sophie.molholm@einstein.yu.edu FU U.S. National Institute of Mental Health [MH085322]; Eunice Kennedy Shriver National Institute of Child Health & Human Development [NICHD P30 HD071593] FX Primary funding for this work was provided by a grant from the U.S. National Institute of Mental Health (MH085322 to S. M and J.J.F). The Human Clinical Phenotyping Core, where the children enrolled in this study were clinically evaluated, is a facility of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (IDDRC) which is funded through a center grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD P30 HD071593). CR Adams NC, 2012, J AUTISM DEV DISORD, V42, P1052, DOI 10.1007/s10803-011-1345-3 Banerjee S, 2011, J NEUROSCI, V31, P9923, DOI 10.1523/JNEUROSCI.4660-10.2011 BELL AJ, 1995, NEURAL COMPUT, V7, P1129, DOI 10.1162/neco.1995.7.6.1129 Benjamini Y, 2001, ANN STAT, V29, P1165 Berger H., 1929, EUR ARCH PSY CLIN N, V87, P527, DOI DOI 10.1007/BF01797193 Bollimunta A, 2011, J NEUROSCI, V31, P4935, DOI 10.1523/JNEUROSCI.5580-10.2011 BURACK JA, 1994, J ABNORM PSYCHOL, V103, P535, DOI 10.1037/0021-843X.103.3.535 Buschman TJ, 2012, NEURON, V76, P838, DOI 10.1016/j.neuron.2012.09.029 Capotosto P, 2009, J NEUROSCI, V29, P5863, DOI 10.1523/JNEUROSCI.0539-09.2009 Casanova MF, 2009, PHILOS T R SOC B, V364, P1433, DOI 10.1098/rstb.2008.0331 Chan AS, 2006, J CHILD NEUROL, V21, P391 Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y Christ SE, 2011, NEUROPSYCHOLOGY, V25, P690, DOI 10.1037/a0024256 CIESIELSKI KT, 1990, ELECTROEN CLIN NEURO, V75, P207, DOI 10.1016/0013-4694(90)90174-I CIESIELSKI KT, 1995, NEUROPSYCHOLOGIA, V33, P225, DOI 10.1016/0028-3932(94)00094-6 Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013 CORBETTA M, 1993, J NEUROSCI, V13, P1202 COURCHESNE E, 1994, BEHAV NEUROSCI, V108, P848, DOI 10.1037//0735-7044.108.5.848 Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001 Delorme A, 2004, J NEUROSCI METH, V134, P9, DOI 10.1016/j.jneumeth.2003.10.009 DESIMONE R, 1995, ANNU REV NEUROSCI, V18, P193, DOI 10.1146/annurev.neuro.18.1.193 de Vries M, 2012, J AUTISM DEV DISORD, V42, P2558, DOI 10.1007/s10803-012-1512-1 Dockree PM, 2007, EUR J NEUROSCI, V25, P900, DOI 10.1111/j.1460-9568.2007.05324.x Doricchi F, 2003, NEUROREPORT, V14, P2239, DOI 10.1097/01.wnr.0000091132.75061.64 ERIKSEN BA, 1974, PERCEPT PSYCHOPHYS, V16, P143, DOI 10.3758/BF03203267 Foxe JJ, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00154 Foxe JJ, 1998, NEUROREPORT, V9, P3929, DOI 10.1097/00001756-199812010-00030 Fries P, 2001, SCIENCE, V291, P1560, DOI 10.1126/science.1055465 Fu KMG, 2001, COGNITIVE BRAIN RES, V12, P145, DOI 10.1016/S0926-6410(01)00034-9 Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006 Gomez-Ramirez M, 2011, J NEUROSCI, V31, P18556, DOI 10.1523/JNEUROSCI.2164-11.2011 Gomez-Ramirez M, 2009, BRAIN TOPOGR, V22, P44, DOI 10.1007/s10548-008-0068-z Gomez-Ramirez M, 2007, CLIN NEUROPHARMACOL, V30, P25, DOI 10.1097/01.WNF.0000240940.13876.17 Green D. M., 1966, SIGNAL DETECTION THE Hanslmayr S, 2007, NEUROIMAGE, V37, P1465, DOI 10.1016/j.neuroimage.2007.07.011 Iarocci G, 2004, J AUTISM DEV DISORD, V34, P257, DOI 10.1023/B:JADD.0000029548.84041.69 Isler JR, 2010, CLIN NEUROPHYSIOL, V121, P2035, DOI 10.1016/j.clinph.2010.05.004 Just MA, 2012, NEUROSCI BIOBEHAV R, V36, P1292, DOI 10.1016/j.neubiorev.2012.02.007 Kelly SP, 2009, EUR J NEUROSCI, V30, P2224, DOI [10.1111/j.1460-9568.2009.06980.x, 10.1111/j.1460-9568.2009.6980.x] Kelly SP, 2006, J NEUROPHYSIOL, V95, P3844, DOI 10.1152/jn.01234.2005 Klimesch W, 2007, BRAIN RES REV, V53, P63, DOI 10.1016/j.brainresrev.2006.06.003 Lazarev VV, 2010, CLIN NEUROPHYSIOL, V121, P145, DOI 10.1016/j.clinph.2009.10.010 Lidstone JSM, 2009, J AUTISM DEV DISORD, V39, P1222, DOI 10.1007/s10803-009-0731-6 Lord C., 1999, AUTISM DIAGNOSTIC OB LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 LOVAAS OI, 1971, J ABNORM PSYCHOL, V77, P211, DOI 10.1037/h0031015 Mathewson KJ, 2012, CLIN NEUROPHYSIOL, V123, P1798, DOI 10.1016/j.clinph.2012.02.061 MESULAM MM, 1981, ANN NEUROL, V10, P309, DOI 10.1002/ana.410100402 Milne E, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00051 Miyake A, 2004, ACTA PSYCHOL, V115, P123, DOI 10.1016/j.actpsy.2003.12.004 Muller RA, 2011, CEREB CORTEX, V21, P2233, DOI 10.1093/cercor/bhq296 Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012 Ohta H, 2012, NEUROIMAGE, V61, P1176, DOI 10.1016/j.neuroimage.2012.03.042 Pascualvaca DM, 1998, J AUTISM DEV DISORD, V28, P467, DOI 10.1023/A:1026091809650 Poljac E, 2010, Q J EXP PSYCHOL, V63, P401, DOI 10.1080/17470210902990803 Reed P, 2012, J AUTISM DEV DISORD, V42, P947, DOI 10.1007/s10803-011-1324-8 Remington AM, 2012, J ABNORM PSYCHOL, V121, P544, DOI 10.1037/a0027670 Rihs TA, 2007, EUR J NEUROSCI, V25, P603, DOI 10.1111/j.1460-9568.2007.05278.x Roach BJ, 2008, SCHIZOPHRENIA BULL, V34, P907, DOI 10.1093/schbul/sbn093 Romei V, 2010, J NEUROSCI, V30, P8692, DOI 10.1523/JNEUROSCI.0160-10.2010 Ross LA, 2011, EUR J NEUROSCI, V33, P2329, DOI 10.1111/j.1460-9568.2011.07685.x Ross Lars A, 2007, Cereb Cortex, V17, P1147, DOI 10.1093/cercor/bhl024 Sahyoun CP, 2010, BRAIN COGNITION, V73, P180, DOI 10.1016/j.bandc.2010.05.002 Shukla DK, 2011, J CHILD PSYCHOL PSYC, V52, P286, DOI 10.1111/j.1469-7610.2010.02342.x Snyder AC, 2010, J NEUROSCI, V30, P4024, DOI 10.1523/JNEUROSCI.5684-09.2010 Stoet G, 2011, EUR J DEV PSYCHOL, V8, P244, DOI 10.1080/17405629.2010.492000 Szczepanski SM, 2010, J NEUROSCI, V30, P148, DOI 10.1523/JNEUROSCI.3862-09.2010 Teder-Salejarvi WA, 2005, COGNITIVE BRAIN RES, V23, P221, DOI 10.1016/j.cogbrainres.2004.10.021 Thiebaut de Schotten M., 2005, SCIENCE, V309, P2226, DOI DOI 10.1126/SCIENCE.1116251 Thomas C, 2011, CORTEX, V47, P863, DOI 10.1016/j.cortex.2010.07.006 Thut G, 2006, J NEUROSCI, V26, P9494, DOI 10.1523/JNEUROSCI.0875-06.2006 TOWNSEND J, 1994, J COGNITIVE NEUROSCI, V6, P220, DOI 10.1162/jocn.1994.6.3.220 Uhlhaas Peter J, 2006, Neuron, V52, P155, DOI 10.1016/j.neuron.2006.09.020 WAINWRIGHTSHARP JA, 1993, J AUTISM DEV DISORD, V23, P1, DOI 10.1007/BF01066415 Wallace GL, 2009, J AUTISM DEV DISORD, V39, P1735, DOI 10.1007/s10803-009-0802-8 Weschler D, 2011, WECHSLER ABBREVIATED Weschler D, 2003, WECHSLER INTELLIGENC Weschler D., 1999, WECHSLER ABBREVIATED WETHERILL GB, 1965, BRIT J MATH STAT PSY, V18, P1 Whitehouse AJO, 2006, J CHILD PSYCHOL PSYC, V47, P857, DOI 10.1111/j.1469-7610.2006.01624.x Williams DM, 2010, J AUTISM DEV DISORD, V40, P907, DOI 10.1007/s10803-010-0936-8 Worden MS, 2000, J NEUROSCI, V20, part. no. Yamagishi N, 2008, BRAIN RES, V1197, P115, DOI 10.1016/j.brainres.2007.12.063 NR 83 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 442 EP 458 DI 10.1002/aur.1374 PG 17 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300004 PM 24678054 ER PT J AU Smith, RM Banks, W Hansen, E Sadee, W Herman, GE AF Smith, Ryan M. Banks, Wesley Hansen, Emily Sadee, Wolfgang Herman, Gail E. TI Family-Based Clinical Associations and Functional Characterization of the Serotonin 2A Receptor Gene (HTR2A) in Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE autism; serotonin; gene expression; HTR2A; rs6311; monoamine ID DIAGNOSTIC OBSERVATION SCHEDULE; GENOME-WIDE ASSOCIATION; COPY NUMBER VARIATION; DE-NOVO MUTATIONS; 5-HT2A RECEPTOR; SYNAPTIC PATHOPHYSIOLOGY; MESSENGER-RNA; COMMON; CHILDREN; POLYMORPHISMS AB The serotonin 2A receptor gene (HTR2A) harbors two functional single nucleotide polymorphisms (SNPs) that are frequent in populations of African and European descent; rs6311, which affects mRNA expression, and rs6314, which changes the amino acid sequence of the encoded protein and affects the signaling properties of the receptor. Multiple clinical associations support a role for these SNPs in cognitive and neuropsychiatric phenotypes, although studies in autism spectrum disorder (ASD) remain equivocal. Here, we tested transmission disequilibrium of rs6311 and rs6314 in a cohort of 158 ASD trios (simplex and multiplex), observing significant under-transmission of the minor "A" allele of rs6311 to offspring with ASD (permuted P = 0.0004). Consistent with our previous findings in the dorsolateral prefrontal cortex of unaffected individuals, rs6311/A decreases expression of HTR2A mRNA with an extended 5' untranslated region (UTR) in the frontopolar cortex in brain samples from 54 ASD patients and controls. Interpreting the clinical results in the context of our mRNA expression analysis, we speculate that any risk associated with rs6311 is conferred by greater expression of the long 5' UTR mRNA isoform. The current study corroborates earlier associations between rs6311 and ASD in a family study, supporting the hypothesis that rs6311 plays a modulatory role in ASD risk. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Smith, Ryan M.; Sadee, Wolfgang] Ohio State Univ, Dept Pharmacol, Coll Med, Ctr Pharmacogen, Columbus, OH 43210 USA. [Banks, Wesley; Hansen, Emily; Herman, Gail E.] Ohio State Univ, Nationwide Childrens Hosp, Res Inst, Ctr Mol & Human Genet, Columbus, OH 43210 USA. [Banks, Wesley; Hansen, Emily; Herman, Gail E.] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA. [Sadee, Wolfgang] Ohio State Univ, Dept Pharm, Columbus, OH 43210 USA. [Sadee, Wolfgang] Ohio State Univ, Dept Psychiat, Columbus, OH 43210 USA. [Sadee, Wolfgang] Ohio State Univ, Dept Human Genet Internal Med, Columbus, OH 43210 USA. [Sadee, Wolfgang] Ohio State Univ, Dept Environm Hlth Sci, Columbus, OH 43210 USA. RP Smith, RM (reprint author), Ohio State Univ, Dept Pharmacol, 5184A Graves Hall,333 W10th Ave, Columbus, OH 43210 USA. EM Ryan.Smith2@osumc.edu FU National Institute of General Medical Sciences [U01GM092655]; United States Air Force Department of Defense [FA7014-09-2-0004, FA8650-12-2-6359] FX The authors declare no competing interests. This work was supported by the National Institute of General Medical Sciences (U01GM092655 to W. S.) and the United States Air Force Department of Defense (FA7014-09-2-0004 and FA8650-12-2-6359 to Gail E. Herman). We are grateful to all the families participating in the CORA registry. We thankfully acknowledge Harvard Brain Tissue Resource Center and the NICHD Brain and Tissue Bank for providing brain tissues, granted to Ryan M. Smith and Wolfgang Sadee from the Autism Tissue Program, made possible by the donations of generous family members. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301 Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307 Arranz MJ, 1998, SCHIZOPHR RES, V32, P93, DOI 10.1016/S0920-9964(98)00032-2 Auerbach BD, 2011, NATURE, V480, P63, DOI 10.1038/nature10658 Baudouin SJ, 2012, SCIENCE, V338, P128, DOI 10.1126/science.1224159 Benvenuto A, 2009, WORLD J PEDIATR, V5, P169, DOI 10.1007/s12519-009-0033-2 Beversdorf DQ, 2012, J NEUROPSYCH CLIN N, V24, P191, DOI 10.1176/appi.neuropsych.11080202 Bray NJ, 2004, MOL PSYCHIATR, V9, P109, DOI 10.1038/sj.mp.4001366 Cho IH, 2007, BRAIN RES, V1139, P34, DOI 10.1016/j.brainres.2007.01.002 Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9 Connolly JJ, 2013, CHILD DEV, V84, P17, DOI 10.1111/j.1467-8624.2012.01838.x Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008 COOK EH, 1993, LIFE SCI, V52, P2005, DOI 10.1016/0024-3205(93)90685-V Cottrell CE, 2011, AUTISM RES, V4, P189, DOI 10.1002/aur.184 Davies MA, 2006, PHARMACOGENOMICS J, V6, P42, DOI 10.1038/sj.tpj.6500342 Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002 Fukuda Y, 2006, BIOL PSYCHIAT, V60, P1331, DOI 10.1016/j.biopsych.2006.06.024 Girgis RR, 2011, PSYCHIAT RES-NEUROIM, V194, P230, DOI 10.1016/j.pscychresns.2011.04.007 Goldberg J, 2009, J AUTISM DEV DISORD, V39, P97, DOI 10.1007/s10803-008-0604-4 Gorwood P, 2003, EUR J PHARMACOL, V480, P163, DOI 10.1016/j.ejphar.2003.08.103 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Guhathakurta S, 2009, NEUROCHEM INT, V55, P754, DOI 10.1016/j.neuint.2009.07.008 Hazelwood LA, 2004, MOL PHARMACOL, V66, P1293 Herault J, 1996, PSYCHIAT RES, V65, P33, DOI 10.1016/0165-1781(96)02882-X Hranilovic D, 2009, J NEURAL TRANSM, V116, P493, DOI 10.1007/s00702-009-0192-2 Hranilovic D, 2010, PSYCHIAT RES, V178, P556, DOI 10.1016/j.psychres.2010.04.007 Jakab RL, 1998, P NATL ACAD SCI USA, V95, P735, DOI 10.1073/pnas.95.2.735 Kato M, 2010, MOL PSYCHIATR, V15, P473, DOI 10.1038/mp.2008.116 Kazek B, 2010, ACTA NEUROBIOL EXP, V70, P232 Kling A, 2008, ANN RHEUM DIS, V67, P1111, DOI 10.1136/ard.2007.074948 Lee YH, 2012, RHEUMATOL INT, V32, P417, DOI 10.1007/s00296-010-1678-9 Lerer B, 2005, INT J NEUROPSYCHOPH, V8, P411, DOI 10.1017/S1461145705005389 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x Makkonen I, 2008, DEV MED CHILD NEUROL, V50, P593, DOI 10.1111/j.1469-8749.2008.03027.x Marshall CR, 2012, METHODS MOL BIOL, V838, P115, DOI 10.1007/978-1-61779-507-7_5 Martaskova D, 2009, FOLIA BIOL-PRAGUE, V55, P192 Matsunami N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0052239 MCBRIDE PA, 1989, ARCH GEN PSYCHIAT, V46, P213 Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657 Murphy DGM, 2006, AM J PSYCHIAT, V163, P934, DOI 10.1176/appi.ajp.163.5.934 O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989 O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835 Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 Polesskaya OO, 2002, J NEUROSCI RES, V67, P812, DOI 10.1002/jnr.10173 Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795 Ramanathan S, 2009, AM J GERIAT PSYCHIAT, V17, P839, DOI 10.1097/JGP.0b013e3181ab8c3f Scott LJ, 2008, CNS DRUGS, V22, P259, DOI 10.2165/00023210-200822030-00006 Smith RM, 2013, BIOL PSYCHIAT, V73, P546, DOI 10.1016/j.biopsych.2012.09.028 Veenstra-VanderWeele J, 2002, AM J MED GENET, V114, P277, DOI 10.1002/ajmg.10192 Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490 Yu TW, 2013, NEURON, V77, P259, DOI 10.1016/j.neuron.2012.11.002 Zafeiriou DI, 2007, BRAIN DEV-JPN, V29, P257, DOI 10.1016/j.braindev.2006.09.003 NR 55 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 459 EP 467 DI 10.1002/aur.1383 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300005 PM 24753316 ER PT J AU McCormick, C Hessl, D Macari, SL Ozonoff, S Green, C Rogers, SJ AF McCormick, Carolyn Hessl, David Macari, Suzanne L. Ozonoff, Sally Green, Cherie Rogers, Sally J. TI Electrodermal and Behavioral Responses of Children With Autism Spectrum Disorders to Sensory and Repetitive Stimuli SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; psychophysiology; sensory; repetitive behaviors ID DEVELOPMENTAL DELAYS; YOUNG-CHILDREN; MISSING DATA; INDIVIDUALS; INTEGRATION; PATTERNS; MOTOR; AGE AB Parents frequently report that their children with autism spectrum disorders (ASD) respond atypically to sensory stimuli. Repetitive behaviors are also part of the ASD behavioral profile. Abnormal physiological arousal may underlie both of these symptoms. Electrodermal activity (EDA) is an index of sympathetic nervous system arousal. The goals of this study were twofold: (1) to pilot methods for collecting EDA data in young children and (2) to examine hypothesized relationships among EDA, and sensory symptoms and repetitive behaviors in children with ASD as compared with children with typical development. EDA was recorded on 54 young children with ASD and on 33 children with typical development (TD) during a protocol that included baseline, exposure to sensory and repetitive stimuli, and play. Parents completed standardized questionnaires regarding their child's sensory symptoms and repetitive behaviors. Frequency and type of repetitive behavior during play was coded offline. Comparisons between EDA data for ASD and TD groups indicated no significant between-group differences in any measures. Parents of children with ASD reported more abnormal responses to sensory stimuli and more repetitive behaviors, but scores on these measures were not significantly correlated with EDA or with frequency of observed repetitive behaviors. Parent report of frequency and severity of sensory symptoms was significantly correlated with reports of repetitive behaviors in both groups. Although parents of children with ASD report high levels of sensory symptoms and repetitive behaviors, these differences are not related to measured EDA arousal or reactivity. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [McCormick, Carolyn; Hessl, David; Ozonoff, Sally; Rogers, Sally J.] Univ Calif Davis, MIND Inst, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA. [Macari, Suzanne L.] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA. [Green, Cherie] La Trobe Univ, Olga Tennison Autism Res Ctr, Melbourne, Vic, Australia. RP McCormick, C (reprint author), Univ Calif Davis, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA. EM carolyn.mccormick@ucdmc.ucdavis.edu FU UC Davis MIND Institute FX This research was conducted as part of the Autism Phenome Project and supported by the UC Davis MIND Institute. We would like to acknowledge Cynthia Zierhut, Lisa Cochran, Susan Rumberg, and Lou Ann Barnett for their roles on the project, as well as Jennifer Bernstein and Olha Kalish for help with coding. We want to thank all of the families who made this research possible. CR ADRIEN JL, 1993, J AM ACAD CHILD PSY, V32, P617, DOI 10.1097/00004583-199305000-00019 Adrien J.L., 1992, INT J CHILD ADOLESCE, V55, P71 American Psychiatric Association, 2013, DIAGN STAT MAN MENT Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2 Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650 Baranek GT, 2013, DEV PSYCHOPATHOL, V25, P307, DOI 10.1017/S0954579412001071 Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063 Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3 BERNAL ME, 1970, PSYCHOPHYSIOLOGY, V7, P155, DOI 10.1111/j.1469-8986.1970.tb02222.x Bodfish J.W., 1998, REPETITIVE BEHAV SCA Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855 Boyd BA, 2009, RES AUTISM SPECT DIS, V3, P959, DOI 10.1016/j.rasd.2009.05.003 Boyd BA, 2010, AUTISM RES, V3, P78, DOI 10.1002/aur.124 Brandwein AB, 2013, CEREB CORTEX, V23, P1329, DOI 10.1093/cercor/bhs109 Cacioppo JT, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P1, DOI 10.2277/ 0521844711 Dawson G., 1989, AUTISM NATURE DIAGNO, P49 DesLauries A.M., 1969, YOUR CHILD IS ASLEEP Foss-Feig JH, 2010, EXP BRAIN RES, V203, P381, DOI 10.1007/s00221-010-2240-4 Gabriels RL, 2008, RES AUTISM SPECT DIS, V2, P660, DOI 10.1016/j.rasd.2008.02.002 Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Graham JW, 2009, ANNU REV PSYCHOL, V60, P549, DOI 10.1146/annurev.psych.58.110405.085530 Ham J, 2008, DEV PSYCHOBIOL, V50, P626, DOI 10.1002/dev.20317 Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724 HUTT C, 1964, NATURE, V204, P908, DOI 10.1038/204908a0 HUTT C, 1965, ANIM BEHAV, V13, P1, DOI 10.1016/0003-3472(65)90064-3 Kanner L, 1943, NERV CHILD, V2, P217 Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2 Lord C., 1999, AUTISM DIAGNOSTIC OB LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2012, AUTISM DIAGNOSTIC OB, V2 LOVAAS I, 1987, J APPL BEHAV ANAL, V20, P45, DOI 10.1901/jaba.1987.20-45 Lyndon S., 2013, J DEV PHYS DISABIL, V25, P149 Marco EJ, 2011, PEDIATR RES, V69, P48, DOI DOI 10.1203/PDR.0B013E3182130C54 McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59 McIntosh DN, 1999, DEV MED CHILD NEUROL, V41, P608, DOI 10.1017/S0012162299001267 Miller LJ, 2007, AM J OCCUP THER, V61, P135 Miller LJ, 1999, AM J MED GENET, V83, P268, DOI 10.1002/(SICI)1096-8628(19990402)83:4<268::AID-AJMG7>3.3.CO;2-B Mullen E, 1995, MULLEN SCALES EARLY Nunnally J. C., 1978, PSYCHOMETRIC THEORY OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225 Ozonoff S, 2008, AUTISM, V12, P457, DOI 10.1177/1362361308096402 PETERSON RA, 1994, J CONSUM RES, V21, P381, DOI 10.1086/209405 Rimland B., 1964, INFANTILE AUTISM Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x Rutter M., 2003, SOCIAL COMMUNICATION Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147 Schoen SA, 2008, RES AUTISM SPECT DIS, V2, P417, DOI 10.1016/j.rasd.2007.09.002 Schoen S.A., 2009, FRONTIERS INTEGRATIV, V3, P1, DOI DOI 10.3389/NEURO.07.029.2009 STEVENS S, 1984, J AUTISM DEV DISORD, V14, P245, DOI 10.1007/BF02409577 van Engeland H., 1984, J AUTISM DEV DISORD, V24, P99 VANENGELAND H, 1991, PSYCHIAT RES, V38, P27, DOI 10.1016/0165-1781(91)90050-Y Watson LR, 2011, J SPEECH LANG HEAR R, V54, P1562, DOI 10.1044/1092-4388(2011/10-0029) Woodard CR, 2012, RES AUTISM SPECT DIS, V6, P1234, DOI 10.1016/j.rasd.2012.03.012 NR 53 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 468 EP 480 DI 10.1002/aur.1382 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300006 PM 24788961 ER PT J AU Cook, R Brewer, R Shah, P Bird, G AF Cook, Richard Brewer, Rebecca Shah, Punit Bird, Geoffrey TI Intact Facial Adaptation in Autistic Adults SO AUTISM RESEARCH LA English DT Article DE autism; adaptation; aftereffects; facial identity; facial expressions ID FACE RECOGNITION; SPECTRUM DISORDERS; CHILDREN; IDENTITY; EMOTION; ALEXITHYMIA; EXPRESSIONS; PERCEPTION; FEATURES; 1ST AB Adaptation paradigms seek to bias subsequently viewed stimuli through prolonged exposure to an adapting stimulus, thereby giving rise to an aftereffect. Recent experiments have found that children with autism spectrum disorders (ASD) show reduced facial aftereffects, prompting some researchers to speculate that all individuals with ASD exhibit deficient facial adaptation. However, caution is required when generalizing findings from samples of children with ASD to the wider ASD population. The reduced facial aftereffects seen in child samples may instead reflect delayed or atypical developmental trajectories, whereby individuals with ASD are slower to develop adaptive mechanisms. In the present study, two experiments were conducted to determine whether high-functioning adults with ASD also show diminished aftereffects for facial identity and expression. In Experiment 1, using a procedure that minimized the contribution of low-level retinotopic adaptation, we observed substantial aftereffects comparable to those seen in matched controls, for both facial identity and expression. A similar pattern of results was seen in Experiment 2 using a revised procedure that increased the contribution of retinotopic adaptation to the facial aftereffects observed. That adults with autism can show robust facial aftereffects raises the possibility that group differences are seen only at particular points during development, and may not be a lifelong feature of the condition. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Cook, Richard] City Univ London, Dept Psychol, London EC1R OJD, England. [Brewer, Rebecca; Shah, Punit; Bird, Geoffrey] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England. [Shah, Punit] Univ London, Birkbeck Coll, Dept Psychol Sci, London, England. [Bird, Geoffrey] UCL, Inst Cognit Neurosci, London, England. RP Cook, R (reprint author), City Univ London, Dept Psychol, Whiskin St, London EC1R OJD, England. EM Richard.Cook.1@city.ac.uk CR Afraz SR, 2008, VISION RES, V48, P42, DOI 10.1016/j.visres.2007.10.028 American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 BLAKEMOR.C, 1969, J PHYSIOL-LONDON, V203, P237 Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357 CAMPBELL R, 1995, J EXP CHILD PSYCHOL, V59, P196, DOI 10.1006/jecp.1995.1009 CAREY S, 1977, SCIENCE, V195, P312, DOI 10.1126/science.831281 CAREY S, 1980, DEV PSYCHOL, V16, P257, DOI 10.1037/0012-1649.16.4.257 Clifford C. W. G., 2005, FITTING MIND WORLD A Cook R., 2011, J VISION, V11, P1, DOI DOI 10.1167/11.4.2 Cook R, 2013, PSYCHOL SCI, V24, P723, DOI 10.1177/0956797612463582 Bird G, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.61 Dennett HW, 2012, PSYCHOL SCI, V23, P1279, DOI 10.1177/0956797612446350 Ekman P., 1976, PICTURES FACIAL AFFE Ewing L, 2013, DEVELOPMENTAL SCI, V16, P116, DOI 10.1111/desc.12007 Fiorentini C, 2012, NEUROPSYCHOLOGIA, V50, P2926, DOI 10.1016/j.neuropsychologia.2012.08.019 Germine LT, 2011, COGNITION, V118, P201, DOI 10.1016/j.cognition.2010.11.002 Golarai G, 2007, NAT NEUROSCI, V10, P512, DOI 10.1038/nn1865 Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6 Johnston PJ, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00026 Johnston PJ, 2011, FRONT PSYCHOL, V2, P1, DOI DOI 10.3389/FPSYG.2011.00026 Kadosh KC, 2013, NEUROIMAGE, V69, P11, DOI 10.1016/j.neuroimage.2012.11.060 Kingdom F. A. A., 2009, PALAMEDES MATLAB ROU Leopold DA, 2001, NAT NEUROSCI, V4, P89, DOI 10.1038/82947 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02 Mondloch CJ, 2006, CHILD DEV, V77, P234, DOI 10.1111/j.1467-8624.2006.00867.x Mondloch CJ, 2002, PERCEPTION, V31, P553, DOI 10.1068/p3339 MOVSHON JA, 1979, NATURE, V278, P850, DOI 10.1038/278850a0 OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225 Pelli DG, 1997, SPATIAL VISION, V10, P437, DOI 10.1163/156856897X00366 Pellicano E, 2012, TRENDS COGN SCI, V16, P504, DOI 10.1016/j.tics.2012.08.009 Pellicano E, 2007, CURR BIOL, V17, P1508, DOI 10.1016/j.cub.2007.07.065 Rhodes G, 2006, VISION RES, V46, P2977, DOI 10.1016/j.visres.2006.03.002 Rhodes G, 2013, NEUROPSYCHOLOGIA, V51, P2702, DOI [10.1016/j.neuropsychologia.2013.08.016, 10.1016/Lneuropsychologia.2013.08.016] Rhodes G, 2010, VISION RES, V50, P963, DOI 10.1016/j.visres.2010.03.003 Rhodes G, 2007, VISION RES, V47, P2291, DOI 10.1016/j.visres.2007.05.012 Rutherford M., 2011, J AUTISM DEV DISORD, V42, P221 Rutherford MD, 2008, J EXP PSYCHOL HUMAN, V34, P27, DOI 10.1037/0096-1523.34.1.27 Scherf KS, 2007, DEVELOPMENTAL SCI, V10, pF15, DOI 10.1111/j.1467-7687.2007.00595.x Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001 Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005 Skinner AL, 2010, PSYCHOL SCI, V21, P1248, DOI 10.1177/0956797610380702 Susilo T, 2010, VISION RES, V50, P300, DOI 10.1016/j.visres.2009.11.016 Swettenham J, 1998, J CHILD PSYCHOL PSYC, V39, P747, DOI 10.1017/S0021963098002595 VALENTINE T, 1991, Q J EXP PSYCHOL-A, V43, P161 Webster MA, 2011, PHILOS T R SOC B, V366, P1702, DOI 10.1098/rstb.2010.0360 Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008 NR 48 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 481 EP 490 DI 10.1002/aur.1381 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300007 PM 24757172 ER PT J AU Hauth, I de Bruijn, YGE Staal, W Buitelaar, JK Rommelse, NN AF Hauth, Ingeborg de Bruijn, Yvette G. E. Staal, Wouter Buitelaar, Jan K. Rommelse, Nanda N. TI Testing the Extreme Male Brain Theory of Autism Spectrum Disorder in a Familial Design SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; extreme male brain theory; testosterone; 2D:4D; finger length; siblings; parents; empathizing; systemizing ID 4TH DIGIT LENGTH; FETAL TESTOSTERONE; SEX-DIFFERENCES; DIAGNOSTIC VALIDITY; RECEPTOR GENE; RATIO; CHILDREN; 2ND; TRAITS; HORMONE AB Autism Spectrum Disorder (ASD) may be an extreme manifestation of some male-typical traits in both neuroanatomy and cognition. Using the ratio of the second to fourth digit (2D:4D) and digit length as biomarkers of (pre- and postnatal) testosterone levels, examined was whether hypermasculinized digit ratios and/or lengths were familial traits in ASD and investigated their relation to sexually dimorphic cognitive abilities. 2D: 4D ratios and digit lengths of 216 children with ASD, 202 unaffected siblings, and 360 parents were compared with those of 174 control children and their 146 parents. Generalized Estimation Equations, Generalized Linear Models, and Linear Mixed Models were used to investigate parent-offspring relationships and group differences. In ASD probands and their relatives alike, digit length relative to overall height was significantly increased in comparison to controls. No significant group differences were found between affected and unaffected subjects, or between males and females. Additionally, 2D: 4D ratios increased with age. No (consistent) associations were found between 2D: 4D ratio or digit lengths and systemizing and empathizing skills. The findings emphasize the role of familially based elevated pre- and postnatal testosterone levels in the liability for ASD, but challenge the use of 2D: 4D ratio as a proxy of prenatal testosterone exposure solely. Given that many genes influence digit length, the exact mechanisms underlying a familial predisposition toward increased digit length in ASD are as yet unknown and needs to be explored in future studies. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Hauth, Ingeborg; Staal, Wouter; Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain, Cognit & Behav Dept Cognit Neurosci, NL-6525 GC Nijmegen, Netherlands. [de Bruijn, Yvette G. E.; Staal, Wouter; Buitelaar, Jan K.; Rommelse, Nanda N.] Child & Adolescent Psychiat Univ Ctr, Karakter, Nijmegen, Netherlands. [Rommelse, Nanda N.] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain, Cognit & Behav Dept Psychiat, NL-6525 GC Nijmegen, Netherlands. RP Rommelse, NN (reprint author), Radboud Univ Nijmegen, Med Ctr, Reinier Postlaan 12, NL-6525 GC Nijmegen, Netherlands. EM n.lambregts-rommelse@psy.umcn.nl CR Allaway HC, 2009, AM J HUM BIOL, V21, P365, DOI 10.1002/ajhb.20892 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Auyeung B, 2012, MOL AUTISM, V3, DOI 10.1186/2040-2392-3-17 Auyeung B, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-11 Baron-Cohen S, 2010, PROG BRAIN RES, V186, P167, DOI 10.1016/B978-0-444-53630-3.00011-7 Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6 Baron-Cohen S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001081 Bejerot S, 2012, BRIT J PSYCHIAT, V201, P116, DOI 10.1192/bjp.bp.111.097899 Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444 Brown WM, 2002, HORM BEHAV, V42, P380, DOI 10.1006/hbeh.2002.1830 Chapman E, 2006, SOC NEUROSCI, V1, P135, DOI 10.1080/17470910600992239 Cherney ID, 2010, PERCEPT MOTOR SKILL, V110, P809, DOI 10.2466/PMS.110.3.809-824 COLLAER ML, 1995, PSYCHOL BULL, V118, P55, DOI 10.1037//0033-2909.118.1.55 De Sonneville L. M. J., 2005, TIJDSCHRIFT NEUROPSY, P27 De Sonneville LMJ, 2002, J CLIN EXP NEUROPSYC, V24, P200, DOI 10.1076/jcen.24.2.200.989 Forstmeier W, 2010, P ROY SOC B-BIOL SCI, V277, P3353, DOI 10.1098/rspb.2010.1007 Geary D., 2002, SEXUAL SELECTION SEX Geier DA, 2007, NEUROENDOCRINOL LETT, V28, P565 Goodman JDT, 1997, J BIOSOC SCI, V29, P181, DOI 10.1017/S0021932097001818 Honekopp J, 2007, PSYCHONEUROENDOCRINO, V32, P313, DOI 10.1016/j.psyneuen.2007.01.007 Ingudomnuku E, 2007, HORM BEHAV, V51, P597, DOI 10.1016/j.yhbeh.2007.02.001 Knickmeyer R, 2005, J CHILD PSYCHOL PSYC, V46, P198, DOI 10.1111/j.1469-7610.2004.00349.x Le Couteur A., 2003, AUTISM DIAGNOSTIC IN Lippa RA, 2006, BIOL PSYCHOL, V71, P116, DOI 10.1016/j.biopsycho.2005.02.004 Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34 Lundstrom S, 2012, ARCH GEN PSYCHIAT, V69, P46, DOI 10.1001/archgenpsychiatry.2011.144 Lutchmaya S, 2004, EARLY HUM DEV, V77, P23, DOI 10.1016/j.earlhumdev.2003.12.002 Lutchmaya S, 2002, INFANT BEHAV DEV, V24, P418 Manning JT, 2002, DIGIT RATIO POINTER Manning JT, 2003, EVOL HUM BEHAV, V24, P399, DOI 10.1016/S1090-5138(03)00052-7 Manning JT, 2001, DEV MED CHILD NEUROL, V43, P160, DOI 10.1017/S0012162201000317 Manning JT, 1998, HUM REPROD, V13, P3000, DOI 10.1093/humrep/13.11.3000 McIntyre MH, 2006, AM J PHYS ANTHROPOL, V129, P143, DOI 10.1002/ajpa.20240 McIntyre MH, 2005, P ROY SOC B-BIOL SCI, V272, P1473, DOI 10.1098/rspd.2005.3100 Milne E, 2006, J AUTISM DEV DISORD, V36, P225, DOI 10.1007/s10803-005-0052-3 Noipayak Pongsak, 2009, Journal of the Medical Association of Thailand, V92, P1040 Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009 Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026 Teatero ML, 2013, J AUTISM DEV DISORD, V43, P2664, DOI 10.1007/s10803-013-1819-6 Tordjman S, 1997, AM J PSYCHIAT, V154, P1626 Ventura T, 2013, EARLY HUM DEV, V89, P107, DOI 10.1016/j.earlhumdev.2012.08.009 Wallen K, 2009, ENDOCRINOLOGY, V150, P4819, DOI 10.1210/en.2009-0986 Wechsler D., 1989, WECHSLER PRESCHOOL P Woodbury-Smith MR, 2005, J AUTISM DEV DISORD, V35, P331, DOI 10.1007/s10803-005-3300-7 NR 44 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 491 EP 500 DI 10.1002/aur.1384 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300008 PM 24777834 ER PT J AU Kang, V Wagner, GC Ming, X AF Kang, Victor Wagner, George C. Ming, Xue TI Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; gastrointestinal disorders; comorbid disorders; endoscopy; colonoscopy; inflammation ID SYMPTOMS; ABNORMALITIES; POPULATION; PREVALENCE; DISEASE; ASDS AB Gastrointestinal (GI) dysfunctions are frequently reported by parents of children with autism spectrum disorders (ASD) and have been recently recognized as a comorbid condition. However, the clinical significance of these GI dysfunctions remains to be delineated. This study describes the clinical characteristics, associated comorbid disorders, and endoscopic and colonoscopic evaluation of GI dysfunction in a cohort of 164 children with ASD evaluated at a pediatric neurology practice. Symptoms of GI dysfunction were prevalent: 49% of the children reported one or more chronic GI complaints, 22% exhibited diarrhea, 26% suffered from constipation. Furthermore 13% of the parents reported their children to suffer from bloating and/or being gassy and while 10% of the parents reported vomiting or gastroesophageal reflux problems. Similar rates of GI symptoms were reported among pre-school and school-aged children. Inflammation of the gut was found in 6 of the 12 subjects who underwent endoscopic and colonoscopic evaluations, however clinical symptoms did not predict the results of the evaluation. GI dysfunction was significantly associated with sleep disorders and food intolerance, but not with irritability or aggressiveness. In summary, GI dysfunction was prevalent in this cohort of children with ASD, observations consistent with the reports of parents and other clinicians. We conclude that the GI dysfunction in ASD requires proper evaluation and treatment. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Kang, Victor] Johns Hopkin Univ, Sch Arts & Sci, Baltimore, MD USA. [Wagner, George C.] Rutgers State Univ, Dept Psychol, New Brunswick, NJ 08903 USA. [Ming, Xue] Rutgers State Univ, New Jersey Med Sch, Dept Neurosci, Newark, NJ 07103 USA. [Ming, Xue] JFK Med Ctr, New Jersey Neurosci Inst, Sleep Med Ctr, Edison, NJ USA. RP Ming, X (reprint author), Rutgers State Univ, New Jersey Med Sch, 90 Bergen St,DOC 8100, Newark, NJ 07103 USA. EM mingxu@njms.rutgers.edu FU Knights of Columbus, East Hanover, NJ FX The authors wish to acknowledge the cooperation of all the parents and guardians of the participating subjects with ASD and the generous support from Knights of Columbus, East Hanover, NJ. All authors declare no conflict of interest in this study and approve this final version of the revised manuscript. CR Black C, 2002, BRIT MED J, V325, P419, DOI 10.1136/bmj.325.7361.419 Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C Buie T, 2010, PEDIATRICS, V125, pS19, DOI 10.1542/peds.2009-1878D Coury Daniel L, 2012, Pediatrics, V130 Suppl 2, pS160, DOI 10.1542/peds.2012-0900N Harris C, 2012, COMPLEMENT THER MED, V20, P437, DOI 10.1016/j.ctim.2012.08.004 Horvath K, 1999, J PEDIATR-US, V135, P559, DOI 10.1016/S0022-3476(99)70052-1 Horvath K, 2002, CURR OPIN PEDIATR, V14, P583, DOI 10.1097/01.MOP.0000030221.71203.46 Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933 Jyonouchi H, 2011, J NEUROIMMUNOL, V238, P73, DOI 10.1016/j.jneuroim.2011.07.001 Ming X, 2012, J PROTEOME RES, V11, P5856, DOI 10.1021/pr300910n Molloy CA, 2003, AUTISM, V7, P165, DOI 10.1177/1362361303007002004 Nikolov RN, 2009, J AUTISM DEV DISORD, V39, P405, DOI 10.1007/s10803-008-0637-8 Parracho HMRT, 2005, J MED MICROBIOL, V54, P987, DOI 10.1099/jmm.0.46101-0 Reichelt KL, 2009, ANN CLIN PSYCHIATRY, V21, P205 Smith RA, 2009, AUTISM, V13, P343, DOI 10.1177/1362361309106418 Taylor B, 2002, BRIT MED J, V324, P393, DOI 10.1136/bmj.324.7334.393 Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011 Wang LW, 2011, J DEV BEHAV PEDIATR, V32, P351, DOI 10.1097/DBP.0b013e31821bd06a Xue Ming, 2008, J Child Neurol, V23, P6 NR 19 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 501 EP 506 DI 10.1002/aur.1386 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300009 PM 24753336 ER PT J AU Segers, M Rawana, J AF Segers, Magali Rawana, Jennine TI What Do We Know About Suicidality in Autism Spectrum Disorders? A Systematic Review SO AUTISM RESEARCH LA English DT Review DE autism spectrum disorders; suicide; suicidality; prevalence; risk factors; protective factors ID PERVASIVE DEVELOPMENTAL DISORDERS; HIGH-FUNCTIONING AUTISM; DIAGNOSTIC INTERVIEW; SELF-HARM; ASPERGERS-DISORDER; ADOLESCENTS; CHILDREN; RISK; DEPRESSION; QUOTIENT AB Suicidality is a common and concerning issue across development, and there is a plethora of research on this topic among typically developing children and youth. Very little is known, however, about the nature of suicidality among individuals with autism spectrum disorders (ASDs). The purpose of the current study was to undertake a systematic literature review to assess the current state of the research literature to examine the prevalence of suicidality among individuals with ASD, related demographic and clinical profiles, and associated risk and protective factors. A literature search using key terms related to suicidality and ASD yielded 10 topical studies that were evaluated for the study objectives. Suicidality was present in 10.9-50% of the ASD samples identified in the systematic review. Further, several large-scale studies found that individuals with ASD comprised 7.3-15% of suicidal populations, a substantial subgroup. Risk factors were identified and included peer victimization, behavioral problems, being Black or Hispanic, being male, lower socioeconomic status, and lower level of education. Only one study reported on protective factors, and this is identified as a significant gap in the literature. Several methodological weaknesses were present in the current literature, such as lack of appropriate comparison groups and little to no use of empirically validated measures for ASD diagnosis and suicide assessment. Additional research is necessary to understand better how this unique population experiences and expresses suicidal tendencies. Recommendations for future research are discussed. (C) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Segers, Magali; Rawana, Jennine] York Univ, Dept Psychol, Toronto, ON M3J 1P3, Canada. RP Rawana, J (reprint author), York Univ, 131 Behav Sci Bldg,4700 Keele St, Toronto, ON M3J 1P3, Canada. EM rawana@yorku.ca CR Allison C, 2012, J AM ACAD CHILD PSY, V51, P202, DOI 10.1016/j.jaac.2011.11.003 American Psychiatric Association, 2013, DIAGN STAT MAN MENT Arick J. R., 2003, KRUG ASPERGERS DISOR Arnett J. J., 2007, HDB SOCIALIZATION TH, P208, DOI DOI 10.1093/ACPROF:OSO/9780199757176.001.0001 Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z Balfe Myles, 2010, BMC Res Notes, V3, P300, DOI 10.1186/1756-0500-3-300 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6 Bayley N., 1969, BAYLEY SCALES INFANT Beck AT, 1987, BDI BECK DEPRESSION Bergen H, 2012, J AFFECT DISORDERS, V136, P526, DOI 10.1016/j.jad.2011.10.036 Bryan CJ, 2006, J CLIN PSYCHOL, V62, P185, DOI 10.1002/jclp.20222 Campbell JM, 2005, J AUTISM DEV DISORD, V35, P25, DOI 10.1007/s10803-004-1028-4 Carpenter P., 2012, ADV MENTAL HLTH INTE, V6, P121, DOI DOI 10.1108/20441281211227184 CDC, 2012, MMWR SURVEILL SUMM, V61, P1 Charman T, 2013, CHILD ADOL MENT H-UK, V18, P52, DOI 10.1111/j.1475-3588.2012.00664.x Cheon J.W., 2008, ADV SOCIAL WORK, V9, P176 Constantino JN, 2002, SOCIAL RESPONSIVENES de Bildt A, 2004, J AUTISM DEV DISORD, V34, P129 Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493 Fombonne E, 2005, J APPL RES INTELLECT, V18, P281, DOI 10.1111/j.1468-3148.2005.00266.x Frith U., 1989, AUTISM EXPLAINING EN Ghaziuddin M, 1998, J AUTISM DEV DISORD, V28, P111, DOI 10.1023/A:1026036514719 Gillberg C, 2001, AUTISM, V5, P57, DOI 10.1177/1362361301005001006 Gutierrez PM, 2006, SUICIDE LIFE-THREAT, V36, P129, DOI 10.1521/suli.2006.36.2.129 Gutierrez PM, 2001, J PERS ASSESS, V77, P475, DOI 10.1207/S15327752JPA7703_08 Hansson SL, 2005, BRIT J PSYCHIAT, V187, P262, DOI 10.1192/bjp.187.3.262 Hardan A, 1999, RES DEV DISABIL, V20, P287, DOI 10.1016/S0891-4222(99)00010-4 Hare D. J., 1997, AUTISM, V1, P215, DOI [10.1177/1362361397012007, DOI 10.1177/1362361397012007] Hawton K, 2013, J AFFECT DISORDERS, V147, P17, DOI 10.1016/j.jad.2013.01.004 Hawton K, 2009, LANCET, V373, P1372, DOI 10.1016/S0140-6736(09)60372-X Hawton K, 2012, LANCET, V379, P2373, DOI 10.1016/S0140-6736(12)60322-5 Hedley D, 2006, AUTISM, V10, P139, DOI 10.1177/1362361306062020 Kasper S, 1996, INT CLIN PSYCHOPHARM, V11, P71, DOI 10.1097/00004850-199611020-00001 Kato K, 2013, GEN HOSP PSYCHIAT, V35, P50, DOI 10.1016/j.genhosppsych.2012.09.006 Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021 Khouzam HR, 2004, COMPR PSYCHIAT, V45, P184, DOI 10.1016/j.comppsych.2004.03.004 Kurita H, 2005, PSYCHIAT CLIN NEUROS, V59, P490, DOI 10.1111/j.1440-1819.2005.01403.x Lindgren S.D., 1987, ADV BEHAVIORAL ASSES, V3, P57 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Mayes S. D., 2012, CHECKLIST AUTISM SPE Mayes SD, 2013, RES AUTISM SPECT DIS, V7, P109, DOI 10.1016/j.rasd.2012.07.009 McDonald KL, 2010, J YOUTH ADOLESCENCE, V39, P563, DOI 10.1007/s10964-010-9519-4 Mikami K, 2009, GEN HOSP PSYCHIAT, V31, P163, DOI 10.1016/j.genhosppsych.2008.12.003 Mukaddes NM, 2010, WORLD J BIOL PSYCHIA, V11, P486, DOI [10.1080/15622970902789130, 10.3109/15622970902789130] Munesue T, 2008, J AFFECT DISORDERS, V111, P170, DOI 10.1016/j.jad.2008.02.015 Nimeus A, 2000, EUR PSYCHIAT, V15, P416, DOI 10.1016/S0924-9338(00)00512-5 Norrish JM, 2009, AUST PSYCHOL, V44, P270, DOI 10.1080/00050060902914103 Osman A, 1998, J CLIN PSYCHOL, V54, P1063, DOI 10.1002/(SICI)1097-4679(199812)54:8<1063::AID-JCLP6>3.0.CO;2-Z Ouellette-Kuntz H, 2012, CHRON DIS INJ CAN, V32, P84 Psychological Corporation, 1999, WECHSLER ABBREVIATED Raja Michele, 2011, Clin Pract Epidemiol Ment Health, V7, P97, DOI 10.2174/1745017901107010097 RAO U, 1993, J AM ACAD CHILD PSY, V32, P21, DOI 10.1097/00004583-199301000-00004 REYNOLDS WM, 1991, J PERS ASSESS, V56, P289, DOI 10.1207/s15327752jpa5602_9 Reynolds W. M., 2002, REYNOLDS ADOLESCENT Reynolds W. M., 1987, SUICIDAL IDEATION QU Rivet TT, 2011, RES AUTISM SPECT DIS, V5, P957, DOI 10.1016/j.rasd.2010.12.003 Rutter M., 2003, AUTISM DIAGNOSTIC IN Rutter M., 2003, SOCIAL COMMUNICATION Ryden G., 2008, CLIN NEUROPSYCHIATRY, V5, P22 Saltz A., 1990, AM J PSYCHIAT, V147, P190 Schmid AM, 2011, AM J NURS, V111, P34, DOI 10.1097/01.NAJ.0000405060.13022.b7 Shtayermman Oren, 2007, Issues Compr Pediatr Nurs, V30, P87, DOI 10.1080/01460860701525089 Shtayermman O., 2008, J HUMAN BEHAV SOCIAL, V18, P301, DOI 10.1080/10911350802427548 Silverman WK, 1996, ANXIETY DISORDERS IN, V1 Skegg K, 2005, LANCET, V366, P1471, DOI 10.1016/S0140-6736(05)67600-3 Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008 Spencer L, 2011, AM J PSYCHIAT, V168, P890, DOI 10.1176/appi.ajp.2011.10091261 Storch EA, 2013, J AUTISM DEV DISORD, V43, P2450, DOI 10.1007/s10803-013-1795-x Strang JF, 2012, RES AUTISM SPECT DIS, V6, P406, DOI 10.1016/j.rasd.2011.06.015 Thorndike RL, 1986, STANFORD BINET INTEL Wechsler D, 1974, WECHSLER INTELLIGENC Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd Wechsler D, 1981, WECHSLER ADULT INTEL Wechsler D., 2003, WECHSLER INTELLECTUA Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd Weiss J., 2002, J DEV DISABILITIES, V9, P127 White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003 Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023 NR 80 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2014 VL 7 IS 4 BP 507 EP 521 DI 10.1002/aur.1375 PG 15 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AN5VJ UT WOS:000340659300010 PM 24798640 ER PT J AU McClintic, AM King, BH Webb, SJ Mourad, PD AF McClintic, Abbi M. King, Bryan H. Webb, Sara J. Mourad, Pierre D. TI Mice Exposed to Diagnostic Ultrasound In Utero Are Less Social and More Active in Social Situations Relative to Controls SO AUTISM RESEARCH LA English DT Article DE diagnostic ultrasound; mouse social behavior; autistic-like behavior; risk factor ID AUTISM SPECTRUM DISORDERS; RANDOMIZED CONTROLLED-TRIAL; BEHAVIORAL TASKS RELEVANT; PRENATAL ULTRASOUND; FETAL PERIOD; FOLLOW-UP; MOUSE; RISK; AGE; ASSOCIATION AB Clinical use of diagnostic ultrasound imaging during pregnancy has a long history of safety and diagnostic utility, as supported by numerous human case reports and epidemiological studies. However, there exist in vivo studies linking large but clinically relevant doses of ultrasound applied to mouse fetuses in utero to altered learning, memory, and neuroanatomy of those mice. Also, there exists a well-documented significant increase in the likelihood of non-right-handedness in boys exposed to diagnostic ultrasound in utero, potentially relevant given the increased prevalence of autism in males, and reports of excess non-right-handedness in this population. Motivated by these observations, we applied 30minutes of diagnostic ultrasound to pregnant mice at embryonic day 14.5 and assayed the social behavior of their male pups 3 weeks after their birth. The ultrasound-exposed pups were significantly (P<0.01) less interested in social interaction than sham-exposed pups in a three-chamber sociability test. In addition, they demonstrated significantly (P<0.05) more activity relative to the sham-exposed pups, but only in the presence of an unfamiliar mouse. These results suggest that fetal exposure to diagnostic ultrasound applied in utero can alter typical social behaviors in young mice that may be relevant for autism. There exist meaningful differences between the exposure of diagnostic ultrasound to mice versus humans that require further exploration before this work can usefully inform clinical practice. Future work should address these differences as well as clarify the extent, mechanisms, and functional effects of diagnostic ultrasound's interaction with the developing brain. Autism Res 2014, 7: 295-304. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [McClintic, Abbi M.; Mourad, Pierre D.] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA. [King, Bryan H.] Seattle Childrens Hosp, Seattle Childrens Autism Ctr, Seattle, WA USA. [King, Bryan H.] Seattle Childrens Hosp, Seattle, WA USA. [King, Bryan H.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Webb, Sara J.] Univ Washington, Seattle, WA 98195 USA. [Webb, Sara J.] Univ Washington, Autism Ctr, Seattle, WA 98195 USA. [Webb, Sara J.] Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA. [Mourad, Pierre D.] Univ Washington, Appl Phys Lab, Dept Engn & Math, Seattle, WA 98195 USA. [Mourad, Pierre D.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA. RP Mourad, PD (reprint author), Univ Washington, Dept Neurol Surg, Box 356470, Seattle, WA 98195 USA. EM pierre@apl.washington.edu FU National Institute of Child Health and Human Development [P30 HD002274] FX We thank the Mouse Behavior Core in the Center for Human Development and Disability at the University of Washington, supported by grant P30 HD002274 from the National Institute of Child Health and Human Development, for the resources to perform the behavioral studies. We also thank Dr. Sean Murphy and Dr. Toby Cole, who manage the Mouse Behavior Core for their considerable assistance. CR Abramowicz JS, 2007, ULTRASOUND OBST GYN, V29, P363, DOI 10.1002/uog.3983 Abramowicz JS, 2012, J ULTRAS MED, V31, P1261 Ang ESBC, 2006, P NATL ACAD SCI USA, V103, P12903, DOI 10.1073/pnas.0605294103 Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILLANCE SU, V61, P1 Center for Devices and Radiological Health, 1997, INF MAN SEEK MARK CL Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039 Dane S, 2007, INT J DEV NEUROSCI, V25, P223, DOI 10.1016/j.ijdevneu.2007.03.005 DEVI PU, 1995, RADIAT RES, V141, P314, DOI 10.2307/3579009 Fatemi M, 2001, J ULTRAS MED, V20, P883 FDA, 2013, AV FET KEEPS IM HEAR Gibbs V., 2009, ULTRASOUND PHYS TECH, P94 Grether JK, 2010, J AUTISM DEV DISORD, V40, P238, DOI 10.1007/s10803-009-0859-4 Hinoue A, 2001, DEV BRAIN RES, V132, P59, DOI 10.1016/S0165-3806(01)00295-4 Interagency Autism Coordinating Committee (IACC), 2012, IACC STRAT PLAN AUT JENSH RP, 1995, P SOC EXP BIOL MED, V210, P171 Kalil K, 2011, FRONT NEUROANAT, V5, DOI 10.3389/fnana.2011.00062 Kaufman M. H., 1999, ANATOMICAL BASIS MOU, P171, DOI 10.1016/B978-012402060-3/50037-4 Krakowiak P, 2012, PEDIATRICS, V129, pE1121, DOI 10.1542/peds.2011-2583 Lampi KM, 2013, J AUTISM DEV DISORD, V43, P2526, DOI 10.1007/s10803-013-1801-3 Lyall K, 2012, AUTISM RES, V5, P21, DOI 10.1002/aur.228 Matson JL, 2013, RES DEV DISABIL, V34, P2475, DOI 10.1016/j.ridd.2013.05.021 Mourad P. D., 2012, ULTRASONIC TRANSDUCE, P454 Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030 Rados Carol, 2004, FDA Consum, V38, P12 Salvesen Kjell A, 2002, Eur J Ultrasound, V15, P165, DOI 10.1016/S0929-8266(02)00038-1 Salvesen KA, 2007, PROG BIOPHYS MOL BIO, V93, P295, DOI 10.1016/j.pbiomolbio.2006.07.013 Sandin S, 2012, J AM ACAD CHILD PSY, V51, P477, DOI 10.1016/j.jaac.2012.02.018 SOPER HV, 1986, J AUTISM DEV DISORD, V16, P155, DOI 10.1007/BF01531727 Stalberg K, 2009, ULTRASOUND OBST GYN, V34, P297, DOI 10.1002/uog.7332 STEWART HD, 1985, J CLIN ULTRASOUND, V13, P167, DOI 10.1002/jcu.1870130304 Stoch YK, 2012, J AUTISM DEV DISORD, V42, P2693, DOI 10.1007/s10803-012-1526-8 Suresh R, 2008, ANN ANAT, V190, P37, DOI 10.1016/j.aanat.2007.04.008 Suresh R, 2002, LIFE SCI, V71, P339, DOI 10.1016/S0024-3205(02)01642-9 ter Haar GR, 2013, ULTRASOUND MED BIOL, V39, P374, DOI 10.1016/j.ultrasmedbio.2012.11.024 Tufail Y, 2010, NEURON, V66, P681, DOI 10.1016/j.neuron.2010.05.008 Vorhees C. V., 1986, HDB BEHAV TERATOLOGY, P23 Whitworth M., 2010, COCHRANE DB SYST REV, V4, P1 Williams EL, 2010, MED HYPOTHESES, V75, P53, DOI 10.1016/j.mehy.2010.01.027 Williams EL, 2013, TRANSL NEUROSCI, V4, P81, DOI 10.2478/s13380-013-0112-7 Yang M., 2011, CURRENT PROTOCOL S56, V56 Yang M, 2009, EUR J NEUROSCI, V29, P1663, DOI 10.1111/j.1460-9568.2009.06714.x NR 41 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD JUN PY 2014 VL 7 IS 3 BP 295 EP 304 DI 10.1002/aur.1349 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AJ9KD UT WOS:000338027900001 PM 24249575 ER PT J AU Dalton, N Chandler, S Turner, C Charman, T Pickles, A Loucas, T Simonoff, E Sullivan, P Baird, G AF Dalton, Neil Chandler, Susie Turner, Charles Charman, Tony Pickles, Andrew Loucas, Tom Simonoff, Emily Sullivan, Peter Baird, Gillian TI Gut Permeability in Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism; autism spectrum disorders; gut permeability; lactulose; mannitol ratio ID INTESTINAL PERMEABILITY; GASTROINTESTINAL SYMPTOMS; CHILDREN; DISEASE; INDIVIDUALS; ASSOCIATION; PREVALENCE; LACTULOSE; MANNITOL; FAMILIES AB Objective To test whether gut permeability is increased in autism spectrum disorders (ASD) by evaluating gut permeability in a population-derived cohort of children with ASD compared with age- and intelligence quotient-matched controls without ASD but with special educational needs (SEN). Patients and Methods One hundred thirty-three children aged 10-14 years, 103 with ASD and 30 with SEN, were given an oral test dose of mannitol and lactulose and urine collected for 6hr. Gut permeability was assessed by measuring the urine lactulose/mannitol (L/M) recovery ratio by electrospray mass spectrometry-mass spectrometry. The ASD group was subcategorized for comparison into those without (n=83) and with (n=20) regression. Results There was no significant difference in L/M recovery ratio (mean (95% confidence interval)) between the groups with ASD: 0.015 (0.013-0.018), and SEN: 0.014 (0.009-0.019), nor in lactulose, mannitol, or creatinine recovery. No significant differences were observed in any parameter for the regressed versus non-regressed ASD groups. Results were consistent with previously published normal ranges. Eleven children (9/103=8.7% ASD and 2/30=6.7% SEN) had L/M recovery ratio >0.03 (the accepted normal range cut-off), of whom two (one ASD and one SEN) had more definitely pathological L/M recovery ratios >0.04. Conclusion There is no statistically significant group difference in small intestine permeability in a population cohort-derived group of children with ASD compared with a control group with SEN. Of the two children (one ASD and one SEN) with an L/M recovery ratio of >0.04, one had undiagnosed asymptomatic celiac disease (ASD) and the other (SEN) past extensive surgery for gastroschisis. Autism Res 2014, 7: 305-313. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Dalton, Neil; Turner, Charles] Evelina Childrens Hosp, WellChild Lab, London, England. [Dalton, Neil; Turner, Charles] Kings Coll London, London WC2R 2LS, England. [Chandler, Susie; Baird, Gillian] Guys & St Thomas NHS Fdn Trust, Newcomen Ctr, London, England. [Chandler, Susie; Charman, Tony; Pickles, Andrew; Simonoff, Emily; Baird, Gillian] Kings Coll London, Inst Psychiat, London WC2R 2LS, England. [Loucas, Tom] Univ Reading, Sch Psychol & Clin Language Sci, Reading RG6 2AH, Berks, England. [Sullivan, Peter] Univ Oxford, Dept Paediat, Oxford Childrens Hosp, Oxford OX1 2JD, England. RP Baird, G (reprint author), St Thomas Hosp, Childrens Neurosci Ctr, Block D,Westminster Bridge Rd, London SE1 7EH, England. EM gillian.baird@gstt.nhs.uk RI Pickles, Andrew/A-9625-2011 OI Pickles, Andrew/0000-0003-1283-0346 FU Wellcome Trust [GR045093MA]; Department of Health [039/0026]; Remedi [22] FX The study was funded as follows:Grant sponsor: Wellcome Trust; Grant number: GR045093MA; Grant sponsor: the Department of Health; Grant number: 039/0026; Grant sponsor: Remedi; Grant number: 22 CR Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Baird G, 2008, J AUTISM DEV DISORD, V38, P1827, DOI 10.1007/s10803-008-0571-9 BJARNASON I, 1995, GASTROENTEROLOGY, V108, P1566, DOI 10.1016/0016-5085(95)90708-4 Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C Buie T, 2010, PEDIATRICS, V125, pS19, DOI 10.1542/peds.2009-1878D Campbell DB, 2009, PEDIATRICS, V123, P1018, DOI 10.1542/peds.2008-0819 Chandler S, 2013, J AUTISM DEV DISORD, V43, P2737, DOI 10.1007/s10803-013-1768-0 de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5 DEufemia P, 1996, ACTA PAEDIATR, V85, P1076, DOI 10.1111/j.1651-2227.1996.tb14220.x Erickson CA, 2005, J AUTISM DEV DISORD, V35, P713, DOI 10.1007/s10803-005-0019-4 Gorrindo P, 2012, AUTISM RES, V5, P101, DOI 10.1002/aur.237 Halme L, 2000, SCAND J CLIN LAB INV, V60, P695, DOI 10.1080/00365510050216420 Horvath Karoly, 2002, Curr Gastroenterol Rep, V4, P251, DOI 10.1007/s11894-002-0071-6 Horvath Karoly, 2000, JPGN, V31, pS30 Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933 Knivsberg AM, 2002, NUTR NEUROSCI, V5, P251, DOI 10.1080/10281450290028945 LECOUTEUR A, 1988, J AUTISM DEV DISORD, V18, P181 Levy SE, 2008, CHILD ADOL PSYCH CL, V17, P803, DOI 10.1016/j.chc.2008.06.004 Liu Z, 2005, ACTA PAEDIATR, V94, P386, DOI 10.1080/08035250410023304 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Marsilio R, 1998, CLIN CHEM, V44, P1685 Millward C, 2004, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD003498.PUB2 PANKSEPP J, 1979, TRENDS NEUROSCI, V2, P174, DOI 10.1016/0166-2236(79)90071-7 Raven JC, 1990, COLOURED PROGR MATRI Raven John C., 1990, STANDARD PROGR MATRI REICHELT K-L, 1990, Journal of Applied Nutrition, V42, P1 Reichelt K L, 1981, Adv Biochem Psychopharmacol, V28, P627 Robertson MA, 2008, J AUTISM DEV DISORD, V38, P1066, DOI 10.1007/s10803-007-0482-1 Rutter M., 2003, SCQ SOCIAL COMMUNICA Shattock Paul, 2002, Expert Opin Ther Targets, V6, P175 Shattock Paul, 1991, Brain Dysfunction, V4, P323 Smith RA, 2009, AUTISM, V13, P343, DOI 10.1177/1362361309106418 Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011 Vickery S, 2006, NEPHROL DIAL TRANSPL, V21, P2439, DOI 10.1093/ndt/gfl249 Wang LW, 2011, J DEV BEHAV PEDIATR, V32, P351, DOI 10.1097/DBP.0b013e31821bd06a Wechsler D., 1992, WECHSLER INTELLIGENC WYATT J, 1993, LANCET, V341, P1437, DOI 10.1016/0140-6736(93)90882-H NR 38 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD JUN PY 2014 VL 7 IS 3 BP 305 EP 313 DI 10.1002/aur.1350 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AJ9KD UT WOS:000338027900002 PM 24339339 ER PT J AU Stockbridge, MD Happe, FGE White, SJ AF Stockbridge, Melissa D. Happe, Francesca G. E. White, Sarah J. TI Impaired Comprehension of Alternating Syntactic Constructions in Autism SO AUTISM RESEARCH LA English DT Article DE autism; language development; syntax; dative alternation ID SPECTRUM DISORDERS; DATIVE ALTERNATION; LANGUAGE PROFILES; COGNITIVE-STYLE; CHILDREN; ENGLISH AB Individuals on the higher-functioning end of the autism spectrum have significant impairments in communication. Language delay can occur, particularly in syntactic or structural linguistic knowledge. However, classically observed semantic deficits generally overshadow these structural deficits. This research examined the potential effects on comprehension of dative expressions that exhibited syntactic alternation versus those that were restricted, whether in syntactic construction or through marked semantic differences in construction. Children with autism and matched neurotypical control participants were presented with a sentence battery of dative statements representing these variations in construction and were asked to display basic comprehension of the sentence meaning by identifying the recipient, or indirect object, of the dative verb. Construction, restriction, and semantic differentiation variables were analyzed for potential effects on the rate of accurate comprehension. Both groups performed with greater accuracy when dative expressions used a prepositional phrase than when the dative action was expressed in the syntax. The autism group performed more poorly when the dative expression could syntactically alternate than when it was restricted. These effects improve our knowledge of how children with autism understand alternating grammatical constructions. Autism Res 2014, 7: 314-321. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Stockbridge, Melissa D.; White, Sarah J.] UCL, Inst Cognit Neurosci, London WC1N 3AR, England. [Happe, Francesca G. E.] Kings Coll London, Inst Psychiat, London WC2R 2LS, England. RP White, SJ (reprint author), UCL, Inst Cognit Neurosci, 17 Queen Sq, London WC1N 3AR, England. EM s.white@ucl.ac.uk RI White, Sarah/C-4084-2008 OI White, Sarah/0000-0001-6946-9155 FU British Academy Fellowship [PDF/2009/213] FX Grant sponsors: This work was supported by a British Academy Fellowship PDF/2009/213 to S. J. W. CR Anderson J. M., 1971, GRAMMAR CASE Baron-Cohen S, 1999, DEV COGN NEUROSCI, P401 Bartlett SC, 2005, CLIN LINGUIST PHONET, V19, P203, DOI 10.1080/02699200410001698634 Brysbaert M, 2009, BEHAV RES METHODS, V41, P977, DOI 10.3758/BRM.41.4.977 Caplan D., 1988, DISORDERS SYNTACTIC Chomsky N., 1965, ASPECTS THEORY SYNTA Conwell E, 2007, COGNITION, V103, P163, DOI 10.1016/j.cognition.2006.03.003 DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777 Demuth K, 2005, LANGUAGE, V81, P421, DOI 10.1353/lan.2005.0056 Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd Eigsti IM, 2007, J AUTISM DEV DISORD, V37, P1007, DOI 10.1007/s10803-006-0239-2 Eigsti IM, 2009, J CHILD LANG, V36, P999, DOI 10.1017/S0305000909009362 FINE J, 1991, J CHILD PSYCHOL PSYC, V32, P771, DOI 10.1111/j.1469-7610.1991.tb01901.x Frith U., 1989, AUTISM EXPLAINING EN Geurts HM, 2008, J AUTISM DEV DISORD, V38, P1931, DOI 10.1007/s10803-008-0587-1 GOLINKOFF RM, 1987, J CHILD LANG, V14, P23 Green G., 1974, SEMANTICS SYNTACTIC GROPEN J, 1989, LANGUAGE, V65, P203, DOI 10.2307/415332 Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093 Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003 Hovav MR, 2008, J LINGUIST, V44, P129, DOI 10.1017/S0022226707004975 Jackendoff Ray, 1983, SEMANTICS COGNITION Jackendoff Ray S., 1972, SEMANTIC INTERPRETAT Krifka M., 2001, DIP C AMST Krifka M., 1999, W COAST C FORM LING LARSON RK, 1988, LINGUIST INQ, V19, P335 Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8 Minshew NJ, 2002, NEUROPSYCHOLOGY, V16, P327, DOI 10.1037//0894-4105.16.3.327 Naigles Letitia R., 1990, J CHILD LANG, V172, P357, DOI DOI 10.1017/S0305000900013817 O'Grady W., 1987, PRINCIPLES GRAMMER L OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1107, DOI 10.1111/j.1469-7610.1991.tb00352.x Pesetsky David, 1995, ZERO SYNTAX Philofsky A, 2007, AM J SPEECH-LANG PAT, V16, P368, DOI 10.1044/1058-0360(2007/040) Pinker S., 1984, LANGUAGE LEARNABILIT Pinker Steven, 1989, LEARNABILITY COGNITI PRIOR M, 1990, J AUTISM DEV DISORD, V20, P581, DOI 10.1007/BF02216063 Saldana D, 2007, J EXP CHILD PSYCHOL, V96, P310, DOI 10.1016/j.jecp.2006.11.002 TAGERFLUSBERG H, 1981, J AUTISM DEV DISORD, V11, P45, DOI 10.1007/BF01531340 Tek S., 2008, AUTISM RES, V1, P202 Wasow Thomas, 2002, POSTVERBAL BEHAV Waxman SR, 2009, COGNITIVE PSYCHOL, V59, P67, DOI 10.1016/j.cogpsych.2009.02.001 Wechsler D., 1992, WECHSLER INTELLIGENC NR 44 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD JUN PY 2014 VL 7 IS 3 BP 314 EP 321 DI 10.1002/aur.1348 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AJ9KD UT WOS:000338027900003 PM 24227788 ER PT J AU Lane, AE Molloy, CA Bishop, SL AF Lane, Alison E. Molloy, Cynthia A. Bishop, Somer L. TI Classification of Children With Autism Spectrum Disorder by Sensory Subtype: A Case for Sensory-Based Phenotypes SO AUTISM RESEARCH LA English DT Article DE sensory; autism; phenotypes; subtypes; children; classification; model-based cluster analysis; Short Sensory Profile ID DEVELOPMENTAL DELAYS; TYPICAL DEVELOPMENT; YOUNG-CHILDREN; BEHAVIORS; ABNORMALITIES; MOTOR; INTEGRATION; RESPONSES; PATTERNS; FEATURES AB This study examines whether sensory differences can be used to classify meaningful subgroups of children with autism spectrum disorder (ASD). Caregivers of children with ASD aged 2-10 years (n=228) completed the Short Sensory Profile. Model-based cluster analysis was used to extract sensory subtypes. The relationship of these subtypes to age, gender, autism symptom severity, and nonverbal intelligence quotient (IQ) was further explored. Four distinct sensory subtypes were identified: (a) sensory adaptive; (b) taste smell sensitive; (c) postural inattentive; and (d) generalized sensory difference. The sensory subtypes differ from each other on two dimensions: (a) the severity of reported sensory differences; and (b) the focus of differences across auditory, taste, smell, vestibular and proprioceptive domains. Examination of the clinical features of each subtype reveals two possible mechanisms of sensory disturbance in autism: (a) sensory hyperreactivity; and (b) difficulties with multisensory processing. Further, the sensory subtypes are not well explained by other variables such as age, gender, IQ, and autism symptom severity. We conclude that classification of children using sensory differences offers a promising method by which to identify phenotypes in ASD. Sensory-based phenotypes may be useful in identifying behavioral features responsive to specific interventions thereby improving intervention effectiveness. Further validation of the sensory-based phenotypes by establishing neural and physiological correlates is recommended. Autism Res 2014, 7: 322-333. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Lane, Alison E.] Univ Newcastle, Sch Hlth Sci, Callaghan, NSW 2308, Australia. [Molloy, Cynthia A.] Harrison Community Network, Harrison, OH USA. [Bishop, Somer L.] Weill Cornell Med Coll, CADB, White Plains, NY USA. RP Lane, AE (reprint author), Univ Newcastle, Sch Hlth Sci, Univ Dr, Callaghan, NSW 2308, Australia. EM alison.lane@newcastle.edu.au FU U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Research Program [UA3 MC 11054]; [R01HD065277] FX The authors acknowledge the members of the Autism Speaks Autism Treatment Network (AS ATN) for use of the data. The data for the study was collected as part of the AS ATN. Further support came from a cooperative agreement (UA3 MC 11054) from the U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Research Program, to the Massachusetts General Hospital. The AS ATN includes these members: Cincinnati Children's Hospital Medical Center, Patricia Manning-Courtney, MD. The views expressed in this publication do not necessarily reflect the views of the Autism Speaks, Inc.Other acknowledgments: Dr. Bishop received support from R01HD065277. Simon Dennis, Terri Mitchell, Carrie Thomas, Chelsea Hetrick, Kerry Dalton, Kelly Tanner, Brittany Hand, Andrew Persch, Marisa Capogreco CR American Psychiatric Association, 2013, DIAGN STAT MAN MENT Ausderau K, 2014, J AUTISM DEV DISORD, V44, P915, DOI 10.1007/s10803-013-1945-1 Baker AEZ, 2008, J AUTISM DEV DISORD, V38, P867, DOI 10.1007/s10803-007-0459-0 Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2 Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650 Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x Begovac I, 2009, PSYCHIAT DANUB, V21, P310 Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3 Ben-Sasson A, 2007, AM J OCCUP THER, V61, P584 Bishop SL, 2013, J AUTISM DEV DISORD, V43, P1287, DOI 10.1007/s10803-012-1671-0 Bishop SL, 2011, AJIDD-AM J INTELLECT, V116, P331, DOI 10.1352/1944-7558-116.5.331 Boyd BA, 2010, AUTISM RES, V3, P78, DOI 10.1002/aur.124 Center for the Study of Language and Information Stanford University, 2013, STANFORD ENCY PHILOS Clifford SM, 2013, J AUTISM DEV DISORD, V43, P673, DOI 10.1007/s10803-012-1612-y Dawson G, 2002, DEV PSYCHOPATHOL, V14, P581, DOI 10.1017/S0954579402003103 Fraley Chris, 2007, J STAT SOFTW, V18, P1 Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636 Hilton C, 2007, RES AUTISM SPECT DIS, V1, P164, DOI 10.1016/j.rasd.2006.10.002 Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724 Izawa J, 2012, AUTISM RES, V5, P124, DOI 10.1002/aur.1222 Kern JK, 2006, AUTISM, V10, P480, DOI 10.1177/1362361306066564 Koenig K. P., 2008, SPECIAL INTEREST SEC, V31, P3 Lane A. E., ROBLEM EATI IN PRESS Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2 Lane AE, 2011, J AUTISM DEV DISORD, V41, P826, DOI 10.1007/s10803-010-1103-y Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7 Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lord C, 2001, AM J MED GENET, V105, P36, DOI 10.1002/1096-8628(20010108)105:1<36::AID-AJMG1053>3.0.CO;2-4 Marco EJ, 2011, PEDIATR RES, V69, p48R, DOI [10.1203/PDR.0b013e3182130c54, 10.1109/SPL.2011.5782616] Mazurek MO, 2013, J ABNORM CHILD PSYCH, V41, P165, DOI 10.1007/s10802-012-9668-x McIntosh D. N., 1999, SENSORY PROFILE EXAM, P59 McIntosh DN, 1999, DEV MED CHILD NEUROL, V41, P608, DOI 10.1017/S0012162299001267 Miller LJ, 2007, AM J OCCUP THER, V61, P135 Mullen E, 1995, MULLEN SCALES EARLY Reynolds S, 2011, J AUTISM DEV DISORD, V41, P1496, DOI 10.1007/s10803-010-1173-x Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x Roid G. H., 2003, STANFORD BINET INTEL Sober SJ, 2003, J NEUROSCI, V23, P6982 Tomchek SD, 2007, AM J OCCUP THER, V61, P190 Zhong S, 2003, J MACHINE LEARNING R, V4, P1001, DOI 10.1162/jmlr.2003.4.6.1001 NR 41 TC 3 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD JUN PY 2014 VL 7 IS 3 BP 322 EP 333 DI 10.1002/aur.1368 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AJ9KD UT WOS:000338027900004 PM 24639147 ER PT J AU Carson, AM Salowitz, NMG Scheidt, RA Dolan, BK Van Hecke, AV AF Carson, Audrey M. Salowitz, Nicole M. G. Scheidt, Robert A. Dolan, Bridget K. Van Hecke, Amy V. TI Electroencephalogram Coherence in Children With and Without Autism Spectrum Disorders: Decreased Interhemispheric Connectivity in Autism SO AUTISM RESEARCH LA English DT Article DE electroencephaolography; EEG coherence; school age3.0.CO;2-R STEIGER JH, 1990, MULTIVAR BEHAV RES, V25, P173, DOI 10.1207/s15327906mbr2502_4 Werner H., 1963, SYMBOL FORMATION ORG Williams K. T., 1997, EXPRESSIVE VOCABULAR Yoder P, 2009, J AUTISM DEV DISORD, V39, P1381, DOI 10.1007/s10803-009-0753-0 NR 25 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD APR PY 2014 VL 7 IS 2 BP 207 EP 215 DI 10.1002/aur.1360 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AE9WD UT WOS:000334361200003 PM 24550145 ER PT J AU Hollocks, MJ Jones, CRG Pickles, A Baird, G Happe, F Charman, T Simonoff, E AF Hollocks, Matthew J. Jones, Catherine R. G. Pickles, Andrew Baird, Gillian Happe, Francesca Charman, Tony Simonoff, Emily TI The Association Between Social Cognition and Executive Functioning and Symptoms of Anxiety and Depression in Adolescents With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE social cognition; anxiety; ASD; executive functions; neuropsychology; depression ID PERVASIVE DEVELOPMENTAL DISORDERS; ATTENTIONAL CONTROL-THEORY; PSYCHIATRIC-DISORDERS; GENERALIZED ANXIETY; ASPERGERS SYNDROME; MAJOR DEPRESSION; ANIMATED SHAPES; STATE ANXIETY; MENTAL STATES; SPECIAL NEEDS AB While high levels of anxiety and depression are now recognized as major co-occurring problems in children and young people with an autism spectrum disorder (ASD), research examining possible associations with individual differences in neurocognitive functioning has been limited. This study included 90 adolescents with an ASD aged 14-16 years with a full-scale IQ > 50. Using structural equation modeling, we examined the independent relationships between multiple measures of executive functioning and social cognition on severity of anxiety or depressive symptoms. Results indicated a significant association between poorer executive functioning and higher levels of anxiety, but not depression. In contrast, social cognition ability was not associated with either anxiety or depression. This study is the first to report significant associations between executive functions and anxiety in ASD. This may suggest that poor executive functioning is one factor associated with the high prevalence of anxiety disorder in children and adolescents with ASD. Autism Res 2014, 7: 216-228. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Hollocks, Matthew J.; Simonoff, Emily] Kings Coll London, Dept Child & Adolescent Psychiat, Inst Psychiat, London SE5 8AF, England. [Jones, Catherine R. G.] Cardiff Univ, Sch Psychol, Cardiff CF10 3AX, S Glam, Wales. [Pickles, Andrew] Kings Coll London, Dept Biostat, Inst Psychiat, London SE5 8AF, England. [Pickles, Andrew] Kings Coll London, Biomed Res Ctr Mental Hlth, Inst Psychiat, London SE5 8AF, England. [Baird, Gillian] Guys & St Thomas NHS Fdn Trust, London, England. [Happe, Francesca] Kings Coll London, MRC SGDP Res Ctr, Inst Psychiat, London SE5 8AF, England. [Charman, Tony] Kings Coll London, Dept Psychol, Inst Psychiat, London SE5 8AF, England. [Simonoff, Emily] Kings Coll London, NIHR Biomed Res Ctr Mental Hlth, Inst Psychiat, London SE5 8AF, England. RP Hollocks, MJ (reprint author), Kings Coll London, Dept Child & Adolescent Psychiat, Inst Psychiat, PO85,De Crespigny Pk,Denmark Hill, London SE5 8AF, England. EM matthew.hollocks@kcl.ac.uk RI Charman, Tony/A-2085-2014; Jones, Catherine/E-4956-2013; Pickles, Andrew/A-9625-2011 OI Charman, Tony/0000-0003-1993-6549; Pickles, Andrew/0000-0003-1283-0346 FU Medical Research Council [G0400065]; Novartis FX The study was funded by the Medical Research Council (G0400065). We are grateful to the adolescents and families who took part in the study. We would like to thank Paramala Santosh for permission to reprint the relevant items from the PONS. A.P. receives royalties from the Social Communication Questionnaire and F. H. received a one-off consultancy payment from Novartis in March 2011. There are no other conflicts of interest, financial or otherwise. CR Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9 Airaksinen E, 2005, J PSYCHIAT RES, V39, P207, DOI 10.1016/j.jpsychires.2004.06.001 Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Baron-Cohen S., 2001, J DEV LEARNING DISOR, V5, P47 BARONCOHEN S, 1989, J CHILD PSYCHOL PSYC, V30, P285, DOI 10.1111/j.1469-7610.1989.tb00241.x Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201 Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201 Bishop SJ, 2004, J NEUROSCI, V24, P10364, DOI 10.1523/JNEUROSCI.2550-04.2004 Bishop SJ, 2007, TRENDS COGN SCI, V11, P307, DOI 10.1016/j.tics.2007.05.008 BOWLER DM, 1992, J CHILD PSYCHOL PSYC, V33, P877, DOI 10.1111/j.1469-7610.1992.tb01962.x Castaneda AE, 2008, J AFFECT DISORDERS, V106, P1, DOI 10.1016/j.jad.2007.06.006 Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189 Charman T, 2011, PSYCHOL MED, V41, P619, DOI 10.1017/S0033291710000991 Cohen M. J., 1997, CHILDRENS MEMORY SCA Corbetta M, 2002, NAT REV NEUROSCI, V3, P201, DOI 10.1038/nrn755 Cusi AM, 2013, PSYCHIAT RES, V210, P672, DOI 10.1016/j.psychres.2013.06.018 Dalgleish T, 2003, J CLIN CHILD ADOLESC, V32, P10, DOI 10.1207/15374420360533022 Derakshan N, 2009, PSYCHON B REV, V16, P1112, DOI 10.3758/PBR.16.6.1112 Derakshan N, 2009, EXP PSYCHOL, V56, P48, DOI 10.1027/1618-3169.56.1.48 Derryberry D, 2002, J ABNORM PSYCHOL, V111, P225, DOI 10.1037//0021-843X.111.2.225 Eussen M. L., 2012, AUTISM INT J RES PRA, V17, P723 Eysenck MW, 2007, EMOTION, V7, P336, DOI 10.1037/1528-3542.7.2.336 Favre T, 2009, CHILD NEUROPSYCHOL, V15, P85, DOI 10.1080/09297040802577311 Goodman R, 2003, INT REV PSYCHIATR, V15, P166, DOI 10.1080/0954026021000046128 Gotham K., 2012, AUTISM RES, V6, P33 GRANT DA, 1948, J EXP PSYCHOL, V38, P404, DOI 10.1037/h0059831 Gresham F. M., 1990, SOCIAL SKILLS RATING Gunther T, 2004, J AFFECT DISORDERS, V82, P265, DOI 10.1016/j.jad.2003.11.004 Hallett V, 2013, J AUTISM DEV DISORD, V43, P2341, DOI 10.1007/s10803-013-1775-1 Hallett V, 2012, J ABNORM CHILD PSYCH, V40, P815, DOI 10.1007/s10802-011-9596-1 Happe F, 1996, BRAIN, V119, P1377, DOI 10.1093/brain/119.4.1377 HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093 Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003 Hughes C, 1998, J CHILD PSYCHOL PSYC, V39, P981, DOI 10.1017/S0021963098003059 Inoue Y, 2006, J AFFECT DISORDERS, V95, P125, DOI 10.1016/j.jad.2006.04.018 Jefferies LN, 2008, PSYCHOL SCI, V19, P290, DOI 10.1111/j.1467-9280.2008.02082.x Jones CRG, 2011, AUTISM RES, V4, P347, DOI 10.1002/aur.209 Konstantareas MM, 2006, J AUTISM DEV DISORD, V36, P143, DOI 10.1007/s10803-005-0051-4 Lau Jennifer Y F, 2012, Biol Mood Anxiety Disord, V2, P12, DOI 10.1186/2045-5380-2-12 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Losh M, 2006, DEV PSYCHOL, V42, P809, DOI 10.1037/0012-1649.42.5.809 Lugnegard T, 2011, RES DEV DISABIL, V32, P1910, DOI 10.1016/j.ridd.2011.03.025 Manly T, 2001, J CHILD PSYCHOL PSYC, V42, P1065, DOI 10.1111/1469-7610.00806 Matthews K, 2008, J AFFECT DISORDERS, V111, P113, DOI 10.1016/j.jad.2008.02.003 Mazefsky CA, 2010, AUTISM RES, V3, P120, DOI 10.1002/aur.133 Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y Muthen L., 2012, MPLUS COMPREHENSIVE, P5 Niditch LA, 2012, J CLIN CHILD ADOLESC, V41, P127, DOI 10.1080/15374416.2012.651994 NISBETT RE, 1977, J PERS SOC PSYCHOL, V35, P250, DOI 10.1037/0022-3514.35.4.250 Ornstein T. J., 2009, DEPRESS ANXIETY, V27, P372 Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x Rapee RM, 2009, ANNU REV CLIN PSYCHO, V5, P311, DOI 10.1146/annurev.clinpsy.032408.153628 REITAN R. M., 1958, PERCEPT MOT SKILLS, V8, P271 Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd Rodgers J, 2012, J AUTISM DEV DISORD, V42, P2404, DOI 10.1007/s10803-012-1531-y Rutter M., 2003, SOCIAL COMMUNICATION Samson AC, 2012, EMOTION, V12, P659, DOI 10.1037/a0027975 Santosh PJ, 2006, CHILD CARE HLTH DEV, V32, P575, DOI 10.1111/j.1365-2214.2006.00631.x Simonoff E, 2012, J CHILD PSYCHOL PSYC, V53, P1157, DOI 10.1111/j.1469-7610.2012.02600.x Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f Spiker MA, 2012, AUTISM, V16, P306, DOI 10.1177/1362361311401763 StataCorp LP, 2009, STAT 11 BAS REF MAN Storch EA, 2012, J AUTISM DEV DISORD, V42, P2374, DOI 10.1007/s10803-012-1489-9 Strang JF, 2012, RES AUTISM SPECT DIS, V6, P406, DOI 10.1016/j.rasd.2011.06.015 Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9 Toren P, 2000, J ANXIETY DISORD, V14, P239, DOI 10.1016/S0887-6185(99)00036-5 Tregay J, 2009, BRIT J DEV PSYCHOL, V27, P283, DOI 10.1348/026151008X299737 van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0 Wang YG, 2008, PSYCHIAT RES, V161, P153, DOI 10.1016/j.psychres.2007.07.018 Waters AM, 2008, J AM ACAD CHILD PSY, V47, P435, DOI 10.1097/CHI.0b013e3181642992 Waters AM, 2010, J BEHAV THER EXP PSY, V41, P158, DOI 10.1016/j.jbtep.2009.12.001 Wechsler D, 1999, WECHSLER ABBREVIATED Weisbrot DM, 2005, J CHILD ADOL PSYCHOP, V15, P477, DOI 10.1089/cap.2005.15.477 Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x Wood Richard John, 1997, EVALUATING STRESS BO, Vxvii, P23 NR 76 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD APR PY 2014 VL 7 IS 2 BP 216 EP 228 DI 10.1002/aur.1361 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AE9WD UT WOS:000334361200004 PM 24737743 ER PT J AU Iarocci, G Armstrong, K AF Iarocci, Grace Armstrong, Kimberly TI Age-Related Changes in Conjunctive Visual Search in Children with and without ASD SO AUTISM RESEARCH LA English DT Article DE attention; perception; development; visual search ID AUTISM; SUPERIOR; ATTENTION; ADULTS; TARGET; TASKS AB Visual-spatial strengths observed among people with autism spectrum disorder (ASD) may be associated with increased efficiency of selective attention mechanisms such as visual search. In a series of studies, researchers examined the visual search of targets that share features with distractors in a visual array and concluded that people with ASD showed enhanced performance on visual search tasks. However, methodological limitations, the small sample sizes, and the lack of developmental analysis have tempered the interpretations of these results. In this study, we specifically addressed age-related changes in visual search. We examined conjunctive visual search in groups of children with (n = 34) and without ASD (n = 35) at 7-9 years of age when visual search performance is beginning to improve, and later, at 10-12 years, when performance has improved. The results were consistent with previous developmental findings; 10- to 12-year-old children were significantly faster visual searchers than their 7- to 9-year-old counterparts. However, we found no evidence of enhanced search performance among the children with ASD at either the younger or older ages. More research is needed to understand the development of visual search in both children with and without ASD. Autism Res 2014, 7: 229-236. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Iarocci, Grace; Armstrong, Kimberly] Simon Fraser Univ, Dept Psychol, Burnaby, BC V5A 1S6, Canada. RP Iarocci, G (reprint author), Simon Fraser Univ, Dept Psychol, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada. EM giarocci@sfu.ca FU Social Sciences and Humanities Research Council of Canada (SSHRC) [767-2011-2317]; Michael Smith Foundation for Health Research (MSFHR); Autism Research Training (ART) program; Canadian Institutes of Health Research (CIHR) [STN 63728] FX This research was supported by: Grant Sponsor: Social Sciences and Humanities Research Council of Canada (SSHRC); Grant Number: 767-2011-2317 to G. I.; Grant Sponsor: Michael Smith Foundation for Health Research (MSFHR); Scholar Award to G. I. Grant Sponsor: Autism Research Training (ART) program funded by the Canadian Institutes of Health Research (CIHR); Grant Number: STN 63728 to K.A. CR Auyeung B, 2008, J AUTISM DEV DISORD, V38, P1230, DOI 10.1007/s10803-007-0504-z Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561 Chun MM, 1996, COGNITIVE PSYCHOL, V30, P39, DOI 10.1006/cogp.1996.0002 DUNCAN J, 1989, PSYCHOL REV, V96, P433, DOI 10.1037//0033-295X.96.3.433 Howell D., 2009, STAT METHODS PSYCHOL Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x Kaldy Z, 2011, DEVELOPMENTAL SCI, V14, P980, DOI 10.1111/j.1467-7687.2011.01053.x Kemner C, 2008, J AUTISM DEV DISORD, V38, P553, DOI 10.1007/s10803-007-0406-0 Lobaugh NJ, 1998, CAN J EXP PSYCHOL, V52, P201, DOI 10.1037/h0087293 Merrill EC, 2004, J EXP CHILD PSYCHOL, V89, P72, DOI 10.1016/j.jecp.2004.04.001 Merrill EC, 2013, J EXP CHILD PSYCHOL, V115, P640, DOI 10.1016/j.jecp.2013.03.013 Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P743, DOI 10.1017/S0021963098003795 O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719 O'Riordan MA, 2004, AUTISM, V8, P229, DOI 10.1177/1362361304045219 Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613 PLUDE DJ, 1994, ACTA PSYCHOL, V86, P227, DOI 10.1016/0001-6918(94)90004-3 RUMSEY JM, 1988, J CLIN EXP NEUROPSYC, V10, P201, DOI 10.1080/01688638808408236 Shafai F., 2013, J VISION, V13, P841 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x Smilek D, 2006, VIS COGN, V14, P543, DOI 10.1080/13506280500193487 STERLING TD, 1995, AM STAT, V49, P108, DOI 10.2307/2684823 Treisman A. M., 2000, VISUAL PERCEPTION ES, P347 Trick LM, 1998, COGNITIVE DEV, V13, P369, DOI 10.1016/S0885-2014(98)90016-8 WOLFE JM, 1989, J EXP PSYCHOL HUMAN, V15, P419, DOI 10.1037/0096-1523.15.3.419 NR 25 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD APR PY 2014 VL 7 IS 2 BP 229 EP 236 DI 10.1002/aur.1359 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AE9WD UT WOS:000334361200005 PM 24574200 ER PT J AU Brodeur, DA Green, CG Flores, H Burack, JA AF Brodeur, Darlene A. Green, Cathryn Gordon Flores, Heidi Burack, Jacob A. TI Time Estimation Among Low-Functioning Individuals With Autism Spectrum Disorders: Evidence of Poor Sensitivity to Variability of Short Durations SO AUTISM RESEARCH LA English DT Article DE perception; autism spectrum disorder; time; low-functioning ID PERCEPTION; CHILDREN; ADULTS; MEMORY; AGE AB Time estimation of short durations (under 1 sec) was examined in low-functioning individuals with autism spectrum disorder (ASD) and typically developing (TD) children matched on mental age. Temporal bisection and generalization tasks were used to examine basic perceptual timing mechanisms. For both tasks, the participants with ASD demonstrated less sensitivity to variability in short durations than the TD children, adding to a growing body of literature suggesting deficits in timing exist for longer durations. The results highlight the need to examine multiple levels of processing of time-related information from basic perceptual mechanisms to higher level cognitive mechanisms. Autism Res 2014, 7: 237-244. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Brodeur, Darlene A.] Acadia Univ, Dept Psychol, Wolfville, NS B4P 2R6, Canada. [Green, Cathryn Gordon; Flores, Heidi; Burack, Jacob A.] McGill Univ, Hop Riviere Des Prairies, Montreal, PQ, Canada. RP Brodeur, DA (reprint author), Acadia Univ, Dept Psychol, 18 Univ Ave, Wolfville, NS B4P 2R6, Canada. EM darlene.brodeur@acadiau.ca FU Social Sciences and Humanities Research Council Canada Standard Research Grant [410-2009-1144] FX Grant sponsor: Social Sciences and Humanities Research Council Canada Standard Research Grant to Jake Burack; Grant number: #410-2009-1144. CR Allen G, 2003, AM J PSYCHIAT, V160, P262, DOI 10.1176/appi.ajp.160.2.262 Allman M. J., 2011, FRONTIERS INTEGRATIV, V5, P1 Allman MJ, 2011, AJIDD-AM J INTELLECT, V116, P165, DOI 10.1352/1944-7558-116.2.165 Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003 Courchesne E, 2001, NEUROLOGY, V57, P245 Droit-Volet S, 2007, BEHAV PROCESS, V74, P244, DOI 10.1016/j.beproc.2006.09.012 Droit-Volet S, 2004, Q J EXP PSYCHOL-A, V57, P797, DOI 10.1080/02724980343000495 Falter C. M., 2013, Q J EXPT PSYCHOL, V65, P2093 Falter CM, 2009, BEHAV BRAIN SCI, V32, P335, DOI 10.1017/S0140525X09990045 Jones CRG, 2009, NEUROPSYCHOLOGIA, V47, P2850, DOI 10.1016/j.neuropsychologia.2009.06.015 Maister L, 2011, DEVELOPMENTAL SCI, V14, P1311, DOI 10.1111/j.1467-7687.2011.01077.x Martin J. S., 2010, J AUTISM DEV DISORD, V4, P640 McCormack T, 1999, DEV PSYCHOL, V35, P1143, DOI 10.1037/0012-1649.35.4.1143 McCormack T, 2005, Q J EXP PSYCHOL-A, V58, P693, DOI 10.1080/02724980443000250 Mostofsky SH, 2009, BRAIN, V132, P2413, DOI 10.1093/brain/awp088 Mostofsky SH, 2000, J INT NEUROPSYCH SOC, V6, P752, DOI 10.1017/S1355617700677020 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Mottron L, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P131 O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527 O'Riordan M, 2001, Q J EXP PSYCHOL-A, V54, P961, DOI 10.1080/02724980042000543 O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719 Penney TB, 2000, J EXP PSYCHOL HUMAN, V26, P1770, DOI 10.1037//0096-1523.26.6.1770 Plaisted KC, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P149 Remington AM, 2012, J ABNORM PSYCHOL, V121, P544, DOI 10.1037/a0027670 Roid G., 1997, LEITER INT PERFORMAN Rutherford MD, 2007, COGN NEUROPSYCHOL, V24, P505, DOI 10.1080/02643290701508224 Szelag E, 2004, BRIT J PSYCHOL, V95, P269, DOI 10.1348/0007126041528167 Wallace GL, 2008, RES AUTISM SPECT DIS, V2, P447, DOI 10.1016/j.rasd.2007.09.005 Wearden JH, 1997, J EXP PSYCHOL HUMAN, V23, P962 NR 29 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD APR PY 2014 VL 7 IS 2 BP 237 EP 244 DI 10.1002/aur.1364 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AE9WD UT WOS:000334361200006 PM 24574256 ER PT J AU Yuan, H Dougherty, JD AF Yuan, Han Dougherty, Joseph D. TI Investigation of Maternal Genotype Effects in Autism by Genome-Wide Association SO AUTISM RESEARCH LA English DT Article DE autism; GWAS; SSC; maternal genotype effect; AGRE ID FETAL VALPROATE SYNDROME; SPECTRUM DISORDERS; CONGENITAL CYTOMEGALOVIRUS; RISK-FACTORS; TWIN PAIRS; ALCOHOL; MOTHERS; IDENTIFICATION; METAANALYSIS; MUTATIONS AB Like most psychiatric disorders, autism spectrum disorders have both a genetic and an environmental component. While previous studies have clearly demonstrated the contribution of in utero (prenatal) environment on autism risk, most of them focused on transient environmental factors. Based on a recent sibling study, we hypothesized that environmental factors could also come from the maternal genome, which would result in persistent effects across siblings. In this study, the possibility of maternal genotype effects was examined by looking for common variants (single-nucleotide polymorphisms or SNPs) in the maternal genome associated with increased risk of autism in children. A case/control genome-wide association study was performed using mothers of probands as cases, and either fathers of probands or normal females as controls. Autism Genetic Resource Exchange and Illumina Genotype Control Database were used as our discovery cohort (n = 1616). The same analysis was then replicated on Simon Simplex Collection and Study of Addiction: Genetics and Environment datasets (n = 2732). We did not identify any SNP that reached genome-wide significance (P < 10(-8)), and thus a common variant of large effect is unlikely. However, there was evidence for the possibility of a large number of alleles of effective size marginally below our power to detect. Autism Res 2014, 7: 245-253. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Yuan, Han; Dougherty, Joseph D.] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA. [Dougherty, Joseph D.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA. RP Dougherty, JD (reprint author), Washington Univ, Sch Med, Dept Genet, 4566 Scott Ave,Campus Box 8232, St Louis, MO 63110 USA. EM jdougherty@genetics.wustl.edu FU Mallinkrodt Foundation; National Institutes of Health (NIH) [4R00NS067239 -03, 9R01MH100027-06]; National Institute of Mental Health [1U24MH081810]; NIH Genes, Environment and Health Initiative (GEI) [U01 HG004422]; Gene Environment Association Studies (GENEVA) under GEI; Collaborative Study on the Genetics of Alcoholism (COGA) [U10 AA008401]; Collaborative Genetic Study of Nicotine Dependence (COGEND) [P01 CA089392]; Family Study of Cocaine Dependence (FSCD) [R01 DA013423]; NIH GEI [U01HG004438]; National Institute on Alcohol Abuse and Alcoholism; National Institute on Drug Abuse; NIH [HHSN268200782096C] FX We gratefully thank John Constantino, Jennifer K. Lowe, Don Conrad, Laura Bierut, Nancy Saccone, and members of Dougherty lab for their suggestions and support. Funding was provided by the Mallinkrodt Foundation (J. D. D.) and the National Institutes of Health (NIH): 4R00NS067239 -03 (J. D. D.) and 9R01MH100027-06. The authors declare no conflicts of interest.We are also grateful for the resources provided by the Autism Genetic Resource Exchange (AGRE) Consortium* and the participating AGRE families. The Autism Genetic Resource Exchange is a program of Autism Speaks and is supported, in part, by grant 1U24MH081810 from the National Institute of Mental Health to Clara M. Lajonchere (PI). We are likewise grateful to all of the families at the participating Simons Simplex Collection (SSC) sites, as well as the principal investigators (A. Beaudet, R. Bernier, J. Constantino, E. Cook, E. Fombonne, D. Geschwind, R. Goin-Kochel, E. Hanson, D. Grice, A. Klin, D. Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles, O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren, and E. Wijsman). Funding support for the Study of Addiction: Genetics and Environment (SAGE) was provided through the NIH Genes, Environment and Health Initiative (GEI) (U01 HG004422). SAGE is one of the genome-wide association studies funded as part of the Gene Environment Association Studies (GENEVA) under GEI. Assistance with phenotype harmonization and genotype cleaning, as well as with general study coordination, was provided by the GENEVA Coordinating Center (U01 HG004446). Assistance with data cleaning was provided by the National Center for Biotechnology Information. Support for collection of datasets and samples was provided by the Collaborative Study on the Genetics of Alcoholism (COGA; U10 AA008401), the Collaborative Genetic Study of Nicotine Dependence (COGEND; P01 CA089392), and the Family Study of Cocaine Dependence (FSCD; R01 DA013423). Funding support for genotyping, which was performed at the Johns Hopkins University Center for Inherited Disease Research, was provided by the NIH GEI (U01HG004438), the National Institute on Alcohol Abuse and Alcoholism, the National Institute on Drug Abuse, and the NIH contract "High throughput genotyping for studying the genetic contributions to human disease" (HHSN268200782096C). CR Ainsworth HE, 2011, GENET EPIDEMIOL, V35, P19, DOI 10.1002/gepi.20547 Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301 Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307 Aronson M, 1997, DEV MED CHILD NEUROL, V39, P583 Autism and Developmental Disabilities Monitoring Network Surveillance Principal Investigators, 2012, MMWR SURVEILL SUMM, V61, P1 Bierut LJ, 2010, P NATL ACAD SCI USA, V107, P5082, DOI 10.1073/pnas.0911109107 BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x Boraska V, 2012, HUM MOL GENET, V21, P4805, DOI 10.1093/hmg/dds304 Carney JA, 2010, AM J SURG PATHOL, V34, P547, DOI 10.1097/PAS.0b013e3181d31f49 Ceyhan O, 2012, CHEM BIOL, V19, P155, DOI 10.1016/j.chembiol.2011.12.010 CHRISTIANSON AL, 1994, DEV MED CHILD NEUROL, V36, P361 Constantino J. N., 2012, MOL PSYCHIATR, V18, P137, DOI [10.1038/mp.2012.9, DOI 10.1038/MP.2012.9] Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470 Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006 Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559 Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672 Geschwind DH, 2001, AM J HUM GENET, V69, P463, DOI 10.1086/321292 GILLBERG IC, 1992, J CHILD PSYCHOL PSYC, V33, P531, DOI 10.1111/j.1469-7610.1992.tb00889.x Haddow JE, 1999, NEW ENGL J MED, V341, P549, DOI 10.1056/NEJM199908193410801 Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76 Howey R, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-149 Hsiao EY, 2012, P NATL ACAD SCI USA, V109, P12776, DOI 10.1073/pnas.1202556109 Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009 Jamieson S. E., 2008, PLOS ONE, V3, P6 Jensen LE, 2006, AM J MED GENET A, V140A, P1114, DOI 10.1002/ajmg.a.31212 Johnson WG, 2003, BIOESSAYS, V25, P464, DOI 10.1002/bies.10268 Johnson WG, 2009, ARCH PEDIAT ADOL MED, V163, P542, DOI 10.1001/archpediatrics.2009.74 Larizza D, 2002, J PEDIATR ENDOCR MET, V15, P1183 Li Y, 2010, GENET EPIDEMIOL, V34, P816, DOI 10.1002/gepi.20533 Marchini J, 2010, NAT REV GENET, V11, P499, DOI 10.1038/nrg2796 Miller M. S., 1993, THALIDOMIDE EMBRYOPA Moldin S. O., 2006, UNDERSTANDING AUTISM NANSON JL, 1992, ALCOHOL CLIN EXP RES, V16, P558, DOI 10.1111/j.1530-0277.1992.tb01417.x OBER C, 1987, AM J REPROD IMMUNOL, V15, P141 Palmer CGS, 2006, AM J HUM GENET, V79, P710, DOI 10.1086/507829 Price AL, 2006, NAT GENET, V38, P904, DOI 10.1038/ng1847 Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795 Ronald A, 2011, AM J MED GENET B, V156B, P255, DOI 10.1002/ajmg.b.31159 Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98 Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002 Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945 Schaaf CP, 2011, NEURON, V70, P806, DOI 10.1016/j.neuron.2011.05.025 Shih RA, 2004, INT REV PSYCHIATR, V16, P260, DOI 10.1080/09540260400014401 Skol AD, 2006, NAT GENET, V38, P209, DOI 10.1038/ng1706 STROMLAND K, 1994, DEV MED CHILD NEUROL, V36, P351 STUBBS EG, 1984, J AUTISM DEV DISORD, V14, P183, DOI 10.1007/BF02409660 STUBBS EG, 1978, J AUTISM CHILD SCHIZ, V8, P37, DOI 10.1007/BF01550276 Sumi S, 2006, J HUM GENET, V51, P518, DOI 10.1007/s10038-006-0392-7 Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490 Williams PG, 1997, DEV MED CHILD NEUROL, V39, P632 Williams TA, 2007, ARCH PEDIAT ADOL MED, V161, P356, DOI 10.1001/archpedi.161.4.356 NR 52 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD APR PY 2014 VL 7 IS 2 BP 245 EP 253 DI 10.1002/aur.1363 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AE9WD UT WOS:000334361200007 PM 24574247 ER PT J AU Ceroni, F Sagar, A Simpson, NH Gawthrope, AJT Newbury, DF Pinto, D Francis, SM Tessman, DC Cook, EH Monaco, AP Maestrini, E Pagnamenta, AT Jacob, S AF Ceroni, Fabiola Sagar, Angela Simpson, Nuala H. Gawthrope, Alex J. T. Newbury, Dianne F. Pinto, Dalila Francis, Sunday M. Tessman, Dorothy C. Cook, Edwin H. Monaco, Anthony P. Maestrini, Elena Pagnamenta, Alistair T. Jacob, Suma TI A Deletion Involving CD38 and BST1 Results in a Fusion Transcript in a Patient With Autism and Asthma SO AUTISM RESEARCH LA English DT Article DE CNV; oxytocin; fusion transcript; autism; CD38 ID RECEPTOR GENE OXTR; PERVASIVE DEVELOPMENTAL DISORDERS; AIRWAY SMOOTH-MUSCLE; SPECTRUM DISORDER; OXYTOCIN SECRETION; GENOMIC DISORDERS; BRAIN OXYTOCIN; ASSOCIATION; CHILDREN; BEHAVIOR AB CD38 encodes a ligand in the oxytocin signaling pathway. Some single nucleotide polymorphisms in this gene have been associated with low serum oxytocin levels in autism spectrum disorder (ASD) patients. Oxytocin disruption has been hypothesized to account for features of ASD, including impaired communication and social behavior, based on animal studies. Recent human studies have shown administration of oxytocin improving emotion recognition, promoting social behavior, and improving auditory processing of social stimuli in ASD patients. In addition to its role in oxytocin signaling, CD38 is involved in the regulation of calcium concentration in airway smooth muscle with impairment of CD38 being implicated in airway diseases like asthma. While a number of studies have implicated rare chromosomal deletions and duplications in helping determine genetic risk for autism, there are to our knowledge no reports describing rearrangements involving CD38 or deletions in patients with ASD. Here, we present two sisters diagnosed with autism and with features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. Their mother's deletion was mosaic and she was not affected. Although further work is required to assess functional consequences of the fusion transcript, we hypothesize that the proband's deletion may have served as a risk factor for autism that, when combined with other susceptibility variants, resulted in a more severe presentation than her sister. Autism Res 2014, 7: 254-263. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Ceroni, Fabiola; Maestrini, Elena] Univ Bologna, Dept Pharm & Biotechnol, Bologna, Italy. [Simpson, Nuala H.; Gawthrope, Alex J. T.; Newbury, Dianne F.; Monaco, Anthony P.; Pagnamenta, Alistair T.] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. [Sagar, Angela; Tessman, Dorothy C.; Cook, Edwin H.] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA. [Pinto, Dalila] Icahn Sch Med, Dept Psychiat, New York, NY USA. [Monaco, Anthony P.] Tufts Univ, Dept Neurosci, Medford, MA 02155 USA. [Francis, Sunday M.; Jacob, Suma] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA. RP Jacob, S (reprint author), Univ Minnesota, Wallin Med Biosci Bldg,2101 6th St SE, Minneapolis, MN 55455 USA. EM sjacob@umn.edu RI Monaco, Anthony/A-4495-2010; Jacob, Suma/J-7941-2013 OI Monaco, Anthony/0000-0001-7480-3197; Jacob, Suma/0000-0001-7434-7398 FU NIH Autism Center of Excellence [P50 HD055751, K23MH082121]; MRC [G1000569/1]; Wellcome Trust [090532/Z/09/Z]; NIHR Biomedical Research Centre Oxford; Department of Health's NIHR Biomedical Research Centres funding scheme; [5T32MH067631-07] FX We thank the patients and their family for their cooperation, assistance, and support in this project. This work was supported in part by 5T32MH067631-07 Training in the Neuroscience of Mental Health (A. S.), NIH Autism Center of Excellence P50 HD055751 (E. H. C.), K23MH082121 (S.J.), the MRC [G1000569/1] (D.N.), the Wellcome Trust (090532/Z/09/Z), and the NIHR Biomedical Research Centre Oxford, with funding from the Department of Health's NIHR Biomedical Research Centres funding scheme. The views expressed in this publication are those of the authors and not necessarily those of the Department of Health. Dianne Newbury is an MRC Career Development Fellow and a Junior Research Fellow at St John's College. We would like to acknowledge Zoe Holloway for technical assistance with the preliminary Western analysis, and Steve Guter for assistance with the clinical data. The authors have no conflicts of interest to disclose. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307 Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILLANCE SU, V61, P1 BAILEY A, 1995, PSYCHOL MED, V25, P63 Campbell DB, 2011, J NEURODEV DISORD, V3, P101, DOI 10.1007/s11689-010-9071-2 Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133 Deshpande DA, 2005, AM J PHYSIOL-LUNG C, V288, pL773, DOI 10.1152/ajplung.00217.2004 Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd Girirajan S, 2012, NEW ENGL J MED, V367, P1321, DOI 10.1056/NEJMoa1200395 Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62 Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76 Higashida H, 2011, BIOL PHARM BULL, V34, P1369 Higashida H, 2012, NEUROCHEM INT, V61, P828, DOI 10.1016/j.neuint.2012.01.030 Holt R, 2012, EUR J HUM GENET, V20, P1141, DOI 10.1038/ejhg.2012.73 IMGSAC, 1998, HUM MOL GENET, V7, P571 Insel TR, 1999, BIOL PSYCHIAT, V45, P145, DOI 10.1016/S0006-3223(98)00142-5 Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001 Jin D, 2007, NATURE, V446, P41, DOI 10.1038/nature05526 KAISHO T, 1994, P NATL ACAD SCI USA, V91, P5325, DOI 10.1073/pnas.91.12.5325 Lee JA, 2007, CELL, V131, P1235, DOI 10.1016/j.cell.2007.11.037 Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087 Lerer E, 2010, AUTISM RES, V3, P293, DOI 10.1002/aur.156 Liu XX, 2010, J HUM GENET, V55, P137, DOI 10.1038/jhg.2009.140 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Matsumoto H, 2012, CYTOKINE, V57, P19, DOI 10.1016/j.cyto.2011.10.014 Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3 Mullen E, 1995, MULLEN SCALES EARLY Munesue T, 2010, NEUROSCI RES, V67, P181, DOI 10.1016/j.neures.2010.03.004 Neumann ID, 2012, TRENDS NEUROSCI, V35, P649, DOI 10.1016/j.tins.2012.08.004 Pagnamenta AT, 2010, BIOL PSYCHIAT, V68, P320, DOI 10.1016/j.biopsych.2010.02.002 Peeraully Tasneem, 2012, Parkinsonism Relat Disord, V18 Suppl 1, pS63, DOI 10.1016/S1353-8020(11)70021-9 Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 Raven J, 2000, COGNITIVE PSYCHOL, V41, P1, DOI 10.1006/cogp.1999.0735 Raven JC, 1947, PROGR MATRICES SETS Sauer C, 2012, NEUROPSYCHOPHARMACOL, V37, P1474, DOI 10.1038/npp.2011.333 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 Sparrow SS, 2005, VINELAND ADAPTIVE BE Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974 Wermter AK, 2010, AM J MED GENET B, V153B, P629, DOI 10.1002/ajmg.b.31032 Wiig E. H., 1992, CLIN EVALUATION LANG Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013 Yrigollen CM, 2008, BIOL PSYCHIAT, V63, P911, DOI 10.1016/j.biopsych.2007.11.015 NR 43 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD APR PY 2014 VL 7 IS 2 BP 254 EP 263 DI 10.1002/aur.1365 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AE9WD UT WOS:000334361200008 PM 24634087 ER PT J AU Jaramillo, TC Liu, SN Pettersen, A Birnbaum, SG Powell, CM AF Jaramillo, Thomas C. Liu, Shunan Pettersen, Ami Birnbaum, Shari G. Powell, Craig M. TI Autism-Related Neuroligin-3 Mutation Alters Social Behavior and Spatial Learning SO AUTISM RESEARCH LA English DT Article DE animal models; neuroligin; intellectual disability; autism; behavioral analysis of animal models ID SYNAPTIC-TRANSMISSION; MICE; DISORDER; GENES AB Multiple candidate genes have been identified for autism spectrum disorders. While some of these genes reach genome-wide significance, others, such as the R451C point mutation in the synaptic cell adhesion molecule neuroligin-3, appear to be rare. Interestingly, two brothers with the same R451C point mutation in neuroligin-3 present clinically on seemingly disparate sides of the autism spectrum. These clinical findings suggest genetic background may play a role in modifying the penetrance of a particular autism-associated mutation. Animal models may contribute additional support for such mutations as functionally relevant and can provide mechanistic insights. Previously, in collaboration with the Sudhof laboratory, we reported that mice with an R451C substitution in neuroligin-3 displayed social deficits and enhanced spatial learning. While some of these behavioral abnormalities have since been replicated independently in the Sudhof laboratory, observations from the Crawley laboratory failed to replicate these findings in a similar neuroligin-3 mutant mouse model and suggested that genetic background may contribute to variation in observations across laboratories. Therefore, we sought to replicate our findings in the neuroligin-3 R451C point mutant knock-in mouse model (NL3R451C) in a different genetic background. We backcrossed our NL3R451C mouse line onto a 129S2/SvPasCrl genetic background and repeated a subset of our previous behavioral testing. NL3R451C mice on a 129S2/SvPasCrl displayed social deficits, enhanced spatial learning, and increased locomotor activity. These data extend our previous findings that NL3R451C mice exhibit autism-relevant behavioral abnormalities and further suggest that different genetic backgrounds can modify this behavioral phenotype through epistatic genetic interactions. Autism Res 2014, 7: 264-272. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Jaramillo, Thomas C.; Liu, Shunan; Powell, Craig M.] Univ Texas SW Med Ctr Dallas, Dept Neurol & Neurotherapeut, Dallas, TX 75390 USA. [Pettersen, Ami; Birnbaum, Shari G.; Powell, Craig M.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA. [Powell, Craig M.] Univ Texas SW Med Ctr Dallas, Grad Program Neurosci, Dallas, TX 75390 USA. RP Powell, CM (reprint author), Univ Texas SW Med Ctr Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM craig.powell@utsouthwestern.edu FU NIMH [MH081164]; Autism Speaks; The Hartwell Foundation FX This work was supported by the NIMH MH081164 (CMP), Autism Speaks (CMP), and The Hartwell Foundation (CMP). TCJ and CMP conceived and designed the experiments; TCJ, SL, and AP carried them out with input from CMP and SB; TCJ performed statistical analysis; and TCJ and CMP wrote the paper with input from all authors. We thank Dr. Thomas C. Sudhof for the gift of NL3 mutant mice. The authors declare no competing interests. CR BARNARD CJ, 1991, BIOL REV, V66, P379, DOI 10.1111/j.1469-185X.1991.tb01147.x Blundell J, 2009, GENES BRAIN BEHAV, V8, P114, DOI 10.1111/j.1601-183X.2008.00455.x Bozdagi O., 2010, COMMUNICATION, V1, P1 Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22 Chih B, 2004, HUM MOL GENET, V13, P1471, DOI 10.1093/hmg/ddh158 Comoletti D, 2004, J NEUROSCI, V24, P4889, DOI 10.1523/JNEUROSCI.0468-04.2004 Etherton M, 2011, P NATL ACAD SCI USA, V108, P13764, DOI 10.1073/pnas.1111093108 Etherton MR, 2011, EMBO J, V30, P2908, DOI 10.1038/emboj.2011.182 Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106 Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136 Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011 Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x Powell CM, 2004, NEURON, V42, P143, DOI 10.1016/S0896-6273(04)00146-1 Powell SB, 1999, PHYSIOL BEHAV, V66, P355, DOI 10.1016/S0031-9384(98)00303-5 Spencer CM, 2011, AUTISM RES, V4, P40, DOI 10.1002/aur.168 Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221 Yan J, 2005, MOL PSYCHIATR, V10, P329, DOI 10.1038/sj.mp.4001629 NR 18 TC 3 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD APR PY 2014 VL 7 IS 2 BP 264 EP 272 DI 10.1002/aur.1362 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AE9WD UT WOS:000334361200009 PM 24619977 ER PT J AU Lucchina, L Depino, AM AF Lucchina, Luciana Mara Depino, Amaicha TI Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism SO AUTISM RESEARCH LA English DT Article DE microglia; astroglia; behavior; cytokines; hypothalamus-pituitary-adrenal axis; valproic acid ID SPECTRUM DISORDERS; VALPROIC ACID; MICROGLIAL ACTIVATION; ANIMAL-MODEL; MICE; CHILDREN; BEHAVIOR; DEPRESSION; EXPOSURE; SYSTEM AB Increasing clinical and experimental evidence links immune and inflammatory alterations with the pathogenesis of autism spectrum disorders (ASD). Autistic individuals show signs of neuroinflammation, altered inflammatory responses, and immune abnormalities throughout life. Mice injected subcutaneously with 600 mg/kg valproic acid (VPA600) at gestational day 12.5 show reduced social interaction in adulthood (at 8 weeks of age), and they have been proposed as a mouse model of autism. Here, we show that these adult animals present signs of chronic glial activation in the hippocampus and the cerebellum. Moreover, when they are challenged with a peripheral inflammatory stimulus (intraperitoneal lipopolysaccharides, LPS), VPA600 animals show an exacerbated inflammatory response. Two hours after LPS injection, VPA600 animals secrete more corticosterone to the blood than control mice, and show an increase in the levels of expression of proinflammatory cytokines in the spleen. After LPS challenge, VPA600 mice also show signs of increased neuroinflammation compared with control mice: they have more microglial cells in the hippocampus, and they show higher levels of proinflammatory cytokines in the cerebellum. Our results provide evidence of basal neuroinflammation and an altered inflammatory response in the VPA model of autism. We propose that this model can be used to evaluate the contribution of inflammatory reactivity to autism-related behaviors. These studies will contribute to elucidate the role of the inflammatory alterations observed in ASD individuals. Autism Res 2013, 7: 273-289. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Mara Depino, Amaicha] CONICET UBA, Inst Physiol Mol Biol & Neurosci, Buenos Aires, DF, Argentina. Univ Buenos Aires, FCEyN, Dept Physiol Mol & Cellular Biol, Buenos Aires, DF, Argentina. RP Depino, AM (reprint author), CONICET UBA, Inst Physiol Mol Biol & Neurosci, Int Guiraldes S-N,Ciudad Univ,Pabellon 2,2Do Piso, Buenos Aires, DF, Argentina. EM adepino@conicet.gov.ar FU CONICET [PIP2010-2012]; University of Buenos Aires [UBACyT GEF2010-2012]; ANPCyT [PICT2010-1334] FX This work was supported by a CONICET Grant PIP2010-2012, a University of Buenos Aires Grant UBACyT GEF2010-2012, and an ANPCyT Grant PICT2010-1334. A. M. D. is a member of the Research Career of the National Council of Scientific and Technological Research (CONICET), Argentina. L. L. is fellow of the CONICET. We would like to thank Dr. Fernando Pitossi for his support at the beginning of this project and the access to the StereoInvestigation equipment, and Dr. Lucia Chemes for critical reading of the manuscript. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Silva AJ, 1997, NEURON, V19, P755, DOI 10.1016/S0896-6273(00)80958-7 Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003 Carola V, 2006, GENES BRAIN BEHAV, V5, P189, DOI 10.1111/j.1601-183X.2005.00152.x Centers for Disease Control and Prevention, 2009, PREV AUT SPECTR DIS Corbett BA, 2006, PSYCHONEUROENDOCRINO, V31, P59, DOI 10.1016/j.psyneuen.2005.05.011 COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102 Croonenberghs J, 2002, NEUROPSYCHOBIOLOGY, V45, P1, DOI 10.1159/000048665 Cryan JF, 2004, MOL PSYCHIATR, V9, P326, DOI 10.1038/sj.mp.4001457 DeLorey TM, 2008, BEHAV BRAIN RES, V187, P207, DOI 10.1016/j.bbr.2007.09.009 Depino A, 2005, J NEUROIMMUNOL, V168, P96, DOI 10.1016/j.jneuroim.2005.07.009 Depino AM, 2013, MOL CELL NEUROSCI, V53, P69, DOI 10.1016/j.mcn.2012.10.003 Depino AM, 2008, BRAIN RES, V1210, P189, DOI 10.1016/j.brainres.2008.03.006 Depino AM, 2011, BRAIN BEHAV IMMUN, V25, P1582, DOI 10.1016/j.bbi.2011.05.007 Enstrom AM, 2010, BRAIN BEHAV IMMUN, V24, P64, DOI 10.1016/j.bbi.2009.08.001 Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012 Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35 Hornig M, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003140 Howard CV, 2005, UNBIASED STEREOLOGY Hsiao EY, 2012, P NATL ACAD SCI USA, V109, P12776, DOI 10.1073/pnas.1202556109 Jyonouchi H, 2001, J NEUROIMMUNOL, V120, P170, DOI 10.1016/S0165-5728(01)00421-0 Kataoka S, 2013, INT J NEUROPSYCHOPH, V16, P91, DOI 10.1017/S1461145711001714 Kim KC, 2011, TOXICOL LETT, V201, P137, DOI 10.1016/j.toxlet.2010.12.018 Kreutzberg GW, 1996, TRENDS NEUROSCI, V19, P312, DOI 10.1016/0166-2236(96)10049-7 Lainhart JE, 1999, INT REV PSYCHIATR, V11, P278, DOI 10.1080/09540269974177 Lucchina L, 2010, BEHAV BRAIN RES, V213, P56, DOI 10.1016/j.bbr.2010.04.032 Malik M, 2011, IMMUNOBIOLOGY, V216, P80, DOI 10.1016/j.imbio.2010.03.001 Malkova NV, 2012, BRAIN BEHAV IMMUN, V26, P607, DOI 10.1016/j.bbi.2012.01.011 Martin LA, 2010, EUR J NEUROSCI, V31, P544, DOI 10.1111/j.1460-9568.2009.07073.x McCusker RH, 2013, J EXP BIOL, V216, P84, DOI 10.1242/jeb.073411 Moore SJ, 2000, J MED GENET, V37, P489, DOI 10.1136/jmg.37.7.489 Morgan JT, 2010, BIOL PSYCHIAT, V68, P368, DOI 10.1016/j.biopsych.2010.05.024 Onore C, 2012, BRAIN BEHAV IMMUN, V26, P383, DOI 10.1016/j.bbi.2011.08.007 Parracho HMRT, 2005, J MED MICROBIOL, V54, P987, DOI 10.1099/jmm.0.46101-0 Patterson PH, 2011, TRENDS MOL MED, V17, P389, DOI 10.1016/j.molmed.2011.03.001 Paxinos G, 2001, MOUSE BRAIN STEREOTA Pitossi F, 1997, J NEUROSCI RES, V48, P287, DOI 10.1002/(SICI)1097-4547(19970515)48:4<287::AID-JNR1>3.0.CO;2-7 Rasband W. S., 1997, IMAGEJ Rutter M, 2005, ACTA PAEDIATR, V94, P2, DOI 10.1080/08035250410023124 Schneider T, 2008, PSYCHONEUROENDOCRINO, V33, P728, DOI 10.1016/j.psyneuen.2008.02.011 Schneider T, 2005, NEUROPSYCHOPHARMACOL, V30, P80, DOI 10.1038/sj.npp.1300518 Shanks N, 2000, P NATL ACAD SCI USA, V97, P5645, DOI 10.1073/pnas.090571897 Shi LM, 2009, BRAIN BEHAV IMMUN, V23, P116, DOI 10.1016/j.bbi.2008.07.012 Spratt EG, 2012, J AUTISM DEV DISORD, V42, P75, DOI 10.1007/s10803-011-1214-0 Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013 Suzuki K, 2013, JAMA PSYCHIAT, V70, P49, DOI 10.1001/jamapsychiatry.2013.272 Tetreault NA, 2012, J AUTISM DEV DISORD, V42, P2569, DOI 10.1007/s10803-012-1513-0 Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315 Wagner GC, 2006, J AUTISM DEV DISORD, V36, P779, DOI 10.1007/s10803-006-0117-y Wang LW, 2011, J DEV BEHAV PEDIATR, V32, P351, DOI 10.1097/DBP.0b013e31821bd06a WEST MJ, 1991, ANAT REC, V231, P482, DOI 10.1002/ar.1092310411 Yirmiya R, 2011, BRAIN BEHAV IMMUN, V25, P181, DOI 10.1016/j.bbi.2010.10.015 NR 52 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD APR PY 2014 VL 7 IS 2 BP 273 EP 289 DI 10.1002/aur.1338 PG 17 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AE9WD UT WOS:000334361200010 PM 24124122 ER PT J AU Bailey, A AF Bailey, Anthony TI Autism Treatment Research SO AUTISM RESEARCH LA English DT Editorial Material C1 Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada. RP Bailey, A (reprint author), Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada. RI Bailey, Anthony/J-2860-2014 OI Bailey, Anthony/0000-0003-4257-972X NR 0 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 1 EP 3 DI 10.1002/aur.1358 PG 3 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300001 PM 24478272 ER PT J AU Corbett, BA Swain, DM Coke, C Simon, D Newsom, C Houchins-Juarez, N Jenson, A Wang, L Song, YN AF Corbett, Blythe A. Swain, Deanna M. Coke, Catherine Simon, David Newsom, Cassandra Houchins-Juarez, Nea Jenson, Ashley Wang, Lily Song, Yanna TI Improvement in Social Deficits in Autism Spectrum Disorders Using a Theatre-Based, Peer-Mediated Intervention SO AUTISM RESEARCH LA English DT Article DE autism; social interaction; face processing; theatre; cortisol ID PERVASIVE DEVELOPMENTAL DISORDERS; SKILLS INTERVENTIONS; ASPERGER-SYNDROME; PARENTING STRESS; CHILDREN; CORTISOL; BEHAVIOR; CLASSIFICATION; COMMUNICATION; METAANALYSIS AB Social Emotional NeuroScience Endocrinology Theatre is a novel intervention program aimed at improving reciprocal social interaction in youth with autism spectrum disorder (ASD) using behavioral strategies and theatrical techniques in a peer-mediated model. Previous research using a 3-month model showed improvement in face perception, social interaction, and reductions in stress. The current study assessed a 2-week summer camp model. Typically developing peers were trained and paired with ASD youth (8-17 years). Social perception and interaction skills were measured before and after treatment using neuropsychological and parental measures. Behavioral coding by reliable, independent raters was conducted within the treatment context (theatre) and outside the setting (playground). Salivary cortisol levels to assess physiological arousal were measured across contexts (home, theatre, and playground). A pretest-posttest design for within-group comparisons was used, and prespecified pairwise comparisons were achieved using a nonparametric Wilcoxon signed-rank test. Significant differences were observed in face processing, social awareness, and social cognition (P<0.05). Duration of interaction with familiar peers increased significantly over the course of treatment (P<0.05), while engagement with novel peers outside the treatment setting remained stable. Cortisol levels rose on the first day of camp compared with home values yet declined by the end of treatment and further reduced during posttreatment play with peers. Results corroborate previous findings that the peer-mediated theatre program contributes to improvement in core social deficits in ASD using a short-term, summer camp treatment model. Future studies will explore treatment length and peer familiarity to optimize and generalize gains. Autism Res 2014,7: 4-16. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Corbett, Blythe A.; Swain, Deanna M.; Simon, David; Newsom, Cassandra; Jenson, Ashley] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37203 USA. [Corbett, Blythe A.; Swain, Deanna M.; Simon, David; Newsom, Cassandra; Houchins-Juarez, Nea; Wang, Lily] Vanderbilt Kennedy Ctr, Nashville, TN USA. [Coke, Catherine] Univ Sch Nashville, Nashville, TN USA. [Wang, Lily; Song, Yanna] Vanderbilt Univ, Dept Biostat, Nashville, TN 37203 USA. RP Corbett, BA (reprint author), Vanderbilt Univ, PMB 40,230 Appleton Pl, Nashville, TN 37203 USA. EM blythe.corbett@vanderbilt.edu FU Martin McCoy-Jesperson Discovery Grant in Positive Psychology; National Institute of Mental Health [R01 MH085717]; National Institute of Child Health and Human Development [P30 HD15052] FX Grant Sponsor: Martin McCoy-Jesperson Discovery Grant in Positive PsychologyGrant Sponsor: National Institute of Mental Health; Grant Number: R01 MH085717Grant Sponsor: National Institute of Child Health and Human Development; Grant Number: P30 HD15052 CR Abidin R. R., 2003, PARENTING STRESS IND Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289 (APA) APA, 2000, DIAGN STAT MAN MENT Ballon JS, 2007, PSYCHIAT RES, V151, P29, DOI 10.1016/j.psychres.2006.10.012 Bauminger N, 2007, J AUTISM DEV DISORD, V37, P1605, DOI 10.1007/s10803-006-0246-3 BELCHIC JK, 1994, CHILD FAM BEHAV THER, V16, P1, DOI 10.1300/J019v16n02_01 Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201 Cashin Andrew, 2013, J Child Adolesc Psychiatr Nurs, V26, P32, DOI 10.1111/jcap.12020 Charlop-Christy MH, 2000, J AUTISM DEV DISORD, V30, P537, DOI 10.1023/A:1005635326276 Cohen J., 1988, STAT POWER ANAL BEHA, V2nd Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2 Constantino JN, 2005, SOCIAL RESPONSIVENES Corbett B., 2003, BEHAV ANAL TODAY, V4, P367 Corbett B. A., 2012, MOL AUTISM, V3, P1 Corbett B. A., 2005, J EARLY INTENSIVE BE, V2, P2 Corbett BA, 2011, J AUTISM DEV DISORD, V41, P505, DOI 10.1007/s10803-010-1064-1 Corbett B.A., 2010, MOL AUTISM, V1, P1 Corbett BA, 2008, J PSYCHIATR NEUROSCI, V33, P227 Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005 Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203 Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z DiSalvo C., 2002, FOCUS AUTISM OTHER D, V17, P198, DOI DOI 10.1177/10883576020170040201 Dow AW, 2007, J GEN INTERN MED, V22, P1114, DOI 10.1007/s11606-007-0224-2 Dunlap WP, 1996, PSYCHOL METHODS, V1, P170, DOI 10.1037//1082-989X.1.2.170 Faja S, 2012, J AUTISM DEV DISORD, V42, P278, DOI 10.1007/s10803-011-1243-8 GOLDSTEIN H, 1992, J APPL BEHAV ANAL, V25, P265, DOI 10.1901/jaba.1992.25-265 Goldstein TR, 2011, MIND BRAIN EDUC, V5, P97, DOI 10.1111/j.1751-228X.2011.01115.x GRESHAM FM, 1986, J CLIN CHILD PSYCHOL, V15, P3, DOI 10.1207/s15374424jccp1501_1 Guli L. A., 2004, THESIS U TEXAS AUSTI Guli LA, 2013, ART PSYCHOTHER, V40, P37, DOI 10.1016/j.aip.2012.09.002 Hall Heather R, 2011, Issues Compr Pediatr Nurs, V34, P4, DOI 10.3109/01460862.2011.555270 Harrison P. L., 2000, ADAPTIVE BEHAV ASSES Hayes SA, 2013, J AUTISM DEV DISORD, V43, P629, DOI 10.1007/s10803-012-1604-y Jansen LMC, 2003, NEUROPSYCHOPHARMACOL, V28, P582, DOI 10.1038/sj.npp.1300046 Kamps D, 2002, EXCEPT CHILDREN, V68, P173 Knott F, 2006, AUTISM, V10, P609, DOI 10.1177/1362361306068510 Koegel LK, 2012, BEHAV MODIF, V36, P361, DOI 10.1177/0145445512445609 Korkman M., 2007, NEPSY Krasny L, 2003, CHILD ADOL PSYCH CL, V12, P107, DOI 10.1016/S1056-4993(02)00051-2 Lanni KE, 2012, AUTISM, V16, P123, DOI 10.1177/1362361311425916 Lerner MD, 2011, AUTISM, V15, P21, DOI 10.1177/1362361309353613 Levine TP, 2012, RES AUTISM SPECT DIS, V6, P177, DOI 10.1016/j.rasd.2011.04.003 Lopata C, 2008, J AUTISM DEV DISORD, V38, P1866, DOI 10.1007/s10803-008-0575-5 Lord C., 1999, AUTISM DIAGNOSTIC OB McCarron PA, 1988, EARLY CHILD DEV CARE, V33, P113, DOI 10.1080/0300443880330109 Nigg CR, 2002, HEALTH EDUC RES, V17, P670, DOI 10.1093/her/17.5.670 Nikopoulos CK, 2007, J AUTISM DEV DISORD, V37, P678, DOI 10.1007/s10803-006-0195-x Noldus, 2008, OBS XT, V10 ODOM SL, 1984, AM J ORTHOPSYCHIAT, V54, P544 Paul R, 2008, CHILD ADOL PSYCH CL, V17, P835, DOI 10.1016/j.chc.2008.06.011 Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059 Pierce K, 1997, J APPL BEHAV ANAL, V30, P157, DOI 10.1901/jaba.1997.30-157 PIERCE K, 1995, J APPL BEHAV ANAL, V28, P285, DOI 10.1901/jaba.1995.28-285 Reichow B, 2010, J AUTISM DEV DISORD, V40, P149, DOI 10.1007/s10803-009-0842-0 Rutter M., 2003, SOCIAL COMMUNICATION Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331 Schupp CW, 2013, J AUTISM DEV DISORD, V43, P2405, DOI 10.1007/s10803-013-1790-2 Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x Viau R, 2010, PSYCHONEUROENDOCRINO, V35, P1187, DOI 10.1016/j.psyneuen.2010.02.004 Warren SF, 2007, MENT RETARD DEV D R, V13, P70, DOI 10.1002/mrdd.20139 Wechsler D, 1999, WECHSLER ABBREVIATED WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288 Wink LK, 2010, CURR TREAT OPTION NE, V12, P529, DOI 10.1007/s11940-010-0091-8 Yerkes RM, 1908, J COMP NEUROL PSYCHO, V18, P459, DOI 10.1002/cne.920180503 NR 64 TC 4 Z9 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 4 EP 16 DI 10.1002/aur.1341 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300002 PM 24150989 ER PT J AU Louwerse, A Tulen, JHM van der Geest, JN van der Ende, J Verhulst, FC Greaves-Lord, K AF Louwerse, Anneke Tulen, Joke H. M. van der Geest, Jos N. van der Ende, Jan Verhulst, Frank C. Greaves-Lord, Kirstin TI Autonomic Responses to Social and Nonsocial Pictures in Adolescents With Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders (ASD); affective pictures; autonomic responses; subjective ratings; heart rate; skin conductance level ID DIAGNOSTIC OBSERVATION SCHEDULE; HIGH-FUNCTIONING AUTISM; ELECTRODERMAL REACTIVITY; PHYSIOLOGICAL REACTIVITY; CHILDREN; EMOTION; FACES; PERCEPTION; GAZE; COMMUNICATION AB It remains unclear why individuals with autism spectrum disorder (ASD) tend to respond in an atypical manner in social situations. Investigating autonomic and subjective responses to social vs. nonsocial stimuli may help to reveal underlying mechanisms of these atypical responses. This study examined autonomic responses (skin conductance level and heart rate) and subjective responses to social vs. nonsocial pictures in 37 adolescents with an ASD and 36 typically developing (TD) adolescents. Thirty-six pictures from the International Affective Picture System were presented, divided into six categories based on social content (social vs. nonsocial) and pleasantness (pleasant, neutral, and unpleasant). Both in adolescents with ASD as well as TD adolescents, pictures with a social content resulted in higher skin conductance responses (SCRs) for pleasant and unpleasant pictures than for neutral pictures. No differences in SCRs were found for the three nonsocial picture categories. Unpleasant pictures, both with and without a social content, showed more heart rate deceleration than neutral pictures. Self-reported arousal ratings were influenced by the social and affective content of a picture. No differences were found between individuals with ASD and TD individuals in their autonomic and subjective responses to the picture categories. These results suggest that adolescents with ASD do not show atypical autonomic or subjective responses to pictures with and without a social content. These findings make it less likely that impairments in social information processing in individuals with ASD can be explained by atypical autonomic responses to social stimuli. Autism Res 2014, 7: 17-27. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Louwerse, Anneke; van der Ende, Jan; Verhulst, Frank C.; Greaves-Lord, Kirstin] Erasmus MC Sophia, Dept Child & Adolescent Psychiat Psychol, NL-3015 CN Rotterdam, Netherlands. [Louwerse, Anneke; Greaves-Lord, Kirstin] Yulius, Org Mental Hlth, Dordrecht, Netherlands. [Tulen, Joke H. M.] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands. [van der Geest, Jos N.] Erasmus MC, Dept Neurosci, Rotterdam, Netherlands. RP Louwerse, A (reprint author), Erasmus MC Sophia, Dept Child & Adolescent Psychiat Psychol, Wytemaweg 8, NL-3015 CN Rotterdam, Netherlands. EM s.louwerse@erasmusmc.nl FU Sophia Foundation for Scientific Research (SSWO) [586]; Nuts Ohra Foundation [0803-53] FX Grant sponsor: Sophia Foundation for Scientific Research (SSWO), Grant number: 586, 2009.Grant sponsor: Nuts Ohra Foundation, Grant number: 0803-53. CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289 Alpers GW, 2011, INT J PSYCHOPHYSIOL, V80, P173, DOI 10.1016/j.ijpsycho.2011.01.010 (APA) APA, 2000, DIAGN STAT MAN MENT Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3 Bastiaansen JA, 2011, J AUTISM DEV DISORD, V41, P1256, DOI 10.1007/s10803-010-1157-x Ben Shalom D, 2006, J AUTISM DEV DISORD, V36, P395, DOI 10.1007/s10803-006-0077-2 Bildt A., 2013, J AUTISM DEV DISORDE, DOI 10.1007/s10803-013-1793-1 Bolte S, 2008, J AUTISM DEV DISORD, V38, P776, DOI 10.1007/s10803-007-0443-8 Bradley MM, 2001, EMOTION, V1, P276, DOI 10.1037//1528-3542.1.3.276 BRADLEY MM, 2000, SER AFFECTIVE SCI, P242 Chawarska K, 2009, J AUTISM DEV DISORD, V39, P1663, DOI 10.1007/s10803-009-0803-7 Cohen J., 1988, STAT POWER ANAL BEHA, V2nd Coull JT, 1998, PROG NEUROBIOL, V55, P343, DOI 10.1016/S0301-0082(98)00011-2 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Daluwatte C., 2012, J AUTISM DEV DISORD, V43, P1910, DOI DOI 10.1007/S10803-012-1741-3 Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Greaves-Lord K, 2007, J AFFECT DISORDERS, V102, P55, DOI 10.1016/j.jad.2006.12.009 Hadjikhani N, 2007, HUM BRAIN MAPP, V28, P441, DOI 10.1002/hbm.20283 Hajcak G., 2011, BIOL PSYCHOL, V92, P447, DOI 10.1016/j.biopsycho.2011.11.012 Hartman CA, 2006, J AUTISM DEV DISORD, V36, P325, DOI 10.1007/s10803-005-0072-z Hempel RJ, 2007, INT J PSYCHOPHYSIOL, V64, P174, DOI 10.1016/j.ijpsycho.2007.01.008 Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724 Hubert BE, 2009, AUTISM, V13, P9, DOI 10.1177/1362361308091649 Hutt C., 1964, NATURE, V204 Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344 Kaartinen M, 2012, J AUTISM DEV DISORD, V42, P1917, DOI 10.1007/s10803-011-1435-2 Kleinhans NM, 2011, NEUROIMAGE, V54, P697, DOI 10.1016/j.neuroimage.2010.07.037 Kliemann D, 2012, J NEUROSCI, V32, P9469, DOI 10.1523/JNEUROSCI.5294-11.2012 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 Kylliainen A, 2012, J CHILD PSYCHOL PSYC, V53, P790, DOI 10.1111/j.1469-7610.2011.02522.x Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4 Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465 Lang N. J., 2007, EUROPEAN CHILD ADOLE, V16, P71 Lang P. J., 1988, INT AFFECTIVE PICTUR Lang P. J., 2001, A5 CTR RES PSYCH LANG PJ, 1993, PSYCHOPHYSIOLOGY, V30, P261, DOI 10.1111/j.1469-8986.1993.tb03352.x Lang PJ, 1998, J CLIN NEUROPHYSIOL, V15, P397, DOI 10.1097/00004691-199809000-00004 Levine TP, 2012, RES AUTISM SPECT DIS, V6, P177, DOI 10.1016/j.rasd.2011.04.003 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Mathersul D., 2012, PHYSL BEHAV C, V109C, P14 Mathewson KJ, 2011, AUTISM RES, V4, P98, DOI 10.1002/aur.176 Oberman LM, 2009, DEVELOPMENTAL SCI, V12, P510, DOI 10.1111/j.1467-7687.2008.00796.x Osborne J., 2010, PRACTICAL ASSESSMENT OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225 Phillips ML, 2003, BIOL PSYCHIAT, V54, P515, DOI 10.1016/S0006-3223(03)00171-9 Riby DM, 2012, J CLIN EXP NEUROPSYC, V34, P385, DOI 10.1080/13803395.2011.645019 Riby DM, 2009, J AUTISM DEV DISORD, V39, P421, DOI 10.1007/s10803-008-0641-z Rice K, 2012, J AM ACAD CHILD PSY, V51, P238, DOI 10.1016/j.jaac.2011.12.017 RIMLAND B, 1968, ACTA PAEDOPSYCHIATR, V35, P146 Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x Rutter M., 2003, AUTISM DIAGNOSTIC IN Sasson N. J., 2012, PLOS ONE, V7 Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001 Sigman M, 2003, AUTISM, V7, P205, DOI 10.1177/1362361303007002007 Sung YJ, 2005, AM J HUM GENET, V76, P68, DOI 10.1086/426951 Tick NT, 2008, EUR CHILD ADOLES PSY, V17, P373, DOI 10.1007/s00787-008-0679-7 Turpin G, 1999, PSYCHOPHYSIOLOGY, V36, P453, DOI 10.1017/S0048577299971974 VANENGELAND H, 1991, PSYCHIAT RES, V38, P27, DOI 10.1016/0165-1781(91)90050-Y Wechsler D, 1999, WECHSLER ABBREVIATED NR 60 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 17 EP 27 DI 10.1002/aur.1327 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300003 PM 24022989 ER PT J AU Custance, DM Mayer, JL Kumar, E Hill, E Heaton, PF AF Custance, Deborah M. Mayer, Jennifer L. Kumar, Emmelianna Hill, Elisabeth Heaton, Pamela F. TI Do Children With Autism Re-Enact Object Movements Rather Than Imitate Demonstrator Actions? SO AUTISM RESEARCH LA English DT Article DE autism; imitation; emulation; transitive ID SPECTRUM DISORDERS; DIAGNOSTIC INTERVIEW; MOTOR IMITATION; INFANTS; DEFICITS; TASK; APES; MIND AB It has been suggested that autism-specific imitative deficits may be reduced or even spared in object-related activities. However, most previous research has not sufficiently distinguished object movement reenactment (learning about the ways in which object move) from imitation (learning about the topography of demonstrated actions). Twenty children with autism (CWA) and 20 typically developing children (TDC) were presented with puzzle boxes containing prizes. Test objects and experimental conditions were designed to isolate object- and action-related aspects of demonstrations. There were four types of video demonstrations: (a) a full demonstration by an adult; (b) a ghost demonstration with object movements alone; (c) mimed solutions demonstrated adjacent to the objects; and (d) random actions performed on the surface of the objects. There were no significant between-group differences in the degree to which CWA and TDC matched the full demonstrations, the actual demonstrations or in their times to first solution in any of the conditions. Although there was no clear imitative deficit in the CWA, regression analyses were conducted to explore in more detail whether diagnosis, verbal intelligence quotient (VIQ), nonverbal IQ NVIQ, age or motor coordination predicted performance. The results are discussed in relation to the use of extrinsic vs. intrinsic rewards and the interplay between motor coordination and the relative rigidity vs. pliability of objects. Autism Res 2014, 7: 28-39. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Custance, Deborah M.; Hill, Elisabeth; Heaton, Pamela F.] Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England. [Mayer, Jennifer L.] Univ Roehampton, Dept Psychol, Whitelands Coll, London SW15 4JD, England. [Kumar, Emmelianna] Zool Soc London, Inst Zool, London NW1 4RY, England. RP Mayer, JL (reprint author), Univ Roehampton, Dept Psychol, Whitelands Coll, Holyborne Ave, London SW15 4JD, England. EM jennifer.mayer@roehampton.ac.uk FU Economic and Social Research Council [RES-00022-2006] FX This research was carried out with the support of the Economic and Social Research Council (award reference number RES-00022-2006). We are very grateful to all the schools, children and parents who participated in our experiments. We are indebted to Mr. Stephen Yesson and Mr. Robert Davis for constructing the test objects, Mrs. Vivienne Custance and Dr Lisa Riley for helping in data collection, and Ms. Elisabeth Martinsson and Mrs. Katherine Filer for interobserver reliability coding. We would like to thank Dr. Rory Allen for offering his statistical expertise. We are also grateful to the reviewers who provided extremely helpful and insightful commentaries on earlier versions of this paper. CR American Psychiatric Association, 2000, DSM 4 TR DIAGN STAT, VFourth Bhat AN, 2011, PHYS THER, V91, P1116, DOI 10.2522/ptj.20100294 Bird G, 2007, P ROY SOC B-BIOL SCI, V274, P3027, DOI 10.1098/rspb.2007.1019 Bruininks R. H., 2005, BRUININKS OSERETSKY CALL J, 2002, COM ADAP SY, P211 Custance D, 1999, J COMP PSYCHOL, V113, P13, DOI 10.1037/0735-7036.113.1.13 D'Sousa L., 2004, THESIS GOLDSMITHS CO Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd Fawcett TW, 2002, ANIM BEHAV, V64, P547, DOI 10.1006/anbe.2002.3092 Fournier KA, 2010, J AUTISM DEV DISORD, V40, P1227, DOI 10.1007/s10803-010-0981-3 Gergely G, 2002, NATURE, V415, P755 Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054 Hamilton AFD, 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI 10.1016/j.neuropsychologia.2006.11.022 HAPPE FGE, 1993, COGNITION, V48, P101, DOI 10.1016/0010-0277(93)90026-R Henderson S. E., 2007, MOVEMENTASSESSMENTBA HEYES CM, 1993, ANIM BEHAV, V46, P999, DOI 10.1006/anbe.1993.1281 Hobson RP, 2008, J EXP CHILD PSYCHOL, V101, P170, DOI 10.1016/j.jecp.2008.04.007 Hobson RP, 1999, J CHILD PSYCHOL PSYC, V40, P649, DOI 10.1111/1469-7610.00481 Hopper LM, 2010, BIOL REV, V85, P685, DOI 10.1111/j.1469-185X.2010.00120.x Hopper LM, 2010, J EXP CHILD PSYCHOL, V106, P82, DOI 10.1016/j.jecp.2009.12.001 Humayun S., 2006, THESIS GOLDSMITHS CO Ingersoll B, 2008, RES AUTISM SPECT DIS, V2, P332, DOI 10.1016/j.rasd.2007.08.003 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 McDuffie A, 2007, J AUTISM DEV DISORD, V37, P401, DOI 10.1007/s10803-006-0175-1 Meltzoff A. N., 1993, UNDERSTANDING OTHER, P335 Meltzoff A. N, 2005, PERSPECTIVES IMITATI, V2, P55 MELTZOFF AN, 1985, CHILD DEV, V56, P62, DOI 10.1111/j.1467-8624.1985.tb00086.x Nielsen M, 2010, AUST J PSYCHOL, V62, P67, DOI 10.1080/00049530902758613 Perra O, 2008, RES AUTISM SPECT DIS, V2, P456, DOI 10.1016/j.rasd.2007.09.007 Raven J., 1998, RAVEN MANUAL STANDAR Receveur C, 2005, AUTISM, V9, P69, DOI 10.1177/1362361305049030 Rogers S. J., 1999, IMITATION INFANCY, P254 Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043 Rogers SJ, 2010, DEV PSYCHOPATHOL, V22, P71, DOI 10.1017/S0954579409990277 Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008 Spence KW, 1937, PSYCHOL BULL, V34, P806, DOI 10.1037/h0061498 Subiaul F., 2011, PLOS ONE, V6 Tennie C, 2006, ETHOLOGY, V112, P1159, DOI 10.1111/j.1439-0310.2006.01269.x Vanvuchelen M, 2007, AUTISM, V11, P225, DOI 10.1177/1362361307076846 Vanvuchelen M, 2011, J AUTISM DEV DISORD, V41, P484, DOI 10.1007/s10803-010-1074-z Whiten A., 1992, ADV STUD BEHAV, P239 Whiten A., 1998, INTERSUBJECTIVE COMM, P260 Whiten A, 2004, LEARN BEHAV, V32, P36 Whiten A, 1996, J COMP PSYCHOL, V110, P3, DOI 10.1037//0735-7036.110.1.3 Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a Young GS, 2011, DEV PSYCHOL, V47, P1565, DOI 10.1037/a0025418 Zachor DA, 2010, RES AUTISM SPECT DIS, V4, P438, DOI 10.1016/j.rasd.2009.10.016 NR 49 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 28 EP 39 DI 10.1002/aur.1328 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300004 PM 24022995 ER PT J AU Mayer, JL Heaton, PF AF Mayer, Jennifer L. Heaton, Pamela F. TI Age and Sensory Processing Abnormalities Predict Declines in Encoding and Recall of Temporally Manipulated Speech in High-Functioning Adults with ASD SO AUTISM RESEARCH LA English DT Article DE Autism Spectrum Disorders; Speech Perception; Auditory Processing; Aging ID AUTISM SPECTRUM DISORDERS; EVENT-RELATED POTENTIALS; BRAIN-STEM RESPONSE; ASPERGER-SYNDROME; RAPID SPEECH; CHILDREN; PERCEPTION; TIME; ATTENTION; SOUNDS AB While temporal and perceptual processing abnormalities, identified in a number of electrophysiological and brain imaging studies of individuals with (ASD), are likely to impact on speech perception, surprisingly little is known about the behavioral outcomes of such abnormalities. It has been hypothesized that rapid temporal processing deficits may be linked to impaired language development through interference with acoustic information during speech perception. The present study aimed to investigate the impact of temporal changes on encoding and recall of speech, and the associated cognitive, clinical, and behavioral correlates in adults with ASD. Research carried out with typically developing (TD) adults has shown that word recall diminishes as the speed of speech increases, and it was predicted that the magnitude of this effect would be far greater in those with ASD because of a preexisting rapid temporal processing deficit. Nineteen high-functioning adults with ASD, and age- and intelligence-matched TD controls performed verbatim recall of temporally manipulated sentences. Reduced levels of word recall in response to increases in presentation speed were observed, and this effect was greater in the older participants in the ASD group than in the control group. This is the first study to show that both sensory abnormalities and aging impact on speech encoding in ASD. Auditory processing deficits in ASD may be indicative of an association with the sensory abnormalities and social and communication impairments characterizing the disorder. Autism Res 2014, 7: 40-49. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Mayer, Jennifer L.] Univ Roehampton, Dept Psychol, London SW15 4JD, England. [Heaton, Pamela F.] Univ London, Univ London Goldsmiths Coll, Dept Psychol, London, England. RP Mayer, JL (reprint author), Univ Roehampton, Dept Psychol, Whitelands Coll, Holyborne Ave, London SW15 4JD, England. EM jennifer.mayer@roehampton.ac.uk FU Baily Thomas Trust FX This research was carried out with the support of the Baily Thomas Trust. We are very grateful to all the ASD and TD adults who participated in our study. We would also like to thank Mr. Ian Hannett for his assistance creating the stimuli. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Bishop D. V. M., 2009, COMMUNICATION CHECKL Boersma P., 2001, PRAAT SYSTEM DOING P Cardy JEO, 2005, NEUROREPORT, V16, P329 Crane L, 2009, AUTISM, V13, P215, DOI 10.1177/1362361309103794 Doyle-Thomas KAR, 2013, RES AUTISM SPECT DIS, V7, P141, DOI 10.1016/j.rasd.2012.08.004 Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd Dunn W., 2002, ADULT ADOLESCENT SEN Fujikawa-Brooks S, 2010, INT J AUDIOL, V49, P129, DOI 10.3109/14992020903289790 Gepner B, 2009, NEUROSCI BIOBEHAV R, V33, P1227, DOI 10.1016/j.neubiorev.2009.06.006 Gepner B., 2006, FRONTIERS COGNITIVE, P1 Gervais H, 2004, NAT NEUROSCI, V7, P801, DOI 10.1038/nn1291 Gillberg C., 2000, BIOL AUTISTIC SYNDRO Howlin P, 2005, AUTISM, V9, P533, DOI 10.1177/1362361305057871 Janse E, 2004, SPEECH COMMUN, V42, P155, DOI 10.1016/j.specom.2003.07.001 Kallstrand J, 2010, NEUROPSYCH DIS TREAT, V6, P289 Klinger L., 2002, CHILD PSYCHOPATHOLOG, P409 Kujala T, 2000, PSYCHOPHYSIOLOGY, V37, P262 Kwakye L. D., 2011, FRONTIERS INTEGRATIV, V4, P1, DOI [10.3389/fnint.2010.00129, DOI 10.3389/FNINT.2010.00129] Laine F., 2009, ENFANCE, V1, P133 Laine F., 2008, AUT NEUR C ROYAL SOC Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7 Lepisto T, 2006, CLIN NEUROPHYSIOL, V117, P2161, DOI 10.1016/j.clinph.2006.06.709 Lepisto T, 2005, BRAIN RES, V1066, P147, DOI 10.1016/j.brainres.2005.10.052 Lepisto T, 2009, BIOL PSYCHOL, V82, P301, DOI 10.1016/j.biopsycho.2009.09.004 Lord C., 2001, AUTISM DIAGNOSTIC OB ROSEN S, 1992, PHILOS T ROY SOC B, V336, P367, DOI 10.1098/rstb.1992.0070 Stine E L, 1986, Psychol Aging, V1, P303, DOI 10.1037/0882-7974.1.4.303 Tardif C., 2002, PAROLE, V21, P35 TUN PA, 1992, PSYCHOL AGING, V7, P546, DOI 10.1037/0882-7974.7.4.546 Tun PA, 1998, PSYCHOL AGING, V13, P424, DOI 10.1037//0882-7974.13.3.424 Wallace GL, 2010, BRAIN, V133, P3745, DOI 10.1093/brain/awq279 Wechsler D., 2008, WECHSLER ADULT INTEL Wechsler D, 1999, WECHSLER ABBREVIATED Whitehouse AJO, 2008, DEVELOPMENTAL SCI, V11, P516, DOI 10.1111/j.1467-7687.2008.00697.x WINGFIELD A, 1975, J SPEECH HEAR RES, V18, P96 WINGFIELD A, 1985, J GERONTOL, V40, P579 NR 38 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 40 EP 49 DI 10.1002/aur.1333 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300005 PM 24106132 ER PT J AU Bebko, JM Schroeder, JH Weiss, JA AF Bebko, James M. Schroeder, Jessica H. Weiss, Jonathan A. TI The McGurk Effect in Children With Autism and Asperger Syndrome SO AUTISM RESEARCH LA English DT Article DE autism; intermodal perception; Asperger syndrome; intellectual disability; speech ID SPECTRUM DISORDERS; SPEECH-PERCEPTION; INTEGRATION; INFANTS; LIPS; FACE AB Children with autism may have difficulties in audiovisual speech perception, which has been linked to speech perception and language development. However, little has been done to examine children with Asperger syndrome as a group on tasks assessing audiovisual speech perception, despite this group's often greater language skills. Samples of children with autism, Asperger syndrome, and Down syndrome, as well as a typically developing sample, were presented with an auditory-only condition, a speech-reading condition, and an audiovisual condition designed to elicit the McGurk effect. Children with autism demonstrated unimodal performance at the same level as the other groups, yet showed a lower rate of the McGurk effect compared with the Asperger, Down and typical samples. These results suggest that children with autism may have unique intermodal speech perception difficulties linked to their representations of speech sounds. Autism Res 2014, 7: 50-59. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Bebko, James M.; Schroeder, Jessica H.; Weiss, Jonathan A.] York Univ, Toronto, ON M3J 1P3, Canada. RP Bebko, JM (reprint author), York Univ, Dept Psychol, 4700 Keele St, Toronto, ON M3J 1P3, Canada. EM jbebko@yorku.ca FU Canadian Graduate Scholarship Master's and Doctoral Awards; Canadian Institutes of Health Research (CIHR); Ontario Mental Health Foundation; CIHR [RT-43820] FX We would like to thank Nicole Aliya Rahim, Lisa Hancock, Carly McMorris, Maggie Slusarczyk, and Ksusha Blacklock for help in data collection. Special thanks to all the parents and children involved in this study, as well as the organizations who assisted in recruitment. A special thank you to Melissa Hudson, and the late Jeanette Holden for their generous assistance with the ASD-CARC Research Registry. This research was supported by Canadian Graduate Scholarship Master's and Doctoral Awards to the second author from the Canadian Institutes of Health Research (CIHR), a Research Studentship to the third author from Autism Ontario and the Ontario Mental Health Foundation, and a CIHR Interdisciplinary Health Research Team grant (RT-43820) to the second author and third author through the ASD-CARC consortium (JJAH, principal investigator; http://www.asdcarc.com/). CR AGRE, AFF STAT CAT American Psychiatric Association, 2000, DIAGN STAT MAN MENT American Psychiatric Association, 2013, DIAGN STAT MAN MENT Arick J. R., 2003, KRUG ASPERGERS DISOR Bebko JM, 2006, J CHILD PSYCHOL PSYC, V47, P88, DOI 10.1111/j.1469-7610.2005.01443.x Bennett T, 2008, J AUTISM DEV DISORD, V38, P616, DOI 10.1007/s10803-007-0428-7 Boucher J, 2000, J CHILD PSYCHOL PSYC, V41, P847, DOI 10.1017/S0021963099006149 Brownell R, 2000, EXPRESSIVE ONE WORD, V3rd Burnham D, 2004, DEV PSYCHOBIOL, V45, P204, DOI 10.1002/dev.20032 Campbell JM, 2005, J AUTISM DEV DISORD, V35, P25, DOI 10.1007/s10803-004-1028-4 Colin C, 2005, EUR J COGN PSYCHOL, V17, P541, DOI 10.1080/09541440440000168 De Gelder B, 1991, EUROPEAN J COGNITIVE, V3, P69, DOI 10.1080/09541449108406220 Desjardins RN, 1997, J EXP CHILD PSYCHOL, V66, P85, DOI 10.1006/jecp.1997.2379 Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd Fombonne E., 2005, HDB AUTISM PERVASIVE, V1, P42 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Iarocci G, 2010, AUTISM, V14, P305, DOI 10.1177/1362361309353615 Irwin JR, 2011, CHILD DEV, V82, P1397, DOI 10.1111/j.1467-8624.2011.01619.x Keane BP, 2010, RES AUTISM SPECT DIS, V4, P276, DOI 10.1016/j.rasd.2009.09.015 KLIN A, 1991, J AUTISM DEV DISORD, V21, P29, DOI 10.1007/BF02206995 Kuhl PK, 2005, DEVELOPMENTAL SCI, V8, pF1, DOI 10.1111/j.1467-7687.2004.00384.x KUHL PK, 1984, INFANT BEHAV DEV, V7, P361, DOI 10.1016/S0163-6383(84)80050-8 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Massaro D. W., 1998, PERCEIVING TALKING F Massaro DW, 2006, AUTISM, V10, P495, DOI 10.1177/1362361306066599 Massaro DW, 2000, J ACOUST SOC AM, V108, P784, DOI 10.1121/1.429611 MCGURK H, 1976, NATURE, V264, P746, DOI 10.1038/264746a0 Mongillo EA, 2008, J AUTISM DEV DISORD, V38, P1349, DOI 10.1007/s10803-007-0521-y Psychological Corporation, 1999, WECHSLER ABBREVIATED Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x Sattler J. M., 2001, ASSESSMENT CHILDREN Schopler E., 1992, CHILDHOOD AUTISM RAT SUMMERFIELD Q, 1984, Q J EXP PSYCHOL-A, V36, P51 Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008 NR 34 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 50 EP 59 DI 10.1002/aur.1343 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300006 PM 24136870 ER PT J AU Amiri, A Sanchez-Ortiz, E Cho, W Birnbaum, SG Xu, J McKay, RM Parada, LF AF Amiri, Anahita Sanchez-Ortiz, Efrain Cho, Woosung Birnbaum, Shari G. Xu, Jing McKay, Renee M. Parada, Luis F. TI Analysis of Fmr1 Deletion in a Subpopulation of Post-Mitotic Neurons in Mouse Cortex and Hippocampus SO AUTISM RESEARCH LA English DT Article DE Fragile X Syndrome; Fmr1; autism; mental retardation; Nse-Cre; synaptic plasticity ID FRAGILE-X-SYNDROME; MENTAL-RETARDATION PROTEIN; KNOCK-OUT MICE; GABA(A) RECEPTOR; SOCIAL-INTERACTION; DENDRITIC SPINES; PURKINJE-CELLS; MODEL; EXPRESSION; AUTISM AB Fragile X syndrome (FXS) is the most common form of inherited mental retardation and the leading cause of autism. FXS is caused by mutation in a single gene, FMR1, which encodes an RNA-binding protein FMRP. FMRP is highly expressed in neurons and is hypothesized to have a role in synaptic structure, function, and plasticity by regulating mRNAs that encode pre- and post-synaptic proteins. Fmr1 knockout (KO) mice have been used as a model to study FXS. These mice have been reported to show a great degree of phenotypic variability based on the genetic background, environmental signals, and experimental methods. In this study, we sought to restrict FMRP deletion to two brain regions that have been implicated in FXS and autism. We show that ablating Fmr1 in differentiated neurons of hippocampus and cortex results in dendritic alterations and changes in synaptic marker intensity that are brain region specific. In our conditional mutant mice, FMRP-deleted neurons have activated AKT-mTOR pathway signaling in hippocampus but display no apparent behavioral phenotypes. These results highlight the importance of identifying additional factors that interact with Fmr1 to develop FXS. AutismRes 2014, 7: 60-71. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. (c) 2013 INSAR/Wiley Periodicals, Inc. C1 [Amiri, Anahita; Sanchez-Ortiz, Efrain; Cho, Woosung; McKay, Renee M.; Parada, Luis F.] Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA. [Birnbaum, Shari G.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA. RP Parada, LF (reprint author), Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA. EM luis.parada@utsouthwestern.edu FU Simons Foundation FX We thank Ami Pettersen, Tracey Shipman, and Shawna Kennedy for technical assistance. This study was supported by a grant to LFP from the Simons Foundation. LFP is an American Cancer Society Professor. CR Amiri A, 2012, J NEUROSCI, V32, P5880, DOI 10.1523/JNEUROSCI.5462-11.2012 Barski JJ, 2000, GENESIS, V28, P93, DOI 10.1002/1526-968X(200011/12)28:3/4<93::AID-GENE10>3.0.CO;2-W Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009 Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646 Centonze D, 2008, BIOL PSYCHIAT, V63, P963, DOI 10.1016/j.biopsych.2007.09.008 Chen L, 2001, NEUROSCIENCE, V103, P1043, DOI 10.1016/S0306-4522(01)00036-7 Chiu S, 2007, J DEV BEHAV PEDIATR, V28, P31, DOI 10.1097/01.DBP.0000257518.60083.2d Chonchaiya Weerasak, 2009, Adv Pediatr, V56, P165, DOI 10.1016/j.yapd.2009.08.008 Comery TA, 1997, P NATL ACAD SCI USA, V94, P5401, DOI 10.1073/pnas.94.10.5401 BAKKER CE, 1994, CELL, V78, P23 Curia G, 2009, CEREB CORTEX, V19, P1515, DOI 10.1093/cercor/bhn159 Darnell JC, 2011, CELL, V146, P247, DOI 10.1016/j.cell.2011.06.013 D'Hulst C, 2006, BRAIN RES, V1121, P238, DOI 10.1016/j.brainres.2006.08.115 D'Hulst C, 2007, TRENDS NEUROSCI, V30, P425, DOI 10.1016/j.tins.2007.06.003 D'Hulst C, 2009, DRUG DISCOV TODAY, V14, P866, DOI 10.1016/j.drudis.2009.06.009 Dobkin C, 2000, NEUROSCIENCE, V100, P423, DOI 10.1016/S0306-4522(00)00292-X Dufner A, 1999, EXP CELL RES, V253, P100, DOI 10.1006/excr.1999.4683 Frankland PW, 2004, MOL PSYCHIATR, V9, P417, DOI 10.1038/sj.mp.4001432 Gantois I, 2006, NEUROBIOL DIS, V21, P346, DOI 10.1016/j.nbd.2005.07.017 Gross C, 2010, J NEUROSCI, V30, P10624, DOI 10.1523/JNEUROSCI.0402-10.2010 Guo WX, 2011, NAT MED, V17, P559, DOI 10.1038/nm.2336 Guo WX, 2012, HUM MOL GENET, V21, P681, DOI 10.1093/hmg/ddr501 Hagerman R., 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-12 Huber KM, 2002, P NATL ACAD SCI USA, V99, P7746, DOI 10.1073/pnas.122205699 Irwin SA, 2001, AM J MED GENET, V98, P161, DOI 10.1002/1096-8628(20010115)98:2<161::AID-AJMG1025>3.0.CO;2-B Irwin SA, 2002, AM J MED GENET, V111, P140, DOI 10.1002/ajmg.10500 Ivanco TL, 2002, HIPPOCAMPUS, V12, P47, DOI 10.1002/hipo.10004 Jacobs S, 2010, J NEUROSCI, V30, P4508, DOI 10.1523/JNEUROSCI.5027-09.2010 Koekkoek SKE, 2005, NEURON, V47, P339, DOI 10.1016/j.neuron.2005.07.005 Kooy RF, 1996, AM J MED GENET, V64, P241, DOI 10.1002/(SICI)1096-8628(19960809)64:2<241::AID-AJMG1>3.0.CO;2-X Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023 Kwon CH, 2006, GENESIS, V44, P130, DOI 10.1002/gene.20197 Levenga J, 2010, TRENDS MOL MED, V16, P516, DOI 10.1016/j.molmed.2010.08.005 Luikart BW, 2005, J NEUROSCI, V25, P3774, DOI 10.1523/JNEUROSCI.0041-05.2005 Luo Y., 2010, PLOS GENETICS, V6 McNaughton CH, 2008, BEHAV NEUROSCI, V122, P293, DOI [10.1037/0735-7044.122.2.293, 10.1037/0735-7044A22.2.293] Mientjes EJ, 2006, NEUROBIOL DIS, V21, P549, DOI 10.1016/j.nbd.2005.08.019 Mihalek RM, 1999, P NATL ACAD SCI USA, V96, P12905, DOI 10.1073/pnas.96.22.12905 Min WW, 2009, NEUROPHARMACOLOGY, V56, P463, DOI 10.1016/j.neuropharm.2008.09.017 Mines MA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009706 Mineur YS, 2006, BEHAV BRAIN RES, V168, P172, DOI 10.1016/j.bbr.2005.11.004 Mineur YS, 2002, HIPPOCAMPUS, V12, P39, DOI 10.1002/hipo.10005 Moon J, 2006, BEHAV NEUROSCI, V120, P1367, DOI 10.1037/0735-7044.120.6.1367 Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x Nimchinsky EA, 2001, J NEUROSCI, V21, P5139 Nosyreva ED, 2006, J NEUROPHYSIOL, V95, P3291, DOI 10.1152/jn.01316.2005 O'Donnell WT, 2002, ANNU REV NEUROSCI, V25, P315, DOI 10.1146/annurev.neuro.25.112701.142909 Osterweil EK, 2010, J NEUROSCI, V30, P15616, DOI 10.1523/JNEUROSCI.3888-10.2010 Pacey LKK, 2007, GLIA, V55, P1601, DOI 10.1002/glia.20573 Paradee W, 1999, NEUROSCIENCE, V94, P185, DOI 10.1016/S0306-4522(99)00285-7 Peier AM, 2000, HUM MOL GENET, V9, P1145, DOI 10.1093/hmg/9.8.1145 Restivo L, 2005, P NATL ACAD SCI USA, V102, P11557, DOI 10.1073/pnas.0504984102 Reyniers E, 1999, AM J MED GENET, V84, P245, DOI 10.1002/(SICI)1096-8628(19990528)84:3<245::AID-AJMG16>3.0.CO;2-U Ronesi JA, 2008, SCI SIGNAL, V1, DOI 10.1126/stke.15pe6 RUDELLI RD, 1985, ACTA NEUROPATHOL, V67, P289 SCHWEGLER H, 1995, BEHAV BRAIN RES, V67, P29, DOI 10.1016/0166-4328(95)91998-3 Selby L, 2007, NEUROSCI LETT, V412, P227, DOI 10.1016/j.neulet.2006.11.062 Sharma A, 2010, J NEUROSCI, V30, P694, DOI 10.1523/JNEUROSCI.3696-09.2010 Spencer CM, 2005, GENES BRAIN BEHAV, V4, P420, DOI 10.1111/j.1601-183X.00123.x Van Dam D, 2000, BEHAV BRAIN RES, V117, P127, DOI 10.1016/S0166-4328(00)00296-5 VERKERK AJMH, 1991, CELL, V65, P905, DOI 10.1016/0092-8674(91)90397-H Wang HP, 2004, HUM MOL GENET, V13, P79, DOI 10.1093/hmg/ddh009 Wang T, 2012, CURR OPIN GENET DEV, V22, P256, DOI 10.1016/j.gde.2012.02.002 Yuskaitis CJ, 2010, BBA-MOL BASIS DIS, V1802, P1006, DOI 10.1016/j.bbadis.2010.06.015 Yuskaitis CJ, 2010, BIOCHEM PHARMACOL, V79, P632, DOI 10.1016/j.bcp.2009.09.023 Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009 NR 66 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 60 EP 71 DI 10.1002/aur.1342 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300007 PM 24408886 ER PT J AU Yi, L Feng, C Quinn, PC Ding, HY Li, J Liu, YB Lee, K AF Yi, Li Feng, Cong Quinn, Paul C. Ding, Haiyan Li, Jiao Liu, Yubing Lee, Kang TI Do Individuals with and without Autism Spectrum Disorder Scan Faces Differently? A New Multi-Method Look at an Existing Controversy SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; face scanning; face recognition; eye tracking ID DIAGNOSTIC INTERVIEW; NEURAL CIRCUITRY; YOUNG-CHILDREN; RECOGNITION; FIXATION; GAZE; IMPAIRMENT; LOOKING; SKILLS; EYES AB Individuals with autism spectrum disorder (ASD) are known to process faces atypically. However, there has been considerable controversy regarding whether ASD individuals also scan faces differently from typical adults. Here we compared ASD individuals' face-scanning patterns with those of typically developing (TD) controls and intellectually disabled (ID) but non-ASD individuals with the use of an eye tracker and multiple approaches to analyze eye-tracking data. First, we analyzed the eye movement data with a traditional approach, measuring fixation duration on each area of interest within the face. We found that compared with TD and ID individuals, ASD individuals looked significantly shorter at the right eye. Second, we used a data-driven method that analyzes fixations on each pixel of the face stimulus and found that individuals with ASD looked more at the central nasal area than TD and ID individuals. Third, we used a novel saccade path analysis that measures frequencies of saccades between major face areas. We found that ASD individuals scanned less often between core facial features than TD individuals but did not differ from ID individuals. Findings from the multi-method approaches show that individuals with ASD appear not to have a pervasive ASD-specific atypicality in visual attention toward the face. The ASD-specific atypical face-scanning patterns were shown to be limited to fixations on the eyes and nose. Autism Res 2014, 7: 72-83. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Yi, Li; Li, Jiao; Liu, Yubing] Sun Yat Sen Univ, Dept Psychol, Guangzhou 510275, Guangdong, Peoples R China. [Feng, Cong] Sun Yat Sen Univ, Dept Philosophy, Guangzhou 510275, Guangdong, Peoples R China. [Feng, Cong] Sun Yat Sen Univ, Inst Log & Cognit, Guangzhou 510275, Guangdong, Peoples R China. [Quinn, Paul C.] Univ Delaware, Dept Psychol, Newark, DE USA. [Ding, Haiyan] Guangzhou Zhanneng Vocat Training Ctr Disabled, Guangzhou, Guangdong, Peoples R China. [Lee, Kang] Univ Toronto, Dr Eric Jackman Inst Child Study, Toronto, ON, Canada. RP Yi, L (reprint author), Sun Yat Sen Univ, Dept Psychol, 135 Xingang West Rd, Guangzhou 510275, Guangdong, Peoples R China. EM yili5@mail.sysu.edu.cn; kang.lee@utoronto.ca FU Humanity and Social Science Youth Foundation of the Ministry of Education of China [12YJC190034]; National Natural Science Foundation of China [31200779]; Fundamental Research Funds for the Central Universities [13wkpy40]; National Institutes of Health [R01HD48962, R01HD46526]; Natural Sciences and Engineering Research Council of Canad; Social Sciences and Humanities Research Council of Canada FX This work was supported by grants from the Humanity and Social Science Youth Foundation of the Ministry of Education of China (12YJC190034), the National Natural Science Foundation of China (31200779), the Fundamental Research Funds for the Central Universities (13wkpy40), and grants from National Institutes of Health (R01HD48962 and R01HD46526) and Natural Sciences and Engineering Research Council of Canada; Grant sponsor: the Social Sciences and Humanities Research Council of Canada. CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Blais C, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003022 BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x Boucher J, 1998, J CHILD PSYCHOL PSYC, V39, P171, DOI 10.1017/S0021963097001820 Caldara R, 2011, BEHAV RES METHODS, V43, P864, DOI 10.3758/s13428-011-0092-x Chauvin A, 2005, J VISION, V5, P659, DOI 10.1167/5.9.1 Chawarska K, 2009, J AUTISM DEV DISORD, V39, P1663, DOI 10.1007/s10803-009-0803-7 Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6 Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433 Falck-Ytter T, 2008, AUTISM RES, V1, P297, DOI 10.1002/aur.45 Falck-Ytter T, 2010, DEVELOPMENTAL SCI, V13, P864, DOI 10.1111/j.1467-7687.2009.00942.x Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016 Fu GY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037688 Gepner B, 1996, CHILD NEUROPSYCHOL, V2, P123, DOI 10.1080/09297049608401357 Gilliam E., 2006, GILLIAM AUTISM RATIN Grice SJ, 2001, NEUROREPORT, V12, P2697, DOI 10.1097/00001756-200108280-00021 Hall GBC, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010804 Hernandez N, 2009, NEUROPSYCHOLOGIA, V47, P1004, DOI 10.1016/j.neuropsychologia.2008.10.023 Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5 Jones W, 2008, ARCH GEN PSYCHIAT, V65, P946, DOI 10.1001/archpsyc.65.8.946 Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240 Klin A, 2008, DEVELOPMENTAL SCI, V11, P40, DOI 10.1111/j.1467-7687.2007.00608.x Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 McCarthy A, 2006, J CROSS CULT PSYCHOL, V37, P717, DOI 10.1177/0022022106292079 McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x Monk CS, 2010, J PSYCHIATR NEUROSCI, V35, P105, DOI 10.1503/jpn.090085 Morita T, 2011, SOCIAL NEUROSCIENCE, V7, P223, DOI 10.1080/17470919.2011.598945 Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369 Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059 Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7 Schultz RT, 2003, PHILOS T ROY SOC B, V358, P415, DOI 10.1098/rstb.2002.1208 South M., 2011, TXB AUTISM SPECTRUM, P409 Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925 Tanaka JW, 2010, J CHILD PSYCHOL PSYC, V51, P944, DOI 10.1111/j.1469-7610.2010.02258.x Trepagnier C, 2002, CYBERPSYCHOL BEHAV, V5, P213, DOI 10.1089/109493102760147204 van der Geest JN, 2002, J CHILD PSYCHOL PSYC, V43, P669, DOI 10.1111/1469-7610.00055 Webb SJ, 2006, J AUTISM DEV DISORD, V36, P881, DOI 10.1007/s10803-006-0126-x Weng SJ, 2011, J CHILD PSYCHOL PSYC, V52, P296, DOI 10.1111/j.1469-7610.2010.02317.x Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56 Yuki M, 2007, J EXP SOC PSYCHOL, V43, P303, DOI 10.1016/j.jesp.2006.02.004 NR 46 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 72 EP 83 DI 10.1002/aur.1340 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300008 PM 24124133 ER PT J AU Au-Yeung, SK Kaakinen, JK Benson, V AF Au-Yeung, Sheena K. Kaakinen, Johanna K. Benson, Valerie TI Cognitive Perspective-Taking During Scene Perception in Autism Spectrum Disorder: Evidence From Eye Movements SO AUTISM RESEARCH LA English DT Article DE autism; Asperger's syndrome; theory of mind; information processing; eye movements; scene perception ID ASPERGER-SYNDROME; REVISED VERSION; ATTENTION; MIND AB The present study examined how eye movements during scene viewing are modulated by adopting psychological perspectives in both adults with autism spectrum disorders (ASD) and typically developing adults. In the current study, participants viewed house scenes with either non-perspective-taking (look for valuable items/features of the house that need fixing) or perspective-taking instructions (imagine that you are a burglar/repairman) while their eye movements were recorded. The eye movement measures revealed that for the look for the valuable items and burglar perspective task, the ASD group showed typical relevance effects (the preference to look at schema-relevant compared with schema-irrelevant targets) in their eye movements. However, we found subtle processing differences between the groups that were related to initial orienting to and processing of schema-relevant items for the look for the features that need fixing and the repairman perspective-taking task. There was an absence of a relevance effect for the ASD group for the repairman perspective and its non-perspective-taking equivalent instruction showing that the identification of items relevant to those schemas was more difficult for the ASD group. The present findings suggest that resolving ambiguity may be a defining feature of complex information processing deficits in ASD. Autism Res 2014, 7: 84-93. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Au-Yeung, Sheena K.; Benson, Valerie] Univ Southampton, Sch Psychol, Southampton SO17 1BJ, Hants, England. [Kaakinen, Johanna K.] Univ Turku, Dept Psychol, Turku, Finland. RP Benson, V (reprint author), Univ Southampton, Sch Psychol, Shackleton Bldg, Southampton SO17 1BJ, Hants, England. EM V.Benson@soton.ac.uk FU Economic and Social Research Council (ESRC) [ES/1019723/1] FX This work was supported by the Economic and Social Research Council (ESRC Reference Number: ES/1019723/1). We would like to thank our participants, their carers, and the staff of the Southampton Adult Asperger's Society, the University of Southampton, the Hampshire Autistic Society, the Autism Diagnostic and Research Centre, the National Autistic Society, and the Children on the Autistic Spectrum Parents' Association for supporting our research. The authors declare no conflict of interest. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Au-Yeung S. K., 2011, AUTISM RES TREATMENT, V2012, P1, DOI 10.1155/2011/657383 Baron-Cohen S, 2005, J AUTISM DEV DISORD, V35, P807, DOI 10.1007/s10803-005-0026-5 Baron-Cohen S, 2009, ANN NY ACAD SCI, V1156, P68, DOI 10.1111/j.1749-6632.2009.04467.x Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643 Baron-Cohen S., 2001, PRISME, V34, P174 Benson V, 2012, Q J EXP PSYCHOL, V65, P1139, DOI 10.1080/17470218.2011.644305 Benson V, 2009, NEUROPSYCHOLOGIA, V47, P1178, DOI 10.1016/j.neuropsychologia.2008.11.019 Henderson JM, 2009, PSYCHON B REV, V16, P850, DOI 10.3758/PBR.16.5.850 Kaakinen JK, 2008, APPL COGNITIVE PSYCH, V22, P319, DOI 10.1002/acp.1412 Kaakinen JK, 2011, Q J EXP PSYCHOL, V64, P1372, DOI 10.1080/17470218.2010.548872 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C., 2001, AUTISM DIAGNOSTIC OB Loth E, 2011, J AUTISM DEV DISORD, V41, P945, DOI 10.1007/s10803-010-1124-6 Minshew N. J., 2008, SPEAKERS J, V8, P25 Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303 Minshew NJ, 2008, CURR CLIN NEUROL, P381, DOI 10.1007/978-1-60327-489-0_18 Minshew NJ, 1998, MENT RETARD DEV D R, V4, P129, DOI 10.1002/(SICI)1098-2779(1998)4:2<129::AID-MRDD10>3.0.CO;2-X PICHERT JW, 1977, J EDUC PSYCHOL, V69, P309, DOI 10.1037//0022-0663.69.4.309 Rayner K, 2009, Q J EXP PSYCHOL, V62, P1457, DOI 10.1080/17470210902816461 Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170 The Psychological Corporation, 1999, WECHSL ABBR SCAL INT World Health Organisation, 1992, INT STAT CLASS DIS R Yarbus A. L., 1967, EYE MOVEMENTS VISION NR 24 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 84 EP 93 DI 10.1002/aur.1352 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300009 PM 24265216 ER PT J AU Madsen, GF Bilenberg, N Cantio, C Oranje, B AF Madsen, Gitte Falcher Bilenberg, Niels Cantio, Cathriona Oranje, Bob TI Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; PPI; sensorimotor gating; sensitization; children; auditory processing ID SENSORIMOTOR GATING DEFICITS; PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; ACOUSTIC STARTLE; 1ST-EPISODE SCHIZOPHRENIA; NEUROMOTOR PRECURSORS; DIAGNOSTIC INTERVIEW; ANTIPSYCHOTIC-NAIVE; EMOTIONAL FACES; BIRTH COHORT AB The relation between autism spectrum disorders (ASD) and schizophrenia is a subject of intense debate and research due to evidence of common neurobiological pathways in the two disorders. The objective of this study was to explore whether deficits in prepulse inhibition (PPI) of the startle reflex, as usually seen in schizophrenic patients, can be replicated in a group of children with ASD in comparison with a group of matched neuro-typically developed (NTD) controls. An additional aim was to explore possible psychophysiological subgroups within our ASD sample. In a case-control design, 35 ASD patients and 40 matched NTD controls were tested in a psychophysiological test battery. The PPI of the acoustic startle reflex was analyzed in 18 ASD subjects and 34 NTD controls. Habituation and sensitization were analyzed in 23 ASD subjects and 39 NTD controls. In trials with less intense prestimuli (76dB), patients with ASD did not display the drop in percentage PPI normally found in healthy controls. In addition, ASD patients showed significantly increased sensitization compared with NTD controls. Combined, our results may reflect the hypersensitivity to sensory information in children with ASD. The relation to PPI deficits observed in schizophrenia is not apparent. Future research should study the developmental course of PPI deficits in ASD patients in a longitudinal design. AutismRes 2014, 7: 94-103. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Madsen, Gitte Falcher; Bilenberg, Niels; Cantio, Cathriona] Univ Southern Denmark, Dept Child & Adolescent Mental Hlth Odense, Fac Hlth Sci, Res Unit Univ Funct, Glostrup, Denmark. [Oranje, Bob] Univ Copenhagen, Copenhagen Univ Hosp, Dept Neurol Psychiat & Sensory Sci, Psychiat Ctr Glostrup,Fac Hlth Sci,CNSR, Glostrup, Denmark. [Oranje, Bob] Univ Copenhagen, Ctr Clin Intervent & Neuropsychiat Schizophrenia, Dept Neurol Psychiat & Sensory Sci,Fac Hlth Sci, Copenhagen Univ Hosp,Psychiat Ctr Glostrup, Glostrup, Denmark. RP Madsen, GF (reprint author), Child & Adolescent Psychiat Dept, Sdr Blvd 29, DK-5000 Odense C, Denmark. EM gitte.falcher.madsen1@rsyd.dk RI Bilenberg, Niels/I-6027-2014 FU Psychiatric Research Foundation in the Region of Southern Denmark [09-5810]; Gangsted Foundation [1415-8436]; Fru Hermansens Foundation [00962-0001] FX This study was supported by The Psychiatric Research Foundation in the Region of Southern Denmark grant 09-5810; Gangsted Foundation grant 1415-8436, and Fru Hermansens Foundation grant 00962-0001. CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE ADLER LE, 1982, BIOL PSYCHIAT, V17, P639 Adolphs R, 2010, ANN NY ACAD SCI, V1191, P42, DOI 10.1111/j.1749-6632.2010.05445.x Aggernaes B, 2010, INT J NEUROPSYCHOPH, V13, P1383, DOI 10.1017/S1461145710000787 Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444 Billstedt E, 2007, J CHILD PSYCHOL PSYC, V48, P1102, DOI 10.1111/j.1469-7610.2007.01774.x BRAFF D, 1978, PSYCHOPHYSIOLOGY, V15, P339, DOI 10.1111/j.1469-8986.1978.tb01390.x BRAFF DL, 1993, SCHIZOPHRENIA BULL, V19, P233 Braff DL, 2001, SCHIZOPHR RES, V49, P171, DOI 10.1016/S0920-9964(00)00139-0 Braff DL, 2001, PSYCHOPHARMACOLOGY, V156, P234, DOI 10.1007/s002130100810 BRAFF DL, 1990, ARCH GEN PSYCHIAT, V47, P181 Calkins ME, 2007, SCHIZOPHRENIA BULL, V33, P33, DOI 10.1093/schbul/sbl044 Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2 Craddock N, 2010, BRIT J PSYCHIAT, V196, P92, DOI 10.1192/bjp.bp.109.073429 Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239 Hammer TB, 2013, J PSYCHIATR NEUROSCI, V38, P34, DOI 10.1503/jpn.110129 Hare TA, 2008, BIOL PSYCHIAT, V63, P927, DOI 10.1016/j.biopsych.2008.03.015 ISON JR, 1983, PERCEPT PSYCHOPHYS, V34, P84, DOI 10.3758/BF03205900 Jensen KS, 2007, NEUROPSYCHOPHARMACOL, V32, P2117, DOI 10.1038/sj.npp.1301350 JONES P, 1994, LANCET, V344, P1398, DOI 10.1016/S0140-6736(94)90569-X Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532 King BH, 2011, BRAIN RES, V1380, P34, DOI 10.1016/j.brainres.2010.11.031 Kleinhans NM, 2009, AM J PSYCHIAT, V166, P467, DOI 10.1176/appi.ajp.2008.07101681 Kliemann D, 2010, J NEUROSCI, V30, P12281, DOI 10.1523/JNEUROSCI.0688-10.2010 KOLVIN I, 1971, BRIT J PSYCHIAT, V118, P381, DOI 10.1192/bjp.118.545.381 Kumari V, 2005, PSYCHOPHYSIOLOGY, V42, P588, DOI 10.1111/j.1469-8986.2005.00346.x Kumari V, 2003, PSYCHIAT RES-NEUROIM, V122, P99, DOI 10.1016/s0925-4927(02)00123-3 Kumari V, 2005, NEUROIMAGE, V26, P1052, DOI 10.1016/j.neuroimage.2005.03.002 Kumari V, 2008, CORTEX, V44, P1206, DOI 10.1016/j.cortex.2007.11.007 Leask SJ, 2002, BRIT J PSYCHIAT, V181, P387, DOI 10.1192/bjp.181.5.387 Light GA, 2000, BIOL PSYCHIAT, V47, P463, DOI 10.1016/S0006-3223(99)00280-2 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Ludewig K, 2003, BIOL PSYCHIAT, V54, P121, DOI 10.1016/S0006-3223(03)01925-X Mackeprang T, 2002, BIOL PSYCHIAT, V52, P863, DOI 10.1016/S0006-3223(02)01409-9 McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150 MCGHIE A, 1961, BRIT J MED PSYCHOL, V34, P103 Meincke U, 2004, PSYCHIAT RES, V126, P51, DOI 10.1016/j.psychres.2003.01.003 Milad MR, 2012, ANNU REV PSYCHOL, V63, P129, DOI 10.1146/annurev.psych.121208.131631 Monk CS, 2010, J PSYCHIATR NEUROSCI, V35, P105, DOI 10.1503/jpn.090085 Morgan VA, 2008, BRIT J PSYCHIAT, V193, P364, DOI 10.1192/bjp.bp.107.044461 Mouridsen SE, 2008, J PSYCHIATR PRACT, V14, P5, DOI 10.1097/01.pra.0000308490.47262.e0 ONeill M, 1997, J AUTISM DEV DISORD, V27, P283, DOI 10.1023/A:1025850431170 Oranje B, 2012, PSYCHIAT RES, V206, P287 Oranje B, 2013, SCHIZOPHRENIA BULL, V39, P684, DOI 10.1093/schbul/sbs071 ORNITZ EM, 1993, J AUTISM DEV DISORD, V23, P619, DOI 10.1007/BF01046105 Owen MJ, 2011, BRIT J PSYCHIAT, V198, P173, DOI 10.1192/bjp.bp.110.084384 Parwani A, 2000, BIOL PSYCHIAT, V47, P662, DOI 10.1016/S0006-3223(99)00148-1 Perry W, 2007, BIOL PSYCHIAT, V61, P482, DOI 10.1016/j.biopsych.2005.09.025 Quednow BB, 2008, BIOL PSYCHIAT, V64, P766, DOI 10.1016/j.biopsych.2008.04.019 Rapoport J, 2009, J AM ACAD CHILD PSY, V48, P10, DOI 10.1097/CHI.0b013e31818b1c63 Rapoport JL, 2012, MOL PSYCHIATR, V17, P1228, DOI 10.1038/mp.2012.23 RUTTER M, 1972, J AUTISM CHILD SCHIZ, V2, P315, DOI 10.1007/BF01537622 Schiffman J, 2004, AM J PSYCHIAT, V161, P2021, DOI 10.1176/appi.ajp.161.11.2021 Stahlberg O, 2004, J NEURAL TRANSM, V111, P891, DOI 10.1007/s00702-004-0115-1 Turetsky BI, 2007, SCHIZOPHRENIA BULL, V33, P69, DOI 10.1093/schbul/sbl060 Unenge Hallerback M, 2012, PSYCHIAT RES, V198, P12 Van O. J., 2009, LANCET, V374, P635 WALKER EF, 1993, AM J PSYCHIAT, V150, P1654 WALKER EF, 1994, SCHIZOPHRENIA BULL, V20, P441 Weng SJ, 2011, J CHILD PSYCHOL PSYC, V52, P296, DOI 10.1111/j.1469-7610.2010.02317.x Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023 Yuhas J, 2011, J AUTISM DEV DISORD, V41, P248, DOI 10.1007/s10803-010-1040-9 Ziermans TB, 2012, SCHIZOPHR RES, V134, P10, DOI 10.1016/j.schres.2011.10.009 NR 64 TC 3 Z9 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 94 EP 103 DI 10.1002/aur.1337 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300010 PM 24124111 ER PT J AU Laycock, R Cross, AJ Nogare, FD Crewther, SG AF Laycock, Robin Cross, Alana Jade Nogare, Felicity Dalle Crewther, Sheila Gillard TI Self-Rated Social Skills Predict Visual Perception: Impairments in Object Discrimination Requiring Transient Attention Associated with High Autistic Tendency SO AUTISM RESEARCH LA English DT Article DE autism; dorsal stream; ventral stream; object discrimination; attention ID SPECTRUM DISORDER; FUNCTIONING AUTISM; BIOLOGICAL MOTION; RECOGNITION; FACE; COHERENCE; ADOLESCENTS; ACTIVATION; MECHANISM; DYSLEXIA AB Autism is usually defined by impairments in the social domain but has also been linked to deficient dorsal visual stream processing. However, inconsistent findings make the nature of this relationship unclear and thus, we examined the role of stimulus-driven transient attention, presumably activated by the dorsal stream in autistic tendency. Contrast thresholds for object discrimination were compared between groups with high and low self-rated autistic tendency utilizing the socially based Autism Spectrum Quotient (AQ). Visual stimuli were presented with either abrupt or with ramped contrast onsets/offsets in order to manipulate the demands of transient attention. Larger impairments in performance of abrupt compared with ramped object presentation were established in the high AQ group. Furthermore, self-reported social skills predicted abrupt task performance, suggesting an important visual perception deficiency in autism-related traits. Autism spectrum disorder may be associated with reduced utilization of the dorsal stream to rapidly activate attention prior to ventral stream processing when stimuli are transient. Autism Res 2014, 7: 104-111. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Laycock, Robin; Cross, Alana Jade; Nogare, Felicity Dalle; Crewther, Sheila Gillard] La Trobe Univ, Sch Psychol Sci, Melbourne, Vic, Australia. RP Laycock, R (reprint author), La Trobe Univ, Sch Psychol Sci, Bundoora, Vic 3086, Australia. EM r.laycock@latrobe.edu.au FU Australian Research Council [DP0985837] FX We thank Ben Ong for assistance with data analysis. This work was supported by the Australian Research Council (Discovery Project, DP0985837). The authors have no conflicts of interest to declare. CR Almeida RA, 2010, NEUROPSYCHOLOGIA, V48, P4117, DOI 10.1016/j.neuropsychologia.2010.10.009 Amirault M, 2009, J AUTISM DEV DISORD, V39, P1522, DOI 10.1007/s10803-009-0821-5 Arsalidou M, 2011, BRAIN TOPOGR, V24, P149, DOI 10.1007/s10548-011-0171-4 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Bayliss AP, 2005, BRIT J PSYCHOL, V96, P95, DOI 10.1348/000712604X15626 Bertone A, 2003, J COGNITIVE NEUROSCI, V15, P218, DOI 10.1162/089892903321208150 Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434 Brieber S, 2010, NEUROPSYCHOLOGIA, V48, P1644, DOI 10.1016/j.neuropsychologia.2010.02.007 Bullier J, 2001, BRAIN RES REV, V36, P96, DOI 10.1016/S0165-0173(01)00085-6 Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018 Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6 Doniger GM, 2002, ARCH GEN PSYCHIAT, V59, P1011, DOI 10.1001/archpsyc.59.11.1011 Eliot L, 2011, NEURON, V72, P895, DOI 10.1016/j.neuron.2011.12.001 Greenaway R, 2005, PSYCHOL SCI, V16, P987, DOI 10.1111/j.1467-9280.2005.01648.x Grinter EJ, 2010, BRAIN RES BULL, V82, P147, DOI 10.1016/j.brainresbull.2010.02.016 Grinter EJ, 2009, J AUTISM DEV DISORD, V39, P1278, DOI 10.1007/s10803-009-0740-5 Herrington JD, 2007, RES AUTISM SPECT DIS, V1, P14, DOI 10.1016/j.rasd.2006.07.002 HICKS TP, 1983, J PHYSIOL-LONDON, V337, P183 Humphreys K, 2008, AUTISM RES, V1, P52, DOI 10.1002/aur.1 Jones CRG, 2011, AUTISM RES, V4, P347, DOI 10.1002/aur.209 Keehn B, 2008, J CHILD PSYCHOL PSYC, V49, P1296, DOI 10.1111/j.1469-7610.2008.01937.x Keehn B, 2010, J CHILD PSYCHOL PSYC, V51, P1251, DOI 10.1111/j.1469-7610.2010.02257.x Kveraga K, 2007, J NEUROSCI, V27, P13232, DOI 10.1523/JNEUROSCI.3481-07.2007 Laycock R, 2007, NEUROSCI BIOBEHAV R, V31, P363, DOI 10.1016/j.neubiorev.2006.10.003 Laycock R, 2011, BEHAV BRAIN FUNCT, V7, DOI 10.1186/1744-9081-7-34 McCleery JP, 2007, BIOL PSYCHIAT, V62, P1007, DOI 10.1016/j.biopsych.2007.02.009 Milne E, 2006, J AUTISM DEV DISORD, V36, P225, DOI 10.1007/s10803-005-0052-3 Nassi JJ, 2006, J NEUROSCI, V26, P12789, DOI 10.1523/JNEUROSCI.4044-06.2006 Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003 Pellicano E, 2008, NEUROPSYCHOLOGIA, V46, P2593, DOI 10.1016/j.neuropsychologia.2008.04.008 Pitcher D, 2009, CURR BIOL, V19, P319, DOI 10.1016/j.cub.2009.01.007 Rinehart N, 2010, AUTISM, V14, P47, DOI 10.1177/1362361309335718 Robertson CE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048173 Scherf KS, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00026 Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Spencer J, 2000, NEUROREPORT, V11, P2765, DOI 10.1097/00001756-200008210-00031 Sutherland A, 2010, BRAIN, V133, P2089, DOI 10.1093/brain/awq122 Thompson JC, 2007, NEUROIMAGE, V37, P966, DOI 10.1016/j.neuroimage.2007.05.058 Townsend J, 1996, J Int Neuropsychol Soc, V2, P541 Tsermentseli S, 2008, J AUTISM DEV DISORD, V38, P1201, DOI 10.1007/s10803-007-0500-3 Vlamings PHJM, 2010, BIOL PSYCHIAT, V68, P1107, DOI 10.1016/j.biopsych.2010.06.024 Vuilleumier P, 2003, NAT NEUROSCI, V6, P624, DOI 10.1038/nn1057 NR 42 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 104 EP 111 DI 10.1002/aur.1336 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300011 PM 24124093 ER PT J AU Cassidy, S Ropar, D Mitchell, P Chapman, P AF Cassidy, Sarah Ropar, Danielle Mitchell, Peter Chapman, Peter TI Can Adults With Autism Spectrum Disorders Infer What Happened to Someone From Their Emotional Response? SO AUTISM RESEARCH LA English DT Article DE autism; retrodictive mindreading; eye tracking; spontaneous emotion recognition; face processing ID HIGH-FUNCTIONING AUTISM; SPONTANEOUS FACIAL EXPRESSIONS; ASPERGER-SYNDROME; SOCIAL INFORMATION; MIND; CHILDREN; RECOGNITION; PERCEPTION; JUDGMENTS; ATTENTION AB Can adults with autism spectrum disorders (ASD) infer what happened to someone from their emotional response? Millikan has argued that in everyday life, others' emotions are most commonly used to work out the antecedents of behavior, an ability termed retrodictive mindreading. As those with ASD show difficulties interpreting others' emotions, we predicted that these individuals would have difficulty with retrodictive mindreading. Sixteen adults with high-functioning autism or Asperger's syndrome and 19 typically developing adults viewed 21 video clips of people reacting to one of three gifts (chocolate, monopoly money, or a homemade novelty) and then inferred what gift the recipient received and the emotion expressed by that person. Participants' eye movements were recorded while they viewed the videos. Results showed that participants with ASD were only less accurate when inferring who received a chocolate or homemade gift. This difficulty was not due to lack of understanding what emotions were appropriate in response to each gift, as both groups gave consistent gift and emotion inferences significantly above chance (genuine positive for chocolate and feigned positive for homemade). Those with ASD did not look significantly less to the eyes of faces in the videos, and looking to the eyes did not correlate with accuracy on the task. These results suggest that those with ASD are less accurate when retrodicting events involving recognition of genuine and feigned positive emotions, and challenge claims that lack of attention to the eyes causes emotion recognition difficulties in ASD. Autism Res 2014, 7: 112-123. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Cassidy, Sarah; Ropar, Danielle; Mitchell, Peter; Chapman, Peter] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England. RP Ropar, D (reprint author), Univ Nottingham, Sch Psychol, Univ Pk, Nottingham NG7 2RD, England. EM danielle.ropar@nottingham.ac.uk FU University of Nottingham, School of Psychology FX This research was carried out with the support of a PhD studentship awarded by the University of Nottingham, School of Psychology. CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289 American Psychiatric Association, 2000, DIAGN STAT MAN MENT American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Back E, 2007, CHILD DEV, V78, P397, DOI 10.1111/j.1467-8624.2007.01005.x Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 BARONCOHEN S, 1993, COGNITION EMOTION, V7, P507, DOI 10.1080/02699939308409202 Baron-Cohen S, 1999, J AUTISM DEV DISORD, V29, P407, DOI 10.1023/A:1023035012436 Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643 BARONCOHEN S, 1991, CHILD DEV, V62, P385, DOI 10.1111/j.1467-8624.1991.tb01539.x BaronCohen S, 1997, J CHILD PSYCHOL PSYC, V38, P813, DOI 10.1111/j.1469-7610.1997.tb01599.x BARTSCH K, 1989, CHILD DEV, V60, P946, DOI 10.1111/j.1467-8624.1989.tb03526.x Boraston ZL, 2008, J AUTISM DEV DISORD, V38, P574, DOI 10.1007/s10803-007-0421-1 Carroll JM, 1997, J PERS SOC PSYCHOL, V72, P164, DOI 10.1037/0022-3514.72.1.164 EKMAN P, 1990, J PERS SOC PSYCHOL, V58, P342, DOI 10.1037/0022-3514.58.2.342 EKMAN P, 1988, J PERS SOC PSYCHOL, V54, P414, DOI 10.1037//0022-3514.54.3.414 Fletcher-Watson S, 2008, J AUTISM DEV DISORD, V38, P1785, DOI 10.1007/s10803-008-0548-8 Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016 Freeth M, 2010, J AUTISM DEV DISORD, V40, P534, DOI 10.1007/s10803-009-0893-2 Freeth M, 2010, J EXP CHILD PSYCHOL, V105, P20, DOI 10.1016/j.jecp.2009.10.001 EKMAN P, 1982, J NONVERBAL BEHAV, V6, P238, DOI 10.1007/BF00987191 Gaigg Sebastian B, 2012, Front Integr Neurosci, V6, P113, DOI 10.3389/fnint.2012.00113 Gallese V, 1998, TRENDS COGN SCI, V2, P493, DOI 10.1016/S1364-6613(98)01262-5 Golan O, 2006, SOC NEUROSCI-UK, V1, P111, DOI 10.1080/17470910600980986 Goldman AI, 2005, COGNITION, V94, P193, DOI 10.1016/j.cognition.2004.01.005 Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6 Heaton P, 2012, PSYCHOL MED, V42, P2453, DOI 10.1017/S0033291712000621 Hernandez N, 2009, NEUROPSYCHOLOGIA, V47, P1004, DOI 10.1016/j.neuropsychologia.2008.10.023 Hess U, 2001, INT J PSYCHOPHYSIOL, V40, P129, DOI 10.1016/S0167-8760(00)00161-6 Humphreys K., 2007, NEUROPSYCHOLOGIA, V45, P658 Kanner L, 1943, NERV CHILD, V2, P217 Kasari C, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P309 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 Loveland KA, 2008, PERCEPT MOTOR SKILL, V107, P557, DOI 10.2466/PMS.107.2.557-575 Loveland KA, 2001, J AUTISM DEV DISORD, V31, P367, DOI 10.1023/A:1010608518060 Matsumoto A., 2006, J PERS SOC PSYCHOL, V91, P568 Matsumoto A., 2009, J NONVERBAL BEHAV, V33, P213 Millikan R. G., 2005, PERSPECTIVES IMITATI Naab PJ, 2007, EMOTION, V7, P736, DOI 10.1037/1528-3542.7A.736 Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030 O'Sullivan M., 1982, EMOTION HUMAN FACE, P281 Ogai Masahiro, 2003, Neuroreport, V14, P559, DOI 10.1097/00001756-200303240-00006 Perner J., 2010, COGNITION NEUROPSYCH, V1, P451 Philip RCM, 2010, PSYCHOL MED, V40, P1919, DOI 10.1017/S0033291709992364 Pillai D., 2012, PLOS ONE, V7 Povinelli DJ, 2003, TRENDS COGN SCI, V7, P157, DOI 10.1016/S1364-6613(03)00053-6 ROBINSON EJ, 1995, CHILD DEV, V66, P1022, DOI 10.1111/j.1467-8624.1995.tb00920.x Roeyers H, 2001, J CHILD PSYCHOL PSYC, V42, P271, DOI 10.1111/1469-7610.00718 Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7 Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925 Spezio ML, 2007, NEUROPSYCHOLOGIA, V45, P144, DOI 10.1016/j.neuropsychologia.2006.04.027 Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9 Uljarevic M, 2013, J AUTISM DEV DISORD, V43, P1517, DOI 10.1007/s10803-012-1695-5 Van Heuven W., 2010, EYE TRACKER OUTPUT U WAGNER HL, 1990, MOTIV EMOTION, V14, P27, DOI 10.1007/BF00995547 WAGNER HL, 1986, J PERS SOC PSYCHOL, V50, P737, DOI 10.1037/0022-3514.50.4.737 WAGNER HL, 1992, MOTIV EMOTION, V16, P347, DOI 10.1007/BF00992971 Wechsler D, 1999, WASI MANUAL WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288 NR 59 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 112 EP 123 DI 10.1002/aur.1351 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300012 PM 24307231 ER PT J AU Steadman, PE Ellegood, J Szulc, KU Turnbull, DH Joyner, AL Henkelman, RM Lerch, JP AF Steadman, Patrick E. Ellegood, Jacob Szulc, Kamila U. Turnbull, Daniel H. Joyner, Alexandra L. Henkelman, R. Mark Lerch, Jason P. TI Genetic Effects on Cerebellar Structure Across Mouse Models of Autism Using a Magnetic Resonance Imaging Atlas SO AUTISM RESEARCH LA English DT Article DE animal models; neuroimaging; neuroanatomy; structural MRI; genetics ID FALSE DISCOVERY RATE; PURKINJE-CELLS; RETT-SYNDROME; BRAIN-STEM; MICE; BEHAVIOR; MRI; SEROTONIN; ABNORMALITIES; ITGB3 AB Magnetic resonance imaging (MRI) of autism populations is confounded by the inherent heterogeneity in the individuals' genetics and environment, two factors difficult to control for. Imaging genetic animal models that recapitulate a mutation associated with autism quantify the impact of genetics on brain morphology and mitigate the confounding factors in human studies. Here, we used MRI to image three genetic mouse models with single mutations implicated in autism: Neuroligin-3 R451C knock-in, Methyl-CpG binding protein-2 (MECP2) 308-truncation and integrin 3 homozygous knockout. This study identified the morphological differences specific to the cerebellum, a structure repeatedly linked to autism in human neuroimaging and postmortem studies. To accomplish a comparative analysis, a segmented cerebellum template was created and used to segment each study image. This template delineated 39 different cerebellar structures. For Neuroligin-3 R451C male mutants, the gray (effect size (ES)=1.94, FDRq=0.03) and white (ES=1.84, q=0.037) matter of crus II lobule and the gray matter of the paraflocculus (ES=1.45, q=0.045) were larger in volume. The MECP2 mutant mice had cerebellar volume changes that increased in scope depending on the genotype: hemizygous males to homozygous females. The integrin 3 mutant mouse had a drastically smaller cerebellum than controls with 28 out of 39 cerebellar structures smaller. These imaging results are discussed in relation to repetitive behaviors, sociability, and learning in the context of autism. This work further illuminates the cerebellum's role in autism. Autism Res 2014, 7: 124-137. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Steadman, Patrick E.; Ellegood, Jacob; Henkelman, R. Mark; Lerch, Jason P.] Hosp Sick Children, Mouse Imaging Ctr, Toronto, ON M5T 3H7, Canada. [Steadman, Patrick E.; Henkelman, R. Mark; Lerch, Jason P.] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada. [Szulc, Kamila U.; Turnbull, Daniel H.] Skirball Inst Biomol Med, New York, NY USA. [Szulc, Kamila U.; Turnbull, Daniel H.] NYU, Dept Radiol, Sch Med, New York, NY 10016 USA. [Joyner, Alexandra L.] Mem Sloan Kettering Canc Ctr, Dept Dev Biol, New York, NY 10021 USA. RP Steadman, PE (reprint author), Hosp Sick Children, Mouse Imaging Ctr, 25 Orde St, Toronto, ON M5T 3H7, Canada. EM patrick.steadman@mail.utoronto.ca RI Henkelman, Mark/F-3662-2011 FU CIHR [MOP-106418]; OBI [IDS-11-02] FX Grant sponsor CIHR; Grant number: MOP-106418, Grant sponsor OBI; Grant number: IDS-11-02. CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47 Allen G, 2003, AM J PSYCHIAT, V160, P262, DOI 10.1176/appi.ajp.160.2.262 Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005 Anagnostou E., 2011, MOL AUTISM, V2, P2 Avants BB, 2008, MED IMAGE ANAL, V12, P26, DOI 10.1016/j.media.2007.06.004 Avants BB, 2011, NEUROIMAGE, V54, P2033, DOI 10.1016/j.neuroimage.2010.09.025 BAILEY A, 1995, PSYCHOL MED, V25, P63 Banerjee-Basu S, 2010, DIS MODEL MECH, V3, P133, DOI 10.1242/dmm.005439 BAUMAN M, 1985, NEUROLOGY, V35, P866 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289 Berry-Kravis EM, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004214 Bock NA, 2003, MAGNET RESON MED, V49, P158, DOI 10.1002/mrm.10326 Cahill LS, 2012, NEUROIMAGE, V60, P933, DOI 10.1016/j.neuroimage.2012.01.100 Carter MD, 2011, AUTISM RES, V4, P57, DOI 10.1002/aur.180 Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22 Chakravarty MM, 2013, HUM BRAIN MAPP, V34, P2635, DOI 10.1002/hbm.22092 Chugani DC, 2004, MENT RETARD DEV D R, V10, P112, DOI 10.1002/mrdd.20021 COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102 COURCHESNE E, 1995, J AUTISM DEV DISORD, V25, P19, DOI 10.1007/BF02178164 Coutinho AM, 2007, HUM GENET, V121, P243, DOI 10.1007/s00439-006-0301-3 D'Angelo E, 2013, FRONT NEURAL CIRCUIT, V6, DOI 10.3389/fncir.2012.00116 Dorr AE, 2008, NEUROIMAGE, V42, P60, DOI 10.1016/j.neuroimage.2008.03.037 Ellegood J, 2011, AUTISM RES, V4, P368, DOI 10.1002/aur.215 Ellegood J., 2012, FRONTIERS PSYCHIAT, V3, P1, DOI 10.3389/fpsyt.2012.00037 Etherton M, 2011, P NATL ACAD SCI USA, V108, P13764, DOI 10.1073/pnas.1111093108 Ey E, 2011, AUTISM RES, V4, P5, DOI 10.1002/aur.175 Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9 Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P171, DOI 10.1023/A:1019861721160 Franklin K.B.J., 2007, MOUSE BRAIN STEREOTA, V3rd Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037 Habas C, 2009, J NEUROSCI, V29, P8586, DOI 10.1523/JNEUROSCI.1868-09.2009 Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76 Hashimoto M, 2003, J NEUROSCI, V23, P11342 HASHIMOTO T, 1995, J AUTISM DEV DISORD, V25, P1, DOI 10.1007/BF02178163 Henderson C, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004218 Hof PR, 2000, COMP CYTOARCHITECTON Horev G, 2011, P NATL ACAD SCI USA, V108, P17076, DOI 10.1073/pnas.1114042108 Koekkoek SKE, 2005, NEURON, V47, P339, DOI 10.1016/j.neuron.2005.07.005 LARSELL O, 1952, J COMP NEUROL, V97, P281, DOI 10.1002/cne.900970204 Lerch JP, 2011, NEUROIMAGE, V54, P2086, DOI 10.1016/j.neuroimage.2010.09.086 Lerch JR, 2011, METHODS MOL BIOL, V711, P349, DOI 10.1007/978-1-61737-992-5_17 Manto M, 2012, CEREBELLUM, V11, P457, DOI 10.1007/s12311-011-0331-9 Martin LA, 2010, EUR J NEUROSCI, V31, P544, DOI 10.1111/j.1460-9568.2009.07073.x Moretti P, 2005, HUM MOL GENET, V14, P205, DOI 10.1093/hmg/ddi016 Nieman BJ, 2007, HUM BRAIN MAPP, V28, P567, DOI 10.1002/hbm.20408 Nieman BJ, 2005, MAGNET RESON MED, V54, P532, DOI 10.1002/mrm.20590 Pearson BL, 2012, BEHAV GENET, V42, P299, DOI 10.1007/s10519-011-9501-2 Pierce K, 2001, BIOL PSYCHIAT, V49, P655, DOI 10.1016/S0006-3223(00)01008-8 Piven J, 1997, NEUROLOGY, V49, P546 Pobbe RLH, 2012, PHYSIOL BEHAV, V107, P641, DOI 10.1016/j.physbeh.2012.02.024 RITVO ER, 1986, AM J PSYCHIAT, V143, P862 Robertson HR, 2011, J CHILD PSYCHOL PSYC, V52, P442, DOI 10.1111/j.1469-7610.2011.02380.x Samaco R. C., 2012, HUM MOL GENET, V22, P96, DOI [10.1093/hmg/dds406, DOI 10.1093/HMG/DDS406] SEARS LL, 1994, J AUTISM DEV DISORD, V24, P737, DOI 10.1007/BF02172283 Shahbazian MD, 2002, NEURON, V35, P243, DOI 10.1016/S0896-6273(02)00768-7 Sillitoe RV, 2012, MOUSE NERVOUS SYSTEM, P360, DOI 10.1016/B978-0-12-369497-3.10011-1 Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851 Sodhi MSK, 2004, INT REV NEUROBIOL, V59, P111 Spring S, 2007, NEUROIMAGE, V35, P1424, DOI 10.1016/j.neuroimage.2007.02.023 Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006 Stoodley CJ, 2009, NEUROIMAGE, V44, P489, DOI 10.1016/j.neuroimage.2008.08.039 Sudarov A, 2007, NEURAL DEV, V2, DOI 10.1186/1749-8104-2-26 Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221 Tsai PT, 2012, NATURE, V488, P647, DOI 10.1038/nature11310 Ullmann JFP, 2012, NEUROIMAGE, V62, P1408, DOI 10.1016/j.neuroimage.2012.05.061 Voogd J, 2012, CEREBELLUM, V11, P422, DOI 10.1007/s12311-012-0367-5 Voogd J, 1996, ANN NY ACAD SCI, V781, P553, DOI 10.1111/j.1749-6632.1996.tb15728.x Weiss LA, 2006, HUM GENET, V120, P93, DOI 10.1007/s00439-006-0196-z Weiss LA, 2006, EUR J HUM GENET, V14, P923, DOI 10.1038/sj.ejhg.5201644 Woodruff-Pak DS, 2010, P NATL ACAD SCI USA, V107, P1624, DOI 10.1073/pnas.0914207107 NR 71 TC 4 Z9 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 124 EP 137 DI 10.1002/aur.1344 PG 14 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300013 PM 24151012 ER PT J AU Kovac, J Luksic, MM Podkrajsek, KT Klancar, G Battelino, T AF Kovac, Jernej Luksic, Marta Macedoni Podkrajsek, Katarina Trebusak Klancar, Gasper Battelino, Tadej TI Rare Single Nucleotide Polymorphisms in the Regulatory Regions of the Superoxide Dismutase Genes in Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; superoxide dismutase; genetic variants; oxidative stress; ROS ID DE-NOVO MUTATIONS; INCREASED OXIDATIVE STRESS; METHYLATION; GENETICS; DISEASE; ASSOCIATION; ANTIOXIDANT; GLUTATHIONE; BIOMARKERS; CHILDREN AB Oxidative stress is suspected to be one of the several contributing factors in the etiology of autism spectrum disorder (ASD). We analyzed genes of the superoxide dismutase family (SOD1, SOD2, and SOD3) that are part of a major antioxidative stress system in human in order to detect the genetic variants contributing to the development of ASD. Using the optimized high-resolution melting (HRM) analysis, we identified two rare single nucleotide polymorphisms (SNPs) associated with the etiology of ASD. Both are located in the superoxide dismutase 1 (SOD1) gene and have a minor allele frequency in healthy population approximate to 5%. The SNP c.239+34A>C (rs2234694) and SNP g.3341C>G (rs36233090) were detected with an odds ratio of 2.65 and P<0.01. Both are located in the noncoding potentially regulatory regions of the SOD1 gene. This adds to the importance of rare SNPs in the etiology of complex diseases as well as to the importance of noncoding genetic variants analysis with a potential influence on the regulation of gene expression. Autism Res 2014, 7: 138-144. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Kovac, Jernej; Klancar, Gasper; Battelino, Tadej] Univ Childrens Hosp, UMC Ljubljana, Dept Endocrinol Diabet & Metab Dis, SI-1000 Ljubljana, Slovenia. [Luksic, Marta Macedoni] Univ Childrens Hosp, UMC Ljubljana, Dept Child Adolescent & Dev Neurol, Ctr Autism, SI-1000 Ljubljana, Slovenia. [Podkrajsek, Katarina Trebusak] Univ Childrens Hosp, UMC Ljubljana, Ctr Med Genet, SI-1000 Ljubljana, Slovenia. RP Battelino, T (reprint author), Univ Childrens Hosp, UMC Ljubljana, Dept Endocrinol Diabet & Metab Dis, Bohoriceva Ulica 20, SI-1000 Ljubljana, Slovenia. EM tadej.battelino@mf.uni-lj.si FU Slovenian National Research Agency [J3-2412, P3-0343] FX This study was supported by the Slovenian National Research Agency grants J3-2412 and P3-0343. No potential conflicts of interest relevant to this article were reported. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Anney R, 2012, HUM MOL GENET, V21, P4781, DOI 10.1093/hmg/dds301 Anney RJL, 2011, EUR J HUM GENET, V19, P1082, DOI 10.1038/ejhg.2011.75 Dunham I, 2012, NATURE, V489, P57, DOI 10.1038/nature11247 Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003 Celotto AM, 2012, BRAIN BEHAV, V2, P424, DOI 10.1002/brb3.73 Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007 Cooke MS, 2003, FASEB J, V17, P1195, DOI 10.1096/fj.02-0752rev Deuel RK, 2002, PEDIATR NEUROL, V26, P349, DOI 10.1016/S0887-8994(02)00390-9 Drummond GR, 2011, NAT REV DRUG DISCOV, V10, P453, DOI 10.1038/nrd3403 Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149 Flicek P, 2012, NUCLEIC ACIDS RES, V40, pD84, DOI 10.1093/nar/gkr991 Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559 Frustaci A, 2012, FREE RADICAL BIO MED, V52, P2128, DOI 10.1016/j.freeradbiomed.2012.03.011 Ghanizadeh A, 2012, NEUROCHEM RES, V37, P899, DOI 10.1007/s11064-011-0667-z Gorlov IP, 2008, AM J HUM GENET, V82, P100, DOI 10.1016/j.ajhg.2007.09.006 Halliwell B, 2006, J NEUROCHEM, V97, P1634, DOI 10.1111/j.1471-4159.2006.03907.x Hayashi M, 2001, J NEUROPATH EXP NEUR, V60, P350 Hayashi M, 2012, ADV EXP MED BIOL, V724, P278, DOI 10.1007/978-1-4614-0653-2_21 Holsinger KE, 2009, NAT REV GENET, V10, P639, DOI 10.1038/nrg2611 Hovnik T, 2009, DIABETES CARE, V32, P2258, DOI 10.2337/dc09-0852 James SJ, 2004, AM J CLIN NUTR, V80, P1611 Kennedy K. A. M., 2011, CELL MOL LIFE SCI, V69, P215 Larkin MA, 2007, BIOINFORMATICS, V23, P2947, DOI 10.1093/bioinformatics/btm404 Lee JS, 2007, MUTAT RES-FUND MOL M, V618, P130, DOI 10.1016/j.mrfmmm.2006.08.014 Main PAE, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-35 Mierswa I., 2006, 12 ACM SIGKDD INT C, P935 Migdal C, 2011, M S-MED SCI, V27, P405, DOI 10.1051/medsci/2011274017 Montuschi P, 2004, FASEB J, V18, P1791, DOI 10.1096/fj.04-2330rev Moore JH, 2006, J THEOR BIOL, V241, P252, DOI 10.1016/j.jtbi.2005.11.036 Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472 O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989 O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835 Reja V, 2010, METHODS, V50, pS10, DOI 10.1016/j.ymeth.2010.02.006 Robertson G, 2006, NUCLEIC ACIDS RES, V34, pD68, DOI 10.1093/nar/gkj075 Rozen S, 2000, Methods Mol Biol, V132, P365 Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945 Torsdottir G, 2005, BASIC CLIN PHARMACOL, V96, P146, DOI 10.1111/j.1742-7843.2005.pto960210.x Vaya J, 2013, BIOCHIMIE, V95, P578, DOI 10.1016/j.biochi.2012.03.005 Vesela A, 2002, PHYSIOL RES, V51, P335 Wagner EJ, 2012, NAT REV MOL CELL BIO, V13, P115, DOI 10.1038/nrm3274 Weiskopf D, 2010, J LEUKOCYTE BIOL, V87, P165, DOI 10.1189/jlb.0209065 Yorbik O, 2002, PROSTAG LEUKOTR ESS, V67, P341, DOI 10.1054/plef.439 Yu B, 2011, METHODS MOL BIOL, V760, P91, DOI 10.1007/978-1-61779-176-5_6 Zoroglu SS, 2004, EUR ARCH PSY CLIN N, V254, P143, DOI 10.1007/s00406-004-0456-7 NR 45 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 138 EP 144 DI 10.1002/aur.1345 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300014 PM 24155217 ER PT J AU Yoo, HJ Bahn, G Cho, IH Kim, EK Kim, JH Min, JW Lee, WH Seo, JS Jun, SS Bong, G Cho, S Shin, MS Kim, BN Kim, JW Park, S Laugeson, EA AF Yoo, Hee-Jeong Bahn, Geonho Cho, In-Hee Kim, Eun-Kyung Kim, Joo-Hyun Min, Jung-Won Lee, Won-Hye Seo, Jun-Seong Jun, Sang-Shin Bong, Guiyoung Cho, Soochurl Shin, Min-Sup Kim, Bung-Nyun Kim, Jae-Won Park, Subin Laugeson, Elizabeth A. TI A Randomized Controlled Trial of the Korean Version of the PEERS (R) Parent-Assisted Social Skills Training Program for Teens With ASD SO AUTISM RESEARCH LA English DT Article DE social skills intervention; intervention; clinical psychiatry; adolescents; pediatrics ID AUTISM SPECTRUM DISORDERS; COGNITIVE-BEHAVIORAL THERAPY; HEALTH-CARE; CHILDREN; ANXIETY; ADOLESCENTS; DEPRESSION; MOTHERS; INTERVENTION; INVENTORY AB Impaired social functioning is a hallmark feature of autism spectrum disorder (ASD), often requiring treatment throughout the life span. PEERS (R) (Program for the Education and Enrichment of Relational Skills) is a parent-assisted social skills training for teens with ASD. Although PEERS (R) has an established evidence base in improving the social skills of adolescents and young adults with ASD in North America, the efficacy of this treatment has yet to be established in cross-cultural validation trials. The objective of this study is to examine the feasibility and treatment efficacy of a Korean version of PEERS (R) for enhancing social skills through a randomized controlled trial (RCT).The English version of the PEERS (R) Treatment Manual (Laugeson & Frankel, 2010) was translated into Korean and reviewed by 21 child mental health professionals. Items identified as culturally sensitive were surveyed by 447 middle school students, and material was modified accordingly. Participants included 47 teens between 12 and 18 years of age with a diagnosis of ASD and a verbal intelligence quotient (IQ)65. Eligible teens were randomly assigned to a treatment group (TG) or delayed treatment control group (CG). Primary outcome measures included questionnaires and direct observations quantifying social ability and problems directly related to ASD. Secondary outcome measures included scales for depressive symptoms, anxiety, and other behavioral problems. Rating scales for parental depressive symptoms and anxiety were examined to detect changes in parental psychosocial functioning throughout the PEERS (R) treatment. Independent samples t-tests revealed no significant differences at baseline across the TG and CG conditions with regard to age (14.04 +/- 1.64 and 13.54 +/- 1.50 years), IQ (99.39 +/- 18.09 & 100.67 +/- 16.97), parental education, socioeconomic status, or ASD symptoms (p<0.05), respectively. Results for treatment outcome suggest that the TG showed significant improvement in communication and social interaction domain scores on the Autism Diagnostic Observation Schedule, interpersonal relationship and play/leisure time on the subdomain scores of the Korean version of the Vineland Adaptive Behavior Scale (p's<0.01), social skills knowledge total scores on the Test of Adolescent Social Skills KnowledgeRevised (p<0.01), and decreased depressive symptoms on the Child Depression Inventory following treatment (p<0.05). Analyses of parental outcome reveal a significant decrease in maternal state anxiety in the TG after controlling for potential confounding variables (p<0.05). Despite cultural and linguistic differences, the PEERS (R) social skills intervention appears to be efficacious for teens with ASD in Korea with modest cultural adjustment. In an RCT, participants receiving the PEERS (R) treatment showed significant improvement in social skills knowledge, interpersonal skills, and play/leisure skills, as well as a decrease in depressive symptoms and ASD symptoms. This study represents one of only a few cross-cultural validation trials of an established evidence-based treatment for adolescents with ASD. Autism Res2014, 7: 145-161. (c) 2014 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Yoo, Hee-Jeong; Bong, Guiyoung] Seoul Natl Univ, Dept Psychiat, Bundang Hosp, Songnam, South Korea. [Yoo, Hee-Jeong; Kim, Joo-Hyun; Cho, Soochurl; Shin, Min-Sup; Kim, Bung-Nyun; Kim, Jae-Won] Seoul Natl Univ, Coll Med, Seoul, South Korea. [Yoo, Hee-Jeong; Bong, Guiyoung] Seongnam Child & Adolescent Community Mental Hlth, Songnam, South Korea. [Bahn, Geonho] Kyung Hee Univ, Med Ctr, Dept Psychiat, Seoul, South Korea. [Bahn, Geonho] Kyung Hee Univ, Sch Med, Dept Psychiat, Seoul, South Korea. [Cho, In-Hee] Samsung Child Dev Res Ctr, Songnam, South Korea. [Kim, Eun-Kyung; Jun, Sang-Shin] Dankook Univ, Dept Special Educ, Yongin, South Korea. [Min, Jung-Won] Younghwa Hosp, Dept Psychiat, Inchon, South Korea. [Lee, Won-Hye] Seoul Natl Univ Hosp, Dept Clin Psychol, Seoul 110744, South Korea. [Seo, Jun-Seong] Gacheon Univ, Dept Psychiat, Gil Hosp, Inchon, South Korea. [Cho, Soochurl; Shin, Min-Sup; Kim, Bung-Nyun; Kim, Jae-Won; Park, Subin] Seoul Natl Univ Hosp, Dept Child & Adolescent Psychiat, Seoul 110744, South Korea. [Laugeson, Elizabeth A.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA. RP Laugeson, EA (reprint author), Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, 760 Westwood Plaza,Ste 48-243B, Los Angeles, CA 90024 USA. EM elaugeson@mednet.ucla.edu FU Seoul National University Bundang Hospital [02-2011-047]; Korea Healthcare Technology R&D Project from the Ministry of Health and Welfare, Republic of Korea [A120029] FX We are grateful to the teens and families who participated in this study. The authors thank the Medical Research Collaborating Center at Seoul National University Bundang Hospital for statistical analyses. This work was supported by a research grant (number 02-2011-047) from Seoul National University Bundang Hospital and Korea Healthcare Technology R&D Project (A120029) from the Ministry of Health and Welfare, Republic of Korea. Dr. Elizabeth Laugeson receives royalties from Routledge for sales of the PEERS (R) Treatment Manual. Dr. Hee Jeong Yoo receives royalties from Hakjisa for sales of the Korean versions of Autism Diagnostic Observation Scale and Social Communication Questionnaire. CR Abbeduto L, 2004, AM J MENT RETARD, V109, P237, DOI 10.1352/0895-8017(2004)109<237:PWACIM>2.0.CO;2 Achenbach TM, 1991, MANUAL CHILD BEHAV C American Psychiatric Association, 2000, DIAGN STAT MAN MENT American Psychiatric Association, 2013, DIAGN STAT MAN MENT Barker ET, 2011, DEV PSYCHOL, V47, P551, DOI 10.1037/a0021268 BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561 Cho SC, 1989, SEOUL J PSYCHIAT, V15, P150 Cho SC, 1990, J KOREAN NEUROPSYCHI, V29, P943 Constantino J., 2005, SOCIAL RESPONSIVE SC Daley Tamara C, 2002, TRANSCULT PSYCHIATRY, V39, P531, DOI [10.1177/136346150203900409, DOI 10.1177/136346150203900409] Do YK, 2013, SLEEP MED, V14, P195, DOI 10.1016/j.sleep.2012.09.004 Ekas NV, 2010, J AUTISM DEV DISORD, V40, P1274, DOI 10.1007/s10803-010-0986-y Nicpon MF, 2010, J AUTISM DEV DISORD, V40, P1028, DOI 10.1007/s10803-010-0952-8 Gantman A, 2012, J AUTISM DEV DISORD, V42, P1094, DOI 10.1007/s10803-011-1350-6 Graham F. M., 1990, MANUAL SOCIAL SKILLS Han H. M., 1986, KOREAN J NEUROPSYCHI, V25, P487 Han S., 2010, J ADV ACAD, V21, P628 Hoagwood K, 1996, J AM ACAD CHILD PSY, V35, P1055, DOI 10.1097/00004583-199608000-00017 Humphrey N, 2011, AUTISM, V15, P397, DOI 10.1177/1362361310387804 Karst JS, 2012, CLIN CHILD FAM PSYCH, V15, P247, DOI 10.1007/s10567-012-0119-6 Kim J. H., 2005, J KOREAN CHILD ADOLE, V16, P98 Kim T. L., 1993, EWHA VINELAND ADAPTI Kim T. L., 1992, CLIN RES SPECIAL CHI, V3, P133 KOVACS M, 1985, PSYCHOPHARMACOL BULL, V21, P995 Laugeson EA, 2011, SOCIAL SKILLS FOR TEENAGERS WITH DEVELOPMENTAL AND AUTISM SPECTRUM DISORDERS, P1 Laugeson EA, 2009, J AUTISM DEV DISORD, V39, P596, DOI 10.1007/s10803-008-0664-5 Laugeson EA, 2012, J AUTISM DEV DISORD, V42, P1025, DOI 10.1007/s10803-011-1339-1 Lee C. H., 1996, KOREAN J HLTH PSYCHO, V1, P1 Lee M, 2003, NEW DIR CHILD ADOLES, V99, P9, DOI 10.1002/cd.63 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C., 2008, AUTISM DIAGNOSTIC OB Maglione Margaret A, 2012, Pediatrics, V130 Suppl 2, pS169, DOI 10.1542/peds.2012-0900O Mandelberg J, 2014, J MENT HEALTH RES IN, V7, P45, DOI 10.1080/19315864.2012.730600 Moon Sung-Won, 2003, [Korean Journal Of Counseling And Psychotherapy, 한국심리학회지: 상담 및 심리치료], V15, P235 Myles B. S., 2001, ASPERGER SYNDROME DI Newman MG, 2010, INT J COGN THER, V3, P245 Oh KJ, 1997, K CBCL Park K., 1991, MANUAL KOREAN ED DEV Peacock G, 2012, J DEV BEHAV PEDIATR, V33, P2, DOI 10.1097/DBP.0b013e31823969de Ravindran N, 2012, J CHILD FAM STUD, V21, P311, DOI 10.1007/s10826-011-9477-9 Reaven J., 2012, AUTISM RES TREATMENT, DOI 10. 1155/2012/423905 Reichow B, 2012, COCHRANE DATABASE SY Renno P, 2013, J AUTISM DEV DISORD, V43, P2135, DOI 10.1007/s10803-013-1767-1 Ruiz-Robledillo N, 2013, PSYCHOL HEALTH, V28, P1246, DOI 10.1080/08870446.2013.800517 Rutter M., 2003, SOCIAL COMMUNICATION Schohl K. A., 2013, J AUTISM DEV DISORDE, DOI 10.1007/s10803-013-1900-1 Shattuck PT, 2011, PLOS ONE, V6 Shivers CM, 2013, J AUTISM DEV DISORD, V43, P1336, DOI 10.1007/s10803-012-1685-7 SPARROW SS, 1985, J PEDIATR PSYCHOL, V10, P215, DOI 10.1093/jpepsy/10.2.215 Spielberger C. D., 1983, MANUAL STATE TRAIT A Spielberger CD, 1972, MANUAL STATE TRAIT A Strang JF, 2012, RES AUTISM SPECT DIS, V6, P406, DOI 10.1016/j.rasd.2011.06.015 Taurines Regina, 2012, Atten Defic Hyperact Disord, V4, P115, DOI 10.1007/s12402-012-0086-2 Van Hecke A. V., 2013, J AUTISM DEV DISORDE, DOI 10.1007/s10803-013-1883-y van Steensel F. J., 2012, INT J RES PRACTICE, V17, P681 Walkup JT, 2008, NEW ENGL J MED, V359, P2753, DOI 10.1056/NEJMoa0804633 Wang J, 2013, SOC PSYCH PSYCH EPID, V48, P575, DOI 10.1007/s00127-012-0569-7 White SW, 2013, J AUTISM DEV DISORD, V43, P382, DOI 10.1007/s10803-012-1577-x Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x Yoo H. J., 2008, KOREAN VERSION SOCIA Yoo HJ, 2007, KOREAN VERSION AUTIS NR 61 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 145 EP 161 DI 10.1002/aur.1354 PG 17 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300015 PM 24408892 ER PT J AU Sesarini, CV Costa, L Naymark, M Granana, N Cajal, AR Coto, MG Pallia, RC Argibay, PF AF Sesarini, Carla V. Costa, Lucas Naymark, Muriel Granana, Nora Cajal, Andrea R. Garcia Coto, Miguel Pallia, Roberto C. Argibay, Pablo F. TI Evidence for Interaction Between Markers in GABA(A) Receptor Subunit Genes in an Argentinean Autism Spectrum Disorder Population SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder (ASD); GABA(A) receptor subunits polymorphisms; multifactor dimensionality reduction method; Argentinean population ID LINKAGE-DISEQUILIBRIUM; EPILEPSY; ASSOCIATION; SUSCEPTIBILITY; 15Q11-Q13; ABSENCE AB Autism spectrum disorders (ASD) can be conceptualized as a genetic dysfunction that disrupts development and function of brain circuits mediating social cognition and language. At least some forms of ASD may be associated with high level of excitation in neural circuits, and gamma-aminobutyric acid (GABA) has been implicated in its etiology. Single-nucleotide polymorphisms (SNP) located within the GABA receptor (GABAR) subunit genes GABRA1, GABRG2, GABRB3, and GABRD were screened. A hundred and thirty-six Argentinean ASD patients and 150 controls were studied, and the contribution of the SNPs in the etiology of ASD was evaluated independently and/or through gene-gene interaction using multifactor dimensionality reduction (MDR) method. From the 18 SNP studied, 11 were not present in our Argentinean population (patients and controls) and 1 SNP had minor allele frequency <0.1%. For the remaining six SNPs, none provided statistical significant association with ASD when considering allelic or genotypic frequencies. Non-significant association with ASD was found for the haplotype analysis. MDR identified evidence for synergy between markers in GABRB3 (chromosome 15) and GABRD (chromosome 1), suggesting potential gene-gene interaction across chromosomes associated with increased risk for autism (testing balanced accuracy: 0.6081 and cross-validation consistency: 10/10, P<0.001). Considering our Argentinean ASD sample, it can be inferred that GABRB3 would be involved in the etiology of autism through interaction with GABRD. These results support the hypothesis that GABAR subunit genes are involved in autism, most likely via complex gene-gene interactions. Autism Res2014, 7: 162-166. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Sesarini, Carla V.; Costa, Lucas; Cajal, Andrea R.; Argibay, Pablo F.] CABA, ICBME, Buenos Aires, DF, Argentina. [Naymark, Muriel; Pallia, Roberto C.] Hosp Italiano Buenos Aires, CABA, Buenos Aires, DF, Argentina. [Granana, Nora] Hosp Durand, CABA, Buenos Aires, DF, Argentina. [Garcia Coto, Miguel] CABA, Ctr Invest Desarrollo Psiconeurol CIDEP, Buenos Aires, DF, Argentina. RP Argibay, PF (reprint author), Hosp Italiano Buenos Aires, ICBME, CABA, Potosi 4240,C1199ACL, Buenos Aires, DF, Argentina. EM pablo.argibay@hospitalitaliano.org.ar FU Fundacion para el Desarrollo de las Ciencias Basicas (FUCIBA) FX Children and their parents involved in this study are gratefully acknowledged. Mariana Sigstad (Instituto Kanner), Marcelo Aguero (Fundacion TIPNEA), Pia Espoueys (Fundacion "Nuestro Angel"), and Flavia Caligiuri (CETDIN) are thanked for collecting samples. Nicolas Quiroz is gratefully acknowledged for graphics design. Fundacion para el Desarrollo de las Ciencias Basicas (FUCIBA) is gratefully thanked for it generous financial support. CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47 Ashley-Koch AE, 2006, ANN HUM GENET, V70, P281, DOI 10.1111/j.1469-1809.2006.00253.x Brooks-Kayal A, 2010, BRAIN DEV-JPN, V32, P731, DOI 10.1016/j.braindev.2010.04.010 Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011 Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552 Connolly JJ, 2013, CHILD DEV, V84, P17, DOI 10.1111/j.1467-8624.2012.01838.x Cook EH, 1998, AM J HUM GENET, V62, P1077, DOI 10.1086/301832 Dibbens LM, 2004, HUM MOL GENET, V13, P1315, DOI 10.1093/hmg/ddh146 Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0 Gepner B, 2009, NEUROSCI BIOBEHAV R, V33, P1227, DOI 10.1016/j.neubiorev.2009.06.006 Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009 Hahn LW, 2003, BIOINFORMATICS, V19, P376, DOI 10.1093/bioinformatics/btf869 Kumari R, 2011, CLIN CHIM ACTA, V412, P1244, DOI 10.1016/j.cca.2011.03.018 Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015 Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195 Martin ER, 2000, AM J MED GENET, V96, P43, DOI 10.1002/(SICI)1096-8628(20000207)96:1<43::AID-AJMG9>3.0.CO;2-3 Mendez MA, 2013, NEUROPHARMACOLOGY, V68, P195, DOI 10.1016/j.neuropharm.2012.04.008 Parmeggiani A, 2010, BRAIN DEV-JPN, V32, P783, DOI 10.1016/j.braindev.2010.07.003 Rossignol E., 2011, NEURAL PLASTICITY, V2011, DOI 10.1155/2011/649325 Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Salmon B, 1999, AM J MED GENET, V88, P551, DOI 10.1002/(SICI)1096-8628(19991015)88:5<551::AID-AJMG21>3.0.CO;2-# State MW, 2010, NEURON, V68, P254, DOI 10.1016/j.neuron.2010.10.004 Urak L, 2006, HUM MOL GENET, V15, P2533, DOI 10.1093/hmg/ddl174 NR 23 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 162 EP 166 DI 10.1002/aur.1353 PG 5 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300016 PM 24249596 ER PT J AU Bolte, S de Schipper, E Robison, JE Wong, VCN Selb, M Singhal, N de Vries, PJ Zwaigenbaum, L AF Bolte, Sven de Schipper, Elles Robison, John E. Wong, Virginia C. N. Selb, Melissa Singhal, Nidhi de Vries, Petrus J. Zwaigenbaum, Lonnie TI Classification of Functioning and Impairment: The Development of ICF Core Sets for Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE neurodevelopmental disorders; autistic disorder; assessment; children and youth; psychiatry; mental health; health care; ICF; ICF Core Set ID INTERNATIONAL-CLASSIFICATION; REHABILITATION-MEDICINE; CHILDREN; POPULATION; HEALTH; COMORBIDITY; PREVALENCE; DISABILITY; SAMPLE; ADULTS AB Given the variability seen in Autism Spectrum Disorder (ASD), accurate quantification of functioning is vital to studying outcome and quality of life in affected individuals. The International Classification of Functioning, Disability and Health (ICF) provides a comprehensive, universally accepted framework for the description of health-related functioning. ICF Core Sets are shortlists of ICF categories that are selected to capture those aspects of functioning that are most relevant when describing a person with a specific condition. In this paper, the authors preview the process for developing ICF Core Sets for ASD, a collaboration with the World Health Organization and the ICF Research Branch. The ICF Children and Youth version (ICF-CY) was derived from the ICF and designed to capture the specific situation of the developing child. As ASD affects individuals throughout the life span, and the ICF-CY includes all ICF categories, the ICF-CY will be used in this project (ICF(-CY) from now on). The ICF(-CY) categories to be included in the ICF Core Sets for ASD will be determined at an ICF Core Set Consensus Conference, where evidence from four preparatory studies (a systematic review, an expert survey, a patient and caregiver qualitative study, and a clinical cross-sectional study) will be integrated. Comprehensive and Brief ICF Core Sets for ASD will be developed with the goal of providing useful standards for research and clinical practice and generating a common language for functioning and impairment in ASD in different areas of life and across the life span. Autism Res 2014, 7: 167-172. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Bolte, Sven; de Schipper, Elles] Ctr Neurodev Disorders KIND, Dept Womens & Childrens Hlth, Neuropsychiat Unit, Stockholm, Sweden. [Bolte, Sven] Stockholm Cty Council, Div Child & Adolescent Psychiat, Stockholm, Sweden. [Robison, John E.] US Dept HHS, Interagcy Autism Coordinating Comm, Washington, DC 20201 USA. [Wong, Virginia C. N.] Univ Hong Kong, Div Pediat Neurol Dev Behav Paediat & NeuroHabili, Dept Pediat & Adolescent Med, Hong Kong, Hong Kong, Peoples R China. [Selb, Melissa] DIMDI, WHO Collaborating Ctr Family Int Classificat Germ, ICF Res Branch, Nottwil, Switzerland. [Selb, Melissa] Swiss Parapleg Res SPF, Nottwil, Switzerland. [Singhal, Nidhi] Act Autism, New Delhi, India. [de Vries, Petrus J.] Univ Cape Town, Div Child & Adolescent Psychiat, ZA-7925 Cape Town, South Africa. [Zwaigenbaum, Lonnie] Univ Alberta, Dept Pediat, Edmonton, AB, Canada. RP de Schipper, E (reprint author), Gavlegatan 22B,Plan 8, S-11330 Stockholm, Sweden. EM elles.de.schipper@ki.se FU Swedish Research Council [523-2009-7054]; VINNOVA [259-2012-24]; FAS; FORMAS FX The development of ICF Core Sets for ASD is supported by the Swedish Research Council (grant nr. 523-2009-7054), and the Swedish Research Council in partnership with FAS, FORMAS and VINNOVA (cross-disciplinary research program concerning children's and youth's mental health, grant nr. 259-2012-24). CR Alvarez AS, 2012, AM J PHYS MED REHAB, V91, pS69, DOI 10.1097/PHM.0b013e31823d4f1c American Psychiatric Association, 2000, DIAGN STAT MAN MENT [Anonymous], 1992, INT STAT CLASS DIS R Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Billstedt E, 2007, J CHILD PSYCHOL PSYC, V48, P1102, DOI 10.1111/j.1469-7610.2007.01774.x CASTRO S, 2013, DEV NEUROREHABILITAT, V16 Castro S, 2013, DISABIL REHABIL, V35, P125, DOI 10.3109/09638288.2012.690494 Cerniauskaite M, 2011, DISABIL REHABIL, V33, P281, DOI 10.3109/09638288.2010.529235 Cieza A, 2005, J REHABIL MED, V37, P212, DOI 10.1080/16501970510040263 Fayed N, 2011, DISABIL REHABIL, V33, P1941, DOI 10.3109/09638288.2011.553704 Gan SM, 2013, DISABIL REHABIL, V35, P678, DOI 10.3109/09638288.2012.705946 Ibragimova N, 2009, DEV NEUROREHABIL, V12, P3, DOI 10.1080/17518420902777001 Idring S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041280 Joshi G., 2012, J AUTISM DEV DISORD, V43, P1314 Joshi G, 2010, J AUTISM DEV DISORD, V40, P1361, DOI 10.1007/s10803-010-0996-9 Kanne SM, 2011, J AUTISM DEV DISORD, V41, P1007, DOI 10.1007/s10803-010-1126-4 Klitz U, 2011, RHEUMATOLOGY, V50, P894, DOI [10.1093/rheumatology/keq315, DOI 10.1093/RHEUMATOLOGY/KEQ315] Kostanjsek N, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-S4-S3 Kuhlthau K, 2010, J AUTISM DEV DISORD, V40, P721, DOI 10.1007/s10803-009-0921-2 Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3 Orsmond GI, 2004, J AUTISM DEV DISORD, V34, P245, DOI 10.1023/B:JADD.0000029547.96610.df Peyrin-Biroulet L, 2012, GUT, V61, P241, DOI 10.1136/gutjnl-2011-300049 Rauch A, 2012, ICF CORE SETS MANUAL, P4 Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b Shipman DL, 2011, J DEV BEHAV PEDIATR, V32, P85, DOI 10.1097/DBP.0b013e318203e558 Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f Stucki G, 2008, EUR J PHYS REHAB MED, V44, P299 Stucki G, 2004, J REHABIL MED, V36, P5, DOI 10.1080/16501960410022300 TRAVERNOR L, 2012, CHILD CARE HLTH DEV, V39, P592 Ustun B, 2004, J REHABIL MED, V36, P7, DOI 10.1080/16501960410015344 WHO, 2003, ICF CHECKL VERS 2 1A World Health Organisation, 2001, INT CLASS FUNCT DIS World Health Organization, 1992, INT CLASS DIS DIAGN World Health Organization (WHO), 2007, INT CLASS FUNCT DIS NR 34 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2014 VL 7 IS 1 BP 167 EP 172 DI 10.1002/aur.1335 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA AB3PI UT WOS:000331702300017 PM 24124074 ER PT J AU Williams, D Jarrold, C AF Williams, David Jarrold, Christopher TI Assessing Planning and Set-Shifting Abilities in Autism: Are Experimenter-Administered and Computerised Versions of Tasks Equivalent? SO AUTISM RESEARCH LA English DT Article DE autism; executive functioning; planning; set-shifting; Wisconsin Card Sorting Test; Tower of London task ID CARD SORTING TEST; SPECTRUM DISORDERS; DIAGNOSTIC INTERVIEW; CHILDREN AB Across studies, analysis of performance on classic measures of executive functioning (EF) among individuals with autism spectrum disorder (ASD) suggests that people with this disorder may be impaired only when tasks are experimenter-administered, but not when the same tasks are computer-administered. This would imply that the underlying cause of apparent executive dysfunction in ASD is a diminished ability to engage with another person/comprehend what another person expects, rather than a diminution of the control processes that typically underpin EF task performance. However, this suggestion is limited because, to our knowledge, no study has directly compared the equivalence of computer-administered and standard experimenter-administered versions of EF tasks that have been presented in counterbalanced order among a common sample of individuals with ASD. In the current study, 21 children with ASD and 22 age- and intelligence quotient (IQ)-matched comparison participants completed, in counterbalanced order, computerised and manual versions of both a planning task and a cognitive flexibility/set-shifting task. Contrary to expectation, results indicated that participants with ASD were equally impaired in terms of the key dependent variable on standard and computerised versions of both tasks. Practically, these results suggest that computer-administered and experimenter-administered versions of planning and set-shifting tasks are equivalent among individuals with ASD and can be used interchangeably in studies of EF among this population. Theoretically, these results challenge the notion that poor performance on EF tasks among school-aged children with ASD is only the result of a limited ability to engage with a human experimenter/comprehend socially presented rules. Autism Res 2013, 6: 461-647. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Williams, David] Univ Durham, Dept Psychol, Durham DH1 3LE, England. [Jarrold, Christopher] Univ Bristol, Sch Expt Psychol, Bristol, Avon, England. RP Williams, D (reprint author), Univ Kent, Sch Psychol, Canterbury CT2 7NP, Kent, England. EM d.m.williams@kent.ac.uk FU Economic and Social Research Council UK [RES-000-22-4125] FX This study was funded by an Economic and Social Research Council UK Grant awarded to David Williams and Christopher Jarrold (RES-000-22-4125). Published online 26 July 2013 in Wiley Online Library (wileyonlinelibrary.com) CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Barkley RA, 1997, PSYCHOL BULL, V121, P65, DOI 10.1037//0033-2909.121.1.65 Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777 Fernyhough C, 1996, NEW IDEAS PSYCHOL, V14, P47, DOI 10.1016/0732-118X(95)00024-B Hobson R. P., 2011, RES AUTISM SPECT DIS, P265 Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Luciana M, 1998, NEUROPSYCHOLOGIA, V36, P273, DOI 10.1016/S0028-3932(97)00109-7 NELSON HE, 1976, CORTEX, V12, P313 OWEN AM, 1990, NEUROPSYCHOLOGIA, V28, P1021, DOI 10.1016/0028-3932(90)90137-D OZONOFF S, 1995, NEUROPSYCHOLOGY, V9, P491, DOI 10.1037//0894-4105.9.4.491 Perner J, 2002, INFANT CHILD DEV, V11, P93, DOI 10.1002/icd.299 Russell J., 1996, AGENCY ITS ROLE MENT Russell J, 1999, J AUTISM DEV DISORD, V29, P103, DOI 10.1023/A:1023084425406 SHALLICE T, 1982, PHILOS T ROY SOC B, V298, P199, DOI 10.1098/rstb.1982.0082 Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008 Tabachnick BG, 2013, USING MULTIVARIATE S Vygotsky L. S., 1987, THINKING SPEECH COLL, V1 Wallace GL, 2009, J AUTISM DEV DISORD, V39, P1735, DOI 10.1007/s10803-009-0802-8 Wechsler D, 1999, WECHSLER ABBREVIATED White SJ, 2013, J AUTISM DEV DISORD, V43, P114, DOI 10.1007/s10803-012-1550-8 Williams D. M., 2012, DEV PSYCHOPATHOL, V24, P224 Winsler A, 2007, J AUTISM DEV DISORD, V37, P1617, DOI 10.1007/s10803-006-0294-8 World Health Organization, 1993, INT CLASS MENT BEH D NR 26 TC 3 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 461 EP 467 DI 10.1002/aur.1311 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900001 PM 23893967 ER PT J AU Tager-Flusberg, H Kasari, C AF Tager-Flusberg, Helen Kasari, Connie TI Minimally Verbal School-Aged Children with Autism Spectrum Disorder: The Neglected End of the Spectrum SO AUTISM RESEARCH LA English DT Review DE behavioral intervention < intervention; early intervention < intervention; school age < pediatrics; spoken language; minimally verbal ASD; alternative and augmentative communication; eye-tracking ID COMMUNICATION-SYSTEM PECS; EVENT-RELATED POTENTIALS; DEVELOPMENTAL DELAYS; LANGUAGE ASSESSMENT; JOINT ATTENTION; YOUNG-CHILDREN; BRAIN ACTIVITY; EYE-TRACKING; SPEECH; INTERVENTIONS AB It is currently estimated that about 30% of children with autism spectrum disorder remain minimally verbal, even after receiving years of interventions and a range of educational opportunities. Very little is known about the individuals at this end of the autism spectrum, in part because this is a highly variable population with no single set of defining characteristics or patterns of skills or deficits, and in part because it is extremely challenging to provide reliable or valid assessments of their developmental functioning. In this paper, we summarize current knowledge based on research including minimally verbal children. We review promising new novel methods for assessing the verbal and nonverbal abilities of minimally verbal school-aged children, including eye-tracking and brain-imaging methods that do not require overt responses. We then review what is known about interventions that may be effective in improving language and communication skills, including discussion of both nonaugmentative and augmentative methods. In the final section of the paper, we discuss the gaps in the literature and needs for future research. Autism Res 2013, 6: 468-478. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Tager-Flusberg, Helen] Boston Univ, Dept Psychol, Boston, MA 02215 USA. [Tager-Flusberg, Helen] Boston Univ, Dept Anat & Neurobiol, Boston, MA 02215 USA. [Kasari, Connie] Univ Calif Los Angeles, Grad Sch Educ, Los Angeles, CA 90024 USA. RP Tager-Flusberg, H (reprint author), Boston Univ, Dept Psychol, 64 Cummington St, Boston, MA 02215 USA. EM htagerf@bu.edu FU National Institutes of Health (NIH) [NIDCD RO1 DC 10290-S1, P50 DC 13027, NIMH R01 MH084864]; Autism Speaks [2468]; Autism Speaks Hi Risk/Hi Impact [5666]; HRSA [UA3MC11055] FX Support for preparation of this paper was provided by grants from the National Institutes of Health (NIH) (NIDCD RO1 DC 10290-S1; P50 DC 13027) and Autism Speaks (#2468) to HTF and NIH (NIMH R01 MH084864), Autism Speaks Hi Risk/Hi Impact (#5666) and HRSA (UA3MC11055) to C.K. Published online 7 October 2013 in Wiley Online Library (wileyonlinelibrary.com) CR Anderson DK, 2007, J CONSULT CLIN PSYCH, V75, P594, DOI 10.1037/0022-006X.75.4.594 Aslin RN, 2004, INFANCY, V6, P155, DOI 10.1207/s15327078in0602_1 Aslin RN, 2007, DEVELOPMENTAL SCI, V10, P48, DOI 10.1111/j.1467-7687.2007.00563.x Bailey AJ, 2005, EUR J NEUROSCI, V21, P2575, DOI 10.1111/j.1460-9568.2005.04061.x Benasich A., 2011, INT M AUT RES SAN DI Bishop DVM, 2007, PSYCHOL BULL, V133, P651, DOI 10.1037/0033-2909.133.4.651 Bopp KD, 2009, J SPEECH LANG HEAR R, V52, P1106, DOI 10.1044/1092-4388(2009/07-0262) Boraston Z, 2007, J PHYSIOL-LONDON, V581, P893, DOI 10.1113/jphysiol.2007.133587 Brady N., 2010, NIH WORKSH NONV SCH BRYSON SE, 1994, J AUTISM DEV DISORD, V24, P225, DOI 10.1007/BF02172099 Byrne JM, 1999, DEV MED CHILD NEUROL, V41, P740, DOI 10.1017/S0012162299001504 Charlop-Christy MH, 2002, J APPL BEHAV ANAL, V35, P213, DOI 10.1901/jaba.2002.35-213 Chawarska K, 2010, ARCH GEN PSYCHIAT, V67, P178, DOI 10.1001/archgenpsychiatry.2009.194 Choudhury N, 2011, CLIN NEUROPHYSIOL, V122, P320, DOI 10.1016/j.clinph.2010.05.035 Collins LM, 2007, AM J PREV MED, V32, pS112, DOI 10.1016/j.amepre.2007.01.022 Connolly J., 2011, INT M AUT RES SAN DI Connolly JF, 2006, J CLIN EXP NEUROPSYC, V28, P1327, DOI 10.1080/13803390500428484 Dawson G., 2010, PEDIATRICS, V125, P17 Edelson L., 2008, INT M AUT RES LOND E Flax JF, 2010, J NEURODEV DISORD, V2, P210, DOI 10.1007/s11689-010-9063-2 Friederici AD, 2005, TRENDS COGN SCI, V9, P481, DOI 10.1016/j.tics.2005.08.008 Friedrich M, 2010, BRAIN LANG, V114, P66, DOI 10.1016/j.bandl.2009.07.004 Gage N., 2011, INT M AUT RES SAN DI Gage NM, 2003, DEV BRAIN RES, V144, P201, DOI 10.1016/S0165-3806(03)00172-X Gernsbacher MA, 2008, J CHILD PSYCHOL PSYC, V49, P43, DOI 10.1111/j.1469-7610.2007.01820.x Gordon B., 2010, NIH WORKSH NONV SCH Gordon K, 2011, J CONSULT CLIN PSYCH, V79, P447, DOI 10.1037/a0024379 Hari R, 2010, ANN NY ACAD SCI, V1191, P89, DOI 10.1111/j.1749-6632.2010.05438.x Howlin P, 2007, J CHILD PSYCHOL PSYC, V48, P473, DOI 10.1111/j.1469-7610.2006.01707.x Howlin P, 2009, AJIDD-AM J INTELLECT, V114, P23, DOI 10.1352/2009.114:23;nd41 Imada T, 2006, NEUROREPORT, V17, P957, DOI 10.1097/01.wnr.0000223387.51704.89 Jeste SS, 2009, J AUTISM DEV DISORD, V39, P495, DOI 10.1007/s10803-008-0652-9 Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125 Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895 Knaus TA, 2010, BRAIN LANG, V112, P113, DOI 10.1016/j.bandl.2009.11.005 Koegel RL, 2009, J AUTISM DEV DISORD, V39, P1587, DOI 10.1007/s10803-009-0765-9 Kotz SA, 2003, J NEUROLINGUIST, V16, P43, DOI 10.1016/S0911-6044(02)00008-8 Kutas M, 2011, ANNU REV PSYCHOL, V62, P621, DOI 10.1146/annurev.psych.093008.131123 Lord C., 2010, NIH WORKSH NONV SCH LOVAAS OI, 1987, J CONSULT CLIN PSYCH, V55, P3, DOI 10.1037/0022-006X.55.1.3 Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1 Mancil GR, 2009, J AUTISM DEV DISORD, V39, P149, DOI 10.1007/s10803-008-0613-3 Munson J., 2008, AM J MENT RETARD, V113, P438 National Research Council, 2001, ED CHILDR AUT Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369 Pickett A., 2009, COGN BEHAV NEUROL, V22, P1 Preston D, 2009, J AUTISM DEV DISORD, V39, P1471, DOI 10.1007/s10803-009-0763-y Rapin I, 2009, DEV NEUROPSYCHOL, V34, P66, DOI 10.1080/87565640802564648 Redcay E, 2008, BIOL PSYCHIAT, V64, P589, DOI 10.1016/j.biopsych.2008.05.020 Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111 Romski M, 2010, J SPEECH LANG HEAR R, V53, P350, DOI 10.1044/1092-4388(2009/08-0156) Schlosser RW, 2008, AM J SPEECH-LANG PAT, V17, P212, DOI 10.1044/1058-0360(2008/021) Schreibman L., 2010, NIH WORKSH NONV SCH Sherer MR, 2005, J CONSULT CLIN PSYCH, V73, P525, DOI 10.1037/0022-006X.73.3.525 Sigafoos J, 2004, DISABIL REHABIL, V26, P1330, DOI 10.1080/09638280412331280361 Sigman M, 1999, MONOGR SOC RES CHILD, V64, P1, DOI 10.1111/1540-5834.00002 Sigman M, 2005, J AUTISM DEV DISORD, V35, P15, DOI 10.1007/s10803-004-1027-5 Stone WL, 2001, AUTISM, V5, P341, DOI 10.1177/1362361301005004002 Sulzer-Azaroff B, 2009, FOCUS AUTISM DEV DIS, V24, P89, DOI 10.1177/1088357609332743 Tager-Flusberg H., 2005, AUTISM PERVASIVE DEV, V1, P335 Tager-Flusberg H., 1999, METHODS STUDYING LAN, P313 Takarae Y, 2007, PSYCHIAT RES-NEUROIM, V156, P117, DOI 10.1016/j.pseychresns.2007.03.008 Thurm A., 2007, J AUTISM DEV DISORD, V37, P1731 Turner LM, 2006, AUTISM, V10, P243, DOI 10.1177/1362361306063296 Wan C. Y., 2010, FUTURE NEUROL, V5, P797, DOI 10.2217/fnl.10.55 Yoder P, 2006, J SPEECH LANG HEAR R, V49, P698, DOI 10.1044/1092-4388(2006/051) NR 67 TC 10 Z9 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 468 EP 478 DI 10.1002/aur.1329 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900002 PM 24124067 ER PT J AU Kasari, C Brady, N Lord, C Tager-Flusberg, H AF Kasari, Connie Brady, Nancy Lord, Catherine Tager-Flusberg, Helen TI Assessing the Minimally Verbal School-Aged Child With Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Review DE minimally verbal; school-aged children; assessment; communication ID PERVASIVE DEVELOPMENTAL DISORDERS; YOUNG-CHILDREN; JOINT ATTENTION; SYMBOLIC PLAY; COMMUNICATIVE COMPETENCES; SOCIAL COMMUNICATION; DIAGNOSTIC INTERVIEW; EXPRESSIVE LANGUAGE; PREDICTIVE-VALIDITY; PRESCHOOL-CHILDREN AB This paper addresses the issue of assessing communication, language, and associated cognitive and behavioral abilities of minimally verbal children with autism spectrum disorder (ASD), presenting a summary of a year-long series of meetings held by a group of experts in the field of ASD and National Institutes of Health staff. In this paper, our goals were to first define the population and then present general guidelines for optimizing assessment sessions for this challenging population. We then summarize the available measures that can be used across a variety of behavioral domains that are most directly relevant to developing language skills, including oral motor skills, vocal repertoire, receptive and expressive language, imitation, intentional communication, play, social behavior, repetitive and sensory behaviors, and nonverbal cognition. We conclude with a discussion of some of the limitations in the available measures and highlight recommendations for future research in this area. Autism Res 2013, 6: 479-493. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Kasari, Connie] Univ Calif Los Angeles, Dept Human Dev & Psychol, Los Angeles, CA 90024 USA. [Kasari, Connie] Univ Calif Los Angeles, Ctr Autism Res & Treatment, Los Angeles, CA 90024 USA. [Brady, Nancy] Univ Kansas, Dept Psychol, Lawrence, KS 66045 USA. [Lord, Catherine] Cornell Weill Med Ctr, Dept Psychiat, New York, NY USA. [Tager-Flusberg, Helen] Boston Univ, Dept Psychol, Boston, MA 02215 USA. RP Kasari, C (reprint author), Univ Calif Los Angeles, Ctr Autism Res & Treatment, Semel Inst 68 268, Los Angeles, CA 90024 USA. EM ckasari@mednet.ucla.edu FU NIH [NIDCD RO1 DC 10290-S1, NIMH R01 MH084864]; Autism Speaks [2468]; Autism Speaks Hi Risk/Hi Impact [5666]; HRSA [UA3MC11055] FX Support for preparation of this paper was provided by grants from NIH (NIDCD RO1 DC 10290-S1) and Autism Speaks (#2468) to HTF and NIH (NIMH R01 MH084864), Autism Speaks Hi Risk/Hi Impact (#5666) and HRSA (UA3MC11055) to CK. CR AMAN MG, 1985, AM J MENT DEF, V89, P485 American Psychiatric Association, 2013, DIAGN STAT MAN MENT Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444 Bodfish J., 2003, INTERESTS SCAL UNPUB Bodfish J. W., 1999, W CAROLINA CTR RES R Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855 Boyd B., 2007, DIRECT OBSERVATION R Brady NC, 2012, AM J SPEECH-LANG PAT, V21, P16, DOI 10.1044/1058-0360(2011/10-0099) Brady NC, 2004, J SPEECH LANG HEAR R, V47, P663, DOI 10.1044/1092-4388(2004/051) Brown C, 2002, ADOLESCENT ADULT SEN Bruckner C, 2007, J SPEECH LANG HEAR R, V50, P1631, DOI 10.1044/1092-4388(2007/110) Bruininks R., 1996, SCALES INDEPENDENT B Chandler S, 2007, J AM ACAD CHILD PSY, V46, P1324, DOI 10.1097/chi.0b013e31812f7d8d Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x Cohen I. L., 2005, PDD BEHAV INVENTORY Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 Constantino JN, 2005, SOCIAL RESPONSIVENES Costanza-Smith A., 2010, PERSPECTIVES LANGUAG, V17, P9 Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x DOSWELL G, 1994, EUR J DISORDER COMM, V29, P289 Dunn LM, 2004, PEABODY PICTURE VOCA Dunn W, 1999, SENSORY PROFILE USER Edwards S., 1999, REYNELL DEV LANGUAGE Einfeld S. L., 2002, MANUAL DEV BEHAV CHE EINFELD SL, 1995, J AUTISM DEV DISORD, V25, P81, DOI 10.1007/BF02178498 Elliott C., 2007, DIFFERENTIAL ABILITY Feldman HM, 2005, CHILD DEV, V76, P856, DOI 10.1111/j.1467-8624.2005.00882.x Fenson L., 2006, MACARTHUR BATES COMM Fewell R. R., 1987, J PSYCHOEDUCATIONAL, V5, P107, DOI 10.1177/073428298700500203 Fey ME, 2006, J SPEECH LANG HEAR R, V49, P526, DOI 10.1044/1092-4388(2006/039) Freitag CM, 2006, EUR CHILD ADOLES PSY, V15, P282, DOI 10.1007/s00787-006-0533-8 Gernsbacher MA, 2008, J CHILD PSYCHOL PSYC, V49, P43, DOI 10.1111/j.1469-7610.2007.01820.x Goldstein S, 2009, ASSESSMENT AUTISM SP Hedrick D. L., 1984, SEQUENCED INVENTORY Hobson JA, 2007, DEV PSYCHOPATHOL, V19, P411, DOI 10.1017/S0954579407070204 Hresko W. P., 1999, TEST EARLY LANGUAGE Iacono T, 2009, J INTELL DISABIL RES, V53, P44, DOI 10.1111/j.1365-2788.2008.01121.x Iacono T, 2005, J INTELLECT DEV DIS, V30, P139, DOI 10.1080/13668250500204059 Jahromi LB, 2009, J AUTISM DEV DISORD, V39, P395, DOI 10.1007/s10803-008-0636-9 Kaiser AP, 2013, J SPEECH LANG HEAR R, V56, P295, DOI 10.1044/1092-4388(2012/11-0231) Kasari C., 2005, CLIN NEUROPSYCHIATRY, V2, P380, DOI DOI 10.1007/S10803-010-0955-5 Kasari C, 2006, J CHILD PSYCHOL PSYC, V47, P611, DOI 10.1111/j.1469-7610.2005.01567.x Kover ST, 2012, J SPEECH LANG HEAR R, V55, P1022, DOI 10.1044/1092-4388(2011/11-0075) Le Couteur A., 2003, AUTISM DIAGNOSTIC IN Lifter K., 1988, DEV PLAY ASSES UNPUB Linder T. W., 1993, TRANSDISCIPLINARY PL Lord C., 1999, AUTISM DIAGNOSTIC OB LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Maloney E. S., 2007, CONT ISSUES COMMUNIC, V34, P86 Matson JL, 2007, RES DEV DISABIL, V28, P567, DOI 10.1016/j.ridd.2006.08.001 Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8 Mesibov G. B., 2007, TTAP TEACCH TRANSITI Mirenda P, 2003, LANG SPEECH HEAR SER, V34, P203, DOI 10.1044/0161-1461(2003/017) Mosconi MW, 2009, J AUTISM DEV DISORD, V39, P242, DOI 10.1007/s10803-008-0620-4 Mullen E, 1995, MULLEN SCALES EARLY Mundy P., 2003, EARLY SOCIAL COMMUNI O'Neill D., 2002, J SPEECH LANG HEAR R, V50, P214 Paul R., 2008, LEWISS CHILD ADOLESC, P371 Pickett E, 2009, COGN BEHAV NEUROL, V22, P1, DOI 10.1097/WNN.0b013e318190d185 Raven J., 1998, MANUAL RAVENS PROGR Reynolds C. R., 2002, CLIN GUIDE BEHAV ASS Rice ML, 2006, J SPEECH LANG HEAR R, V49, P793, DOI 10.1044/1092-4388(2006/056) Rimland B., 2000, AUTISM TREATMENT EVA Roeyers H, 1998, DEV PSYCHOPATHOL, V10, P441, DOI 10.1017/S0954579498001680 Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162 Roid G., 1997, LEITER INT PERFORMAN Rojahn J, 2001, J AUTISM DEV DISORD, V31, P577, DOI 10.1023/A:1013299028321 Rojas R., 2010, PERSPECTIVES LANGUAG, V17, P24 Romski M, 2010, J SPEECH LANG HEAR R, V53, P350, DOI 10.1044/1092-4388(2009/08-0156) Rowland C., 2008, ONLINE COMMUNICATION Rutter M., 2003, SOCIAL COMMUNICATION Schopler E., 2005, PSYCHOEDUCATIONAL PR Schopler E., 2010, CHILDHOOD AUTISM RAT, VSecond Sigafoos J, 2000, COMMUNICATION DISORD, V21, P77, DOI 10.1177/152574010002100202 Sigman M, 1999, MONOGR SOC RES CHILD, P64 Siller M, 2008, DEV PSYCHOL, V44, P1691, DOI 10.1037/a0013771 Sparrow SS, 2005, VINELAND ADAPTIVE BE Stagnitti K, 2007, CHILD INITIATED PRET Stone WL, 1997, J ABNORM CHILD PSYCH, V25, P475, DOI 10.1023/A:1022685731726 Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136) Tellegen P, 1993, EUROPEAN J PSYCHOL A, V9, P147 Thurm A, 2007, J AUTISM DEV DISORD, V37, P1721, DOI 10.1007/s10803-006-0300-1 Toth K, 2006, J AUTISM DEV DISORD, V36, P993, DOI 10.1007/s10803-006-0137-7 Turner M., 1995, THESIS U CAMBRIDGE UNGERER JA, 1981, J AM ACAD CHILD PSY, V20, P318, DOI 10.1016/S0002-7138(09)60992-4 Watt N, 2008, J AUTISM DEV DISORD, V38, P1518, DOI 10.1007/s10803-007-0532-8 Zimmerman I. L., 2011, PRESCHOOL LANGUAGE S NR 87 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 479 EP 493 DI 10.1002/aur.1334 PG 15 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900003 PM 24353165 ER PT J AU Faja, S Murias, M Beauchaine, TP Dawson, G AF Faja, Susan Murias, Michael Beauchaine, Theodore P. Dawson, Geraldine TI Reward-Based Decision Making and Electrodermal Responding by Young Children with Autism Spectrum Disorders during a Gambling Task SO AUTISM RESEARCH LA English DT Article DE autism; reward; executive function; decision making; repetitive behavior; internalizing; electrodermal response ID VENTROMEDIAL PREFRONTAL CORTEX; SKIN-CONDUCTANCE ANALYSIS; EXECUTIVE FUNCTION; HEART-RATE; AMYGDALA; ADOLESCENTS; BEHAVIOR; CONSEQUENCES; METAANALYSIS; PERFORMANCE AB In this study, we explore reward-based decision making and electrodermal responding (EDR) among children with autism spectrum disorder (ASD) during a children's gambling task. In addition, we examine whether individual behavioral and EDR responses predict social communication, repetitive symptoms, parent reports of executive function, and behavioral challenges. The ability to form advantageous strategies for long-term gain is of interest for children with ASD, who exhibit both difficulty with executive function and atypical responses to reward. Twenty-one children ages 6-7 years with ASD and no intellectual disability, and 21 age- and IQ-matched typically developing children participated. Both groups exhibited a similar pattern of gambling selections, but children with ASD showed less knowledge of the reward contingencies of the decks after playing. In addition, although EDR was similar between groups in anticipation of selections, children with ASD exhibited greater EDR during feedback about rewards as the task progressed. Children with ASD who exhibited the greatest increases in EDR were more likely to exhibit repetitive symptoms, particularly rituals and the need for sameness, as well as internalizing behaviors and reduced executive function in other settings. Autism Res 2013, 6: 494-505. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Faja, Susan; Murias, Michael] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Beauchaine, Theodore P.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA. [Dawson, Geraldine] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA. RP Faja, S (reprint author), Univ Washington, Dept Psychiat & Behav Sci, Box 357920, Seattle, WA 98195 USA. EM susfaja@uw.edu FU American Psychological Association Dissertation Award; International Society of Autism Research Dissertation Award; Robert C. Bolles Graduate Fellowship; Cure Autism Now Young Investigator Award FX Grant sponsors: American Psychological Association Dissertation Award (S. F.), International Society of Autism Research Dissertation Award (S. F.), Robert C. Bolles Graduate Fellowship (S. F.), and Cure Autism Now Young Investigator Award (M.M.). CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Amiez C, 2003, EXP BRAIN RES, V149, P267, DOI 10.1007/s00221-002-1353-9 Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002 Bechara A, 1996, CEREB CORTEX, V6, P215, DOI 10.1093/cercor/6.2.215 Bechara A, 1999, J NEUROSCI, V19, P5473 BECHARA A, 1994, COGNITION, V50, P7, DOI 10.1016/0010-0277(94)90018-3 Bechara A, 1997, SCIENCE, V275, P1293, DOI 10.1126/science.275.5304.1293 Bodfish J. W., 1999, W CAROLINA CTR RES R Bunch KM, 2007, COGNITIVE DEV, V22, P376, DOI 10.1016/j.cogdev.2007.01.004 Carter S, 2004, COGNITION EMOTION, V18, P901, DOI 10.1080/02699930341000338 Cascio C. J., 2012, J NEURODEVELOPMENTAL, V4, P2 Casey BJ, 2000, BIOL PSYCHOL, V54, P241, DOI 10.1016/S0301-0511(00)00058-2 Crone EA, 2007, CHILD DEV, V78, P1288, DOI 10.1111/j.1467-8624.2007.01066.x Crone EA, 2004, DEV NEUROPSYCHOL, V25, P251, DOI 10.1207/s15326942dn2503_2 Crone EA, 2005, CHILD NEUROPSYCHOL, V11, P245, DOI 10.1080/092970490911261 Crone EA, 2004, PSYCHOPHYSIOLOGY, V41, P531, DOI 10.1111/j.1469-8986.2004.00197.x DAMASIO AR, 1991, FRONTAL LOBE FUNCTION AND DYSFUNCTION, P217 Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6 Dawson G, 1998, CHILD DEV, V69, P1276, DOI 10.2307/1132265 Dawson G, 1996, J AUTISM DEV DISORD, V26, P179, DOI 10.1007/BF02172008 Dichter GS, 2012, SOC COGN AFFECT NEUR, V7, P160, DOI 10.1093/scan/nsq095 Diekhof EK, 2012, NEUROPSYCHOLOGIA, V50, P1252, DOI 10.1016/j.neuropsychologia.2012.02.007 Elliott C., 2007, DIFFERENTIAL ABILITY Garon N, 2007, DEV NEUROPSYCHOL, V31, P39, DOI 10.1207/s15326942dn3101_3 Garon N, 2004, BRAIN COGNITION, V55, P158, DOI 10.1016/s0278-2626(03)00272-0 Gioia GA, 2000, CHILD NEUROPSYCHOL, V6, P235, DOI 10.1076/chin.6.3.235.3152 Glascher J, 2012, P NATL ACAD SCI USA, V109, P14681, DOI 10.1073/pnas.1206608109 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Grabenhorst F, 2011, TRENDS COGN SCI, V15, P56, DOI 10.1016/j.tics.2010.12.004 Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003 Holland PC, 2004, CURR OPIN NEUROBIOL, V14, P148, DOI 10.1016/j.conb.2004.03.007 Hongwanishkul D, 2005, DEV NEUROPSYCHOL, V28, P617, DOI 10.1207/s15326942dn2802_4 Hooper CJ, 2004, DEV PSYCHOL, V40, P1148, DOI 10.1037/0012-1649.40.6.1148 Huizenga HM, 2007, DEVELOPMENTAL SCI, V10, P814, DOI 10.1111/j.1467-7687.2007.00621.x Johnson SA, 2006, J INT NEUROPSYCH SOC, V12, P668, DOI 10.1017/S1355617706060802 Jones EJH, 2013, DEV NEUROPSYCHOL, V38, P58, DOI 10.1080/87565641.2012.727049 Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7 Kerr A, 2004, BRAIN COGNITION, V55, P148, DOI 10.1016/s0278-2626(03)00275-6 Klin A, 2007, RES PRACT PERS SEV D, V32, P89 Kohls G, 2011, J AUTISM DEV DISORD, V41, P1523, DOI 10.1007/s10803-011-1177-1 Kohls G, 2013, SOC COGN AFFECT NEUR, V8, P565, DOI 10.1093/scan/nss033 Kohls G, 2012, J NEURODEVELOPMENTAL, V4, P1 Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x Larson MJ, 2011, PSYCHIAT RES, V187, P198, DOI 10.1016/j.psychres.2010.11.006 Lord C., 2002, AUTISM DIAGNOSTIC OB McPartland J. C., 2012, J NEURODEVELOPMENTAL, V4, P1 Metcalfe J, 1999, PSYCHOL REV, V106, P3, DOI 10.1037/0033-295X.106.1.3 Neuhaus E, 2010, CLIN PSYCHOL REV, V30, P733, DOI 10.1016/j.cpr.2010.05.007 Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x Raudenbush S. W., 2004, HLM 6 WINDOWS Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd Rutter M., 2003, ADI R AUTISM DIAGNOS Schmitz N, 2008, BRIT J PSYCHIAT, V192, P19, DOI 10.1192/bjp.bp.107.036921 Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122 South M, 2011, J AUTISM DEV DISORD, V41, P55, DOI 10.1007/s10803-010-1021-z South M, 2008, J INT NEUROPSYCH SOC, V14, P42, DOI 10.1017/S1355617708080107 Sparrow S, 1984, VINELAND ADAPTIVE BE Stuss DT, 2011, J INT NEUROPSYCH SOC, V17, P759, DOI 10.1017/S1355617711000695 van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0 Yassa MA, 2012, J PSYCHIATR RES, V46, P1045, DOI 10.1016/j.jpsychires.2012.04.013 Yechiam E, 2010, BRAIN COGNITION, V72, P317, DOI 10.1016/j.bandc.2009.10.005 Zelazo P. D., 2002, HDB CHILDHOOD COGNIT, P445, DOI DOI 10.1002/9780470996652.CH20 NR 62 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 494 EP 505 DI 10.1002/aur.1307 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900004 PM 23893954 ER PT J AU Schneider, K Regenbogen, C Pauly, KD Gossen, A Schneider, DA Mevissen, L Michel, TM Gur, RC Habel, U Schneider, F AF Schneider, Karla Regenbogen, Christina Pauly, Katharina D. Gossen, Anna Schneider, Daniel A. Mevissen, Lea Michel, Tanja M. Gur, Ruben C. Habel, Ute Schneider, Frank TI Evidence for Gender-Specific Endophenotypes in High-Functioning Autism Spectrum Disorder During Empathy SO AUTISM RESEARCH LA English DT Article DE autism; empathy; gender differences; fMRI; social interactions ID MIRROR-NEURON SYSTEM; FACIAL EXPRESSIONS; ASPERGER SYNDROME; SEX-DIFFERENCES; EARLY-CHILDHOOD; BRAIN; GIRLS; MIND; ALEXITHYMIA; ATTENTION AB Despite remarkable behavioral gender differences in patients with autism spectrum disorder (ASD), and growing evidence for a diminished male:female ratio for the putative male disorder ASD, aspects of gender are not addressed accordingly in ASD research. Our study aims at filling this gap by exploring empathy abilities in a group of 28 patients with high-functioning ASD and 28 gender-, age- and education-matched non-autistic subjects, for the first time by means of functional neuroimaging (fMRI). In an event-related fMRI paradigm, emotional (E) and neutral (N) video clips presented actors telling self-related short stories. After each clip, participants were asked to indicate their own emotion and its intensity as well as the emotion and intensity perceived for the actor. Behaviorally, we found significantly less empathic responses in the overall ASD group compared with non-autistic subjects, and inadequate emotion recognition for the neutral clips in the female ASD group compared with healthy women. Neurally, increased activation of the bilateral medial frontal gyrus was found in male patients compared with female patients, a pattern which was not present in the non-autistic group. Additionally, autistic women exhibited decreased activation of midbrain and limbic regions compared with non-autistic women, whereas there was no significant difference within the male group. While we did not find a fundamental empathic deficit in autistic patients, our data propose different ways of processing empathy in autistic men and women, suggesting stronger impairments in cognitive aspects of empathy/theory of mind for men, and alterations of social reciprocity for women. Autism Res 2013, 6: 506-521. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Schneider, Karla; Regenbogen, Christina; Pauly, Katharina D.; Gossen, Anna; Schneider, Daniel A.; Mevissen, Lea; Michel, Tanja M.; Habel, Ute; Schneider, Frank] Rhein Westfal TH Aachen, Sch Med, Dept Psychiat Psychotherapy & Psychosomat, D-52074 Aachen, Germany. [Schneider, Karla; Regenbogen, Christina; Pauly, Katharina D.; Gossen, Anna; Schneider, Daniel A.; Habel, Ute; Schneider, Frank] JARA Translat Brain Med, Aachen, Germany. [Gur, Ruben C.; Schneider, Frank] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Gur, Ruben C.; Schneider, Frank] Philadelphia Vet Adm Med Ctr, Philadelphia, PA USA. [Michel, Tanja M.] Univ Rostock, Dept Psychiat & Psychotherapy, D-18055 Rostock, Germany. RP Schneider, K (reprint author), Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Pauwelsstr 30, D-52074 Aachen, Germany. EM karla.schneider@rwth-aachen.de FU German Research Foundation (DFG, International Research Training Group 1328: "Brain-behavior relationship of emotion and social cognition in schizophrenia and autism") [KFO 112, HA 3202/7-1]; Interdisciplinary Center for Clinical Research of the Medical Faculty of the RWTH Aachen University [IZKF, N2-6] FX 1. Grant sponsor: German Research Foundation (DFG, International Research Training Group 1328: "Brain-behavior relationship of emotion and social cognition in schizophrenia and autism") Grant Number: KFO 112 and HA 3202/7-12. Grant sponsor: Interdisciplinary Center for Clinical Research of the Medical Faculty of the RWTH Aachen University Grant number: IZKF, N2-6 CR Aschenbrenner S, 2001, REGENSBURGER WORTFLU Attwood T., 2008, COMPLETE GUIDE ASPER BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1 Baird G, 2000, J AM ACAD CHILD PSY, V39, P694, DOI 10.1097/00004583-200006000-00007 Barkley R., 1998, J CHILD PSYCHOL PSYC, V30, P379 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6 Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x Bartels A, 2004, NEUROIMAGE, V21, P1155, DOI 10.1016/j.neuroimage.2003.11.003 Bartley Jane J, 2006, Gend Med, V3, P73, DOI 10.1016/S1550-8579(06)80197-X Beacher FD, 2011, AM J NEURORADIOL, V33, P83, DOI DOI 10.3174/AJNR.A2880 Bejerot S, 2012, BRIT J PSYCHIAT, V201, P116, DOI 10.1192/bjp.bp.111.097899 Bird G, 2010, BRAIN, V133, P1515, DOI 10.1093/brain/awq060 Bloss CS, 2007, J AM ACAD CHILD PSY, V46, P515, DOI 10.1097/chi.0b013e318030e28b Borkenau P., 1993, NEO FUNF FAKTOREN IN Buddeberg-Fischer B, 2003, SWISS MED WKLY, V133, P535 Bzdok D, 2012, CEREB CORTEX, V22, P951, DOI 10.1093/cercor/bhr166 Calderoni S, 2012, NEUROIMAGE, V59, P1013, DOI 10.1016/j.neuroimage.2011.08.070 Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082 Cheng YW, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002113 Cheng Y, 2009, NEUROSCIENCE, V158, P713, DOI 10.1016/j.neuroscience.2008.10.026 Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007 Chevallier C, 2011, NEUROPSYCHOLOGIA, V49, P507, DOI 10.1016/j.neuropsychologia.2010.11.042 Cox RW, 2012, NEUROIMAGE, V62, P743, DOI 10.1016/j.neuroimage.2011.08.056 Craig MC, 2007, BRIT J PSYCHIAT, V191, P224, DOI 10.1192/bjp.bp.106.034603 de Vries ALC, 2010, J AUTISM DEV DISORD, V40, P930, DOI 10.1007/s10803-010-0935-9 Dichter GS, 2009, SOC COGN AFFECT NEUR, V4, P215, DOI 10.1093/scan/nsp017 Dworzynski K, 2012, J AM ACAD CHILD PSY, V51, P788, DOI 10.1016/j.jaac.2012.05.018 EHLERS S, 1993, J CHILD PSYCHOL PSYC, V34, P1327, DOI 10.1111/j.1469-7610.1993.tb02094.x Eigsti IM, 2012, CHILD NEUROPSYCHOL, V18, P600, DOI 10.1080/09297049.2011.639757 Farley A, 2010, AUTISM, V14, P519, DOI 10.1177/1362361310368536 Fields HL, 2007, ANNU REV NEUROSCI, V30, P289, DOI 10.1146/annurev.neuro.30.051606.094341 Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3 FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8 HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56 Harenski CL, 2008, SOC COGN AFFECT NEUR, V3, P313, DOI 10.1093/scan/nsn026 Herve PY, 2012, NEUROIMAGE, V61, P1255, DOI 10.1016/j.neuroimage.2012.03.073 Hooker CI, 2010, BRAIN RES, V1308, P100, DOI 10.1016/j.brainres.2009.10.006 Horowitz L. M., 2000, INVENTAR ERFASSUNG I Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103 Kim JW, 2009, NEUROPSYCHOLOGIA, V47, P2073, DOI 10.1016/j.neuropsychologia.2009.03.017 Koch K, 2007, NEUROPSYCHOLOGIA, V45, P2744, DOI 10.1016/j.neuropsychologia.2007.04.012 Kohler CG, 2004, PSYCHIAT RES, V128, P235, DOI 10.1016/j.psychres.2004.07.003 Kohls G, 2011, J AUTISM DEV DISORD, V41, P1523, DOI 10.1007/s10803-011-1177-1 Kohn N, 2011, NEUROPSYCHOLOGIA, V49, P888, DOI 10.1016/j.neuropsychologia.2011.02.010 Kopp S, 2010, J ATTEN DISORD, V14, P167, DOI 10.1177/1087054709332458 Kopp S., 1992, EUROPEAN CHILD ADOLE, V1, P89 Kopp S, 2010, RES DEV DISABIL, V31, P350, DOI 10.1016/j.ridd.2009.09.017 Lai M., 2011, PLOS ONE, V6 Lai M.-C., 2012, PLOS ONE, V7 Lamm C., 2007, J COGNITIVE NEUROSCI, V19, P1 Lee Hongjoo J, 2010, Learn Mem, V17, P531, DOI 10.1101/lm.1889510 Lemon JM, 2011, J AUTISM DEV DISORD, V41, P352, DOI 10.1007/s10803-010-1039-2 Levant RF, 2009, PSYCHOL MEN MASCULIN, V10, P190, DOI 10.1037/a0015652 Lin A, 2012, SOC COGN AFFECT NEUR, V7, P274, DOI 10.1093/scan/nsr006 Lombardo M. V., 2012, IMFAR 2012 MAY 17 19 Lord C., 1999, AUTISM DIAGNOSTIC OB Masten CL, 2011, NEUROIMAGE, V55, P381, DOI 10.1016/j.neuroimage.2010.11.060 Narzisi A., J AUTISM DE IN PRESS Nordahl CW, 2011, P NATL ACAD SCI USA, V108, P20195, DOI 10.1073/pnas.1107560108 Nyden A, 2000, EUR CHILD ADOLES PSY, V9, P180 OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4 Phillips ML, 2003, BIOL PSYCHIAT, V54, P504, DOI 10.1016/S0006-3223(03)00168-9 Regenbogen C, 2012, NEUROIMAGE, V60, P2346, DOI 10.1016/j.neuroimage.2012.02.043 Regenbogen C, 2012, COGNITION EMOTION, V26, P995, DOI 10.1080/02699931.2011.631296 REITAN R. M., 1958, PERCEPT MOT SKILLS, V8, P271 Schmidt K-H, 1992, WORTSCHATZTEST WST Schneider D, 2012, PSYCHIAT RES, V200, P294, DOI 10.1016/j.psychres.2012.03.054 Schneider K., SOCIAL COGN IN PRESS Schulte-Ruther M., 2010, SOC NEUROSCI, V13, P1 Schulte-Ruther M, 2008, NEUROIMAGE, V42, P393, DOI 10.1016/j.neuroimage.2008.04.180 Schulte-Ruther M, 2007, J COGNITIVE NEUROSCI, V19, P1354, DOI 10.1162/jocn.2007.19.8.1354 Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010 Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007 Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170 Shamay-Tsoory Simone G, 2011, Neuroscientist, V17, P18, DOI 10.1177/1073858410379268 Sparks BF, 2002, NEUROLOGY, V59, P184 Stocke V., 2009, ZUSAMMENSTELLUNG SOZ Tepest R, 2010, PSYCHIAT RES-NEUROIM, V183, P38, DOI 10.1016/j.pscychresns.2010.04.007 Vollm BA, 2006, NEUROIMAGE, V29, P90, DOI 10.1016/j.neuroimage.2005.07.022 von Aster M., 2006, WECHSLER INTELLIGENZ Ward B. D., 2000, SIMULTANEOUS INFEREN Whittle S, 2011, BIOL PSYCHOL, V87, P319, DOI 10.1016/j.biopsycho.2011.05.003 WING L, 1976, PSYCHOL MED, V6, P89 Wittchen HU, 1997, STRUKTURIERTES KLIN Zahavi D, 2010, AUTISM, V14, P547, DOI 10.1177/1362361310370040 NR 87 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 506 EP 521 DI 10.1002/aur.1310 PG 16 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900005 PM 23868876 ER PT J AU Stewart, HJ McIntosh, RD Williams, JHG AF Stewart, Hannah J. McIntosh, Rob D. Williams, Justin H. G. TI A Specific Deficit of Imitation in Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE social cognition; clinical psychology; cognitive neuroscience; developmental psychology; psychopathology ID DEVELOPMENTAL DISORDER; MIRROR NEURONS; MOVEMENT; ASPERGER; GESTURES; CHILDREN; BRAIN; SELF AB Imitation is a potentially crucial aspect of social cognitive development. Although deficits in imitation ability have been widely demonstrated in autism spectrum disorder (ASD), the specificity and significance of the findings is unclear, due largely to methodological limitations. We developed a novel assessment of imitation ability, using objective movement parameters (path length and action duration) derived from a touch-sensitive tablet laptop during drawing actions on an identical tablet. By direct comparison of the kinematics of a model's actions with those of the participant who observed them, measures of imitation accuracy were obtained. By replaying the end-point of the movement as a spot on the screen, imitation accuracy was compared against a ghost control condition, with no human actor but only the end-point of the movement seen [object movement reenactment (OMR)]. Hence, demands of the control task were closely matched to the experimental task with respect to motor, memory, and attentional abilities. Adolescents with ASD showed poorer accuracy for copying object size and action duration on both the imitation and OMR tasks, but were significantly more impaired for imitation of object size. Our results provide evidence that some of the imitation deficit in ASD is specific to a self-other mapping problem, and cannot be explained by general factors such as memory, spatial reasoning, motor control, or attention, nor related to the social demands of the testing situation. Autism Res 2013, 6: 522-530. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Stewart, Hannah J.] MRC Inst Hearing Res, Nottingham, England. [McIntosh, Rob D.] Univ Edinburgh, Edinburgh, Midlothian, Scotland. [Williams, Justin H. G.] Univ Aberdeen, Sch Med, Royal Cornhill Hosp, Clin Res Ctr, Aberdeen AB25 2ZH, Scotland. RP Williams, JHG (reprint author), Univ Aberdeen, Sch Med, Royal Cornhill Hosp, Clin Res Ctr, Cornhill Rd, Aberdeen AB25 2ZH, Scotland. EM justin.williams@abdn.ac.uk FU Northwood Trust FX JHGW is funded by the Northwood Trust. We are very grateful to Maria Parker and the MICAS base at Dyce Academy, the children and parents who volunteered their participation in this study, James Cusack for help with recruitment, and to Louisa Miller and Lorcan Kenny for excellent help with stimulus design and creation. CR Avikainen S, 2003, CURR BIOL, V13, P339, DOI 10.1016/S0960-9822(03)00087-3 Bekkering H, 2000, Q J EXP PSYCHOL-A, V53, P153, DOI 10.1080/027249800390718 Braadbaart Lieke, 2012, Front Integr Neurosci, V6, P91, DOI 10.3389/fnint.2012.00091 Brass M, 2005, TRENDS COGN SCI, V9, P489, DOI 10.1016/j.tics.2005.08.007 Charman T., 2006, IMITATION SOCIAL MIN, P96 Charman T, 2003, INT J LANG COMM DIS, V38, P265, DOI 10.1080/136820310000104830 Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 Constantino JN, 2005, SOCIAL RESPONSIVENES Culmer PR, 2009, J NEUROSCI METH, V184, P184, DOI 10.1016/j.jneumeth.2009.07.025 Custance D, 1999, J COMP PSYCHOL, V113, P13, DOI 10.1037/0735-7036.113.1.13 Dawson G, 2002, DEV PSYCHOPATHOL, V14, P581, DOI 10.1017/S0954579402003103 Decety J, 2011, EMOT REV, V3, P92, DOI 10.1177/1754073910374662 Decety J, 2003, TRENDS COGN SCI, V7, P527, DOI 10.1016/j.tics.2003.10.004 Fabbri-Destro M, 2009, EXP BRAIN RES, V192, P521, DOI 10.1007/s00221-008-1578-3 Frith U, 1991, AUTISM ASPERGER SYND GILLBERG IC, 1989, J CHILD PSYCHOL PSYC, V30, P631, DOI 10.1111/j.1469-7610.1989.tb00275.x Green D, 2002, J CHILD PSYCHOL PSYC, V43, P655, DOI 10.1111/1469-7610.00054 Hepburn S. L., 2006, IMITATION SOCIAL MIN, P431 HEYES CM, 1994, BEHAV PROCESS, V32, P173, DOI 10.1016/0376-6357(94)90074-4 Hobson RP, 1999, J CHILD PSYCHOL PSYC, V40, P649, DOI 10.1111/1469-7610.00481 Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024 Kanner L, 1943, NERV CHILD, V2, P217 Keysers C, 2004, TRENDS COGN SCI, V8, P501, DOI 10.1016/j.tics.2004.09.005 Mostofsky SH, 2006, J INT NEUROPSYCH SOC, V12, P314, DOI 10.1017/S1355617706060437 Mundy P, 2001, INT REV RES MENT RET, V23, P139 Perra O, 2008, RES AUTISM SPECT DIS, V2, P456, DOI 10.1016/j.rasd.2007.09.007 POULTON EC, 1979, PSYCHOL BULL, V86, P777, DOI 10.1037//0033-2909.86.4.777 Rogers S. J., 1991, DEV PSYCHOPATHOL, V3, P137, DOI DOI 10.1017/S0954579400000043 Rogers S. J., 2006, IMITATION SOCIAL MIN, P431 Rogers S. J., 2006, IMITATION SOCIAL MIN Rogers SJ, 1996, CHILD DEV, V67, P2060, DOI 10.2307/1131609 Rumiatil RI, 2005, J COGNITIVE NEUROSCI, V17, P1420, DOI 10.1162/0898929054985374 Rutter M., 2000, AUTISM DIAGNOSTIC IN Smith I. M., 1998, GESTURE IMITATION AU Smith I. M., 2006, IMITATION SOCIAL MIN, P431 SMITH IM, 1994, PSYCHOL BULL, V116, P259, DOI 10.1037/0033-2909.116.2.259 Smith IM, 2007, COGN NEUROPSYCHOL, V24, P679, DOI 10.1080/02643290701669703 Southgate V, 2008, TRENDS COGN SCI, V12, P225, DOI 10.1016/j.tics.2008.03.005 Subiaul F, 2010, BEHAV PROCESS, V83, P222, DOI 10.1016/j.beproc.2009.12.002 Tessari A, 2004, J EXP PSYCHOL HUMAN, V30, P1107, DOI 10.1037/0096-1523.30.6.1107 Wechsler D, 1999, WECHSLER ABBREVIATED Wild KS, 2010, EXP BRAIN RES, V204, P353, DOI 10.1007/s00221-009-2034-8 Wild KS, 2012, J AUTISM DEV DISORD, V42, P1739, DOI 10.1007/s10803-011-1417-4 Williams J. H. G., J COGNITION DEV, DOI 10.1080/15248372.2013.771265 Williams JHG, 2008, AUTISM RES, V1, P73, DOI 10.1002/aur.15 Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8 Wilson BN, 2009, PHYS OCCUPATIONAL TH, V29, P184 NR 48 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 522 EP 530 DI 10.1002/aur.1312 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900006 PM 24124055 ER PT J AU Manning, C Charman, T Pellicano, E AF Manning, Catherine Charman, Tony Pellicano, Elizabeth TI Processing Slow and Fast Motion in Children With Autism Spectrum Conditions SO AUTISM RESEARCH LA English DT Article DE autism; speed discrimination; motion coherence; visual motion processing ID VISUAL-MOTION; GLOBAL-MOTION; CONTRAST SENSITIVITY; SPEED DISCRIMINATION; BIOLOGICAL MOTION; PERCEPTION; DISORDERS; INFORMATION; COHERENCE; MODEL AB Consistent with the dorsal stream hypothesis, difficulties processing dynamic information have previously been reported in individuals with autism spectrum conditions (ASC). However, no research has systematically compared motion processing abilities for slow and fast speeds. Here, we measured speed discrimination thresholds and motion coherence thresholds in slow (1.5deg/sec) and fast (6deg/sec) speed conditions in children with an ASC aged 7 to 14 years, and age- and ability-matched typically developing children. Unexpectedly, children with ASC were as sensitive as typically developing children to differences in speed at both slow and fast reference speeds. Yet, elevated motion coherence thresholds were found in children with ASC, but in the slow stimulus speed condition only. Rather than having pervasive difficulties in motion processing, as predicted by the dorsal stream hypothesis, these results suggest that children with ASC have a selective difficulty in extracting coherent motion information specifically at slow speeds. Understanding the effects of stimulus parameters such as stimulus speed will be important for resolving discrepancies between previous studies examining motion coherence thresholds in ASC and also for refining theoretical models of altered autistic perception. Autism Res 2013, 6: 531-541. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Manning, Catherine; Pellicano, Elizabeth] Univ London, Inst Educ, Dept Psychol & Human Dev, CRAE, London WC1N 1AZ, England. [Charman, Tony] Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England. [Pellicano, Elizabeth] Univ Western Australia, Sch Psychol, Perth, WA 6009, Australia. RP Manning, C (reprint author), Inst Educ, Dept Psychol & Human Dev, CRAE, 55-59 Gordon Sq, London WC1H 0NU, England. EM c.manning@ioe.ac.uk RI Charman, Tony/A-2085-2014 OI Charman, Tony/0000-0003-1993-6549 FU Economic and Social Research Council (ESRC); Clothworkers' Foundation; Pears Foundation FX Many thanks to David Aagten-Murphy, David Burr, and Marco Cicchini for assistance with programming and experimental design and to the schools, participants, and parents who generously took part in this research. C. M. was supported by an Economic and Social Research Council (ESRC) PhD studentship. Research at CRAE is supported by The Clothworkers' Foundation and Pears Foundation. CR Adams RJ, 2002, VISION RES, V42, P1205, DOI 10.1016/S0042-6989(02)00038-X Ahmed IJ, 2005, VISION RES, V45, P2129, DOI 10.1016/j.visres.2005.01.036 Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003 Annaz D, 2010, DEVELOPMENTAL SCI, V13, P826, DOI 10.1111/j.1467-7687.2009.00939.x Antal A, 2004, J COGNITIVE NEUROSCI, V16, P521, DOI 10.1162/089892904323057263 Ascher D, 2000, VISION RES, V40, P3427, DOI 10.1016/S0042-6989(00)00176-0 Atkinson J, 1997, NEUROREPORT, V8, P1919, DOI 10.1097/00001756-199705260-00025 Bertone A, 2003, J COGNITIVE NEUROSCI, V15, P218, DOI 10.1162/089892903321208150 Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561 Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434 Braddick O, 2003, NEUROPSYCHOLOGIA, V41, P1769, DOI 10.1016/S0028-3932(03)00178-7 BRADLEY A, 1982, VISION RES, V22, P953, DOI 10.1016/0042-6989(82)90031-1 Brainard DH, 1997, SPATIAL VISION, V10, P433, DOI 10.1163/156856897X00357 BRITTEN KH, 1992, J NEUROSCI, V12, P4745 Burr D, 2011, VISION RES, V51, P1431, DOI 10.1016/j.visres.2011.02.008 Burr DC, 1998, VISION RES, V38, P3681, DOI 10.1016/S0042-6989(98)00056-X Chen Y, 2012, NEUROPSYCHOLOGIA, V50, P733, DOI 10.1016/j.neuropsychologia.2012.01.007 Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x Dakin SC, 2005, VISION RES, V45, P3027, DOI 10.1016/j.visres.2005.07.037 Davis RAO, 2006, J AUTISM DEV DISORD, V36, P199, DOI 10.1007/s10803-005-0055-0 de Jonge MV, 2007, NEUROPSYCHOLOGY, V21, P65, DOI 10.1037/0894-4105.21.1.65 Del Viva MM, 2006, VISION RES, V46, P1242, DOI 10.1016/j.visres.2005.10.018 Edwards M, 1998, VISION RES, V38, P1573, DOI 10.1016/S0042-6989(97)00353-2 Efron B., 1993, INTRO BOOTSTRAP Ellemberg D, 2004, VISION RES, V44, P2403, DOI 10.1016/j.visres.2004.05.006 Gepner B, 2009, NEUROSCI BIOBEHAV R, V33, P1227, DOI 10.1016/j.neubiorev.2009.06.006 Gepner B, 2001, J AUTISM DEV DISORD, V31, P37, DOI 10.1023/A:1005609629218 Gepner B, 2005, CAH PSYCHOL COGN, V23, P104 Gepner B, 2010, PSN-PSYCHIATR SCI HU, V8, P67, DOI 10.1007/s11836-010-0126-y Grandin T., 1995, THINKING PICTURES OT Greenaway R, 2013, NEUROPSYCHOLOGIA, V51, P592, DOI 10.1016/j.neuropsychologia.2013.01.005 Greffou S, 2012, J AUTISM DEV DISORD, V42, P961, DOI 10.1007/s10803-011-1326-6 Hadad BS, 2011, DEVELOPMENTAL SCI, V14, P1330, DOI 10.1111/j.1467-7687.2011.01078.x Hayward J, 2011, VISION RES, V51, P2216, DOI 10.1016/j.visres.2011.08.023 Huk AC, 2000, J NEUROPHYSIOL, V83, P3525 Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Jones CRG, 2011, AUTISM RES, V4, P347, DOI 10.1002/aur.209 Kemner C, 2008, J AUTISM DEV DISORD, V38, P553, DOI 10.1007/s10803-007-0406-0 Kleiner M., 2007, PERCEPTION S Koldewyn K, 2013, J AUTISM DEV DISORD, V43, P1394, DOI 10.1007/s10803-012-1694-6 Liu J, 2003, J NEUROPHYSIOL, V89, P246, DOI 10.1152/jn.00097.2002 Liu J, 2005, J NEUROSCI, V25, P711, DOI 10.1523/JNEUROSCI.4034-04.2005 Lord C., 1999, AUTISM DIAGNOSTIC OB LOVAAS OI, 1971, J ABNORM PSYCHOL, V77, P211, DOI 10.1037/h0031015 Manning C, 2012, VISION RES, V70, P27, DOI 10.1016/j.visres.2012.08.004 Matthews N, 2001, EXP BRAIN RES, V140, P397, DOI 10.1007/s002210100837 Mestre D., 2002, REV TIPA, V21, P192 Milne E, 2002, J CHILD PSYCHOL PSYC, V43, P255, DOI 10.1111/1469-7610.00018 Milner A. D., 1995, VISUAL BRAIN ACTION MISHKIN M, 1983, TRENDS NEUROSCI, V6, P414, DOI 10.1016/0166-2236(83)90190-X Narasimhan S, 2012, VISION RES, V62, P102, DOI 10.1016/j.visres.2012.02.016 O'Riordan M. A., 2001, SUPERIOR VISUAL SEAR Pelli DG, 1997, SPATIAL VISION, V10, P437, DOI 10.1163/156856897X00366 Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003 Perrone JA, 2002, VISION RES, V42, P1035, DOI 10.1016/S0042-6989(02)00029-9 Robertson C. E., 2012, PLOS ONE, V7, P1 Ronconi L, 2013, CORTEX, V49, P1025, DOI 10.1016/j.cortex.2012.03.005 Ronconi L, 2012, PLOS ONE, V7, P1 Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Rutter M., 2003, SOCIAL COMMUNICATION Sanchez-Marin FJ, 2008, J AUTISM DEV DISORD, V38, P1270, DOI 10.1007/s10803-007-0507-9 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005 Spencer J, 2000, NEUROREPORT, V11, P2765, DOI 10.1097/00001756-200008210-00031 Tabachnick B., 2007, USING MULTIVARIATE S, V5th Thompson P, 2006, VISION RES, V46, P782, DOI 10.1016/j.visres.2005.08.005 TREUTWEIN B, 1995, VISION RES, V35, P2503, DOI 10.1016/0042-6989(95)00016-X WATSON AB, 1979, VISION RES, V19, P515, DOI 10.1016/0042-6989(79)90136-6 WATSON AB, 1983, PERCEPT PSYCHOPHYS, V33, P113, DOI 10.3758/BF03202828 Wechsler D, 1999, WECHSLER ABBREVIATED WHO, 1993, ICD 10 CLASS MENT BE Williams D., 1999, NOBODY NOWHERE EXTRA NR 73 TC 5 Z9 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 531 EP 541 DI 10.1002/aur.1309 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900007 PM 23847052 ER PT J AU Coskun, MA Loveland, KA Pearson, DA Papanicolaou, AC Sheth, BR AF Coskun, Mehmet A. Loveland, Katherine A. Pearson, Deborah A. Papanicolaou, Andrew C. Sheth, Bhavin R. TI Interaction of Finger Representations in the Cortex of Individuals with Autism: A Functional Window into Cortical Inhibition SO AUTISM RESEARCH LA English DT Article DE evoked potentials; homeostasis; somatosensory cortex; cortical interaction; finger representation; source modeling; tactile ID DEVELOPMENTAL NEUROBIOLOGY; EVOKED POTENTIALS; SPECTRUM DISORDER; CONNECTIVITY; RESPONSES; CHILDREN; STIMULI; DIGITS; ADULTS; MODEL AB An established neural biomarker of autism spectrum disorder (ASD) has the potential to provide novel biological and pharmacological targets for treatment. Lower level of inhibition in brain circuits is a leading biomarker candidate. A physiological investigation of the functional levels of inhibition in the cortex of individuals with autism can provide a strong test of the hypothesis. The amplitude of cortical response to the stimulation of adjacent fingers is controlled by the level of cortical inhibition and provides just such a test. Using magnetoencephalography, we recorded the response of the somatosensory cortex to the passive tactile stimulation of the thumb (D1), and index finger (D2), and to the simultaneous stimulation of both fingers combined (D1,D2) of the dominant (right) hand of young subjects with and without autism. For each participant, we measured the response to the stimulation of both fingers combined (D1,D2) relative to the post hoc sum of the responses to the stimulation of each finger alone (D1+D2) in multiple different ways and linearly regressed the ASD and neurotypical (NT) groups' responses. The resulting slopes were then compared: Smaller slope values imply attenuated response to paired finger stimulation, and enhanced levels of inhibition. The short-latency M40 and mid-latency M80 response slopes of the group with autism obtained in different ways were either significantly smaller, or statistically indistinguishable from NT. The result does not support reduced inhibition in the somatosensory cortex of individuals with autism, contrary to the seminal hypothesis of reduced inhibition. Implications are discussed including refinements of current theory. Autism Res 2013, 6: 542-549. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Coskun, Mehmet A.; Sheth, Bhavin R.] Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA. [Loveland, Katherine A.; Pearson, Deborah A.] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA. [Papanicolaou, Andrew C.] Univ Texas Hlth Sci Ctr Houston, Dept Pediat, Houston, TX 77030 USA. [Sheth, Bhavin R.] Univ Houston, Ctr NeuroEngn & Cognit Syst, Houston, TX 77204 USA. RP Sheth, BR (reprint author), Univ Houston, N308, Houston, TX 77204 USA. EM brsheth@uh.edu FU National Alliance for Autism Research-Autism Speaks; University of Houston; NIH [P01 HD035471, R01 MH072263] FX The authors report no competing interests. The research was supported by a grant from the National Alliance for Autism Research-Autism Speaks (BRS). MAC was supported in part by a Presidential fellowship from the University of Houston. KAL and DAP were supported by the NIH: P01 HD035471 (KAL) and R01 MH072263 (DAP). CR Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552 Coskun MA, 2013, AUTISM RES, V6, P190, DOI 10.1002/aur.1276 Courchesne E, 2001, NEUROLOGY, V57, P245 DiCicco-Bloom E, 2006, J NEUROSCI, V26, P6897, DOI 10.1523/JNEUROSCI.1712-06.2006 Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0 FLEMING PJ, 1986, COMMUN ACM, V29, P218, DOI 10.1145/5666.5673 Friedman RM, 2008, J NEUROPHYSIOL, V100, P3185, DOI 10.1152/jn.90278.2008 GANDEVIA SC, 1983, EXP BRAIN RES, V50, P415 Gibson JR, 2008, J NEUROPHYSIOL, V100, P2615, DOI 10.1152/jn.90752.2008 Greek KA, 2003, EXP BRAIN RES, V151, P364, DOI 10.1007/s00221-003-1493-6 Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110 HILLYARD SA, 1971, SCIENCE, V172, P1357, DOI 10.1126/science.172.3990.1357 HSIEH CL, 1995, EVOKED POTENTIAL, V96, P135 Hussman JP, 2001, J AUTISM DEV DISORD, V31, P247, DOI 10.1023/A:1010715619091 Keita L, 2010, AUTISM RES, V3, P333, DOI 10.1002/aur.164 Kemner C, 2002, J CLIN PSYCHIAT, V63, P214 Lord C., 1999, AUTISM DIAGNOSTIC OB Magnee MJCM, 2009, NEUROPSYCHOLOGIA, V47, P1728, DOI 10.1016/j.neuropsychologia.2009.02.012 McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150 OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4 Orekhova EV, 2008, NEUROSCI LETT, V434, P218, DOI 10.1016/j.neulet.2008.01.066 Perry W, 2007, BIOL PSYCHIAT, V61, P482, DOI 10.1016/j.biopsych.2005.09.025 Picton TW, 1988, HDB ELECTROENCEPHALO, V3, P361 Polleux F, 2004, MENT RETARD DEV D R, V10, P303, DOI 10.1002/mrdd.20044 Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Rutter M., 2003, AUTISM DIAGNOSTIC IN Tannan V, 2008, AUTISM RES, V1, P223, DOI 10.1002/aur.34 Tommerdahl M, 2007, BRAIN RES, V1154, P116, DOI 10.1016/j.brainres.2007.04.032 Tommerdahl M, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-19 Viswanathan D, 2010, INT J PSYCHOPHYSIOL, V78, P251, DOI 10.1016/j.ijpsycho.2010.08.006 Wechsler D, 1999, WECHSLER ABBREVIATED Zhu Z, 2009, BMC NEUROSCI, V10, DOI 10.1186/1471-2202-10-4 NR 32 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 542 EP 549 DI 10.1002/aur.1314 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900008 PM 23983203 ER PT J AU Arkush, L Smith-Collins, APR Fiorentini, C Skuse, DH AF Arkush, Leo Smith-Collins, Adam P. R. Fiorentini, Chiara Skuse, David H. TI Recognition of Face and Non-Face Stimuli in Autistic Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE autism; ASD; face expertise; face recognition memory; Warrington Recognition Memory Test ID PERVASIVE DEVELOPMENTAL DISORDERS; FUNCTIONING AUTISM; FAMILIAR FACE; CHILDREN; MEMORY; INDIVIDUALS; PATTERNS; OBJECTS; PROSOPAGNOSIA; IMPAIRMENT AB The ability to remember faces is critical for the development of social competence. From childhood to adulthood, we acquire a high level of expertise in the recognition of facial images, and neural processes become dedicated to sustaining competence. Many people with autism spectrum disorder (ASD) have poor face recognition memory; changes in hairstyle or other non-facial features in an otherwise familiar person affect their recollection skills. The observation implies that they may not use the configuration of the inner face to achieve memory competence, but bolster performance in other ways. We aimed to test this hypothesis by comparing the performance of a group of high-functioning unmedicated adolescents with ASD and a matched control group on a surprise face recognition memory task. We compared their memory for unfamiliar faces with their memory for images of houses. To evaluate the role that is played by peripheral cues in assisting recognition memory, we cropped both sets of pictures, retaining only the most salient central features. ASD adolescents had poorer recognition memory for faces than typical controls, but their recognition memory for houses was unimpaired. Cropping images of faces did not disproportionately influence their recall accuracy, relative to controls. House recognition skills (cropped and uncropped) were similar in both groups. In the ASD group only, performance on both sets of task was closely correlated, implying that memory for faces and other complex pictorial stimuli is achieved by domain-general (non-dedicated) cognitive mechanisms. Adolescents with ASD apparently do not use domain-specialized processing of inner facial cues to support face recognition memory. Autism Res 2013, 6: 550-560. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Arkush, Leo; Smith-Collins, Adam P. R.; Skuse, David H.] UCL, Inst Child Hlth, London WC1N 1EH, England. [Smith-Collins, Adam P. R.] Univ Bristol, St Michaels Hosp, Sch Clin Sci, Dept Neonatal Neurosci, Bristol, Avon, England. [Fiorentini, Chiara] Univ Geneva, Swiss Ctr Affect Sci, Geneva, Switzerland. RP Skuse, DH (reprint author), UCL, Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England. EM dskuse@ich.ucl.ac.uk FU INCORE [043318]; GEBACO [028696]; Swiss National Science Foundation (FNS) FX Grant sponsors: INCORE, grant number: 043318; GEBACO, grant number: 028696; C. F. was supported by a Swiss National Science Foundation (FNS) Fellowship for young researchers during the period of this research. CR Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Barton JJS, 2004, BRAIN, V127, P1706, DOI 10.1093/brain/awh194 Blair RJR, 2002, NEUROPSYCHOLOGIA, V40, P108, DOI 10.1016/S0028-3932(01)00069-0 BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x Boucher J, 1998, J CHILD PSYCHOL PSYC, V39, P171, DOI 10.1017/S0021963097001820 BRAVERMAN M, 1989, J AUTISM DEV DISORD, V19, P301, DOI 10.1007/BF02211848 Duchaine B, 2006, NEUROPSYCHOLOGIA, V44, P576, DOI 10.1016/j.neuropsychologia.2005.07.001 Duchaine BC, 2000, NEUROREPORT, V11, P79, DOI 10.1097/00001756-200001170-00016 Duchaine BC, 2003, NEUROPSYCHOLOGIA, V41, P713, DOI 10.1016/S0028-3932(02)00222-1 Faja S, 2009, J AUTISM DEV DISORD, V39, P532, DOI 10.1007/s10803-008-0635-x Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149 FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8 Gauthier I, 2009, VISION RES, V49, P470, DOI 10.1016/j.visres.2008.12.007 Greene DJ, 2011, NEUROIMAGE, V56, P354, DOI 10.1016/j.neuroimage.2011.02.031 Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025 Happe F, 2004, J CHILD PSYCHOL PSYC, V45, P1183, DOI 10.1111/j.1469-7610.2004.00403.x Hauck M, 1998, CHILD NEUROPSYCHOL, V4, P187, DOI 10.1076/chin.4.3.187.3174 Helle C., 2000, COMPUTATION VISION W Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724 Humphreys K, 2008, AUTISM RES, V1, P52, DOI 10.1002/aur.1 Kanwisher N, 1997, J NEUROSCI, V17, P4302 Karmiloff-Smith A, 2009, DEV PSYCHOL, V45, P56, DOI 10.1037/a0014506 Kendrick KM, 2001, NATURE, V414, P165, DOI 10.1038/35102669 Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4 LEVINE SC, 1988, BRAIN COGNITION, V8, P303, DOI 10.1016/0278-2626(88)90057-7 Maurer D, 2002, TRENDS COGN SCI, V6, P255, DOI 10.1016/S1364-6613(02)01903-4 McKone E, 2007, TRENDS COGN SCI, V11, P8, DOI 10.1016/j.tics.2006.11.002 McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x McPartland JC, 2011, J AUTISM DEV DISORD, V41, P148, DOI 10.1007/s10803-010-1033-8 Nunn JA, 2001, NEUROCASE, V7, P15, DOI 10.1093/neucas/7.1.15 O'Hearn K, 2010, NEUROPSYCHOLOGIA, V48, P3955, DOI 10.1016/j.neuropsychologia.2010.08.024 Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239 Pellicano E, 2007, CURR BIOL, V17, P1508, DOI 10.1016/j.cub.2007.07.065 Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369 Pierce K, 2004, BRAIN, V127, P2703, DOI 10.1093/brain/awh289 Rondan C, 2003, CHILD NEUROPSYCHOL, V9, P289, DOI 10.1076/chin.9.4.289.23516 RUTTER M, 1987, J AUTISM DEV DISORD, V17, P159, DOI 10.1007/BF01495054 Scherf KS, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00026 Schultz RT, 2003, PHILOS T ROY SOC B, V358, P415, DOI 10.1098/rstb.2002.1208 Skuse DH, 2009, J AM ACAD CHILD PSY, V48, P128, DOI 10.1097/CHI.0b013e31819176b8 TEUNISSE JP, 1994, INT J NEUROSCI, V77, P1 Tsao DY, 2006, TRENDS COGN SCI, V10, P391, DOI 10.1016/j.tics.2006.07.009 Wallace S, 2008, AUTISM RES, V1, P43, DOI 10.1002/aur.7 Warrington E., 1984, RECOGNITION MEMORY T Wechsler D, 1999, WECHSLER ABBREVIATED Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008 Wilson R, 2007, J AUTISM DEV DISORD, V37, P314, DOI 10.1007/s10803-006-0169-z Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56 NR 50 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 550 EP 560 DI 10.1002/aur.1318 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900009 PM 23894016 ER PT J AU Lo, YC Chou, TL Fan, LY Gau, SSF Chiu, YN Tseng, WYI AF Lo, Yu-Chun Chou, Tai-Li Fan, Li-Ying Gau, Susan Shur-Fen Chiu, Yen-Nan Tseng, Wen-Yih Isaac TI Altered Structure-Function Relations of Semantic Processing in Youths with High-Functioning Autism: A Combined Diffusion and Functional MRI Study SO AUTISM RESEARCH LA English DT Article DE autism; dual stream model; diffusion spectrum imaging; functional MRI; tractography ID SPECTRUM DISORDERS; EARLY LANGUAGE; PSYCHOMETRIC PROPERTIES; PREFRONTAL CORTEX; CHINESE VERSION; WHITE-MATTER; CHILDREN; ADOLESCENTS; ACTIVATION; SYNCHRONIZATION AB Deficits in language and communication are among the core symptoms of autism, a common neurodevelopmental disorder with long-term impairment. Despite the striking nature of the autistic language impairment, knowledge about its corresponding alterations in the brain is still evolving. We hypothesized that the dual stream language network is altered in autism, and that this alteration could be revealed by changes in the relationships between microstructural integrity and functional activation. The study recruited 20 right-handed male youths with autism and 20 carefully matched individually, typically developing (TD) youths. Microstructural integrity of the left dorsal and left ventral pathways responsible for language processing and the functional activation of the connected brain regions were investigated by using diffusion spectrum imaging and functional magnetic resonance imaging of a semantic task, respectively. Youths with autism had significantly poorer language function, and lower functional activation in left dorsal and left ventral regions of the language network, compared with TD youths. The TD group showed a significant correlation of the functional activation of the left dorsal region with microstructural integrity of the left ventral pathway, whereas the autism group showed a significant correlation of the functional activation of the left ventral region with microstructural integrity of the left dorsal pathway, and moreover verbal comprehension index was correlated with microstructural integrity of the left ventral pathway. These altered structure-function relationships in autism suggest possible involvement of the dual pathways in supporting deficient semantic processing. Autism Res 2013, 6: 561-570. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Lo, Yu-Chun; Gau, Susan Shur-Fen] Natl Taiwan Univ, Coll Med, Dept Psychiat, Taipei 10051, Taiwan. [Lo, Yu-Chun; Tseng, Wen-Yih Isaac] Natl Taiwan Univ, Coll Med, Ctr Optoelect Med, Taipei 10051, Taiwan. [Chou, Tai-Li; Gau, Susan Shur-Fen; Tseng, Wen-Yih Isaac] Natl Taiwan Univ, Grad Inst Brain & Mind Sci, Taipei 10051, Taiwan. [Chou, Tai-Li; Fan, Li-Ying; Gau, Susan Shur-Fen] Natl Taiwan Univ, Dept Psychol, Taipei 10051, Taiwan. [Chou, Tai-Li; Gau, Susan Shur-Fen; Tseng, Wen-Yih Isaac] Natl Taiwan Univ, Neurobiol & Cognit Sci Ctr, Taipei 10051, Taiwan. [Gau, Susan Shur-Fen; Chiu, Yen-Nan] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei 10002, Taiwan. [Tseng, Wen-Yih Isaac] Natl Taiwan Univ Hosp, Dept Med Imaging, Taipei 10002, Taiwan. RP Tseng, WYI (reprint author), Natl Taiwan Univ, Coll Med, Ctr Optoelect Biomed, 1,Sec 1,Jen Ai Rd, Taipei 10051, Taiwan. EM gaushufe@ntu.edu.tw; wytseng@ntu.edu.tw FU National Science Council, Taiwan [NSC99-2321-B-002-037, NSC100-2321-B-002-015, NSC97-3112-B-002-009, NSC98-3112-B-002-004, NSC99-2627-B-002-015, NSC99-2627-B-002-016, NSC100-2627-B-002-013]; National Taiwan University Hospital [NTUH101-S1910]; Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan FX This work was supported by the National Science Council, Taiwan (NSC99-2321-B-002-037, NSC100-2321-B-002-015 to Dr. W-Y. Tseng; NSC97-3112-B-002-009, NSC98-3112-B-002-004, NSC99-2627-B-002-015 to Dr. S. S-F. Gau; and NSC99-2627-B-002-016, NSC100-2627-B-002-013 to Dr. T-L. Chou) and National Taiwan University Hospital (NTUH101-S1910), and partly by the Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan. We thank all of the participants for their involvement in this study. CR Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022 Boddaert N, 2004, AM J PSYCHIAT, V161, P2117, DOI 10.1176/appi.ajp.161.11.2117 Brose N, 2010, BIOCHEM SOC T, V38, P443, DOI 10.1042/BST0380443 Burock MA, 1998, NEUROREPORT, V9, P3735, DOI 10.1097/00001756-199811160-00030 Caronna EB, 2008, ARCH DIS CHILD, V93, P518, DOI 10.1136/adc.2006.115337 Chiang W.Y., 2007, P 16 TRIENN C INT SO Chien YL, 2011, PROG NEURO-PSYCHOPH, V35, P1512, DOI 10.1016/j.pnpbp.2011.04.010 Chou TL, 2009, EXP BRAIN RES, V198, P465, DOI 10.1007/s00221-009-1942-y Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018 Eyler LT, 2012, BRAIN, V135, P949, DOI 10.1093/brain/awr364 Flagg EJ, 2005, NEUROSCI LETT, V386, P82, DOI 10.1016/j.neulet.2005.05.037 Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083 Fritzsche KH, 2010, NEUROIMAGE, V51, P242, DOI 10.1016/j.neuroimage.2010.02.007 Gaffrey MS, 2007, NEUROPSYCHOLOGIA, V45, P1672, DOI 10.1016/j.neuropsychologia.2007.01.008 Gau SSF, 2005, AM J PSYCHIAT, V162, P1344, DOI 10.1176/appi.ajp.162.7.1344 Gau SSF, 2010, PSYCHIAT CLIN NEUROS, V64, P70, DOI 10.1111/j.1440-1819.2009.02034.x Gau SSF, 2013, RES AUTISM SPECT DIS, V7, P349, DOI 10.1016/j.rasd.2012.10.004 Gau SSF, 2011, RES AUTISM SPECT DIS, V5, P809, DOI 10.1016/j.rasd.2010.09.010 Glasser MF, 2008, CEREB CORTEX, V18, P2471, DOI 10.1093/cercor/bhn011 Goldberg WA, 2008, J AUTISM DEV DISORD, V38, P1136, DOI 10.1007/s10803-007-0498-6 Gorczewski K, 2009, MAGN RESON MATER PHY, V22, P63, DOI 10.1007/s10334-008-0144-0 Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069 Harris GJ, 2006, BRAIN COGNITION, V61, P54, DOI 10.1016/j.bandc.2005.12.015 Hsiao MN, 2013, RES DEV DISABIL, V34, P254, DOI 10.1016/j.ridd.2012.08.001 Hue C. W., 2005, MONOGRAPHS CHINESE J Jarvinen-Pasley A, 2008, J AUTISM DEV DISORD, V38, P1328, DOI 10.1007/s10803-007-0520-z Jones TB, 2010, NEUROIMAGE, V49, P401, DOI 10.1016/j.neuroimage.2009.07.051 Josephs O, 1999, PHILOS T R SOC B, V354, P1215, DOI 10.1098/rstb.1999.0475 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kamio Y, 2007, J AUTISM DEV DISORD, V37, P1116, DOI 10.1007/s10803-006-0254-3 Knaus TA, 2008, J INT NEUROPSYCH SOC, V14, P967, DOI 10.1017/S1355617708081216 Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042 Lo YC, 2011, PSYCHIAT RES-NEUROIM, V192, P60, DOI 10.1016/j.pscychresns.2010.09.008 McCleery JP, 2010, J CHILD PSYCHOL PSYC, V51, P277, DOI 10.1111/j.1469-7610.2009.02157.x Minagawa-Kawai Y, 2009, NEUROREPORT, V20, P1219, DOI 10.1097/WNR.0b013e32832fa65f Mitchell S, 2006, J DEV BEHAV PEDIATR, V27, pS69, DOI 10.1097/00004703-200604002-00004 Mori S., 2005, MRI ATLAS HUMAN WHIT Peca J, 2012, CURR OPIN NEUROBIOL, V22, P866, DOI 10.1016/j.conb.2012.02.015 Poldrack RA, 1999, NEUROIMAGE, V10, P15, DOI 10.1006/nimg.1999.0441 Rapin I, 2003, BRAIN DEV-JPN, V25, P166, DOI 10.1016/S0387-7604(02)00191-2 Rauschecker Josef P, 2012, Front Evol Neurosci, V4, P7, DOI 10.3389/fnevo.2012.00007 Rauschecker JP, 2009, NAT NEUROSCI, V12, P718, DOI 10.1038/nn.2331 Rauschecker JP, 2011, HEARING RES, V271, P16, DOI 10.1016/j.heares.2010.09.001 Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198 Reese TG, 2003, MAGNET RESON MED, V49, P177, DOI 10.1002/mrm.10308 Rutter M., 2003, AUTISM DIAGNOSTIC IN Sahyoun CP, 2010, NEUROPSYCHOLOGIA, V48, P86, DOI 10.1016/j.neuropsychologia.2009.08.013 Saur D, 2008, P NATL ACAD SCI USA, V105, P18035, DOI 10.1073/pnas.0805234105 Stefanatos GA, 2011, NEUROPSYCHOL REV, V21, P252, DOI 10.1007/s11065-011-9178-6 Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099 Toichi M, 2001, J AUTISM DEV DISORD, V31, P483, DOI 10.1023/A:1012216925216 Tuch DS, 2004, MAGNET RESON MED, V52, P1358, DOI 10.1002/mrm.20279 Wagner AD, 2001, NEURON, V31, P329, DOI 10.1016/S0896-6273(01)00359-2 Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1 Yeh FC, 2011, NEUROIMAGE, V55, P1054, DOI 10.1016/j.neuroimage.2010.11.087 NR 56 TC 3 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 561 EP 570 DI 10.1002/aur.1315 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900010 PM 23853172 ER PT J AU Oblak, A Gibbs, TT Blatt, GJ AF Oblak, Adrian Gibbs, Terrell T. Blatt, Gene J. TI Reduced Serotonin Receptor Subtypes in a Limbic and a Neocortical Region in Autism SO AUTISM RESEARCH LA English DT Article DE autism; serotonin; 5-HT1A receptors; 5-HT2A receptors; 5-HT transporters; pharmacotherapy; selective serotonin reuptake inhibitors (SSRI) ID WHOLE-BLOOD SEROTONIN; PERVASIVE DEVELOPMENTAL DISORDERS; FUSIFORM GYRUS; SPECTRUM DISORDERS; 1ST-DEGREE RELATIVES; PLATELET SEROTONIN; CINGULATE CORTEX; YOUNG-CHILDREN; BINDING; ADULTS AB Autism is a behaviorally defined, neurological disorder with symptom onset before the age of 3. Abnormalities in social-emotional behaviors are a core deficit in autism, and are characterized by impaired reciprocal-social interaction, lack of facial expressions, and the inability to recognize familiar faces. The posterior cingulate cortex (PCC) and fusiform gyrus (FG) are two regions within an extensive limbic-cortical network that contribute to social-emotional behaviors. Evidence indicates that changes in brains of individuals with autism begin prenatally. Serotonin (5-HT) is one of the earliest expressed neurotransmitters, and plays an important role in synaptogenesis, neurite outgrowth, and neuronal migration. Abnormalities in 5-HT systems have been implicated in several psychiatric disorders, including autism, as evidenced by immunology, imaging, genetics, pharmacotherapy, and neuropathology. Although information is known regarding peripheral 5-HT in autism, there is emerging evidence that 5-HT systems in the central nervous system, including various 5-HT receptor subtypes and transporters, are affected in autism. The present study demonstrated significant reductions in 5-HT1A receptor-binding density in superficial and deep layers of the PCC and FG, and in the density of 5-HT2A receptors in superficial layers of the PCC and FG. A significant reduction in the density of serotonin transporters (5-HTT) was also found in the deep layers of the FG, but normal levels were demonstrated in both layers of the PCC and superficial layers of the FG. This study provides potential substrates for decreased 5-HT modulation/innervation in the autism brain, and implicate two 5-HT receptor subtypes as potential neuromarkers for novel or existing pharmacotherapies. Autism Res 2013, 6: 571-583. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Oblak, Adrian; Blatt, Gene J.] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA. [Gibbs, Terrell T.] Boston Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02118 USA. RP Oblak, A (reprint author), Boston Univ, Sch Med, Dept Anat & Neurobiol, 700 Albany St,W-701, Boston, MA 02118 USA. EM aoblak@bu.edu FU National Institutes of Health [NIH U54 MH66398]; Nancy Lurie Marks Foundation; Hussman Foundation FX This work was supported by a Studies to Advance Autism Research and Treatment (STAART) grant from the National Institutes of Health (NIH U54 MH66398), The Nancy Lurie Marks Foundation, and The Hussman Foundation. Human tissue was obtained from the Harvard Brain Tissue Resource Center, The Autism Tissue Program (ATP), The Autism Research Foundation (TARF), and the NICHD Brain and Tissue Bank for Developmental Disorders at The University of Maryland, Baltimore. CR ABRAMSON RK, 1989, J AUTISM DEV DISORD, V19, P397, DOI 10.1007/BF02212938 ADRIEN JL, 1992, J AUTISM DEV DISORD, V22, P375, DOI 10.1007/BF01048241 ANDERSON GM, 1987, J CHILD PSYCHOL PSYC, V28, P885, DOI 10.1111/j.1469-7610.1987.tb00677.x Azmitia EC, 2011, NEUROPHARMACOLOGY, V60, P1347, DOI 10.1016/j.neuropharm.2011.02.002 Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1 BAUMAN M, 1985, NEUROLOGY, V35, P866 Blankenship K, 2010, PEDIAT HLTH, V4, P375, DOI DOI 10.2217/PHE.10.45 Brodmann K., 1909, VERGLEICHENDE LOKALI Brune CW, 2006, AM J PSYCHIAT, V163, P2148, DOI 10.1176/appi.ajp.163.12.2148 Casanova MF, 2006, NEUROSCIENTIST, V12, P435, DOI 10.1177/1073858406290375 Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552 Casanova MF, 2004, ANN NEUROL, V56, P453, DOI 10.1002/ana.20196 Chifari R, 2002, EPILEPSIA, V43, P1096, DOI 10.1046/j.1528-1157.2002.34101.x Ching HD, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009043.pub2 Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008 COOK EH, 1993, LIFE SCI, V52, P2005, DOI 10.1016/0024-3205(93)90685-V Couturier JL, 2002, J CHILD ADOL PSYCHOP, V12, P243, DOI 10.1089/104454602760386932 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Daly EM, 2012, ARCH GEN PSYCHIAT, V69, P1003, DOI 10.1001/archgenpsychiatry.2012.513 DeLong GR, 1998, DEV MED CHILD NEUROL, V40, P551 GEARY WA, 1985, BRAIN RES, V337, P99, DOI 10.1016/0006-8993(85)91613-0 GILLBERG C, 1990, J CHILD PSYCHOL PSYC, V31, P921, DOI 10.1111/j.1469-7610.1990.tb00834.x Goldberg J, 2009, J AUTISM DEV DISORD, V39, P97, DOI 10.1007/s10803-008-0604-4 Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025 Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627 HOSHINO Y, 1987, JPN J PSYCHIAT NEUR, V41, P237 Hranilovic D, 2007, J AUTISM DEV DISORD, V37, P1934, DOI 10.1007/s10803-006-0324-6 Kanwisher N, 1997, J NEUROSCI, V17, P4302 King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30 Lam KSL, 2006, RES DEV DISABIL, V27, P254, DOI 10.1016/j.ridd.2005.03.003 Leboyer M, 1999, BIOL PSYCHIAT, V45, P158, DOI 10.1016/S0006-3223(97)00532-5 LEVENTHAL BL, 1990, J AUTISM DEV DISORD, V20, P499, DOI 10.1007/BF02216055 Lopez-Figueroa AL, 2004, BIOL PSYCHIAT, V55, P225, DOI 10.1016/j.biopsych.2003.09.017 Makkonen I, 2008, DEV MED CHILD NEUROL, V50, P593, DOI 10.1111/j.1469-8749.2008.03027.x Mandell D. S., 2008, PEDIATRICS, V121, P441 McBride PA, 1998, BMC MED GENET, V37, P767 McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142 Merlet I, 2004, NEUROIMAGE, V22, P886, DOI 10.1016/j.neuroimage.2004.02.014 Meschaks A, 2005, ARCH NEUROL-CHICAGO, V62, P946, DOI 10.1001/archneur.62.6.946 Murphy DGM, 2006, AM J PSYCHIAT, V163, P934, DOI 10.1176/appi.ajp.163.5.934 Nagaraj R, 2006, J CHILD NEUROL, V21, P450, DOI 10.2310/7010.2006.00099 Nakamura K, 2010, ARCH GEN PSYCHIAT, V67, P59, DOI 10.1001/archgenpsychiatry.2009.137 Namerow LB, 2003, J DEV BEHAV PEDIATR, V24, P104 Nasr S, 2011, J NEUROSCI, V31, P13771, DOI 10.1523/JNEUROSCI.2792-11.2011 Oblak A, 2009, AUTISM RES, V2, P205, DOI 10.1002/aur.88 Oblak AL, 2011, BRAIN RES, V1380, P218, DOI 10.1016/j.brainres.2010.09.021 Oblak AL, 2011, AUTISM RES, V4, P200, DOI 10.1002/aur.188 Oblak AL, 2010, J NEUROCHEM, V114, P1414, DOI 10.1111/j.1471-4159.2010.06858.x Oswald DP, 2007, J CHILD ADOL PSYCHOP, V17, P348, DOI 10.1089/cap.2006.17303 Pagani M, 2012, J AUTISM DEV DISORD, V42, P313, DOI 10.1007/s10803-011-1240-y Palfi A, 1998, J HISTOCHEM CYTOCHEM, V46, P1141 Pandina GJ, 2006, J CHILD ADOL PSYCHOP, V16, P379, DOI 10.1089/cap.2006.16.379 PIVEN J, 1991, J AUTISM DEV DISORD, V21, P51, DOI 10.1007/BF02206997 Posey DJ, 2006, J CHILD ADOL PSYCHOP, V16, P181, DOI 10.1089/cap.2006.16.181 SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8 Shea S, 2004, PEDIATRICS, V114, P634 Simms ML, 2009, ACTA NEUROPATHOL, V118, P673, DOI 10.1007/s00401-009-0568-2 Singh VK, 1997, BIOL PSYCHIAT, V41, P753, DOI 10.1016/S0006-3223(96)00522-7 Surguladze SA, 2008, GENES BRAIN BEHAV, V7, P543, DOI 10.1111/j.1601-183X.2008.00390.x Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648 Tadori Y, 2005, EUR J PHARMACOL, V515, P10, DOI 10.1016/j.ejphar.2005.02.051 Uddin LQ, 2011, BIOL PSYCHIAT, V70, P833, DOI 10.1016/j.biopsych.2011.07.014 van Kooten IAJ, 2008, BRAIN, V131, P987, DOI 10.1093/brain/awn033 Wassink TH, 2007, ARCH GEN PSYCHIAT, V64, P709, DOI 10.1001/archpsyc.64.6.709 Weiner KS, 2010, NEUROIMAGE, V52, P1559, DOI 10.1016/j.neuroimage.2010.04.262 Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057 West Lis, 2006, Pediatr Nurs, V32, P545 NR 68 TC 5 Z9 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 571 EP 583 DI 10.1002/aur.1317 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900011 PM 23894004 ER PT J AU Joseph, L Thurm, A Farmer, C Shumway, S AF Joseph, Lisa Thurm, Audrey Farmer, Cristan Shumway, Stacy TI Repetitive Behavior and Restricted Interests in Young Children with Autism: Comparisons with Controls and Stability Over 2 Years SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; repetitive behaviors; young children; trajectory ID SPECTRUM DISORDERS; ADOS SCORES; FOLLOW-UP; AGE; TRAJECTORIES; ASSOCIATION; SEVERITY; SYMPTOMS; TODDLERS; INFANTS AB Restricted, repetitive and stereotyped patterns of behavior, interests and activities [RRBs] are among the core symptoms of autism spectrum disorders (ASD). Previous studies have indicated that RRBs differentiate ASD from other developmental disorders and from typical development. This study examined the presentation of RRBs as reported on the Repetitive Behavior Scale-Revised, a caregiver report, in children with ASD [separated into autism and Pervasive Developmental Disorder-Not Otherwise Specified groups] compared with children with nonspectrum developmental delays or typical development. We examined the role of age, cognitive functioning, sex and social communication impairment as they relate to RRBs. The stability of RRBs in children with autism was also examined over the course of 2 years. Results of the study confirmed that the amount and type of RRBs differs by diagnosis. Age, cognitive functioning, sex and social-communication impairment were not significant correlates. Among children with autism, RRBs remained stable over time. Autism Res 2013, 6: 584-595. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Joseph, Lisa; Thurm, Audrey; Farmer, Cristan; Shumway, Stacy] NIH, Pediat & Dev Neurosci Branch, Bethesda, MD 20892 USA. RP Joseph, L (reprint author), NIMH, Pediat & Dev Neurosci Branch, 10 Ctr Dr,MSC 1255,Bldg 10,Room 1C250, Bethesda, MD 20892 USA. EM jlisa@mail.nih.gov FU National Institute of Mental Health [NIMH] [NCT 00271622, 06-M-0065, NCT NCT00298246, 06-M-0102] FX This research was supported by the Intramural Program of the National Institute of Mental Health [NIMH], studies NCT 00271622, 06-M-0065 and NCT NCT00298246, 06-M-0102. The views expressed in this article do not necessarily represent the views of the NIMH, NIH, HHS, or the United Stated Government. The authors extend our gratitude for the children and their families who volunteered their time and efforts during this research. CR (APA) APA, 2000, DIAGN STAT MAN MENT Arnott B, 2010, J DEV BEHAV PEDIATR, V31, P223, DOI 10.1097/DBP.0b013e3181d5a2ad Barber AB, 2012, J AUTISM DEV DISORD, V42, P2006, DOI 10.1007/s10803-011-1434-3 Bishop SL, 2006, CHILD NEUROPSYCHOL, V12, P247, DOI 10.1080/09297040600630288 Bishop SL, 2013, J AUTISM DEV DISORD, V43, P1287, DOI 10.1007/s10803-012-1671-0 Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855 Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x Cohen J., 1988, STAT POWER ANAL BEHA, V2nd Cuccaro ML, 2003, CHILD PSYCHIAT HUM D, V34, P3, DOI 10.1023/A:1025321707947 Elliott C., 2007, DIFFERENTIAL ABILITY Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P57, DOI 10.1007/s10803-008-0599-x Evans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925 Gabriels RL, 2005, RES DEV DISABIL, V26, P169, DOI 10.1016/j.ridd.2004.05.003 Gotham K, 2012, PEDIATRICS, V130, pE1278, DOI 10.1542/peds.2011-3668 Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Hattier MA, 2011, RES DEV DISABIL, V32, P2346, DOI 10.1016/j.ridd.2011.07.028 Honey E, 2008, J AUTISM DEV DISORD, V38, P1439, DOI 10.1007/s10803-006-0191-1 Kim SH, 2012, J AUTISM DEV DISORD, V42, P82, DOI 10.1007/s10803-011-1213-1 Kim SH, 2010, AUTISM RES, V3, P162, DOI 10.1002/aur.142 Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x Leekam S, 2007, J CHILD PSYCHOL PSYC, V48, P1131, DOI 10.1111/j.1469-7610.2007.01778.x Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Mandy W, 2012, J AUTISM DEV DISORD, V42, P1304, DOI 10.1007/s10803-011-1356-0 Mandy W, 2011, AUTISM RES, V4, P121, DOI 10.1002/aur.178 Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730 Mirenda P, 2010, J AUTISM DEV DISORD, V40, P1521, DOI 10.1007/s10803-010-1012-0 Mooney EL, 2009, J AUTISM DEV DISORD, V39, P765, DOI 10.1007/s10803-008-0680-5 Moore V, 2003, AUTISM, V7, P47, DOI 10.1177/1362361303007001018 Mullen E, 1995, MULLEN SCALES EARLY Richler J, 2007, J AUTISM DEV DISORD, V37, P73, DOI 10.1007/s10803-006-0332-6 Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265 Rutter M., 2003, AUTISM DIAGNOSTIC IN Rutter M., 2003, MANUAL SOCIAL COMMUN Sipes M, 2011, RES AUTISM SPECT DIS, V5, P1465, DOI 10.1016/j.rasd.2011.02.007 SPSS Inc, 2010, SPSS VERS 19 0 WIND Stone WL, 1999, J CHILD PSYCHOL PSYC, V40, P219, DOI 10.1017/S0021963098003370 Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278 Turner M. A., 1995, THESIS U CAMBRIDGE U NR 40 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 584 EP 595 DI 10.1002/aur.1316 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900012 PM 23868881 ER PT J AU Ben-Itzchak, E Ben-Shachar, S Zachor, DA AF Ben-Itzchak, Esther Ben-Shachar, Shay Zachor, Ditza A. TI Specific Neurological Phenotypes in Autism Spectrum Disorders Are Associated with Sex Representation SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; male:female ratio; microcephaly; macrocephaly; developmental regression, minor neurological and musculoskeletal deficits, seizures ID HEAD CIRCUMFERENCE; BRAIN OVERGROWTH; EPILEPSY; CHILDREN; REGRESSION; CONNECTIVITY; PREVALENCE; FEATURES; TIME; EEG AB Autism spectrum disorder (ASD) is a heritable disorder occurring predominantly in males. The aim of this study was to compare sex differences in the prevalence of specific neurological phenotypes commonly described in ASD. The study included 663 participants, aged 18 months to 15 years, diagnosed with ASD. Neurological and behavioral assessments were performed using standardized tests, and obtaining medical, developmental, and familial histories from the parents. Phenotypes under investigation were macro- and microcephaly, developmental regression, minor neurological and musculoskeletal deficits (MNMD), and seizures. Male:female ratio in the ASD group was 6.7:1. No sex differences in autism severity, cognitive ability, and adaptive functioning were noted. Mean head circumference percentile for males (50.1 +/- 25.6) was significantly larger than females (43.4 +/- 30.2). Micro- and macrocephaly were more frequent in ASD than expected (5.9%; 18.1%, respectively). Microcephaly in females (15.1%) was significantly more prevalent than in males (4.5%). The prevalence of macrocephaly in both sexes did not differ significantly. Regression was noted in 30.2% of the females with ASD, significantly higher than in males (18.9%). MNMD was documented in 73.8% of the females, significantly higher than in males (57.1%). M:F ratio decreased in a group with two or more phenotypes (3.6:1), while male predominance was more significant in the group without phenotypes (13.6:1). Neurological phenotypes associated with ASD are more prevalent in females than in males, resulting in more complex clinical and neurological manifestations in females. Therefore, involvement of different etiologies is suggested in ASD in females. Autism Res 2013, 6: 596-604. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Ben-Itzchak, Esther] Ariel Univ Ctr Samaria, Dept Commun Disorders, Ariel, Israel. [Ben-Itzchak, Esther; Zachor, Ditza A.] Assaf Harofeh Med Ctr, Autism Ctr, Dept Pediat, IL-70300 Zerifin, Israel. [Ben-Shachar, Shay] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Genet Inst, IL-69978 Tel Aviv, Israel. [Zachor, Ditza A.] Tel Aviv Univ, IL-69978 Tel Aviv, Israel. RP Ben-Itzchak, E (reprint author), Assaf Harofeh Med Ctr, Autism Ctr, IL-70300 Zerifin, Israel. EM benitze@ariel.ac.il CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030 Baird G, 2008, J AUTISM DEV DISORD, V38, P1827, DOI 10.1007/s10803-008-0571-9 Bayley N, 1993, BAYLEY SCALES INFANT Boltor PF, 2011, BRIT J PSYCHIAT, V198, P289, DOI 10.1192/bjp.bp.109.076877 Carter AS, 2007, J AUTISM DEV DISORD, V37, P86, DOI 10.1007/s10803-006-0331-7 Courchesne E, 2005, INT J DEV NEUROSCI, V23, P153, DOI 10.1016/j.ijdevneu.2005.01.003 Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016 Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337 De Jong M, 2011, DEV MED CHILD NEUROL, V53, P641, DOI 10.1111/j.1469-8749.2011.03971.x Deutsch Curtis K., 1994, P151 Deutsch CK, 2003, J AUTISM DEV DISORD, V33, P209, DOI 10.1023/A:1022903913547 Dworzynski K, 2012, J AM ACAD CHILD PSY, V51, P788, DOI 10.1016/j.jaac.2012.05.018 Fombonne E, 1999, J AUTISM DEV DISORD, V29, P113, DOI 10.1023/A:1023036509476 Fombonne E, 2003, JAMA-J AM MED ASSOC, V289, P87, DOI 10.1001/jama.289.1.87 Hartley SL, 2009, J AUTISM DEV DISORD, V39, P1715, DOI 10.1007/s10803-009-0810-8 Holtmann M, 2007, DEV MED CHILD NEUROL, V49, P361 Hughes JR, 2005, CLIN EEG NEUROSCI, V36, P15 Kagan-Kushnir T, 2005, J CHILD NEUROL, V20, P197 Kaufman AS, 1983, KAUFMAN ASSESSMENT B Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015 Lord C., 1999, AUTISM DIAGNOSTIC OB LORD C, 1982, J AUTISM DEV DISORD, V12, P317, DOI 10.1007/BF01538320 LORD C, 1985, J AUTISM DEV DISORD, V15, P185, DOI 10.1007/BF01531604 Mandy H., 2012, J AUTISM DEV DISORD, V42, P1304 MCLENNAN JD, 1993, J AUTISM DEV DISORD, V23, P217, DOI 10.1007/BF01046216 Miles JH, 2000, AM J MED GENET, V95, P339, DOI 10.1002/1096-8628(20001211)95:4<339::AID-AJMG9>3.0.CO;2-B Miles JH, 2005, AM J MED GENET A, V135A, P171, DOI 10.1002/ajmg.a.30590 Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002 Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945 Mraz KD, 2007, J CHILD NEUROL, V22, P700, DOI 10.1177/0883073807304005 Mullen E, 1995, MULLEN SCALES EARLY NELLHAUS G, 1968, PEDIATRICS, V41, P106 Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007 Parr JR, 2011, J AUTISM DEV DISORD, V41, P332, DOI 10.1007/s10803-010-1055-2 Pilowsky T, 1998, J AUTISM DEV DISORD, V28, P143, DOI 10.1023/A:1026092632466 ROSSI PG, 1995, BRAIN DEV-JPN, V17, P169, DOI 10.1016/0387-7604(95)00019-8 Rutter M., 2003, AUTISM DIAGNOSTIC IN Schaaf CP, 2011, NEURON, V70, P806, DOI 10.1016/j.neuron.2011.05.025 Shumway S, 2011, J AUTISM DEV DISORD, V41, P1727, DOI 10.1007/s10803-011-1203-3 Sparrow S, 1984, VINELAND ADAPTIVE BE Stefanatos GA, 2008, NEUROPSYCHOL REV, V18, P305, DOI 10.1007/s11065-008-9073-y STEFFENBURG S, 1986, BRIT J PSYCHIAT, V149, P81, DOI 10.1192/bjp.149.1.81 Szatmari P, 2012, AM J MED GENET B, V159B, P5, DOI 10.1002/ajmg.b.31238 Thorndike RL, 1986, STANFORD BINET INTEL Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6 TUCHMAN RF, 1991, PEDIATRICS, V88, P1219 VOLKMAR FR, 1993, J AUTISM DEV DISORD, V23, P579, DOI 10.1007/BF01046103 Webb S. J., 2007, J CHILD NEUROL, V22, P182 Wechsler D., 2003, WECHSLER INTELLIGENC Wechsler D., 1989, WECHSLER PRESCHOOL P Zachor DA, 2010, RES AUTISM SPECT DIS, V4, P438, DOI 10.1016/j.rasd.2009.10.016 Zwaigenbaum L, 2012, J AUTISM DEV DISORD, V42, P2585, DOI 10.1007/s10803-012-1515-y NR 53 TC 6 Z9 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 596 EP 604 DI 10.1002/aur.1319 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900013 PM 23873852 ER PT J AU Eigsti, IM Fein, DA AF Eigsti, Inge-Marie Fein, Deborah A. TI More Is Less: Pitch Discrimination and Language Delays in Children with Optimal Outcomes from Autism SO AUTISM RESEARCH LA English DT Article DE language; language delays; auditory perception; autism; long-term outcomes ID ENGLISH-LEARNING INFANTS; SPECTRUM DISORDERS; REPETITIVE BEHAVIORS; HEAD CIRCUMFERENCE; SPEECH; ABILITY; SEGMENTATION; IMPAIRMENT; INDIVIDUALS; SENSITIVITY AB The autism spectrum disorders (ASD) are neurodevelopmental disorders diagnosed behaviorally but associated with differences in brain development. Individuals with ASD exhibit superior auditory perceptual skills, which may correlate with ASD symptomatology, particularly language skills. We describe findings from individuals diagnosed with ASD before age five, who now have no symptoms (e.g., having optimal outcomes). Unlike an ASD group, which shows heightened pitch discrimination, the Optimal Outcome group's abilities do not differ from those of typically developing controls. Furthermore, pitch discrimination is associated with both current autism symptomatology and early-language milestones. Findings illuminate processes associated with resolution of autism. We also discuss a specific mechanism by which heightened auditory discrimination leads to language delays in ASD. Autism Res 2013, 6: 605-613. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Eigsti, Inge-Marie; Fein, Deborah A.] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA. RP Eigsti, IM (reprint author), Univ Connecticut, 406 Babbidge Rd,Unit 1020, Storrs, CT 06269 USA. EM inge-marie.eigsti@uconn.edu FU NIMH [R01 MH076189-01A1] FX Research supported by funding from NIMH R01 MH076189-01A1 to DF. None of the authors declares a conflict of interest. A number of research assistants were instrumental in data collection, including Eva Troyb, Alyssa Orinstein, Katherine Tyson, Molly Helt, and Michael Rosenthal, and we acknowledge their contributions. We gratefully acknowledge the time and effort of participating families and their children. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Aylward EH, 2002, NEUROLOGY, V59, P175 Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004 Boersma P., 2011, PRAAT DOING PHONETIC Bonnel A, 2003, J COGNITIVE NEUROSCI, V15, P226, DOI 10.1162/089892903321208169 Bonnel A, 2010, NEUROPSYCHOLOGIA, V48, P2465, DOI 10.1016/j.neuropsychologia.2010.04.020 Bortfeld H, 2010, COGNITIVE PSYCHOL, V60, P241, DOI 10.1016/j.cogpsych.2010.01.002 Boyd BA, 2010, AUTISM RES, V3, P78, DOI 10.1002/aur.124 Cardy JEO, 2008, INT J PSYCHOPHYSIOL, V68, P170, DOI 10.1016/j.ijpsycho.2007.10.015 Casanova MF, 2002, NEUROLOGY, V58, P428 Chen YH, 2009, J AUTISM DEV DISORD, V39, P635, DOI 10.1007/s10803-008-0663-6 Coffey-Corina S, 2008, J ACOUST SOC AM, V123, P3742, DOI 10.1121/1.2935280 Constantino JN, 2007, J AUTISM DEV DISORD, V37, P1256, DOI 10.1007/s10803-006-0269-9 Dunn L. M., 2007, PEABODY PICTURE VOCA Eaves LC, 1996, J AUTISM DEV DISORD, V26, P557, DOI 10.1007/BF02172276 Eigsti I. M., 2009, J CHILD LANG, V19, P1 Fein D, 2013, J CHILD PSYCHOL PSYC, V54, P195, DOI 10.1111/jcpp.12037 GERKEN L, 1994, COGNITION, V51, P237, DOI 10.1016/0010-0277(94)90055-8 GOODSITT JV, 1993, J CHILD LANG, V20, P229 Heaton P, 2008, COGN NEUROPSYCHOL, V25, P771, DOI 10.1080/02643290802336277 Heaton P, 2005, J AUTISM DEV DISORD, V35, P787, DOI 10.1007/s10803-005-0024-7 Heaton P, 2003, J CHILD PSYCHOL PSYC, V44, P543, DOI 10.1111/1469-7610.00143 Heaton P, 1998, MUSIC PERCEPT, V15, P291 Helt M, 2008, NEUROPSYCHOL REV, V18, P339, DOI 10.1007/s11065-008-9075-9 Hus V, 2011, J CHILD PSYCHOL PSYC, V52, P753, DOI 10.1111/j.1469-7610.2011.02398.x Jarvinen-Pasley A, 2008, DEVELOPMENTAL SCI, V11, P109, DOI 10.1111/j.1467-7687.2007.00644.x Jones CRG, 2009, NEUROPSYCHOLOGIA, V47, P2850, DOI 10.1016/j.neuropsychologia.2009.06.015 Jusczyk PW, 1999, COGNITIVE PSYCHOL, V39, P159, DOI 10.1006/cogp.1999.0716 Kuhl PK, 2005, DEVELOPMENTAL SCI, V8, pF1, DOI 10.1111/j.1467-7687.2004.00384.x Kuhl PK, 2003, P NATL ACAD SCI USA, V100, P9096, DOI 10.1073/pnas.1532872100 Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465 Lengeris A, 2010, J ACOUST SOC AM, V128, P3757, DOI 10.1121/1.3506351 Lepisto T, 2005, BRAIN RES, V1066, P147, DOI 10.1016/j.brainres.2005.10.052 Lord C., 2002, AUTISM DIAGNOSTIC OB Loui P, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2011.00111 Marshall PJ, 2009, DEVELOPMENTAL SCI, V12, P568, DOI 10.1111/j.1467-7687.2008.00808.x Mayo J, 2013, J AUTISM DEV DISORD, V43, P253, DOI 10.1007/s10803-012-1558-0 McArthur GM, 2004, J SPEECH LANG HEAR R, V47, P527, DOI 10.1044/1092-4388(2004/041) Miller LK, 1999, PSYCHOL BULL, V125, P31, DOI 10.1037/0033-2909.125.1.31 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Mottron L, 2000, J CHILD PSYCHOL PSYC, V41, P1057, DOI 10.1017/S0021963099006253 Mraz KD, 2009, J CHILD NEUROL, V24, P833, DOI 10.1177/0883073808331345 Muller RA, 2004, BRAIN LANG, V89, P329, DOI 10.1016/S0093-934X(03)00346-8 Nazzi T, 2005, LANG SPEECH, V48, P279 O'Riordan M, 2006, J AUTISM DEV DISORD, V36, P665, DOI 10.1007/s10803-006-0106-1 Rutter M., 2003, ADI R AUTISM DIAGNOS Rutter M., 2003, SOCIAL COMMUNICATION Seidl A, 2008, J CHILD LANG, V35, P1, DOI 10.1017/S0305000907008215 Seltzer MM, 2003, J AUTISM DEV DISORD, V33, P565, DOI 10.1023/B:JADD.0000005995.02453.0b Semel E., 2003, CLIN EVALUATION LANG, V4th Singh L., 2008, LANGUAGE LEARNING DE, V4, P157, DOI DOI 10.1080/15475440801922131 Son JY, 2008, COGNITION, V108, P626, DOI 10.1016/j.cognition.2008.05.002 Swaminathan J, 2008, NEUROREPORT, V19, P1163, DOI 10.1097/WNR.0b013e3283088d31 Wechsler D., 1999, MANUAL WECHSLER ABBR Werker JF, 2005, TRENDS COGN SCI, V9, P519, DOI 10.1016/j.tics.2005.09.003 NR 55 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 605 EP 613 DI 10.1002/aur.1324 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900014 PM 23929787 ER PT J AU Haffey, A Press, C O'Connell, G Chakrabarti, B AF Haffey, Anthony Press, Clare O'Connell, Garret Chakrabarti, Bhismadev TI Autistic Traits Modulate Mimicry of Social but not Nonsocial Rewards SO AUTISM RESEARCH LA English DT Article DE reward; imitation; social; nonsocial; autism; empathy; mimicry ID EMOTIONAL FACIAL EXPRESSIONS; AUTOMATIC IMITATION; SPECTRUM DISORDERS; FUNCTIONING AUTISM; ASPERGER-SYNDROME; EMPATHY; CHILDREN; MECHANISMS; QUOTIENT; FACE AB Autism Spectrum Conditions (ASC) are associated with diminished responsiveness to social stimuli, and especially to social rewards such as smiles. Atypical responsiveness to social rewards, which reinforce socially appropriate behavior in children, can potentially lead to a cascade of deficits in social behavior. Individuals with ASC often show diminished spontaneous mimicry of social stimuli in a natural setting. In the general population, mimicry is modulated both by the reward value and the sociality of the stimulus (i.e., whether the stimulus is perceived to belong to a conspecific or an inanimate object). Since empathy and autistic traits are distributed continuously in the general population, this study aimed to test if and how these traits modulated automatic mimicry of rewarded social and nonsocial stimuli. High and low rewards were associated with human and robot hands using a conditioned learning paradigm. Thirty-six participants from the general population then completed a mimicry task involving performing a prespecified hand movement which was either compatible or incompatible with a hand movement presented to the participant. High autistic traits (measured using the Autism Spectrum Quotient, AQ) predicted lesser mimicry of high-reward than low-reward conditioned human hands, whereas trait empathy showed an opposite pattern of correlations. No such relations were observed for high-reward vs. low-reward conditioned robot hands. These results demonstrate how autistic traits and empathy modulate the effects of reward on mimicry of social compared to nonsocial stimuli. This evidence suggests a potential role for the reward system in underlying the atypical social behavior in individuals with ASC, who constitute the extreme end of the spectrum of autistic traits. Autism Res 2013, 6: 614-620. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Haffey, Anthony; Press, Clare; O'Connell, Garret; Chakrabarti, Bhismadev] Univ Reading, Sch Psychol & Clin Language Sci, Ctr Integrat Neurosci & Neurodynam, Reading RG6 6AL, Berks, England. [Press, Clare] Univ London, Birkbeck Coll, Dept Psychol Sci, London, England. RP Chakrabarti, B (reprint author), Univ Reading, Sch Psychol & Clin Language Sci, Ctr Integrat Neurosci & Neurodynam, Reading RG6 6AL, Berks, England. EM b.chakrabarti@reading.ac.uk FU MRC; ESRC-MRC; University of Reading FX BC is supported by an MRC New Investigator Research Grant. ATH is supported by an ESRC-MRC Interdisciplinary studentship. GO'C is supported by a University of Reading studentship. We are grateful to Thomas Sims, Carien van Reekum, and Tom Johnstone for helpful discussions. Data reported in this paper is available from www.bhismalab.org/publications CR Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00 Beall PM, 2008, J EXP CHILD PSYCHOL, V101, P206, DOI 10.1016/j.jecp.2008.04.004 Bird G, 2007, P ROY SOC B-BIOL SCI, V274, P3027, DOI 10.1098/rspb.2007.1019 Catmur C, 2009, PHILOS T R SOC B, V364, P2369, DOI 10.1098/rstb.2009.0048 Chakrabarti B, 2006, PROG BRAIN RES, V156, P403, DOI 10.1016/S0079-6123(06)56022-4 Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007 Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433 Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327 Dinstein I., 2008, LOND UK INT M AUT RE Ferrari P. F., 2007, ADV CONSCIOUSNESS RE, V68, P73 Ferrari PF, 2006, PLOS BIOL, V4, P1501, DOI 10.1371/journal.pbio.0040302 Haber S, 2009, NEUROPSYCHOPHARMACOL, V35, P4, DOI DOI 10.1038/NPP.2009.129 Harrison NA, 2010, SOC NEUROSCI-UK, V5, P393, DOI 10.1080/17470911003656330 Hermans EJ, 2006, PSYCHONEUROENDOCRINO, V31, P859, DOI 10.1016/j.psyneuen.2006.04.002 Hess U., 1999, MIMICRY FACTS FICTIO Heyes C, 2011, PSYCHOL BULL, V137, P463, DOI 10.1037/a0022288 Heyes C, 2001, TRENDS COGN SCI, V5, P253, DOI 10.1016/S1364-6613(00)01661-2 Hobson RP, 2008, J EXP CHILD PSYCHOL, V101, P170, DOI 10.1016/j.jecp.2008.04.007 Iacoboni M, 2009, ANNU REV PSYCHOL, V60, P653, DOI 10.1146/annurev.psych.60.110707.163604 Keysers C, 2010, NAT REV NEUROSCI, V11, P417, DOI 10.1038/nrn2833 Kohls G, 2011, J AUTISM DEV DISORD, V41, P1523, DOI 10.1007/s10803-011-1177-1 Lang P.J., 1999, INT AFFECTIVE PICTUR Likowski KU, 2008, J EXP SOC PSYCHOL, V44, P1065, DOI 10.1016/j.jesp.2007.10.007 Maringer M, 2011, EMOTION, V11, P181, DOI 10.1037/a0022596 Marsh AA, 2010, SOC COGN AFFECT NEUR, V5, P392, DOI 10.1093/scan/nsq004 McIntosh DN, 2006, DEVELOPMENTAL SCI, V9, P295, DOI 10.1111/j.1467-7687.2006.00492.x Minio-Paluello I, 2009, BIOL PSYCHIAT, V65, P55, DOI 10.1016/j.biopsych.2008.08.006 Press C, 2010, NEUROPSYCHOLOGIA, V48, P3291, DOI 10.1016/j.neuropsychologia.2010.07.012 Press C, 2005, COGNITIVE BRAIN RES, V25, P632, DOI 10.1016/j.cogbrainres.2005.08.020 Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119 Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162 Schmitz N, 2008, BRIT J PSYCHIAT, V192, P19, DOI 10.1192/bjp.bp.107.036921 Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122 Sims TB, 2012, PSYCHOPHYSIOLOGY, V49, P998, DOI 10.1111/j.1469-8986.2012.01377.x Sonnby-Borgstrom M, 2002, SCAND J PSYCHOL, V43, P433, DOI 10.1111/1467-9450.00312 STEIGER JH, 1980, PSYCHOL BULL, V87, P245, DOI 10.1037//0033-2909.87.2.245 Stel M, 2008, J AUTISM DEV DISORD, V38, P1250, DOI 10.1007/s10803-007-0505-y Stel M, 2010, EXP PSYCHOL, V57, P412, DOI 10.1027/1618-3169/a000050 NR 39 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 614 EP 620 DI 10.1002/aur.1323 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900015 PM 23939872 ER PT J AU Levin-Decanini, T Maltman, N Francis, SM Guter, S Anderson, GM Cook, EH Jacob, S AF Levin-Decanini, Tal Maltman, Nell Francis, Sunday M. Guter, Steve Anderson, George M. Cook, Edwin H. Jacob, Suma TI Parental Broader Autism Subphenotypes in ASD Affected Families: Relationship to Gender, Child's Symptoms, SSRI Treatment, and Platelet Serotonin SO AUTISM RESEARCH LA English DT Article DE broader autism phenotype; serotonin; autism; SSRI ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; MULTIPLE-INCIDENCE; 1ST-DEGREE RELATIVES; REPETITIVE BEHAVIOR; TWIN PAIRS; DIAGNOSTIC INTERVIEW; MENTAL-RETARDATION; BLOOD SEROTONIN; WHOLE-BLOOD AB Relationships between parental broader autism phenotype (BAP) scores, gender, selective serotonin reuptake inhibitor (SSRI) treatment, serotonin (5HT) levels, and the child's symptoms were investigated in a family study of autism spectrum disorder (ASD). The Broader Autism Phenotype Questionnaire (BAPQ) was used to measure the BAP of 275 parents. Fathers not taking SSRIs (F-SSRI; n=115) scored significantly higher on BAP Total and Aloof subscales compared to mothers not receiving treatment (M-SSRI; n=136.) However, mothers taking SSRIs (M+SSRI; n=19) scored higher than those not taking medication on BAP Total and Rigid subscales, and they were more likely to be BAPQ Total, Aloof, and Rigid positive. Significant correlations were noted between proband autism symptoms and parental BAPQ scores such that Total, Aloof, and Rigid subscale scores of F-SSRI correlated with proband restricted repetitive behavior (RRB) measures on the ADOS, CRI, and RBS-R. However, only the Aloof subscale score of M+SSRI correlated with proband RRB on the ADOS. The correlation between the BAPQ scores of mothers taking SSRIs and child scores, as well as the increase in BAPQ scores of this group of mothers, requires careful interpretation and further study because correlations would not withstand multiple corrections. As expected by previous research, significant parent-child correlations were observed for 5HT levels. However, 5HT levels were not correlated with behavioral measures. Study results suggest that the expression of the BAP varies not only across parental gender, but also across individuals using psychotropic medication and those who do not. Autism Res 2013, 6: 621-630. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Levin-Decanini, Tal; Maltman, Nell; Francis, Sunday M.; Guter, Steve; Cook, Edwin H.] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA. [Anderson, George M.] Yale Univ, Sch Med, Dept Child Psychiat, New Haven, CT USA. [Anderson, George M.] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA. [Jacob, Suma] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA. RP Jacob, S (reprint author), Univ Minnesota, Wallin Med Biosci Bldg,2101 6th St SE, Minneapolis, MN 55455 USA. EM sjacob@umn.edu FU NIH Autism Center of Excellence [P50 HD055751, K23MH082121] FX This work was supported in part by NIH Autism Center of Excellence P50 HD055751 (EHC) and K23MH082121 (SJ). CR ABRAMSON RK, 1989, J AUTISM DEV DISORD, V19, P397, DOI 10.1007/BF02212938 American Psychiatric Association, 2000, DIAGN STAT MAN MENT ANDERSON GM, 1987, LIFE SCI, V40, P1063, DOI 10.1016/0024-3205(87)90568-6 Anderson GM, 2004, INT J DEV NEUROSCI, V22, P397, DOI 10.1016/j.ijdevneu.2004.06.006 BAILEY A, 1995, PSYCHOL MED, V25, P63 Bernier R, 2012, AUTISM RES, V5, P13, DOI 10.1002/aur.226 Bishop SL, 2013, J AUTISM DEV DISORD, V43, P1287, DOI 10.1007/s10803-012-1671-0 Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855 Bolte S, 2003, PSYCHOL MED, V33, P907, DOI 10.1017/S0033291703007438 BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004 Carter AS, 2009, J CLIN PSYCHOL, V65, P1270, DOI 10.1002/jclp.20634 Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9 Cook EH, 1997, MOL PSYCHIATR, V2, P247 Cook E H Jr, 1990, J Neuropsychiatry Clin Neurosci, V2, P268 Cuccaro ML, 2003, CHILD PSYCHIAT HUM D, V34, P3, DOI 10.1023/A:1025321707947 Davidson J, 2012, J AUTISM DEV DISORDE, DOI 10.1007/s10803-012-1492-1 De la Marche W, 2012, AUTISM, V16, P247, DOI 10.1177/1362361311421776 DEMYER MK, 1972, J AUTISM CHILD SCHIZ, V2, P49, DOI 10.1007/BF01537626 Devlin B, 2005, MOL PSYCHIATR, V10, P1110, DOI 10.1038/sj.mp.4001724 Evans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925 Fineberg NA, 2010, NEUROPSYCHOPHARMACOL, V35, P591, DOI 10.1038/npp.2009.185 FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76 Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3 Ingersoll B, 2011, AUTISM RES, V4, P143, DOI 10.1002/aur.170 KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100 KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P205, DOI 10.1007/BF01058151 KUPERMAN S, 1985, J AM ACAD CHILD PSY, V24, P186, DOI 10.1016/S0002-7138(09)60446-5 Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z LEVENTHAL BL, 1990, J AUTISM DEV DISORD, V20, P499, DOI 10.1007/BF02216055 Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223 Lord C., 1999, AUTISM DIAGNOSTIC OB LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Losh M, 2007, J CHILD PSYCHOL PSYC, V48, P105, DOI 10.1111/j.1469-7610.2006.01594.x Losh M, 2006, DEV PSYCHOL, V42, P809, DOI 10.1037/0012-1649.42.5.809 Losh M, 2008, AM J MED GENET B, V147B, P424, DOI 10.1002/ajmg.b.30612 Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34 MELTZER HY, 1988, PSYCHIAT RES, V24, P263, DOI 10.1016/0165-1781(88)90108-4 Moller-Leimkuhler AM, 2002, J AFFECT DISORDERS, V71, P1, DOI 10.1016/S0165-0327(01)00379-2 Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0 Ober C, 2001, AM J HUM GENET, V69, P1068, DOI 10.1086/324025 Piven J, 1999, AM J PSYCHIAT, V156, P557 PIVEN J, 1994, PSYCHOL MED, V24, P783 Piven J, 2001, AM J MED GENET, V105, P34, DOI 10.1002/1096-8628(20010108)105:1<34::AID-AJMG1052>3.0.CO;2-D Piven J, 1997, AM J PSYCHIAT, V154, P185 PIVEN J, 1991, J AUTISM DEV DISORD, V21, P51, DOI 10.1007/BF02206997 Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98 SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8 Seidman I, 2012, J AUTISM DEV DISORD, V42, P837, DOI 10.1007/s10803-011-1315-9 SMALLEY SL, 1995, AM J MED GENET, V60, P19, DOI 10.1002/ajmg.1320600105 Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648 Szatmari P, 2000, J CHILD PSYCHOL PSYC, V41, P579, DOI 10.1017/S0021963099005831 Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109 NR 55 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 621 EP 630 DI 10.1002/aur.1322 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900016 PM 23956104 ER PT J AU Yager, J Iarocci, G AF Yager, Jodi Iarocci, Grace TI The Development of the Multidimensional Social Competence Scale: A Standardized Measure of Social Competence in Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; social competence; multidimensional social competence scale; psychometric properties ID INTERPERSONAL COMPETENCE; CHILDREN; BEHAVIOR; CLASSIFICATION AB Autism and its related disorders are commonly described as lying along a continuum that ranges in severity and are collectively referred to as autism spectrum disorders (ASDs). Although all individuals with ASD meet the social impairment diagnostic criteria outlined in the DSM-IV-TR, they do not present with the same social difficulties. The variability in the expression and severity of social competence is particularly evident among the group of individuals with high-functioning ASD who appear to have difficulty applying their average to above average intelligence in a social context. There is a striking paucity of empirical research investigating individual differences in social functioning among individuals with high-functioning ASD. It is possible that more detailed investigations of social competence have been impeded by the lack of standardized measures available to assess the nature and severity of social impairment. The aim of the current study was to develop and evaluate a parent rating scale capable of assessing individual differences in social competence (i.e. strengths and challenges) among adolescents with ASD: the Multidimensional Social Competence Scale (MSCS). Results from confirmatory factor analyses supported the hypothesized multidimensional factor structure of the MSCS. Seven relatively distinct domains of social competence were identified including social motivation, social inferencing, demonstrating empathic concern, social knowledge, verbal conversation skills, nonverbal sending skills, and emotion regulation. Psychometric evidence provided preliminary support for the reliability and validity of the scale. Possible applications of this promising new parent rating scale in both research and clinical settings are discussed. Autism Res 2013, 6: 631-641. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Yager, Jodi; Iarocci, Grace] Simon Fraser Univ, Autism & Dev Disorders Lab, Burnaby, BC V5A 1S6, Canada. RP Yager, J (reprint author), Simon Fraser Univ, Autism & Dev Disorders Lab, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada. EM jyager@sfu.ca FU Autism Research Training Program; Canadian Institutes of Health Research (CIHR); National Alliance for Autism Research (NAAR); Fonds de la recherche en sante due Quebec (FRSQ); Social Sciences and Humanities Research Council of Canada (SSHRC); Michael Smith Foundation for Health Research (MSFHR); Human Early Learning Partnership (HELP); Laurel Foundation; SSHRC; MSFHR FX Jodi Yager's work on this study was supported by doctoral fellowships from the Autism Research Training Program (jointly funded by Canadian Institutes of Health Research (CIHR), National Alliance for Autism Research (NAAR), and Fonds de la recherche en sante due Quebec (FRSQ)), the Social Sciences and Humanities Research Council of Canada (SSHRC), the Michael Smith Foundation for Health Research (MSFHR), and the Human Early Learning Partnership (HELP). This research was also supported by a research grant from the Laurel Foundation, the SSHRC, and an MSFHR scholar award to Grace Iarocci. We express our deep gratitude to the adolescents and families who participated in this study. We also thank our lab volunteers, Krista Johnston, Vanessa Vondruska, and Sara Clark, who helped at various stages of this research. CR Beglinger LJ, 2001, J AUTISM DEV DISORD, V31, P411, DOI 10.1023/A:1010616719877 Brown T. A., 2006, CONFIRMATORY FACTOR BUHRMESTER D, 1988, J PERS SOC PSYCHOL, V55, P991, DOI 10.1037/0022-3514.55.6.991 BUHRMESTER D, 1990, CHILD DEV, V61, P1101, DOI 10.1111/j.1467-8624.1990.tb02844.x Cohen D. J., 1987, HDB AUTISM PERVASIVE, P20 Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2 Constantino JN, 2005, SOCIAL RESPONSIVENES Coolican J, 2008, J AUTISM DEV DISORD, V38, P190, DOI 10.1007/s10803-007-0368-2 Eisenberg N., 1984, SCH PSYCHOL REV, V13, P267 Fein D, 1999, CHILD NEUROPSYCHOL, V5, P1, DOI 10.1076/chin.5.1.1.7075 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 Iarocci G, 2008, INT REV RES MENT RET, V35, P87, DOI 10.1016/S0074-7750(07)35003-9 Iarocci G, 2007, BRAIN COGNITION, V65, P112, DOI 10.1016/j.bandc.2007.01.008 Lecavalier L, 2004, J AUTISM DEV DISORD, V34, P709, DOI 10.1007/s10803-004-5291-1 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 Mundy P., 2006, DEV PSYCHOPATHOL, V1, P293 NEWCOMB AF, 1993, PSYCHOL BULL, V113, P99, DOI 10.1037//0033-2909.113.1.99 Pennington B. F., 1991, ROCH S DEV PSYCH MOD, P117 Rao PA, 2008, J AUTISM DEV DISORD, V38, P353, DOI 10.1007/s10803-007-0402-4 Roid G. H., 2003, STANFORD BINET INTEL Rombough A. H., 2012, COGNITIVE NEUROSCIEN, P221 RoseKrasnor L, 1997, SOC DEV, V6, P111, DOI 10.1111/1467-9507.00029 Rutter M., 2003, AUTISM DIAGNOSTIC IN Schneider RJ, 1996, PERS INDIV DIFFER, V21, P469, DOI 10.1016/0191-8869(96)00084-0 Shankar S. G., 2004, PHILOS PSYCHIAT PSYC, V11, P219, DOI 10.1353/ppp.2004.0068 Streiner D, 2003, HLTH MEASUREMENT SCA Tsai L. Y., 1992, HIGH FUNCTIONING IND, P11 GUADAGNOLI E, 1988, PSYCHOL BULL, V103, P265, DOI 10.1037//0033-2909.103.2.265 Volkmar F. R., 2000, ASPERGER SYNDROME, P25 Volkmar F.R., 2005, HDB AUTISM PERVASIVE, V1, P5 Ward-King J, 2010, J AUTISM DEV DISORD, V40, P1285, DOI 10.1007/s10803-010-0987-x WATERS E, 1983, DEV REV, V3, P79, DOI 10.1016/0273-2297(83)90010-2 Williams White Susan, 2007, J Autism Dev Disord, V37, P1858, DOI 10.1007/s10803-006-0320-x WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288 NR 35 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 631 EP 641 DI 10.1002/aur.1331 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900017 PM 24108618 ER PT J AU Roine, U Roine, T Salmi, J Nieminen-Von Wendt, T Leppamaki, S Rintahaka, P Tani, P Leemans, A Sams, M AF Roine, Ulrika Roine, Timo Salmi, Juha Nieminen-Von Wendt, Taina Leppamaki, Sami Rintahaka, Pertti Tani, Pekka Leemans, Alexander Sams, Mikko TI Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study SO AUTISM RESEARCH LA English DT Article DE diffusion tensor imaging (DTI); clinical psychiatry; neuroimaging; autism spectrum disorder ID HIGH-FUNCTIONING AUTISM; NORMAL SEX-DIFFERENCES; SPATIAL-STATISTICS; HUMAN BRAIN; SPECTRUM DISORDERS; DTI ANALYSES; MRI DATA; CONNECTIVITY; ABNORMALITIES; PATHWAYS AB To investigate whether there are global white matter (WM) differences between autistic and healthy adults, we performed diffusion tensor imaging (DTI) in 14 male adults with Asperger syndrome (AS) and 19 gender-, age-, and intelligence quotient-matched controls. We focused on individuals with high-functioning autism spectrum disorder (ASD), AS, to decrease heterogeneity caused by large variation in the cognitive profile. Previous DTI studies of ASD have mainly focused on finding local changes in fractional anisotropy (FA) and mean diffusivity (MD), two indexes used to characterize microstructural properties of WM. Although the local or voxel-based approaches may be able to provide detailed information in terms of location of the observed differences, such results are known to be highly sensitive to partial volume effects, registration errors, or placement of the regions of interest. Therefore, we performed global histogram analyses of (a) whole-brain tractography results and (b) skeletonized WM masks. In addition to the FA and MD, the planar diffusion coefficient (CP) was computed as it can provide more specific information of the complexity of the neural structure. Our main finding indicated that adults with AS had higher mean FA values than controls. A less complex neural structure in adults with AS could have explained the results, but no significant difference in CP was found. Our results suggest that there are global abnormalities in the WM tissue of adults with AS. Autism Res 2013, 6: 642-650. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Roine, Ulrika; Salmi, Juha; Sams, Mikko] Aalto Univ, Dept Biomed Engn & Computat Sci, Brain & Mind Lab, Espoo, Finland. [Roine, Timo] Univ Antwerp, Dept Phys, iMinds Vis Lab, B-2020 Antwerp, Belgium. [Nieminen-Von Wendt, Taina] Neuropsychiat Rehabil & Med Ctr Neuromental, Helsinki, Finland. [Leppamaki, Sami; Rintahaka, Pertti; Tani, Pekka] Univ Helsinki, Dept Psychiat, Cent Hosp, Clin Neuropsychiat, SF-00180 Helsinki, Finland. [Leppamaki, Sami] Finnish Inst Occupat Hlth, Helsinki, Finland. [Leemans, Alexander] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands. [Sams, Mikko] Aalto Univ, Adv Magnet Imaging Ctr, Espoo, Finland. RP Roine, U (reprint author), Aalto Univ, Sch Sci, Dept Biomed Engn & Computat Sci, POB 12200, FI-00076 Aalto, Finland. EM ulrika.roine@helsinki.fi RI Sams, Mikko/G-7060-2012; Leemans, Alexander/A-1784-2011; Roine, Timo/M-5865-2013 OI Roine, Timo/0000-0002-3104-9734 FU Academy of Finland [259952, 129670] FX Grant sponsor Academy of Finland; Grant number: 259952.Grant sponsor Academy of Finland; Grant number: 129670. CR Barnea-Goraly N, 2010, ARCH GEN PSYCHIAT, V67, P1052, DOI 10.1001/archgenpsychiatry.2010.123 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Baron-Cohen S, 2004, J AUTISM DEV DISORD, V34, P163, DOI 10.1023/B:JADD.0000022607.19833.00 Baron-Cohen S, 2003, PHILOS T ROY SOC B, V358, P361, DOI 10.1098/rstb.2002.1206 Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643 BASSER PJ, 1994, BIOPHYS J, V66, P259 Beacher FD, 2012, AM J NEURORADIOL, V33, P83, DOI 10.3174/ajnr.A2880 Beaulieu C, 2002, NMR BIOMED, V15, P435, DOI 10.1002/nbm.782 Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004 Benton A. L., 1983, CONTRIBUTIONS NEUROP, P30 Billeci L, 2012, BMC NEUROL, V12, DOI 10.1186/1471-2377-12-148 Bloemen OJN, 2010, AUTISM RES, V3, P203, DOI 10.1002/aur.146 Bode MK, 2011, ACTA RADIOL, V52, P1169, DOI 10.1258/ar.2011.110197 Cascio C., 2012, J INTELLECTUAL DISAB, DOI 10.1111/j.1365-2788.2012.01599.x Catani M, 2008, NEUROIMAGE, V41, P1184, DOI 10.1016/j.neuroimage.2008.03.041 Cercignani M, 2010, DIFFUSION MRI THEORY, P485 Conturo TE, 2008, J INT NEUROPSYCH SOC, V14, P933, DOI 10.1017/S1355617708081381 Deprez S., 2013, BRAIN IMAGING BEHAV, P1 Ennis DB, 2006, MAGNET RESON MED, V55, P136, DOI 10.1002/mrm.20741 Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083 Frith C, 2003, NOVART FDN SYMP, V251, P149 Groen WB, 2011, J PSYCHIATR NEUROSCI, V36, P32, DOI 10.1503/jpn.090100 Hsu JL, 2010, NEUROIMAGE, V49, P32, DOI 10.1016/j.neuroimage.2009.08.031 Hsu JL, 2008, NEUROIMAGE, V39, P566, DOI 10.1016/j.neuroimage.2007.09.017 Iidaka T, 2012, NEUROSCI LETT, V510, P154, DOI 10.1016/j.neulet.2012.01.029 Jeurissen B., 2012, HUMAN BRAIN MAPPING, DOI 10.1002/hbm.22099 Jones DK, 2010, NMR BIOMED, V23, P803, DOI 10.1002/nbm.1543 Jones DK, 2011, METHODS MOL BIOL, V711, P127, DOI 10.1007/978-1-61737-992-5_6 Jones DK, 2013, NEUROIMAGE, V73, P239, DOI 10.1016/j.neuroimage.2012.06.081 Jones DK, 2005, NEUROIMAGE, V26, P546, DOI 10.1016/j.neuroimage.2005.02.013 Jou RJ, 2011, AM J NEURORADIOL, V32, P1607, DOI 10.3174/ajnr.A2558 Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018 Leemans A., 2009, 17 ANN M INT SOC MAG, P3537 Pina-Camacho L, 2012, J AUTISM DEV DISORD, V42, P1326, DOI 10.1007/s10803-011-1360-4 Reijmer Y. D., 2012, PLOS ONE, V7 Schipul SE, 2011, FRONTIERS SYSTEMS NE, V5, P1, DOI DOI 10.3389/FNSYS.2011.00010 Schlegel AA, 2012, J COGNITIVE NEUROSCI, V24, P1664, DOI 10.1162/jocn_a_00240 Scholz J, 2009, NAT NEUROSCI, V12, P1370, DOI 10.1038/nn.2412 Shukla DK, 2011, NEUROPSYCHOLOGIA, V49, P1378, DOI 10.1016/j.neuropsychologia.2011.02.022 Shukla DK, 2011, J CHILD PSYCHOL PSYC, V52, P286, DOI 10.1111/j.1469-7610.2010.02342.x Smith SM, 2006, NEUROIMAGE, V31, P1487, DOI 10.1016/j.neuroimage.2006.02.024 Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099 Thomas C, 2011, CORTEX, V47, P863, DOI 10.1016/j.cortex.2010.07.006 Tournier JD, 2011, MAGN RESON MED, V65, P1532, DOI 10.1002/mrm.22924 Travers BG, 2012, AUTISM RES, V5, P289, DOI 10.1002/aur.1243 Van Hecke W, 2007, IEEE T MED IMAGING, V26, P1598, DOI 10.1109/TMI.2007.906786 Van Hecke W, 2011, NEUROIMAGE, V55, P566, DOI 10.1016/j.neuroimage.2010.12.005 Van Hecke W, 2010, HUM BRAIN MAPP, V31, P98, DOI 10.1002/hbm.20848 Van Hecke W, 2008, NEUROIMAGE, V43, P69, DOI 10.1016/j.neuroimage.2008.07.006 Verhoeven JS, 2012, CEREB CORTEX, V22, P2263, DOI 10.1093/cercor/bhr292 Vos SB, 2011, NEUROIMAGE, V55, P1566, DOI 10.1016/j.neuroimage.2011.01.048 Vos SB, 2012, NEUROIMAGE, V59, P2208, DOI 10.1016/j.neuroimage.2011.09.086 Wass S, 2011, BRAIN COGNITION, V75, P18, DOI 10.1016/j.bandc.2010.10.005 Wedeen VJ, 2012, SCIENCE, V335, P1628, DOI 10.1126/science.1215280 Westin CF, 2002, MED IMAGE ANAL, V6, P93, DOI 10.1016/S1361-8415(02)00053-1 Wiegell MR, 2000, RADIOLOGY, V217, P897 Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447 NR 57 TC 5 Z9 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2013 VL 6 IS 6 BP 642 EP 650 DI 10.1002/aur.1332 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 274PG UT WOS:000328617900018 PM 24089369 ER PT J AU McGrath, J Johnson, K O'Hanlon, E Garavan, H Gallagher, L Leemans, A AF McGrath, Jane Johnson, Katherine O'Hanlon, Erik Garavan, Hugh Gallagher, Louise Leemans, Alexander TI White Matter and Visuospatial Processing in Autism: A Constrained Spherical Deconvolution Tractography Study SO AUTISM RESEARCH LA English DT Article DE diffusion MRI; constrained spherical deconvolution; tractography; autism; visuospatial processing; inferior fronto-occipital fasciculus ID TENSOR IMAGING TRACTOGRAPHY; HIGH-FUNCTIONING AUTISM; DIFFUSION-WEIGHTED MRI; EMBEDDED FIGURES TASK; CORPUS-CALLOSUM; HUMAN BRAIN; CORTICAL UNDERCONNECTIVITY; HEMISPHERIC ASYMMETRIES; SPECTRUM DISORDERS; ARCUATE FASCICULUS AB Autism spectrum disorders (ASDs) are associated with a marked disturbance of neural functional connectivity, which may arise from disrupted organization of white matter. The aim of this study was to use constrained spherical deconvolution (CSD)-based tractography to isolate and characterize major intrahemispheric white matter tracts that are important in visuospatial processing. CSD-based tractography avoids a number of critical confounds that are associated with diffusion tensor tractography, and to our knowledge, this is the first time that this advanced diffusion tractography method has been used in autism research. Twenty-five participants with ASD and aged 25, intelligence quotient-matched controls completed a high angular resolution diffusion imaging scan. The inferior fronto-occipital fasciculus (IFOF) and arcuate fasciculus were isolated using CSD-based tractography. Quantitative diffusion measures of white matter microstructural organization were compared between groups and associated with visuospatial processing performance. Significant alteration of white matter organization was present in the right IFOF in individuals with ASD. In addition, poorer visuospatial processing was associated in individuals with ASD with disrupted white matter in the right IFOF. Using a novel, advanced tractography method to isolate major intrahemispheric white matter tracts in autism, this research has demonstrated that there are significant alterations in the microstructural organization of white matter in the right IFOF in ASD. This alteration was associated with poorer visuospatial processing performance in the ASD group. This study provides an insight into structural brain abnormalities that may influence atypical visuospatial processing in autism. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [McGrath, Jane; Johnson, Katherine; Gallagher, Louise] St James Hosp, Dept Psychiat, Trinity Ctr Hlth Sci, Dublin 8, Ireland. [Johnson, Katherine] Univ Melbourne, Parkville, Vic 3052, Australia. [O'Hanlon, Erik] Beaumont Hosp, Royal Coll Surg Ireland, Dept Psychiat, Dublin 9, Ireland. [Garavan, Hugh] Trinity Coll Dublin, Sch Psychol, Dublin, Ireland. [Garavan, Hugh] Trinity Coll Dublin, Inst Neurosci, Dublin, Ireland. [Garavan, Hugh] Univ Vermont, Dept Psychiat, Burlington, VT USA. [Garavan, Hugh] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA. [Leemans, Alexander] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands. RP McGrath, J (reprint author), St James Hosp, Dept Psychiat, Trinity Ctr Hlth Sci, Dublin 8, Ireland. EM jane.mcgrath@tcd.ie RI Leemans, Alexander/A-1784-2011 FU Molecular Medicine Ireland [4AA-G04005-0-S06] FX We wish to thank all the families who participated in this study, Mr. Sean Brennan and Dr. Miriam Law-Smith for help with recruitment, and Dr. Flavio Dell'Acqua, Dr. Marco Catani, Dr. Dara Cannon and Dr. Stephen Meredith for expert advice on setting up the study. We gratefully acknowledge the support of Molecular Medicine Ireland who funded this work (grant number 4AA-G04005-0-S06), and thank Mr. Brendan Behan, Mr. Sojo Joseph and many others for their invaluable assistance during the study. CR Alexander DC, 2002, MAGN RESON MED, V48, P331, DOI 10.1002/mrm.10209 BASSER PJ, 1994, BIOPHYS J, V66, P259 Behrens TEJ, 2007, NEUROIMAGE, V34, P144, DOI 10.1016/j.neuroimage.2006.09.018 Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072 Catani M, 2008, CORTEX, V44, P953, DOI 10.1016/j.cortex.2008.04.002 Catani M, 2008, CORTEX, V44, P1105, DOI 10.1016/j.cortex.2008.05.004 Catani M, 2008, NEUROIMAGE, V41, P1184, DOI 10.1016/j.neuroimage.2008.03.041 Chang LC, 2005, MAGNET RESON MED, V53, P1088, DOI 10.1002/mrm.20426 Conturo TE, 2008, J INT NEUROPSYCH SOC, V14, P933, DOI 10.1017/S1355617708081381 Damarla SR, 2010, AUTISM RES, V3, P273, DOI 10.1002/aur.153 Dell'Acqua F., 2012, HUMAN BRAIN IN PRESS, DOI 10.1002/hbm.22080 Doricchi F, 2008, CORTEX, V44, P983, DOI 10.1016/j.cortex.2008.03.006 Douaud G, 2011, NEUROIMAGE, V55, P880, DOI 10.1016/j.neuroimage.2010.12.008 Epelbaum S, 2008, CORTEX, V44, P962, DOI 10.1016/j.cortex.2008.05.003 Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083 Fox CJ, 2008, CORTEX, V44, P996, DOI 10.1016/j.cortex.2008.04.003 Frank LR, 2002, MAGNET RESON MED, V47, P1083, DOI 10.1002/mrm.10156 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Harms MB, 2010, NEUROPSYCHOL REV, V20, P290, DOI 10.1007/s11065-010-9138-6 Hong SS, 2011, PSYCHIAT RES-NEUROIM, V194, P333, DOI 10.1016/j.pscychresns.2011.03.009 Jeong JW, 2011, AM J NEURORADIOL, V32, P1600, DOI 10.3174/ajnr.A2557 Jeurissen B., 2012, HUMAN BRAIN IN PRESS, DOI 10.1002/hbm.22099 Jeurissen B, 2011, HUM BRAIN MAPP, V32, P461, DOI 10.1002/hbm.21032 Jones DK, 2010, NMR BIOMED, V23, P803, DOI 10.1002/nbm.1543 Jones DK, 2011, METHODS MOL BIOL, V711, P127, DOI 10.1007/978-1-61737-992-5_6 Jou RJ, 2011, AUST NZ J PSYCHIAT, V45, P153, DOI 10.3109/00048674.2010.534069 Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Klein S, 2010, IEEE T MED IMAGING, V29, P196, DOI 10.1109/TMI.2009.2035616 Kumar A, 2010, CEREB CORTEX, V20, P2103, DOI 10.1093/cercor/bhp278 Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018 Lee PS, 2007, NEUROIMAGE, V38, P184, DOI 10.1016/j.neuroimage.2007.07.013 Leemans A, 2009, MAGN RESON MED, V61, P1336, DOI 10.1002/mrm.21890 Leemans A, 2009, P 17 ANN M INT SOC M, P3536 Liu YN, 2011, NEUROPSYCHOLOGIA, V49, P2105, DOI 10.1016/j.neuropsychologia.2011.04.005 Lo YC, 2011, PSYCHIAT RES-NEUROIM, V192, P60, DOI 10.1016/j.pscychresns.2010.09.008 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Manjaly ZM, 2007, NEUROIMAGE, V35, P283, DOI 10.1016/j.neuroimage.2006.11.036 Martino J, 2010, CORTEX, V46, P691, DOI 10.1016/j.cortex.2009.07.015 McGrath J, 2012, AUTISM RES, V5, P314, DOI 10.1002/aur.1245 Metzler-Baddeley C, 2012, NEUROLOGY, V79, P2233, DOI 10.1212/WNL.0b013e31827689e8 Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069 Mori S, 2002, NMR BIOMED, V15, P468, DOI 10.1002/nbm.781 Mori S, 2002, MAGNET RESON MED, V47, P215, DOI 10.1002/mrm.10074 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Philippi CL, 2009, J NEUROSCI, V29, P15089, DOI 10.1523/JNEUROSCI.0796-09.2009 Pierpaoli C, 2001, NEUROIMAGE, V13, P1174, DOI 10.1006/nimg.2001.0765 Pluim JPW, 2003, IEEE T MED IMAGING, V22, P986, DOI 10.1109/TMI.2003.815867 Poustka L, 2011, WORLD J BIOL PSYCHIA, V13, P269 Pruessmann KP, 1999, MAGNET RESON MED, V42, P952, DOI 10.1002/(SICI)1522-2594(199911)42:5<952::AID-MRM16>3.3.CO;2-J Pugliese L, 2009, NEUROIMAGE, V47, P427, DOI 10.1016/j.neuroimage.2009.05.014 Raffelt D, 2012, NEUROIMAGE, V59, P3976, DOI 10.1016/j.neuroimage.2011.10.045 Reijmer Y. D., 2012, PLOS ONE, V7 Robertson LC, 2000, CURR DIR PSYCHOL SCI, V9, P59, DOI 10.1111/1467-8721.00061 Rudrauf D, 2008, CORTEX, V44, P1084, DOI 10.1016/j.cortex.2008.05.005 Sahyoun CP, 2010, NEUROPSYCHOLOGIA, V48, P86, DOI 10.1016/j.neuropsychologia.2009.08.013 Soulieres I, 2011, NEUROPSYCHOLOGIA, V49, P848, DOI 10.1016/j.neuropsychologia.2011.01.027 Thiebaut de Schotten M, 2008, CORTEX, V44, P1097, DOI 10.1016/j.cortex.2008.02.003 Thomas C, 2011, CORTEX, V47, P863, DOI 10.1016/j.cortex.2010.07.006 Tournier JD, 2007, NEUROIMAGE, V35, P1459, DOI 10.1016/j.neuroimage.2007.02.016 Tournier JD, 2004, NEUROIMAGE, V23, P1176, DOI 10.1016/j.neuroimage.2004.07.037 Tournier JD, 2011, MAGN RESON MED, V65, P1532, DOI 10.1002/mrm.22924 Tournier JD, 2008, NEUROIMAGE, V42, P617, DOI 10.1016/j.neuroimage.2008.05.002 Verhoeven J. S., 2011, CEREB CORTEX, V22, P2263 Vos SB, 2011, NEUROIMAGE, V55, P1566, DOI 10.1016/j.neuroimage.2011.01.048 Vos SB, 2012, NEUROIMAGE, V59, P2208, DOI 10.1016/j.neuroimage.2011.09.086 Wakana S, 2007, NEUROIMAGE, V36, P630, DOI 10.1016/j.neuroimage.2007.02.049 Wan CY, 2012, ANN NY ACAD SCI, V1252, P332, DOI 10.1111/j.1749-6632.2012.06446.x Wechsler D., 2004, WECHSLER INTELLIGENC Wechsler D., 1997, WAIS 3 ADM SCORING M Wedeen V. J., 2000, INT SOC MAGN RES MED Wedeen VJ, 2008, NEUROIMAGE, V41, P1267, DOI 10.1016/j.neuroimage.2008.03.036 Wedeen VJ, 2012, SCIENCE, V335, P1628, DOI 10.1126/science.1215280 Weinstein M, 2011, HUM BRAIN MAPP, V32, P534, DOI 10.1002/hbm.21042 Westin CF, 2002, MED IMAGE ANAL, V6, P93, DOI 10.1016/S1361-8415(02)00053-1 Wheeler-Kingshott CAM, 2009, MAGN RESON MED, V61, P1255, DOI 10.1002/mrm.21965 Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447 Yovel G, 2001, J EXP PSYCHOL HUMAN, V27, P1369, DOI 10.1037//0096-1523.27.6.1369 NR 79 TC 6 Z9 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 307 EP 319 DI 10.1002/aur.1290 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600001 PM 23509018 ER PT J AU Sterling, L Munson, J Estes, A Murias, M Webb, SJ King, B Dawson, G AF Sterling, Lindsey Munson, Jeffrey Estes, Annette Murias, Michael Webb, Sara Jane King, Bryan Dawson, Geraldine TI Fear-Potentiated Startle Response Is Unrelated to Social or Emotional Functioning in Adolescents With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; anxiety; startle response; amygdala ID PERVASIVE DEVELOPMENTAL DISORDERS; CEREBRAL-BLOOD-FLOW; ANXIETY DISORDERS; DIAGNOSTIC INTERVIEW; AMYGDALA DAMAGE; CHILDREN; SYMPTOMS; MONKEYS; STIMULI; INDIVIDUALS AB It has been suggested that atypical amygdala function contributes to the social impairments characteristic of autism spectrum disorders (ASDs). Previous research has demonstrated that adolescents and adults with ASD generate normal response during a fear-potentiated startle paradigm, suggesting this aspect of amygdala function is intact and may not account for the social dysfunction associated with the condition. The amygdala also plays a crucial role in the expression of anxiety and may contribute to high rates of reported anxiety in individuals with ASD. The present study partially replicates prior work by examining the fear-potentiated startle response in adolescents with ASD, and extends this to investigate the relationship between startle response and anxiety. Eyeblink magnitude and latency (electromyographic activity; EMG) were collected from 20 adolescents with ASD and 19 typically developing (TD) age-matched adolescents during a fear-potentiated startle paradigm. Parent-report and self-report of anxiety and additional psychiatric symptoms were collected. Parental reports indicated higher rates of associated psychopathology in adolescents with ASD compared with TD adolescents. Consistent with previous results, both groups showed normal potentiated startle response, and no group differences in EMG were found. Symptoms of anxiety and level of social impairment were unrelated to startle response. These findings held for all levels of anxiety, suggesting that within the context of the fear-potentiated startle paradigm, amygdala response is not associated with degree of atypical social or emotional functioning in ASD. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Sterling, Lindsey] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA. [Munson, Jeffrey; Estes, Annette; Murias, Michael; Webb, Sara Jane; King, Bryan] Univ Washington, Ctr Child Dev & Disabil, Seattle, WA 98195 USA. [Munson, Jeffrey; Murias, Michael; Webb, Sara Jane; King, Bryan] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Estes, Annette] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA. [Dawson, Geraldine] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA. [Dawson, Geraldine] Autism Speaks, New York, NY USA. RP Sterling, L (reprint author), Univ Calif Los Angeles, Semel Inst, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza,48-257, Los Angeles, CA 90095 USA. EM lsterling@mednet.ucla.edu FU UW Autism Center of Excellence [P50 HD055782]; Autism Speaks Predoctoral Fellowship (Sterling) FX Funding for this project was provided by the UW Autism Center of Excellence (P50 HD055782, King) and an Autism Speaks Predoctoral Fellowship (Sterling). CR ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213 Achenbach TM, 2001, MANUAL ASEBA SCH AGE Adolphs R, 1999, J COGNITIVE NEUROSCI, V11, P610, DOI 10.1162/089892999563670 Amaral DG, 2003, NOVART FDN SYMP, V251, P177 Amaral DG, 2003, GENES BRAIN BEHAV, V2, P295, DOI 10.1034/j.1601-183X.2003.00043.x American Psychiatric Association, 2000, DIAGN STAT MAN MENT [Anonymous], 2008, SURVEILLANCE SUMMARI, V38, P1 Bachevalier J, 1996, J AUTISM DEV DISORD, V26, P217, DOI 10.1007/BF02172015 Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7 Beck A. T., 1988, ANXIETY RES, V1, P23, DOI DOI 10.1080/10615808808248218 Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201 Bernier R, 2005, J AUTISM DEV DISORD, V35, P575, DOI 10.1007/s10803-005-0002-0 Berthoz S, 2005, EUR PSYCHIAT, V20, P291, DOI 10.1016/j.eurpsy.2004.06.013 Bishop SJ, 2007, TRENDS COGN SCI, V11, P307, DOI 10.1016/j.tics.2007.05.008 Broks P, 1998, NEUROPSYCHOLOGIA, V36, P59, DOI 10.1016/S0028-3932(97)00105-X Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27 Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 Coopens E., 2010, ACTA NEUROLOGICA BEL, V110, P36 Dalla C, 2009, PHYSIOL BEHAV, V97, P229, DOI 10.1016/j.physbeh.2009.02.035 Dawson M. E., 1999, STARTLE MODIFICATION, P6, DOI [10.1017/CBO9780511665523.003, DOI 10.1017/CB09780511665523.003] de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x Elliott C., 2007, DIFFERENTIAL ABILITY Emery NJ, 2001, BEHAV NEUROSCI, V115, P515, DOI 10.1037//0735-7044.115.3.515 Evans DW, 2005, CHILD PSYCHIAT HUM D, V36, P3, DOI 10.1007/s10578-004-3619-x Fredrikson M, 2003, ANN NY ACAD SCI, V985, P341 FRIDLUND AJ, 1986, PSYCHOPHYSIOLOGY, V23, P567, DOI 10.1111/j.1469-8986.1986.tb00676.x Gjevik E, 2011, J AUTISM DEV DISORD, V41, P761, DOI 10.1007/s10803-010-1095-7 Gresham F. M., 1990, SOCIAL SKILLS RATING Grillon C, 1997, J AM ACAD CHILD PSY, V36, P925, DOI 10.1097/00004583-199707000-00014 Grillon C, 1999, J ABNORM PSYCHOL, V108, P134, DOI 10.1037/0021-843X.108.1.134 GRILLON C, 1993, BIOL PSYCHIAT, V33, P566, DOI 10.1016/0006-3223(93)90094-T Grillon C, 1999, INT J PSYCHOPHYSIOL, V32, P63, DOI 10.1016/S0167-8760(99)00002-1 Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14 Juranek J, 2006, J CHILD NEUROL, V21, P1051, DOI 10.2310/7010.2006.00237 Kemper TL, 1998, J NEUROPATH EXP NEUR, V57, P645, DOI 10.1097/00005072-199807000-00001 Kessler RC, 2010, CURR TOP BEHAV NEURO, V2, P21, DOI 10.1007/7854_2009_9 Kim JJ, 2006, NEUROSCI BIOBEHAV R, V30, P188, DOI 10.1016/j.neubiorev.2005.06.005 Kluver H, 1939, ARCH NEURO PSYCHIATR, V42, P979 Kuusikko S, 2008, J AUTISM DEV DISORD, V38, P1697, DOI 10.1007/s10803-008-0555-9 LANG PJ, 1990, PSYCHOL REV, V97, P377, DOI 10.1037//0033-295X.97.3.377 Lang PJ, 2000, J AFFECT DISORDERS, V61, P137, DOI 10.1016/S0165-0327(00)00343-8 Liberzon I, 1999, BIOL PSYCHIAT, V45, P817, DOI 10.1016/S0006-3223(98)00246-7 Lissek S, 2008, AM J PSYCHIAT, V165, P124 Lopata C, 2010, J ABNORM CHILD PSYCH, V38, P765, DOI 10.1007/s10802-010-9406-1 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C., 2002, AUTISM DIAGNOSTIC OB Mazefsky CA, 2011, J PSYCHOPATHOL BEHAV, V33, P31, DOI 10.1007/s10862-010-9198-1 Mazurek MO, 2010, J AUTISM DEV DISORD, V40, P1512, DOI 10.1007/s10803-010-1014-y McPheeters ML, 2011, J AUTISM DEV DISORD, V41, P646, DOI 10.1007/s10803-010-1085-9 McTeague LM, 2009, BIOL PSYCHIAT, V65, P374, DOI 10.1016/j.biopsych.2008.09.023 Munson J, 2006, ARCH GEN PSYCHIAT, V63, P686, DOI 10.1001/archpsyc.63.6.686 Muris P., 1998, J ANXIETY DIORD, V12, P397 Newman JD, 1997, BRAIN RES, V758, P180, DOI 10.1016/S0006-8993(97)00212-6 Prather MD, 2001, NEUROSCIENCE, V106, P653, DOI 10.1016/S0306-4522(01)00445-6 Rauch SL, 2003, ANN NY ACAD SCI, V985, P389 Reaven JA, 2009, J SPEC PEDIATR NURS, V14, P192, DOI 10.1111/j.1744-6155.2009.00197.x Reeb-Sutherland BC, 2009, J AM ACAD CHILD PSY, V48, P610, DOI 10.1097/CHI.0b013e31819f70fb Reynolds CR, 1997, J ABNORM CHILD PSYCH, V25, P15, DOI 10.1023/A:1025751206600 Reynolds W. M., 1987, REYNOLDS ADOLESCENT Sabatinelli D, 2001, PSYCHOPHYSIOLOGY, V38, P719 Salmond CH, 2003, PHILOS T ROY SOC B, V358, P405, DOI 10.1098/rstb.2002.1210 Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004 Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006 Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007 Seltzer MM, 2004, MENT RETARD DEV D R, V10, P234, DOI 10.1002/mrdd.20038 Skokauskas N, 2010, PSYCHOPATHOLOGY, V43, P8, DOI 10.1159/000255958 Sparks BF, 2002, NEUROLOGY, V59, P184 Sparrow S, 1984, VINELAND ADAPTIVE BE Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9 Tillfors M, 2001, AM J PSYCHIAT, V158, P1220, DOI 10.1176/appi.ajp.158.8.1220 Uono S, 2011, SOC NEUROSCI-UK, V6, P452, DOI 10.1080/17470919.2011.605593 van Lang NDJ, 2006, BEHAV RES THER, V44, P849, DOI 10.1016/j.brat.2005.06.004 van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0 Waters AM, 2009, J ABNORM PSYCHOL, V118, P311, DOI 10.1037/a0015635 WEISKRANTZ L, 1956, J COMP PHYSIOL PSYCH, V49, P381 White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003 Wilensky AE, 2006, J NEUROSCI, V26, P12387, DOI 10.1523/JNEUROSCI.4316-06.2006 Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x NR 78 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 320 EP 331 DI 10.1002/aur.1289 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600002 PM 23495221 ER PT J AU Clark, AI Hughes, PS Grube, M Stewart, ME AF Clark, Andrea Irene Hughes, Paul Shane Grube, Manon Stewart, Mary Elizabeth TI Autistic Traits and Sensitivity to Interference With Flavour Identification SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; autistic traits; personality; multisensory perception; flavour perception ID SPECTRUM DISORDERS; FUNCTIONING AUTISM; ASPERGER-SYNDROME; CHILDREN; PERCEPTION; QUOTIENT; ADULTS; COLOR AB We assessed whether autistic traits are related to the ability to identify flavour. In general, the colour of the food or drink facilitates identification of its flavour. In the current study, the colour of drinks either provided congruent, incongruent or ambiguous (colourless) information about the flavour. Participants identified the flavours of 12 drinks from a list and completed a measure of autistic traits, the Autism-Spectrum Quotient (AQ). In line with previous studies, flavour identification was impaired in incongruent conditions, while identification in congruent conditions was not improved when compared with that in ambiguous conditions. AQ scores were related to flavour identification in incongruent conditions, in that as the AQ score increased, accuracy of flavour identification decreased. There were no relationships found in the congruent or ambiguous conditions. This finding is in line with the idea that conflicting sensory information may be more disruptive for individuals on the autism spectrum. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Clark, Andrea Irene; Hughes, Paul Shane; Stewart, Mary Elizabeth] Heriot Watt Univ, Edinburgh EH14 4AS, Midlothian, Scotland. [Grube, Manon] Newcastle Univ, Sch Med, Inst Neurosci, Auditory Grp, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. RP Stewart, ME (reprint author), Heriot Watt Univ, Edinburgh EH14 4AS, Midlothian, Scotland. EM m.e.stewart@hw.ac.uk CR Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643 Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x Cohen J., 1988, STAT POWER ANAL BEHA, V2nd Delwiche J, 2004, FOOD QUAL PREFER, V15, P137, DOI 10.1016/S0950-3293(03)00041-7 Foss-Feig JH, 2010, EXP BRAIN RES, V203, P381, DOI 10.1007/s00221-010-2240-4 FRANK RA, 1989, CHEM SENSES, V14, P371, DOI 10.1093/chemse/14.3.371 Fugard AJB, 2011, AUTISM, V15, P327, DOI 10.1177/1362361310371798 Gepner B, 2002, J AUTISM DEV DISORD, V32, P231, DOI 10.1023/A:1015410015859 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Hochhauser M, 2010, RES AUTISM SPECT DIS, V4, P746, DOI 10.1016/j.rasd.2010.01.015 Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372 Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x Russo N, 2010, AUTISM RES, V3, P253, DOI 10.1002/aur.152 Stewart M. E., 2011, MCGILL J MED, V12, P108 Stewart ME, 2009, AUTISM, V13, P133, DOI 10.1177/1362361308098515 Tavassoli T, 2012, J AUTISM DEV DISORD, V42, P1419, DOI 10.1007/s10803-011-1377-8 Wang AT, 2006, BRAIN, V129, P932, DOI 10.1093/brain/awl032 Zampini M, 2007, FOOD QUAL PREFER, V18, P975, DOI 10.1016/j.foodqual.2007.04.001 NR 21 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 332 EP 336 DI 10.1002/aur.1293 PG 5 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600003 PM 23576375 ER PT J AU Reynolds, S Urruela, M Devine, DP AF Reynolds, Stacey Urruela, Meagan Devine, Darragh P. TI Effects of Environmental Enrichment on Repetitive Behaviors in the BTBR T plus tf/J Mouse Model of Autism SO AUTISM RESEARCH LA English DT Article DE autism; BTBR inbred strain; environmental enrichment; mouse model; repetitive behavior; stereotypy ID SPECTRUM DISORDERS; STEREOTYPED BEHAVIOR; MICE; CHILDREN; PHENOTYPES; INTERESTS; RELEVANT; SYMPTOMS; DEFICITS; MEMORY AB Lower order and higher order repetitive behaviors have been documented in the BTBR T+tf/J (BTBR) mouse strain, a mouse model that exhibits all three core behavioral domains that define autism. The purpose of this study was to evaluate the effectiveness of environmental enrichment for reducing repetitive behaviors in BTBR mice. Lower order behaviors were captured by assaying the time and sequence of grooming, while higher order behaviors were measured using pattern analysis of an object exploration task from digital recordings. Baseline scores were established at 7 weeks of age, followed by 30 days of housing in either a standard or enriched cage. As expected, BTBR mice spent significantly more time grooming and had a more rigid grooming sequence than control C57BL/6J mice did at baseline. After 30 days of enrichment housing, BTBR mice demonstrated a significant reduction in time spent grooming, resulting in levels that were lower than those exhibited by BTBR mice in standard housing. However, no changes were noted in the rigidity of their grooming sequence. In contrast to previous findings, there was no difference in repetitive patterns of exploration at baseline between BTBR and C57BL/6J mice in the object exploration test. Subsequently, enrichment did not significantly alter the number of repetitive patterns at posttest. Overall, the results suggest that environmental enrichment may be beneficial for reducing the time spent engaging in lower order repetitive behaviors, but may not change the overall quality of the behaviors when they do manifest. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Reynolds, Stacey] Virginia Commonwealth Univ, Richmond, VA 23298 USA. [Urruela, Meagan; Devine, Darragh P.] Univ Florida, Gainesville, FL USA. RP Reynolds, S (reprint author), Virginia Commonwealth Univ, Box 980008, Richmond, VA 23298 USA. EM reynoldsse3@vcu.edu FU National Center for Medical Rehabilitation Research; National Institute of Neurological Disorders and Stroke, Rehabilitation Research Career Development Program [K12 HD055929] FX Grant Sponsor: National Center for Medical Rehabilitation Research and the National Institute of Neurological Disorders and Stroke, Rehabilitation Research Career Development Program.Grant Number: K12 HD055929. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Baranek GT, 2002, J AUTISM DEV DISORD, V32, P397, DOI 10.1023/A:1020541906063 Boyd BA, 2011, J AUTISM DEV DISORD, V41, P1330, DOI 10.1007/s10803-010-1156-y Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P57, DOI 10.1007/s10803-008-0599-x FAVELL JE, 1982, ANAL INTERVEN DEVEL, V2, P83, DOI 10.1016/0270-4684(82)90007-6 Kalueff AV, 2007, NAT PROTOC, V2, P2538, DOI 10.1038/nprot.2007.367 Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x Lewis MH, 2007, BEHAV BRAIN RES, V176, P66, DOI 10.1016/j.bbr.2006.08.023 Lipina TV, 2013, NEUROPHARMACOLOGY, V64, P283, DOI 10.1016/j.neuropharm.2012.06.054 MacPherson P, 2008, BRAIN RES, V1210, P179, DOI 10.1016/j.brainres.2008.03.008 Martinez-Cue C, 2002, BEHAV BRAIN RES, V134, P185, DOI 10.1016/S0166-4328(02)00026-8 McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x Militerni R, 2002, EUR CHILD ADOLES PSY, V11, P210, DOI 10.1007/s00787-002-0279-x Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030 Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029 Pearson BL, 2011, GENES BRAIN BEHAV, V10, P228, DOI 10.1111/j.1601-183X.2010.00659.x Reynolds S, 2010, J NEURODEV DISORD, V2, P120, DOI 10.1007/s11689-010-9053-4 Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265 Richman DM, 2005, AM J MENT RETARD, V110, P439, DOI 10.1352/0895-8017(2005)110[439:LAOSPA]2.0.CO;2 Ryan BC, 2010, BEHAV BRAIN RES, V208, P178, DOI 10.1016/j.bbr.2009.11.031 Sigafoos J, 1996, BEHAV MODIF, V20, P60, DOI 10.1177/01454455960201003 Smith SA, 2005, AM J OCCUP THER, V59, P418 Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x Tanimura Y, 2008, BEHAV BRAIN RES, V189, P250, DOI 10.1016/j.bbr.2008.01.001 Turner CA, 2002, BRAIN RES, V938, P15, DOI 10.1016/S0006-8993(02)02472-1 Turner CA, 2003, PHYSIOL BEHAV, V80, P259, DOI 10.1016/j.physbeh.2003.07.008 Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104 Wink LK, 2010, CURR TREAT OPTION NE, V12, P529, DOI 10.1007/s11940-010-0091-8 Yang M, 2011, AUTISM RES, V4, P17, DOI 10.1002/aur.163 NR 30 TC 4 Z9 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 337 EP 343 DI 10.1002/aur.1298 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600004 PM 23813950 ER PT J AU Lukose, R Brown, K Barber, CM Kulesza, RJ AF Lukose, Richard Brown, Kevin Barber, Carol M. Kulesza, Randy Joseph, Jr. TI Quantification of the Stapedial Reflex Reveals Delayed Responses in Autism SO AUTISM RESEARCH LA English DT Article DE autistic; auditory; superior olive; facial nucleus ID BRAIN-STEM RESPONSES; CEREBELLAR PURKINJE-CELLS; TEST-RETEST RELIABILITY; MESSENGER-RNA LEVELS; SPECTRUM DISORDERS; INFANTILE-AUTISM; NEURONAL ORGANIZATION; MULTIPLE-SCLEROSIS; SUPERIOR OLIVE; MUSCLE-REFLEX AB Autism is a developmental disorder characterized, in part, by sensory abnormalities. It is well established that most if not all patients with autism have problems with auditory processing, ranging from deafness to hyperacusis, and physiological testing of auditory function (i.e. auditory brain stem responses) implicates brain stem dysfunction in autism. Additionally, previous research from this lab has revealed significantly fewer auditory brain stem neurons in autistic subjects as young as 2 years of age. These observations have led us to hypothesize that objective, noninvasive measures of auditory function can be used as an early screening tool to identify neonates with an elevated risk of carrying a diagnosis of autism. Here, we provide a detailed quantitative investigation of the acoustic stapedial reflex (ASR), a three- or four-neuron brain stem circuit, in young autistic subjects and normal developing controls. Indeed, we find significantly lower thresholds, responses occurring at significantly longer latency and right-left asymmetry in autistic subjects. The results from this investigation support deficits in auditory function as a cardinal feature of autism and suggest that individuals with autism can be identified by their ASR responses. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Lukose, Richard] Univ Pittsburgh, Dept Neurol, Med Ctr Hamot, Erie, PA USA. [Brown, Kevin; Kulesza, Randy Joseph, Jr.] Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA 16509 USA. [Barber, Carol M.] Carolina Pediat Therapy, Asheville, NC USA. RP Kulesza, RJ (reprint author), Lake Erie Coll Osteopath Med, Auditory Res Ctr, Erie, PA 16509 USA. EM rkulesza@lecom.edu FU Lake Erie Consortium of Osteopathic Medical Training FX Grant sponsor: Lake Erie Consortium of Osteopathic Medical Training. CR Alcantara JI, 2004, J CHILD PSYCHOL PSYC, V45, P1107, DOI 10.1111/j.1469-7610.2004.t01-1-00303.x Allen DA, 1988, J CHILD NEUROLOGY S, V3, P48 Altschuler R. A., 2010, OXFORD HDB AUDITORY, P65 ARIN D M, 1991, Neurology, V41, P307 BAUMAN M, 1985, NEUROLOGY, V35, P866 Billig I, 2007, BRAIN RES, V1154, P124, DOI 10.1016/j.brainres.2007.04.007 Bolton PF, 2012, J AM ACAD CHILD PSY, V51, P249, DOI 10.1016/j.jaac.2011.12.009 BORG E, 1973, BRAIN RES, V49, P101, DOI 10.1016/0006-8993(73)90404-6 Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582 COHEN M, 1988, SCAND AUDIOL, V17, P153, DOI 10.3109/01050398809042187 COURVILL.J, 1966, J COMP NEUROL, V126, P471, DOI 10.1002/cne.901260309 Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0 Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7 Feeney M Patrick, 2005, J Am Acad Audiol, V16, P278 GAFFNEY GR, 1988, BIOL PSYCHIAT, V24, P578, DOI 10.1016/0006-3223(88)90168-0 GEDDES NK, 1987, INT J PEDIATR OTORHI, V13, P293, DOI 10.1016/0165-5876(87)90110-8 GILLBERG C, 1983, J AUTISM DEV DISORD, V13, P181, DOI 10.1007/BF01531818 Gomes Erissandra, 2008, Pro Fono, V20, P279 Gomes E, 2004, ARQ NEURO-PSIQUIAT, V62, P797, DOI 10.1590/S0004-282X2004000500011 Gravel JS, 2006, EAR HEARING, V27, P299, DOI 10.1097/01.aud.0000215979.65645.22 Greenspan S. I., 1997, J DEV LEARNING DISOR, V1, P87 GREISEN O, 1970, ACTA OTO-LARYNGOL, V70, P366 Grindle CF, 2012, BEHAV MODIF, V36, P298, DOI 10.1177/0145445512441199 GUINAN JJ, 1989, J COMP NEUROL, V287, P134, DOI 10.1002/cne.902870110 HALL JW, 1982, EAR HEARING, V3, P296, DOI 10.1097/00003446-198211000-00002 HASHIMOTO T, 1993, J CHILD NEUROL, V8, P149 HESS K, 1979, J NEUROL NEUROSUR PS, V42, P331, DOI 10.1136/jnnp.42.4.331 HIRSCH A, 1983, AUDIOLOGY, V22, P463 JERGER S, 1977, ARCH OTOLARYNGOL, V103, P445 KAU RJ, 1987, LARYNGO RHINO OTOL, V66, P631, DOI 10.1055/s-2007-997148 Kei J, 2012, J AM ACAD AUDIOL, V23, P46, DOI 10.3766/jaaa.23.1.5 Kellerman GR, 2005, CNS SPECTRUMS, V10, P748 Khalfa S, 2001, EUR J NEUROSCI, V13, P628, DOI 10.1046/j.1460-9568.2001.01423.x Khalfa S, 2004, HEARING RES, V198, P87, DOI 10.1016/j.heares.2004.07.006 KLIN A, 1993, J AUTISM DEV DISORD, V23, P15, DOI 10.1007/BF01066416 Kulesza R. J., 2009, BRAIN RES, V1200, P132 Kulesza RJ, 2008, BRAIN RES, V1200, P132, DOI 10.1016/j.brainres.2008.01.009 Kulesza RJ, 2008, HEARING RES, V241, P52, DOI 10.1016/j.heares.2008.04.010 Kulesza RJ, 2011, BRAIN RES, V1367, P360, DOI 10.1016/j.brainres.2010.10.015 Kwon S, 2007, J KOREAN MED SCI, V22, P656 Lepisto T, 2005, BRAIN RES, V1066, P147, DOI 10.1016/j.brainres.2005.10.052 Malmierca M. S., 2004, RAT NERVOUS SYSTEM, P996 MATTLE H, 1986, J NEUROL, V233, P90, DOI 10.1007/BF00313853 Maziade M, 2000, ARCH GEN PSYCHIAT, V57, P1077, DOI 10.1001/archpsyc.57.11.1077 Mazlan R, 2007, INT J AUDIOL, V46, P711, DOI 10.1080/14992020701525858 Mazlan R, 2009, EAR HEARING, V30, P295, DOI 10.1097/AUD.0b013e31819c3ea0 MCCLELLAND RJ, 1992, BRIT J PSYCHIAT, V160, P659, DOI 10.1192/bjp.160.5.659 MMWR Surveillance Summary, 2012, PREV AUT SPECTR DIS, V61, P1 Mukerji S, 2010, TRENDS AMPLIF, V14, P170, DOI 10.1177/1084713810381771 Oblak AL, 2011, BRAIN RES, V1380, P218, DOI 10.1016/j.brainres.2010.09.021 OSTERHAMMEL D, 1979, Scandinavian Audiology, V8, P153, DOI 10.3109/01050397909076316 OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225 Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287 PIVEN J, 1992, BIOL PSYCHIAT, V31, P491, DOI 10.1016/0006-3223(92)90260-7 RASMUSSEN GL, 1946, J COMP NEUROL, V84, P141, DOI 10.1002/cne.900840204 Raymond G., 1989, ACTA NEUROPATHOL, V91, P117 Remington B, 2007, AM J MENT RETARD, V112, P418, DOI 10.1352/0895-8017(2007)112[418:EIBIOF]2.0.CO;2 RITVO ER, 1986, AM J PSYCHIAT, V143, P862 ROBIER A, 1984, AUDIOLOGY, V23, P490 Rodier PM, 1996, J COMP NEUROL, V370, P247, DOI 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2 Roper L, 2003, AUTISM, V7, P245, DOI 10.1177/1362361303007003002 Rosenhall U, 2003, EAR HEARING, V24, P206, DOI 10.1097/01.AUD.0000069326.11466.7E Rosenhall U, 1999, J AUTISM DEV DISORD, V29, P349, DOI 10.1023/A:1023022709710 Roth DAE, 2012, DEV MED CHILD NEUROL, V54, P23, DOI 10.1111/j.1469-8749.2011.04149.x ROUILLER EM, 1989, BRAIN RES, V476, P21, DOI 10.1016/0006-8993(89)91532-1 RUMSEY JM, 1984, BIOL PSYCHIAT, V19, P1403 Russo N, 2009, DEVELOPMENTAL SCI, V12, P557, DOI 10.1111/j.1467-7687.2008.00790.x Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006 SKOFF BF, 1980, PSYCHIAT RES, V2, P157, DOI 10.1016/0165-1781(80)90072-4 SURIA D, 1975, FOLIA PHONIATR, V27, P387 Szelag E, 2004, BRIT J PSYCHOL, V95, P269, DOI 10.1348/0007126041528167 Teder-Salejarvi WA, 2005, COGNITIVE BRAIN RES, V23, P221, DOI 10.1016/j.cogbrainres.2004.10.021 Tharpe AM, 2006, EAR HEARING, V27, P430, DOI 10.1097/01.aud.0000224981.60575.d8 THOMPSON GC, 1985, J COMP NEUROL, V231, P270, DOI 10.1002/cne.902310214 Tomchek SD, 2007, AM J OCCUP THER, V61, P190 Valenti Marco, 2010, Child Adolesc Psychiatry Ment Health, V4, P23, DOI 10.1186/1753-2000-4-23 Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4 Whitney ER, 2008, CEREBELLUM, V7, P406, DOI 10.1007/s12311-008-0043-y Wing L, 1997, LANCET, V350, P1761, DOI 10.1016/S0140-6736(97)09218-0 Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3 Yip J, 2009, AUTISM RES, V2, P50, DOI 10.1002/aur.62 Zikopoulos B, 2010, J NEUROSCI, V30, P14595, DOI 10.1523/JNEUROSCI.2257-10.2010 NR 82 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 344 EP 353 DI 10.1002/aur.1297 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600005 PM 23825093 ER PT J AU Griesi-Oliveira, K Sunaga, DY Alvizi, L Vadasz, E Passos-Bueno, MR AF Griesi-Oliveira, Karina Sunaga, Daniele Yumi Alvizi, Lucas Vadasz, Estevao Passos-Bueno, Maria Rita TI Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE expression studies; androgen signaling; CHD8; stem cells of human exfoliated deciduous teeth ID DE-NOVO MUTATIONS; COPY NUMBER VARIANTS; EXPRESSION; GENES; LINES; GENETICS; POWERFUL; CHILDREN; PATHWAYS; BRAIN AB Identification of the causes of autism spectrum disorders (ASDs) is hampered by their genetic heterogeneity; however, the different genetic alterations leading to ASD seem to be implicated in the disturbance of common molecular pathways or biological processes. In this scenario, the search for differentially expressed genes (DEGs) between ASD patients and controls is a good alternative to identify the molecular etiology of such disorders. Here, we employed genome-wide expression analysis to compare the transcriptome of stem cells of human exfoliated deciduous teeth (SHEDs) of idiopathic autistic patients (n=7) and control samples (n=6). Nearly half of the 683 identified DEGs are expressed in the brain (P=0.003), and a significant number of them are involved in mechanisms previously associated with ASD such as protein synthesis, cytoskeleton regulation, cellular adhesion and alternative splicing, which validate the use of SHEDs to disentangle the causes of autism. Autistic patients also presented overexpression of genes regulated by androgen receptor (AR), and AR itself, which in turn interacts with CHD8 (chromodomain helicase DNA binding protein 8), a gene recently shown to be associated with the cause of autism and found to be upregulated in some patients tested here. These data provide a rationale for the mechanisms through which CHD8 leads to these diseases. In summary, our results suggest that ASD share deregulated pathways and revealed that SHEDs represent an alternative cell source to be used in the understanding of the biological mechanisms involved in the etiology of ASD. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Griesi-Oliveira, Karina; Sunaga, Daniele Yumi; Alvizi, Lucas; Passos-Bueno, Maria Rita] Univ Sao Paulo, Ctr Estudos Genoma Humano, Dept Biol, Inst Biociencias, BR-05508090 Sao Paulo, Brazil. [Vadasz, Estevao] Univ Sao Paulo, Fac Med, Inst Psiquiatria, Hosp Clin, BR-05508090 Sao Paulo, Brazil. RP Passos-Bueno, MR (reprint author), Univ Sao Paulo, Inst Biociencias, Rua Matao,277,Sala 200, BR-05508090 Sao Paulo, Brazil. EM passos@ib.usp.br FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho nacional de desenvolvimento cientifico e tecnologico (CNPq) FX This study was supported by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) and Conselho nacional de desenvolvimento cientifico e tecnologico (CNPq). We would like to thank Daniela Franco Bueno and Gerson Shigeru Kobayshi for the control microarray data. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Anitha A, 2008, AM J MED GENET B, V147B, P1019, DOI 10.1002/ajmg.b.30697 Baron CA, 2006, J AUTISM DEV DISORD, V36, P973, DOI 10.1007/s10803-006-0134-x Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455 BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289 Betancur C, 2009, TRENDS NEUROSCI, V32, P402, DOI 10.1016/j.tins.2009.04.003 Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078 Breitling R, 2004, FEBS LETT, V573, P83, DOI 10.1016/j.febslet.2004.07.055 Bueno DF, 2011, STEM CELL REV REP, V7, P446, DOI 10.1007/s12015-010-9197-3 Buyske S., 2006, BMC GENET, V10, P8 Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180 Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27 Chahrour M. H., 2012, PLOS GENETICS, V8 Choi J, 2012, HUM MOL GENET, V21, P1566, DOI 10.1093/hmg/ddr594 Costa AD, 2008, J CRANIOFAC SURG, V19, P204 Cusco I, 2009, HUM MOL GENET, V18, P1795, DOI 10.1093/hmg/ddp092 d'Aquino R, 2009, J EXP ZOOL PART B, V312B, P408, DOI 10.1002/jez.b.21263 El-Fishawy P, 2010, PSYCHIAT CLIN N AM, V33, P83, DOI 10.1016/j.psc.2009.12.002 Gkogkas CG, 2013, NATURE, V493, P371, DOI 10.1038/nature11628 Gregg JP, 2008, GENOMICS, V91, P22, DOI 10.1016/j.ygeno.2007.09.003 Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118 Hu VW, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005775 Hu VW, 2009, AUTISM RES, V2, P78, DOI 10.1002/aur.73 Iossifov I, 2012, NEURON, V74, P285, DOI 10.1016/j.neuron.2012.04.009 Irizarry RA, 2003, BIOSTATISTICS, V4, P249, DOI 10.1093/biostatistics/4.2.249 Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017 Levy D, 2011, NEURON, V70, P886, DOI 10.1016/j.neuron.2011.05.015 Melin M, 2006, NEUROPSYCHOBIOLOGY, V54, P64, DOI 10.1159/000096040 Menon T, 2010, MOL ENDOCRINOL, V24, P1165, DOI 10.1210/me.2009-0421 Miura M, 2003, P NATL ACAD SCI USA, V100, P5807, DOI 10.1073/pnas.0937635100 Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657 Neale BM, 2012, NATURE, V485, P242, DOI 10.1038/nature11011 Neves-Pereira M, 2009, J MED GENET, V46, P759, DOI 10.1136/jmg.2009.066852 Nishimura Y, 2007, HUM MOL GENET, V16, P1682, DOI 10.1093/hmg/ddm116 Orabona GM, 2009, BRAIN RES, V1250, P14, DOI 10.1016/j.brainres.2008.11.007 O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989 O'Roak BJ, 2012, SCIENCE, V338, P1619, DOI 10.1126/science.1227764 O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835 Raj A, 2010, NATURE, V463, P913, DOI 10.1038/nature08781 Russo A J, 2009, Biomark Insights, V4, P181 Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945 Sarachana T, 2010, GENOME MED, V2, DOI 10.1186/gm144 Sbacchi S, 2010, CURR GENOMICS, V11, P136, DOI 10.2174/138920210790886880 Seno M. M. G., 2010, BRAIN RES, V1380, P85 Smith Ryan M, 2011, Front Synaptic Neurosci, V3, P1, DOI 10.3389/fnsyn.2011.00001 Sousa I, 2009, EUR J HUM GENET, V17, P749, DOI 10.1038/ejhg.2008.215 Sugihara G, 2007, PROG NEURO-PSYCHOPH, V31, P412, DOI 10.1016/j.pnpbp.2006.10.010 Talebizadeh Z, 2006, J MED GENET, V43, DOI 10.1136/jmg.2005.036897 Talkowski ME, 2012, CELL, V149, DOI 10.1016/j.cell.2012.03.028 Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110 von Heydebreck A., 2004, BIOCONDUCTOR PROJECT Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145 Yochum CL, 2010, BEHAV BRAIN RES, V210, P202, DOI 10.1016/j.bbr.2010.02.032 NR 54 TC 5 Z9 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 354 EP 361 DI 10.1002/aur.1296 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600006 PM 23801657 ER PT J AU Scheeren, AM Koot, HM Mundy, PC Mous, L Begeer, S AF Scheeren, Anke M. Koot, Hans M. Mundy, Peter C. Mous, Larissa Begeer, Sander TI Empathic Responsiveness of Children and Adolescents with High-Functioning Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; empathy; emotional response; social interaction ID YOUNG-CHILDREN; RESPONSES; DISTRESS; OTHERS; COGNITION; EMOTIONS; CONTEXT; RISK AB Previous studies have shown reduced empathic responsiveness to others' emotions in preschoolers with autism spectrum disorder (ASD) and an intellectual disability. However, age and intelligence may promote children's empathic responsiveness. Therefore, we examined the empathic responsiveness in normally intelligent school-aged children and adolescents with a clinical diagnosis of ASD (n=151) and in a typically developing comparison group (n=50), using structured observations and parent reports. Based on the observations, participants' responses to the emotional displays of an interviewer were surprisingly similar. However, compared with parents from the comparison group, parents of a child with ASD reported significantly fewer empathic responses, particularly when the child received a high score on the Autism Diagnostic Observation Schedule. Even though parents report a reduced empathic responsiveness in school-aged children and adolescents with ASD, it may be difficult to find these empathic limitations during brief observations in a structured setting. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Scheeren, Anke M.; Koot, Hans M.; Mous, Larissa; Begeer, Sander] Vrije Univ Amsterdam, NL-1081 BT Amsterdam, Netherlands. [Scheeren, Anke M.; Koot, Hans M.; Mous, Larissa; Begeer, Sander] Autism Res Amsterdam, Amsterdam, Netherlands. [Mundy, Peter C.] Univ Calif Davis, Sch Educ, MIND Inst, Davis, CA 95616 USA. [Begeer, Sander] Univ Sydney, Sydney, NSW 2006, Australia. RP Scheeren, AM (reprint author), Vrije Univ Amsterdam, Dept Dev Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands. EM a.m.scheeren@vu.nl FU Stichting Nuts Ohra [SNO-T-0701-116] FX Grant sponsor: Stichting Nuts Ohra.Grant number: SNO-T-0701-116. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Bacon AL, 1998, J AUTISM DEV DISORD, V28, P129, DOI 10.1023/A:1026040615628 Bandstra NF, 2011, PAIN, V152, P1074, DOI 10.1016/j.pain.2011.01.024 Bastiaansen JA, 2011, J AUTISM DEV DISORD, V41, P1256, DOI 10.1007/s10803-010-1157-x Begeer S, 2008, DEV REV, V28, P342, DOI 10.1016/j.dr.2007.09.001 CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x Constantino J. N., 2007, SOCIAL RESPONSIVENES Corona R, 1998, CHILD DEV, V69, P1494, DOI 10.1111/j.1467-8624.1998.tb06172.x Decety J, 2008, DEV PSYCHOPATHOL, V20, P1053, DOI 10.1017/S0954579408000503 de Waal FBM, 2008, ANNU REV PSYCHOL, V59, P279, DOI 10.1146/annurev.psych.59.103006.093625 Dirks MA, 2010, J CHILD PSYCHOL PSYC, V51, P1040, DOI 10.1111/j.1469-7610.2010.02244.x Dissanayake C, 1996, J CHILD PSYCHOL PSYC, V37, P461, DOI 10.1111/j.1469-7610.1996.tb01427.x Downs A, 2004, J AUTISM DEV DISORD, V34, P625, DOI 10.1007/s10803-004-5284-0 Dunn LM, 2004, PEABODY PICTURE VOCA Dziobek I, 2008, J AUTISM DEV DISORD, V38, P464, DOI 10.1007/s10803-007-0486-x GILLBERG CL, 1992, J CHILD PSYCHOL PSYC, V33, P813, DOI 10.1111/j.1469-7610.1992.tb01959.x Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7 Hillier A, 2002, J AUTISM DEV DISORD, V32, P583, DOI 10.1023/A:1021259115185 Hobson JA, 2009, DEVELOPMENTAL SCI, V12, P249, DOI 10.1111/j.1467-7687.2008.00762.x Hodapp AF, 1999, PSYCHOL REP, V84, P1139, DOI 10.2466/PR0.84.3.1139-1142 Hudry K, 2009, RES AUTISM SPECT DIS, V3, P74, DOI 10.1016/j.rasd.2008.04.004 Hutman T, 2010, J CHILD PSYCHOL PSYC, V51, P1010, DOI 10.1111/j.1469-7610.2010.02270.x Johnson SA, 2009, J AUTISM DEV DISORD, V39, P1706, DOI 10.1007/s10803-009-0809-1 Jones AP, 2010, J CHILD PSYCHOL PSYC, V51, P1188, DOI 10.1111/j.1469-7610.2010.02280.x Kasari C, 2011, J AUTISM DEV DISORD, V41, P533, DOI 10.1007/s10803-010-1076-x Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 LOVELAND KA, 1991, J AUTISM DEV DISORD, V21, P177, DOI 10.1007/BF02284758 Macintosh Kathleen, 2006, Autism, V10, P199, DOI 10.1177/1362361306062026 McDonald NM, 2012, J AUTISM DEV DISORD, V42, P1566, DOI 10.1007/s10803-011-1390-y McGovern CW, 2005, J CHILD PSYCHOL PSYC, V46, P401, DOI 10.1111/j.1469-7610.2004.00361.x Preston SD, 2002, BEHAV BRAIN SCI, V25, P1 Saarni C, 2001, SOC DEV, V10, P125, DOI 10.1111/1467-9507.00152 Scambler DJ, 2007, J AUTISM DEV DISORD, V37, P553, DOI 10.1007/s10803-006-0186-y Scheeren AM, 2013, J CHILD PSYCHOL PSYC, V54, P628, DOI 10.1111/jcpp.12007 Scheeren AM, 2012, J AUTISM DEV DISORD, V42, P2046, DOI 10.1007/s10803-012-1451-x Schwenck C, 2012, J CHILD PSYCHOL PSYC, V53, P651, DOI 10.1111/j.1469-7610.2011.02499.x SIGMAN MD, 1992, CHILD DEV, V63, P796, DOI 10.1111/j.1467-8624.1992.tb01662.x VERHULST FC, 1994, J ABNORM CHILD PSYCH, V22, P531, DOI 10.1007/BF02168936 Yirmiya N, 1998, PSYCHOL BULL, V124, P283, DOI 10.1037/0033-2909.124.3.283 YIRMIYA N, 1992, CHILD DEV, V63, P150, DOI 10.1111/j.1467-8624.1992.tb03603.x ZAHNWAXLER C, 1992, DEV PSYCHOL, V28, P126, DOI 10.1037/0012-1649.28.1.126 NR 41 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 362 EP 371 DI 10.1002/aur.1299 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600007 PM 24039228 ER PT J AU van Santen, JPH Sproat, RW Hill, AP AF van Santen, Jan P. H. Sproat, Richard W. Hill, Alison Presmanes TI Quantifying Repetitive Speech in Autism Spectrum Disorders and Language Impairment SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; specific language impairment; echolalia; repetitive behavior ID DIAGNOSTIC OBSERVATION SCHEDULE; FRAGILE-X-SYNDROME; IMMEDIATE ECHOLALIA; MENTAL-RETARDATION; YOUNG-CHILDREN; DOWN-SYNDROME; FIELD TRIAL; STEREOTYPY; INTERVIEW; BEHAVIOR AB We report on an automatic technique for quantifying two types of repetitive speech: repetitions of what the child says him/herself (self-repeats) and of what is uttered by an interlocutor (echolalia). We apply this technique to a sample of 111 children between the ages of four and eight: 42 typically developing children (TD), 19 children with specific language impairment (SLI), 25 children with autism spectrum disorders (ASD) plus language impairment (ALI), and 25 children with ASD with normal, non-impaired language (ALN). The results indicate robust differences in echolalia between the TD and ASD groups as a whole (ALN+ALI), and between TD and ALN children. There were no significant differences between ALI and SLI children for echolalia or self-repetitions. The results confirm previous findings that children with ASD repeat the language of others more than other populations of children. On the other hand, self-repetition does not appear to be significantly more frequent in ASD, nor does it matter whether the child's echolalia occurred within one (immediate) or two turns (near-immediate) of the adult's original utterance. Furthermore, non-significant differences between ALN and SLI, between TD and SLI, and between ALI and TD are suggestive that echolalia may not be specific to ALN or to ASD in general. One important innovation of this work is an objective fully automatic technique for assessing the amount of repetition in a transcript of a child's utterances. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [van Santen, Jan P. H.; Hill, Alison Presmanes] Oregon Hlth & Sci Univ, Ctr Spoken Language Understanding, Beaverton, OR 97006 USA. [Sproat, Richard W.] Google New York, New York, NY USA. RP van Santen, JPH (reprint author), Oregon Hlth & Sci Univ, Ctr Spoken Language Understanding, 20000 NW Walker Rd, Beaverton, OR 97006 USA. EM janphvansanten@gmail.com FU National Institute on Deafness and Other Communication Disorders [R01DC012033, R01DC007129-01]; Autism Speaks [2407] FX Grant sponsor: National Institute on Deafness and Other Communication Disorders; Grant numbers: R01DC012033, R01DC007129-01.Grant sponsor: Autism Speaks; Grant number: Innovative Technology for Autism Grant 2407. CR Ahearn WH, 2007, J APPL BEHAV ANAL, V40, P263, DOI 10.1901/jaba.2007.30-06 American Psychiatric Association, 2011, PROP DRAFT REV DSM D American Psychiatric Association, 2000, DIAGN STAT MAN MENT ANSCOMBE FJ, 1948, BIOMETRIKA, V35, P246, DOI 10.2307/2332343 Bishop DVM, 2002, J CHILD PSYCHOL PSYC, V43, P917, DOI 10.1111/1469-7610.00114 Cullen B, 2005, INT J GERIATR PSYCH, V20, P686, DOI 10.1002/gps.1344 Dollaghan C, 1998, J SPEECH LANG HEAR R, V41, P1136 Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd FAY WH, 1968, J SPEECH HEAR RES, V11, P365 Fombonne E., 2011, AUTISM SPECTRUM DISO Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Grossi D., 2012, J INTELLECTUAL DISAB, DOI 10.1111/j.1365-2788.2012.01579.x Hobson RP, 2010, J AUTISM DEV DISORD, V40, P403, DOI 10.1007/s10803-009-0882-5 Jones R. M., 2012, BEHAV BRAIN RES KANNER L, 1946, AM J PSYCHIAT, V103, P242 Klin A, 2000, J AUTISM DEV DISORD, V30, P163, DOI 10.1023/A:1005415823867 Korkman M., 1998, NEPSY DEV NEUROPSYCH Lee LC, 2007, RES AUTISM SPECT DIS, V1, P126, DOI 10.1016/j.rasd.2006.08.004 Leyfer OT, 2008, AUTISM RES, V1, P284, DOI 10.1002/aur.43 Lord C, 1997, J AUTISM DEV DISORD, V27, P501, DOI 10.1023/A:1025873925661 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 MacDonald R, 2007, RES DEV DISABIL, V28, P266, DOI 10.1016/j.ridd.2006.01.004 MCEVOY RE, 1988, J AUTISM DEV DISORD, V18, P657, DOI 10.1007/BF02211883 Murphy MM, 2007, J INTELL DISABIL RES, V51, P387, DOI 10.1111/j.1365-2788.2006.00888.x PACCIA JM, 1982, J SPEECH HEAR RES, V25, P42 PAUL R, 1987, J AUTISM DEV DISORD, V17, P457, DOI 10.1007/BF01486963 PRIZANT BM, 1981, J SPEECH HEAR DISORD, V46, P241 Prizant B. M., 1983, SEMIN SPEECH LANG, V4, P63 PRIZANT BM, 1983, J SPEECH HEAR DISORD, V48, P296 Ritvo E. R., 1977, J PEDIATR PSYCHOL, V2, P146, DOI [10.1093/jpepsy/2.4.146, DOI 10.1093/JPEPSY/2.4.146] Roberts J, 2007, J SPEECH LANG HEAR R, V50, P475, DOI 10.1044/1092-4388(2007/033) ROBERTS JMA, 1989, J AUTISM DEV DISORD, V19, P271, DOI 10.1007/BF02211846 RUTTER M, 1968, J CHILD PSYCHOL PSYC, V9, P1, DOI 10.1111/j.1469-7610.1968.tb02204.x RUTTER M, 1967, BRIT J PSYCHIAT, V113, P1183, DOI 10.1192/bjp.113.504.1183 Rutter M., 2003, SOCIAL COMMUNICATION Sarimski K, 1997, EUR CHILD ADOLES PSY, V6, P26 Schuler A., 1979, J SPEECH HEAR DISORD, V64, P411 Semel E., 2003, CLIN EVALUATION LANG, V4th Semel E., 2004, CLIN EVALUATION LANG Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087) SIMON N, 1975, ARCH GEN PSYCHIAT, V32, P1439 SPITZER RL, 1990, J AM ACAD CHILD PSY, V29, P855, DOI 10.1097/00004583-199011000-00003 SUDHALTER V, 1990, AM J MENT RETARD, V94, P431 Tager-Flusberg H., 2005, AUTISM PERVASIVE DEV, V1, P335 Tager-Flusberg H, 2009, J SPEECH LANG HEAR R, V52, P643, DOI 10.1044/1092-4388(2009/08-0136) Troyb E., 2011, NEUROPSYCHOLOGY AUTI, P9 Van Santen J, 2010, AUTISM, V14, P215, DOI 10.1177/1362361309363281 Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd Wechsler D., 2003, WISC 4 TECHNICAL INT Yule W., 1987, LANGUAGE DEV DISORDE NR 50 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 372 EP 383 DI 10.1002/aur.1301 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600008 PM 23661504 ER PT J AU Pu, DH Shen, YP Wu, J AF Pu, Danhua Shen, Yiping Wu, Jie TI Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis SO AUTISM RESEARCH LA English DT Article DE methylenetetrahydrofolate reductase; polymorphism; autism spectrum disorders; folic acid; meta-analysis ID CHINESE HAN POPULATION; METHYLENETETRAHYDROFOLATE REDUCTASE; OXIDATIVE STRESS; CHILDREN; PREGNANCY; SELECTION; C677T; TWIN AB Methylenetetrahydrofolate reductase (MTHFR) is essential for DNA biosynthesis and the epigenetic process of DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth defects, neurological disorders, and cancers. However, reports on the association of MTHFR polymorphisms with autism spectrum disorders (ASD) are inconclusive. Therefore, we investigated the relationship of the MTHFR polymorphisms (C677T and A1298C) and the risk of ASD by meta-analysis. Up to December 2012, eight case-control studies involving 1672 patients with ASD and 6760 controls were included for meta-analysis. The results showed that the C677T polymorphism was associated with significantly increased ASD risk in all the comparison models [T vs. C allele (frequency of allele): odds ratio (OR)=1.42, 95% confidence interval (CI): 1.09-1.85; CT vs. CC (heterozygote): OR=1.48, 95% CI: 1.09-2.00; TT vs. CC (homozygote): OR=1.86, 95% CI: 1.08-3.20; CT+TT vs. CC (dominant model): OR=1.56, 95% CI: 1.12-2.18; and TT vs. CC+CT (recessive model): OR=1.51, 95% CI: 1.02-2.22], whereas the A1298C polymorphism was found to be significantly associated with reduced ASD risk but only in a recessive model (CC vs. AA+AC: OR=0.73, 95% CI: 0.56-0.97). In addition, we stratified the patient population based on whether they were from a country with food fortification of folic acid or not. The meta-analysis showed that the C677T polymorphism was found to be associated with ASD only in children from countries without food fortification. Our study indicated that the MTHFR C677T polymorphism contributes to increased ASD risk, and periconceptional folic acid may reduce ASD risk in those with MTHFR 677C>T polymorphism. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Pu, Danhua; Wu, Jie] Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China. [Pu, Danhua; Wu, Jie] Nanjing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Nanjing 210029, Jiangsu, Peoples R China. [Shen, Yiping] Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Shanghai 200030, Peoples R China. [Shen, Yiping] Boston Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA. [Shen, Yiping] Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA. [Shen, Yiping] Harvard Univ, Sch Med, Boston, MA 02115 USA. RP Wu, J (reprint author), Nanjing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China. EM Yiping.Shen@childrens.harvard.edu; jie.wuyale@gmail.com FU Priority Academic Program Development of Jiangsu Higher Education Institutions FX Grant sponsor: A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions. CR Algasham A, 2009, GENET TEST MOL BIOMA, V13, P817, DOI 10.1089/gtmb.2009.0019 Ali A, 2011, ACTA BIOCHIM POL, V58, P547 [Anonymous], 2011, COCHRANE HDB SYSTEMA Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention, 2012, MMWR SURVEILLANCE SU, V61, P1 BAILEY A, 1995, PSYCHOL MED, V25, P63 Beard CM, 2011, MED HYPOTHESES, V77, P15, DOI 10.1016/j.mehy.2011.03.013 Boris M., 2004, J AM PHYS SURG, V9, P106 Sandler AD, 2001, PEDIATRICS, V107, P1221 Currenti SA, 2010, CELL MOL NEUROBIOL, V30, P161, DOI 10.1007/s10571-009-9453-8 dos Santos PAC, 2010, PSYCHIAT GENET, V20, P187, DOI 10.1097/YPG.0b013e32833a2220 Egger M, 1997, BRIT MED J, V315, P629 Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896 FROSST P, 1995, NAT GENET, V10, P111, DOI 10.1038/ng0595-111 Frustaci A, 2012, FREE RADICAL BIO MED, V52, P2128, DOI 10.1016/j.freeradbiomed.2012.03.011 Guerini FR, 2011, J NEUROIMMUNOL, V230, P135, DOI 10.1016/j.jneuroim.2010.10.019 Guo TY, 2012, GENET TEST MOL BIOMA, V16, P968, DOI 10.1089/gtmb.2012.0091 Haggarty P, 2008, BJOG-INT J OBSTET GY, V115, P851, DOI 10.1111/j.1471-0528.2008.01737.x Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76 James SJ, 2006, AM J MED GENET B, V141B, P947, DOI 10.1002/ajmg.b.30366 Keller F, 2003, MOL NEUROBIOL, V28, P1, DOI 10.1385/MN:28:1:1 Lauritsen MB, 2001, ACTA PSYCHIAT SCAND, V103, P411, DOI 10.1034/j.1600-0447.2001.00086.x Li XP, 2010, PSYCHIAT GENET, V20, P113, DOI 10.1097/YPG.0b013e32833a216f Liu XD, 2011, J AUTISM DEV DISORD, V41, P938, DOI 10.1007/s10803-010-1120-x McLellan A, 2005, DEV MED CHILD NEUROL, V47, P666, DOI 10.1017/S0012162205001362 Mohammad NS, 2009, PSYCHIAT GENET, V19, P171, DOI 10.1097/YPG.0b013e32832cebd2 Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472 Paca SP, 2009, J CELLULAR MOL MED, V13, P4229, DOI 10.1111/j.1582-4934.2008.00463.x Rogers EJ, 2008, MED HYPOTHESES, V71, P406, DOI 10.1016/j.mehy.2008.04.013 Schmidt RJ, 2012, AM J CLIN NUTR, V96, P80, DOI 10.3945/ajcn.110.004416 Schmidt RJ, 2011, EPIDEMIOLOGY, V22, P476, DOI 10.1097/EDE.0b013e31821d0e30 Weiss LA, 2009, EXPERT REV MOL DIAGN, V9, P795, DOI [10.1586/erm.09.59, 10.1586/ERM.09.59] Zamora Javier, 2006, BMC Med Res Methodol, V6, P31, DOI 10.1186/1471-2288-6-31 NR 32 TC 5 Z9 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 384 EP 392 DI 10.1002/aur.1300 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600009 PM 23653228 ER PT J AU Jarrold, W Mundy, P Gwaltney, M Bailenson, J Hatt, N McIntyre, N Kim, K Solomon, M Novotny, S Swain, L AF Jarrold, William Mundy, Peter Gwaltney, Mary Bailenson, Jeremy Hatt, Naomi McIntyre, Nancy Kim, Kwanguk Solomon, Marjorie Novotny, Stephanie Swain, Lindsay TI Social Attention in a Virtual Public Speaking Task in Higher Functioning Children With Autism SO AUTISM RESEARCH LA English DT Article DE cognition and learning; school-aged development; social attention; individual differences ID PERVASIVE DEVELOPMENTAL DISORDERS; COGNITIVE-BEHAVIORAL THERAPY; JOINT ATTENTION; SPECTRUM DISORDERS; SCREENING QUESTIONNAIRE; EXECUTIVE FUNCTION; DEFICIT/HYPERACTIVITY DISORDER; ASPERGER-SYNDROME; TOTAL POPULATION; ANXIETY AB Impairments in social attention play a major role in autism, but little is known about their role in development after preschool. In this study, a public speaking task was used to study social attention, its moderators, and its association with classroom learning in elementary and secondary students with higher functioning autism spectrum disorder (HFASD). Thirty-seven students with HFASD and 54 age- and intelligence quotient (IQ)-matched peers without symptoms of ASD were assessed in a virtual classroom public speaking paradigm. This paradigm assessed the ability to attend to nine avatar peers seated at a table, while simultaneously answering self-referenced questions. Students with HFASD looked less frequently to avatar peers in the classroom while talking. However, social attention was moderated in the HFASD sample such that students with lower IQ, and/or more symptoms of social anxiety, and/or more attention deficit/hyperactivity disorder inattentive symptoms, displayed more atypical social attention. Group differences were more pronounced when the classroom contained social avatars versus nonsocial targets. Moreover, measures of social attention rather than nonsocial attention were significantly associated with parent report and objective measures of learning in the classroom. The data in this study support the hypothesis of the Social Attention Model of ASD that social attention disturbance remains part of the school-aged phenotype of autism that is related to syndrome-specific problems in social learning. More research of this kind would likely contribute to advances in the understanding of the development of the spectrum of autism and educational intervention approaches for affected school-aged children. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Jarrold, William; Mundy, Peter; Kim, Kwanguk; Solomon, Marjorie] Univ Calif Davis, Dept Psychiat, MIND Inst, Sacramento, CA USA. [Mundy, Peter; Gwaltney, Mary; McIntyre, Nancy; Swain, Lindsay] Univ Calif Davis, Sch Educ, Davis, CA USA. [Mundy, Peter] Univ Calif Davis, Ctr Mind & Brain, Davis, CA USA. [Bailenson, Jeremy] Stanford Univ, Dept Commun Sci, Palo Alto, CA 94304 USA. [Hatt, Naomi] Univ Calif Davis, Dept Psychol, Davis, CA USA. [Novotny, Stephanie] Univ Calif Davis, Sacramento, CA USA. RP Mundy, P (reprint author), UC Davis Sch Educ, 1 Shields Ave, Davis, CA 95616 USA. EM pcmundy@ucdavis.edu FU NIH [1R21MH085904]; IES [R324A120168]; UC Davis Center for Mind and Brain; UC Davis Lisa Capps Endowment for Research on Neurodevelopmental Disorders and Education FX This research would not have been possible without support from NIH grant 1R21MH085904, IES Grant R324A120168, the UC Davis Center for Mind and Brain, and the UC Davis Lisa Capps Endowment for Research on Neurodevelopmental Disorders and Education. We would also like to thank Sally Ozonoff (UC Davis) and Thomas Parsons (USC) for their instrumental consultation on this research. CR Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003 Anderson PL, 2005, DEPRESS ANXIETY, V22, P156, DOI 10.1002/da.20090 Ashburner J, 2010, RES AUTISM SPECT DIS, V4, P18, DOI 10.1016/j.rasd.2009.07.002 Bailenson JN, 2008, J LEARN SCI, V17, P102, DOI [10.1080/10508400701793141, 10.1080/10509400701793141] Bellini S, 2006, FOCUS AUTISM OTHER D, V21, P138, DOI DOI 10.1177/10883576060210030201 Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201 Belmonte MK, 2003, COGNITIVE BRAIN RES, V17, P651, DOI 10.1016/S0926-6410(03)00189-7 Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444 Bhat AN, 2010, J CHILD PSYCHOL PSYC, V51, P989, DOI 10.1111/j.1469-7610.2010.02262.x Blakemore SJ, 2006, J CHILD PSYCHOL PSYC, V47, P296, DOI 10.1111/j.1469-7610.2006.01611.x Bono MA, 2004, J AUTISM DEV DISORD, V34, P495, DOI 10.1007/s10803-004-2545-x Breaux K., 2010, 1 NCS PEARS INC, P1 Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199 Conners K., 2010, CONNERS Constantino J., 2004, SOCIAL RESPONSIVENES Cornwell BR, 2006, BIOL PSYCHIAT, V59, P664, DOI 10.1016/j.biopsych.2005.09.015 Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x Davidson RJ, 2000, BIOL PSYCHIAT, V47, P85, DOI 10.1016/S0006-3223(99)00222-X Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488 Drahota A, 2011, J AUTISM DEV DISORD, V41, P257, DOI 10.1007/s10803-010-1037-4 Ehlers S, 1999, J AUTISM DEV DISORD, V29, P129, DOI 10.1023/A:1023040610384 Elison JT, 2012, RES AUTISM SPECT DIS, V6, P842, DOI 10.1016/j.rasd.2011.11.005 Estes A, 2011, J AUTISM DEV DISORD, V41, P1044, DOI 10.1007/s10803-010-1127-3 Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016 Freeth M, 2010, J AUTISM DEV DISORD, V40, P534, DOI 10.1007/s10803-009-0893-2 Im-Bolter N, 2006, CHILD DEV, V77, P1822, DOI 10.1111/j.1467-8624.2006.00976.x Kadesjo B, 1999, J AUTISM DEV DISORD, V29, P327, DOI 10.1023/A:1022115520317 Kail R, 2000, J SCHOOL PSYCHOL, V38, P51, DOI 10.1016/S0022-4405(99)00036-9 Kandalaft MR, 2013, J AUTISM DEV DISORD, V43, P34, DOI 10.1007/s10803-012-1544-6 Kasari C., 2006, J AUTISM DEV DISORD, V40, P1045 Kasari C, 2008, J CONSULT CLIN PSYCH, V76, P125, DOI 10.1037/0022-006X.76.1.125 Kim K., 2012, FRONTIERS NEUROSCIEN, V6, P1 KLIN A, 1991, J AUTISM DEV DISORD, V21, P29, DOI 10.1007/BF02206995 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 Koolen S, 2012, J AUTISM DEV DISORD, V42, P805, DOI 10.1007/s10803-011-1310-1 Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030 Machalicek W, 2008, RES AUTISM SPECT DIS, V2, P395, DOI 10.1016/j.rasd.2007.07.001 March JS, 1997, J AM ACAD CHILD PSY, V36, P554, DOI 10.1097/00004583-199704000-00019 Matheis RJ, 2007, CLIN NEUROPSYCHOL, V21, P146, DOI 10.1080/13854040601100668 Mayes SD, 2008, J AUTISM DEV DISORD, V38, P428, DOI 10.1007/s10803-007-0410-4 Mitchell P, 2007, J AUTISM DEV DISORD, V37, P589, DOI 10.1007/s10803-006-0189-8 Moore D., 2005, FOCUS AUTISM OTHER D, V20, P231, DOI DOI 10.1177/10883576050200040501 Mundy P, 2010, NEURAL NETWORKS, V23, P985, DOI 10.1016/j.neunet.2010.08.009 Mundy P, 2003, J CHILD PSYCHOL PSYC, V44, P793, DOI 10.1111/1469-7610.00165 Mundy P, 2007, CURR DIR PSYCHOL SCI, V16, P269, DOI 10.1111/j.1467-8721.2007.00518.x MUNDY P, 1995, DEV PSYCHOPATHOL, V7, P63 MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x Mundy P, 2001, INT REV RES MENT RET, V23, P139 Mundy P, 2009, AUTISM RES, V2, P2, DOI 10.1002/aur.61 Mundy P., 2012, AUTISM ED, V1, P3 Mundy P., 2013, OXFORD HDB DEV PSYCH, P217 Newman L., 2007, SECONDARY SCH EXPERI Noland JS, 2010, DEVELOPMENTAL SCI, V13, P244, DOI 10.1111/j.1467-7687.2009.00882.x O'Hearn K, 2010, NEUROPSYCHOLOGIA, V48, P3955, DOI 10.1016/j.neuropsychologia.2010.08.024 Parsons S., 2011, EUROPEAN J SPECIAL N, V26, P47, DOI 10.1080/08856257.2011.543532 Parsons T. D., 2006, CHILD NEUROPSYCHOL, V13, P363 Pelphrey KA, 2008, DEV PSYCHOPATHOL, V20, P1081, DOI 10.1017/S0954579408000515 Picard RW, 2009, PHILOS T R SOC B, V364, P3575, DOI 10.1098/rstb.2009.0143 Posserud MB, 2006, J CHILD PSYCHOL PSYC, V47, P167, DOI 10.1111/j.1469-7610.2005.01462.x Rizzo AA, 2006, CNS SPECTRUMS, V11, P35 Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569 Rutter M., 2003, SOCIAL COMMUNICATION Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Schwartz C, 2010, J AUTISM DEV DISORD, V40, P100, DOI 10.1007/s10803-009-0843-z Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261 Sinzig J, 2008, EUR CHILD ADOLES PSY, V17, P63, DOI 10.1007/s00787-007-0637-9 Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9 Sumpter S., 2010, PSYCHONEUROENDOCRINO, V35, P1510 van West D, 2009, EUR CHILD ADOLES PSY, V18, P543, DOI 10.1007/s00787-009-0011-1 Wechsler D, 1999, WECHSLER ABBREVIATED White SW, 2007, J AUTISM DEV DISORD, V37, P1403, DOI 10.1007/s10803-006-0281-0 Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103 NR 75 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 393 EP 410 DI 10.1002/aur.1302 PG 18 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600010 PM 23696132 ER PT J AU Berger, NI Ingersoll, B AF Berger, Natalie I. Ingersoll, Brooke TI An Exploration of Imitation Recognition in Young Children With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism; imitation; imitation recognition; social cognition ID COMMUNICATION DEFICITS; SOCIAL COGNITION AB The ability to recognize when one is being imitated has been hypothesized to be an important developmental process related to the emergence of more advanced social-cognitive skills. While a series of behaviors indicating progressively more mature imitation recognition (IR) skills has been assessed in typically developing children, empirical work with children with autism spectrum disorders (ASDs) has largely focused on basic social responses to an imitative adult (e.g. increases in eye contact). Limited work has explored more mature IR behaviors in this population. This study compared the degree to which children with ASD engage in different behaviors thought to be indicative of IR during a naturalistic imitation task and the relationship between different types of IR behaviors and social-cognitive skills (i.e. imitation, language, social reciprocity, and joint attention). Thirty children with ASD were administered standardized measures of cognitive level, language, joint attention, social reciprocity, and imitation. IR behaviors were observed during periods of contingent imitation by an adult. Participants engaged more frequently in less mature (e.g. looking at the experimenter's toy or face) than more mature IR behaviors (e.g. testing the experimenter's intent to imitate). After controlling for developmental level, social reciprocity, object imitation, and gesture imitation were positively correlated with more mature IR. These findings suggest that the development of more mature IR skills is related to the development of other social-cognitive skills in children with ASD and provide additional empirical support for reports of more mature IR observed in this population. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Berger, Natalie I.; Ingersoll, Brooke] Michigan State Univ, E Lansing, MI 48824 USA. RP Berger, NI (reprint author), Michigan State Univ, Dept Psychol, 316 Phys Rd,Room 69F, E Lansing, MI 48824 USA. EM bergerna@msu.edu RI Ingersoll, Brooke/A-9117-2012 CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Asendorpf S. B., 1996, DEV PSYCHOL, V32, P313 Baron-Cohen S, 2001, INT REV RES MENT RET, V23, P169 Bayley N, 2006, BAYLEY SCALES INFANT, V3rd Charman T, 1997, DEV PSYCHOL, V33, P781, DOI 10.1037//0012-1649.33.5.781 DAWSON G, 1984, J ABNORM CHILD PSYCH, V12, P209, DOI 10.1007/BF00910664 D'Entremont B, 2007, J AUTISM DEV DISORD, V37, P1665, DOI 10.1007/s10803-006-0291-y Escalona A, 2002, J AUTISM DEV DISORD, V32, P141, DOI 10.1023/A:1014896707002 Field T, 2001, AUTISM, V5, P317, DOI 10.1177/1362361301005003008 Gallese V, 2006, BRAIN RES, V1079, P15, DOI 10.1016/j.brainres.2006.01.054 HARTMANN DP, 1977, J APPL BEHAV ANAL, V10, P103, DOI 10.1901/jaba.1977.10-103 Heimann M, 2006, INFANT CHILD DEV, V15, P297, DOI 10.1002/icd.463 Ingersoll B, 2011, RES AUTISM SPECT DIS, V5, P1078, DOI 10.1016/j.rasd.2010.12.001 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 McDuffie A, 2007, J AUTISM DEV DISORD, V37, P401, DOI 10.1007/s10803-006-0175-1 MCEVOY RE, 1993, J CHILD PSYCHOL PSYC, V34, P563, DOI 10.1111/j.1469-7610.1993.tb01036.x Meltzoff A. N., 1993, UNDERSTANDING OTHER, P335 Meltzoff A. N, 2005, PERSPECTIVES IMITATI, V2, P55 Meltzoff AN, 1990, SELF TRANSITION INFA, P139 Meltzoff AN, 2011, WILEY BLACKWELL HDB, P49 Meltzoff AN, 2003, PHILOS T R SOC B, V358, P491, DOI 10.1098/rstb.2002.1261 Nadel J, 2004, INTERACTION STUDIES, V5, P45, DOI 10.1075/is.5.1.04nad Nadel J., 2002, IMITATIVE MIND DEV E, P46 Nadel J., 2002, ADV CONSCIOUSNESS RE, V45, P119 Nadel J., 2005, INTERACTION STUDIES, V6, P447, DOI 10.1075/is.6.3.09nad Nadel J., 2004, J COGN BEHAV PSYCHOT, V4, P165 Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162 Seibert J. M., 1982, INFANT MENT HEALTH J, V3, P244, DOI DOI 10.1002/1097-0355(198224)3:4<244::AID-IMHJ2280030406>3.0.CO;2-R TIEGERMAN E, 1984, J AUTISM DEV DISORD, V14, P27, DOI 10.1007/BF02408553 Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th NR 30 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 411 EP 416 DI 10.1002/aur.1303 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600011 PM 23696180 ER PT J AU Venker, CE Eernisse, ER Saffran, JR Weismer, SE AF Venker, Courtney E. Eernisse, Elizabeth R. Saffran, Jenny R. Weismer, Susan Ellis TI Individual Differences in the Real-Time Comprehension of Children with ASD SO AUTISM RESEARCH LA English DT Article DE autism; comprehension; language processing; receptive vocabulary; eye-gaze methodology; individual differences ID AUTISM SPECTRUM DISORDERS; SPOKEN WORD RECOGNITION; LATE-TALKING TODDLERS; AGE-OF-ACQUISITION; LANGUAGE-ACQUISITION; YOUNG-CHILDREN; PRESCHOOL-CHILDREN; VOCABULARY GROWTH; JOINT ATTENTION; IMPAIRMENT AB Many children with autism spectrum disorders (ASD) demonstrate deficits in language comprehension, but little is known about how they process spoken language as it unfolds. Real-time lexical comprehension is associated with language and cognition in children without ASD, suggesting that this may also be the case for children with ASD. This study adopted an individual differences approach to characterizing real-time comprehension of familiar words in a group of 34 three- to six-year-olds with ASD. The looking-while-listening paradigm was employed; it measures online accuracy and latency through language-mediated eye movements and has limited task demands. On average, children demonstrated comprehension of the familiar words, but considerable variability emerged. Children with better accuracy were faster to process the familiar words. In combination, processing speed and comprehension on a standardized language assessment explained 63% of the variance in online accuracy. Online accuracy was not correlated with autism severity or maternal education, and nonverbal cognition did not explain unique variance. Notably, online accuracy at age 51/2 was related to vocabulary comprehension 3 years earlier. The words typically learned earliest in life were processed most quickly. Consistent with a dimensional view of language abilities, these findings point to similarities in patterns of language acquisition in typically developing children and those with ASD. Overall, our results emphasize the value of examining individual differences in real-time language comprehension in this population. We propose that the looking-while-listening paradigm is a sensitive and valuable methodological tool that can be applied across many areas of autism research. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Venker, Courtney E.; Eernisse, Elizabeth R.; Saffran, Jenny R.; Weismer, Susan Ellis] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA. RP Venker, CE (reprint author), Univ Wisconsin, Waisman Ctr, 1500 Highland Ave Room 475, Madison, WI 53705 USA. EM cgerickson@wisc.edu FU National Institute on Deafness & Other Communication Disorders [R01DC007223, T32DC005359, F31DC009142]; National Institute of Child Health & Human Development [R37HD037466, P30HD003352] FX First and foremost, we would like to thank the children and families who participated in this study. We appreciate their generosity and their commitment to this research. We would also like to thank Anna Dorrance, Taryn Stricker, and Meghan Davidson for their assistance with eye-gaze coding. Thanks also to Chris Potter, Casey Lew-Williams, Sara Kover, Brianna McMillan, and Erica Wojcik for helpful discussions about the looking-while-listening paradigm. Funding for this study was provided by the National Institute on Deafness & Other Communication Disorders (R01DC007223, T32DC005359, F31DC009142) and the National Institute of Child Health & Human Development (R37HD037466, P30HD003352). CR Brock J, 2008, COGNITION, V108, P896, DOI 10.1016/j.cognition.2008.06.007 Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482 Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199 Dale PS, 1996, BEHAV RES METH INS C, V28, P125, DOI 10.3758/BF03203646 Dollaghan CA, 2004, J SPEECH LANG HEAR R, V47, P464, DOI 10.1044/1092-4388(2004/037) Edelson L., 2008, INT M AUT RES LOND Eernisse E., 2011, S RES CHILD LANG DIS Fenson L, 1993, MACARTHUR COMMUNICAT Fernald A, 2012, CHILD DEV, V83, P203, DOI 10.1111/j.1467-8624.2011.01692.x Fernald A, 2008, DEVELOPMENTAL PSYCHOLINGUISTICS: ON-LINE METHODS IN CHILDREN'S LANGUAGE PROCESSING, P97 Fernald A, 2001, CHILD DEV, V72, P1003, DOI 10.1111/1467-8624.00331 Fernald A, 2006, DEV PSYCHOL, V42, P98, DOI 10.1037/0012-1649.42.1.98 Garlock VM, 2001, J MEM LANG, V45, P468, DOI 10.1006/jmla.2000.2784 Gernsbacher MA, 2005, TRENDS LANG ACQUIS R, V4, P73 Goodwin A, 2012, AUTISM RES, V5, P109, DOI 10.1002/aur.1220 Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Grieco-Calub TM, 2009, J SPEECH LANG HEAR R, V52, P1390, DOI 10.1044/1092-4388(2009/08-0154) Hudry K, 2010, INT J LANG COMM DIS, V45, P681, DOI 10.3109/13682820903461493 Iarocci G, 2006, J AUTISM DEV DISORD, V36, P77, DOI 10.1007/s10803-005-0044-3 Joseph RM, 2002, J CHILD PSYCHOL PSYC, V43, P807, DOI 10.1111/1469-7610.00092 Juhasz BJ, 2005, PSYCHOL BULL, V131, P684, DOI 10.1037/0033-2909.131.5.684 Kelly D. J., 2012, DEVELOPMENTAL SCI, V16, P56 Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287 Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x Leonard L., 1991, LANG SPEECH HEAR SER, V22, P66 Lord C., 2002, AUTISM DIAGNOSTIC OB Luyster R, 2009, J AUTISM DEV DISORD, V39, P1305, DOI 10.1007/s10803-009-0746-z Luyster RJ, 2008, J AUTISM DEV DISORD, V38, P1426, DOI 10.1007/s10803-007-0510-1 Marchman VA, 2008, DEVELOPMENTAL SCI, V11, pF9, DOI 10.1111/j.1467-7687.2008.00671.x Mullen E, 1995, MULLEN SCALES EARLY MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861 Naigles LR, 2011, AUTISM RES, V4, P422, DOI 10.1002/aur.223 Norbury CF, 2010, NEUROPSYCHOLOGIA, V48, P4012, DOI 10.1016/j.neuropsychologia.2010.10.015 Rescorla L, 2009, J SPEECH LANG HEAR R, V52, P16, DOI 10.1044/1092-4388(2008/07-0171) Rescorla L, 2013, J CHILD LANG, V40, P47, DOI 10.1017/S0305000912000232 Romberg AR, 2010, WIRES COGN SCI, V1, P906, DOI 10.1002/wcs.78 Rutter M., 2003, ADI R AUTISM DIAGNOS Shumway S, 2012, AUTISM RES, V5, P267, DOI 10.1002/aur.1238 Swensen LD, 2007, CHILD DEV, V78, P542, DOI 10.1111/j.1467-8624.2007.01022.x Tager-Flusberg H., 2005, AUTISM PERVASIVE DEV, V1, P335 TAGERFLUSBERG H, 1990, J AUTISM DEV DISORD, V20, P1, DOI 10.1007/BF02206853 Tek S, 2008, AUTISM RES, V1, P208, DOI 10.1002/aur.38 Thurm A, 2007, J AUTISM DEV DISORD, V37, P1721, DOI 10.1007/s10803-006-0300-1 Weismer SE, 2011, J AUTISM DEV DISORD, V41, P1065, DOI 10.1007/s10803-010-1134-4 Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1 Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th NR 48 TC 6 Z9 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 417 EP 432 DI 10.1002/aur.1304 PG 16 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600012 PM 23696214 ER PT J AU Cage, E Pellicano, E Shah, P Bird, G AF Cage, Eilidh Pellicano, Elizabeth Shah, Punit Bird, Geoffrey TI Reputation Management: Evidence for Ability But Reduced Propensity in Autism SO AUTISM RESEARCH LA English DT Article DE reputation management; theory of mind; reward; reciprocity; autism ID SPECTRUM DISORDER; SELF-PRESENTATION; ASPERGER-SYNDROME; SOCIAL COGNITION; MIND; CHILDREN; REWARD; COOPERATION; RECIPROCITY; GENEROSITY AB Previous research has reported that autistic adults do not manage their reputation, purportedly due to problems with theory of mind [Izuma, Matsumoto, Camerer, & Adolphs]. The current study aimed to test alternative explanations for this apparent lack of reputation management. Twenty typical and 19 autistic adults donated to charity and to a person, both when alone and when observed. In an additional manipulation, for half of the participants, the observer was also the recipient of their donations, and participants were told that this observer would subsequently have the opportunity to donate to them (motivation condition). This manipulation was designed to encourage an expectation of a reciprocal tit-for-tat strategy in the participant, which may motivate participants to change their behavior to receive more donations. The remaining participants were told that the person watching was just observing the procedure (no motivation condition). Our results replicated Izuma etal.'s finding that autistic adults did not donate more to charity when observed. Yet, in the motivation condition, both typical and autistic adults donated significantly more to the observer when watched, although this effect was significantly attenuated in autistic individuals. Results indicate that, while individuals with autism may have the ability to think about reputation, a reduced expectation of reciprocal behavior from others may reduce the degree to which they engage in reputation management. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Cage, Eilidh; Pellicano, Elizabeth] Univ London, Ctr Res Autism & Educ CRAE, Dept Psychol & Human Dev, Inst Educ, London WC1H 0NU, England. [Cage, Eilidh; Shah, Punit] Univ London Birkbeck Coll, Dept Psychol Sci, London WC1E 7HX, England. [Pellicano, Elizabeth] Univ Western Australia, Sch Psychol, Perth, WA 6009, Australia. [Bird, Geoffrey] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London, England. [Bird, Geoffrey] UCL, Inst Cognit Neurosci, London, England. RP Cage, E (reprint author), Univ London, Ctr Res Autism & Educ CRAE, Dept Psychol & Human Dev, Inst Educ, 55-59 Gordon Sq, London WC1H 0NU, England. EM e.cage@ioe.ac.uk FU Clothworkers' Foundation; Pears Foundation FX We are extremely grateful to all of the adults who took part in our study, and to Erica Salomone and Nanami Harada for assistance with task procedure. Research at the Centre for Research in Autism and Education (CRAE) is supported by The Clothworkers' Foundation and Pears Foundation. This experiment was realized using Cogent 2000, developed by the Cogent 2000 team at the FIL and the ICN, and Cogent Graphics, developed by John Romaya at the LON at the Wellcome Department of Imaging Neuroscience. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Amodio DM, 2006, NAT REV NEUROSCI, V7, P268, DOI 10.1038/nrn1884 Baez S, 2012, FRONT HUM NEUROSCI, V6, DOI 10.3389/fnhum.2012.00302 BARONCOHEN S, 1992, J CHILD PSYCHOL PSYC, V33, P1141, DOI 10.1111/j.1469-7610.1992.tb00934.x BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 Bateson M, 2006, BIOL LETT-UK, V2, P412, DOI 10.1098/rsbl.2006.0509 Begeer S, 2008, J AUTISM DEV DISORD, V38, P1187, DOI 10.1007/s10803-007-0503-0 Benabou R, 2006, AM ECON REV, V96, P1652, DOI 10.1257/aer.96.5.1652 Cascio CJ, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-9 Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007 Cialdini RB, 2004, ANNU REV PSYCHOL, V55, P591, DOI 10.1146/annurev.psych.55.090902.142015 CLEMENTS WA, 1994, COGNITIVE DEV, V9, P377, DOI 10.1016/0885-2014(94)90012-4 Damiano CR, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-13 Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370 Dichter GS, 2012, J AUTISM DEV DISORD, V42, P147, DOI 10.1007/s10803-011-1221-1 Eckel CC, 1996, GAME ECON BEHAV, V16, P181, DOI 10.1006/game.1996.0081 Frith CD, 2006, BRAIN RES, V1079, P36, DOI 10.1016/j.brainres.2005.12.126 Frith CD, 2008, NEURON, V60, P503, DOI 10.1016/j.neuron.2008.10.032 Frith U, 2004, J CHILD PSYCHOL PSYC, V45, P672, DOI 10.1111/j.1469-7610.2004.00262.x Frith U, 2011, CURR BIOL, V21, pR994, DOI 10.1016/j.cub.2011.11.001 Haley KJ, 2005, EVOL HUM BEHAV, V26, P245, DOI 10.1016/j.evolhumbehav.2005.01.002 HAPPE FGE, 1994, J AUTISM DEV DISORD, V24, P129, DOI 10.1007/BF02172093 Izuma K, 2012, NEUROSCI RES, V72, P283, DOI 10.1016/j.neures.2012.01.003 Izuma K, 2011, P NATL ACAD SCI USA, V108, P17302, DOI 10.1073/pnas.1107038108 Kohls G, 2012, SOCIAL COGNITIVE AFF, V8, P565, DOI 10.1093/scan/nss033 Levine TR, 2002, HUM COMMUN RES, V28, P612, DOI 10.1111/j.1468-2958.2002.tb00828.x Lin A, 2012, FRONT NEUROSCI-SWITZ, V6, DOI 10.3389/fnins.2012.00143 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 PERNER J, 1985, J EXP CHILD PSYCHOL, V39, P437, DOI 10.1016/0022-0965(85)90051-7 Perugini M, 2001, EUR J PERSONALITY, V15, pS19, DOI 10.1002/per.419.abs Perugini M, 2003, EUR J PERSONALITY, V17, P251, DOI 10.1002/per.474 Phan KL, 2010, P NATL ACAD SCI USA, V107, P13099, DOI 10.1073/pnas.1008137107 Rege M, 2004, J PUBLIC ECON, V88, P1625, DOI 10.1016/S0047-2727(03)00021-5 Roekel E. V., 2010, J AUTISM DEV DISORD, V40, P63 Scheeren AM, 2010, AUTISM, V14, P457, DOI 10.1177/1362361310366568 Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122 Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170 Sinclair J., 1999, WHY I DISLIKE PERSON Thomae M., 2012, FIELD METHOD, V25, P74, DOI 10.1177/1525822x12466981 Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd Wechsler D, 2011, WECHSLER ABBREVIATED, V2nd YAMAUCHI KT, 1982, J PERS ASSESS, V46, P522, DOI 10.1207/s15327752jpa4605_14 Yoshida W, 2010, J NEUROSCI, V30, P8815, DOI 10.1523/JNEUROSCI.0400-10.2010 ZAJONC RB, 1965, SCIENCE, V149, P269, DOI 10.1126/science.149.3681.269 NR 44 TC 4 Z9 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 433 EP 442 DI 10.1002/aur.1313 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600013 PM 23836550 ER PT J AU Matthews, NL Goldberg, WA Lukowski, AF AF Matthews, Nicole L. Goldberg, Wendy A. Lukowski, Angela F. TI Theory of Mind in Children with Autism Spectrum Disorder: Do Siblings Matter? SO AUTISM RESEARCH LA English DT Article DE autism; theory of mind; siblings; false belief ID FALSE-BELIEF; INDIVIDUAL-DIFFERENCES; EXECUTIVE FUNCTION; METAANALYSIS; LANGUAGE; RISK AB Research indicates a positive relation between the sibling constellation and theory of mind (ToM) development in typically developing (TD) children. Less is known about this association in children with autism spectrum disorder (ASD). The current study examined the association among the presence and number of siblings, birth order, and false belief (FB) understanding in children with ASD and a TD comparison group. Two FB tasks (change of contents and change of location) and the Peabody Picture Vocabulary Test were administered to 57 children with ASD and 28 TD children during a home visit. One parent of each child reported on demographics and the sibling constellation. Separate hierarchical regressions controlled for age, receptive language ability, and scores on the Social Communication Questionnaire. In children with ASD, no association was observed between presence or number of siblings and ToM. However, the presence of older (but not younger) siblings was found to be positively associated with ToM. Children with ASD who had at least one older sibling performed similarly to the TD group, whereas children with ASD who had no older siblings performed significantly worse than the TD group. These findings indicate an advantage for FB performance in children with ASD who have an older sibling. They may bear on decisions to include older siblings or peers in intervention programs and may also contribute to a more complete understanding of the origins of individual differences in ToM ability in children with ASD. Autism Res 2013, ..: ..-... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Matthews, Nicole L.; Goldberg, Wendy A.; Lukowski, Angela F.] Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92697 USA. RP Goldberg, WA (reprint author), Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92697 USA. EM wendy.goldberg@uci.edu FU Autism Society of America, San Diego Bernard Rimland Memorial Research Grant; School of Social Ecology at the University of California, Irvine Summer Research Grant; University of California, Irvine Undergraduate Research Opportunities Program FX We thank the Autism Society of America, San Diego Bernard Rimland Memorial Research Grant, the School of Social Ecology at the University of California, Irvine Summer Research Grant, and the University of California, Irvine Undergraduate Research Opportunities Program for partial financial support of this project. We gratefully acknowledge the contributions made by members of the undergraduate research team to data collection and coding. We also thank the children and parents who participated in this study. CR Aksoy AB, 2008, KURAM UYGULAMA EGI, V8, P769 Allen CW, 2007, J AUTISM DEV DISORD, V37, P1272, DOI 10.1007/s10803-006-0279-7 American Psychiatric Association, 2013, DIAGN STAT MAN MENT BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 Brown JR, 1996, CHILD DEV, V67, P836, DOI 10.1111/j.1467-8624.1996.tb01767.x Cohen J., 2003, APPL MULTIPLE REGRES Constantino JN, 2010, AM J PSYCHIAT, V167, P1349, DOI 10.1176/appi.ajp.2010.09101470 Cutting AL, 1999, CHILD DEV, V70, P853, DOI 10.1111/1467-8624.00061 Daniels AM, 2012, J AUTISM DEV DISORD, V42, P257, DOI 10.1007/s10803-011-1236-7 DeRosier ME, 2011, J AUTISM DEV DISORD, V41, P1033, DOI 10.1007/s10803-010-1128-2 DUNN J, 1991, CHILD DEV, V62, P1352, DOI 10.1111/j.1467-8624.1991.tb01610.x Dunn L. M., 1997, PPVT 3 PEABODY PICTU Eaves L.C., 2006, J DEV BEHAV PEDIATR, V27, P95, DOI DOI 10.1097/00004703-200604002-00007 Foote RC, 2003, BRIT J DEV PSYCHOL, V21, P45, DOI 10.1348/026151003321164618 Harris P. L., 2005, WHY LANGUAGE MATTERS, P70 Hughes C, 2004, SOC DEV, V13, P590, DOI 10.1111/j.1467-9507.2004.00285.x Hughes C, 2005, DEV NEUROPSYCHOL, V28, P645, DOI 10.1207/s15326942dn2802_5 Jenkins JM, 1996, DEV PSYCHOL, V32, P70, DOI 10.1037/0012-1649.32.1.70 Kaminsky L, 2001, J AUTISM DEV DISORD, V31, P399, DOI 10.1023/A:1010664603039 Kendler KS, 2010, AM J PSYCHIAT, V167, P1291, DOI 10.1176/appi.ajp.2010.10081160 Knott F, 2007, J AUTISM DEV DISORD, V37, P1987, DOI 10.1007/s10803-006-0347-z Lee H, 2010, AM J MED GENET B, V153B, P1119, DOI 10.1002/ajmg.b.31103 Lewis C, 1996, CHILD DEV, V67, P2930, DOI 10.1111/j.1467-8624.1996.tb01896.x Matthews N. L., 2011, DEVELOPMENTAL SCI, V15, P25 McAlister A, 2006, BRIT J DEV PSYCHOL, V24, P733, DOI 10.1348/026151005X70094 McAlister A. R., 2012, CHILD DEV EARLY VIEW McAlister A, 2007, COGNITIVE DEV, V22, P258, DOI 10.1016/j.cogdev.2006.10.009 Milligan K, 2007, CHILD DEV, V78, P622, DOI 10.1111/j.1467-8624.2007.01018.x O'Brien K, 2011, J CHILD PSYCHOL PSYC, V52, P713, DOI 10.1111/j.1469-7610.2011.02389.x Pellicano E, 2010, DEV PSYCHOL, V46, P530, DOI 10.1037/a0018287 PERNER J, 1994, CHILD DEV, V65, P1228, DOI 10.1111/j.1467-8624.1994.tb00814.x Petalas MA, 2012, RES AUTISM SPECT DIS, V6, P546, DOI 10.1016/j.rasd.2011.07.015 Peterson CC, 2012, CHILD DEV, V83, P469, DOI 10.1111/j.1467-8624.2011.01728.x Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879 Rivers JW, 2008, J AUTISM DEV DISORD, V38, P1740, DOI 10.1007/s10803-008-0560-z Ruffman T, 1998, DEV PSYCHOL, V34, P161, DOI 10.1037/0012-1649.34.1.161 Rutter M., 2003, SOCIAL COMMUNICATION Slaughter V, 2007, CHILD DEV, V78, P839, DOI 10.1111/j.1467-8624.2007.01036.x Wellman HM, 2011, CHILD DEV, V82, P780, DOI 10.1111/j.1467-8624.2011.01583.x Wellman HM, 2001, CHILD DEV, V72, P655, DOI 10.1111/1467-8624.00304 WIMMER H, 1991, BRIT J DEV PSYCHOL, V9, P125 Yirmiya N, 1998, PSYCHOL BULL, V124, P283, DOI 10.1037/0033-2909.124.3.283 NR 42 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD OCT PY 2013 VL 6 IS 5 BP 443 EP 453 DI 10.1002/aur.1308 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 238GX UT WOS:000325933600014 PM 23843293 ER PT J AU Johnston, K Dittner, A Bramham, J Murphy, C Knight, A Russell, A AF Johnston, Kate Dittner, Antonia Bramham, Jessica Murphy, Clodagh Knight, Anya Russell, Ailsa TI Attention Deficit Hyperactivity Disorder Symptoms in Adults with Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; attention deficit hyperactivity disorder (ADHD); attention; adults; neuropsychology ID PERVASIVE DEVELOPMENTAL DISORDER; CONTINUOUS PERFORMANCE-TEST; HIGH-FUNCTIONING AUTISM; MULTIPLE CASE SERIES; DEFICIT/HYPERACTIVITY DISORDER; ASPERGER-SYNDROME; DIFFERENTIAL-DIAGNOSIS; SUSTAINED ATTENTION; QUOTIENT AQ; CHILDREN AB Features of attention deficit hyperactivity disorder (ADHD) and impairments on neuropsychological, tests of attention have been documented in children with autism spectrum disorders (ASDs). To date, there has been a lack of research comparing attention in adults with ASD and adults with ADHD. In study 1, 31 adults with ASD and average intellectual function completed self-report measures of ADHD symptoms. These were compared with self-report measures of ADHD symptoms in 38 adults with ADHD and 29 general population controls. In study 2, 28 adults with a diagnosis of ASD were compared with an age- and intelligence quotient-matched sample of 28 adults with ADHD across a range of measures of attention. Study 1 showed that 36.7% of adults with ASD met Diagnostic and Statistical Manual-IV criteria for current ADHD "caseness" (Barkley Current self-report scores questionnaire). Those with a diagnosis of pervasive developmental disordernot otherwise specified were most likely to describe ADHD symptoms. The ASD group differed significantly from both the ADHD and control groups on total and individual symptom self-report scores. On neuropsychological testing, adults with ASD and ADHD showed comparable performance on tests of selective attention. Significant group differences were seen on measures of attentional switching; adults with ADHD were significantly faster and more inaccurate, and individuals with Asperger's syndrome showed a significantly slower and more accurate response style. Self-reported rates of ADHD among adults with ASD are significantly higher than in the general adult population and may be underdiagnosed. Adults with ASD have attentional difficulties on some neuropsychological measures. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Johnston, Kate] Kings Coll London, South London & Maudsley NHS Fdn Trust, Inst Psychiat,Michael Rutter Ctr, Forens Psychol Serv,Natl & Specialist Child & Ado, London SE5 8AZ, England. [Dittner, Antonia; Murphy, Clodagh; Knight, Anya] South London & Maudsley NHS Fdn Trust, London, England. [Bramham, Jessica] Univ Coll Dublin, Dublin 2, Ireland. Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England. RP Johnston, K (reprint author), Kings Coll London, South London & Maudsley NHS Fdn Trust, Inst Psychiat,Michael Rutter Ctr, Forens Psychol Serv,Natl & Specialist Child & Ado, Crespigny Pk, London SE5 8AZ, England. EM kate.johnston@slam.nhs.uk RI Russell, Ailsa/J-8268-2013 OI Russell, Ailsa/0000-0002-8443-9381 CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Anckarsater H, 2006, AM J PSYCHIAT, V163, P1239, DOI 10.1176/appi.ajp.163.7.1239 Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022 Axelrod BN, 2001, ARCH CLIN NEUROPSYCH, V16, P1 Barkley R., 2002, CLIN GUIDE ADULT ADH, P43, DOI 10.1016/B978-012287049-1/50005-0 Barkley R. A., 1998, ATTENTION DEFICIT HY, V2nd BARKLEY RA, 1990, J DEV BEHAV PEDIATR, V11, P343 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 BIEDERMAN J, 1993, AM J PSYCHIAT, V150, P1792 BURACK JA, 1994, J ABNORM PSYCHOL, V103, P535, DOI 10.1037/0021-843X.103.3.535 Calhoun SL, 2005, PSYCHOL SCHOOLS, V42, P333, DOI 10.1002/pits.20067 Casey BJ, 2001, CLIN NEUROSCI RES, V1, P267, DOI 10.1016/S1566-2772(01)00013-5 Chan RCK, 2000, BRAIN INJURY, V14, P227, DOI 10.1080/026990500120709 Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y Corbett BA, 2006, CHILD NEUROPSYCHOL, V12, P335, DOI 10.1080/09297040500350938 de Vries M, 2012, J AUTISM DEV DISORD, V42, P2558, DOI 10.1007/s10803-012-1512-1 Epstein J. N., 2004, CONNORS ADULT ADHD D Franzen M. D., 1987, ARCH CLIN NEUROPSYCH, V2, P265 Gallagher R, 2001, ANN NY ACAD SCI, V931, P148 Gargaro BA, 2011, NEUROSCI BIOBEHAV R, V35, P1081, DOI 10.1016/j.neubiorev.2010.11.002 GARRETSON HB, 1990, J AUTISM DEV DISORD, V20, P101, DOI 10.1007/BF02206860 Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279 Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4 Golden C.J., 1978, STROOP COLOR WORD TE Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68 Greenhill Laurence L., 2002, Journal of the American Academy of Child and Adolescent Psychiatry, V41, p26S Guerts H. M., 2004, J CHILD PSYCHOL PSYC, V45, P836 Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004 Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003 Hill EL, 2006, NEUROPSYCHOLOGIA, V44, P2822, DOI 10.1016/j.neuropsychologia.2006.06.007 Hofvander B, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-35 Holtmann M, 2005, J AM ACAD CHILD PSY, V44, P1101, DOI 10.1097/01.chi.0000177322.57931.2a Homack S, 2004, ARCH CLIN NEUROPSYCH, V19, P725, DOI 10.1016/j.acn.2003.09.003 Jensen VK, 1997, CLIN PEDIATR, V36, P555, DOI 10.1177/000992289703601001 Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P2234, DOI 10.1016/j.neuropsychologia.2007.02.019 Johnston K, 2011, J AUTISM DEV DISORD, V41, P903, DOI 10.1007/s10803-010-1113-9 Ladner JM, 2011, MEAS EVAL COUNS DEV, V44, P215, DOI 10.1177/0748175611417879 Lang R, 2010, DEV NEUROREHABIL, V13, P53, DOI 10.3109/17518420903236288 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Luteijn EF, 2000, EUR CHILD ADOLES PSY, V9, P168 Magnússon Páll, 2006, J Atten Disord, V9, P494, DOI 10.1177/1087054705283650 MatierSharma K, 1995, CHILD NEUROPSYCHOL, V1, P118, DOI 10.1080/09297049508402243 Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303 Nyden A, 2010, RES DEV DISABIL, V31, P1659, DOI 10.1016/j.ridd.2010.04.010 Ornitz E., 1988, BRAIN DYSFUNCT, V1, P309 Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110 Pascualvaca DM, 1998, J AUTISM DEV DISORD, V28, P467, DOI 10.1023/A:1026091809650 Quinn CA, 2003, ARCH CLIN NEUROPSYCH, V18, P379, DOI 10.1016/S0887-6177(02)00150-6 Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026 Robertson IH, 1994, TEST EVERYDAY ATTENT Safren SA, 2005, BEHAV RES THER, V43, P831, DOI 10.1016/j.brat.2004.07.001 Santosh PJ, 2006, CHILD CARE HLTH DEV, V32, P575, DOI 10.1111/j.1365-2214.2006.00631.x Schoechlin C, 2005, ARCH CLIN NEUROPSYCH, V20, P727, DOI 10.1016/j.acn.2005.04.005 SIEGEL BV, 1995, SCHIZOPHR RES, V17, P85, DOI 10.1016/0920-9964(95)00033-I Simon V., 2009, BRIT J PSYCHIAT, V94, P204 Sinzig J., 2008, CHILD ADOL PSYCH CL, V2, P1, DOI [DOI 10.1186/1753-2000-2-4, 10.1186/1753-2000-2-4] Spencer T, 1998, J CLIN PSYCHIAT, V59, P59 SPENCER T, 1994, HARVARD REV PSYCHIAT, V1, P326, DOI 10.3109/10673229409017099 Steele SD, 2007, J AUTISM DEV DISORD, V37, P605, DOI 10.1007/s10803-006-0202-2 Sturm H, 2004, DEV MED CHILD NEUROL, V46, P444, DOI 10.1017/S0012162204000738 Towgood KJ, 2009, NEUROPSYCHOLOGIA, V47, P2981, DOI 10.1016/j.neuropsychologia.2009.06.028 Uttl B, 2001, CLIN NEUROPSYCHOL, V15, P521, DOI 10.1076/clin.15.4.521.1881 Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd Wilens Timothy E, 2004, JAMA, V292, P619, DOI 10.1001/jama.292.5.619 World Health Organization, 1994, INT CLASS DIS Yoshida Y, 2004, EUR CHILD ADOLES PSY, V13, P307, DOI 10.1007/s00787-004-0391-1 NR 67 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2013 VL 6 IS 4 BP 225 EP 236 DI 10.1002/aur.1283 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 200ZY UT WOS:000323111700001 PM 23788522 ER PT J AU Hollocks, MJ Ozsivadjian, A Matthews, CE Howlin, P Simonoff, E AF Hollocks, Matthew J. Ozsivadjian, Ann Matthews, Claire E. Howlin, Patricia Simonoff, Emily TI The Relationship Between Attentional Bias and Anxiety in Children and Adolescents With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; anxiety; attentional bias; cognitive; emotion ID POSTTRAUMATIC-STRESS-DISORDER; PREFRONTAL CORTEX ACTIVATION; RANDOMIZED CONTROLLED-TRIAL; GENERALIZED ANXIETY; PEDIATRIC ANXIETY; ANGRY FACES; DEPRESSION; CHILDHOOD; THREAT; RECOGNITION AB Young people with an autism spectrum disorder (ASD) are more likely to have heightened levels of anxiety compared with their typically developing (non-ASD) peers. The reasons for this are poorly understood, and there has been little research investigating the cognitive correlates of anxiety in individuals with ASD. Typically developing youth with anxiety disorders have frequently been found to show an attentional bias toward threatening information. In this study, we examined whether such a bias was also found in young people with ASD and anxiety symptoms. The protocol utilized two versions of the dot-probe paradigm, the first with emotional faces and the second with emotional words. Participants comprised 38 boys with an ASD and 41 typically developing controls aged 10-16 years of age. Those with an ASD displayed higher levels of parent- and child-rated anxiety (both P<0.001) and depression (P<0.001) compared with controls. However, there were no significant group differences in attentional bias scores and no significant relationship between anxiety and attentional bias in either the face or word tasks, for either group. Our findings suggest that, for young people with ASD, unlike non-ASD individuals with an anxiety disorder, high levels of anxiety may not be associated with attentional bias to threat. This may indicate that anxiety in ASD has different cognitive correlates from anxiety in the typically developing population. Further conclusions, study limitations, and future directions are discussed. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Hollocks, Matthew J.; Simonoff, Emily] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London, England. [Ozsivadjian, Ann] Guys Hosp, Newcomen Ctr, London SE1 9RT, England. [Matthews, Claire E.] Kings Coll London, Sch Med, London, England. [Howlin, Patricia] Kings Coll London, Inst Psychiat, Dept Psychol, London, England. [Simonoff, Emily] Kings Coll London, Biomed Res Ctr Mental Hlth, London, England. RP Hollocks, MJ (reprint author), Inst Psychiat, Dept Child & Adolescent Psychiat, PO85,DeCrespigny Pk, London SE5 8AF, England. EM matthew.hollocks@kcl.ac.uk RI Howlin, Patricia/A-7622-2011 FU Charles Hawkins Fund FX The authors of this manuscript would like to thank all the families and schools who kindly participated in this research. In addition, we would like to thanks the Charles Hawkins Fund for providing some additional funding toward travel and expenses for this study. We would like to thank Charlotte Hibberd for the data collection and Adrienne Knight for her assistance with questionnaire data collection. CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289 Annaz D, 2009, J EXP CHILD PSYCHOL, V102, P456, DOI 10.1016/j.jecp.2008.11.005 Beck AT, 1997, BEHAV RES THER, V35, P49, DOI 10.1016/S0005-7967(96)00069-1 Becker ES, 2001, J ANXIETY DISORD, V15, P147, DOI 10.1016/S0887-6185(01)00055-X Bishop SJ, 2007, TRENDS COGN SCI, V11, P307, DOI 10.1016/j.tics.2007.05.008 Blakeley-Smith A, 2012, RES AUTISM SPECT DIS, V6, P707, DOI 10.1016/j.rasd.2011.07.020 Bogels SM, 2003, BEHAV CHANGE, V20, P160, DOI 10.1375/bech.20.3.160.24836 Costello EJ, 2003, ARCH GEN PSYCHIAT, V60, P837, DOI 10.1001/archpsyc.60.8.837 Cowart MJW, 2011, J ANXIETY DISORD, V25, P972, DOI 10.1016/j.janxdis.2011.06.005 Dalgleish T, 2003, J CLIN CHILD ADOLESC, V32, P10, DOI 10.1207/15374420360533022 Dalgleish T, 2001, PSYCHOL MED, V31, P541 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Derryberry D, 2002, J ABNORM PSYCHOL, V111, P225, DOI 10.1037//0021-843X.111.2.225 Easter J, 2005, J CHILD ADOL PSYCHOP, V15, P563, DOI 10.1089/cap.2005.15.563 Eldar S, 2012, AM J PSYCHIAT, V169, P213, DOI 10.1176/appi.ajp.2011.11060886 Evans DW, 2005, CHILD PSYCHIAT HUM D, V36, P3, DOI 10.1007/s10578-004-3619-x Farrugia S., 2006, FOCUS AUTISM OTHER D, V21, P25, DOI DOI 10.1177/10883576060210010401 Ghaziuddin M, 2002, J AUTISM DEV DISORD, V32, P299, DOI 10.1023/A:1016330802348 Greenaway R, 2010, J AUTISM DEV DISORD, V40, P1179, DOI 10.1007/s10803-010-0977-z Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5 Korkman M., 2007, NEPSY 2 DEV NEUROPSY Kovacs M., 1992, CHILDRENS DEPRESSION Ladouceur CD, 2006, J CHILD PSYCHOL PSYC, V47, P1107, DOI 10.1111/j.1469-7610.2006.01640.x Lang R, 2010, DEV NEUROREHABIL, V13, P53, DOI 10.3109/17518420903236288 Lau Jennifer Y F, 2012, Biol Mood Anxiety Disord, V2, P12, DOI 10.1186/2045-5380-2-12 MACDONALD H, 1989, J CHILD PSYCHOL PSYC, V30, P865, DOI 10.1111/j.1469-7610.1989.tb00288.x MACLEOD C, 1986, J ABNORM PSYCHOL, V95, P15, DOI 10.1037//0021-843X.95.1.15 Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006 McClure EB, 2003, AM J PSYCHIAT, V160, P1172, DOI 10.1176/appi.ajp.160.6.1172 Mogg K, 1998, BEHAV RES THER, V36, P809, DOI 10.1016/S0005-7967(98)00063-1 Mogg K, 2007, BIOL PSYCHOL, V76, P163, DOI 10.1016/j.biopsycho.2007.07.005 Mogg K, 2004, J ABNORM PSYCHOL, V113, P160, DOI 10.1037/0021-843X.113.1.160 Monk CS, 2006, AM J PSYCHIAT, V163, P1091, DOI 10.1176/appi.ajp.163.6.1091 Monk CS, 2008, ARCH GEN PSYCHIAT, V65, P568, DOI 10.1001/archpsyc.65.5.568 Moree BN, 2010, RES AUTISM SPECT DIS, V4, P346, DOI 10.1016/j.rasd.2009.10.015 Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6 Ozsivadjian A, 2012, AUTISM, V16, P107, DOI 10.1177/1362361311431703 Pine DS, 2005, AM J PSYCHIAT, V162, P291, DOI 10.1176/appi.ajp.162.2.291 Rapee RM, 2009, ANNU REV CLIN PSYCHO, V5, P311, DOI 10.1146/annurev.clinpsy.032408.153628 Rodgers J, 2012, J AUTISM DEV DISORD, V42, P175, DOI 10.1007/s10803-011-1225-x Roy AK, 2008, J AM ACAD CHILD PSY, V47, P1189, DOI 10.1097/CHI.0b013e3181825ace Rubin D., 1987, MULTIPLE IMPUTATION Rutter M., 2003, SOCIAL COMMUNICATION Schmukle SC, 2005, EUR J PERSONALITY, V19, P595, DOI 10.1002/per.554 Sofronoff K, 2005, J CHILD PSYCHOL PSYC, V46, P1152, DOI 10.1111/j.1469-7610.2005.00411.x Spence SH, 1998, BEHAV RES THER, V36, P545, DOI 10.1016/S0005-7967(98)00034-5 Stirling LJ, 2006, J CLIN CHILD ADOLESC, V35, P440, DOI 10.1207/s15374424jccp3503_9 Taghavi MR, 1999, J ABNORM CHILD PSYCH, V27, P215, DOI 10.1023/A:1021952407074 Tottenham N, 2009, PSYCHIAT RES, V168, P242, DOI 10.1016/j.psychres.2008.05.006 van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0 VASEY MW, 1995, J ABNORM CHILD PSYCH, V23, P267, DOI 10.1007/BF01447092 Waters AM, 2008, J AM ACAD CHILD PSY, V47, P435, DOI 10.1097/CHI.0b013e3181642992 Waters AM, 2008, BEHAV RES THER, V46, P39, DOI 10.1016/j.brat.2007.10.002 Waters AM, 2010, J BEHAV THER EXP PSY, V41, P158, DOI 10.1016/j.jbtep.2009.12.001 Wechsler D., 2005, WECHSLER INDIVIDUAL Wechsler D, 1999, WECHSLER ABBREVIATED Weisbrot DM, 2005, J CHILD ADOL PSYCHOP, V15, P477, DOI 10.1089/cap.2005.15.477 White SW, 2009, J AUTISM DEV DISORD, V39, P1652, DOI 10.1007/s10803-009-0801-9 White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003 Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x Wood JJ, 2010, CLIN PSYCHOL-SCI PR, V17, P281, DOI 10.1111/j.1468-2850.2010.01220.x Yantis S., 1993, CURRENT DIRECTIONS P, V2, P156, DOI 10.1111/1467-8721.ep10768973 NR 62 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2013 VL 6 IS 4 BP 237 EP 247 DI 10.1002/aur.1285 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 200ZY UT WOS:000323111700002 PM 23907924 ER PT J AU Rajamani, KT Doherty-Lyons, S Bolden, C Willis, D Hoffman, C Zelikoff, J Chen, LC Gu, H AF Rajamani, Keerthi Thirtamara Doherty-Lyons, Shannon Bolden, Crystal Willis, Daniel Hoffman, Carol Zelikoff, Judith Chen, Lung-Chi Gu, Howard TI Prenatal and Early-Life Exposure to High-Level Diesel Exhaust Particles Leads to Increased Locomotor Activity and Repetitive Behaviors in Mice SO AUTISM RESEARCH LA English DT Article DE diesel exhaust particles; early-life exposure; autism; repetitive behaviors ID AUTISM SPECTRUM DISORDERS; FRAGILE-X-SYNDROME; IN-UTERO EXPOSURE; MUTANT MICE; MOUSE MODEL; PSYCHIATRIC-DISORDERS; AIR-POLLUTION; ANXIETY; CHILDREN; MEMORY AB Abundant evidence indicates that both genetic and environmental factors contribute to the etiology of autism spectrum disorders (ASDs). However, limited knowledge is available concerning these contributing factors. An epidemiology study reported a link between increased incidence of autism and living closely to major highways, suggesting a possible role for pollutants from highway traffic. We investigated whether maternal exposure to diesel exhaust particles (DEP) negatively affects fetal development leading to autism-like phenotype in mice. Female mice and their offspring were exposed to DEP during pregnancy and nursing. Adult male offspring were then tested for behaviors reflecting the typical symptoms of ASD patients. Compared to control mice, DEP-exposed offspring exhibited higher locomotor activity, elevated levels of self-grooming in the presence of an unfamiliar mouse, and increased rearing behaviors, which may be relevant to the restricted and repetitive behaviors seen in ASD patients. However, the DEP-exposed mice did not exhibit deficits in social interactions or social communication which are the key features of ASD. These results suggest that early life exposure to DEP could have an impact on mouse development leading to observable changes in animal behaviors. Further studies are needed to reveal other environmental insults and genetic factors that would lead to animal models expressing key phenotypes of the autism spectrum disorders. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Rajamani, Keerthi Thirtamara; Bolden, Crystal; Gu, Howard] Ohio State Univ, Dept Pharmacol, Columbus, OH 43210 USA. [Rajamani, Keerthi Thirtamara] Ohio State Univ, Neurosci Grad Studies Program, Columbus, OH 43210 USA. [Doherty-Lyons, Shannon; Willis, Daniel; Hoffman, Carol; Zelikoff, Judith; Chen, Lung-Chi] NYU, Langone Med Ctr, Dept Environm Med, Tuxedo Pk, NY USA. RP Gu, H (reprint author), Ohio State Univ, 333 West 10th Ave,5184B Graves Hall, Columbus, OH 43210 USA. EM gu.37@osu.edu FU National Institute on drug abuse [DA014610]; NYU NIEHS Center [ES000260] FX Grant sponsor: National Institute on drug abuse; Grant number: DA014610 and in part by the NYU NIEHS Center Grant No. ES000260. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT BAILEY A, 1995, PSYCHOL MED, V25, P63 Benatti C, 2011, BEHAV BRAIN RES, V224, P23, DOI 10.1016/j.bbr.2011.05.011 Blundell J, 2010, J NEUROSCI, V30, P2115, DOI 10.1523/JNEUROSCI.4517-09.2010 Brereton AV, 2006, J AUTISM DEV DISORD, V36, P863, DOI 10.1007/s10803-006-0125-y Brielmaier J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040914 Chao HT, 2010, NATURE, V468, P263, DOI 10.1038/nature09582 CHESS S, 1978, J PEDIATR-US, V93, P699, DOI 10.1016/S0022-3476(78)80921-4 Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x Esbensen AJ, 2003, J AUTISM DEV DISORD, V33, P617, DOI 10.1023/B:JADD.0000005999.27178.55 Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106 Fonken LK, 2011, MOL PSYCHIATR, V16, P987, DOI 10.1038/mp.2011.76 Gillott A, 2001, AUTISM, V5, P277, DOI 10.1177/1362361301005003005 Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68 Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76 Han S, 2012, NATURE, V489, P385, DOI 10.1038/nature11356 Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040 Holmes A, 2003, NEUROPSYCHOPHARMACOL, V28, P1031, DOI 10.1038/sj.npp.1300164 Hougaard KS, 2008, PART FIBRE TOXICOL, V5, DOI 10.1186/1743-8977-5-3 Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6 Jones KL, 2010, INT J DEV NEUROSCI, V28, P529, DOI 10.1016/j.ijdevneu.2010.05.002 King-Herbert AP, 2010, TOXICOL PATHOL, V38, P180, DOI 10.1177/0192623309356450 Kogan JH, 1997, CURR BIOL, V7, P1, DOI 10.1016/S0960-9822(06)00022-4 Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018 Levesque S, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-105 Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0 Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223 Lin L., 2010, ALLERGY ASTHMA CLIN, V6, P7 McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x McNaughton CH, 2008, BEHAV NEUROSCI, V122, P293, DOI [10.1037/0735-7044.122.2.293, 10.1037/0735-7044A22.2.293] Mines MA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009706 Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007 Niedzwiecki M, 2012, ALLERGY, V67, P904, DOI 10.1111/j.1398-9995.2012.02841.x Pearson BL, 2011, GENES BRAIN BEHAV, V10, P228, DOI 10.1111/j.1601-183X.2010.00659.x Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965 Penagarikano O, 2011, CELL, V147, P235, DOI 10.1016/j.cell.2011.08.040 Perera F, 2011, REPROD TOXICOL, V31, P363, DOI 10.1016/j.reprotox.2010.12.055 Rampon C, 2000, NAT NEUROSCI, V3, P238 Reliene R, 2005, MUTAT RES-FUND MOL M, V570, P245, DOI 10.1016/j.mrfmmm.2004.11.010 Rodgers J, 2012, J AUTISM DEV DISORD, V42, P175, DOI 10.1007/s10803-011-1225-x Rodgers J, 2012, J AUTISM DEV DISORD, V42, P2404, DOI 10.1007/s10803-012-1531-y Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d Silverman DT, 2012, J NATL CANCER I, V104, P855, DOI 10.1093/jnci/djs034 Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261 Suzuki T, 2010, PART FIBRE TOXICOL, V7, DOI 10.1186/1743-8977-7-7 Sydbom A, 2001, EUR RESPIR J, V17, P733, DOI 10.1183/09031936.01.17407330 Taniai H, 2008, AM J MED GENET B, V147B, P844, DOI 10.1002/ajmg.b.30740 VANERP AMM, 1994, BEHAV BRAIN RES, V65, P47, DOI 10.1016/0166-4328(94)90072-8 Volk HE, 2011, ENVIRON HEALTH PERSP, V119, P873, DOI 10.1289/ehp.1002835 Watanabe N., 2002, BMC PREGNANCY CHILDB, V2, P2, DOI 10.1186/1471-2393-2-2 Williams G, 2001, DEV MED CHILD NEUROL, V43, P202, DOI 10.1017/S001216220100038X Wrenn CC, 2003, BEHAV NEUROSCI, V117, P21, DOI 10.1037/0735-7044.117.1.21 Yokota S, 2009, NEUROSCI LETT, V449, P38, DOI 10.1016/j.neulet.2008.09.085 Yoshida Seiichi, 2006, Environmental Sciences, V13, P139 NR 56 TC 4 Z9 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2013 VL 6 IS 4 BP 248 EP 257 DI 10.1002/aur.1287 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 200ZY UT WOS:000323111700003 ER PT J AU Pellicano, E AF Pellicano, Elizabeth TI Testing the Predictive Power of Cognitive Atypicalities in Autistic Children: Evidence from a 3-Year Follow-Up Study SO AUTISM RESEARCH LA English DT Article DE predictive; outcome; theory of mind; executive function; central coherence ID EXECUTIVE FUNCTION; CENTRAL COHERENCE; DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; ABLE CHILDREN; FALSE BELIEF; PRETEND PLAY; MIND; BEHAVIOR; TIME AB This follow-up study investigated the predictive power of early cognitive atypicalities. Specifically, it examined whether early individual differences in specific cognitive skills, including theory of mind, executive function, and central coherence, could uniquely account for variation in autistic children's behaviorssocial communication, repetitive behaviors, and interests and insistence on samenessat follow-up. Thirty-seven cognitively able children with an autism spectrum condition were assessed on tests tapping verbal and nonverbal ability, theory of mind (false-belief prediction), executive function (planning ability, cognitive flexibility, and inhibitory control), and central coherence (local processing) at intake and their behavioral functioning (social communication, repetitive behaviors and interests, insistence on sameness) 3 years later. Individual differences in early executive but not theory of mind skills predicted variation in children's social communication. Individual differences in children's early executive function also predicted the degree of repetitive behaviors and interests at follow-up. There were no predictive relationships between early central coherence and children's insistence on sameness. These findings challenge the notion that distinct cognitive atypicalities map on to specific behavioral features of autism. Instead, early variation in executive function plays a key role in helping to shape autistic children's emerging behaviors, including their social communication and repetitive behaviors and interests. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Pellicano, Elizabeth] Univ London, Inst Educ, Dept Psychol & Human Dev, CRAE, London WC1H 0AA, England. [Pellicano, Elizabeth] Univ Western Australia, Sch Psychol, Perth, WA 6009, Australia. RP Pellicano, E (reprint author), Univ London, Inst Educ, Dept Psychol & Human Dev, CRAE, 25 Woburn Sq, London WC1H 0AA, England. EM l.pellicano@ioe.ac.uk FU British Academy; UK's Experimental Psychology Society; University College, Oxford; Clothworkers' Foundation; Pears Foundation FX This research was supported by the British Academy, the UK's Experimental Psychology Society and University College, Oxford. The author is extremely grateful to all the families who so generously took part in this work, to Alana Maley-Berg, Courtenay Norbury, and Simon Wallace for assistance with coding, and to Marc Stears for very helpful discussions. Research at CRAE is supported by The Clothworkers' Foundation and Pears Foundation. I have no conflicts of interests to declare. CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 Berger HJC, 2003, J CLIN EXP NEUROPSYC, V25, P502, DOI 10.1076/jcen.25.4.502.13870 BISHOP DVM, 1993, J CHILD PSYCHOL PSYC, V34, P279, DOI 10.1111/j.1469-7610.1993.tb00992.x Bloom P, 2000, COGNITION, V77, pB25, DOI 10.1016/S0010-0277(00)00096-2 Brown-Schmidt S, 2009, PSYCHON B REV, V16, P893, DOI 10.3758/PBR.16.5.893 Capps L., 1998, AUTISM, V2, P325, DOI DOI 10.1177/1362361398024002 Carlson SM, 2004, DEV PSYCHOL, V40, P1105, DOI 10.1037/0012-1649.40.6.1105 Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075 Coates S. W., 1972, MANUAL PRESCHOOL EMB DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777 Diamond A, 2007, SCIENCE, V318, P1387, DOI 10.1126/science.1151148 Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd Eaves LC, 2004, J AUTISM DEV DISORD, V34, P367, DOI 10.1023/B:JADD.0000037414.33270.a8 Elliott C. D., 1990, DIFFERENTIAL ABILITY FOMBONNE E, 1994, EUR CHILD ADOLES PSY, V3, P176 FRITH U, 1991, TRENDS NEUROSCI, V14, P433, DOI 10.1016/0166-2236(91)90041-R Frith U, 2010, PHILOS T R SOC B, V365, P165, DOI 10.1098/rstb.2009.0160 Glasson EJ, 2008, MED J AUSTRALIA, V188, P288 Gotham K., 2009, J AUTISM DEV DISORD, V39, P593 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Griffith EM, 1999, CHILD DEV, V70, P817, DOI 10.1111/1467-8624.00059 Hammill DD, 1993, DEV TEST VISUAL PERC Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 Harris P. L., 2000, UNDERSTANDING OTHER, P182 Hughes C, 1996, J CHILD PSYCHOL PSYC, V37, P229, DOI 10.1111/j.1469-7610.1996.tb01396.x Hughes C, 1998, DEV PSYCHOL, V34, P1326, DOI 10.1037/0012-1649.34.6.1326 Hughes C, 2004, SOC DEV, V13, P590, DOI 10.1111/j.1467-9507.2004.00285.x JARROLD C, 1994, J CHILD PSYCHOL PSYC, V35, P1473, DOI 10.1111/j.1469-7610.1994.tb01288.x Joseph RM, 2004, DEV PSYCHOPATHOL, V16, P137, DOI 10.1017/S095457940404444X Karmiloff-Smith A, 2009, DEV PSYCHOL, V45, P56, DOI 10.1037/a0014506 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 Lopez B. R., 2005, J AUTISM DEV DISORD, V35, P245 Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694 Lord C., 1999, ADOS AUTISM DIAGNOST LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Luria A. R., 1966, HIGHER CORTICAL FUNC MCEVOY RE, 1993, J CHILD PSYCHOL PSYC, V34, P563, DOI 10.1111/j.1469-7610.1993.tb01036.x Moses LJ, 2001, CHILD DEV, V72, P688, DOI 10.1111/1467-8624.00306 Mundy P, 2003, J CHILD PSYCHOL PSYC, V44, P793, DOI 10.1111/1469-7610.00165 Pellicano E, 2010, DEV PSYCHOL, V46, P530, DOI 10.1037/a0018287 Pellicano E., 2012, AUTISM RES TREATMENT, V2012, DOI 10.1155/2012/146132 Pellicano E, 2010, CHILD DEV, V81, P1400, DOI 10.1111/j.1467-8624.2010.01481.x Pellicano E, 2012, AJIDD-AM J INTELLECT, V117, P156, DOI 10.1352/1944-7558-117.2.156 Pellicano E, 2006, DEV PSYCHOPATHOL, V18, P77, DOI 10.1017/S0954579406060056 PERNER J, 1987, BRIT J DEV PSYCHOL, V5, P125 Riggs NR, 2006, J APPL DEV PSYCHOL, V27, P300, DOI 10.1016/j.appdev.2006.04.002 Roid G., 1997, LEITER INT PERFORMAN Russell J., 1997, AUTISM EXECUTIVE DIS, P215 Rutherford MD, 2003, J AUTISM DEV DISORD, V33, P289, DOI 10.1023/A:1024406601334 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x SHALLICE T, 1982, PHILOS T ROY SOC B, V298, P199, DOI 10.1098/rstb.1982.0082 Sinclair J., 1999, WHY I DISLIKE PERSON South M., 2007, AUTISM, V11, P441 SZATMARI P, 1989, J AUTISM DEV DISORD, V19, P213, DOI 10.1007/BF02211842 Tager-Flusberg H., 2003, INDIVIDUAL DIFFERENC, P197 Tager-Flusberg H, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P173 Travis L, 2001, J AUTISM DEV DISORD, V31, P119, DOI 10.1023/A:1010705912731 Turner L, 2006, AUTISM, V10, P257, DOI DOI 10.1177/1362361306063296 Turner M. A., 1997, AUTISM EXECUTIVE DIS, P57 Turner M. A., 1996, THESIS U CAMBRIDGE Wechsler D., 1989, WECHSLER PRESCHOOL P WIMMER H, 1983, COGNITION, V13, P103, DOI 10.1016/0010-0277(83)90004-5 Witkin HA, 1971, MANUAL EMBEDDED FIGU NR 67 TC 5 Z9 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2013 VL 6 IS 4 BP 258 EP 267 DI 10.1002/aur.1286 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 200ZY UT WOS:000323111700004 PM 23495146 ER PT J AU Urraca, N Cleary, J Brewer, V Pivnick, EK McVicar, K Thibert, RL Schanen, NC Esmer, C Lamport, D Reiter, LT AF Urraca, Nora Cleary, Julie Brewer, Victoria Pivnick, Eniko K. McVicar, Kathryn Thibert, Ronald L. Schanen, N. Carolyn Esmer, Carmen Lamport, Dustin Reiter, Lawrence T. TI The Interstitial Duplication 15q11.2-q13 Syndrome Includes Autism, Mild Facial Anomalies and a Characteristic EEG Signature SO AUTISM RESEARCH LA English DT Article DE autism; 15q duplication; imprinting; copy number variation; UBE3A ID DE-NOVO MUTATIONS; PERVASIVE DEVELOPMENTAL DISORDERS; SLEEP HABITS QUESTIONNAIRE; PRADER-WILLI-SYNDROME; SPECTRUM DISORDERS; ANGELMAN-SYNDROME; PROXIMAL 15Q; LINKAGE-DISEQUILIBRIUM; RECEPTOR SUBTYPES; REGION AB Chromosomal copy number variants (CNV) are the most common genetic lesion found in autism. Many autism-associated CNVs are duplications of chromosome 15q. Although most cases of interstitial (int) dup(15) that present clinically are de novo and maternally derived or inherited, both pathogenic and unaffected paternal duplications of 15q have been identified. We performed a phenotype/genotype analysis of individuals with interstitial 15q duplications to broaden our understanding of the 15q syndrome and investigate the contribution of 15q duplication to increased autism risk. All subjects were recruited solely on the basis of interstitial duplication 15q11.2-q13 status. Comparative array genome hybridization was used to determine the duplication size and boundaries while the methylation status of the maternally methylated small nuclear ribonucleoprotein polypeptide N gene was used to determine the parent of origin of the duplication. We determined the duplication size and parental origin for 14 int dup(15) subjects: 10 maternal and 4 paternal cases. The majority of int dup(15) cases recruited were maternal in origin, most likely due to our finding that maternal duplication was coincident with autism spectrum disorder. The size of the duplication did not correlate with the severity of the phenotype as established by Autism Diagnostic Observation Scale calibrated severity score. We identified phenotypes not comprehensively described before in this cohort including mild facial dysmorphism, sleep problems and an unusual electroencephalogram variant. Our results are consistent with the hypothesis that the maternally expressed ubiquitin protein ligase E3A gene is primarily responsible for the autism phenotype in int dup(15) since all maternal cases tested presented on the autism spectrum. (C) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Urraca, Nora; Reiter, Lawrence T.] Univ Tennessee, Ctr Hlth Sci, Dept Neurol, Memphis, TN 38163 USA. [Brewer, Victoria; Pivnick, Eniko K.; McVicar, Kathryn; Reiter, Lawrence T.] Univ Tennessee, Ctr Hlth Sci, Dept Pediat, Memphis, TN 38163 USA. [Cleary, Julie] Univ Memphis, Dept Speech & Language Pathol, Memphis, TN 38152 USA. [Thibert, Ronald L.] Mass Gen Hosp, Dept Neurol, Boston, MA USA. [Schanen, N. Carolyn] Nemours Biomed Res, Human Genet Res Lab, Wilmington, DE USA. [Esmer, Carmen] Hosp Cent Dr Ignacio Morones Prieto, Dept Genet, San Luis Potosi, Mexico. [Lamport, Dustin] Univ S Alabama, Dept Psychol, Mobile, AL 36688 USA. [Pivnick, Eniko K.] Univ Tennessee, Ctr Hlth Sci, Dept Ophthalmol, Memphis, TN 38163 USA. RP Reiter, LT (reprint author), Univ Tennessee, Ctr Hlth Sci, Dept Neurol, 855 Monroe Ave,Link 415, Memphis, TN 38163 USA. EM lreiter@uthsc.edu FU Herbert and Mary Shainberg Neuroscience Fund; Le Bonheur Children's Foundation FX This work was funded by a grant from the Herbert and Mary Shainberg Neuroscience Fund to L.T.R. and additional support from the Le Bonheur Children's Foundation to N.U. The authors would like to thank Edwin Cook for his insightful critical review of the manuscript as well as the Dup15q Alliance and all of the families who participated in this study. CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Autism and Developmental Disabilities Monitoring Network (ADDM), 2012, MMWR SURVEILL SUMM, V61, P1 Battaglia A, 2008, ORPHANET J RARE DIS, V3, DOI 10.1186/1750-1172-3-30 Battaglia A, 2005, BRAIN DEV-JPN, V27, P365, DOI 10.1016/j.braindev.2004.08.006 Bolton PF, 2001, AM J MED GENET, V105, P675, DOI 10.1002/ajmg.1551 Bolton PF, 2004, PSYCHIAT GENET, V14, P131, DOI 10.1097/00041444-200409000-00002 Browne CE, 1997, AM J HUM GENET, V61, P1342, DOI 10.1086/301624 BROWNE TR, 1973, EPILEPSIA, V14, P277, DOI 10.1111/j.1528-1157.1973.tb03965.x Buiting K, 2010, AM J MED GENET C, V154C, P365, DOI 10.1002/ajmg.c.30273 Cassidy SB, 1997, J MED GENET, V34, P917, DOI 10.1136/jmg.34.11.917 CLAYTONSMITH J, 1993, J MED GENET, V30, P529, DOI 10.1136/jmg.30.6.529 Cohen D, 2007, J AUTISM DEV DISORD, V37, P1585, DOI 10.1007/s10803-006-0228-5 Cook EH, 1998, AM J HUM GENET, V62, P1077, DOI 10.1086/301832 Cook EH, 1997, AM J HUM GENET, V60, P928 Couturier JL, 2005, J AM ACAD CHILD PSY, V44, P815, DOI 10.1097/01.chi.0000166377.22651.87 Depienne C, 2009, BIOL PSYCHIAT, V66, P349, DOI 10.1016/j.biopsych.2009.01.025 Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002 Dindot SV, 2008, HUM MOL GENET, V17, P111, DOI 10.1093/hmg/ddm288 DuBose AJ, 2010, NEUROGENETICS, V11, P145, DOI 10.1007/s10048-009-0226-9 Dunn L. M., 2007, PEABODY PICTURE VOCA Fantes JA, 2002, J MED GENET, V39, P170, DOI 10.1136/jmg.39.3.170 Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Guffanti G, 2011, PSYCHIAT RES, V185, P33, DOI 10.1016/j.psychres.2010.04.057 Halleck MS, 1999, PHYSIOL GENOMICS, V1, P139 Herzing LBK, 2001, AM J HUM GENET, V68, P1501, DOI 10.1086/320616 Hogart A, 2007, HUM MOL GENET, V16, P691, DOI 10.1093/hmg/ddm014 Hogart A, 2008, HUM GENET, V124, P235, DOI 10.1007/s00439-008-0546-0 Hogart A, 2010, NEUROBIOL DIS, V38, P181, DOI 10.1016/j.nbd.2008.08.011 Krakowiak P, 2008, J SLEEP RES, V17, P197, DOI 10.1111/j.1365-2869.2008.00650.x LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Malow BA, 2009, J CHILD NEUROL, V24, P19, DOI 10.1177/0883073808321044 Mao R, 2000, GENET MED, V2, P131, DOI 10.1097/00125817-200003000-00003 Marshall CR, 2012, METHODS MOL BIOL, V838, P115, DOI 10.1007/978-1-61779-507-7_5 Miles JH, 2011, GENET MED, V13, P278, DOI 10.1097/GIM.0b013e3181ff67ba Mohandas TK, 1999, AM J MED GENET, V82, P294, DOI 10.1002/(SICI)1096-8628(19990212)82:4<294::AID-AJMG4>3.0.CO;2-U Moreno Duilio Prado, 2012, P1 Nurmi EL, 2001, GENOMICS, V77, P105, DOI 10.1006/geno.2001.6617 O'Roak BJ, 2012, NATURE, V485, P246, DOI 10.1038/nature10989 O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835 Orrico A, 2009, AM J MED GENET A, V149A, P1033, DOI 10.1002/ajmg.a.32785 Owens JA, 2000, SLEEP, V23, P1043 Peters SU, 2012, J CHILD PSYCHOL PSYC, V53, P152, DOI 10.1111/j.1469-7610.2011.02455.x Roberts SE, 2002, HUM GENET, V110, P227, DOI 10.1007/s00439-001-0678-6 Rudolph U, 1999, NATURE, V401, P796, DOI 10.1038/44579 Rudolph U, 2011, NAT REV DRUG DISCOV, V10, P685, DOI 10.1038/nrd3502 Sanders SJ, 2012, NATURE, V485, P237, DOI 10.1038/nature10945 Scoles HA, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-19 SPARROW SS, 1985, J PEDIATR PSYCHOL, V10, P215, DOI 10.1093/jpepsy/10.2.215 Stankiewicz P, 2010, ANNU REV MED, V61, P437, DOI 10.1146/annurev-med-100708-204735 Stephens SH, 2009, SCHIZOPHR RES, V109, P102, DOI 10.1016/j.schres.2008.12.017 Szafranski P, 2010, HUM MUTAT, V31, P840, DOI 10.1002/humu.21284 Urraca N, 2010, GENET TEST MOL BIOMA, V14, P571, DOI 10.1089/gtmb.2010.0030 Vaags AK, 2012, AM J HUM GENET, V90, P133, DOI 10.1016/j.ajhg.2011.11.025 Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050 Veltman MWM, 2005, J AUTISM DEV DISORD, V35, P117, DOI 10.1007/s10803-004-1039-1 Vorstman JAS, 2006, MOL PSYCHIATR, V11, P18, DOI 10.1038/sj.mp.4001757 NR 57 TC 14 Z9 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2013 VL 6 IS 4 BP 268 EP 279 DI 10.1002/aur.1284 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 200ZY UT WOS:000323111700005 PM 23495136 ER PT J AU Zaki, SR Johnson, SA AF Zaki, Safa R. Johnson, Shannon A. TI The Role of Gaze Direction in Face Memory in Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; face recognition; eye-contact; face-processing; gaze ID OBJECT RECOGNITION; EYE REMEMBER; CHILDREN; FIXATION; PROSOPAGNOSIA; PERCEPTION; RESPONSES; BEHAVIOR AB We tested the hypothesis that the direction of gaze of target faces may play a role in reported face recognition deficits in those with an autism spectrum disorder (ASD). In previous studies, typically developing children and adults better remembered faces in which the eyes were gazing directly at them compared with faces in which the eyes were averted. In the current study, high-functioning children and adolescents with an ASD and age- and IQ-matched typically developing controls were shown a series of pictures of faces in a study phase. These pictures were of individuals whose gaze was either directed straight ahead or whose gaze was averted to one side. We tested the memory for these study faces in a recognition task in which the faces were shown with their eyes closed. The typically developing group better remembered the direct-gaze faces, whereas the ASD participants did not show this effect. These results imply that there may be an important link between gaze direction and face recognition abilities in ASD. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Zaki, Safa R.] Williams Coll, Williamstown, MA 01267 USA. [Johnson, Shannon A.] Dalhousie Univ, Halifax, NS, Canada. RP Zaki, SR (reprint author), Williams Coll, Bronfman Sci Ctr, Dept Psychol, Williamstown, MA 01267 USA. EM szaki@williams.edu FU IWK Health Centre, Halifax, Nova Scotia, Canada FX This research was supported by a Category B grant from the IWK Health Centre, Halifax, Nova Scotia, Canada to Shannon Johnson and Safa Zaki. Correspondence should be addressed to Safa Zaki, Psychology Department, Williams College, Williamstown, MA 10267. CR BARONCOHEN S, 1995, BRIT J DEV PSYCHOL, V13, P379 Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 Creelman C. D., 1991, DETECTION THEORY USE Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6 Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433 Duchaine BC, 2000, NEUROREPORT, V11, P79, DOI 10.1097/00001756-200001170-00016 Farah MJ, 2000, COGNITIVE NEUROPSYCH, V17, P117, DOI 10.1080/026432900380526 FARAH MJ, 1995, NEUROPSYCHOLOGIA, V33, P661, DOI 10.1016/0028-3932(95)00002-K Farah MJ, 1996, BEHAV BRAIN RES, V76, P181, DOI 10.1016/0166-4328(95)00198-0 Frith U., 2003, AUTISM EXPLAINING EN Gauthier I, 2000, NAT NEUROSCI, V3, P191, DOI 10.1038/72140 Gauthier I, 1999, J COGNITIVE NEUROSCI, V11, P349, DOI 10.1162/089892999563472 Gauthier I, 2002, J EXP PSYCHOL HUMAN, V28, P431, DOI 10.1037//0096-1523.28.2.431 Goodman LR, 2012, MEMORY, V20, P199, DOI 10.1080/09658211.2011.651089 Green D. M., 1966, SIGNAL DETECTION THE Grelotti DJ, 2002, DEV PSYCHOBIOL, V40, P213, DOI 10.1002/dev.10028 Henderson JM, 2005, MEM COGNITION, V33, P98, DOI 10.3758/BF03195300 HOOD B, 2007, LOOK MY EYES EFFECT, P283 Hood BM, 2003, DEVELOPMENTAL SCI, V6, P67, DOI 10.1111/1467-7687.00256 Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5 Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344 Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 Kylliainen A, 2006, EUR J NEUROSCI, V24, P2679, DOI 10.1111/j.1460-9568.2006.05132.x Kylliainen A, 2006, J AUTISM DEV DISORD, V36, P517, DOI 10.1007/s10803-006-0091-4 Lord C., 2008, AUTISM DIAGNOSTIC OB Mason MF, 2004, MEMORY, V12, P637, DOI 10.1080/09658210344000152 OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225 Pellicano E, 2009, PSYCHON B REV, V16, P1094, DOI 10.3758/PBR.16.6.1094 Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369 Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7 Rutter M., 2003, AUTISM DIAGNOSTIC IN Sasson NJ, 2006, J AUTISM DEV DISORD, V36, P381, DOI 10.1007/s10803-006-0076-3 Senju A, 2009, NEUROSCI BIOBEHAV R, V33, P1204, DOI 10.1016/j.neubiorev.2009.06.001 Senju A, 2008, BRAIN COGNITION, V67, P127, DOI 10.1016/j.bandc.2007.12.001 Smith AD, 2006, DEVELOPMENTAL SCI, V9, P465, DOI 10.1111/j.1467-7687.2006.00513.x Tanaka J. W., 1997, PSYCHOL LEARN MOTIV, V36, P83, DOI 10.1016/S0079-7421(08)60282-0 van der Geest JN, 2002, J CHILD PSYCHOL PSYC, V43, P669, DOI 10.1111/1469-7610.00055 Wechsler D, 1999, WECHSLER ABBREVIATED Wickens Thomas, 2002, ELEMENTARY SIGNAL DE NR 42 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2013 VL 6 IS 4 BP 280 EP 287 DI 10.1002/aur.1292 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 200ZY UT WOS:000323111700006 PM 23512772 ER PT J AU Williams, DL Cherkassky, VL Mason, RA Keller, TA Minshew, NJ Just, MA AF Williams, Diane L. Cherkassky, Vladimir L. Mason, Robert A. Keller, Timothy A. Minshew, Nancy J. Just, Marcel Adam TI Brain Function Differences in Language Processing in Children and Adults with Autism SO AUTISM RESEARCH LA English DT Article DE fMRI; language processing; development; functional connectivity ID SENTENCE COMPREHENSION; SPECTRUM DISORDERS; LEARNING-DISABILITIES; RIGHT-HEMISPHERE; MIND REGIONS; WHITE-MATTER; FMRI; ACTIVATION; CONNECTIVITY; ADOLESCENTS AB Comparison of brain function between children and adults with autism provides an understanding of the effects of the disorder and associated maturational differences on language processing. Functional imaging (functional magnetic resonance imaging) was used to examine brain activation and cortical synchronization during the processing of literal and ironic texts in 15 children with autism, 14 children with typical development, 13 adults with autism, and 12 adult controls. Both the children and adults with autism had lower functional connectivity (synchronization of brain activity among activated areas) than their age and ability comparison group in the left hemisphere language network during irony processing, and neither autism group had an increase in functional connectivity in response to increased task demands. Activation differences for the literal and irony conditions occurred in key language-processing regions (left middle temporal, left pars triangularis, left pars opercularis, left medial frontal, and right middle temporal). The children and adults with autism differed from each other in the use of some brain regions during the irony task, with the adults with autism having activation levels similar to those of the control groups. Overall, the children and adults with autism differed from the adult and child controls in (a) the degree of network coordination, (b) the distribution of the workload among member nodes, and (3) the dynamic recruitment of regions in response to text content. Moreover, the differences between the two autism age groups may be indicative of positive changes in the neural function related to language processing associated with maturation and/or educational experience. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Williams, Diane L.] Duquesne Univ, Dept Speech Language Pathol, Pittsburgh, PA 15219 USA. [Williams, Diane L.; Cherkassky, Vladimir L.; Mason, Robert A.; Keller, Timothy A.; Just, Marcel Adam] Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA. [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA. [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA. RP Williams, DL (reprint author), Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, 5000 Forbes Ave, Pittsburgh, PA 15213 USA. EM diane72@andrew.cmu.edu FU National Institute of Child Health and Human Development [HD055748, U19HD35469]; National Institute of Deafness and Other Communication [K23 DC00669] FX Grant Sponsor: National Institute of Child Health and Human Development.Grant Numbers: Autism Center of Excellence HD055748; Collaborative Programs of Excellence in Autism U19HD35469Grant Sponsor: National Institute of Deafness and Other CommunicationGrant Number: K23 DC00669 [to DLW] CR BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 Blumenfeld HK, 2006, BRAIN LANG, V99, P226, DOI 10.1016/j.bandl.2005.07.004 Booth JR, 2004, J COGNITIVE NEUROSCI, V16, P1234, DOI 10.1162/0898929041920496 Carrington SJ, 2009, HUM BRAIN MAPP, V30, P2313, DOI 10.1002/hbm.20671 Casanova MF, 2002, NEUROLOGY, V58, P428 Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5 Chou TL, 2006, NEUROIMAGE, V29, P1141, DOI 10.1016/j.neuroimage.2005.09.064 Colich NL, 2012, METAPHOR SYMBOL, V27, P70, DOI 10.1080/10926488.2012.638856 Diwadkar VA, 2000, NEUROIMAGE, V12, P85, DOI 10.1006/nimg.2000.0586 Ecker C, 2012, ARCH GEN PSYCHIAT, V69, P195, DOI 10.1001/archgenpsychiatry.2011.1251 Eviatar Z, 2006, NEUROPSYCHOLOGIA, V44, P2348, DOI 10.1016/j.neuropsychologia.2006.05.007 Ferstl EC, 2008, HUM BRAIN MAPP, V29, P581, DOI 10.1002/hbm.20422 Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083 Friederici AD, 2000, CEREB CORTEX, V10, P698, DOI 10.1093/cercor/10.7.698 Friston KJ, 1995, HUM BRAIN MAPP, V3, P165, DOI 10.1002/hbm.460030303 Frith U, 2003, PHILOS T R SOC B, V358, P459, DOI 10.1098/rstb.2002.1218 Giora R, 2012, METAPHOR SYMBOL, V27, P22, DOI 10.1080/10926488.2012.638823 Groen WB, 2010, CEREB CORTEX, V20, P1937, DOI 10.1093/cercor/bhp264 Hampson M, 2002, HUM BRAIN MAPP, V15, P247, DOI 10.1002/hbm.10022 Harris GJ, 2006, BRAIN COGNITION, V61, P54, DOI 10.1016/j.bandc.2005.12.015 Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032 Hirshorn EA, 2006, NEUROPSYCHOLOGIA, V44, P2547, DOI 10.1016/j.neuropsychologia.2006.03.035 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kana RK, 2009, SOC NEUROSCI-UK, V4, P135, DOI 10.1080/17470910802198510 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004 Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99 Knaus TA, 2008, J INT NEUROPSYCH SOC, V14, P967, DOI 10.1017/S1355617708081216 Knaus TA, 2009, BRAIN IMAGING BEHAV, V3, P51, DOI 10.1007/s11682-008-9048-x Kumar A, 2010, CEREB CORTEX, V20, P2103, DOI 10.1093/cercor/bhp278 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030 Mar RA, 2011, ANNU REV PSYCHOL, V62, P103, DOI 10.1146/annurev-psych-120709-145406 Mashal N, 2011, RES DEV DISABIL, V32, P2045, DOI 10.1016/j.ridd.2011.08.012 Mashal N, 2012, RES DEV DISABIL, V33, P274, DOI 10.1016/j.ridd.2011.09.010 Mason RA, 2011, HUM BRAIN MAPP, V32, P313, DOI 10.1002/hbm.21021 Mason RA, 2008, NEUROPSYCHOLOGIA, V46, P269, DOI 10.1016/j.neuropsychologia.2007.07.018 Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018 Prat CS, 2007, J COGNITIVE NEUROSCI, V19, P1950, DOI 10.1162/jocn.2007.19.12.1950 Reitan R.M., 1985, HALSTEAD REITAN NEUR Sachs Bonnie C, 2003, Curr Neurol Neurosci Rep, V3, P157, DOI 10.1007/s11910-003-0068-z Sahyoun CP, 2010, NEUROPSYCHOLOGIA, V48, P86, DOI 10.1016/j.neuropsychologia.2009.08.013 Sandak R, 2004, COGN AFFECT BEHAV NE, V4, P67, DOI 10.3758/CABN.4.1.67 Schipul SE, 2011, FRONTIERS SYSTEMS NE, V5, P1, DOI DOI 10.3389/FNSYS.2011.00010 Sperber D., 1995, RELEVANCE COMMUNICAT Sperber D., 1981, RADICAL PRAGMATICS, P295 Tesink CMJY, 2009, BRAIN, V132, P1941, DOI 10.1093/brain/awp103 Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978 Vigneau M, 2011, NEUROIMAGE, V54, P577, DOI 10.1016/j.neuroimage.2010.07.036 Wang AT, 2006, BRAIN, V129, P932, DOI 10.1093/brain/awl032 Wechsler D, 1999, WECHSLER ABBREVIATED NR 52 TC 7 Z9 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2013 VL 6 IS 4 BP 288 EP 302 DI 10.1002/aur.1291 PG 15 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 200ZY UT WOS:000323111700007 PM 23495230 ER PT J AU Harrington, RA Lee, LC Crum, RM Zimmerman, AW Hertz-Picciotto, I AF Harrington, Rebecca A. Lee, Li-Ching Crum, Rosa M. Zimmerman, Andrew W. Hertz-Picciotto, Irva TI Serotonin Hypothesis of Autism: Implications for Selective Serotonin Reuptake Inhibitor Use during Pregnancy SO AUTISM RESEARCH LA English DT Review DE autism spectrum disorders; serotonin; selective serotonin reuptake inhibitors; pregnancy ID PERSISTENT PULMONARY-HYPERTENSION; PERVASIVE DEVELOPMENTAL DISORDERS; IN-UTERO EXPOSURE; PRENATAL ANTIDEPRESSANT EXPOSURE; WHOLE-BLOOD SEROTONIN; SPECTRUM DISORDERS; MONOAMINE-OXIDASE; PLATELET SEROTONIN; TRANSPORTER GENE; PSYCHIATRIC-DISORDERS AB Serotonin, a neurotransmitter found throughout the brain and body, has long been of interest in autism. Repeated findings of elevated platelet serotonin levels in approximately one third of children with autism has led some to believe that dysfunctional serotonin signaling may be a causal mechanism for the disorder. Because serotonin is critical to fetal brain development, concerns have arisen regarding prenatal exposure to substances that manipulate serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs). This review examines evidence regarding the serotonin system and autism spectrum disorders (ASD), as well as what the literature has reported thus far on developmental effects of prenatal exposure to SSRIs. Possible mechanisms by which SSRIs could affect the fetus during pregnancy and clinical implications are also discussed. Though the majority of studies conducted in infants and children suggest prenatal exposure to SSRIs does not affect neurodevelopment, interpretation must be tempered given small sample sizes. The only published study that focused on prenatal SSRI exposure and ASD found an increased risk with exposure to SSRIs, especially during the first trimester. Obstacles that will be faced in future research are isolating medication effects from maternal depression and, given the infrequent occurrence of exposure and outcome, obtaining an adequate sample size. Whether serotonin is an etiologic factor in ASD, and what it points to as a marker for subgrouping, remains unclear. Understanding how the development of ASD might be affected by prenatal factors that influence serotonin levels, such as SSRIs, could identify modifiable targets for prevention. Autism Res 2013, 6: 149-168. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Harrington, Rebecca A.; Lee, Li-Ching] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Crum, Rosa M.] Johns Hopkins Med Inst, Dept Epidemiol, Baltimore, MD 21205 USA. [Crum, Rosa M.] Johns Hopkins Med Inst, Dept Psychiat, Baltimore, MD 21205 USA. [Crum, Rosa M.] Johns Hopkins Med Inst, Dept Mental Hlth, Baltimore, MD 21205 USA. [Zimmerman, Andrew W.] Massachusetts Gen Hosp Children, Lurie Ctr Autism, Lexington, MA USA. [Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA. [Hertz-Picciotto, Irva] Univ Calif Davis, MIND Inst, MS1C, Davis, CA 95616 USA. RP Harrington, RA (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 N Wolfe St,Suite E6037, Baltimore, MD 21205 USA. EM rharring@jhsph.edu CR Abbott NJ, 2006, NAT REV NEUROSCI, V7, P41, DOI 10.1038/nrn1824 Abbott NJ, 2010, NEUROBIOL DIS, V37, P13, DOI 10.1016/j.nbd.2009.07.030 Alwan S, 2007, NEW ENGL J MED, V356, P2684, DOI 10.1056/NEJMoa066584 Alwan S, 2011, J CLIN PHARMACOL, V51, P264, DOI 10.1177/0091270010373928 ANDERSON GM, 1987, MED BIOL, V65, P67 Anderson GM, 2004, PEDIATR RES, V56, P418, DOI 10.1203/01.PDR.0000136278.23672.A0 Anderson GM, 2007, PEDIATR NEUROL, V36, P138, DOI 10.1016/j.pediatrneurol.2006.11.007 ANDERSON GM, 1987, J CHILD PSYCHOL PSYC, V28, P885, DOI 10.1111/j.1469-7610.1987.tb00677.x ANDERSON GM, 1990, ANN NY ACAD SCI, V600, P331, DOI 10.1111/j.1749-6632.1990.tb16893.x Anderson GM, 2002, J AM ACAD CHILD PSY, V41, P1513, DOI 10.1097/01.CHI.0000024874.60748.28 Andersson L, 2006, ACTA OBSTET GYN SCAN, V85, P937, DOI 10.1080/00016340600697652 Andrade SE, 2008, AM J OBSTET GYNECOL, V198, DOI DOI 10.1016/J.AJ0G.2007.07.036 Andrade SE, 2009, PHARMACOEPIDEM DR S, V18, P246, DOI 10.1002/pds.1710 Ansorge MS, 2007, CURR OPIN PHARMACOL, V7, P8, DOI 10.1016/j.coph.2006.11.006 Arieff Z, 2010, HUM BIOL, V82, P291, DOI 10.3378/027.082.0303 Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators, 2012, SURVEILL SUMM, V61, P1 Bakker MK, 2008, BRIT J CLIN PHARMACO, V65, P600, DOI 10.1111/j.1365-2125.2007.03048.x Bale TL, 2010, BIOL PSYCHIAT, V68, P314, DOI 10.1016/j.biopsych.2010.05.028 BALKOVETZ DF, 1989, J BIOL CHEM, V264, P2195 Benes FM, 2000, CEREB CORTEX, V10, P1014, DOI 10.1093/cercor/10.10.1014 Berger M, 2009, ANNU REV MED, V60, P355, DOI 10.1146/annurev.med.60.042307.110802 Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078 Bonari L, 2004, CAN J PSYCHIAT, V49, P726 Bonnin A, 2011, NATURE, V472, P347, DOI 10.1038/nature09972 Borue X, 2007, INT J DEV NEUROSCI, V25, P341, DOI 10.1016/j.ijdevneu.2007.06.003 Boylan CB, 2007, BEHAV BRAIN RES, V176, P94, DOI 10.1016/j.bbr.2006.08.026 Brodkin ES, 1997, J CHILD ADOL PSYCHOP, V7, P109, DOI 10.1089/cap.1997.7.109 Bromley RL, 2008, NEUROLOGY, V71, P1923, DOI 10.1212/01.wnl.0000339399.64213.1a Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C Cabrera-Vera TM, 2000, BRAIN RES, V870, P1, DOI 10.1016/S0006-8993(00)02382-9 Casper RC, 2011, PSYCHOPHARMACOLOGY, V217, P211, DOI 10.1007/s00213-011-2270-z Casper RC, 2003, J PEDIATR-US, V142, P402, DOI 10.1067/mpd.203.139 Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968 Chambers CD, 2006, NEW ENGL J MED, V354, P579, DOI 10.1056/NEJMoa052744 Christensen HD, 2000, NEUROTOXICOL TERATOL, V22, P733, DOI 10.1016/S0892-0362(00)00099-4 Chugani DC, 1997, ANN NEUROL, V42, P666, DOI 10.1002/ana.410420420 Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9 Cohen IL, 2011, CLIN GENET, V79, P355, DOI 10.1111/j.1399-0004.2010.01471.x Cohen IL, 2003, CLIN GENET, V64, P190, DOI 10.1034/j.1399-0004.2003.00115.x Cohen IL, 2010, J AUTISM DEV DISORD, V40, P599, DOI 10.1007/s10803-009-0908-z Cohen LS, 2006, JAMA-J AM MED ASSOC, V295, P499, DOI 10.1001/jama.295.5.499 Connors SL, 2006, PEDIATR NEUROL, V35, P182, DOI 10.1016/j.pediatrneurol.2006.02.010 Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008 COOL DR, 1990, AM J PHYSIOL, V259, pC196 COOL DR, 1990, BIOCHEM PHARMACOL, V40, P2161, DOI 10.1016/0006-2952(90)90249-K Cooper WO, 2007, AM J OBSTET GYNECOL, V196, P544, DOI 10.1016/j.ajog.2007.01.033 Cote F, 2007, P NATL ACAD SCI USA, V104, P329, DOI 10.1073/pnas.0606722104 Coutinho AM, 2007, HUM GENET, V121, P243, DOI 10.1007/s00439-006-0301-3 Croen LA, 2011, ARCH GEN PSYCHIAT, V68, P1104, DOI 10.1001/archgenpsychiatry.2011.73 Croonenberghs J, 2005, LIFE SCI, V76, P2171, DOI 10.1016/j.lfs.2004.06.032 Daneman R, 2010, NATURE, V468, P562, DOI 10.1038/nature09513 Daubert EA, 2010, TRENDS NEUROSCI, V33, P424, DOI 10.1016/j.tins.2010.05.005 Deave T, 2008, BJOG-INT J OBSTET GY, V115, P1043, DOI 10.1111/j.1471-0528.2008.01752.x DeLong R, 2004, J NEUROPSYCH CLIN N, V16, P199, DOI 10.1176/appi.neuropsych.16.2.199 Devlin B, 2005, MOL PSYCHIATR, V10, P1110, DOI 10.1038/sj.mp.4001724 Dietz PM, 2007, AM J PSYCHIAT, V164, P1515, DOI 10.1176/appi.ajp.2007.06111893 Dufour-Rainfray D, 2011, NEUROSCI BIOBEHAV R, V35, P1254, DOI 10.1016/j.neubiorev.2010.12.013 Einarson A, 2008, AM J PSYCHIAT, V165, P749, DOI 10.1176/appi.ajp.2007.07060879 TOTH G, 1986, Acta Paediatrica Hungarica, V27, P221 Ferreira E, 2007, PEDIATRICS, V119, P52, DOI 10.1542/peds.2006-2133 Frodl T, 2008, MOL PSYCHIATR, V13, P1093, DOI 10.1038/mp.2008.62 Galbally M, 2011, AUST NZ J PSYCHIAT, V45, P393, DOI 10.3109/00048674.2010.549995 Gaspar P, 2003, NAT REV NEUROSCI, V4, P1002, DOI 10.1038/nrn1256 Gentile S, 2007, ARCH WOMEN MENT HLTH, V10, P39, DOI 10.1007/s00737-007-0173-0 Gentile S, 2009, J CLIN PSYCHIAT, V70, P414 Giannaccini G, 2010, NEUROCHEM RES, V35, P628, DOI 10.1007/s11064-009-0112-8 GILLBERG C, 1987, BRIT J PSYCHIAT, V151, P89, DOI 10.1192/bjp.151.1.89 Greenberg BD, 1999, AM J MED GENET, V88, P83, DOI 10.1002/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0 Hadjikhani N, 2010, MED HYPOTHESES, V74, P880, DOI 10.1016/j.mehy.2009.11.015 Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76 HANLEY HG, 1977, ARCH GEN PSYCHIAT, V34, P521 Hayes R. M., 2012, AM J OBSTET GYNECOLO, V207 HEDNER J, 1986, BIOL NEONATE, V49, P190 Heikkinen T, 2003, CLIN PHARMACOL THER, V73, P330, DOI 10.1016/S0009-9236(02)17634-X Heikkinen T, 2002, CLIN PHARMACOL THER, V72, P184, DOI 10.1067/mcp.2002.126181 Heils A, 1996, J NEUROCHEM, V66, P2621 Hendrick V, 2003, AM J PSYCHIAT, V160, P993, DOI 10.1176/appi.ajp.160.5.993 Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15 Hiemke C, 2000, PHARMACOL THERAPEUT, V85, P11, DOI 10.1016/S0163-7258(99)00048-0 Hilton CL, 2012, AUTISM, V16, P430, DOI 10.1177/1362361311423018 Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627 Hollander E, 2012, AM J PSYCHIAT, V169, P292, DOI 10.1176/appi.ajp.2011.10050764 Homberg JR, 2010, TRENDS PHARMACOL SCI, V31, P60, DOI 10.1016/j.tips.2009.11.003 Hranilovic D, 2007, J AUTISM DEV DISORD, V37, P1934, DOI 10.1007/s10803-006-0324-6 Hranilovic D, 2008, COLLEGIUM ANTROPOL, V32, P75 Il'kova G, 2004, ZYGOTE, V12, P205, DOI 10.1017/S0967199404002862 Johansson PA, 2008, BIOESSAYS, V30, P237, DOI 10.1002/bies.20718 Kallen B, 2008, PHARMACOEPIDEM DR S, V17, P801, DOI 10.1002/pds.1570 KIELER H, 2011, BMJ-BRIT MED J, V344, pD8012, DOI DOI 10.1136/BMJ.D8012 KIM CS, 1994, INT J DEV NEUROSCI, V12, P499, DOI 10.1016/0736-5748(94)90034-5 King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30 Kistner-Griffin E, 2011, AM J MED GENET B, V156B, P139, DOI 10.1002/ajmg.b.31146 KONTUR PJ, 1993, EXP NEUROL, V121, P172, DOI 10.1006/exnr.1993.1084 Krakowiak P, 2008, J SLEEP RES, V17, P197, DOI 10.1111/j.1365-2869.2008.00650.x Larson MJ, 2007, ADM POLICY MENT HLTH, V34, P116, DOI 10.1007/s10488-006-0088-5 Leboyer M, 1999, BIOL PSYCHIAT, V45, P158, DOI 10.1016/S0006-3223(97)00532-5 Levallois C, 1997, DEV BRAIN RES, V99, P243, DOI 10.1016/S0165-3806(97)00026-6 Levin M, 2006, DEV NEUROSCI-BASEL, V28, P171, DOI 10.1159/000091915 Lisboa SFS, 2007, PHARMACOLOGY, V80, P49, DOI 10.1159/000103097 Longo D, 2009, BRAIN RES, V1267, P9, DOI 10.1016/j.brainres.2009.02.072 Lorenzo L, 2011, EXPERT OPIN DRUG SAF, V10, P883, DOI 10.1517/14740338.2011.583917 Loughhead AM, 2006, AM J PSYCHIAT, V163, P145, DOI 10.1176/appi.ajp.163.1.145 Louik C, 2007, NEW ENGL J MED, V356, P2675, DOI 10.1056/NEJMoa067407 Maimburg RD, 2006, ACTA PSYCHIAT SCAND, V114, P257, DOI 10.1111/j.1600-0447.2006.00805.x Malm H, 2011, OBSTET GYNECOL, V118, P111, DOI 10.1097/AOG.0b013e318220edcc Marazziti D, 2000, PHARMACOPSYCHIATRY, V33, P165, DOI 10.1055/s-2000-7588 Mattson S. N., 1999, Teratology, V59, P376 McAllister BB, 2012, NEUROSCIENCE, V226, P356, DOI 10.1016/j.neuroscience.2012.09.024 McBride P. Anne, 1998, Journal of the American Academy of Child and Adolescent Psychiatry, V37, P767, DOI 10.1097/00004583-199807000-00017 McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P1001 McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P993 Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016 Meredith EJ, 2005, IMMUNOLOGY, V115, P289, DOI 10.1111/j.1365-2567.2005.02166.x Meyer JH, 2001, AM J PSYCHIAT, V158, P1843, DOI 10.1176/appi.ajp.158.11.1843 Meyer JH, 2004, AM J PSYCHIAT, V161, P826, DOI 10.1176/appi.ajp.161.5.826 Misri S, 2006, AM J PSYCHIAT, V163, P1026, DOI 10.1176/appi.ajp.163.6.1026 Mojtabai R, 2011, HEALTH AFFAIR, V30, P1434, DOI 10.1377/hlthaff.2010.1024 Morison Sara J., 2001, Pediatric Research, V49, p28A Mortensen JT, 2003, EUR J EPIDEMIOL, V18, P769 Moses-Kolko EL, 2005, JAMA-J AM MED ASSOC, V293, P2372, DOI 10.1001/jama.293.19.2372 Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0 Muneoka K, 1997, DEV BRAIN RES, V102, P117, DOI 10.1016/S0165-3806(97)00092-8 Nakhai-Pour HR, 2010, CAN MED ASSOC J, V182, P1031, DOI 10.1503/cmaj.091208 NARAYAN M, 1993, BIOL PSYCHIAT, V33, P630, DOI 10.1016/0006-3223(93)90102-J Nordeng H, 2012, J CLIN PSYCHOPHARM, V32, P186, DOI 10.1097/JCP.0b013e3182490eaf Nordquist N, 2010, UPSALA J MED SCI, V115, P2, DOI 10.3109/03009730903573246 Nulman I, 1997, NEW ENGL J MED, V336, P258, DOI 10.1056/NEJM199701233360404 Nulman I, 2002, AM J PSYCHIAT, V159, P1889, DOI 10.1176/appi.ajp.159.11.1889 Oberlander TF, 2007, ARCH PEDIAT ADOL MED, V161, P22, DOI 10.1001/archpedi.161.1.22 Oberlander TF, 2004, J CLIN PSYCHIAT, V65, P230 Oberlander TF, 2009, CLIN PHARMACOL THER, V86, P672, DOI 10.1038/clpt.2009.201 Oberlander TF, 2010, ARCH PEDIAT ADOL MED, V164, P444, DOI 10.1001/archpediatrics.2010.51 Olivier JDA, 2011, PROG NEURO-PSYCHOPH, V35, P1400, DOI 10.1016/j.pnpbp.2010.09.013 PASTUSZAK A, 1993, JAMA-J AM MED ASSOC, V269, P2246, DOI 10.1001/jama.269.17.2246 Pedersen LH, 2010, PEDIATRICS, V125, pE600, DOI 10.1542/peds.2008-3655 Petersen I, 2011, J CLIN PSYCHIAT, V72, P979, DOI 10.4088/JCP.10m06090blu Piven J, 1999, AM J PSYCHIAT, V156, P557 Preskorn S. H., 2004, ANTIDEPRESSANTS PRES, P242 Preskorn SH, 2012, J PSYCHIATR PRACT, V18, P38, DOI 10.1097/01.pra.0000410986.61593.46 Pytliak M, 2011, PHYSIOL RES, V60, P15 Ramoz N, 2006, BIOL PSYCHIAT, V60, P186, DOI 10.1016/j.biopsych.2006.01.009 Rampono J, 2009, PHARMACOPSYCHIATRY, V42, P95, DOI 10.1055/s-0028-1103296 Rayen I., 2011, PLOS ONE, V6 Reebye PN, 2002, INF MENTAL HLTH J, V23, P403, DOI 10.1002/imhj.10025 Reefhuis J, 2006, NEW ENGL J MED, V354, P2188 Rice C, 2010, DISABIL HEALTH J, V3, P186, DOI 10.1016/j.dhjo.2009.10.008 ROMIJN HJ, 1991, EARLY HUM DEV, V26, P61, DOI 10.1016/0378-3782(91)90044-4 Rurak D, 2011, PEDIATR RES, V70, P96, DOI 10.1038/pr.2011.321 Sabol SZ, 1998, HUM GENET, V103, P273, DOI 10.1007/s004390050816 Sari Y, 2001, J BIOMED SCI, V8, P119, DOI 10.1159/000054022 SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8 Schetter CD, 2012, CURR OPIN PSYCHIATR, V25, P141, DOI 10.1097/YCO.0b013e3283503680 Schmidt RJ, 2012, AM J CLIN NUTR, V96, P80, DOI 10.3945/ajcn.110.004416 Schmidt RJ, 2011, EPIDEMIOLOGY, V22, P476, DOI 10.1097/EDE.0b013e31821d0e30 Serfaty CA, 2008, NEUROIMMUNOMODULAT, V15, P170, DOI 10.1159/000153421 SHEN WZ, 1989, PEDIATR NEUROSCI, V15, P291, DOI 10.1159/000120485 Simon GE, 2002, AM J PSYCHIAT, V159, P2055, DOI 10.1176/appi.ajp.159.12.2055 Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f Sivasubramaniam SD, 2002, PLACENTA, V23, P163, DOI 10.1053/plac.2001.0770 Spence SJ, 2009, PEDIATR RES, V65, P599, DOI 10.1203/PDR.0b013e31819e7168 Stankovski L, 2007, J NEUROSCI, V27, P1315, DOI 10.1523/JNEUROSCI.4395-06.2007 Stone KJ, 2003, AM FAM PHYSICIAN, V68, P498 STROMLAND K, 1994, DEV MED CHILD NEUROL, V36, P351 SUNDSTROM E, 1993, DEV BRAIN RES, V75, P1, DOI 10.1016/0165-3806(93)90059-J Suri R, 2007, AM J PSYCHIAT, V164, P1206, DOI 10.1176/appi.ajp.2007.06071172 Suri R, 2004, Arch Womens Ment Health, V7, P193 Suri R, 2011, J CLIN PSYCHIAT, V72, P1002, DOI 10.4088/JCP.10m06135 Szatmari P, 2011, ARCH GEN PSYCHIAT, V68, P1091, DOI 10.1001/archgenpsychiatry.2011.99 TAKAHASHI H, 1986, BRAIN DEV-JPN, V8, P355 Tassone F, 2011, AUTISM RES, V4, P250, DOI 10.1002/aur.196 Tordjman S, 2001, MOL PSYCHIATR, V6, P434, DOI 10.1038/sj.mp.4000873 Udechuku A, 2010, AUST NZ J PSYCHIAT, V44, P978, DOI 10.3109/00048674.2010.507543 US Food and Drug Administration, 2005, FDA PUBL HLTH ADV PA US Food and Drug Administration, 2006, FDA PUBL HLTH ADV TR Vitalis T, 2007, EUR J NEUROSCI, V26, P331, DOI 10.1111/j.1460-9568.2007.05661.x Walther DJ, 2003, SCIENCE, V299, P76, DOI 10.1126/science.1078197 Weikum WM, 2012, P NATL ACAD SCI USA, V109, P17221, DOI 10.1073/pnas.1121263109 WHITAKERAZMITIA PM, 1994, NEUROPSYCHOPHARMACOL, V11, P125 WhitakerAzmitia PM, 1996, BEHAV BRAIN RES, V73, P19 Whitaker-Azmitia PM, 2001, BRAIN RES BULL, V56, P479, DOI 10.1016/S0361-9230(01)00615-3 Whitaker-Azmitia PM, 1998, ANN NY ACAD SCI, V846, P158, DOI 10.1111/j.1749-6632.1998.tb09734.x Whitaker-Azmitia PM, 2005, INT J DEV NEUROSCI, V23, P75, DOI 10.1016/j.ijdevneu.2004.07.022 White Kellie J, 2005, AAPS J, V7, pE421, DOI 10.1208/aapsj070242 Wichman CL, 2009, MAYO CLIN PROC, V84, P23, DOI 10.4065/84.1.23 Williams K., 2010, COCHRANE DATABASE SY Williams PG, 1997, DEV MED CHILD NEUROL, V39, P632 Wilson KL, 2011, AM J PERINAT, V28, P19, DOI 10.1055/s-0030-1262507 Winter C, 2008, EUR NEUROPSYCHOPHARM, V18, P712, DOI 10.1016/j.euroneuro.2008.06.001 Wisner KL, 2009, AM J PSYCHIAT, V166, P557, DOI 10.1176/appi.ajp.2008.08081170 Xu YL, 2004, DEV BRAIN RES, V150, P151, DOI 10.1016/j.devbrainres.2003.02.001 Yonkers KA, 2011, EPIDEMIOLOGY, V22, P848, DOI 10.1097/EDE.0b013e3182306847 Yonkers KA, 2009, OBSTET GYNECOL, V114, P703, DOI [10.1097/AOG.0b013e3181ba0632, 10.1016/j.genhosppsych.2009.04.003] Yoo HJ, 2009, NEUROSCI RES, V63, P172, DOI 10.1016/j.neures.2008.11.007 Zhang XD, 2004, SCIENCE, V305, P217, DOI 10.1126/science.1097540 NR 194 TC 12 Z9 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2013 VL 6 IS 3 BP 149 EP 168 DI 10.1002/aur.1288 PG 20 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 164EI UT WOS:000320391300001 PM 23495208 ER PT J AU Schwichtenberg, AJ Young, GS Hutman, T Iosif, AM Sigman, M Rogers, SJ Ozonoff, S AF Schwichtenberg, Amy Jo Young, Gregory S. Hutman, Ted Iosif, Ana-Maria Sigman, Marian Rogers, Sally J. Ozonoff, Sally TI Behavior and Sleep Problems in Children With a Family History of Autism SO AUTISM RESEARCH LA English DT Article DE autism; siblings; behavior problems; sleep ID SPECTRUM DISORDERS; CHRONIC DISABILITIES; SIBLINGS; RISK; ASSOCIATION; ADJUSTMENT; TEMPERAMENT; PSYCHOPATHOLOGY; COMPETENCE; CHILDHOOD AB The present study explores behavioral and sleep outcomes in preschool-age siblings of children with autism spectrum disorders (ASD). This study focuses on behavior problems that are common in children with ASD, such as emotional reactivity, anxiety, inattention, aggression, and sleep problems. Infant siblings were recruited from families with at least one older child with ASD (high-risk group, n = 104) or families with no history of ASD (low-risk group, n = 76). As part of a longitudinal prospective study, children completed the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule, and parents completed the Child Behavior Checklist (CBCL) and the Social Communication Questionnaire at 36 months of age. This study focuses on developmental concerns outside of ASD; therefore, only siblings who did not develop an ASD were included in analyses. Negative binomial regression analyses revealed that children in the high-risk group were more likely to have elevated behavior problems on the CBCL Anxious/Depressed and Aggression subscales. To explore sleep problems as a correlate of these behavior problems, a second series of models was specified. For both groups of children, sleep problems were associated with elevated behavior problems in each of the areas assessed (reactivity, anxiety, somatic complaints, withdrawal, attention, and aggression). These findings support close monitoring of children with a family history of ASD for both behavioral and sleep issues. Autism Res 2013, 6: 169-176. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Schwichtenberg, Amy Jo; Young, Gregory S.; Rogers, Sally J.; Ozonoff, Sally] Calif State Univ Sacramento, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA. [Hutman, Ted; Sigman, Marian] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Iosif, Ana-Maria] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA. RP Schwichtenberg, AJ (reprint author), Calif State Univ Sacramento, Dept Psychiat & Behav Sci, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA. EM ajschwichtenberg@ucdavis.edu FU National Institute of Mental Health [K99/R00 MH092431, R01 MH068398, U54 MH068172] FX This research was supported by the following grants. Grant sponsor: National Institute of Mental Health; Grant numbers: K99/R00 MH092431 (Schwichtenberg), R01 MH068398 (Ozonoff), and U54 MH068172 (Sigman). CR Achenbach T. M., 2000, CHILD BEHAV CHECKLIS Achenbach TM, 2002, SCHOOL PSYCHOL REV, V31, P428 Aronen R., 2000, J AM ACAD CHILD ADOL, V39, P502 Brian J, 2008, AUTISM, V12, P433, DOI 10.1177/1362361308094500 Chilcoat HD, 1997, J AM ACAD CHILD PSY, V36, P971, DOI 10.1097/00004583-199707000-00020 Constantino JN, 2006, AM J PSYCHIAT, V163, P294, DOI 10.1176/appi.ajp.163.2.294 Dempsey AG, 2012, J AUTISM DEV DISORD, V42, P1393, DOI 10.1007/s10803-011-1368-9 Dixon WE, 2006, INFANT BEHAV DEV, V29, P342, DOI 10.1016/j.infbeh.2006.01.002 Durmer JS, 2005, SEMIN NEUROL, V25, P117, DOI 10.1055/s-2005-867080 Fisman S, 1996, J AM ACAD CHILD PSY, V35, P1532, DOI 10.1097/00004583-199611000-00023 Fisman S, 2000, CAN J PSYCHIAT, V45, P369 Garon N, 2009, J ABNORM CHILD PSYCH, V37, P59, DOI 10.1007/s10802-008-9258-0 Goodlin-Jones B, 2009, J CHILD PSYCHOL PSYC, V50, P1532, DOI 10.1111/j.1469-7610.2009.02110.x Goodnight JA, 2007, J FAM PSYCHOL, V21, P39, DOI 10.1037/0893-3200.21.1.39 Gray K, 2012, AJIDD-AM J INTELLECT, V117, P121, DOI 10.1352/1944-7588-117-2.121 Gregory AM, 2002, J AM ACAD CHILD PSY, V41, DOI 10.1097/00004583-200208000-00015 Hollander E., 2011, TXB AUTISM SPECTRUM Kaminsky L, 2002, J CHILD PSYCHOL PSYC, V43, P225, DOI 10.1111/1469-7610.00015 Konstantareas MM, 2006, J AUTISM DEV DISORD, V36, P143, DOI 10.1007/s10803-005-0051-4 Lavigne JV, 1999, J DEV BEHAV PEDIATR, V20, P164 Lord C., 2002, AUTISM DIAGNOSTIC OB Mindell J, 2003, CLIN GUIDE PEDIAT SL Moricke E, 2010, EUR CHILD ADOLES PSY, V19, P659, DOI 10.1007/s00787-010-0103-y Mullen E, 1995, MULLEN SCALES EARLY Orsmond GI, 2007, MENT RETARD DEV D R, V13, P313, DOI 10.1002/mrdd.20171 Ozonoff S, 2011, PEDIATRICS, V128, pE488, DOI 10.1542/peds.2010-2825 Paavonen EJ, 2009, EUR CHILD ADOLES PSY, V18, P747, DOI 10.1007/s00787-009-0033-8 Reid GJ, 2009, J SLEEP RES, V18, P49, DOI 10.1111/j.1365-2869.2008.00692.x Richdale AL, 2009, SLEEP MED REV, V13, P403, DOI 10.1016/j.smrv.2009.02.003 RODRIGUE JR, 1993, J AUTISM DEV DISORD, V23, P665, DOI 10.1007/BF01046108 Rogers S., 2009, AUTISM RES, V1, P1 Rutter M., 2003, SCQ SOCIAL COMMUNICA Rzepecka H, 2011, RES DEV DISABIL, V32, P2758, DOI 10.1016/j.ridd.2011.05.034 SAS Institute, 2002, SAS STAT VERS 9 2 Scher A, 2001, DEV PSYCHOBIOL, V38, P274, DOI 10.1002/dev.1020 Schwichtenberg AJ, 2010, J CHILD PSYCHOL PSYC, V51, P1021, DOI 10.1111/j.1469-7610.2010.02267.x Shang CY, 2006, J SLEEP RES, V15, P63, DOI 10.1111/j.1365-2869.2006.00492.x Smith T., 2005, J DEV DISABIL, V11, P77 Young Margaret B., 2012, Morbidity and Mortality Weekly Report, V61, P1 Tompson MC, 2010, J ABNORM CHILD PSYCH, V38, P105, DOI 10.1007/s10802-009-9349-6 Verte S, 2003, CHILD CARE HLTH DEV, V29, P193, DOI 10.1046/j.1365-2214.2003.00331.x Yokomaku A, 2008, CHRONOBIOL INT, V25, P549, DOI 10.1080/07420520802261705 Yu JW, 2006, MATERN CHILD HLTH J, V10, P329, DOI 10.1007/s10995-005-0066-7 Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001 NR 44 TC 3 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2013 VL 6 IS 3 BP 169 EP 176 DI 10.1002/aur.1278 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 164EI UT WOS:000320391300002 PM 23436793 ER PT J AU Kourkoulou, A Kuhn, G Findlay, JM Leekam, SR AF Kourkoulou, Anastasia Kuhn, Gustav Findlay, John M. Leekam, Susan R. TI Eye Movement Difficulties in Autism Spectrum Disorder: Implications for Implicit Contextual Learning SO AUTISM RESEARCH LA English DT Article DE autism; eye movements; visual search; implicit learning; contextual cueing ID SUPERIOR VISUAL-SEARCH; ATTENTIONAL GUIDANCE; ASPERGER SYNDROME; SPATIAL CONTEXT; CHILDREN; INFORMATION; INDIVIDUALS; TASK; DISCRIMINATION; RECOGNITION AB It is widely accepted that we use contextual information to guide our gaze when searching for an object. People with autism spectrum disorder (ASD) also utilise contextual information in this way; yet, their visual search in tasks of this kind is much slower compared with people without ASD. The aim of the current study was to explore the reason for this by measuring eye movements. Eye movement analyses revealed that the slowing of visual search was not caused by making a greater number of fixations. Instead, participants in the ASD group were slower to launch their first saccade, and the duration of their fixations was longer. These results indicate that slowed search in ASD in contextual learning tasks is not due to differences in the spatial allocation of attention but due to temporal delays in the initial-reflexive orienting of attention and subsequent-focused attention. These results have broader implications for understanding the unusual attention profile of individuals with ASD and how their attention may be shaped by learning. Autism Res 2013, 6: 177-189. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Kourkoulou, Anastasia; Leekam, Susan R.] Cardiff Univ, Wales Autism Res Ctr, Sch Psychol, Cardiff CF10 3AX, S Glam, Wales. [Kuhn, Gustav] Univ London, Dept Psychol, New Cross, NW, England. [Findlay, John M.] Univ Durham, Dept Psychol, Durham DH1 3LE, England. RP Kourkoulou, A (reprint author), Univ Athens, Dept Psychiat, Sch Med, Aeginit Hosp, 72 V Sofias Ave, Athens 11528, Greece. EM kourkouloua@gmail.com FU Durham University; Cardiff University FX We are grateful to the college staff and students from the European Services for People with Autism assisting with and participating in the study. We also thank the reviewers for their constructive comments and suggestions. AK was supported by a PhD studentship from Durham University and post-doctoral funding from Cardiff University. No conflict of interest to declare. CR Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003 Barnes KA, 2008, NEUROPSYCHOLOGY, V22, P563, DOI 10.1037/0894-4105.22.5.563 Brady TF, 2007, J EXP PSYCHOL HUMAN, V33, P798, DOI 10.1037/0096-1523.33.4.798 Brock J, 2011, PERCEPTION, V40, P739, DOI 10.1068/p6953 Brockmole JR, 2006, Q J EXP PSYCHOL, V59, P1177, DOI 10.1080/17470210600665996 Brown J, 2010, Q J EXP PSYCHOL, V63, P1789, DOI 10.1080/17470210903536910 Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072 Chun MM, 1999, NAT NEUROSCI, V2, P844, DOI 10.1038/12222 Chun MM, 1998, COGNITIVE PSYCHOL, V36, P28, DOI 10.1006/cogp.1998.0681 Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488 de Jonge MV, 2007, NEUROPSYCHOLOGY, V21, P65, DOI 10.1037/0894-4105.21.1.65 Falter CM, 2008, J AUTISM DEV DISORD, V38, P507, DOI 10.1007/s10803-007-0419-8 Findlay J. M., 2004, INTERFACE LANGUAGE V, P135 Findlay JM, 1999, BEHAV BRAIN SCI, V22, P661 Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016 Goldberg MC, 2002, NEUROPSYCHOLOGIA, V40, P2039, DOI 10.1016/S0028-3932(02)00059-3 GREENHOUSE SW, 1959, PSYCHOMETRIKA, V24, P95, DOI 10.1007/BF02289823 HAPPE FGE, 1994, J CHILD PSYCHOL PSYC, V35, P1461, DOI 10.1111/j.1469-7610.1994.tb01287.x Hidalgo-Sotelo B., 2005, P IEEE COMP SOC C CO, V3, P86 Ho TC, 2009, J NEUROSCI, V29, P8675, DOI 10.1523/JNEUROSCI.5984-08.2009 Hooge ITC, 1998, VISION RES, V38, P1295, DOI 10.1016/S0042-6989(97)00287-3 Hout MC, 2012, J EXP PSYCHOL HUMAN, V38, P90, DOI 10.1037/a0023894 Iarocci G, 2006, J AUTISM DEV DISORD, V36, P117, DOI 10.1007/s10803-005-0045-2 Jarrold C, 2005, DEVELOPMENTAL SCI, V8, P344, DOI 10.1111/j.1467-7687.2005.00422.x Jiang Y. V., 2012, J EXPT PSYCHOL HUMAN, DOI 10.1037/a0028022 Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x Kemner C, 2008, J AUTISM DEV DISORD, V38, P553, DOI 10.1007/s10803-007-0406-0 Kikuchi Y, 2011, J AUTISM DEV DISORD, V41, P629, DOI 10.1007/s10803-010-1082-z Kourkoulou A, 2012, J AUTISM DEV DISORD, V42, P244, DOI 10.1007/s10803-011-1237-6 Kuhn G, 2010, PSYCHOL SCI, V21, P1487, DOI 10.1177/0956797610383435 Kunar MA, 2008, VIS COGN, V16, P804, DOI 10.1080/13506280701751224 Kunar MA, 2007, J EXP PSYCHOL HUMAN, V33, P816, DOI 10.1037/0096-1523.33.4.816 Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x Liversedge SP, 2000, TRENDS COGN SCI, V4, P6, DOI 10.1016/S1364-6613(99)01418-7 Lopez B, 2004, VIS COGN, V11, P673, DOI 10.1080/13506280344000437 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Ludwig CJH, 2005, J NEUROSCI, V25, P9907, DOI 10.1523/JNEURSCI.2197-05.2005 Mauchly JW, 1940, ANN MATH STAT, V11, P204, DOI 10.1214/aoms/1177731915 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Navalpakkam V, 2006, J VISION, V6, P1180, DOI 10.1167/6.11.4 Neider MB, 2006, VISION RES, V46, P614, DOI 10.1016/j.visres.2005.08.025 Oliva A, 2007, TRENDS COGN SCI, V11, P520, DOI 10.1016/j.tics.2007.09.009 Olson IR, 2002, VIS COGN, V9, P273, DOI 10.1080/13506280042000162 O'Riordan M, 2001, Q J EXP PSYCHOL-A, V54, P961, DOI 10.1080/02724980042000543 O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719 O'Riordan MA, 2004, AUTISM, V8, P229, DOI 10.1177/1362361304045219 Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003 Pellicano E, 2012, TRENDS COGN SCI, V16, P504, DOI 10.1016/j.tics.2012.08.009 Pellicano E., 2010, P NATL ACAD SCI USA, V108, P421 Peterson RS, 2001, PERCEPT PSYCHOPHYS, V63, P1239 Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613 Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489 Ropar D, 2001, J CHILD PSYCHOL PSYC, V42, P539, DOI 10.1111/1469-7610.00748 Samson F, 2012, HUM BRAIN MAPP, V33, P1553, DOI 10.1002/hbm.21307 SCHNEIDER W, 1977, PSYCHOL REV, V84, P1, DOI 10.1037/0033-295X.84.1.1 Senju A, 2009, SCIENCE, V325, P883, DOI 10.1126/science.1176170 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005 Soulieres I., 2010, Q J EXPT PSYCHOL, V64, P311 Sweeney JA, 2004, CURR OPIN NEUROL, V17, P37, DOI 10.1097/01.wco.0000113936.12823.ad Tseng YC, 2004, PERCEPT PSYCHOPHYS, V66, P1363, DOI 10.3758/BF03195004 van Asselen M, 2011, ATTEN PERCEPT PSYCHO, V73, P297, DOI 10.3758/s13414-010-0047-9 Wechsler D, 1999, WECHSLER ABBREVIATED WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288 NR 69 TC 3 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2013 VL 6 IS 3 BP 177 EP 189 DI 10.1002/aur.1274 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 164EI UT WOS:000320391300003 PM 23436788 ER PT J AU Coskun, MA Loveland, KA Pearson, DA Papanicolaou, AC Sheth, BR AF Coskun, Mehmet Akif Loveland, Katherine A. Pearson, Deborah A. Papanicolaou, Andrew C. Sheth, Bhavin R. TI Functional Assays of Local Connectivity in the Somatosensory Cortex of Individuals with Autism SO AUTISM RESEARCH LA English DT Article DE connectivity; somatotopy; cortical inhibition; local excitation; tactile; homeostasis; touch; MEG ID MOUSE MODEL; SENTENCE COMPREHENSION; SPECTRUM DISORDERS; BRAIN CONNECTIVITY; RETT-SYNDROME; RESPONSES; UNDERCONNECTIVITY; SYNCHRONIZATION; INHIBITION; EXCITATION AB Emerging evidence for differences between individuals with autism spectrum disorder (ASD) and neurotypical (NT) individuals in somatic processing and brain response to touch suggests somatosensory cortex as a promising substrate for elucidating differences in functional brain connectivity between individuals with and without autism. Signals from adjacent digits project to neighboring locations or representations in somatosensory cortex. When a digit is stimulated, i.e. touched, its representation in cortex is directly activated; local intracortical connections indirectly activate nonprimary cortical representations corresponding to adjacent digits. The response of the nonprimary cortical representations is thus a proxy for connection strength. Local overconnectivity in autism implies that the nonprimary/primary response ratios of the ASD group will be higher than those of the NT group. D1 and D2 of the dominant hand of the participant were individually stimulated while we recorded neural responses using magnetoencephalography. The cortical representations of D1 and D2 (somatosensory-evoked fields) were computed from the ensemble-averaged data using (a) dipole model fits and (b) singular value decomposition. Individual adjacent/primary response ratios were measured, and group response ratio data were fitted with straight lines. Local overconnectivity in autism implies steeper ASD vs. NT group slopes. Our findings did not support local overconnectivity. Slopes were found to be significantly shallower for the ASD group than the NT group. Our findings support the idea of local underconnectivity in the somatosensory cortex of the brains of individuals with ASD. Autism Res 2013, 6: 190-200. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Coskun, Mehmet Akif; Sheth, Bhavin R.] Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA. [Loveland, Katherine A.; Pearson, Deborah A.] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA. [Papanicolaou, Andrew C.] Univ Texas Hlth Sci Ctr Houston, Dept Pediat, Houston, TX 77030 USA. [Sheth, Bhavin R.] Univ Houston, Ctr NeuroEngn & Cognit Syst, Houston, TX 77204 USA. RP Sheth, BR (reprint author), Univ Houston, Houston, TX 77204 USA. EM brsheth@uh.edu FU National Alliance for Autism Research-Autism Speaks; University of Houston; National Institutes of Health [P01 HD035471, R01 MH072263] FX The authors report no competing interests. The research was supported by a grant from the National Alliance for Autism Research-Autism Speaks (BRS). MAC was supported in part by a Presidential fellowship from the University of Houston. KAL and DAP were supported by the National Institutes of Health: P01 HD035471 (KAL) and R01 MH072263 (DAP). CR Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190 Baranek G. T., 2005, HDB AUTISM PERVASIVE, VII, P831 Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6 BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 Barttfeld P, 2011, NEUROPSYCHOLOGIA, V49, P254, DOI 10.1016/j.neuropsychologia.2010.11.024 Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004 Braeutigam S, 2008, EUR J NEUROSCI, V27, P1026, DOI 10.1111/j.1460-9568.2008.06064.x Cardin JA, 2009, NATURE, V459, P663, DOI 10.1038/nature08002 Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5 Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189 Chubykin AA, 2007, NEURON, V54, P919, DOI 10.1016/j.neuron.2007.05.029 Coskun MA, 2009, NEUROREPORT, V20, P1543, DOI 10.1097/WNR.0b013e32833246b5 Coskun MA, 2009, NEUROREPORT, V20, P175, DOI 10.1097/WNR.0b013e32831f47d1 Dani VS, 2009, J NEUROSCI, V29, P11263, DOI 10.1523/JNEUROSCI.1019-09.2009 Dani VS, 2005, P NATL ACAD SCI USA, V102, P12560, DOI 10.1073/pnas.0506071102 Dinstein I, 2012, NEURON, V75, P981, DOI 10.1016/j.neuron.2012.07.026 Duffy FH, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-64 Gardner EP, 2000, PRINCIPLES NEURAL SC, P451 Gibson JR, 2008, J NEUROPHYSIOL, V100, P2615, DOI 10.1152/jn.90752.2008 Goldreich D, 1999, J NEUROPHYSIOL, V82, P1311 Grandin T., 1995, THINKING PICTURES OT Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 HILLYARD SA, 1971, SCIENCE, V172, P1357, DOI 10.1126/science.172.3990.1357 HORWITZ B, 1988, ARCH NEUROL-CHICAGO, V45, P749 Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Keita L, 2010, AUTISM RES, V3, P333, DOI 10.1002/aur.164 Lord C., 1999, AUTISM DIAGNOSTIC OB Milne E., 2011, FRONT PSYCHOL, V2, P1, DOI 10. 3389/fpsyg. 2011. 00051 Miyazaki M, 2007, DEV MED CHILD NEUROL, V49, P13, DOI 10.1017/S0012162207000059 OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4 OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x Picton TW, 1988, HDB ELECTROENCEPHALO, V3, P361 Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7 Rutter M., 2003, AUTISM DIAGNOSTIC IN Tommerdahl M, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-19 Traub RD, 1997, J COMPUT NEUROSCI, V4, P141, DOI 10.1023/A:1008839312043 van Ede F, 2010, NEUROIMAGE, V51, P867, DOI 10.1016/j.neuroimage.2010.02.053 Vissers ME, 2012, NEUROSCI BIOBEHAV R, V36, P604, DOI 10.1016/j.neubiorev.2011.09.003 Wechsler D, 1999, WECHSLER ABBREVIATED Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002 NR 42 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2013 VL 6 IS 3 BP 190 EP 200 DI 10.1002/aur.1276 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 164EI UT WOS:000320391300004 PM 23427110 ER PT J AU Totsika, V Hastings, RP Emerson, E Lancaster, GA Berridge, DM Vagenas, D AF Totsika, Vasiliki Hastings, Richard P. Emerson, Eric Lancaster, Gillian A. Berridge, Damon M. Vagenas, Dimitrios TI Is There a Bidirectional Relationship Between Maternal Well-Being and Child Behavior Problems in Autism Spectrum Disorders? Longitudinal Analysis of a Population-Defined Sample of Young Children SO AUTISM RESEARCH LA English DT Article DE autism; behavior problems; maternal well-being; bidirectional; longitudinal; population-representative ID MENTAL-HEALTH; DIFFICULTIES QUESTIONNAIRE; INTELLECTUAL DISABILITY; GENERAL-POPULATION; EMOTIONAL-PROBLEMS; COGNITIVE DELAY; MISSING DATA; ADOLESCENTS; ASSOCIATIONS; STRENGTHS AB The aim of this study was to examine whether the relationship between maternal psychological well-being and behavior problems in children with an autism spectrum disorder (ASD) is bidirectional. Data were available at 9 months, 3 years, and 5 years old for 132 children with ASD, identified from a population-representative sample of UK children. Three-wave cross-lagged models examined reciprocal effects between child behavior and maternal well-being (psychological distress, physical health functioning, and life satisfaction). Results indicated that the relationships between maternal well-being and child problem behaviors were not bidirectional. Specifically, findings suggested that while early behavior problems are not a risk factor for later maternal well-being, maternal psychological distress, physical health limitations, and lower life satisfaction are risk factors for later child behavior problems. Autism Res 2013, 6: 201-211. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Totsika, Vasiliki; Hastings, Richard P.] Bangor Univ, Sch Psychol, Bangor LL57 2DG, Gwynedd, Wales. [Emerson, Eric] Univ Lancaster, Ctr Disabil Res, Lancaster, England. [Emerson, Eric] Univ Sydney, Sydney, NSW 2006, Australia. [Lancaster, Gillian A.; Berridge, Damon M.] Univ Lancaster, Dept Math & Stat, Lancaster, England. [Vagenas, Dimitrios] Queensland Univ Technol, Inst Hlth Biomed Innovat, Brisbane, Qld 4001, Australia. RP Totsika, V (reprint author), Bangor Univ, Sch Psychol, North Wales Clin Psychol Programme, 43 Coll Rd, Bangor LL57 2DG, Gwynedd, Wales. EM v.totsika@bangor.ac.uk RI Hastings, Richard/D-9657-2013 OI Hastings, Richard/0000-0002-0495-8270 FU Economic and Social Research Council (ESRC) [ESRC RES-000-22-3216] FX Grant Sponsor: Economic and Social Research Council (ESRC), Grant Number: ESRC RES-000-22-3216. CR Allison PD, 2003, J ABNORM PSYCHOL, V112, P545, DOI 10.1037/0021-843X.112.4.545 Arbuckle JL, 2009, AMOS 18 USERS GUIDE Baker JK, 2011, J FAM PSYCHOL, V25, P601, DOI 10.1037/a0024409 Barker ET, 2011, DEV PSYCHOL, V47, P551, DOI 10.1037/a0021268 Blacher J, 2006, J INTELL DISABIL RES, V50, P184, DOI 10.1111/j.1365-2788.2005.00768.x Blackledge JT, 2006, CHILD FAM BEHAV THER, V28, P1, DOI 10.1300/J019v28n01_01 Byrne B. M., 2010, STRUCTURAL EQUATION, V2nd CAREY WB, 1978, PEDIATRICS, V61, P735 Civic D, 2000, Matern Child Health J, V4, P215, DOI 10.1023/A:1026667720478 Davis NO, 2008, J AUTISM DEV DISORD, V38, P1278, DOI 10.1007/s10803-007-0512-z Department for Environment Food and Rural Affairs (DEFRA), 2011, LIF SAT OTH MEAS WEL DeSalvo KB, 2006, QUAL LIFE RES, V15, P191, DOI 10.1007/s11136-005-0887-2 Elgar FJ, 2003, J CLIN CHILD ADOLESC, V32, P362, DOI 10.1207/S15374424JCCP3203_05 Elliot C. D., 1996, BRIT ABILITY SCALES Emerson E, 2005, J INTELLECT DEV DIS, V30, P14, DOI 10.1080/13668250500033169 Emerson E, 2007, BRIT J PSYCHIAT, V191, P493, DOI 10.1192/bjp.bp.107.038729 Emerson E, 2011, J CHILD PSYCHOL PSYC, V52, P1184, DOI 10.1111/j.1469-7610.2011.02413.x Emerson E, 2010, AJIDD-AM J INTELLECT, V115, P30, DOI 10.1352/1944-7558-115.1.30 Ferraioli S. J., 2012, MINDFULNESS IN PRESS, DOI 10.1007/s12671-012-0099-0 Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015 Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x Gray K, 2012, AJIDD-AM J INTELLECT, V117, P121, DOI 10.1352/1944-7588-117-2.121 Gray KM, 2011, RES DEV DISABIL, V32, P1194, DOI 10.1016/j.ridd.2010.12.044 Greenberg JS, 2006, AM J MENT RETARD, V111, P229, DOI 10.1352/0895-8017(2006)111[229:BEOEEA]2.0.CO;2 Gross HE, 2008, J ABNORM CHILD PSYCH, V36, P693, DOI 10.1007/s10802-008-9224-x HAMMEN C, 1990, DEV PSYCHOL, V26, P24, DOI 10.1037/0012-1649.26.1.24 Hastings RP, 2005, J AUTISM DEV DISORD, V35, P635, DOI 10.1007/s10803-005-0007-8 Iizuka C, 2010, BRAIN DEV-JPN, V32, P609, DOI 10.1016/j.braindev.2009.09.009 Kanner L, 1943, NERV CHILD, V2, P217 Kessler RC, 2002, PSYCHOL MED, V32, P959, DOI 10.1017/S0033291702006074 Kessler RC, 2003, ARCH GEN PSYCHIAT, V60, P184, DOI 10.1001/archpsyc.60.2.184 Kraemer HC, 2010, INT J ENV RES PUB HE, V7, P29, DOI 10.3390/ijerph7010029 Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x Lounds J, 2007, AM J MENT RETARD, V112, P401, DOI 10.1352/0895-8017(2007)112[401:TACIAA]2.0.CO;2 Mandell DS, 2005, PEDIATRICS, V116, P1480, DOI 10.1542/peds.2005-0185 Maruish ME, 2009, GUIDE DEV CERTIFIED McIntyre LL, 2008, J INTELL DISABIL RES, V52, P1176, DOI 10.1111/j.1365-2788.2008.01108.x National Evaluation of Sure Start (NESS) Research Team, 2005, EARL IMP SUR START L Nicholson JS, 2011, DEV PSYCHOL, V47, P1312, DOI 10.1037/a0023912 Plewis I., 2007, MILLENNIUM COHORT ST, V4th Rodgers B, 1999, SOC PSYCH PSYCH EPID, V34, P333, DOI 10.1007/s001270050153 Rutter M., 1970, ED HLTH BEHAV Sameroff A., 2009, T MODEL DEV CHILDREN, P3, DOI [10.1037/11877-001, DOI 10.1037/11877-001] Sameroff A, 2010, CHILD DEV, V81, P6, DOI 10.1111/j.1467-8624.2009.01378.x Sameroff AJ, 2003, DEV PSYCHOPATHOL, V15, P613, DOI 10.1017/S0954579403000312 Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147 Schimmack U, 2005, J PERS SOC PSYCHOL, V89, P395, DOI 10.1037/0022-3514.89.3.395 Shaw D. S., 2009, T MODEL DEV CHILDREN, P77, DOI DOI 10.1037/11877-005 Singh NN, 2006, J EMOT BEHAV DISORD, V14, P169, DOI 10.1177/10634266060140030401 Sofronoff K, 2011, RES DEV DISABIL, V32, P2253, DOI 10.1016/j.ridd.2011.07.046 Totsika V, 2011, J CHILD PSYCHOL PSYC, V52, P91, DOI 10.1111/j.1469-7610.2010.02295.x Totsika V, 2011, J ABNORM CHILD PSYCH, V39, P1137, DOI 10.1007/s10802-011-9534-2 Ware J, 2001, SCORE INTERPRET SING NR 53 TC 5 Z9 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2013 VL 6 IS 3 BP 201 EP 211 DI 10.1002/aur.1279 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 164EI UT WOS:000320391300005 PM 23436803 ER PT J AU Shah, CR Forsberg, CG Kang, JQ Veenstra-VanderWeele, J AF Shah, Charisma R. Forsberg, Carl Gunnar Kang, Jing-Qiong Veenstra-VanderWeele, Jeremy TI Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical SO AUTISM RESEARCH LA English DT Article DE animal models; behavioral analysis of animal models < animal models; genetics; gamma-aminobutyric acid < neurochemistry ID AUTISM SPECTRUM DISORDERS; NEONATAL RISK-FACTORS; LINKAGE-DISEQUILIBRIUM; INBRED STRAINS; COMPREHENSIVE METAANALYSIS; CHROMOSOME 15Q11-Q13; APPROACH BEHAVIORS; GABA(A) RECEPTOR; FOOD PREFERENCE; MODEL SYSTEM AB Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a "typical" way. We hypothesized that mice could be used to make a similar judgment if they prefer "typical" over "atypical" social interactions with mouse models relevant to ASD. We used wild-type C57BL/6 (B6) mice as "judges" and evaluated their preference for a chamber containing a "typical" (B6 or 129S6) or an "atypical" mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/-). Overall, we observed a stimulus by time interaction (P < 0.0001), with B6 mice preferring the typical mouse chamber during the last 10 min of the 30-min test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P = 0.0007; Gabrb3 +/- vs. 129S6, P = 0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P = 0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P = 0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P = 0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. Autism Res 2013, 6: 212-220. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Shah, Charisma R.; Forsberg, Carl Gunnar; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37235 USA. [Kang, Jing-Qiong] Vanderbilt Univ, Dept Neurol, Nashville, TN 37235 USA. [Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Pediat,Vanderbilt Brain Inst, Treatment & Res Inst Autism Spectrum Disorder, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN USA. [Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Pharmacol,Vanderbilt Brain Inst, Treatment & Res Inst Autism Spectrum Disorder, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN USA. RP Veenstra-VanderWeele, J (reprint author), 7158 Med Res Bldg 3,465 21st Ave S, Nashville, TN 37232 USA. EM j.vvw@vanderbilt.edu FU NIMH [MH81066] FX Grant sponsor: NIMH; Grant number MH81066. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Beglinger L, 2005, J AUTISM DEV DISORD, V35, P295, DOI 10.1007/s10803-005-3292-3 Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078 Bolivar VJ, 2007, BEHAV BRAIN RES, V176, P21, DOI 10.1016/j.bbr.2006.09.007 Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011 Carter MD, 2011, AUTISM RES, V4, P57, DOI 10.1002/aur.180 CASTELLOE P, 1993, J AUTISM DEV DISORD, V23, P229, DOI 10.1007/BF01046217 Chadman KK, 2011, PHARMACOL BIOCHEM BE, V97, P586, DOI 10.1016/j.pbb.2010.09.012 Cook EH, 1998, AM J HUM GENET, V62, P1077, DOI 10.1086/301832 Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x Curran S, 2005, AM J MED GENET B, V137B, P25, DOI 10.1002/ajmg.b.30126 DELAHANTY RJ, 2010, MOL PSYCHIATR, V16, P86 DeLorey TM, 1998, J NEUROSCI, V18, P8505 DeLorey TM, 2008, BEHAV BRAIN RES, V187, P207, DOI 10.1016/j.bbr.2007.09.009 Devlin B, 2012, CURR OPIN GENET DEV, V22, P229, DOI 10.1016/j.gde.2012.03.002 Ey E, 2011, AUTISM RES, V4, P5, DOI 10.1002/aur.175 Fairless AH, 2011, ANAT REC, V294, P1713, DOI 10.1002/ar.21318 Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672 Gardener H, 2011, PEDIATRICS, V128, P344, DOI 10.1542/peds.2010-1036 Gould GG, 2011, J NEUROCHEM, V116, P291, DOI 10.1111/j.1471-4159.2010.07104.x Guinchat V, 2012, ACTA OBSTET GYN SCAN, V91, P287, DOI 10.1111/j.1600-0412.2011.01325.x Homanics GE, 1997, P NATL ACAD SCI USA, V94, P4143, DOI 10.1073/pnas.94.8.4143 Jacome LF, 2011, AUTISM RES, V4, P393, DOI 10.1002/aur.218 Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Maestrini E, 1999, AM J MED GENET, V88, P492, DOI 10.1002/(SICI)1096-8628(19991015)88:5<492::AID-AJMG11>3.0.CO;2-X Martin ER, 2000, AM J MED GENET, V96, P43, DOI 10.1002/(SICI)1096-8628(20000207)96:1<43::AID-AJMG9>3.0.CO;2-3 McCauley JL, 2004, AM J MED GENET B, V131B, P51, DOI 10.1002/ajmg.b.30038 McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030 Moy SS, 2008, MOL PSYCHIATR, V13, P4, DOI 10.1038/sj.mp.4002082 Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x Nurmi EL, 2003, J AM ACAD CHILD PSY, V42, P856, DOI 10.1097/01.CHI.0000046868.56865.0F OBrien SK, 1996, J AUTISM DEV DISORD, V26, P321, DOI 10.1007/BF02172477 Panksepp JB, 2007, GENES BRAIN BEHAV, V6, P661, DOI 10.1111/j.1601-183X.2006.00295.x Peca J, 2011, NATURE, V472, P437, DOI 10.1038/nature09965 Pobbe RLH, 2010, BEHAV BRAIN RES, V214, P443, DOI 10.1016/j.bbr.2010.06.025 Roullet FI, 2010, BEHAV BRAIN RES, V216, P19, DOI [10.1016/j.bbr.2010.06.004, DOI 10.1016/J.BBR.2010.06.004] Ryan BC, 2008, BEHAV BRAIN RES, V193, P235, DOI 10.1016/j.bbr.2008.06.002 Salmon B, 1999, AM J MED GENET, V88, P551, DOI 10.1002/(SICI)1096-8628(19991015)88:5<551::AID-AJMG21>3.0.CO;2-# Sankoorikal GMV, 2006, BIOL PSYCHIAT, V59, P415, DOI 10.1016/j.biopsych.2005.07.026 Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846 Silverman J. L., 2012, SCI TRANSL MED, V4 SILVERMAN JL, 2012, NEUROPHARMACOLOGY, V64, P268 Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851 Spencer CM, 2005, GENES BRAIN BEHAV, V4, P420, DOI 10.1111/j.1601-183X.00123.x State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924 Veenstra-VanderWeele J, 2012, NEUROPSYCHOPHARMACOL, V37, P196, DOI 10.1038/npp.2011.185 Veenstra-VanderWeele J, 2012, P NATL ACAD SCI USA, V109, P5469, DOI 10.1073/pnas.1112345109 Volkmar FR, 2009, J CHILD PSYCHOL PSYC, V50, P108, DOI 10.1111/j.1469-7610.2008.02010.x WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288 Winslow JT, 2003, CURRENT PROTOCOLS NE WINSLOW JT, 1983, PSYCHOPHARMACOLOGY, V81, P286, DOI 10.1007/BF00427564 Wrenn CC, 2003, BEHAV NEUROSCI, V117, P21, DOI 10.1037/0735-7044.117.1.21 Yang M, 2012, J NEUROSCI, V32, P6525, DOI 10.1523/JNEUROSCI.6107-11.2012 Yang M, 2009, EUR J NEUROSCI, V29, P1663, DOI 10.1111/j.1460-9568.2009.06714.x YANG M, 2011, CURRENT PROTOCOLS NE, P26 Yang M, 2011, AUTISM RES, V4, P17, DOI 10.1002/aur.163 Yang M, 2012, PHYSIOL BEHAV, V107, P649, DOI 10.1016/j.physbeh.2011.12.025 Zwaigenbaum L, 2009, PEDIATRICS, V123, P1383, DOI 10.1542/peds.2008-1606 NR 62 TC 2 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2013 VL 6 IS 3 BP 212 EP 220 DI 10.1002/aur.1280 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 164EI UT WOS:000320391300006 PM 23436806 ER PT J AU John, A Tatard-Leitman, VM Suh, J Billingslea, EN Roberts, TP Siegel, SJ AF Saunders, John A. Tatard-Leitman, Valerie M. Suh, Jimmy Billingslea, Eddie N. Roberts, Timothy P. Siegel, Steven J. TI Knockout of NMDA Receptors in Parvalbumin Interneurons Recreates Autism-Like Phenotypes SO AUTISM RESEARCH LA English DT Article DE autism; electrophysiology; endophenotype; animal models; NMDA receptor 1 knockout ID MICE MUS-MUSCULUS; MOUSE MODELS; NEURODEVELOPMENTAL DISORDERS; ULTRASONIC VOCALIZATIONS; NEURAL SYNCHRONIZATION; SCHIZOPHRENIA; OSCILLATIONS; DEFICITS; IMPAIRMENT; POTENTIALS AB Autism is a disabling neurodevelopmental disorder characterized by social deficits, language impairment, and repetitive behaviors with few effective treatments. New evidence suggests that autism has reliable electrophysiological endophenotypes and that these measures may be caused by n-methyl-d-aspartic acid receptor (NMDAR) disruption on parvalbumin (PV)-containing interneurons. These findings could be used to create new translational biomarkers. Recent developments have allowed for cell-type selective knockout of NMDARs in order to examine the perturbations caused by disrupting specific circuits. This study examines several electrophysiological and behavioral measures disrupted in autism using a PV-selective reduction in NMDA R1 subunit. Mouse electroencephalograph (EEG) was recorded in response to auditory stimuli. Event-related potential (ERP) component amplitude and latency analysis, social testing, and premating ultrasonic vocalizations (USVs) recordings were performed. Correlations were examined between the ERP latency and behavioral measures. The N1 ERP latency was delayed, sociability was reduced, and mating USVs were impaired in PV-selective NMDA Receptor 1 Knockout (NR1 KO) as compared with wild-type mice. There was a significant correlation between N1 latency and sociability but not between N1 latency and premating USV power or T-maze performance. The increases in N1 latency, impaired sociability, and reduced vocalizations in PV-selective NR1 KO mice mimic similar changes found in autism. Electrophysiological changes correlate to reduced sociability, indicating that the local circuit mechanisms controlling N1 latency may be utilized in social function. Therefore, we propose that behavioral and electrophysiological alterations in PV-selective NR1 KO mice may serve as a useful model for therapeutic development in autism. Autism Res 2013, 6: 6977. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Saunders, John A.; Tatard-Leitman, Valerie M.; Suh, Jimmy; Billingslea, Eddie N.; Siegel, Steven J.] Univ Penn, Dept Psychiat, Translat Neurosci Program, Philadelphia, PA 19104 USA. [Saunders, John A.; Roberts, Timothy P.; Siegel, Steven J.] Univ Penn, Bioengn Grad Grp, Philadelphia, PA 19104 USA. [Roberts, Timothy P.] Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA. RP Siegel, SJ (reprint author), Univ Penn, Dept Psychiat, Translat Res Labs, 125 S 31st St, Philadelphia, PA 19104 USA. EM siegels@upenn.edu FU NIMH [5R01DA023210-02]; Oberkircher Family; Eli Lilly; AstraZeneca; NuPathe; Pfizer; Merck; Sanofi; Wyeth FX Grant sponsor: NIMH; Grant number: 5R01DA023210-02 (SJS).Grant sponsor: Oberkircher Family; Grant number: Oberkircher Family Endowed Chair in Pediatric Radiology (TPR).The study was supported by 5R01DA023210-02 (SJS). Dr. Roberts thanks the Oberkircher Family for the Oberkircher Family Endowed Chair in Pediatric Radiology. Steven Siegel reports having received grant support from Eli Lilly, AstraZeneca, NuPathe, and Pfizer that is unrelated to the content of this paper and consulting payments from NuPathe, Merck, Sanofi, and Wyeth that are unrelated to this work. Dr. Roberts is a consultant for prism clinical imaging. All other authors report no biomedical financial interests or potential conflicts of interest. CR Amann LC, 2010, BRAIN RES BULL, V83, P147, DOI 10.1016/j.brainresbull.2010.04.008 Bangash MA, 2011, CELL, V145, P758, DOI 10.1016/j.cell.2011.03.052 Belforte JE, 2010, NAT NEUROSCI, V13, P76, DOI 10.1038/nn.2447 Cardy JEO, 2008, INT J PSYCHOPHYSIOL, V68, P170, DOI 10.1016/j.ijpsycho.2007.10.015 Carlen M, 2012, MOL PSYCHIATR, V17, P537, DOI 10.1038/mp.2011.31 Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370 Deacon RMJ, 2006, NAT PROTOC, V1, P7, DOI 10.1038/nprot.2006.2 Dinstein I, 2011, NEURON, V70, P1218, DOI 10.1016/j.neuron.2011.04.018 Edgar JC, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P665 Ehrlichman RS, 2009, BRAIN RES, V1294, P116, DOI 10.1016/j.brainres.2009.07.065 Ehrlichman RS, 2009, NEUROSCIENCE, V158, P705, DOI 10.1016/j.neuroscience.2008.10.031 Gandal MJ, 2008, NEUROSCIENCE, V157, P95, DOI 10.1016/j.neuroscience.2008.08.060 Gandal MJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041215 Gandal MJ, 2010, BIOL PSYCHIAT, V68, P1100, DOI 10.1016/j.biopsych.2010.09.031 Gogolla N, 2009, J NEURODEV DISORD, V1, P172, DOI 10.1007/s11689-009-9023-x Gonzalez-Burgos G., 2012, SCHIZOPHRENIA B Gourbal BEF, 2004, NATURWISSENSCHAFTEN, V91, P381, DOI 10.1007/s00114-004-0543-7 Halene TB, 2009, GENES BRAIN BEHAV, V8, P661, DOI 10.1111/j.1601-183X.2009.00504.x Hanlon FM, 2005, PSYCHOPHYSIOLOGY, V42, P417, DOI 10.1111/j.1469-8986.2005.00299.x Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105 Javitt DC, 2000, CLIN NEUROPHYSIOL, V111, P833, DOI 10.1016/S1388-2457(99)00313-2 Lawrence YA, 2010, ACTA NEUROL SCAND, V121, P99, DOI 10.1111/j.1600-0404.2009.01234.x MAGGIO JC, 1985, J COMP PSYCHOL, V99, P420, DOI 10.1037//0735-7036.99.4.420 Mazhari S, 2011, PSYCHIAT RES, V187, P317, DOI 10.1016/j.psychres.2011.01.003 Ricceri L, 2007, BEHAV BRAIN RES, V176, P40, DOI 10.1016/j.bbr.2006.08.024 Roberts TPL, 2011, BIOL PSYCHIAT, V70, P263, DOI 10.1016/j.biopsych.2011.01.015 Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111 Rojas DC, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-66 Rojas DC, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-11 Scattoni ML, 2009, NEUROSCI BIOBEHAV R, V33, P508, DOI 10.1016/j.neubiorev.2008.08.003 Siegel S, 2003, NEUROPSYCHOPHARMACOL, V28, P675, DOI 10.1038/sj.npp.1300087 Sohal VS, 2009, NATURE, V459, P698, DOI 10.1038/nature07991 Umbricht D, 2004, BRAIN RES, V1019, P189, DOI 10.1016/j.brainres.2004.05.097 White NR, 1998, PHYSIOL BEHAV, V63, P467, DOI 10.1016/S0031-9384(97)00484-8 NR 34 TC 0 Z9 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2013 VL 6 IS 2 BP 69 EP 77 DI 10.1002/aur.1264 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 133DL UT WOS:000318117500001 ER PT J AU Prigge, MD Bigler, ED Fletcher, PT Zielinski, BA Ravichandran, C Anderson, J Froehlich, A Abildskov, T Papadopolous, E Maasberg, K Nielsen, JA Alexander, AL Lange, N Lainhart, J AF Prigge, Molly D. Bigler, Erin D. Fletcher, P. Thomas Zielinski, Brandon A. Ravichandran, Caitlin Anderson, Jeffrey Froehlich, Alyson Abildskov, Tracy Papadopolous, Evangelia Maasberg, Kathryn Nielsen, Jared A. Alexander, Andrew L. Lange, Nicholas Lainhart, Janet TI Longitudinal Heschl's Gyrus Growth During Childhood and Adolescence in Typical Development and Autism SO AUTISM RESEARCH LA English DT Article DE autism; Heschl's gyrus; longitudinal development; MRI ID PRIMARY AUDITORY-CORTEX; HUMAN CEREBRAL-CORTEX; NON-SPEECH SOUNDS; SPECTRUM DISORDERS; LANGUAGE IMPAIRMENT; VOLUME MEASUREMENT; PLANUM TEMPORALE; MISMATCH FIELD; CHILDREN; BRAIN AB Heightened auditory sensitivity and atypical auditory processing are common in autism. Functional studies suggest abnormal neural response and hemispheric activation to auditory stimuli, yet the neurodevelopment underlying atypical auditory function in autism is unknown. In this study, we model longitudinal volumetric growth of Heschl's gyrus gray matter and white matter during childhood and adolescence in 40 individuals with autism and 17 typically developing participants. Up to three time points of magnetic resonance imaging data, collected on average every 2.5 years, were examined from individuals 312 years of age at the time of their first scan. Consistent with previous cross-sectional studies, no group differences were found in Heschl's gyrus gray matter volume or asymmetry. However, reduced longitudinal gray matter volumetric growth was found in the right Heschl's gyrus in autism. Reduced longitudinal white matter growth in the left hemisphere was found in the right-handed autism participants. Atypical Heschl's gyrus white matter volumetric growth was found bilaterally in the autism individuals with a history of delayed onset of spoken language. Heightened auditory sensitivity, obtained from the Sensory Profile, was associated with reduced volumetric gray matter growth in the right hemisphere. Our longitudinal analyses revealed dynamic gray and white matter changes in Heschl's gyrus throughout childhood and adolescence in both typical development and autism. Autism Res 2013, 6: 7890. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Prigge, Molly D.; Froehlich, Alyson; Nielsen, Jared A.] Univ Utah, Dept Psychiat, Sch Med, Salt Lake City, UT 84108 USA. [Bigler, Erin D.; Fletcher, P. Thomas; Anderson, Jeffrey] Univ Utah, Inst Brain, Salt Lake City, UT 84108 USA. [Bigler, Erin D.; Abildskov, Tracy] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA. [Bigler, Erin D.; Abildskov, Tracy] Brigham Young Univ, Ctr Neurosci, Provo, UT 84602 USA. [Fletcher, P. Thomas] Univ Utah, Sch Comp, Salt Lake City, UT 84108 USA. [Fletcher, P. Thomas] Univ Utah, Sci Comp & Imaging Inst, Salt Lake City, UT 84108 USA. [Zielinski, Brandon A.] Univ Utah, Dept Pediat, Salt Lake City, UT 84108 USA. [Zielinski, Brandon A.] Univ Utah, Dept Neurol, Salt Lake City, UT 84108 USA. [Ravichandran, Caitlin; Lange, Nicholas] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Anderson, Jeffrey; Nielsen, Jared A.] Univ Utah, Interdept Program Neurosci, Salt Lake City, UT 84108 USA. [Anderson, Jeffrey] Univ Utah, Dept Neuroradiol, Salt Lake City, UT 84108 USA. [Anderson, Jeffrey] Univ Utah, Dept Bioengn, Salt Lake City, UT 84108 USA. [Papadopolous, Evangelia] Univ Utah, Dept Phys, Salt Lake City, UT 84108 USA. [Maasberg, Kathryn] Univ Utah, Sch Med, Salt Lake City, UT 84108 USA. [Alexander, Andrew L.; Lainhart, Janet] Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI USA. [Alexander, Andrew L.] Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA. [Alexander, Andrew L.] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA. [Lange, Nicholas] Harvard Univ, Sch Med, Dept Biostat, Boston, MA USA. [Lange, Nicholas] McLean Hosp, Neurostat Lab, Belmont, MA 02178 USA. [Lainhart, Janet] Univ Wisconsin, Dept Psychiat, Div Child & Adolescent Psychiat, Madison, WI 53706 USA. RP Prigge, MD (reprint author), Univ Utah, Dept Psychiat, 650 Komas Dr Suite 206, Salt Lake City, UT 84108 USA. EM molly.dubray@hsc.utah.edu FU NRSA Predoctoral Fellowship NIH NIDCD [F31 DC010143]; NIH NIDCD [T32 DC008553]; NIH [RO1 NIMH MH080826, RO1 MH084795] FX We sincerely thank the participants and families for their time and participation. This research was supported by NRSA Predoctoral Fellowship NIH NIDCD F31 DC010143 (MDP), NIH NIDCD T32 DC008553, NIH RO1 NIMH MH080826, and NIH RO1 MH084795. Past data collection was supported in part by NICHD/NIDCD U19 HD035476, part of the CPEA. We thank Annahir Cariello and Jason Cooperrider for their assistance, and we acknowledge the contributions of William McMahon, Judith Miller, Michael Johnson, Jubel Morgan, and Jeffrey Lu in early stages of this work. The content of this project is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Mental Health, NICHD, NIDCD, or National Institutes of Health. CR AKAIKE H, 1974, IEEE T AUTOMAT CONTR, VAC19, P716, DOI 10.1109/TAC.1974.1100705 American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Ashburner J, 2008, AM J OCCUP THER, V62, P564 Boddaert N, 2003, AM J PSYCHIAT, V160, P2057, DOI 10.1176/appi.ajp.160.11.2057 Bruneau N, 1999, CLIN NEUROPHYSIOL, V110, P1927, DOI 10.1016/S1388-2457(99)00149-2 Bruneau N, 2003, INT J PSYCHOPHYSIOL, V51, P17, DOI 10.1016/S0167-8760(03)00149-1 Cardy JEO, 2005, NEUROREPORT, V16, P521 Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099 Ceponiene R, 2003, P NATL ACAD SCI USA, V100, P5567, DOI 10.1073/pnas.0835631100 Cohen J., 2003, APPL MULTIPLE REGRES Dale AM, 1999, NEUROIMAGE, V9, P179, DOI 10.1006/nimg.1998.0395 Devlin JT, 2003, J NEUROSCI, V23, P11516 Dunn M., 1999, SENSORY PROFILE Eisenmajer R, 1998, J AUTISM DEV DISORD, V28, P527, DOI 10.1023/A:1026004212375 Elliott C. D., 1990, DIFFERENTIAL ABILITY Emmorey K, 2003, P NATL ACAD SCI USA, V100, P10049, DOI 10.1073/pnas.1730169100 Fischl B, 2004, CEREB CORTEX, V14, P11, DOI 10.1093/cercor/bhg087 Flagg EJ, 2005, NEUROSCI LETT, V386, P82, DOI 10.1016/j.neulet.2005.05.037 Gage NM, 2009, J NEURODEV DISORD, V1, P205, DOI 10.1007/s11689-009-9010-2 Gage NM, 2003, NEUROREPORT, V14, P2047, DOI 10.1097/01.wnr.0000090030.460874a Gage NM, 2003, DEV BRAIN RES, V144, P201, DOI 10.1016/S0165-3806(03)00172-X GALABURDA A, 1980, J COMP NEUROL, V190, P597, DOI 10.1002/cne.901900312 GALABURDA AM, 1978, SCIENCE, V199, P852, DOI 10.1126/science.341314 GALABURDA AM, 1978, ARCH NEUROL-CHICAGO, V35, P812 Giedd JN, 2004, ANN NY ACAD SCI, V1021, P77, DOI 10.1196/annals.1308.009 Gogtay N, 2004, P NATL ACAD SCI USA, V101, P8174, DOI 10.1073/pnas.0402680101 Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Herbert MR, 2005, BRAIN, V128, P213, DOI 10.1093/brain/awh330 Huttenlocher PR, 1997, J COMP NEUROL, V387, P167, DOI 10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z Hyde KL, 2010, HUM BRAIN MAPP, V31, P556, DOI 10.1002/hbm.20887 Kanner L, 1943, NERV CHILD, V2, P217 Kasai K, 2005, CLIN NEUROPHYSIOL, V116, P1655, DOI 10.1016/j.clinph.2005.03.007 Kern JK, 2007, AUTISM, V11, P123, DOI 10.1177/1362361307075702 Kern JK, 2006, AUTISM, V10, P480, DOI 10.1177/1362361306066564 Knaus TA, 2009, BRAIN IMAGING BEHAV, V3, P51, DOI 10.1007/s11682-008-9048-x Kotecha R, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004811 Kraemer HC, 2000, AM J PSYCHIAT, V157, P163, DOI 10.1176/appi.ajp.157.2.163 Kuhl PK, 2004, NAT REV NEUROSCI, V5, P831, DOI 10.1038/nrn1533 Lepisto T, 2007, NEUROSCI LETT, V414, P136, DOI 10.1016/j.neulet.2006.12.009 Lepisto T, 2005, BRAIN RES, V1066, P147, DOI 10.1016/j.brainres.2005.10.052 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lord M, 1994, J AUTISM DEV DISORD, V24, P659 Matsuzaki J, 2012, NEUROREPORT, V23, P113, DOI 10.1097/WNR.0b013e32834ebf44 Moore JK, 2007, INT J AUDIOL, V46, P460, DOI 10.1080/14992020701383019 Moore JK, 2001, JARO, V2, P297, DOI 10.1007/s101620010052 Moore JK, 2002, ANN OTO RHINOL LARYN, V111, P7 Mullen E, 1995, MULLEN SCALES EARLY Muller RA, 1999, J AUTISM DEV DISORD, V29, P19, DOI 10.1023/A:1025914515203 OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4 O'Riordan M, 2006, J AUTISM DEV DISORD, V36, P665, DOI 10.1007/s10803-006-0106-1 Penhune VB, 1996, CEREB CORTEX, V6, P661, DOI 10.1093/cercor/6.5.661 Prastawa M, 2004, MED IMAGE ANAL, V8, P275, DOI 10.1016/j.media.2004.06.007 Rademacher J, 2001, NEUROIMAGE, V13, P669, DOI 10.1006/nimg.2000.0714 Roberts TPL, 2008, INT J PSYCHOPHYSIOL, V68, P149, DOI 10.1016/j.ijpsycho.2008.01.012 Roberts TPL, 2011, BIOL PSYCHIAT, V70, P263, DOI 10.1016/j.biopsych.2011.01.015 Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111 Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7 Rojas DC, 2002, NEUROSCI LETT, V328, P237, DOI 10.1016/S0304-3940(02)00521-9 Rojas DC, 2005, J AUTISM DEV DISORD, V35, P479, DOI 10.1007/s10803-005-5038-7 Rojas DC, 1997, AM J PSYCHIAT, V154, P1655 Samson F, 2011, NEUROPSYCHOLOGIA, V49, P546, DOI 10.1016/j.neuropsychologia.2010.12.033 Segonne F, 2004, NEUROIMAGE, V22, P1060, DOI 10.1016/j.neuroimage.2004.03.032 Shaw P, 2008, J NEUROSCI, V28, P3586, DOI 10.1523/JNEUROSCI.5309-07.2008 Sigalovsky IS, 2006, NEUROIMAGE, V32, P1524, DOI 10.1016/j.neuroimage.2006.05.023 Tomchek SD, 2007, AM J OCCUP THER, V61, P190 Upadhyay J, 2008, J NEUROSCI, V28, P3341, DOI 10.1523/JNEUROSCI.4434-07.2008 Van Leemput K, 1999, IEEE T MED IMAGING, V18, P897, DOI 10.1109/42.811270 Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd Wiggins LD, 2009, J AUTISM DEV DISORD, V39, P1087, DOI 10.1007/s10803-009-0711-x Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002 Yu KK, 2011, J PSYCHIATR NEUROSCI, V36, P412, DOI 10.1503/jpn.100138 Yushkevich PA, 2006, NEUROIMAGE, V31, P1116, DOI 10.1016/j.neuroimage.2006.01.015 NR 72 TC 3 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2013 VL 6 IS 2 BP 78 EP 90 DI 10.1002/aur.1265 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 133DL UT WOS:000318117500002 PM 23436773 ER PT J AU Miller, M Bales, KL Taylor, SL Yoon, J Hostetler, CM Carter, CS Solomon, M AF Miller, Meghan Bales, Karen L. Taylor, Sandra L. Yoon, Jong Hostetler, Caroline M. Carter, Cameron S. Solomon, Marjorie TI Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms SO AUTISM RESEARCH LA English DT Article DE neuropeptides; oxytocin; vasopressin; autism; sex differences; repetitive behaviors; anxiety ID OBSESSIVE-COMPULSIVE DISORDER; PLASMA ARGININE-VASOPRESSIN; RECEPTOR GENE OXTR; MALE PRAIRIE VOLES; SOCIAL-BEHAVIOR; CEREBROSPINAL-FLUID; HUMAN HYPOTHALAMUS; MAJOR DEPRESSION; KNOCKOUT MICE; HUMANS AB There has been intensified interest in the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in autism spectrum disorders (ASD) given their role in affiliative and social behavior in animals, positive results of treatment studies using OT, and findings that genetic polymorphisms in the AVPOT pathway are present in individuals with ASD. Nearly all such studies in humans have focused only on males. With this preliminary study, we provide basic and novel information on the involvement of OT and AVP in autism, with an investigation of blood plasma levels of these neuropeptides in 75 preadolescent and adolescent girls and boys ages 818: 40 with high-functioning ASD (19 girls, 21 boys) and 35 typically developing children (16 girls, 19 boys). We related neuropeptide levels to social, language, repetitive behavior, and internalizing symptom measures in these individuals. There were significant gender effects: Girls showed higher levels of OT, while boys had significantly higher levels of AVP. There were no significant effects of diagnosis on OT or AVP. Higher OT values were associated with greater anxiety in all girls, and with better pragmatic language in all boys and girls. AVP levels were positively associated with restricted and repetitive behaviors in girls with ASD but negatively (nonsignificantly) associated with these behaviors in boys with ASD. Our results challenge the prevailing view that plasma OT levels are lower in individuals with ASD, and suggest that there are distinct and sexually dimorphic mechanisms of action for OT and AVP underlying anxiety and repetitive behaviors. Autism Res 2013, 6: 91102. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Miller, Meghan] Univ Calif Berkeley, Dept Psychol, Berkeley, CA USA. [Miller, Meghan; Solomon, Marjorie] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA. [Bales, Karen L.; Hostetler, Caroline M.] Univ Calif Davis, Dept Psychol, Davis, CA USA. [Taylor, Sandra L.] Univ Calif Davis, Sch Med, Clin & Translat Sci Ctr, Sacramento, CA 95817 USA. [Yoon, Jong; Carter, Cameron S.; Solomon, Marjorie] Univ Calif Davis, Imaging Res Ctr, Sacramento, CA 95817 USA. RP Solomon, M (reprint author), Univ Calif Davis, MIND Inst, 2825 50th St, Sacramento, CA 95817 USA. EM marjorie.solomon@ucdmc.ucdavis.edu FU NIMH [K08 MH074967-01]; BIRCWH award [K12 HD051958] FX This work was supported by K08 MH074967-01 from NIMH and a BIRCWH award, (K12 HD051958), to Marjorie Solomon. Statistical support was made possible by UL1 RR024246 from the National Center for Research Resources, a component of the NIH and NIH Roadmap for Medical Research. The authors report no conflicts of interest. CR Al-Ayadhi Laila Y, 2005, Neurosciences (Riyadh), V10, P47 American Psychiatric Association, 2000, DIAGN STAT MAN MENT AMICO JA, 1990, J CLIN ENDOCR METAB, V71, P1531 Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107 ARGIOLAS A, 1991, NEUROSCI BIOBEHAV R, V15, P217, DOI 10.1016/S0149-7634(05)80002-8 ASPLUND R, 1991, J INTERN MED, V229, P131 Bao AM, 2008, BRAIN RES REV, V57, P531, DOI 10.1016/j.brainresrev.2007.04.005 Bartz JA, 2010, PSYCHOL SCI, V21, P1426, DOI 10.1177/0956797610383439 Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444 Bishop D. V. M., 2003, CHILDRENS COMMUNICAT Bitan T, 2010, J NEUROSCI, V30, P11576, DOI 10.1523/JNEUROSCI.1245-10.2010 Bodfish J. W., 1999, W CAROLINA CTR RES R Born J, 2002, NAT NEUROSCI, V5, P514, DOI 10.1038/nn849 Boso M, 2007, ARCH MED RES, V38, P70, DOI 10.1016/j.arcmed.2006.08.003 Carter CS, 2007, BEHAV BRAIN RES, V176, P170, DOI 10.1016/j.bbr.2006.08.025 Choleris E, 2003, P NATL ACAD SCI USA, V100, P6192, DOI 10.1073/pnas.0631699100 Constantino JN, 2002, SOCIAL RESPONSIVENES Cyranowski JM, 2008, PSYCHOSOM MED, V70, P967, DOI 10.1097/PSY.0b013e318188ade4 de Kloet CS, 2008, J PSYCHIATR RES, V42, P192, DOI 10.1016/j.jpsychires.2006.11.009 De Vries GJ, 2006, NEUROSCIENCE, V138, P947, DOI 10.1016/j.neuroscience.2005.07.050 Domes G, 2007, BIOL PSYCHIAT, V61, P731, DOI 10.1016/j.biopsych.2006.07.015 Donaldson ZR, 2009, BIOL REPROD, V81, P1189, DOI 10.1095/biolreprod.109.077529 Donaldson ZR, 2008, SCIENCE, V322, P900, DOI 10.1126/science.1158668 Ebstein RP, 2009, ANN NY ACAD SCI, V1167, P87, DOI 10.1111/j.1749-6632.2009.04541.x Feldman R, 2007, PSYCHOL SCI, V18, P965, DOI 10.1111/j.1467-9280.2007.02010.x Feldman R, 2010, PSYCHONEUROENDOCRINO, V35, P1133, DOI 10.1016/j.psyneuen.2010.01.013 Fries ABW, 2005, P NATL ACAD SCI USA, V102, P17237, DOI 10.1073/pnas.0504767102 Gimpl G, 2001, PHYSIOL REV, V81, P629 Grippo A. J., 2008, PSYCHONEUROENDOCRINO, V34, P1542 Grippo AJ, 2007, PSYCHONEUROENDOCRINO, V32, P966, DOI 10.1016/j.psyneuen.2007.07.004 Guastella AJ, 2008, BIOL PSYCHIAT, V64, P256, DOI 10.1016/j.biopsych.2008.02.008 Guastella AJ, 2010, BIOL PSYCHIAT, V67, P692, DOI 10.1016/j.biopsych.2009.09.020 Hammock EAD, 2006, PHILOS T R SOC B, V361, P2187, DOI 10.1098/rstb.2006.1939 Hammock EAD, 2005, SCIENCE, V308, P1630, DOI 10.1126/science.1111427 Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021 Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030 Insel TR, 1999, BIOL PSYCHIAT, V45, P145, DOI 10.1016/S0006-3223(98)00142-5 Insel TR, 2010, NEURON, V65, P768, DOI 10.1016/j.neuron.2010.03.005 Insel TR, 2004, ANNU REV NEUROSCI, V27, P697, DOI 10.1146/annurev.neuro.27.070203.144148 Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001 Kenkel WM, 2012, J NEUROENDOCRINOL, V24, P874, DOI 10.1111/j.1365-2826.2012.02301.x Keverne EB, 2004, CURR OPIN NEUROBIOL, V14, P777, DOI 10.1016/j.conb.2004.10.006 Kim SJ, 2002, MOL PSYCHIATR, V7, P503, DOI 10.1038/sj.mp.4001125 Kiss A, 2010, J NEUROSCI RES, V88, P677, DOI 10.1002/jnr.22226 Kosfeld M, 2005, NATURE, V435, P673, DOI 10.1038/nature03701 Kramer KM, 2004, CAN J ZOOL, V82, P1194, DOI 10.1139/Z04-098 Landgraf R, 2004, FRONT NEUROENDOCRIN, V25, P150, DOI 10.1016/j.yfrne.2004.05.001 LEBOYER M, 1992, J AUTISM DEV DISORD, V22, P309, DOI 10.1007/BF01058158 LECKMAN JF, 1994, ARCH GEN PSYCHIAT, V51, P782 Levine Ari, 2007, Peptides, V28, P1162, DOI 10.1016/j.peptides.2007.04.016 Liu XX, 2010, J HUM GENET, V55, P137, DOI 10.1038/jhg.2009.140 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Macintosh KE, 2004, J CHILD PSYCHOL PSYC, V45, P421, DOI 10.1111/j.1469-7610.2004.00234.x McCarthy MM, 1996, PHYSIOL BEHAV, V60, P1209 Meynen G, 2006, BIOL PSYCHIAT, V60, P892, DOI 10.1016/j.biopsych.2005.12.010 Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3 Naber F, 2010, PSYCHONEUROENDOCRINO, V35, P1583, DOI 10.1016/j.psyneuen.2010.04.007 Neumann J. D., 2000, PROGR BRAIN RES, V139, P147 Norman GJ, 2011, BIOL PSYCHOL, V86, P174, DOI 10.1016/j.biopsycho.2010.11.006 Ozonoff S., 2000, ASPERGER SYNDROME, P24 Pobbe RLH, 2012, HORM BEHAV, V61, P436, DOI 10.1016/j.yhbeh.2011.10.010 Purba JS, 1996, ARCH GEN PSYCHIAT, V53, P137 Reynolds C. R., 2004, BEHAV ASSESSMENT SYS, V2nd Ring RH, 2010, NEUROPHARMACOLOGY, V58, P69, DOI [10.1016/j.neuropharm.2009.07.016, 10.1016/j.neuropharm.2009.08.015] Rodgers J, 2012, J AUTISM DEV DISORD, V42, P175, DOI 10.1007/s10803-011-1225-x Rutter M., 2003, SCQ SOCIAL COMMUNICA Savaskan E, 2008, PSYCHONEUROENDOCRINO, V33, P368, DOI 10.1016/j.psyneuen.2007.12.004 Schneiderman I, 2012, PSYCHONEUROENDOCRINO, V37, P1277, DOI 10.1016/j.psyneuen.2011.12.021 Seltzer LJ, 2010, P ROY SOC B-BIOL SCI, V277, P2661, DOI 10.1098/rspb.2010.0567 Solomon M, 2008, J AUTISM DEV DISORD, V38, P1474, DOI 10.1007/s10803-007-0526-6 Solomon M, 2012, J AUTISM DEV DISORD, V42, P48, DOI 10.1007/s10803-011-1215-z SWEDO SE, 1992, ARCH GEN PSYCHIAT, V49, P29 Taylor SE, 2006, PSYCHOSOM MED, V68, P238, DOI 10.1097/01.psy.0000203242.95990.74 Tenenbaum H. R., 2010, BRIT J DEV PSYCHOL, V29, P238 vanLonden L, 1997, NEUROPSYCHOPHARMACOL, V17, P284, DOI 10.1016/S0893-133X(97)00054-7 van Londen L, 1998, BIOL PSYCHIAT, V43, P196, DOI 10.1016/S0006-3223(97)80433-7 WANG ZX, 1994, P NATL ACAD SCI USA, V91, P400, DOI 10.1073/pnas.91.1.400 Wassink TH, 2004, MOL PSYCHIATR, V9, P968, DOI 10.1038/sj.mp.4001503 Wechsler D, 1999, WECHSLER ABBREVIATED Weisman O., PSYCHONEURO IN PRESS WERMTER AK, 2009, AM J MED GENET B, V153, P629 Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013 Yirmiya N, 2006, MOL PSYCHIATR, V11, P488, DOI 10.1038/sj.mp.4001812 Ylisaukko-oja T, 2006, ANN NEUROL, V59, P145, DOI 10.1002/ana.20722 NR 85 TC 17 Z9 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2013 VL 6 IS 2 BP 91 EP 102 DI 10.1002/aur.1270 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 133DL UT WOS:000318117500003 PM 23413037 ER PT J AU Yoder, PJ Oller, DK Richards, JA Gray, S Gilkerson, J AF Yoder, Paul J. Oller, D. Kimbrough Richards, Jeffrey A. Gray, Sharmistha Gilkerson, Jill TI Stability and Validity of an Automated Measure of Vocal Development From Day-Long Samples in Children With and Without Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE infants; pediatrics; developmental psychology; clinical psychology ID LANGUAGE AB Individual difference measures of vocal development may eventually aid our understanding of the variability in spoken language acquisition in children with autism spectrum disorder (ASD). Large samples of child vocalizations may be needed to maximize the stability of vocal development estimates. Day-long vocal samples can now be automatically analyzed based on acoustic characteristics of speech likeness identified in theoretically driven and empirically cross-validated quantitative models of typical vocal development. This report indicates that a single day-long recording can produce a stable estimate for a measure of vocal development that is highly related to expressive spoken language in a group of young children with ASD and in a group that is typically developing. Autism Res 2013, 6: 103107. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Yoder, Paul J.] Vanderbilt Univ, Dept Special Educ, Nashville, TN 37203 USA. [Oller, D. Kimbrough] Univ Memphis, Sch Commun Sci & Disorders, Memphis, TN 38152 USA. [Oller, D. Kimbrough] Konrad Lorenz Inst Evolut & Cognit Res, Altenberg, Austria. [Richards, Jeffrey A.; Gilkerson, Jill] LENA Res Fdn, Boulder, CO USA. [Gilkerson, Jill] Univ Colorado, Boulder, CO 80309 USA. RP Yoder, PJ (reprint author), Vanderbilt Univ, 228 Peabody Box, Nashville, TN 37203 USA. EM paul.yoder@vanderbilt.edu FU NIDCD [R01 DC011027]; NICHD [P30HD15052]; Plough Foundation FX This research was supported by NIDCD R01 DC011027 to D. K. Oller, and NICHD Grant P30HD15052 to the Vanderbilt Kennedy Center for Research on Human Development, and the Plough Foundation. The LENA Research Foundation generously provided the data for this article. We are grateful to the families who participated in the original LENA research. CR Cronbach L. J., 1972, DEPENDABILITY BEHAV CRONBACH LJ, 1955, PSYCHOL BULL, V52, P281, DOI 10.1037/h0040957 Ghiselli E, 1981, MEASUREMENT THEORY B Ireton H, 1992, CHILD DEV INVENTORY Oller D. K., 2000, EMERGENCE SPEECH CAP Oller DK, 2010, P NATL ACAD SCI USA, V107, P13354, DOI 10.1073/pnas.1003882107 Paul R, 2011, J CHILD PSYCHOL PSYC, V52, P588, DOI 10.1111/j.1469-7610.2010.02332.x RESCORLA L, 1989, J SPEECH HEAR DISORD, V54, P587 Shavelson R. J., 1991, GENERALIZABILITY THE Sheinkopf SJ, 2000, J AUTISM DEV DISORD, V30, P345, DOI 10.1023/A:1005531501155 Warren SF, 2010, J AUTISM DEV DISORD, V40, P555, DOI 10.1007/s10803-009-0902-5 Yoder P, 2010, OBSERVATIONAL MEASUR NR 12 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2013 VL 6 IS 2 BP 103 EP 107 DI 10.1002/aur.1271 PG 5 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 133DL UT WOS:000318117500004 PM 23436778 ER PT J AU Grubb, MA Behrmann, M Egan, R Minshew, NJ Carrasco, M Heeger, DJ AF Grubb, Michael A. Behrmann, Marlene Egan, Ryan Minshew, Nancy J. Carrasco, Marisa Heeger, David J. TI Endogenous Spatial Attention: Evidence for Intact Functioning in Adults With Autism SO AUTISM RESEARCH LA English DT Article DE attention; spatial attention; endogenous attention; psychophysics; adults; autism; autism spectrum disorders; ASD ID INCREASES CONTRAST SENSITIVITY; HUMAN VISUAL-CORTEX; COVERT ATTENTION; SELECTIVE ATTENTION; SUSTAINED ATTENTION; RESPONSE FUNCTIONS; ZOOM LENS; DEFICITS; PERFORMANCE; CHILDREN AB Rapid manipulation of the attention field (i.e. the location and spread of visual spatial attention) is a critical aspect of human cognition, and previous research on spatial attention in individuals with autism spectrum disorders (ASD) has produced inconsistent results. In a series of three psychophysical experiments, we evaluated claims in the literature that individuals with ASD exhibit a deficit in voluntarily controlling the deployment and size of the spatial attention field. We measured the spatial distribution of performance accuracies and reaction times to quantify the sizes and locations of the attention field, with and without spatial uncertainty (i.e. the lack of predictability concerning the spatial position of the upcoming stimulus). We found that high-functioning adults with autism exhibited slower reaction times overall with spatial uncertainty, but the effects of attention on performance accuracies and reaction times were indistinguishable between individuals with autism and typically developing individuals in all three experiments. These results provide evidence of intact endogenous spatial attention function in high-functioning adults with ASD, suggesting that atypical endogenous attention cannot be a latent characteristic of autism in general. Autism Res 2013, 6: 108118. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Grubb, Michael A.; Carrasco, Marisa; Heeger, David J.] NYU, Dept Psychol, New York, NY 10003 USA. [Behrmann, Marlene; Egan, Ryan] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA. [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA. [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA. [Carrasco, Marisa; Heeger, David J.] NYU, Ctr Neural Sci, New York, NY 10003 USA. RP Heeger, DJ (reprint author), NYU, Dept Psychol, Washington Pl,8th Floor, New York, NY 10003 USA. EM david.heeger@nyu.edu FU NIH [R01-EY019693]; SFARI [177638]; ACE [HD055748]; Autism Speaks Predoctoral Fellowship [7831] FX This research was supported by NIH Grant R01-EY019693 to D. H. and M. C., by SFARI Grant 177638 to D. H. and M. B., by ACE Grant HD055748 to N.M., and by Autism Speaks Predoctoral Fellowship 7831 to M.G. CR Alais D, 1999, VISION RES, V39, P4341, DOI 10.1016/S0042-6989(99)00146-7 Ames C, 2010, DEV REV, V30, P52, DOI 10.1016/j.dr.2009.12.003 Belopolsky AV, 2007, PSYCHON B REV, V14, P934, DOI 10.3758/BF03194124 Braun J, 1998, NATURE, V393, P424, DOI 10.1038/30875 BURACK JA, 1994, J ABNORM PSYCHOL, V103, P535, DOI 10.1037/0021-843X.103.3.535 Carrasco M, 2011, VISION RES, V51, P1484, DOI 10.1016/j.visres.2011.04.012 Carrasco M, 2001, P NATL ACAD SCI USA, V98, P5363, DOI 10.1073/pnas.081074098 Carrasco M, 2006, VISION RES, V46, P2028, DOI 10.1016/j.visres.2005.12.015 Carrasco M, 2006, PROG BRAIN RES, V154, P33 Carrasco M, 2000, VISION RES, V40, P1203, DOI 10.1016/S0042-6989(00)00024-9 Cavanagh P, 2005, TRENDS COGN SCI, V9, P349, DOI 10.1016/j.tics.2005.05.009 ERIKSEN CW, 1986, PERCEPT PSYCHOPHYS, V40, P225, DOI 10.3758/BF03211502 Giordano AM, 2009, J VISION, V9, DOI 10.1167/9.3.30 Gowen E., 2012, J AUTISM DEV DISORDE Harris NS, 1999, COGNITIVE BRAIN RES, V8, P61, DOI 10.1016/S0926-6410(99)00006-3 Herrmann K, 2012, VISION RES, V74, P10, DOI 10.1016/j.visres.2012.04.016 Herrmann K, 2010, NAT NEUROSCI, V13, P1554, DOI 10.1038/nn.2669 James W, 1890, PRINCIPLES PSYCHOL Kimchi R, 2008, PSYCHOL SCI, V19, P660, DOI 10.1111/j.1467-9280.2008.02140.x Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x Li X, 2008, P NATL ACAD SCI USA, V105, P6202, DOI 10.1073/pnas.0801390105 Ling S, 2006, NAT NEUROSCI, V9, P1243, DOI 10.1038/nn1761 Ling S, 2006, VISION RES, V46, P1210, DOI 10.1016/j.visres.2005.05.008 Liu TS, 2005, NEURON, V45, P469, DOI 10.1016/j.neuron.2004.12.039 Liu TS, 2007, VISION RES, V47, P108, DOI 10.1016/j.visres.2006.09.017 Lu ZL, 2000, J EXP PSYCHOL HUMAN, V26, P1534, DOI 10.1037//0096-1523.26.5.1534 Mann TA, 2003, J CHILD PSYCHOL PSYC, V44, P274, DOI 10.1111/1469-7610.00120 Muller NG, 2003, J NEUROSCI, V23, P3561 NAKAYAMA K, 1989, VISION RES, V29, P1631, DOI 10.1016/0042-6989(89)90144-2 Pestilli F, 2009, VISION RES, V49, P1144, DOI 10.1016/j.visres.2008.09.018 Pestilli F, 2011, NEURON, V72, P832, DOI 10.1016/j.neuron.2011.09.025 Pestilli F, 2005, VISION RES, V45, P1867, DOI 10.1016/j.visres.2005.01.019 POSNER MI, 1980, J EXP PSYCHOL GEN, V109, P160, DOI 10.1037//0096-3445.109.2.160 REED AV, 1973, SCIENCE, V181, P574, DOI 10.1126/science.181.4099.574 Remington A, 2009, PSYCHOL SCI, V20, P1388, DOI 10.1111/j.1467-9280.2009.02454.x Renner P, 2006, CHILD NEUROPSYCHOL, V12, P361, DOI 10.1080/09297040600770753 Senju A, 2004, J CHILD PSYCHOL PSYC, V45, P445, DOI 10.1111/j.1469-7610.2004.00236.x SPERLING G, 1978, SCIENCE, V202, P315, DOI 10.1126/science.694536 TOWNSEND J, 1994, J COGNITIVE NEUROSCI, V6, P220, DOI 10.1162/jocn.1994.6.3.220 Townsend J, 1999, J NEUROSCI, V19, P5632 Townsend J, 1996, DEV PSYCHOPATHOL, V8, P563 Verghese P, 2001, NEURON, V31, P523, DOI 10.1016/S0896-6273(01)00392-0 Wainwright JA, 1996, J AUTISM DEV DISORD, V26, P423, DOI 10.1007/BF02172827 WAINWRIGHTSHARP JA, 1993, J AUTISM DEV DISORD, V23, P1, DOI 10.1007/BF01066415 Wechsler D, 1999, WECHSLER ABBREVIATED WICKELGREN WA, 1977, ACTA PSYCHOL, V41, P67, DOI 10.1016/0001-6918(77)90012-9 YANTIS S, 1984, J EXP PSYCHOL HUMAN, V10, P601, DOI 10.1037/0096-1523.10.5.601 Yeshurun Y, 2008, VISION RES, V48, P80, DOI 10.1016/j.visres.2007.10.015 NR 48 TC 4 Z9 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2013 VL 6 IS 2 BP 108 EP 118 DI 10.1002/aur.1269 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 133DL UT WOS:000318117500005 PM 23427075 ER PT J AU Baruth, JM Wall, CA Patterson, MC Port, JD AF Baruth, Joshua M. Wall, Christopher A. Patterson, Marc C. Port, John D. TI Proton Magnetic Resonance Spectroscopy as a Probe into the Pathophysiology of Autism Spectrum Disorders (ASD): A Review SO AUTISM RESEARCH LA English DT Review DE Autism Spectrum Disorders; proton magnetic resonance spectroscopy; N-acetylaspartate; glutamate; myo-inositol ID N-ACETYL ASPARTATE; WHITE-MATTER; HUMAN BRAIN; ASPERGER-SYNDROME; MR SPECTROSCOPY; LOCALIZED PROTON; DOUBLE-BLIND; MITOCHONDRIAL DYSFUNCTION; MINICOLUMNAR PATHOLOGY; CEREBELLAR CORTICES AB Proton magnetic resonance spectroscopy (1H-MRS) is a safe, noninvasive way of quantifying in vivo biochemical and metabolite concentration levels in individuals with Autism Spectrum Disorders (ASD). Findings to date suggest ASD is associated with widespread reduction in N-acetylaspartate (NAA), creatine plus phosphocreatine (Cr), choline-containing compounds (Cho), myo-inositol (mI), and glutamate plus glutamine plus gamma-Aminobutyric Acid (Glx); however, variable findings, and even substantial increases, are not uncommon depending on the study and/or region-of-interest. Widespread reduction of NAA, Cr, Cho, mI, and Glx in ASD likely reflects impaired neuronal function and/or metabolism related to abnormal neurodevelopmental processes. Future studies should attempt to relate 1H-MRS findings to histological findings and control for variability in subject age and functioning level; this would assist in evaluating the relationship between 1H-MRS metabolic levels and neuronal and glial cell densities, as well as neurodevelopmental process associated with ASD. Furthermore, more longitudinal 1H-MRS studies are needed in both control and ASD subjects to attempt to standardize metabolite levels across different developmental periods in well-defined endophenotypes. This will provide for a standard rubric for which metabolic aberrations (as well as treatment responses) can be measured. With higher magnetic field strengths and spectral-editing techniques capable of quantifying less-concentrated metabolites, 1H-MRS will continue to be an important tool in ASD research. Autism Res 2013, 6: 119133. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Baruth, Joshua M.; Wall, Christopher A.; Port, John D.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN 55905 USA. [Patterson, Marc C.] Mayo Clin, Childrens Ctr, Dept Neurol, Rochester, MN 55905 USA. [Patterson, Marc C.] Mayo Clin, Childrens Ctr, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA. [Patterson, Marc C.] Mayo Clin, Childrens Ctr, Dept Med Genet, Rochester, MN 55905 USA. [Port, John D.] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA. RP Baruth, JM (reprint author), Mayo Clin, Dept Psychiat & Psychol, 200 1st St SW, Rochester, MN 55905 USA. EM jmbaru01@louisville.edu RI Port, John/I-7940-2014 OI Port, John/0000-0002-4237-7776 FU Mayo Clinic Department of Psychiatry and Psychology FX The authors have no conflicts of interest to declare. We would like to thank the Mayo Clinic Department of Psychiatry and Psychology, and especially Mark Frye, MD and Peter Jensen, MD for support of this project. CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Arai T, 1996, BRAIN RES, V743, P131, DOI 10.1016/S0006-8993(96)00854-2 ARNOLD DL, 1992, ANN NEUROL, V31, P235, DOI 10.1002/ana.410310302 Assaf M, 2010, NEUROIMAGE, V53, P247, DOI 10.1016/j.neuroimage.2010.05.067 Babikian T, 2010, J NEUROTRAUM, V27, P473, DOI 10.1089/neu.2009.1058 Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x Bartha R, 2000, MAGNET RESON MED, V44, P185 Baruth JM, 2010, J NEUROTHERAPY, V14, P179, DOI DOI 10.1080/10874208.2010.501500 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Belsito KM, 2001, J AUTISM DEV DISORD, V31, P175, DOI 10.1023/A:1010799115457 Bernardi S, 2011, BRAIN RES, V1380, P198, DOI 10.1016/j.brainres.2010.12.057 BIRKEN DL, 1989, NEUROSCI BIOBEHAV R, V13, P23, DOI 10.1016/S0149-7634(89)80048-X Bluml S, 1999, MAGNET RESON MED, V42, P643, DOI 10.1002/(SICI)1522-2594(199910)42:4<643::AID-MRM5>3.0.CO;2-N Boddaert N, 2002, PEDIATR RADIOL, V32, P1 BRAND A, 1993, DEV NEUROSCI-BASEL, V15, P289, DOI 10.1159/000111347 Casanova MF, 2007, BRAIN PATHOL, V17, P422, DOI 10.1111/j.1750-3639.2007.00100.x Casanova MF, 2002, NEUROLOGY, V58, P428 Casanova MF, 2002, J CHILD NEUROL, V17, P692, DOI 10.1177/088307380201700908 Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5 Chakraborty G, 2001, J NEUROCHEM, V78, P736, DOI 10.1046/j.1471-4159.2001.00456.x Choudhury PR, 2012, PHARMACOL BIOCHEM BE, V100, P841, DOI 10.1016/j.pbb.2011.06.023 Chugani DC, 1999, PROG NEURO-PSYCHOPH, V23, P635, DOI 10.1016/S0278-5846(99)00022-6 Clark JB, 1998, DEV NEUROSCI-BASEL, V20, P271, DOI 10.1159/000017321 Cook EH, 1998, AM J HUM GENET, V62, P1077, DOI 10.1086/301832 Corrigan NM, 2012, J AUTISM DEV DISORD, V42, P105, DOI 10.1007/s10803-011-1216-y Courchesne E, 2005, INT J DEV NEUROSCI, V23, P153, DOI 10.1016/j.ijdevneu.2005.01.003 Coyle J, 2002, NEUROPSYCHOPHARMACOL, P71 Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203 Daikhin Y., 2000, J NUTR, V130, P1026 DeVito TJ, 2007, BIOL PSYCHIAT, V61, P465, DOI 10.1016/j.biopsych.2006.07.022 Endo T, 2007, BIOL PSYCHIAT, V62, P1030, DOI 10.1016/j.biopsych.2007.05.015 Fatemi SH, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-6 Fatemi SH, 2009, CEREBELLUM, V8, P64, DOI 10.1007/s12311-008-0075-3 Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0 Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7 Fatemi SH, 2008, PROG NEURO-PSYCHOPH, V32, P911, DOI 10.1016/j.pnpbp.2007.11.004 Fayed N, 2005, ACAD RADIOL, V12, P566, DOI 10.1016/j.acra.2005.01.016 Friedman SD, 2003, NEUROLOGY, V60, P100 Friedman SD, 2006, ARCH GEN PSYCHIAT, V63, P786, DOI 10.1001/archpsyc.63.7.786 Friedman SD, 1999, NEUROLOGY, V52, P1384 Fujii Emiko, 2010, J Med Invest, V57, P35 Fux M, 1996, AM J PSYCHIAT, V153, P1219 Gabis L, 2008, J CHILD NEUROL, V23, P766, DOI 10.1177/0883073808315423 Gadian D. G., 1996, NMR ITS APPL LIVING Gomes Erissandra, 2008, Pro Fono, V20, P279 Govindaraju V, 2000, NMR BIOMED, V13, P129, DOI 10.1002/1099-1492(200005)13:3<129::AID-NBM619>3.3.CO;2-M Gupta RK, 2000, J NEURO-ONCOL, V50, P215, DOI 10.1023/A:1006431120031 Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76 Happe F, 1996, NEUROREPORT, V8, P197, DOI 10.1097/00001756-199612200-00040 Harada M, 2011, J AUTISM DEV DISORD, V41, P447, DOI 10.1007/s10803-010-1065-0 Hardan AY, 2008, PSYCHIAT RES-NEUROIM, V163, P97, DOI 10.1016/j.pscychresns.2007.12.002 Hashimoto T, 1998, ACTA NEUROL SCAND, V98, P8 Hashimoto T, 1997, J CHILD NEUROL, V12, P91 Hazlett HC, 2006, BIOL PSYCHIAT, V59, P1, DOI 10.1016/j.biopsych.2005.06.015 Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032 Hisaoka S, 2001, NEURORADIOLOGY, V43, P496 HORWITZ B, 1988, ARCH NEUROL-CHICAGO, V45, P749 Ipser JC, 2012, METAB BRAIN DIS, V27, P275, DOI 10.1007/s11011-012-9293-y Jansen JFA, 2006, RADIOLOGY, V240, P318, DOI 10.1148/radiol.2402050314 Kadota T, 2001, AM J NEURORADIOL, V22, P128 Kern JK, 2006, J TOXICOL ENV HEAL B, V9, P485, DOI 10.1080/10937400600882079 Kleinhans NM, 2011, NEUROIMAGE, V54, P697, DOI 10.1016/j.neuroimage.2010.07.037 Kleinhans NM, 2007, BRAIN RES, V1162, P85, DOI 10.1016/j.brainres.2007.04.081 KREIS R, 1993, MAGNET RESON MED, V30, P424, DOI 10.1002/mrm.1910300405 Kreis R, 2011, NMR BIOMED, V24, P253, DOI 10.1002/nbm.1582 Laurence JA, 2005, CEREBELLUM, V4, P206, DOI 10.1080/14734220500208846 LEVINE J, 1995, AM J PSYCHIAT, V152, P792 Levitt JG, 2003, BIOL PSYCHIAT, V54, P1355, DOI 10.1016/S0006-3223(03)00688-7 Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195 MacKay S, 1996, ARCH NEUROL-CHICAGO, V53, P167 McCaffery P, 2005, PROG NEUROBIOL, V77, P38, DOI 10.1016/j.pneurobio.2005.10.005 McKenna MC, 2007, J NEUROSCI RES, V85, P3347, DOI 10.1002/jnr.21444 MICHAELIS T, 1993, RADIOLOGY, V187, P219 Miller BL, 1996, LIFE SCI, V58, P1929, DOI 10.1016/0024-3205(96)00182-8 Mori Kenji, 2001, No To Hattatsu, V33, P329 Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012 Murphy DGM, 2002, ARCH GEN PSYCHIAT, V59, P885, DOI 10.1001/archpsyc.59.10.885 Nelson KB, 2001, ANN NEUROL, V49, P597, DOI 10.1002/ana.1024 Noriuchi M, 2010, BRAIN RES, V1362, P141, DOI 10.1016/j.brainres.2010.09.051 O'Brien FM, 2010, PSYCHIAT RES-NEUROIM, V184, P77, DOI 10.1016/j.pscychresns.2010.08.007 Otsuka H, 1999, NEURORADIOLOGY, V41, P517 Page LA, 2006, AM J PSYCHIAT, V163, P2189, DOI 10.1176/appi.ajp.163.12.2189 Palatnik A, 2001, J CLIN PSYCHOPHARM, V21, P335, DOI 10.1097/00004714-200106000-00014 Perich-Alsina J, 2002, Rev Neurol, V34 Suppl 1, pS68 Perry EK, 2001, AM J PSYCHIAT, V158, P1058, DOI 10.1176/appi.ajp.158.7.1058 Pfefferbaum A, 1999, MAGNET RESON MED, V41, P276, DOI 10.1002/(SICI)1522-2594(199902)41:2<276::AID-MRM10>3.0.CO;2-8 Pfund Z, 2000, J CEREBR BLOOD F MET, V20, P871 Prost RW, 1997, MAGNET RESON MED, V37, P615, DOI 10.1002/mrm.1910370422 Purcell AE, 2001, NEUROLOGY, V57, P1618 Redcay E, 2008, BIOL PSYCHIAT, V64, P589, DOI 10.1016/j.biopsych.2008.05.020 Redcay E, 2005, BIOL PSYCHIAT, V58, P1, DOI 10.1016/j.biopsych.2005.03.026 Rippon G, 2007, INT J PSYCHOPHYSIOL, V63, P164, DOI 10.1016/j.ijpsycho.2006.03.012 Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98 Ross B, 2001, ANAT REC, V265, P54, DOI 10.1002/ar.1058 ROSS B, 1994, MAGN RESON QUART, V10, P191 Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Rudkin TM, 1999, ARCH NEUROL-CHICAGO, V56, P919, DOI 10.1001/archneur.56.8.919 Samaco RC, 2005, HUM MOL GENET, V14, P483, DOI 10.1093/hmg/ddi045 Sansa G, 2011, EPILEPSIA, V52, P1071, DOI 10.1111/j.1528-1167.2011.03069.x Satlin A, 1997, AM J PSYCHIAT, V154, P1459 Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331 Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004 Serajee FJ, 2003, J MED GENET, V40, DOI 10.1136/jmg.40.4.e42 Shinohe A, 2006, PROG NEURO-PSYCHOPH, V30, P1472, DOI 10.1016/j.pnpbp.2006.06.013 Shukla DK, 2011, J CHILD PSYCHOL PSYC, V52, P286, DOI 10.1111/j.1469-7610.2010.02342.x Soher BJ, 1996, MAGNET RESON MED, V35, P356, DOI 10.1002/mrm.1910350313 Sokhadze E, 2010, APPL PSYCHOPHYS BIOF, V35, P147, DOI 10.1007/s10484-009-9121-2 Sokol DK, 2002, J CHILD NEUROL, V17, P245, DOI 10.1177/088307380201700401 Stanley JA, 2002, CAN J PSYCHIAT, V47, P315 Tzika AA, 1997, AM J NEURORADIOL, V18, P203 VANDERKNAAP MS, 1990, RADIOLOGY, V176, P509 Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315 Watanabe M, 2002, INT REV CYTOL, V213, P1 Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057 Wing L., 1997, AUTISM, V1, P13, DOI 10.1177/1362361397011004 Yoo HJ, 2012, NEUROSCI LETT, V512, P89, DOI 10.1016/j.neulet.2012.01.061 NR 118 TC 7 Z9 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2013 VL 6 IS 2 BP 119 EP 133 DI 10.1002/aur.1273 PG 15 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 133DL UT WOS:000318117500006 PM 23436782 ER PT J AU Sasson, NJ Lam, KSL Childress, D Parlier, M Daniels, JL Piven, J AF Sasson, Noah J. Lam, Kristen S. L. Childress, Debra Parlier, Morgan Daniels, Julie L. Piven, Joseph TI The Broad Autism Phenotype Questionnaire: Prevalence and Diagnostic Classification SO AUTISM RESEARCH LA English DT Article DE autism; Broad Autism Phenotype; assessment; prevalence; genetics ID EXPLORATORY FACTOR-ANALYSIS; MULTIPLE-INCIDENCE; COGNITIVE PHENOTYPE; GENERAL-POPULATION; FAMILY-HISTORY; PARENTS; CHILDREN; TRAITS; PERSONALITY; DISORDER AB The Broad Autism Phenotype Questionnaire (BAPQ) was administered to a large community-based sample of biological parents of children with autism (PCAs) and comparison parents (CPs) (n=1,692). Exploratory factor analysis and internal consistency parameters confirmed a robust three-factor structure of the BAPQ, corresponding to the proposed aloof, pragmatic language and rigidity subscales. Based upon the distribution of Broad Autism Phenotype (BAP) features in the general population, new normative cutoff values for BAPQ subscales were established that provide increased specificity relative to those previously reported, and thus enhance the utility of the BAPQ for diagnostically classifying the BAP. These cutoffs were also used to estimate prevalence of the BAP and its three components, with rates ranging between 1423% for PCAs and between 59% for CPs. Analysis of patterns of BAP characteristics within family members revealed that BAP features were more likely to co-occur in PCAs relative to CPs. Collectively, these findings extend the utility of the BAPQ and provide additional evidence that it is an efficient and reliable tool for disaggregating the heterogeneity of autism through the identification of meaningful subgroups of parents. Autism Res 2013, 6: 134143. (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Sasson, Noah J.] Univ Texas Dallas, Sch Behav & Brain Sci, Richardson, TX 78050 USA. [Lam, Kristen S. L.; Childress, Debra; Parlier, Morgan; Daniels, Julie L.; Piven, Joseph] Univ N Carolina, Sch Med, Carolina Inst Dev Disabil, Chapel Hill, NC USA. [Daniels, Julie L.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. RP Sasson, NJ (reprint author), Univ Texas Dallas, Sch Behav & Brain Sci GR41, Richardson, TX 78050 USA. EM nsasson@utdallas.edu; jpiven@med.unc.edu FU National Institutes of Health, IDDRC Participant Registry Core, P30 [HD003110]; Centers for Disease Control and Prevention [U10 DD000184-06, U50/CCU422345]; Research Registry Core of the Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at UNC-Chapel Hill [HD003110] FX Grant sponsor: National Institutes of Health, IDDRC Participant Registry Core, P30 # HD003110; Centers for Disease Control and Prevention, Grant numbers: U10 DD000184-06, U50/CCU422345.We would like to thank Renee Clark and the Research Registry Core of the Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at UNC-Chapel Hill (Grant Number HD003110), as well as all the individuals who participated in this research. This work was further supported by the Centers for Disease Control and Prevention (Grant Numbers: U10 DD000184-06, U50/CCU422345). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. CR Adolphs R, 2008, CURR BIOL, V18, P1090, DOI 10.1016/j.cub.2008.06.073 Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022 BAILEY A, 1995, PSYCHOL MED, V25, P63 BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548 Bernier R, 2012, AUTISM RES, V5, P13, DOI 10.1002/aur.226 BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x Browne MW, 2001, MULTIVAR BEHAV RES, V36, P111, DOI 10.1207/S15327906MBR3601_05 CATTELL RB, 1966, MULTIVAR BEHAV RES, V1, P245, DOI 10.1207/s15327906mbr0102_10 Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014 Dawson G, 2007, J AUTISM DEV DISORD, V37, P523, DOI 10.1007/s10803-006-0182-2 DeVellis R. F., 1991, SCALE DEV THEORY APP Fabrigar LR, 1999, PSYCHOL METHODS, V4, P272, DOI 10.1037//1082-989X.4.3.272 Happe F, 2001, J CHILD PSYCHOL PSYC, V42, P299, DOI 10.1111/1469-7610.00723 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 Hughes C, 1997, PSYCHOL MED, V27, P209, DOI 10.1017/S0033291796004308 Hurley RSE, 2007, J AUTISM DEV DISORD, V37, P1679, DOI 10.1007/s10803-006-0299-3 Ingersoll B, 2011, J AUTISM DEV DISORD, V41, P1646, DOI 10.1007/s10803-011-1192-2 LANDA R, 1992, PSYCHOL MED, V22, P245 Losh M, 2007, J CHILD PSYCHOL PSYC, V48, P105, DOI 10.1111/j.1469-7610.2006.01594.x Losh M., 2011, AUTISM SPECTRUM DISO, P457 Losh M, 2008, AM J MED GENET B, V147B, P424, DOI 10.1002/ajmg.b.30612 Losh M, 2009, ARCH GEN PSYCHIAT, V66, P518, DOI 10.1001/archgenpsychiatry.2009.34 Murphy M, 2000, PSYCHOL MED, V30, P1411, DOI 10.1017/S0033291799002949 Nunnally J., 1967, PSYCHOMETRIC METHODS OZONOFF S, 1993, J AUTISM DEV DISORD, V23, P429, DOI 10.1007/BF01046049 Piven J, 1999, AM J PSYCHIAT, V156, P557 PIVEN J, 1994, PSYCHOL MED, V24, P783 Piven J, 1997, AM J MED GENET, V74, P398, DOI 10.1002/(SICI)1096-8628(19970725)74:4<398::AID-AJMG11>3.0.CO;2-D Piven J, 2001, AM J MED GENET, V105, P34, DOI 10.1002/1096-8628(20010108)105:1<34::AID-AJMG1052>3.0.CO;2-D Piven J, 1997, AM J PSYCHIAT, V154, P185 Reznick JS, 2007, J AUTISM DEV DISORD, V37, P1691, DOI 10.1007/s10803-006-0303-y Robinson EB, 2011, ARCH GEN PSYCHIAT, V68, P1113, DOI 10.1001/archgenpsychiatry.2011.119 SANTANGELO SL, 1995, AM J HUM GENET, V57, P89 Scheeren AM, 2008, J AUTISM DEV DISORD, V38, P276, DOI 10.1007/s10803-007-0389-x Sung YJ, 2005, AM J HUM GENET, V76, P68, DOI 10.1086/426951 Szatmari P, 2008, J AUTISM DEV DISORD, V38, P1859, DOI 10.1007/s10803-008-0576-4 Tyrer P, 1988, PERSONALITY DISORDER, P140 NR 37 TC 9 Z9 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2013 VL 6 IS 2 BP 134 EP 143 DI 10.1002/aur.1272 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 133DL UT WOS:000318117500007 PM 23427091 ER PT J AU Brown, MS Singel, D Hepburn, S Rojas, DC AF Brown, Mark S. Singel, Debra Hepburn, Susan Rojas, Donald C. TI Increased Glutamate Concentration in the Auditory Cortex of Persons With Autism and First-Degree Relatives: A 1H-MRS Study SO AUTISM RESEARCH LA English DT Article DE glutamate; n-acetyl-aspartate; creatine; spectroscopy; auditory cortex ID MAGNETIC-RESONANCE-SPECTROSCOPY; SPECTRUM DISORDERS; FUNCTIONING AUTISM; MENTAL-RETARDATION; BRAIN-METABOLITES; ASPERGER-SYNDROME; LOCALIZED PROTON; MR SPECTROSCOPY; CHILDREN; AGE AB Increased glutamate levels have been reported in the hippocampal and frontal regions of persons with autism using proton magnetic resonance spectroscopy (1H-MRS). Although autism spectrum disorders (ASDs) are highly heritable, MRS studies have not included relatives of persons with ASD. We therefore conducted a study to determine if glutamate levels are elevated in people with autism and parents of children with autism. Single-voxel, point-resolved spectroscopy data were acquired at 3T for left and right hemisphere auditory cortical voxels in 13 adults with autism, 15 parents of children with autism, and 15 adult control subjects. The primary measure was glutamate+glutamine (Glx). Additional measures included n-acetyl-aspartate (NAA), choline (Cho), myoinositol (mI), and creatine (Cr). The autism group had significantly higher Glx, NAA, and Cr concentrations than the control subjects. Parents did not differ from control subjects on any measures. No significant differences in Cho or mI levels were seen among groups. No reliable correlations between autism symptom measures, and MRS variables were seen after Bonferroni correction for multiple comparisons. The elevation in Glx in autism is consistent with prior MRS data in the hippocampus and frontal lobe and may suggest increased cortical excitability. Increased NAA and Cr may indicate brain metabolism disturbances in autism. In the current study, we found no reliable evidence of a familial effect for any spectroscopy measure. This may indicate that these metabolites have no heritable component in autism, the presence of a compensatory factor in parents, or sample-specific limitations such as the participation of singleton families. Autism Res 2012, ..:..... (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Brown, Mark S.] Univ Colorado, Dept Radiol, Aurora, CO 80045 USA. [Singel, Debra; Hepburn, Susan; Rojas, Donald C.] Univ Colorado, Dept Psychiat, Aurora, CO 80045 USA. [Brown, Mark S.; Singel, Debra; Rojas, Donald C.] Univ Colorado, Colorado Translat Res Imaging Ctr, Aurora, CO 80045 USA. [Hepburn, Susan] Univ Colorado, JFK Ctr Dev Disabil, Aurora, CO 80045 USA. RP Rojas, DC (reprint author), Univ Colorado, Dept Psychiat, Denver Anschutz Med Campus,13001 E 17th Ave, Aurora, CO 80045 USA. EM don.rojas@ucdenver.edu FU NIH/NIMH [R01 MH082820]; NIH/NCRR Colorado CTSI [UL1 RR025780] FX Grant information: NIH/NIMH grant R01 MH082820 and NIH/NCRR Colorado CTSI grant UL1 RR025780. CR Aoki Y, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2011.65 Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 BAUMAN M, 1985, NEUROLOGY, V35, P866 Bauman ML, 1994, NEUROBIOLOGY AUTISM, P119 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Bejjani A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038786 Bernardi S, 2011, BRAIN RES, V1380, P198, DOI 10.1016/j.brainres.2010.12.057 Blatt GJ, 2001, J AUTISM DEV DISORD, V31, P537, DOI 10.1023/A:1013238809666 Bustillo JR, 2008, NEUROPSYCHOPHARMACOL, V33, P2456, DOI 10.1038/sj.npp.1301631 Chez MG, 2007, J CHILD NEUROL, V22, P574, DOI 10.1177/0883073807302611 Chih B, 2005, SCIENCE, V307, P1324, DOI 10.1126/science.1107470 Chugani DC, 1999, PROG NEURO-PSYCHOPH, V23, P635, DOI 10.1016/S0278-5846(99)00022-6 Clark JB, 1998, DEV NEUROSCI-BASEL, V20, P271, DOI 10.1159/000017321 Coghlan S, 2012, NEUROSCI BIOBEHAV R, V36, P2044, DOI 10.1016/j.neubiorev.2012.07.005 Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014 DeVito TJ, 2007, BIOL PSYCHIAT, V61, P465, DOI 10.1016/j.biopsych.2006.07.022 Dhossche Dirk, 2002, Med Sci Monit, V8, pPR1 Endo T, 2007, BIOL PSYCHIAT, V62, P1030, DOI 10.1016/j.biopsych.2007.05.015 Erickson CA, 2011, J CHILD ADOL PSYCHOP, V21, P565, DOI 10.1089/cap.2011.0034 Fatemi SH, 2011, ANAT REC, V294, P1635, DOI 10.1002/ar.21299 Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0 Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7 Fatemi SH, 2008, PROG NEURO-PSYCHOPH, V32, P911, DOI 10.1016/j.pnpbp.2007.11.004 Friedman SD, 2006, ARCH GEN PSYCHIAT, V63, P786, DOI 10.1001/archpsyc.63.7.786 Gabis L, 2008, J CHILD NEUROL, V23, P766, DOI 10.1177/0883073808315423 Gandal MJ, 2010, BIOL PSYCHIAT, V68, P1100, DOI 10.1016/j.biopsych.2010.09.031 Gurkan CK, 2012, RES AUTISM SPECT DIS, V6, P1311, DOI DOI 10.1016/J.RASD.2012.05.007 Harada M, 2010, J AUTISM DEV DISORD, V41, P447, DOI 10.1007/s10803-010-1065-0 Hardan AY, 2008, PSYCHIAT RES-NEUROIM, V163, P97, DOI 10.1016/j.pscychresns.2007.12.002 Hashimoto T, 1997, J CHILD NEUROL, V12, P91 Hisaoka S, 2001, NEURORADIOLOGY, V43, P496 Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA Hussman JP, 2001, J AUTISM DEV DISORD, V31, P247, DOI 10.1023/A:1010715619091 Jacob S, 2011, PSYCHIAT GENET, V21, P212, DOI 10.1097/YPG.0b013e328341a323 Kaiser LG, 2005, NEUROBIOL AGING, V26, P665, DOI 10.1016/j.neurobiolaging.2004.07.001 Kaymak SU, 2009, PSYCHIAT CLIN NEUROS, V63, P350, DOI 10.1111/j.1440-1819.2009.01951.x Kielinen M, 2004, AUTISM, V8, P49, DOI 10.1177/1362361304040638 Kleinhans NM, 2009, J AUTISM DEV DISORD, V39, P1079, DOI 10.1007/s10803-009-0707-6 Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522 Levitt JG, 2003, BIOL PSYCHIAT, V54, P1355, DOI 10.1016/S0006-3223(03)00688-7 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Losh M, 2008, AM J MED GENET B, V147B, P424, DOI 10.1002/ajmg.b.30612 Murphy DGM, 2002, ARCH GEN PSYCHIAT, V59, P885, DOI 10.1001/archpsyc.59.10.885 O'Brien FM, 2010, PSYCHIAT RES-NEUROIM, V184, P77, DOI 10.1016/j.pscychresns.2010.08.007 Otsuka H, 1999, NEURORADIOLOGY, V41, P517 Page LA, 2006, AM J PSYCHIAT, V163, P2189, DOI 10.1176/appi.ajp.163.12.2189 PROVENCHER SW, 1993, MAGNET RESON MED, V30, P672, DOI 10.1002/mrm.1910300604 Purcell AE, 2001, NEUROLOGY, V57, P1618 RITVO ER, 1986, AM J PSYCHIAT, V143, P862 Rojas DC, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-66 Rojas DC, 1997, AM J PSYCHIAT, V154, P1655 Rojas DC, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-11 Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Sailasuta N, 2008, MAGN RESON IMAGING, V26, P667, DOI 10.1016/j.mri.2007.06.007 Schaefer GB, 2006, GENET MED, V8, P549, DOI 10.1097/01.gim.0000237789.98842.fi Shinohe A, 2006, PROG NEURO-PSYCHOPH, V30, P1472, DOI 10.1016/j.pnpbp.2006.06.013 Soares DP, 2009, CLIN RADIOL, V64, P12, DOI 10.1016/j.crad.2008.07.002 Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 Szulc A, 2011, PHARMACOPSYCHIATRY, V44, P148, DOI 10.1055/s-0031-1279739 Taylor MJ, 2010, J PSYCHOPHARMACOL, V24, P1217, DOI 10.1177/0269881109105679 The Psychological Corporation, 1999, WECHSL ABBR SCAL INT Tuchman R, 2010, BRAIN DEV-JPN, V32, P709, DOI 10.1016/j.braindev.2010.04.008 URENJAK J, 1993, J NEUROSCI, V13, P981 VANDERKNAAP MS, 1990, RADIOLOGY, V176, P509 Vasconcelos MM, 2008, J NEUROIMAGING, V18, P288, DOI 10.1111/j.1552-6569.2007.00200.x Virkud YV, 2009, AM J MED GENET B, V150B, P328, DOI 10.1002/ajmg.b.30810 Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002 Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3 Zeegers M, 2007, J NEURAL TRANSM, V114, P289, DOI 10.1007/s00702-006-0501-y NR 71 TC 11 Z9 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2013 VL 6 IS 1 BP 1 EP 10 DI 10.1002/aur.1260 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 094YB UT WOS:000315300300001 PM 23166003 ER PT J AU Cohen, IL Gardner, JM Karmel, BZ Phan, HTT Kittler, P Gomez, TR Gonzalez, MG Lennon, EM Parab, S Barone, A AF Cohen, Ira L. Gardner, Judith M. Karmel, Bernard Z. Phan, Ha T. T. Kittler, Phyllis Gomez, Tina Rovito Gonzalez, Maripaz G. Lennon, Elizabeth M. Parab, Santosh Barone, Anthony TI Neonatal Brainstem Function and 4-Month Arousal-Modulated Attention Are Jointly Associated With Autism SO AUTISM RESEARCH LA English DT Article DE auditory brainstem response; infancy; attention; arousal; repetitive and ritualistic behaviors; autism spectrum disorder ID AUDITORY-EVOKED-RESPONSES; SPECTRUM DISORDERS; INFANTILE-AUTISM; YOUNG-CHILDREN; PERINATAL RISK; INDICATORS; BEHAVIOR; AMYGDALA; INSULT; MODEL AB The authors evaluated the contribution of initially abnormal neonatal auditory brainstem responses (ABRs) and 4-month arousal-modulated attention visual preference to later autism spectrum disorder (ASD) behaviors in neonatal intensive care unit (NICU) graduates. A longitudinal study design was used to compare NICU graduates with normal ABRs (n=28) to those with initially abnormal ABRs (n=46) that later resolved. At 4 months postterm age, visual preference (measured after feeding) for a random check pattern flashing at 1, 3, or 8Hz and gestational age (GA) served as additional predictors. Outcome measures were PDD Behavior Inventory (PDDBI) scores at 3.4 years (standard deviation=1.2), and developmental quotients (DQ) obtained around the same age with the Griffiths Mental Development Scales (GMDS). Preferences for higher rates of stimulation at 4 months were highly correlated with PDDBI scores (all P-values<0.01) and the GMDS Hearing and Speech DQ, but only in those with initially abnormal ABRs. Effects were strongest for a PDDBI social competence measure most associated with a diagnosis of autism. For those with abnormal ABRs, increases in preference for higher rates of stimulation as infants were linked to nonlinear increases in severity of ASD at 3 years and to an ASD diagnosis. Abnormal ABRs were associated with later reports of repetitive and ritualistic behaviors irrespective of 4-month preference for stimulation. The joint occurrence of initially abnormal neonatal ABRs and preference for more stimulation at 4 months, both indices of early brainstem dysfunction, may be a marker for the development of autism in this cohort. Autism Res 2012, ..:..... (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Cohen, Ira L.; Gomez, Tina Rovito; Gonzalez, Maripaz G.] New York State Inst Basic Res Dev Disabil, Dept Psychol, Staten Isl, NY 10314 USA. [Gardner, Judith M.; Karmel, Bernard Z.; Phan, Ha T. T.; Kittler, Phyllis; Lennon, Elizabeth M.] New York State Inst Basic Res Dev Disabil, Dept Infant Dev, Staten Isl, NY 10314 USA. [Parab, Santosh; Barone, Anthony] Univ Richmond, Med Ctr, Dept Neonatol, Staten Isl, NY USA. RP Cohen, IL (reprint author), New York State Inst Basic Res Dev Disabil, Dept Psychol, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA. EM ira.cohen@opwdd.ny.gov FU NYS; NICHD [PO1-HD047281-04] FX This research was supported by funds from NYS Legislative Grant (Cohen), and NICHD grant #PO1-HD047281-04 (Gardner). CR Amaral DG, 2003, GENES BRAIN BEHAV, V2, P295, DOI 10.1034/j.1601-183X.2003.00043.x Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7 BAUMAN M, 1985, NEUROLOGY, V35, P866 Ben-Yizhak N, 2011, J AUTISM DEV DISORD, V41, P750, DOI 10.1007/s10803-010-1096-6 Bosl W, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-18 Cauda F, 2011, J NEUROL NEUROSUR PS, V82, P1304, DOI 10.1136/jnnp.2010.239111 Cohen I. L., 2005, PDD BEHAV INVENTORY Cohen IL, 2010, J AUTISM DEV DISORD, V40, P246, DOI 10.1007/s10803-009-0863-8 Coleman M., 2012, AUTISMS Di Martino A, 2011, BIOL PSYCHIAT, V69, P847, DOI 10.1016/j.biopsych.2010.10.029 Elsabbagh M, 2009, J CHILD PSYCHOL PSYC, V50, P637, DOI 10.1111/j.1469-7610.2008.02051.x Elsabbagh M, 2012, CURR BIOL, V22, P338, DOI 10.1016/j.cub.2011.12.056 Fatemi SH, 2012, CEREBELLUM, V11, P777, DOI 10.1007/s12311-012-0355-9 Gardner J. M., 1992, DEV PSYCHOL, V25, P821 Gardner J. M., 2003, PERSPECTIVES FUNDAME, V2, P125 GARDNER JM, 1990, DEV PSYCHOL, V26, P563, DOI 10.1037//0012-1649.26.4.563 GARDNER JM, 1995, DEV PSYCHOL, V31, P473, DOI 10.1037//0012-1649.31.3.473 Geva R, 2008, J CHILD PSYCHOL PSYC, V49, P1031, DOI 10.1111/j.1469-7610.2008.01918.x Geva R, 2013, SOC COGN AFFECT NEUR, V8, P158, DOI 10.1093/scan/nsr082 Griffiths R., 1984, ABILITIES YOUNG CHIL HASHIMOTO T, 1991, Tokushima Journal of Experimental Medicine, V38, P15 Howard JS, 2005, RES DEV DISABIL, V26, P359, DOI 10.1016/j.ridd.2004.09.005 Hsieh YL, 1998, PHYSIOL BEHAV, V64, P179, DOI 10.1016/S0031-9384(98)00035-3 Jou RJ, 2009, PSYCHOL MED, V39, P1347, DOI 10.1017/S0033291708004376 Karmel BZ, 1996, DEV PSYCHOBIOL, V29, P463, DOI 10.1002/(SICI)1098-2302(199607)29:5<463::AID-DEV5>3.0.CO;2-M Karmel BZ, 2010, PEDIATRICS, V126, P457, DOI 10.1542/peds.2009-2680 KARMEL BZ, 1988, ELECTROEN CLIN NEURO, V71, P429, DOI 10.1016/0168-5597(88)90047-0 Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326 Kulesza RJ, 2011, BRAIN RES, V1367, P360, DOI 10.1016/j.brainres.2010.10.015 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Maziade M, 2000, ARCH GEN PSYCHIAT, V57, P1077, DOI 10.1001/archpsyc.57.11.1077 Mundy P, 2009, AUTISM RES, V2, P2, DOI 10.1002/aur.61 Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009 Ozonoff S, 2009, J DEV BEHAV PEDIATR, V30, P367 Posner M. I., 1994, INT PERSPECTIVES PSY, P41 RINCOVER A, 1977, J EXP CHILD PSYCHOL, V24, P312, DOI 10.1016/0022-0965(77)90009-1 Rosenhall U, 2003, EAR HEARING, V24, P206, DOI 10.1097/01.AUD.0000069326.11466.7E Roth DAE, 2012, DEV MED CHILD NEUROL, V54, P23, DOI 10.1111/j.1469-8749.2011.04149.x SANDBERG AD, 1993, BRIT J PSYCHOL, V84, P365 Schendel D, 2008, PEDIATRICS, V121, P1155, DOI 10.1542/peds.2007-1049 Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010 StatSoft Inc., 2011, STATISTICA DAT AN SO STEIN L, 1983, J PEDIATR-US, V103, P447, DOI 10.1016/S0022-3476(83)80426-0 Suzuki N, 2004, PEDIATR INT, V46, P255, DOI 10.1111/j.1442-200x.2004.01897.x Tassone F, 2008, J MOL DIAGN, V10, P43, DOI 10.2353/jmoldx.2008.070073 Virues-Ortega J, 2010, CLIN PSYCHOL REV, V30, P387, DOI 10.1016/j.cpr.2010.01.008 Walsh P, 2011, NAT REV NEUROSCI, V12, P603, DOI 10.1038/nrn3113 Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4 Wingate M., 2012, MMWR SURVEILL SUMM, V61, P1 Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447 Zwaigenbaum L, 2007, J AUTISM DEV DISORD, V37, P466, DOI 10.1007/s10803-006-0179-x Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001 NR 53 TC 6 Z9 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2013 VL 6 IS 1 BP 11 EP 22 DI 10.1002/aur.1259 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 094YB UT WOS:000315300300002 PM 23165989 ER PT J AU Nielsen, M Slaughter, V Dissanayake, C AF Nielsen, Mark Slaughter, Virginia Dissanayake, Cheryl TI Object-Directed Imitation in Children With High-Functioning Autism: Testing the Social Motivation Hypothesis SO AUTISM RESEARCH LA English DT Article DE social cognition; overimitation; synchronic imitation; social learning; autism ID MIRROR SELF-RECOGNITION; YOUNG-CHILDREN; OVER-IMITATION; DOWN-SYNDROME; PRETEND PLAY; RECIPROCAL IMITATION; JOINT ATTENTION; HOMO-SAPIENS; 2ND YEAR; TOOL USE AB Children with autism show clear deficits in copying others' bodily oriented actions whereas their capacity for replicating others' object-directed actions appears relatively spared. One explanation is that unlike bodily oriented actions, object-directed actions have tangible, functional outcomes and hence rely far less on social motivations for their production. To investigate this, we compared the performance of a group of children with high-functioning autism (HFA) and a group of typically developing (TD) children on two distinct object-directed tasks that are considered highly social: overimitation and synchronic imitation. Our findings were surprising. The HFA children copied all of a modeling adult's actions, including those that had no function or purpose (i.e. they overimitated), and they entered into extended bouts repeating an arbitrary action along with the adult who had a similar object to play with (i.e. they engaged in synchronic imitation). Moreover, they did so at rates indistinguishable from the TD children. This work demonstrates that the capacity and propensity for overimitation and synchronic imitation are intact in children with HFA, and questions whether socially based imitation should be considered an autism-specific deficit. Autism Res 2012, ..:..... (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Nielsen, Mark; Slaughter, Virginia] Univ Queensland, Sch Psychol, Early Cognit Dev Ctr, Brisbane, Qld 4072, Australia. [Dissanayake, Cheryl] La Trobe Univ, Sch Psychol Sci, Olga Tennison Autism Res Ctr, Bundoora, Vic 3086, Australia. RP Nielsen, M (reprint author), Univ Queensland, Sch Psychol, Brisbane, Qld 4072, Australia. EM nielsen@psy.uq.edu.au FU Apex Foundation Trust; Australian Research Council [DP 110100602] FX Funding: An Apex Foundation Trust for Autism Grant to Mark Nielsen and Virginia Slaughter, and an Australian Research Council Discovery Project Grant (DP 110100602) to Mark Nielsen supported this research. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Asendorpf JB, 1996, DEV PSYCHOL, V32, P313, DOI 10.1037/0012-1649.32.2.313 Bauminger N, 2003, J AUTISM DEV DISORD, V33, P489, DOI 10.1023/A:1025827427901 Bauminger N, 2000, CHILD DEV, V71, P447, DOI 10.1111/1467-8624.00156 Brown J. D., 1998, INTERSUBJECTIVE COMM, P260 Carpenter M., 2010, WILEY BLACKWELL HDB, V2, P106, DOI 10.1002/9781444325485.ch4 Chartrand TL, 1999, J PERS SOC PSYCHOL, V76, P893, DOI 10.1037//0022-3514.76.6.893 Chevallier C, 2012, TRENDS COGN SCI, V16, P231, DOI 10.1016/j.tics.2012.02.007 Chevallier C, 2012, J AUTISM DEV DISORD, V42, P1504, DOI 10.1007/s10803-011-1364-0 Dijksterhuis A., 2005, PERSPECTIVES IMITATI, V2, P207 DiYanni C, 2011, J EXP CHILD PSYCHOL, V110, P575, DOI 10.1016/j.jecp.2011.06.002 ECKERMAN CO, 1989, DEV PSYCHOL, V25, P794, DOI 10.1037/0012-1649.25.5.794 ECKERMAN CO, 1989, CHILD DEV, V60, P440, DOI 10.2307/1130988 Frith U., 2003, AUTISM EXPLAINING EN Garcia-Perez RM, 2007, J AUTISM DEV DISORD, V37, P1310, DOI 10.1007/s10803-006-0276-x Griffin R, 2002, DEVELOPMENTAL SCI, V5, P30, DOI 10.1111/1467-7687.00202 Hayne H, 2003, CHILD DEV, V74, P1615, DOI 10.1046/j.1467-8624.2003.00627.x Heyes C, 2012, J COMP PSYCHOL, V126, P193, DOI 10.1037/a0025180 Hobson JA, 2007, DEV PSYCHOPATHOL, V19, P411, DOI 10.1017/S0954579407070204 Hobson R. P., 2004, CRADLE THOUGHT EXPLO HOBSON RP, 1993, PHILOS PSYCHOL, V6, P227, DOI 10.1080/09515089308573090 Hobson RP, 2008, J EXP CHILD PSYCHOL, V101, P170, DOI 10.1016/j.jecp.2008.04.007 Hobson RP, 2006, IMITATION SOCIAL MIN, P198 Hobson RP, 1999, J CHILD PSYCHOL PSYC, V40, P649, DOI 10.1111/1469-7610.00481 Horner V, 2005, ANIM COGN, V8, P164, DOI 10.1007/s10071-004-0239-6 Ingersoll B, 2006, J AUTISM DEV DISORD, V36, P487, DOI 10.1007/s10803-006-0089-y Ingersoll B, 2003, J AUTISM DEV DISORD, V33, P673, DOI 10.1023/B:JADD.0000006003.26667.f8 Kenward B, 2011, P ROY SOC B-BIOL SCI, V278, P1239, DOI 10.1098/rspb.2010.1399 Lakin JL, 2003, PSYCHOL SCI, V14, P334, DOI 10.1111/1467-9280.14481 Lakin JL, 2003, J NONVERBAL BEHAV, V27, P145, DOI 10.1023/A:1025389814290 Lyons DE, 2007, P NATL ACAD SCI USA, V104, P19751, DOI 10.1073/pnas.0704452104 Lyons DE, 2011, PHILOS T R SOC B, V366, P1158, DOI 10.1098/rstb.2010.0335 McGuigan N, 2011, BRIT J PSYCHOL, V102, P1, DOI 10.1348/000712610X493115 Meltzoff AN, 2007, DEVELOPMENTAL SCI, V10, P126, DOI 10.1111/j.1467-7687.2007.00574.x MELTZOFF AN, 1988, DEV PSYCHOL, V24, P470, DOI 10.1037//0012-1649.24.4.470 Mundy PC, 2007, RES PRACT PERS SEV D, V32, P124 Nadel J, 2011, AUTISM, V15, P421, DOI 10.1177/1362361310386508 Nadel J., 2002, IMITATIVE MIND DEV E, P63 Nadel J., 1999, IMITATION INFANCY, P209 Nadel J, 1993, NEW PERSPECTIVES EAR, P139 NADELBRULFERT J, 1982, INT J BEHAV DEV, V5, P95 NAGELL K, 1993, J COMP PSYCHOL, V107, P174, DOI 10.1037/0735-7036.107.2.174 Nielsen M, 2010, AUST J PSYCHOL, V62, P67, DOI 10.1080/00049530902758613 Nielsen M, 2006, DEV PSYCHOL, V42, P555, DOI 10.1037/0012-1649.42.3.555 Nielsen M, 2012, J COMP PSYCHOL, V126, P170, DOI 10.1037/a0025168 Nielsen M, 2004, INFANT BEHAV DEV, V27, P342, DOI 10.1016/j.infbeh.2003.12.006 Nielsen M, 2008, BEHAV BRAIN SCI, V31, P33, DOI 10.1017/S0140525X0700324X Nielsen M, 2008, DEVELOPMENTAL SCI, V11, P722, DOI 10.1111/j.1467-7687.2008.00722.x Nielsen M, 2011, DEV PSYCHOL, V47, P1050, DOI 10.1037/a0023866 Nielsen M., 2006, IMITATION SOCIAL MIN, P138 Nielsen M, 2010, PSYCHOL SCI, V21, P729, DOI 10.1177/0956797610368808 Nielsen M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034066 Over H, 2012, J COMP PSYCHOL, V126, P182, DOI 10.1037/a0024555 RAST M, 1995, DEV PSYCHOPATHOL, V7, P393 Rogers S. J., 1999, IMITATION INFANCY, P253 Rogers S. J., 2006, IMITATION SOCIAL MIN, P277 Rogers S. J., 1991, DEV PSYCHOPATHOL, V107, P147 Rogers SJ, 2010, DEV PSYCHOPATHOL, V22, P71, DOI 10.1017/S0954579409990277 Rutter M., 2003, SOCIAL COMMUNICATION Sevlever M, 2010, RES DEV DISABIL, V31, P976, DOI 10.1016/j.ridd.2010.04.014 SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037//0033-2909.86.2.420 Slaughter V, 2008, INFANCY, V13, P185, DOI 10.1080/15250000701795721 Southgate V, 2008, TRENDS COGN SCI, V12, P225, DOI 10.1016/j.tics.2008.03.005 Sutton S. K., 2004, J CHILD PSYCHOL PSYC, V45, P1 Tennie C, 2009, PHILOS T R SOC B, V364, P2405, DOI 10.1098/rstb.2009.0052 Thorpe WH., 1961, BIRD SONG BIOL VOCAL UZGIRIS IC, 1981, INT J BEHAV DEV, V4, P1 Vanvuchelen M, 2011, RES AUTISM SPECT DIS, V5, P89, DOI 10.1016/j.rasd.2010.07.010 Wechsler D., 2002, WECHSLER PRESCHOOL P, V3rd Whiten A., DEV SOCIAL IN PRESS Whiten A, 2009, PHILOS T R SOC B, V364, P2417, DOI 10.1098/rstb.2009.0069 Wiggins L. D., 2007, FOCUS AUTISM OTHER D, V22, P33, DOI [10.1177/10883576070220010401, DOI 10.1177/10883576070220010401] Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8 Wright I, 2006, BRIT J DEV PSYCHOL, V24, P429, DOI 10.1348/026151005X51257 Zentall TR, 2012, J COMP PSYCHOL, V126, P114, DOI 10.1037/a0025381 NR 76 TC 8 Z9 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2013 VL 6 IS 1 BP 23 EP 32 DI 10.1002/aur.1261 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 094YB UT WOS:000315300300003 PM 23166017 ER PT J AU Gotham, K Bishop, SL Hus, V Huerta, M Lund, S Buja, A Krieger, A Lord, C AF Gotham, Katherine Bishop, Somer L. Hus, Vanessa Huerta, Marisela Lund, Sabata Buja, Andreas Krieger, Abba Lord, Catherine TI Exploring the Relationship Between Anxiety and Insistence on Sameness in Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; anxiety; insistence on sameness; Simons Simplex Collection; Child Behavior Checklist 618 (CBCL); Autism Diagnostic Interview-Revised (ADI-R) ID COMORBID PSYCHIATRIC-DISORDERS; REPETITIVE BEHAVIORS; SYMPTOM SEVERITY; CHILDREN; ASSOCIATION; AMYGDALA; PHENOTYPE; ADHD AB Elevated anxiety symptoms are one of the most common forms of psychopathology to co-occur with autism spectrum disorders (ASDs). The purpose of this study was to explore the association between anxiety and ASD symptoms, particularly the degree to which the relationship is explained by insistence on sameness (IS) behaviors and/or cognitive ability. The sample included 1429 individuals aged 5:818:0 years who participated in the Simons Simplex Collection, a genetic consortium study of ASD. Child Behavior Checklist Anxiety Problems T-scores and Autism Diagnostic Interview-Revised IS item raw totals were treated as both categorical and continuous measures of anxiety and IS, respectively. Chronological age, verbal intelligence quotient (IQ), and a variety of ASD phenotype-related and other behavioral variables were assessed for potential association with anxiety and IS. Anxiety and IS continuous variables were minimally, although significantly, associated with each other and with chronological age and verbal IQ. Neither anxiety nor IS was associated with other core autism diagnostic scores. Anxiety was associated with a variety of other psychiatric and behavioral symptoms in ASD, including irritability, attention problems, and aggression, while IS was not. Anxiety and IS appear to function as distinct constructs, each with a wide range of expression in children with ASD across age and IQ levels. Thus, both variables could be of use in ASD behavioral research or in dimensional approaches to genetic exploration. Unlike IS, however, anxiety is related to non-ASD-specific behavioral symptoms. Autism Res 2012, ..: ..... (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Gotham, Katherine] Vanderbilt Kennedy Ctr, Nashville, TN USA. [Bishop, Somer L.; Huerta, Marisela; Lord, Catherine] New York Presbyterian Hosp, Weill Cornell Med Coll, Ctr Autism & Developing Brain, White Plains, NY USA. [Hus, Vanessa; Lund, Sabata] Univ Michigan, Dept Psychol, Ann Arbor, MI USA. [Buja, Andreas; Krieger, Abba] Univ Penn, Wharton Sch, Philadelphia, PA 19104 USA. RP Gotham, K (reprint author), 1006 Caldwell Lane, Nashville, TN 37204 USA. EM katherine.gotham@vanderbilt.edu FU Simons Foundation (SFARI); National Institutes of Health [T32-MH18921, P30HD15052, R01MH081873-01A1, RC1MH089721, R01HD065277] FX This work was supported by:Grant Sponsor: The Simons Foundation (SFARI); Grant Number: Not Applicable (Grants to authors K. G., A. B., and A. K.).Grant Sponsor: National Institutes of Health; Grant Numbers: T32-MH18921; P30HD15052, R01MH081873-01A1, and RC1MH089721 to C.L.; R01HD065277 to S.B. CR Achenbach TM, 2001, MANUAL ASEBA SCH AGE AMAN MG, 1985, AM J MENT DEF, V89, P485 Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005 Amaral DG, 2003, GENES BRAIN BEHAV, V2, P295, DOI 10.1034/j.1601-183X.2003.00043.x Anholt GE, 2010, J AUTISM DEV DISORD, V40, P580, DOI 10.1007/s10803-009-0922-1 [Anonymous], SPSS WIND REL 17 0 1 Balemans MCM, 2010, BEHAV BRAIN RES, V208, P47, DOI 10.1016/j.bbr.2009.11.008 Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7 Benno R, 2009, BEHAV BRAIN RES, V197, P462, DOI 10.1016/j.bbr.2008.09.041 Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x Bishop SL, 2013, J AUTISM DEV DISORD, V43, P1287, DOI 10.1007/s10803-012-1671-0 Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855 Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004 Cannon DS, 2010, MOL AUT, V1, P1 Constantino JN, 2005, SOCIAL RESPONSIVENES Cuccaro ML, 2003, CHILD PSYCHIAT HUM D, V34, P3, DOI 10.1023/A:1025321707947 DeLong R. G., 1988, J AUTISM DEV DISORD, V18, P593 Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006 Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1710, DOI 10.1007/s10803-008-0556-8 Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Green SA, 2010, J AUTISM DEV DISORD, V40, P1495, DOI 10.1007/s10803-010-1007-x Hallett V, 2009, J AM ACAD CHILD PSY, V48, P618, DOI 10.1097/CHI.0b013e31819f7116 Hanson E, 2010, J DEV BEHAV PEDIATR, V31, P649, DOI 10.1097/DBP.0b013e3181ea50ed Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806 Hus V, 2007, BIOL PSYCHIAT, V61, P438, DOI 10.1016/j.biopsych.2006.08.044 Joosten AV, 2009, J AUTISM DEV DISORD, V39, P521, DOI 10.1007/s10803-008-0654-7 Joshi G, 2010, J AUTISM DEV DISORD, V40, P1361, DOI 10.1007/s10803-010-0996-9 Kamp-Becker I, 2009, J AUTISM DEV DISORD, V39, P557, DOI 10.1007/s10803-008-0656-5 Kanne SM, 2009, J AUTISM DEV DISORD, V39, P856, DOI 10.1007/s10803-009-0694-7 Kanner L, 1943, NERV CHILD, V2, P217 Lesch KP, 1998, BIOL PSYCHIAT, V44, P179, DOI 10.1016/S0006-3223(98)00121-8 Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Pandolfi V, 2009, J AUTISM DEV DISORD, V39, P986, DOI 10.1007/s10803-009-0716-5 Piven J, 1999, AM J PSYCHIAT, V156, P557 Rutter M., 2003, AUTISM DIAGNOSTIC IN Sasson NJ, 2011, J AUTISM DEV DISORD, V41, P242, DOI 10.1007/s10803-010-1038-3 SILVERMAN WK, 1991, J CLIN CHILD PSYCHOL, V20, P162, DOI 10.1207/s15374424jccp2002_7 SMALLEY SL, 1995, AM J MED GENET, V60, P19, DOI 10.1002/ajmg.1320600105 Sparrow SS, 2005, VINELAND ADAPTIVE BE Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9 Sweeten TL, 2002, PHARMACOL BIOCHEM BE, V71, P449, DOI 10.1016/S0091-3057(01)00697-9 Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x Takayanagi Y, 2010, BIOCHEM BIOPH RES CO, V396, P703, DOI 10.1016/j.bbrc.2010.04.165 Witwer AN, 2010, J DEV PHYS DISABIL, V22, P367, DOI 10.1007/s10882-010-9194-0 Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x NR 47 TC 13 Z9 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2013 VL 6 IS 1 BP 33 EP 41 DI 10.1002/aur.1263 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 094YB UT WOS:000315300300004 PM 23258569 ER PT J AU Peters, SU Hundley, RJ Wilson, AK Warren, Z Vehorn, A Carvalho, CMB Lupski, JR Ramocki, MB AF Peters, Sarika U. Hundley, Rachel J. Wilson, Amy K. Warren, Zachary Vehorn, Alison Carvalho, Claudia M. B. Lupski, James R. Ramocki, Melissa B. TI The Behavioral Phenotype in MECP2 Duplication Syndrome: A Comparison With Idiopathic Autism SO AUTISM RESEARCH LA English DT Article DE autism; MECP2; genetics; phenotype; social affect; overexpression ID DIAGNOSTIC-OBSERVATION-SCHEDULE; SEVERE MENTAL-RETARDATION; SPECTRUM DISORDERS; RETT-SYNDROME; REVISED ALGORITHMS; REARRANGEMENTS; REGION; XQ28; IDENTIFICATION; ASSOCIATION AB Alterations in the X-linked gene MECP2 encoding the methyl-CpG-binding protein 2 have been linked to autism spectrum disorders (ASDs). Most recently, data suggest that overexpression of MECP2 may be related to ASD. To better characterize the relevance of MECP2 overexpression to ASD-related behaviors, we compared the core symptoms of ASD in MECP2 duplication syndrome to nonverbal mental age-matched boys with idiopathic ASD. Within the MECP2 duplication group, we further delineated aspects of the behavioral phenotype and also examined how duplication size and gene content corresponded to clinical severity. We compared ten males with MECP2 duplication syndrome (ages 310) with a chronological and mental age-matched sample of nine nonverbal males with idiopathic ASD. Our results indicate that boys with MECP2 duplication syndrome share the core behavioral features of ASD (e.g. social affect, restricted/repetitive behaviors). Direct comparisons of ASD profiles revealed that a majority of boys with MECP2 duplication syndrome are similar to idiopathic ASD; they have impairments in social affect (albeit to a lesser degree than idiopathic ASD) and similar severity in restricted/repetitive behaviors. Nonverbal mental age did not correlate with severity of social impairment or repetitive behaviors. Within the MECP2 duplication group, breakpoint size does not predict differences in clinical severity. In addition to social withdrawal and stereotyped behaviors, we also found that hyposensitivity to pain/temperature are part of the behavioral phenotype of MECP2 duplication syndrome. Our results illustrate that overexpression/increased dosage of MECP2 is related to core features of ASD. Autism Res 2012, ..: ..... (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Peters, Sarika U.; Hundley, Rachel J.; Warren, Zachary] Vanderbilt Univ, Dept Pediat, Nashville, TN USA. [Peters, Sarika U.; Hundley, Rachel J.; Warren, Zachary] Vanderbilt Univ, Dept Psychiat, Nashville, TN USA. [Peters, Sarika U.; Hundley, Rachel J.; Wilson, Amy K.; Warren, Zachary; Vehorn, Alison] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN USA. [Carvalho, Claudia M. B.; Lupski, James R.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA. [Ramocki, Melissa B.] Baylor Coll Med, Dept Pediat, Sect Pediat Neurol & Dev Neurosci, Houston, TX 77030 USA. RP Peters, SU (reprint author), Vanderbilt Kennedy Ctr, PMB 74,230 Appleton Pl, Nashville, TN 37203 USA. EM sarika.u.peters@vanderbilt.edu FU Vanderbilt Kennedy Center [5P30HD015052-30]; NINDS [5K08NS062711] FX Funding for this project has been provided by a Vanderbilt Kennedy Center Hobbs Discovery Grant (to S.U.P.), by 5P30HD015052-30 (to Elisabeth Dykens PI), and by NINDS grant 5K08NS062711 (to M.B.R.). We also wish to thank the individuals and families who so graciously participated in this study. CR Ariani F, 2004, HUM MUTAT, V24, P172, DOI 10.1002/humu.20065 Bishop SL, 2011, AJIDD-AM J INTELLECT, V116, P331, DOI 10.1352/1944-7558-116.5.331 Carney RM, 2003, PEDIATR NEUROL, V28, P205, DOI 10.1016/S0887-8994(02)00624-0 Carvalho CMB, 2009, HUM MOL GENET, V18, P2188, DOI 10.1093/hmg/ddp151 Carvalho CMB, 2011, NAT GENET, V43, P1074, DOI 10.1038/ng.944 Cobb S, 2010, BIOCHEM SOC T, V38, P498, DOI 10.1042/BST0380498 Coury D, 2009, CURR OPIN PEDIATR, V21, P828, DOI 10.1097/MOP.0b013e328331eaaa Coutinho AM, 2007, AM J MED GENET B, V144B, P475, DOI 10.1002/ajmg.b.30490 del Gaudio D, 2006, GENET MED, V8, P784, DOI 10.1097/01.gim.0000250502.28516.3c Dolen G, 2010, PHARMACOL THERAPEUT, V127, P78, DOI 10.1016/j.pharmthera.2010.02.008 Downs J, 2010, AM J MED GENET A, V152A, P1197, DOI 10.1002/ajmg.a.33314 Foss-Feig JH, 2012, RES AUTISM SPECT DIS, V6, P337, DOI 10.1016/j.rasd.2011.06.007 Friez MJ, 2006, PEDIATRICS, V118, pE1687, DOI 10.1524/peds.2006-0395 Geranton SM, 2008, MOL PAIN, V4, DOI 10.1186/1744-8069-4-35 Geschwind DH, 2011, TRENDS COGN SCI, V15, P409, DOI 10.1016/j.tics.2011.07.003 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Gotham K, 2008, J AM ACAD CHILD PSY, V47, P642, DOI 10.1097/CHI.0b013e31816bffb7 Grasshoff U, 2011, EUR J HUM GENET, V19, P507, DOI 10.1038/ejhg.2010.226 Kuwano Y, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024723 Liu J, 2006, HUM MOL GENET, V15, P1769, DOI 10.1093/hmg/ddl099 Loat CS, 2008, GENES BRAIN BEHAV, V7, P754, DOI 10.1111/j.1601-183X.2008.00414.x Lord C, 2012, ARCH GEN PSYCHIAT, V69, P306, DOI 10.1001/archgenpsychiatry.2011.148 Lord C, 2009, BRIT J HOSP MED, V70, P132 Lugtenberg D, 2009, EUR J HUM GENET, V17, P444, DOI 10.1038/ejhg.2008.208 Meins M, 2005, J MED GENET, V42, DOI 10.1136/jmg.2004.023804 Piton A, 2011, MOL PSYCHIATR, V16, P867, DOI 10.1038/mp.2010.54 Ramocki MB, 2008, NATURE, V455, P912, DOI 10.1038/nature07457 Ramocki MB, 2010, AM J MED GENET A, V152A, P1079, DOI 10.1002/ajmg.a.33184 Ramocki MB, 2009, ANN NEUROL, V66, P771, DOI 10.1002/ana.21715 Samaco RC, 2008, HUM MOL GENET, V17, P1718, DOI 10.1093/hmg/ddn062 Samaco RC, 2009, P NATL ACAD SCI USA, V106, P21966, DOI 10.1073/pnas.0912257106 Samaco RC, 2012, NAT GENET, V44, P206, DOI 10.1038/ng.1066 Sanders SJ, 2011, NEURON, V70, P863, DOI 10.1016/j.neuron.2011.05.002 Shibayama A, 2004, AM J MED GENET B, V128B, P50, DOI 10.1002/ajmg.b.30016 State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924 Van Esch H, 2012, MOL SYNDROMOL, V2, P128, DOI DOI 10.1159/000329580 Van Esch H, 2005, AM J HUM GENET, V77, P442, DOI 10.1086/444549 Veenstra-VanderWeele J, 2012, NEUROPSYCHOPHARMACOL, V37, P196, DOI 10.1038/npp.2011.185 NR 38 TC 11 Z9 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2013 VL 6 IS 1 BP 42 EP 50 DI 10.1002/aur.1262 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 094YB UT WOS:000315300300005 PM 23169761 ER PT J AU Klein, S Sharifi-Hannauer, P Martinez-Agosto, JA AF Klein, Steven Sharifi-Hannauer, Pantea Martinez-Agosto, Julian A. TI Macrocephaly as a Clinical Indicator of Genetic Subtypes in Autism SO AUTISM RESEARCH LA English DT Article DE autism; macrocephaly; PTEN; overgrowth; hypotonia ID SPECTRUM DISORDERS; AFFECTIVE CONTACT; PTEN MUTATIONS; RETARDATION; OVERGROWTH; ABNORMALITIES; DISTURBANCES; INDIVIDUALS AB An association between autism and macrocephaly has been previously described. A subset of cases with extreme macrocephaly (>3 standard deviation [SD], 99.7th percentile) have been correlated to mutations in the gene phosphatase and tensin homolog (PTEN). However, the phenotypic and genetic characterization of the remaining cases remains unclear. We report the phenotypic classification and genetic testing evaluation of a cohort of 33 patients with autism and macrocephaly. Within our cohort, we confirm the association of PTEN mutations and extreme macrocephaly (>3 SD, 99.7th percentile) and identify mutations in 22% of cases, including three novel PTEN mutations. In addition, we define three phenotypic subgroups: (a) those cases associated with somatic overgrowth, (b) those with disproportionate macrocephaly, and (c) those with relative macrocephaly. We have devised a novel way to segregate patients into these subgroups that will aide in the stratification of autism macrocephaly cases. Within these subgroups, we further expand the genetic etiologies for autism cases with macrocephaly by describing two novel suspected pathogenic copy number variants located at 6q23.2 and 10q24.32. These findings demonstrate the phenotypic heterogeneity of autism cases associated with macrocephaly and their genetic etiologies. The clinical yield from PTEN mutation analysis is 22% and 9% from chromosomal microarray (CMA) testing within this cohort. The identification of three distinct phenotypic subgroups within macrocephaly autism patients may allow for the identification of their respective distinct genetic etiologies that to date have remained elusive. Autism Res 2013, 51-56 (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Klein, Steven; Martinez-Agosto, Julian A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA. [Sharifi-Hannauer, Pantea] Univ Calif Los Angeles, David Geffen Sch Med, Div Pediat Neurol, Los Angeles, CA 90095 USA. [Martinez-Agosto, Julian A.] Univ Calif Los Angeles, David Geffen Sch Med, Div Med Genet, Dept Pediat, Los Angeles, CA 90095 USA. RP Martinez-Agosto, JA (reprint author), Gonda Res Ctr, 695 Charles E Young Dr S,Room 4554B, Los Angeles, CA 90095 USA. EM julianmartinez@mednet.ucla.edu FU UCLA [NIH T32GM008042]; American College of Medical Genetics; March of Dimes Foundation [6-324]; Today's and Tomorrow's Children Fund; [NHGRI T32HG002536] FX We would like to thank the patients and their families for their participation in this work. SK performed the retrospective chart review, compiled and analyzed the data, and wrote the manuscript. JAMA performed the clinical evaluation and genetic testing of all cases, performed the analysis, and wrote the manuscript. SK is a trainee in the UCLA-Caltech Medical Scientist Training Program (NIH T32GM008042) and was additionally supported by a Summer Scholars Grant from the American College of Medical Genetics and NHGRI T32HG002536. This work was supported in part by Research Grant no. 6-324 from the March of Dimes Foundation and the Today's and Tomorrow's Children Fund. CR Bruining H, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010887 Brunetti-Pierri N, 2008, NAT GENET, V40, P1466, DOI 10.1038/ng.279 Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646 Buxbaum JD, 2007, AM J MED GENET B, V144B, P484, DOI 10.1002/ajmg.b.30493 Cohen MM, 2003, AM J MED GENET C, V117C, P49, DOI 10.1002/ajmg.c.10013 Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337 Courchesne E, 2004, MENT RETARD DEV D R, V10, P106, DOI 10.1002/mrdd.20020 Etherton MR, 2011, EMBO J, V30, P2908, DOI 10.1038/emboj.2011.182 Giannandrea M, 2010, AM J HUM GENET, V86, P185, DOI 10.1016/j.ajhg.2010.01.011 Herman GE, 2007, AM J MED GENET A, V143A, P589, DOI 10.1002/ajmg.a.31619 Herman GE, 2007, GENET MED, V9, P268, DOI 10.1097/GIM.0b013e31804d683b Hobert JA, 2009, GENET MED, V11, P687, DOI 10.1097/GIM.0b013e3181ac9aea Hu VW, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019067 Iurov I Iu, 2010, Genetika, V46, P1348 Jaillard S, 2010, EUR J MED GENET, V53, P66, DOI 10.1016/j.ejmg.2009.10.002 Kanner L, 1943, NERV CHILD, V2, P217 KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100 Kent L, 2008, AM J MED GENET B, V147B, P1295, DOI 10.1002/ajmg.b.30729 Lopez-Hernandez T, 2011, AM J HUM GENET, V88, P422, DOI 10.1016/j.ajhg.2011.02.009 Manning M, 2010, GENET MED, V12, P742, DOI 10.1097/GIM.0b013e3181f8baad McBride KL, 2010, AUTISM RES, V3, P137, DOI 10.1002/aur.132 Mester JL, 2011, EUR J HUM GENET, V19, P763, DOI 10.1038/ejhg.2011.20 Moreno-De-Luca D, 2010, AM J HUM GENET, V87, P618, DOI 10.1016/j.ajhg.2010.10.004 Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472 Naqvi S, 2000, AM J MED GENET, V94, P149, DOI 10.1002/1096-8628(20000911)94:2<149::AID-AJMG7>3.0.CO;2-# Rollins JD, 2010, J PEDIATR-US, V156, P907, DOI 10.1016/j.jpeds.2010.01.009 Rosenfeld JA, 2010, GENET MED, V12, P694, DOI 10.1097/GIM.0b013e3181f0c5f3 Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684 Spence Sarah J, 2004, Semin Pediatr Neurol, V11, P196, DOI 10.1016/j.spen.2004.07.003 Vorstman J A S, 2006, Mol Psychiatry, V11, P18, DOI 10.1038/sj.mp.4001781 Whitehouse AJO, 2011, GENES BRAIN BEHAV, V10, P451, DOI 10.1111/j.1601-183X.2011.00684.x NR 31 TC 11 Z9 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2013 VL 6 IS 1 BP 51 EP 56 DI 10.1002/aur.1266 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 094YB UT WOS:000315300300006 PM 23361946 ER PT J AU Windham, GC Sumner, A Li, SX Anderson, M Katz, E Croen, LA Grether, JK AF Windham, Gayle C. Sumner, Austin Li, Sherian X. Anderson, Meredith Katz, Elizabeth Croen, Lisa A. Grether, Judith K. TI Use of Birth Certificates to Examine Maternal Occupational Exposures and Autism Spectrum Disorders in Offspring SO AUTISM RESEARCH LA English DT Article DE autism; exposures; occupation; chemicals ID HAZARDOUS AIR-POLLUTANTS; RESIDENTIAL PROXIMITY; ENVIRONMENTAL-FACTORS; CALIFORNIA; PREGNANCY; OUTCOMES; REGRESSION; POLLUTION; AGE AB The continuing rise in the prevalence of autism spectrum disorders has led to heightened interest in the role of nongenetic factors, including exogenous exposures, but little research has been conducted. To explore a possible role in autism etiology, we used data available from our prior studies to examine potential occupational exposures, as these may occur at higher levels than environmental exposures. Parental occupation was obtained from birth certificates for 284 children with autism and 659 controls, born in 1994 in the San Francisco Bay Area. Self-reported occupation and industry were coded into eight exposure/chemical groups based on potential neurotoxicity or reprotoxicity by a board-certified physician in occupational medicine and an industrial hygienist blinded to case-control status. Mothers of autistic children were twice as likely to work in occupations considered exposed (14.4%) as mothers of controls (7.2%) (adjusted odds ratio [AOR] 2.3 [95% confidence interval {CI} 1.34.2]). The exposure categories of the greatest frequency among case mothers were exhaust and combustion products (AOR=12.0 [95% CI 1.4104.6]) and disinfectants (AOR=4.0 [95% CI 1.412.0]). Paternal occupational exposure was not associated with autism, potentially consistent with a direct in-utero exposure effect. There are several limitations of this hypothesis-generating study, including lack of detail on workplace and job duties, leading to possible misclassification and low proportion exposed. However, this misclassification would not be biased by case-control status and is unlikely to explain the associations we did find, suggesting that further research on exogenous exposures may yield useful etiologic clues. Autism Res 2013, ..: ..... (c) 2013 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Windham, Gayle C.; Sumner, Austin; Anderson, Meredith; Katz, Elizabeth; Grether, Judith K.] Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, Richmond, CA 94804 USA. [Li, Sherian X.; Croen, Lisa A.] Kaiser Permanente, Kaiser Fdn Res Inst, Div Res, Oakland, CA USA. RP Windham, GC (reprint author), Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, 850 Marina Bay Pkwy,Bldg P, Richmond, CA 94804 USA. EM gayle.windham@cdph.ca.gov FU Autism Speaks [1758]; Centers for Disease Control and Prevention for the original Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) FX This study was supported in part by a grant from Autism Speaks, #1758. We also acknowledge the support of the Centers for Disease Control and Prevention for the original Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) surveillance project, the efforts of the CADDRE staff in collecting the data, and the cooperation of the Departments of Developmental Services and Vital Records in providing data. Discussions with staff members at the Occupational Health Branch of the CA Department of Public Health were also helpful. There are no author conflicts of interest to declare. CR Ashwood P, 2004, AUTOIMMUN REV, V3, P557, DOI 10.1016/j.autrev.2004.07.036 Autism and Developmental Disabilities Monitoring Network Surveillance Year 2006 Principal Investigators; Centers for Disease Control and Prevention (CDC), 2009, MMWR SURVEILLANCE SU, V58, P1 Brauer M, 2008, ENVIRON HEALTH PERSP, V116, P680, DOI 10.1289/ehp.10952 Campbell A, 2005, NEUROTOXICOLOGY, V26, P133, DOI 10.1016/j.neuro.2004.08.003 Coleman M., 1976, AUTISTIC SYNDROMES, P11 de Medeiros APP, 2009, ENVIRON HEALTH PERSP, V117, P127, DOI 10.1289/ehp.11679 Engel SM, 2010, ENVIRON HEALTH PERSP, V118, P565, DOI 10.1289/ehp.0901470 EPA U.S., 2002, EPA600890057F Felicetti T, 1981, MILIEU THERAPY, V1, P13 Green RS, 2009, ENVIRON HEALTH PERSP, V117, P1939, DOI 10.1289/ehp.0900943 Guxens M., 2012, SWISS MED WKLY, V141 Hallmayer J, 2011, ARCH GEN PSYCHIAT, V68, P1095, DOI 10.1001/archgenpsychiatry.2011.76 Herbstman JB, 2010, ENVIRON HEALTH PERSP, V118, P712, DOI 10.1289/ehp.0901340 Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15 HIRJI KF, 1987, J AM STAT ASSOC, V82, P1110, DOI 10.2307/2289388 Jones KL, 2011, BIRTH DEFECTS RES C, V93, P3, DOI 10.1002/bdrc.20200 Kalkbrenner AE, 2010, EPIDEMIOLOGY, V21, P631, DOI 10.1097/EDE.0b013e3181e65d76 Landrigan PJ, 2010, CURR OPIN PEDIATR, V22, P219, DOI 10.1097/MOP.0b013e328336eb9a Laslo-Baker D, 2004, ARCH PEDIAT ADOL MED, V158, P956, DOI 10.1001/archpedi.158.10.956 Lawler CP, 2008, ENVIRON HEALTH PERSP, V116, pA416, DOI 10.1289/ehp.12107 Leonard H, 2010, RES AUTISM SPECT DIS, V4, P548, DOI 10.1016/j.rasd.2010.01.003 Logman JFS, 2005, AM J IND MED, V47, P37, DOI 10.1002/ajim.20102 McCanlies EC, 2012, J AUTISM DEV DISORD, V42, P2323, DOI 10.1007/s10803-012-1468-1 Mendola P, 2002, MENT RETARD DEV D R, V8, P188, DOI 10.1002/mrdd.10033 Minnesota Department of Health, 2010, TRICL FACT SHEET Newschaffer C. J., 2007, ANNU REV PUBL HEALTH, V28, P211 Palmer RF, 2009, HEALTH PLACE, V15, P18, DOI 10.1016/j.healthplace.2008.02.001 Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168 Schechter R, 2008, ARCH GEN PSYCHIAT, V65, P19, DOI 10.1001/archgenpsychiatry.2007.1 Slama R, 2007, ENVIRON HEALTH PERSP, V115, P1283, DOI 10.1289/ehp.10047 Volk HE, 2011, ENVIRON HEALTH PERSP, V119, P873, DOI 10.1289/ehp.1002835 Watanabe Nobue, 2001, Environmental Health Perspectives, V109, P111, DOI 10.2307/3434762 Wilhelm M, 2003, ENVIRON HEALTH PERSP, V111, P207, DOI 10.1289/ehp.5688 Windham GC, 2009, AUTISM RES, V2, P183, DOI 10.1002/aur.84 Windham GC, 2011, J AUTISM DEV DISORD, V41, P1362, DOI 10.1007/s10803-010-1160-2 Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120 NR 36 TC 4 Z9 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD FEB PY 2013 VL 6 IS 1 BP 57 EP 63 DI 10.1002/aur.1275 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 094YB UT WOS:000315300300007 PM 23361991 ER PT J AU Cukier, HN Lee, JM Ma, DQ Young, JI Mayo, V Butler, BL Ramsook, SS Rantus, JA Abrams, AJ Whitehead, PL Wright, HH Abramson, RK Haines, JL Cuccaro, ML Pericak-Vance, MA Gilbert, JR AF Cukier, Holly N. Lee, Joycelyn M. Ma, Deqiong Young, Juan I. Mayo, Vera Butler, Brittany L. Ramsook, Sandhya S. Rantus, Joseph A. Abrams, Alexander J. Whitehead, Patrice L. Wright, Harry H. Abramson, Ruth K. Haines, Jonathan L. Cuccaro, Michael L. Pericak-Vance, Margaret A. Gilbert, John R. TI The Expanding Role of MBD Genes in Autism: Identification of a MECP2 Duplication and Novel Alterations in MBD5, MBD6, and SETDB1 SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders (ASDs); copy number variation (CNV); methyl-CpG-binding domain (MBD); Rett syndrome; single nucleotide polymorphism (SNP) ID CPG BINDING-PROTEIN; COMPARATIVE GENOMIC HYBRIDIZATION; SEVERE MENTAL-RETARDATION; DE-NOVO MUTATIONS; RETT-SYNDROME; METHYL-CPG; COPY-NUMBER; INTELLECTUAL DISABILITY; DEVELOPMENTAL DISORDERS; NEUROLOGICAL SYMPTOMS AB The methyl-CpG-binding domain (MBD) gene family was first linked to autism over a decade ago when Rett syndrome, which falls under the umbrella of autism spectrum disorders (ASDs), was revealed to be predominantly caused by MECP2 mutations. Since that time, MECP2 alterations have been recognized in idiopathic ASD patients by us and others. Individuals with deletions across the MBD5 gene also present with ASDs, impaired speech, intellectual difficulties, repetitive behaviors, and epilepsy. These findings suggest that further investigations of the MBD gene family may reveal additional associations related to autism. We now describe the first study evaluating individuals with ASD for rare variants in four autosomal MBD family members, MBD5, MBD6, SETDB1, and SETDB2, and expand our initial screening in the MECP2 gene. Each gene was sequenced over all coding exons and evaluated for copy number variations in 287 patients with ASD and an equal number of ethnically matched control individuals. We identified 186 alterations through sequencing, approximately half of which were novel (96 variants, 51.6%). We identified 17 ASD specific, nonsynonymous variants, four of which were concordant in multiplex families: MBD5 Tyr1269Cys, MBD6 Arg883Trp, MECP2 Thr240Ser, and SETDB1 Pro1067del. Furthermore, a complex duplication spanning of the MECP2 gene was identified in two brothers who presented with developmental delay and intellectual disability. From our studies, we provide the first examples of autistic patients carrying potentially detrimental alterations in MBD6 and SETDB1, thereby demonstrating that the MBD gene family potentially plays a significant role in rare and private genetic causes of autism. Autism Res 2012, 5: 385-397. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Cukier, Holly N.; Lee, Joycelyn M.; Ma, Deqiong; Young, Juan I.; Mayo, Vera; Butler, Brittany L.; Ramsook, Sandhya S.; Rantus, Joseph A.; Abrams, Alexander J.; Whitehead, Patrice L.; Cuccaro, Michael L.; Pericak-Vance, Margaret A.; Gilbert, John R.] Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Miami, FL 33136 USA. [Ma, Deqiong; Young, Juan I.; Cuccaro, Michael L.; Pericak-Vance, Margaret A.; Gilbert, John R.] Univ Miami, Miller Sch Med, Dept Human Genet, Dr John T Macdonald Fdn, Miami, FL 33136 USA. [Wright, Harry H.; Abramson, Ruth K.] Univ S Carolina, Dept Neuropsychiat & Behav Sci, Columbia, SC 29208 USA. [Haines, Jonathan L.] Vanderbilt Univ, Ctr Human Genet Res, Nashville, TN USA. RP Pericak-Vance, MA (reprint author), Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Dr John T Macdonald Fdn, 1501 NW 10th Ave,BRB 314,M860, Miami, FL 33136 USA. EM mpericak@med.miami.edu; jgilbert@med.miami.edu RI Haines, Jonathan/C-3374-2012 FU National Institute of Mental Health [R01 MH080647]; National Institute of Neurological Disorders and Stroke [P01 NS026630] FX We are extremely thankful to all participants and their family members, without whom this study would not be possible. We acknowledge Dr. Susan Folstein for her work in ascertaining a subset of the ASD families used in this study. Funding for this study was provided by the National Institute of Mental Health (R01 MH080647), the National Institute of Neurological Disorders and Stroke (P01 NS026630 and ARRA supplement), as well as a generous gift from the Hussman Foundation. The authors declare that there is no conflict of interest. CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248 Allan AM, 2008, HUM MOL GENET, V17, P2047, DOI 10.1093/hmg/ddn102 Allen NC, 2008, NAT GENET, V40, P827, DOI 10.1038/ng.171 American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Amir RE, 1999, NAT GENET, V23, P185 Avramopoulos D, 2007, GENET MED, V9, P745, DOI 10.1097/GIM.0b013e318159a37c Ballestar E, 2005, HUM GENET, V116, P91, DOI 10.1007/s00439-004-1200-0 Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078 Bienvenu T, 2006, NAT REV GENET, V7, P415, DOI 10.1038/nrg1878 Bogdanovic O, 2009, CHROMOSOMA, V118, P549, DOI 10.1007/s00412-009-0221-9 Bourdon Violaine, 2003, Mol Diagn, V7, P3, DOI 10.2165/00066982-200307010-00002 Bunyan DJ, 2008, GENET TEST, V12, P373, DOI 10.1089/gte.2008.0012 Buyse IM, 2000, AM J HUM GENET, V67, P1428, DOI 10.1086/316913 Campos M, 2007, BRAIN DEV-JPN, V29, P293, DOI 10.1016/j.braindev.2006.09.012 Carney RM, 2003, PEDIATR NEUROL, V28, P205, DOI 10.1016/S0887-8994(02)00624-0 Carvalho CMB, 2009, HUM MOL GENET, V18, P2188, DOI 10.1093/hmg/ddp151 Chahrour M, 2008, SCIENCE, V320, P1224, DOI 10.1126/science.1153252 Cho S, 2012, GENE EXPR PATTERNS, V12, P213, DOI 10.1016/j.gep.2012.03.005 Chung BHY, 2012, EUR J HUM GENET, V20, P398, DOI 10.1038/ejhg.2011.199 Chung BHY, 2011, AM J MED GENET A, V155A, P424, DOI 10.1002/ajmg.a.33821 Cooper GM, 2005, GENOME RES, V15, P901, DOI 10.1101/gr.3577405 Coutinho AM, 2007, AM J MED GENET B, V144B, P475, DOI 10.1002/ajmg.b.30490 Cukier HN, 2011, AM J MED GENET B, V156B, P493, DOI 10.1002/ajmg.b.31188 Cukier HN, 2010, NEUROGENETICS, V11, P291, DOI 10.1007/s10048-009-0228-7 del Gaudio D, 2006, GENET MED, V8, P784, DOI 10.1097/01.gim.0000250502.28516.3c de Vries BBA, 2005, AM J HUM GENET, V77, P606, DOI 10.1086/491719 Dodge JE, 2004, MOL CELL BIOL, V24, P2478, DOI 10.1128/MCB.24.6.2478-2486.2004 Endele S, 2010, NAT GENET, V42, P1021, DOI 10.1038/ng.677 Griswold AJ, 2012, HUM MOL GENET, V21, P3513, DOI 10.1093/hmg/dds164 Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899 Harvey CG, 2007, AM J MED GENET B, V144B, P355, DOI 10.1002/ajmg.b.30425 Jaillard S., 2008, J MED GENET, V46, P847 Jiang Y, 2010, J NEUROSCI, V30, P7152, DOI 10.1523/JNEUROSCI.1314-10.2010 Jiang Y., 2010, NEUROPHARMACOLOGY, V60, P1088 Klauck SM, 2002, AM J HUM GENET, V70, P1034, DOI 10.1086/339553 Koolen DA, 2004, CLIN GENET, V65, P429, DOI 10.1111/j.1399-0004.2004.00245.x Kumar P, 2009, NAT PROTOC, V4, P1073, DOI 10.1038/nprot.2009.86 Laget S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011982 Le Guezennec X, 2006, MOL CELL BIOL, V26, P843, DOI 10.1128/MCB.26.3.843-851.2006 Li H, 2005, BRAIN DEV-JPN, V27, P321, DOI 10.1016/j.braindev.2004.08.003 Li MR, 2007, J HUM GENET, V52, P38, DOI 10.1007/s10038-006-0079-0 Lugtenberg D, 2009, EUR J HUM GENET, V17, P444, DOI 10.1038/ejhg.2008.208 Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x Matarazzo MR, 2007, J CELL PHYSIOL, V210, P711, DOI 10.1002/jcp.20879 McGraw CM, 2011, SCIENCE, V333, P186, DOI 10.1126/science.1206593 Meins M, 2005, J MED GENET, V42, DOI 10.1136/jmg.2004.023804 Moretti P, 2006, CURR OPIN GENET DEV, V16, P276, DOI 10.1016/j.gde.2006.04.009 Myers RA, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001318 Noh GJ, 2012, EUR J MED GENET, V55, P59, DOI 10.1016/j.ejmg.2011.10.001 O'Roak BJ, 2011, NAT GENET, V43, P585, DOI 10.1038/ng.835 Patterson N, 2006, PLOS GENET, V2, pe190, DOI DOI 10.1371/JOURNAL.PGEN.0020190 Price AL, 2006, NAT GENET, V38, P904, DOI 10.1038/ng1847 Quenard A, 2006, EUR J MED GENET, V49, P313, DOI 10.1016/j.ejmg.2005.11.002 Ramocki MB, 2009, ANN NEUROL, V66, P771, DOI 10.1002/ana.21715 Roloff TC, 2003, BMC GENOMICS, V4, DOI 10.1186/1471-2164-4-1 Rutter M., 2003, AUTISM DIAGNOSTIC IN Rutter M., 2003, SOCIAL COMMUNICATION Safran M., 2010, GENECARDS VERSION 3 Salyakina D, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026049 Samaco RC, 2011, J NEUROSCI, V31, P7951, DOI 10.1523/JNEUROSCI.0169-11.2011 Sarraf SA, 2004, MOL CELL, V15, P595, DOI 10.1016/j.molcel.2004.06.043 Shahbazian MD, 2002, NEURON, V35, P243, DOI 10.1016/S0896-6273(02)00768-7 Shahbazian MD, 2002, HUM MOL GENET, V11, P115, DOI 10.1093/hmg/11.2.115 Shibayama A, 2004, AM J MED GENET B, V128B, P50, DOI 10.1002/ajmg.b.30016 Siepel A, 2005, GENOME RES, V15, P1034, DOI 10.1101/gr.3715005 Sparrow SS, 2005, VINELAND ADAPTIVE BE Talkowski ME, 2011, AM J HUM GENET, V89, P551, DOI 10.1016/j.ajhg.2011.09.011 van Bon B. W., 2009, EUROPEAN J HUMAN GEN, V18, P163 Van Esch H, 2005, AM J HUM GENET, V77, P442, DOI 10.1086/444549 Vissers LELM, 2003, AM J HUM GENET, V73, P1261, DOI 10.1086/379977 Wagenstaller J, 2007, AM J HUM GENET, V81, P768, DOI 10.1086/521274 Watson P, 2001, J MED GENET, V38, P224, DOI 10.1136/jmg.38.4.224 Williams SR, 2009, EUR J HUM GENET, V18, P436 Wong VCN, 2007, J CHILD NEUROL, V22, P1397, DOI 10.1177/0883073807307091 Yang L, 2002, ONCOGENE, V21, P148, DOI 10.1038/sj.onc.1204998 Yntema HG, 2002, AM J MED GENET, V107, P81, DOI 10.1002/ajmg.10085 Zhao XY, 2003, P NATL ACAD SCI USA, V100, P6777, DOI 10.1073/pnas.1131928100 NR 77 TC 18 Z9 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2012 VL 5 IS 6 BP 385 EP 397 DI 10.1002/aur.1251 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 083KU UT WOS:000314463300001 PM 23055267 ER PT J AU South, M Newton, T Chamberlain, PD AF South, Mikle Newton, Tiffani Chamberlain, Paul D. TI Delayed Reversal Learning and Association With Repetitive Behavior in Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE behavioral analysis of animal models; animal models; animal models; cognitive neuroscience; psychopathology ID AMYGDALA THEORY; HUMAN BRAIN; FEAR; CHILDREN; DEFICITS; ANXIETY; HUMANS; MODEL; MICE AB An important aspect of successful emotion regulation is the ability to adjust emotional responses to changing environmental cues. Difficulties with such adaptation may underlie both marked symptoms of behavioral inflexibility and frequent severe anxiety in the autism spectrum disorders (ASDs). Thirty children and adolescents diagnosed with ASD and 29 age-and intelligence quotient-matched controls completed a reversal learning paradigm following partial reinforcement Pavlovian fear conditioning, using a surprising air puff as the unconditioned stimulus. After initial reversal of cue contingencies, where a previously safe cue now predicted the air puff threat, the control group but not the ASD group responded more strongly to the new threat cue. The ASD group showed evidence for reversal learning only during later trials. Reversal learning in the ASD group was significantly negatively correlated with everyday symptoms of behavioral inflexibility but not with everyday anxiety. Understanding shared associations between inflexibility, anxiety, and autism, with regard both to clinical symptoms and neurobiological mechanisms, can provide important markers for better characterizing the substantial heterogeneity across the autism spectrum. Autism Res 2012, 5: 398-406. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [South, Mikle] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA. [South, Mikle] Brigham Young Univ, Dept Neurosci, Provo, UT 84602 USA. [Newton, Tiffani; Chamberlain, Paul D.] Brigham Young Univ, Ctr Neurosci, Provo, UT 84602 USA. RP South, M (reprint author), Brigham Young Univ, 245 TLRB, Provo, UT 84602 USA. EM south@byu.edu RI South, Mikle/H-4978-2013 OI South, Mikle/0000-0003-0152-1257 FU ORCA Student Research awards; Mentored Environment Grant FX We thank the participants and their families for dedication to research in autism. Thanks to Whitney Ernst and Sarah White for their contributions to data analysis and discussion. This work was supported by ORCA Student Research awards to TN and PDC and by a Mentored Environment Grant to MS. CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005 Amodeo DA, 2012, BEHAV BRAIN RES, V227, P64, DOI 10.1016/j.bbr.2011.10.032 Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002 Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7 Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x Bernier R, 2005, J AUTISM DEV DISORD, V35, P575, DOI 10.1007/s10803-005-0002-0 Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524 Dunsmoor JE, 2007, BEHAV NEUROSCI, V121, P635, DOI 10.1037/0735-7044.121.4.635 Gaigg SB, 2008, NEUROPSYCHOLOGIA, V46, P2336, DOI 10.1016/j.neuropsychologia.2008.03.008 Gaigg SB, 2007, NEUROPSYCHOLOGIA, V45, P2125, DOI 10.1016/j.neuropsychologia.2007.01.012 Gaigg SB, 2009, J AUTISM DEV DISORD, V39, P1211, DOI 10.1007/s10803-009-0719-2 Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006 Gjevik E, 2011, J AUTISM DEV DISORD, V41, P761, DOI 10.1007/s10803-010-1095-7 Izquierdo A, 2007, P NATL ACAD SCI USA, V104, P14128, DOI 10.1073/pnas.0706583104 Joosten AV, 2010, AUST OCCUP THER J, V57, P366, DOI 10.1111/j.1440-1630.2009.00835.x Kana RK, 2011, PHYS LIFE REV, V8, P410, DOI 10.1016/j.plrev.2011.10.001 Kim J, 2005, NEUROBIOL LEARN MEM, V83, P125, DOI 10.1016/j.nlm.2004.10.003 Klin A, 2005, J AUTISM DEV DISORD, V35, P221, DOI 10.1007/s10803-005-2001-6 LABAR KS, 1995, J NEUROSCI, V15, P6846 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lord C, 2009, BRIT J HOSP MED, V70, P132 Nauta MH, 2004, BEHAV RES THER, V42, P813, DOI 10.1016/S0005-7967(03)00200-6 Phelps EA, 2004, NEURON, V43, P897, DOI 10.1016/j.neuron.2004.08.042 Pine DS, 2001, BIOL PSYCHIAT, V50, P225, DOI 10.1016/S0006-3223(01)01159-3 Reaven JA, 2009, J SPEC PEDIATR NURS, V14, P192, DOI 10.1111/j.1744-6155.2009.00197.x Rodgers J, 2012, J AUTISM DEV DISORD, V42, P175, DOI 10.1007/s10803-011-1225-x Rutter M., 2003, SOCIAL COMMUNICATION Salmond CH, 2003, PHILOS T ROY SOC B, V358, P405, DOI 10.1098/rstb.2002.1210 Schiller D, 2008, J NEUROSCI, V28, P11517, DOI 10.1523/JNEUROSCI.2265-08.2008 Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851 Solomon M, 2011, AUTISM RES, V4, P109, DOI 10.1002/aur.177 South M, 2007, AUTISM, V11, P437, DOI 10.1177/1362361307079606 South M., 2012, AUTISM RES, V4, P412 Stack CM, 2008, EXP NEUROL, V211, P67, DOI 10.1016/j.expneurol.2008.01.003 Stanton ME, 2007, BEHAV BRAIN RES, V176, P133, DOI 10.1016/j.bbr.2006.10.022 NR 35 TC 8 Z9 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2012 VL 5 IS 6 BP 398 EP 406 DI 10.1002/aur.1255 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 083KU UT WOS:000314463300002 PM 23097376 ER PT J AU Ho, JS Radoeva, PD Jalbrzikowski, M Chow, C Hopkins, J Tran, WC Mehta, A Enrique, N Gilbert, C Antshel, KM Fremont, W Kates, WR Bearden, CE AF Ho, Jennifer S. Radoeva, Petya D. Jalbrzikowski, Maria Chow, Carolyn Hopkins, Jessica Tran, Wen-Ching Mehta, Ami Enrique, Nicole Gilbert, Chelsea Antshel, Kevin M. Fremont, Wanda Kates, Wendy R. Bearden, Carrie E. TI Deficits in Mental State Attributions in Individuals with 22q11.2 Deletion Syndrome (Velo-Cardio-Facial Syndrome) SO AUTISM RESEARCH LA English DT Article DE 22q11.2 deletion syndrome; Velo-cardio-facial syndrome; Theory of Mind; Autism Spectrum Disorders; reciprocal social behavior; social cognition ID AUTISM SPECTRUM DISORDERS; VELOCARDIOFACIAL SYNDROME; DIAGNOSTIC INTERVIEW; SOCIAL COGNITION; ANIMATED SHAPES; VOLUMETRIC MRI; NEURAL BASIS; SCHIZOPHRENIA; CHILDREN; MIND AB Velo-cardio-facial syndrome (VCFS; 22q11.2 deletion syndrome) results from a genetic mutation that increases risk for Autism Spectrum Disorder (ASD). We compared Theory of Mind (ToM) skills in 63 individuals with VCFS (25% with an ASD diagnosis) and 43 typically developing controls, and investigated the relationship of ToM to reciprocal social behavior. We administered a video-based task to assess mentalizing at two sites University of California, Los Angeles (UCLA) and State University of New York (SUNY) Upstate Medical University. The videos depicted interactions representing complex mental states (ToM condition), or simple movements (Random condition). Verbal descriptions of the videos were rated for Intentionality (i.e. mentalizing) and Appropriateness. Using Repeated Measures analysis of variance (ANOVA), we assessed the effects of VCFS and ASD on Intentionality and Appropriateness, and the relationship of mentalizing to Social Responsiveness Scale (SRS) scores. Results indicated that individuals with VCFS overall had lower Intentionality and Appropriateness scores than controls for ToM but not for Random scenes. In the SUNY sample, individuals with VCFS, both with and without ASD, performed more poorly than controls on the ToM condition; however, in the UCLA sample, only individuals with VCFS without ASD performed significantly worse than controls on the ToM condition. Controlling for site and age, performance on the ToM condition was significantly correlated with SRS scores. Individuals with VCFS, regardless of an ASD diagnosis, showed impairments in the spontaneous attribution of mental states to abstract visual stimuli, which may underlie real-life problems with social interactions. A better understanding of the social deficits in VCFS is essential for the development of targeted behavioral interventions. Autism Res 2012, 5: 407-418. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Ho, Jennifer S.; Chow, Carolyn; Hopkins, Jessica; Tran, Wen-Ching; Mehta, Ami; Enrique, Nicole; Gilbert, Chelsea; Bearden, Carrie E.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA. [Radoeva, Petya D.] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA. [Jalbrzikowski, Maria; Bearden, Carrie E.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA. [Antshel, Kevin M.; Fremont, Wanda; Kates, Wendy R.] SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY 13210 USA. RP Bearden, CE (reprint author), UCLA Psychiat & Biobehav Sci, BOX 956968,300 Med Plaza,Rm 2267, Los Angeles, CA 90095 USA. EM cbearden@mednet.ucla.edu FU NIH/NICHD [P50-HD-055784]; NIH/NIMH [RO1 MH085953, MH064824]; Autism Speaks [7076]; National Institute of Mental Health [R01 MH085953, R01 MH64824]; Dennis Weatherstone Pre-Doctoral Fellowship from Autism Speaks [7076] FX Grant sponsor: NIH/NICHD; Grant number: P50-HD-055784 (CART Pilot Project Grant to CEB)Grant sponsor: NIH/NIMH; Grant number: RO1 MH085953 (CEB)Grant sponsor: NIH/NIMH; Grant number: MH064824 (WRK)Grant sponsor: Autism Speaks; Grant number: 7076 (Dennis Weatherstone Pre-Doctoral Fellowship to PDR)The funding sources for the study included grants from the National Institute of Mental Health (R01 MH085953 to CEB; R01 MH64824 to WRK), NIH/NICHD (P50-HD-055784 (CART Pilot Project Grant to CEB)) and the Dennis Weatherstone Pre-Doctoral Fellowship from Autism Speaks (#7076 to PDR). Special thanks to Dr. Robert J. Shprintzen, a co-investigator on the R01 MH64824 grant, Anne Marie Higgins and Jo-Anna Botti for coordination of the longitudinal study at SUNY Upstate Medical University, Kelly Wallace and Jo-Anna Botti for assistance with transcription of verbal responses of participants at the SUNY site, Lauren Sanderson for assistance with the overall project, and Christopher McCarthy for administering the ToM paradigm to some of the participants at the SUNY site. CR Abdi Z, 2004, CNS SPECTRUMS, V9, P335 Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9 Adolphs R, 2009, ANNU REV PSYCHOL, V60, P693, DOI 10.1146/annurev.psych.60.110707.163514 Antshel KM, 2010, J AM ACAD CHILD PSY, V49, P333, DOI 10.1016/j.jaac.2010.01.010 Antshel KM, 2006, J AM ACAD CHILD PSY, V45, P596, DOI 10.1097/01.chi.0000205703 Antshel KM, 2007, J AUTISM DEV DISORD, V37, P1776, DOI 10.1007/s10803-006-0308-6 Baker KD, 2005, BRIT J PSYCHIAT, V186, P115, DOI 10.1192/bjp.186.2.115 BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 Bearden CE, 2001, J CLIN EXP NEUROPSYC, V23, P447, DOI 10.1076/jcen.23.4.447.1228 Bearden CE, 2009, CEREB CORTEX, V19, P115, DOI 10.1093/cercor/bhn064 BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289 Campbell LE, 2009, NEUROPSYCHOLOGIA, V47, P1034, DOI 10.1016/j.neuropsychologia.2008.10.029 Campbell L.E., 2011, J NEURODEVELOPMENTAL, V3, P1 Campbell R, 2006, DEV PSYCHOPATHOL, V18, P99, DOI 10.1017/S0954579406060068 Castelli F, 2000, NEUROIMAGE, V12, P314, DOI 10.1006/nimg.2000.0612 Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189 Chow EWC, 2006, SCHIZOPHR RES, V87, P270, DOI 10.1016/j.schres.2006.04.007 Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014 Eliez S, 2000, AM J PSYCHIAT, V157, P409, DOI 10.1176/appi.ajp.157.3.409 Feinstein C, 2007, CHILD ADOL PSYCH CL, V16, P631, DOI 10.1016/j.chc.2007.03.006 Fine SE, 2005, J AUTISM DEV DISORD, V35, P461, DOI 10.1007/s10803-005-5036-9 First M.B., 1997, STRUCTURED CLIN INTE First M.B., 2009, STRUCTURED CLIN INTE Frankel F, 2010, J AUTISM DEV DISORD, V40, P827, DOI 10.1007/s10803-009-0932-z Frith CD, 2004, PSYCHOL MED, V34, P385, DOI 10.1017/S0033291703001326 Green T, 2009, J AM ACAD CHILD PSY, V48, P1060, DOI 10.1097/CHI.0b013e3181b76683 Horan WP, 2011, J PSYCHIATR RES, V45, P1113, DOI 10.1016/j.jpsychires.2011.01.015 Horan WP, 2009, PSYCHOL MED, V39, P635, DOI 10.1017/S0033291708003838 Kates WR, 2007, AM J MED GENET A, V143A, P2642, DOI 10.1002/ajmg.a.32012 Kates WR, 2001, BIOL PSYCHIAT, V49, P677, DOI 10.1016/S0006-3223(00)01002-7 Kaufman AS, 1999, ESSENTIALS WAIS 3 AS Kaufmann WE, 2004, AM J MED GENET A, V129A, P225, DOI 10.1002/ajmg.a.30229 Kiley-Brabeck K, 2006, APPL NEUROPSYCHOL, V13, P258, DOI 10.1207/s15324826an1304_7 Kobrynski LJ, 2007, LANCET, V370, P1443, DOI 10.1016/S0140-6736(07)61601-8 Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 McDonald-McGinn DM, 2001, GENET MED, V3, P23, DOI 10.1097/00125817-200101000-00006 McGlashan TH, 2001, SCHIZOPHRENIA BULL, V27, P563 Murphy KC, 2002, LANCET, V359, P426, DOI 10.1016/S0140-6736(02)07604-3 Niklasson L, 2002, DEV MED CHILD NEUROL, V44, P44, DOI 10.1017/S0012162201001645 OVERALL JE, 1962, PSYCHOL REP, V10, P799 Pinkham AE, 2003, AM J PSYCHIAT, V160, P815, DOI 10.1176/appi.ajp.160.5.815 PREMACK D, 1978, BEHAV BRAIN SCI, V1, P515 Shaffer D, 2000, J AM ACAD CHILD PSY, V39, P28, DOI 10.1097/00004583-200001000-00014 Shprintzen R. J., 2005, PROGR PEDIAT CARDIOL, V20, P187, DOI 10.1016/j.ppedcard.2005.04.009 Swillen A, 2005, DEV MED CHILD NEUROL, V47, P797, DOI 10.1017/S0012162205001696 Vorstman JAS, 2006, J AM ACAD CHILD PSY, V45, P1104, DOI 10.1097/01.chi.0000228131.56956.cl Wechsler D., 1991, WISC 3 WECHSLER INTE Wechsler D, 1999, WECHSLER ABBREVIATED Wolwer W, 2011, SCHIZOPHRENIA BULL, V37, pS63, DOI 10.1093/schbul/sbr071 NR 51 TC 7 Z9 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2012 VL 5 IS 6 BP 407 EP 418 DI 10.1002/aur.1252 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 083KU UT WOS:000314463300003 PM 22962003 ER PT J AU Gondalia, SV Palombo, EA Knowles, SR Cox, SB Meyer, D Austin, DW AF Gondalia, Shakuntla V. Palombo, Enzo A. Knowles, Simon R. Cox, Stephen B. Meyer, Denny Austin, David W. TI Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings SO AUTISM RESEARCH LA English DT Article DE faecal microbiota; pyrosequencing; autism spectrum disorder; gastrointestinal dysfunction ID TAG-ENCODED FLX; AMPLICON PYROSEQUENCING BTEFAP; SPECTRUM DISORDERS; BACTERIAL DIVERSITY; SOCIAL-BEHAVIOR; ONSET AUTISM; SYMPTOMS; COMMUNITIES; INFECTIONS; MICROFLORA AB Many children with autism spectrum disorders (ASDs) suffer from gastrointestinal problems such as diarrhoea, constipation and abdominal pain. This has stimulated investigations into possible abnormalities of intestinal microbiota in autistic patients. Therefore, we designed this study to identify differences (and/or similarities) in the microbiota of children with autism (without gastrointestinal dysfunction: n = 23; with gastrointestinal dysfunction: n = 28) and their neurotypical siblings (n = 53) who share a similar environment using bacterial tag-encoded FLX amplicon pyrosequencing. Regardless of the diagnosis and sociodemographic characteristics, overall, Firmicutes (70%), Bacteroidetes (20%) and Proteobacteria (4%) were the most dominant phyla in samples. Results did not indicate clinically meaningful differences between groups. The data do not support the hypothesis that the gastrointestinal microbiota of children with ASD plays a role in the symptomatology of ASD. Other explanations for the gastrointestinal dysfunction in this population should be considered including elevated anxiety and self-restricted diets. Autism Res 2012, 5: 419-427. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Gondalia, Shakuntla V.; Palombo, Enzo A.; Knowles, Simon R.; Austin, David W.] Swinburne Univ Technol, SABRI, Fac Life & Social Sci, Hawthorn, Vic 3122, Australia. [Palombo, Enzo A.] Swinburne Univ Technol, Environm & Biotechnol Ctr, Fac Life & Social Sci, Hawthorn, Vic 3122, Australia. [Knowles, Simon R.; Austin, David W.] Swinburne Univ Technol, Brain & Psycol Sci Res Ctr, Fac Life & Social Sci, Hawthorn, Vic 3122, Australia. [Meyer, Denny] Swinburne Univ Technol, Fac Life & Social Sci, Hawthorn, Vic 3122, Australia. [Cox, Stephen B.] Res & Testing Labs, Lubbock, TX USA. RP Gondalia, SV (reprint author), Swinburne Univ Technol, SABRI, Fac Life & Social Sci, Mail H31, Hawthorn, Vic 3122, Australia. EM sgondalia@swin.edu.au CR Adams JB, 2006, BIOL TRACE ELEM RES, V110, P193, DOI 10.1385/BTER:110:3:193 Adams J. B., 2008, Toxicological and Environmental Chemistry, V90, P739, DOI 10.1080/02772240701699294 Altieri L, 2011, BIOMARKERS, V16, P252, DOI 10.3109/1354750X.2010.548010 Aziz Q, 1998, GASTROENTEROLOGY, V114, P559, DOI 10.1016/S0016-5085(98)70540-2 Bolte ER, 1998, MED HYPOTHESES, V51, P133, DOI 10.1016/S0306-9877(98)90107-4 Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303 Dowd SE, 2008, BMC MICROBIOL, V8, DOI 10.1186/1471-2180-8-43 Dowd SE, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003326 Dowd SE, 2005, BMC BIOINFORMATICS, V6, DOI 10.1186/1471-2105-6-93 Dowd SE, 2008, BMC MICROBIOL, V8, DOI 10.1186/1471-2180-8-125 Dufrene M, 1997, ECOL MONOGR, V67, P345, DOI 10.2307/2963459 Fierer N, 2010, P NATL ACAD SCI USA, V107, P6477, DOI 10.1073/pnas.1000162107 Finegold SM, 2011, MED HYPOTHESES, V77, P270, DOI 10.1016/j.mehy.2011.04.032 Finegold SM, 2002, CLIN INFECT DIS, V35, pS6, DOI 10.1086/341914 Finegold SM, 2010, ANAEROBE, V16, P444, DOI 10.1016/j.anaerobe.2010.06.008 Finegold SM, 2008, MED HYPOTHESES, V70, P508, DOI 10.1016/j.mehy.2007.07.019 Gondalia SV, 2010, REV MED MICROBIOL, V21, P44, DOI 10.1097/MRM.0b013e32833a3dc9 Gondalia SV, 2010, ELECT J APPL PSYCHOL, V6, P24 Gontcharova VYE, 2010, OPEN MICROBIOL J, V4, P6, DOI DOI 10.1016/J.BIORTECH.2009.07.033 GOODWIN MS, 1971, J AUTISM CHILD SCHIZ, V1, P48, DOI 10.1007/BF01537742 Hollander E., 2008, CLIN MANUAL TREATMEN Horvath K, 1999, J PEDIATR-US, V135, P559, DOI 10.1016/S0022-3476(99)70052-1 Hutman T, 2010, J CHILD PSYCHOL PSYC, V51, P1010, DOI 10.1111/j.1469-7610.2010.02270.x Ishak HD, 2011, MICROB ECOL, V61, P821, DOI 10.1007/s00248-010-9793-4 KONSTANTAREAS MM, 1987, J AUTISM DEV DISORD, V17, P585, DOI 10.1007/BF01486973 Levy SE, 2007, BIOL PSYCHIAT, V61, P492, DOI 10.1016/j.biopsych.2006.07.013 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005 Lozupone CA, 2007, P NATL ACAD SCI USA, V104, P11436, DOI 10.1073/pnas.0611525104 Mayes SD, 2011, J DEV PHYS DISABIL, V23, P325, DOI 10.1007/s10882-011-9231-7 Mayes SD, 2011, RES AUTISM SPECT DIS, V5, P474, DOI 10.1016/j.rasd.2010.06.012 Molloy CA, 2003, AUTISM, V7, P165, DOI 10.1177/1362361303007002004 Mussell M, 2008, J PSYCHOSOM RES, V64, P605, DOI 10.1016/j.jpsychores.2008.02.019 Niehus R, 2006, J DEV BEHAV PEDIATR, V27, pS120, DOI 10.1097/00004703-200604002-00010 Oksanen FJ, 2011, VEGAN COMMUNITY ECOL O'Mahony SM, 2009, BIOL PSYCHIAT, V65, P263, DOI 10.1016/j.biopsych.2008.06.026 Parracho HMRT, 2005, J MED MICROBIOL, V54, P987, DOI 10.1099/jmm.0.46101-0 Rellini E, 2004, J AUTISM DEV DISORD, V34, P703, DOI 10.1007/s10803-004-5290-2 Roberts D. W., 2010, LABDSV ORDINATION MU Sandler RH, 2000, J CHILD NEUROL, V15, P429, DOI 10.1177/088307380001500701 Schloss PD, 2005, APPL ENVIRON MICROB, V71, P1501, DOI 10.1128/AEM.71.3.1501-1506.2005 Sen R, 2009, P NATL ACAD SCI USA, V106, P17805, DOI 10.1073/pnas.0904827106 Shultz SR, 2008, NEUROPHARMACOLOGY, V54, P901, DOI 10.1016/j.neuropharm.2008.01.013 Song YL, 2004, APPL ENVIRON MICROB, V70, P6459, DOI 10.1128/AEM.70.11.6459-6465.2004 Team R.D.C, 2010, R LANG ENV STAT COMP Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011 Wolcott RD, 2009, BMC MICROBIOL, V9, DOI 10.1186/1471-2180-9-226 Wood JJ, 2009, J CHILD PSYCHOL PSYC, V50, P224, DOI 10.1111/j.1469-7610.2008.01948.x Yap IKS, 2010, J PROTEOME RES, V9, P2996, DOI 10.1021/pr901188e NR 50 TC 17 Z9 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2012 VL 5 IS 6 BP 419 EP 427 DI 10.1002/aur.1253 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 083KU UT WOS:000314463300004 PM 22997101 ER PT J AU Abdallah, MW Pearce, BD Larsen, N Greaves-Lord, K Norgaard-Pedersen, B Hougaard, DM Mortensen, EL Grove, J AF Abdallah, Morsi W. Pearce, Brad D. Larsen, Nanna Greaves-Lord, Kirstin Norgaard-Pedersen, Bent Hougaard, David M. Mortensen, Erik L. Grove, Jakob TI Amniotic Fluid MMP-9 and Neurotrophins in Autism Spectrum Disorders: An Exploratory Study SO AUTISM RESEARCH LA English DT Article DE neuronal plasticity; autistic disorder; amniotic fluid; matrix metalloproteinase; neurotrophins ID FRAGILE-X-SYNDROME; MATRIX METALLOPROTEINASES; SYNAPTIC PLASTICITY; DANISH; MINOCYCLINE; PREVALENCE; REGISTER AB Evidence suggests that some developmental disorders, such as autism spectrum disorders (ASDs), are caused by errors in brain plasticity. Given the important role of matrix metalloproteinases (MMPs) and neurotrophins (NTs) in neuroplasticity, amniotic fluid samples for 331 ASD cases and 698 frequency-matched controls were analyzed for levels of MMP-9, brain-derived neurotrophic factor, NT-4 and transforming growth factor-beta utilizing a Danish historic birth cohort and Danish nationwide health registers. Laboratory measurements were performed using an in-house multiplex sandwich immunoassay Luminex xMAP method, and measurements were analyzed using tobit and logistic regression. Results showed elevated levels of MMP-9 in ASD cases compared with controls (crude and adjusted tobit regression P-values: 0.01 and 0.06). Our results highlight the importance of exploring the biologic impact of MMP-9 and potential therapeutic roles of its inhibitors in ASD and may indicate that neuroplastic impairments in ASD may present during pregnancy. Autism Res 2012, 5: 428-433. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Abdallah, Morsi W.] Aarhus Univ, Epidemiol Sect, Aarhus C, Denmark. [Abdallah, Morsi W.; Larsen, Nanna; Norgaard-Pedersen, Bent; Hougaard, David M.] Statens Serum Inst, Dept Clin Biochem & Immunol, Copenhagen S, Denmark. [Abdallah, Morsi W.] Univ Rostock, Dept Psychiat & Psychotherapy, Rostock Univ Hosp, D-18147 Rostock, Germany. [Pearce, Brad D.] Emory Univ, Sch Publ Hlth, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA USA. [Greaves-Lord, Kirstin] Erasmus MC Sophias Childrens Hosp, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands. [Greaves-Lord, Kirstin] Yulius Acad & Yulius Autisme, Dordrecht, Netherlands. [Mortensen, Erik L.] Univ Copenhagen, Inst Publ Hlth, Copenhagen, Denmark. [Mortensen, Erik L.] Univ Copenhagen, Ctr Hlth Aging, Copenhagen, Denmark. [Grove, Jakob] Aarhus Univ, Dept Biomed, Aarhus C, Denmark. [Grove, Jakob] Bioinformat Res Ctr BiRC, Aarhus C, Denmark. RP Abdallah, MW (reprint author), Univ Rostock, Dept Psychiat & Psychotherapy, Rostock Univ Hosp, Gehlsheimer St 20, D-18147 Rostock, Germany. EM morsi.abdallah@med.uni-rostock.de FU Aarhus University Faculty of Health Sciences, Aarhus, Denmark; Statens Serum Institute, Department of Clinical Biochemistry and Immunology, Copenhagen, Denmark [494028]; Danish Medical Research Foundation; Danish Ministry of the Interior and Health [271-05-0523/09-060179] FX This study is funded jointly by Aarhus University Faculty of Health Sciences, Aarhus, Denmark and Statens Serum Institute, Department of Clinical Biochemistry and Immunology, Copenhagen, Denmark (Project Title: Intrauterine Exposures and Childhood Psychiatric Disorders, Project ID: 494028). This study utilized the Danish historic birth cohort that was established at Statens Serum Institute in Copenhagen with a grant from The Danish Medical Research Foundation and The Danish Ministry of the Interior and Health (Project no. 271-05-0523/09-060179). CR Andersen TF, 1999, DAN MED BULL, V46, P263 Bilousova TV, 2009, J MED GENET, V46, P94, DOI 10.1136/jmg.2008.061796 Cajigas IJ, 2010, EMBO J, V29, P2746, DOI 10.1038/emboj.2010.173 Ethell IM, 2007, J NEUROSCI RES, V85, P2813, DOI 10.1002/jnr.21273 Ganea E, 2007, BIOCHEM SOC T, V35, P689 Gillberg C, 2000, ACTA PSYCHIAT SCAND, V102, P321, DOI 10.1034/j.1600-0447.2000.102005321.x Hagerman R., 2010, MOL AUTISM, V1, P1, DOI DOI 10.1186/2040-2392-1-12 Harrington JW, 2010, PEDIATRICS, V126, pE1257, DOI 10.1542/peds.2010-2305 Huang EJ, 2001, ANNU REV NEUROSCI, V24, P677, DOI 10.1146/annurev.neuro.24.1.677 Knudsen LB, 1998, DAN MED BULL, V45, P320 Krueger DD, 2011, ANNU REV MED, V62, P411, DOI 10.1146/annurev-med-061109-134644 Kugler KG, 2011, J CLIN BIOINFORMA, V1, P9, DOI DOI 10.1186/2043-9113-1-9 Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123 Lauritsen MB, 2004, PSYCHOL MED, V34, P1339, DOI 10.1017/S0033291704002387 Lauritsen MB, 2010, J AUTISM DEV DISORD, V40, P139, DOI 10.1007/s10803-009-0818-0 Luminex Corporation, 2009, CYT CHEM GROWTH FACT Markram K, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00224 McAllister AK, 1999, ANNU REV NEUROSCI, V22, P295, DOI 10.1146/annurev.neuro.22.1.295 MunkJorgensen P, 1997, DAN MED BULL, V44, P82 Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007 Nickl-Jockschat T, 2011, MOL PSYCHIATR, V16, P478, DOI 10.1038/mp.2010.103 Norgaard-Pedersen B, 2005, STATENS SERUM I ETAB Norgaard-Pedersen B, 2007, J INHERIT METAB DIS, V30, P530, DOI 10.1007/s10545-007-0631-x Paribello C, 2010, BMC NEUROL, V10, DOI 10.1186/1471-2377-10-91 Rosenberg GA, 2007, NEUROSURG FOCUS, V22, P1, DOI DOI 10.3171/FOC.2007.22.5.5 Skogstrand K, 2005, CLIN CHEM, V51, P1854, DOI 10.1373/clinchem.2005.052241 SPSS Inc, 2009, IBM PASW STAT 18 SPS StataCorp LP, 2009, STAT STAT DAT AN VER Sundhedsstyrelsen, 1986, KLASS SYGD Sundhedsstyrelsen, 2008, KLASS SYGD Vu TH, 2000, GENE DEV, V14, P2123, DOI 10.1101/gad.815400 Yong VW, 2005, NAT REV NEUROSCI, V6, P931, DOI 10.1038/nrn1807 NR 32 TC 10 Z9 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2012 VL 5 IS 6 BP 428 EP 433 DI 10.1002/aur.1254 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 083KU UT WOS:000314463300005 PM 23008271 ER PT J AU Hedrick, A Lee, Y Wallace, GL Greenstein, D Clasen, L Giedd, JN Raznahan, A AF Hedrick, Alexis Lee, Yohan Wallace, Gregory L. Greenstein, Deanna Clasen, Liv Giedd, Jay N. Raznahan, Armin TI Autism Risk Gene MET Variation and Cortical Thickness in Typically Developing Children and Adolescents SO AUTISM RESEARCH LA English DT Article DE MET receptor tyrosine kinase; cortex; autism; development; MRI ID RECEPTOR TYROSINE KINASE; HUMAN CEREBRAL-CORTEX; SPECTRUM DISORDER; ASSOCIATION; TRAITS; VALIDATION; PHENOTYPES; ANATOMY AB MET receptor tyrosine kinase (MET) has been proposed as a candidate risk gene for autism spectrum disorder (ASD) based on associations between MET polymorphisms and ASD diagnosis, as well as evidence from animal studies that MET protein may regulate early development of cortical regions implicated in the neurobiology of ASD. The relevance of differences in MET signaling for human cortical development remains unexamined, however. We sought to address this issue by relating genotype at a functional single nucleotide polymorphism within the MET promoter (rs1858830, G -> C) to in vivo measures of cortical thickness (CT) development derived from 222 healthy children and adolescents with 514 longitudinally acquired structural magnetic resonance imaging brain scans between ages 9 and 22 years. We identified a statistically significant, developmentally fixed, and stepwise CT reduction with increasing C allele dose in superior and middle temporal gyri, ventral precentral and postcentral gyri, and anterior cingulate bilaterally, and in the right frontopolar cortex. We were also able to demonstrate that mean CT within these cortical regions showed a statistically significant reduction with increasing scores on a continuous measure of autistic traits (the Social Responsiveness Scale). The cortical regions highlighted by our analyses are not only established areas of MET expression during prenatal life but are also key components of the "social brain" that have frequently shown structural and functional abnormalities in autism. Our results suggest that genetic differences in the MET gene may influence the development of cortical systems implicated in the neurobiology of ASD. Autism Res 2012, 5: 434-439. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Hedrick, Alexis; Lee, Yohan; Greenstein, Deanna; Clasen, Liv; Giedd, Jay N.; Raznahan, Armin] NIMH, Child Psychiat Branch, Bethesda, MD 20814 USA. [Wallace, Gregory L.] NIMH, Lab Brain & Cognit, Bethesda, MD 20814 USA. RP Raznahan, A (reprint author), NIMH, NIH, 10 Ctr Dr Bldg 10,Room 4C108, Bethesda, MD 20814 USA. EM raznahana@mail.nih.gov RI Giedd, Jay/B-7302-2012 OI Giedd, Jay/0000-0003-0827-3460 FU National Institutes of Health, National Institute of Mental Health Intramural Research; UK MRC Clinical Research Training Grant [G0701370] FX This research was supported by the National Institutes of Health, National Institute of Mental Health Intramural Research, and a UK MRC Clinical Research Training Grant awarded to A.R. (G0701370). We thank the participants and families who took part in this study. CR Ad-Dab'bagh Y., 2006, CIVET IMAGE PROCESSI Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Birchmeier C, 1998, TRENDS CELL BIOL, V8, P404, DOI 10.1016/S0962-8924(98)01359-2 Bolte S, 2011, J AUTISM DEV DISORD, V41, P66, DOI 10.1007/s10803-010-1024-9 Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103 Campbell DB, 2009, EUR J HUM GENET, V17, P699, DOI 10.1038/ejhg.2008.217 Campbell DB, 2010, AM J MED GENET B, V153B, P438, DOI 10.1002/ajmg.b.30998 Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180 Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27 Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x Giedd JN, 1996, CEREB CORTEX, V6, P551, DOI 10.1093/cercor/6.4.551 Gillis RF, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-12 Gutierrez H, 2004, DEVELOPMENT, V131, P3717, DOI 10.1242/dev.01209 Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069 Hariri AR, 2006, BIOL PSYCHIAT, V59, P888, DOI 10.1016/j.biopsych.2005.11.005 Hawkins JR, 2002, HUM MUTAT, V19, P543, DOI 10.1002/humu.10060 Herbeck JT, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006915 Jackson PB, 2009, AUTISM RES, V2, P232, DOI 10.1002/aur.87 Judson MC, 2011, J NEURODEV DISORD, V3, P282, DOI 10.1007/s11689-011-9081-8 Judson MC, 2010, J COMP NEUROL, V518, P4463, DOI 10.1002/cne.22467 Kabani N, 2001, NEUROIMAGE, V13, P375, DOI 10.1006/nimg.2000.0652 Lenroot RK, 2009, HUM BRAIN MAPP, V30, P163, DOI 10.1002/hbm.20494 Lerch JP, 2005, NEUROIMAGE, V24, P163, DOI 10.1016/j.neuroimage.2004.07.045 Meyer-Lindenberg A, 2010, PSYCHOL MED, V40, P1057, DOI 10.1017/S0033291709991929 Powell EM, 2001, NEURON, V30, P79, DOI 10.1016/S0896-6273(01)00264-1 Qiu SF, 2011, J NEUROSCI, V31, P5855, DOI 10.1523/JNEUROSCI.6569-10.2011 Raznahan A, 2011, MOL PSYCHIATR, V16, P917, DOI 10.1038/mp.2010.72 Raznahan A, 2010, NEUROIMAGE, V49, P2915, DOI 10.1016/j.neuroimage.2009.11.057 Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198 Shaw P, 2008, J NEUROSCI, V28, P3586, DOI 10.1523/JNEUROSCI.5309-07.2008 Sousa I, 2009, EUR J HUM GENET, V17, P749, DOI 10.1038/ejhg.2008.215 State MW, 2011, NAT NEUROSCI, V14, P1499, DOI 10.1038/nn.2924 Thanseem I, 2010, NEUROSCI RES, V68, P137, DOI 10.1016/j.neures.2010.06.014 Voineagu I, 2011, NATURE, V474, P380, DOI 10.1038/nature10110 Wallace G.L., 2011, BRAIN, V133, P3745 Wallace GL, 2012, J NEUROSCI, V32, P4856, DOI 10.1523/JNEUROSCI.6214-11.2012 NR 38 TC 8 Z9 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2012 VL 5 IS 6 BP 434 EP 439 DI 10.1002/aur.1256 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 083KU UT WOS:000314463300006 PM 23097380 ER PT J AU Travers, BG Adluru, N Ennis, C Tromp, DPM Destiche, D Doran, S Bigler, ED Lange, N Lainhart, JE Alexander, AL AF Travers, Brittany G. Adluru, Nagesh Ennis, Chad Tromp, Do P. M. Destiche, Dan Doran, Sam Bigler, Erin D. Lange, Nicholas Lainhart, Janet E. Alexander, Andrew L. TI Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review SO AUTISM RESEARCH LA English DT Review DE diffusion tensor imaging; neuroimaging; autism; white matter ID WHITE-MATTER MICROSTRUCTURE; HIGH-FUNCTIONING AUTISM; SUPERIOR TEMPORAL SULCUS; VOXEL-BASED MORPHOMETRY; DEFAULT MODE NETWORK; CORPUS-CALLOSUM SIZE; HUMAN BRAIN; STRUCTURAL CONNECTIVITY; HEAD CIRCUMFERENCE; IN-VIVO AB White matter tracts of the brain allow neurons and neuronal networks to communicate and function with high efficiency. The aim of this review is to briefly introduce diffusion tensor imaging methods that examine white matter tracts and then to give an overview of the studies that have investigated white matter integrity in the brains of individuals with autism spectrum disorder (ASD). From the 48 studies we reviewed, persons with ASD tended to have decreased fractional anisotropy and increased mean diffusivity in white matter tracts spanning many regions of the brain but most consistently in regions such as the corpus callosum, cingulum, and aspects of the temporal lobe. This decrease in fractional anisotropy was often accompanied by increased radial diffusivity. Additionally, the review suggests possible atypical lateralization in some white matter tracts of the brain and a possible atypical developmental trajectory of white matter microstructure in persons with ASD. Clinical implications and future research directions are discussed. Autism Res 2012, 5: 289313. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Travers, Brittany G.] Univ Wisconsin, Waisman Ctr, Waisman Lab Brain Imaging & Behav, Madison, WI 53705 USA. [Bigler, Erin D.] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA. [Lange, Nicholas] Harvard Univ, Dept Psychiat, Boston, MA 02115 USA. [Lange, Nicholas] Harvard Univ, Dept Biostat, Boston, MA 02115 USA. [Lange, Nicholas] McLean Hosp, Neurostat Lab, Belmont, MA 02178 USA. [Lainhart, Janet E.] Univ Utah, Dept Psychiat, Salt Lake City, UT USA. [Lainhart, Janet E.] Univ Utah, Neurosci Program, Salt Lake City, UT USA. [Lainhart, Janet E.] Univ Utah, Inst Brain, Salt Lake City, UT USA. [Alexander, Andrew L.] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA. [Alexander, Andrew L.] Univ Wisconsin, Dept Psychiat, Madison, WI 53705 USA. RP Travers, BG (reprint author), Univ Wisconsin, Waisman Ctr, Waisman Lab Brain Imaging & Behav, 1500 Highland Ave, Madison, WI 53705 USA. EM btravers@wisc.edu FU National Institute of Child Health and Human Development (NICHD) [T32 HD07 489, P30 HD003352]; National Institute of Mental Health (NIMH) [P50 MH84051, RO1 MH080826]; Morgridge Institutes for Research (MIR-University of Wisconsin) FX This work was supported by National Institute of Child Health and Human Development (NICHD) T32 HD07 489 Postdoctoral Training Award (BGT); NICHD P30 HD003352 (ALA); National Institute of Mental Health (NIMH) P50 MH84051 (ALA), NIMH RO1 MH080826 (JEL, ALA, EDB, NL), the Morgridge Institutes for Research (MIR-University of Wisconsin; NA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIMH, NICHD, or the NIH. The authors would also like to thank Frances Haeberli and Bimi Pangli for their assistance with selecting and reviewing the articles. CR ADLURU N, 2009, C P IEEE ENG MED BIO, P2719, DOI DOI 10.1109/IEMBS.2009.5333386 Alexander Andrew L, 2011, Brain Connect, V1, P423, DOI 10.1089/brain.2011.0071 Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032 Alexander AL, 2001, MAGN RESON MED, V45, P770, DOI 10.1002/mrm.1105 Alexander AL, 2007, NEUROTHERAPEUTICS, V4, P316, DOI 10.1016/j.nurt.2007.05.011 Alexander AL, 2000, MAGNET RESON MED, V44, P283, DOI 10.1002/1522-2594(200008)44:2<283::AID-MRM16>3.0.CO;2-V Allison T, 2000, TRENDS COGN SCI, V4, P267, DOI 10.1016/S1364-6613(00)01501-1 Ameis SH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028044 American Psychiatric Association, 2000, DIAGN CRIT DSM 4 TR Anderson JS, 2011, CEREB CORTEX, V21, P1134, DOI 10.1093/cercor/bhq190 Ashtari M, 2007, NEUROIMAGE, V35, P501, DOI 10.1016/j.neuroimage.2006.10.047 Badaruddin DH, 2007, CHILD PSYCHIAT HUM D, V38, P287, DOI 10.1007/s10578-007-0065-6 Barbas H, 2000, BRAIN RES BULL, V52, P319, DOI 10.1016/S0361-9230(99)00245-2 Barnea-Goraly N, 2005, CEREB CORTEX, V15, P1848, DOI 10.1093/cercor/bhi062 Barnea-Goraly N, 2010, ARCH GEN PSYCHIAT, V67, P1052, DOI 10.1001/archgenpsychiatry.2010.123 Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022 Basser PJ, 1996, J MAGN RESON SER B, V111, P209, DOI 10.1006/jmrb.1996.0086 Basser PJ, 2002, NMR BIOMED, V15, P456, DOI 10.1002/nbm.783 BASSER PJ, 1994, BIOPHYS J, V66, P259 Bava S, 2010, BRAIN RES, V1327, P38, DOI 10.1016/j.brainres.2010.02.066 Beacher FD, 2011, AM J NEURORADIOL, V33, P83, DOI DOI 10.3174/AJNR.A2880 BERLUCCHI G, 1995, NEUROPSYCHOLOGIA, V33, P923, DOI 10.1016/0028-3932(95)00031-W Bigler ED, 2007, DEV NEUROPSYCHOL, V31, P217 Bloemen OJN, 2010, AUTISM RES, V3, P203, DOI 10.1002/aur.146 Blomgren M, 2003, J FLUENCY DISORD, V28, P337, DOI 10.1016/j.jfludis.2003.08.002 Bloss CS, 2007, J AM ACAD CHILD PSY, V46, P515, DOI 10.1097/chi.0b013e318030e28b Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016 Boddaert N, 2003, AM J PSYCHIAT, V160, P2057, DOI 10.1176/appi.ajp.160.11.2057 Bode MK, 2011, ACTA RADIOL, V52, P1169, DOI 10.1258/ar.2011.110197 Bosnell RA, 2011, NEUROREHAB NEURAL RE, V25, P607, DOI 10.1177/1545968311405675 Brain Development Cooperative Group, 2011, CEREBRAL CORTEX NEW, V22, P1, DOI DOI 10.1093/CERCOR/BHR018 Brito AR, 2009, J NEUROIMAGING, V19, P337, DOI 10.1111/j.1552-6569.2009.00366.x Brown LN, 2000, J CLIN EXP NEUROPSYC, V22, P587, DOI 10.1076/1380-3395(200010)22:5;1-9;FT587 Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099 Casanova MF, 2002, J CHILD NEUROL, V17, P515, DOI 10.1177/088307380201700708 Casanova MF, 2009, PHILOS T R SOC B, V364, P1433, DOI 10.1098/rstb.2008.0331 Casanova MF, 2002, J CHILD NEUROL, V17, P692, DOI 10.1177/088307380201700908 Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5 Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189 Catani M, 2005, ANN NEUROL, V57, P8, DOI 10.1002/ana.20319 Catani M, 2007, P NATL ACAD SCI USA, V104, P17163, DOI 10.1073/pnas.0702116104 Catani M, 2008, CORTEX, V44, P1105, DOI 10.1016/j.cortex.2008.05.004 Catani M, 2008, NEUROIMAGE, V41, P1184, DOI 10.1016/j.neuroimage.2008.03.041 Cheng YW, 2010, NEUROIMAGE, V50, P873, DOI 10.1016/j.neuroimage.2010.01.011 Cheon KA, 2011, BRAIN RES, V1417, P77, DOI 10.1016/j.brainres.2011.08.020 Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c Cheung C, 2009, J CHILD PSYCHOL PSYC, V50, P1102, DOI 10.1111/j.1469-7610.2009.02086.x CHIRON C, 1995, DEV MED CHILD NEUROL, V37, P849 Conturo TE, 1999, P NATL ACAD SCI USA, V96, P10422, DOI 10.1073/pnas.96.18.10422 Conturo TE, 2008, J INT NEUROPSYCH SOC, V14, P933, DOI 10.1017/S1355617708081381 Courchesne E, 2001, NEUROLOGY, V57, P245 Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337 Courchesne E, 2011, JAMA-J AM MED ASSOC, V306, P2001, DOI 10.1001/jama.2011.1638 DAVID AS, 1993, J NEUROL NEUROSUR PS, V56, P85, DOI 10.1136/jnnp.56.1.85 Dawson G, 2007, BIOL PSYCHIAT, V61, P458, DOI 10.1016/j.biopsych.2006.07.016 Dementieva YA, 2005, PEDIATR NEUROL, V32, P102, DOI 10.1016/j.pediatrneurol.2004.08.005 Doherty D, 2006, CHILD CARE HLTH DEV, V32, P333, DOI 10.1111/j.1365-2214.2006.00602.x Elder LM, 2008, J AUTISM DEV DISORD, V38, P1104, DOI 10.1007/s10803-007-0495-9 Eliassen JC, 2000, BRAIN, V123, P2501, DOI 10.1093/brain/123.12.2501 Engvig A, 2011, HUM BRAIN MAPP, DOI [10.1002/hbm.21370, DOI 10.1002/HBM.21370] Flagg EJ, 2005, NEUROSCI LETT, V386, P82, DOI 10.1016/j.neulet.2005.05.037 Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083 Fukumoto A, 2008, J AUTISM DEV DISORD, V38, P411, DOI 10.1007/s10803-007-0405-1 Giorgio A, 2010, NEUROIMAGE, V51, P943, DOI 10.1016/j.neuroimage.2010.03.004 Giorgio A, 2008, NEUROIMAGE, V39, P52, DOI 10.1016/j.neuroimage.2007.07.043 Gordon EM, 2011, DEVELOPMENTAL SCI, V14, P738, DOI 10.1111/j.1467-7687.2010.01020.x Greicius MD, 2009, CEREB CORTEX, V19, P72, DOI 10.1093/cercor/bhn059 Groen WB, 2011, J PSYCHIATR NEUROSCI, V36, P32, DOI 10.1503/jpn.090100 Hale TS, 2010, NEUROPSYCHOLOGIA, V48, P3532, DOI 10.1016/j.neuropsychologia.2010.08.002 Hardan AY, 2000, NEUROLOGY, V55, P1033 Harsan LA, 2006, J NEUROSCI RES, V83, P392, DOI 10.1002/jnr.20742 Hasan KM, 2009, BRAIN RES, V1276, P67, DOI 10.1016/j.brainres.2009.04.025 Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366 Hofer S, 2008, CEREB CORTEX, V18, P1079, DOI 10.1093/cercor/bhm141 Hong SS, 2011, PSYCHIAT RES-NEUROIM, V194, P333, DOI 10.1016/j.pscychresns.2011.03.009 Ingalhalikar M, 2011, NEUROIMAGE, V57, P918, DOI 10.1016/j.neuroimage.2011.05.023 Jeong JW, 2011, AM J NEURORADIOL, V32, P1600, DOI 10.3174/ajnr.A2557 Jones DK, 1999, MAGNET RESON MED, V42, P37, DOI 10.1002/(SICI)1522-2594(199907)42:1<37::AID-MRM7>3.0.CO;2-O Jorgens S, 2007, NEUROREPORT, V18, P1339 Jou RJ, 2011, AUST NZ J PSYCHIAT, V45, P153, DOI 10.3109/00048674.2010.534069 Jou RJ, 2011, AM J NEURORADIOL, V32, P1607, DOI 10.3174/ajnr.A2558 Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Kana RK, 2009, SOC NEUROSCI-UK, V4, P135, DOI 10.1080/17470910802198510 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Kanner L, 1943, NERV CHILD, V2, P217 Ke XY, 2009, BRAIN RES, V1265, P171, DOI 10.1016/j.brainres.2009.02.013 Keary CJ, 2009, J AUTISM DEV DISORD, V39, P834, DOI 10.1007/s10803-009-0689-4 Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99 Keller TA, 2009, NEURON, V64, P624, DOI 10.1016/j.neuron.2009.10.018 Keune PM, 2011, BIOL PSYCHOL, V87, P306, DOI 10.1016/j.biopsycho.2011.02.023 Kilian S, 2008, DEV NEUROPSYCHOL, V33, P74, DOI 10.1080/87565640701729821 Knaus TA, 2010, BRAIN LANG, V112, P113, DOI 10.1016/j.bandl.2009.11.005 Koldewyn K, 2011, DEVELOPMENTAL SCI, V14, P1075, DOI 10.1111/j.1467-7687.2011.01058.x Kontis D, 2009, NEUROREPORT, V20, P424, DOI 10.1097/WNR.0b013e328325a8f9 Ben Bashat Dafna, 2007, Neuroimage, V37, P40, DOI 10.1016/j.neuroimage.2007.04.060 Kubicki M, 2002, AM J PSYCHIAT, V159, P813, DOI 10.1176/appi.ajp.159.5.813 Kumar A, 2010, CEREB CORTEX, V20, P2103, DOI 10.1093/cercor/bhp278 LACEY DJ, 1985, AM J DIS CHILD, V139, P953 Lainhart J. E., 2011, AUT SPECTR DIS, P477 Lainhart JE, 2011, JAMA-J AM MED ASSOC, V306, P2031, DOI 10.1001/jama.2011.1633 Lainhart JE, 1997, J AM ACAD CHILD PSY, V36, P282, DOI 10.1097/00004583-199702000-00019 Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465 Lange N, 2010, AUTISM RES, V3, P350, DOI 10.1002/aur.162 Langen M, 2012, CORTEX, V48, P183, DOI 10.1016/j.cortex.2011.05.018 Lebel C, 2011, J NEUROSCI, V31, P10937, DOI 10.1523/JNEUROSCI.5302-10.2011 Lebel C, 2008, NEUROIMAGE, V40, P1044, DOI 10.1016/j.neuroimage.2007.12.053 Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042 Lee JE, 2009, NEUROIMAGE, V44, P870, DOI 10.1016/j.neuroimage.2008.09.041 Levine B, 1998, BRAIN, V121, P1951, DOI 10.1093/brain/121.10.1951 Levitt JG, 2003, CEREB CORTEX, V13, P728, DOI 10.1093/cercor/13.7.728 Lo YC, 2011, PSYCHIAT RES-NEUROIM, V192, P60, DOI 10.1016/j.pscychresns.2010.09.008 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lovden M, 2010, NEUROPSYCHOLOGIA, V48, P3878, DOI 10.1016/j.neuropsychologia.2010.08.026 MCMAHAN CA, 1981, BIOMETRICS, V37, P447, DOI 10.2307/2530558 Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303 Minshew NJ, 2002, MOL PSYCHIATR, V7, pS14, DOI 10.1038/sj.mp.4001166 Mori S, 2002, MAGNET RESON MED, V47, P215, DOI 10.1002/mrm.10074 Mori S, 1999, ANN NEUROL, V45, P265, DOI 10.1002/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3 Moseley M, 2002, BRAIN COGNITION, V50, P396, DOI 10.1016/S0278-2626(02)00524-9 Muetzel RL, 2008, NEUROIMAGE, V39, P1918, DOI 10.1016/j.neuroimage.2007.10.018 Nordahl CW, 2011, P NATL ACAD SCI USA, V108, P20195, DOI 10.1073/pnas.1107560108 Noriuchi M, 2010, BRAIN RES, V1362, P141, DOI 10.1016/j.brainres.2010.09.051 Papagno C, 2011, CURR NEUROL NEUROSCI, V11, P553, DOI 10.1007/s11910-011-0219-6 Papagno C, 2011, BRAIN, V134, P405, DOI 10.1093/brain/awq283 Pardini M, 2009, EUR J NEUROL, V16, P1185, DOI 10.1111/j.1468-1331.2009.02699.x Pardini M, 2012, J AUTISM DEV DISORD, V42, P585, DOI 10.1007/s10803-011-1281-2 Paus T, 1999, SCIENCE, V283, P1908, DOI 10.1126/science.283.5409.1908 Pecini C, 2005, CORTEX, V41, P157, DOI 10.1016/S0010-9452(08)70890-6 Pierpaoli C, 1996, MAGNET RESON MED, V36, P893, DOI 10.1002/mrm.1910360612 Poustka L, 2012, WORLD J BIOL PSYCHIA, V13, P269, DOI 10.3109/15622975.2011.591824 Pugliese L, 2009, NEUROIMAGE, V47, P427, DOI 10.1016/j.neuroimage.2009.05.014 Reiss AL, 1996, BRAIN, V119, P1763, DOI 10.1093/brain/119.5.1763 Sahyoun CP, 2010, BRAIN COGNITION, V73, P180, DOI 10.1016/j.bandc.2010.05.002 Sahyoun CP, 2010, NEUROPSYCHOLOGIA, V48, P86, DOI 10.1016/j.neuropsychologia.2009.08.013 Scheel C, 2011, NEUROIMAGE, V58, P391, DOI 10.1016/j.neuroimage.2011.06.040 Schipul SE, 2011, FRONTIERS SYSTEMS NE, V5, P1, DOI DOI 10.3389/FNSYS.2011.00010 SCHLAUG G, 1995, NEUROPSYCHOLOGIA, V33, P1047, DOI 10.1016/0028-3932(95)00045-5 Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010 Shih P, 2011, BIOL PSYCHIAT, V70, P270, DOI 10.1016/j.biopsych.2011.03.040 Shukla DK, 2011, NEUROPSYCHOLOGIA, V49, P1378, DOI 10.1016/j.neuropsychologia.2011.02.022 Shukla DK, 2010, J AM ACAD CHILD PSY, V49, P1269, DOI 10.1016/j.jaac.2010.08.018 Shukla DK, 2011, J CHILD PSYCHOL PSYC, V52, P286, DOI 10.1111/j.1469-7610.2010.02342.x Sivaswamy L, 2010, J CHILD NEUROL, V25, P1223, DOI 10.1177/0883073809358765 Smith SM, 2006, NEUROIMAGE, V31, P1487, DOI 10.1016/j.neuroimage.2006.02.024 Sommer I, 2001, BRIT J PSYCHIAT, V178, P344, DOI 10.1192/bjp.178.4.344 Song SK, 2002, NEUROIMAGE, V17, P1429, DOI 10.1006/nimg.2002.1267 Song SK, 2005, NEUROIMAGE, V26, P132, DOI 10.1016/j.neuroimage.2005.01.028 Sparks BF, 2002, NEUROLOGY, V59, P184 Sundaram SK, 2008, CEREB CORTEX, V18, P2659, DOI 10.1093/cercor/bhn031 Supekar K, 2010, NEUROIMAGE, V52, P290, DOI 10.1016/j.neuroimage.2010.04.009 Takeuchi H, 2010, J NEUROSCI, V30, P3297, DOI 10.1523/JNEUROSCI.4611-09.2010 Tan GCY, 2010, NEUROIMAGE, V53, P1030, DOI 10.1016/j.neuroimage.2010.02.018 Taubert M, 2010, J NEUROSCI, V30, P11670, DOI 10.1523/JNEUROSCI.2567-10.2010 Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099 Thomas C, 2011, CORTEX, V47, P863, DOI 10.1016/j.cortex.2010.07.006 Tournier JD, 2011, MAGN RESON MED, V65, P1532, DOI 10.1002/mrm.22924 Tyszka JM, 2006, NEUROIMAGE, V29, P1058, DOI 10.1016/j.neuroimage.2005.08.037 Tzourio N, 1998, NEUROIMAGE, V8, P1, DOI 10.1006/nimg.1998.0343 van den Heuvel MP, 2009, HUM BRAIN MAPP, V30, P3127, DOI 10.1002/hbm.20737 Verhoeven JS, 2012, CEREB CORTEX, V22, P2263, DOI 10.1093/cercor/bhr292 Vidal CN, 2006, BIOL PSYCHIAT, V60, P218, DOI 10.1016/j.biopsych.2005.11.011 Wedeen VJ, 2008, NEUROIMAGE, V41, P1267, DOI 10.1016/j.neuroimage.2008.03.036 Wehner DT, 2007, NEUROPSYCHOLOGIA, V45, P3251, DOI 10.1016/j.neuropsychologia.2007.06.018 Weinstein M, 2011, HUM BRAIN MAPP, V32, P534, DOI 10.1002/hbm.21042 Wheeler-Kingshott CAM, 2009, MAGN RESON MED, V61, P1255, DOI 10.1002/mrm.21965 Williams DL, 2006, CHILD NEUROPSYCHOL, V12, P279, DOI 10.1080/09297040600681190 Wolff JJ, 2012, AM J PSYCHIAT, V169, P589, DOI 10.1176/appi.ajp.2011.11091447 Yakovlev P. I., 1967, REGIONAL DEV BRAIN E, P3 Zahr NM, 2009, NEUROIMAGE, V44, P1050, DOI 10.1016/j.neuroimage.2008.09.046 Zhang H, 2007, IEEE T MED IMAGING, V26, P1585, DOI 10.1109/TMI.2007.906784 NR 171 TC 61 Z9 64 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2012 VL 5 IS 5 BP 289 EP 313 DI 10.1002/aur.1243 PG 25 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 023WI UT WOS:000310067300001 PM 22786754 ER PT J AU McGrath, J Johnson, K Ecker, C O'Hanlon, E Gill, M Gallagher, L Garavan, H AF McGrath, Jane Johnson, Katherine Ecker, Christine O'Hanlon, Erik Gill, Michael Gallagher, Louise Garavan, Hugh TI Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis SO AUTISM RESEARCH LA English DT Review DE autism; functional MRI; visuospatial processing; mental rotation; functional connectivity ID EMBEDDED FIGURES TASK; TIME-RESOLVED FMRI; MENTAL ROTATION; SPECTRUM DISORDERS; EXECUTIVE FUNCTION; VISUAL-SEARCH; CORTICAL UNDERCONNECTIVITY; SENTENCE COMPREHENSION; ASPERGERS-DISORDER; WORKING-MEMORY AB Atypical visuospatial processing is commonly described in autism spectrum disorders (ASDs); however the specific neurobiological underpinnings of this phenomenon are poorly understood. Given the extensive evidence suggesting ASDs are characterized by abnormal neural connectivity, this study aimed to investigate network connectivity during visuospatial processing in ASD. Twenty-two males with ASD without intellectual disability and 22 individually matched controls performed a mental rotation task during functional magnetic resonance imaging (MRI) in which two rotated stimuli were judged to be same (Same Trials) or mirror-imaged (Mirror Trials). Behavioral results revealed a relative advantage of mental rotation in the ASD groupcontrols were slower responding to the more difficult Mirror Trials than Same Trials whereas the ASD group completed Mirror Trials and Same-trials at similar speeds. In the ASD group, brain activity was reduced in frontal, temporal, occipital, striatal, and cerebellar regions and, consistent with previous literature, functional connectivity between a number of brain regions was reduced. However, some connections appeared to be conserved and were recruited in a qualitatively different way by the two groups. As task difficulty increased (on Mirror Trials), controls tended to increase connections between certain brain regions, whereas the ASD group appeared to suppress connections between these regions. There was an interesting exception to this pattern in the visual cortex, a finding that may suggest an advantage in early visual perceptual processing in ASD. Overall, this study has identified a relative advantage in mental rotation in ASD that is associated with aberrant neural connectivity and that may stem from enhanced visual perceptual processing. Autism Res 2012, 5: 314330. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [McGrath, Jane; Johnson, Katherine; Gill, Michael; Gallagher, Louise] St James Hosp, Trinity Ctr Hlth Sci, Dept Psychiat, Dublin 8, Ireland. [Johnson, Katherine] Univ Melbourne, Parkville, Vic 3052, Australia. [Ecker, Christine] Inst Psychiat, Dept Forens & Neurodev Sci, London, England. [O'Hanlon, Erik] Beaumont Hosp, Royal Coll Surg Ireland, Dept Psychiat, Dublin 9, Ireland. [Garavan, Hugh] Univ Dublin Trinity Coll, Sch Psychol, Dublin 2, Ireland. [Garavan, Hugh] Univ Dublin Trinity Coll, Inst Neurosci, Dublin 2, Ireland. [Garavan, Hugh] Univ Vermont, Dept Psychiat, Burlington, VT USA. [Garavan, Hugh] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA. RP McGrath, J (reprint author), St James Hosp, Trinity Ctr Hlth Sci, Dept Psychiat, Dublin 8, Ireland. EM jane.mcgrath@tcd.ie RI Ecker, Christine/E-5194-2010 FU Molecular Medicine Ireland [4AA-G04005-S06] FX Grant sponsor: Molecular Medicine IrelandGrant number: 4AA-G04005-S06 CR Barttfeld P, 2011, NEUROPSYCHOLOGIA, V49, P254, DOI 10.1016/j.neuropsychologia.2010.11.024 Belmonte MK, 2003, COGNITIVE BRAIN RES, V17, P651, DOI 10.1016/S0926-6410(03)00189-7 Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561 Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003 Caron MJ, 2004, NEUROPSYCHOLOGIA, V42, P467, DOI 10.1016/j.neuropsychologia.2003.08.015 Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072 Casanova MF, 2002, NEUROLOGY, V58, P428 Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5 Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c Cox RW, 1996, COMPUT BIOMED RES, V29, P162, DOI 10.1006/cbmr.1996.0014 Damarla SR, 2010, AUTISM RES, V3, P273, DOI 10.1002/aur.153 Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x Ecker C, 2008, J COGNITIVE NEUROSCI, V20, P1003, DOI 10.1162/jocn.2008.20063 Ecker C, 2006, NEUROIMAGE, V32, P432, DOI 10.1016/j.neuroimage.2006.03.031 Falter CM, 2008, J AUTISM DEV DISORD, V38, P507, DOI 10.1007/s10803-007-0419-8 Friston KJ, 1997, NEUROIMAGE, V6, P218, DOI 10.1006/nimg.1997.0291 Grill-Spector K, 2004, ANNU REV NEUROSCI, V27, P649, DOI 10.1146/annurev.neuro.27.070203.144220 Perreault A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019519 Hamilton AFD, 2009, COGNITION, V113, P37, DOI 10.1016/j.cognition.2009.07.007 Hamm JP, 2004, NEUROPSYCHOLOGIA, V42, P810, DOI 10.1016/j.neuropsychologia.2003.11.009 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Hayashi M, 2008, BRAIN COGNITION, V66, P306, DOI 10.1016/j.bandc.2007.09.008 Hughes C., 1993, DEV PSYCHOL, V29, P298 Hussman JP, 2001, J AUTISM DEV DISORD, V31, P247, DOI 10.1023/A:1010715619091 Hutsler JJ, 2010, BRAIN RES, V1309, P83, DOI 10.1016/j.brainres.2009.09.120 Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004 Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054 Koshino H, 2005, COGN AFFECT BEHAV NE, V5, P54, DOI 10.3758/CABN.5.1.54 Kuschner ES, 2009, AUTISM RES, V2, P348, DOI 10.1002/aur.101 Lee PS, 2007, NEUROIMAGE, V38, P184, DOI 10.1016/j.neuroimage.2007.07.013 Liu YN, 2011, NEUROPSYCHOLOGIA, V49, P2105, DOI 10.1016/j.neuropsychologia.2011.04.005 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Manjaly ZM, 2007, NEUROIMAGE, V35, P283, DOI 10.1016/j.neuroimage.2006.11.036 Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Mottron L, 2009, PHILOS T R SOC B, V364, P1385, DOI 10.1098/rstb.2008.0333 Mourao-Miranda J, 2009, J COGNITIVE NEUROSCI, V21, P890, DOI 10.1162/jocn.2009.21078 Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012 Noonan SK, 2009, BRAIN RES, V1262, P48, DOI 10.1016/j.brainres.2008.12.076 O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719 Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110 Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003 Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P765, DOI 10.1017/S0021963098002601 Pruessmann KP, 1999, MAGNET RESON MED, V42, P952, DOI 10.1002/(SICI)1522-2594(199911)42:5<952::AID-MRM16>3.3.CO;2-J Richter W, 1997, NEUROREPORT, V8, P3697, DOI 10.1097/00001756-199712010-00008 Rinehart NJ, 2006, AUTISM, V10, P70, DOI 10.1177/1362361306062011 Sahyoun CP, 2010, BRAIN COGNITION, V73, P180, DOI 10.1016/j.bandc.2010.05.002 Sattler J. M., 1992, ASSESSEMENT CHILDREN Schipul Sarah E, 2011, Front Syst Neurosci, V5, P10, DOI 10.3389/fnsys.2011.00010 Schmitz N, 2006, BIOL PSYCHIAT, V59, P7, DOI 10.1016/j.biopsych.2005.06.007 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x SHEPARD RN, 1971, SCIENCE, V171, P701, DOI 10.1126/science.171.3972.701 Silk TJ, 2006, AM J PSYCHIAT, V163, P1440, DOI 10.1176/appi.ajp.163.8.1440 Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019 Soulieres I, 2011, NEUROPSYCHOLOGIA, V49, P848, DOI 10.1016/j.neuropsychologia.2011.01.027 Steele SD, 2007, J AUTISM DEV DISORD, V37, P605, DOI 10.1007/s10803-006-0202-2 Talairach J., 1988, COPLANAR STEREOTAXIC Townsend J, 1999, J NEUROSCI, V19, P5632 Vandenbroucke MWG, 2008, BRAIN, V131, P1013, DOI 10.1093/brain/awm321 Verte S, 2005, DEV PSYCHOPATHOL, V17, P415, DOI 10.1017/S0954579405050200 Wass S, 2011, BRAIN COGNITION, V75, P18, DOI 10.1016/j.bandc.2010.10.005 Wechsler D., 2004, WECHSLER INTELLIGENC Wechsler D., 1997, WAIS 3 ADM SCORING M Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057 Zacks J.M., 2007, J COGNITIVE NEUROSCI, V20, P1 NR 73 TC 7 Z9 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2012 VL 5 IS 5 BP 314 EP 330 DI 10.1002/aur.1245 PG 17 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 023WI UT WOS:000310067300002 PM 22865697 ER PT J AU Sheinkopf, SJ Iverson, JM Rinaldi, ML Lester, BM AF Sheinkopf, Stephen J. Iverson, Jana M. Rinaldi, Melissa L. Lester, Barry M. TI Atypical Cry Acoustics in 6-Month-Old Infants at Risk for Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE autism; infancy; cry; vocalizations; acoustic analysis ID NEWBORN-INFANTS; EARLY IDENTIFICATION; 1ST YEAR; CHILDREN; COMMUNICATION; EXPOSURE; PRETERM; LIFE; TERM; CIRCUMCISION AB This study examined differences in acoustic characteristics of infant cries in a sample of babies at risk for autism and a low-risk comparison group. Cry samples derived from vocal recordings of 6-month-old infants at risk for autism spectrum disorder (ASD; n?=?21) and low-risk infants (n?=?18) were subjected to acoustic analyses using analysis software designed for this purpose. Cries were categorized as either pain-related or non-pain-related based on videotape coding. At-risk infants produced pain-related cries with higher and more variable fundamental frequency (F 0) than low-risk infants. At-risk infants later classified with ASD at 36 months had among the highest F 0 values for both types of cries and produced cries that were more poorly phonated than those of nonautistic infants, reflecting cries that were less likely to be produced in a voiced mode. These results provide preliminary evidence that disruptions in cry acoustics may be part of an atypical vocal signature of autism in early life. Autism Res 2012, : . (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Sheinkopf, Stephen J.; Lester, Barry M.] Brown Univ, Women & Infants Hosp, Brown Alpert Med Sch, Ctr Study Children Risk,Dept Psychiat & Human Beh, Providence, RI 02905 USA. [Sheinkopf, Stephen J.; Lester, Barry M.] Brown Univ, Women & Infants Hosp, Brown Alpert Med Sch, Ctr Study Children Risk,Dept Pediat, Providence, RI 02905 USA. [Iverson, Jana M.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA. [Rinaldi, Melissa L.] EP Bradley Hosp, Brown Alpert Med Sch, Ctr Autism & Dev Disabil, Dept Psychiat & Human Behav, E Providence, RI USA. RP Sheinkopf, SJ (reprint author), Brown Univ, Women & Infants Hosp, Brown Ctr Children, 101 Dudley St, Providence, RI 02905 USA. EM Stephen_Sheinkopf@brown.edu FU Autism Speaks; NICHD [R01-HD41677, R01-HD54979, R03-DC009301] FX This study was supported by Autism Speaks and by NICHD; R01-HD41677, R01-HD54979, and NIDCD; R03-DC009301. CR Branco A, 2007, INT J PEDIATR OTORHI, V71, P539, DOI 10.1016/j.ijporl.2006.11.009 Cassel TD, 2007, J AUTISM DEV DISORD, V37, P122, DOI 10.1007/s10803-006-0337-1 CORWIN MJ, 1995, PEDIATRICS, V96, P73 CORWIN MJ, 1992, PEDIATRICS, V89, P1199 Esposito G, 2009, FOCUS AUTISM DEV DIS, V24, P240, DOI 10.1177/1088357609336449 Esposito G., 2010, EARLY CHILD DEV CARE, V180, P1093, DOI DOI 10.1080/03004430902775633 Gibbins S, 2008, EARLY HUM DEV, V84, P731, DOI 10.1016/j.earlhumdev.2008.05.004 Goberman AM, 1999, J SPEECH LANG HEAR R, V42, P850 Grauel E. L., 1990, EARLY CHILD DEV CARE, V65, P23, DOI 10.1080/0300443900650104 KARELITZ S, 1962, J PEDIATR-US, V61, P679, DOI 10.1016/S0022-3476(62)80338-2 LaGasse LL, 2005, MENT RETARD DEV D R, V11, P83, DOI 10.1002/mrdd.20050 Lehr VT, 2007, CLIN J PAIN, V23, P417, DOI 10.1097/AJP.0b013e31805476f2 Lester B M, 1984, ADV INFANCY RES, P167 LESTER BM, 1991, CHILD DEV, V62, P694, DOI 10.1111/j.1467-8624.1991.tb01563.x LESTER BM, 1987, PEDIATRICS, V80, P529 Lester BM, 2002, PEDIATRICS, V110, P1182, DOI 10.1542/peds.110.6.1182 Lin HC, 2007, INFANCY, V11, P175 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Mampe B, 2009, CURR BIOL, V19, P1994, DOI 10.1016/j.cub.2009.09.064 Merin N, 2007, J AUTISM DEV DISORD, V37, P108, DOI 10.1007/s10803-006-0342-4 Michelsson K, 2002, FOLIA PHONIATR LOGO, V54, P190, DOI 10.1159/000063190 Mullen E, 1995, MULLEN SCALES EARLY Newman JD, 2007, BEHAV BRAIN RES, V182, P155, DOI 10.1016/j.bbr.2007.02 Oller D. K., 2010, P NATL ACAD SCI USA, V107, p[354, 359] Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009 Paul R., 2010, J CHILD PSYCHOL PSYC, V52, P588 PORTER FL, 1988, CHILD DEV, V59, P495, DOI 10.1111/j.1467-8624.1988.tb01483.x PRECHTL HFR, 1969, DEV MED CHILD NEUROL, V11, P142 Quick ZL, 2009, ACTA PAEDIATR, V98, P74, DOI 10.1111/j.1651-2227.2008.01011.x RICKS DM, 1975, J AUTISM CHILD SCHIZ, V5, P191, DOI 10.1007/BF01538152 Rothganger H, 2003, EARLY HUM DEV, V75, P55, DOI 10.1016/j.earlhumdev.2003.09.003 Schoen E, 2011, AUTISM RES, V4, P177, DOI 10.1002/aur.183 Sheinkopf SJ, 2000, J AUTISM DEV DISORD, V30, P345, DOI 10.1023/A:1005531501155 Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335 Wasz-Hockert O., 1968, INFANT CRY, V29 Wermke K, 2002, MED ENG PHYS, V24, P501, DOI 10.1016/S1350-4533(02)00061-9 WETHERBY AM, 1989, J SPEECH HEAR DISORD, V54, P148 Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y Woods JJ, 2003, LANG SPEECH HEAR SER, V34, P180, DOI 10.1044/0161-1461(2003/015) Yirmiya N, 2006, J CHILD PSYCHOL PSYC, V47, P511, DOI 10.1111/j.1469-7610.2005.01528.x ZESKIND PS, 1993, DEV PSYCHOBIOL, V26, P321, DOI 10.1002/dev.420260603 Zeskind PS, 1996, INFANT BEHAV DEV, V19, P497, DOI 10.1016/S0163-6383(96)90009-0 Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001 NR 43 TC 11 Z9 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2012 VL 5 IS 5 BP 331 EP 339 DI 10.1002/aur.1244 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 023WI UT WOS:000310067300003 PM 22890558 ER PT J AU Marco, EJ Khatibi, K Hill, SS Siegel, B Arroyo, MS Dowling, AF Neuhaus, JM Sherr, EH Hinkley, LNB Nagarajan, SS AF Marco, Elysa J. Khatibi, Kasra Hill, Susanna S. Siegel, Bryna Arroyo, Monica S. Dowling, Anne F. Neuhaus, John M. Sherr, Elliott H. Hinkley, Leighton N. B. Nagarajan, Srikantan S. TI Children With Autism Show Reduced Somatosensory Response: An MEG Study SO AUTISM RESEARCH LA English DT Article DE cognitive neuroscience; event related potential; school age; low-level perception; magnetoencephalography ID TACTILE SENSITIVITY; EVOKED-POTENTIALS; SENSORY PROFILE; ABNORMALITIES; DISORDER; BRAINS; CORTEX; ADULTS; MODEL AB The neural underpinnings of sensory processing differences in autism remain poorly understood. This prospective magnetoencephalography (MEG) study investigates whether children with autism show atypical cortical activity in the primary somatosensory cortex (S1) in comparison with matched controls. Tactile stimuli were clearly detectable, and painless taps were applied to the distal phalanx of the second (D2) and third (D3) fingers of the right and left hands. Three tactile paradigms were administered: an oddball paradigm (standard taps to D3 at an interstimulus interval (ISI) of 0.33 and deviant taps to D2 with ISI ranging from 1.32?s to 1.64?s); a slow-rate paradigm (D2) with an ISI matching the deviant taps in the oddball paradigm; and a fast-rate paradigm (D2) with an ISI matching the standard taps in the oddball. Study subjects were boys (age 711 years) with and without autism disorder. Sensory behavior was quantified using the Sensory Profile questionnaire. Boys with autism exhibited smaller amplitude left hemisphere S1 response to slow and deviant stimuli during the right-hand paradigms. In post-hoc analysis, tactile behavior directly correlated with the amplitude of cortical response. Consequently, the children were re-categorized by degree of parent-report tactile sensitivity. This regrouping created a more robust distinction between the groups with amplitude diminution in the left and right hemispheres and latency prolongation in the right hemisphere in the deviant and slow-rate paradigms for the affected children. This study suggests that children with autism have early differences in somatosensory processing, which likely influence later stages of cortical activity from integration to motor response. Autism Res 2012, 5: 340351. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Marco, Elysa J.] Univ Calif San Francisco, Div Child Neurol, Dept Neurol Pediat & Psychiat, San Francisco, CA 94143 USA. [Khatibi, Kasra; Hill, Susanna S.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA. [Siegel, Bryna; Arroyo, Monica S.] Univ Calif San Francisco, Langley Porter Psychiat Inst, Dept Psychiat, San Francisco, CA USA. [Dowling, Anne F.; Hinkley, Leighton N. B.; Nagarajan, Srikantan S.] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA. [Neuhaus, John M.] Univ Calif San Francisco, Dept Biostat, San Francisco, CA 94143 USA. [Sherr, Elliott H.] Univ Calif San Francisco, Dept Neurol & Pediat, San Francisco, CA 94143 USA. RP Marco, EJ (reprint author), Univ Calif San Francisco, Div Child Neurol, Dept Neurol Pediat & Psychiat, 350 Parnassus Ave,Ste 609, San Francisco, CA 94143 USA. EM marcoe@neuropeds.ucsf.edu FU National Institutes of Health [NSADA K12 NS01692-07, NIH-K23MH083890, NCRR UCSF-CTSI UL1 RR024131, RO1DC4855, RO1DC6435, R01NS066654, R01NS64060]; Cure Autism Now; Wallace Research Foundation FX We appreciate the time and dedication of the children and their families who participated in this research. We thank John Rubenstein and Heidi Kirsch for their helpful comments, and Susanne Honma for her assistance with MEG data acquisition. This work was supported by the National Institutes of Health (E.J.M.: NSADA K12 NS01692-07, NIH-K23MH083890, NCRR UCSF-CTSI UL1 RR024131 and S.S.N.: RO1DC4855, RO1DC6435, R01NS066654, and R01NS64060), Cure Autism Now (grant to SSN), and the Wallace Research Foundation (Grant to EJM). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH, and these funding organizations had no involvement in design, collection, analysis, or manuscript preparation or publication decisions. The authors have no conflicts of interest to declare. CR Akatsuka K, 2007, CLIN NEUROPHYSIOL, V118, P403, DOI 10.1016/j.clinph.2006.09.030 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709 Bader PL, 2011, P NATL ACAD SCI USA, V108, P15432, DOI 10.1073/pnas.1112667108 Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3 Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013 Casanova MF, 2002, J CHILD NEUROL, V17, P692, DOI 10.1177/088307380201700908 Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552 Cascio C, 2008, J AUTISM DEV DISORD, V38, P127, DOI 10.1007/s10803-007-0370-8 Coskun MA, 2009, NEUROREPORT, V20, P175, DOI 10.1097/WNR.0b013e32831f47d1 Dane S, 2007, INT J DEV NEUROSCI, V25, P223, DOI 10.1016/j.ijdevneu.2007.03.005 Daw MI, 2007, NAT NEUROSCI, V10, P453, DOI 10.1038/nn1866 DeLorey T. M., 2010, BEHAV BRAIN RES, V216, P36, DOI [S0166-4328(10)00476-6[pii]10.1016/j.bbr.2010.06.032, DOI 10.1016/J.BBR.2010.06] Dunn W, 1997, AM J OCCUP THER, V51, P25 Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933 Etherton M, 2011, P NATL ACAD SCI USA, V108, P13764, DOI 10.1073/pnas.1111093108 Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7 Guclu B, 2007, SOMATOSENS MOT RES, V24, P21, DOI 10.1080/08990220601179418 HASHIMOTO T, 1986, BRAIN DEV-JPN, V8, P428 Hull C, 2007, NAT NEUROSCI, V10, P400, DOI 10.1038/nn0407-400 KEMNER C, 1994, ELECTROEN CLIN NEURO, V92, P225, DOI 10.1016/0168-5597(94)90066-3 Leekam SR, 2007, J AUTISM DEV DISORD, V37, P894, DOI 10.1007/s10803-006-0218-7 Marco EJ, 2011, PEDIATR RES, V69, p48R, DOI [10.1203/PDR.0b013e3182130c54, 10.1109/SPL.2011.5782616] McCulloch C. E., 2008, GEN LINEAR MIXED MOD, V2nd Miyazaki M, 2007, DEV MED CHILD NEUROL, V49, P13, DOI 10.1017/S0012162207000059 Redcay E, 2008, BIOL PSYCHIAT, V64, P589, DOI 10.1016/j.biopsych.2008.05.020 Restuccia D, 2009, DEV MED CHILD NEUROL, V51, P991, DOI 10.1111/j.1469-8749.2009.03367.x Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Russo N, 2010, AUTISM RES, V3, P253, DOI 10.1002/aur.152 Rutter M., 2003, SOCIAL COMMUNICATION Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 Sokhadze E, 2009, APPL PSYCHOPHYS BIOF, V34, P37, DOI 10.1007/s10484-009-9074-5 Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011 Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 Tomchek SD, 2007, AM J OCCUP THER, V61, P190 Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd Wikstrom H, 1996, EVOKED POTENTIAL, V100, P479 Zhu Z, 2007, BMC NEUROSCI, V8, DOI 10.1186/1471-2202-8-21 NR 39 TC 5 Z9 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2012 VL 5 IS 5 BP 340 EP 351 DI 10.1002/aur.1247 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 023WI UT WOS:000310067300004 PM 22933354 ER PT J AU Linkenauger, SA Lerner, MD Ramenzoni, VC Proffitt, DR AF Linkenauger, Sally A. Lerner, Matthew D. Ramenzoni, Veronica C. Proffitt, Dennis R. TI A Perceptual-Motor Deficit Predicts Social and Communicative Impairments in Individuals With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; social deficits; perception; perceptual; motor integration; action capability estimation; affordance perception ID ATTENTION DEFICIT/HYPERACTIVITY DISORDER; BIOLOGICAL MOTION; PERCEIVING AFFORDANCES; SCALED INFORMATION; ASPERGERS SYNDROME; KINEMATIC ANALYSIS; VISUAL GUIDANCE; CHILDREN; MOVEMENTS; DISTANCE AB Individuals with autism spectrum disorders (ASDs) have known impairments in social and motor skills. Identifying putative underlying mechanisms of these impairments could lead to improved understanding of the etiology of core social/communicative deficits in ASDs, and identification of novel intervention targets. The ability to perceptually integrate one's physical capacities with one's environment (affordance perception) may be such a mechanism. This ability has been theorized to be impaired in ASDs, but this question has never been directly tested. Crucially, affordance perception has shown to be amenable to learning; thus, if it is implicated in deficits in ASDs, it may be a valuable unexplored intervention target. The present study compared affordance perception in adolescents and adults with ASDs to typically developing (TD) controls. Two groups of individuals (adolescents and adults) with ASDs and age-matched TD controls completed well-established action capability estimation tasks (reachability, graspability, and aperture passability). Their caregivers completed a measure of their lifetime social/communicative deficits. Compared with controls, individuals with ASDs showed unprecedented gross impairments in relating information about their bodies' action capabilities to visual information specifying the environment. The magnitude of these deficits strongly predicted the magnitude of social/communicative impairments in individuals with ASDs. Thus, social/communicative impairments in ASDs may derive, at least in part, from deficits in basic perceptualmotor processes (e.g. action capability estimation). Such deficits may impair the ability to maintain and calibrate the relationship between oneself and one's social and physical environments, and present fruitful, novel, and unexplored target for intervention. Autism Res 2012,5:352362. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Linkenauger, Sally A.] Max Planck Inst Biol Cybernet, Cognit & Computat Psychophys Dept, D-72012 Tubingen, Germany. [Lerner, Matthew D.; Proffitt, Dennis R.] Univ Virginia, Dept Psychol, Charlottesville, VA 22903 USA. [Ramenzoni, Veronica C.] Max Planck Inst Psycholinguist, Nijmegen, Netherlands. RP Linkenauger, SA (reprint author), Max Planck Inst Biol Cybernet, Cognit & Computat Psychophys Dept, Postfach 21 69, D-72012 Tubingen, Germany. EM sally.linkenauger@tuebingen.mpg.de RI Ramenzoni, Veronica/J-8632-2012 OI Ramenzoni, Veronica/0000-0003-3003-5012 FU Jefferson Scholars Foundation; National Institute of Health [RO1MH075781] FX Grant sponsor: Jefferson Scholars Foundation; Grant number: James H. and Elizabeth W. Wright Endowed Fellowship (Matthew D. Lerner).Grant sponsor: National Institute of Health; Grant number: RO1MH075781 (Dennis R. Proffitt). CR Adolph K. E., 2006, HDB CHILD PSYCHOL, V2, P161 Adolph K. E., 1997, MONOGR SOC RES CHILD, V62, DOI 10.2307/1166199 Ashwin E, 2009, BIOL PSYCHIAT, V65, P17, DOI 10.1016/j.biopsych.2008.06.012 Asperger H., 1994, ARCH PSYCHIAT NERVEN, V117, P132 Attwood T., 2008, COMPLETE GUIDE ASPER Baranek G. T., 2005, HDB AUTISM PERVASIVE, VII, P831 Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434 Blakemore SJ, 2001, NAT REV NEUROSCI, V2, P561 Block M.E., 1993, ADAPTED PHYS ACTIVIT, V10, P137 Boker SM, 2011, J EXP PSYCHOL HUMAN, V37, P874, DOI 10.1037/a0021928 Boria S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005596 Brindley R. M., 2007, NEUROPSYCHOLOGIA, V45, P1859, DOI [10.1016/j.neuropsychologia.2006.11.022, DOI 10.1016/J.NEUROPSYCHOLOGIA.2006.11.022] Carpenter M, 2001, J AUTISM DEV DISORD, V31, P589, DOI 10.1023/A:1013251112392 Chang CH, 2010, RES DEV DISABIL, V31, P1536, DOI 10.1016/j.ridd.2010.06.003 Chang CH, 2009, J MOTOR BEHAV, V41, P495, DOI 10.3200/35-08-095 Cook J, 2009, NEUROPSYCHOLOGIA, V47, P3275, DOI 10.1016/j.neuropsychologia.2009.07.010 Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x Davis TJ, 2010, PERCEPTION, V39, P1624, DOI 10.1068/p6712 de Marchena A, 2010, AUTISM RES, V3, P311, DOI 10.1002/aur.159 DEWEY D, 1992, DEV NEUROPSYCHOL, V8, P367 Dewey D, 1995, BRAIN COGNITION, V29, P254, DOI 10.1006/brcg.1995.1281 Dowell LR, 2009, NEUROPSYCHOLOGY, V23, P563, DOI 10.1037/a0015640 Fabbri-Destro M, 2008, PHYSIOLOGY, V23, P171, DOI 10.1152/physiol.00004.2008 Fajen BR, 2005, J EXP PSYCHOL HUMAN, V31, P1107, DOI 10.1037/0096-1523.31.5.1107 Falck-Ytter T, 2010, BIOL LETTERS, V6, P375, DOI 10.1098/rsbl.2009.0897 Forti S, 2011, RES AUTISM SPECT DIS, V5, P834, DOI 10.1016/j.rasd.2010.09.013 Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025 Gibson J. J., 1966, SENSES CONSIDERED PE Gibson J. J., 1979, ECOLOGICAL APPROACH Glazebrook CM, 2006, MOTOR CONTROL, V10, P244 Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356 HEFT H, 1993, ECOL PSYCHOL, V5, P255, DOI 10.1207/s15326969eco0503_3 Higuchi T, 2004, J EXP PSYCHOL-APPL, V10, P55, DOI 10.1037/1076-898X.10.1.55 Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y Ishak S, 2008, J EXP PSYCHOL HUMAN, V34, P1501, DOI 10.1037/a0011393 Johnson DC, 2007, DISABIL REHABIL, V29, P33, DOI 10.1080/09638280600947708 Kaiser MD, 2009, PSYCHON B REV, V16, P761, DOI 10.3758/PBR.16.5.761 Klimkeit EI, 2005, CHILD NEUROPSYCHOL, V11, P153, DOI 10.1080/092970790911298 Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868 Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202 Koldewyn K, 2011, DEVELOPMENTAL SCI, V14, P1075, DOI 10.1111/j.1467-7687.2011.01058.x KONCZAK J, 1992, J EXP PSYCHOL HUMAN, V18, P691, DOI 10.1037//0096-1523.18.3.691 Linkenauger SA, 2009, J EXP PSYCHOL HUMAN, V35, P1649, DOI 10.1037/a0016875 Lombardo MV, 2011, CONSCIOUS COGN, V20, P130, DOI 10.1016/j.concog.2010.09.006 Lord C., 1999, MANULA AUTISM DIAGNO MARK LS, 1987, J EXP PSYCHOL HUMAN, V13, P361, DOI 10.1037/0096-1523.13.3.361 MARK L S, 1990, Ecological Psychology, V2, P325, DOI 10.1207/s15326969eco0204_2 Marsh KL, 2009, TOP COGN SCI, V1, P320, DOI 10.1111/j.1756-8765.2009.01022.x McKay LS, 2012, NEUROIMAGE, V59, P1524, DOI 10.1016/j.neuroimage.2011.08.033 McPartland JC, 2011, SOC NEUROSCI-UK, V6, P436, DOI 10.1080/17470919.2011.586880 Ming X, 2007, BRAIN DEV-JPN, V29, P565, DOI 10.1016/j.braindev.2007.03.002 Moore DG, 1997, BRIT J DEV PSYCHOL, V15, P401 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Murphy P, 2009, NEUROPSYCHOLOGIA, V47, P3225, DOI 10.1016/j.neuropsychologia.2009.07.026 Nazarali N, 2009, J AUTISM DEV DISORD, V39, P1401, DOI 10.1007/s10803-009-0756-x Oudejans RRD, 1996, J EXP PSYCHOL HUMAN, V22, P879, DOI 10.1037/0096-1523.22.4.879 Parkinson J, 2011, Q J EXP PSYCHOL, V64, P1463, DOI 10.1080/17470218.2011.594895 Price KJ, 2012, RES AUTISM SPECT DIS, V6, P391, DOI 10.1016/j.rasd.2011.06.013 Proffitt D. R., 2008, EMBODIMENT EGO SPACE, P179 Ramenzoni VC, 2008, Q J EXP PSYCHOL, V61, P1487, DOI 10.1080/17470210802100073 Ramenzoni VC, 2008, COGNITION, V106, P1059, DOI 10.1016/j.cognition.2007.04.008 Ramenzoni VC, 2011, EXP BRAIN RES, V211, P447, DOI 10.1007/s00221-011-2653-8 Richardson MJ, 2007, J EXP PSYCHOL HUMAN, V33, P845, DOI 10.1037/0096-1523.33.4.845 Robinson S, 2009, BRAIN COGNITION, V71, P362, DOI 10.1016/j.bandc.2009.06.007 Rondan C., 2005, CURRENT PSYCHOL COGN, V23, P198 Rutter M., 2005, SCQ SOCIAL COMMUNICA Ryan JJ, 2007, J CLIN PSYCHOL, V63, P309, DOI 10.1002/jclp.20343 Sattler J. M., 2004, ASSESSMENT CHILDRE S Simion F, 2008, P NATL ACAD SCI USA, V105, P809, DOI 10.1073/pnas.0707021105 Sinzig J, 2009, J ATTEN DISORD, V13, P117, DOI 10.1177/1087054708326261 Soulieres I, 2010, COGN NEUROPSYCHOL, V27, P261, DOI 10.1080/02643294.2010.519228 Springer A, 2011, BRAIN COGNITION, V76, P26, DOI 10.1016/j.bandc.2011.03.007 Stoffregen TA, 2000, HUM MOVEMENT SCI, V19, P203, DOI 10.1016/S0167-9457(00)00009-9 Stoffregen TA, 2005, ECOL PSYCHOL, V17, P75, DOI 10.1207/s15326969eco1702_2 Theoret H, 2005, CURR BIOL, V15, pR84, DOI 10.1016/j.cub.2005.01.022 WARREN WH, 1984, J EXP PSYCHOL HUMAN, V10, P683, DOI 10.1037//0096-1523.10.5.683 WARREN WH, 1987, J EXP PSYCHOL HUMAN, V13, P371, DOI 10.1037/0096-1523.13.3.371 Wechsler D., 2003, MANUAL WECHSLER INTE, VFourth Whyatt CP, 2012, J AUTISM DEV DISORD, V42, P1799, DOI 10.1007/s10803-011-1421-8 Williams JHG, 2004, J AUTISM DEV DISORD, V34, P285, DOI 10.1023/B:JADD.0000029551.56735.3a WING L, 1981, PSYCHOL MED, V11, P115 Witt JK, 2005, J EXP PSYCHOL HUMAN, V31, P880, DOI 10.1037/0096-1523.31.5.880 Yu YW, 2011, J MOTOR BEHAV, V43, P45, DOI 10.1080/00222895.2010.533213 Zalla T, 2010, EXP BRAIN RES, V201, P809, DOI 10.1007/s00221-009-2096-7 NR 84 TC 5 Z9 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2012 VL 5 IS 5 BP 352 EP 362 DI 10.1002/aur.1248 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 023WI UT WOS:000310067300005 PM 22961977 ER PT J AU Hedley, D Young, R Brewer, N AF Hedley, Darren Young, Robyn Brewer, Neil TI Using Eye Movements as an Index of Implicit Face Recognition in Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE face recognition; autism spectrum disorder; Asperger syndrome; face perception; eye movement-based memory effect ID ASPERGER-SYNDROME; COVERT RECOGNITION; YOUNG-CHILDREN; MEMORY TEST; INDIVIDUALS; FAMILIARITY; PROSOPAGNOSIA; PERFORMANCE; ALGORITHMS; FIXATIONS AB Individuals with an autism spectrum disorder (ASD) typically show impairment on face recognition tasks. Performance has usually been assessed using overt, explicit recognition tasks. Here, a complementary method involving eye tracking was used to examine implicit face recognition in participants with ASD and in an intelligence quotient-matched non-ASD control group. Differences in eye movement indices between target and foil faces were used as an indicator of implicit face recognition. Explicit face recognition was assessed using oldnew discrimination and reaction time measures. Stimuli were faces of studied (target) or unfamiliar (foil) persons. Target images at test were either identical to the images presented at study or altered by changing the lighting, pose, or by masking with visual noise. Participants with ASD performed worse than controls on the explicit recognition task. Eye movement-based measures, however, indicated that implicit recognition may not be affected to the same degree as explicit recognition. Autism Res 2012, 5: 363379. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Hedley, Darren; Young, Robyn; Brewer, Neil] Flinders Univ S Australia, Sch Psychol, Adelaide, SA 5001, Australia. RP Young, R (reprint author), Flinders Univ S Australia, Sch Psychol, GPO Box 2100, Adelaide, SA 5001, Australia. EM robyn.young@flinders.edu.au FU ARC [LE0882562, DP1093210]; Flinders University; DOD Counterdrug Technology Development Program Office FX This research was supported by (a) ARC LE0882562 to Neil Brewer, Robyn Young et al., and ARC DP1093210 to Neil Brewer et al., (b) a Flinders University Research Grant to Robyn Young and Neil Brewer. Portions of this research used the FERET database of facial images collected under the FERET program, sponsored by the DOD Counterdrug Technology Development Program Office (Phillips et al., 1998, 2000). We are especially grateful to the individuals who participated in this study, to Jon Martin and Autism SA, to Paul Williamson, and particularly to Ben Maddock for technical support. The authors declare no financial or other potential conflicts of interest associated with this study. CR Aloisi BA, 2004, BRIT J DEV PSYCHOL, V22, P275, DOI 10.1348/026151004323044618 Althoff R, 1999, CURRENT OCULOMOTOR RESEARCH, P293 Althoff R. R., 1998, THESIS U ILLINOIS UR Althoff R. R., 1993, Society for Neuroscience Abstracts, V19, P439 Althoff RR, 1999, J EXP PSYCHOL LEARN, V25, P997, DOI 10.1037/0278-7393.25.4.997 American Psychiatric Association, 2000, DIGN STAT MAN MENT D Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Barton JJS, 2006, PERCEPTION, V35, P1089, DOI 10.1068/p5547 Bate S, 2008, CORTEX, V44, P806, DOI 10.1016/j.cortex.2007.02.004 Bate S, 2009, NEUROPSYCHOLOGY, V23, P658, DOI 10.1037/a0014518 BAUER RM, 1984, NEUROPSYCHOLOGIA, V22, P457, DOI 10.1016/0028-3932(84)90040-X Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002 Bradley C. A., 2012, EYETRACKIDS EY TRACK BURTON AM, 1991, COGNITION, V39, P129, DOI 10.1016/0010-0277(91)90041-2 Calder AJ, 2005, NAT REV NEUROSCI, V6, P641, DOI 10.1038/nrn1724 Churches O, 2010, NEUROREPORT, V21, P399, DOI 10.1097/WNR.0b013e328334311b Dawson G, 2004, DEVELOPMENTAL SCI, V7, P340, DOI 10.1111/j.1467-7687.2004.00352.x Dawson G, 2002, CHILD DEV, V73, P700, DOI 10.1111/1467-8624.00433 Di Lollo V., 2010, TUTORIALS VISUAL COG, P9 Duchaine B, 2006, NEUROPSYCHOLOGIA, V44, P576, DOI 10.1016/j.neuropsychologia.2005.07.001 FARAH MJ, 1993, PSYCHOL REV, V100, P571, DOI 10.1037/0033-295X.100.4.571 Foulsham T., 2008, J VISION, V8, P1, DOI [10.1167/8.2.6, DOI 10.1167/8.2.6] GILLBERG IC, 1989, J CHILD PSYCHOL PSYC, V30, P631, DOI 10.1111/j.1469-7610.1989.tb00275.x Hannula D. E., 2010, FRONT HUM NEUROSCI, V4, P1, DOI DOI 10.3389/FNHUM.2010.00166 Hannula DE, 2012, PSYCHOL SCI, V23, P278, DOI 10.1177/0956797611429799 Hedley D, 2011, AUTISM RES, V4, P449, DOI 10.1002/aur.214 Heisz J.J., 2008, J VISION, V8, P1, DOI DOI 10.1167/8.1.9 Herzmann G, 2008, BEHAV RES METHODS, V40, P840, DOI 10.3758/BRM.40.3.840 Herzmann G., 2007, SCI EMOTIONAL INTELL, P305 Holm L., 2007, THESIS UMEA U SWEDEN Holm L, 2008, J VISION, V8, DOI 10.1167/8.4.14 Hsiao J. H., 2007, J VIS, V7, p494a Hsiao JHW, 2008, PSYCHOL SCI, V19, P998, DOI 10.1111/j.1467-9280.2008.02191.x Kafkas A, 2011, Q J EXP PSYCHOL, V64, P1971, DOI 10.1080/17470218.2011.588335 Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Morgante JD, 2012, INFANCY, V17, P9, DOI 10.1111/j.1532-7078.2011.00089.x Moscovitch M, 2008, CAN J EXP PSYCHOL, V62, P62, DOI 10.1037/1196-1961.62.1.62 O'Hearn K, 2010, NEUROPSYCHOLOGIA, V48, P3955, DOI 10.1016/j.neuropsychologia.2010.08.024 Parkin A. J., 1990, EUROPEAN J COGNITIVE, V2, P71, DOI 10.1080/09541449008406198 Phillips PJ, 2000, IEEE T PATTERN ANAL, V22, P1090, DOI 10.1109/34.879790 Phillips PJ, 1998, IMAGE VISION COMPUT, V16, P295, DOI 10.1016/S0262-8856(97)00070-X Russell R, 2009, PSYCHON B REV, V16, P252, DOI 10.3758/PBR.16.2.252 Ryan JD, 2007, MEMORY, V15, P508, DOI 10.1080/09658210701391022 Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331 Scott FJ, 2002, AUTISM, V6, P9, DOI 10.1177/1362361302006001003 SNODGRASS JG, 1988, J EXP PSYCHOL GEN, V117, P34, DOI 10.1037//0096-3445.117.1.34 Stanislaw H, 1999, BEHAV RES METH INS C, V31, P137, DOI 10.3758/BF03207704 Sterling L, 2008, J AUTISM DEV DISORD, V38, P1666, DOI 10.1007/s10803-008-0550-1 Wechsler D, 1999, WECHSLER ABBREVIATED Weigelt S, 2012, NEUROSCI BIOBEHAV R, V36, P1060, DOI 10.1016/j.neubiorev.2011.12.008 Wilkinson DA, 2010, J AUTISM DEV DISORD, V40, P1371, DOI 10.1007/s10803-010-0995-x Williams DL, 2005, ARCH CLIN NEUROPSYCH, V20, P1, DOI 10.1016/j.acn.2002.08.001 Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56 NR 54 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2012 VL 5 IS 5 BP 363 EP 379 DI 10.1002/aur.1246 PG 17 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 023WI UT WOS:000310067300006 PM 22865711 ER PT J AU Honekopp, J AF Hoenekopp, Johannes TI Digit Ratio 2D:4D in Relation to Autism Spectrum Disorders, Empathizing, and Systemizing: A Quantitative Review SO AUTISM RESEARCH LA English DT Review DE autism; digit ratio; prenatal testosterone; empathizing; systemizing; sex differences ID MALE BRAIN THEORY; DIRECT FINGER MEASUREMENTS; FETAL TESTOSTERONE; EYES TEST; SEX-DIFFERENCES; 2D4D; METAANALYSIS; 2ND; 2D-4D; POPULATION AB Prenatal testosterone (PT) effects have been proposed to increase systemizing (the drive to understand lawful inputoutput relationships), to decrease empathizing (the drive to understand others), and to cause autism via hypermasculinization of the brain. Digit ratio 2D:4D is a putative marker of PT effects in humans. An online study (n?=?1896) into the relationship between the Reading the Mind in the Eyes Test (a widely used measure of empathizing) and self-measured 2D:4D in a nonclinical sample is reported. No evidence for a link between empathizing and 2D:4D in either females or males emerged. Further, three meta-analyses are presented that look into the relationships of 2D:4D with autism spectrum disorder (ASD), systemizing, and empathizing. 2D:4D was substantially lower (more masculine) in ASD-affected individuals than in normal controls (d?=?-0.58, P?3.0.CO;2-2 Schmidt FL, 2009, BRIT J MATH STAT PSY, V62, P97, DOI 10.1348/000711007X255327 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x STROMLAND K, 1994, DEV MED CHILD NEUROL, V36, P351 Sugie Y, 2010, BRAIN DEV-JPN, V32, P356, DOI 10.1016/j.braindev.2009.05.005 Trivers R, 2006, HORM BEHAV, V49, P150, DOI 10.1016/j.yhbeh.2005.05.023 Valla JM, 2010, AUTISM RES, V3, P174, DOI 10.1002/aur.143 van Honka J, 2011, P NATL ACAD SCI USA, V108, P3448, DOI 10.1073/pnas.1011891108 Van den Bergh B, 2006, P R SOC B, V273, P2091, DOI 10.1098/rspb.2006.3550 von Horn A., 2009, SCAND J PSYCHOL, V51, P31 Voracek M, 2011, PERS INDIV DIFFER, V51, P417, DOI 10.1016/j.paid.2010.06.009 Voracek M, 2006, PERS INDIV DIFFER, V41, P1481, DOI 10.1016/j.paid.2006.06.009 Voracek M, 2010, PERS INDIV DIFFER, V48, P72, DOI 10.1016/j.paid.2009.08.019 Wakabayashi A, 2010, PERS INDIV DIFFER, V49, P928, DOI 10.1016/j.paid.2010.07.032 Zheng ZG, 2011, P NATL ACAD SCI USA, V108, P16289, DOI 10.1073/pnas.1108312108 NR 65 TC 8 Z9 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2012 VL 5 IS 4 BP 221 EP 230 DI 10.1002/aur.1230 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 991WF UT WOS:000307733300001 PM 22674640 ER PT J AU Cascio, CJ Moana, EJ Guest, S Nebel, MB Weisner, J Baranek, GT Essick, GK AF Cascio, Carissa J. Moana-Filho, Estephan J. Guest, Steve Nebel, Mary Beth Weisner, Jonathan Baranek, Grace T. Essick, Gregory K. TI Perceptual and Neural Response to Affective Tactile Texture Stimulation in Adults with Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE touch; fMRI; sensory; adults; psychophysics; affective ID HUMAN BRAIN; UNMYELINATED AFFERENTS; DEVELOPMENTAL DELAYS; SENSORY FEATURES; SOCIAL COGNITION; FUNCTIONAL MRI; HAIRY SKIN; CHILDREN; TOUCH; TODDLERS AB Autism spectrum disorders (ASD) are associated with differences in sensory sensitivity and affective response to sensory stimuli, the neural basis of which is still largely unknown. We used psychophysics and functional magnetic resonance imaging (fMRI) to investigate responses to somatosensory stimulation with three textured surfaces that spanned a range of roughness and pleasantness in a sample of adults with ASD and a control group. While psychophysical ratings of roughness and pleasantness were largely similar across the two groups, the ASD group gave pleasant and unpleasant textures more extreme average ratings than did controls. In addition, their ratings for a neutral texture were more variable than controls, indicating they are less consistent in evaluating a stimulus that is affectively ambiguous. Changes in brain blood oxygenation level-dependent (BOLD) signal in response to stimulation with these textures differed substantially between the groups, with the ASD group exhibiting diminished responses compared to the control group, particularly for pleasant and neutral textures. For the most unpleasant texture, the ASD group exhibited greater BOLD response than controls in affective somatosensory processing areas such as the posterior cingulate cortex and the insula. The amplitude of response in the insula in response to the unpleasant texture was positively correlated with social impairment as measured by the Autism Diagnostic Interview-Revised (ADI-R). These results suggest that people with ASD tend to show diminished response to pleasant and neutral stimuli, and exaggerated limbic responses to unpleasant stimuli, which may contribute to diminished social reward associated with touch, perpetuating social withdrawal, and aberrant social development. Autism Res 2012,5:231244. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Cascio, Carissa J.] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37235 USA. [Moana-Filho, Estephan J.; Guest, Steve; Weisner, Jonathan; Essick, Gregory K.] Univ N Carolina, Sch Dent, Ctr Neurosensory Disorders, Chapel Hill, NC USA. [Baranek, Grace T.] Univ N Carolina, Dept Allied Hlth Sci, Div Occupat Sci & Occupat Therapy, Chapel Hill, NC USA. [Cascio, Carissa J.] Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN USA. [Nebel, Mary Beth] Johns Hopkins Univ, Kennedy Krieger Inst, Baltimore, MD USA. RP Cascio, CJ (reprint author), Vanderbilt Univ, Dept Psychiat, 1601 23rd Ave S,Suite 3057, Nashville, TN 37235 USA. EM carissa.cascio@vanderbilt.edu RI Nebel, Mary Beth/D-3305-2015 OI Nebel, Mary Beth/0000-0003-0185-3382 FU Autism Speaks [2082] FX This work was supported by Autism Speaks (#2082 awarded to G. K. E). The authors wish to thank Rachael Wachter, Abigail Carroll-Sharpe, Ryan Allred, Thomas Pardue, and John Bulluck for assistance with data collection and management, as well as the participants who generously shared their time and effort for this study. None of the authors have conflicts of interest to declare. CR American Psychiatric Association, 2000, DSM 4 TR DIAGN STAT, VFourth Augustine JR, 1996, BRAIN RES REV, V22, P229, DOI 10.1016/S0165-0173(96)00011-2 Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650 Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x Bastiaansen J.A., BIOL PSYCHIAT, V69, P832 Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013 Boyd BA, 2010, AUTISM RES, V3, P78, DOI 10.1002/aur.124 Brett M., 2002, 8 INT C FUNCT MAPP H Brownell CA, 2010, CHILD DEV, V81, P797, DOI 10.1111/j.1467-8624.2010.01434.x Cascio C, 2008, J AUTISM DEV DISORD, V38, P127, DOI 10.1007/s10803-007-0370-8 Coskun MA, 2009, NEUROREPORT, V20, P175, DOI 10.1097/WNR.0b013e32831f47d1 Damiano C.D., 2011, 10 ANN INT M AUT RES Dawson G, 2000, J AUTISM DEV DISORD, V30, P415, DOI 10.1023/A:1005547422749 Decety J, 2003, NEUROPSYCHOLOGIA, V41, P127, DOI 10.1016/S0028-3932(02)00143-4 Diedrichsen J, 2005, NEUROIMAGE, V27, P624, DOI 10.1016/j.neuroimage.2005.04.039 Downar J, 2002, J NEUROPHYSIOL, V87, P615 Essick GK, 2010, NEUROSCI BIOBEHAV R, V34, P192, DOI 10.1016/j.neubiorev.2009.02.003 Field T., 2001, TOUCH Foss-Feig JH, 2012, RES AUTISM SPECT DIS, V6, P337, DOI 10.1016/j.rasd.2011.06.007 Gallese V, 2003, PSYCHOPATHOLOGY, V36, P171, DOI 10.1159/000072786 Gillott Alinda, 2007, J Intellect Disabil, V11, P359, DOI 10.1177/1744629507083585 Gordon I, 2013, HUM BRAIN MAPP, V34, P914, DOI 10.1002/hbm.21480 Guclu B, 2007, SOMATOSENS MOT RES, V24, P21, DOI 10.1080/08990220601179418 Guest S, 2009, ACTA PSYCHOL, V130, P115, DOI 10.1016/j.actpsy.2008.10.007 Guest S, 2011, ATTEN PERCEPT PSYCHO, V73, P531, DOI 10.3758/s13414-010-0037-y Hagen MC, 2002, J NEUROPHYSIOL, V88, P1400, DOI 10.1152/jn.00940.2001 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 HARLOW HF, 1962, B MENNINGER CLIN, V26, P213 Hertenstein MJ, 2006, GENET SOC GEN PSYCH, V132, P5, DOI 10.3200/MONO.132.1.5-94 Hetherington MM, 2002, APPETITE, V38, P19, DOI 10.1006/appe.2001.0442 Hilton CL, 2010, J AUTISM DEV DISORD, V40, P937, DOI 10.1007/s10803-010-0944-8 Jones RSP, 2003, J INTELLECT DEV DIS, V28, P112, DOI 10.1080/1366825031000147058 Kanner L, 1943, NERV CHILD, V2, P217 Kientz MA, 1997, AM J OCCUP THER, V51, P530 Kitada R, 2010, NEUROIMAGE, V49, P1677, DOI 10.1016/j.neuroimage.2009.09.014 Kulkarni B, 2005, EUR J NEUROSCI, V21, P3133, DOI 10.1111/j.1460-9568.2005.04098.x Lancaster JL, 1997, HUM BRAIN MAPP, V5, P238, DOI 10.1002/(SICI)1097-0193(1997)5:4<238::AID-HBM6>3.0.CO;2-4 Lancaster JL, 2000, HUM BRAIN MAPP, V10, P120, DOI 10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8 Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2 Le Couteur A., 2003, AUTISM DIAGNOSTIC IN Lecanuet J.P., 2002, INTELLECTICA, V34, P29 Lieberman MD, 2009, SOC COGN AFFECT NEUR, V4, P423, DOI 10.1093/scan/nsp052 Lindgren L., 2012, NEUROIMAGE, V59, P3424 Loken LS, 2009, NAT NEUROSCI, V12, P547, DOI 10.1038/nn.2312 Loken LS, 2011, BRAIN RES, V1417, P9, DOI 10.1016/j.brainres.2011.08.011 Lord C., 1999, AUTISM DIAGNOSTIC OB Macaluso E, 2004, NEUROIMAGE, V21, P725, DOI 10.1016/j.neuroimage.2003.09.049 MAIN M, 1981, J AM ACAD CHILD PSY, V20, P292, DOI 10.1016/S0002-7138(09)60990-0 McCabe C, 2008, SOC COGN AFFECT NEUR, V3, P97, DOI 10.1093/scan/nsn005 McGlone F., 2007, CAN J EXP PSYCHOL, V61, P171 Meltzoff AN, 2007, DEVELOPMENTAL SCI, V10, P126, DOI 10.1111/j.1467-7687.2007.00574.x MESULAM MM, 1977, BRAIN RES, V136, P393, DOI 10.1016/0006-8993(77)90066-X Montagu Ashley, 1986, TOUCHING HUMAN SIGNI Morrison I, 2010, EXP BRAIN RES, V204, P305, DOI 10.1007/s00221-009-2007-y Muller RA, 2003, AM J PSYCHIAT, V160, P1847, DOI 10.1176/appi.ajp.160.10.1847 MYERS BJ, 1984, DEV REV, V4, P240, DOI 10.1016/S0273-2297(84)80007-6 Nieuwenhuys R., 2012, INSULAR CORTEX REV Olausson H, 2002, NAT NEUROSCI, V5, P900, DOI 10.1038/nn896 Olausson HW, 2008, NEUROSCI LETT, V436, P128, DOI 10.1016/j.neulet.2008.03.015 Pelphrey K, 2004, MENT RETARD DEV D R, V10, P259, DOI 10.1002/mrdd Prohovnik I, 2004, PSYCHIAT RES-NEUROIM, V132, P239, DOI 10.1016/j.pscychresns.2004.03.005 Reed CL, 2005, NEUROIMAGE, V25, P718, DOI 10.1016/j.neuroimage.2004.11.044 Robins DL, 2009, BRAIN COGNITION, V69, P269, DOI 10.1016/j.bandc.2008.08.007 Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7 Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81 Ruby P, 2004, J COGNITIVE NEUROSCI, V16, P988, DOI 10.1162/0898929041502661 Sabatinelli D, 2011, NEUROIMAGE, V54, P2524, DOI 10.1016/j.neuroimage.2010.10.011 Sathian K, 2011, NEUROIMAGE, V57, P462, DOI 10.1016/j.neuroimage.2011.05.001 Schutz-Bosbach S, 2006, CURR BIOL, V16, P1830, DOI 10.1016/j.cub.2006.07.048 Soros P, 2007, BMC NEUROSCI, V8, DOI 10.1186/1471-2202-8-48 Spitoni GF, 2010, EXP BRAIN RES, V207, P185, DOI 10.1007/s00221-010-2446-5 Talairach J., 1988, COPLANAR STEREOTACTI Toal F, 2010, PSYCHOL MED, V40, P1171, DOI 10.1017/S0033291709991541 Tomchek SD, 2007, AM J OCCUP THER, V61, P190 Tommerdahl M, 2007, BRAIN RES, V1154, P116, DOI 10.1016/j.brainres.2007.04.032 Towgood KJ, 2009, NEUROPSYCHOLOGIA, V47, P2981, DOI 10.1016/j.neuropsychologia.2009.06.028 Vallbo AB, 1999, J NEUROPHYSIOL, V81, P2753 Watson LR, 2011, J SPEECH LANG HEAR R, V54, P1562, DOI 10.1044/1092-4388(2011/10-0029) Wechsler D., 2003, WECHSLER INTELLIGENC Weiss SJ, 2000, INFANT BEHAV DEV, V23, P91, DOI 10.1016/S0163-6383(00)00030-8 Williams JHG, 2008, AUTISM RES, V1, P73, DOI 10.1002/aur.15 Wolpert DM, 1998, NAT NEUROSCI, V1, P529, DOI 10.1038/2245 NR 83 TC 16 Z9 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2012 VL 5 IS 4 BP 231 EP 244 DI 10.1002/aur.1224 PG 14 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 991WF UT WOS:000307733300002 PM 22447729 ER PT J AU Shokouhi, M Williams, JHG Waiter, GD Condon, B AF Shokouhi, Mahsa Williams, Justin H. G. Waiter, Gordon D. Condon, Barrie TI Changes in the Sulcal Size Associated With Autism Spectrum Disorder Revealed by Sulcal Morphometry SO AUTISM RESEARCH LA English DT Article DE autism; sulcal morphometry; MRI; Brainvisa ID CORTICAL FOLDING ABNORMALITIES; SOCIAL COGNITION; CEREBRAL-CORTEX; BRAIN; INDIVIDUALS; VARIABILITY; DEFICITS; SYSTEM; SCALE; MRI AB Autism spectrum disorder (ASD) is a complex, neurodevelopmental disorder with various structural abnormalities for different patient groups. Because of the heterogeneity of the disorder, several biomarkers have been suggested so far. Here, we explore the potential of sulcal surface and length as biomarkers. Three-dimensional T1-weighted images of 15 adolescents of normal intelligence with ASD and 15 age-, sex-, and intelligence quotient-matched control adolescents were analysed using Brainvisa 4.0 (http://www.brainvisa.info), which automatically extracts the cortical folds and labels them as 59 sulcal pieces. For each sulcus, the surface, length, and mean geodesic depth were computed using morphometry analysis within this software package. General linear model was conducted to compare the estimated values for the two groups, ASD and control. In the ASD group, the left insula and the right intraparietal sulcus (IPS) had significantly higher values for surface and length, respectively. Nonetheless for all sulcal pieces, the mean geodesic depth was not significantly different between the two groups. Our results suggest that sulcal surface and length can have correlation with morphological changes of cortex in ASD. Greater surface area and length in insula and IPS, respectively, may reflect greater folding. This could result in greater separation of functions with an impact upon the integrative functions of these regions. Autism Res 2012, 5: 245252. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Shokouhi, Mahsa] Univ Glasgow, Dept Clin Phys & Psychol Med, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland. [Williams, Justin H. G.] Univ Aberdeen, Sch Med, Aberdeen, Scotland. [Waiter, Gordon D.] Univ Aberdeen, Aberdeen Biomed Imaging Ctr, Div Appl Med, Aberdeen, Scotland. [Condon, Barrie] So Gen Hosp, Dept Clin Phys & Bioengn, Inst Neurol Sci, Glasgow G51 4TF, Lanark, Scotland. RP Shokouhi, M (reprint author), So Gen Hosp, MRI Dept, Inst Neurol Sci, Govan Rd, Glasgow G51 4TF, Lanark, Scotland. EM m.shokouhi.1@research.gla.ac.uk FU SINAPSE FX This study was supported by SINAPSE (http://www.sinapse.ac.uk). CR Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004 Driemeyer J, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002669 Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010 Fischl B, 1999, NEUROIMAGE, V9, P195, DOI 10.1006/nimg.1998.0396 Gallese V, 2004, TRENDS COGN SCI, V8, P396, DOI 10.1016/j.tics.2004.07.002 Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069 Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kates WR, 2009, AUTISM RES, V2, P267, DOI 10.1002/aur.98 Le Goualher G, 1999, IEEE T MED IMAGING, V18, P206, DOI 10.1109/42.764891 Levitt JG, 2003, CEREB CORTEX, V13, P728, DOI 10.1093/cercor/13.7.728 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Mangin JF, 1996, PROCEEDINGS OF THE IEEE WORKSHOP ON MATHEMATICAL METHODS IN BIOMEDICAL IMAGE ANALYSIS, P319, DOI 10.1109/MMBIA.1996.534084 Mangin J.-F., 2000, Proceedings IEEE Workshop on Mathematical Methods in Biomedical Image Analysis. MMBIA-2000 (Cat. No.PR00737), DOI 10.1109/MMBIA.2000.852374 Mangin J.-F., 1995, Journal of Mathematical Imaging and Vision, V5, DOI 10.1007/BF01250286 Mangin JF, 1998, LECT NOTES COMPUT SC, V1496, P1230 Mangin JF, 2004, IEEE T MED IMAGING, V23, P968, DOI 10.1109/TMI.2004.831204 McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150 McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332 Muller KR, 2001, IEEE T NEURAL NETWOR, V12, P181, DOI 10.1109/72.914517 Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007 OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4 Ono M., 1990, ATLAS CEREBRAL SULCI Perrot M, 2009, LECT NOTES COMPUT SC, V5636, P176, DOI 10.1007/978-3-642-02498-6_15 Perrot M., 2008, IEEE INT S BIOM IM N, p[1, 420] Plaze M, 2011, SCHIZOPHRENIA BULL, V37, P212, DOI 10.1093/schbul/sbp081 Radua J, 2011, PSYCHOL MED, V41, P1539, DOI 10.1017/S0033291710002187 Regis J, 2005, NEUROL MED-CHIR, V45, P1, DOI 10.2176/nmc.45.1 Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56 Uddin LQ, 2009, NEUROSCI BIOBEHAV R, V33, P1198, DOI 10.1016/j.neubiorev.2009.06.002 Van Essen DC, 2005, NEUROIMAGE, V28, P635, DOI 10.1016/j.neuroimage.2005.06.058 Van Essen DC, 2006, J NEUROSCI, V26, P5470, DOI 10.1523/JNEUROSCI.4154-05.2006 Waiter GD, 2004, NEUROIMAGE, V22, P619, DOI 10.1016/j.neuroimage.2004.02.029 Waiter GD, 2005, NEUROIMAGE, V24, P455, DOI 10.1016/j.neuroimage.2004.08.049 WECHSLER D, 1982, REV PSYCHOL APPL, V32, P63 WECHSLER D, 1981, CONTEMP EDUC PSYCHOL, V6, P82, DOI 10.1016/0361-476X(81)90035-7 Williams JHG, 2008, AUTISM RES, V1, P73, DOI 10.1002/aur.15 Williams JHG, 2006, NEUROPSYCHOLOGIA, V44, P610, DOI 10.1016/j.neuropsychologia.2005.06.010 NR 39 TC 8 Z9 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2012 VL 5 IS 4 BP 245 EP 252 DI 10.1002/aur.1232 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 991WF UT WOS:000307733300003 PM 22674695 ER PT J AU Key, APF Stone, WL AF Key, Alexandra P. F. Stone, Wendy L. TI Same but Different: 9-Month-Old Infants at Average and High Risk for Autism Look at the Same Facial Features but Process Them Using Different Brain Mechanisms SO AUTISM RESEARCH LA English DT Article DE face processing; ERP; eye tracking; infants; ASD; Vineland ID EVENT-RELATED POTENTIALS; SPECTRUM DISORDER; GAZE BEHAVIOR; ELECTROPHYSIOLOGICAL EVIDENCE; RECOGNITION MEMORY; YOUNGER SIBLINGS; FACE RECOGNITION; HOME VIDEOTAPES; 1ST YEAR; CHILDREN AB The study examined whether 9-month-old infants at average vs. high risk for autism spectrum disorder (ASD) process facial features (eyes, mouth) differently and whether such differences are related to infants' social and communicative skills. Eye tracking and visual event-related potentials (ERPs) were recorded in 35 infants (20 average-risk typical infants, 15 high-risk siblings of children with ASD) while they viewed photographs of a smiling unfamiliar female face. On 30% of the trials, the eyes or the mouth of that face was replaced with corresponding features from a different female. There were no group differences in the number, duration, or distribution of fixations, and all infants looked at the eyes and mouth regions equally. However, increased attention to the mouth was associated with weaker receptive communication skills and increased attention to the eyes correlated with better interpersonal skills. ERP results revealed that all infants detected eye and mouth changes but did so using different brain mechanisms. Changes in facial features were associated with changes in activity of the face perception mechanisms (N290) for the average-risk group but not for the high-risk infants. For all infants, correlations between ERP and eye-tracking measures indicated that larger and faster ERPs to feature changes were associated with fewer fixations on the irrelevant regions of stimuli. The size and latency of the ERP responses also correlated with parental reports of receptive and expressive communication skills, suggesting that differences in brain processing of human faces are associated with individual differences in social-communicative behaviors. Autism Res 2012, 5: 253266. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Key, Alexandra P. F.] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37203 USA. [Key, Alexandra P. F.] Vanderbilt Univ, Dept Hearing & Speech Sci, Nashville, TN 37203 USA. [Stone, Wendy L.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA. [Stone, Wendy L.] Univ Washington, UW Autism Ctr, Seattle, WA 98195 USA. RP Key, APF (reprint author), Vanderbilt Univ, Vanderbilt Kennedy Ctr, 230 Appleton Pl,Peabody Box 74, Nashville, TN 37203 USA. EM sasha.key@vanderbilt.edu FU Marino Autism Research Institute (MARI); NICHD [P30 HD15052] FX The authors declare no conflict of interest. This work was supported in part by a Marino Autism Research Institute (MARI) Discovery Award to Dr. Alexandra Key and by NICHD Grant P30 HD15052 to Vanderbilt Kennedy Center. We would like to thank Ms. Susan M. Williams, Ms. Stephanie Bradshaw, and Ms. Katie Knoedelseder for their assistance in recruiting and testing the participants. CR Bahrick LE, 1998, CHILD DEV, V69, P1263, DOI 10.2307/1132264 Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650 Bar-Haim Y, 2006, J AUTISM DEV DISORD, V36, P131, DOI 10.1007/s10803-005-0046-1 BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289 Bentin S, 2006, J COGNITIVE NEUROSCI, V18, P1406, DOI 10.1162/jocn.2006.18.8.1406 Burden MJ, 2007, PEDIATRICS, V120, pE336, DOI 10.1542/peds.2006-2525 Cheour M, 1998, NAT NEUROSCI, V1, P351, DOI 10.1038/1561 COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155 COURCHESNE E, 1981, CHILD DEV, V52, P804, DOI 10.1111/j.1467-8624.1981.tb03117.x Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327 deHaan M, 1997, CHILD DEV, V68, P187, DOI 10.2307/1131845 de Haan M, 2003, INT J PSYCHOPHYSIOL, V51, P45, DOI 10.1016/S0167-8760(03)00152-1 de Haan M, 2004, J CHILD PSYCHOL PSYC, V45, P1209, DOI 10.1111/j.1469-7610.2004.00320.x Elder LM, 2008, J AUTISM DEV DISORD, V38, P1104, DOI 10.1007/s10803-007-0495-9 Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005 Elsabbagh M, 2009, BIOL PSYCHIAT, V65, P31, DOI 10.1016/j.biopsych.2008.09.034 Halit H, 2003, NEUROIMAGE, V19, P1180, DOI 10.1016/S1053-8119(03)00076-4 HOCHBERG Y, 1988, BIOMETRIKA, V75, P800, DOI 10.1093/biomet/75.4.800 Hunnius S, 2004, INFANT BEHAV DEV, V27, P397, DOI 10.1016/j.infbeh.2004.02.003 Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5 Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142 Key APF, 2009, INFANT CHILD DEV, V18, P149, DOI 10.1002/icd.600 Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 Kuhl PK, 2006, DEVELOPMENTAL SCI, V9, pF13, DOI 10.1111/j.1467-7687.2006.00468.x LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x Lansing CR, 1999, J SPEECH LANG HEAR R, V42, P526 Luyster RJ, 2011, BRAIN TOPOGR, V24, P220, DOI 10.1007/s10548-011-0176-z Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02 McCleery JP, 2009, BIOL PSYCHIAT, V66, P950, DOI 10.1016/j.biopsych.2009.07.031 McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x Merin N, 2007, J AUTISM DEV DISORD, V37, P108, DOI 10.1007/s10803-006-0342-4 Nadig AS, 2007, ARCH PEDIAT ADOL MED, V161, P378, DOI 10.1001/archpedi.161.4.378 Nelson CA, 2001, INFANT CHILD DEV, V10, P3, DOI 10.1002/icd.239 OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225 Osterling JA, 2002, DEV PSYCHOPATHOL, V14, P239 Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009 Pascalis O, 2002, SCIENCE, V296, P1321, DOI 10.1126/science.1070223 Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369 Reynolds GD, 2005, DEV PSYCHOL, V41, P598, DOI 10.1037/0012-1649.41.4.598 Rogers SJ, 2009, AUTISM RES, V2, P125, DOI 10.1002/aur.81 Rozga A., 2010, J AUTISM DEV DISORD, V41, P287, DOI 10.1007/s10803-010-1051-6 Rubin D., 1987, MULTIPLE IMPUTATION Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1371, DOI 10.1007/s10803-007-0525-7 Schwarzer G, 2005, MEM COGNITION, V33, P344, DOI 10.3758/BF03195322 Scott LS, 2006, PERCEPTION, V35, P1107, DOI 10.1068/p5493 Sparrow SS, 2005, VINELAND ADAPTIVE BE Stone WL, 2007, ARCH PEDIAT ADOL MED, V161, P384, DOI 10.1001/archpedi.161.4.384 Taylor MJ, 2001, NEUROREPORT, V12, P1671, DOI 10.1097/00001756-200106130-00031 Thomas DG, 2004, DEV NEUROPSYCHOL, V26, P753, DOI 10.1207/s15326942dn2603_6 van der Geest JN, 2002, J CHILD PSYCHOL PSYC, V43, P669, DOI 10.1111/1469-7610.00055 Volkmar FR, 2004, J CHILD PSYCHOL PSYC, V45, P135, DOI 10.1046/j.0021-9630.2003.00317.x VOLKMAR FR, 1989, J CHILD PSYCHOL PSYC, V30, P591, DOI 10.1111/j.1469-7610.1989.tb00270.x Werner E, 2000, J AUTISM DEV DISORD, V30, P157, DOI 10.1023/A:1005463707029 Westfall P. H., 1999, MULTIPLE COMP MULTIP Westfall P. H., 1993, RESAMPLING BASED MUL Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y Young GS, 2009, DEVELOPMENTAL SCI, V12, P798, DOI 10.1111/j.1467-7687.2009.00833.x Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001 NR 60 TC 11 Z9 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2012 VL 5 IS 4 BP 253 EP 266 DI 10.1002/aur.1231 PG 14 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 991WF UT WOS:000307733300004 PM 22674669 ER PT J AU Shumway, S Farmer, C Thurm, A Joseph, L Black, D Golden, C AF Shumway, Stacy Farmer, Cristan Thurm, Audrey Joseph, Lisa Black, David Golden, Christine TI The ADOS Calibrated Severity Score: Relationship to Phenotypic Variables and Stability over Time SO AUTISM RESEARCH LA English DT Article DE autism diagnostic observation schedule (ADOS); autism spectrum disorders; severity; diagnosis ID AUTISM SPECTRUM DISORDERS; DIAGNOSTIC OBSERVATION SCHEDULE; VALIDITY; CHILDREN; AGE AB Measurement of the severity of autism at a single time point, and over time, is a widespread challenge for researchers. Recently, Gotham, Pickles, and Lord published a severity metric (calibrated severity scores; CSS) that takes into account age and language level and is based on raw total scores of the Autism Diagnostic Observation Schedule (ADOS), a standardized measure commonly used in autism diagnosis. The present study examined psychometric characteristics of the CSS compared to raw scores in an independent sample of 368 children aged 2 to 12 years with autism, pervasive developmental disorder-not otherwise specified (PDD-NOS), non-spectrum delay, or typical development. Reflecting the intended calibration, the CSS were more uniformly distributed within clinical diagnostic category and across ADOS modules than were raw scores. Cross-sectional analyses examining raw and severity scores and their relationships to participant characteristics revealed that verbal developmental level was a significant predictor of raw score but accounted for significantly less variance in the CSS. Longitudinal analyses indicated overall stability of the CSS over 12 to 24 months in children with autism. Findings from this study support the use of the CSS as a more valid indicator of autism severity than the ADOS raw total score, and extend the literature by examining the stability over 12 to 24 months of the CSS in children with ASD. Autism Res 2012, 5: 267276. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Shumway, Stacy; Farmer, Cristan; Thurm, Audrey; Joseph, Lisa; Black, David; Golden, Christine] NIMH, Pediat & Dev Neurosci Branch, Bethesda, MD 20892 USA. RP Farmer, C (reprint author), NIMH, Pediat & Dev Neurosci Branch, 10 Ctr Dr,MSC 1C250, Bethesda, MD 20892 USA. EM farmerca@mail.nih.gov FU National Institute of Mental Health (NIMH) FX This research was supported by the Intramural Program of the National Institute of Mental Health (NIMH). The views expressed in this paper do not necessarily represent the views of the NIMH, NIH, HHS, or the United Stated Government. The authors extend their gratitude for the children and their families who volunteered their time and efforts during the research. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Bishop SL, 2011, AJIDD-AM J INTELLECT, V116, P331, DOI 10.1352/1944-7558-116.5.331 Brownell R, 2000, EXPRESSIVE ONE WORD, V3rd Charman T, 2005, J CHILD PSYCHOL PSYC, V46, P500, DOI 10.1111/j.1469-7610.2004.00377.x Cohen J., 2003, APPL MULTIPLE REGRES Dawson G, 2010, PEDIATRICS, V125, pE17, DOI 10.1542/peds.2009-0958 de Bildt A, 2011, J AUTISM DEV DISORD, V41, P311, DOI 10.1007/s10803-010-1057-0 Dunn L. M., 1997, PEABODY PICTURE VOCA, V3rd Elliott C., 2007, DIFFERENTIAL ABILITY Fenson L, 1993, MACARTHUR COMMUNICAT Gilliam J. E., 1995, GILLIAM AUTISM RATIN Gotham K, 2009, J AUTISM DEV DISORD, V39, P693, DOI 10.1007/s10803-008-0674-3 Gotham K., 2008, J AM ACAD CHILD ADOL, V47, P641 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Guy W, 1976, CLIN GLOBAL IMPRESSI Hurt B., 2010, PEDIAT PSYCHOPHARMAC, P389 KRUG DA, 1980, J CHILD PSYCHOL PSYC, V21, P221, DOI 10.1111/j.1469-7610.1980.tb01797.x Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 MENG XL, 1992, PSYCHOL BULL, V111, P172, DOI 10.1037/0033-2909.111.1.172 Mullen E, 1995, MULLEN SCALES EARLY Oosterling I, 2010, J AUTISM DEV DISORD, V40, P689, DOI 10.1007/s10803-009-0915-0 Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e Rutter M., 2003, AUTISM DIAGNOSTIC IN Schaffer D., 1983, ARCH GEN PSYCHIAT, V40, P1228 Schopler E., 1986, CHILD AUTISM RATING Sparrow SS, 2005, VINELAND ADAPTIVE BE Stone WL, 1999, J CHILD PSYCHOL PSYC, V40, P219, DOI 10.1017/S0021963098003370 NR 28 TC 10 Z9 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2012 VL 5 IS 4 BP 267 EP 276 DI 10.1002/aur.1238 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 991WF UT WOS:000307733300005 PM 22628087 ER PT J AU Van der Aa, N Vandeweyer, G Reyniers, E Kenis, S Dom, L Mortier, G Rooms, L Kooy, RF AF Van der Aa, Nathalie Vandeweyer, Geert Reyniers, Edwin Kenis, Sandra Dom, Lina Mortier, Geert Rooms, Liesbeth Kooy, R. Frank TI Haploinsufficiency of CMIP in a Girl With Autism Spectrum Disorder and Developmental Delay due to a De Novo Deletion on Chromosome 16q23.2 SO AUTISM RESEARCH LA English DT Article DE language delay; autism; ASD; CMIP; intellectual disability ID GIANT AXONAL NEUROPATHY; C-MIP INTERACTS; LANGUAGE IMPAIRMENT; MENTAL-RETARDATION; SPEECH; GENE; MUTATIONS; LINKAGE; FOXP1 AB In a developmentally delayed girl with an autism spectrum disorder, Single nucleotide polymorphism (SNP) array analysis showed a de novo 280?kb deletion on chromosome 16q23.2 involving two genes, GAN and CMIP. Inactivating mutations in GAN cause the autosomal recessive disorder giant axonal neuropathy, not present in our patient. CMIP was recently implicated in the etiology of specific language impairment by genome-wide association analysis. It modulates phonological short-term memory and hence plays an important role in language acquisition. Overlaps of specific language impairment and autism have been debated in the literature regarding the phenotypical language profile as well as etiology. Our patient illustrates that haploinsufficiency of CMIP may contribute to autism spectrum disorders. Our finding further supports the existence of a genetic overlap in the etiology of specific language impairment and autism. Autism Res 2012, 5: 277281. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Van der Aa, Nathalie; Vandeweyer, Geert; Reyniers, Edwin; Mortier, Geert; Rooms, Liesbeth; Kooy, R. Frank] Univ Antwerp, Dept Med Genet, B-2020 Antwerp, Belgium. [Van der Aa, Nathalie; Vandeweyer, Geert; Reyniers, Edwin; Kenis, Sandra; Mortier, Geert; Rooms, Liesbeth; Kooy, R. Frank] Univ Antwerp Hosp, Antwerp, Belgium. [Kenis, Sandra] Univ Antwerp, Dept Neurol Childneurol, B-2020 Antwerp, Belgium. [Dom, Lina] Paola Kinderziekenhuis, Dept Pediat Neurol, Berchem, Belgium. RP Van der Aa, N (reprint author), Univ Edegem, Prins Boudewijnlaan 43, B-2650 Edegem, Belgium. EM nathalie.van.der.aa@uza.be RI Mortier, Geert/D-2542-2012 FU Belgian National Fund for Scientific Research-Flanders (FWO); Marguerite-Marie Delacroix Foundation FX We thank the patient and her family for their cooperation. Our work was generously supported by grants from the Belgian National Fund for Scientific Research-Flanders (FWO) and the Marguerite-Marie Delacroix Foundation. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005 Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307 APA, 2000, AM PSYCH ASS DIAGN S BISHOP DVM, 1994, PHILOS T ROY SOC B, V346, P105, DOI 10.1098/rstb.1994.0134 Buysse K, 2010, AM J MED GENET A, V152A, P2802, DOI 10.1002/ajmg.a.33508 Newbury DF, 2004, AM J HUM GENET, V74, P1225 Fisher SE, 2006, NAT REV GENET, V7, P9, DOI 10.1038/nrg1747 Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225 Gusev A, 2009, GENOME RES, V19, P318, DOI 10.1101/gr.081398.108 Hamdan FF, 2010, AM J HUM GENET, V87, P671, DOI 10.1016/j.ajhg.2010.09.017 Horn D, 2010, HUM MUTAT, V31, pE1851, DOI 10.1002/humu.21362 Houlden H, 2007, J NEUROL NEUROSUR PS, V78, P1267, DOI 10.1136/jnnp.2007.118968 Kamal M, 2009, MOL IMMUNOL, V46, P991, DOI 10.1016/j.molimm.2008.09.034 Kamal M, 2010, FEBS LETT, V584, P500, DOI 10.1016/j.febslet.2009.12.015 Kooy RF, 2010, MONOGR HUM GENET, V18, P126 Lai CSL, 2001, NATURE, V413, P519, DOI 10.1038/35097076 Leyfer OT, 2008, AUTISM RES, V1, P284, DOI 10.1002/aur.43 Lindgren KA, 2009, AUTISM RES, V2, P22, DOI 10.1002/aur.63 Matsuzaki H, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-11-r125 Newbury DF, 2010, NEURON, V68, P309, DOI 10.1016/j.neuron.2010.10.001 Newbury DF, 2010, GENOME MED, V2, DOI 10.1186/gm127 Newbury DF, 2011, BEHAV GENET, V41, P90, DOI 10.1007/s10519-010-9424-3 Newbury DF, 2009, AM J HUM GENET, V85, P264, DOI 10.1016/j.ajhg.2009.07.004 Pennington BF, 2009, ANNU REV PSYCHOL, V60, P283, DOI 10.1146/annurev.psych.60.110707.163548 Pickles A, 2009, J CHILD PSYCHOL PSYC, V50, P843, DOI 10.1111/j.1469-7610.2008.02032.x Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 Ramocki MB, 2008, NATURE, V455, P912, DOI 10.1038/nature07457 Robertson SP, 2005, CURR OPIN GENET DEV, V15, P301, DOI 10.1016/j.gde.2005.04.001 Rooms L, 2004, HUM MUTAT, V23, P17, DOI 10.1002/humu.10300 Scerri TS, 2011, BIOL PSYCHIAT, V70, P237, DOI 10.1016/j.biopsych.2011.02.005 Stephan DA, 2008, AM J HUM GENET, V82, P7, DOI 10.1016/j.ajhg.2007.12.003 Tager-Flusberg H, 2004, J AUTISM DEV DISORD, V34, P75, DOI 10.1023/B:JADD.0000018077.64617.5a Vandeweyer G, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-4 Vernes SC, 2008, NEW ENGL J MED, V359, P2337, DOI 10.1056/NEJMoa0802828 Vernes SC, 2007, AM J HUM GENET, V81, P1232, DOI 10.1086/522238 Williams D, 2008, PSYCHOL BULL, V134, P944, DOI [10.1037/a0013743, 10.1037/0013743] NR 37 TC 3 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2012 VL 5 IS 4 BP 277 EP 281 DI 10.1002/aur.1240 PG 5 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 991WF UT WOS:000307733300006 PM 22689534 ER PT J AU Song, YN Hakoda, Y AF Song, Yongning Hakoda, Yuji TI Selective Attention to Facial Emotion and Identity in Children With Autism: Evidence for Global Identity and Local Emotion SO AUTISM RESEARCH LA English DT Article DE facial expression; facial identity; Garner paradigm; autism spectrum disorder (ASD) ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; ASPERGER-SYNDROME; RECOGNITION; INFORMATION; PRECEDENCE; DEFICIT AB The present study sought to test the global-identity and local-emotion processing hypothesis in face perception by examining emotional interference in face perception in children with high-functioning autism/Asperger's syndrome. Participants judged either the expression or the identity of faces while identity/expression was either held constant or varied (Garner paradigm). The results revealed that emotional expressions interfered with identity processing in face perception for autism spectrum disorder individuals. Taken together with previous findings, our results suggest that emotion judgment mainly depends on local processing, while identity judgment mainly depends on global processing. Autism Res 2012, 5: 282285. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Song, Yongning; Hakoda, Yuji] Kyushu Univ, Fac Human Environm Studies, Fukuoka 8128581, Japan. [Song, Yongning] E China Normal Univ, Sch Psychol & Cognit Sci, Shanghai 200062, Peoples R China. RP Song, YN (reprint author), Kyushu Univ, Fac Human Environm Studies, 6-19-1 Hakozaki, Fukuoka 8128581, Japan. EM yongning_song@kyudai.jp FU Japan Society for the Promotion of Science; National Natural Foundation of China FX This work was supported by a Grant-in-Aid for JSPS Fellows from the Japan Society for the Promotion of Science, and also by National Natural Foundation of China. We declare that there is no conflict of interest in this paper. CR Baudouin JY, 2008, VIS COGN, V16, P933, DOI 10.1080/13506280701728990 Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002 Boraston Z, 2007, NEUROPSYCHOLOGIA, V45, P1501, DOI 10.1016/j.neuropsychologia.2006.11.010 Corden B, 2008, NEUROPSYCHOLOGIA, V46, P137, DOI 10.1016/j.neuropsychologia.2007.08.005 Ehlers S, 1999, J AUTISM DEV DISORD, V29, P129, DOI 10.1023/A:1023040610384 Ellison JW, 1997, J EXP PSYCHOL HUMAN, V23, P213, DOI 10.1037/0096-1523.23.1.213 Freire A, 2000, PERCEPTION, V29, P159, DOI 10.1068/p3012 GARNER WR, 1976, COGNITIVE PSYCHOL, V8, P98, DOI 10.1016/0010-0285(76)90006-2 Gillberg C, 2001, AUTISM, V5, P57, DOI 10.1177/1362361301005001006 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Komatsu S., 2009, JAPANESE J COGNITIVE, V6, P143 Leder H, 2006, BRIT J PSYCHOL, V97, P19, DOI 10.1348/00712605X54794 Mondloch CJ, 2002, PERCEPTION, V31, P553, DOI 10.1068/p3339 NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3 Ogawa T., 1998, TRH244 ATR Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489 Rakover SS, 1997, PERCEPT PSYCHOPHYS, V59, P752, DOI 10.3758/BF03206021 Raven J. C., 1992, STANDARD PROGR MATRI Schweinberger SR, 1998, J EXP PSYCHOL HUMAN, V24, P1748, DOI 10.1037/0096-1523.24.6.1748 Wallace S, 2008, COGNITION EMOTION, V22, P1353, DOI 10.1080/02699930701782153 Williams J., 2005, AUTISM, V11, P173 NR 21 TC 1 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2012 VL 5 IS 4 BP 282 EP 285 DI 10.1002/aur.1242 PG 4 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 991WF UT WOS:000307733300007 PM 22753237 ER PT J AU Elsabbagh, M AF Elsabbagh, Mayada TI Perspectives from the Common Ground SO AUTISM RESEARCH LA English DT Editorial Material C1 McGill Univ, Dept Psychiat, Montreal, PQ, Canada. RP Elsabbagh, M (reprint author), McGill Univ, Dept Psychiat, Montreal, PQ, Canada. NR 0 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2012 VL 5 IS 3 SI SI BP 153 EP 155 DI 10.1002/aur.1237 PG 3 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 956EN UT WOS:000305072800001 PM 22628367 ER PT J AU Khan, NZ Gallo, LA Arghir, A Budisteanu, B Budisteanu, M Dobrescu, I Donald, K El-Tabari, S Hoogenhout, M Kalambayi, F Kawa, R Espinoza, IL Lowenthal, R Malcolm-Smith, S Montiel-Nava, C Odeh, J de Paula, CS Rad, F Tarpan, AK Thomas, KGF Wang, CY Patel, V Baron-Cohen, S Elsabbagh, M AF Khan, Naila Z. Albores Gallo, Lilia Arghir, Aurora Budisteanu, Bogdan Budisteanu, Magdalena Dobrescu, Iuliana Donald, Kirsty El-Tabari, Samia Hoogenhout, Michelle Kalambayi, Fidelie Kawa, Rafal Lemus Espinoza, Isaac Lowenthal, Rosane Malcolm-Smith, Susan Montiel-Nava, Cecila Odeh, Jumana de Paula, Cristiane S. Rad, Florina Tarpan, Adelaide Katerine Thomas, Kevin G. F. Wang, Chongying Patel, Vikram Baron-Cohen, Simon Elsabbagh, Mayada TI Autism and the Grand Challenges in Global Mental Health SO AUTISM RESEARCH LA English DT Editorial Material ID DISORDERS; CHILDREN C1 [Khan, Naila Z.] Bangladesh Inst Child Hlth, Dept Pediat Neurosci, Dhaka, Bangladesh. [Albores Gallo, Lilia; Lemus Espinoza, Isaac] Hosp Psiquiatr Infantil Dr Juan N Navarro, Mexico City, DF, Mexico. [Arghir, Aurora] Victor Babes Natl Inst Pathol, Bucharest, Romania. [Budisteanu, Magdalena] Al Obregia Hosp Psychiat, Psychiat Res Lab, Bucharest, Romania. [Dobrescu, Iuliana; Rad, Florina] Al Obregia Psychiat Hosp, UMF Carol Davila, Child & Adolescent Psychiat Dept, Bucharest, Romania. [Donald, Kirsty] Red Cross Childrens Hosp, Sch Child & Adolescent Hlth, Div Dev Paediat, Cape Town, South Africa. [El-Tabari, Samia] John Aves Educ Project, Norwich, Norfolk, England. [Hoogenhout, Michelle; Thomas, Kevin G. F.] Univ Cape Town, Dept Psychol, ZA-7925 Cape Town, South Africa. [Kalambayi, Fidelie; Tarpan, Adelaide Katerine] Romanian Angel Appeal Fdn, Bucharest, Romania. [Kawa, Rafal] Polish Acad Sci, Inst Psychol, Warsaw, Poland. [Lowenthal, Rosane; de Paula, Cristiane S.] Univ Prebiteriana Mackenzie, Dev Disorder Post Graduat Program, Sao Paulo, Brazil. [Montiel-Nava, Cecila] Univ Zulia, Maracaibo 4011, Venezuela. [Odeh, Jumana] Palestinian Happy Child Ctr, Ramallah, Israel. [Wang, Chongying] Nankai Univ, Sch Med, Ctr Behav Sci, Tianjin 300071, Peoples R China. [Patel, Vikram] London Sch Hyg & Trop Med, London WC1, England. [Baron-Cohen, Simon] Univ Cambridge, Cambridge, England. [Elsabbagh, Mayada] McGill Univ, Dept Psychiat, Montreal, PQ, Canada. RP Khan, NZ (reprint author), Bangladesh Inst Child Hlth, Dept Pediat Neurosci, Dhaka, Bangladesh. RI Psiquiatria, Inct/I-1060-2013 CR Collins PY, 2011, NATURE, V475, P27, DOI 10.1038/475027a DURKIN MS, 1994, EPIDEMIOLOGY, V5, P283, DOI 10.1097/00001648-199405000-00005 Elsabbagh M, 2012, AUTISM RES, V5, P160, DOI 10.1002/aur.239 Grinker RR, 2012, AUTISM RES, V5, P201, DOI 10.1002/aur.1229 Hastings RP, 2012, J APPL RES INTELLECT, V25, P119, DOI 10.1111/j.1468-3148.2011.00680.x Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657 Myers SM, 2007, PEDIATRICS, V120, P1162, DOI 10.1542/peds.2007-2362 Patel V, 2009, INT HEALTH, V1, P37, DOI 10.1016/j.inhe.2009.02.002 Wallace S, 2012, AUTISM RES, V5, P211, DOI 10.1002/aur.1236 Warren Z, 2011, PEDIATRICS, V127, pE1303, DOI 10.1542/peds.2011-0426 Wu LA, 2011, CHILD CARE HLTH DEV, V38, P332 Xu LM, 2012, NUCLEIC ACIDS RES, V40, pD1016, DOI 10.1093/nar/gkr1145 NR 12 TC 8 Z9 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2012 VL 5 IS 3 SI SI BP 156 EP 159 DI 10.1002/aur.1239 PG 4 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 956EN UT WOS:000305072800002 PM 22605618 ER PT J AU Elsabbagh, M Divan, G Koh, YJ Kim, YS Kauchali, S Marcin, C Montiel-Nava, C Patel, V Paula, CS Wang, CY Yasamy, MT Fombonne, E AF Elsabbagh, Mayada Divan, Gauri Koh, Yun-Joo Kim, Young Shin Kauchali, Shuaib Marcin, Carlos Montiel-Nava, Cecilia Patel, Vikram Paula, Cristiane S. Wang, Chongying Yasamy, Mohammad Taghi Fombonne, Eric TI Global Prevalence of Autism and Other Pervasive Developmental Disorders SO AUTISM RESEARCH LA English DT Review DE epidemiology; prevalence; global health; low- and middle-income countries ID CHILDHOOD AUTISM; SPECTRUM DISORDERS; PRESCHOOL-CHILDREN; CHANGING PREVALENCE; YOUNG-CHILDREN; COMMUNITY; MONTREAL; PARENTS; AFRICA; SWEDEN AB We provide a systematic review of epidemiological surveys of autistic disorder and pervasive developmental disorders (PDDs) worldwide. A secondary aim was to consider the possible impact of geographic, cultural/ethnic, and socioeconomic factors on prevalence estimates and on clinical presentation of PDD. Based on the evidence reviewed, the median of prevalence estimates of autism spectrum disorders was 62/10?000. While existing estimates are variable, the evidence reviewed does not support differences in PDD prevalence by geographic region nor of a strong impact of ethnic/cultural or socioeconomic factors. However, power to detect such effects is seriously limited in existing data sets, particularly in low-income countries. While it is clear that prevalence estimates have increased over time and these vary in different neighboring and distant regions, these findings most likely represent broadening of the diagnostic concets, diagnostic switching from other developmental disabilities to PDD, service availability, and awareness of autistic spectrum disorders in both the lay and professional public. The lack of evidence from the majority of the world's population suggests a critical need for further research and capacity building in low- and middle-income countries. Autism Res 2012, 5: 160179. (c) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Elsabbagh, Mayada; Fombonne, Eric] Montreal Childrens Hosp, Dept Psychiat, Montreal, PQ H3Z 1P2, Canada. [Elsabbagh, Mayada] Univ London, London, England. [Koh, Yun-Joo] Korea Inst Childrens Social Dev, Seoul, South Korea. [Kim, Young Shin] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA. [Kauchali, Shuaib] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Durban, South Africa. [Kauchali, Shuaib] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA. [Marcin, Carlos] Mexican Autism Clin, Mexico City, DF, Mexico. [Montiel-Nava, Cecilia] Univ Zulia, Dept Psychol, Maracaibo 4011, Venezuela. [Patel, Vikram] London Sch Hyg & Trop Med, Ctr Global Mental Hlth, London WC1, England. [Paula, Cristiane S.] Univ Prebiteriana Mackenzie, Dev Disorders Program, Sao Paulo, Brazil. [Wang, Chongying] Nankai Univ, Ctr Behav Sci, Tianjin 300071, Peoples R China. [Wang, Chongying] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China. RP Fombonne, E (reprint author), Montreal Childrens Hosp, Dept Psychiat, 4018 Ste Catherine W, Montreal, PQ H3Z 1P2, Canada. EM eric.fombonne@mcgill.ca RI Psiquiatria, Inct/I-1060-2013 FU WHO; e Shirley Foundation; Autism Speaks; Autistica FX WHO commissioned and supported this review. However, the views expressed in this article do not necessarily represent the decisions, policy, or views of WHO. We appreciate the Shirley Foundation, Autism Speaks, and Autistica for supporting this work. We would like to thank Eileen Hopkins from Autistica, Andy Shih, Michael Rosanoff, and Jessica Napolitano from Autism Speaks and all the professionals and researchers who provided a wealth of information included in the current review. We are also grateful to Rachel Wu for valuable assistance in preparing this article. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Al-Farsi Y., 2010, BRIEF REPORT PREVALE Al-Salehi SM, 2009, TRANSCULT PSYCHIATRY, V46, P340, DOI 10.1177/1363461509105823 American Psychiatric Association, 2000, DIAGN STAT MAN MENT American Psychiatric Association, 1987, DIAGN STAT MAN MENT American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th American Psychiatric Association, 1980, DIAGN STAT MAN MENT Ametepee L., 2009, J INT ASS SPECIAL ED, V10, P11 Arvidsson T., 1997, AUTISM, V1, P163, DOI 10.1177/1362361397012004 Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Bakare MO, 2011, AFR J PSYCHIATRY, V14, P208, DOI [http://dx.doi.org/10.4314/ajpsy.v14i3.3, 10.4314/ajpsy.v14i3.3] Begeer S, 2009, J AUTISM DEV DISORD, V39, P142, DOI 10.1007/s10803-008-0611-5 Belmonte MK, 2004, MOL PSYCHIATR, V9, P646, DOI 10.1038/sj.mp.4001499 Brask B., 1972, NORD S CAR PSYCH CHI BURD L, 1987, J AM ACAD CHILD PSY, V26, P700, DOI 10.1097/00004583-198709000-00014 CDC (Cent. Dis. Control Prev.), 2009, MMWR-MORBID MORTAL W, V58, P1 CDC (Cent. Dis. Control Prev.), 2007, MMWR SURVEILL SUMM, V56, P12 Centers for Disease Control, 2007, MMWR-MORBID MORTAL W, V56, P1 Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133 Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093 Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880 Currenti SA, 2009, CELL MOL NEUROBIOL, V30, P161 Daley TC, 2004, SOC SCI MED, V58, P1323, DOI 10.1016/S0277-9536(03)00330-7 Dealberto MJ, 2011, ACTA PSYCHIAT SCAND, V123, P339, DOI 10.1111/j.1600-0447.2010.01662.x Eapen V, 2007, J TROP PEDIATRICS, V53, P202, DOI 10.1093/tropej/fml091 Eldin AS, 2008, INT REV PSYCHIATR, V20, P281, DOI 10.1080/09540260801990324 Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005 Farley MA, 2009, AUTISM RES, V2, P109, DOI 10.1002/aur.69 Fombonne E., 2003, JAMA-J AM MED ASSOC, V289, P1 Fombonne E., 2011, AUTISM SPECTRUM DISO Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557 Fombonne E., 2005, HDB AUTISM PERVASIVE, P42 Fombonne E, 2006, PEDIATRICS, V118, pE139, DOI 10.1542/peds.2005-2993 Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343 Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672 Ghanizadeh A, 2008, J AUTISM DEV DISORD, V38, P759, DOI 10.1007/s10803-007-0445-6 GILLBERG C, 1995, J INTELL DISABIL RES, V39, P141 GILLBERG C, 1987, BRIT J PSYCHIAT, V150, P856, DOI 10.1192/bjp.150.6.856 GILLBERG C, 1991, BRIT J PSYCHIAT, V158, P403, DOI 10.1192/bjp.158.3.403 Gurney JG, 2003, ARCH PEDIAT ADOL MED, V157, P622, DOI 10.1001/archpedi.157.7.622 Honda H, 2005, J CHILD PSYCHOL PSYC, V46, P572, DOI 10.1111/j.1469-7610.2005.01425.x Honda H, 1996, BRIT J PSYCHIAT, V169, P228, DOI 10.1192/bjp.169.2.228 Icasiano F, 2004, J PAEDIATR CHILD H, V40, P696, DOI 10.1111/j.1440-1754.2004.00513.x Juneja M., 2004, INDIAN PEDIATR, V42, P453 Kalra Veena, 2005, Indian Journal of Pediatrics, V72, P227, DOI 10.1007/BF02859263 Kawamura Y, 2008, PSYCHIAT CLIN NEUROS, V62, P152, DOI 10.1111/j.1440-1819.2008.01748.x Khan N., 1996, Central African Journal of Medicine, V42, P36 Kielinen M, 2000, EUR CHILD ADOLES PSY, V9, P162 Kim YS, 2011, AM J PSYCHIAT, V168, P904, DOI 10.1176/appi.ajp.2011.10101532 Knapp M., 2007, EC CONSEQUENCES AUTI Lazoff T, 2010, CAN J PSYCHIAT, V55, P715 LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363 Lejarraga H, 2008, PAEDIATR PERINAT EP, V22, P180, DOI 10.1111/j.1365-3016.2007.00897.x Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lotter V., 1966, SOC PSYCHIAT, P124, DOI DOI 10.1007/BF00584048 LOTTER V, 1978, J CHILD PSYCHOL PSYC, V19, P231, DOI 10.1111/j.1469-7610.1978.tb00466.x Madsen KM, 2002, NEW ENGL J MED, V347, P1477, DOI 10.1056/NEJMoa021134 Magnusson P, 2001, J AUTISM DEV DISORD, V31, P153, DOI 10.1023/A:1010795014548 Malhi Prahbhjot, 2005, Indian Journal of Pediatrics, V72, P553, DOI 10.1007/BF02724176 Mankoski RE, 2006, J AUTISM DEV DISORD, V36, P1039, DOI 10.1007/s10803-006-0143-9 Montiel-Nava C, 2008, AUTISM, V12, P191, DOI 10.1177/1362361307086663 Murray C. J., 2001, GLOBAL BURDEN DIS 20 Palmer F., 2005, AM J PUBLIC HEALTH, V95, P125 Patel V, 2008, LANCET, V372, P1354, DOI 10.1016/S0140-6736(08)61556-1 Paula CS, 2011, J AUTISM DEV DISORD, V41, P1738, DOI 10.1007/s10803-011-1200-6 Perera H, 2009, J TROP PEDIATRICS, V55, P402, DOI 10.1093/tropej/fmp031 Plubrukarn Ratanotai, 2005, Journal of the Medical Association of Thailand, V88, P891 Powell JE, 2000, DEV MED CHILD NEUROL, V42, P624, DOI 10.1017/S001216220000116X RUTTER M, 1970, SEMIN PSYCHIAT, V2, P435 Samadi SA, 2012, AUTISM, V16, P5, DOI 10.1177/1362361311407091 SCHOPLER E, 1979, J AUTISM DEV DISORD, V9, P139, DOI 10.1007/BF01531530 Singhi P, 2001, Indian Pediatr, V38, P384 Sun X, 2010, RES AUTISM SPECT DIS, V4, P156, DOI 10.1016/j.rasd.2009.10.003 van Balkom IDC, 2009, J NEURODEV DISORD, V1, P197, DOI 10.1007/s11689-009-9011-1 Webb EVJ, 1997, DEV MED CHILD NEUROL, V39, P150 WIGNYOSUMARTO S, 1992, Kobe Journal of Medical Sciences, V38, P1 Williams JG, 2006, ARCH DIS CHILD, V91, P8, DOI 10.1136/adc.2004.062083 WING L, 1976, PSYCHOL MED, V6, P89 WING L, 1980, BRIT J PSYCHIAT, V137, P410, DOI 10.1192/bjp.137.5.410 WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288 Wong VCN, 2008, J CHILD NEUROL, V23, P67, DOI 10.1177/0883073807308702 World Health Organisation, 1992, ICD 10 CLASS MENT BE World Health Organization, 2008, MHGAP MENT HLTH GAP World Health Organization (WHO), 1975, ICD 9 CLASS MENT BEH Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49 Zhang X, 2005, BIOMED ENVIRON SCI, V18, P334 NR 86 TC 157 Z9 163 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2012 VL 5 IS 3 SI SI BP 160 EP 179 DI 10.1002/aur.239 PG 20 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 956EN UT WOS:000305072800003 PM 22495912 ER PT J AU Fombonne, E Marcin, C Bruno, R Tinoco, CM Marquez, CD AF Fombonne, Eric Marcin, Carlos Bruno, Ruth Manero Tinoco, Cecilia Diaz Marquez, Christian TI Screening for Autism in Mexico SO AUTISM RESEARCH LA English DT Article DE epidemiology; screening; autism; cultural; measurement ID PERVASIVE DEVELOPMENTAL DISORDERS; RECIPROCAL SOCIAL-BEHAVIOR; QUANTITATIVE ASSESSMENT; RESPONSIVENESS SCALE; SPECTRUM DISORDERS; CHILDREN; TRAITS; POPULATION; IMPAIRMENT; PREVALENCE AB In order to conduct the screening phase of the first epidemiological survey of autism spectrum disorders (ASDs) in Mexico, we needed a screening tool to detect autistic symptomatology in a large sample of school-age children. We used the Spanish version of the Social Responsiveness Scale (SRS). We recruited a clinical sample of 200 children (81% males; mean age: 7.4?years) with a confirmed diagnosis of ASDs and a sample of 363 control children (59.5% males; mean age: 8.5?years) without ASDs. Three-way analyses of variance (ANOVAs) identified a main effect of clinical status (ASDs vs. controls) for both parent and teacher scales, but no gender or age effect. The mean total and subscale raw scores were significantly different between the clinical and control groups for the parent and for the teacher SRS (P?3.0.CO;2-9 Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008 Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203 FORD RE, 1981, CLIN CHEM, V27, P397 Geier DA, 2009, J TOXICOL ENV HEAL A, V72, P1585, DOI 10.1080/15287390903232475 Kern JK, 2011, PEDIATR INT, V53, P147, DOI 10.1111/j.1442-200X.2010.03196.x Leboyer M, 1999, BIOL PSYCHIAT, V45, P158, DOI 10.1016/S0006-3223(97)00532-5 Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3 LITMAN DA, 1983, SCIENCE, V222, P1031, DOI 10.1126/science.6648517 LITMAN DA, 1985, J PHARMACOL EXP THER, V232, P337 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 MARKS GS, 1985, CRC CR REV TOXICOL, V15, P151, DOI 10.3109/10408448509029323 Nataf R, 2006, TOXICOL APPL PHARM, V214, P99, DOI 10.1016/j.taap.2006.04.008 Owley T, 2003, PSYCHIATRY, P757 Perkins T, 2010, J CLIN NEUROSCI, V17, P1239, DOI 10.1016/j.jocn.2010.01.026 Ratajczak HV, 2011, J IMMUNOTOXICOL, V8, P68, DOI 10.3109/1547691X.2010.545086 Rice Catherine, 2009, Morbidity and Mortality Weekly Report, V58, P1 Rutter M., 2003, ADI R AUTISM DIAGNOS Schopler E., 1988, CARS CHILDHOOD AUTIS Sengupta A, 2005, MOL BRAIN RES, V137, P23, DOI 10.1016/j.molbrainres.2005.02.007 Wall DP, 2009, GENOMICS, V93, P120, DOI 10.1016/j.ygeno.2008.09.015 Woods JS, 2010, ENVIRON HEALTH PERSP, V118, P1450, DOI 10.1289/ehp.0901713 WOODS JS, 1991, TOXICOL APPL PHARM, V110, P464, DOI 10.1016/0041-008X(91)90047-I WOODS JS, 1995, HANDB EXP PHARMACOL, V115, P19 Woods JS, 2009, CLIN CHIM ACTA, V405, P104, DOI 10.1016/j.cca.2009.04.014 Youn SI, 2010, J TOXICOL ENV HEAL A, V73, P701, DOI 10.1080/15287391003614000 NR 35 TC 4 Z9 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2012 VL 5 IS 2 BP 84 EP 92 DI 10.1002/aur.236 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 927KK UT WOS:000302906100002 PM 22298513 ER PT J AU Raznahan, A Lee, Y Vaituzis, C Tran, L Mackie, S Tiemeier, H Clasen, L Lalonde, F Greenstein, D Pierson, R Giedd, JN AF Raznahan, Armin Lee, Yohan Vaituzis, Catherine Tran, Lan Mackie, Susan Tiemeier, Henning Clasen, Liv Lalonde, Francois Greenstein, Dede Pierson, Ron Giedd, Jay N. TI Allelic Variation Within the Putative Autism Spectrum Disorder Risk Gene Homeobox A1 and Cerebellar Maturation in Typically Developing Children and Adolescents SO AUTISM RESEARCH LA English DT Article DE autism; HOXA1; cerebellum; gene; brain; MRI ID HOXA1 A218G POLYMORPHISM; BRAIN-STEM; CORTICAL DEVELOPMENT; INFANTILE-AUTISM; CELL-DEATH; ASSOCIATION; VARIANTS; MR; GROWTH; HOXB1 AB Homeobox A1 (HOXA1) has been proposed as a candidate gene for autism spectrum disorder (ASD) as it regulates embryological patterning of hind-brain structures implicated in autism neurobiology. In line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1A218G (rs10951154)has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood. Despite evidence for early onset and developmentally dynamic cerebellar involvement in ASD, little is known of the relationship between A218G genotype and maturation of the cerebellum over early development. We addressed this issue using 296 longitudinally acquired structural magnetic resonance imaging brain scans from 116 healthy individuals between 5 and 23 years of age. Mixed models were used to compare the relationship between age and semi-automated measures of cerebellar volume in A-homozygotes (AA) and carriers of the G allele (Gcar). Total cerebellar volume increased between ages of 5 and 23 years in both groups. However, this was accelerated in the Gcar relative to the AA group (Genotype-by-age interaction term, P?=?0.03), and driven by genotype-dependent differences in the rate of bilateral superior posterior lobar volume change with age (P?=?0.002). Resultantly, although superior posterior lobar volume did not differ significantly between genotype groups at age 5 (P?=?0.9), by age 23 it was 12% greater in Gcar than AA (P?=?0.002). Our results suggest that common genetic variation within this putative ASD risk gene has the capacity to modify the development of cerebellar systems implicated in ASD neurobiology. C1 [Raznahan, Armin; Lee, Yohan; Vaituzis, Catherine; Tran, Lan; Mackie, Susan; Tiemeier, Henning; Clasen, Liv; Lalonde, Francois; Greenstein, Dede; Pierson, Ron; Giedd, Jay N.] NIMH, Child Psychiat Branch, NIH, Bethesda, MD 20892 USA. [Raznahan, Armin] Kings Coll London, Inst Psychiat, Child Psychiat Dept, London WC2R 2LS, England. RP Raznahan, A (reprint author), NIMH, Child Psychiat Branch, NIH, Bldg 10, Bethesda, MD 20892 USA. EM raznahana@mail.nih.gov RI Raznahan, Armin/F-4534-2012; Giedd, Jay/B-7302-2012 OI Giedd, Jay/0000-0003-0827-3460 FU UK Medical Research Council [G0701370] FX A.R. was funded by the UK Medical Research Council Fellowship (G0701370) while carrying out aspects of this work. A.R. would like to thanks Professors Patrick Bolton, Declan Murphy, and Gareth Barker for their helpful comments on earlier versions of this article. CR Akin ZN, 2005, CELL MOL NEUROBIOL, V25, P697, DOI 10.1007/s10571-005-3971-9 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Canu E, 2009, J NEUROIMAGING, V19, P353, DOI 10.1111/j.1552-6569.2008.00326.x Chakrabarti B, 2009, AUTISM RES, V2, P157, DOI 10.1002/aur.80 Cleavinger HB, 2008, J INT NEUROPSYCH SOC, V14, P401, DOI 10.1017/S1355617708080594 Collins JS, 2003, J AUTISM DEV DISORD, V33, P343, DOI 10.1023/A:1024414803151 Conciatori M, 2004, BIOL PSYCHIAT, V55, P413, DOI 10.1016/j.biopsych.2003.10.005 Courchesne E, 2001, NEUROLOGY, V57, P245 COURCHESNE E, 1994, AM J ROENTGENOL, V162, P123 Devlin B, 2002, AM J MED GENET, V114, P667, DOI 10.1002/ajmg.10603 Fldiss JL, 1986, DESIGN ANAL CLIN EXP FOLSTEIN S, 1977, NATURE, V265, P726, DOI 10.1038/265726a0 Frazer KA, 2009, NAT REV GENET, V10, P241, DOI 10.1038/nrg2554 Giedd JN, 1999, NAT NEUROSCI, V2, P861, DOI 10.1038/13158 Hariri AR, 2003, BRIT MED BULL, V65, P259, DOI 10.1093/bmb/ldg65.259 HASHIMOTO T, 1995, J AUTISM DEV DISORD, V25, P1, DOI 10.1007/BF02178163 Hawkins JR, 2002, HUM MUTAT, V19, P543, DOI 10.1002/humu.10060 Herbeck JT, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006915 Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA Ingram JL, 2000, TERATOLOGY, V62, P393, DOI 10.1002/1096-9926(200012)62:6<393::AID-TERA6>3.0.CO;2-V Kaufmann WE, 2003, J CHILD NEUROL, V18, P463, DOI 10.1177/08830738030180070501 Mackie S, 2007, AM J PSYCHIAT, V164, P647, DOI 10.1176/appi.ajp.164.4.647 Magnotta VA, 2002, COMPUT MED IMAG GRAP, V26, P251, DOI 10.1016/S0895-6111(02)00011-3 MARK M, 1993, DEVELOPMENT, V119, P319 McClintock JM, 2003, DEV GENES EVOL, V213, P399, DOI 10.1007/s00427-003-0335-7 McIntosh AM, 2007, BIOL PSYCHIAT, V61, P1127, DOI 10.1016/j.biopsych.2006.05.020 Meyer-Lindenberg A, 2010, PSYCHOL MED, V40, P1057, DOI 10.1017/S0033291709991929 Mitchell SR, 2009, AM J PSYCHIAT, V166, P917, DOI 10.1176/appi.ajp.2009.08101538 Muscarella LA, 2007, AM J MED GENET B, V144B, P388, DOI 10.1002/ajmg.b.30469 Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287 Paraguison RC, 2007, J NEUROSCI RES, V85, P479, DOI 10.1002/jnr.21137 Paraguison RC, 2005, BIOCHEM BIOPH RES CO, V336, P1033, DOI 10.1016/j.bbrc.2005.08.212 Pierson R, 2002, NEUROIMAGE, V17, P61, DOI 10.1006/nimg.2002.1207 Pinheiro J. C., 2000, MIXED EFFECTS MODELS Posthuma D, 2000, BEHAV GENET, V30, P311, DOI 10.1023/A:1026501501434 Rasalam AD, 2005, DEV MED CHILD NEUROL, V47, P551, DOI 10.1017/S0012162205001076 Raz N, 1998, AM J NEURORADIOL, V19, P65 Raznahan A, 2011, MOL PSYCHIATR, V16, P917, DOI 10.1038/mp.2010.72 Raznahan A, 2011, NEUROIMAGE, V57, P1517, DOI 10.1016/j.neuroimage.2011.05.032 Raznahan A, 2009, J NEURODEV DISORD, V1, P215, DOI 10.1007/s11689-009-9012-0 Rodier PM, 1996, J COMP NEUROL, V370, P247, DOI 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2 Romano V, 2003, MOL PSYCHIATR, V8, P716, DOI 10.1038/sj.mp.4001285 Sen B, 2007, PSYCHIAT GENET, V17, P1, DOI 10.1097/YPG.0b013e328010de0d Shaw P, 2006, NATURE, V440, P676, DOI 10.1038/nature04513 Siegmund KD, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000895 Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006 Talebizadeh Z, 2002, J Med Genet, V39, pe70, DOI 10.1136/jmg.39.11.e70 Tiemeier H, 2010, NEUROIMAGE, V49, P63, DOI 10.1016/j.neuroimage.2009.08.016 Tischfield MA, 2005, NAT GENET, V37, P1035, DOI 10.1038/ng1636 Trainor PA, 2000, NAT REV NEUROSCI, V1, P116, DOI 10.1038/35039056 Wallace GL, 2006, J CHILD PSYCHOL PSYC, V47, P987, DOI 10.1111/j.1469-7610.2006.01676.x Wang VY, 2001, NAT REV NEUROSCI, V2, P484, DOI 10.1038/35081558 Wassink TH, 2007, ARCH GEN PSYCHIAT, V64, P709, DOI 10.1001/archpsyc.64.6.709 Webb SJ, 2009, PSYCHIAT RES-NEUROIM, V172, P61, DOI 10.1016/j.pscychresns.2008.06.001 Yachnis AT, 1999, J CHILD NEUROL, V14, P570, DOI 10.1177/088307389901400904 NR 55 TC 5 Z9 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2012 VL 5 IS 2 BP 93 EP 100 DI 10.1002/aur.238 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 927KK UT WOS:000302906100003 PM 22359339 ER PT J AU Gorrindo, P Williams, KC Lee, EB Walker, LS McGrew, SG Levitt, P AF Gorrindo, Phillip Williams, Kent C. Lee, Evon B. Walker, Lynn S. McGrew, Susan G. Levitt, Pat TI Gastrointestinal Dysfunction in Autism: Parental Report, Clinical Evaluation, and Associated Factors SO AUTISM RESEARCH LA English DT Article DE autism; constipation; diet; functional gastrointestinal disorders; nonverbal communication; social behavior ID CHRONIC ABDOMINAL-PAIN; SPECTRUM DISORDERS; ROME-II; CHILDREN; SYMPTOMS; PREVALENCE; VALIDATION; OBESITY; QUESTIONNAIRE; INDIVIDUALS AB The objectives of this study were to characterize gastrointestinal dysfunction (GID) in autism spectrum disorder (ASD), to examine parental reports of GID relative to evaluations by pediatric gastroenterologists, and to explore factors associated with GID in ASD. One hundred twenty-one children were recruited into three groups: co-occurring ASD and GID, ASD without GID, and GID without ASD. A pediatric gastroenterologist evaluated both GID groups. Parents in all three groups completed questionnaires about their child's behavior and GI symptoms, and a dietary journal. Functional constipation was the most common type of GID in children with ASD (85.0%). Parental report of any GID was highly concordant with a clinical diagnosis of any GID (92.1%). Presence of GID in children with ASD was not associated with distinct dietary habits or medication status. Odds of constipation were associated with younger age, increased social impairment, and lack of expressive language (adjusted odds ratio in nonverbal children: 11.98, 95% confidence interval 2.5456.57). This study validates parental concerns for GID in children with ASD, as parents were sensitive to the existence, although not necessarily the nature, of GID. The strong association between constipation and language impairment highlights the need for vigilance by health-care providers to detect and treat GID in children with ASD. Medications and diet, commonly thought to contribute to GID in ASD, were not associated with GID status. These findings are consistent with a hypothesis that GID in ASD represents pleiotropic expression of genetic risk factors. C1 [Gorrindo, Phillip; Levitt, Pat] Univ So Calif, Zilkha Neurogenet Inst, Keck Sch Med, Los Angeles, CA 90089 USA. [Gorrindo, Phillip] Vanderbilt Univ, Med Scientist Training Program, Nashville, TN USA. [Williams, Kent C.; Lee, Evon B.; Walker, Lynn S.; McGrew, Susan G.] Vanderbilt Univ, Dept Pediat, Nashville, TN USA. [Lee, Evon B.] Vanderbilt Univ, Med Ctr, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN USA. RP Gorrindo, P (reprint author), Univ So Calif, Zilkha Neurogenet Inst, Keck Sch Med, 1501 San Pablo St, Los Angeles, CA 90089 USA. EM phillip.gorrindo@vanderbilt.edu; plevitt@usc.edu FU NICHD [R21HD065289, R01HD23264]; NIGMS [T32GM07347]; NCRR [TL1RR024978, UL1RR024975]; Marino Autism Research Institute; Pediatric Clinical Research Center at Vanderbilt University; Vanderbilt Autism Treatment Network Site; Autism Speaks; NIH FX We are grateful to the families who participated in this study. This work was supported by NICHD Grant R21HD065289 (P. L.), and in part by NIGMS Grant T32GM07347 for the Vanderbilt Medical- Scientist Training Program (P. G.), NCRR Grant TL1RR024978 (P. G.), NICHD Grant R01HD23264 (L. W.), the Vanderbilt Clinical and Translational Science Award UL1RR024975 from NCRR, the Marino Autism Research Institute, the Pediatric Clinical Research Center at Vanderbilt University, and through the Vanderbilt Autism Treatment Network Site, a program funded by Autism Speaks. We are grateful to Loren Tilson for expert managerial oversight and Christianne Lane, PhD for assistance with statistical analysis. Data used in the preparation of this article reside in the NIH-supported National Database for Autism Research, in collection # 1450. This article reflects the views of the authors and does not reflect the opinions or views of the NIH. CR Baber KF, 2008, J PEDIATR GASTR NUTR, V47, P299, DOI 10.1097/MPG.0b013e31816c4372 Bandini LG, 2010, J PEDIATR-US, V157, P259, DOI 10.1016/j.jpeds.2010.02.013 Bauman ML, 2010, NEUROTHERAPEUTICS, V7, P320, DOI 10.1016/j.nurt.2010.06.001 Black C, 2002, BRIT MED J, V325, P419, DOI 10.1136/bmj.325.7361.419 Buie T, 2010, PEDIATRICS, V125, pS1, DOI 10.1542/peds.2009-1878C Campbell DB, 2009, PEDIATRICS, V123, P1018, DOI 10.1542/peds.2008-0819 Caplan A, 2005, J PEDIATR GASTR NUTR, V41, P305, DOI 10.1097/01.mpg.0000172749.71726.13 Caplan A, 2005, J PEDIATR GASTR NUTR, V41, P296, DOI 10.1097/01.mpg.0000172748.64103.33 Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 Constantino JN, 2005, SOCIAL RESPONSIVENES Curtin C, 2010, BMC PEDIATR, V10, DOI 10.1186/1471-2431-10-11 Dhroove G, 2010, J PEDIATR GASTR NUTR, V51, P579, DOI 10.1097/MPG.0b013e3181de0639 Di Lorenzo C, 2005, J PEDIATR GASTR NUTR, V40, P245, DOI 10.1097/01.MPG.0000155367.44628.21 Drossman DA, 2006, GASTROENTEROLOGY, V130, P1377, DOI 10.1053/j.gastro.2006.03.008 Emond A, 2010, PEDIATRICS, V126, pE337, DOI 10.1542/peds.2009-2391 Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010 Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933 Kuczmarski R.J., 2002, VITAL HLTH STAT, V246, P111 LANDIS JR, 1977, BIOMETRICS, V33, P159, DOI 10.2307/2529310 Lord C., 1999, AUTISM DIAGNOSTIC OB Molloy CA, 2003, AUTISM, V7, P165, DOI 10.1177/1362361303007002004 Mouridsen SE, 2010, CHILD CARE HLTH DEV, V36, P437, DOI 10.1111/j.1365-2214.2009.01021.x Nikolov RN, 2009, J AUTISM DEV DISORD, V39, P405, DOI 10.1007/s10803-008-0637-8 Pashankar DS, 2005, PEDIATRICS, V116, pE377, DOI 10.1542/peds.2005-0490 Saps M., 2010, GASTROENTEROLOGY, V138, pS Smith RA, 2009, AUTISM, V13, P343, DOI 10.1177/1362361309106418 Teitelbaum JE, 2009, J PEDIATR-US, V154, P444, DOI 10.1016/j.jpeds.2008.09.053 Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011 Volkmar F. R., 2005, HDB AUTISM PERVASIVE Walker LS, 2000, MANUAL QUESTIONNAIRE Xue Ming, 2008, J Child Neurol, V23, P6 NR 33 TC 28 Z9 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2012 VL 5 IS 2 BP 101 EP 108 DI 10.1002/aur.237 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 927KK UT WOS:000302906100004 PM 22511450 ER PT J AU Goodwin, A Fein, D Naigles, LR AF Goodwin, Anthony Fein, Deborah Naigles, Letitia R. TI Comprehension of Wh-Questions Precedes Their Production in Typical Development and Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE wh-questions; language; grammar; production; comprehension ID EARLY LANGUAGE; WORD-ORDER; COMMUNICATIVE DEVELOPMENT; PREFERENTIAL LOOKING; PRESCHOOL-CHILDREN; INVERSION ERRORS; YOUNG-CHILDREN; EYE-MOVEMENTS; ACQUISITION; FORM AB Children with autism spectrum disorders (ASD) rarely produce wh-questions (e.g. What hit the book?) in naturalistic speech. It is unclear if this is due to socialpragmatic difficulties, or if grammatical deficits are also involved. If grammar is impaired, production of wh-questions by rote memorization might precede comprehension of similar forms. In a longitudinal study, 15 children with ASD and 18 initially language-matched typically developing (TD) toddlers were visited in their homes at 4-month intervals across a 3-year period. The wh-question task was presented via intermodal preferential looking. Silent hitting events (e.g. an apple hitting a flower) were followed by test trials in which the apple and flower were juxtaposed on the screen. During test trials, subject-wh- and object-wh-question audios were sequentially presented (e.g. What hit the flower? or What did the apple hit?). Control audios were also presented (e.g. Where's the apple/flower?). Children's eye movements were coded off-line, frame by frame. To show reliable comprehension, children should look longer to the named item (i.e. apple or flower) during the where questions but less at the named item during the subject-wh and object-wh-questions. To compare comprehension to production, we coded 30-min spontaneous speech samples drawn from motherchild interactions at each visit. Results indicated that comprehension of subject- and object-wh-questions was delayed in children with ASD compared with age-matched TD children, but not when matched on overall language levels. Additionally, both groups comprehended wh-questions before producing similar forms, indicating that development occurred in a similar manner. This paper discusses the implications of our findings for language acquisition in ASD. C1 [Goodwin, Anthony; Fein, Deborah; Naigles, Letitia R.] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA. RP Goodwin, A (reprint author), Univ Connecticut, Dept Psychol, 406 Babbidge Rd,Unit 1020, Storrs, CT 06269 USA. EM anthony.goodwin@uconn.edu FU National Institute on Deafness and Other Communication Disorders [R01 DC007428] FX This research was funded by a grant from the National Institute on Deafness and Other Communication Disorders (PI: Letitia Naigles; Grant number: R01 DC007428). We are grateful to Rose Jaffery and Janina Piotroski for assistance in stimulus creation and data collection, and to the undergraduates of the UConn Child Language Lab for coding and transcribing. We thank George Hollich for sharing the wh-question video with us, andWendy Stone for making the STAT available to us. We appreciate the helpful commentary received from Jeff Lidz, Lisa Edelson, and attendants at the International Meeting for Autism Research (IMFAR), Boston University Conference on Language Development (BUCLD) and the Society for Research on Child Development (SRCD) biennial meetings. Finally, many thanks are due to the children and families who participated in our study. CR ALLEN DA, 1992, INT CONGR SER, V965, P157 Ambridge B, 2006, J CHILD LANG, V33, P519, DOI 10.1017/S0305000906007513 Arias-Trejo N, 2010, J EXP CHILD PSYCHOL, V105, P63, DOI 10.1016/j.jecp.2009.10.002 BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 BLOOM L, 1982, CHILD DEV, V53, P1084, DOI 10.1111/j.1467-8624.1982.tb01374.x Botwinik-Rotem I., 2009, HDB CHILD LANGUAGE D, P144 Brandone A., 2007, METHODS COGNITIVE LI, P345 Chan A, 2010, COGNITIVE DEV, V25, P30, DOI 10.1016/j.cogdev.2009.10.002 CHAPMAN RS, 1975, J SPEECH HEAR RES, V18, P355 Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482 CLARK P, 1981, J AUTISM DEV DISORD, V11, P201, DOI 10.1007/BF01531685 Dapretto M, 2000, CHILD DEV, V71, P635, DOI 10.1111/1467-8624.00172 DEVILLIERS J, 1990, STUD TH PSY, V10, P257 De Villiers J, 2008, APPL PSYCHOLINGUIST, V29, P67, DOI 10.1017/S0142716408080041 Edelson L., 2008, INT M AUT RES LOND Eigsti I. M., 2009, J CHILD LANG, V19, P1 Eigsti IM, 2007, J AUTISM DEV DISORD, V37, P1007, DOI 10.1007/s10803-006-0239-2 Fein D., 1996, PRESCHOOL CHILDREN I, P123 Fenson L., 1994, MONOGRAPHS SOC RES C, V59, P14 Fletcher P., 1995, HDB CHILD LANGUAGE, P508 GERKEN L, 1993, DEV PSYCHOL, V29, P448, DOI 10.1037/0012-1649.29.3.448 Gerken L.A., 1996, METHODS ASSESSING CH, P125 Gertner Y, 2006, PSYCHOL SCI, V17, P684, DOI 10.1111/j.1467-9280.2006.01767.x GOLINKOFF RM, 1987, J CHILD LANG, V14, P23 Goodwin A., 2009, INT M AUT RES CHIC I Hawkins JA, 1999, LANGUAGE, V75, P244, DOI 10.2307/417261 Hewitt LE, 1998, J COMMUN DISORD, V31, P135, DOI 10.1016/S0021-9924(97)00086-5 Hirsh-Pasek K., 1996, ORIGINS GRAMMAR EVID Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899 Huttenlocher J., 1974, THEORIES COGNITIVE P, P331 Ivar Lovaas O., 1987, J CONSULT CLIN PSYCH, V55, P3, DOI DOI 10.1037//0022-006X.55.13 Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287 Kukona A, 2011, COGNITIVE SCI, V35, P1009, DOI 10.1111/j.1551-6709.2011.01180.x Lord C., 1999, AUTISM DIAGNOSTIC OB Luyster R, 2007, J CHILD LANG, V34, P623, DOI 10.1017/S0305000907008094 MALZONE D, 1979, J PSYCHOLINGUIST RES, V8, P21, DOI 10.1007/BF01067128 Maratsos M., 1998, HDB CHILD PSYCHOL, V2, P421 Mesite L., 2011, BOST U C LANG DEV BO Mitchell S, 2006, J DEV BEHAV PEDIATR, V27, pS69, DOI 10.1097/00004703-200604002-00004 Mullen E.M., 1995, MULLEN SCALES INFANT Muller RA, 1999, J AUTISM DEV DISORD, V29, P19, DOI 10.1023/A:1025914515203 Naigles LR, 2002, COGNITION, V86, P157, DOI 10.1016/S0010-0277(02)00177-4 Naigles LR, 1996, COGNITION, V58, P221, DOI 10.1016/0010-0277(95)00681-8 Naigles LR, 2011, AUTISM RES, V4, P422, DOI 10.1002/aur.223 Oi M, 2010, CLIN LINGUIST PHONET, V24, P691, DOI 10.3109/02699206.2010.488313 Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x Piotroski J., 2011, RES METHODS CHILD LA, P17 Quirk Randolph, 1985, COMPREHENSIVE GRAMMA Rowland CF, 2000, J CHILD LANG, V27, P157, DOI 10.1017/S0305000999004055 Rutter M., 1978, AUTISM REAPPRAISAL C, P1 SCARBOROUGH HS, 1991, APPL PSYCHOLINGUIST, V12, P23, DOI 10.1017/S014271640000936X Searle J., 1969, SPEECH ACTS ESSAY PH Seidl A, 2003, INFANCY, V4, P423, DOI 10.1207/S15327078IN0403_06 Smith ME, 1933, CHILD DEV, V4, P201 Snyder William, 2007, CHILD LANGUAGE PARAM Sparrow SS, 2005, VINELAND ADAPTIVE BE Stone WL, 2000, J AUTISM DEV DISORD, V30, P607, DOI 10.1023/A:1005647629002 Stromswold K, 1995, LANG ACQUIS, V4, P5, DOI 10.1207/s15327817la0401&2_1 Sussman RS, 2003, LANG COGNITIVE PROC, V18, P143, DOI 10.1080/01690960143000498 Swensen LD, 2007, CHILD DEV, V78, P542, DOI 10.1111/j.1467-8624.2007.01022.x Swingley D., 2011, RES METHODS CHILD LA, P29 Tager-Flusberg H, 2004, DEVELOPMENTAL LANGUAGE DISORDERS: FROM PHENOTYPES TO ETIOLOGIES, P31 TAGERFLUSBERG H, 1990, J AUTISM DEV DISORD, V20, P1, DOI 10.1007/BF02206853 TAGERFLUSBERG H, 1990, J CHILD LANG, V17, P591 TAGERFLUSBERG H, 1994, CONSTRAINTS LANGUAGE Tek S., 2008, AUTISM RES, V1, P202 TYACK D, 1977, J CHILD LANG, V4, P211 Venker C.E., 2011, INT M AUT RES SAN DI Wagner L, 2009, COGNITIVE DEV, V24, P223, DOI 10.1016/j.cogdev.2009.05.001 Weismer SE, 2010, J AUTISM DEV DISORD, V40, P1259, DOI 10.1007/s10803-010-0983-1 WETHERBY AM, 1984, J SPEECH HEAR RES, V27, P364 Wetherby Amy M., 2000, AUTISM SPECTRUM DISO, P109 Wynn JW, 2003, BEHAV INTERVENT, V18, P245, DOI 10.1002/bin.142 NR 73 TC 12 Z9 12 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2012 VL 5 IS 2 BP 109 EP 123 DI 10.1002/aur.1220 PG 15 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 927KK UT WOS:000302906100005 PM 22359403 ER PT J AU Izawa, J Pekny, SE Marko, MK Haswell, CC Shadmehr, R Mostofsky, SH AF Izawa, Jun Pekny, Sarah E. Marko, Mollie K. Haswell, Courtney C. Shadmehr, Reza Mostofsky, Stewart H. TI Motor Learning Relies on Integrated Sensory Inputs in ADHD, but Over-Selectively on Proprioception in Autism Spectrum Conditions SO AUTISM RESEARCH LA English DT Article DE motor learning; internal model; generalization ID HIGH-FUNCTIONING AUTISM; INTERNAL-MODELS; DIAGNOSTIC INTERVIEW; SUBTLE SIGNS; CHILDREN; ADAPTATION; DISORDERS; DYNAMICS; ABNORMALITIES; IMITATION AB The brain builds an association between action and sensory feedback to predict the sensory consequence of self-generated motor commands. This internal model of action is central to our ability to adapt movements and may also play a role in our ability to learn from observing others. Recently, we reported that the spatial generalization patterns that accompany adaptation of reaching movements were distinct in children with autism spectrum disorder (ASD) as compared with typically developing (TD) children. To test whether the generalization patterns are specific to ASD, here, we compared the patterns of adaptation with those in children with attention deficit hyperactivity disorder (ADHD). Consistent with our previous observations, we found that in ASD, the motor memory showed greater than normal generalization in proprioceptive coordinates compared with both TD children and children with ADHD; children with ASD also showed slower rates of adaptation compared with both control groups. Children with ADHD did not show this excessive generalization to the proprioceptive target, but they did show excessive variability in the speed of movements with an increase in the exponential distribution of responses (t) as compared with both TD children and children with ASD. The results suggest that slower rate of adaptation and anomalous bias towards proprioceptive feedback during motor learning are characteristics of autism, whereas increased variability in execution is a characteristic of ADHD. Autism Res 2012,:. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Izawa, Jun; Pekny, Sarah E.; Marko, Mollie K.; Haswell, Courtney C.; Shadmehr, Reza] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA. [Izawa, Jun] ATR Computat Neurosci Labs, Kyoto, Japan. [Mostofsky, Stewart H.] Kennedy Krieger Inst, Baltimore, MD USA. [Mostofsky, Stewart H.] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA. [Mostofsky, Stewart H.] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA. RP Izawa, J (reprint author), 2-2-2 Hikaridai, Seika, Kyoto 6190288, Japan. EM jizawa@atr.jp RI Izawa, Jonathan/C-1111-2015 FU Autism Speaks Foundation; NIH [R01 NS048527, MH078160, MH085328, NS37422]; Johns Hopkins University School of Medicine Institute for Clinical and Translational Research; NIH/NCRR CTSA [UL1-RR025005]; SRPBS(MEXT); [JSPS23700360] FX This research was supported by grants from the Autism Speaks Foundation and from NIH: R01 NS048527, MH078160, MH085328, NS37422, the Johns Hopkins University School of Medicine Institute for Clinical and Translational Research, an NIH/NCRR CTSA Program, UL1-RR025005, SRPBS(MEXT), and JSPS23700360. CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th BAUMAN ML, 1991, PEDIATRICS, V87, P791 Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004 Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5 Cattaneo L, 2007, P NATL ACAD SCI USA, V104, P17825, DOI 10.1073/pnas.0706273104 Cole WR, 2008, NEUROLOGY, V71, P1514, DOI 10.1212/01.wnl.0000334275.57734.5f Conners C. K., 1997, CONNERS RATING SCALE Constantino JN, 2005, SOCIAL RESPONSIVENES COURCHESNE E, 1994, AM J ROENTGENOL, V162, P123 Criscimagna-Hemminger SE, 2008, J NEUROSCI, V28, P9610, DOI 10.1523/JNEUROSCI.3071-08.2008 Darainy M, 2009, J NEUROPHYSIOL, V101, P3158, DOI 10.1152/jn.91336.2008 DENCKLA MB, 1985, PSYCHOPHARMACOL BULL, V21, P773 Dewey D, 2007, J INT NEUROPSYCH SOC, V13, P246, DOI 10.1017/S1355617707070270 Donchin O, 2003, J NEUROSCI, V23, P9032 Dowell LR, 2009, NEUROPSYCHOLOGY, V23, P563, DOI 10.1037/a0015640 DuPaul GJ, 1998, ADHD RATING SCALE 4 Dziuk MA, 2007, DEV MED CHILD NEUROL, V49, P734 Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9 Galea J., 2010, CEREB CORTEX, V21, P1761 Geurts HM, 2008, NEUROPSYCHOLOGIA, V46, P3030, DOI 10.1016/j.neuropsychologia.2008.06.013 Harris CM, 1998, NATURE, V394, P780, DOI 10.1038/29528 Haswell CC, 2009, NAT NEUROSCI, V12, P970, DOI 10.1038/nn.2356 Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032 Hwang EJ, 2006, EXP BRAIN RES, V169, P496, DOI 10.1007/s00221-005-0163-2 Hwang EJ, 2005, J NEURAL ENG, V2, DOI 10.1088/1741-2560/2/3/S09 Izawa J, 2008, J NEUROSCI, V28, P2883, DOI 10.1523/JNEUROSCI.5359-07.2008 Izawa J, 2011, PLOS COMPUT BIOL, V7, DOI 10.1371/journal.pcbi.1002012 Jansiewicz EM, 2006, J AUTISM DEV DISORD, V36, P613, DOI 10.1007/s10803-006-0109-y Kates WR, 1998, ANN NEUROL, V43, P782, DOI 10.1002/ana.410430613 Keisler A, 2010, J NEUROSCI, V30, P14817, DOI 10.1523/JNEUROSCI.4160-10.2010 Klin A, 2003, PHILOS T ROY SOC B, V358, P345, DOI 10.1098/rstb.2002.1202 Kording KP, 2007, NAT NEUROSCI, V10, P779, DOI 10.1038/nn1901 Krakauer JW, 2006, PLOS BIOL, V4, P1798, DOI 10.1371/journal.pbio.0040316 Lang CE, 1999, J NEUROPHYSIOL, V82, P2108 Larson JCG, 2008, BRAIN, V131, P2894, DOI 10.1093/brain/awn226 Leth-Steensen C, 2000, ACTA PSYCHOL, V104, P167, DOI 10.1016/S0001-6918(00)00019-6 Lord C., 1999, AUTISM DIAGNOSTIC OB LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 MacNeil LK, 2011, NEUROLOGY, V76, P622, DOI 10.1212/WNL.0b013e31820c3052 Malfait N, 2005, J NEUROPHYSIOL, V93, P3327, DOI 10.1152/jn.00883.2004 Malfait N, 2002, J NEUROSCI, V22, P9656 Mattar AAG, 2010, J NEUROPHYSIOL, V104, P426, DOI 10.1152/jn.00886.2009 Mattar AAG, 2005, NEURON, V46, P153, DOI 10.1016/j.neuron.2005.02.009 Miall RC, 2003, NEUROREPORT, V14, P2135, DOI 10.1097/01.wnr.0000098751.87269.77 Mostofsky SH, 2006, J INT NEUROPSYCH SOC, V12, P314, DOI 10.1017/S1355617706060437 Mostofsky SH, 2007, BRAIN, V130, P2117, DOI 10.1093/brain/awm129 Mostofsky SH, 2003, PERCEPT MOTOR SKILL, V97, P1315, DOI 10.2466/PMS.97.8.1315-1331 Mottron L, 2004, J AUTISM DEV DISORD, V34, P19, DOI 10.1023/B:JADD.0000018070.88380.83 Ochipa C, 1997, NEUROLOGY, V49, P474 Poggio T, 2004, NATURE, V431, P768, DOI 10.1038/nature03014 RATCLIFF R, 1993, PSYCHOL BULL, V114, P510, DOI 10.1037/0033-2909.114.3.510 Reich W., 1997, DIAGNOSTIC INTERVIEW Reich W, 2000, J AM ACAD CHILD PSY, V39, P59, DOI 10.1097/00004583-200001000-00017 Rizzolatti G, 2002, CURR OPIN NEUROBIOL, V12, P149, DOI 10.1016/S0959-4388(02)00308-2 Rizzolatti G, 2001, NAT REV NEUROSCI, V2, P661, DOI 10.1038/35090060 Rogers SJ, 1996, CHILD DEV, V67, P2060, DOI 10.2307/1131609 Scheidt RA, 2000, J NEUROPHYSIOL, V84, P853 Shadmehr R, 2000, J NEUROSCI, V20, P7807 Shadmehr R, 2008, EXP BRAIN RES, V185, P359, DOI 10.1007/s00221-008-1280-5 Shadmehr R, 2004, HUM MOVEMENT SCI, V23, P543, DOI 10.1016/j.humov.2004.04.003 Smith MA, 2006, PLOS BIOL, V4, P1035, DOI 10.1371/journal.pbio.0040179 Synofzik M, 2008, CURR BIOL, V18, P814, DOI 10.1016/j.cub.2008.04.071 Tanaka H, 2009, J NEUROPHYSIOL, V102, P2921, DOI 10.1152/jn.90834.2008 Thoroughman KA, 2000, NATURE, V407, P742 Vaurio RG, 2009, NEUROPSYCHOLOGIA, V47, P2389, DOI 10.1016/j.neuropsychologia.2009.01.022 Wechsler D., 2003, WECHSLER INTELLIGENC NR 67 TC 27 Z9 27 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2012 VL 5 IS 2 BP 124 EP 136 DI 10.1002/aur.1222 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 927KK UT WOS:000302906100006 PM 22359275 ER PT J AU Sacco, R Lenti, C Saccani, M Curatolo, P Manzi, B Bravaccio, C Persico, AM AF Sacco, Roberto Lenti, Carlo Saccani, Monica Curatolo, Paolo Manzi, Barbara Bravaccio, Carmela Persico, Antonio M. TI Cluster Analysis of Autistic Patients Based on Principal Pathogenetic Components SO AUTISM RESEARCH LA English DT Article DE pervasive developmental disorders; cluster analysis; immune system; neurodevelopment; principal component analysis ID PERVASIVE DEVELOPMENTAL DISORDERS; SPECTRUM DISORDERS; PHENOTYPIC VARIATION; BEHAVIOR PROFILES; SUBTYPES; CHILDREN; ABNORMALITIES; SUBGROUPS; TODDLERS; BRAIN AB We have recently described four principal pathogenetic components in autism: (I) circadian and sensory dysfunction, (II) immune abnormalities, (III) neurodevelopmental delay, and (IV) stereotypic behaviors. Using hierarchical and k-means clustering, the same 245 patients assessed in our principal component analysis can be partitioned into four clusters: (a) 43 (17.6%) have prominent immune abnormalities accompanied by some circadian and sensory issues; (b) 44 (18.0%) display major circadian and sensory dysfunction, with little or no immune symptoms; (c) stereotypies predominate in 75 (31.0%); and (d) 83 (33.9%) show a mixture of all four components, with greater disruptive behaviors and mental retardation. The immune component provides the largest contributions to phenotypic variance (P?=?2.7?x?1045), followed by stereotypic behaviors. These patient clusters may likely differ in genetic and immune underpinnings, developmental trajectories, and response to treatment. Autism Res 2012,:. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Sacco, Roberto; Persico, Antonio M.] Univ Campus Biomed, Lab Mol Psychiat & Neurogenet, I-00128 Rome, Italy. [Sacco, Roberto; Persico, Antonio M.] IRCCS Fdn Santa Lucia, Rome, Italy. [Lenti, Carlo; Saccani, Monica] Univ Milan, Dept Child Neuropsychiat, Milan, Italy. [Curatolo, Paolo; Manzi, Barbara] Univ Tor Vergata, Dept Child Neuropsychiat, Rome, Italy. [Bravaccio, Carmela] Univ Naples Federico 2, Dept Pediat, Naples, Italy. RP Persico, AM (reprint author), Univ Campus Biomed, Lab Mol Psychiat & Neurogenet, Via Alvaro del Portillo 21, I-00128 Rome, Italy. EM a.persico@unicampus.it FU Italian Ministry for University, Scientific Research and Technology [2006058195, 2008BACT54_002]; Italian Ministry of Health [RFPS-2007-5-640174]; Fondazione Gaetano e Mafalda Luce (Milan, Italy); Autism Speaks (Princeton, New Jersey) [7376]; Autism Research Institute (San Diego, CA) FX The authors gratefully acknowledge all the families who participated in this study. Maurizio Elia, Marina Gandione, Raun Melmed, Roberto Militerni, Roberto Rigardetto, and Cindy Schneider contributed to recruiting the patient sample. This work was supported by the Italian Ministry for University, Scientific Research and Technology (PRIN n. 2006058195 and n. 2008BACT54_002), the Italian Ministry of Health (RFPS-2007-5-640174), the Fondazione Gaetano e Mafalda Luce (Milan, Italy), Autism Speaks (Princeton, New Jersey) (7376) and the Autism Research Institute (San Diego, CA). These results were presented at the 9th Annual International Meeting for Autism Research held in Philadelphia on May 20-22, 2010. CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Arango C, 2010, EUR CHILD ADOLES PSY, V19, P627, DOI 10.1007/s00787-010-0123-7 BALOTTIN U, 1989, J AUTISM DEV DISORD, V19, P109, DOI 10.1007/BF02212722 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x Bitsika V, 2008, J INTELL DISABIL RES, V52, P973, DOI 10.1111/j.1365-2788.2008.01123.x Bruining H, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010887 Bruining H., 2010, PLOS ONE, V5, P1 Buxbaum Joseph D, 2009, Dialogues Clin Neurosci, V11, P35 Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x Doetschman Thomas, 2009, V530, P423, DOI 10.1007/978-1-59745-471-1_23 Duda R. O., 2001, PATTERN CLASSIFICATI EAVES LC, 1994, J AUTISM DEV DISORD, V24, P3, DOI 10.1007/BF02172209 Fein D, 1999, CHILD NEUROPSYCHOL, V5, P1, DOI 10.1076/chin.5.1.1.7075 Garon N, 2009, J ABNORM CHILD PSYCH, V37, P59, DOI 10.1007/s10802-008-9258-0 Goines P, 2010, CURR OPIN NEUROL, V23, P111, DOI 10.1097/WCO.0b013e3283373514 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Hair JF, 1995, MULTIVARIATE DATA AN HAMEURY L, 1995, EUR CHILD ADOLES PSY, V4, P123 Hrdlicka M, 2005, EUR CHILD ADOLES PSY, V14, P138, DOI 10.1007/s00787-005-0453-z Hu VW, 2009, AUTISM RES, V2, P67, DOI 10.1002/aur.72 Kim SH, 2012, J CHILD PSYCHOL PSYC, V53, P143, DOI 10.1111/j.1469-7610.2011.02458.x Lane AE, 2011, J AUTISM DEV DISORD, V41, P826, DOI 10.1007/s10803-010-1103-y Lintas C, 2009, J MED GENET, V46, P1, DOI 10.1136/jmg.2008.060871 Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021 Lord C, 2002, ADOS AUTISM DIAGNOST Luyster R, 2009, J AUTISM DEV DISORD, V39, P1305, DOI 10.1007/s10803-009-0746-z Malvy J, 2004, EUR CHILD ADOLES PSY, V13, P115, DOI 10.1007/s00787-004-0374-2 Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016 Persico A.M., 2012, COMPREHENSI IN PRESS Piven J, 1997, AM J PSYCHIAT, V154, P185 Prior M, 1998, J CHILD PSYCHOL PSYC, V39, P893, DOI 10.1111/1469-7610.00389 Ring H., 2008, BEHAV BRAIN FUNCT, V4:11, P1 Roux S, 1997, BIOL PSYCHIAT, V42, P1148, DOI 10.1016/S0006-3223(96)00469-6 Roux S, 1995, EUR CHILD ADOLES PSY, V4, P249 Rutter M., 2003, ADI R AUTISM DIAGNOS Sacco R, 2010, AUTISM RES, V3, P237, DOI 10.1002/aur.151 Saresella M, 2009, BIOL PSYCHIAT, V66, P978, DOI 10.1016/j.biopsych.2009.06.020 Sevin JA, 1995, J AUTISM DEV DISORD, V25, P561, DOI 10.1007/BF02178188 SHAM PC, 1995, ANN HUM GENET, V59, P97, DOI 10.1111/j.1469-1809.1995.tb01608.x Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846 SIEGEL B, 1986, J AUTISM DEV DISORD, V16, P275, DOI 10.1007/BF01531660 Snow AV, 2009, J CHILD PSYCHOL PSYC, V50, P734, DOI 10.1111/j.1469-7610.2008.02018.x Sparrow S, 1984, VINELAND ADAPTIVE BE Spiker D, 2002, AM J MED GENET, V114, P129, DOI 10.1002/ajmg.10188 Stevens MC, 2000, J AM ACAD CHILD PSY, V39, P346, DOI 10.1097/00004583-200003000-00017 TABACHNICK BARBARA G., 1989, USING MULTIVARIATE S, V2d Tadevosyan-Leyfer O, 2003, J AM ACAD CHILD PSY, V42, P864, DOI 10.1097/01.CHI.0000046870.56865.90 van Lang NDJ, 2006, J CHILD PSYCHOL PSYC, V47, P37, DOI 10.1111/j.1469-7610.2005.01434.x Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315 Wiggins LD, 2012, J AUTISM DEV DISORD, V42, P191, DOI 10.1007/s10803-011-1230-0 WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288 Wolf U, 1997, HUM GENET, V100, P305, DOI 10.1007/s004390050509 NR 53 TC 10 Z9 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2012 VL 5 IS 2 BP 137 EP 147 DI 10.1002/aur.1226 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 927KK UT WOS:000302906100007 PM 22431251 ER PT J AU Warren, Z Vehorn, A Dohrmann, E Nicholson, A Sutcliffe, JS Veenstra-VanderWeele, J AF Warren, Zachary Vehorn, Alison Dohrmann, Elizabeth Nicholson, Amy Sutcliffe, James S. Veenstra-VanderWeele, Jeremy TI Accuracy of Phenotyping Children With Autism Based on Parent Report: What Specifically Do We Gain Phenotyping "Rapidly"? (vol 5, pg 3, 2011) SO AUTISM RESEARCH LA English DT Correction RI Sutcliffe, James/C-1348-2012 OI Sutcliffe, James/0000-0001-5200-6007 CR WARREN Z, 2011, AUTISM RES, V5, P3 NR 1 TC 0 Z9 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2012 VL 5 IS 2 BP 151 EP 151 DI 10.1002/aur.1228 PG 1 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 927KK UT WOS:000302906100008 ER PT J AU Bailey, AJ AF Bailey, Anthony J. TI Autism in adults SO AUTISM RESEARCH LA English DT Editorial Material C1 [Bailey, Anthony J.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. RP Bailey, AJ (reprint author), BC Mental Hlth & Addict Res Unit, A3-121,938 W 28th Ave, Vancouver, BC V5Z 4H4, Canada. EM anthony.bailey@ubc.ca RI Bailey, Anthony/J-2860-2014 OI Bailey, Anthony/0000-0003-4257-972X NR 0 TC 3 Z9 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2012 VL 5 IS 1 BP 1 EP 2 DI 10.1002/aur.233 PG 2 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 900FG UT WOS:000300871400001 PM 22162402 ER PT J AU Murphy, CM Deeley, Q Daly, EM Ecker, C O'Brien, FM Hallahan, B Loth, E Toal, F Reed, S Hales, S Robertson, DM Craig, MC Mullins, D Barker, GJ Lavender, T Johnston, P Murphy, KC Murphy, DG AF Murphy, Clodagh M. Deeley, Q. Daly, E. M. Ecker, C. O'Brien, F. M. Hallahan, B. Loth, E. Toal, F. Reed, S. Hales, S. Robertson, D. M. Craig, M. C. Mullins, D. Barker, G. J. Lavender, T. Johnston, P. Murphy, K. C. Murphy, D. G. TI Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome SO AUTISM RESEARCH LA English DT Article DE Asperger syndrome; autism; amygdala; hippocampus; age ID HIGH-FUNCTIONING AUTISM; POSITRON-EMISSION-TOMOGRAPHY; MEDIAL TEMPORAL-LOBE; FUSIFORM FACE AREA; SOCIAL-BEHAVIOR; STEREOLOGICAL ESTIMATION; BRAIN-DEVELOPMENT; CHRONIC STRESS; VOLUME; SEROTONIN AB It has been proposed that people with autism spectrum disorder (ASD) have abnormal morphometry and development of the amygdala and hippocampus (AH). However, previous reports are inconsistent, perhaps because they included people of different ASD diagnoses, ages, and health. We compared, using magnetic resonance imaging, the in vivo anatomy of the AH in 32 healthy individuals with Asperger syndrome (1247 years) and 32 healthy controls who did not differ significantly in age or IQ. We measured bulk (gray + white matter) volume of the AH using manual tracing (MEASURE). We first compared the volume of AH between individuals with Asperger syndrome and controls and then investigated age-related differences. We compared differences in anatomy before, and after, correcting for whole brain size. There was no significant between group differences in whole brain volume. However, individuals with Asperger syndrome had a significantly larger raw bulk volume of total (P<0.01), right (P<0.01), and left amygdala (P<0.05); and when corrected for overall brain size, total (P<0.05), and right amygdala (P<0.01). There was a significant group difference in aging of left amygdala; controls, but not individuals with Asperger syndrome, had a significant age-related increase in volume (r = 0.486, P<0.01, and r = 0.007, P = 0.97, z = 1.995). There were no significant group differences in volume or age-related effects in hippocampus. Individuals with Asperger syndrome have significant differences from controls in bulk volume and aging of the amygdala. Autism Res 2012,5:312. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Murphy, Clodagh M.; Deeley, Q.; Daly, E. M.; Ecker, C.; Hallahan, B.; Loth, E.; Toal, F.; Reed, S.; Hales, S.; Robertson, D. M.; Craig, M. C.; Mullins, D.; Lavender, T.; Johnston, P.; Murphy, D. G.] Kings Coll London, Dept Forens & Neurodev Sci, Inst Psychiat, London SE5 8AF, England. [O'Brien, F. M.; Murphy, K. C.] Royal Coll Surgeons Ireland, Dublin 2, Ireland. [Barker, G. J.] Kings Coll London, Dept Clin Neurosci, Inst Psychiat, Ctr Neuroimaging Sci, London SE5 8AF, England. RP Murphy, CM (reprint author), Kings Coll London, Dept Forens & Neurodev Sci, Inst Psychiat, De Crespigny Pk,POB 50,Denmark Hill, London SE5 8AF, England. EM clodagh.m.murphy@kcl.ac.uk RI Barker, Gareth/C-9616-2009; Murphy, Kieran/D-3577-2012; Ecker, Christine/E-5194-2010 OI Barker, Gareth/0000-0002-5214-7421; FU Medical Research Council (MRC UK); Medical Research Council FX We thank all the individuals and their families who participated in this study and our colleagues for their help in recruiting subjects. This study was supported by a grant from the Medical Research Council (MRC UK A.I.M.S research program). None of the authors reported any financial interests or potential conflicts of interests associated with this study. The authors declare no conflict of interest.Grant sponsor: Medical Research Council. CR Abell F, 1999, NEUROREPORT, V10, P1647, DOI 10.1097/00001756-199906030-00005 Adolphs R, 2003, ANN NY ACAD SCI, V985, P326 Amaral David G., 2003, Neuropsychologia, V41, P517, DOI 10.1016/S0028-3932(02)00310-X Amaral DG, 2003, ANN NY ACAD SCI, V1000, P337, DOI 10.1196/annanls.1280.015 Ashwin C, 2007, NEUROPSYCHOLOGIA, V45, P2, DOI 10.1016/j.neuropsychologia.2006.04.014 Aylward EH, 1999, NEUROLOGY, V53, P2145 BACHEVALIER J, 1994, NEUROPSYCHOLOGIA, V32, P627, DOI 10.1016/0028-3932(94)90025-6 Bannerman DM, 2004, NEUROSCI BIOBEHAV R, V28, P273, DOI 10.1016/j.neubiorev.2004.03.004 Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7 Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x Barta PE, 1997, J NEUROSCI METH, V75, P111, DOI 10.1016/S0165-0270(97)00049-6 BARTKO JJ, 1976, J NERV MENT DIS, V163, P307, DOI 10.1097/00005053-197611000-00003 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Baxter MG, 2002, NAT REV NEUROSCI, V3, P563, DOI 10.1038/nrn875 Bigler ED, 2003, AM J NEURORADIOL, V24, P2066 Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9 Cody H, 2002, INT J DEV NEUROSCI, V20, P421, DOI 10.1016/S0736-5748(02)00053-9 Craig MC, 2007, BRIT J PSYCHIAT, V191, P224, DOI 10.1192/bjp.bp.106.034603 Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203 Cutter WJ, 2006, BIOL PSYCHIAT, V59, P273, DOI 10.1016/j.biopsych.2005.06.026 Dalton KM, 2007, BIOL PSYCHIAT, V61, P512, DOI 10.1016/j.biopsych.2006.05.019 DAMASIO AR, 1978, ARCH NEUROL-CHICAGO, V35, P777 Davis M, 2003, ANN NY ACAD SCI, V985, P218 Deeley Q, 2007, BIOL PSYCHIAT, V62, P207, DOI 10.1016/j.biopsych.2006.09.037 Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010 Ecker C, 2010, NEUROIMAGE, V49, P44, DOI 10.1016/j.neuroimage.2009.08.024 Endo T, 2007, BIOL PSYCHIAT, V62, P1030, DOI 10.1016/j.biopsych.2007.05.015 Giedd JN, 1996, J COMP NEUROL, V366, P223, DOI 10.1002/(SICI)1096-9861(19960304)366:2<223::AID-CNE3>3.0.CO;2-7 Goldberg J, 2009, J AUTISM DEV DISORD, V39, P97, DOI 10.1007/s10803-008-0604-4 Gottfried JA, 2003, SCIENCE, V301, P1104, DOI 10.1126/science.1087919 Grelotti DJ, 2005, NEUROPSYCHOLOGIA, V43, P373, DOI 10.1016/j.neuropsychologia.2004.06.015 Grieve SM, 2005, HUM BRAIN MAPP, V25, P391, DOI 10.1002/hbm.20115 Groen W, 2010, J AM ACAD CHILD PSY, V49, P552, DOI 10.1016/j.jaac.2009.12.023 Grunwald T, 1998, P NATL ACAD SCI USA, V95, P3193, DOI 10.1073/pnas.95.6.3193 HAUG JS, 1994, BBA-MOL CELL RES, V1223, P133, DOI 10.1016/0167-4889(94)90082-5 Haxby JV, 2002, BIOL PSYCHIAT, V51, P59, DOI 10.1016/S0006-3223(01)01330-0 Haznedar MM, 2000, AM J PSYCHIAT, V157, P1994, DOI 10.1176/appi.ajp.157.12.1994 Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110 Holland PC, 2004, CURR OPIN NEUROBIOL, V14, P148, DOI 10.1016/j.conb.2004.03.007 Howard MA, 2000, NEUROREPORT, V11, P2931, DOI 10.1097/00001756-200009110-00020 Kluver H, 1939, ARCH NEURO PSYCHIATR, V42, P979 LeDoux J, 2003, CELL MOL NEUROBIOL, V23, P727, DOI 10.1023/A:1025048802629 Liu RSN, 2003, NEUROIMAGE, V20, P22, DOI 10.1016/S1053-8119(03)00219-2 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Maguire EA, 2000, P NATL ACAD SCI USA, V97, P4398, DOI 10.1073/pnas.070039597 McAlonan GM, 2009, PSYCHOL MED, V39, P1885, DOI 10.1017/S0033291709005728 McAlonan GM, 2008, J CHILD PSYCHOL PSYC, V49, P1287, DOI 10.1111/j.1469-7610.2008.01933.x McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006 McGaugh JL, 2004, ANNU REV NEUROSCI, V27, P1, DOI 10.1146/annurev.neuro.27.070203.144157 Mosconi MW, 2009, ARCH GEN PSYCHIAT, V66, P509, DOI 10.1001/archgenpsychiatry.2009.19 Murphy DGM, 2006, AM J PSYCHIAT, V163, P934, DOI 10.1176/appi.ajp.163.5.934 Murphy DGM, 1996, ARCH GEN PSYCHIAT, V53, P585 Nacewicz BM, 2006, ARCH GEN PSYCHIAT, V63, P1417, DOI 10.1001/archpsyc.63.12.1417 Nicolson R, 2006, PSYCHIAT RES-NEUROIM, V148, P11, DOI 10.1016/j.pscychresns.2006.02.005 Otsuka H, 1999, NEURORADIOLOGY, V41, P517 Page LA, 2006, AM J PSYCHIAT, V163, P2189, DOI 10.1176/appi.ajp.163.12.2189 Pallant J. F., 2005, SPSS SURVIVAL MANUAL Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287 Palmen SJMC, 2005, PSYCHOL MED, V35, P1411, DOI 10.1017/S0033291705005015 Palmen SJMC, 2006, PSYCHOL MED, V36, P827, DOI 10.1017/S0033291706007215 Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059 Piven J, 1998, J AUTISM DEV DISORD, V28, P105, DOI 10.1023/A:1026084430649 Pruessner JC, 2001, J NEUROSCI, V21, P194 Raymond GV, 1996, ACTA NEUROPATHOL, V91, P117 Raz N, 2005, CEREB CORTEX, V15, P1676, DOI 10.1093/cercor/bhi044 Raznahan A, 2009, PSYCHIAT GENET, V19, P147, DOI 10.1097/YPG.0b013e32832a505a Richardson MP, 2004, NAT NEUROSCI, V7, P278, DOI 10.1038/nn1190 Rojas DC, 2004, AM J PSYCHIAT, V161, P2038, DOI 10.1176/appi.ajp.161.11.2038 ROSVOLD HE, 1954, J COMP PHYSIOL PSYCH, V47, P173, DOI 10.1037/h0058870 Saitoh O, 2001, BRAIN, V124, P1317, DOI 10.1093/brain/124.7.1317 Salmond CH, 2005, EUR J NEUROSCI, V22, P764, DOI 10.1111/j.1460-9568.2005.04217.x Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004 Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006 Schumann CM, 2005, J COMP NEUROL, V491, P320, DOI 10.1002/cne.20704 Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007 Sparks BF, 2002, NEUROLOGY, V59, P184 Suzuki M, 2005, CEREB CORTEX, V15, P187, DOI 10.1093/cercor/bhh121 Sweeten TL, 2002, PHARMACOL BIOCHEM BE, V71, P449, DOI 10.1016/S0091-3057(01)00697-9 Van Amelsvoort T, 2001, BRIT J PSYCHIAT, V178, P412 VarghaKhadem F, 1997, SCIENCE, V277, P376, DOI 10.1126/science.277.5324.376 Vyas A, 2003, BRAIN RES, V965, P290, DOI 10.1016/S0006-8993(02)04162-8 Vyas A, 2002, J NEUROSCI, V22, P6810 Wassink TH, 2007, ARCH GEN PSYCHIAT, V64, P709, DOI 10.1001/archpsyc.64.6.709 WATSON C, 1992, NEUROLOGY, V42, P1743 Weschler D, 1999, WESCHLER ABBREVIATED WEST MJ, 1991, ANAT REC, V231, P482, DOI 10.1002/ar.1092310411 Whitaker-Azmitia PM, 2001, BRAIN RES BULL, V56, P479, DOI 10.1016/S0361-9230(01)00615-3 White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003 World Health Organisation, 1994, ICD 10 CLASS MENT BE NR 91 TC 8 Z9 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2012 VL 5 IS 1 BP 3 EP 12 DI 10.1002/aur.227 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 900FG UT WOS:000300871400002 PM 21948742 ER PT J AU Bernier, R Gerdts, J Munson, J Dawson, G Estes, A AF Bernier, Raphael Gerdts, Jennifer Munson, Jeff Dawson, Geraldine Estes, Annette TI Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families SO AUTISM RESEARCH LA English DT Article DE broader autism phenotype; autism spectrum disorders; genetics; autism assessment ID CHILDREN; SPECTRUM; HISTORY; TRAITS; AGGREGATION; DISORDERS; RELATIVES; PROBANDS; MODELS; TWIN AB The broader autism phenotype (BAP) was assessed in parents who have two or more children with autism spectrum disorder (ASD) (multiplex (MPX) autism), parents who have no more than one child with ASD (simplex autism), parents who have a child with developmental delay without ASD, and parents who have typically developing children. Clinicians, naive to parent group membership status, rated BAP characteristics from videotaped administration of the Broader Autism Phenotype Symptom Scale (BPASS). Differences among groups in BPASS scores in the four assessed domains (social motivation, conversational skills, expressiveness, and restricted interests) were examined using multivariate ANOVA and post hoc comparisons. Further, ratings of videotapes by observers naive to family status were compared with live, non-naive ratings by observers who were aware of family status (non-naive). Findings demonstrate that the BPASS is an instrument resistant to rater bias. Parents from MPX autism families showed significantly more autism phenotype characteristics than the parents in the other groups. Moreover, the parents from simplex autism families did not differ from the parents of children with developmental delay or typical development. Finally, no differences between live, non-naive ratings and videotaped, naive ratings were observed. These findings suggest that characteristics of the BAP, specifically in the social and communication domains, are present in MPX autism parents to a greater degree than simplex autism and control parents. Further, the results provide support for the notion that genetic transmission mechanisms may differ between families with more than one child with autism and families with only one child with autism. Autism Res 2012,5:1320. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Estes, Annette] Univ Washington, Ctr Human Dev & Disabil, Dept Psychol, Seattle, WA 98195 USA. [Bernier, Raphael; Munson, Jeff] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Estes, Annette] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA. [Dawson, Geraldine] Autism Speaks, New York, NY 10016 USA. RP Estes, A (reprint author), Univ Washington, Ctr Human Dev & Disabil, Dept Psychol, Box 357920, Seattle, WA 98195 USA. EM estesa@u.washington.edu FU National Institute Health [HD35465, HD055782] FX Grant sponsor: National Institute Health; Grant numbers: HD35465; HD055782. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th BAILEY A, 1995, PSYCHOL MED, V25, P63 BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548 Berrettini Wade H, 2005, Dialogues Clin Neurosci, V7, P95 Bolte S, 2003, PSYCHOL MED, V33, P907, DOI 10.1017/S0033291703007438 BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2 Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271 Dawson G, 2005, DEV PSYCHOPATHOL, V17, P679, DOI 10.1017/S0954579405050327 Dawson G, 2007, J AUTISM DEV DISORD, V37, P523, DOI 10.1007/s10803-006-0182-2 Di Michele V., 2007, J TREATMENT EVALUATI, V4, P144 Elliot C. D., 1990, DIFFERENTIAL ABILITY Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658 FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x Gottesman II, 2003, AM J PSYCHIAT, V160, P636, DOI 10.1176/appi.ajp.160.4.636 Gould TD, 2006, GENES BRAIN BEHAV, V5, P113, DOI 10.1111/j.1601-183X.2005.00186 LANDA R, 1992, PSYCHOL MED, V22, P245 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Losh M, 2007, J CHILD PSYCHOL PSYC, V48, P105, DOI 10.1111/j.1469-7610.2006.01594.x Losh M, 2008, AM J MED GENET B, V147B, P424, DOI 10.1002/ajmg.b.30612 Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 Mullen E, 1995, MULLEN SCALES EARLY Pickles A, 2000, J CHILD PSYCHOL PSYC, V41, P491, DOI 10.1017/S0021963099005557 Piven J, 1997, AM J MED GENET, V74, P398, DOI 10.1002/(SICI)1096-8628(19970725)74:4<398::AID-AJMG11>3.0.CO;2-D Piven J, 1997, AM J PSYCHIAT, V154, P185 Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e Ruser TF, 2007, J AUTISM DEV DISORD, V37, P1323, DOI 10.1007/s10803-006-0274-z Schellenberg GD, 2006, MOL PSYCHIATR, V11, P1049, DOI 10.1038/sj.mp.4001874 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 Sung YJ, 2005, AM J HUM GENET, V76, P68, DOI 10.1086/426951 Szatmari P, 2000, J CHILD PSYCHOL PSYC, V41, P579, DOI 10.1017/S0021963099005831 Virkud YV, 2009, AM J MED GENET B, V150B, P328, DOI 10.1002/ajmg.b.30810 Wechsler D, 1997, WECHSLER ADULT INTEL, V3rd Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974 NR 35 TC 14 Z9 15 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2012 VL 5 IS 1 BP 13 EP 20 DI 10.1002/aur.226 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 900FG UT WOS:000300871400003 PM 21905246 ER PT J AU Lyall, K Pauls, DL Spiegelman, D Ascherio, A Santangelo, SL AF Lyall, Kristen Pauls, David L. Spiegelman, Donna Ascherio, Alberto Santangelo, Susan L. TI Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the nurses' health study II SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; gestational diabetes; obstetric complications; pregnancy complications ID PERINATAL RISK-FACTORS; ASPERGER-SYNDROME; INFANTILE-AUTISM; AUTOIMMUNE-DISEASES; BIRTH COMPLICATIONS; NEONATAL FACTORS; POPULATION; PSYCHOPATHOLOGY; CHILDHOOD; HISTORY AB The authors examined pregnancy and obstetric complications in association with autism spectrum disorders (ASD) in children of participants from the Nurses' Health Study II, a prospective national cohort with information collected through biennial mailed questionnaires since 1989. Logistic regression was used to obtain crude and adjusted odds ratios for ASD, and by diagnostic subgroup. Seven hundred and ninety-three cases were reported among 66,445 pregnancies. Pregnancy complications and obstetric suboptimality factors were assessed by maternal report of occurrence in first birth and, in secondary analyses, in any birth. Complications and a suboptimality score were significantly associated with having a child with ASD (OR 1.49, 95% CI 1.26, 1.77, P<0.0001 for pregnancy complications in first birth and 2.76, 95% CI 2.04, 3.74, P<0.0001 comparing individuals with four or more obstetric suboptimality factors in first birth to those with none; results similar when assessed in any birth). In particular, gestational diabetes was associated with a significantly increased risk of ASD in results of primary and sensitivity analyses (OR in primary analysis = 1.76, 95% CI 1.34, 2.32, P<0.0001); suboptimal parity and suboptimal age-at-first-birth were also individual factors associated with ASD. Associations were similar by diagnostic subgroup, suggesting autism, Asperger syndrome, and other Pervasive Developmental Disorders are all associated with pregnancy complications. Consistent with previous research, the general class of pregnancy complications was associated with ASD as a whole. Additional work will be required to more fully assess the role of gestational diabetes. Autism Res 2012,5:2130. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Lyall, Kristen; Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Lyall, Kristen; Pauls, David L.; Spiegelman, Donna; Ascherio, Alberto; Santangelo, Susan L.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Spiegelman, Donna] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Pauls, David L.; Santangelo, Susan L.] Harvard Univ, Sch Publ Hlth, Dept Psychiat, Boston, MA 02115 USA. [Pauls, David L.; Santangelo, Susan L.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Ctr Human Genet Res, Boston, MA 02114 USA. [Ascherio, Alberto] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Ascherio, Alberto] Harvard Univ, Sch Med, Channing Lab, Boston, MA 02115 USA. RP Lyall, K (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, 655 Huntington Ave, Boston, MA 02115 USA. EM klyall@hsph.harvard.edu FU NHS II; NIH [R01-CA50385]; Autism Speaks [1788, 2210]; United States Department of Defense (DOD) and Army Medical Research and Material Command (USAMRMC) [A-14917] FX The authors would like to thank the participants of the NHS II, as well as the funding organizations for their support. Funding organizations have reviewed and approved the design and conduct of the overall NHS II, but were not involved in the collection, management, analysis, or interpretation of the data; nor were they involved in the preparation, review, or approval of this manuscript.Grant sponsor: NIH; Grant number: R01-CA50385; Grant sponsor: Autism Speaks; Grant numbers: 1788; 2210; Grant sponsor: United States Department of Defense (DOD) and Army Medical Research and Material Command (USAMRMC); Grant number: A-14917. CR Atladottir HO, 2009, PEDIATRICS, V124, P687, DOI 10.1542/peds.2008-2445 Bhasin T., 2006, J AUTISM DEV DISORD, V37, P667 Bolton PF, 1997, J AM ACAD CHILD PSY, V36, P272, DOI 10.1097/00004583-199702000-00018 Brimacombe M, 2007, MATERN CHILD HLTH J, V11, P73, DOI 10.1007/s10995-006-0142-7 Burd L, 1999, J PERINAT MED, V27, P441, DOI 10.1515/JPM.1999.059 Center for Disease and Control Prevention, 2006, MORBIDITY MORTALITY, V17, P481 Colditz GA, 1997, J WOMENS HEALTH, V6, P49, DOI 10.1089/jwh.1997.6.49 Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950 Croen LA, 2005, ARCH PEDIAT ADOL MED, V159, P151, DOI 10.1001/archpedi.159.2.151 DURRLEMAN S, 1989, STAT MED, V8, P551, DOI 10.1002/sim.4780080504 Eaton WW, 2001, J AUTISM DEV DISORD, V31, P279, DOI 10.1023/A:1010743203048 FARAONE SV, 1995, J AM ACAD CHILD PSY, V34, P1001, DOI 10.1097/00004583-199508000-00009 Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672 Gardener H, 2009, EPIDEMIOLOGY, V20, P611, DOI 10.1097/EDE.0b013e31819ed4b9 Ghaziuddin M, 1995, J INTELL DISABIL RES, V39, P538 GILLBERG C, 1989, DEV MED CHILD NEUROL, V31, P520 Gillberg C, 2005, J AUTISM DEV DISORD, V35, P159, DOI 10.1007/s10803-005-1993-2 GILLBERG C, 1983, J AUTISM DEV DISORD, V13, P153, DOI 10.1007/BF01531816 Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618 Govindarajulu US, 2007, STAT MED, V26, P3735, DOI 10.1002/sim.2848 Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6 Hunt KJ, 2007, OBSTET GYN CLIN N AM, V34, P173, DOI 10.1016/j.ogc.2007.03.002 Juul-Dam N, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.4.e63 Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326 Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123 Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x LORD C, 1991, J AUTISM DEV DISORD, V21, P197, DOI 10.1007/BF02284760 Maimburg RD, 2006, ACTA PSYCHIAT SCAND, V114, P257, DOI 10.1111/j.1600-0447.2006.00805.x Miettinen OS, 1985, THEORETICAL EPIDEMIO PIVEN J, 1993, J AM ACAD CHILD PSY, V32, P1256, DOI 10.1097/00004583-199311000-00021 Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026 Sasanfar R, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-2 Stein D, 2006, COMPR PSYCHIAT, V47, P69, DOI 10.1016/j.comppsych.2005.01.001 Tarin JJ, 1998, HUM REPROD, V13, P2371, DOI 10.1093/humrep/13.9.2371 Tomeo CA, 1999, EPIDEMIOLOGY, V10, P774, DOI 10.1097/00001648-199911000-00022 Wallace AE, 2008, J AUTISM DEV DISORD, V38, P1542, DOI 10.1007/s10803-007-0536-4 Weinberg C., 1998, MODERN EPIDEMIOLOGY, P585 Zwaigenbaum L, 2002, J AM ACAD CHILD PSY, V41, P572, DOI 10.1097/00004583-200205000-00015 NR 38 TC 10 Z9 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2012 VL 5 IS 1 BP 21 EP 30 DI 10.1002/aur.228 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 900FG UT WOS:000300871400004 PM 21972225 ER PT J AU Warren, Z Vehorn, A Dohrmann, E Nicholson, A Sutcliffe, JS Veenstra-VanderWeele, J AF Warren, Zachary Vehorn, Alison Dohrmann, Elizabeth Nicholson, Amy Sutcliffe, James S. Veenstra-VanderWeele, Jeremy TI Accuracy of Phenotyping Children With Autism Based on Parent Report: What Specifically Do We Gain Phenotyping "Rapidly"? SO AUTISM RESEARCH LA English DT Article DE Autism; ASD; genetic studies; rapid phenotyping ID DISORDERS; GENETICS; IDENTIFICATION; ABNORMALITIES; INDIVIDUALS; RESOURCE AB Autism spectrum disorder (ASD) is considered among the most heritable of all neurodevelopmental and psychiatric disorders, but identification of etiologically significant genetic markers and risk variants has been hampered by a lack of sufficiently large samples. Rapid phenotyping procedures, where self-report measures are used instead of extensive clinical assessment, have been proposed as methods for amassing large genetic databases due to their hypothesized time-efficiency and affordability. We assessed the diagnostic accuracy of potential rapid phenotyping procedures using the Social Communication Questionnaire and the Social Responsiveness Scale in a sample of 333 children who also received extensive phenotypic assessments. While the rapid phenotyping measures were able to accurately identify a large number of children with ASD, they also frequently failed to differentiate children with ASD from children with other complex neurobehavioral profiles. These data support the continued need of expert clinical validation in combination with rapid phenotyping procedures in order to accurately amass large-scale genetic collections of children with ASD. Autism Res 2012,5:31-38. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Warren, Zachary; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Pediat, Nashville, TN 37203 USA. [Warren, Zachary; Nicholson, Amy; Sutcliffe, James S.; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37203 USA. [Warren, Zachary; Vehorn, Alison; Dohrmann, Elizabeth; Nicholson, Amy; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Vanderbilt Kennedy Ctr Treatment & Res Inst Austi, Nashville, TN 37203 USA. [Sutcliffe, James S.] Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37203 USA. [Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37203 USA. RP Warren, Z (reprint author), Vanderbilt Univ, Vanderbilt Kennedy Ctr TRIAD, PMB 74,230 Appleton Pl, Nashville, TN 37203 USA. EM zachary.warren@vanderbilt.edu RI Sutcliffe, James/C-1348-2012 OI Sutcliffe, James/0000-0001-5200-6007 FU Simons Foundation FX This study was supported by a grant from the Simons Foundation (Simons Simplex Collection) awarded to J.S. We are grateful to the families who took part for their assistance and partnership as well as to the research team who assisted in this endeavor: Nicola Gillan, Morgan Kaminski, Bryant Duda, Rebecca Johnston, Evon Lee, Courtney Burnette, Cassandra Newsom, Julie Crittendon, Whitney Loring. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Betancur C, 2011, BRAIN RES, V1380, P42, DOI 10.1016/j.brainres.2010.11.078 Butcher JN, 1989, MINNESOTA MULTIPHASI Centers for Disease Control and Prevention, 2009, MMWR-MORBID MORTAL W, V58, P1 Constantino JN, 2005, SOCIAL RESPONSIVENES Corsello C, 2007, J CHILD PSYCHOL PSYC, V48, P932, DOI 10.1111/j.1469-7610.2007.01762.x Devlin B, 2011, BRAIN RES, V1380, P78, DOI 10.1016/j.brainres.2010.11.026 Elliott C., 2007, DIFFERENTIAL ABILITY Fischbach GD, 2010, NEURON, V68, P192, DOI 10.1016/j.neuron.2010.10.006 Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x Ganz ML, 2007, ARCH PEDIAT ADOL MED, V161, P343, DOI 10.1001/archpedi.161.4.343 Gotham K, 2007, J AUTISM DEV DISORD, V37, P400, DOI DOI 10.1007/S10803-006-0280-1 Lajonchere CM, 2010, NEURON, V68, P187, DOI 10.1016/j.neuron.2010.10.009 Lee H, 2010, AM J MED GENET B, V153B, P1119, DOI 10.1002/ajmg.b.31103 Lord C, 2000, J AUTISM DEV DISORD, V18, P505 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Mullen E, 1995, MULLEN SCALES EARLY Norris M, 2010, AUTISM, V14, P263, DOI 10.1177/1362361309348071 O'Roak BJ, 2008, AUTISM RES, V1, P4, DOI 10.1002/aur.3 Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 Reynolds C. R., 2002, CLIN GUIDE BEHAV ASS Rutter M., 2003, SOCIAL COMMUNICATION Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 Sparrow SS, 2005, VINELAND ADAPTIVE BE Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 Virkud YV, 2009, AM J MED GENET B, V150B, P328, DOI 10.1002/ajmg.b.30810 Vorstman JAS, 2006, MOL PSYCHIATR, V11, P18, DOI 10.1038/sj.mp.4001757 Wassink TH, 2001, PSYCHIATR GENET, V11, P57, DOI 10.1097/00041444-200106000-00001 Wechsler D., 2003, WISC 4 TECHNICAL INT NR 29 TC 4 Z9 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2012 VL 5 IS 1 BP 31 EP 38 DI 10.1002/aur.230 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 900FG UT WOS:000300871400005 PM 21972233 ER PT J AU Megnin, O Flitton, A Jones, CRG de Haan, M Baldeweg, T Charman, T AF Megnin, Odette Flitton, Atlanta Jones, Catherine R. G. de Haan, Michelle Baldeweg, Torsten Charman, Tony TI Audiovisual Speech Integration in Autism Spectrum Disorders: ERP Evidence for Atypicalities in Lexical-Semantic Processing SO AUTISM RESEARCH LA English DT Article DE auditory; ASD; ERP; language; multisensory; visual ID EVENT-RELATED POTENTIALS; HUMAN AUDITORY-CORTEX; CHILDREN; PERCEPTION; BRAIN; COMPREHENSION; ACTIVATION; MIND; INCONGRUITY; REPETITION AB In typically developing (TD) individuals, behavioral and event-related potential (ERP) studies suggest that audiovisual (AV) integration enables faster and more efficient processing of speech. However, little is known about AV speech processing in individuals with autism spectrum disorders (ASD). This study examined ERP responses to spoken words to elucidate the effects of visual speech (the lip movements accompanying a spoken word) on the range of auditory speech processing stages from sound onset detection to semantic integration. The study also included an AV condition, which paired spoken words with a dynamic scrambled face in order to highlight AV effects specific to visual speech. Fourteen adolescent boys with ASD (15-17 years old) and 14 age- and verbal IQ-matched TD boys participated. The ERP of the TD group showed a pattern and topography of AV interaction effects consistent with activity within the superior temporal plane, with two dissociable effects over frontocentral and centroparietal regions. The posterior effect (200-300 ms interval) was specifically sensitive to lip movements in TD boys, and no AV modulation was observed in this region for the ASD group. Moreover, the magnitude of the posterior AV effect to visual speech correlated inversely with ASD symptomatology. In addition, the ASD boys showed an unexpected effect (P2 time window) over the frontocentral region (pooled electrodes F3, Fz, F4, FC1, FC2, FC3, FC4), which was sensitive to scrambled face stimuli. These results suggest that the neural networks facilitating processing of spoken words by visual speech are altered in individuals with ASD. Autism Res2012, 5 :39-48. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Megnin, Odette; Flitton, Atlanta] UCL Inst Child Hlth, Behav & Brain Sci Unit, London, England. [Charman, Tony] Univ London, Inst Educ, Ctr Res Autism & Educ, London WC1N 1AZ, England. [Jones, Catherine R. G.] Univ Essex, Dept Psychol, Colchester CO4 3SQ, Essex, England. [de Haan, Michelle; Baldeweg, Torsten] UCL Inst Child Hlth, Dev Cognit Neurosci Unit, London, England. RP Megnin, O (reprint author), Royal Coll Psychiatrists, Natl Collaborating Ctr Mental Hlth, Standon House,21 Mansell St, London E1 8AA, England. EM omegnin@cru.rcpsych.ac.uk RI Jones, Catherine/E-4956-2013; Charman, Tony/A-2085-2014 OI Charman, Tony/0000-0003-1993-6549 FU MRC; Autism Speaks [1280] FX Grant sponsor: MRC, Autism Speaks; Grant number: 1280 CR Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Bebko JM, 2006, J CHILD PSYCHOL PSYC, V47, P88, DOI 10.1111/j.1469-7610.2005.01443.x Belin P, 2000, NATURE, V403, P309, DOI 10.1038/35002078 Belin P, 2003, NEUROREPORT, V14, P2105, DOI 10.1097/00001756-200311140-00019 BENTIN S, 1985, ELECTROEN CLIN NEURO, V60, P343, DOI 10.1016/0013-4694(85)90008-2 Besle J, 2004, EUR J NEUROSCI, V20, P2225, DOI 10.1111/j.1460-9568.2004.03670.x Bonda E, 1996, J NEUROSCI, V16, P3737 Bonte M, 2006, CEREB CORTEX, V16, P115, DOI 10.1093/cercor/bhi091 BROWN GD, 1984, BEHAV RES METH INS C, V16, P502, DOI 10.3758/BF03200836 Calvert GA, 1997, SCIENCE, V276, P593, DOI 10.1126/science.276.5312.593 Castelli F, 2000, NEUROIMAGE, V12, P314, DOI 10.1006/nimg.2000.0612 Ceponiene R, 2005, PSYCHOPHYSIOLOGY, V42, P391, DOI 10.1111/j.1469-8986.2005.00305.x De Gelder B, 1991, EUROPEAN J COGNITIVE, V3, P69, DOI 10.1080/09541449108406220 DOMALSKI P, 1991, PSYCHOL SCI, V2, P173, DOI 10.1111/j.1467-9280.1991.tb00126.x Dunn M, 1999, DEV NEUROPSYCHOL, V16, P79, DOI 10.1207/S15326942DN160105 Dunn MA, 2005, J AUTISM DEV DISORD, V35, P361, DOI 10.1007/s10803-005-3304-3 Frith U., 1983, BRIT J DEV PSYCHOL, V1, P329, DOI 10.1111/j.2044-835X.1983.tb00906.x Happe FGE, 1997, BRIT J DEV PSYCHOL, V15, P1 Harris GJ, 2006, BRAIN COGNITION, V61, P54, DOI 10.1016/j.bandc.2005.12.015 Howard RJ, 1996, CURR BIOL, V6, P1015, DOI 10.1016/S0960-9822(02)00646-2 Iarocci G, 2010, AUTISM, V14, P305, DOI 10.1177/1362361309353615 Klucharev V, 2003, COGNITIVE BRAIN RES, V18, P65, DOI 10.1016/j.cogbrainres.2003.09.004 KUTAS M, 1980, SCIENCE, V207, P203, DOI 10.1126/science.7350657 Kutas M, 2000, TRENDS COGN SCI, V4, P463, DOI 10.1016/S1364-6613(00)01560-6 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 MacSweeney M, 2000, NEUROREPORT, V11, P1729, DOI 10.1097/00001756-200006050-00026 Magnee MJCM, 2008, J CHILD PSYCHOL PSYC, V49, P995, DOI 10.1111/j.1469-7610.2008.01902.x MCGURK H, 1976, NATURE, V264, P746, DOI 10.1038/264746a0 McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x Norbury CF, 2005, BRIT J DEV PSYCHOL, V23, P383, DOI 10.1348/026151005X26732 OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225 PAUL R, 1985, J SPEECH HEAR RES, V28, P475 Pulvermuller F, 2009, BRAIN LANG, V110, P81, DOI 10.1016/j.bandl.2008.12.001 Ring H, 2007, J AUTISM DEV DISORD, V37, P281, DOI 10.1007/s10803-006-0167-1 RUGG MD, 1985, PSYCHOPHYSIOLOGY, V22, P642, DOI 10.1111/j.1469-8986.1985.tb01661.x Rutter M., 2003, SOCIAL COMMUNICATION Sanders LD, 2002, NAT NEUROSCI, V5, P700, DOI 10.1038/nn873 Schultz J, 2004, J COGNITIVE NEUROSCI, V16, P1695, DOI 10.1162/0898929042947874 SEMLITSCH HV, 1986, PSYCHOPHYSIOLOGY, V23, P695, DOI 10.1111/j.1469-8986.1986.tb00696.x Smith EG, 2007, J CHILD PSYCHOL PSYC, V48, P813, DOI 10.1111/j.1469-7610.2007.01766.x SNOWLING M, 1986, J EXP CHILD PSYCHOL, V42, P392, DOI 10.1016/0022-0965(86)90033-0 Stein B. E., 1993, MERGING SENSES Stekelenburg JJ, 2007, J COGNITIVE NEUROSCI, V19, P1964, DOI 10.1162/jocn.2007.19.12.1964 STRANDBURG RJ, 1993, NEUROPSYCHOLOGIA, V31, P413, DOI 10.1016/0028-3932(93)90058-8 TAGERFLUSBERG H, 1991, BRIT J DEV PSYCHOL, V9, P417 van Wassenhove V, 2005, P NATL ACAD SCI USA, V102, P1181, DOI 10.1073/pnas.0408949102 Wechsler D, 1999, WASI MANUAL Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008 Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004 NR 50 TC 5 Z9 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2012 VL 5 IS 1 BP 39 EP 48 DI 10.1002/aur.231 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 900FG UT WOS:000300871400006 PM 22162387 ER PT J AU Duerden, EG Mak-Fan, KM Taylor, MJ Roberts, SW AF Duerden, Emma G. Mak-Fan, Kathleen M. Taylor, Margot J. Roberts, S. Wendy TI Regional Differences in Grey and White Matter in Children and Adults With Autism Spectrum Disorders: An Activation Likelihood Estimate (ALE) Meta-analysis SO AUTISM RESEARCH LA English DT Article DE structural MRI; pediatrics ID VOXEL-BASED MORPHOMETRY; HIGH-FUNCTIONING AUTISM; MEDIAL TEMPORAL-LOBE; FALSE DISCOVERY RATE; CORPUS-CALLOSUM; GRAY-MATTER; ASPERGERS-SYNDROME; BRAIN OVERGROWTH; ALZHEIMERS-DISEASE; CORTICAL THICKNESS AB Structural alterations in brain morphology have been inconsistently reported in children compared to adults with autism spectrum disorder (ASD). We assessed these differences by performing meta-analysis on the data from 19 voxel-based morphometry studies. Common findings across the age groups were grey matter reduction in left putamen and medial prefrontal cortex (mPFC) and grey matter increases in the lateral PFC, while white matter decreases were seen mainly in the children in frontostriatal pathways. In the ASD sample, children/adolescents were more likely than adults to have increased grey matter in bilateral fusiform gyrus, right cingulate and insula. Results show that clear maturational differences exist in social cognition and limbic processing regions only in children/adolescents and not in adults with ASD, and may underlie the emotional regulation that improves with age in this population. Autism Res 2012,5:49-66. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Duerden, Emma G.; Roberts, S. Wendy] Hosp Sick Children, Autism Res Unit, Toronto, ON M5G 1X8, Canada. [Duerden, Emma G.; Mak-Fan, Kathleen M.; Taylor, Margot J.] Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON M5G 1X8, Canada. [Roberts, S. Wendy] Holland Bloorview Kids Rehabil Ctr, Toronto, ON, Canada. [Mak-Fan, Kathleen M.; Taylor, Margot J.; Roberts, S. Wendy] Univ Toronto, Toronto, ON, Canada. RP Duerden, EG (reprint author), Hosp Sick Children, Autism Res Unit, 555 Univ Ave, Toronto, ON M5G 1X8, Canada. EM emma.duerden@sickkids.ca FU Hospital for Sick Children; Reva Gerstein Fellowship in Paediatric Psychology; CIHR [MOP 81611] FX The authors thank Hannah Oatley (Hospital for Sick Children) for help with data entry. This research was supported in part by a Fellowship from the Hospital for Sick Children (E.G.D.), and the Reva Gerstein Fellowship in Paediatric Psychology (E.G.D.) and CIHR (MOP 81611) to M.J.T.Grant sponsor: Hospital for Sick Children, and the Reva Gerstein Fellowship in Paediatric Psychology, CIHR; Grant number: MOP 81611. CR Abell F, 1999, NEUROREPORT, V10, P1647, DOI 10.1097/00001756-199906030-00005 ALEXANDER GE, 1986, ANNU REV NEUROSCI, V9, P357, DOI 10.1146/annurev.ne.09.030186.002041 Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005 Anagnostou E, 2011, MOL AUTISM, V2, DOI 10.1186/2040-2392-2-4 Apkarian AV, 2005, EUR J PAIN, V9, P463, DOI 10.1016/j.ejpain.2004.11.001 Ashtari M, 2007, NEUROIMAGE, V35, P501, DOI 10.1016/j.neuroimage.2006.10.047 Aylward EH, 1999, NEUROLOGY, V53, P2145 Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022 BAUMAN M, 1985, NEUROLOGY, V35, P866 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Becker A, 1999, PSYCHOPHARMACOLOGY, V144, P333, DOI 10.1007/s002130051015 Becker A, 2000, BEHAV BRAIN RES, V109, P137, DOI 10.1016/S0166-4328(99)00163-1 BENES FM, 1989, SCHIZOPHRENIA BULL, V15, P585 Bennetto L, 1996, CHILD DEV, V67, P1816, DOI 10.1111/j.1467-8624.1996.tb01830.x Bigler ED, 2010, DEV NEUROPSYCHOL, V35, P278, DOI 10.1080/87565641003696817 Bloss CS, 2007, J AM ACAD CHILD PSY, V46, P515, DOI 10.1097/chi.0b013e318030e28b Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016 Bonilha L, 2008, BRAIN DEV-JPN, V30, P396, DOI 10.1016/j.braindev.2007.11.006 Brieber S, 2007, J CHILD PSYCHOL PSYC, V48, P1251, DOI 10.1111/j.1469-7610.2007.01799.x Bright P, 2006, LEARN MEMORY, V13, P545, DOI 10.1101/lm.265906 Busatto GF, 2003, NEUROBIOL AGING, V24, P221, DOI 10.1016/S0197-4580(02)00084-2 Bush G, 2000, TRENDS COGN SCI, V4, P215, DOI 10.1016/S1364-6613(00)01483-2 Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099 CHO YH, 1995, NEUROBIOL LEARN MEM, V64, P285 Connor JR, 2011, SLEEP MED, V12, P614, DOI 10.1016/j.sleep.2010.10.009 Conturo TE, 2008, J INT NEUROPSYCH SOC, V14, P933, DOI 10.1017/S1355617708081381 Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005 Cotugno AJ, 2009, J AUTISM DEV DISORD, V39, P1268, DOI 10.1007/s10803-009-0741-4 Courchesne E, 2001, NEUROLOGY, V57, P245 Courchesne E, 2005, INT J DEV NEUROSCI, V23, P153, DOI 10.1016/j.ijdevneu.2005.01.003 Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337 Courchesne E, 2011, BRAIN RES, V1380, P138, DOI 10.1016/j.brainres.2010.09.101 Courchesne E, 2004, MENT RETARD DEV D R, V10, P106, DOI 10.1002/mrdd.20020 Craig MC, 2007, BRIT J PSYCHIAT, V191, P224, DOI 10.1192/bjp.bp.106.034603 DAWSON G, 1987, J AUTISM DEV DISORD, V17, P487, DOI 10.1007/BF01486965 Di Martino A, 2009, BIOL PSYCHIAT, V65, P63, DOI 10.1016/j.biopsych.2008.09.022 Douaud G, 2007, BRAIN, V130, P2375, DOI 10.1093/brain/awm184 Ecker C, 2010, NEUROIMAGE, V49, P44, DOI 10.1016/j.neuroimage.2009.08.024 EGAAS B, 1995, ARCH NEUROL-CHICAGO, V52, P794 Eickhoff SB, 2009, HUM BRAIN MAPP, V30, P2907, DOI 10.1002/hbm.20718 Farr SA, 2000, BRAIN RES, V872, P242, DOI 10.1016/S0006-8993(00)02495-1 Fried I, 2002, CEREB CORTEX, V12, P575, DOI 10.1093/cercor/12.6.575 Fried I, 1997, NEURON, V18, P753, DOI 10.1016/S0896-6273(00)80315-3 Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9 Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037 Gokcen S, 2009, PSYCHIAT RES, V166, P46, DOI 10.1016/j.psychres.2007.11.016 GRABOWSKA A, 1994, ACTA NEUROBIOL EXP, V54, P393 Grant JA, 2010, EMOTION, V10, P43, DOI 10.1037/a0018334 Hadjikhani N, 2004, NEUROIMAGE, V22, P1141, DOI 10.1016/j.neuroimage.2004.03.025 Hardan AY, 2000, NEUROLOGY, V55, P1033 Hardan AY, 2009, BIOL PSYCHIAT, V66, P320, DOI 10.1016/j.biopsych.2009.04.024 Hardan AY, 2001, J CHILD NEUROL, V16, P421, DOI 10.1177/088307380101600607 Hazlett HC, 2011, ARCH GEN PSYCHIAT, V68, P467, DOI 10.1001/archgenpsychiatry.2011.39 Haznedar MM, 2000, AM J PSYCHIAT, V157, P1994, DOI 10.1176/appi.ajp.157.12.1994 Howard MA, 2000, NEUROREPORT, V11, P2931, DOI 10.1097/00001756-200009110-00020 Hyde K., 2009, HUMAN BRAIN MAPPING, V31, P556 Josef Nicolaas van der G., 2001, BIOL PSYCHIAT, V50, P614 Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344 Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Karas GB, 2003, NEUROIMAGE, V18, P895, DOI 10.1016/S1053-8119(03)00041-7 Ke XY, 2009, BRAIN RES, V1265, P171, DOI 10.1016/j.brainres.2009.02.013 Ke XY, 2008, NEUROREPORT, V19, P921, DOI 10.1097/WNR.0b013e328300edf3 Kelly AMC, 2009, CEREB CORTEX, V19, P640, DOI 10.1093/cercor/bhn117 KEMPER TL, 1993, NEUROL CLIN, V11, P175 Klein SB, 2009, SOC COGNITION, V27, P283 Koehl M, 2011, EUR J NEUROSCI, V33, P1101, DOI 10.1111/j.1460-9568.2011.07609.x Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054 Kuusikko S, 2009, J AUTISM DEV DISORD, V39, P938, DOI 10.1007/s10803-009-0700-0 Kwon H, 2004, DEV MED CHILD NEUROL, V46, P760, DOI 10.1017/S0012162204001306 Laird AR, 2005, HUM BRAIN MAPP, V25, P155, DOI 10.1002/hbm.20136 Lancaster JL, 2007, HUM BRAIN MAPP, V28, P1194, DOI 10.1002/hbm.20345 Lecours A. R., 1967, REGIONAL DEV BRAIN E Lemaitre H, 2010, J NEUROSCI, V30, P5992, DOI 10.1523/JNEUROSCI.5773-09.2010 Leung KK, 2010, NEUROIMAGE, V51, P1345, DOI 10.1016/j.neuroimage.2010.03.018 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Machado CJ, 2006, BEHAV NEUROSCI, V120, P761, DOI 10.1037/0735-7044.120.4.761 Manes F, 1999, J NEUROPSYCH CLIN N, V11, P470 McAlonan GM, 2009, PSYCHOL MED, V39, P1885, DOI 10.1017/S0033291709005728 McAlonan GM, 2008, J CHILD PSYCHOL PSYC, V49, P1287, DOI 10.1111/j.1469-7610.2008.01933.x McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150 Mengotti P, 2011, BRAIN RES BULL, V84, P189, DOI 10.1016/j.brainresbull.2010.12.002 Minshew NJ, 2010, CURR OPIN NEUROL, V23, P124, DOI 10.1097/WCO.0b013e32833782d4 Morgado-Bernal I, 2011, NEUROSCIENCE, V176, P12, DOI 10.1016/j.neuroscience.2010.12.056 Ozonoff S, 2004, J AUTISM DEV DISORD, V34, P139, DOI 10.1023/B:JADD.0000022605.81989.cc Piven J, 1997, AM J PSYCHIAT, V154, P1051 Piven J, 1998, J AUTISM DEV DISORD, V28, P105, DOI 10.1023/A:1026084430649 PIVEN J, 1995, AM J PSYCHIAT, V152, P1145 Raymond GV, 1996, ACTA NEUROPATHOL, V91, P117 Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198 RITVO ER, 1986, AM J PSYCHIAT, V143, P862 Riva D, 2011, AM J NEURORADIOL, V32, P1430, DOI 10.3174/ajnr.A2527 Rodier PM, 1996, J COMP NEUROL, V370, P247, DOI 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2 Roid G., 1997, LEITER INT PERFORMAN Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56 Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x SAHLEY TL, 1987, J AUTISM DEV DISORD, V17, P201, DOI 10.1007/BF01495056 SAITOH O, 1995, NEUROLOGY, V45, P317 Salmond CH, 2007, CORTEX, V43, P686, DOI 10.1016/S0010-9452(08)70498-2 Salmond CH, 2005, EUR J NEUROSCI, V22, P764, DOI 10.1111/j.1460-9568.2005.04217.x Schmitz N, 2006, BIOL PSYCHIAT, V59, P7, DOI 10.1016/j.biopsych.2005.06.007 Schmolck H, 2002, HIPPOCAMPUS, V12, P520, DOI 10.1002/hipo.10039 Schumann CM, 2010, J NEUROSCI, V30, P4419, DOI 10.1523/JNEUROSCI.5714-09.2010 Schwarcz R, 2002, EPILEPSY RES, V50, P161, DOI 10.1016/S0920-1211(02)00077-3 Selden NR, 1998, BRAIN, V121, P2249, DOI 10.1093/brain/121.12.2249 Shaw P, 2008, J NEUROSCI, V28, P3586, DOI 10.1523/JNEUROSCI.5309-07.2008 Solomon M, 2008, INT J DEV NEUROSCI, V26, P239, DOI 10.1016/j.ijdevneu.2007.11.001 Sowell ER, 2001, J NEUROSCI, V21, P8819 Sparks BF, 2002, NEUROLOGY, V59, P184 Sparrow S, 1984, VINELAND ADAPTIVE BE Sprenger T, 2006, PAIN, V122, P63, DOI 10.1016/j.pain.2006.01.003 Stanfield AC, 2008, BIOL PSYCHIAT, V63, P80, DOI 10.1016/j.biopsych.2007.04.012 Stigler KA, 2011, BRAIN RES, V1380, P146, DOI 10.1016/j.brainres.2010.11.076 Supekar K, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000157 Talairach J., 1988, COPLANAR STEREOTAXIC Teutsch S, 2008, NEUROIMAGE, V42, P845, DOI 10.1016/j.neuroimage.2008.05.044 Toal F., 2009, PSYCHOL MED, V40, P1171 Tordjman S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005289 Volkmar F, 2005, ANNU REV PSYCHOL, V56, P315, DOI 10.1146/annurev.psych.56.091103.070159 VONCRAMON DY, 1992, CORTEX, V28, P411 Waiter GD, 2004, NEUROIMAGE, V22, P619, DOI 10.1016/j.neuroimage.2004.02.029 Waiter GD, 2005, NEUROIMAGE, V24, P455, DOI 10.1016/j.neuroimage.2004.08.049 Wassink TH, 2007, ARCH GEN PSYCHIAT, V64, P709, DOI 10.1001/archpsyc.64.6.709 Williams DL, 2006, NEUROPSYCHOLOGY, V20, P21, DOI 10.1037/0894-4105.20.1.21 WILLIAMS RS, 1980, ARCH NEUROL-CHICAGO, V37, P749 Wilson LB, 2009, PSYCHIAT RES-NEUROIM, V174, P138, DOI 10.1016/j.pscychresns.2009.04.013 NR 127 TC 25 Z9 26 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2012 VL 5 IS 1 BP 49 EP 66 DI 10.1002/aur.235 PG 18 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 900FG UT WOS:000300871400007 PM 22139976 ER PT J AU de Bildt, A Mulder, EJ Van Lang, NDJ de With, SAJ Minderaa, RB Stahl, SS Anderson, GM AF de Bildt, Annelies Mulder, Erik J. Van Lang, Natasja D. J. de With, S. A. Jytte Minderaa, Ruud B. Stahl, Sherin S. Anderson, George M. TI The visual rooting reflex in individuals with autism spectrum disorders and co-occurring intellectual disability SO AUTISM RESEARCH LA English DT Article DE primitive reflexes; visual rooting reflex; autism; intellectual disability ID PRIMITIVE REFLEXES; SIGNS AB The rooting reflex has long been studied by neurologists and developmentalists and is defined as an orientation toward tactile stimulation in the perioral region or visual stimulation near the face. Nearly, all previous reports of the visual rooting reflex (VRR) concern its presence in adults with neurological dysfunction. Previously, the VRR was reported to be present in a majority of individuals with autism and absent in control subjects. In the present larger study, we examined the presence of the VRR in 155 individuals with ASD and co-occurring Intellectual Disability (ASD + ID: autism, N = 60; Pervasive Developmental Disorder-Not Otherwise Specified (PDD_NOS), N = 95) and in a contrast group of 65 individuals with ID only. The VRR was present significantly more often in the ASD + ID (43.9%) group than in the ID-only group (24.6%; = 7.19; P = 0.007). Individuals with autism displayed a VRR more often (55.0%) than individuals with PDD-NOS (36.8%; = 4.92; P = 0.026) and individuals with ID only (24.6%; = 12.09; P = 0.001). A positive VRR was associated with lower IQ and adaptive functioning; in the ASD + ID group, ADI-R/ADOS domain scores were significantly higher in the VRR-positive subgroup. The results replicate and extend the finding of an increased occurrence of the VRR in autism. Although some association with IQ was observed, the VRR occurred substantially more often in the autism group compared with an intellectually disabled group, indicating some degree of specificity. Additional studies of infants and children with typical development, ASD and ID are needed to determine the utility of the VRR in ASD risk assessment and to elucidate possible specific behavioral associations. Autism Res 2012,5:6772. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [de Bildt, Annelies; Mulder, Erik J.; de With, S. A. Jytte; Minderaa, Ruud B.] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands. [Van Lang, Natasja D. J.] Leiden Univ, Med Ctr, Dept Child & Adolescent Psychiat, Leiden, Netherlands. [Stahl, Sherin S.; Anderson, George M.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA. RP Anderson, GM (reprint author), Yale Child Study Ctr, 230 S Frontage Rd, New Haven, CT 06520 USA. EM george.anderson@yale.edu FU Korczak Foundation for Autism and Related Disorders; Netherlands Organization for Health Research and Development (ZON/MW) FX Children and their parents involved in this study are gratefully acknowledged. Rachel Tobey is thanked for her help in scoring the VRR; Neeltje Valkhof is thanked for her assistance in collecting and organizing the data. The authors gratefully acknowledge the support of the Korczak Foundation for Autism and Related Disorders and the Netherlands Organization for Health Research and Development (ZON/MW). CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Anderson GM, 2008, AUTISM RES, V1, P18, DOI 10.1002/aur.2 Bieber I, 1940, J NERV MENT DIS, V91, P31, DOI 10.1097/00005053-194001000-00003 de Bildt A, 2005, J CHILD PSYCHOL PSYC, V46, P275, DOI 10.1111/j.1469-7610.2004.00346.x FUTAGI Y, 1992, BRAIN DEV-JPN, V14, P294 Go T, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003668 Ingram T. T. S, 1962, DEV MED CHILD NEUROL, V4, P159 JENKYN LR, 1977, J NEUROL NEUROSUR PS, V40, P956, DOI 10.1136/jnnp.40.10.956 Lykken DT, 2006, GENES BRAIN BEHAV, V5, P306, DOI 10.1111/j.1601-183X.2006.00233.x MINDERAA RB, 1985, J AUTISM DEV DISORD, V15, P409, DOI 10.1007/BF01531785 Minshew N. J., 2005, HDB AUTISM PERVASIVE, V1, P453 Rao R, 1999, INT J GERIATR PSYCH, V14, P964, DOI 10.1002/(SICI)1099-1166(199911)14:11<964::AID-GPS51>3.3.CO;2-7 Schott JM, 2003, J NEUROL NEUROSUR PS, V74, P558, DOI 10.1136/jnnp.74.5.558 Turner C., 2006, PRACTICAL NEUROLOGY, V6, P358, DOI 10.1136/jnnp.2006.106443 TWEEDY J, 1982, NEUROLOGY, V32, P169 van Lang NDJ, 2006, J CHILD PSYCHOL PSYC, V47, P37, DOI 10.1111/j.1469-7610.2005.01434.x Zafeiriou DI, 2004, PEDIATR NEUROL, V31, P1, DOI 10.1016/j.pediatrneurol.2004.01.012 NR 17 TC 1 Z9 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2012 VL 5 IS 1 BP 67 EP 72 DI 10.1002/aur.225 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 900FG UT WOS:000300871400008 PM 21954217 ER PT J AU Jacome, LF Burket, JA Herndon, AL Deutsch, SI AF Jacome, Luis F. Burket, Jessica A. Herndon, Amy L. Deutsch, Stephen I. TI Genetically inbred Balb/c mice differ from outbred Swiss Webster mice on discrete measures of sociability: relevance to a genetic mouse model of autism spectrum disorders SO AUTISM RESEARCH LA English DT Article DE Balb; c mouse strain; sociability; autism spectrum disorders ID BEHAVIORAL TASKS RELEVANT; STRAINS DIFFER; MK-801; SCHIZOPHRENIA; SENSITIVITY; PHENOTYPES; ANTAGONIST AB The Balb/c mouse is proposed as a model of human disorders with prominent deficits of sociability, such as autism spectrum disorders (ASDs) that may involve pathophysiological disruption of NMDA receptor-mediated neurotransmission. A standard procedure was used to measure sociability in 8-week-old male genetically inbred Balb/c and outbred Swiss Webster mice. Moreover, because impaired sociability may influence the social behavior of stimulus mice, we also measured the proportion of total episodes of social approach made by the stimulus mouse while test and stimulus mice were allowed to interact freely. Three raters with good inter-rater agreement evaluated operationally defined measures of sociability chosen because of their descriptive similarity to deficits of social behavior reported in persons with ASDs. The data support previous reports that the Balb/c mouse is a genetic mouse model of impaired sociability. The data also show that the behavior of the social stimulus mouse is influenced by the impaired sociability of the Balb/c strain. Interestingly, operationally defined measures of sociability did not necessarily correlate with each other within mouse strain and the profile of correlated measures differed between strains. Finally, stereotypic behaviors (i.e. rearing, grooming and wall climbing) recorded during the session of free interaction between the test and social stimulus mice were more intensely displayed by Swiss Webster than Balb/c mice, suggesting that the domains of sociability and restricted repetitive and stereotyped patterns of behavior are independent of each other in the Balb/c strain. Autism Res 2011,4:393400. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Jacome, Luis F.; Burket, Jessica A.; Herndon, Amy L.; Deutsch, Stephen I.] Eastern Virginia Med Sch, Dept Psychiat & Behav Sci, Norfolk, VA 23507 USA. RP Deutsch, SI (reprint author), Eastern Virginia Med Sch, Dept Psychiat & Behav Sci, 825 Fairfax Ave,Suite 710, Norfolk, VA 23507 USA. EM deutscsi@evms.edu FU Office of the Dean of the Eastern Virginia Medical School FX The authors acknowledge the generous support that they receive from the Office of the Dean of the Eastern Virginia Medical School. CR Billingslea EN, 2003, PHARMACOL BIOCHEM BE, V74, P351, DOI 10.1016/S0091-3057(02)01012-2 Brodkin ES, 2004, BRAIN RES, V1002, P151, DOI 10.1016/j.brainres.2003.12.013 Brodkin ES, 2007, BEHAV BRAIN RES, V176, P53, DOI 10.1016/j.bbr.2006.06.025 Burket JA, 2010, BRAIN RES BULL, V83, P255, DOI 10.1016/j.brainresbull.2010.07.006 Burket JA, 2010, BRAIN RES BULL, V83, P337, DOI 10.1016/j.brainresbull.2010.08.014 Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039 Deutsch SI, 2011, BRAIN RES BULL, V84, P8, DOI 10.1016/j.brainresbull.2010.10.006 Deutsch SI, 1997, PHARMACOL BIOCHEM BE, V57, P315, DOI 10.1016/S0091-3057(96)00347-4 Deutsch SI, 1998, CLIN NEUROPHARMACOL, V21, P255 Halene TB, 2009, GENES BRAIN BEHAV, V8, P661, DOI 10.1111/j.1601-183X.2009.00504.x Jacome LF, 2011, BRAIN RES BULL, V84, P12, DOI 10.1016/j.brainresbull.2010.10.010 McDougle CJ, 2005, AM J PSYCHIAT, V162, P1142, DOI 10.1176/appi.ajp.162.6.1142 Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030 Mugno D, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-22 NORRIS DO, 1994, NEUROCHEM RES, V19, P161, DOI 10.1007/BF00966811 NORRIS DO, 1992, PHARMACOL BIOCHEM BE, V43, P609, DOI 10.1016/0091-3057(92)90198-O Sankoorikal GMV, 2006, BIOL PSYCHIAT, V59, P415, DOI 10.1016/j.biopsych.2005.07.026 Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201 Yang M., 2010, AUTISM RES, V3, P1 NR 20 TC 12 Z9 12 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2011 VL 4 IS 6 BP 393 EP 400 DI 10.1002/aur.218 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 858IK UT WOS:000297789500001 PM 21882363 ER PT J AU Alderson-Day, B AF Alderson-Day, Ben TI Verbal problem-solving in autism spectrum disorders: A problem of plan construction? SO AUTISM RESEARCH LA English DT Article DE autism; problem-solving; executive functioning; planning; categorization ID HIGH-FUNCTIONING AUTISM; DEFICIT HYPERACTIVITY DISORDER; IMPAIRED MEMORY FUNCTIONS; EXECUTIVE FUNCTIONS; ASPERGERS-SYNDROME; CONCEPT-IDENTIFICATION; CLINICAL MEASURE; WORKING-MEMORY; CHILDREN; STRATEGIES AB Children with autism spectrum disorders (ASD) adopt less efficient strategies than typically developing controls (TD) on verbal problem-solving tests such as the Twenty Questions Task. This study examined the hypotheses that this can be explained by differences in (i) planning processes or (ii) selective attention. Twenty-two children with ASD and 21 TD controls matched for age (Mage = 13:7) and cognitive ability (MFSIQ = 96.42) were tested on an adapted version of Twenty Questions and two planning tasks. ASD participants could recognize effective questions as well as TD participants on a forced-choice question discrimination task, but were observed to construct plans that were significantly less efficient. ASD performance was also specifically reduced when items could not be physically removed from the testing array, although this effect could be ameliorated by keeping a written record of participant questions during search. These findings indicate that ASD participants are sensitive to the within-task executive demands of Twenty Questions, but that their inefficiency in strategy relates to planning processes and question selection pretask. The implications for understanding ASD problem-solving skills and their impact on everyday functioning are discussed. Autism Res 2011,4:401-411. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland. RP Alderson-Day, B (reprint author), Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland. EM b.d.alderson-day@sms.ed.ac.uk CR Agran M, 2002, REM SPEC EDUC, V23, P279, DOI 10.1177/07419325020230050301 Alderson-Day B., 2010, J AUTISM DEV DISORD, V41, P555 American Psychiatric Association [APA], 1994, DSM 4 DIAGN STAT MAN Ames CS, 2007, J AUTISM DEV DISORD, V37, P1761, DOI 10.1007/s10803-006-0309-5 Baldo JV, 2004, ARCH CLIN NEUROPSYCH, V19, P407, DOI 10.1016/S0887-6177(03)00074-X BARTON JA, 1988, J EDUC PSYCHOL, V80, P184, DOI 10.1037/0022-0663.80.2.184 Bennetto L, 1996, CHILD DEV, V67, P1816, DOI 10.1111/j.1467-8624.1996.tb01830.x Bishop DVM, 2005, AUTISM, V9, P7, DOI 10.1177/1362361305049027 BORYS SV, 1979, AM J MENT DEF, V84, P280 Bowler DM, 2008, J AUTISM DEV DISORD, V38, P104, DOI 10.1007/s10803-007-0366-4 Bramham J, 2009, AUTISM, V13, P245, DOI 10.1177/1362361309103790 BURACK JA, 1994, J ABNORM PSYCHOL, V103, P535, DOI 10.1037/0021-843X.103.3.535 Christ SE, 2007, J AUTISM DEV DISORD, V37, P1155, DOI 10.1007/s10803-006-0259-y DENNEY DR, 1973, DEV PSYCHOL, V8, P202, DOI 10.1037/h0034144 DENNEY DR, 1972, CHILD DEV, V43, P810, DOI 10.1111/j.1467-8624.1972.tb02036.x DRUMM P, 1995, PERCEPT MOTOR SKILL, V81, P271 Drumm P, 1996, J ADOLESCENT RES, V11, P285, DOI 10.1177/0743554896113002 Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x Glago K, 2009, REM SPEC EDUC, V30, P372, DOI 10.1177/0741932508324394 Glutting J., 2005, WIDE RANGE ACHIEVEME Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4 Joseph RM, 2005, NEUROPSYCHOLOGIA, V43, P1400, DOI 10.1016/j.neuropsychologia.2005.01.010 KLOUDA GV, 1990, PSYCHOL REP, V67, P411, DOI 10.2466/PR0.67.6.411-416 Landa RJ, 2005, J AUTISM DEV DISORD, V35, P557, DOI 10.1007/s10803-005-0001-1 LAUGHLIN PR, 1969, J EDUC PSYCHOL, V60, P188, DOI 10.1037/h0027556 Lopez BR, 2005, J AUTISM DEV DISORD, V35, P445, DOI 10.1007/s10803-005-5035-x LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Marschark M., 1999, DEAFNESS ED INT, V1, P65, DOI 10.1002/dei.48 Marschark M, 2006, EUR J COGN PSYCHOL, V18, P70, DOI 10.1080/09541440500216028 Marschark M, 2004, AM ANN DEAF, V149, P51, DOI 10.1353/aad.2004.0013 Marshall RC, 2008, AM J SPEECH-LANG PAT, V17, P377, DOI 10.1044/1058-0360(2008/07-0071) Marshall RC, 2003, AM J SPEECH-LANG PAT, V12, P333, DOI 10.1044/1058-0360(2003/079) Marshall RC, 2003, BRAIN INJURY, V17, P589, DOI 10.1080/0269905031000088496 MINSHEW NJ, 1994, ARCH CLIN NEUROPSYCH, V9, P31, DOI 10.1016/0887-6177(94)90012-4 Minshew NJ, 2002, NEUROPSYCHOLOGY, V16, P327, DOI 10.1037//0894-4105.16.3.327 Minshew NJ, 2001, J CHILD PSYCHOL PSYC, V42, P1095, DOI 10.1111/1469-7610.00808 Mosher F. A., 1966, STUDIES COGNITIVE GR, P86 O'Hearn K, 2008, DEV PSYCHOPATHOL, V20, P1103, DOI 10.1017/S0954579408000527 OTTEM E, 1980, AM ANN DEAF, V125, P564 Ozonoff S, 2004, J AUTISM DEV DISORD, V34, P139, DOI 10.1023/B:JADD.0000022605.81989.cc Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x Rinehart NJ, 2008, AUTISM, V12, P249, DOI 10.1177/1362361307088754 Ropar D, 2007, J AUTISM DEV DISORD, V37, P270, DOI 10.1007/s10803-006-0166-2 Rutherford MD, 2003, J AUTISM DEV DISORD, V33, P289, DOI 10.1023/A:1024406601334 Scott W. A., 2007, CANADIAN J SCH PSYCH, V22, P249, DOI 10.1177/0829573507308162 SIEGLER RS, 1977, CHILD DEV, V48, P395, DOI 10.1111/j.1467-8624.1977.tb01176.x SIMMONDS EPM, 1990, J LEARN DISABIL, V23, P229 Smith BJ, 2007, J AUTISM DEV DISORD, V37, P445, DOI 10.1007/s10803-006-0180-4 Solomon M, 2011, J AUTISM DEV DISORD, V41, P32, DOI 10.1007/s10803-010-1017-8 Solomon M, 2004, J AUTISM DEV DISORD, V34, P649, DOI 10.1007/s10803-004-5286-y South M, 2007, AUTISM, V11, P437, DOI 10.1177/1362361307079606 TAGERFLUSBERG H, 1985, J EXP CHILD PSYCHOL, V40, P450, DOI 10.1016/0022-0965(85)90077-3 TANT JL, 1982, J ABNORM CHILD PSYCH, V10, P285, DOI 10.1007/BF00912323 UNGERER JA, 1987, J AUTISM DEV DISORD, V17, P3, DOI 10.1007/BF01487256 Upton D, 1999, ARCH CLIN NEUROPSYCH, V14, P203, DOI 10.1016/S0887-6177(98)00013-4 Vaccari C, 1997, J CHILD PSYCHOL PSYC, V38, P793, DOI 10.1111/j.1469-7610.1997.tb01597.x VANHORN KR, 1968, PSYCHON SCI, V11, P341 VASSILOPOULOS CA, 1992, GENET SOC GEN PSYCH, V118, P251 Verte S, 2005, DEV PSYCHOPATHOL, V17, P415, DOI 10.1017/S0954579405050200 Wechsler D, 1999, WECHSLER ABBREVIATED Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd WHO, 1993, ICD 10 CLASS MENT BE Williams DL, 2005, J AUTISM DEV DISORD, V35, P747, DOI 10.1007/s10803-005-0021-x Williams DL, 2006, NEUROPSYCHOLOGY, V20, P21, DOI 10.1037/0894-4105.20.1.21 Yerys BE, 2009, AUTISM RES, V2, P322, DOI 10.1002/aur.103 Yurgelun-Todd D, 2007, CURR OPIN NEUROBIOL, V17, P251, DOI 10.1016/j.conb.2007.03.009 NR 67 TC 2 Z9 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2011 VL 4 IS 6 BP 401 EP 411 DI 10.1002/aur.222 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 858IK UT WOS:000297789500002 PM 21905244 ER PT J AU South, M Larson, MJ White, SE Dana, J Crowley, MJ AF South, Mikle Larson, Michael J. White, Sarah E. Dana, Julianne Crowley, Michael J. TI Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; amygdala; anxiety; fear conditioning; dimensional measures ID NEURAL CIRCUITRY; AMYGDALA THEORY; CHILDREN; STIMULI; EMOTION; IMPAIRMENT; ANXIETY; ABNORMALITIES; RESPONSES; DEFICITS AB Evidence from behavioral and neuroimaging studies suggest that atypical amygdala function plays a critical role in the development of autism spectrum disorders (ASD). The handful of psychophysiological studies examining amygdala function in ASD using classical fear conditioning paradigms have yielded discordant results. We recorded skin conductance response (SCR) during a simple discrimination conditioning task in 30 children and adolescents (ages 818) diagnosed with high-functioning ASD and 30 age- and IQ-matched, typically developing controls. SCR response in the ASD group was uniquely and positively associated with social anxiety; and negatively correlated with autism symptom severity, in particular with social functioning. Fear conditioning studies have tremendous potential to aid understanding regarding the amygdale's role in the varied symptom profile of ASD. Our data demonstrate that such studies require careful attention to task-specific factors, including task complexity; and also to contributions of dimensional, within-group factors that contribute to ASD heterogeneity. Autism Res 2011,4:412-421. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [South, Mikle; Larson, Michael J.; Dana, Julianne] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA. [South, Mikle; Larson, Michael J.; White, Sarah E.] Brigham Young Univ, Ctr Neurosci, Provo, UT 84602 USA. [Crowley, Michael J.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA. RP South, M (reprint author), Brigham Young Univ, Dept Psychol, 245 TLRB,1190 North,900 East, Provo, UT 84602 USA. EM south@byu.edu RI Larson, Michael/C-8543-2012; South, Mikle/H-4978-2013 OI South, Mikle/0000-0003-0152-1257 FU Brigham Young University; Family Studies Center; College of Home, Family, and Social Sciences FX Grant sponsor: Brigham Young University, Mentored Environment GrantThank you to all the children and families who volunteered to participate in this study. We gratefully acknowledge the able assistance of Annahir Cariello, Oliver Johnston, Jaime Ballard, Adrian Rockwell, Ryan Hunsaker, Sarah Van Tassell, Kyle Jamison, and Tiffani Newton. This work was supported by research grants from Brigham Young University, including the Family Studies Center; the College of Home, Family, and Social Sciences; and a Mentored Environment Grant. CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005 Amaral DG, 2003, NOVART FDN SYMP, V251, P177 (APA) APA, 2000, DIAGN STAT MAN MENT Baron-Cohen S, 2000, NEUROSCI BIOBEHAV R, V24, P355, DOI 10.1016/S0149-7634(00)00011-7 Ben Shalom D, 2006, J AUTISM DEV DISORD, V36, P395, DOI 10.1007/s10803-006-0077-2 Bernier R, 2005, J AUTISM DEV DISORD, V35, P575, DOI 10.1007/s10803-005-0002-0 Bill BR, 2009, CURR OPIN GENET DEV, V19, P271, DOI 10.1016/j.gde.2009.04.004 Birmaher B, 1999, J AM ACAD CHILD PSY, V38, P1230, DOI 10.1097/00004583-199910000-00011 Corbett BA, 2009, PSYCHIAT RES-NEUROIM, V173, P196, DOI 10.1016/j.pscychresns.2008.08.005 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Davis M, 2001, MOL PSYCHIATR, V6, P13, DOI 10.1038/sj.mp.4000812 Dziobek I, 2010, ARCH GEN PSYCHIAT, V67, P397, DOI 10.1001/archgenpsychiatry.2010.31 Gaigg SB, 2009, J AUTISM DEV DISORD, V39, P1031, DOI 10.1007/s10803-009-0710-y Gaigg SB, 2007, NEUROPSYCHOLOGIA, V45, P2125, DOI 10.1016/j.neuropsychologia.2007.01.012 Gaigg SB, 2009, J AUTISM DEV DISORD, V39, P1211, DOI 10.1007/s10803-009-0719-2 Hubert BE, 2009, AUTISM, V13, P9, DOI 10.1177/1362361308091649 JARRELL TW, 1987, BRAIN RES, V412, P285, DOI 10.1016/0006-8993(87)91135-8 Joseph RM, 2008, J INT NEUROPSYCH SOC, V14, P947, DOI 10.1017/S1355617708081344 Kanner L, 1943, NERV CHILD, V2, P217 Kent Justine M, 2003, Curr Psychiatry Rep, V5, P266, DOI 10.1007/s11920-003-0055-8 Kleinhans NM, 2011, NEUROIMAGE, V54, P697, DOI 10.1016/j.neuroimage.2010.07.037 Klin A, 2005, J AUTISM DEV DISORD, V35, P221, DOI 10.1007/s10803-005-2001-6 LABAR KS, 1995, J NEUROSCI, V15, P6846 Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lord C, 2009, BRIT J HOSP MED, V70, P132 Maras K, 2011, J AUTISM DEV DISORD, V41, P815, DOI 10.1007/s10803-010-1089-5 Marsh A.A., 2010, NEURAL SUBSTRATES AC Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945 Monk CS, 2010, J PSYCHIATR NEUROSCI, V35, P105, DOI 10.1503/jpn.090085 Morris JS, 1997, P ROY SOC B-BIOL SCI, V264, P769 Mosconi MW, 2009, ARCH GEN PSYCHIAT, V66, P509, DOI 10.1001/archgenpsychiatry.2009.19 Munson J, 2006, ARCH GEN PSYCHIAT, V63, P686, DOI 10.1001/archpsyc.63.6.686 Noriuchi M, 2010, BRAIN RES, V1362, P141, DOI 10.1016/j.brainres.2010.09.051 Ohman A, 2009, SCAND J PSYCHOL, V50, P543, DOI 10.1111/j.1467-9450.2009.00784.x Pelphrey KA, 2008, DEV PSYCHOPATHOL, V20, P1081, DOI 10.1017/S0954579408000515 Rau V, 2009, STRESS, V12, P125, DOI 10.1080/10253890802137320 Roozendaal B, 2009, NAT REV NEUROSCI, V10, P423, DOI 10.1038/nrn2651 Salmond CH, 2003, PHILOS T ROY SOC B, V358, P405, DOI 10.1098/rstb.2002.1210 Sasson N, 2007, NEUROPSYCHOLOGIA, V45, P2580, DOI 10.1016/j.neuropsychologia.2007.03.009 Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004 Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007 Sotres-Bayon F, 2004, LEARN MEMORY, V11, P525, DOI 10.1101/lm.79504 South M., 2011, NEUROPSYCHOLOGY AUTI, P225 South M, 2008, J INT NEUROPSYCH SOC, V14, P42, DOI 10.1017/S1355617708080107 South M., 2010, J AUTISM DEV DISORDE Tabachnick B.G., 1996, USING MULTIVARIATE S, V2nd Tottenham N, 2009, PSYCHIAT RES, V168, P242, DOI 10.1016/j.psychres.2008.05.006 Truitt WA, 2007, PSYCHOPHARMACOLOGY, V191, P107, DOI 10.1007/s00213-006-0674-y Weng SJ, 2010, BRAIN RES, V1313, P202, DOI 10.1016/j.brainres.2009.11.057 White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003 Wilbarger JL, 2009, NEUROPSYCHOLOGIA, V47, P1323, DOI 10.1016/j.neuropsychologia.2009.01.025 NR 53 TC 12 Z9 12 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2011 VL 4 IS 6 BP 412 EP 421 DI 10.1002/aur.221 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 858IK UT WOS:000297789500003 PM 21905243 ER PT J AU Naigles, LR Kelty, E Jaffery, R Fein, D AF Naigles, Letitia R. Kelty, Emma Jaffery, Rose Fein, Deborah TI Abstractness and continuity in the syntactic development of young children with autism SO AUTISM RESEARCH LA English DT Article DE developmental psychology; preschoolers < pediatrics; language; grammar ID SENTENCE COMPREHENSION; LANGUAGE-ACQUISITION; SPECTRUM DISORDERS; ADAPTIVE-BEHAVIOR; WORD-ORDER; INDIVIDUALS; TODDLERS; INFANTS; CATEGORIZATION; IMPAIRMENT AB Grammar is frequently considered to be a strength in the cognitive profile of individuals with autism spectrum disorders (ASDs); however, few studies have investigated how abstract (i.e. distinct from specific lexical items) is the grammatical knowledge of individuals with ASD. In this study, we examine the extent to which children with ASD have abstracted the transitive (SVO) frame in English. Participants in a longitudinal study of language acquisition in children with autism (17 children with ASD averaging 41 months of age, 18 TD children averaging 28 months of age) were taught two novel verbs in transitive sentences and asked (via intermodal preferential looking) whether these verbs mapped onto novel causative vs. noncausative actions. Both groups consistently mapped the verbs onto the causative actions (i.e. they engaged in syntactic bootstrapping). Moreover, the children with ASD's performance on this task was significantly and independently predicted by both vocabulary and sentence-processing measures obtained 8 months earlier. We conclude that many children with ASD are able to generalize grammatical patterns, and this ability may derive from earlier lexical and grammatical knowledge. Autism Res 2011,4:422-437. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Naigles, Letitia R.] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA. RP Naigles, LR (reprint author), Univ Connecticut, Dept Psychol, 406 Babbidge Rd,Unit 1020, Storrs, CT 06269 USA. EM letitia.naigles@uconn.edu FU National Institutes of Health [R01 DC07428, R01 2DC007428] FX Grant sponsor: National Institutes of Health; Grant numbers: R01 DC07428; R01 2DC007428. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT BaronCohen S, 1997, CHILD DEV, V68, P48 Bates E, 1998, EMERGENCE LANGUAGE, P29 Bavin E., 2000, P 5 ANN AUSTT COGN S Bebko JM, 2006, J CHILD PSYCHOL PSYC, V47, P88, DOI 10.1111/j.1469-7610.2005.01443.x Brock J, 2008, COGNITION, V108, P896, DOI 10.1016/j.cognition.2008.06.007 Charman T, 2003, INT J LANG COMM DIS, V38, P265, DOI 10.1080/136820310000104830 Chlebowski C., 2010, J AUTISM DEV DISORDE Chomsky N., 1965, ASPECTS THEORY SYNTA Clark EV, 2009, 1 LANGUAGE ACQUISITI, V2nd Cohen J., 1988, STAT POWER ANAL BEHA, V2nd Courchesne R., 1994, ATYPICAL COGNITIVE D, P101 Echols C. H., 2004, WEAVING LEXICON, P41 Eigsti IM, 2007, J AUTISM DEV DISORD, V37, P1007, DOI 10.1007/s10803-006-0239-2 Fein D., 1996, PRESCHOOL CHILDREN I, P123 Fenson L., 1994, MONOGRAPHS SOC RES C, V59 Fernald A, 2006, DEV PSYCHOL, V42, P98, DOI 10.1037/0012-1649.42.1.98 Fisher C, 1996, CHILD DEV, V67, P3192, DOI 10.1111/j.1467-8624.1996.tb01909.x Fisher C., 2002, DEVELOPMENTAL SCI, V5, P56 Franken T., 2009, J AUTISM DEV DISORD, V40, P255 Gabriels RL, 2001, AUTISM, V5, P407, DOI 10.1177/1362361301005004006 Gerken L., 2007, BLACKWELL HDB LANGUA, P173, DOI 10.1002/9780470757833.ch9 Gertner Y, 2006, PSYCHOL SCI, V17, P684, DOI 10.1111/j.1467-9280.2006.01767.x Gervain J, 2008, COGNITIVE PSYCHOL, V57, P56, DOI 10.1016/j.cogpsych.2007.12.001 Gleitman L., 1990, LANG ACQUIS, V1, P1, DOI [10.1207/s15327817la0101_2, DOI 10.1207/S153278171A0101_2, 10.1207/s153278171a0101_2] Gleitman L. R., 2005, LANGUAGE LEARNING DE, V1, P23, DOI [10.1207/s15473341lld0101_4, DOI 10.1207/S1547334111D0101_4] Hirsh-Pasek K., 1996, ORIGINS GRAMMAR EVID Hohle B, 2009, CAMB HB LANG LINGUIS, P125 Jones W., 2008, AUTISM INTEGRATED VI, P62 Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287 Kuhl P., 2005, LANGUAGE LEARNING DE, V1, P237, DOI DOI 10.1080/15475441.2005.9671948 Landry R, 2004, J CHILD PSYCHOL PSYC, V45, P1115, DOI 10.1111/j.1469-7610.2004.00304.x Lopez B., 2008, AUTISM INTEGRATED VI, P104 Lord C., 1989, AUTISM DIAGNOSTIC OB LOVELAND KA, 1991, AM J MENT RETARD, V96, P13 McDaniel D., 1998, METHODS ASSESSING CH Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303 Minshew NJ, 2002, NEUROPSYCHOLOGY, V16, P327, DOI 10.1037//0894-4105.16.3.327 Mullen E., 1994, MULLEN SCALES INFANT Naigles L., 1998, ADV INFANCY RES, V12, P298 Naigles L. R., 2009, MONOGRAPHS SOC RES C, V74 Naigles L. R., 2007, HDB LANGUAGE DEV, P212 NAIGLES L, 1990, J CHILD LANG, V17, P357 NAIGLES LG, 1993, CHILD DEV, V64, P1665, DOI 10.1111/j.1467-8624.1993.tb04206.x Naigles LR, 2002, COGNITION, V86, P157, DOI 10.1016/S0010-0277(02)00177-4 NAIGLES LR, 1995, DEV PSYCHOL, V31, P827, DOI 10.1037//0012-1649.31.5.827 Naigles LR, 2005, DEVELOPMENTAL SCI, V8, P424, DOI 10.1111/j.1467-7687.2005.00431.x Newell L.C., 2007, INTERSENSORY PERCEPT Newman R, 2006, DEV PSYCHOL, V42, P643, DOI 10.1037/0012-1649.42.4.643 Parish-Morris J, 2007, CHILD DEV, V78, P1265, DOI 10.1111/j.1467-8624.2007.01065.x PAUL R, 1988, J AUTISM DEV DISORD, V18, P669, DOI 10.1007/BF02211884 Paul R, 2008, AUTISM RES, V1, P97, DOI 10.1002/aur.12 Paul R., 2007, LANGUAGE DISORDERS D, P163 Pine JM, 1998, LINGUISTICS, V36, P807, DOI 10.1515/ling.1998.36.4.807 Preissler MA, 2005, COGNITION, V97, pB13, DOI 10.1016/j.cognition.2005.01.008 Radford A., 1990, LANG ACQUIS, V1, P195, DOI 10.1207/s15327817la0103_1 Rapin I, 2003, BRAIN DEV-JPN, V25, P166, DOI 10.1016/S0387-7604(02)00191-2 Roberts JA, 2004, APPL PSYCHOLINGUIST, V25, P429, DOI 10.1017/S0142716404001201 Schopler E., 1988, CHILDHOOD AUTISM RAT SHULMAN C, 1995, J ABNORM PSYCHOL, V104, P601, DOI 10.1037//0021-843X.104.4.601 Shulman C, 2007, J CHILD LANG, V34, P411, DOI 10.1017/S0305000906007963 Sparrow S, 1984, VINELAND ADAPTIVE BE Swensen L. D., 2007, BUCLD 31, P609 Swensen L.D., 2008, INT M AUT RES LOND E Swensen LD, 2007, CHILD DEV, V78, P542, DOI 10.1111/j.1467-8624.2007.01022.x TAGERFLUSBERG H, 1990, J AUTISM DEV DISORD, V20, P1, DOI 10.1007/BF02206853 Tager-Flusberg H, 2001, INT REV RES MENT RET, V23, P185 Tager-Flusberg H, 2003, PHILOS T ROY SOC B, V358, P303, DOI 10.1098/rstb.2002.1198 TAGERFLUSBERG H, 1985, J EXP CHILD PSYCHOL, V40, P450, DOI 10.1016/0022-0965(85)90077-3 TAGERFLUSBERG H, 1994, CONSTRAINTS LANGUAGE Takarae Y, 2008, J INT NEUROPSYCH SOC, V14, P980, DOI 10.1017/S1355617708081277 Tek S., 2008, AUTISM RES, V1, P202 Tomasello M, 2000, COGNITION, V74, P209, DOI 10.1016/S0010-0277(99)00069-4 Tomasello M., 1992, 1 VERBS CASE STUDY E Tomasello Michael, 2003, CONSTRUCTING LANGUAG Travers B., 2010, NEUROPSYCHO IN PRESS Valian V, 2009, J CHILD LANG, V36, P743, DOI 10.1017/S0305000908009082 VanMeter L, 1997, J AUTISM DEV DISORD, V27, P557, DOI 10.1023/A:1025830110640 Ventola PE, 2006, J AUTISM DEV DISORD, V36, P839, DOI 10.1007/s10803-006-0128-8 VOLKMAR FR, 1987, J AM ACAD CHILD PSY, V26, P156, DOI 10.1097/00004583-198703000-00005 Walenski M., 2006, UNDERSTANDING AUTISM, P174 WATERHOUSE L, 1982, BRAIN LANG, V15, P307, DOI 10.1016/0093-934X(82)90062-1 Waxman SR, 2009, COGNITIVE PSYCHOL, V59, P67, DOI 10.1016/j.cogpsych.2009.02.001 NR 83 TC 13 Z9 13 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2011 VL 4 IS 6 BP 422 EP 437 DI 10.1002/aur.223 PG 16 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 858IK UT WOS:000297789500004 PM 22012625 ER PT J AU Pinborough-Zimmerman, J Bilder, D Bakian, A Satterfield, R Carbone, PS Nangle, BE Randall, H McMahon, WM AF Pinborough-Zimmerman, Judith Bilder, Deborah Bakian, Amanda Satterfield, Robert Carbone, Paul S. Nangle, Barry E. Randall, Harper McMahon, William M. TI Sociodemographic risk factors associated with autism spectrum disorders and intellectual disability SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; intellectual disability; sociodemographic; socioeconomic ID PERVASIVE DEVELOPMENTAL DISORDERS; US METROPOLITAN-AREA; MENTAL-RETARDATION; DOWN-SYNDROME; EPIDEMIOLOGIC SURVEY; WESTERN-AUSTRALIA; INFANTILE-AUTISM; SEX-DIFFERENCES; UNITED-STATES; MATERNAL AGE AB This study examined the hypotheses that (1) sociodemographic risk factors in young children with autism spectrum disorders (ASD) and/or intellectual disability (ID) significantly vary by disability type, and (2) measures of income (mean adjusted gross income, mean federal taxes paid, and mean tax exemptions) significantly increase between 1994 and 2002, and are lower in families with a child with ASD and/or ID compared with the general population. A multiple source surveillance system utilizing a retrospective record review was used to identify ASD and ID cases from a population of 26,108 eight-year-old children born in 1994 and living in Utah in 2002. ASD without ID (ASD-only, n = 99) cases were significantly more likely to be male (P<0.01) and have mothers of White non-Hispanic ethnicity (P = 0.02). ASD with ID (ASD/ID, n = 33) cases were significantly more likely to be male (P<0.01) and have mothers older than 34 years (P = 0.03). ID without ASD (ID-only, n = 113) cases were significantly more likely to have fathers older than 34 years (P<0.01) and were significantly less likely to have mothers with >13 years education (P<0.01). Measures of income for cases at birth and at 8 years of age were not significantly lower than the general population and mean adjusted income of cases significantly increased from birth to 8 years of age. Investigations focused on defining early sociodemographic risk factors by different endophenotypes of ASD may assist in identifying risk factors for this complex group of neurodevelopmental disorders. Aggregate tax information may be a unique resource to utilize for population-based analysis. Autism Res 2011,4:438448. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Pinborough-Zimmerman, Judith; Bilder, Deborah; Bakian, Amanda; McMahon, William M.] Univ Utah, Dept Psychiat, Salt Lake City, UT 84108 USA. [Satterfield, Robert; Nangle, Barry E.; Randall, Harper] Utah Dept Hlth, Salt Lake City, UT 84116 USA. [Carbone, Paul S.] Univ Utah, Dept Pediat, Salt Lake City, UT 84108 USA. RP Pinborough-Zimmerman, J (reprint author), Univ Utah, Dept Psychiat, 650 Komas Dr,Suite 206, Salt Lake City, UT 84108 USA. EM judith.zimmerman@hsc.utah.edu FU Centers for Disease Control and Prevention [CCU822365] FX Grant sponsor: Centers for Disease Control and Prevention; Grant number: CCU822365. CR Accardo PJ, 1998, MENT RETARD DEV D R, V4, P2, DOI 10.1002/(SICI)1098-2779(1998)4:1<2::AID-MRDD2>3.0.CO;2-T American Psychiatric Association, 2000, DIAGN STAT MAN MENT [Anonymous], 1997, INT STAT CLASS DIS R Arvidsson B., 1997, AUTISM, V1, P163 Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Baird T.D., 1985, AM J MENT DEFIC, V89, P323 Barbaresi WJ, 2005, ARCH PEDIAT ADOL MED, V159, P37, DOI 10.1001/archpedi.159.1.37 Baron-Cohen S., 2003, ESSENTIAL DIFFERENCE Betrand J., 2001, PEDIATRICS, V108, P1155 Bhasin TK, 2007, J AUTISM DEV DISORD, V37, P667, DOI 10.1007/s10803-006-0194-y Bhasin TK, 2006, MMWR-MORBID MORTAL W, V55, P105 Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927 BRYSON SE, 1988, J CHILD PSYCHOL PSYC, V29, P433, DOI 10.1111/j.1469-7610.1988.tb00735.x Bryson SE, 2008, CAN J PSYCHIAT, V53, P449 CDC (Cent. Dis. Control Prev.), 2009, MMWR-MORBID MORTAL W, V58, P1 CDC (Cent. Dis. Control Prev.), 2007, MMWR SURVEILL SUMM, V56, P12 Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093 Chapman DA, 2002, AM J MENT RETARD, V107, P46, DOI 10.1352/0895-8017(2002)107<0046:ERFFMR>2.0.CO;2 Cocchi G, 2010, BIRTH DEFECTS RES A, V88, P474, DOI 10.1002/bdra.20666 Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950 Croen LA, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.6.e86 de Bildt A, 2004, J AUTISM DEV DISORD, V34, P129 Decoufle Pierre, 1995, Annals of Epidemiology, V5, P347, DOI 10.1016/1047-2797(95)00031-2 De Souza E, 2009, AM J MED GENET A, V149A, P1205, DOI 10.1002/ajmg.a.32850 DREWS CD, 1995, AM J PUBLIC HEALTH, V85, P329, DOI 10.2105/AJPH.85.3.329 DRILLIEN CM, 1966, ARCH DIS CHILD, V41, P528 Durkin M. S., 2010, PLOS ONE, V5, P1 Durkin MS, 2008, AM J EPIDEMIOL, V168, P1268, DOI 10.1093/aje/kwn250 Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3 Fombonne E., 2006, UNDERSTANDING AUTISM, P25 Fombonne E, 1997, J AM ACAD CHILD PSY, V36, P1561, DOI 10.1016/S0890-8567(09)66566-7 Fombonne E, 2001, PEDIATRICS, V107, P411, DOI 10.1542/peds.107.2.411 Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618 Heikura U, 2008, AM J EPIDEMIOL, V167, P169, DOI 10.1093/aje/kwm291 Herman AA, 1997, PAEDIATR PERINAT EP, V11, P5, DOI 10.1046/j.1365-3016.11.s1.11.x Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15 Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6 King M., 2009, INT J EPIDEMIOL 0907 Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522 La Malfa G, 2004, J INTELL DISABIL RES, V48, P262, DOI 10.1111/j.1365-2788.2003.00567.x Larsson H.J., 2005, AM J EPIDEMIOL, V161, P915 Leonard H, 2002, MENT RETARD DEV D R, V8, P117, DOI 10.1002/mrdd.10031 Leonard H, 2005, SOC SCI MED, V60, P1499, DOI 10.1016/j.socscimed.2004.08.014 Lunsky Y, 2009, AJIDD-AM J INTELLECT, V114, P52, DOI 10.1352/2009.114:52-60 Maenner M.J., 2009, SOCIOECONOMIC DISPAR, V108, P253 Maimburg RD, 2006, ACTA PSYCHIAT SCAND, V114, P257, DOI 10.1111/j.1600-0447.2006.00805.x Mandell DS, 2009, AM J PUBLIC HEALTH, V99, P493, DOI 10.2105/AJPH.2007.131243 MCLAREN J, 1987, AM J MENT RETARD, V92, P243 Montes G, 2008, PEDIATRICS, V121, pE821, DOI 10.1542/peds.2007-1594 MUNRO JD, 1986, PSYCHIAT CLIN N AM, V9, P591 MURPHY CC, 1995, AM J PUBLIC HEALTH, V85, P319, DOI 10.2105/AJPH.85.3.319 Nassar N, 2009, INT J EPIDEMIOL, V38, P1245, DOI 10.1093/ije/dyp260 Pinborough-Zimmerman J., 2010, HEALTH, V14, P392 Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026 RICHARDSON SA, 1986, AM J MENT RETARD, V91, P250 RITVO ER, 1989, AM J PSYCHIAT, V146, P194 Schieve LA, 2007, PEDIATRICS, V119, pS114, DOI 10.1542/peds.2006-2089Q SHAH A, 1982, APPL RES MENT RETARD, V3, P303, DOI 10.1016/0270-3092(82)90022-4 Shattuck P.T., 2006, PEDIATRICS, V117, P1436 Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116 Shin M, 2009, PEDIATRICS, V124, P1565, DOI 10.1542/peds.2009-0745 Skuse DH, 2000, PEDIATR RES, V47, P9, DOI 10.1203/00006450-200001000-00006 STEFFENBURG S, 1986, BRIT J PSYCHIAT, V149, P81, DOI 10.1192/bjp.149.1.81 U.S. Census Bureau, MED HOUS INC STAT U.S. Census Bureau, 1980, NUMB POOR POV RAT ST Van Naarden Braun Kim, 2007, MMWR Surveill Summ, V56, P29 Van Meter KC, 2010, AUTISM RES, V3, P19, DOI 10.1002/aur.110 Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49 NR 68 TC 9 Z9 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2011 VL 4 IS 6 BP 438 EP 448 DI 10.1002/aur.224 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 858IK UT WOS:000297789500005 PM 21905245 ER PT J AU Hedley, D Brewer, N Young, R AF Hedley, Darren Brewer, Neil Young, Robyn TI Face recognition performance of individuals with Asperger syndrome on the Cambridge face memory test SO AUTISM RESEARCH LA English DT Article DE face recognition; autism spectrum disorder; Asperger syndrome; CFMT; face perception ID CAST CHILDHOOD ASPERGER; DEVELOPMENTAL PROSOPAGNOSIA; AUTISM; CHILDREN; PERCEPTION; ABILITY; IMPAIRMENT; DISORDERS; ACCURACY; BATTERY AB Although face recognition deficits in individuals with Autism Spectrum Disorder (ASD), including Asperger syndrome (AS), are widely acknowledged, the empirical evidence is mixed. This in part reflects the failure to use standardized and psychometrically sound tests. We contrasted standardized face recognition scores on the Cambridge Face Memory Test (CFMT) for 34 individuals with AS with those for 42, IQ-matched non-ASD individuals, and age-standardized scores from a large Australian cohort. We also examined the influence of IQ, autistic traits, and negative affect on face recognition performance. Overall, participants with AS performed significantly worse on the CFMT than the non-ASD participants and when evaluated against standardized test norms. However, while 24% of participants with AS presented with severe face recognition impairment (>2 SDs below the mean), many individuals performed at or above the typical level for their age: 53% scored within +/- 1 SD of the mean and 9% demonstrated superior performance (>1 SD above the mean). Regression analysis provided no evidence that IQ, autistic traits, or negative affect significantly influenced face recognition: diagnostic group membership was the only significant predictor of face recognition performance. In sum, face recognition performance in ASD is on a continuum, but with average levels significantly below non-ASD levels of performance. Autism Res 2011,4:449-455. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Hedley, Darren; Brewer, Neil; Young, Robyn] Flinders Univ S Australia, Sch Psychol, Adelaide, SA 5001, Australia. RP Brewer, N (reprint author), Flinders Univ S Australia, Sch Psychol, GPO Box 2100, Adelaide, SA 5001, Australia. EM Neil.Brewer@flinders.edu.au FU Flinders University; Australian Research Council (ARC) [LE0882562, DP1093210] FX Grant sponsors: Flinders University Research Grant; Australian Research Council (ARC); Grant numbers: LE0882562; DP1093210. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Annaz D, 2009, J EXP CHILD PSYCHOL, V102, P456, DOI 10.1016/j.jecp.2008.11.005 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Baron-Cohen S, 2006, J AUTISM DEV DISORD, V36, P343, DOI 10.1007/s10803-006-0073-6 Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY Benton A., 1994, BENTON FACIAL RECOGN Blair RJR, 2002, NEUROPSYCHOLOGIA, V40, P108, DOI 10.1016/S0028-3932(01)00069-0 BOUCHER J, 1992, J CHILD PSYCHOL PSYC, V33, P843, DOI 10.1111/j.1469-7610.1992.tb01960.x Bowles DC, 2009, COGN NEUROPSYCHOL, V26, P423, DOI 10.1080/02643290903343149 Campbell R, 2006, DEV PSYCHOPATHOL, V18, P99, DOI 10.1017/S0954579406060068 Crookes K, 2009, COGNITION, V111, P219, DOI 10.1016/j.cognition.2009.02.004 DAVIES S, 1994, J CHILD PSYCHOL PSYC, V35, P1033, DOI 10.1111/j.1469-7610.1994.tb01808.x Drakeford JL, 2007, J NEUROL NEUROSUR PS, V78, P782 Duchaine B, 2006, NEUROPSYCHOLOGIA, V44, P576, DOI 10.1016/j.neuropsychologia.2005.07.001 Duchaine BC, 2003, NEUROPSYCHOLOGIA, V41, P713, DOI 10.1016/S0028-3932(02)00222-1 ELLIS HD, 1994, EUR CHILD ADOLES PSY, V3, P255 Germine LT, 2011, COGNITION, V118, P201, DOI 10.1016/j.cognition.2010.11.002 Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279 GILLBERG IC, 1989, J CHILD PSYCHOL PSYC, V30, P631, DOI 10.1111/j.1469-7610.1989.tb00275.x Hauck M, 1998, CHILD NEUROPSYCHOL, V4, P187, DOI 10.1076/chin.4.3.187.3174 Herlitz A, 2002, J CLIN EXP NEUROPSYC, V24, P107, DOI 10.1076/jcen.24.1.107.970 Herzmann G, 2008, BEHAV RES METHODS, V40, P840, DOI 10.3758/BRM.40.3.840 HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441 Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240 LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lovibond SH, 1995, MANUAL DEPRESSION AN Minshew N.J., 2009, INT M AUT RES CHIC O'Hearn K, 2010, NEUROPSYCHOLOGIA, V48, P3955, DOI 10.1016/j.neuropsychologia.2010.08.024 Richler JJ, 2011, PSYCHOL SCI, V22, P464, DOI 10.1177/0956797611401753 Russell R, 2009, PSYCHON B REV, V16, P252, DOI 10.3758/PBR.16.2.252 Scott FJ, 2002, AUTISM, V6, P9, DOI 10.1177/1362361302006001003 Trepagnier C, 2002, CYBERPSYCHOL BEHAV, V5, P213, DOI 10.1089/109493102760147204 VOLKMAR FR, 1989, J CHILD PSYCHOL PSYC, V30, P591, DOI 10.1111/j.1469-7610.1989.tb00270.x Warrington E., 1984, RECOGNITION MEMORY T Wechsler D, 1999, WECHSLER ABBREVIATED White S, 2006, BRAIN COGNITION, V61, P69, DOI 10.1016/j.bande.2005.12.007 Williams DL, 2005, ARCH CLIN NEUROPSYCH, V20, P1, DOI 10.1016/j.acn.2002.08.001 Williams J, 2005, AUTISM, V9, P45, DOI 10.1177/136261305049029 Wilmer JB, 2010, P NATL ACAD SCI USA, V107, P5238, DOI 10.1073/pnas.0913053107 Wilson CE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012876 Wilson CE, 2010, COGN NEUROPSYCHOL, V27, P30, DOI 10.1080/02643294.2010.490207 Wilson RR, 2009, INFANT CHILD DEV, V18, P545, DOI 10.1002/icd.638 Wolf JM, 2008, AUTISM RES, V1, P329, DOI 10.1002/aur.56 Yardley L, 2008, J PSYCHOSOM RES, V65, P445, DOI 10.1016/j.jpsychores.2008.03.013 Zhu Q, 2010, CURR BIOL, V20, P137, DOI 10.1016/j.cub.2009.11.067 NR 46 TC 12 Z9 12 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2011 VL 4 IS 6 BP 449 EP 455 DI 10.1002/aur.214 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 858IK UT WOS:000297789500006 PM 22162360 ER PT J AU Hoshiko, S Grether, JK Windham, GC Smith, D Fessel, K AF Hoshiko, Sumi Grether, Judith K. Windham, Gayle C. Smith, Daniel Fessel, Karen TI Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis? SO AUTISM RESEARCH LA English DT Article DE epidemiology; autism; thyroid; environment; hormones ID SPECTRUM DISORDERS; STIMULATING HORMONE; COGNITIVE FUNCTION; PREGNANCY; HYPOTHYROIDISM; DISRUPTION; CALIFORNIA; THYROXINE; CHILDREN AB Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.305.75; 1994: OR = 1.71 (95% CI 0.575.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. Autism Res 2011,4:456463. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Hoshiko, Sumi; Grether, Judith K.; Windham, Gayle C.; Smith, Daniel; Fessel, Karen] Calif Dept Publ Hlth, Environm Hlth Invest Branch, Richmond, CA 94804 USA. RP Hoshiko, S (reprint author), Calif Dept Publ Hlth, Environm Hlth Invest Branch, 850 Marina Bay Pkwy,Bldg P,3rd Floor, Richmond, CA 94804 USA. EM sumi.hoshiko@cdph.ca.gov FU California Department of Public Health; National Center for Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention [CDC U10/CCU920392] FX Grant sponsor: California Department of Public Health.The authors thank Meredith Anderson for data management support and Fred Lorey, PhD, and Martin Kharazzi, PhD, for assistance with and interpretation of thyroid data from the Genetic Disease Screening Program. This work was supported by the California Department of Public Health; and, in part, by a Cooperative Agreement with the National Center for Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention [CDC U10/CCU920392]. CR Altman DG, 2003, BRIT MED J, V326, P219, DOI 10.1136/bmj.326.7382.219 Alvarez-Pedrerol M, 2007, CLIN ENDOCRINOL, V66, P890, DOI 10.1111/j.1365-2265.2007.02871.x Armitage P, 2002, STAT METHODS MED RES Blount BC, 2006, ENVIRON HEALTH PERSP, V114, P1865, DOI 10.1289/ehp.9466 Builee TL, 2004, DRUG CHEM TOXICOL, V27, P405, DOI 10.1081/DCT-200039780 COHEN DJ, 1980, J AUTISM DEV DISORD, V10, P445, DOI 10.1007/BF02414820 Colborn T, 2004, ENVIRON HEALTH PERSP, V112, P944, DOI 10.1289/ehp.6601 Costa LG, 2007, NEUROTOXICOLOGY, V28, P1047, DOI 10.1016/j.neuro.2007.08.007 Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880 Croen L.A., 2008, OBSTET GYNECOLOGY, V199, p234e1 Fisher Delbert A, 2007, Pediatr Endocrinol Rev, V4, P317 GILLBERG IC, 1992, J CHILD PSYCHOL PSYC, V33, P531, DOI 10.1111/j.1469-7610.1992.tb00889.x Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618 Grether JK, 2009, J AUTISM DEV DISORD, V39, P1412, DOI 10.1007/s10803-009-0754-z Haddow JE, 1999, NEW ENGL J MED, V341, P549, DOI 10.1056/NEJM199908193410801 HASHIMOTO T, 1991, DEV MED CHILD NEUROL, V33, P313 Herbstman J, 2008, THYROID, V18, P67, DOI [10.1089/thy.2007.0180, 10.1018/thy.2007.0180] Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483 Kahn A A, 1970, Br Med J, V4, P495 LaFranchi S, 1999, THYROID, V9, P735, DOI 10.1089/thy.1999.9.735 Langer Pavel, 2008, Endocr Regul, V42, P79 Lawler CP, 2004, MENT RETARD DEV D R, V10, P292, DOI 10.1002/mrdd.20043 London Eric, 2000, Environmental Health Perspectives, V108, P401, DOI 10.2307/3454527 McDonald TA, 2002, CHEMOSPHERE, V46, P745, DOI 10.1016/S0045-6535(01)00239-9 Morreale de Escobar G., 2004, J ENDOCRINOLOGY S3, V151, pU25 Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007 Nir I, 1995, J AUTISM DEV DISORD, V25, P641, DOI 10.1007/BF02178193 Pop VJ, 1999, CLIN ENDOCRINOL, V50, P149, DOI 10.1046/j.1365-2265.1999.00639.x Porterfield SP, 2000, ENVIRON HEALTH PERSP, V108, P433, DOI 10.2307/3454533 Roman GC, 2007, J NEUROL SCI, V262, P15, DOI 10.1016/j.jns.2007.06.023 Sadamatsu Miyuki, 2006, Congenital Anomalies, V46, P1, DOI 10.1111/j.1741-4520.2006.00094.x Soldin OP, 2003, THYROID, V13, P193, DOI 10.1089/105072503321319503 Suresh PA, 1999, PEDIATR NEUROL, V20, P192, DOI 10.1016/S0887-8994(98)00133-7 Van Meter KC, 2010, AUTISM RES, V3, P19, DOI 10.1002/aur.110 Wang SL, 2005, ENVIRON HEALTH PERSP, V113, P1645, DOI 10.1289/ehp.7994 WEISS RE, 1993, J PEDIATR-US, V123, P539, DOI 10.1016/S0022-3476(05)80947-3 Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120 NR 37 TC 9 Z9 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD DEC PY 2011 VL 4 IS 6 BP 456 EP 463 DI 10.1002/aur.219 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 858IK UT WOS:000297789500007 PM 21882364 ER PT J AU Bishop, SL Lahvis, GP AF Bishop, Somer L. Lahvis, Garet P. TI The Autism Diagnosis in Translation: Shared Affect in Children and Mouse Models of ASD SO AUTISM RESEARCH LA English DT Review ID FRAGILE-X-SYNDROME; CONDITIONED PLACE PREFERENCE; HIGH-FUNCTIONING AUTISM; MICE MUS-MUSCULUS; PERVASIVE DEVELOPMENTAL DISORDERS; PARENT-INFANT SYNCHRONY; SCENT MARKING BEHAVIOR; BTBR-T+TF/J MICE; ULTRASONIC VOCALIZATIONS; SPECTRUM DISORDERS AB In the absence of molecular biomarkers that can be used to diagnose ASD, current diagnostic tools depend upon clinical assessments of behavior. Research efforts with human subjects have successfully utilized standardized diagnostic instruments, which include clinician interviews with parents and direct observation of the children themselves [Risi et al., 2006]. However, because clinical instruments are semi-structured and rely heavily on dynamic social processes and clinical skill, scores from these measures do not necessarily lend themselves directly to experimental investigations into the causes of ASD. Studies of the neurobiology of autism require experimental animal models. Mice are particularly useful for elucidating genetic and toxicological contributions to impairments in social function [Halladay et al., 2009]. Behavioral tests have been developed that are relevant to autism [Crawley, 2004, 2007], including measures of repetitive behaviors [Lewis, Tanimura, Lee, & Bodfish, 2007; Moy et al., 2008], social behavior [Brodkin, 2007; Lijam et al., 1997; Moretti, Bouwknecht, Teague, Paylor, & Zoghbi, 2005], and vocal communication [D'Amato et al., 2005; Panksepp et al., 2007; Scattoni et al., 2008]. Advances also include development of high-throughput measures of mouse sociability that can be used to reliably compare inbred mouse strains [Moy et al., 2008; Nadler et al., 2004], as well as measures of social reward [Panksepp & Lahvis, 2007] and empathy [Chen, Panksepp, & Lahvis, 2009; Langford et al., 2006]. With continued generation of mouse gene-targeted mice that are directly relevant to genetic linkages in ASD, there remains an urgent need to utilize a full suite of mouse behavioral tests that allows for a comprehensive assessment of the spectrum of social difficulties relevant to ASD. Using impairments in shared affect as an example, this paper explores potential avenues for collaboration between clinical and basic scientists, within an amply considered translational framework. Autism Res 2011,4: 317-335. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Lahvis, Garet P.] Oregon Hlth & Sci Univ, Portland, OR 97239 USA. [Bishop, Somer L.] Cincinnati Childrens Hosp Med Ctr, Div Dev & Behav Pediat, Cincinnati, OH USA. RP Lahvis, GP (reprint author), Oregon Hlth & Sci Univ, 3181 SW Sam Jackson Pk Rd,Mail Code L470, Portland, OR 97239 USA. EM lahvisg@ohsu.edu FU NICHD [T32 HD07489, R03 HD046716, R01 HD065277-01]; NIDA [R01 DA022543]; NIH [T32 HD07489, R03 HD046716, R01 HD065277-01, R01 DA022543] FX Grant sponsor: NICHD; Grant numbers: T32 HD07489; R03 HD046716; R01 HD065277-01; Grant sponsor: NIDA; Grant number: R01 DA022543.We both express our gratitude to the Waisman Center at the University of Wisconsin-Madison for their enthusiastic encouragement of dialogue between clinicians and basic researchers. We thank Jules Panksepp for sharing the depth of his understanding of mouse social motivation and communication to our group. We also thank Katherine Baum and Jan Richards for their assistance with the preparation of this manuscript. We are grateful for the suggestions from our reviewers. This work represents a culmination of research experience that was supported by several funding sources that include the following NIH grants: T32 HD07489 (Abbeduto); R03 HD046716 (Lahvis); R01 DA022543 (Lahvis); R01 HD065277-01 (Bishop). CR Abarca C, 2002, P NATL ACAD SCI USA, V99, P9026, DOI 10.1073/pnas.142039099 Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005 American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th AMOROSA H, 1992, DISORDERS VOCAL SIGN ANDERSON PK, 1961, T NEW YORK ACAD SCI, V23, P447 Arakawa H, 2007, BEHAV BRAIN RES, V182, P73, DOI 10.1016/j.bbr.2007.05.007 Arakawa H, 2009, BEHAV BRAIN RES, V205, P138, DOI 10.1016/j.bbr.2009.07.007 Arakawa H, 2008, NEUROSCI BIOBEHAV R, V32, P1236, DOI 10.1016/j.neubiorev.2008.05.012 Baack JK, 2000, ETHOLOGY, V106, P1057, DOI 10.1046/j.1439-0310.2000.00619.x Bardo MT, 2000, PSYCHOPHARMACOLOGY, V153, P31, DOI 10.1007/s002130000569 Barrett S, 1999, AM J MED GENET, V88, P609 BARTHELEMY C, 1990, J AUTISM DEV DISORD, V20, P189, DOI 10.1007/BF02284718 Barthelemy M, 2004, NATURWISSENSCHAFTEN, V91, P135, DOI 10.1007/s00114-004-0501-4 Bazhenova OV, 2007, INT J PSYCHOPHYSIOL, V63, P64, DOI 10.1016/j.ijpsycho.2006.08.008 Bernieri F. J., 1991, FUNDAMENTALS NONVERB, P401 Bishop S, 2007, J CHILD PSYCHOL PSYC, V48, P1111, DOI 10.1111/j.1469-7610.2007.01782.x BLIZARD DA, 1992, BEHAV GENET, V22, P621, DOI 10.1007/BF01066634 Branchi I, 2001, BEHAV BRAIN RES, V125, P49, DOI 10.1016/S0166-4328(01)00277-7 Branchi I, 1998, DEV PSYCHOBIOL, V33, P249, DOI 10.1002/(SICI)1098-2302(199811)33:3<249::AID-DEV5>3.0.CO;2-R Brodkin ES, 2008, BEHAV NEUROSCI, V122, P483, DOI 10.1037/0735-7044.122.2.483 Brodkin ES, 2007, BEHAV BRAIN RES, V176, P53, DOI 10.1016/j.bbr.2006.06.025 Bryson SE, 2008, J AUTISM DEV DISORD, V38, P731, DOI 10.1007/s10803-007-0440-y Bult CJ, 2004, NUCLEIC ACIDS RES, V32, pD476, DOI 10.1093/nar/gkh125 Burgdorf J, 2008, J COMP PSYCHOL, V122, P357, DOI 10.1037/a0012889 Cabral A, 2006, EXP NEUROL, V200, P200, DOI 10.1016/j.expneurol.2006.02.004 CALCAGNETTI DJ, 1992, PHYSIOL BEHAV, V51, P667, DOI 10.1016/0031-9384(92)90101-7 Camacho F, 2004, PHARMACOL BIOCHEM BE, V78, P419, DOI 10.1016/j.pbb.2004.04.015 Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103 Carola V, 2002, BEHAV BRAIN RES, V134, P49, DOI 10.1016/S0166-4328(01)00452-1 Celani G, 1999, J AUTISM DEV DISORD, V29, P57, DOI 10.1023/A:1025970600181 Charman T, 2005, BEHAV BRAIN SCI, V28, P695 Charman T, 1998, INF MENTAL HLTH J, V19, P260, DOI 10.1002/(SICI)1097-0355(199822)19:2<260::AID-IMHJ12>3.0.CO;2-W Chen QL, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004387 Chen YH, 2009, J AUTISM DEV DISORD, V39, P635, DOI 10.1007/s10803-008-0663-6 Choleris E, 1997, BEHAV PROCESS, V41, P69, DOI 10.1016/S0376-6357(97)00029-6 Comery TA, 1997, P NATL ACAD SCI USA, V94, P5401, DOI 10.1073/pnas.94.10.5401 Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x CRAWLEY JN, 1975, BEHAV BIOL, V15, P73, DOI 10.1016/S0091-6773(75)92105-7 Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039 Crowcroft P., 1966, MICE ALL D'Amato FR, 2005, BEHAV GENET, V35, P103, DOI 10.1007/s10519-004-0860-9 Darwin C, 1872, EXPRESSION EMOTIONS Dastur FN, 1999, EUR J PHARMACOL, V382, P53, DOI 10.1016/S0014-2999(99)00590-7 DAWSON G, 1990, J ABNORM CHILD PSYCH, V18, P335, DOI 10.1007/BF00916569 Dawson G, 2004, DEVELOPMENTAL SCI, V7, P340, DOI 10.1111/j.1467-7687.2004.00352.x DELONG KT, 1967, ECOLOGY, V48, P611, DOI 10.2307/1936505 de Vrij FMS, 2008, NEUROBIOL DIS, V31, P127, DOI 10.1016/j.nbd.2008.04.002 DIEHL JJ, 2008, DISS ABSTR INT B DIXON AK, 1976, Z TIERPSYCHOL, V41, P225 Douglas LA, 2004, DEV PSYCHOBIOL, V45, P153, DOI 10.1002/dev.20025 EGGERT F, 1989, NEUROPSYCHOBIOLOGY, V22, P57, DOI 10.1159/000118592 EISENBERG N, 2006, NOVARTIS FDN S, V278 EKMAN P, 1990, J PERS SOC PSYCHOL, V58, P342, DOI 10.1037/0022-3514.58.2.342 ELWOOD RW, 1990, DEV PSYCHOBIOL, V23, P309, DOI 10.1002/dev.420230403 Falls WA, 1997, BEHAV NEUROSCI, V111, P855, DOI 10.1037/0735-7044.111.4.855 Feldman R, 2007, CURR DIR PSYCHOL SCI, V16, P340, DOI 10.1111/j.1467-8721.2007.00532.x Feldman R, 2007, J CHILD PSYCHOL PSYC, V48, P329, DOI 10.1111/j.1469-7610.2006.01701.x Field T, 2007, INFANT BEHAV DEV, V30, P431, DOI 10.1016/j.infbeh.2006.12.011 Fish EW, 2000, PSYCHOPHARMACOLOGY, V149, P277, DOI 10.1007/s002130000370 FREDERICKSEN J, 2007, ETHOLOGY ECOLOGY EVO, V19 FRYER AE, 1987, LANCET, V1, P659 GILDER PM, 1978, NATURE, V274, P364, DOI 10.1038/274364a0 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 HAGERMAN RJ, 1986, AM J MED GENET, V23, P359, DOI 10.1002/ajmg.1320230128 Halladay AK, 2009, NEUROTOXICOLOGY, V30, P811, DOI 10.1016/j.neuro.2009.07.002 Harris SW, 2008, AM J MENT RETARD, V113, P427, DOI 10.1352/2008.113:427-438 Hayashi ML, 2007, P NATL ACAD SCI USA, V104, P11489, DOI 10.1073/pnas.0705003104 Heeman P. A., 2010, 11 ANN M SPEC INT GR Hill DP, 2004, NUCLEIC ACIDS RES, V32, pD568, DOI 10.1093/nar/gkh069 Hiryu S, 2010, P NATL ACAD SCI USA, V107, P7048, DOI 10.1073/pnas.1000429107 Hiryu S, 2008, J COMP PHYSIOL A, V194, P841, DOI 10.1007/s00359-008-0355-x HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441 Hodgson SR, 2010, BEHAV PHARMACOL, V21, P112, DOI 10.1097/FBP.0b013e328337be25 HOFFMAN ML, 1975, DEV PSYCHOL, V11, P607, DOI 10.1037//0012-1649.11.5.607 Hofford RS, 2010, DRUG ALCOHOL DEPEN, V110, P263, DOI 10.1016/j.drugalcdep.2010.03.009 Hohoff C, 2009, J NEURAL TRANSM, V116, P679, DOI 10.1007/s00702-009-0215-z Holsboer F, 2001, BIOL PSYCHOL, V57, P47, DOI 10.1016/S0301-0511(01)00089-8 Holy TE, 2005, PLOS BIOL, V3, P2177, DOI 10.1371/journal.pbio.0030386 Hunsberger JG, 2007, NAT MED, V13, P1476, DOI 10.1038/nm1669 HURST JL, 1992, BEHAV ECOL, V3, P196, DOI 10.1093/beheco/3.3.196 Hutman T, 2010, J CHILD PSYCHOL PSYC, V51, P1010, DOI 10.1111/j.1469-7610.2010.02270.x Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136 Jenkins WJ, 2003, HORM BEHAV, V43, P503, DOI 10.1016/S0018-506X(03)00031-X Joseph RM, 1997, J AUTISM DEV DISORD, V27, P385, DOI 10.1023/A:1025853321118 Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 KANDT RS, 1992, NAT GENET, V2, P37, DOI 10.1038/ng0992-37 Kanner L, 1943, NERV CHILD, V2, P217 Kato T, 2006, DRUG NEWS PERSPECT, V19, P597, DOI 10.1358/dnp.2006.19.10.1068006 Kavaliers M, 2005, NEUROSCI BIOBEHAV R, V29, P1347, DOI 10.1016/j.neubiorev.2005.04.011 KAVALIERS M, 1995, ANIM BEHAV, V50, P1161, DOI 10.1016/0003-3472(95)80032-8 Kelley AE, 2002, J NEUROSCI, V22, P3306 Kelley AE, 2002, PHYSIOL BEHAV, V76, P365, DOI 10.1016/S0031-9384(02)00751-5 Kennedy BC, 2011, BEHAV PHARMACOL, V22, P147, DOI 10.1097/FBP.0b013e328343d7dd Klin A, 2008, BIOL PSYCHIAT, V64, P549, DOI 10.1016/j.biopsych.2008.07.028 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895 Knutson B, 1999, PHYSIOL BEHAV, V66, P639, DOI 10.1016/S0031-9384(98)00337-0 Kooy RF, 1996, AM J MED GENET, V64, P241, DOI 10.1002/(SICI)1096-8628(19960809)64:2<241::AID-AJMG1>3.0.CO;2-X KREBS CJ, 1995, OIKOS, V73, P429, DOI 10.2307/3545972 Kurian JR, 2008, J NEUROSCI, V28, P7137, DOI 10.1523/JNEUROSCI.1345-08.2008 LAHVIS GP, 2011, NEUROMETHODS, V50, P53 Lahvis GP, 2011, GENES BRAIN BEHAV, V10, P4, DOI 10.1111/j.1601-183X.2010.00603.x Langford DJ, 2010, NAT METHODS, V7, P447, DOI [10.1038/nmeth.1455, 10.1038/NMETH.1455] Langford DJ, 2006, SCIENCE, V312, P1967, DOI 10.1126/science.1128322 Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137 LEDOUX JE, 1988, J NEUROSCI, V8, P2517 Lewis MH, 2007, BEHAV BRAIN RES, V176, P66, DOI 10.1016/j.bbr.2006.08.023 Lijam N, 1997, CELL, V90, P895, DOI 10.1016/S0092-8674(00)80354-2 Liu XQ, 2008, BIOL PSYCHIAT, V64, P561, DOI 10.1016/j.biopsych.2008.05.023 Loat CS, 2008, GENES BRAIN BEHAV, V7, P754, DOI 10.1111/j.1601-183X.2008.00414.x LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lord C, 2001, AM J MED GENET, V105, P36, DOI 10.1002/1096-8628(20010108)105:1<36::AID-AJMG1053>3.0.CO;2-4 Low K, 2000, SCIENCE, V290, P131, DOI 10.1126/science.290.5489.131 MacLean P. D., 1990, TRIUNE BRAIN EVOLUTI Maestro S, 2002, J AM ACAD CHILD PSY, V41, P1239, DOI 10.1097/01.CHI.0000020277.43550.02 Maestro S, 2005, PSYCHOPATHOLOGY, V38, P26, DOI 10.1159/000083967 Markova G, 2006, DEV PSYCHOL, V42, P132, DOI 10.1037/0012-1649.42.1.132 MARTINEZ M, 1995, PHYSIOL BEHAV, V58, P323, DOI 10.1016/0031-9384(95)00061-M Mateo JM, 1996, ANIM BEHAV, V52, P489, DOI 10.1006/anbe.1996.0192 Mattson BJ, 2005, NEUROSCIENCE, V135, P315, DOI 10.1016/j.neuroscience.2005.06.045 Mattson BJ, 2001, BEHAV NEUROSCI, V115, P683, DOI 10.1037//0735-7044.115.3.683 McCann J, 2007, INT J LANG COMM DIS, V42, P682, DOI 10.1080/13682820601170102 McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x McNaughton CH, 2008, BEHAV NEUROSCI, V122, P293, DOI [10.1037/0735-7044.122.2.293, 10.1037/0735-7044A22.2.293] Meltzoff AN, 2007, ACTA PSYCHOL, V124, P26, DOI 10.1016/j.actpsy.2006.09.005 MEYER KJ, NATURE GENETICS, V39, P319 Moles A, 2004, SCIENCE, V304, P1983, DOI 10.1126/science.1095943 Moretti P, 2005, HUM MOL GENET, V14, P205, DOI 10.1093/hmg/ddi016 Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029 Nadler JJ, 2004, GENES BRAIN BEHAV, V3, P303, DOI 10.1111/j.1601-183X.2004.00071.x Nelson CA, 2008, J AM ACAD CHILD PSY, V47, P1252, DOI 10.1097/CHI.0b013e318185a6d8 Nelson EE, 2005, PSYCHOL MED, V35, P163, DOI 10.1017/S0033291704003915 NOYES RF, 1982, BEHAV ECOL SOCIOBIOL, V10, P157, DOI 10.1007/BF00299679 NYBY J, 1983, BEHAV NEURAL BIOL, V39, P128, DOI 10.1016/S0163-1047(83)90722-7 NYBY J, 1981, J COMP PHYSIOL PSYCH, V95, P623, DOI 10.1037/h0077794 NYBY J, 1977, ANIM BEHAV, V25, P333, DOI 10.1016/0003-3472(77)90009-4 Okazaki Y, 2002, NATURE, V420, P563, DOI 10.1038/nature01266 OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225 Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009 Panksepp J, 1998, AFFECTIVE NEUROSCIEN Panksepp JB, 2007, GENES BRAIN BEHAV, V6, P661, DOI 10.1111/j.1601-183X.2006.00295.x Panksepp JB, 2008, BEHAV BRAIN RES, V195, P239, DOI 10.1016/j.bbr.2008.09.010 Panksepp JB, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000351 Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9 Perona MTG, 2008, BEHAV PHARMACOL, V19, P566, DOI 10.1097/FBP.0b013e32830cd80f Pezet S, 2004, EXPERT OPIN THER TAR, V8, P391, DOI 10.1517/14728222.8.5.391 RALLS K, 1971, SCIENCE, V171, P443, DOI 10.1126/science.171.3970.443 REITH MEA, 1992, PHARMACOL BIOCHEM BE, V41, P227, DOI 10.1016/0091-3057(92)90087-V Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e Rogers SJ, 2001, J DEV BEHAV PEDIATR, V22, P409 Rossant J, 2001, TRENDS MOL MED, V7, P502, DOI 10.1016/S1471-4914(01)02164-5 ROTTMAN SJ, 1972, J COMP PHYSIOL PSYCH, V81, P483, DOI 10.1037/h0033703 Rupniak NMJ, 2001, BEHAV PHARMACOL, V12, P497 Rutter M., 2003, AUTISM DIAGNOSTIC IN Sadananda M, 2008, NEUROSCI LETT, V435, P17, DOI 10.1016/j.neulet.2008.02.002 SANDNABBA NK, 1986, BEHAV PROCESS, V12, P349, DOI 10.1016/0376-6357(86)90004-5 Scambler DJ, 2007, J AUTISM DEV DISORD, V37, P553, DOI 10.1007/s10803-006-0186-y Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067 SCOTT JP, 1966, AM ZOOL, V6, P683 Shahbazian MD, 2002, NEURON, V35, P243, DOI 10.1016/S0896-6273(02)00768-7 SHAPIRO T, 1991, PSYCHIAT CLIN N AM, V14, P19 Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087) Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851 Slobodchikoff CN, 2009, ANIM COGN, V12, P435, DOI 10.1007/s10071-008-0203-y Spencer CA, 2008, BEHAV NEUROSCI, V122, P710, DOI 10.1037/0735-7044.122.3.710 Spencer CM, 2011, AUTISM RES, V4, P40, DOI 10.1002/aur.168 Spencer CM, 2006, HUM MOL GENET, V15, P1984, DOI 10.1093/hmg/ddl121 Stern D., 1985, INTERPERSONAL WORLD Stone EA, 2008, NEUROSCI BIOBEHAV R, V32, P508, DOI 10.1016/j.neubiorev.2007.08.007 Stone WL, 2000, J AUTISM DEV DISORD, V30, P607, DOI 10.1023/A:1005647629002 Szatmari P, 2007, NAT GENET, V39, P1285 Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221 Takahashi A, 2008, GENES BRAIN BEHAV, V7, P849, DOI 10.1111/j.1601-183X.2008.00419.x THOMAS AM, 2011, BEHAV BRAIN IN PRESS Tomasello M, 2005, BEHAV BRAIN SCI, V28, P675, DOI 10.1017/S0140525X05000129 Trevarthen C, 2001, J CHILD PSYCHOL PSYC, V42, P3, DOI 10.1017/S0021963001006552 Turakainen H, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004341 Van Ree JM, 1999, PHARMACOL REV, V51, P341 VEERARAGAVAN S, 2011, PSYCHOPHARMACOLOGY B, DOI DOI 10.1007/S00213-011-2276-6 Volkmar FR, 2004, J CHILD PSYCHOL PSYC, V45, P135, DOI 10.1046/j.0021-9630.2003.00317.x Wang HR, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001893 WHALEN PJ, 2004, SCIENCE, V306, P17 Wing L, 2002, J CHILD PSYCHOL PSYC, V43, P307, DOI 10.1111/1469-7610.00023 WING L, 1979, J AUTISM DEV DISORD, V9, P11, DOI 10.1007/BF01531288 Wiznitzer M, 2004, J CHILD NEUROL, V19, P675 WOLFF RJ, 1985, J ZOOL, V207, P43 Yan QJ, 2005, NEUROPHARMACOLOGY, V49, P1053, DOI 10.1016/j.neuropharm.2005.06.004 Yang M, 2009, EUR J NEUROSCI, V29, P1663, DOI 10.1111/j.1460-9568.2009.06714.x Yang M, 2007, INT J DEV NEUROSCI, V25, P515, DOI 10.1016/j.ijdevneu.2007.09.008 YIRMIYA N, 1989, J CHILD PSYCHOL PSYC, V30, P725, DOI 10.1111/j.1469-7610.1989.tb00785.x Zhang AY, 2009, BIOCHEM BIOPH RES CO, V379, P920, DOI 10.1016/j.bbrc.2008.12.172 Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001 NR 194 TC 11 Z9 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2011 VL 4 IS 5 BP 317 EP 335 DI 10.1002/aur.216 PG 19 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 836XX UT WOS:000296153500001 PM 21882361 ER PT J AU Zaidman-Zait, A Mirenda, P Zumbo, BD Georgiades, S Szatmari, P Bryson, S Fombonne, E Roberts, W Smith, I Vaillancourt, T Volden, J Waddell, C Zwaigenbaum, L Duku, E Thompson, A AF Zaidman-Zait, Anat Mirenda, Pat Zumbo, Bruno D. Georgiades, Stelios Szatmari, Peter Bryson, Susan Fombonne, Eric Roberts, Wendy Smith, Isabel Vaillancourt, Tracy Volden, Joanne Waddell, Charlotte Zwaigenbaum, Lonnie Duku, Eric Thompson, Ann CA Pathways ASD Study Team TI Factor Analysis of the Parenting Stress Index-Short Form With Parents of Young Children With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; parenting stress; factor analysis; Parenting Stress Index-Short Form ID BEHAVIOR PROBLEMS; MATERNAL STRESS; INTELLECTUAL DISABILITY; SYNDROME SPECIFICITY; SOCIAL SUPPORT; MOTHERS; IMPACT; TODDLERS; VALIDITY; FATHERS AB The primary purpose of this study was to examine the underlying factor structure of the Parenting Stress Index-Short Form (PSI-SF) in a large cohort of parents of young children with autism spectrum disorder (ASD). A secondary goal was to examine relationships between PSI-SF factors and autism severity, child behavior problems, and parental mental health variables that have been shown to be related to parental stress in previous research. A confirmatory factor analysis (CFA) was used to examine the three-factor structure described in the PSI-SF manual [Abidin, 1995]: parental distress, parent-child dysfunctional interaction, and difficult child. Results of the CFA indicated that the three-factor structure was unacceptable when applied to the study sample. Thus, an exploratory factor analysis was conducted and suggested a six-factor model as the best alternative for the PSI-SF index. Spearman's correlations revealed significant positive correlations with moderate to large effect sizes between the revised PSI-SF factors and autism severity, externalizing and internalizing child behaviors, and an index of parent mental health. The revised factors represent more narrowly defined aspects of the three original subscales of the PSI-SF and might prove to be advantageous in both research and clinical applications. Autism Res 2011,4: 336-346. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Zaidman-Zait, Anat; Mirenda, Pat; Zumbo, Bruno D.] Univ British Columbia, Vancouver, BC V6T 1Z3, Canada. [Georgiades, Stelios; Szatmari, Peter; Duku, Eric; Thompson, Ann] McMaster Univ, Hamilton, ON, Canada. [Bryson, Susan; Smith, Isabel] Dalhousie Univ, IWK Hlth Sci Ctr, Halifax, NS, Canada. [Fombonne, Eric] McGill Univ, Montreal, PQ, Canada. [Roberts, Wendy] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada. [Vaillancourt, Tracy] Univ Ottawa, Ottawa, ON, Canada. [Volden, Joanne; Zwaigenbaum, Lonnie] Univ Alberta, Edmonton, AB, Canada. [Waddell, Charlotte] Simon Fraser Univ, Burnaby, BC V5A 1S6, Canada. RP Zaidman-Zait, A (reprint author), Univ British Columbia, 440-2206 East Mall, Vancouver, BC V6T 1Z3, Canada. EM anat.zaidman@ubc.ca RI Vaillancourt, Tracy/F-8949-2015 FU Canadian Institutes of Health Research; Autism Speaks; The Government of British Columbia; The Alberta Heritage Foundation for Medical Research; The Sinneave Family Foundation FX Grant sponsors: Canadian Institutes of Health Research; Autism Speaks; The Government of British Columbia; The Alberta Heritage Foundation for Medical Research; The Sinneave Family Foundation. CR Abidin RR, 1995, PARENTING STRESS IND ABIDIN RR, 1990, J CLIN CHILD PSYCHOL, V19, P298, DOI 10.1207/s15374424jccp1904_1 Achenbach T. M., 2000, MANUAL ASEBA PRESCHO American Psychiatric Association, 2000, DIAGN STAT MAN MENT Baker-Ericzen MJ, 2005, RES PRACT PERS SEV D, V30, P194, DOI 10.2511/rpsd.30.4.194 Baxter C, 2000, J INTELLECT DEV DIS, V25, P105 Beck A, 2004, J INTELLECT DEV DIS, V29, P339, DOI 10.1080/13668250400014509 Benson PR, 2009, J AUTISM DEV DISORD, V39, P350, DOI 10.1007/s10803-008-0632-0 Blacher J, 2006, J INTELL DISABIL RES, V50, P184, DOI 10.1111/j.1365-2788.2005.00768.x Brown T. A., 2006, CONFIRMATORY FACTOR Byrne B. M., 2006, STRUCTURAL EQUATION, V2nd Chang Y, 2007, J FAM PSYCHOL, V21, P584, DOI 10.1037/0893-3200.21.4.584 Cohen J, 1992, PSYCHOL BULL, V112, P115 Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 Constantino JN, 2005, SOCIAL RESPONSIVENES DeaterDeckard K, 1996, J FAM PSYCHOL, V10, P45, DOI 10.1037/0893-3200.10.1.45 Deater-Deckard K, 1998, CLIN PSYCHOL-SCI PR, V5, P314 Derogatis L., 1994, SCL 90 R ADM SCORING Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x Gadermann AM, 2011, SOC INDIC RES, V100, P37, DOI 10.1007/s11205-010-9603-x GILL MJ, 1991, J AUTISM DEV DISORD, V21, P407, DOI 10.1007/BF02206867 GRAY DE, 1994, SOCIOL HEALTH ILL, V16, P275, DOI 10.1111/1467-9566.ep11348729 Gray DE, 2002, J INTELLECT DEV DIS, V27, P215, DOI 10.1080/1366825021000008639 Haig BD, 2005, MULTIVAR BEHAV RES, V40, P303, DOI 10.1207/s15327906mbr4003_2 Haskett ME, 2006, J CLIN CHILD ADOLESC, V35, P302, DOI 10.1207/s15374424jccp3502_14 Hastings RP, 2003, J INTELL DISABIL RES, V47, P231, DOI 10.1046/j.1365-2788.2003.00485.x Hodapp RM, 1998, J INTELL DISABIL RES, V42, P331, DOI 10.1046/j.1365-2788.1998.00148.x Hopwood CJ, 2010, PERS SOC PSYCHOL REV, V14, P332, DOI 10.1177/1088868310361240 Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118 Hutton A. M., 2005, FOCUS AUTISM OTHER D, V20, P180, DOI [10.1177/10883576050200030601, DOI 10.1177/10883576050200030601] Kane M., 2006, ED MEASUREMENT, V4th, P17 Lecavalier L, 2006, J INTELL DISABIL RES, V50, P172, DOI 10.1111/j.1365-2788.2005.00732.x Lord C., 2002, AUTISM DIAGNOSTIC OB LOYD BH, 1985, J PEDIATR PSYCHOL, V10, P169, DOI 10.1093/jpepsy/10.2.169 McKelvey LM, 2009, J CHILD FAM STUD, V18, P102, DOI 10.1007/s10826-008-9211-4 MESSICK S, 1995, AM PSYCHOL, V50, P741, DOI 10.1037/0003-066X.50.9.741 MIRENDA P, 2005, AUT SOC AM ANN C NAS Montes G., 2008, PEDIATRICS, V122, P202, DOI DOI 10.1542/PEDS.2007-3037 Mullen E, 1995, MULLEN SCALES EARLY Muthen B, 1997, ROBUST INFERENCE USI Muthen L. K., 2007, M PLUS USERS GUIDE Osborne LA, 2008, J AUTISM DEV DISORD, V38, P1092, DOI 10.1007/s10803-007-0497-7 Osborne LA, 2008, RES AUTISM SPECT DIS, V2, P707, DOI 10.1016/j.rasd.2008.02.005 Pandolfi V, 2009, J AUTISM DEV DISORD, V39, P986, DOI 10.1007/s10803-009-0716-5 Perry A., 2004, J DEV DISABILITIES, V11, P1 Rao PA, 2009, BEHAV MODIF, V33, P437, DOI 10.1177/0145445509336427 Reitman D, 2002, J CLIN CHILD ADOLESC, V31, P384, DOI 10.1207/153744202760082649 ROBBINS FR, 1991, J EARLY INTERVENTION, V15, P173 Roid G. H., 2004, MERRILLPALMER REVISE Russell DW, 2002, PERS SOC PSYCHOL B, V28, P1629, DOI 10.1177/014616702237645 Rutter M., 2003, AUTISM DIAGNOSTIC IN Schopler E., 1988, CHILDHOOD AUTISM RAT Schumacker RE, 2004, BEGINNERS GUIDE STRU, V2nd Sparrow SS, 2005, VINELAND ADAPTIVE BE Stevens J. P., 2009, APPL MULTIVARIATE ST, V5th Stores R, 1998, J INTELL DISABIL RES, V42, P228, DOI 10.1046/j.1365-2788.1998.00123.x Tomanik S, 2004, J INTELLECT DEV DIS, V29, P16, DOI 10.1080/13668250410001662892 Weiss MJ, 2002, AUTISM, V6, P115, DOI 10.1177/1362361302006001009 Whiteside-Mansell L, 2007, PARENT-SCI PRACT, V7, P27, DOI 10.1207/s15327922par0701_2 Zaidman-Zait A, 2010, J CHILD PSYCHOL PSYC, V51, P1269, DOI 10.1111/j.1469-7610.2010.02266.x ZIMMERMAN DW, 1993, EDUC PSYCHOL MEAS, V53, P897, DOI 10.1177/0013164493053004003 Zimmerman I., 2002, PRESCHOOL LANGUAGE S, V4th Zimmerman I.L., 1992, PRESCHOOL LANGUAGE S Zumbo BD, 2009, CONCEPT OF VALIDITY: REVISIONS, NEW DIRECTIONS AND APPLICATIONS, P65 Zumbo BD, 2007, HANDB STAT, V26, P45, DOI 10.1016/S0169-7161(06)26003-6 NR 66 TC 2 Z9 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2011 VL 4 IS 5 BP 336 EP 346 DI 10.1002/aur.213 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 836XX UT WOS:000296153500002 PM 21882359 ER PT J AU Jones, CRG Swettenham, J Charman, T Marsden, AJS Tregay, J Baird, G Simonoff, E Happe, F AF Jones, Catherine R. G. Swettenham, John Charman, Tony Marsden, Anita J. S. Tregay, Jenifer Baird, Gillian Simonoff, Emily Happe, Francesca TI No Evidence for a Fundamental Visual Motion Processing Deficit In Adolescents with Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE motion coherence; form-from-motion; biological motion; point light display; mentalizing; theory of mind; autism spectrum disorders ID SUPERIOR TEMPORAL SULCUS; BIOLOGICAL MOTION; ASPERGER-SYNDROME; SOCIAL-PERCEPTION; WILLIAMS-SYNDROME; BRAIN MECHANISMS; COHERENT MOTION; ANIMATED SHAPES; MENTAL STATES; CHILDREN AB It has been suggested that atypicalities in low-level visual processing contribute to the expression and development of the unusual cognitive and behavioral profile seen in autism spectrum disorders (ASD). However, previous investigations have yielded mixed results. In the largest study of its kind (ASD n = 589; non-ASD = 552; mean age 15 years 6 months) and testing across the spectrum of IQ (range 52-133), we investigated performance on three measures of basic visual processing: motion coherence, form-from-motion and biological motion (BM). At the group level, we found no evidence of differences between the two groups on any of the tasks, suggesting that there is no fundamental visual motion processing deficit in individuals with an ASD, at least by adolescence. However, we identified a tail of individuals with ASD (18% of the sample) who had exceptionally poor BM processing abilities compared to the non-ASD group, and who were characterized by low IQ. For the entire sample of those both with and without ASD, performance on the BM task uniquely correlated with performance on the Frith-Happe animations, a higher-level task that demands the interpretation of moving, interacting agents in order to understand mental states. We hypothesize that this association reflects the shared social-cognitive characteristics of the two tasks, which have a common neural underpinning in the superior temporal sulcus. Autism Res 2011,4: 347-357. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Jones, Catherine R. G.] Univ Essex, Dept Psychol, Colchester CO4 3SQ, Essex, England. [Swettenham, John] UCL, Dept Dev Sci, London, England. [Charman, Tony] Ctr Res Autism & Educ, Dept Psychol & Human Dev, Inst Educ, London, England. [Marsden, Anita J. S.; Tregay, Jenifer] UCL Inst Child Hlth, London, England. [Baird, Gillian] Guys & St Thomas NHS Fdn Trust, London, England. [Simonoff, Emily] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London, England. [Happe, Francesca] Kings Coll London, Inst Psychiat, MRC SDGP Res Ctr, London, England. RP Jones, CRG (reprint author), Univ Essex, Dept Psychol, Colchester CO4 3SQ, Essex, England. EM crgjones@essex.ac.uk RI Happe, Francesca/D-5544-2012; Simonoff, Emily/B-7593-2011; Jones, Catherine/E-4956-2013; Charman, Tony/A-2085-2014 OI Charman, Tony/0000-0003-1993-6549 FU Medical Research Council [G0400065]; Clothworkers' Foundation; Pears Foundation FX Grant sponsor: Medical Research Council; Grant number: G0400065; Grant sponsors: Clothworkers' Foundation; Pears Foundation. CR Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9 Allison T, 2000, TRENDS COGN SCI, V4, P267, DOI 10.1016/S1364-6613(00)01501-1 Annaz D, 2010, DEVELOPMENTAL SCI, V13, P826, DOI 10.1111/j.1467-7687.2009.00939.x Atkinson AP, 2009, NEUROPSYCHOLOGIA, V47, P3023, DOI 10.1016/j.neuropsychologia.2009.05.019 Atkinson J, 1997, NEUROREPORT, V8, P1919, DOI 10.1097/00001756-199705260-00025 Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Bertone A, 2003, J COGNITIVE NEUROSCI, V15, P218, DOI 10.1162/089892903321208150 Bertone A, 2008, NEUROREPORT, V19, P225, DOI 10.1097/WNR.0b013e3282f48401 Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434 Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016 Braddick O, 2003, NEUROPSYCHOLOGIA, V41, P1769, DOI 10.1016/S0028-3932(03)00178-7 Braddick OJ, 2000, CURR BIOL, V10, P731, DOI 10.1016/S0960-9822(00)00540-6 Brieber S, 2010, NEUROPSYCHOLOGIA, V48, P1644, DOI 10.1016/j.neuropsychologia.2010.02.007 Castelli F, 2000, NEUROIMAGE, V12, P314, DOI 10.1006/nimg.2000.0612 Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189 Charman T, 2011, BRAIN RES, V1380, P10, DOI 10.1016/j.brainres.2010.10.075 Cornelissen PL, 1998, VISION RES, V38, P471, DOI 10.1016/S0042-6989(97)00199-5 Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018 de Jonge MV, 2007, NEUROPSYCHOLOGY, V21, P65, DOI 10.1037/0894-4105.21.1.65 Del Viva MM, 2006, VISION RES, V46, P1242, DOI 10.1016/j.visres.2005.10.018 Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025 Gobbini MI, 2007, J COGNITIVE NEUROSCI, V19, P1803, DOI 10.1162/jocn.2007.19.11.1803 Grinter EJ, 2010, BRAIN RES BULL, V82, P147, DOI 10.1016/j.brainresbull.2010.02.016 Grossman E, 2000, J COGNITIVE NEUROSCI, V12, P711, DOI 10.1162/089892900562417 Herrington JD, 2007, RES AUTISM SPECT DIS, V1, P14, DOI 10.1016/j.rasd.2006.07.002 Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y Jastorff J, 2009, J NEUROSCI, V29, P7315, DOI 10.1523/JNEUROSCI.4870-08.2009 JOHANSSO.G, 1973, PERCEPT PSYCHOPHYS, V14, P201, DOI 10.3758/BF03212378 Kaiser MD, 2010, AUTISM RES, V3, P191, DOI 10.1002/aur.137 Kaiser MD, 2009, PSYCHON B REV, V16, P761, DOI 10.3758/PBR.16.5.761 Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868 Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101 Koldewyn K, 2010, BRAIN, V133, P599, DOI 10.1093/brain/awp272 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Milne E, 2002, J CHILD PSYCHOL PSYC, V43, P255, DOI 10.1111/1469-7610.00018 Milne E, 2006, J AUTISM DEV DISORD, V36, P225, DOI 10.1007/s10803-005-0052-3 Moore DG, 1997, BRIT J DEV PSYCHOL, V15, P401 Murphy P, 2009, NEUROPSYCHOLOGIA, V47, P3225, DOI 10.1016/j.neuropsychologia.2009.07.026 NEWSOME WT, 1988, J NEUROSCI, V8, P99 Parron C, 2008, AUTISM, V12, P261, DOI 10.1177/1362361307089520 Pellicano E, 2005, NEUROPSYCHOLOGIA, V43, P1044, DOI 10.1016/j.neuropsychologia.2004.10.003 Pelphrey KA, 2008, ANN NY ACAD SCI, V1145, P283, DOI 10.1196/annals.1416.007 Pelphrey KA, 2003, J NEUROSCI, V23, P6819 Pyles JA, 2007, VISION RES, V47, P2786, DOI 10.1016/j.visres.2007.07.017 Reiss JE, 2005, VISION RES, V45, P3379, DOI 10.1016/j.visres.2005.05.011 Ridder WH, 2001, OPTOMETRY VISION SCI, V78, P510, DOI 10.1097/00006324-200107000-00014 Rutter M., 2003, SOCIAL COMMUNICATION Salter G, 2008, AUTISM, V12, P349, DOI 10.1177/1362361308091654 Saygin AP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013491 SELTZER B, 1978, BRAIN RES, V149, P1, DOI 10.1016/0006-8993(78)90584-X Spencer J, 2000, NEUROREPORT, V11, P2765, DOI 10.1097/00001756-200008210-00031 Taylor NM, 2009, NEUROPSYCHOLOGIA, V47, P2766, DOI 10.1016/j.neuropsychologia.2009.06.001 THIRKETTLE M, 2009, J VISION, V9, P11 Tsermentseli S, 2008, J AUTISM DEV DISORD, V38, P1201, DOI 10.1007/s10803-007-0500-3 Vachon P, 2009, INT J NEUROSCI, V119, P1584, DOI 10.1080/00207450802328367 Vaina LM, 2001, P NATL ACAD SCI USA, V98, P11656, DOI 10.1073/pnas.191374198 Wechsler D, 1999, WECHSLER ABBREVIATED White S, 2006, COGN NEUROPSYCHOL, V23, P748, DOI 10.1080/02643290500438607 NR 59 TC 24 Z9 25 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2011 VL 4 IS 5 BP 347 EP 357 DI 10.1002/aur.209 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 836XX UT WOS:000296153500003 PM 21850664 ER PT J AU Meirsschaut, M Warreyn, P Roeyers, H AF Meirsschaut, Mieke Warreyn, Petra Roeyers, Herbert TI What is the Impact of Autism on Mother-Child Interactions Within Families With A Child With Autism Spectrum Disorder? SO AUTISM RESEARCH LA English DT Article DE within-family design; mother-child interaction; Autism spectrum disorder ID MENTAL-RETARDATION; JOINT ATTENTION; YOUNG-CHILDREN; DIFFERENTIAL TREATMENT; SIBLING RELATIONSHIPS; PRESCHOOL-CHILDREN; LANGUAGE DISORDER; PARENTING STRESS; DOWNS-SYNDROME; COMMUNICATION AB This within-family study investigated whether mothers differentiate between children in their interactive behavior. Mothers were observed during a play and a task interaction separately with their child with autism spectrum disorder (ASD) (between 46 and 84 months old, M = 68) and with a younger sibling (between 29 and 67 months old, M = 48). Additionally, the social behavior of the children with ASD and their non-ASD siblings was compared. Results show that mothers differentiated in their responsiveness but not in their initiatives toward the children. Children with ASD and their non-ASD siblings were equally responsive but children with ASD were more imperative toward their caregiver. Several interpretations of these findings are discussed. Finally, it is concluded that family-based interventions will benefit from a better understanding of the effect of ASD on mother-child interactions within families with a child with ASD. Therefore, between-family studies should be complemented with within-family studies. Autism Res 2011,4: 358-367. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Meirsschaut, Mieke; Warreyn, Petra; Roeyers, Herbert] Univ Ghent, Res Grp Dev Disorders, B-9000 Ghent, Belgium. RP Meirsschaut, M (reprint author), Univ Ghent, Res Grp Dev Disorders, H Dunantlaan 2, B-9000 Ghent, Belgium. EM Mieke.Meirsschaut@arteveldehs.be CR Adamson LB, 2001, J APPL DEV PSYCHOL, V22, P439, DOI 10.1016/S0193-3973(01)00089-2 BELL RQ, 1986, DEV PSYCHOL, V22, P595, DOI 10.1037/0012-1649.22.5.595 Bruinsma Y, 2004, MENT RETARD DEV D R, V10, P169, DOI 10.1002/mrdd.20036 COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155 CORTER C, 1983, CHILD DEV, V54, P1599, DOI 10.1111/j.1467-8624.1983.tb00076.x CORTER C, 1992, CAN J BEHAV SCI, V24, P1, DOI 10.1037/h0078697 Dawson G, 2002, DEV PSYCHOPATHOL, V14, P581, DOI 10.1017/S0954579402003103 Deater-Deckard K, 2005, INFANT CHILD DEV, V14, P211, DOI 10.1002/icd.389 Doussard-Roosevelt JA, 2003, DEV PSYCHOPATHOL, V15, P277, DOI 10.1017/S0954579403000154 DUNN JF, 1986, CHILD DEV, V57, P348, DOI 10.1111/j.1467-8624.1986.tb00034.x Dunn L.M., 2005, PEABODY PICTURE VOCA Eisenhower AS, 2005, J INTELL DISABIL RES, V49, P657, DOI 10.1111/j.1365-2788.2005.00699.x Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658 Hollingshead A. A., 1975, 4 FACTOR INDEX UNPUB HOPPES K, 1990, J CLIN CHILD PSYCHOL, V19, P365, DOI 10.1207/s15374424jccp1904_8 Jackson CT, 2003, J AUTISM DEV DISORD, V33, P115, DOI 10.1023/A:1022927124025 KASARI C, 1993, DEV PSYCHOPATHOL, V5, P403, DOI 10.1017/S0954579400004491 Kasari C, 1997, J AUTISM DEV DISORD, V27, P39, DOI 10.1023/A:1025869105208 KASARI C, 1988, J ABNORM CHILD PSYCH, V16, P45, DOI 10.1007/BF00910499 Keen D, 2010, RES AUTISM SPECT DIS, V4, P229, DOI 10.1016/j.rasd.2009.09.009 LANDRY SH, 1994, DEV PSYCHOL, V30, P293 LEMANEK KL, 1993, J CLIN CHILD PSYCHOL, V22, P68, DOI 10.1207/s15374424jccp2201_7 Lord C., 1999, AUTISM DIAGNOSTIC OB Mahoney G, 2005, J DEV BEHAV PEDIATR, V26, P77, DOI 10.1097/00004703-200504000-00002 MARFO K, 1992, AM J ORTHOPSYCHIAT, V62, P219, DOI 10.1037/h0079334 McHale J, 2008, FAM PROCESS, V47, P445, DOI 10.1111/j.1545-5300.2008.00265.x MCHALE SM, 1989, DEV PSYCHOL, V25, P421, DOI 10.1037/0012-1649.25.3.421 MCHALE SM, 1992, CHILD DEV, V63, P68, DOI 10.1111/j.1467-8624.1992.tb03596.x Meirsschaut M, 2010, RES AUTISM SPECT DIS, V4, P661, DOI 10.1016/j.rasd.2010.01.002 Meirsschaut M, 2011, AUTISM, V15, P43, DOI 10.1177/1362361309353911 Montes G, 2007, PEDIATRICS, V119, pE1040, DOI 10.1542/peds.2006-2819 Mundy P, 2009, AUTISM RES, V2, P2, DOI 10.1002/aur.61 Murphy M, 2000, PSYCHOL MED, V30, P1411, DOI 10.1017/S0033291799002949 *NOLD, 2008, OBS XT NEXT GEN OBS Olsson MB, 2001, J INTELL DISABIL RES, V45, P535, DOI 10.1046/j.1365-2788.2001.00372.x Plomin R, 2001, CAN J PSYCHIAT, V46, P225 QUITTNER AL, 1994, CHILD DEV, V65, P800, DOI 10.1111/j.1467-8624.1994.tb00784.x Rao PA, 2009, BEHAV MODIF, V33, P437, DOI 10.1177/0145445509336427 Rivers JW, 2008, J AUTISM DEV DISORD, V38, P1740, DOI 10.1007/s10803-008-0560-z Rutgers AH, 2007, J ABNORM CHILD PSYCH, V35, P859, DOI 10.1007/s10802-007-9139-y Rutter M., 2003, AUTISM DIAGNOSTIC IN Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276 Spiker D, 2002, INT REV RES MENT RET, V25, P35, DOI 10.1016/S0074-7750(02)80005-2 Stone WL, 1997, J AUTISM DEV DISORD, V27, P677, DOI 10.1023/A:1025854816091 Taylor HB, 2008, EARLY EDUC DEV, V19, P188, DOI 10.1080/10409280701839304 Tellegen PJ, 1998, SNIJDERSOOMEN NIET V van IJzendoorn MH, 2007, CHILD DEV, V78, P597, DOI 10.1111/j.1467-8624.2007.01016.x Warreyn P., 2004, HANDLEIDING VRAGENLI Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4 Whiteman SD, 2003, J MARRIAGE FAM, V65, P608, DOI 10.1111/j.1741-3737.2003.00608.x WillemsenSwinkels SHN, 1997, J CHILD PSYCHOL PSYC, V38, P327, DOI 10.1111/j.1469-7610.1997.tb01517.x Wimpory DC, 2000, J AUTISM DEV DISORD, V30, P525, DOI 10.1023/A:1005683209438 NR 52 TC 2 Z9 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2011 VL 4 IS 5 BP 358 EP 367 DI 10.1002/aur.217 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 836XX UT WOS:000296153500004 PM 21882362 ER PT J AU Ellegood, J Lerch, JP Henkelman, RM AF Ellegood, Jacob Lerch, Jason P. Henkelman, R. Mark TI Brain Abnormalities in a Neuroligin3 R451C Knockin Mouse Model Associated With Autism SO AUTISM RESEARCH LA English DT Article DE animal models; magnetic resonance imaging; diffusion tensor imaging; neuroligin3; volume assessment ID CORPUS-CALLOSUM; DEVELOPMENTAL DISORDERS; BASAL GANGLIA; MICE; MRI; NLGN4; SCHIZOPHRENIA; HYPOPLASIA; SPECTRUM; MUTATION AB Magnetic resonance imaging (MRI) has been used quite extensively for examining morphological changes in human and animal brains. One of the many advantages to examining mouse models of human autism is that we are able to examine single gene targets, like that of Neuroligin3 R451C knockin (NL3 KI), which has been directly implicated in human autism. The NL3 KI mouse model has marked volume differences in many different structures in the brain: gray matter structures, such as the hippocampus, the striatum, and the thalamus, were all found to be smaller in the NL3 KI. Further, many white matter structures were found to be significantly smaller, such as the cerebral peduncle, corpus callosum, fornix/fimbria, and internal capsule. Fractional anisotropy measurements in these structures were also measured, and no differences were found. The volume changes in the white matter regions, therefore, are not due to a general breakdown in the microstructure of the tissue and seem to be caused by fewer axons or less mature axons. A larger radial diffusivity was also found in localized regions of the corpus callosum and cerebellum. The corpus callosal changes are particularly interesting as the thinning (or reduced volume) of the corpus callosum is a consistent finding in autism. This suggests that the NL3 KI model may be useful for examining white matter changes associated with autism. Autism Res 2011,4: 368-376. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Ellegood, Jacob] Hosp Sick Children, Toronto Ctr Phenogen, Mouse Imaging Ctr MICe, Toronto, ON M5T 3H7, Canada. RP Ellegood, J (reprint author), Hosp Sick Children, Toronto Ctr Phenogen, Mouse Imaging Ctr MICe, 25 Orde St, Toronto, ON M5T 3H7, Canada. EM jacob@phenogenomics.ca RI Henkelman, Mark/F-3662-2011 FU Canadian Institute for Health Research (CIHR) [MOP-106418]; Ontario Mental Health Foundation (OMHF) FX Grant sponsor: Canadian Institute for Health Research (CIHR); Grant number: MOP-106418; Grant sponsor: Ontario Mental Health Foundation (OMHF). CR Abrahams BS, 2010, ARCH NEUROL-CHICAGO, V67, P395, DOI 10.1001/archneurol.2010.47 ABRAHAMS BS, 2010, HUMAN GENETICS PROBL, P699 Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032 Alexander AL, 2007, NEUROTHERAPEUTICS, V4, P316, DOI 10.1016/j.nurt.2007.05.011 Aylward EH, 1999, NEUROLOGY, V53, P2145 BAILEY A, 1995, PSYCHOL MED, V25, P63 Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Benveniste H, 2006, LANCET NEUROL, V5, P536, DOI 10.1016/S1474-4422(06)70472-0 Bock NA, 2005, MAGNET RESON MED, V54, P1311, DOI 10.1002/mrm.20683 Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22 CHAKOS MH, 1994, AM J PSYCHIAT, V151, P1430 Cody H, 2002, INT J DEV NEUROSCI, V20, P421, DOI 10.1016/S0736-5748(02)00053-9 COLLINS DL, 1994, J COMPUT ASSIST TOMO, V18, P192 COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102 D'Arceuil H, 2007, NEUROIMAGE, V36, P64, DOI 10.1016/j.neuroimage.2007.02.039 Dorr AE, 2008, NEUROIMAGE, V42, P60, DOI 10.1016/j.neuroimage.2008.03.037 EGAAS B, 1995, ARCH NEUROL-CHICAGO, V52, P794 Ellegood J, 2010, NEUROIMAGE, V53, P1023, DOI 10.1016/j.neuroimage.2010.03.038 Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3 Genovese CR, 2002, NEUROIMAGE, V15, P870, DOI 10.1006/nimg.2001.1037 Hashimoto R, 2009, WORLD J BIOL PSYCHIA, V10, P65, DOI 10.1080/15622970701762536 Henkelman RM, 2006, MAGN RESON MED, V56, P1371, DOI 10.1002/mrm.21077 Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040 Hughes JR, 2007, EPILEPSY BEHAV, V11, P20, DOI 10.1016/j.yebeh.2007.03.010 Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136 Kirov G, 2008, HUM MOL GENET, V17, P458, DOI 10.1093/hmg/ddm323 Lau JC, 2008, NEUROIMAGE, V42, P19, DOI 10.1016/j.neuroimage.2008.04.252 Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137 Lawson-Yuen A, 2008, EUR J HUM GENET, V16, P614, DOI 10.1038/sj.ejhg.5202006 Le Bihan D, 2001, J MAGN RESON IMAGING, V13, P534, DOI 10.1002/jmri.1076 Lerch JP, 2011, NEUROIMAGE, V54, P2086, DOI 10.1016/j.neuroimage.2010.09.086 Lerch JP, 2008, NEUROIMAGE, V39, P32, DOI 10.1016/j.neuroimage.2007.08.033 MURAKAMI JW, 1989, ARCH NEUROL-CHICAGO, V46, P689 Nag N, 2009, BEHAV BRAIN RES, V196, P44, DOI 10.1016/j.bbr.2008.07.008 Nieman BJ, 2006, PHYSIOL GENOMICS, V24, P154, DOI 10.1152/physiolgenomics.00217.2005 Piven J, 1997, AM J PSYCHIAT, V154, P1051 Radyushkin K, 2009, GENES BRAIN BEHAV, V8, P416, DOI 10.1111/j.1601-183X.2009.00487.x Reiss AL, 2009, J CHILD PSYCHOL PSYC, V50, P87, DOI 10.1111/j.1469-7610.2008.02046.x Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56 Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2 Spring S, 2007, NEUROIMAGE, V35, P1424, DOI 10.1016/j.neuroimage.2007.02.023 Spring S, 2010, NEUROIMAGE, V50, P409, DOI 10.1016/j.neuroimage.2009.12.043 Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006 STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221 Verhoeven JS, 2010, NEURORADIOLOGY, V52, P3, DOI 10.1007/s00234-009-0583-y Zahir FR, 2008, J MED GENET, V45, P239, DOI 10.1136/jmg.2007.054437 NR 47 TC 21 Z9 22 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2011 VL 4 IS 5 BP 368 EP 376 DI 10.1002/aur.215 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 836XX UT WOS:000296153500005 PM 21882360 ER PT J AU Curran, S Dworzynski, K Happe, F Ronald, A Allison, C Baron-Cohen, S Brayne, C Bolton, PF AF Curran, Sarah Dworzynski, Katharina Happe, Francesca Ronald, Angelica Allison, Carrie Baron-Cohen, Simon Brayne, Carol Bolton, Patrick F. TI No Major Effect of Twinning on Autistic Traits SO AUTISM RESEARCH LA English DT Article DE clinical psychiatry; developmental psychology; diagnosis; epidemiology; social cognition ID TWINS EARLY DEVELOPMENT; AFFECTED SIBLING PAIRS; GENERAL-POPULATION; SINGLETON DIFFERENCES; SPECTRUM CONDITIONS; FETAL TESTOSTERONE; BEHAVIOR PROBLEMS; SEX-DIFFERENCES; CHILDHOOD; LANGUAGE AB Background: It has been questioned whether the process of twinning might be a risk factor for autism spectrum conditions (ASC) and autistic traits. Aim: We sought to determine whether autistic traits and probable disorder, as measured by the Childhood Autism Spectrum Test (CAST), were more pronounced in twins compared to singletons. Samples: Data were analyzed from two large population-based samples of UK children, twins (n = 5,142 twin pairs, aged 8 years) and singletons (n = 2,805, aged 5-9 years). Results: Distributions of CAST scores in both groups were negatively skewed and scores for twins were more variable than singletons. Mean CAST total scores and standard errors (SE) were not significantly different for twins (5.1; SE 0.04) compared to singletons (4.9; SE 0.08). Moreover, contrary to expectations, the likelihood of scoring above the threshold for possible ASC was significantly lower in the twins than the singletons (OR = 0.69; P = 0.002). Subsidiary analyses of CAST scores according to sex, twin type, and subscale scores representing the subdomains of autism found a few significant differences (P < 0.01), but the effect sizes for these differences were small and none exceeded eta(2) = 0.005. The explanation for these small differences remains obscure, but the very small effect sizes mean they are of little importance. Conclusions: Our results do not provide evidence to support twinning as a risk factor in the development of autistic traits. Autism Res 2011,4:377-382. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Curran, Sarah; Bolton, Patrick F.] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London SE5 8AF, England. [Curran, Sarah; Dworzynski, Katharina; Happe, Francesca; Ronald, Angelica; Bolton, Patrick F.] Kings Coll London, Inst Psychiat, MRC Social Genet Dev & Psychiat Res Ctr, London SE5 8AF, England. [Dworzynski, Katharina] Royal Coll Physicians, London, England. [Ronald, Angelica] Univ London, Birkbeck Coll, Sch Sci, Dept Psychol Sci, London WC1E 7HU, England. [Allison, Carrie; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England. [Bolton, Patrick F.] Kings Coll London, Inst Psychiat, NIHR Biomed Res Ctr Mental Hlth, London WC2R 2LS, England. [Brayne, Carol] Kings Coll London, Inst Publ Hlth, Dept Publ Hlth & Primary Care, London SE5 8AF, England. RP Curran, S (reprint author), Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, P055 Main Bldg,Crespigny Pk, London SE5 8AF, England. EM sarah.curran@kcl.ac.uk RI Happe, Francesca/D-5544-2012; Ronald, Angelica/C-7812-2009; Bolton, Patrick/E-8501-2010 OI Ronald, Angelica/0000-0002-9576-2176; Bolton, Patrick/0000-0002-5270-6262 FU Medical Research Council; UK NIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry, Kings College London; The South London and Maudsley NHS Foundation Trust; U.K. Medical Research Council [G0500079] FX This research was supported by grant funding from the Medical Research Council. Patrick Bolton is supported by the UK NIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry, Kings College London and The South London and Maudsley NHS Foundation Trust. We wish to thank all the children and families who gave their time to participate in this research. We gratefully acknowledge the ongoing contribution of the parents and children in the Twins Early Development Study (TEDS). TEDS is supported by a program grant (G0500079) from the U.K. Medical Research Council. CR Auyeung B, 2009, BRIT J PSYCHOL, V100, P1, DOI 10.1348/000712608X311731 BAILEY A, 1995, PSYCHOL MED, V25, P63 Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455 Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345 Baron-Cohen S, 2009, BRIT J PSYCHOL, V100, P39, DOI 10.1348/000712608X394271 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Betancur C, 2002, AM J HUM GENET, V70, P1381, DOI 10.1086/340364 BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524 Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950 Fombonne E, 2009, PEDIATR RES, V65, P591, DOI 10.1203/PDR.0b013e31819e7203 Giedd JN, 1996, CEREB CORTEX, V6, P551, DOI 10.1093/cercor/6.4.551 Greenberg DA, 2001, AM J HUM GENET, V69, P1062, DOI 10.1086/324191 Hallmayer J, 2002, AM J HUM GENET, V71, P941, DOI 10.1086/342990 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 Harden C L, 2000, J Gend Specif Med, V3, P33 Ho A, 2005, J AUTISM DEV DISORD, V35, P129, DOI 10.1007/s10803-004-1040-8 Hoekstra RA, 2007, ARCH PEDIAT ADOL MED, V161, P372, DOI 10.1001/archpedi.161.4.372 Huber H P, 1967, Arch Gesamte Psychol, V119, P288 Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6 Luu TM, 2009, AM J MED GENET C, V151C, P142, DOI 10.1002/ajmg.c.30208 Oliver BR, 2007, TWIN RES HUM GENET, V10, P96, DOI 10.1375/twin.10.1.96 Ronald A, 2006, J AM ACAD CHILD PSY, V45, P1206, DOI 10.1097/01.chi.0000230165.54117.41 Ronald A, 2010, CHILD DEV, V81, P166, DOI 10.1111/j.1467-8624.2009.01387.x Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d RUTTER M, 1991, J CHILD PSYCHOL PSYC, V32, P885, DOI 10.1111/j.1469-7610.1991.tb01916.x Rutter M, 2003, J CHILD PSYCHOL PSYC, V44, P326, DOI 10.1111/1469-7610.00125 Scott FJ, 2002, AUTISM, V6, P231, DOI 10.1177/1362361302006003002 SIMONOFF E, 1992, J CHILD PSYCHOL PSYC, V33, P1319, DOI 10.1111/j.1469-7610.1992.tb00952.x Sutcliffe AG, 2006, EARLY HUM DEV, V82, P379, DOI 10.1016/j.earlhumdev.2006.03.007 Trouton A, 2002, TWIN RES, V5, P444, DOI 10.1375/136905202320906255 Visscher PM, 2002, AM J HUM GENET, V71, P995, DOI 10.1086/342991 Williams J, 2005, AUTISM, V9, P45, DOI 10.1177/136261305049029 Williams JG, 2008, J AUTISM DEV DISORD, V38, P1731, DOI 10.1007/s10803-008-0558-6 NR 35 TC 6 Z9 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2011 VL 4 IS 5 BP 377 EP 382 DI 10.1002/aur.207 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 836XX UT WOS:000296153500006 PM 21766464 ER PT J AU David, N Schneider, TR Vogeley, K Engel, AK AF David, Nicole Schneider, Till R. Vogeley, Kai Engel, Andreas K. TI Impairments in Multisensory Processing are Not Universal to the Autism Spectrum: No Evidence for Crossmodal Priming Deficits in Asperger Syndrome SO AUTISM RESEARCH LA English DT Article DE Asperger syndrome; high-functioning autism; multisensory processing; crossmodal priming; local processing ID AUDIOVISUAL SPEECH INTEGRATION; FUNCTIONING AUTISM; VISUAL-PERCEPTION; CHILDREN; DISORDERS; PRECEDENCE; ATTENTION AB Individuals suffering from autism spectrum disorders (ASD) often show a tendency for detail-or feature-based perception (also referred to as "local processing bias'') instead of more holistic stimulus processing typical for unaffected people. This local processing bias has been demonstrated for the visual and auditory domains and there is evidence that multisensory processing may also be affected in ASD. Most multisensory processing paradigms used social-communicative stimuli, such as human speech or faces, probing the processing of simultaneously occuring sensory signals. Multisensory processing, however, is not limited to simultaneous stimulation. In this study, we investigated whether multisensory processing deficits in ASD persist when semantically complex but nonsocial stimuli are presented in succession. Fifteen adult individuals with Asperger syndrome and 15 control persons participated in a visual-audio priming task, which required the classification of sounds that were either primed by semantically congruent or incongruent preceding pictures of objects. As expected, performance on congruent trials was faster and more accurate compared with incongruent trials (crossmodal priming effect). The Asperger group, however, did not differ significantly from the control group. Our results do not support a general multisensory processing deficit, which is universal to the entire autism spectrum. Autism Res 2011,4: 383-388. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [David, Nicole; Schneider, Till R.; Engel, Andreas K.] Univ Med Ctr Hamburg Eppendorf, Dept Neurophysiol & Pathophysiol, D-20246 Hamburg, Germany. [Vogeley, Kai] Univ Cologne, Dept Psychiat & Psychotherapy, Cologne, Germany. RP David, N (reprint author), Univ Med Ctr Hamburg Eppendorf, Dept Neurophysiol & Pathophysiol, Martinistr 52, D-20246 Hamburg, Germany. EM ndavid@uke.de RI Engel, Andreas/C-7781-2012; Schneider, Till/B-3751-2010; David, Nicole/H-1682-2012; Vogeley, K/E-4860-2012 OI Engel, Andreas/0000-0003-4899-8466; Schneider, Till/0000-0002-8889-6248; Vogeley, K/0000-0002-5891-5831 FU BMBF [01 GW 0611, 01 GW 0561] FX Grant sponsor: BMBF; Grant numbers: 01 GW 0611; 01 GW 0561. CR Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643 Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002 Blakemore SJ, 2006, BRAIN COGNITION, V61, P5, DOI 10.1016/j.bandc.2005.12.013 Brock J, 2002, DEV PSYCHOPATHOL, V14, P209 Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018 Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271 De Gelder B, 1991, EUROPEAN J COGNITIVE, V3, P69, DOI 10.1080/09541449108406220 Foxton JM, 2003, BRAIN, V126, P2703, DOI 10.1093/brain/awg274 Grandin T, 2009, BIOL PSYCHIAT, V65, P15, DOI 10.1016/j.biopsych.2008.11.005 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Lane AE, 2011, J AUTISM DEV DISORD, V41, P826, DOI 10.1007/s10803-010-1103-y Magnee MJCM, 2009, NEUROPSYCHOLOGIA, V47, P1728, DOI 10.1016/j.neuropsychologia.2009.02.012 Magnee MJCM, 2008, J CHILD PSYCHOL PSYC, V49, P995, DOI 10.1111/j.1469-7610.2008.01902.x MCGURK H, 1976, NATURE, V264, P746, DOI 10.1038/264746a0 Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303 Mongillo EA, 2008, J AUTISM DEV DISORD, V38, P1349, DOI 10.1007/s10803-007-0521-y NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3 Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489 Russo N, 2010, AUTISM RES, V3, P253, DOI 10.1002/aur.152 SALDANA HM, 1993, PERCEPT PSYCHOPHYS, V54, P406, DOI 10.3758/BF03205276 Schneider TR, 2008, EXP PSYCHOL, V55, P121, DOI 10.1027/1618-3169.55.2.121 Smith EG, 2007, J CHILD PSYCHOL PSYC, V48, P813, DOI 10.1111/j.1469-7610.2007.01766.x Stein BE, 2010, EUR J NEUROSCI, V31, P1713, DOI 10.1111/j.1460-9568.2010.07206.x Taylor N, 2010, J AUTISM DEV DISORD, V40, P1403, DOI 10.1007/s10803-010-1000-4 Tremblay C, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000742 van der Smagt MJ, 2007, J AUTISM DEV DISORD, V37, P2014, DOI 10.1007/s10803-006-0346-0 Williams JHG, 2004, RES DEV DISABIL, V25, P559, DOI 10.1016/j.ridd.2004.01.008 NR 28 TC 9 Z9 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2011 VL 4 IS 5 BP 383 EP 388 DI 10.1002/aur.210 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 836XX UT WOS:000296153500007 PM 21882310 ER PT J AU Yerys, BE Pennington, BF AF Yerys, Benjamin E. Pennington, Bruce F. TI How do We Establish a Biological Marker for a Behaviorally Defined Disorder? Autism as a Test Case SO AUTISM RESEARCH LA English DT Editorial Material DE cognitive neuroscience; neuroimaging; diagnosis ID SPECTRUM DISORDERS; PATHOLOGY; DIAGNOSIS; BRAIN AB We discuss the recent push to develop support vector machines and other cluster analyses as a means for biological signatures as early screens for autism. These methods not only hold great promise but also require careful consideration prim to implementation. We outline three validity tests and potential methods for addressing them. Autism Res 2011,4:239-241. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. CR Anderson PJ, 2010, MOL GENET METAB, V99, pS3, DOI 10.1016/j.ymgme.2009.10.005 Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444 Bishop D, 2009, ANN NY ACAD SCI, V1156, P1, DOI 10.1111/j.1749-6632.2009.04419.x BISHOP DVM, 2010, DIFFERENCE P 0 05 SC Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010 Ecker C, 2010, NEUROIMAGE, V49, P44, DOI 10.1016/j.neuroimage.2009.08.024 Giedd JN, 1999, NAT NEUROSCI, V2, P861, DOI 10.1038/13158 HENEGHAN C, 2010, WHY AUTISM CANT BE D Lange N, 2010, AUTISM RES, V3, P350, DOI 10.1002/aur.162 Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934 Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X Oller DK, 2010, P NATL ACAD SCI USA, V107, P13354, DOI 10.1073/pnas.1003882107 Riley KP, 2002, ANN NEUROL, V51, P567, DOI 10.1002/ana.10161 Stevenson JL, 2010, J NEUROSCI, V30, P16763, DOI 10.1523/JNEUROSCI.4946-10.2010 NR 14 TC 3 Z9 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2011 VL 4 IS 4 BP 239 EP 241 DI 10.1002/aur.204 PG 3 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 813TM UT WOS:000294393100001 PM 21710504 ER PT J AU Rosenspire, A Yoo, W Menard, S Torres, AR AF Rosenspire, Allen Yoo, Wonsuk Menard, Sherri Torres, Anthony R. TI Autism Spectrum Disorders are Associated With an Elevated Autoantibody Response to Tissue Transglutaminase-2 SO AUTISM RESEARCH LA English DT Article DE immunology; anti-transglutaminase antibody; pediatrics ID CELIAC-DISEASE; NEURODEGENERATIVE DISEASES; POSSIBLE INVOLVEMENT; NERVOUS-SYSTEM; ANTIBODIES; SYMPTOMS; GENETICS; CHILDREN; ARTICLE; HLA-DR4 AB We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. Autism Res 2011,4:242-249. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Rosenspire, Allen; Menard, Sherri] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA. [Yoo, Wonsuk] Wayne State Univ, Sch Med, Dept Internal Med, Detroit, MI 48201 USA. [Torres, Anthony R.] Utah State Univ, Ctr Persons Disabil, Logan, UT 84322 USA. RP Rosenspire, A (reprint author), Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Room 221,Lande Med Res Bldg,550 E Canfield St, Detroit, MI 48201 USA. EM arosenspire@wayne.edu FU Cure Autism Now Foundation (which has merged with Autism Speaks); Autism Genetic Resource Exchange (AGRE); National Institute of Mental Health [1U24MH081810] FX Grant sponsors: Cure Autism Now Foundation (which has merged with Autism Speaks); Autism Genetic Resource Exchange (AGRE); National Institute of Mental Health; Grant number: 1U24MH081810. CR Alaedini A, 2005, ANN INTERN MED, V142, P289 Altevogt BM, 2008, PEDIATRICS, V121, P1225, DOI 10.1542/peds.2007-3000 Ashwood P, 2006, J LEUKOCYTE BIOL, V80, P1, DOI 10.1189/jlb.1205707 Ayensu Wellington K, 2004, Int J Environ Res Public Health, V1, P39, DOI 10.3390/ijerph2004010039 Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589 Black C, 2002, BRIT MED J, V325, P419, DOI 10.1136/bmj.325.7361.419 Blundell J, 2010, J NEUROSCI, V30, P2115, DOI 10.1523/JNEUROSCI.4517-09.2010 Boscolo S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009698 Bushara KO, 2005, GASTROENTEROLOGY, V128, pS92, DOI 10.1053/j.gastro.2005.02.018 Cabanlit M, 2007, ANN NY ACAD SCI, V1107, P92, DOI 10.1196/annals.1381.010 DANIELS WW, 1995, NEUROPSYCHOBIOLOGY, V32, P120, DOI 10.1159/000119223 De Vivo G, 2009, CURR MED CHEM, V16, P4767 De Vivo G, 2008, CNS NEUROL DISORD-DR, V7, P370, DOI 10.2174/187152708786441821 Diamond B, 2009, NAT REV IMMUNOL, V9, P449, DOI 10.1038/nri2529 Dieterich W, 1998, GASTROENTEROLOGY, V115, P1317, DOI 10.1016/S0016-5085(98)70007-1 Erickson CA, 2005, J AUTISM DEV DISORD, V35, P713, DOI 10.1007/s10803-005-0019-4 Esposito C, 2002, GUT, V51, P177, DOI 10.1136/gut.51.2.177 Fasano A, 2003, ARCH INTERN MED, V163, P286, DOI 10.1001/archinte.163.3.286 Festoff BW, 2001, INT REV CYTOL, V211, P153, DOI 10.1016/S0074-7696(01)11018-1 Gentile Vittorio, 2004, Current Drug Targets - CNS and Neurological Disorders, V3, P99, DOI 10.2174/1568007043482552 Hadjivassiliou M, 2008, ANN NEUROL, V64, P332, DOI 10.1002/ana.21450 HAND D, 1993, INT J DEV NEUROSCI, V11, P709, DOI 10.1016/0736-5748(93)90060-Q Heuer L, 2008, AUTISM RES, V1, P275, DOI 10.1002/aur.42 Johannesson M, 2006, CURR TOP MICROBIOL, V305, P259, DOI 10.1007/3-540-29714-6_13 Johnson WG, 2009, ARCH PEDIAT ADOL MED, V163, P542, DOI 10.1001/archpediatrics.2009.74 Karpuj M, 2004, AMINO ACIDS, V26, P373, DOI 10.1007/s00726-004-0082-8 Krause I, 2002, J AUTISM DEV DISORD, V32, P337, DOI 10.1023/A:1016391121003 Louka AS, 2003, TISSUE ANTIGENS, V61, P105 MACCIONI RB, 1986, MOL CELL BIOCHEM, V69, P161 Mahoney SA, 1996, BIOCHEM BIOPH RES CO, V224, P147, DOI 10.1006/bbrc.1996.0998 Mata S, 2006, ACTA NEUROL SCAND, V114, P54, DOI 10.1111/j.1600-0404.2006.00602.x Myrsky E, 2008, CLIN EXP IMMUNOL, V152, P111, DOI 10.1111/j.1365-2249.2008.03600.x National Institutes of Health, 2005, NIH PUBL, P1 Pavone L, 1997, BIOL PSYCHIAT, V42, P72, DOI 10.1016/S0006-3223(97)00267-9 Reveille JD, 2006, AUTOIMMUN REV, V5, P389, DOI 10.1016/j.autrev.2005.10.012 Sollid LM, 2000, ANNU REV IMMUNOL, V18, P53, DOI 10.1146/annurev.immunol.18.1.53 Sudhof TC, 2008, NATURE, V455, P903, DOI 10.1038/nature07456 Torres AR, 2002, HUM IMMUNOL, V63, P311, DOI 10.1016/S0198-8859(02)00374-9 Torres AR, 2001, FRONT BIOSCI, V6, pD936, DOI 10.2741/Torres Torres AR, 2006, HUM IMMUNOL, V67, P346, DOI 10.1016/j.humimm.2006.01.001 Valicenti-McDermott MD, 2008, PEDIATR NEUROL, V39, P392, DOI 10.1016/j.pediatrneurol.2008.07.019 Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315 Wakefield AJ, 2002, ALIMENT PHARM THER, V16, P663, DOI 10.1046/j.1365-2036.2002.01206.x Warren RP, 1996, J NEUROIMMUNOL, V67, P97 White JF, 2003, EXP BIOL MED, V228, P639 Wills S, 2009, BRAIN BEHAV IMMUN, V23, P64, DOI 10.1016/j.bbi.2008.07.007 Wills S, 2007, ANN NY ACAD SCI, V1107, P79, DOI 10.1196/annals.1381.009 Zhao X, 2007, P NATL ACAD SCI USA, V104, P12831, DOI 10.1073/pnas.0705803104 NR 48 TC 6 Z9 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2011 VL 4 IS 4 BP 242 EP 249 DI 10.1002/aur.194 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 813TM UT WOS:000294393100002 PM 21506289 ER PT J AU Tassone, F Qi, LH Zhang, WT Hansen, RL Pessah, IN Hertz-Picciotto, I AF Tassone, Flora Qi, Lihong Zhang, Wenting Hansen, Robin L. Pessah, Isaac N. Hertz-Picciotto, Irva TI MAOA, DBH, and SLC6A4 Variants in CHARGE: A Case-Control Study of Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE ASD; polymorphisms; SLC6A4; MAOA; DBH ID MONOAMINE-OXIDASE-A; OBSESSIVE-COMPULSIVE DISORDER; SEROTONIN REUPTAKE INHIBITORS; TRANSPORTER PROMOTER VARIANTS; BETA-HYDROXYLASE ACTIVITY; GENE POLYMORPHISMS; FUNCTIONAL POLYMORPHISM; SOMATOSENSORY CORTEX; BEHAVIORAL-DISORDERS; ANXIETY DISORDERS AB Genetic factors are established to contribute to the development of autism. We examined three loci, serotonin transporter (SLC6A4), dopamine beta-hydroxylase (DBH), and the variable number of tandem repeat promoter of the monoamine oxidase A (MAOA) for association with autism in participants from the Childhood Autism Risks from Genetics and the Environment (CHARGE) Study, the first large-scale population-based case-control investigation of both environmental and genetic contributions to autism risk. Among male children enrolled in the CHARGE study we tested associations between each of the three polymorphisms and autism (AU) (n = 119), or a combined group of autism and other autism spectrum disorders (AU+ASD, which includes an additional n = 53) as compared with typically developing controls (TD, n = 137). The case-control association analysis showed neither SLC6A4 nor DBH to be statistically significantly associated with AU or ASD. However, the male children carrying 4 tandem repeats in the promoter region of the MAOA gene showed a two-fold higher risk of AU (or AU+ASD) than those carrying allele 3, adjusted for confounders (OR = 2.02, 95% CI = 1.12, 3.65, P = 0.02 for AU vs. TD, and OR = 2.05, 95% CI = 1.19, 3.53, P = 0.01 for ASD vs. TD). In addition, children of mothers homozygous for the 4 tandem repeat allele showed at least a three-fold higher risk of AU (or AU+ASD) than those with mothers homozygous for allele 3 (OR = 3.07, 95% CI = 1.19, 7.91, P = 0.02 for AU vs. TD, and OR = 3.26, 95,6 CI = 1.35, 7.89, P = 0.009 for AU+ASD vs. TD). These results suggest a potential role of the functional MAOA promoter alleles in the male child, the mother, or both in ASD. Autism Res 2011,4:250-261. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Tassone, Flora; Zhang, Wenting] Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Davis, CA 95616 USA. [Tassone, Flora; Qi, Lihong; Hansen, Robin L.; Pessah, Isaac N.; Hertz-Picciotto, Irva] Univ Calif Davis, Med Ctr, MIND Inst, Davis, CA 95616 USA. [Qi, Lihong] Univ Calif Davis, Sch Med, Rowe Program Human Genet, Davis, CA 95616 USA. [Qi, Lihong; Hertz-Picciotto, Irva] Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA 95616 USA. [Hansen, Robin L.] Univ Calif Davis, Sch Med, Dept Pediat, Davis, CA 95616 USA. [Pessah, Isaac N.] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA. [Pessah, Isaac N.; Hertz-Picciotto, Irva] Univ Calif Davis, UC Davis Ctr Childrens Environm Hlth & Dis Preven, Davis, CA 95616 USA. RP Tassone, F (reprint author), Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, 1 Shields Ave, Davis, CA 95616 USA. EM ftassone@ucdavis.edu FU MIND Institute; Autism Speaks/Cure Autism Now; National Institute of Environmental Health Sciences [R01-ES015359, P01ES011269]; Environmental Protection Agency [R833292, R829388] FX Grant sponsors: MIND Institute Research and Gift funds (FT) and matching funds for the CHARGE Study; Autism Speaks/Cure Autism Now Environmental Innovator Award (INP); National Institute of Environmental Health Sciences; Grant numbers: R01-ES015359; P01ES011269; Grant sponsor: Environmental Protection Agency; Grant numbers: R833292; R829388. CR ANDERSON GM, 1987, J CHILD PSYCHOL PSYC, V28, P885, DOI 10.1111/j.1469-7610.1987.tb00677.x ANDERSON GM, 1990, ANN NY ACAD SCI, V600, P331, DOI 10.1111/j.1749-6632.1990.tb16893.x Anderson GM, 2002, MOL PSYCHIATR, V7, P831, DOI 10.1038/sj.mp.4001099 Anderson GM, 1990, ANN NY ACAD SCI, V600, P341 Anderson GM, 2002, J AM ACAD CHILD PSY, V41, P1513, DOI 10.1097/01.CHI.0000024874.60748.28 Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators, 2007, MMWR SURVEILL SUMM, V56, P12 BAILEY A, 1995, PSYCHOL MED, V25, P63 Bartlett CW, 2005, INT J DEV NEUROSCI, V23, P221, DOI 10.1016/j.ijdevneu.2004.10.004 Bill BR, 2009, CURR OPIN GENET DEV, V19, P271, DOI 10.1016/j.gde.2009.04.004 Buckholtz JW, 2008, TRENDS NEUROSCI, V31, P120, DOI 10.1016/j.tins.2007.12.006 Buxbaum Joseph D, 2009, Dialogues Clin Neurosci, V11, P35 Cases O, 1996, NEURON, V16, P297, DOI 10.1016/S0896-6273(00)80048-3 COHEN I, 2010, CLIN GENET, V79, P355 Cohen IL, 2003, CLIN GENET, V64, P190, DOI 10.1034/j.1399-0004.2003.00115.x Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008 Cook EH, 1997, MOL PSYCHIATR, V2, P247 Cook E H Jr, 1990, J Neuropsychiatry Clin Neurosci, V2, P268 Cubells JF, 2000, MOL PSYCHIATR, V5, P56, DOI 10.1038/sj.mp.4000657 Deckert J, 1999, HUM MOL GENET, V8, P621, DOI 10.1093/hmg/8.4.621 Denney RM, 1999, HUM GENET, V105, P542, DOI 10.1007/s004390051143 Devlin B, 2005, MOL PSYCHIATR, V10, P1110, DOI 10.1038/sj.mp.4001724 D'Souza UM, 2008, PROG BRAIN RES, V172, P73, DOI 10.1016/S0079-6123(08)00904-7 Filic V, 2005, J NEUROL SCI, V228, P149, DOI 10.1016/j.jns.2004.11.045 FOMBONNE E, 2003, PREVALENCE AUTISM, P87 Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896 Freitag CM, 2010, EUR CHILD ADOLES PSY, V19, P169, DOI 10.1007/s00787-009-0076-x Gaspar P, 2003, NAT REV NEUROSCI, V4, P1002, DOI 10.1038/nrn1256 Gillberg C., 2000, BIOL AUTISTIC SYNDRO GILMAN JT, 1995, ANN PHARMACOTHER, V29, P47 Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953 Goldberg WA, 2003, J AUTISM DEV DISORD, V33, P607, DOI 10.1023/B:JADD.0000005998.47370.ef GORDON CT, 1993, ARCH GEN PSYCHIAT, V50, P441 Guhathakurta S, 2006, BRAIN RES, V1092, P28, DOI 10.1016/j.brainres.2006.03.078 Hallett V, 2010, AM J PSYCHIAT, V167, P809, DOI 10.1176/appi.ajp.2009.09070990 Hansen RL, 2008, AMBUL PEDIATR, V8, P25, DOI 10.1016/j.ambp.2007.08.006 Heils A, 1996, J NEUROCHEM, V66, P2621 Hellings JA, 1996, J CLIN PSYCHIAT, V57, P333 Hertz-Picciotto I., 2011, AUTISM SPECTRUM DISO Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483 Hranilovic D, 2008, COLLEGIUM ANTROPOL, V32, P75 Jones MB, 2004, AM J MED GENET B, V126B, P58, DOI 10.1002/ajmg.b.20172 Klauck SM, 1997, HUM MOL GENET, V6, P2233, DOI 10.1093/hmg/6.13.2233 LAKE CR, 1977, ARCH GEN PSYCHIAT, V34, P553 LAMB JA, 2000, AUTISM RECENT MOL GE, P861 Lee SY, 2009, ALCOHOL CLIN EXP RES, V33, P985, DOI 10.1111/j.1530-0277.2009.00919.x Lesch KP, 1996, SCIENCE, V274, P1527, DOI 10.1126/science.274.5292.1527 Lichtenstein P, 2010, AM J PSYCHIAT, V167, P1357, DOI 10.1176/appi.ajp.2010.10020223 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x Maestrini E, 1999, AM J MED GENET, V88, P492, DOI 10.1002/(SICI)1096-8628(19991015)88:5<492::AID-AJMG11>3.0.CO;2-X Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 May ME, 2009, AJIDD-AM J INTELLECT, V114, P269, DOI 10.1352/1944-7558-114.4.269-273 McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P993 Muhle R., 2004, PEDIATRICS, V113, P472 Mullen E, 1995, MULLEN SCALES EARLY Nordquist N, 2010, UPSALA J MED SCI, V115, P2, DOI 10.3109/03009730903573246 Owley T, 2002, J CHILD ADOL PSYCHOP, V12, P165, DOI 10.1089/104454602760219207 Ozonoff S, 2010, J AM ACAD CHILD PSY, V49, P256, DOI 10.1016/j.jaac.2009.11.009 Persico AM, 2000, AM J MED GENET, V96, P123, DOI 10.1002/(SICI)1096-8628(20000207)96:1<123::AID-AJMG24>3.0.CO;2-N Pessah IN, 2008, CURR CLIN NEUROL, P409, DOI 10.1007/978-1-60327-489-0_19 Pigott TA, 1999, J CLIN PSYCHIAT, V60, P101 PIVEN J, 1991, J AUTISM DEV DISORD, V21, P51, DOI 10.1007/BF02206997 Ramoz N, 2006, BIOL PSYCHIAT, V60, P186, DOI 10.1016/j.biopsych.2006.01.009 RAO GV, 1993, MOL CELL BIOCHEM, V124, P107, DOI 10.1007/BF00929202 Ravindran LN, 2010, J CLIN PSYCHIAT, V71, P839, DOI 10.4088/JCP.10r06218blu RITVO ER, 1985, AM J PSYCHIAT, V142, P74 Robinson PD, 2001, AM J MED GENET, V100, P30, DOI 10.1002/ajmg.1187 Roohi J, 2009, J AUTISM DEV DISORD, V39, P67, DOI 10.1007/s10803-008-0600-8 Sabol SZ, 1998, HUM GENET, V103, P273, DOI 10.1007/s004390050816 Samochowiec J, 2004, PSYCHIAT RES, V128, P21, DOI 10.1016/j.psychres.2004.05.012 Shinnar S, 2001, PEDIATR NEUROL, V24, P183 Sparrow SS, 2005, VINELAND ADAPTIVE BE STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x Sweeney C, 2007, CANCER EPIDEM BIOMAR, V16, P142, DOI 10.1158/1055-9965.EPI-06-0706 Todorov C, 2000, CAN J PSYCHIAT, V45, P257 Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Wang TJ, 2007, PROG NEURO-PSYCHOPH, V31, P108, DOI 10.1016/j.pnpbp.2006.08.010 Wassink T H, 2000, Curr Psychiatry Rep, V2, P170, DOI 10.1007/s11920-000-0063-x Williams K, 2010, COCHRANE DB SYST REV, V8 Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49 Yirmiya N, 2002, AM J MED GENET, V114, P284, DOI 10.1002/ajmg.10189 Yirmiya N, 2001, AM J MED GENET, V105, P381, DOI 10.1002/ajmg.1365 Yoo HJ, 2009, NEUROSCI RES, V63, P172, DOI 10.1016/j.neures.2008.11.007 Zhang Z, 2011, NEUROSCIENCE, V174, P10, DOI 10.1016/j.neuroscience.2010.11.045 NR 85 TC 12 Z9 13 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2011 VL 4 IS 4 BP 250 EP 261 DI 10.1002/aur.196 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 813TM UT WOS:000294393100003 PM 21538940 ER PT J AU Barua, M Jenkins, EC Chen, WQ Kuizon, S Pullarkat, RK Junaid, MA AF Barua, Madhabi Jenkins, Edmund C. Chen, Wenqiang Kuizon, Salomon Pullarkat, Raju K. Junaid, Mohammed A. TI Glyoxalase I Polymorphism rs2736654 Causing the Ala111Glu Substitution Modulates Enzyme Activity-Implications for Autism SO AUTISM RESEARCH LA English DT Article DE autism; glyoxalase I; SNP; advanced glycation endproducts (AGEs); receptor for advanced glycation end products (RAGEs); methylglyoxal ID PEPSTATIN-INSENSITIVE PROTEINASE; NEURONAL CEROID-LIPOFUSCINOSIS; CULTURED CORTICAL-NEURONS; GLYCATION END-PRODUCTS; TRIOSEPHOSPHATE ISOMERASE; SPECTRUM DISORDERS; OXIDATIVE STRESS; AMINE OXIDASE; METHYLGLYOXAL; CELLS AB Autism is a pervasive, heterogeneous, neurodevelopmental disability characterized by impairments in verbal communications, reciprocal social interactions, and restricted repetitive stereotyped behaviors. Evidence suggests the involvement of multiple genetic factors in the etiology of autism, and extensive genome-wide association studies have revealed several candidate genes that bear single nucleotide polymorphisms (SNPs) in non-coding and coding regions. We have shown that a non-conservative, non-synonymous SNP in the glyoxalase I gene, GLOI, may be an autism susceptibility factor. The GLOI rs2736654 SNP is a C -> A change that causes an Ala111Glu change in the Glo1 enzyme. To identify the significance of the SNP, we have conducted functional assays for Glo1. We now present evidence that the presence of the A-allele at rs2736654 results in reduced enzyme activity. Glo1 activity is decreased in lymphoblastoid cells that are homozygous for the A allele. The Glu-isoform of Glo1 in these cells is hyperphosphorylated. Direct HPLC measurements of the glyoxalase I substrate, methylglyoxal (MG), show an increase in MG in these cells. Western blot analysis revealed elevated levels of the receptor for advanced glycation end products (RAGEs). We also show that MG is toxic to the developing neuronal cells. We suggest that accumulation of MG results in the formation of AGEs, which induce expression of the RAGE that during crucial neuronal development may be a factor in the pathology of autism. Autism Res 2011,4:262-270. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Barua, Madhabi; Jenkins, Edmund C.; Chen, Wenqiang; Kuizon, Salomon; Pullarkat, Raju K.; Junaid, Mohammed A.] New York State Inst Basic Res Dev Disabil, Dept Dev Biochem, New York, NY 10314 USA. RP Junaid, MA (reprint author), New York State Inst Basic Res Dev Disabil, Dept Dev Biochem, 1050 Forest Hill Rd, New York, NY 10314 USA. EM mohammed.junaid@omr.state.ny.us FU National Institutes of Health [NS40691]; New York State Office for People with Developmental Disabilities (formerly the New York State Office of Mental Retardation and Developmental Disabilities); National Alliance for Autism Research (NAAR) FX Grant sponsor: National Institutes of Health; Grant number: NS40691; Grant Sponsors: New York State Office for People with Developmental Disabilities (formerly the New York State Office of Mental Retardation and Developmental Disabilities); National Alliance for Autism Research (NAAR). Published online 12 April 2011 in Wiley Online Library (wileyonlinelibrary.com) CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Ahmed N, 2003, BBA-MOL BASIS DIS, V1639, P121, DOI 10.1016/j.bbadis.2003.08.002 Amicarelli F, 1998, MECH AGEING DEV, V100, P261, DOI 10.1016/S0047-6374(97)00148-6 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Blom N, 1999, J MOL BIOL, V294, P1351, DOI 10.1006/jmbi.1999.3310 Boso M, 2006, NEUROSCI LETT, V410, P169, DOI 10.1016/j.neulet.2006.08.092 Buxhoeveden DP, 2006, NEUROPATH APPL NEURO, V32, P483, DOI 10.1111/j.1365-2990.2006.00745.x Cameron AD, 1997, EMBO J, V16, P3386, DOI 10.1093/emboj/16.12.3386 Casanova MF, 2002, NEUROLOGY, V58, P428 Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133 Chaplen FWR, 1996, ANAL BIOCHEM, V238, P171, DOI 10.1006/abio.1996.0271 Chen WQ, 2009, NEUROCHEM RES, V34, P1658, DOI 10.1007/s11064-009-9959-y Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337 Di Loreto S, 2004, BRAIN RES, V1006, P157, DOI 10.1016/j.brainres.2004.01.066 Emanuele E, 2010, PROG NEURO-PSYCHOPH, V34, P681, DOI 10.1016/j.pnpbp.2010.03.020 Fujimoto M, 2008, NEUROSCI LETT, V438, P196, DOI 10.1016/j.neulet.2008.04.024 Gnerer JP, 2006, P NATL ACAD SCI USA, V103, P14987, DOI 10.1073/pnas.0606887103 Hovatta I, 2005, NATURE, V438, P662, DOI 10.1038/nature04250 Junaid MA, 2004, AM J MED GENET A, V131A, P11, DOI 10.1002/ajmg.a.30349 Junaid MA, 2000, J NEUROCHEM, V74, P287, DOI 10.1046/j.1471-4159.2000.0740287.x Junaid MA, 1999, CLIN CHIM ACTA, V281, P169, DOI 10.1016/S0301-2115(98)00333-9 KESTER MV, 1975, BIOCHIM BIOPHYS ACTA, V391, P212, DOI 10.1016/0005-2744(75)90168-0 Kikuchi S, 1999, J NEUROSCI RES, V57, P280, DOI 10.1002/(SICI)1097-4547(19990715)57:2<280::AID-JNR14>3.0.CO;2-U Kromer SA, 2005, J NEUROSCI, V25, P4375, DOI 10.1523/JNEUROSCI.0115-05.2005 Kuhla B, 2006, J NEUROSCI RES, V83, P1591, DOI 10.1002/jnr.20838 Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X Lowry Oliver H., 1951, J BIOL CHEM, V193, P265 LYLES GA, 1992, BIOCHEM PHARMACOL, V43, P1409, DOI 10.1016/0006-2952(92)90196-P MMWR, 2009, MMWR SURVEILL SUMM, V58, P1 Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069 Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472 PICKLES A, 1995, AM J HUM GENET, V57, P717 Politi P, 2006, NEUROSCI LETT, V396, P163, DOI 10.1016/j.neulet.2005.11.028 RANGANATHAN S, 1993, J BIOL CHEM, V268, P5661 RAY S, 1983, J BIOL CHEM, V258, P3461 Rehnstrom K, 2008, AM J MED GENET B, V147B, P124, DOI 10.1002/ajmg.b.30582 REICHARD GA, 1986, DIABETES, V35, P668, DOI 10.2337/diabetes.35.6.668 Ridderstrom M, 1998, J BIOL CHEM, V273, P21623, DOI 10.1074/jbc.273.34.21623 Risch N, 1999, AM J HUM GENET, V65, P493, DOI 10.1086/302497 Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d Rong LL, 2004, FASEB J, V18, P1812, DOI 10.1096/fj.04-1899com Sacco R, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-11 Sakamoto H, 2002, J BIOL CHEM, V277, P45770, DOI 10.1074/jbc.M207485200 Speer O, 2003, J BIOL CHEM, V278, P34757, DOI 10.1074/jbc.M301990200 Takeuchi M, 2000, J NEUROPATH EXP NEUR, V59, P1094 Tanaka N, 2000, J BIOL CHEM, V275, P25781, DOI 10.1074/jbc.M001235200 Thornalley PJ, 2003, BIOCHEM SOC T, V31, P1343 THORNALLEY PJ, 1991, HEREDITY, V67, P139, DOI 10.1038/hdy.1991.73 Thornalley PJ, 1996, GEN PHARMACOL, V27, P565, DOI 10.1016/0306-3623(95)02054-3 Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6 Van Herreweghe F, 2002, P NATL ACAD SCI USA, V99, P949, DOI 10.1073/pnas.012432399 van Kooten IAJ, 2008, BRAIN, V131, P987, DOI 10.1093/brain/awn033 WANG DZ, 1995, J BIOL CHEM, V270, P22924 Wu YY, 2008, PROG NEURO-PSYCHOPH, V32, P1740, DOI 10.1016/j.pnpbp.2008.07.019 NR 54 TC 17 Z9 18 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2011 VL 4 IS 4 BP 262 EP 270 DI 10.1002/aur.197 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 813TM UT WOS:000294393100004 PM 21491613 ER PT J AU Pellicano, E Stears, M AF Pellicano, Elizabeth Stears, Marc TI Bridging Autism, Science and Society: Moving Toward an Ethically Informed Approach to Autism Research SO AUTISM RESEARCH LA English DT Article DE autism; ethics; genetics; neuroscience; neurodiversity; activism ID SPECTRUM DISORDER; HEARING-LOSS; CHILDREN; DISABILITY; CLASSIFICATION; NEUROBIOLOGY; PREVALENCE; PREVENTION; DIAGNOSIS; PARENTS AB Recent developments in the science of autism have provoked widespread unease among autism activists. Drawing on the findings of a major international gathering of researchers, ethicists, and activists, this paper presents the first major analysis of the ethical questions arising from this unease. We outline the scientific developments that have provoked the most discomfort, analyze the response to these developments from within and without the autism community, and trace the current state of the ethical debate. Having done so, we contend that these ethical questions are unlikely to be resolved as they depend on fundamentally conflicting assumptions about the nature and desirability of neurocognitive difference. We conclude by arguing for a new range of democratic mechanisms that could enable the scientific community, autistics, and other concerned parties to respond collectively to such entrenched ethical disputes. Autism Res 2011,4:271-282. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Pellicano, Elizabeth] Inst Educ, Ctr Res Autism & Educ, Dept Psychol & Human Dev, London WC1H 0AA, England. [Pellicano, Elizabeth] Univ Western Australia, Sch Psychol, Crawley, Australia. [Stears, Marc] Univ Oxford, Dept Polit & Int Relat, Oxford, England. RP Pellicano, E (reprint author), Inst Educ, Ctr Res Autism & Educ, Dept Psychol & Human Dev, 25 Woburn Sq, London WC1H 0AA, England. EM l.pellicano@ioe.ac.uk FU Centre for Research in Autism and Education (CRAE) at the Institute of Education, London; Centre for Philosophy, Justice and Health at University College London; Autistica, the largest UK charity; Clothworkers' Foundation; Pears Foundation FX This paper was partly inspired by discussion at a one-day meeting held in London in June 2010, organized by Dr Liz Pellicano (Institute of Education, London) and Professor Jonathan Wolff (University College London), which aimed to initiate dialogue between scientists, practitioners and educators, representatives from charitable organizations and funding bodies, parents and carers of children with autism, and members of the autism community to identify and debate the real-world implications of the new and emerging scientific discoveries of autism. The meeting was generously funded by The Centre for Research in Autism and Education (CRAE) at the Institute of Education, London, The Centre for Philosophy, Justice and Health at University College London, and Autistica, the largest UK charity raising funds for medical research into autism. Research at CRAE is supported by The Clothworkers' Foundation and the Pears Foundation. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 *AM PSYCH ASS, 2010, 299 00 AUT DIS Auyeung B, 2009, BRIT J PSYCHOL, V100, P1, DOI 10.1348/000712608X311731 Bagatell N, 2010, ETHOS, V38, P33, DOI 10.1111/j.1548-1352.2009.01080.x BAGGS A, 2007, MY OWN LANGUAGE Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 BAKER J, 2008, AM J PUBLIC HEALTH, V9, P244 BARONCOHEN S, 2009, STUDYING AUTISM GENE BARONCOHEN S, 2009, GUARDIAN 0120 Baron-Cohen S, 2004, PRENATAL TESTOSTERON Baron-Cohen S, 2000, DEV PSYCHOPATHOL, V12, P489, DOI 10.1017/S0954579400003126 BEAUDET AL, 2010, NATURE, V446, P816 BEGLEY S, 2009, NEWSWEEK 0221 Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001 Bettelheim B., 1967, EMPTY FORTRESS INFAN BISHOP DVM, 2010, DIFFERENCE P 0 05 SC BOSELEY S, 2009, GUARDIAN 0112 BOVELL V, 2006, MAIL 0619 Charman T, 2004, MAPPING AUTISM RES I Collins HM, 2002, SOC STUD SCI, V32, P235, DOI 10.1177/0306312702032002003 DAWSON G, 2010, COMMUNICATION Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370 DAWSON M, 2004, MISBEHAVIOR BEHAV Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010 Elsabbagh M, 2010, TRENDS COGN SCI, V14, P81, DOI 10.1016/j.tics.2009.12.005 Epstein Steven, 1996, IMPURE SCI AIDS ACTI Fishkin J. S., 2009, PEOPLE SPEAK DELIBER FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8 Fung A., 2006, EMPOWERED PARTICIPAT Gastil J., 2005, DELIBERATIVE DEMOCRA GERNSBACHER MA, 2007, OBSERVER, V20, P13 Glover J., 2006, CHOOSING CHILDREN GE Goldstein DB, 2009, NEW ENGL J MED, V360, P1696, DOI 10.1056/NEJMp0806284 Grinker RR, 2010, ETHOS, V38, P172, DOI 10.1111/j.1548-1352.2009.01087.x Gross L, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000114 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 HENEGHAN C, 2010, WHY AUTISM CANT BE D, P12 Humphrey N, 2008, AUTISM, V12, P23, DOI 10.1177/1362361307085267 HUTCHISON T, 1995, ARCH DIS CHILD, V73, P91 INSET T, 2007, INT M AUT RES SEATTL Israel BA, 2005, ENVIRON HEALTH PERSP, V113, P1463, DOI 10.1289/ehp.7675 Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361 Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x JONES MB, 1988, J AUTISM DEV DISORD, V18, P31, DOI 10.1007/BF02211816 Jordan BR, 2010, J MED ETHICS, V36, P440, DOI 10.1136/jme.2009.031385 KALB C, 2010, NEWSWEEK 0329 Kaufman SR, 2010, ETHOS, V38, P8, DOI 10.1111/j.1548-1352.2009.01079.x Kiernan C., 1999, BRIT J LEARN DISABIL, V27, P43, DOI 10.1111/bld.1999.27.issue-2 King D., 1999, NAME LIBERALISM ILLI Knapp M, 2009, AUTISM, V13, P317, DOI 10.1177/1362361309104246 Kogan M. D., 2007, PEDIATRICS, V124, P1395, DOI DOI 10.1542/PEDS.2009-1522 Ladd P, 2003, SEARCH DEAFHOOD Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3 Lintas C, 2009, J MED GENET, V46, P1, DOI 10.1136/jmg.2008.060871 McGrath Robert J, 2009, Pediatrics, V124 Suppl 4, pS443, DOI 10.1542/peds.2009-1255Q McMahon WM, 2006, AM J MED GENET C, V142C, P52, DOI 10.1002/ajmg.c.30082 *MED RES COUNC, 2002, REV AUT RES EP CAUS Medical Research Council, 2010, AUT AD DIAGN QUICK N Medical Research Council, 2010, REV MENT HLTH RES RE MILLER DT, 2010, AM J HUM GENET, V14, P749 Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945 MOORE C, 2010, GUARDIAN 0610 Moore K, 2008, PRINC STUD CULT, P1 Moser Charlotte A., 2009, PEDIATRICS, V123, P164 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 National Institute of Mental Health, 2008, NAT I MENT HLTH STRA Nussbaum Martha, 2006, FRONTIERS JUSTICE DI Oliver M., 1990, POLITICS DISABLEMENT Orsini M., 2010, CRITICAL POLICY STUD, V4, P38, DOI DOI 10.1080/19460171003714989 Pellicano E, 2006, DEV PSYCHOPATHOL, V18, P77, DOI 10.1017/S0954579406060056 Pierson P, 2000, AM POLIT SCI REV, V94, P251, DOI 10.2307/2586011 Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613 Porter J, 2006, J RES SPECIAL ED NEE, V6, P11, DOI 10.1111/j.1471-3802.2006.00055.x Prince DE, 2010, ETHOS, V38, P56, DOI 10.1111/j.1548-1352.2009.01081.x Racine E, 2005, NAT REV NEUROSCI, V6, P159, DOI 10.1038/nrn1539 Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x RUDACILLE D, 2010, DIAGNOSTIC SCANS AUT Rutter M., 1978, AUTISM REAPPRAISAL C Sandel M., 2007, CASE PERFECTION ETHI Schalock R. L., 2010, INTELLECTUAL DISABIL, V11th Selkirk CG, 2009, J GENET COUNS, V18, P507, DOI 10.1007/s10897-009-9233-0 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x Shapiro J., 1994, NO PITY PEOPLE DISAB SHEN Y, 2010, PEDIATRICS, V125, P17 SHUTE N, 2010, SCI AM 1007 Silverman C, 2007, ARCH PEDIAT ADOL MED, V161, P392, DOI 10.1001/archpedi.161.4.392 Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f Simonoff E, 1998, J AUTISM DEV DISORD, V28, P447, DOI 10.1023/A:1026060623511 SINCLAIR J, 2010, WHY DISLIKE PERSON F Sinclair J., 1993, OUR VOICE, V1 Singer Judy, 1999, DISABILITY DISCOURSE, V1999, P59 Singh I, 2009, NATURE, V460, P202, DOI 10.1038/460202a Singh J, 2009, J AUTISM DEV DISORD, V39, P788, DOI 10.1007/s10803-008-0685-0 Stern SJ, 2002, J MED GENET, V39, P449, DOI 10.1136/jmg.39.6.449 Tabor HK, 2007, GENET MED, V9, P626, DOI 10.1097/GIM.0b013e3181485688 Tarini BA, 2009, PEDIATRICS, V124, pE432, DOI 10.1542/peds.2008-2389 Townson L., 2004, BRIT J LEARN DISABIL, V32, P72, DOI 10.1111/j.1468-3156.2004.00282.x WELLCOME T, 2010, WELLCOME TRUST STRAT WILLIAMS B, 2002, TRUTH TRUTHFULNESS A Williams D., 1994, SOMEBODY SOMEWHERE B Withrow KA, 2009, AM J MED GENET A, V149A, P1159, DOI 10.1002/ajmg.a.32800 Wolff J, 2009, METAPHILOSOPHY, V40, P402 WRIGHT S, MESSAGE SUZANNE BOB NR 103 TC 19 Z9 19 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2011 VL 4 IS 4 BP 271 EP 282 DI 10.1002/aur.201 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 813TM UT WOS:000294393100005 PM 21567986 ER PT J AU Farran, EK Brosnan, MJ AF Farran, Emily K. Brosnan, Mark J. TI Perceptual Grouping Abilities in Individuals With Autism Spectrum Disorder; Exploring Patterns of Ability in Relation to Grouping Type and Levels of Development SO AUTISM RESEARCH LA English DT Article ID HIGH-FUNCTIONING AUTISM; HUMAN VISUAL-CORTEX; WILLIAMS-SYNDROME; ASPERGER-SYNDROME; ATTENTIONAL MODULATION; CHILDREN; PERFORMANCE; ORGANIZATION; PRECEDENCE; DEFICIT AB This study further investigates findings of impairment in Gestalt, but not global processing in Autism Spectrum Disorder (ASD) [Brosnan, Scott, Fox, & Pye, 2004]. Nineteen males with ASD and nineteen typically developing (TD) males matched by nonverbal ability, took part in five Gestalt perceptual grouping tasks. Results showed that performance differed according to grouping type. The ASD group showed typical performance for grouping by proximity and by alignment, impairment on low difficulty trials for orientation and luminance similarity, and general impairment for grouping by shape similarity. Group differences were also observed developmentally; for the ASD group, with the exception of grouping by shape similarity, perceptual grouping performance was poorer at lower than higher levels of nonverbal ability. In contrast, no developmental progression was observed in the TD controls. Autism Res 2011,4:283-292. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Farran, Emily K.] Univ London, Inst Educ, Dept Psychol & Human Dev, London WC1H 0AA, England. [Brosnan, Mark J.] Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England. RP Farran, EK (reprint author), Univ London, Inst Educ, Dept Psychol & Human Dev, 25 Woburn Sq, London WC1H 0AA, England. EM E.Farran@ioe.ac.uk RI Farran, Emily/F-6382-2010 CR Annaz D, 2009, J EXP CHILD PSYCHOL, V102, P456, DOI 10.1016/j.jecp.2008.11.005 Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434 Bolte S, 2007, J AUTISM DEV DISORD, V37, P1493, DOI 10.1007/s10803-006-0231-x BONNEL A, NEUROPSYCHOLOGIA, V48, P2465 Booth R, 2003, PHILOS T ROY SOC B, V358, P387, DOI 10.1098/rstb.2002.1204 Bott L, 2006, Q J EXP PSYCHOL, V59, P1237, DOI 10.1080/02724980543000196 Brosnan MJ, 2004, J CHILD PSYCHOL PSYC, V45, P459, DOI 10.1111/j.1469-7610.2004.00237.x Deruelle C, 2004, J AUTISM DEV DISORD, V34, P199, DOI 10.1023/B:JADD.0000022610.09668.4c Deruelle C, 2006, INT J PSYCHOL, V41, P97, DOI 10.1080/00207590500184610 EDGIN JO, 2005, J AUTISM DEV DISORD, V19, P1 Falter CM, 2010, AUTISM RES, V3, P128, DOI 10.1002/aur.134 Farran EK, 2005, NEUROPSYCHOLOGIA, V43, P815, DOI 10.1016/j.neuropsychologia.2004.09.001 Farran EK, 2003, DEV NEUROPSYCHOL, V23, P173, DOI 10.1207/S15326942DN231&2_8 FARRAN EK, 2008, EUROPEAN J DEV SCI, V2, P353 Farroni T, 2000, PERCEPTION, V29, P355 Frith U., 1989, AUTISM EXPLAINING EN Han SH, 2005, HUM BRAIN MAPP, V26, P199, DOI 10.1002/hbm.20157 Han SH, 2005, HUM BRAIN MAPP, V25, P424, DOI 10.1002/hbm.20119 Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2 Jarrold C, 2005, DEVELOPMENTAL SCI, V8, P344, DOI 10.1111/j.1467-7687.2005.00422.x Jarrold C, 2004, J AUTISM DEV DISORD, V34, P81, DOI 10.1023/B:JADD.0000018078.82542.ab Joliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI DOI 10.1111/J.1469-7610.1997.TB01539.X Karmiloff-Smith A, 2009, DEV PSYCHOL, V45, P56, DOI 10.1037/a0014506 Leekam SR, 1998, J CHILD PSYCHOL PSYC, V39, P951, DOI 10.1017/S0021963098003035 Mottron L, 2003, J CHILD PSYCHOL PSYC, V44, P904, DOI 10.1111/1469-7610.00174 Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P743, DOI 10.1017/S0021963098003795 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 MOTTRON L, 1993, BRAIN COGNITION, V23, P279, DOI 10.1006/brcg.1993.1060 Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P203, DOI 10.1017/S0021963098003333 NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3 Penn HE, 2006, CHILD NEUROPSYCHOL, V12, P57, DOI 10.1080/09297040500253546 Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613 Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489 POMERANTZ JR, 1983, J EXPT PSYCHOL GEN, V112, P511 Quinn PC, 2005, PSYCHOL SCI, V16, P511, DOI 10.1111/j.0956-7976.2005.01567.x Riby DM, 2008, J NEUROPSYCHOL, V2, P47, DOI 10.1348/174866407X255690 Rondan C., 2004, J COGN BEHAV PSYCHOT, V4, P149 Rondan C, 2007, RES DEV DISABIL, V28, P197, DOI 10.1016/j.ridd.2006.02.007 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x Stroganova TA, 2007, NEUROREPORT, V18, P931, DOI 10.1097/WNR.0b013e32811e151b THOMAS MSC, 2009, J SPEECH LANG HEAR R, V52, P258 Wechsler D, 1981, WECHSLER ADULT INTEL Wechsler D, 1999, WECHSLER ABBREVIATED Witkin H. F., 1971, CHILDRENS EMBEDDED F NR 45 TC 7 Z9 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2011 VL 4 IS 4 BP 283 EP 292 DI 10.1002/aur.202 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 813TM UT WOS:000294393100006 PM 21608137 ER PT J AU Allen-Brady, K Cai, GQ Cannon, D Robison, R McMahon, WM Coon, H Buxbaum, JD AF Allen-Brady, Kristina Cai, Guiqing Cannon, Dale Robison, Reid McMahon, William M. Coon, Hilary Buxbaum, Joseph D. TI No Evidence for IL1RAPL1 Involvement in Selected High-Risk Autism Pedigrees from the AGRE Data Set SO AUTISM RESEARCH LA English DT Article DE behavioral analysis of animal models; developmental neurobiology; sex differences; testosterone; androgen receptor ID MENTAL-RETARDATION; ARX GENE; MUTATIONS; FAMILIES AB Finding predisposition genes for Autism Spectrum Disorder (ASD) has proven challenging, and new methods are needed to aid the process. Using pedigree structure as a strategy to identify ASD predisposition genes, we previously performed a genome-wide linkage scan of 86 selected families from the Autism Resource Exchange (AGRE) that appeared to inherit ASD in a dominant manner. We identified a suggestive linkage peak on chromosome Xp22.11-p21.2 that encompasses the IL1RAPL1 gene, a strong candidate gene for ASD. In this follow-up study, we sequenced the coding regions of the IL1RAPL1 gene in 14 male cases representing one case from each pedigree that showed at least nominal linkage evidence on per pedigree basis to the chromosome X region. We observed no deleterious mutations or deletions in the IL1RAPL1 gene in these 14 ASD cases. A SNP was identified in exon 2 in five cases and a variant of unknown significance was identified in intron 6 in a single case. In conclusion, coding changes of the IL1RAPL1 gene do not appear to be associated with ASD in selected AGRE families with linkage evidence to the chromosome Xp22.11-p21.2 region. Autism Res 201,1,4:293-296. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Allen-Brady, Kristina] Univ Utah, Dept Psychiat, Div Genet Epidemiol, Utah ASD Res Project, Salt Lake City, UT 84108 USA. [Cai, Guiqing; Buxbaum, Joseph D.] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY USA. [Cai, Guiqing; Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA. [McMahon, William M.; Coon, Hilary] Univ Utah, Inst Brain, Salt Lake City, UT 84108 USA. RP Allen-Brady, K (reprint author), Univ Utah, Dept Psychiat, Div Genet Epidemiol, Utah ASD Res Project, 391 Chipeta Way,Suite D, Salt Lake City, UT 84108 USA. EM kristina.allen@utah.edu FU National Institutes of Health [R01 MH069359]; Seaver Foundation, National Institute of Mental Health [1U24MH081810] FX Grant sponsor: National Institutes of Health; Grant number: R01 MH069359; Grant sponsor: Seaver Foundation, National Institute of Mental Health; Grant number: 1U24MH081810. CR Allen-Brady K, 2010, AUTISM RES, V3, P47, DOI 10.1002/aur.119 BHAT SS, 2001, CLIN GENET, V73, P94 Chaste P, 2007, AM J MED GENET B, V144B, P228, DOI 10.1002/ajmg.b.30440 Geschwind DH, 2001, AM J HUM GENET, V69, P463, DOI 10.1086/321292 LANDER E, 1995, NAT GENET, V11, P241, DOI 10.1038/ng1195-241 PITON A, 2001, HUM MOL GENET, V17, P3965 Stromme P, 2002, NAT GENET, V30, P441, DOI 10.1038/ng862 Suri M, 2005, DEV MED CHILD NEUROL, V47, P133, DOI 10.1017/S001216220500023X Turner G, 2002, AM J MED GENET, V112, P405, DOI 10.1002/ajmg.10714 Zhao X, 2007, P NATL ACAD SCI USA, V104, P12831, DOI 10.1073/pnas.0705803104 NR 10 TC 0 Z9 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2011 VL 4 IS 4 BP 293 EP 296 DI 10.1002/aur.195 PG 4 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 813TM UT WOS:000294393100007 PM 21491612 ER PT J AU Damiano, C Churches, O Ring, H Baron-Cohen, S AF Damiano, Cara Churches, Owen Ring, Howard Baron-Cohen, Simon TI The Development of Perceptual Expertise for Faces and Objects in Autism Spectrum Conditions SO AUTISM RESEARCH LA English DT Article DE face processing; object processing; autism spectrum conditions; inversion effect; perceptual expertise; configural processing; local processing ID FUNCTIONING AUTISM; ASPERGER-SYNDROME; RECOGNITION; INVERSION; DEFICIT; ADULTS; EYE AB Previous research indicates that individuals with autism spectrum conditions (ASC) do not develop face expertise to the same extent as typical individuals. Yet it remains unclear whether this atypicality is specific to faces or related to more pervasive perceptual or cognitive deficits involved in the actual process of gaining expertise. To address this question, we examined the extent to which adults with ASC were capable of developing expertise with non-face objects. To become experts, all participants completed a 2-week training program with novel objects, known as Greebles. Level of expertise was assessed throughout training by measuring the ability to identify Greebles on an individual level. The perceptual strategies acquired as a result of expertise were measured through an inversion effect task completed before and after training, in which performance with upright Greebles and faces was compared to performance with inverted Greebles and faces. After expertise training, it was found that individuals in both the ASC and the typical group successfully achieved expertise and showed an enhanced Greeble inversion effect as a result of training. The development of an inversion effect with Greebles suggests that individuals with ASC may employ the same processing strategies as the typical group. Although exploratory, these findings have implications for understanding the nature of the face processing deficit in ASC as well as offering potential insights into face processing interventions for individuals with ASC. Autism Res 2011,4:297-301. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Damiano, Cara] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA. [Damiano, Cara; Churches, Owen; Ring, Howard; Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 8AH, England. [Ring, Howard] Univ Cambridge, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge CB2 8AH, England. [Churches, Owen] Univ S Australia, Adelaide, SA 5001, Australia. RP Damiano, C (reprint author), Univ N Carolina, Dept Psychol, 247 Davie Hall, Chapel Hill, NC 27599 USA. EM cdamiano@email.unc.edu; sb205@cam.ac.uk FU MRC (UK) FX Grant sponsor: MRC (UK). CR American Psychiatric Association [APA], 1994, DSM 4 DIAGN STAT MAN Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Fallshore M, 2003, PERCEPT MOTOR SKILL, V96, P236, DOI 10.2466/PMS.96.1.236-244 Freire A, 2000, PERCEPTION, V29, P159, DOI 10.1068/p3012 Gauthier I, 1997, VISION RES, V37, P1673, DOI 10.1016/S0042-6989(96)00286-6 Gauthier I, 2000, NAT NEUROSCI, V3, P191, DOI 10.1038/72140 Gauthier I, 1998, VISION RES, V38, P2401, DOI 10.1016/S0042-6989(97)00442-2 Golan O, 2006, DEV PSYCHOPATHOL, V18, P591, DOI 10.1017/S0954579406060305 Grelotti DJ, 2002, DEV PSYCHOBIOL, V40, P213, DOI 10.1002/dev.10028 HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441 Jenkins J, 2003, PERCEPTION, V32, P1181, DOI 10.1068/p3398 Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Lahaie A, 2006, NEUROPSYCHOLOGY, V20, P30, DOI 10.1037/0894-4105.20.1.30 LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x Maurer D, 2002, TRENDS COGN SCI, V6, P255, DOI 10.1016/S1364-6613(02)01903-4 McKelvie SJ, 1995, CAN J EXP PSYCHOL, V49, P437, DOI 10.1037/1196-1961.49.4.437 Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613 RATCLIFF R, 1993, PSYCHOL BULL, V114, P510, DOI 10.1037/0033-2909.114.3.510 Rosenblum LD, 2000, J EXP PSYCHOL HUMAN, V26, P806, DOI 10.1037//0096-1523.26.2.806 Rossion B, 2002, PSYCHOL SCI, V13, P250, DOI 10.1111/1467-9280.00446 TANAKA JW, 1991, COGNITIVE PSYCHOL, V23, P457, DOI 10.1016/0010-0285(91)90016-H Teunisse JP, 2003, BRAIN COGNITION, V52, P285, DOI 10.1016/S0278-2626(03)00042-3 Troje NF, 1996, VISION RES, V36, P1761, DOI 10.1016/0042-6989(95)00230-8 Wechsler D, 1999, WECHSLER ABBREVIATED NR 24 TC 1 Z9 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2011 VL 4 IS 4 BP 297 EP 301 DI 10.1002/aur.205 PG 5 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 813TM UT WOS:000294393100008 PM 21710603 ER PT J AU Wintle, RF Lionel, AC Hu, PZ Ginsberg, SD Pinto, D Thiruvahindrapduram, B Wei, J Marshall, CR Pickett, J Cook, EH Scherer, SW AF Wintle, Richard F. Lionel, Anath C. Hu, Pingzhao Ginsberg, Stephen D. Pinto, Dalila Thiruvahindrapduram, Bhooma Wei, John Marshall, Christian R. Pickett, Jane Cook, Edwin H. Scherer, Stephen W. TI A Genotype Resource for Postmortem Brain Samples From the Autism Tissue Program (vol 4, pg 89, 2011) SO AUTISM RESEARCH LA English DT Correction CR Wintle RF, 2011, AUTISM RES, V4, P89, DOI 10.1002/aur.173 NR 1 TC 0 Z9 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2011 VL 4 IS 4 BP 314 EP 314 DI 10.1002/aur.211 PG 1 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 813TM UT WOS:000294393100009 ER PT J AU Pfaff, DW Rapin, I Goldman, S AF Pfaff, Donald W. Rapin, Isabelle Goldman, Sylvie TI Male Predominance in Autism: Neuroendocrine Influences on Arousal and Social Anxiety SO AUTISM RESEARCH LA English DT Review DE behavioral analysis of animal models; developmental neurobiology; sex differences; testosterone; androgen receptor ID PERVASIVE DEVELOPMENTAL DISORDERS; INDUCED NORADRENERGIC ACTIVATION; RIBONUCLEIC-ACID EXPRESSION; NEONATAL AMYGDALA LESIONS; ESTROGEN-RECEPTOR-ALPHA; PLASMA OXYTOCIN LEVELS; BASOLATERAL AMYGDALA; SEROTONIN TRANSPORTER; SPECTRUM DISORDERS; FETAL TESTOSTERONE AB We offer a neurobiologic theory based on animal work that helps account for the conspicuous male predominance in autism spectrum disorders (ASD). In young male animals, testosterone (TST) binds to androgen receptors (AR) in brainstem neurons responsible for enhancing brain arousal. As a consequence, arousal-related neurotransmitters bombard the amygdala hypersensitized by TST acting though AR. Arousal-related inputs are known to prime amygdaloid mechanisms for fear and anxiety, with resultant social avoidance. We hypothesize that similar mechanisms contribute to autism's male predominance and to its defining impaired social skills. The theory rests on two key interacting factors: the molecular effects of TST in genetically vulnerable boys in combination with environmental stresses they experienced in utero, neonatally, or during the first years. We postulate that higher TST levels and, therefore, higher amounts of arousal-related inputs to the amygdala sensitize these genetically vulnerable male infants to very early stresses. In sharp contrast to boys, girls not only do not have high levels of TST-facilitated arousal-causing inputs to the amygdala but they also enjoy the protection afforded by estrogenic hormones, oxytocin, and the oxytocin receptor. This theory suggests that novel technologies applied to the molecular endocrinology of TST's actions through AR will offer new avenues of enquiry into ASD. Since the high male preponderance in autism is important yet understudied, we offer our theory, which is based on detailed neurobehavioral research with animals, to stimulate basic and clinical research in animals and humans and hopefully help develop novel more effective medical treatments for autism. Autism Res 2011,4:163-176. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Goldman, Sylvie] Albert Einstein Coll Med, Kennedy Ctr, Dept Pediat, Bronx, NY 10461 USA. [Pfaff, Donald W.] Rockefeller Univ, New York, NY 10021 USA. [Rapin, Isabelle; Goldman, Sylvie] Yeshiva Univ Albert Einstein Coll Med, Saul R Korey Dept Neurol, Bronx, NY 10461 USA. [Rapin, Isabelle; Goldman, Sylvie] Rose F Kennedy Ctr Res Mental Retardat & Human De, Bronx, NY USA. RP Goldman, S (reprint author), Albert Einstein Coll Med, Kennedy Ctr, Dept Pediat, Room 807,1300 Morris Pk Ave, Bronx, NY 10461 USA. EM sylviegold@aol.com FU NIH [MH-38273, HD-05751]; U.S. Department of Health and Human Services-Maternal and Child Health Bureau (MCHB) Leadership Education in Neurodevelopmental Disabilities (LEND) [T73MC00027] FX Grant sponsor: NIH; Grant numbers: MH-38273; HD-05751; Grant sponsor: U.S. Department of Health and Human Services-Maternal and Child Health Bureau (MCHB) Leadership Education in Neurodevelopmental Disabilities (LEND); Grant number: T73MC00027. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Adolphs R, 2005, NATURE, V433, P68, DOI 10.1038/nature03086 AKAISHI T, 1985, BRAIN RES, V335, P302, DOI 10.1016/0006-8993(85)90481-0 Alleva E, 2001, PHYSIOL BEHAV, V73, P313, DOI 10.1016/S0031-9384(01)00498-X Amaral DG, 2003, GENES BRAIN BEHAV, V2, P295, DOI 10.1034/j.1601-183X.2003.00043.x American Psychiatric Association, 2000, DIAGN STAT MAN MENT Amiet C, 2008, BIOL PSYCHIAT, V64, P577, DOI 10.1016/j.biopsych.2008.04.030 Andari E, 2010, P NATL ACAD SCI USA, V107, P4389, DOI 10.1073/pnas.0910249107 Anderson GM, 2002, MOL PSYCHIATR, V7, P831, DOI 10.1038/sj.mp.4001099 Anderson GM, 2008, AUTISM RES, V1, P18, DOI 10.1002/aur.2 ANDERSON PK, 1965, SCIENCE, V148, P1753, DOI 10.1126/science.148.3678.1753 Anello A, 2009, J AUTISM DEV DISORD, V39, P1487, DOI 10.1007/s10803-009-0755-y Auyeung B, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-11 Auyeung B, 2009, PSYCHOL SCI, V20, P144, DOI 10.1111/j.1467-9280.2009.02279.x Auyeung B, 2009, BRIT J PSYCHOL, V100, P1, DOI 10.1348/000712608X311731 Aylward EH, 1999, NEUROLOGY, V53, P2145 Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455 Baron-Cohen S, 2009, BRIT J PSYCHOL, V100, P39, DOI 10.1348/000712608X394271 Baron-Cohen Simon, 2005, Cogn Neuropsychiatry, V10, P77, DOI 10.1080/13546800344000336 Baron-Cohen S, 2005, ANNU REV NEUROSCI, V28, P109, DOI 10.1146/annurev.neuro.27.070203.144137 Bartels A, 2004, NEUROIMAGE, V21, P1155, DOI 10.1016/j.neuroimage.2003.11.003 Bauman MD, 2004, J COGNITIVE NEUROSCI, V16, P1388, DOI 10.1162/0898929042304741 Bauman MD, 2005, NEUROSCIENCE, V136, P193, DOI 10.1016/j.neuroscience.2005.07.040 Bergman K, 2010, HORM BEHAV, V57, P306, DOI 10.1016/j.yhbeh.2009.12.012 Bilder D, 2009, PEDIATRICS, V123, P1293, DOI 10.1542/peds.2008-0927 Bosch OJ, 2005, J NEUROSCI, V25, P6807, DOI 10.1523/JNEUROSCI.1342-05.2005 Brazelton T. B., 1995, NEONATAL BEHAV ASSES Choleris E, 2009, FRONT NEUROENDOCRIN, V30, P442, DOI 10.1016/j.yfrne.2009.05.003 Choleris E, 2006, GENES BRAIN BEHAV, V5, P528, DOI 10.1111/j.1601-183X.2006.00203.x Choleris E, 2003, P NATL ACAD SCI USA, V100, P6192, DOI 10.1073/pnas.0631699100 Cook EH, 1997, MOL PSYCHIATR, V2, P247 Corbett BA, 2009, AUTISM RES, V2, P39, DOI 10.1002/aur.64 Cushing BS, 2000, HORM BEHAV, V37, P49, DOI 10.1006/hbeh.1999.1558 Davis EP, 2010, J CHILD PSYCHOL PSYC, V52, P119, DOI DOI 10.1111/J.1469-7610.2010.02314.X Davis EP, 2010, CHILD DEV, V81, P131, DOI 10.1111/j.1467-8624.2009.01385.x DERRYBERRY D, 1988, J PERS SOC PSYCHOL, V55, P958, DOI 10.1037/0022-3514.55.6.958 Dodds L, 2011, J AUTISM DEV DISORD, V41, P891, DOI 10.1007/s10803-010-1114-8 Durkin MS, 2008, AM J EPIDEMIOL, V168, P1268, DOI 10.1093/aje/kwn250 Elands J, 1988, J Chem Neuroanat, V1, P293 Etkin A, 2007, AM J PSYCHIAT, V164, P1476, DOI 10.1176/appi.ajp.2007.07030504 Feldman R, 2007, PSYCHOL SCI, V18, P965, DOI 10.1111/j.1467-9280.2007.02010.x Ferguson JN, 2002, FRONT NEUROENDOCRIN, V23, P200, DOI 10.1006/frne.2002.0229 Field T, 2006, INFANT BEHAV DEV, V29, P445, DOI 10.1016/j.infbeh.2006.03.003 Fombonne E, 2008, ARCH GEN PSYCHIAT, V65, P15, DOI 10.1001/archgenpsychiatry.2007.2 Fombonne E, 2007, CA CH AD PS, P33, DOI 10.1017/CBO9780511544446.003 Fox JK, 2010, J ADOLESCENCE, V33, P43, DOI 10.1016/j.adolescence.2009.05.009 Furmark T, 2004, NEUROSCI LETT, V362, P189, DOI 10.1016/j.neulet.2004.02.070 Gardener H, 2009, BRIT J PSYCHIAT, V195, P7, DOI 10.1192/bjp.bp.108.051672 GILMARTIN BG, 1987, SHYNESS LOVE CAUSES Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618 Glover V, 2009, PSYCHONEUROENDOCRINO, V34, P430, DOI 10.1016/j.psyneuen.2008.10.005 Green JJ, 2010, NEUROTHERAPEUTICS, V7, P250, DOI 10.1016/j.nurt.2010.05.006 Green LA, 2001, BIOL PSYCHIAT, V50, P609, DOI 10.1016/S0006-3223(01)01139-8 Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62 Guastella AJ, 2008, BIOL PSYCHIAT, V64, P256, DOI 10.1016/j.biopsych.2008.02.008 Gunnar M.R, 1989, NEW DIR CHILD ADOLES, V45, P3 Hamson DK, 2004, NEUROSCIENCE, V127, P797, DOI 10.1016/j.neuroscience.2004.06.006 Hariri AR, 2002, NEUROIMAGE, V17, P317, DOI 10.1006/nimg.2002.1179 Hariri AR, 2002, SCIENCE, V297, P400, DOI 10.1126/science.1071829 Hartley SL, 2009, J AUTISM DEV DISORD, V39, P1715, DOI 10.1007/s10803-009-0810-8 Heinz A, 2005, NAT NEUROSCI, V8, P20, DOI 10.1038/nn1366 Hofmann SG, 2007, J ANXIETY DISORD, V21, P944, DOI 10.1016/j.janxdis.2006.12.003 Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021 James WH, 2008, DEV MED CHILD NEUROL, V50, P15, DOI [10.1111/j.1469-8749.2007.02001.x, 10.1111/j.1469-8749.2007.0200.x] Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Juranek J, 2006, J CHILD NEUROL, V21, P1051, DOI 10.2310/7010.2006.00237 Jyonouchi H, 2008, J NEUROINFLAMM, V5, DOI 10.1186/1742-2094-5-52 Kalin N. H., 2004, J NEUROSCI, V24, P5506 Kanner L, 1943, NERV CHILD, V2, P217 Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004 Kinney DK, 2008, J AUTISM DEV DISORD, V38, P481, DOI 10.1007/s10803-007-0414-0 Kirsch P, 2005, J NEUROSCI, V25, P11489, DOI 10.1523/JNEUROSCI.3984-05.2005 Knickmeyer R, 2005, J CHILD PSYCHOL PSYC, V46, P198, DOI 10.1111/j.1469-7610.2004.00349.x KollackWalker S, 1997, J NEUROSCI, V17, P8842 KOW LM, 1991, NEUROENDOCRINOLOGY, V54, P526, DOI 10.1159/000125948 KURITA H, 1992, J AUTISM DEV DISORD, V22, P175, DOI 10.1007/BF01058149 KURITA H, 1985, J AM ACAD CHILD PSY, V24, P191, DOI 10.1016/S0002-7138(09)60447-7 Kuusikko S, 2008, J AUTISM DEV DISORD, V38, P1697, DOI 10.1007/s10803-008-0555-9 LeDoux JE, 2000, ANNU REV NEUROSCI, V23, P155, DOI 10.1146/annurev.neuro.23.1.155 Lee PR, 2007, BRAIN RES, V1156, P152, DOI 10.1016/j.brainres.2007.04.042 Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087 Lo Iacono L, 2008, J NEUROSCI, V28, P6250, DOI 10.1523/JNEUROSCI.5219-07.2008 LORD C, 1985, J AUTISM DEV DISORD, V15, P185, DOI 10.1007/BF01531604 LOUP F, 1991, BRAIN RES, V555, P220, DOI 10.1016/0006-8993(91)90345-V McAbee MD, 1999, ENDOCRINOLOGY, V140, P1807, DOI 10.1210/en.140.4.1807 MCCARTHY M, 1991, BEHAV EFFECTS OXYTOC, P195 McCarthy MM, 1996, PHYSIOL BEHAV, V60, P1209 McEwen B, 1984, FRONT NEUROENDOCRIN, V8, P153 MCLENNAN JD, 1993, J AUTISM DEV DISORD, V23, P217, DOI 10.1007/BF01046216 Mehler MF, 2008, ANN NEUROL, V64, P602, DOI 10.1002/ana.21595 Meinhardt U, 2002, SEMIN REPROD MED, V20, P277, DOI 10.1055/s-2002-35374 Meyer U, 2007, NEUROSCIENTIST, V13, P241, DOI 10.1177/1073858406296401 Migeon CJ, 1998, HORM RES, V50, P245, DOI 10.1159/000023285 Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3 Morilak DA, 2005, PROG NEURO-PSYCHOPH, V29, P1214, DOI 10.1016/j.pnpbp.2005.08.007 Mueller BR, 2008, J NEUROSCI, V28, P9055, DOI 10.1523/JNEUROSCI.1424-08.2008 Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0 Muller JF, 2007, J COMP NEUROL, V505, P314, DOI 10.1002/ene.21486 Muris P, 1998, J ANXIETY DISORD, V12, P387, DOI 10.1016/S0887-6185(98)00022-X Neumann ID, 2000, NEUROSCIENCE, V95, P567 Paton JJ, 2006, NATURE, V439, P865, DOI 10.1038/nature04490 Penn HE, 2006, CHILD NEUROPSYCHOL, V12, P57, DOI 10.1080/09297040500253546 Pfaff DW, 2006, BRAIN AROUSAL INFORM Pfeiffer B, 2005, AM J OCCUP THER, V59, P335 Phan KL, 2006, BIOL PSYCHIAT, V59, P424, DOI 10.1016/j.biopsych.2005.08.012 Phelps EA, 2005, NEURON, V48, P175, DOI 10.1016/j.neuron.2005.09.025 Piven J, 1999, AM J PSYCHIAT, V156, P557 Prather MD, 2001, NEUROSCIENCE, V106, P653, DOI 10.1016/S0306-4522(01)00445-6 QuinonesJenab V, 1997, NEUROENDOCRINOLOGY, V65, P9, DOI 10.1159/000127160 Rogers SJ, 2004, MENT RETARD DEV D R, V10, P139, DOI 10.1002/mrdd.20027 Roozendaal B, 2006, P NATL ACAD SCI USA, V103, P6741, DOI 10.1073/pnas.0601874103 Roozendaal B, 2008, J NEUROSCI, V28, P6642, DOI 10.1523/JNEUROSCI.1336-08.2008 Roozendaal B, 2004, J NEUROSCI, V24, P8161, DOI 10.1523/JNEUROSCI.2574-04.2004 Roozendaal B, 2006, NEUROSCIENCE, V138, P901, DOI 10.1016/j.neuroscience.2005.07.049 Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98 Rosenkranz JA, 2002, J NEUROSCI, V22, P324 Rosenkranz JA, 2001, J NEUROSCI, V21, P4090 Ross HE, 2009, NEUROSCIENCE, V162, P892, DOI 10.1016/j.neuroscience.2009.05.055 Sarkar P, 2007, CLIN ENDOCRINOL, V66, P636, DOI 10.1111/j.1365-2265.2007.02785.x SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8 Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004 Scott FJ, 2002, AUTISM, V6, P231, DOI 10.1177/1362361302006003002 Sgoifo A, 1999, PHYSIOL BEHAV, V67, P733, DOI 10.1016/S0031-9384(99)00134-1 SIMERLY RB, 1990, J COMP NEUROL, V294, P76, DOI 10.1002/cne.902940107 Skokauskas N, 2010, PSYCHOPATHOLOGY, V43, P8, DOI 10.1159/000255958 South M, 2008, J INT NEUROPSYCH SOC, V14, P42, DOI 10.1017/S1355617708080107 Sparks BF, 2002, NEUROLOGY, V59, P184 Spezio ML, 2007, J NEUROSCI, V27, P3994, DOI 10.1523/JNEUROSCI.3789-06.2007 STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9 Truitt WA, 2007, PSYCHOPHARMACOLOGY, V191, P107, DOI 10.1007/s00213-006-0674-y Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6 van Vliet J, 2007, CELL MOL LIFE SCI, V64, P1531, DOI 10.1007/s00018-007-6526-z VOLKMAR FR, 1993, J AUTISM DEV DISORD, V23, P579, DOI 10.1007/BF01046103 Waddell J, 2008, J NEUROSCI, V28, P5290, DOI 10.1523/JNEUROSCI.1129-08.2008 Waldherr M, 2007, P NATL ACAD SCI USA, V104, P16681, DOI 10.1073/pnas.0705860104 Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974 Westenbroek C, 2003, NEUROSCIENCE, V121, P189, DOI 10.1016/S0306-4522(03)00367-1 White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003 Wiggins LD, 2009, AUTISM, V13, P357, DOI 10.1177/1362361309105662 Wilson S, 2003, DEV MED CHILD NEUROL, V45, P508 WING L, 1981, PSYCHIAT RES, V5, P129, DOI 10.1016/0165-1781(81)90043-3 Winslow JT, 2003, NEUROPSYCHOPHARMACOL, V28, P910, DOI 10.1038/sj.npp.1300128 Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013 Zimmerman AW, 2007, BRAIN BEHAV IMMUN, V21, P351, DOI 10.1016/j.bbi.2006.08.005 ZINGG J, 2002, BRAIN BEHAV, P779 NR 146 TC 22 Z9 22 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2011 VL 4 IS 3 BP 163 EP 176 DI 10.1002/aur.191 PG 14 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 781CO UT WOS:000291908400001 PM 21465671 ER PT J AU Schoen, E Paul, R Chawarska, K AF Schoen, Elizabeth Paul, Rhea Chawarska, Katarzyna TI Phonology and Vocal Behavior in Toddlers With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism; phonology; autism spectrum disorders; atypical; vocalizations ID HIGH-FUNCTIONING AUTISM; 2ND YEAR; PRESCHOOL-CHILDREN; ASPERGER-SYNDROME; LANGUAGE; SPEECH; COMMUNICATION; DIAGNOSIS; STABILITY; PROFILES AB The purpose of this study is to examine the phonological and other vocal productions of children, 18-36 months, with autism spectrum disorder (ASD) and to compare these productions to those of age-matched and language-matched controls. Speech samples were obtained from 30 toddlers with ASD, 11 age-matched toddlers and 23 language-matched toddlers during either parent-child or clinician-child play sessions. Samples were coded for a variety of speech-like and nonspeech vocalization productions. Toddlers with ASD produced speech-like vocalizations similar to those of language-matched peers, but produced significantly more atypical nonspeech vocalizations when compared to both control groups. Toddlers with ASD show speech-like sound production that is linked to their language level, in a manner similar to that seen in typical development. The main area of difference in vocal development in this population is in the production of atypical vocalizations. Findings suggest that toddlers with ASDs do not tune into the language model of their environment. Failure to attend to the ambient language environment negatively impacts the ability to acquire spoken language. Autism Res 2011,4:177-188. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Schoen, Elizabeth; Paul, Rhea; Chawarska, Katarzyna] Yale Univ, Yale Child Study Ctr, New Haven, CT 06510 USA. RP Schoen, E (reprint author), Yale Univ, Yale Child Study Ctr, 40 Temple St 7D, New Haven, CT 06510 USA. EM elizabeth.schoen@yale.edu FU National Institute of Mental Health [P50 MH81756]; National Institute of Environmental Health Sciences; National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke [U54 MH66494]; NIDCD [K24 HD045576]; NIMH Autism Center of Excellence [P50 MH81756] FX Grant sponsor: National Institute of Mental Health; Grant number: P50 MH81756; Grant sponsors: National Institute of Environmental Health Sciences; National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Grant number: U54 MH66494; Grant sponsor: NIDCD MidCareer Development Award; Grant number: K24 HD045576; Grant sponsor: NIMH Autism Center of Excellence Grant; Grant number: # P50 MH81756. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT BARTAK L, 1975, BRIT J PSYCHIAT, V126, P127, DOI 10.1192/bjp.126.2.127 BARTOLUCCI G, 1976, J AUTISM CHILD SCHIZ, V6, P303, DOI 10.1007/BF01537908 Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093 Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022 Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x Chawarska K, 2007, J AUTISM DEV DISORD, V37, P62, DOI 10.1007/s10803-006-0330-8 CHAWARSKA K, 2005, HDB AUTISM PERVASIVE, V1, pR25 Cleland J, 2010, INT J SPEECH-LANG PA, V12, P69, DOI 10.3109/17549500903469980 Cohen D., 1988, STAT POWER ANAL BEHA Cox A, 1999, J CHILD PSYCHOL PSYC, V40, P719, DOI 10.1111/1469-7610.00488 ELLIOTT MJ, 1993, THESIS U N CAROLINA Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493 Fombonne E, 2005, J APPL RES INTELLECT, V18, P281, DOI 10.1111/j.1468-3148.2005.00266.x Gernsbacher MA, 2008, J CHILD PSYCHOL PSYC, V49, P43, DOI 10.1111/j.1469-7610.2007.01820.x GIBBON F, 2004, INT ASS LOG PHON C P KENT RD, 1982, J ACOUST SOC AM, V72, P353, DOI 10.1121/1.388089 KIRKPATRICK E, 1984, AUSTR J HUMAN COMMUN, V12, P55 Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287 Klin A, 2004, AM J PSYCHIAT, V161, P1981, DOI 10.1176/appi.ajp.161.11.1981 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 LORD C, 2006, ARCH GEN PSYCHIAT, V63, P697 Luyster R, 2009, J AUTISM DEV DISORD, V39, P1305, DOI 10.1007/s10803-009-0746-z McCleery JP, 2006, J COMMUN DISORD, V39, P217, DOI 10.1016/j.jcomdis.2005.12.002 Mullen E, 1995, MULLEN SCALES EARLY Olswang L., 1987, ASSESSING PRELINGUIS PAUL R, J CHILD PSY IN PRESS PAUL R, 1992, J SPEECH HEAR RES, V35, P99 Paul R, 2007, J SPEECH LANG HEAR R, V50, P1350, DOI 10.1044/1092-4388(2007/094) Paul R, 2008, AUTISM RES, V1, P97, DOI 10.1002/aur.12 PIERCE S, 1977, J AUTISM CHILD SCHIZ, V7, P121, DOI 10.1007/BF01537724 PRATHER EM, 1975, J SPEECH HEAR DISORD, V40, P179 Prizant BM, 1996, J AUTISM DEV DISORD, V26, P173, DOI 10.1007/BF02172007 Rapin I, 2009, DEV NEUROPSYCHOL, V34, P66, DOI 10.1080/87565640802564648 RICKS DM, 1976, EARLY CHILDHOOD AUTI, P93 Rogers S, 2006, SOCIAL COMMUNICATION, P143 RUTTER M, 1992, SPECIFIC SPEECH AND LANGUAGE DISORDERS IN CHILDREN : CORRELATES, CHARACTERISTICS AND OUTCOMES, P63 SCHOEN E, 2009, SPEECH SOUND DISORDE, P181 Sheinkopf SJ, 2000, J AUTISM DEV DISORD, V30, P345, DOI 10.1023/A:1005531501155 SHRIBERG L, J AUTISM DE IN PRESS SHRIBERG LD, 1982, J SPEECH HEAR DISORD, V47, P256 SHRIBERG LD, 1993, J SPEECH HEAR RES, V36, P105 SHRIBERG LD, 1994, J SPEECH HEAR RES, V37, P1151 Shriberg LD, 2001, J SPEECH LANG HEAR R, V44, P1097, DOI 10.1044/1092-4388(2001/087) SMIT AB, 1990, J SPEECH HEAR DISORD, V55, P779 Sparrow S, 1984, VINELAND ADAPTIVE BE Stahmer AC, 2004, J POSIT BEHAV INTERV, V6, P67, DOI 10.1177/10983007040060020201 Stoel-Gammon C., 1998, EXPLORING SPEECH LAN, P25 SZYPULSKI TA, 2003, ADV SPEECH LANGUAGE, V13, P9 Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335 Templin M., 1957, CERTAIN LANGUAGE SKI Thal DJ, 1995, APPL PSYCHOLINGUIST, V16, P407 VELLEMAN S, 1996, PATHOLOGIES SPEECH L, P27 VELLEMAN SL, 2009, SPEECH SOUND DISORDE, P141 WALLACE M, 2008, INT M AUT RES LOND Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4 WETHERBY AM, 1989, J SPEECH HEAR DISORD, V54, P148 Wetherby AM, 2002, COMMUNICATION SYMBOL Wetherby AM, 2004, J AUTISM DEV DISORD, V34, P473, DOI 10.1007/s10803-004-2544-y Wolk L, 2000, J COMMUN DISORD, V33, P371, DOI 10.1016/S0021-9924(00)00021-6 Wolk Lesley, 1993, Journal of Communication Disorders, V26, P161, DOI 10.1016/0021-9924(93)90006-V NR 61 TC 8 Z9 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2011 VL 4 IS 3 BP 177 EP 188 DI 10.1002/aur.183 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 781CO UT WOS:000291908400002 PM 21308998 ER PT J AU Cottrell, CE Bir, N Varga, E Alvarez, CE Bouyain, S Zernzach, R Thrush, DL Evans, J Trimarchi, M Butter, EM Cunningham, D Gastier-Foster, JM McBride, KL Herman, GE AF Cottrell, Catherine E. Bir, Natalie Varga, Elizabeth Alvarez, Carlos E. Bouyain, Samuel Zernzach, Randall Thrush, Devon L. Evans, Johnna Trimarchi, Michael Butter, Eric M. Cunningham, David Gastier-Foster, Julie M. McBride, Kim L. Herman, Gail E. TI Contactin 4 as an Autism Susceptibility Locus SO AUTISM RESEARCH LA English DT Article DE contactin 4; autism; autism spectrum disorder; 3p26 deletion; contactins; susceptibility locus ID 3P DELETION SYNDROME; SPECTRUM DISORDERS; HUMAN GENOME; MOLECULAR CHARACTERIZATION; DEVELOPMENTAL DELAY; GENE-EXPRESSION; MUTATIONS; REARRANGEMENTS; ASSOCIATION; SUPERFAMILY AB Structural and sequence variation have been described in several members of the contactin (CNTN) and contactin-associated protein (CNTNAP) gene families in association with neurodevelopmental disorders, including autism. Using array comparative genome hybridization (CGH), we identified a maternally inherited similar to 535 kb deletion at 3p26.3 encompassing the 5' end of the contactin 4 gene (CNTN4) in a patient with autism. Based on this finding and previous reports implicating genomic rearrangements of CNTN4 in autism spectrum disorders (ASDs) and 3p(-) microdeletion syndrome, we undertook sequencing of the coding regions of the gene in a local ASD cohort in comparison with a set of controls. Unique missense variants were identified in 4 of 75 unrelated individuals with ASD, as well as in 1 of 107 controls. All of the amino acid substitutions were nonsynonomous, occurred at evolutionarily conserved positions, and were, thus, felt likely to be deleterious. However, these data did not reach statistical significance, nor did the variants segregate with disease within all of the ASD families. Finally, there was no detectable difference in binding of two of the variants to the interacting protein PTPRG in vitro. Thus, additional larger studies will be necessary to determine whether CNTN4 functions as an autism susceptibility locus in combination with other genetic and/or environmental factors. Autism Res 2011,4:189-199. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Bir, Natalie; Varga, Elizabeth; Alvarez, Carlos E.; Evans, Johnna; Trimarchi, Michael; Cunningham, David; McBride, Kim L.; Herman, Gail E.] Nationwide Childrens Hosp, Ctr Mol & Human Genet, Res Inst, Columbus, OH 43205 USA. [Cottrell, Catherine E.; Thrush, Devon L.; Gastier-Foster, Julie M.] Nationwide Childrens Hosp, Dept Pathol & Lab Med, Columbus, OH 43205 USA. [Alvarez, Carlos E.; Thrush, Devon L.; Butter, Eric M.; Cunningham, David; Gastier-Foster, Julie M.; McBride, Kim L.; Herman, Gail E.] Ohio State Univ, Dept Pediat, Columbus, OH 43205 USA. [Gastier-Foster, Julie M.] Ohio State Univ, Dept Pathol, Columbus, OH 43205 USA. [Bouyain, Samuel] Univ Missouri, Div Mol Biol & Biochem, Sch Biol Sci, Kansas City, MO 64110 USA. [Zernzach, Randall] Dept Pediat, Wright Patterson AFB, OH USA. RP Herman, GE (reprint author), Nationwide Childrens Hosp, Ctr Mol & Human Genet, Res Inst, 700 Childrens Dr,Room W403, Columbus, OH 43205 USA. EM Gail.Herman@nationwidechildrens.org RI Gastier-Foster, Julie/E-3105-2011; McBride, Kim/A-5879-2008 OI McBride, Kim/0000-0002-8407-8942 FU USAF Department of Defense [FA7014-09-2-0004]; NIH [R21 HG004663, R01 GM088806] FX Grant sponsor: USAF Department of Defense grant/Cooperative Agreement; Grant number: FA7014-09-2-0004; Grant sponsor: NIH; Grant numbers: R21 HG004663; R01 GM088806. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Alarcon M, 2008, AM J HUM GENET, V82, P150, DOI 10.1016/j.ajhg.2007.09.005 ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999 Arking DE, 2008, AM J HUM GENET, V82, P160, DOI 10.1016/j.ajhg.2007.09.015 Bakkaloglu B, 2008, AM J HUM GENET, V82, P165, DOI 10.1016/j.ajhg.2007.09.017 Bejjani BA, 2005, AM J MED GENET A, V134A, P259, DOI 10.1002/ajmg.a.30621 Berglund EO, 1999, NEURON, V24, P739, DOI 10.1016/S0896-6273(00)81126-5 Bouyain S, 2010, P NATL ACAD SCI USA, V107, P2443, DOI 10.1073/pnas.0911235107 Bradley WEC, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009401 Burbach JPH, 2009, TRENDS NEUROSCI, V32, P69, DOI 10.1016/j.tins.2008.11.002 Compton AG, 2008, AM J HUM GENET, V83, P714, DOI 10.1016/j.ajhg.2008.10.022 Dijkhuizen T, 2006, AM J MED GENET A, V140A, P2482, DOI 10.1002/ajmg.a.31487 Fernandez T, 2008, AM J HUM GENET, V82, P1385, DOI 10.1016/j.ajhg.2008.04.021 Fernandez T, 2004, AM J HUM GENET, V74, P1286, DOI 10.1086/421474 Fernandez TV, 2008, AM J MED GENET A, V146A, P2746, DOI 10.1002/ajmg.a.32533 Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953 Iafrate AJ, 2004, NAT GENET, V36, P949, DOI 10.1038/ng1416 Iwaki A, 2008, J MED GENET, V45, P32, DOI 10.1136/jmg.2007.053942 Kaneko-Goto T, 2008, NEURON, V57, P834, DOI 10.1016/j.neuron.2008.01.023 Katidou Markella, 2008, Biotechnology Journal, V3, P1564, DOI 10.1002/biot.200800281 Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376 Larkin MA, 2007, BIOINFORMATICS, V23, P2947, DOI 10.1093/bioinformatics/btm404 Li BS, 2008, AM J HUM GENET, V83, P311, DOI 10.1016/j.ajhg.2008.06.024 Malmgren H, 2007, AM J MED GENET A, V143A, P2143, DOI 10.1002/ajmg.a.31902 Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 Mefford HC, 2008, NEW ENGL J MED, V359, P1685, DOI 10.1056/NEJMoa0805384 Miura S, 2006, NEUROLOGY, V67, P1236, DOI 10.1212/01.wnl.0000238510.84932.82 Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90 Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657 Ng PC, 2001, GENOME RES, V11, P863, DOI 10.1101/gr.176601 PELES E, 1995, CELL, V82, P251, DOI 10.1016/0092-8674(95)90312-7 Pohjola P, 2010, AM J MED GENET A, V152A, P441, DOI 10.1002/ajmg.a.33215 Poliak S, 2003, J CELL BIOL, V162, P1149, DOI 10.1083/jcb.200305018 Ramensky V, 2002, NUCLEIC ACIDS RES, V30, P3894, DOI 10.1093/nar/gkf493 Roohi J, 2009, J MED GENET, V46, P176, DOI 10.1136/jmg.2008.057505 SAWAKI M, 2008, MOL CELL NEUROSCI, V39, P478 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 SHAFFER LG, 1994, AM J HUM GENET, V55, P968 Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684 SHIMODA Y, 2009, CELL ADHESION MIGRAT, V3 Shuib S, 2009, AM J MED GENET A, V149A, P2099, DOI 10.1002/ajmg.a.32824 Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 Takeda Y, 2003, J NEUROBIOL, V56, P252, DOI 10.1002/neu.10222 Altshuler D, 2010, NATURE, V467, P1061, DOI 10.1038/nature09534 Toyoshima M, 2009, DEV BIOL, V336, P192, DOI 10.1016/j.ydbio.2009.09.043 Varga EA, 2009, GENET MED, V11, P111, DOI 10.1097/GIM.0b013e31818fd762 Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974 NR 47 TC 19 Z9 20 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2011 VL 4 IS 3 BP 189 EP 199 DI 10.1002/aur.184 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 781CO UT WOS:000291908400003 PM 21308999 ER PT J AU Oblak, AL Rosene, DL Kemper, TL Bauman, ML Blatt, GJ AF Oblak, Adrian L. Rosene, Douglas L. Kemper, Thomas L. Bauman, Margaret L. Blatt, Gene J. TI Altered Posterior Cingulate Cortical Cyctoarchitecture, but Normal Density of Neurons and lnterneurons in the Posterior Cingulate Cortex and Fusiform Gyrus in Autism SO AUTISM RESEARCH LA English DT Article DE neuropathology; gamma-aminobutyric acid < neurochemistry; neuroanatomy ID FACE AREA; FUNCTIONAL CONNECTIVITY; SPECTRUM DISORDERS; DEFAULT NETWORK; BRAINS; EMOTION; ORGANIZATION; INDIVIDUALS; PARVALBUMIN; PERCEPTION AB Autism is a developmental disorder with prenatal origins, currently estimated to affect 1 in 91 children in the United States. Social-emotional deficits are a hallmark of autism and early neuropathology studies have indicated involvement of the limbic system. Imaging studies demonstrate abnormal activation of the posterior cingulate cortex (PCC), a component of the limbic system. Abnormal activation has also been noted in the fusiform gyrus (FFG), a region important for facial recognition and a key element in social interaction. A potential imbalance between excitatory and inhibitory interneurons in the cortex may contribute to altered information processing in autism. Furthermore, reduced numbers of GABA receptors have previously been reported in the autistic brain. Thionin-stained sections were used to qualitatively assess cytoarchitectonic patterning and quantitatively determine the density of neurons and immunohistochemistry was used to determine the densities of a subset of GABAergic interneurons utilizing parvalbumin- and calbindin-immunoreactivity. In autism, the PCC displayed altered cytoarchitecture with irregularly distributed neurons, poorly demarcated layers IV and V. and increased presence of white matter neurons. In contrast, no neuropathology was observed in the FFG. There was no significant difference in the density of thionin, parvalbumin, or calbindin interneurons in either region and there was a trend towards a reduced density of calbindin neurons in the PCC. This study highlights the presence of abnormal findings in the PCC, which appear to be developmental in nature and could affect the local processing of social-emotional behaviors as well as functioning of interrelated areas. Autism Res 2011,4:200-211. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Oblak, Adrian L.; Rosene, Douglas L.; Kemper, Thomas L.; Bauman, Margaret L.; Blatt, Gene J.] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA. RP Oblak, AL (reprint author), Boston Univ, Sch Med, Dept Anat & Neurobiol, 72 E Concord St,L-1004, Boston, MA 02118 USA. EM aoblak@bu.edu FU National Institutes of Health [NIH U54 MH66398]; Nancy Lurie Marks Family Foundation FX Grant sponsor: National Institutes of Health; Grant number: NIH U54 MH66398; Grant sponsor: Nancy Lurie Marks Family Foundation. CR American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 BAUMAN M, 1985, NEUROLOGY, V35, P866 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Brodmann K., 1909, VERGLEICHENDE LOKALI Buckner RL, 2008, ANN NY ACAD SCI, V1124, P1, DOI 10.1196/annals.1440.011 Casanova MF, 2002, J CHILD NEUROL, V17, P515, DOI 10.1177/088307380201700708 Casanova MF, 2002, J CHILD NEUROL, V17, P692, DOI 10.1177/088307380201700908 Casanova MF, 2004, ANN NEUROL, V56, P453, DOI 10.1002/ana.20196 CELIO MR, 1981, NATURE, V293, P300, DOI 10.1038/293300a0 CELIO MR, 1990, CELL CALCIUM, V11, P599, DOI 10.1016/0143-4160(90)90014-L Critchley HD, 2000, BRAIN, V123, P2203, DOI 10.1093/brain/123.11.2203 DeFelipe J, 2002, PROG BRAIN RES, V136, P215 Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618 Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100 Grelotti DJ, 2002, DEV PSYCHOBIOL, V40, P213, DOI 10.1002/dev.10028 Gundersen HJG, 1999, J MICROSC-OXFORD, V193, P199, DOI 10.1046/j.1365-2818.1999.00457.x GUNDERSEN HJG, 1988, APMIS, V96, P857 Gupta AR, 2007, BIOL PSYCHIAT, V61, P429, DOI 10.1016/j.biopsych.2006.06.020 Hall GBC, 2003, AM J PSYCHIAT, V160, P1439, DOI 10.1176/appi.ajp.160.8.1439 Harding B, 1997, GREENFIELDS NEUROPAT, P397 HSU SM, 1981, J HISTOCHEM CYTOCHEM, V29, P1349 Hutsler JJ, 2007, BIOL PSYCHIAT, V61, P449, DOI 10.1016/j.biopsych.2006.01.015 Kanwisher N, 1997, J NEUROSCI, V17, P4302 KEMPER TL, 2010, DEV NEUROPATHOLOGY A Kennedy DP, 2008, SOC COGN AFFECT NEUR, V3, P177, DOI 10.1093/scan/nsn011 Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334 Kogan MD, 2009, PEDIATRICS, V124, P1395, DOI 10.1542/peds.2009-1522 Lawrence YA, 2010, ACTA NEUROL SCAND, V121, P99, DOI 10.1111/j.1600-0404.2009.01234.x Levitt P, 2004, TRENDS NEUROSCI, V27, P400, DOI 10.1016/j.tins.2004.05.008 Li J, 2009, NEUROSCI LETT, V451, P6, DOI 10.1016/j.neulet.2008.12.039 Maddock RJ, 1999, TRENDS NEUROSCI, V22, P310, DOI 10.1016/S0166-2236(98)01374-5 MARINPADILLA M, 1988, CEREB CORTEX, V7, P1 Mountcastle VB, 1997, BRAIN, V120, P701, DOI 10.1093/brain/120.4.701 Mountcastle VB, 2003, CEREB CORTEX, V13, P2, DOI 10.1093/cercor/13.1.2 Mouton PR, 2002, PRINCIPLES PRACTICES Mukaetova-Ladinska EB, 2004, NEUROPATH APPL NEURO, V30, P615, DOI 10.1111/j.1365-2990.2004.00574.x OBLAK A, 2009, SOC NEUR C OCT 19 20 Oblak A, 2009, AUTISM RES, V2, P205, DOI 10.1002/aur.88 Okhotin V E, 2003, Neurosci Behav Physiol, V33, P177, DOI 10.1023/A:1021778015886 Palmen SJMC, 2004, BRAIN, V127, P2572, DOI 10.1093/brain/awh287 Papez JW, 1937, ARCH NEURO PSYCHIATR, V38, P725 Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059 RAKIC P, 1975, MORPHOGENESIS MALFOR, P95 RAKIC P, 1988, PROG BRAIN RES, V73, P15 ROSENE DL, 1986, J HISTOCHEM CYTOCHEM, V34, P1301 Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331 Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006 Shah NJ, 2001, BRAIN, V124, P804, DOI 10.1093/brain/124.4.804 SHATZ CJ, 1998, CEREB CORTEX, V7, P3558 SIDMAN RL, 1982, HISTOL HISTOPATHOL, P3145 Simms ML, 2009, ACTA NEUROPATHOL, V118, P673, DOI 10.1007/s00401-009-0568-2 Somogyi P, 1998, BRAIN RES REV, V26, P113, DOI 10.1016/S0165-0173(97)00061-1 Super H, 1998, BRAIN RES REV, V27, P40, DOI 10.1016/S0165-0173(98)00005-8 VANKOOTEN, 2008, NEUROLOGY, V131, P987 Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050 Vogt BA, 2006, NEUROIMAGE, V29, P452, DOI 10.1016/j.neuroimage.2005.07.048 VOGT BA, 1995, J COMP NEUROL, V359, P490, DOI 10.1002/cne.903590310 VonEconomo C, 2009, CELLULAR STRUCTURE OF THE HUMAN CEREBRAL CORTEX, P1 VONECONOMO C, 1927, ARCHIECTURE CELLULAI Wang AT, 2004, J AM ACAD CHILD PSY, V43, P481, DOI 10.1097/01.chi.0000111481.76722.66 Whitney ER, 2008, CEREBELLUM, V7, P406, DOI 10.1007/s12311-008-0043-y NR 63 TC 25 Z9 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2011 VL 4 IS 3 BP 200 EP 211 DI 10.1002/aur.188 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 781CO UT WOS:000291908400004 PM 21360830 ER PT J AU Estes, A Shaw, DWW Sparks, BF Friedman, S Giedd, JN Dawson, G Bryan, M Dager, SR AF Estes, Annette Shaw, Dennis W. W. Sparks, Bobbi F. Friedman, Seth Giedd, Jay N. Dawson, Geraldine Bryan, Matthew Dager, Stephen R. TI Basal Ganglia Morphometry and Repetitive Behavior in Young Children with Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE neuroimaging; preschoolers < pediatrics; clinical psychology; repetitive behavior; autism spectrum disorders ID HIGH-FUNCTIONING AUTISM; CAUDATE-NUCLEUS; BRAIN SIZE; AGE; PATTERNS; VOLUME; INTERESTS; INFANCY; LIFE; MRI AB We investigated repetitive and stereotyped behavior (RSB) and its relationship to morphometric measures of the basal ganglia and thalami in 3- to 4-year-old children with autism spectrum disorder (ASD; n = 77) and developmental delay without autism (DD; n = 34). Children were assessed through clinical evaluation and parent report using RSB-specific scales extracted from the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview, and the Aberrant Behavior Checklist. A subset of children with ASD (n = 45), DD (n = 14), and a group of children with typical development (TD; n = 25) were also assessed by magnetic resonance imaging. Children with ASD demonstrated elevated RSB across all measures compared to children with DD. Enlargement of the left and right striatum, more specifically the left and right putamen, and left caudate, was observed in the ASD compared to the TD group. However, nuclei were not significantly enlarged after controlling for cerebral volume. The DD group, in comparison to the ASD group, demonstrated smaller thalami and basal ganglia regions even when scaled for cerebral volume, with the exception of the left striatum, left putamen, and right putamen. Elevated RSB, as measured by the ADOS, was associated with decreased volumes in several brain regions: left thalamus, right globus pallidus, left and right putamen, right striatum and a trend for left globus pallidus and left striatum within the ASD group. These results confirm earlier reports that RSB is common early in the clinical course of ASD and, furthermore, demonstrate that such behaviors may be associated with decreased volumes of the basal ganglia and thalamus. Autism Res 2011,4:212-220. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Estes, Annette] Univ Washington, UW Autism Ctr, Dept Speech & Hearing Sci, Seattle, WA 98195 USA. [Estes, Annette; Dager, Stephen R.] Univ Washington, Autism Ctr, Seattle, WA 98195 USA. [Shaw, Dennis W. W.; Sparks, Bobbi F.; Friedman, Seth; Dager, Stephen R.] Univ Washington, Dept Radiol, Seattle, WA 98195 USA. [Giedd, Jay N.] NIMH, Bethesda, MD 20892 USA. [Dawson, Geraldine] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA. [Dawson, Geraldine] Autism Speaks, New York, NY USA. [Bryan, Matthew] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. RP Estes, A (reprint author), Univ Washington, UW Autism Ctr, Dept Speech & Hearing Sci, Box 357920, Seattle, WA 98195 USA. EM estesa@u.washington.edu RI Giedd, Jay/A-3080-2008; Giedd, Jay/B-7302-2012 OI Giedd, Jay/0000-0003-0827-3460 FU National Institute of Child Health and Human Development; National Institute on Deafness and Communication Disorders [U19HD34565]; National Institute of Child Health and Human Development [P50HD55782]; National Institute of Child Health and Human Development which is part of the Autism Centers of Excellence (ACE) [P50HD55782] FX Grant sponsors: National Institute of Child Health and Human Development; National Institute on Deafness and Communication Disorders; Grant number: U19HD34565; Grant sponsor: National Institute of Child Health and Human Development; Grant number: P50HD55782.This research was funded by a program project grant from the National Institute of Child Health and Human Development and the National Institute on Deafness and Communication Disorders (U19HD34565) which is part of the NICHD Collaborative Program of Excellence in Autism (CPEA) and a program project grant from the National Institute of Child Health and Human Development (P50HD55782) which is part of the Autism Centers of Excellence (ACE). CR Aman M., 1986, ABERRANT BEHAV CHECK Amundsen LB, 2005, J NEUROSURG ANESTH, V17, P180, DOI 10.1097/01.ana.0000171734.63879.fd Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650 Baron-Cohen S, 2005, ANNU REV NEUROSCI, V28, P109, DOI 10.1146/annurev.neuro.27.070203.144137 Bishop SL, 2006, CHILD NEUROPSYCHOL, V12, P247, DOI 10.1080/09297040600630288 Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855 Carcani-Rathwell I, 2006, J CHILD PSYCHOL PSYC, V47, P573, DOI 10.1111/j.1469-7610.2005.01565.x Courchesne E, 2001, NEUROLOGY, V57, P245 Cox A, 1999, J CHILD PSYCHOL PSYC, V40, P719, DOI 10.1111/1469-7610.00488 Cuccaro ML, 2003, CHILD PSYCHIAT HUM D, V34, P3, DOI 10.1023/A:1025321707947 DeLoache JS, 2007, DEV PSYCHOL, V43, P1579, DOI 10.1037/0012-1649.43.6.1579 DiCicco-Bloom E, 2006, J NEUROSCI, V26, P6897, DOI 10.1523/JNEUROSCI.1712-06.2006 Estes A, 2009, AUTISM, V13, P375, DOI 10.1177/1362361309105658 Estes AM, 2007, AM J MENT RETARD, V112, P439, DOI 10.1352/0895-8017(2007)112[439:LOIFPP]2.0.CO;2 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 Hardan AY, 2006, PSYCHIAT RES-NEUROIM, V147, P145, DOI 10.1016/j.pscychresns.2005.12.009 Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366 Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110 Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040 Hwang J, 2006, AM J PSYCHIAT, V163, P276, DOI 10.1176/appi.ajp.163.2.276 Langen M, 2007, BIOL PSYCHIAT, V62, P262, DOI 10.1016/j.biopsych.2006.09.040 Lord C, 2003, AUTISM DIAGNOSTIC OB Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694 Lord C, 1995, J CHILD PSYCHOL PSYC, V36, P1365, DOI 10.1111/j.1469-7610.1995.tb01669.x McAlonan GM, 2008, J CHILD PSYCHOL PSYC, V49, P1287, DOI 10.1111/j.1469-7610.2008.01933.x Miwa H, 2007, J NEUROL, V254, P61, DOI 10.1007/s00415-007-5010-x Mooney EL, 2006, EUR CHILD ADOLES PSY, V15, P12, DOI 10.1007/s00787-006-0499-6 Morgan L, 2008, J CHILD PSYCHOL PSYC, V49, P826, DOI 10.1111/j.1469-7610.2008.01904.x Mullen E., 1997, MULLEN SCALES EARLY Richler J, 2007, J AUTISM DEV DISORD, V37, P73, DOI 10.1007/s10803-006-0332-6 Rutter M., 2003, AUTISM DIAGNOSTIC IN Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2 Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846 South M, 2005, J AUTISM DEV DISORD, V35, P145, DOI 10.1007/s10803-005-1992-3 Sparks BF, 2002, NEUROLOGY, V59, P184 Stone WL, 1999, J CHILD PSYCHOL PSYC, V40, P219, DOI 10.1017/S0021963098003370 Symons FJ, 2005, J INTELL DISABIL RES, V49, P144, DOI 10.1111/j.1365-2788.2004.00632.x Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x THELEN E, 1981, DEV PSYCHOL, V17, P237, DOI 10.1037//0012-1649.17.3.237 Tsatsanis KD, 2003, BIOL PSYCHIAT, V53, P121, DOI 10.1016/S0006-3223(02)01530-5 Voelbel GT, 2006, BIOL PSYCHIAT, V60, P942, DOI 10.1016/j.biopsych.2006.03.071 Werner E, 2000, J AUTISM DEV DISORD, V30, P157, DOI 10.1023/A:1005463707029 NR 42 TC 20 Z9 21 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2011 VL 4 IS 3 BP 212 EP 220 DI 10.1002/aur.193 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 781CO UT WOS:000291908400005 PM 21480545 ER PT J AU Griswold, AJ Ma, DQ Sacharow, SJ Robinson, JL Jaworski, JM Wright, HH Abramson, RK Lybaek, H Oyen, N Cuccaro, ML Gilbert, JR Pericak-Vance, MA AF Griswold, Anthony J. Ma, Deqiong Sacharow, Stephanie J. Robinson, Joycelyn L. Jaworski, James M. Wright, Harry H. Abramson, Ruth K. Lybaek, Helle Oyen, Nina Cuccaro, Michael L. Gilbert, John R. Pericak-Vance, Margaret A. TI A De Novo 1.5 Mb Microdeletion on Chromosome 14q23.2-23.3 in a Patient With Autism and Spherocytosis SO AUTISM RESEARCH LA English DT Article DE genetics; copy number variation < molecular genetics; molecular genetics ID COPY NUMBER VARIATION; NUCLEOTIDE EXCHANGE-FACTOR; LINKED MENTAL-RETARDATION; HEREDITARY SPHEROCYTOSIS; SPECTRUM DISORDERS; BETA-SPECTRIN; RETT-SYNDROME; MUTATIONS; GENE; IDENTIFICATION AB Autism is a neuro-developmental disorder characterized by deficits in social interaction and communication as well as restricted interests or repetitive behaviors. Cytogenetic studies have implicated large chromosomal aberrations in the etiology of approximately 5-7% of autism patients, and the recent advent of array-based techniques allows the exploration of submicroscopic copy number variations (CNVs). We genotyped a 14-year-old boy with autism, spherocytosis and other physical dysmorphia, his parents, and two non-autistic siblings with the Illumina Human 1M Beadchip as part of a study of the molecular genetics of autism and determined copy number variants using the PennCNV algorithm. We identified and validated a de novo 1.5 Mb microdeletion of 14q23.2-23.3 in our autistic patient. This region contains 15 genes, including spectrin beta (SPTB), encoding a cytoskeletal protein previously associated with spherocytosis, methylenetetrahydrofolate dehydrogenase 1 (MTHED1), a folate metabolizing enzyme previously associated with bipoloar disorder and schizophrenia, pleckstrin homology domain-containing family G member 3 (PLEKHG3), a guanide nucleotide exchange enriched in the brain, and churchill domain containing protein 1 (CHURC1), homologs of which regulate neuronal development in model organisms. While a similar deletion has previously been reported in a family with spherocytosis, severe learning disabilities, and mild mental retardation, this is the first implication of chr14q23.2-23.3 in the etiology of autism and points to MTHED1, PLEKHG3, and CHURC1 as potential candidate genes contributing to autism risk. Autism Res 2011,4:221-227. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Griswold, Anthony J.; Ma, Deqiong; Robinson, Joycelyn L.; Jaworski, James M.; Cuccaro, Michael L.; Gilbert, John R.; Pericak-Vance, Margaret A.] Univ Miami, John P Hussman Inst Human Genom, Miami, FL 33136 USA. [Sacharow, Stephanie J.] Univ Miami, Dept Human Genet, Miller Sch Med, Miami, FL 33136 USA. [Wright, Harry H.; Abramson, Ruth K.] Univ S Carolina, Sch Med, Columbia, SC USA. [Lybaek, Helle; Oyen, Nina] Haukeland Hosp, Ctr Med Genet & Mol Med, N-5021 Bergen, Norway. RP Pericak-Vance, MA (reprint author), Univ Miami, John P Hussman Inst Human Genom, 1501 NW 10th Ave, Miami, FL 33136 USA. EM mpericak@med.miami.edu RI Griswold, Anthony/B-7507-2012 FU National Institute of Mental Health [5R01MH080647-13]; National Institute of Neurological Disorders and Stroke [5P01NS026630-20]; Hussman Foundation FX Grant sponsor: National Institute of Mental Health; Grant number: 5R01MH080647-13; Grant sponsor: National Institute of Neurological Disorders and Stroke; Grant number: 5P01NS026630-20; Grant sponsor: The Hussman Foundation. CR Amir RE, 1999, NAT GENET, V23, P185 BAILEY A, 1995, PSYCHOL MED, V25, P63 BECKER PS, 1993, J CLIN INVEST, V92, P612, DOI 10.1172/JCI116628 Bienvenu T, 2000, HUM MOL GENET, V9, P1377, DOI 10.1093/hmg/9.9.1377 Bolton-Maggs PHB, 2004, ARCH DIS CHILD, V89, P809, DOI 10.1136/adc.2003.034587 NELLIST M, 1993, CELL, V75, P1305 Felder B, 2009, AM J MED GENET A, V149A, P952, DOI 10.1002/ajmg.a.32779 Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953 GOODMAN SR, 1982, BLOOD, V60, P772 Hassoun H, 1996, BLOOD, V87, P2538 Hol FA, 1998, CLIN GENET, V53, P119 Iafrate A. J., 2004, NAT GENET, V36, P949, DOI DOI 10.1038/NG1416 Ishikawa K, 2005, AM J HUM GENET, V77, P280, DOI 10.1086/432518 Kempisty B, 2007, PSYCHIAT GENET, V17, P177, DOI 10.1097/YPG.0b013e328029826f Kumar RA, 2009, J MED GENET, V47, P81 Kusenda M, 2008, CYTOGENET GENOME RES, V123, P36, DOI 10.1159/000184690 Kutsche K, 2000, NAT GENET, V26, P247 Lord C., 1999, AUTISM DIAGNOSTIC OB LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lybaek H, 2008, CLIN GENET, V74, P553, DOI 10.1111/j.1399-0004.2008.01072.x Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x Marco EJ, 2008, J MED GENET, V45, P100, DOI 10.1136/jmg.2007.052324 Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 RITVO ER, 1985, AM J PSYCHIAT, V142, P74 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 Sheng GJ, 2003, CELL, V115, P603, DOI 10.1016/S0092-8674(03)00927-9 Sparrow S, 1984, VINELAND ADAPTIVE BE Wang K, 2007, GENOME RES, V17, P1665, DOI 10.1101/gr.6861907 Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Wechsler D., 2003, WECHSLER INTELLIGENC NR 30 TC 9 Z9 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2011 VL 4 IS 3 BP 221 EP 227 DI 10.1002/aur.186 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 781CO UT WOS:000291908400006 PM 21360829 ER PT J AU Kantojarvi, K Kotala, I Rehnstrom, K Ylisaukko-oja, T Vanhala, R von Wendt, TN von Wendt, L Jarvela, I AF Kantojarvi, Katri Kotala, Ilona Rehnstrom, Karola Ylisaukko-oja, Tero Vanhala, Raija von Wendt, Taina Nieminen von Wendt, Lennart Jarvela, Irma TI Fine Mapping of Xq11.1-q21.33 and Mutation Screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for Autism Spectrum Disorders (ASD) SO AUTISM RESEARCH LA English DT Article DE ACSL4; autism spectrum disorders; DLG3; gene; IL1RAPL2; linkage; RPS6KA6; single nucleotide polymorphism; ZNF711; XLMR ID LINKED MENTAL-RETARDATION; X-CHROMOSOME; GENOMEWIDE SCREEN; SUSCEPTIBILITY LOCI; LINKAGE ANALYSIS; GENETIC-LINKAGE; FAMILY; REARRANGEMENTS; VARIANTS; KINASE AB About 80% of cases with autism express intellectual disability. Both in autism and in mental retardation without autism the majority of the cases are males, suggesting a X-chromosomal effect. In fact, some molecular evidence has been obtained for a common genetic background for autism spectrum disorders (ASD) and X-linked mental retardation (XLMR). In several genome-wide scans (GWS), evidence for linkage at X-chromosome has been reported including the GWS of Finnish ASD families with the highest multipoint lod score (MLS) of 2.75 obtained close to DXS7132 at Xq11.1. To further dissect the relationship between autism and genes implicated in XLMR, we have fine-mapped Xq11.1-q21.33 and analyzed five candidate genes in the region. We refined the region using 26 microsatellite markers and linkage analysis in 99 Finnish families with ASD. The most significant evidence for linkage was observed at DXS1225 on Xq21.1 with a nonparametric multipoint NPL(all) value of 3.43 (P = 0.0004). We sequenced the coding regions and splice sites of RPS6KA6 and ZNF711 residing at the peak region in 42 male patients from families contributing to the linkage. We also analyzed ACSL4 and DLG3, which have previously been known to cause XLMR and IL1RAPL2, a homologous gene for IL1RAPL1 that is mutated in autism and XLMR. A total of six novel and 11 known single nucleotide polymorphisms were identified. Further studies are warranted to analyze the candidate genes at Xq11.1-q21.33. Autism Res 2011,4:228-233. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Kantojarvi, Katri; Kotala, Ilona; Rehnstrom, Karola; Ylisaukko-oja, Tero; Jarvela, Irma] Univ Helsinki, Dept Med Genet, Haartman Inst, Helsinki 00251, Finland. [Rehnstrom, Karola; Ylisaukko-oja, Tero] Inst Welf & Hlth, Dept Mol Med, Helsinki, Finland. [Vanhala, Raija; von Wendt, Taina Nieminen; von Wendt, Lennart] Hosp Children & Adolescents, Dept Child Neurol, Helsinki, Finland. [Jarvela, Irma] Univ Helsinki, Cent Hosp, Mol Genet Lab, Helsinki, Finland. RP Jarvela, I (reprint author), Univ Helsinki, Dept Med Genet, Haartman Inst, PL104, Helsinki 00251, Finland. EM irma.jarvela@kolumbus.fi RI Jarvela, Irma/L-5836-2013 FU Helsinki University [TYH7227]; Academy of Finland Helsinki Finland; Medical Society of Finland, Helsinki, Finland; Cure Autism Now; European Union [512158] FX Grant sponsor: Helsinki University Hospital Research Funding; Grant number: #TYH7227; Grant sponsors: The Academy of Finland Helsinki Finland; The Medical Society of Finland, Helsinki, Finland; Cure Autism Now; European Union; Grant number: #512158. CR Abecasis GR, 2002, NAT GENET, V30, P97, DOI 10.1038/ng786 Auranen M, 2002, AM J HUM GENET, V71, P777, DOI 10.1086/342720 Awadalla P, 2010, AM J HUM GENET, V87, P316, DOI 10.1016/j.ajhg.2010.07.019 Bhat SS, 2008, CLIN GENET, V73, P94, DOI 10.1111/j.1399-0004.2007.00920.x Chiurazzi P, 2008, EUR J HUM GENET, V16, P422, DOI 10.1038/sj.ejhg.5201994 Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009 Colleaux L, 1996, J MED GENET, V33, P353, DOI 10.1136/jmg.33.5.353 Dummler BA, 2005, J BIOL CHEM, V280, P13304, DOI 10.1074/jbc.M408194200 Ferrante MI, 2001, GENE, V275, P217, DOI 10.1016/S0378-1119(01)00659-X Gecz J, 2009, TRENDS GENET, V25, P308, DOI 10.1016/j.tig.2009.05.002 Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953 Guilmatre A, 2009, ARCH GEN PSYCHIAT, V66, P947, DOI 10.1001/archgenpsychiatry.2009.80 Hallmayer J, 1996, ARCH GEN PSYCHIAT, V53, P985 Hiekkalinna T, 2005, TWIN RES HUM GENET, V8, P16, DOI 10.1375/twin.8.1.16 Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136 Jin H, 2000, EUR J HUM GENET, V8, P87, DOI 10.1038/sj.ejhg.5200415 KLEEFSTRA T, 2005, CLIN GENET, V69, P197 Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137 Lepretre F, 2003, CYTOGENET GENOME RES, V101, P124, DOI 10.1159/000074167\ Liu JJ, 2001, AM J HUM GENET, V69, P327, DOI 10.1086/321980 Lugtenberg D, 2006, J MED GENET, V43, P362, DOI 10.1136/jmg.2005.036178 Madrigal I, 2007, BMC GENOMICS, V8, DOI 10.1186/1471-2164-8-443 Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 O'Connell JR, 1998, AM J HUM GENET, V63, P259, DOI 10.1086/301904 Philippe A, 1999, HUM MOL GENET, V8, P805, DOI 10.1093/hmg/8.5.805 Piton A, 2008, HUM MOL GENET, V17, P3965, DOI 10.1093/hmg/ddn300 Qiao Y, 2008, CLIN GENET, V74, P134, DOI 10.1111/j.1399-0004.2008.01028.x Renieri A, 2005, J CELL PHYSIOL, V204, P8, DOI 10.1002/jcp.20296 Ropers HH, 2005, NAT REV GENET, V6, P46, DOI 10.1038/nrg1501 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 Shao YJ, 2002, AM J MED GENET, V114, P99, DOI 10.1002/ajmg.10153 Smalley SL, 1997, AM J HUM GENET, V60, P1276, DOI 10.1086/515485 Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 Tabolacci E, 2006, AM J MED GENET A, V140A, P482, DOI 10.1002/ajmg.a.31107 Tarpey P, 2004, AM J HUM GENET, V75, P318, DOI 10.1086/422703 Tarpey PS, 2009, NAT GENET, V41, P535, DOI 10.1038/ng.367 Trivier E, 1996, NATURE, V384, P567, DOI 10.1038/384567a0 Vincent JB, 2005, PSYCHIAT GENET, V15, P83, DOI 10.1097/00041444-200506000-00004 Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Ylisaukko-oja T, 2005, EUR J HUM GENET, V13, P1285, DOI 10.1038/sj.ejhg.5201474 Yntema HG, 1999, GENOMICS, V62, P332, DOI 10.1006/geno.1999.6004 Yonan AL, 2003, AM J HUM GENET, V73, P886, DOI 10.1086/378778 Zanni G, 2010, NEUROGENETICS, V11, P251, DOI 10.1007/s10048-009-0224-y NR 43 TC 3 Z9 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2011 VL 4 IS 3 BP 228 EP 233 DI 10.1002/aur.187 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 781CO UT WOS:000291908400007 PM 21384559 ER PT J AU Wintle, RF Lionel, AC Hu, PZ Ginsberg, SD Pinto, D Thiruvahindrapduram, B Wei, J Marshall, CR Pickett, J Cook, EH Scherer, SW AF Wintle, Richard F. Lionel, Anath C. Hu, Pingzhao Ginsberg, Stephen D. Pinto, Dalila Thiruvahindrapduram, Bhooma Wei, John Marshall, Christian R. Pickett, Jane Cook, Edwin H. Scherer, Stephen W. TI A Genotype Resource for Postmortem Brain Samples from the Autism Tissue Program SO AUTISM RESEARCH LA English DT Article DE autism; autism spectrum disorder; brain; brodmann area 19; copy number variation; genome-wide; microarray; single nucleotide polymorphism ID COPY NUMBER VARIATION; HIDDEN-MARKOV MODEL; SPECTRUM DISORDERS; RISK; ASSOCIATE; DELETIONS AB The Autism Tissue Program (ATP), a science program of Autism Speaks, provides researchers with access to well-characterized postmortem brain tissues. Researchers access these tissues through a peer-reviewed, project-based approval process, and obtain related clinical information from a secure, online informatics portal. However, few of these samples have DNA banked from other sources (such as a blood sample from the same individual), hindering genotype phenotype correlation and interpretation of gene expression data derived from the banked brain tissue. Here, we describe an initiative to extract DNA from Brodmann Area 19, and genotype these samples using both the Affymetrix Genome-Wide Human SNP Array 6.0 and the Illumina Human1M-Duo DNA Analysis Bead Chip genome-wide microarray technologies. We additionally verify reported gender, and infer ethnic background from the single nucleotide polymorphism data. We have also used a rigorous, multiple algorithm approach to identify genomic copy number variation (CNV) from these array data. Following an initial proof of principle study using two samples, 52 experimental samples, consisting of 27 subjects with confirmed or suspected autism and related disorders, 5 subjects with cytogenetically visible duplications of 15q, 2 with epilepsy and 18 age-matched normal controls were processed, yielding high-quality genotype data in all cases. The genotype and CNV data are provided via the ATP informatics portal as a resource for the autism research community. Autism Res 2011, 4: 89-97. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Lionel, Anath C.; Scherer, Stephen W.] Univ Toronto, McLaughlin Ctr, Toronto, ON M5G 1L7, Canada. [Lionel, Anath C.; Scherer, Stephen W.] Univ Toronto, Dept Mol Genet, Toronto, ON M5G 1L7, Canada. [Wintle, Richard F.; Lionel, Anath C.; Hu, Pingzhao; Pinto, Dalila; Thiruvahindrapduram, Bhooma; Wei, John; Marshall, Christian R.; Scherer, Stephen W.] Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1X8, Canada. [Ginsberg, Stephen D.] NYU, Langone Med Ctr, Ctr Dementia Res, Nathan Kline Inst, Orangeburg, NY USA. [Ginsberg, Stephen D.] NYU, Langone Med Ctr, Dept Psychiat, Orangeburg, NY USA. [Ginsberg, Stephen D.] NYU, Langone Med Ctr, Dept Physiol & Neurosci, Orangeburg, NY USA. [Pickett, Jane] Autism Speaks, Autism Tissue Program, Los Angeles, CA USA. [Cook, Edwin H.] Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60612 USA. RP Scherer, SW (reprint author), Univ Toronto, McLaughlin Ctr, Room 14-701,Toronto Med Discovery Tower,101 Coll, Toronto, ON M5G 1L7, Canada. EM stephen.scherer@sickkids.ca RI Howe, Jennifer/I-9013-2012; Scherer, Stephen /B-3785-2013 OI Scherer, Stephen /0000-0002-8326-1999 FU Autism Speaks; Autism Tissue Program Project [1299]; Genome Canada/Ontario Genomics Institute; Autism Genome Project; Centre for Applied Genomics; Netherlands Organization for Scientific Research [Rubicon 825.06.031]; NIH [HD057564, MH085208, MH086385]; U.S. Public Health Service [R24-MH068855]; Royal Netherlands Academy of Arts and Sciences [TMF/DA/5801]; PHS [R24-MH 068855]; Human Brain and Spinal Fluid Resource Center at UCLA; McLaughlin Centre; Canadian Institute for Advanced Research; Canada Foundation for Innovation; Ontario Ministry of Research and Innovation; Hospital for Sick Children (Sick Kids) Foundation FX Grant sponsors: Autism Speaks; Autism Tissue Program Project; Grant number: #1299; Grant sponsors: Genome Canada/Ontario Genomics Institute; Autism Genome Project; The Centre for Applied Genomics; Netherlands Organization for Scientific Research; Grant number: Rubicon 825.06.031; Grant sponsor: NIH; Grant numbers: HD057564; MH085208; MH086385; Grant sponsor: U.S. Public Health Service; Grant number: R24-MH068855; Grant sponsor: Royal Netherlands Academy of Arts and Sciences; Grant number: TMF/DA/5801.We thank the families of the donors and recognize their contributions to autism research at a time of great personal sorrow. We are grateful to Richard Pickett, ATP portal architect, Clara Lajonchere, VP Clinical Programs at Autism Speaks, Ellen Xiu, The Autism Tissue Program and the Genomics Committee of the Autism Genome Project for their assistance and enthusiasm. The work described here is Project #1299 of the Autism Tissue Program, "Autism Genome Project brain tissue geno-typing initiative", funded by Autism Speaks. Tissues were provided by the Harvard Brain Tissue Resource Center, which is supported in part by PHS grant number R24-MH 068855, and by the Human Brain and Spinal Fluid Resource Center at UCLA. We are grateful to George Tejada, Louis Fernandes, James Riehl and Wallace Tourtellotte for their assistance with these samples, and to Carol Ann Ryan for DNA preparation. SAGE control genotype data (Accession: phs000092.v1.p1) were obtained from NCBI dbGAP. The authors wish to acknowledge the Bioinformatics group and Microarray Facility of The Centre for Applied Genomics (The Hospital for Sick Children, Toronto, Canada) for excellent technical assistance and support. The Centre for Applied Genomics is supported by Genome Canada/Ontario Genomics Institute, the McLaughlin Centre, the Canadian Institute for Advanced Research, the Canada Foundation for Innovation, the Ontario Ministry of Research and Innovation and The Hospital for Sick Children (Sick Kids) Foundation. D.P. is supported by the Royal Netherlands Academy of Arts and Sciences (TMF/DA/5801) and the Netherland Organization for Scientific Research (Rubicon 825.06.031). S.D.G. is supported by NIH grants HD057564, MH085208, and MH086385. S.W.S. is the GlaxoSmithKline-CIHR Pathfinder Chair in Genetics and Genomics at Sick Kids and the University of Toronto. CR Altar CA, 2009, NEUROPSYCHOPHARMACOL, V34, P18, DOI 10.1038/npp.2008.172 Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005 Anney R, 2010, HUM MOL GENET, V19, P4072, DOI 10.1093/hmg/ddq307 Basu SN, 2009, NUCLEIC ACIDS RES, V37, pD832, DOI 10.1093/nar/gkn835 Bierut LJ, 2010, P NATL ACAD SCI USA, V107, P5082, DOI 10.1073/pnas.0911109107 Bradley WEC, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009401 Brimacombe MB, 2007, J AUTISM DEV DISORD, V37, P574, DOI 10.1007/s10803-006-0188-9 Ching MSL, 2010, AM J MED GENET B, V153B, P937, DOI 10.1002/ajmg.b.31063 Colella S, 2007, NUCLEIC ACIDS RES, V35, P2013, DOI 10.1093/nar/gkm076 Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458 Dellinger AE, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq040 Elia J., 2009, MOL PSYCHIATR, V15, P637 GINSBERG SD, 2009, ENCY NEUROSCIENCE, V5, P835 Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953 Haroutunian V, 2007, BRAIN PATHOL, V17, P412, DOI 10.1111/j.1750-3639.2007.00097.x Gibbs RA, 2003, NATURE, V426, P789, DOI 10.1038/nature02168 Iwamoto K, 2007, J NEUROSCI METH, V165, P104, DOI 10.1016/j.jneumeth.2007.05.029 Korn JM, 2008, NAT GENET, V40, P1253, DOI 10.1038/ng.237 Krawczak M, 2006, COMMUNITY GENET, V9, P55, DOI 10.1159/000090694 Lin M, 2004, BIOINFORMATICS, V20, P1233, DOI 10.1093/bioinformatics/bth069 Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 Martin CL, 2007, AM J MED GENET B, V144B, P869, DOI 10.1002/ajmg.b.30530 Palmieri L, 2010, MOL PSYCHIATR, V15, P38, DOI 10.1038/mp.2008.63 Pinto D, 2007, HUM MOL GENET, V16, pR168, DOI 10.1093/hmg/ddm241 Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 Piotrowski A, 2008, HUM MUTAT, V29, P1118, DOI 10.1002/humu.20815 Pritchard JK, 2000, GENETICS, V155, P945 Ruff ME, 2008, J NEUROSCI METH, V173, P315, DOI 10.1016/j.jneumeth.2008.06.023 Rutka JT, 2009, J NEURO-ONCOL, V92, P261, DOI 10.1007/s11060-009-9829-0 Scherer SW, 2007, NAT GENET, V39, pS7, DOI 10.1038/ng2093 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 Stewart AFR, 2009, J AM COLL CARDIOL, V53, P1471, DOI 10.1016/j.jacc.2008.12.051 Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 Wang K, 2007, GENOME RES, V17, P1665, DOI 10.1101/gr.6861907 Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Wegiel J, 2010, ACTA NEUROPATHOL, V119, P755, DOI 10.1007/s00401-010-0655-4 Xu B, 2009, P NATL ACAD SCI USA, V106, P16746, DOI 10.1073/pnas.0908584106 Xu Jie, 2004, Current Genomics, V5, P347, DOI 10.2174/1389202043349246 Zhang D, 2009, MOL PSYCHIATR, V14, P376, DOI 10.1038/mp.2008.144 NR 39 TC 10 Z9 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2011 VL 4 IS 2 BP 89 EP 97 DI 10.1002/aur.173 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 756GL UT WOS:000289999600001 PM 21254448 ER PT J AU Mathewson, KJ Drmic, IE Jetha, MK Bryson, SE Goldberg, JO Hall, GB Santesso, DL Segalowitz, SJ Schmidt, LA AF Mathewson, Karen J. Drmic, Irene E. Jetha, Michelle K. Bryson, Susan E. Goldberg, Joel O. Hall, Geoffrey B. Santesso, Diane L. Segalowitz, Sidney J. Schmidt, Louis A. TI Behavioral and Cardiac Responses to Emotional Stroop in Adults with Autism Spectrum Disorders: Influence of Medication SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders (ASD); heart period; respiratory sinus arrhythmia (RSA); Stroop task ID HEART-RATE-VARIABILITY; RESPIRATORY SINUS ARRHYTHMIA; BODY-MASS INDEX; ANTIPSYCHOTIC-DRUGS; NEUROVISCERAL INTEGRATION; INDIVIDUAL-DIFFERENCES; AUTONOMIC RESPONSE; RATE REACTIVITY; ATTENTION; CHILDREN AB Researchers have recently hypothesized that autism spectrum disorders (ASD) may be partly characterized by physiological over-arousal. One way to assess physiological arousal is through autonomic measures. Here heart period (HP) and parasympathetic activity measured by respiratory sinus arrhythmia (RSA) were examined in adults with ASD and matched controls at rest and during performance of an emotional Stroop task. Resting HP and RSA were lower in adults with ASD than in matched controls, consistent with hypothesized over-arousal in ASD. However, dividing the ASD group on the basis of antipsychotic medication usage revealed that group differences in autonomic arousal may be related to the effects of these medications or their correlates. Autonomic adjustments for Stroop performance were comparable across groups, but in the control group, larger RSA reductions were correlated with faster responding (i.e., better performance). This relation was reversed in the unmedicated ASD group and absent in the medicated ASD group. Findings highlight the importance of considering medication status in the recently burgeoning area of psychophysiological studies of autism. Autism Res 2011, 4: 98-108. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Mathewson, Karen J.; Jetha, Michelle K.; Schmidt, Louis A.] McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON L8S 4K1, Canada. [Drmic, Irene E.; Goldberg, Joel O.] York Univ, Dept Psychol, Toronto, ON M3J 2R7, Canada. [Bryson, Susan E.] IWK Hlth Ctr, Dept Pediat, Halifax, NS, Canada. [Bryson, Susan E.] IWK Hlth Ctr, Dept Psychol, Halifax, NS, Canada. [Bryson, Susan E.] Dalhousie Univ, Halifax, NS, Canada. [Goldberg, Joel O.; Hall, Geoffrey B.] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8S 4K1, Canada. [Santesso, Diane L.; Segalowitz, Sidney J.] Brock Univ, Dept Psychol, St Catharines, ON L2S 3A1, Canada. RP Mathewson, KJ (reprint author), McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON L8S 4K1, Canada. EM mathewkj@mcmaster.ca; schmidtl@mcmaster.ca FU Lawson Foundation; National Alliance for Autism Research (NAAR); Natural Sciences and Engineering Research Council of Canada (NSERC); Community Social and Vocational Rehabilitation (CVSR) Foundation; Social Sciences and Humanities Research Council of Canada (SSHRC) FX Grant sponsors: Lawson Foundation Post-doctoral Fellowship; National Alliance for Autism Research (NAAR) Pre-doctoral Fellowship; Natural Sciences and Engineering Research Council of Canada (NSERC) Pre-doctoral Fellowship; Community Social and Vocational Rehabilitation (CVSR) Foundation; Social Sciences and Humanities Research Council of Canada (SSHRC); NSERC Operating Grants. CR Allen JJB, 2007, BIOL PSYCHOL, V74, P243, DOI 10.1016/j.biopsycho.2006.08.005 Althaus M, 1999, BIOL PSYCHIAT, V46, P799, DOI 10.1016/S0006-3223(98)00374-6 Althaus M, 2004, PSYCHOPHYSIOLOGY, V41, P893, DOI 10.1111/j.1469-8986.2004.00252.x American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Antelmi I, 2004, AM J CARDIOL, V93, P381, DOI 10.1016/j.amjcard.2003.09.065 Bal E, 2010, J AUTISM DEV DISORD, V40, P358, DOI 10.1007/s10803-009-0884-3 Beauchaine T, 2001, DEV PSYCHOPATHOL, V13, P183, DOI 10.1017/S0954579401002012 Beck A. T., 1990, MANUAL BECK ANXIETY BENARROCH EE, 1993, MAYO CLIN PROC, V68, P988 Benton A.L., 1994, CONTRIBUTIONS NEUROP BERNIER L, 2005, J AUTISM DEV DISORD, V35, P575 BERNTSON GG, 1991, PSYCHOL REV, V98, P459, DOI 10.1037/0033-295X.98.4.459 BERNTSON GG, 1994, PSYCHOPHYSIOLOGY, V31, P599, DOI 10.1111/j.1469-8986.1994.tb02352.x Berntson GG, 1998, PSYCHOPHYSIOLOGY, V35, P127, DOI 10.1017/S0048577298001541 Boutcher YN, 2006, BIOL PSYCHOL, V73, P235, DOI 10.1016/j.biopsycho.2006.04.005 BROWN TG, 1988, PSYCHOPHYSIOLOGY, V25, P532, DOI 10.1111/j.1469-8986.1988.tb01888.x Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002 Buckley NA, 2000, DRUG SAFETY, V23, P215, DOI 10.2165/00002018-200023030-00004 Byrne EA, 1996, J APPL PHYSIOL, V81, P743 CACIOPPO JT, 1994, PSYCHOPHYSIOLOGY, V31, P412, DOI 10.1111/j.1469-8986.1994.tb02449.x Critchley HD, 2005, NEUROIMAGE, V24, P751, DOI 10.1016/j.neuroimage.2004.10.013 Critchley HD, 2000, J PHYSIOL-LONDON, V523, P259, DOI 10.1111/j.1469-7793.2000.t01-1-00259.x Dalton KM, 2005, J COGNITIVE NEUROSCI, V17, P969, DOI 10.1162/0898929054021094 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488 Denver JW, 2007, BIOL PSYCHOL, V74, P286, DOI 10.1016/j.biopsycho.2005.09.005 EKMAN A, 1976, PICTURES FACIAL AFFE Fabes RA, 1997, J PERS SOC PSYCHOL, V73, P1107, DOI 10.1037/0022-3514.73.5.1107 Gaigg SB, 2007, NEUROPSYCHOLOGIA, V45, P2125, DOI 10.1016/j.neuropsychologia.2007.01.012 Gianaros PJ, 2008, J NEUROSCI, V28, P990, DOI 10.1523/JNEUROSCI.3606-07.2008 Groden J., 1994, BEHAV ISSUES AUTISM, P178 Groden J., 2005, FOCUS AUTISM OTHER D, V20, P244, DOI DOI 10.1177/10883576050200040601 Hamer M, 2007, PSYCHOSOM MED, V69, P660, DOI 10.1097/PSY.0b013e318148c4c0 Hansen AL, 2003, INT J PSYCHOPHYSIOL, V48, P263, DOI 10.1016/S0167-8760(03)00073-4 Hill E, 2004, J AUTISM DEV DISORD, V34, P229, DOI 10.1023/B:JADD.0000022613.41399.14 Hofmann S. G., 2006, FOCUS AUTISM OTHER D, V21, P100, DOI DOI 10.1177/10883576060210020101 Hubert BE, 2009, AUTISM, V13, P9, DOI 10.1177/1362361308091649 Jansen LMC, 2006, J AUTISM DEV DISORD, V36, P891, DOI 10.1007/s10803-006-0124-z Johnsen BH, 2003, J ANXIETY DISORD, V17, P75, DOI 10.1016/S0887-6185(02)00178-0 KORKUSHKO OV, 1991, J AUTONOM NERV SYST, V32, P191, DOI 10.1016/0165-1838(91)90113-H LEVIN HS, 1975, J PSYCHOL, V91, P223 LEVY MN, 1990, ANN NY ACAD SCI, V601, P209, DOI 10.1111/j.1749-6632.1990.tb37302.x LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 MALIK M, 1993, AM J CARDIOL, V72, P821, DOI 10.1016/0002-9149(93)91070-X Mathewson KJ, 2010, INT J PSYCHOPHYSIOL, V76, P123, DOI 10.1016/j.ijpsycho.2010.02.007 Ming X, 2005, BRAIN DEV-JPN, V27, P509, DOI 10.1016/j.braindev.2005.01.003 PORGES SW, 1992, ATTENTION AND INFORMATION PROCESSING IN INFANTS AND ADULTS, P201 Porges SW, 2007, BIOL PSYCHOL, V74, P116, DOI 10.1016/j.biopsycho.2006.06.009 Prior M, 1998, AUTISM PERVASIVE DEV, P64 Ray WA, 2009, NEW ENGL J MED, V360, P225, DOI 10.1056/NEJMoa0806994 Ray WA, 2004, CLIN PHARMACOL THER, V75, P234, DOI 10.1016/j.clpt.2003.09.019 ROELOFSE JA, 1994, J ORAL MAXIL SURG, V52, P247, DOI 10.1016/0278-2391(94)90293-3 Roid G. H., 2003, STANFORD BINET INTEL Routledge FS, 2010, CAN J CARDIOL, V26, P303 Silke B, 2002, J PSYCHOPHARMACOL, V16, P355 South M, 2008, J INT NEUROPSYCH SOC, V14, P42, DOI 10.1017/S1355617708080107 Thayer JF, 2009, ANN BEHAV MED, V37, P141, DOI 10.1007/s12160-009-9101-z Thayer JF, 2000, J AFFECT DISORDERS, V61, P201, DOI 10.1016/S0165-0327(00)00338-4 Toichi M, 2003, J AUTISM DEV DISORD, V33, P417, DOI 10.1023/A:1025062812374 van Honk J, 1998, PSYCHONEUROENDOCRINO, V23, P741, DOI 10.1016/S0306-4530(98)00047-X Williams JMG, 1996, PSYCHOL BULL, V120, P3, DOI 10.1037/0033-2909.120.1.3 NR 62 TC 6 Z9 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2011 VL 4 IS 2 BP 98 EP 108 DI 10.1002/aur.176 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 756GL UT WOS:000289999600002 PM 21360828 ER PT J AU Solomon, M Smith, AC Frank, MJ Ly, S Carter, CS AF Solomon, Marjorie Smith, Anne C. Frank, Michael J. Ly, Stanford Carter, Cameron S. TI Probabilistic Reinforcement Learning in Adults with Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; probabilistic; reinforcement learning; basal ganglia; orbito-frontal cortex; computational model ID STIMULUS OVER-SELECTIVITY; HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; DECISION-MAKING; BEHAVIORAL-EXPERIMENTS; ORBITOFRONTAL CORTEX; EXECUTIVE FUNCTIONS; BASAL GANGLIA; IMPLICIT; CHILDREN AB Background: Autism spectrum disorders (ASDs) can be conceptualized as disorders of learning, however there have been few experimental studies taking this perspective. Methods: We examined the probabilistic reinforcement learning performance of 28 adults with ASDs and 30 typically developing adults on a task requiring learning relationships between three stimulus pairs consisting of Japanese characters with feedback that was valid with different probabilities (80%, 70%, and 60%). Both univariate and Bayesian state space data analytic methods were employed. Hypotheses were based on the extant literature as well as on neurobiological and computational models of reinforcement learning. Results: Both groups learned the task after training. However, there were group differences in early learning in the first task block where individuals with ASDs acquired the most frequently accurately reinforced stimulus pair (80%) comparably to typically developing individuals; exhibited poorer acquisition of the less frequently reinforced 70% pair as assessed by state space learning curves; and outperformed typically developing individuals on the near chance (60%) pair. Individuals with ASDs also demonstrated deficits in using positive feedback to exploit rewarded choices. Conclusions: Results support the contention that individuals with ASDs are slower learners. Based on neurobiology and on the results of computational modeling, one interpretation of this pattern of findings is that impairments are related to deficits in flexible updating of reinforcement history as mediated by the orbito-frontal cortex, with spared functioning of the basal ganglia. This hypothesis about the pathophysiology of learning in ASDs can be tested using functional magnetic resonance imaging. Autism Res 2011, 4: 109-120. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Solomon, Marjorie; Ly, Stanford; Carter, Cameron S.] Univ Calif Davis, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA. [Solomon, Marjorie] Univ Calif Davis, MIND Inst, UC Davis Hlth Syst, Sacramento, CA 95817 USA. [Solomon, Marjorie; Carter, Cameron S.] Univ Calif Davis, UC Davis Imaging Res Ctr, Sacramento, CA 95817 USA. [Smith, Anne C.] Univ Calif Davis, Dept Anesthesiol, Sacramento, CA 95817 USA. [Frank, Michael J.] Brown Univ, Dept Cognit & Linguist Sci, Providence, RI 02912 USA. [Frank, Michael J.] Brown Univ, Dept Psychol, Providence, RI 02912 USA. RP Solomon, M (reprint author), Univ Calif Davis, MIND Inst, UC Davis Hlth Syst, 2825 50th St, Sacramento, CA 95817 USA. EM marjorie.solomon@ucdmc.ucdavis.edu FU Autism Speaks; National Institute of Mental Health [1-K-08 MH074967-01, R-01 071847]; National Alliance for Research in Schizophrenia and Affective Disorders (NARSAD) FX The authors thank the adults who participated in this study and their family members. During this study, Dr. Solomon was supported by an Autism Speaks Pilot Award, a K08 Award from the National Institute of Mental Health (1-K-08 MH074967-01) and National Alliance for Research in Schizophrenia and Affective Disorders (NARSAD-Atherton Investigator). Dr. Anne Smith is supported by National Institute of Mental Health (R-01 071847). The authors report no financial conflicts of interest. CR Aizenstein HJ, 2004, CEREB CORTEX, V14, P199, DOI 10.1093/cercor/bhg119 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002 Balleine BW, 1998, NEUROPHARMACOLOGY, V37, P407, DOI 10.1016/S0028-3908(98)00033-1 Barch DM, 2004, NEUROPSYCHOLOGY, V18, P477, DOI 10.1037/0894-4105.18.3.477 Barnes KA, 2008, NEUROPSYCHOLOGY, V22, P563, DOI 10.1037/0894-4105.22.5.563 Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 BOTT L, 2006, Q J EXPT PSYCHOL, V59 Bowler DA, 2008, NEUROPSYCHOLOGIA, V46, P993, DOI 10.1016/j.neuropsychologia.2007.12.004 Brown J, 2010, Q J EXP PSYCHOL, V63, P1789, DOI 10.1080/17470210903536910 Brown JW, 2004, NEURAL NETWORKS, V17, P471, DOI 10.1016/j.neunet.2003.08.006 Carter CS, 2008, BIOL PSYCHIAT, V64, P842, DOI 10.1016/j.biopsych.2008.06.014 Chapman JP, 1973, DISORDERED THOUGHT S Chen F, 2005, MED HYPOTHESES, V65, P195, DOI 10.1016/j.mehy.2005.02.022 CLEEREMANS A, 1991, J EXP PSYCHOL GEN, V120, P235, DOI 10.1037/0096-3445.120.3.235 Curran T, 2001, TRENDS COGN SCI, V5, P503, DOI 10.1016/S1364-6613(00)01791-5 DAW ND, 2005, NAT NEUROSCI, V8, P1074 Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370 Doll BB, 2009, BRAIN RES, V1299, P74, DOI 10.1016/j.brainres.2009.07.007 ERNST M, 2009, YOUNG ADULT MENTAL H, P19 Fecteau S, 2006, BEHAV NEUROL, V17, P159 Frank MJ, 2006, PSYCHOL SCI, V17, P700, DOI 10.1111/j.1467-9280.2006.01769.x Frank MJ, 2005, MEM COGNITION, V33, P742, DOI 10.3758/BF03195340 Frank MJ, 2006, PSYCHOL REV, V113, P300, DOI 10.1037/0033-295X.113.2.300 Frank MJ, 2004, SCIENCE, V306, P1940, DOI 10.1126/science.1102941 Frank MJ, 2007, P NATL ACAD SCI USA, V104, P16311, DOI 10.1073/pnas.0706111104 Gordon B., 2007, FOCUS AUTISM OTHER D, V22, P14, DOI DOI 10.1177/10883576070220010201 Graybiel AM, 2008, ANNU REV NEUROSCI, V31, P359, DOI 10.1146/annurev.neuro.29.051605.112851 Hardan AY, 2003, J CHILD NEUROL, V18, P317, DOI 10.1177/08830738030180050801 Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003 HOBSON RP, 1996, AUTISM DEV MIND Howlin P, 2003, J AUTISM DEV DISORD, V33, P3, DOI 10.1023/A:1022270118899 Hughes C, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P255 Jog MS, 1999, SCIENCE, V286, P1745, DOI 10.1126/science.286.5445.1745 Johnson SA, 2006, J INT NEUROPSYCH SOC, V12, P668, DOI 10.1017/S1355617706060802 Juckel G, 2006, NEUROIMAGE, V29, P409, DOI 10.1016/j.neuroimage.2005.07.051 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kapur N, 1996, BRAIN, V119, P1775, DOI 10.1093/brain/119.5.1775 Kitagawa G., 1996, SMOOTHNESS PRIORS AN KLINGER IG, 2001, DEV PSYCHOPATHOL, V13, P111 KLINGER LG, 2010, NEW DEV AUTISM FUTUR Knight RA, 2001, J ABNORM PSYCHOL, V110, P15, DOI 10.1037/0021-843X.110.1.15 Knowlton BJ, 1996, SCIENCE, V273, P1399, DOI 10.1126/science.273.5280.1399 KOEGEL RL, 1978, J ABNORM PSYCHOL, V87, P563, DOI 10.1037/0021-843X.87.5.563 Kumaran D, 2009, NEURON, V63, P889, DOI 10.1016/j.neuron.2009.07.030 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 LOVAAS OI, 1979, PSYCHOL BULL, V86, P1236, DOI 10.1037//0033-2909.86.6.1236 Loveland KA, 2008, NEUROPSYCHOLOGIA, V46, P49, DOI 10.1016/j.neuropsychologia.2007.08.017 Luna B, 2002, NEUROLOGY, V59, P834 Lunn DJ, 2000, STAT COMPUT, V10, P325, DOI 10.1023/A:1008929526011 Macintosh KE, 2004, J CHILD PSYCHOL PSYC, V45, P421, DOI 10.1111/j.1469-7610.2004.00234.x Minassian A, 2007, J AUTISM DEV DISORD, V37, P1279, DOI 10.1007/s10803-006-0278-8 Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303 Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945 Molesworth CJ, 2005, J CHILD PSYCHOL PSYC, V46, P661, DOI 10.1111/j.1469-7610.2004.00383.x Mostofsky SH, 2000, J INT NEUROPSYCH SOC, V6, P752, DOI 10.1017/S1355617700677020 Murphy K., 2005, MATBUGS NATICK M, 2000, MATH WORKS MATLAB MA National Research Council, 2001, ED CHILDR AUT NEMETH D, 2010, PLOS ONE, V5, P1 Nyden A, 2000, EUR CHILD ADOLES PSY, V9, P180 Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110 Ozonoff S., 2000, ASPERGER SYNDROME, P24 Pennington B. F., 2002, DEV PSYCHOPATHOLOGY Pennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.x Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613 Reber PJ, 1998, J COGNITIVE NEUROSCI, V10, P248, DOI 10.1162/089892998562681 REBER PJ, 1967, J VERB LEARN VERB BE, V6, P855 Rolls ET, 1999, NEUROCASE, V5, P301, DOI 10.1080/13554799908411984 Ruble LA, 2002, AUTISM, V6, P365, DOI 10.1177/1362361302006004004 Schoenbaum G, 2005, NEURON, V47, P633, DOI 10.1016/j.neuron.2005.07.018 Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331 Schultz W, 1998, J NEUROPHYSIOL, V80, P1 Scott-Van Zeeland AA, 2010, AUTISM RES, V3, P53, DOI 10.1002/aur.122 Singer AC, 2009, NEURON, V64, P910, DOI 10.1016/j.neuron.2009.11.016 Smith AC, 2004, J NEUROSCI, V24, P447, DOI 10.1523/JNEUROSCI.2908-03.2004 Smith AC, 2007, J NEUROPHYSIOL, V97, P2516, DOI 10.1152/jn.00946.2006 Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019 Solomon M, 2008, J AUTISM DEV DISORD, V38, P1767, DOI 10.1007/s10803-008-0567-5 Soulieres I., 2010, Q J EXPT PSYCHOL, V64, P311 Sutton R. S., 1998, REINFORCEMENT LEARNI Szatmari P, 2003, J CHILD PSYCHOL PSYC, V44, P520, DOI 10.1111/1469-7610.00141 Travers BG, 2010, AUTISM RES, V3, P68, DOI 10.1002/aur.123 Vladusich T., 2010, AUTISM RES, V3, P1 Walenski M, 2008, J AUTISM DEV DISORD, V38, P1395, DOI 10.1007/s10803-007-0513-y Waltz JA, 2007, BIOL PSYCHIAT, V62, P756, DOI 10.1016/j.biopsych.2006.09.042 Wechsler D, 1999, WECHSLER ABBREVIATED NR 88 TC 18 Z9 18 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2011 VL 4 IS 2 BP 109 EP 120 DI 10.1002/aur.177 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 756GL UT WOS:000289999600003 PM 21425243 ER PT J AU Mandy, W Charman, T Gilmour, J Skuse, D AF Mandy, William Charman, Tony Gilmour, Jane Skuse, David TI Toward Specifying Pervasive Developmental Disorder-Not Otherwise Specified SO AUTISM RESEARCH LA English DT Article DE pervasive developmental disorder not otherwise specified (PDD-NOS); Autistic disorder; Asperger's disorder; autism spectrum disorder; diagnostic and statistical manual (DSM) ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS; PDD-NOS; PRESCHOOL-CHILDREN; ASPERGER-SYNDROME; DSM-IV; DIAGNOSTIC INTERVIEW; LESSER VARIANTS; CLASSIFICATION; POPULATION AB Pervasive developmental disorder-not otherwise specified (PDD-NOS) is the most common and least satisfactory of the PDD diagnoses. It is not formally operationalized, which limits its reliability and has hampered attempts to assess its validity. We aimed, first, to improve the reliability and replicability of PDD-NOS by operationalizing its DSM-IV-TR description and, second, to test its validity through comparison with autistic disorder (AD) and Asperger's disorder (AsD). In a sample of 256 young people (mean age = 9.1 years) we used Developmental, Diagnostic and Dimensional (3Di) algorithmic analysis to classify DSM-IV-TR AD (n = 97), AsD (n = 93) and PDD-NOS (n = 66). Groups were compared on independent measures of core PDD symptomatology, associated autistic features, and intelligence. Contrary to the assumption that PDD-NOS is heterogeneous, almost all (97%) of those with PDD-NOS had one distinct symptom pattern, namely impairments in social reciprocity and communication, without significant repetitive and stereotyped behaviors (RSB). Compared to AD and AsD, they had comparably severe but more circumscribed social communication difficulties, with fewer non-social features of autism, such as sensory, feeding and visuo-spatial problems. These individuals appear to have a distinct variant of autism that does not merely sit at the less severe end of the same continuum of symptoms. The current draft guidelines for DSM-V, which mandate the presence of RSBs for any PDD diagnosis, would exclude such people from the autistic spectrum. Autism Res 2011, 4: 121-131. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Mandy, William; Gilmour, Jane] UCL, Res Dept Clin Educ & Hlth Psychol, London WC1N 6BT, England. [Charman, Tony] Univ London, Inst Educ, Ctr Res Autism Educ, London WC1N 1AZ, England. [Skuse, David] UCL Inst Child Hlth, Behav & Brain Sci Unit, London, England. RP Mandy, W (reprint author), UCL, Res Dept Clin Educ & Hlth Psychol, Gower St, London WC1N 6BT, England. EM w.mandy@ucl.ac.uk RI Charman, Tony/A-2085-2014 OI Charman, Tony/0000-0003-1993-6549 CR Allen DA, 2001, EUR CHILD ADOLES PSY, V10, P67 *AM PSYCH ASS, 2010, 299 0 AUT DIS American Psychiatric Association, 2000, DIAGN STAT MAN MENT American Psychiatric Association, 1987, DIAGN STAT MAN MENT American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th American Psychiatric Association, 1980, DIAGN STAT MAN MENT Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Buitelaar JK, 1999, J AUTISM DEV DISORD, V29, P33, DOI 10.1023/A:1025966532041 Chakrabarti S, 2005, AM J PSYCHIAT, V162, P1133, DOI 10.1176/appi.ajp.162.6.1133 Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093 Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524 de Bruin EI, 2006, J ABNORM CHILD PSYCH, V34, P263, DOI 10.1007/s10802-005-9018-3 de Bruin EI, 2007, J AUTISM DEV DISORD, V37, P877, DOI 10.1007/s10803-006-0215-x de Bruin EI, 2006, DEV MED CHILD NEUROL, V48, P962, DOI 10.1017/S0012162206002118 Dunn L. M., 1997, BRIT PICTURE VOCABUL, V2nd Frith U, 2004, J CHILD PSYCHOL PSYC, V45, P672, DOI 10.1111/j.1469-7610.2004.00262.x Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079 Gadow KD, 2004, J AUTISM DEV DISORD, V34, P379, DOI 10.1023/B:JADD.0000037415.21458.93 GOODMAN R, 1989, J AUTISM DEV DISORD, V19, P409, DOI 10.1007/BF02212939 Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 Jensen VK, 1997, CLIN PEDIATR, V36, P555, DOI 10.1177/000992289703601001 Kendell R, 2003, AM J PSYCHIAT, V160, P4, DOI 10.1176/appi.ajp.160.1.4 Koyama T, 2008, PSYCHIAT CLIN NEUROS, V62, P691, DOI 10.1111/j.1440-1819.2008.01871.x Koyama T, 2006, J AUTISM DEV DISORD, V36, P373, DOI 10.1007/s10803-006-0075-4 Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Luteijn EF, 2000, EUR CHILD ADOLES PSY, V9, P168 Mahoney WJ, 1998, J AM ACAD CHILD PSY, V37, P278, DOI 10.1097/00004583-199803000-00012 Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x Matson JL, 2009, DEV NEUROREHABIL, V12, P122, DOI 10.1080/17518420902936730 Matson JL, 2008, J AUTISM DEV DISORD, V38, P530, DOI 10.1007/s10803-007-0422-0 MAYES L, 1993, J AUTISM DEV DISORD, V23, P79, DOI 10.1007/BF01066420 Miller JN, 1997, J CHILD PSYCHOL PSYC, V38, P247 Njardvik U, 1999, J AUTISM DEV DISORD, V29, P287, DOI 10.1023/A:1022107318500 Paul R, 2004, J AUTISM DEV DISORD, V34, P223, DOI 10.1023/B:JADD.0000022612.18116.46 Pearson DA, 2006, CHILD NEUROPSYCHOL, V12, P321, DOI 10.1080/092970406006464847 Roeyers H, 1998, J LEARN DISABIL, V31, P565 Sanders JL, 2009, J AUTISM DEV DISORD, V39, P1560, DOI 10.1007/s10803-009-0798-0 Santosh PJ, 2009, EUR CHILD ADOLES PSY, V18, P521, DOI 10.1007/s00787-009-0004-0 Scheirs JGM, 2009, J AUTISM DEV DISORD, V39, P549, DOI 10.1007/s10803-008-0657-4 Serra M, 1995, EUR CHILD ADOLES PSY, V4, P259 Serra M, 2003, J AUTISM DEV DISORD, V33, P303, DOI 10.1023/A:1024458618172 Serra M, 2002, J CHILD PSYCHOL PSYC, V43, P885, DOI 10.1111/1469-7610.00104 Serra M, 1999, EUR CHILD ADOLES PSY, V8, P301 Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f Skuse D, 2004, J AM ACAD CHILD PSY, V43, P548, DOI 10.1097/00004583-200405000-00008 Spitzer RL, 2001, J NERV MENT DIS, V189, P351, DOI 10.1097/00005053-200106000-00002 Szatmari P, 2009, J CHILD PSYCHOL PSYC, V50, P1459, DOI 10.1111/j.1469-7610.2009.02123.x Szatmari P, 2000, CAN J PSYCHIAT, V45, P731 Szatmari P, 2000, AM J PSYCHIAT, V157, P1980, DOI 10.1176/appi.ajp.157.12.1980 Takeda T, 2007, PSYCHIAT CLIN NEUROS, V61, P684, DOI 10.1111/j.1440-1819.2007.01740.x Tanguay PE, 1998, J AM ACAD CHILD PSY, V37, P271, DOI 10.1097/00004583-199803000-00011 Towbin KE, 2005, HDB AUTISM PERVASIVE, P165 Verte S, 2006, AUTISM, V10, P266, DOI 10.1177/1362361306063299 Volkmar FR, 2000, J AUTISM DEV DISORD, V30, P74 Walker DR, 2004, J AM ACAD CHILD PSY, V43, P172, DOI 10.1097/01.chi.0000101375.03068.db Wechsler D., 1991, MANUAL WECHSLER INTE Wechsler D., 1999, MANUAL WECHSLER ABBR Wechsler D., 2003, MANUAL WECHSLER INTE, VFourth Weisbrot DM, 2005, J CHILD ADOL PSYCHOP, V15, P477, DOI 10.1089/cap.2005.15.477 World Health Organisation, 1993, INT CLASS DIS DIS 10 NR 63 TC 29 Z9 29 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2011 VL 4 IS 2 BP 121 EP 131 DI 10.1002/aur.178 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 756GL UT WOS:000289999600004 PM 21298812 ER PT J AU O'Hearn, K Lakusta, L Schroer, E Minshew, N Luna, B AF O'Hearn, Kirsten Lakusta, Laura Schroer, Elizabeth Minshew, Nancy Luna, Beatriz TI Deficits in Adults With Autism Spectrum Disorders When Processing Multiple Objects in Dynamic Scenes SO AUTISM RESEARCH LA English DT Article DE ASD; change detection; development; developmental disorder; people perception; social cognition ID SPATIAL WORKING-MEMORY; CHANGE BLINDNESS; NATURALISTIC SCENES; EXECUTIVE FUNCTION; JOINT ATTENTION; YOUNG-CHILDREN; EYE-DIRECTION; FACE; GAZE; PERCEPTION AB People with autism spectrum disorders (ASD) process visual information in a manner that is distinct from typically developing individuals. They may be less sensitive to people's goals and, more generally, focus on visual details instead of the entire scene. To examine these differences, people with and without ASD were asked to detect changes in dynamic scenes with multiple elements. Participants viewed a brief video of a person or an inanimate object (the "figure") moving from one object to another; after a delay, they reported whether a second video was the same or different. Possible changes included the figure, the object the figure was moving from, or the object the figure was moving toward (the "goal"). We hypothesized that individuals with ASD would be less sensitive to changes in scenes with people, particularly elements that might be the person's goal. Alternately, people with ASH might attend to fewer elements regardless of whether the scene included a person. Our results indicate that, like controls, people with ASD noticed a change in the "goal" object at the end of a person's movement more often than the object at the start. However, the group with ASD did not undergo the developmental improvement that was evident typically when detecting changes in both the start and end objects. This atypical development led to deficits in adults with ASD that were not specific to scenes with people or to "goals." Improvements in visual processing that underlie mature representation of scenes may not occur in ASD, suggesting that late developing brain processes are affected. Autism Res 2011, 4: 132-142. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [O'Hearn, Kirsten; Schroer, Elizabeth; Minshew, Nancy; Luna, Beatriz] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA. [Lakusta, Laura] Montclair State Univ, Dept Psychol, Montclair, NJ USA. [Minshew, Nancy] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA. RP O'Hearn, K (reprint author), Western Psychiat Inst & Clin, Lab Neurocognit Dev, Loeffler Bldg Off 112,121 Meyran Ave, Pittsburgh, PA 15213 USA. EM ohearnk@upmc.edu FU Autism Speaks [04593]; NIH [HD 055748]; NIMH [R01 MH067924, KO1 081191] FX This work was performed at the University of Pittsburgh and supported by Autism Speaks Grant 04593 to B.L., NIH HD 055748 to N.M., NIMH 5 R01 MH067924 to B.L., NIMH KO1 081191 to K.O.H. We are very grateful to the participants and their families, the staff at the CeFar (Now ACE) in Pittsburgh, and the Autism Speaks organization, as well as Catherine Wright for help on this manuscript. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002 Brosnan MJ, 2004, J CHILD PSYCHOL PSYC, V45, P459, DOI 10.1111/j.1469-7610.2004.00237.x Burack JA, 2009, J AUTISM DEV DISORD, V39, P471, DOI 10.1007/s10803-008-0647-6 Campbell R, 2006, DEV PSYCHOPATHOL, V18, P99, DOI 10.1017/S0954579406060068 Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189 Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018 De Jong MC, 2008, J AM ACAD CHILD PSY, V47, P443, DOI 10.1097/CHI.0b013e31816429a6 Deruelle C, 2008, BRAIN COGNITION, V66, P115, DOI 10.1016/j.bandc.2007.06.001 Dichter GS, 2007, NEUROIMAGE, V35, P1219, DOI 10.1016/j.neuroimage.2006.12.038 Fair DA, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000381 Falck-Ytter T, 2010, BIOL LETTERS, V6, P375, DOI 10.1098/rsbl.2009.0897 Fletcher-Watson S, 2008, J AUTISM DEV DISORD, V38, P1785, DOI 10.1007/s10803-008-0548-8 Fletcher-Watson S, 2009, DEVELOPMENTAL SCI, V12, P438, DOI 10.1111/j.1467-7687.2008.00784.x FLETCHERWATSON S, 2008, NEUROPSYCHOLOGIA, V47, P248 Fletcher-Watson S, 2006, BRIT J PSYCHOL, V97, P537, DOI 10.1348/000712606X114057 Freeth M, 2010, J AUTISM DEV DISORD, V40, P534, DOI 10.1007/s10803-009-0893-2 Freeth M, 2010, J EXP CHILD PSYCHOL, V105, P20, DOI 10.1016/j.jecp.2009.10.001 FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8 Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2 Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950 HERMERVAZQUEZ L, 2008, COGNITIVE PSYCHOL, V39, P3 Jemel B, 2006, J AUTISM DEV DISORD, V36, P91, DOI 10.1007/s10803-005-0050-5 Jolliffe T, 2001, Cogn Neuropsychiatry, V6, P193 Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Kleinbaum DG, 1988, APPL REGRESSION ANAL Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042 Leekam S, 1997, BRIT J DEV PSYCHOL, V15, P77 Leekam SR, 2000, DEV PSYCHOL, V36, P261, DOI 10.1037/0012-1649.36.2.261 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Loth E, 2008, AUTISM RES, V1, P179, DOI 10.1002/aur.19 Luna B, 2001, NEUROIMAGE, V13, P786, DOI 10.1006/nimg.2000.0743 Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030 Luna B, 2002, NEUROLOGY, V59, P834 Minshew N. J., 1996, PRINCIPLES CHILD NEU, P1713 Minshew NJ, 1999, NEUROLOGY, V52, P917 Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x Nakahachi T, 2008, PSYCHIAT RES, V159, P330, DOI 10.1016/j.psychres.2005.08.028 New JJ, 2010, NEUROPSYCHOLOGIA, V48, P51, DOI 10.1016/j.neuropsychologia.2009.08.008 O'Hearn K, 2010, NEUROPSYCHOLOGIA, V48, P3955, DOI 10.1016/j.neuropsychologia.2010.08.024 O'Riordan M, 2001, Q J EXP PSYCHOL-A, V54, P961, DOI 10.1080/02724980042000543 Pelphrey K, 2004, MENT RETARD DEV D R, V10, P259, DOI 10.1002/mrdd Pelphrey KA, 2005, BRAIN, V128, P1038, DOI 10.1093/brain/awh404 Perner J, 2008, Q J EXP PSYCHOL, V61, P76, DOI 10.1080/17470210701508756 Pierno AC, 2006, NEUROPSYCHOLOGIA, V44, P1483, DOI 10.1016/j.neuropsychologia.2005.11.013 Raznahan A, 2010, CEREB CORTEX, V20, P1332, DOI 10.1093/cercor/bhp198 Rensink RA, 2002, ANNU REV PSYCHOL, V53, P245, DOI 10.1146/annurev.psych.53.100901.135125 Ro T, 2001, PSYCHOL SCI, V12, P94, DOI 10.1111/1467-9280.00317 Rump KM, 2009, CHILD DEV, V80, P1434, DOI 10.1111/j.1467-8624.2009.01343.x Rutherford MD, 2006, J AUTISM DEV DISORD, V36, P983, DOI 10.1007/s10803-006-0136-8 Rutherford MD, 2008, J AUTISM DEV DISORD, V38, P1958, DOI 10.1007/s10803-008-0592-4 Sasson NJ, 2006, J AUTISM DEV DISORD, V36, P381, DOI 10.1007/s10803-006-0076-3 Scherf KS, 2010, FRONT HUM NEUROSCI, V4, DOI 10.3389/fnhum.2010.00026 Scherf KS, 2009, CHILD DEV, V80, P162, DOI 10.1111/j.1467-8624.2008.01252.x Scherf KS, 2008, AUTISM RES, V1, P114, DOI 10.1002/aur.17 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x Shore DI, 2006, DEVELOPMENTAL SCI, V9, P490, DOI 10.1111/j.1467-7687.2006.00516.x Simons DJ, 2000, PERCEPTION, V29, P1143, DOI 10.1068/p3104 Simons DJ, 2005, TRENDS COGN SCI, V9, P16, DOI 10.1016/j.tics.2004.11.006 Simons DJ, 1997, TRENDS COGN SCI, V1, P261, DOI 10.1016/S1364-6613(97)01080-2 Smith H, 2009, J CHILD PSYCHOL PSYC, V50, P300, DOI 10.1111/j.1469-7610.2008.01957.x Speer LL, 2007, AUTISM, V11, P265, DOI 10.1177/1362361307076925 Steele SD, 2007, J AUTISM DEV DISORD, V37, P605, DOI 10.1007/s10803-006-0202-2 TAGERFLUSBERG H, 1994, J AUTISM DEV DISORD, V24, P577, DOI 10.1007/BF02172139 Tuchman R, 2003, NEUROL CLIN, V21, P915, DOI 10.1016/S0733-8619(03)00011-2 Wallace S, 2006, PERCEPTION, V35, P1651, DOI 10.1068/p5442 Wechsler D, 1999, WECHSLER ABBREVIATED Williams DL, 2005, ARCH CLIN NEUROPSYCH, V20, P1, DOI 10.1016/j.acn.2002.08.001 NR 71 TC 6 Z9 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2011 VL 4 IS 2 BP 132 EP 142 DI 10.1002/aur.179 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 756GL UT WOS:000289999600005 PM 21254449 ER PT J AU Ingersoll, B Meyer, K Becker, MW AF Ingersoll, Brooke Meyer, Katherine Becker, Mark W. TI Increased Rates of Depressed Mood in Mothers of Children With ASD Associated With the Presence of the Broader Autism Phenotype SO AUTISM RESEARCH LA English DT Article DE broader autism phenotype; depressed mood; parenting stress ID SEROTONIN TRANSPORTER; SPECTRUM DISORDERS; PSYCHIATRIC-DISORDERS; PERSONALITY-TRAITS; BEHAVIOR PROBLEMS; FAMILY-HISTORY; STRESS; PARENTS; IMPACT; GENE AB This study examined the relationship between the broader autism phenotype (BAP) and depressed mood in mothers of children with and without autism spectrum disorders (ASD). One hundred and sixty-five mothers (71 with an ASD child and 94 with a non-ASD child) completed a survey of child autism severity (ASD mothers only), parenting stress, BAP, and depression. Mothers of children with ASD reported greater depressed mood, higher parenting stress, and more characteristics associated with the BAP than mothers of children without ASD. For mothers of children with ASD, the BAP uniquely predicted number of depressive symptoms after controlling for child autism severity and parenting stress. In the full sample, the relationship between group status and depressed mood was no longer significant after controlling for parenting stress and maternal BAP. These findings suggest that the higher rate of depression found in mothers of children with ASD may be attributed both to the increased stress of raising a child with ASD, as well as a greater number of autistic features in the mothers that may place them at higher risk for developing depression. Autism Res 2011, 4: 143-148. (C) 2010 International Society for Autism Research, Wiley Periodicals, Inc. C1 [Ingersoll, Brooke; Meyer, Katherine; Becker, Mark W.] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA. RP Ingersoll, B (reprint author), Michigan State Univ, Dept Psychol, 105B Psychol Bldg, E Lansing, MI 48824 USA. EM ingers19@msu.edu RI Ingersoll, Brooke/A-9117-2012 FU Autism Speaks [5020, 4726] FX Grant sponsor: Autism Speaks; Grant numbers: 5020; 4726. CR Baker BL, 2002, AM J MENT RETARD, V107, P433, DOI 10.1352/0895-8017(2002)107<0433:BPAPSI>2.0.CO;2 Baker-Ericzen MJ, 2005, RES PRACT PERS SEV D, V30, P194, DOI 10.2511/rpsd.30.4.194 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Battaglia M, 2005, ARCH GEN PSYCHIAT, V62, P85, DOI 10.1001/archpsyc.62.1.85 BEBKO JM, 1987, J AUTISM DEV DISORD, V17, P565, DOI 10.1007/BF01486971 Benson PR, 2006, J AUTISM DEV DISORD, V36, P685, DOI 10.1007/s10803-006-0112-3 Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004 BOUMA R, 1990, J CLIN PSYCHOL, V46, P722, DOI 10.1002/1097-4679(199011)46:6<722::AID-JCLP2270460605>3.0.CO;2-6 Brune CW, 2006, AM J PSYCHIAT, V163, P2148, DOI 10.1176/appi.ajp.163.12.2148 Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968 DeMyer M., 1979, PARENTS CHILDREN AUT Devlin B, 2005, MOL PSYCHIATR, V10, P1110, DOI 10.1038/sj.mp.4001724 DONENBERG G, 1993, J ABNORM CHILD PSYCH, V21, P179, DOI 10.1007/BF00911315 Dumas J. E., 1991, EXCEPTIONALITY, V2, P97, DOI [10.1080/09362839109524770, DOI 10.1080/09362839109524770] Duvall JA, 2007, AM J PSYCHIAT, V164, P656, DOI 10.1176/appi.ajp.164.4.656 Fombonne E, 2003, J AUTISM DEV DISORD, V33, P365, DOI 10.1023/A:1025054610557 GONDA X, 2001, EUROPEAN ARCH PSYCHI, V259, P106 Gosling SD, 2004, AM PSYCHOL, V59, P93, DOI 10.1037/0003-066X.59.2.93 Hastings RP, 2002, J INTELLECT DEV DIS, V27, P149, DOI 10.1080/1366825021000008657 Ingersoll B, 2011, RES AUTISM SPECT DIS, V5, P337, DOI 10.1016/j.rasd.2010.04.017 KOEGEL RL, 1992, J AUTISM DEV DISORD, V22, P205, DOI 10.1007/BF01058151 KRUG DA, 1980, AUTISM BEHAV CHECKLI Kunihira Y, 2006, J AUTISM DEV DISORD, V36, P553, DOI 10.1007/s10803-006-0094-1 Murphy M, 2000, PSYCHOL MED, V30, P1411, DOI 10.1017/S0033291799002949 Piven J, 1999, AM J PSYCHIAT, V156, P557 PIVEN J, 1991, J AM ACAD CHILD PSY, V30, P471, DOI 10.1097/00004583-199105000-00019 PIVEN J, 1994, PSYCHOL MED, V24, P783 Piven J, 1997, AM J PSYCHIAT, V154, P185 RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306 RODRIGUE JR, 1990, J CLIN CHILD PSYCHOL, V19, P371, DOI 10.1207/s15374424jccp1904_9 Rosenberg RE, 2009, ARCH PEDIAT ADOL MED, V163, P907, DOI 10.1001/archpediatrics.2009.98 STANTON JM, 2002, 13001 SYRAC U SCH IN Tordjman S, 2001, MOL PSYCHIATR, V6, P434, DOI 10.1038/sj.mp.4000873 NR 35 TC 10 Z9 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2011 VL 4 IS 2 BP 143 EP 148 DI 10.1002/aur.170 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 756GL UT WOS:000289999600006 PM 21480539 ER PT J AU White, SJ Coniston, D Rogers, R Frith, U AF White, Sarah J. Coniston, Devorah Rogers, Rosannagh Frith, Uta TI Developing the Frith-Happe Animations: A Quick and Objective Test of Theory of Mind for Adults with Autism SO AUTISM RESEARCH LA English DT Article DE autism; Theory of Mind; mentalizing; triangle animations; classification; test sensitivity ID HIGHER-FUNCTIONING AUTISM; ATTRIBUTION; PERCEPTION; MOVEMENT; CHILDREN; SPECTRUM; SCHIZOPHRENIA; INTENTION; COGNITION; PATTERNS AB It is now widely accepted that individuals with autism have a Theory of Mind (ToM) or mentalizing deficit. This has traditionally been assessed with false-belief tasks and, more recently, with silent geometric animations, an on-line ToM task. In adults with milder forms of autism standard false-belief tests, originally devised for children, often prove insensitive, while the Frith-Happe animations have had rather better success at capturing the on-line ToM deficit in this population. However, analysis of participants' verbal descriptions of these animations, which span scenarios from "Random" to "Goal-Directed" and "ToM," is time consuming and subjective. In this study, we developed and established the feasibility of an objective method of response through a series of multiple-choice questions. Sixteen adults with autism and 15 typically developing adults took part, matched for age and intelligence. The adults with autism were less accurate as a group at categorizing the Frith-Happe animations by the presence or absence of mental and physical interactions. Furthermore, they were less able to select the correct emotions that are typically attributed to the triangles in the mental state animations. This new objective method for assessing the understanding of the animations succeeded in being as sensitive as the original subjective method in detecting the mentalizing difficulties in autism, as well as being quicker and easier to administer and analyze. Autism Res 2011, 4: 149-154. (C) 2011 International Society for Autism Research, Wiley Periodicals, Inc. C1 [White, Sarah J.; Coniston, Devorah; Rogers, Rosannagh; Frith, Uta] UCL, Inst Cognit Neurosci, London WC1N 3AR, England. RP White, SJ (reprint author), UCL, Inst Cognit Neurosci, 17 Queen Sq, London WC1N 3AR, England. EM s.white@ucl.ac.uk RI White, Sarah/C-4084-2008 OI White, Sarah/0000-0001-6946-9155 FU Medical Research Council; Economic and Social Research Council; British Academy [PTA-037-27-0107, PDF/2009/213] FX Grant sponsors: Medical Research Council, and Economic and Social Research Council; British Academy; Grant numbers: PTA-037-27-0107; PDF/2009/213. CR Abell F, 2000, COGNITIVE DEV, V15, P1, DOI 10.1016/S0885-2014(00)00014-9 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 BERRY DS, 1993, ECOL PSYCHOL, V5, P237 Bird CM, 2004, BRAIN, V127, P914, DOI 10.1093/brain/awh108 Bowler D, 2000, AUTISM, V4, P147, DOI 10.1177/1362361300004002004 BOWLER DM, 1992, J CHILD PSYCHOL PSYC, V33, P877, DOI 10.1111/j.1469-7610.1992.tb01962.x Campbell R, 2006, DEV PSYCHOPATHOL, V18, P99, DOI 10.1017/S0954579406060068 CASTELLI F, 2002, BRAIN, V125, P1 CASTELLI F, 2000, NEUROIMAGE, V11, P157 Corden B, 2006, J COGNITIVE NEUROSCI, V18, P889, DOI 10.1162/jocn.2006.18.6.889 FLETCHER PC, 1995, COGNITION, V57, P109, DOI 10.1016/0010-0277(95)00692-R Heider F, 1944, AM J PSYCHOL, V57, P243, DOI 10.2307/1416950 Kana RK, 2009, SOC NEUROSCI-UK, V4, P135, DOI 10.1080/17470910802198510 Klein AM, 2009, Q J EXP PSYCHOL, V62, P1189, DOI 10.1080/17470210802384214 Klin A, 2006, BRAIN COGNITION, V61, P40, DOI 10.1016/j.bandc.2005.12.016 Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101 Knickmeyer R, 2006, HORM BEHAV, V49, P282, DOI 10.1016/j.yhbeh.2005.08.010 Koelkebeck K, 2010, SCHIZOPHR RES, V119, P115, DOI 10.1016/j.schres.2009.12.015 Lawrence K, 2007, COGNITION, V102, P84, DOI 10.1016/j.cognition.2005.12.003 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Luckett T, 2002, J AUTISM DEV DISORD, V32, P127, DOI 10.1023/A:1014844722931 Montgomery DE, 1999, BRIT J DEV PSYCHOL, V17, P245, DOI 10.1348/026151099165258 Moriguchi Y, 2006, NEUROIMAGE, V32, P1472, DOI 10.1016/j.neuroimage.2006.04.186 Moriguchi Y, 2007, PSYCHIAT CLIN NEUROS, V61, P355, DOI 10.1111/j.1440-1819.2007.01687.x OATLEY K, 1985, BRIT J SOC PSYCHOL, V24, P115 PERNER J, 1985, J EXP CHILD PSYCHOL, V39, P437, DOI 10.1016/0022-0965(85)90051-7 Perner J, 1989, Child Dev, V60, P688 RIME B, 1985, MOTIV EMOTION, V9, P241, DOI 10.1007/BF00991830 Rosenbaum RS, 2007, SCIENCE, V318, P1257, DOI 10.1126/science.1148763 Russell TA, 2006, SCHIZOPHR RES, V81, P101, DOI 10.1016/j.schres.2005.10.002 Salter G, 2008, AUTISM, V12, P349, DOI 10.1177/1362361308091654 Springer K, 1996, J NONVERBAL BEHAV, V20, P199, DOI 10.1007/BF02248673 Wechsler D, 1999, WECHSLER ADULT INTEL Wellman HM, 2004, CHILD DEV, V75, P523, DOI 10.1111/j.1467-8624.2004.00691.x Zwickel J, 2009, PSYCHON B REV, V16, P1089, DOI 10.3758/PBR.16.6.1089 Zwickel J, 2009, INT J SOC ROBOT, V1, P357, DOI 10.1007/s12369-009-0033-3 ZWICKEL J, 2010, SOCIAL COGN IN PRESS NR 38 TC 11 Z9 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2011 VL 4 IS 2 BP 149 EP 154 DI 10.1002/aur.174 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 756GL UT WOS:000289999600007 PM 21480540 ER PT J AU Cook, EH AF Cook, Edwin H., Jr. TI De Novo Autosomal Dominant Mutation in SYNGAP1 SO AUTISM RESEARCH LA English DT Editorial Material C1 Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60612 USA. RP Cook, EH (reprint author), Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60612 USA. EM ecook@psych.uic.edu CR HAMDAN FF, BIOL PSYCHIAT Hamdan FF, 2009, NEW ENGL J MED, V360, P599, DOI 10.1056/NEJMoa0805392 Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 NR 3 TC 0 Z9 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2011 VL 4 IS 2 BP 155 EP 156 DI 10.1002/aur.198 PG 2 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 756GL UT WOS:000289999600008 PM 21480541 ER PT J AU Minshew, N McFadden, K AF Minshew, Nancy McFadden, Kathyrn TI Commentary for Special Issue of Autism Research on Mouse Models in ASD: A Clinical Perspective SO AUTISM RESEARCH LA English DT Editorial Material C1 [Minshew, Nancy; McFadden, Kathyrn] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA. RP Minshew, N (reprint author), Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA. EM minshewnj@upmc.edu; mcfaddenka@upmc.edu NR 0 TC 1 Z9 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2011 VL 4 IS 1 SI SI BP 1 EP 4 DI 10.1002/aur.185 PG 4 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 729JP UT WOS:000287945900001 PM 21328567 ER PT J AU Ey, E Leblond, CS Bourgeron, T AF Ey, Elodie Leblond, Claire S. Bourgeron, Thomas TI Behavioral Profiles of Mouse Models for Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Review DE autism spectrum disorder; mouse model; synaptic pathway; mTOR/PI3K pathway; behavior ID FRAGILE-X-SYNDROME; SCAFFOLDING PROTEIN SHANK3; CPG-BINDING PROTEIN-2; COPY NUMBER VARIATION; HUMAN FMR1 TRANSGENE; MECP2 MUTANT MICE; RETT-SYNDROME; TUBEROUS-SCLEROSIS; ULTRASONIC VOCALIZATIONS; SOCIAL INTERACTIONS AB Autism spectrum disorders (ASD) are characterized by impairments in reciprocal social communication, and stereotyped verbal and nonverbal behaviors. In approximately 10-25% of the affected individuals, a genetic mutation associated with the condition can be identified. Recently, mutations altering synapse formation, cellular/synaptic growth rate and regulation of excitatory and inhibitory currents were identified in patients with intellectual disability, typical autism, Asperger syndrome or neurological syndromes associated with autistic traits. Following these genetic findings, mouse models carrying mutations similar to those identified in patients have been generated. These models offer the opportunity to investigate in vivo the physiological and behavioral consequences of the mutations. Here, we review the existing data on the phenotypes of mice carrying mutations in genes associated with ASD including neuroligin, neurexin and Shank mutant mice as well as the Fmr1, Mecp2, Ube3a, Nf1, Pten and Tsc1/Tsc2 mutant mice. The diversity and complexity of the phenotype of these mouse models reflect the broad range of phenotypes observed in patients with ASD. Remarkably, results from therapeutic approaches (e.g., modulation of gene expression, administration of pharmacological and nonpharmacological substances, enriched environment) are encouraging since some behavioral alterations could be reversed even when treatment was performed on adult mice. These ongoing studies should therefore increase our understanding of the biological alterations associated with ASD as well as the development of knowledge-based treatments. C1 [Ey, Elodie; Leblond, Claire S.; Bourgeron, Thomas] Inst Pasteur, CNRS, URA Genes Synapses & Cognit 2182, F-75015 Paris, France. [Bourgeron, Thomas] Univ Paris 07, Paris, France. [Bourgeron, Thomas] Fdn FondaMental French Natl Sci Fdn, Creteil, France. RP Ey, E (reprint author), Inst Pasteur, CNRS, URA Genes Synapses & Cognit 2182, 25 Rue Docteur Roux, F-75015 Paris, France. EM elodie@pasteur.fr CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Amir RE, 1999, NAT GENET, V23, P185 Bellini S., 2004, FOCUS AUTISM OTHER D, V19, P78, DOI DOI 10.1177/10883576040190020201 Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589 Berry R. J., 1981, S ZOOLOGICAL SOC LON, V47, P395 Blundell J, 2009, GENES BRAIN BEHAV, V8, P114, DOI 10.1111/j.1601-183X.2008.00455.x Blundell J, 2010, J NEUROSCI, V30, P2115, DOI 10.1523/JNEUROSCI.4517-09.2010 Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003 Bourin M, 2003, EUR J PHARMACOL, V463, P55, DOI 10.1016/S0014-2999(03)01274-3 Brennan PA, 2006, PHILOS T R SOC B, V361, P2061, DOI 10.1098/rstb.2006.1931 Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646 Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22 Chen RZ, 2001, NAT GENET, V27, P327, DOI 10.1038/85906 Collins AL, 2004, HUM MOL GENET, V13, P2679, DOI 10.1093/hmg/ddh282 Costa RM, 2001, NAT GENET, V27, P399, DOI 10.1038/86898 Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x Bernardet M, 2006, THESCIENTIFICWORLDJO, V6, P1164, DOI 10.1100/tsw.2006.220 Dahlhaus R, 2010, BEHAV BRAIN RES, V208, P96, DOI 10.1016/j.bbr.2009.11.019 DEFILIPPIS B, 2009, NEUROMETHODS, V44, P151 Durand CM, 2007, NAT GENET, V39, P25, DOI 10.1038/ng1933 Eadie BD, 2009, NEUROBIOL DIS, V36, P361, DOI 10.1016/j.nbd.2009.08.001 Ehninger D, 2008, NEURON, V60, P950, DOI 10.1016/j.neuron.2008.12.007 Ehninger D, 2011, BEHAV GENET, V41, P357, DOI 10.1007/s10519-010-9398-1 Ehninger D, 2009, J INTELL DISABIL RES, V53, P838, DOI 10.1111/j.1365-2788.2009.01208.x Ehninger D, 2008, NAT MED, V14, P843, DOI 10.1038/nm1788 Enard W, 2009, CELL, V137, P961, DOI 10.1016/j.cell.2009.03.041 Erbayat-Altay E, 2007, EPILEPSIA, V48, P1470, DOI 10.1111/j.1528-1167.2007.01110.x Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106 Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017 Fernandez T, 2008, AM J HUM GENET, V82, P1385, DOI 10.1016/j.ajhg.2008.04.021 Fernell E, 2010, RES DEV DISABIL, V31, P680, DOI 10.1016/j.ridd.2010.01.007 Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896 Fyffe SL, 2008, NEURON, V59, P947, DOI 10.1016/j.neuron.2008.07.030 Garber KB, 2008, EUR J HUM GENET, V16, P666, DOI 10.1038/ejhg.2008.61 Gauthier J, 2010, P NATL ACAD SCI USA, V107, P7863, DOI 10.1073/pnas.0906232107 Gemelli T, 2006, BIOL PSYCHIAT, V59, P468, DOI 10.1016/j.biopsych.2005.07.025 Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006 Gillberg C., 2000, BIOL AUTISTIC SYNDRO Gillott A, 2001, AUTISM, V5, P277, DOI 10.1177/1362361301005003005 Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953 Goorden SMI, 2007, ANN NEUROL, V62, P648, DOI 10.1002/ana.21317 Gould TD, 2009, NEUROMETHODS, V42, P1, DOI 10.1007/978-1-60761-303-9_1 Green V. A., 2007, AUTISM RES ADV, P63 Guy J, 2001, NAT GENET, V27, P322, DOI 10.1038/85899 Guy J, 2007, SCIENCE, V315, P1143, DOI 10.1126/science.1138389 Hascoet M, 2001, PROG NEURO-PSYCHOPH, V25, P141, DOI 10.1016/S0278-5846(00)00151-2 Heck DH, 2008, HUM MOL GENET, V17, P2181, DOI 10.1093/hmg/ddn117 Hines RM, 2008, J NEUROSCI, V28, P6055, DOI 10.1523/JNEUROSCI.0032-08.2008 Hung AY, 2008, J NEUROSCI, V28, P1697, DOI 10.1523/JNEUROSCI.3032-07.2008 Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105 Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136 JIANG YH, 2010, PLOS ONE, V5, P1 Jiang YH, 1998, NEURON, V21, P799, DOI 10.1016/S0896-6273(00)80596-6 Kalcounis-Rueppell MC, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009705 KALCOUNISRUEPPE.MC, 2006, ZOOLOGY, V3, P3 Kelleher RJ, 2008, CELL, V135, P401, DOI 10.1016/j.cell.2008.10.017 Kerr B, 2008, HUM MOL GENET, V17, P1707, DOI 10.1093/hmg/ddn061 Kirov G, 2008, HUM MOL GENET, V17, P458, DOI 10.1093/hmg/ddm323 KULKARNI SK, 1991, METHOD FIND EXP CLIN, V13, P573 Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023 Latham N, 2004, APPL ANIM BEHAV SCI, V86, P261, DOI 10.1016/j.applanim.2004.02.006 Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137 Lawson-Yuen A, 2008, EUR J HUM GENET, V16, P614, DOI 10.1038/sj.ejhg.5202006 Lawson-Yuen A, 2007, BRAIN RES, V1180, P1, DOI 10.1016/j.brainres.2007.08.039 Li H, 2003, EUR J NEUROSCI, V17, P929, DOI 10.1046/j.1460-9568.2003.02514.x Li WD, 2005, CURR BIOL, V15, P1961, DOI 10.1016/j.cub.2005.09.043 LISTER RG, 1987, PSYCHOPHARMACOLOGY, V92, P180 Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 McGill BE, 2006, P NATL ACAD SCI USA, V103, P18267, DOI 10.1073/pnas.0608702103 Meikle L, 2007, J NEUROSCI, V27, P5546, DOI 10.1523/JNEUROSCI.5540-06.2007 Moessner R, 2007, AM J HUM GENET, V81, P1289, DOI 10.1086/522S90 Moretti P, 2005, HUM MOL GENET, V14, P205, DOI 10.1093/hmg/ddi016 Moretti P, 2006, J NEUROSCI, V26, P319, DOI 10.1523/JNEUROSCI.2623-05.2006 Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657 Musolf K, 2010, ANIM BEHAV, V79, P757, DOI 10.1016/j.anbehav.2009.12.034 Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024 Ogawa S, 2007, BRAIN RES, V1168, P112, DOI 10.1016/j.brainres.2007.06.074 Page DT, 2009, P NATL ACAD SCI USA, V106, P1989, DOI 10.1073/pnas.0804428106 Palanza P, 2005, ANIM BEHAV, V69, P1259, DOI 10.1016/j.anbehav.2004.09.014 Paylor R, 2008, BEHAV NEUROSCI, V122, P1371, DOI 10.1037/a0013047 Pelka GJ, 2006, BRAIN, V129, P887, DOI 10.1093/brain/awl022 Picker JD, 2006, NEUROREPORT, V17, P541, DOI 10.1097/01.wnr.0000208995.38695.2f Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 Portfors CV, 2007, J AM ASSOC LAB ANIM, V46, P28 R Development Core Team, 2009, R LANG ENV STAT COMP Radyushkin K, 2009, GENES BRAIN BEHAV, V8, P416, DOI 10.1111/j.1601-183X.2009.00487.x Restivo L, 2005, P NATL ACAD SCI USA, V102, P11557, DOI 10.1073/pnas.0504984102 Ricceri L, 2008, BEHAV PHARMACOL, V19, P501, DOI 10.1097/FBP.0b013e32830c3645 Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x Roohi J, 2009, J MED GENET, V46, P176, DOI 10.1136/jmg.2008.057505 Rosser Tena L, 2003, Curr Neurol Neurosci Rep, V3, P129, DOI 10.1007/s11910-003-0064-3 ROULLET F, 2010, IMFAR C PHIL Samaco RC, 2008, HUM MOL GENET, V17, P1718, DOI 10.1093/hmg/ddn062 Santos M, 2007, GENES BRAIN BEHAV, V6, P277, DOI 10.1111/j.1601-183X.2006.00258.x Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067 Shahbazian MD, 2002, NEURON, V35, P243, DOI 10.1016/S0896-6273(02)00768-7 Silva AJ, 2009, J NEURODEV DISORD, V1, P150, DOI 10.1007/s11689-009-9018-7 Silva AJ, 1997, NAT GENET, V15, P281, DOI 10.1038/ng0397-281 Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851 Spencer CA, 2008, BEHAV NEUROSCI, V122, P710, DOI 10.1037/0735-7044.122.3.710 Spencer CM, 2006, HUM MOL GENET, V15, P1984, DOI 10.1093/hmg/ddl121 Stearns NA, 2007, NEUROSCIENCE, V146, P907, DOI 10.1016/j.neuroscience.2007.02.009 Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221 Takeda Y, 2003, J NEUROBIOL, V56, P252, DOI 10.1002/neu.10222 Toro R, 2010, TRENDS GENET, V26, P363, DOI 10.1016/j.tig.2010.05.007 Uhlmann EJ, 2002, ANN NEUROL, V52, P285, DOI 10.1002/ana.10283 van Woerden GM, 2007, NAT NEUROSCI, V10, P280, DOI 10.1038/nn1845 Wiznitzer M, 2004, J CHILD NEUROL, V19, P675 Ylisaukko-oja T, 2005, EUR J HUM GENET, V13, P1285, DOI 10.1038/sj.ejhg.5201474 Young DM, 2010, P NATL ACAD SCI USA, V107, P11074, DOI 10.1073/pnas.1005620107 Zang JB, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000758 Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009 Zweier C, 2009, AM J HUM GENET, V85, P655, DOI 10.1016/j.ajhg.2009.10.004 NR 114 TC 51 Z9 51 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2011 VL 4 IS 1 SI SI BP 5 EP 16 DI 10.1002/aur.175 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 729JP UT WOS:000287945900002 PM 21328568 ER PT J AU Yang, M Perry, K Weber, MD Katz, AM Crawley, JN AF Yang, Mu Perry, Kayla Weber, Michael D. Katz, Adam M. Crawley, Jacqueline N. TI Social Peers Rescue Autism-Relevant Sociability Deficits in Adolescent Mice SO AUTISM RESEARCH LA English DT Article DE autism; BTBR inbred strain; mouse model; peer enrichment; social enrichment; behavioral intervention ID FRAGILE-X-SYNDROME; INTENSIVE BEHAVIORAL TREATMENT; INTEGRATED PLAY GROUPS; BTBR-T+TF/J MICE; SPECTRUM DISORDERS; REPETITIVE BEHAVIOR; INBRED STRAINS; EARLY-CHILDHOOD; TASKS RELEVANT; MOUSE MODELS AB Behavioral therapies are currently the most effective interventions for treating the diagnostic symptoms of autism. We employed a mouse model of autism to evaluate components of behavioral interventions that improve sociability in mice. BTBR T+tf/J (BTBR) is an inbred mouse strain that exhibits prominent behavioral phenotypes with face validity to all three diagnostic symptom categories of autism, including robust and well-replicated deficits in social approach and reciprocal social interactions. To investigate the role of peer interactions in the development of sociability, BTBR juvenile mice were reared in the same home cage with juvenile mice of a highly social inbred strain, C57BL/6J (B6). Subject mice were tested as young adults for sociability and repetitive behaviors. B6 controls reared with B6 showed their strain-typical high sociability. BTBR controls reared with BTBR showed their strain-typical lack of sociability. In contrast, BTBR reared with B6 as juveniles showed significant sociability as young adults. A 20-day intervention was as effective as a 40-day intervention for improving social approach behavior. High levels of repetitive self-grooming in BTBR were not rescued by peer-rearing with B6, indicating specificity of the intervention to the social domain. These results from a robust mouse model of autism support the interpretation that social enrichment with juvenile peers is a beneficial intervention for improving adult outcome in the social domain. This novel paradigm may prove useful for discovering factors that are essential for effective behavioral treatments, and biological mechanisms underlying effective behavioral interventions. C1 [Yang, Mu] NIMH, Lab Behav Neurosci, Intramural Res Program, NIH, Bethesda, MD 20892 USA. RP Yang, M (reprint author), NIMH, Lab Behav Neurosci, Intramural Res Program, NIH, Bldg 35,Room 1C-909,Mail Code 3730, Bethesda, MD 20892 USA. EM yangmu@mail.nih.gov FU National Institute of Mental Health FX Grant sponsor: National Institute of Mental Health Intramural Research Program. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Bartz JA, 2008, PROG BRAIN RES, V170, P451, DOI 10.1016/S0079-6123(08)00435-4 Bear MF, 2004, TRENDS NEUROSCI, V27, P370, DOI 10.1016/j.tins.2004.04.009 Betz A, 2008, J APPL BEHAV ANAL, V41, P237, DOI 10.1901/jaba.2008.41-237 Billstedt E, 2005, J AUTISM DEV DISORD, V35, P351, DOI 10.1007/s10803-005-3302-5 Billstedt E, 2007, J CHILD PSYCHOL PSYC, V48, P1102, DOI 10.1111/j.1469-7610.2007.01774.x Blundell J, 2010, J NEUROSCI, V30, P2115, DOI 10.1523/JNEUROSCI.4517-09.2010 Bolivar VJ, 2007, BEHAV BRAIN RES, V176, P21, DOI 10.1016/j.bbr.2006.09.007 Branchi I, 2009, NEUROSCI BIOBEHAV R, V33, P551, DOI 10.1016/j.neubiorev.2008.03.011 Brodkin ES, 2007, BEHAV BRAIN RES, V176, P53, DOI 10.1016/j.bbr.2006.06.025 CAUSTONTHEOHARI.J, 2009, J INTELLECT DEV DIS, V47, P84 Cederlund M, 2008, J AUTISM DEV DISORD, V38, P72, DOI 10.1007/s10803-007-0364-6 Chadman KK, 2009, AM J MED GENET B, V150B, P1, DOI 10.1002/ajmg.b.30777 Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22 Crawley JN, 2007, NEUROPEPTIDES, V41, P145, DOI 10.1016/j.npep.2007.02.002 Crawley Jacqueline N, 2007, Science, V318, P56, DOI 10.1126/science.1149801 Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039 Dawson G, 2009, PEDIATRICS, V125, pe17, DOI DOI 10.1542/PEDS.2009-0958 Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370 Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001 Kohler F W, 1995, Behav Modif, V19, P10, DOI 10.1177/01454455950191002 Ehninger D, 2008, NAT MED, V14, P843, DOI 10.1038/nm1788 Eikeseth S, 2002, BEHAV MODIF, V26, P49, DOI 10.1177/0145445502026001004 Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225 GOLDSTEIN H, 1992, J APPL BEHAV ANAL, V25, P289, DOI 10.1901/jaba.1992.25-289 Goldstein H, 1997, J SPEECH LANG HEAR R, V40, P33 Hagerman RJ, 2009, PEDIATRICS, V123, P378, DOI 10.1542/peds.2008-0317 Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8 HARLOW HF, 1971, P NATL ACAD SCI USA, V68, P1534, DOI 10.1073/pnas.68.7.1534 Harper CB, 2008, J AUTISM DEV DISORD, V38, P815, DOI 10.1007/s10803-007-0449-2 Hwang B, 2000, J AUTISM DEV DISORD, V30, P331, DOI 10.1023/A:1005579317085 Kaminsky L, 2002, J CHILD PSYCHOL PSYC, V43, P225, DOI 10.1111/1469-7610.00015 KAMPS DM, 1994, J APPL BEHAV ANAL, V27, P49, DOI 10.1901/jaba.1994.27-49 Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4 Koegel LK, 2001, BEHAV MODIF, V25, P745, DOI 10.1177/0145445501255005 Landa RJ, 2008, NAT CLIN PRACT NEURO, V4, P138, DOI 10.1038/ncpneuro0731 Levy SE, 2009, LANCET, V374, P1627, DOI 10.1016/S0140-6736(09)61376-3 Macks RJ, 2007, J AUTISM DEV DISORD, V37, P1060, DOI 10.1007/s10803-006-0249-0 McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x MCGEE GG, 1992, J APPL BEHAV ANAL, V25, P117, DOI 10.1901/jaba.1992.25-117 Moy SS, 2008, BEHAV BRAIN RES, V191, P118, DOI 10.1016/j.bbr.2008.03.015 Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030 Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x National Research Council, 2001, ED YOUNG CHILDR AUT Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007 Nordin V, 1998, ACTA PSYCHIAT SCAND, V97, P99, DOI 10.1111/j.1600-0447.1998.tb09970.x Ospina MB, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003755 Panksepp JB, 2007, GENES BRAIN BEHAV, V6, P661, DOI 10.1111/j.1601-183X.2006.00295.x Pilowsky T, 2004, J CHILD PSYCHOL PSYC, V45, P855, DOI 10.1111/j.1469-7610.2004.00277.x Prendeville Jo-Anne, 2006, Seminars in Speech and Language, V27, P32, DOI 10.1055/s-2006-932437 Rogers SJ, 2008, J CLIN CHILD ADOLESC, V37, P8, DOI 10.1080/15374410701817808 Rogers SJ, 2000, J AUTISM DEV DISORD, V30, P399, DOI 10.1023/A:1005543321840 Sallows GO, 2005, AM J MENT RETARD, V110, P417, DOI 10.1352/0895-8017(2005)110[417:IBTFCW]2.0.CO;2 Scattoni ML, 2010, GENES BRAIN BEHAV Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851 Silverman JL, 2010, NEUROPSYCHOPHARMACOL, V35, P976, DOI 10.1038/npp.2009.201 Strain Phillip S., 1998, Seminars in Speech and Language, V19, P391, DOI 10.1055/s-2008-1064056 STRAIN PS, 1998, SEMINARS SPEECH LANG, V19, P404 STRAIN PS, 1998, SEMINARS SPEECH LANG, V19, P424 Tanimura Y, 2008, BEHAV BRAIN RES, V189, P250, DOI 10.1016/j.bbr.2008.01.001 Trembath D, 2009, J INTELLECT DEV DIS, V34, P173, DOI 10.1080/13668250902845210 Veenstra-VanderWeele J, 2004, ANNU REV GENOM HUM G, V5, P379, DOI 10.1146/annurev.genom5.061903.180050 Verte S, 2003, CHILD CARE HLTH DEV, V29, P193, DOI 10.1046/j.1365-2214.2003.00331.x Vismara LA, 2010, ANNU REV CLIN PSYCHO, V6, P447, DOI 10.1146/annurev.clinpsy.121208.131151 Volkmar F, 2005, ANNU REV PSYCHOL, V56, P315, DOI 10.1146/annurev.psych.56.091103.070159 Volkmar F. R., 2009, J AUTISM DEV DISORD, V40, P149 Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104 West L, 2009, J PEDIATR HEALTH CAR, V23, P75, DOI 10.1016/j.pedhc.2008.12.001 Winslow JT, 2003, CURR PROTOC NEUROSCI Wirojanan J, 2009, J CLIN SLEEP MED, V5, P145 WOHR M, 2010, GENES BRAIN BEHAV WOLFBERG PJ, 1993, J AUTISM DEV DISORD, V23, P467, DOI 10.1007/BF01046051 YANG M, 2010, AUTISM SPECTRUM DISO Yang M, 2009, EUR J NEUROSCI, V29, P1663, DOI 10.1111/j.1460-9568.2009.06714.x Yang M, 2007, INT J DEV NEUROSCI, V25, P515, DOI 10.1016/j.ijdevneu.2007.09.008 Yang M, 2007, FRONT BEHAV NEUROSCI, V1, DOI [10.3389/neuro.08.001.2007, 10.3389/neuro.08/001.2007] Yang TR, 2003, AUTISM, V7, P437, DOI 10.1177/1362361303007004009 Zercher C, 2001, AUTISM, V5, P374, DOI 10.1177/1362361301005004004 Zhou J, 2009, J NEUROSCI, V29, P1773, DOI 10.1523/JNEUROSCI.5685-08.2009 NR 80 TC 32 Z9 32 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2011 VL 4 IS 1 SI SI BP 17 EP 27 DI 10.1002/aur.163 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 729JP UT WOS:000287945900003 PM 20928844 ER PT J AU Sakurai, T Dorr, NP Takahashi, N McInnes, LA Elder, GA Buxbaum, JD AF Sakurai, Takeshi Dorr, Nathan P. Takahashi, Nagahide McInnes, L. Alison Elder, Gregory A. Buxbaum, Joseph D. TI Haploinsufficiency of Gtf2i, a Gene Deleted in Williams Syndrome, Leads to Increases in Social Interactions SO AUTISM RESEARCH LA English DT Article DE social behavior; intellectual disability; autism; mouse model ID BEUREN-SYNDROME; MICE; AUTISM AB Identifying genes involved in social behavior is important for autism research. Williams-Beuren syndrome (WBS) is a developmental syndrome with unique neurocognitive features, including low IQ deficits in visuospatial and visual-motor abilities, hypersensitivity to sounds, hypersociability, and increased general anxiety. The syndrome is caused by a recurrent hemizygous deletion of the 7q11.23 region, containing about 28 genes. One of genes in the region, GTF2I, has been implicated in the hypersociability and visuospatial deficits of WBS based on genotype-phenotype correlation studies of patients with atypical deletions. In order to clarify the involvement of GTF2I in neurocognitive function, especially social behavior, we have developed and characterized Gtf2i-deficient mice. We found that homozygous deletion of Gtf2i causes lethality during embryonic development with neural tube closure defects and exencephaly, consistent with other reports. Gtf2i heterozygous animals show no gross changes in brain structure or development. Furthermore, heterozygous animals show no alterations in learning and memory, including spatial memory as assessed by the Morris water maze, but show alterations in the recognition of novel objects. Interestingly, they show increased social interaction with unfamiliar mice and do not show typical social habituation processes, reminiscent of the hypersociability observed in WBS patients. The mice do not appear to show increased anxiety, supporting a specific effect of Gtf2i on defined domains of the WBS phenotype. These data indicate that Gtf2i is involved in several aspects of embryonic development and the development of social neurocircuitry and that GTF2I haploinsufficiency could be a contributor to the hypersociability in WBS patients. C1 [Sakurai, Takeshi; Dorr, Nathan P.; Takahashi, Nagahide; McInnes, L. Alison; Elder, Gregory A.; Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA. [Sakurai, Takeshi; McInnes, L. Alison; Buxbaum, Joseph D.] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA. [Sakurai, Takeshi] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA. [Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA. [Elder, Gregory A.] Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA. [Buxbaum, Joseph D.] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USA. [Elder, Gregory A.] Vet Affairs Med Ctr, James J Peters Dept, Neurol Serv, Bronx, NY USA. RP Buxbaum, JD (reprint author), Mt Sinai Sch Med, Dept Psychiat, 1 Gustave L Levy Pl,Box 1668, New York, NY 10029 USA. EM joseph.buxbaum@mssm.edu FU Seaver Foundation; Office of Mount Sinai School of Medicine FX Grant sponsor: The Seaver Foundation.This research was supported by the Seaver Foundation. T.S. and L.A.M. are current and prior Seaver Fellows, respectively. The Mount Sinai Rat and Mouse Phenotyping Shared Research Facility was supported in part by the Dean's Office of Mount Sinai School of Medicine. The authors thank Dr. Ananda Roy for the generous gift of an antibody. CR Antonell A, 2010, J MED GENET, V47, P312, DOI 10.1136/jmg.2009.071712 Chimge NO, 2008, P NATL ACAD SCI USA, V105, P9006, DOI 10.1073/pnas.0803051105 Copp AJ, 2010, J PATHOL, V220, P217, DOI 10.1002/path.2643 Dai L, 2009, AM J MED GENET A, V149A, P302, DOI 10.1002/ajmg.a.32652 Edelmann L, 2007, J MED GENET, V44, P136, DOI 10.1136/jmg.2006.044537 Elder GA, 2008, BEHAV BRAIN RES, V191, P256, DOI 10.1016/j.bbr.2008.03.036 Enkhmandakh B, 2009, P NATL ACAD SCI USA, V106, P181, DOI 10.1073/pnas.0811531106 EWART AK, 1993, NAT GENET, V5, P11, DOI 10.1038/ng0993-11 Ferrero GB, 2010, EUR J HUM GENET, V18, P33, DOI 10.1038/ejhg.2009.108 Gao MC, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010292 Lazebnik MB, 2009, J BIOL CHEM, V284, P36234, DOI 10.1074/jbc.C109.063115 Li HH, 2009, EMBO MOL MED, V1, P50, DOI 10.1002/emmm.200900003 MAKEYEV A, 2010, CLEFT PALATE CRANIOF Merla G, 2010, HUM GENET, V128, P3, DOI 10.1007/s00439-010-0827-2 Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030 Osborne LR, 2010, AM J MED GENET C, V154C, P209, DOI 10.1002/ajmg.c.30257 Pober BR, 2010, NEW ENGL J MED, V362, P239, DOI 10.1056/NEJMra0903074 Rogers DC, 1997, MAMM GENOME, V8, P711, DOI 10.1007/s003359900551 Sakurai T, 2010, BIOL PSYCHIAT, V67, P887, DOI 10.1016/j.biopsych.2009.08.042 Tassabehji M, 2005, SCIENCE, V310, P1184, DOI 10.1126/science.1116142 van Hagen JM, 2007, NEUROBIOL DIS, V26, P112, DOI 10.1016/j.nbd.2006.12.009 Young EJ, 2008, GENES BRAIN BEHAV, V7, P224, DOI 10.1111/j.1601-183X.2007.00343.x NR 22 TC 17 Z9 17 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2011 VL 4 IS 1 SI SI BP 28 EP 39 DI 10.1002/aur.169 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 729JP UT WOS:000287945900004 PM 21328569 ER PT J AU Spencer, CM Alekseyenko, O Hamilton, SM Thomas, AM Serysheva, E Yuva-Paylor, LA Paylor, R AF Spencer, Corinne M. Alekseyenko, Olga Hamilton, Shannon M. Thomas, Alexia M. Serysheva, Ekaterina Yuva-Paylor, Lisa A. Paylor, Richard TI Modifying Behavioral Phenotypes in Fmr1KO Mice: Genetic Background Differences Reveal Autistic-Like Responses SO AUTISM RESEARCH LA English DT Article DE fragile X syndrome; autism; genetic; behavior; animal model; mouse model ID FRAGILE-X-SYNDROME; INBRED MOUSE STRAINS; SENSORIMOTOR GATING ABNORMALITIES; KNOCKOUT MICE; ULTRASONIC VOCALIZATIONS; SPECTRUM DISORDERS; MENTAL-RETARDATION; SOCIAL-BEHAVIOR; TASKS RELEVANT; MUTANT MOUSE AB Fragile X syndrome (FXS) is the most common inherited form of intellectual disability in humans. In addition to cognitive impairment, patients may exhibit hyperactivity, attention deficits, social difficulties and anxiety, and autistic-like behaviors. The degree to which patients display these behaviors varies considerably and is influenced by family history, suggesting that genetic modifiers play a role in the expression of behaviors in FXS. Several studies have examined behavior in a mouse model of FXS in which the Fmr1 gene has been ablated. Most of those studies were done in Fmr1 knockout mice on a pure C57BL/6 or FVB strain background. To gain a better understanding of the effects of genetic background on behaviors resulting from the loss of Fmr1 gene expression, we generated F1 hybrid lines from female Fmr1 heterozygous mice on a pure C57BL/6J background bred with male Fmr1 wild-type (WT) mice of various background strains (A/J, DBA/2J, FVB/NJ, 129S1/SvImJ and CD-1). Male Fmr1 knockout and WT littermates from each line were examined in an extensive behavioral test battery. Results clearly indicate that multiple behavioral responses are dependent on genetic background, including autistic-like traits that are present on limited genetic backgrounds. This approach has allowed us to identify improved models for different behavioral symptoms present in FXS including autistic-like traits. C1 [Spencer, Corinne M.; Alekseyenko, Olga; Serysheva, Ekaterina; Yuva-Paylor, Lisa A.; Paylor, Richard] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA. [Hamilton, Shannon M.; Thomas, Alexia M.; Paylor, Richard] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA. RP Paylor, R (reprint author), Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA. EM rpaylor@bcm.edu FU NIH/NICHD Baylor Intellectual and Developmental Disabilities Research Center; Baylor Fragile X Research Center FX Grant sponsor: Administrative and Neurobehavioral Cores of the NIH/NICHD Baylor Intellectual and Developmental Disabilities Research Center and the Baylor Fragile X Research Center. CR ABITBOL M, 1993, NAT GENET, V4, P147, DOI 10.1038/ng0693-147 [Anonymous], 1997, NEURON, V19, P755 ASHLEY CT, 1993, SCIENCE, V262, P563, DOI 10.1126/science.7692601 Bothe GWM, 2004, GENES BRAIN BEHAV, V3, P149, DOI 10.1111/j.1601-183x.2004.00064.x Bouwknecht JA, 2002, BEHAV BRAIN RES, V136, P489, DOI 10.1016/S0166-4328(02)00200-0 Branchi I, 2001, BEHAV BRAIN RES, V125, P49, DOI 10.1016/S0166-4328(01)00277-7 BROEKKAMP CL, 1986, EUR J PHARMACOL, V126, P223, DOI 10.1016/0014-2999(86)90051-8 Carcani-Rathwell I, 2006, J CHILD PSYCHOL PSYC, V47, P573, DOI 10.1111/j.1469-7610.2005.01565.x BAKKER CE, 1994, CELL, V78, P23 CRABBE JC, 1982, ALCOHOL CLIN EXP RES, V6, P446, DOI 10.1111/j.1530-0277.1982.tb05007.x CRAWLEY J, 1980, PHARMACOL BIOCHEM BE, V13, P167, DOI 10.1016/0091-3057(80)90067-2 Crawley J.M., 1989, CURR OPIN PSYCHIATR, V2, P773, DOI 10.1097/00001504-198912000-00012 Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x Crawley JN, 1997, PSYCHOPHARMACOLOGY, V132, P107, DOI 10.1007/s002130050327 Crawley JN, 2004, MENT RETARD DEV D R, V10, P248, DOI 10.1002/mrdd.20039 Bernardet M, 2006, THESCIENTIFICWORLDJO, V6, P1164, DOI 10.1100/tsw.2006.220 Crusio WE, 2004, BIOL PSYCHIAT, V56, P381, DOI 10.1016/j.biopsych.2003.12.026 D'Amato FR, 2005, BEHAV GENET, V35, P103, DOI 10.1007/s10519-004-0860-9 DHooge R, 1997, NEUROSCIENCE, V76, P367, DOI 10.1016/S0306-4522(96)00224-2 Ehret G, 2005, BEHAV GENET, V35, P19, DOI 10.1007/s10519-004-0853-8 Esposito G, 2010, J INTELL DISABIL RES, V54, P216, DOI 10.1111/j.1365-2788.2010.01252.x Fisch GS, 1999, AM J MED GENET, V84, P277, DOI 10.1002/(SICI)1096-8628(19990528)84:3<277::AID-AJMG22>3.0.CO;2-W Francis DD, 2003, NAT NEUROSCI, V6, P445, DOI 10.1038/nn1038 Frankland PW, 2004, MOL PSYCHIATR, V9, P417, DOI 10.1038/sj.mp.4001432 HAGERMAN RJ, 2002, FRAGILE X SYNDROME E, V2, P3 Hessl D, 2001, PEDIATRICS, V108, part. no., DOI 10.1542/peds.108.5.e88 HINDS HL, 1993, NAT GENET, V3, P36, DOI 10.1038/ng0193-36 Holmes A, 2002, NEUROPSYCHOPHARMACOL, V27, P914, DOI 10.1016/S0893-133X(02)00374-3 Jamain S, 2008, P NATL ACAD SCI USA, V105, P1710, DOI 10.1073/pnas.0711555105 Kooy RF, 1996, AM J MED GENET, V64, P241, DOI 10.1002/(SICI)1096-8628(19960809)64:2<241::AID-AJMG1>3.0.CO;2-X Kudryavtseva N N, 2003, Neurosci Behav Physiol, V33, P461, DOI 10.1023/A:1023411217051 KUDRYAVTSEVA NN, 1994, BEHAV PROCESS, V32, P297, DOI 10.1016/0376-6357(94)90049-3 Liu ZH, 2009, NEUROSCI LETT, V454, P62, DOI 10.1016/j.neulet.2009.02.066 Logue SE, 1997, BEHAV NEUROSCI, V111, P104, DOI 10.1037/0735-7044.111.1.104 MARKS MJ, 1989, PHARMACOL BIOCHEM BE, V33, P667, DOI 10.1016/0091-3057(89)90406-1 McNaughton CH, 2008, BEHAV NEUROSCI, V122, P293, DOI [10.1037/0735-7044.122.2.293, 10.1037/0735-7044A22.2.293] Mines MA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009706 Mineur YS, 2006, BEHAV BRAIN RES, V168, P172, DOI 10.1016/j.bbr.2005.11.004 Moon J, 2006, BEHAV NEUROSCI, V120, P1367, DOI 10.1037/0735-7044.120.6.1367 Moon J, 2008, DEV PSYCHOBIOL, V50, P473, DOI 10.1002/dev.20308 Moss J, 2009, J INTELL DISABIL RES, V53, P852, DOI 10.1111/j.1365-2788.2009.01197.x Moy SS, 2008, BEHAV BRAIN RES, V191, P118, DOI 10.1016/j.bbr.2008.03.015 Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030 Moy SS, 2008, MOL PSYCHIATR, V13, P4, DOI 10.1038/sj.mp.4002082 Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029 Moy SS, 2006, AM J MED GENET C, V142C, P40, DOI 10.1002/ajmg.c.30081 Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024 Nielsen DM, 2002, BRAIN RES, V927, P8, DOI 10.1016/S0006-8993(01)03309-1 NJUNGE K, 1991, PHARMACOL BIOCHEM BE, V38, P63, DOI 10.1016/0091-3057(91)90590-X Owen EH, 1997, NEUROSCIENCE, V80, P1087, DOI 10.1016/S0306-4522(97)00165-6 Paradee W, 1999, NEUROSCIENCE, V94, P185, DOI 10.1016/S0306-4522(99)00285-7 Paylor R, 2006, PHYSIOL BEHAV, V87, P95, DOI 10.1016/j.physbeh.2005.09.002 Paylor R, 2008, BEHAV NEUROSCI, V122, P1371, DOI 10.1037/a0013047 Peier AM, 2000, HUM MOL GENET, V9, P1145, DOI 10.1093/hmg/9.8.1145 Picker JD, 2006, NEUROREPORT, V17, P541, DOI 10.1097/01.wnr.0000208995.38695.2f Price TJ, 2007, J NEUROSCI, V27, P13958, DOI 10.1523/JNEUROSCI.4383-07.2007 Radyushkin K, 2009, GENES BRAIN BEHAV, V8, P416, DOI 10.1111/j.1601-183X.2009.00487.x Scattoni ML, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003067 Scattoni ML, 2009, NEUROSCI BIOBEHAV R, V33, P508, DOI 10.1016/j.neubiorev.2008.08.003 Schalkwyk LC, 2007, GENES BRAIN BEHAV, V6, P299, DOI 10.1111/j.1601-183X.2007.00304.x SHERMAN S, 2002, FRAGILE X SYNDROME E, V3, P136 Sobesky WE, 1995, DEV BRAIN DYSFUNCT, V8, P280 Spencer CA, 2008, BEHAV NEUROSCI, V122, P710, DOI 10.1037/0735-7044.122.3.710 Spencer CM, 2005, GENES BRAIN BEHAV, V4, P420, DOI 10.1111/j.1601-183X.00123.x Spencer CM, 2006, HUM MOL GENET, V15, P1984, DOI 10.1093/hmg/ddl121 Symons FJ, 2003, AM J MED GENET A, V118A, P115, DOI 10.1002/ajmg.a.10078 Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y Weller A, 2003, DEV PSYCHOBIOL, V42, P194, DOI 10.1002/dev.10079 Zang JB, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000758 Zupan B, 2008, NEUROPSYCHOPHARMACOL, V33, P2667, DOI 10.1038/sj.npp.1301651 NR 71 TC 56 Z9 57 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2011 VL 4 IS 1 SI SI BP 40 EP 56 DI 10.1002/aur.168 PG 17 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 729JP UT WOS:000287945900005 PM 21268289 ER PT J AU Carter, MD Shah, CR Muller, CL Crawley, JN Carneiro, AMD Veenstra-VanderWeele, J AF Carter, Michelle D. Shah, Charisma R. Muller, Christopher L. Crawley, Jacqueline N. Carneiro, Ana M. D. Veenstra-VanderWeele, Jeremy TI Absence of Preference for Social Novelty and Increased Grooming in Integrin beta 3 Knockout Mice: Initial Studies and Future Directions SO AUTISM RESEARCH LA English DT Article DE autism; genetic; integrin; cell adhesion; serotonin; social memory; grooming; obsessive-compulsive disorder ID WHOLE-BLOOD SEROTONIN; AUTISM SPECTRUM DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS; RECEPTOR GENE OXTR; COPY NUMBER VARIATION; MOUSE MODEL; 1ST-DEGREE RELATIVES; MENTAL-RETARDATION; ULTRASONIC VOCALIZATIONS; BEHAVIORAL PHENOTYPES AB Elevated whole blood serotonin 5-HT, or hyperserotonemia, is a common biomarker in autism spectrum disorder (ASD). The integrin beta 3 receptor subunit gene (ITGB3) is a quantitative trait locus for whole blood 5-HT levels. Recent work shows that integrin beta 3 interacts with the serotonin transporter (SERT) in both platelets and in the midbrain. Furthermore, multiple studies have now reported gene gene interaction between the integrin beta 3 and SERT genes in association with ASD. Given the lack of previous data on the impact of integrin beta 3 on brain or behavioral phenotypes, we sought to compare mice with decreased or absent expression of the integrin beta 3 receptor subunit (Itgb3+/- and -/-) with wildtype littermate controls in behavioral tasks relevant to ASD. These mice did not show deficits in activity level in the open field or anxiety-like behavior on the elevated plus maze, two potential confounds in the evaluation of mouse social behavior. In the three-chamber social test, mice lacking integrin beta 3 were shown to have normal sociability but did not show a preference for social novelty. Importantly, the absence of integrin beta 3 did not impair olfaction or the ability to recall familiar social odors. Additionally, mice lacking integrin beta 3 showed increased grooming behavior in novel environments. These preliminary studies reveal altered social and repetitive behavior in these mice, which suggests that the integrin beta 3 subunit may be involved in brain systems relevant to ASD. Further work is needed to fully characterize these behavioral changes and the underlying brain mechanisms. C1 [Carter, Michelle D.; Shah, Charisma R.; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Psychiat, Nashville, TN USA. [Muller, Christopher L.; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Ctr Mol Neurosci, Nashville, TN USA. [Crawley, Jacqueline N.] NIMH, Lab Behav Neurosci, Bethesda, MD 20892 USA. [Carneiro, Ana M. D.; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Pharmacol, Nashville, TN USA. [Carneiro, Ana M. D.; Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Kennedy Ctr Res Human Dev, Nashville, TN USA. [Veenstra-VanderWeele, Jeremy] Vanderbilt Univ, Dept Pediat, Nashville, TN USA. RP Veenstra-VanderWeele, J (reprint author), 465 21st Ave S,7158 MRB 3, Nashville, TN 37232 USA. EM j.vvw@vanderbilt.edu FU Seaside Therapeutics; Roche Pharmaceuticals; Novartis; NIH [K08-MH081066, T32-MH065215, HD15052]; NIH (Vanderbilt Kennedy Center) [T32-MH065215, HD15052, MH081066] FX Dr. Veenstra-VanderWeele receives research support from Seaside Therapeutics, Roche Pharmaceuticals, and Novartis, for clinical trials unrelated to the current research.Grant sponsor: NIH; Grant numbers: K08-MH081066; T32-MH065215; HD15052.We are especially grateful to the families who participated in the original genetic studies. We also thank Randy Blakely for helpful advice and generous mentorship. This work was supported, in part, by NIH grants MH081066 (JV), T32-MH065215 (JV), and HD15052 (Vanderbilt Kennedy Center). CR Abney M, 2001, AM J HUM GENET, V68, P1302, DOI 10.1086/320112 Abramoff M.D., 2004, BIOPHOTONICS INT, V11, P36, DOI DOI 10.1117/1.3589100 ABRAMSON RK, 1989, J AUTISM DEV DISORD, V19, P397, DOI 10.1007/BF02212938 Adolphs R, 2009, ANNU REV PSYCHOL, V60, P693, DOI 10.1146/annurev.psych.60.110707.163514 American Psychiatric Association, 2000, DIAGN STAT MAN MENT ANDERSON GM, 1987, LIFE SCI, V40, P1063, DOI 10.1016/0024-3205(87)90568-6 BAILEY A, 1995, PSYCHOL MED, V25, P63 Berkel S, 2010, NAT GENET, V42, P489, DOI 10.1038/ng.589 Blundell J, 2010, J NEUROSCI, V30, P2115, DOI 10.1523/JNEUROSCI.4517-09.2010 Bourgeron T, 2009, CURR OPIN NEUROBIOL, V19, P231, DOI 10.1016/j.conb.2009.06.003 Brune CW, 2006, AM J PSYCHIAT, V163, P2148, DOI 10.1176/appi.ajp.163.12.2148 Buxbaum Joseph D, 2009, Dialogues Clin Neurosci, V11, P35 Carneiro AMD, 2008, J CLIN INVEST, V118, P1544, DOI 10.1172/JCI33374 Chadman KK, 2008, AUTISM RES, V1, P147, DOI 10.1002/aur.22 Chakrabarti S, 2001, JAMA-J AM MED ASSOC, V285, P3093, DOI 10.1001/jama.285.24.3093 Chavis P, 2001, NATURE, V411, P317, DOI 10.1038/35077101 Chen SK, 2010, CELL, V141, P775, DOI 10.1016/j.cell.2010.03.055 Cingolani LA, 2008, NEURON GLIA BIOL, V4, P179, DOI 10.1017/S1740925X0999024X Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524 Cook Edwin H. Jr., 1996, Current Opinion in Pediatrics, V8, P348, DOI 10.1097/00008480-199608000-00008 Cook EH, 1997, AM J HUM GENET, V60, P928 Coutinho AM, 2007, HUM GENET, V121, P243, DOI 10.1007/s00439-006-0301-3 Crawley JN, 2007, NEUROPEPTIDES, V41, P145, DOI 10.1016/j.npep.2007.02.002 Cross S, 2008, NEUROPSYCHOPHARMACOL, V33, P353, DOI 10.1038/sj.npp.1301406 CUCCARO ML, 1993, J NEUROPSYCH CLIN N, V5, P94 Drew CJG, 2007, HUM MOL GENET, V16, P2288, DOI 10.1093/hmg/ddm181 Etherton MR, 2009, P NATL ACAD SCI USA, V106, P17998, DOI 10.1073/pnas.0910297106 Ferguson JN, 2000, NAT GENET, V25, P284, DOI 10.1038/77040 Ferguson JN, 2001, J NEUROSCI, V21, P8278 FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225 Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953 Gregory SG, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-62 Hart PC, 2010, METHODS MOL BIOL, V602, P299, DOI 10.1007/978-1-60761-058-8_18 Hodivala-Dilke KM, 1999, J CLIN INVEST, V103, P229, DOI 10.1172/JCI5487 Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001 Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136 Jin D, 2007, NATURE, V446, P41, DOI 10.1038/nature05526 Joosten AV, 2009, J AUTISM DEV DISORD, V39, P521, DOI 10.1007/s10803-008-0654-7 Kanner L, 1943, NERV CHILD, V2, P217 Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011 Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376 Kwon CH, 2006, NEURON, V50, P377, DOI 10.1016/j.neuron.2006.03.023 Laumonnier F, 2004, AM J HUM GENET, V74, P552, DOI 10.1086/382137 Leboyer M, 1999, BIOL PSYCHIAT, V45, P158, DOI 10.1016/S0006-3223(97)00532-5 Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087 LEVENTHAL BL, 1990, J AUTISM DEV DISORD, V20, P499, DOI 10.1007/BF02216055 Lijam N, 1997, CELL, V90, P895, DOI 10.1016/S0092-8674(00)80354-2 Liu XX, 2010, J HUM GENET, V55, P137, DOI 10.1038/jhg.2009.140 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Ma DQ, 2010, AM J MED GENET B, V153B, P477, DOI 10.1002/ajmg.b.31003 Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 McFarlane HG, 2008, GENES BRAIN BEHAV, V7, P152, DOI 10.1111/j.1601-183X.2007.00330.x McHugh KP, 2000, J CLIN INVEST, V105, P433, DOI 10.1172/JCI8905 McNaughton CH, 2008, BEHAV NEUROSCI, V122, P293, DOI [10.1037/0735-7044.122.2.293, 10.1037/0735-7044A22.2.293] Mei H, 2007, AM J HUM GENET, V81, P1251, DOI 10.1086/522307 Miyakawa T, 2001, J NEUROSCI, V21, P5239 Molina J, 2008, HUM MOL GENET, V17, P2486, DOI 10.1093/hmg/ddn148 Moretti P, 2005, HUM MOL GENET, V14, P205, DOI 10.1093/hmg/ddi016 Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657 Moy SS, 2007, BEHAV BRAIN RES, V176, P4, DOI 10.1016/j.bbr.2006.07.030 Moy SS, 2009, GENES BRAIN BEHAV, V8, P129, DOI 10.1111/j.1601-183X.2008.00452.x Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029 Moy SS, 2004, GENES BRAIN BEHAV, V3, P287, DOI 10.1111/j.1601-183X.2004.00076.x Mulder EJ, 2004, J AM ACAD CHILD PSY, V43, P491, DOI 10.1097/01.chi.0000111365.94169.b0 Munson J, 2008, AM J MENT RETARD, V113, P439, DOI 10.1352/2008.113:439-452 Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024 O'Roak BJ, 2008, AUTISM RES, V1, P4, DOI 10.1002/aur.3 O'Tuathaigh CMP, 2007, NEUROSCIENCE, V147, P18, DOI 10.1016/j.neuroscience.2007.03.051 Park J, 2010, PROG NEURO-PSYCHOPH, V34, P697, DOI 10.1016/j.pnpbp.2010.03.029 Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 Radyushkin K, 2009, GENES BRAIN BEHAV, V8, P416, DOI 10.1111/j.1601-183X.2009.00487.x Ramocki MB, 2009, ANN NEUROL, V66, P771, DOI 10.1002/ana.21715 Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265 Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e Roullet FI, 2011, BEHAV BRAIN RES, V216, P19, DOI 10.1016/j.bbr.2010.06.004 SCHAIN RJ, 1961, J PEDIATR-US, V58, P315, DOI 10.1016/S0022-3476(61)80261-8 Shi Y, 2006, J NEUROSCI, V26, P1813, DOI 10.1523/JNEUROSCI.4091-05.2006 Shmelkov SV, 2010, NAT MED, V16, P598, DOI 10.1038/nm.2125 Silverman JL, 2010, NAT REV NEUROSCI, V11, P490, DOI 10.1038/nrn2851 Steele AD, 2007, P NATL ACAD SCI USA, V104, P1983, DOI 10.1073/pnas.0610779104 Tabuchi K, 2007, SCIENCE, V318, P71, DOI 10.1126/science.1146221 Takayanagi Y, 2005, P NATL ACAD SCI USA, V102, P16096, DOI 10.1073/pnas.0505312102 Tobin VA, 2010, NATURE, V464, P413, DOI 10.1038/nature08826 Waterhouse L, 1996, J AUTISM DEV DISORD, V26, P59, DOI 10.1007/BF02276235 Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974 Weiss LA, 2006, HUM GENET, V120, P93, DOI 10.1007/s00439-006-0196-z Weiss LA, 2005, AM J HUM GENET, V76, P33, DOI 10.1086/426697 Weiss LA, 2004, EUR J HUM GENET, V12, P949, DOI 10.1038/sj.ejhg.5201239 Weiss LA, 2006, EUR J HUM GENET, V14, P923, DOI 10.1038/sj.ejhg.5201644 Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104 Wermter AK, 2010, AM J MED GENET B, V153B, P629, DOI 10.1002/ajmg.b.31032 Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013 Yang M, 2009, CURRENT PROTOCOLS NE, V48 YANG M, 2001, BEHAV NEUROSCI, V1, P1 Young DM, 2010, P NATL ACAD SCI USA, V107, P11074, DOI 10.1073/pnas.1005620107 Zhao Y, 2010, MOL PSYCHIATR, V15, P286, DOI 10.1038/mp.2009.51 NR 97 TC 30 Z9 30 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2011 VL 4 IS 1 SI SI BP 57 EP 67 DI 10.1002/aur.180 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 729JP UT WOS:000287945900006 PM 21254450 ER PT J AU Eagleson, KL Campbell, DB Thompson, BL Bergman, MY Levitt, P AF Eagleson, Kathie L. Campbell, Daniel B. Thompson, Barbara L. Bergman, Mica Y. Levitt, Pat TI The Autism Risk Genes MET and PLAUR Differentially Impact Cortical Development SO AUTISM RESEARCH LA English DT Article DE animal models; developmental neurobiology; neuroanatomy ID HEPATOCYTE GROWTH-FACTOR; FACTOR SCATTER FACTOR; MULTIFUNCTIONAL DOCKING SITE; MEDIAL GANGLIONIC EMINENCE; RECEPTOR TYROSINE KINASE; RAT VISUAL-CORTEX; C-MET; PLASMINOGEN-ACTIVATOR; FACTOR/SCATTER FACTOR; SPECTRUM DISORDERS AB Candidate risk genes for autism spectrum disorder (ASD) have been identified, but the challenge of determining their contribution to pathogenesis remains. We previously identified two ASD risk genes encoding the receptor tyrosine kinase MET and the urokinase plasminogen activator receptor (PLAUR), which is thought to modulate availability of the MET ligand. We also reported a role for Met signaling in cortical interneuron development in vitro and a reduction of these neurons in uPAR (mouse ortholog of PLAUR) null mice, suggesting that disruption of either gene impacts cortical development similarly. Here, we modify this conclusion, reporting that interneuron numbers are unchanged in the neocortex of Met(fx/fx)/ Dlx5/6(cre) mice, in which Met is ablated from cells arising from the ventral telencephalon (VTel). Consistent with this, Met transcript is not detected in the VTel during interneuron genesis and migration; furthermore, during the postnatal period of interneuron maturation, Met is co-expressed in glutamatergic projection neurons, but not interneurons. Low levels of Met protein are expressed in the VTel at E12.5 and E14.5, likely reflecting the arrival of Met-containing corticofugal axons. Met expression, however, is induced in E12.5 VTel cells after 2 days in vitro, perhaps underlying discrepancies between observations in vitro and in Met(fx/fx)/ Dlx5/6(cre) mice. We suggest that, in vivo, Met impacts the development of cortical projection neurons, whereas uPAR influences interneuron maturation. An altered balance between excitation and inhibition has been postulated as a biological mechanism for ASD; this imbalance could arise from different risk genes differentially affecting either or both elements. C1 [Eagleson, Kathie L.; Campbell, Daniel B.; Thompson, Barbara L.; Bergman, Mica Y.; Levitt, Pat] Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90033 USA. [Eagleson, Kathie L.; Thompson, Barbara L.; Levitt, Pat] Univ So Calif, Keck Sch Med, Dept Cell & Neurobiol, Los Angeles, CA 90033 USA. [Campbell, Daniel B.] Univ So Calif, Keck Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90033 USA. [Bergman, Mica Y.] Vanderbilt Univ, Med Ctr, Grad Program Neurosci, Nashville, TN USA. [Bergman, Mica Y.] Vanderbilt Univ, Med Ctr, Med Scientist Training Program, Nashville, TN USA. RP Eagleson, KL (reprint author), Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, 1501 San Pablo St,Rm 231, Los Angeles, CA 90033 USA. EM keagleso@usc.edu FU National Institutes of Health/National Institute of Mental Health [R01 MH067842, F30 MH083474] FX Grant sponsor: National Institutes of Health/National Institute of Mental Health; Grant numbers: R01 MH067842; F30 MH083474. CR ABERCROMBIE M, 1946, ANAT REC, V94, P239, DOI 10.1002/ar.1090940210 Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Anderson SA, 1997, SCIENCE, V278, P474, DOI 10.1126/science.278.5337.474 Anderson SA, 2001, DEVELOPMENT, V128, P353 Bahi A, 2006, J NEUROCHEM, V98, P1619, DOI 10.1111/j.1471-4159.2006.04013.x Beilmann M, 2000, BLOOD, V95, P3964 Berghuis P, 2004, EUR J NEUROSCI, V20, P1290, DOI 10.1111/j.1460-9568.2004.03561.x Bill BR, 2009, CURR OPIN GENET DEV, V19, P271, DOI 10.1016/j.gde.2009.04.004 Binder BR, 2007, THROMB HAEMOSTASIS, V97, P336, DOI 10.1160/TH06-11-0669 Birchmeier C, 2003, NAT REV MOL CELL BIO, V4, P915, DOI 10.1038/nrm1261 Bissonette GB, 2010, J NEUROSCI, V30, P2918, DOI 10.1523/JNEUROSCI.5268-09.2010 BLADT F, 1995, NATURE, V376, P768, DOI 10.1038/376768a0 BLASI F, 1993, BIOESSAYS, V15, P105, DOI 10.1002/bies.950150206 Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103 Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180 Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27 Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552 Cellerino A, 1996, EUR J NEUROSCI, V8, P1190, DOI 10.1111/j.1460-9568.1996.tb01287.x Colombo ES, 2007, INVEST OPHTH VIS SCI, V48, P1793, DOI 10.1167/iovs.06-0923 Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001 Del Bigio MR, 1999, INT J DEV NEUROSCI, V17, P387, DOI 10.1016/S0736-5748(99)00031-3 DENT MAR, 1993, EUR J NEUROSCI, V5, P633, DOI 10.1111/j.1460-9568.1993.tb00529.x Eagleson KL, 2010, NEUROSCIENCE, V168, P797, DOI 10.1016/j.neuroscience.2010.03.066 Eagleson KL, 2005, J COMP NEUROL, V489, P449, DOI 10.1002/cne.20647 Ebens A, 1996, NEURON, V17, P1157, DOI 10.1016/S0896-6273(00)80247-0 Eckerich C, 2007, INT J CANCER, V121, P276, DOI 10.1002/ijc.22679 El-Fishawy P, 2010, PSYCHIAT CLIN N AM, V33, P83, DOI 10.1016/j.psc.2009.12.002 Frith C, 2004, LANCET NEUROL, V3, P577, DOI 10.1016/S1474-4422(04)00875-0 Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009 Geschwind DH, 2009, ANNU REV MED, V60, P367, DOI 10.1146/annurev.med.60.053107.121225 Giacobini P, 2007, J NEUROSCI, V27, P431, DOI 10.1523/JNEUROSCI.4979-06.2007 Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618 Gorba T, 1999, EUR J NEUROSCI, V11, P1179, DOI 10.1046/j.1460-9568.1999.00551.x Hara S, 2006, ORAL ONCOL, V42, P593, DOI 10.1016/j.oraloncology.2005.10.016 Hayashi M, 2005, ENDOCRINOLOGY, V146, P4682, DOI 10.1210/en.2005-0416 Huang ZJ, 1999, CELL, V98, P739, DOI 10.1016/S0092-8674(00)81509-3 Huh CG, 2004, P NATL ACAD SCI USA, V101, P4477, DOI 10.1073/pnas.0306068101 Ide T, 2006, INT J CANCER, V119, P2750, DOI 10.1002/ijc.22178 Ide T, 2007, ANN SURG ONCOL, V14, P2600, DOI 10.1245/s10434-007-9435-3 Jackson PB, 2009, AUTISM RES, V2, P232, DOI 10.1002/aur.87 JOANNIDIS M, 1994, AM J PHYSIOL, V267, pF231 Judson MC, 2009, J COMP NEUROL, V513, P511, DOI 10.1002/cne.21969 Judson MC, 2010, J COMP NEUROL, V518, P4463, DOI 10.1002/cne.22467 Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Jyonouchi H, 2005, NEUROPSYCHOBIOLOGY, V51, P77, DOI 10.1159/000084164 Kinney DK, 2008, NEUROSCI BIOBEHAV R, V32, P1519, DOI 10.1016/j.neubiorev.2008.06.004 Kirchhofer D, 2004, J BIOL CHEM, V279, P39915, DOI 10.1074/jbc.M404795200 Kitamura K, 2007, J NEUROSCI RES, V85, P2332, DOI 10.1002/jnr.21372 Koga F, 2007, CELL CYCLE, V6, P1393 Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326 Lahtinen L, 2009, NEUROSCIENCE, V163, P316, DOI 10.1016/j.neuroscience.2009.06.019 Lalive PH, 2005, EUR J IMMUNOL, V35, P727, DOI 10.1002/eji.200425430 Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123 Larsson HJ, 2005, AM J EPIDEMIOL, V161, P926, DOI DOI 10.1093/AJE/KWI123 Lavdas AA, 1999, J NEUROSCI, V19, P7881 Levitt P, 2004, TRENDS NEUROSCI, V27, P400, DOI 10.1016/j.tins.2004.05.008 Levitt P, 2009, J CLIN INVEST, V119, P747, DOI 10.1172/JCI37934 LOKKER NA, 1992, EMBO J, V11, P2503 LONGATI P, 1994, ONCOGENE, V9, P49 Mann JR, 2010, J AUTISM DEV DISORD, V40, P548, DOI 10.1007/s10803-009-0903-4 MARS WM, 1993, AM J PATHOL, V143, P949 Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 Martins GJ, 2007, DEV NEUROSCI-BASEL, V29, P143, DOI 10.1159/000096219 Masos T, 1996, MOL BRAIN RES, V35, P139, DOI 10.1016/0169-328X(95)00199-3 MEIRI N, 1994, P NATL ACAD SCI USA, V91, P3196, DOI 10.1073/pnas.91.8.3196 Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945 Nagayama T, 2004, BRAIN RES, V999, P155, DOI 10.1016/j.braines.2003.11.052 Nakamura T, 2000, J CLIN INVEST, V106, P1511, DOI 10.1172/JCI10226 NALDINI L, 1992, EMBO J, V11, P4825 Okunishi K, 2005, J IMMUNOL, V175, P4745 Okura Y, 1999, EUR J NEUROSCI, V11, P4139, DOI 10.1046/j.1460-9568.1999.00832.x Orzechowski A, 2007, POL J VET SCI, V10, P123 Owen KA, 2010, BIOCHEM J, V426, P219, DOI 10.1042/BJ20091448 Patz S, 2004, CEREB CORTEX, V14, P342, DOI 10.1093/cercor/bhg132 Pennacchietti S, 2003, CANCER CELL, V3, P347, DOI 10.1016/S1535-6108(03)00085-0 Pleasure SJ, 2000, NEURON, V28, P727, DOI 10.1016/S0896-6273(00)00149-5 PONZETTO C, 1994, CELL, V77, P261, DOI 10.1016/0092-8674(94)90318-2 Powell EM, 2001, NEURON, V30, P79, DOI 10.1016/S0896-6273(01)00264-1 Powell EM, 2003, J NEUROSCI, V23, P622 Powell EM, 2003, DEV NEUROSCI-BASEL, V25, P197, DOI 10.1159/000072268 Rabkin R, 2001, J AM SOC NEPHROL, V12, P531 Rosova I, 2008, STEM CELLS, V26, P2173, DOI 10.1634/stemcells.2007-1104 Rubenstein JLR, 2010, CURR OPIN NEUROL, V23, P118, DOI 10.1097/WCO.0b013e328336eb13 Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Scarpino S, 2004, J PATHOL, V202, P352, DOI 10.1002/path.1522 Shimazaki K, 2003, BRAIN RES, V962, P105, DOI 10.1016/S0006-8993(02)03975-6 Sousa I, 2009, EUR J HUM GENET, V17, P749, DOI 10.1038/ejhg.2008.215 Stefan M, 2001, J BIOL CHEM, V276, P3017, DOI 10.1074/jbc.M009333200 Stenman J, 2003, J NEUROSCI, V23, P167 Sussel L, 1999, DEVELOPMENT, V126, P3359 Tang CH, 2008, CELL MOL LIFE SCI, V65, P1916, DOI 10.1007/s00018-008-7573-9 Thompson BL, 2010, J CHEM NEUROANAT, V39, P228, DOI 10.1016/j.jchemneu.2010.01.002 Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6 UEHARA Y, 1995, NATURE, V373, P702, DOI 10.1038/373702a0 Vaccarino FM, 2009, J AUTISM DEV DISORD, V39, P511, DOI 10.1007/s10803-008-0653-8 Valicenti-McDermott M, 2006, J DEV BEHAV PEDIATR, V27, pS128, DOI 10.1097/00004703-200604002-00011 van Handel M, 2007, EUR J PEDIATR, V166, P645, DOI 10.1007/s00431-007-0437-8 Wichterle H, 1999, NAT NEUROSCI, V2, P461, DOI 10.1038/8131 Wilkerson DS, 2002, INT J NEUROSCI, V112, P1085, DOI 10.1080/00207450290026076 Xiao GH, 2001, P NATL ACAD SCI USA, V98, P247, DOI 10.1073/pnas.011532898 Yoshida S, 1999, INT J MOL MED, V3, P405 NR 101 TC 18 Z9 18 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2011 VL 4 IS 1 SI SI BP 68 EP 83 DI 10.1002/aur.172 PG 16 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 729JP UT WOS:000287945900007 PM 21328570 ER PT J AU Lerer, E Levi, S Israel, S Yaari, M Nemanov, L Mankuta, D Yirmiya, N Ebstein, RP AF Lerer, Elad Levi, Shlomit Israel, Salomon Yaari, Maya Nemanov, Lubov Mankuta, David Yirmiya, Nurit Ebstein, Richard P. TI Low CD38 Expression in Lymphoblastoid Cells and Haplotypes are Both Associated with Autism in a Family-Based Study SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder (ASD); CD38; polymorphism; gene expression; real time PCR; haplotype ID PERVASIVE DEVELOPMENTAL DISORDERS; OXYTOCIN RECEPTOR OXTR; CYCLIC ADP-RIBOSE; GENOME-WIDE; SPECTRUM DISORDERS; MONOZYGOTIC TWINS; RNA EXPRESSION; GENE FAMILY; VASOPRESSIN; BEHAVIOR AB Background: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion. This prompted us to both examine CD38 expression in human lymphoblastoid cell lines (LBC) as well as to test association between SNPs across the CD38 gene and ASD. Methods: LBC's were derived from 44 ASD lines and 40 "unaffected" parents. Family-based association (UNPHASED) was examined by genotyping 11 tagging SNPs spanning the CD38 gene identified using HapMap data in 170 trios. An additional SNP (rs3796863) associated in a study by Munesue et al. with ASD was also genotyped. Results: A highly significant reduction in CD38 expression was observed in immortalized lymphocytes derived from ASD subjects compared to their "unaffected" parents (F = 17.2, P = 0.00024, df = 1). Haplotype analysis showed significant association (permutation corrected) between three and seven locus haplotypes and DSM IV ASD in low functioning (IQ<70) subjects. Conclusions: The current report supports a role for CD38 in conferring risk for ASD. Notably, our study shows that this gene is not only associated with low functioning ASD but that CD38 expression is markedly reduced in LBC derived from ASD subjects compared to "unaffected" parents, strengthening the connection between oxytocin and ASD. C1 [Ebstein, Richard P.] Natl Univ Singapore, Dept Psychol, Fac Arts & Sci, Singapore 117570, Singapore. [Israel, Salomon; Yaari, Maya; Yirmiya, Nurit; Ebstein, Richard P.] Hebrew Univ Jerusalem, Dept Psychol, IL-91905 Jerusalem, Israel. [Levi, Shlomit] Hadassah Hebrew Univ, Dept Child Psychiat, Sch Med, Jerusalem, Israel. [Nemanov, Lubov] Herzog Hosp, Jerusalem, Israel. [Mankuta, David] Hadassah Med Org, Dept Labor & Delivery, Jerusalem, Israel. [Nemanov, Lubov] S Herzog Mem Hosp, Jerusalem, Israel. RP Ebstein, RP (reprint author), Natl Univ Singapore, Dept Psychol, Fac Arts & Sci, Block AS4,9 Arts Link, Singapore 117570, Singapore. EM rpebstein@gmail.com FU Autism Speaks; Israel Ministry of Science; "Levi Eshkol" Scholarship FX We thank Autism Speaks for partial support of this research (R.P.E.) and to the "Levi Eshkol" scholarship fund for PhD studies (E.L.), Israel Ministry of Science.Grant sponsor: Autism Speaks and "Levi Eshkol" Scholarship. CR Allen-Brady K, 2009, MOL PSYCHIATR, V14, P590, DOI 10.1038/mp.2008.14 Ashwood P, 2006, J LEUKOCYTE BIOL, V80, P1, DOI 10.1189/jlb.1205707 Atladottir HO, 2009, PEDIATRICS, V124, P687, DOI 10.1542/peds.2008-2445 Baron CA, 2006, J AUTISM DEV DISORD, V36, P973, DOI 10.1007/s10803-006-0134-x Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457 Baumgartner T, 2008, NEURON, V58, P639, DOI 10.1016/j.neuron.2008.04.009 Bayley N, 1993, BAYLEY SCALES INFANT Bielsky IF, 2004, PEPTIDES, V25, P1565, DOI 10.1016/j.peptides.2004.05.019 Bruzzone S, 2004, J NEUROCHEM, V89, P264, DOI 10.1111/j.1471-4159.2003.02326.x CATTELL P, 1960, MEASUREMENT INTELLIG Chagnon YC, 2008, SCHIZOPHR RES, V100, P281, DOI 10.1016/j.schres.2007.12.471 Dantzer R, 2008, BRAIN BEHAV IMMUN, V22, P804, DOI 10.1016/j.bbi.2008.03.001 Deaglio S, 2006, BLOOD, V108, P1135, DOI 10.1182/blood-2006-01-013003 Dheda K, 2004, BIOTECHNIQUES, V37, P119 Dheda K, 2004, BIOTECHNIQUES, V37, P116 Dheda K, 2004, BIOTECHNIQUES, V37, P112 Dheda K, 2004, BIOTECHNIQUES, V37, P116 Ditzen B, 2009, BIOL PSYCHIAT, V65, P728, DOI 10.1016/j.biopsych.2008.10.011 Domes G, 2007, BIOL PSYCHIAT, V61, P731, DOI 10.1016/j.biopsych.2006.07.015 Donaldson ZR, 2008, SCIENCE, V322, P900, DOI 10.1126/science.1158668 Dudbridge F, 2003, GENET EPIDEMIOL, V25, P115, DOI 10.1002/gepi.10252 Ferrero E, 1997, J IMMUNOL, V159, P3858 Fraga MF, 2005, P NATL ACAD SCI USA, V102, P10604, DOI 10.1073/pnas.0500398102 Freeman SJ, 2005, DIABETES CARE, V28, P925, DOI 10.2337/diacare.28.4.925 Gordon I, 2008, PSYCHOPHYSIOLOGY, V45, P349, DOI 10.1111/j.1469-8986.2008.00649.x Guastella A., 2007, BIOL PSYCHIAT, V63, P3 Higashida H, 2007, NEUROCHEM INT, V51, P192, DOI 10.1016/j.neuint.2007.06.023 Hoge EA, 2008, CNS NEUROSCI THER, V14, P165, DOI 10.1111/j.1755-5949.2008.00051.x Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030 Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118 Iafusco D, 2006, DIABETES CARE, V29, P1985, DOI 10.2337/dc06-0842 Insel TR, 1997, AM J PSYCHIAT, V154, P726 Israel S, 2008, PROG BRAIN RES, V170, P435, DOI 10.1016/S0079-6123(08)00434-2 Jacob S, 2007, NEUROSCI LETT, V417, P6, DOI 10.1016/j.neulet.2007.02.001 Jin D, 2007, NATURE, V446, P41, DOI 10.1038/nature05526 Kaufman AS, 1983, KAUFMAN ASSESSMENT B Kim SJ, 2002, MOL PSYCHIATR, V7, P503, DOI 10.1038/sj.mp.4001125 Kosfeld M, 2005, NATURE, V435, P673, DOI 10.1038/nature03701 Lauritsen MB, 2006, MOL PSYCHIATR, V11, P37, DOI 10.1038/sj.mp.4001754 Lee HC, 2001, ANNU REV PHARMACOL, V41, P317, DOI 10.1146/annurev.pharmtox.41.1.317 Le-Niculescu H, 2009, MOL PSYCHIATR, V14, P156, DOI 10.1038/mp.2008.11 Lerer E, 2008, MOL PSYCHIATR, V13, P980, DOI 10.1038/sj.mp.4002087 Levine Ari, 2007, Peptides, V28, P1162, DOI 10.1016/j.peptides.2007.04.016 Liew M, 2004, CLIN CHEM, V50, P1156, DOI 10.1373/clinchem.2004.032136 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Malavasi F, 2008, PHYSIOL REV, V88, P841, DOI 10.1152/physrev.00035.2007 Mayo L, 2008, J IMMUNOL, V181, P92 McCauley JL, 2005, BMC MED GENET, V6, DOI 10.1186/1471-2350-6-1 Meyer-Lindenberg A., 2008, MOL PSYCHIATR, V14, P968, DOI 10.1038/mp.2008.54 Modahl C, 1998, BIOL PSYCHIAT, V43, P270, DOI 10.1016/S0006-3223(97)00439-3 Mullen E., 1997, MULLEN SCALES EARLY Munesue T, 2010, NEUROSCI RES, V67, P181, DOI 10.1016/j.neures.2010.03.004 Ohtsuji M, 2008, EXP DIABETES RES, DOI 10.1155/2008/897508 Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e Roid G., 1997, LEITER INT PERFORMAN Savaskan E, 2008, PSYCHONEUROENDOCRINO, V33, P368, DOI 10.1016/j.psyneuen.2007.12.004 SHAM PC, 1995, ANN HUM GENET, V59, P323, DOI 10.1111/j.1469-1809.1995.tb00751.x Sparrow S, 1984, VINELAND ADAPTIVE BE STUTSMAN R, 1948, MANUAL MERRILLPALMER Tang Y, 2005, ARCH NEUROL-CHICAGO, V62, P210, DOI 10.1001/archneur.62.2.210 Thorndike R. L., 1986, STANFORDBINET INTELL Wassink TH, 2004, MOL PSYCHIATR, V9, P968, DOI 10.1038/sj.mp.4001503 WECHSLER D, 1991, WISC 2 KIT WECHSLER Wu SP, 2005, BIOL PSYCHIAT, V58, P74, DOI 10.1016/j.biopsych.2005.03.013 Yagui K, 1998, DIABETOLOGIA, V41, P1024, DOI 10.1007/s001250051026 Yamada M, 1997, BRAIN RES, V756, P52, DOI 10.1016/S0006-8993(97)00117-0 Yirmiya N, 2006, MOL PSYCHIATR, V11, P488, DOI 10.1038/sj.mp.4001812 Yrigollen CM, 2008, BIOL PSYCHIAT, V63, P911, DOI 10.1016/j.biopsych.2007.11.015 Zak PJ, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001128 NR 70 TC 35 Z9 35 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2010 VL 3 IS 6 BP 293 EP 302 DI 10.1002/aur.156 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 707QJ UT WOS:000286300800001 PM 21182206 ER PT J AU Salyakina, D Ma, DQ Jaworski, JM Konidari, I Whitehead, PL Henson, R Martinez, D Robinson, JL Sacharow, S Wright, HH Abramson, RK Gilbert, JR Cuccaro, ML Pericak-Vance, MA AF Salyakina, D. Ma, D. Q. Jaworski, J. M. Konidari, I. Whitehead, P. L. Henson, R. Martinez, D. Robinson, J. L. Sacharow, S. Wright, H. H. Abramson, R. K. Gilbert, J. R. Cuccaro, M. L. Pericak-Vance, M. A. TI Variants in Several Genomic Regions Associated with Asperger Disorder SO AUTISM RESEARCH LA English DT Article DE asperger; susceptibility; genetics ID AUTISM SPECTRUM DISORDERS; WIDE ASSOCIATION; LINKAGE ANALYSES; CHROMOSOME; FAMILIES; GENE; GFR-ALPHA-1; IMPAIRMENT; BEHAVIORS; EXTENSION AB Asperger disorder (ASP) is one of the autism spectrum disorders (ASD) and is differentiated from autism largely on the absence of clinically significant cognitive and language delays. Analysis of a homogenous subset of families with ASP may help to address the corresponding effect of genetic heterogeneity on identifying ASD genetic risk factors. To examine the hypothesis that common variation is important in ASD, we performed a genome-wide association study (GWAS) in 124 ASP families in a discovery data set and 110 ASP families in a validation data set. We prioritized the top 100 association results from both cohorts by employing a ranking strategy. Novel regions on 5q21.1 (P= 9.7 x 10(-7)) and 15q22.1-q22.2 (P = 7.3 x 10(-6)) were our most significant findings in the combined data set. Three chromosomal regions showing association, 3p14.2 (P= 3.6 x 10(-6)), 3q25-26 (P= 6.0 x 10(-5)) and 3p23 (P= 3.3 x 10(-4)) overlapped linkage regions reported in Finnish ASP families, and eight association regions overlapped ASD linkage areas. Our findings suggest that ASP shares both ASD-related genetic risk factors, as well as has genetic risk factors unique to the ASP phenotype. C1 [Pericak-Vance, M. A.] Univ Miami, Miller Sch Med, Dr John T Macdonald Fdn, John P Hussman Inst Human Genom, Miami, FL 33136 USA. [Salyakina, D.; Ma, D. Q.; Jaworski, J. M.; Konidari, I.; Whitehead, P. L.; Henson, R.; Martinez, D.; Robinson, J. L.; Sacharow, S.; Gilbert, J. R.; Cuccaro, M. L.; Pericak-Vance, M. A.] Univ Miami, Miller Sch Med, Dr John T Macdonald Fdn, Dept Human Genet, Miami, FL 33136 USA. [Wright, H. H.; Abramson, R. K.] Univ S Carolina, Sch Med, Dept Neuropsychiat, Columbia, SC USA. RP Pericak-Vance, MA (reprint author), Univ Miami, Miller Sch Med, Dr John T Macdonald Fdn, John P Hussman Inst Human Genom, 1501 NW 10th Ave,BRB-314,M860, Miami, FL 33136 USA. EM mpericak@med.miami.edu FU National Institutes of Health (NIH) [NS26630, MH080647]; Autism Speaks; Hussman Foundation FX Grant sponsor: National Institutes of Health (NIH); Grant numbers: NS26630; MH080647; Grant sponsor: Autism Speaks.We thank the patients with Asperger disorder and their family members who participated in this study and the personnel at the John P. Hussman Institute for Human Genomics (HIHG), including the staff at the HIHG Biorepository and members of the HIHG. We also thank Michael Schmidt and Susan Slifer for their contributions to the data analysis and simulation. This research was supported by a gift from the Hussman Foundation. We also wish to gratefully acknowledge the resources provided by the AGRE consortium and the participating Autism Genetic Resource Exchange (AGRE) families. The AGRE resource is supported by Autism Speaks. A subset of the participants was ascertained while Dr. Pericak-Vance was a faculty member at Duke University. CR Alarcon M, 2005, MOL PSYCHIATR, V10, P747, DOI 10.1038/sj.mp.4001666 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P73 Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457 BAUMAN M, 1985, NEUROLOGY, V35, P866 Bennett T, 2008, J AUTISM DEV DISORD, V38, P616, DOI 10.1007/s10803-007-0428-7 Birney E, 2007, NATURE, V447, P799, DOI 10.1038/nature05874 Buxbaum JD, 2004, MOL PSYCHIATR, V9, P144, DOI 10.1038/sj.mp.4001465 Cacalano G, 1998, NEURON, V21, P53, DOI 10.1016/S0896-6273(00)80514-0 Chung RH, 2006, HUM HERED, V61, P189, DOI 10.1159/000094774 Chung RH, 2007, AM J HUM GENET, V80, P59, DOI 10.1086/510630 Chung RH, 2010, GENET EPIDEMIOL, V34, P747, DOI 10.1002/gepi.20539 Dudbridge F, 2008, GENET EPIDEMIOL, V32, P227, DOI 10.1002/gepi.20297 FISHER RA, 1925, STAT METHODS RES WOR, P99 Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896 Gabis L, 2008, J CHILD NEUROL, V23, P766, DOI 10.1177/0883073808315423 *INT MULT SCLER GE, 2007, RISK ALL MULT SCLER, P357 Palferman S, 2001, HUM MOL GENET, V10, P973 Palferman S, 2001, AM J HUM GENET, V69, P570 Kleinhans NM, 2009, J AUTISM DEV DISORD, V39, P1079, DOI 10.1007/s10803-009-0707-6 Kleinjan DA, 2006, DEV BIOL, V299, P563, DOI 10.1016/j.ydbio.2006.08.060 Lamb JA, 2005, J MED GENET, V42, P132, DOI 10.1136/jmg.2004.025668 Liu XQ, 2008, BIOL PSYCHIAT, V64, P561, DOI 10.1016/j.biopsych.2008.05.023 Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x Marchini J, 2007, NAT GENET, V39, P906, DOI 10.1038/ng2088 Mattila ML, 2007, J AM ACAD CHILD PSY, V46, P636, DOI 10.1097/chi.0b013e318033ff42 Moriguchi S, 2006, P NATL ACAD SCI USA, V103, P10811, DOI 10.1073/pnas.0509863103 Pozas E, 2005, NEURON, V45, P701, DOI 10.1016/j.neuron.2005.01.043 Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795 REHNSTROM K, 2006, J MED GENET, V43, pNI134, DOI DOI 10.1136/JMG.2005.033621 RITVO ER, 1986, AM J PSYCHIAT, V143, P862 Rodier PM, 1996, J COMP NEUROL, V370, P247, DOI 10.1002/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2 Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d Rutter M., 2003, AUTISM DIAGNOSTIC IN Saitoh O, 2001, BRAIN, V124, P1317, DOI 10.1093/brain/124.7.1317 Samad TA, 2005, J BIOL CHEM, V280, P14122, DOI 10.1074/jbc.M410034200 Schmidt M, 2005, STAT APPL GENET MO B, V4, DOI 10.2202/1544-6115.1133 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 STRUYK AF, 1995, J NEUROSCI, V15, P2141 Su AI, 2002, P NATL ACAD SCI USA, V99, P4465, DOI 10.1073/pnas.012025199 Frazer KA, 2007, NATURE, V449, P851, DOI 10.1038/nature06258 Vourc'h P, 2003, PSYCHIAT GENET, V13, P221, DOI 10.1097/01.ypg.0000084946.07075.37 Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Wang Y, 2000, J BIOL CHEM, V275, P20033, DOI 10.1074/jbc.M909008199 Williams E, 2008, DEV MED CHILD NEUROL, V50, P672, DOI 10.1111/j.1469-8749.2008.03042.x Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2 Woodbury-Smith MR, 2009, EUR CHILD ADOLES PSY, V18, P2, DOI 10.1007/s00787-008-0701-0 World Health Organisation, 1992, ICD 10 CLASS MENT BE Ylisaukko-oja T, 2006, ANN NEUROL, V59, P145, DOI 10.1002/ana.20722 YLISAUKKOOJA T, 2004, MOL PSYCHIATR, V8, P879 NR 52 TC 11 Z9 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2010 VL 3 IS 6 BP 303 EP 310 DI 10.1002/aur.158 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 707QJ UT WOS:000286300800002 PM 21182207 ER PT J AU de Marchena, A Eigsti, IM AF de Marchena, Ashley Eigsti, Inge-Marie TI Conversational Gestures in Autism Spectrum Disorders: Asynchrony but not Decreased Frequency SO AUTISM RESEARCH LA English DT Article DE conversational gestures; autism; synchrony; communication; narratives ID PERVASIVE DEVELOPMENTAL DISORDERS; JOINT ATTENTION; YOUNG-CHILDREN; COMMUNICATIVE DEVELOPMENT; NONVERBAL-COMMUNICATION; SENTENCE COMPREHENSION; LANGUAGE-DEVELOPMENT; HAND GESTURES; SPEECH; CEREBELLUM AB Conversational or "co-speech" gestures play an important role in communication, facilitating turntaking, providing visuospatial information, clarifying subtleties of emphasis, and other pragmatic cues. Consistent with other pragmatic language deficits, individuals with autism spectrum disorders (ASD) are said to produce fewer conversational gestures, as specified in many diagnostic measures. Surprisingly, while research shows fewer deictic gestures in young children with ASD, there is a little empirical evidence addressing other forms of gesture. The discrepancy between clinical and empirical observations may reflect impairments unrelated to frequency, such as gesture quality or integration with speech. Adolescents with high-functioning ASD (n = 15), matched on age, gender, and IQ to 15 typically developing (TO) adolescents, completed a narrative task to assess the spontaneous production of speech and gesture. Naive observers rated the stories for communicative quality. Overall, the ASD group's stories were rated as less clear and engaging. Although utterance and gesture rates were comparable, the ASD group's gestures were less closely synchronized with the co-occurring speech, relative to control participants. This gesture speech synchrony specifically impacted communicative quality across participants. Furthermore, while story ratings were associated with gesture count in TD adolescents, no such relationship was observed in adolescents with ASD, suggesting that gestures do not amplify communication in this population. Quality ratings were, however, correlated with ASD symptom severity scores, such that participants with fewer ASD symptoms were rated as telling higher quality stories. Implications of these findings are discussed in terms of communication and neuropsychological functioning in ASD. C1 [Eigsti, Inge-Marie] Univ Connecticut, Unit 1020, Dept Psychol, Storrs, CT 06269 USA. RP Eigsti, IM (reprint author), Univ Connecticut, Unit 1020, Dept Psychol, 406 Babbidge Rd, Storrs, CT 06269 USA. EM inge-marie.eigsti@uconn.edu FU University of Connecticut Research Foundation [458938] FX Grant sponsor: University of Connecticut Research Foundation; Grant number: 458938. CR ACKERMANN H, 2004, NEUROSCIENCE REV, V3, P14 Allen G., 2005, CLIN NEUROPSYCHIATRY, V2, P321 (APA) APA, 2000, DIAGN STAT MAN MENT Asperger H, 1944, ARCH PSYCHIAT NERVEN, V117, P76, DOI 10.1007/BF01837709 Attwood HH, 1988, J AUTISM DEV DISORD, V18, P241 BARONCOHEN S, 1989, BRIT J DEV PSYCHOL, V7, P113 BARONCOHEN S, 1986, BRIT J DEV PSYCHOL, V4, P113 BARTAK L, 1975, BRIT J PSYCHIAT, V126, P127, DOI 10.1192/bjp.126.2.127 BEATTIE G, 1994, SEMIOTICA, V99, P239, DOI 10.1515/semi.1994.99.3-4.239 Bebko JM, 2006, J CHILD PSYCHOL PSYC, V47, P88, DOI 10.1111/j.1469-7610.2005.01443.x Bono MA, 2004, J AUTISM DEV DISORD, V34, P495, DOI 10.1007/s10803-004-2545-x BUCK R, 1980, CORTEX, V16, P351 Camaioni L, 1997, J AUTISM DEV DISORD, V27, P715, DOI 10.1023/A:1025858917000 Capps L., 1998, AUTISM, V2, P325, DOI DOI 10.1177/1362361398024002 Cassell J., 1998, PRAGMAT COGN, V6, P1 CHARLOP MH, 1985, J APPL BEHAV ANAL, V18, P155, DOI 10.1901/jaba.1985.18-155 Charman T, 2003, J CHILD LANG, V30, P213, DOI 10.1017/S0305000902005482 Choi SH, 2001, EXP BRAIN RES, V139, P311, DOI 10.1007/s002210100777 Chu MY, 2008, J EXP PSYCHOL GEN, V137, P706, DOI 10.1037/a0013157 Chugani DC, 1999, PROG NEURO-PSYCHOPH, V23, P635, DOI 10.1016/S0278-5846(99)00022-6 Chui K, 2005, J PRAGMATICS, V37, P871, DOI 10.1016/j.pragma.2004.10.016 Colgan SE, 2006, CHILD NEUROPSYCHOL, V12, P307, DOI 10.1080/09297040600701360 COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102 DIEHL JJ, 2006, J ABNORMAL CHILD PSY, V0034 Fatemi SH, 2002, CELL MOL NEUROBIOL, V22, P171, DOI 10.1023/A:1019861721160 Garcia-Perez RM, 2007, J AUTISM DEV DISORD, V37, P1310, DOI 10.1007/s10803-006-0276-x Glickstein M, 2006, BRAIN, V129, P288, DOI 10.1093/brain/awh728 Gough PM, 2005, J NEUROSCI, V25, P8010, DOI 10.1523/JNEUROSCI.2307-05.2005 Habets B, 2011, J COGNITIVE NEUROSCI, V23, P1845, DOI 10.1162/jocn.2010.21462 Harris GJ, 2006, BRAIN COGNITION, V61, P54, DOI 10.1016/j.bandc.2005.12.015 Heilman K.M., 2003, CLIN NEUROPSYCHOLOGY, P215 Higuchi S, 2007, CORTEX, V43, P350, DOI 10.1016/S0010-9452(08)70460-X Hobson RP, 1998, J AUTISM DEV DISORD, V28, P117, DOI 10.1023/A:1026088531558 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Kanner L, 1943, NERV CHILD, V2, P217 Katz Donald B, 2002, Behav Cogn Neurosci Rev, V1, P229, DOI 10.1177/1534582302001003004 Kita S., 2000, LANGUAGE GESTURE, P162, DOI DOI 10.1017/CBO9780511620850.011 Kita S, 2003, J MEM LANG, V48, P16, DOI 10.1016/S0749-596X(02)00505-3 Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895 Knaus TA, 2008, J INT NEUROPSYCH SOC, V14, P967, DOI 10.1017/S1355617708081216 KRAUSS RM, 1991, J PERS SOC PSYCHOL, V61, P743, DOI 10.1037/0022-3514.61.5.743 LEVELT WJM, 1985, J MEM LANG, V24, P133, DOI 10.1016/0749-596X(85)90021-X Loehr D., 2007, GESTURE, V7, P179, DOI [10.1075/gest.7.2.04loe, DOI 10.1075/GEST.7.2.04LOE] LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C., 2002, AUTISM DIAGNOSTIC OB LOVELAND KA, 1986, J AUTISM DEV DISORD, V16, P335, DOI 10.1007/BF01531663 Luyster R, 2007, J CHILD LANG, V34, P623, DOI 10.1017/S0305000907008094 MacWhinney B., 2000, CHILDES PROJECT TOOL MCCORMICK DA, 1984, J NEUROSCI, V4, P2811 McNeill D., 1992, HAND MIND WHAT GESTU McNeill D., 2005, GESTURE AND THOUGHT McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x MORRELSAMUELS P, 1992, J EXP PSYCHOL LEARN, V18, P615, DOI 10.1037/0278-7393.18.3.615 MUNDY P, 1986, J CHILD PSYCHOL PSYC, V27, P657, DOI 10.1111/j.1469-7610.1986.tb00190.x MUNDY P, 1990, J AUTISM DEV DISORD, V20, P115, DOI 10.1007/BF02206861 Nishitani N, 2005, PHYSIOLOGY, V20, P60, DOI 10.1152/physiol.00043.2004 Nobe S, 2000, LANGUAGE GESTURE, P186, DOI 10.1017/CBO9780511620850.012 Noldus LPJJ, 2000, BEHAV RES METH INS C, V32, P197, DOI 10.3758/BF03200802 Oberman LM, 2009, DEVELOPMENTAL SCI, V12, P510, DOI 10.1111/j.1467-7687.2008.00796.x Otsuka H, 1999, NEURORADIOLOGY, V41, P517 RITVO ER, 1986, AM J PSYCHIAT, V143, P862 Robins DL, 2001, J AUTISM DEV DISORD, V31, P131, DOI 10.1023/A:1010738829569 Roid G., 2003, STANFORDBINET INTELL, VFifth Rutter M., 2003, SOCIAL COMMUNICATION SEARS LL, 1994, J AUTISM DEV DISORD, V24, P737, DOI 10.1007/BF02172283 Silverman LB, 2010, COGNITION, V115, P380, DOI 10.1016/j.cognition.2010.01.002 Skipper JI, 2007, BRAIN LANG, V101, P260, DOI 10.1016/j.bandl.2007.02.008 Smith EG, 2007, J CHILD PSYCHOL PSYC, V48, P813, DOI 10.1111/j.1469-7610.2007.01766.x Stefanini S, 2007, BRAIN LANG, V101, P208, DOI 10.1016/j.bandl.2007.01.005 TANTAM D, 1993, J AUTISM DEV DISORD, V23, P111, DOI 10.1007/BF01066422 THAL D, 1992, J SPEECH HEAR RES, V34, P1281 Webb SJ, 2006, J AUTISM DEV DISORD, V36, P881, DOI 10.1007/s10803-006-0126-x WETHERBY AM, 1984, J SPEECH HEAR RES, V27, P364 WING L, 1981, PSYCHOL MED, V11, P115 NR 75 TC 8 Z9 8 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2010 VL 3 IS 6 BP 311 EP 322 DI 10.1002/aur.159 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 707QJ UT WOS:000286300800003 PM 21182208 ER PT J AU Grether, JK Croen, LA Anderson, MC Nelson, KB Yolken, RH AF Grether, Judith K. Croen, Lisa A. Anderson, Meredith C. Nelson, Karin B. Yolken, Robert H. TI Neonatally Measured Immunoglobulins and Risk of Autism SO AUTISM RESEARCH LA English DT Article DE autism; ASD; maternal immune function; immunoglobulins and pregnancy ID CONGENITAL CYTOMEGALOVIRUS-INFECTION; MATERNAL INFLUENZA INFECTION; SPECTRUM DISORDERS; AUTOIMMUNE-DISEASES; CHILDREN; BRAIN; ASSOCIATION; PREVALENCE; PREGNANCY; PSYCHOSIS AB Previous studies indicate that prenatal exposure to infections is a possible pathway through which autism spectrum disorders (ASD) could be initiated. We investigated whether immunoglobulin levels in archived specimens obtained from newborns subsequently diagnosed with ASD are different from levels in newborn specimens from controls. Children with ASD born in six California counties in 1994 were ascertained through records of the California Department of Developmental Services (DDS) and Kaiser Permanente; controls were randomly selected using birth certificates. Archived newborn blood specimens were obtained from the California Genetic Disease Screening Program (GDSP) for N=213 cases and N=265 controls and assayed to determine levels of total IgG, antigen-specific IgG to selected common pathogens, total IgM, total IgA, and C-reactive protein (CRP). We did not find measurable levels of total IgM or IgA in any neonate and measurable CRP was present in only a few. No antigen-specific IgG antibodies were elevated in cases compared to controls and total IgG levels were lower. In adjusted models, a 10-unit increase in total IgG yielded an OR = 0.72 (950/0 Cl 0.56, 0.91); a significantly decreasing trend in risk of ASD was observed across increasing exposure quartiles of total IgG (P=0.01). The finding of lower IgG in cases may indicate maternal immune dysfunction during gestation and/or impaired transplacental transfer of immunoglobulins. Further investigation of IgG levels in newborns and the mechanisms by which they might be associated with ASD are warranted. C1 [Grether, Judith K.; Anderson, Meredith C.] Calif Dept Publ Hlth, Richmond, CA 94804 USA. [Croen, Lisa A.] Kaiser Permanente No Calif, Div Res, Oakland, CA USA. [Nelson, Karin B.] NINDS, Bethesda, MD 20892 USA. [Yolken, Robert H.] Johns Hopkins Sch Med, Stanley Neurovirol Lab, Dept Pediat, Baltimore, MD USA. RP Grether, JK (reprint author), Calif Dept Publ Hlth, 850 Marina Bay Pkwy, Richmond, CA 94804 USA. EM judith.grether@cdph.ca.gov FU Stanley Medical Research Institute, The Centers for Disease Control and Prevention [CDC U10/CCU920392]; California Department of Public Health FX Grant sponsor: Stanley Medical Research Institute, The Centers for Disease Control and Prevention; Grant number: CDC U10/CCU920392; Grant sponsor: California Department of Public Health. CR Arndt TL, 2005, INT J DEV NEUROSCI, V23, P189, DOI 10.1016/j.ijdevneu.2004.11.001 Atladottir HO, 2010, ARCH PEDIAT ADOL MED, V164, P470, DOI 10.1001/archpediatrics.2010.9 Atladottir HO, 2009, PEDIATRICS, V124, P687, DOI 10.1542/peds.2008-2445 BAILEY A, 1995, PSYCHOL MED, V25, P63 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Buka SL, 2001, ARCH GEN PSYCHIAT, V58, P1032, DOI 10.1001/archpsyc.58.11.1032 Buka SL, 2001, BRAIN BEHAV IMMUN, V15, P411, DOI 10.1006/brbi.2001.0644 CHESS S, 1971, J AUTISM CHILD SCHIZ, V1, P33, DOI 10.1007/BF01537741 Cicarelli LM, 2005, MEDIAT INFLAMM, P96, DOI 10.1155/MI.2005.96 Cohly HHP, 2005, INT REV NEUROBIOL, V71, P317, DOI 10.1016/S0074-7742(05)71013-8 Croen Lisa A, 2008, Am J Obstet Gynecol, V199, DOI 10.1016/j.ajog.2008.04.044 Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880 Croen LA, 2005, ARCH PEDIAT ADOL MED, V159, P151, DOI 10.1001/archpedi.159.2.151 Croen LA, 2008, BIOL PSYCHIAT, V64, P583, DOI 10.1016/j.biopsych.2008.05.006 Croonenberghs J, 2002, PSYCHOL MED, V32, P1457, DOI 10.1017/S0033291702006037 DEYKIN EY, 1979, AM J EPIDEMIOL, V109, P628 Ellman LM, 2009, BIOL PSYCHIAT, V65, P1040, DOI 10.1016/j.biopsych.2008.12.015 ENSTROM A, 2008, BRAIN BEHAV IMM 1225 Fatemi SH, 2005, SYNAPSE, V57, P91, DOI 10.1002/syn.20162 FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x Fombonne E, 2003, JAMA-J AM MED ASSOC, V289, P87, DOI 10.1001/jama.289.1.87 Gilmore JH, 2005, J NEUROIMMUNOL, V159, P106, DOI 10.1016/j.jneuroim.2004.10.008 Goines P, 2010, CURR OPIN NEUROL, V23, P111, DOI 10.1097/WCO.0b013e3283373514 Grimbacher B, 2004, CURR ALLERGY ASTHM R, V4, P349, DOI 10.1007/s11882-004-0083-4 Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483 Heuer L, 2008, AUTISM RES, V1, P275, DOI 10.1002/aur.42 Korvatska E, 2002, NEUROBIOL DIS, V9, P107, DOI 10.1006/nbdi.2002.0479 KRIEGER N, 1992, AM J PUBLIC HEALTH, V82, P703, DOI 10.2105/AJPH.82.5.703 MARKOWITZ PI, 1983, J AUTISM DEV DISORD, V13, P249, DOI 10.1007/BF01531564 Mortensen Preben Bo, 2007, Biol Psychiatry, V61, P688, DOI 10.1016/j.biopsych.2006.05.024 RAMAN L, 1981, INDIAN J PEDIATR, V49, P263 RITVO ER, 1985, AM J PSYCHIAT, V142, P74 Rosen NJ, 2007, PEDIATRICS, V119, pE61, DOI 10.1542/peds.2006-1788 Schendel D, 2008, PEDIATRICS, V121, P1155, DOI 10.1542/peds.2007-1049 Shi LM, 2009, BRAIN BEHAV IMMUN, V23, P116, DOI 10.1016/j.bbi.2008.07.012 Shi LM, 2005, INT J DEV NEUROSCI, V23, P299, DOI 10.1016/j.ijdevneu.2004.05.005 Shi LM, 2003, J NEUROSCI, V23, P297 Simister NE, 2003, VACCINE, V21, P3365, DOI 10.1016/S0264-410X(03)00334-7 STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x Stites D P, 1975, Acta Endocrinol Suppl (Copenh), V194, P306 STUBBS EG, 1984, J AUTISM DEV DISORD, V14, P183, DOI 10.1007/BF02409660 Trajkovski V, 2004, CROAT MED J, V45, P746 Verboon-Maciolek MA, 2006, PEDIATR RES, V59, P457, DOI 10.1203/01.pdr.0000200808.35368.57 Wing L, 2002, MENT RETARD DEV D R, V8, P151, DOI 10.1002/mrdd.10029 Yamashita Y, 2003, J AUTISM DEV DISORD, V33, P455, DOI 10.1023/A:1025023131029 NR 45 TC 11 Z9 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2010 VL 3 IS 6 BP 323 EP 332 DI 10.1002/aur.160 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 707QJ UT WOS:000286300800004 PM 21182209 ER PT J AU Keita, L Mottron, L Bertone, A AF Keita, Luc Mottron, Laurent Bertone, Armando TI Far Visual Acuity is Unremarkable in Autism: Do We Need to Focus on Crowding? SO AUTISM RESEARCH LA English DT Article DE autism; vision; acuity; crowding; neural; lateral interactions ID SPECTRUM DISORDERS; PERCEPTION; ATTENTION; INDIVIDUALS; RESOLUTION; DEPENDS AB Although autism presents a unique perceptual phenotype defined in part by atypical (often enhanced) analysis of spatial information, few biologically plausible hypotheses have been advanced to explain its neural underpinnings. One plausible explanation is functional but altered lateral connectivity mediating early or local mechanisms selectively responsive to different stimulus attributes, including spatial frequency and contrast. The goal of the present study was first to assess far visual acuity in autism using Landolt-C optotypes defined by different local stimulus attributes. Second, we investigated whether acuity is differentially affected in autism when target optotypes are simultaneously presented with flanking stimuli at different distances. This typical detrimental "crowding effect" of flanking stimuli on target optotype discrimination is attributed to lateral inhibitory interaction of neurons encoding for visual properties of distracters close to the target. Results failed to demonstrate a between-group difference in acuity to Landolt-C optotypes, whether defined by luminance- or texture-contrast. However, the expected crowding effect at one gap-size opening distance was evidenced for the control group only; a small effect was observed for the autism group at two gap-size opening. These results suggest that although far visual acuity is unremarkable in autism, altered local lateral connectivity within early perceptual areas underlying spatial information processing in autism is atypical. Altered local lateral connectivity in autism might originate from an imbalance in excitatory/inhibitory neural signaling, resulting in changes regarding elementary feature extraction and subsequent downstream visual integration and visuo-spatial analysis. This notion is discussed within the context of characteristic lower- and higher-level perceptual processing in autism. C1 [Bertone, Armando] Univ Montreal, Perceptual Neurosci Lab Autism & Dev Condit, Hop Riviere des Prairies, Montreal, PQ, Canada. [Keita, Luc; Mottron, Laurent] Univ Montreal, Pervas Dev Disorders Specialized Clin, Hop Riviere des Prairies, Montreal, PQ, Canada. [Keita, Luc; Mottron, Laurent; Bertone, Armando] Univ Montreal CETEDUM, Ctr Excellence Troubles Envahissants Dev, Montreal, PQ, Canada. RP Bertone, A (reprint author), Univ Montreal, Perceptual Neurosci Lab Autism & Dev Condit, Hop Riviere des Prairies, Montreal, PQ, Canada. EM armando.bertone@umontreal.ca FU Autism Speaks [1633]; Canadian Institute for Health Research (CIHR) FX Grant sponsor: Autism Speaks; Grant number: 1633.This study was supported by an Autism Speaks mentor-based (L.M.) fellowship to LK, and a Canadian Institute for Health Research (CIHR) operating grant to LM. We thank all the participants for their involvement in this project, and Michelle Dawson for editing the manuscript. CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Angelucci A, 2006, PROG BRAIN RES, V154, P93, DOI 10.1016/S0079-6123(06)54005-1 Ashwin E, 2009, BIOL PSYCHIAT, V65, P17, DOI 10.1016/j.biopsych.2008.06.012 Bach M., 2009, BIOL PSYCHIAT, V66, pe23 Bach Michael, 2009, Biol Psychiatry, V66, pe19, DOI 10.1016/j.biopsych.2009.02.035 Baldassi S, 2009, VISION RES, V49, P2151, DOI 10.1016/j.visres.2009.06.007 Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001 Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561 Casanova MF, 2002, NEUROLOGY, V58, P428 Casanova MF, 2006, ACTA NEUROPATHOL, V112, P287, DOI 10.1007/s00401-006-0085-5 COHEN IL, 1994, BIOL PSYCHIAT, V36, P5, DOI 10.1016/0006-3223(94)90057-4 Crewther David P, 2009, Biol Psychiatry, V66, pe21, DOI 10.1016/j.biopsych.2009.02.036 Crewther D.P., 2009, BIOL PSYCHIAT, V66, pe23 Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018 Danilova M. V., 2006, J VISION, V7, p[25, 1], DOI 10.1167/7.2.25 de Jonge MV, 2007, NEUROPSYCHOLOGY, V21, P65, DOI 10.1037/0894-4105.21.1.65 FLOM MERTON C., 1963, SCIENCE, V142, P979, DOI 10.1126/science.142.3594.979 FLOM MC, 1963, J OPT SOC AM, V53, P1026, DOI 10.1364/JOSA.53.001026 Franklin A, 2010, DEVELOPMENTAL SCI, V13, P188, DOI 10.1111/j.1467-7687.2009.00869.x Gilbert CD, 1998, PHYSIOL REV, V78, P467 Gustafsson L, 1997, J AUTISM DEV DISORD, V27, P219, DOI 10.1023/A:1025804226995 Gustafsson L, 1997, BIOL PSYCHIAT, V42, P1138, DOI 10.1016/S0006-3223(97)00141-8 Gustafsson L, 2004, NEUROSCIENTIST, V10, P189, DOI 10.1177/1073858404263493 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Harvey LO, 1997, SPATIAL VISION, V11, P121, DOI 10.1163/156856897X00159 Hess RF, 2000, VISION RES, V40, P365, DOI 10.1016/S0042-6989(99)00193-5 Intriligator J, 2001, COGNITIVE PSYCHOL, V43, P171, DOI 10.1006/cogp.2001.0755 Joseph RM, 2009, DEVELOPMENTAL SCI, V12, P1083, DOI 10.1111/j.1467-7687.2009.00855.x KOTHE AC, 1990, OPTOMETRY VISION SCI, V67, P283, DOI 10.1097/00006324-199004000-00009 Landolt E., 1905, AUGENHEILKUNDE, V13, P519 LANDOLT E, 1930, UNTERSUCHUNGSMETHODE, V1 Leat SJ, 1999, OPTOMETRY VISION SCI, V76, P198, DOI 10.1097/00006324-199904000-00023 Levi DM, 2008, VISION RES, V48, P635, DOI 10.1016/j.visres.2007.12.009 Levi DM, 2008, J VISION, V8, DOI 10.1167/8.4.1 LEVI DM, 1985, VISION RES, V25, P963, DOI 10.1016/0042-6989(85)90207-X LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 McClelland JL, 2000, J AUTISM DEV DISORD, V30, P497, DOI 10.1023/A:1005576229109 Milne E, 2009, J AUTISM DEV DISORD, V39, P965, DOI 10.1007/s10803-009-0705-8 Mottron L, 2003, J CHILD PSYCHOL PSYC, V44, P904, DOI 10.1111/1469-7610.00174 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Remington A, 2009, PSYCHOL SCI, V20, P1388, DOI 10.1111/j.1467-9280.2009.02454.x Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005 Simunovic MP, 2004, VISION RES, V44, P963, DOI 10.1016/j.visres.2003.11.019 Tommerdahl M, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-19 Vandenbroucke MWG, 2008, BRAIN, V131, P1013, DOI 10.1093/brain/awm321 Vattikuti S, 2010, BIOL PSYCHIAT, V67, P672, DOI 10.1016/j.biopsych.2009.09.008 Wang LX, 2007, COGN NEUROPSYCHOL, V24, P550, DOI 10.1080/13546800701417096 NR 49 TC 22 Z9 22 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2010 VL 3 IS 6 BP 333 EP 341 DI 10.1002/aur.164 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 707QJ UT WOS:000286300800005 PM 20928845 ER PT J AU Cochrane, LE Tansey, KE Gill, M Gallagher, L Anney, RJL AF Cochrane, Lynne E. Tansey, Katherine E. Gill, Michael Gallagher, Louise Anney, Richard J. L. TI Lack of Association Between Markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and Autism in an Irish Sample SO AUTISM RESEARCH LA English DT Article DE genetics; allelic association < statistical genetics ID PERVASIVE DEVELOPMENTAL DISORDERS; LONG-TERM POTENTIATION; NEURONAL MIGRATION; ALPHA-3-BETA-1 INTEGRIN; NEURITE OUTGROWTH; ALPHA-6 INTEGRINS; GENOMEWIDE SCREEN; LINKAGE ANALYSES; CEREBRAL-CORTEX; EXPRESSION AB Autism is a neurodeveloprnental disorder characterized by impairments in three core areas-language, social interaction and restricted/repetitive behaviours. It is generally accepted that genetics plays a large role in the aetiology of autism, but the exact mechanism is still unknown. We recently published evidence of an association between autism and the ITGA4 gene [Conroy et al., 2008]. Two genomic regions have shown evidence of linkage to autism in multiple studies 2q31-q33 and 17q21-q22. Both of these regions harbour multiple integrin subunit genes. We tested markers in ITGA3, ITGA6, ITGAV and ITGB3 for association with autism in the Irish autism sample. No markers in ITGA3, ITGA6, ITGAV and ITGB3 were found to be associated with autism. Three 3-marker haplotypes in ITGAV, ITGA3 and ITGA6 were found to be nominally associated (0.013.0.CO;2-V ALTHAM PME, 1984, J ROY STAT SOC B MET, V46, P118 Assaf Y, 2008, MAGN RESON MED, V59, P1347, DOI 10.1002/mrm.21577 Barazany D, 2009, BRAIN, V132, P1210, DOI 10.1093/brain/awp042 Basser PJ, 1996, J MAGN RESON SER B, V111, P209, DOI 10.1006/jmrb.1996.0086 Basser PJ, 1997, ANN NY ACAD SCI, V820, P123, DOI 10.1111/j.1749-6632.1997.tb46192.x BASSER PJ, 1994, BIOPHYS J, V66, P259 BEAULIEU C, 1994, MAGNET RESON MED, V32, P579, DOI 10.1002/mrm.1910320506 Bigler ED, 2003, AM J NEURORADIOL, V24, P2066 Bigler ED, 2007, DEV NEUROPSYCHOL, V31, P217 Casanova MF, 2009, J AUTISM DEV DISORD, V39, P751, DOI 10.1007/s10803-008-0681-4 Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2 Conturo TE, 1996, MAGNET RESON MED, V35, P399, DOI 10.1002/mrm.1910350319 CORTES C, 1995, MACH LEARN, V20, P273, DOI 10.1023/A:1022627411411 Criscione JC, 2000, J MECH PHYS SOLIDS, V48, P2445, DOI 10.1016/S0022-5096(00)00023-5 Ecker C, 2010, NEUROIMAGE, V49, P44, DOI 10.1016/j.neuroimage.2009.08.024 Ennis DB, 2006, MAGNET RESON MED, V55, P136, DOI 10.1002/mrm.20741 Fan XF, 2009, J AUTISM DEV DISORD, V39, P1499, DOI 10.1007/s10803-009-0767-7 Flagg EJ, 2005, NEUROSCI LETT, V386, P82, DOI 10.1016/j.neulet.2005.05.037 FLEISS JL, 1973, EDUC PSYCHOL MEAS, V33, P613, DOI 10.1177/001316447303300309 Fletcher PT, 2010, NEUROIMAGE, V51, P1117, DOI 10.1016/j.neuroimage.2010.01.083 GALABURDA AM, 1987, NEUROPSYCHOLOGIA, V25, P853, DOI 10.1016/0028-3932(87)90091-1 Jiao Y, 2010, NEUROIMAGE, V50, P589, DOI 10.1016/j.neuroimage.2009.12.047 KENNEDY DN, 1998, CEREB CORTEX, V8, P371 Kleinhans NM, 2008, BRAIN RES, V1221, P115, DOI 10.1016/j.brainres.2008.04.080 Koutsouleris N, 2009, ARCH GEN PSYCHIAT, V66, P700, DOI 10.1001/archgenpsychiatry.2009.62 Lainhart J, 2010, AUTISM SPECTRUM DISO Lange N, 1997, PSYCHIAT RES-NEUROIM, V74, P1, DOI 10.1016/S0925-4927(96)03054-5 LANGE N, 2005, ENCY BIOSTATISTICS Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042 Lee JE, 2009, NEUROIMAGE, V44, P870, DOI 10.1016/j.neuroimage.2008.09.041 Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Marenco S, 2007, P NATL ACAD SCI USA, V104, P15117, DOI 10.1073/pnas.0704311104 Neeley ES, 2007, BRAIN DEV-JPN, V29, P389, DOI 10.1016/j.braindev.2006.11.006 OLDFIELD RC, 1971, NEUROPSYCHOLOGIA, V9, P97, DOI 10.1016/0028-3932(71)90067-4 Pierpaoli C, 1996, MAGNET RESON MED, V36, P893, DOI 10.1002/mrm.1910360612 Ripley B., 1996, PATTERN RECOGNITION Roberts TPL, 2010, AUTISM RES, V3, P8, DOI 10.1002/aur.111 Semel E, 1995, CLIN EVALUATION LANG, V3rd Singh Vikas, 2008, Med Image Comput Comput Assist Interv, V11, P999 Song SK, 2002, NEUROIMAGE, V17, P1429, DOI 10.1006/nimg.2002.1267 Sparrow S, 1984, VINELAND ADAPTIVE BE van Belle G., 2004, BIOSTATISTICS METHOD Wilson TW, 2007, BIOL PSYCHIAT, V62, P192, DOI 10.1016/j.biopsych.2007.07.002 XU D, 2009, ANN INT C IEEE ENG M, V1, P2518 NR 50 TC 51 Z9 54 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2010 VL 3 IS 6 BP 350 EP 358 DI 10.1002/aur.162 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 707QJ UT WOS:000286300800008 PM 21182212 ER PT J AU Cook, EH AF Cook, Edwin H., Jr. TI Multiparameter Classification Approach to Structural Neuroimaging Data; Heterogeneity of 16p11.2 Microdeletion Clinical Presentation SO AUTISM RESEARCH LA English DT Review C1 Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA. RP Cook, EH (reprint author), Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA. EM ecook@psych.uic.edu CR COOK EH, 2001, AUTISM RES, V1, P308 Ecker C, 2010, J NEUROSCI, V30, P10612, DOI 10.1523/JNEUROSCI.5413-09.2010 HANSON E, 2010, J DEV BEHAV PEDIAT NR 3 TC 0 Z9 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2010 VL 3 IS 5 BP 286 EP 287 DI 10.1002/aur.166 PG 2 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 677FS UT WOS:000283975100009 ER PT J AU Bloemen, OJN Deeley, Q Sundram, F Daly, EM Barker, GJ Jones, DK van Amelsvoort, TAMJ Schmitz, N Robertson, D Murphy, KC Murphy, DGM AF Bloemen, Oswald J. N. Deeley, Quinton Sundram, Fred Daly, Eileen M. Barker, Gareth J. Jones, Derek K. van Amelsvoort, Therese A. M. J. Schmitz, Nicole Robertson, Dene Murphy, Kieran C. Murphy, Declan G. M. TI White Matter Integrity in Asperger Syndrome: A Preliminary Diffusion Tensor Magnetic Resonance Imaging Study in Adults SO AUTISM RESEARCH LA English DT Article DE autism; Asperger syndrome; white matter; DTI; connectivity ID AUTISM SPECTRUM DISORDERS; VOXEL-BASED MORPHOMETRY; POSITRON-EMISSION-TOMOGRAPHY; HIGH-FUNCTIONING AUTISM; CORPUS-CALLOSUM; HUMAN BRAIN; DISCONNECTION SYNDROMES; SENTENCE COMPREHENSION; CORTICAL ACTIVATION; WORKING-MEMORY AB Background: Autistic Spectrum Disorder (ASD), including Asperger syndrome and autism, is a highly genetic neurodevelopmental disorder. There is a consensus that ASD has a biological basis, and it has been proposed that it is a "connectivity" disorder. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) allows measurement of the microstructural integrity of white matter (a proxy measure of "connectivity"). However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome. Methods: We measured the fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) of white matter, using DT-MRI, in 13 adults with Asperger syndrome and 13 controls. The groups did not differ significantly in overall intelligence and age. FA, MD and RD were assessed using whole brain voxel-based techniques. Results: Adults with Asperger syndrome had a significantly lower FA than controls in 13 clusters. These were largely bilateral and included white matter in the internal capsule, frontal, temporal, parietal and occipital lobes, cingulum and corpus callosum. Conclusions: Adults with Asperger syndrome have widespread significant differences from controls in white matter microstructural integrity. C1 [Bloemen, Oswald J. N.; van Amelsvoort, Therese A. M. J.; Schmitz, Nicole] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands. [Bloemen, Oswald J. N.; Deeley, Quinton; Sundram, Fred; Daly, Eileen M.; Robertson, Dene; Murphy, Declan G. M.] Kings Coll London, Sect Brain Maturat, Div Psychol Med, Inst Psychiat, London WC2R 2LS, England. [Sundram, Fred; Murphy, Kieran C.] Royal Coll Surgeons Ireland, Dept Psychiat, Dublin 2, Ireland. [Barker, Gareth J.] Kings Coll London, Inst Psychiat, Dept Clin Neurosci, Ctr Neuroimaging Sci, London WC2R 2LS, England. [Jones, Derek K.] Cardiff Univ, Brain Res Imaging Ctr, Cardiff, S Glam, Wales. RP Bloemen, OJN (reprint author), Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands. EM O.J.N.Bloemen@amc.nl RI Schmitz, Nicole /F-9471-2011; daly, eileen/B-6716-2011; Murphy, Kieran/D-3577-2012; Jones, Derek/D-1460-2009; Barker, Gareth/C-9616-2009 OI Schmitz, Nicole /0000-0003-4178-4756; Barker, Gareth/0000-0002-5214-7421 FU MRC UK A.I.M.S. network; Maudsley NHS Trust; South London FX This study was supported by the MRC UK A.I.M.S. network, and the South London and Maudsley NHS Trust. The funding body had no further role in study design; in the collection, analysis and interpretation of the data; in the writing of the report; or in the decision to submit the paper for publication. CR Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032 Allison T, 2000, TRENDS COGN SCI, V4, P267, DOI 10.1016/S1364-6613(00)01501-1 [Anonymous], 1992, INT STAT CLASS DIS R BAILEY A, 1995, PSYCHOL MED, V25, P63 Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022 Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x Basser PJ, 1995, NMR BIOMED, V8, P333, DOI 10.1002/nbm.1940080707 BASSER PJ, 1994, BIOPHYS J, V66, P259 Beaulieu C, 2002, NMR BIOMED, V15, P435, DOI 10.1002/nbm.782 BELMONTE KM, 2000, AUTISM, V4, P269 Belmonte MK, 2003, COGNITIVE BRAIN RES, V17, P651, DOI 10.1016/S0926-6410(03)00189-7 BEN BD, 2007, NEUROIMAGE, V37, P40 Boddaert N, 2004, NEUROIMAGE, V23, P364, DOI 10.1016/j.neuroimage.2004.06.016 Bradshaw JL, 2000, BRAIN LANG, V73, P297, DOI 10.1006/brln.2000.2308 Brett M, 2002, NAT REV NEUROSCI, V3, P243, DOI 10.1038/nrn756 Bullmore ET, 1999, IEEE T MED IMAGING, V18, P32, DOI 10.1109/42.750253 CAREW JD, 2007, P INT SOC MAGNETIC R, V15, P1536 Carper RA, 2000, BRAIN, V123, P836, DOI 10.1093/brain/123.4.836 Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099 Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189 Catani M, 2005, BRAIN, V128, P2224, DOI 10.1093/brain/awh622 Catani M, 2008, NEUROIMAGE, V41, P1184, DOI 10.1016/j.neuroimage.2008.03.041 Catani M, 2003, BRAIN, V126, P2093, DOI 10.1093/brain/awg203 Catani M, 2002, NEUROIMAGE, V17, P77, DOI 10.1006/nimg.2002.1136 Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c Cheung C, 2009, J CHILD PSYCHOL PSYC, V50, P1102, DOI 10.1111/j.1469-7610.2009.02086.x Chung MK, 2004, NEUROIMAGE, V23, P242, DOI 10.1016/j.neuroimage.2004.04.037 Conturo TE, 2008, J INT NEUROPSYCH SOC, V14, P933, DOI 10.1017/S1355617708081381 Courchesne E, 2001, NEUROLOGY, V57, P245 COURCHESNE E, 1993, AM J ROENTGENOL, V160, P387 Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001 Courchesne E, 2005, DEV PSYCHOPATHOL, V17, P577, DOI 10.1017/S0954579405050285 Deeley Q, 2007, BIOL PSYCHIAT, V62, P207, DOI 10.1016/j.biopsych.2006.09.037 EGAAS B, 1995, ARCH NEUROL-CHICAGO, V52, P794 Frith C, 2004, LANCET NEUROL, V3, P577, DOI 10.1016/S1474-4422(04)00875-0 Frith CD, 1999, SCIENCE, V286, P1692, DOI 10.1126/science.286.5445.1692 Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9 Geschwind DH, 2007, CURR OPIN NEUROBIOL, V17, P103, DOI 10.1016/j.conb.2007.01.009 HAMMOCK EAD, 2006, J COGNITIVE NEUROSCI, V16, P1412 Happe F, 1996, NEUROREPORT, V8, P197, DOI 10.1097/00001756-199612200-00040 Hardan AY, 2000, NEUROLOGY, V55, P1033 Haznedar MM, 2000, AM J PSYCHIAT, V157, P1994, DOI 10.1176/appi.ajp.157.12.1994 Heilman KM, 1998, J CLIN NEUROPHYSIOL, V15, P409, DOI 10.1097/00004691-199809000-00005 Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032 Iacoboni M, 2005, CURR OPIN NEUROBIOL, V15, P632, DOI 10.1016/j.conb.2005.10.010 Jones DK, 2002, HUM BRAIN MAPP, V15, P216, DOI 10.1002/hbm.10018 Jones DK, 2005, NEUROIMAGE, V26, P546, DOI 10.1016/j.neuroimage.2005.02.013 Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Ke XY, 2009, BRAIN RES, V1265, P171, DOI 10.1016/j.brainres.2009.02.013 Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99 Knudsen EI, 2004, J COGNITIVE NEUROSCI, V16, P1412, DOI 10.1162/0898929042304796 Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028 Lee JE, 2007, NEUROSCI LETT, V424, P127, DOI 10.1016/j.neulet.2007.07.042 Levitt JG, 2003, CEREB CORTEX, V13, P728, DOI 10.1093/cercor/13.7.728 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Luna B, 2002, NEUROLOGY, V59, P834 Mandonnet E, 2007, BRAIN, V130, P623, DOI 10.1093/brain/awl361 Manes F, 1999, J NEUROPSYCH CLIN N, V11, P470 Mason RA, 2008, NEUROPSYCHOLOGIA, V46, P269, DOI 10.1016/j.neuropsychologia.2007.07.018 McAlonan GM, 2002, BRAIN, V125, P1594, DOI 10.1093/brain/awf150 Meresse IG, 2005, ANN NEUROL, V58, P466, DOI 10.1002/ana.20597 Meyer M, 2005, NEUROREPORT, V16, P1985, DOI 10.1097/00001756-200512190-00003 Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303 Mori S., 2005, MRI ATLAS HUMAN WHIT Muller RA, 1998, NEUROSCI LETT, V245, P1, DOI 10.1016/S0304-3940(98)00151-7 Muller RA, 2001, BIOL PSYCHIAT, V49, P665, DOI 10.1016/S0006-3223(00)01004-0 Muller RA, 2007, MENT RETARD DEV D R, V13, P85, DOI 10.1002/mrdd.20141 Mundy P, 2003, J CHILD PSYCHOL PSYC, V44, P793, DOI 10.1111/1469-7610.00165 Northoff G, 2004, TRENDS COGN SCI, V8, P102, DOI 10.1016/j.tics.2004.01.004 Pierpaoli C, 1996, MAGNET RESON MED, V36, P893, DOI 10.1002/mrm.1910360612 Piven J, 1996, J AM ACAD CHILD PSY, V35, P530, DOI 10.1097/00004583-199604000-00020 Piven J, 1997, AM J PSYCHIAT, V154, P1051 Song SK, 2002, NEUROIMAGE, V17, P1429, DOI 10.1006/nimg.2002.1267 Song SK, 2005, NEUROIMAGE, V26, P132, DOI 10.1016/j.neuroimage.2005.01.028 Sundaram SK, 2008, CEREB CORTEX, V18, P2659, DOI 10.1093/cercor/bhn031 Talairach J., 1988, COPLANAR STEREOTAXIC Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099 Toal F, 2005, BRIT J PSYCHIAT, V187, P395, DOI 10.1192/bjp.187.5.395 Vidal CN, 2006, BIOL PSYCHIAT, V60, P218, DOI 10.1016/j.biopsych.2005.11.011 Vigneau M, 2006, NEUROIMAGE, V30, P1414, DOI 10.1016/j.neuroimage.2005.11.002 Vuilleumier P, 2004, NAT NEUROSCI, V7, P1271, DOI 10.1038/nn1341 Waiter GD, 2005, NEUROIMAGE, V24, P455, DOI 10.1016/j.neuroimage.2004.08.049 WESCHLER D, 1987, WESCHLER ADULT INTEL Wheeler-Kingshott CAM, 2009, MAGN RESON MED, V61, P1255, DOI 10.1002/mrm.21965 Williams DL, 2006, CHILD NEUROPSYCHOL, V12, P279, DOI 10.1080/09297040600681190 NR 89 TC 32 Z9 35 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2010 VL 3 IS 5 BP 203 EP 213 DI 10.1002/aur.146 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 677FS UT WOS:000283975100001 PM 20625995 ER PT J AU Bhatara, A Quintin, EM Levy, B Bellugi, U Fombonne, E Levitin, DJ AF Bhatara, Anjali Quintin, Eve-Marie Levy, Bianca Bellugi, Ursula Fombonne, Eric Levitin, Daniel J. TI Perception of Emotion in Musical Performance in Adolescents with Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; Asperger syndrome; Williams syndrome; music; emotion perception; auditory perception ID WILLIAMS-SYNDROME; ASPERGER-SYNDROME; FUNCTIONING INDIVIDUALS; UNDERSTANDING EMOTIONS; METHODOLOGICAL ISSUES; AUDITORY-STIMULI; YOUNG-CHILDREN; SPEECH PROSODY; RECOGNITION; LANGUAGE AB Individuals with autism spectrum disorders (ASD) are impaired in understanding the emotional undertones of speech, many of which are communicated through prosody. Musical performance also employs a form of prosody to communicate emotion, and the goal of this study was to examine the ability of adolescents with ASD to understand musical emotion. We designed an experiment in which each musical stimulus served as its own control while we varied the emotional expressivity by manipulating timing and amplitude variation. We asked children and adolescents with ASD and matched controls as well as individuals with Williams syndrome (WS) to rate how emotional these excerpts sounded. Results show that children and adolescents with ASD are impaired relative to matched controls and individuals with WS at judging the difference in emotionality among the expressivity levels. Implications for theories of emotion in autism are discussed in light of these findings. C1 [Bhatara, Anjali; Levy, Bianca; Levitin, Daniel J.] McGill Univ, Dept Psychol, Montreal, PQ H3A 1B1, Canada. [Quintin, Eve-Marie] Univ Quebec, Dept Psychol, Montreal, PQ H3C 3P8, Canada. [Bellugi, Ursula] Salk Inst Biol Studies, Cognit Neurosci Lab, La Jolla, CA 92037 USA. [Fombonne, Eric] McGill Univ, Montreal Childrens Hosp, Dept Psychiat, Montreal, PQ H3A 1B1, Canada. RP Bhatara, A (reprint author), McGill Univ, Dept Psychol, 1205 Ave Penfield, Montreal, PQ H3A 1B1, Canada. EM anjali.bhatara@mail.mcgill.ca FU National Alliance for Autism Research (NAAR) [066/DL/01-201-005-001-00-00]; National Science and Engineering Research Council of Canada (NSERC) [228175-04]; National Institute of Child Health and Human Development (NICHD) [HD 33113]; National Institute of Neurological Disorders and Stroke (NINDS) [NS 22343]; SSHRC; CFI; NIH FX Grant sponsor: National Alliance for Autism Research (NAAR; now Autism Speaks); Grant number: #066/DL/01-201-005-001-00-00; Grant sponsor: National Science and Engineering Research Council of Canada (NSERC); Grant number: #228175-04; Grant sponsor: National Institute of Child Health and Human Development (NICHD); Grant number: HD 33113; Grant sponsor: National Institute of Neurological Disorders and Stroke (NINDS); Grant number: NS 22343; Grant sponsors: SSHRC; CFI; NIH. CR Adolphs R, 2001, J COGNITIVE NEUROSCI, V13, P232, DOI 10.1162/089892901564289 Alcantara JI, 2004, J CHILD PSYCHOL PSYC, V45, P1107, DOI 10.1111/j.1469-7610.2004.t01-1-00303.x Altgassen M, 2005, BRIT J DEV PSYCHOL, V23, P543, DOI 10.1348/026151005X26840 BARONCOHEN S, 1993, COGNITION EMOTION, V7, P507, DOI 10.1080/02699939308409202 BERNSTEIN L, 1976, UNANSWERED QUESTIONS Bonnel A, 2003, J COGNITIVE NEUROSCI, V15, P226, DOI 10.1162/089892903321208169 Boucher J, 2000, J CHILD PSYCHOL PSYC, V41, P847, DOI 10.1017/S0021963099006149 Bruneau N, 1999, CLIN NEUROPHYSIOL, V110, P1927, DOI 10.1016/S1388-2457(99)00149-2 Bruneau N, 2003, INT J PSYCHOPHYSIOL, V51, P17, DOI 10.1016/S0167-8760(03)00149-1 Castelli F, 2005, AUTISM, V9, P428, DOI 10.1177/1362361305056082 Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 Cuddy LL, 2005, ANN NY ACAD SCI, V1060, P311, DOI 10.1196/annals.1360.026 Dalla Bella S, 2001, COGNITION, V80, pB1, DOI 10.1016/S0010-0277(00)00136-0 Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611 Don AJ, 1999, CHILD NEUROPSYCHOL, V5, P154, DOI 10.1076/chin.5.3.154.7337 Downs A, 2004, J AUTISM DEV DISORD, V34, P625, DOI 10.1007/s10803-004-5284-0 Gabrielsson A., 1999, PSYCHOL MUSIC, P501, DOI 10.1016/B978-012213564-4/50015-9 Gervais H, 2004, NAT NEUROSCI, V7, P801, DOI 10.1038/nn1291 Ghaziuddin M, 2008, J AUTISM DEV DISORD, V38, P138, DOI 10.1007/s10803-007-0371-7 Golan O, 2007, J AUTISM DEV DISORD, V37, P1096, DOI 10.1007/s10803-006-0252-5 Gregory AH, 1996, MOTIV EMOTION, V20, P341, DOI 10.1007/BF02856522 Groen WB, 2009, J AUTISM DEV DISORD, V39, P742, DOI 10.1007/s10803-008-0682-3 Gross TF, 2004, J ABNORM CHILD PSYCH, V32, P469, DOI 10.1023/B:JACP.0000037777.17698.01 Grossman JB, 2000, J CHILD PSYCHOL PSYC, V41, P369, DOI 10.1017/S0021963099005466 Heaton P, 2005, J AUTISM DEV DISORD, V35, P787, DOI 10.1007/s10803-005-0024-7 Heaton P, 1999, PSYCHOL MED, V29, P1405, DOI 10.1017/S0033291799001221 Heaton P, 2003, J CHILD PSYCHOL PSYC, V44, P543, DOI 10.1111/1469-7610.00143 Heaton P, 1998, MUSIC PERCEPT, V15, P291 Heaton P, 2008, BRIT J DEV PSYCHOL, V26, P171, DOI 10.1348/026151007X206776 Hevner K, 1935, AM J PSYCHOL, V47, P103, DOI 10.2307/1416710 HOBSON RP, 1988, PSYCHOL MED, V18, P911 HOBSON RP, 1991, J CHILD PSYCHOL PSYC, V32, P1135, DOI 10.1111/j.1469-7610.1991.tb00354.x Hopyan T, 2001, CHILD NEUROPSYCHOL, V7, P42, DOI 10.1076/chin.7.1.42.3147 Jarrold C, 2004, J AUTISM DEV DISORD, V34, P81, DOI 10.1023/B:JADD.0000018078.82542.ab Jones CRG, 2009, NEUROPSYCHOLOGIA, V47, P2850, DOI 10.1016/j.neuropsychologia.2009.06.015 Juslin PN, 2003, PSYCHOL BULL, V129, P770, DOI 10.1037/0033-2909.129.5.770 Juslin PN, 2004, J NEW MUSIC RES, V33, P217, DOI 10.1080/0929821042000317813 Kamenetsky S. B, 1997, PSYCHOL MUSIC, V25, P149, DOI [10.1177/0305735697252005, DOI 10.1177/0305735697252005] Kanner L, 1943, NERV CHILD, V2, P217 KASTNER MP, 1990, MUSIC PERCEPT, V8, P189 KENNEDY M, 1999, OXFORD DICT MUSIC KILN A, 2005, HDB AUTISM PERVASIVE, V1 Kivy Peter, 1980, CORDED SHELL REFLECT Koelsch S, 2005, TRENDS COGN SCI, V9, P578, DOI 10.1016/j.tics.2005.10.001 Korenberg JR, 2000, J COGNITIVE NEUROSCI, V12, P89, DOI 10.1162/089892900562002 Korpilahti P, 2007, J AUTISM DEV DISORD, V37, P1539, DOI 10.1007/s10803-006-0271-2 Levitin DJ, 2005, ANN NY ACAD SCI, V1060, P325, DOI 10.1196/annals.1360.027 Levitin DJ, 2003, NEUROIMAGE, V20, P2142, DOI 10.1016/j.neuroimage.2003.08.016 Levitin DJ, 1998, MUSIC PERCEPT, V15, P357 Levitin DJ, 2005, MUSIC PERCEPT, V22, P563, DOI 10.1525/mp.2005.22.3.563 Levitin DJ, 2004, CHILD NEUROPSYCHOL, V10, P223, DOI 10.1080/09297040490909288 LINCOLN AJ, 1995, J AUTISM DEV DISORD, V25, P521, DOI 10.1007/BF02178298 Loveland K., 2005, EMOTIONAL DEV RECENT, P365 Loveland KA, 1997, DEV PSYCHOPATHOL, V9, P579 Magne C, 2003, ANN NY ACAD SCI, V999, P461, DOI 10.1196/annals.1284.056 Mazefsky CA, 2007, J AUTISM DEV DISORD, V37, P1086, DOI 10.1007/s10803-006-0251-6 Mervis CB, 2000, BRAIN COGNITION, V44, P604, DOI 10.1006/brcg.2000.1232 Mottron L, 2000, J CHILD PSYCHOL PSYC, V41, P1057, DOI 10.1017/S0021963099006253 NILSONNE A, 1985, MUSIC PERCEPT, V2, P507 OZONOFF S, 1990, J CHILD PSYCHOL PSYC, V31, P343, DOI 10.1111/j.1469-7610.1990.tb01574.x Palmer C, 1997, ANNU REV PSYCHOL, V48, P115, DOI 10.1146/annurev.psych.48.1.115 Parncutt R., 2002, SCI PSYCHOL MUSIC PE, P285, DOI DOI 10.1093/ACPR0F:0S0/9780195138108.001.0001 Patel AD, 2003, NAT NEUROSCI, V6, P674, DOI 10.1038/nn1082 Patel AD, 1998, BRAIN LANG, V61, P123, DOI 10.1006/brln.1997.1862 Paul R, 2005, J AUTISM DEV DISORD, V35, P205, DOI 10.1007/s10803-005-1999-9 PEPPE S, 2007, J SPEECH LANG HEAR R, V50, P1097 Pierce K, 1997, J AUTISM DEV DISORD, V27, P265, DOI 10.1023/A:1025898314332 REPP BH, 1995, MUSIC PERCEPT, V13, P39 Rose FE, 2007, J AUTISM DEV DISORD, V37, P513, DOI 10.1007/s10803-006-0200-4 RUSSELL JA, 1980, J PERS SOC PSYCHOL, V39, P1161, DOI 10.1037/h0077714 Rutter M., 2003, SCQ SOCIAL COMMUNICA Samson F, 2006, J AUTISM DEV DISORD, V36, P65, DOI 10.1007/s10803-005-0043-4 Saulnier CA, 2007, J AUTISM DEV DISORD, V37, P788, DOI 10.1007/s10803-006-0288-6 Skwerer DP, 2007, LANG COGNITIVE PROC, V22, P247, DOI 10.1080/01690960600632671 SMITH B, 1995, SOC MUS PERC COGN C TANTAM D, 1989, J CHILD PSYCHOL PSYC, V30, P623, DOI 10.1111/j.1469-7610.1989.tb00274.x TAYLOR C, 1965, PHYS MUSICAL SOUNDS THAUT MH, 1987, J AUTISM DEV DISORD, V17, P425, DOI 10.1007/BF01487071 Thompson WF, 2004, EMOTION, V4, P46, DOI 10.1037/1528-3542.4.1.46 Wang AT, 2007, ARCH GEN PSYCHIAT, V64, P698, DOI 10.1001/archpsyc.64.6.698 WEEKS SJ, 1987, J CHILD PSYCHOL PSYC, V28, P137, DOI 10.1111/j.1469-7610.1987.tb00658.x *WILL SYNDR, 2010, WILL SYNDR CAMPS Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8 NR 83 TC 12 Z9 12 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2010 VL 3 IS 5 BP 214 EP 225 DI 10.1002/aur.147 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 677FS UT WOS:000283975100002 PM 20717952 ER PT J AU Vladusich, T Olu-Lafe, O Kim, DS Tager-Flusberg, H Grossberg, S AF Vladusich, Tony Olu-Lafe, Olufemi Kim, Dae-Shik Tager-Flusberg, Helen Grossberg, Stephen TI Prototypical Category Learning in High-Functioning Autism SO AUTISM RESEARCH LA English DT Article DE autism; category; learning; prototype; exemplar; memory; attention; vigilance; adaptive resonance theory ID 3D SURFACE PERCEPTION; HIERARCHICAL PATTERNS; VISUAL-SEARCH; CHILDRENS ANALYSIS; MEMORY; DISCRIMINATION; CATEGORIZATION; MICROGENESIS; ORGANIZATION; MECHANISMS AB An ongoing debate in developmental cognitive neuroscience is whether individuals with autism are able to learn prototypical category representations from multiple exemplars. Prototype learning and memory were examined in a group of high-functioning autistic boys and young men, using a classic paradigm in which participants learned to classify novel dot patterns into one of two categories. Participants were trained on distorted versions of category prototypes until they reached a criterion level of performance. During transfer testing, participants were shown the training items together with three novel stimulus sets manifesting variable levels of physical distortion (low, medium, or high distortion) relative to the unseen prototypes. Two experiments were conducted, differing only in the manner in which the physical distortions were defined. In the first experiment, a subset of autistic individuals learned categories more slowly than controls, accompanied by an overall diminution in transfer-testing performance. The autism group did, however, manifest a typical pattern of performance across the testing conditions, relative to controls. In the second experiment, group means did not differ statistically in either the training or testing phases. Taken together, these data indicate that high-functioning autistic individuals do not manifest gross deficits in prototypical category learning. A theoretical discussion is given in terms of how perceptual grouping may interact with category learning. C1 [Vladusich, Tony; Grossberg, Stephen] Boston Univ, Dept Cognit & Neural Syst, Boston, MA 02215 USA. [Olu-Lafe, Olufemi; Tager-Flusberg, Helen] Boston Univ, Dept Psychol, Boston, MA 02215 USA. [Tager-Flusberg, Helen] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02215 USA. [Kim, Dae-Shik] Boston Univ, Biomed Imaging Ctr, Boston, MA 02215 USA. [Vladusich, Tony; Grossberg, Stephen] Boston Univ, Ctr Adapt Syst, Boston, MA 02215 USA. [Vladusich, Tony; Olu-Lafe, Olufemi; Tager-Flusberg, Helen; Grossberg, Stephen] Boston Univ, Ctr Excellence Learning Educ Sci & Technol, Boston, MA 02215 USA. RP Grossberg, S (reprint author), Boston Univ, Dept Cognit & Neural Syst, 677 Beacon St, Boston, MA 02215 USA. EM steve@bu.edu RI Kim, Dae-Shik/C-2071-2011 FU CELEST NSF [SBE-0354378]; CELEST; NSF Science of Learning center [NSF SBE-0354378] FX Grant sponsor: CELEST NSF; Grant number: SBE-0354378.Supported in part by CELEST, an NSF Science of Learning center (NSF SBE-0354378). We thank Jacqueline Liederman and Robert Joseph for advice regarding experimental design. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT BACON WF, 1991, J EXP PSYCHOL HUMAN, V17, P77, DOI 10.1037//0096-1523.17.1.77 BANKS WP, 1976, PERCEPT PSYCHOPHYS, V19, P361, DOI 10.3758/BF03204244 Bott L, 2006, Q J EXP PSYCHOL, V59, P1237, DOI 10.1080/02724980543000196 BRAVO M, 1990, PERCEPTION, V19, P515, DOI 10.1068/p190515 Cao YQ, 2005, SPATIAL VISION, V18, P515, DOI 10.1163/156856805774406756 Caron MJ, 2006, BRAIN, V129, P1789, DOI 10.1093/brain/awl072 Dukette D, 1996, J EXP CHILD PSYCHOL, V63, P103, DOI 10.1006/jecp.1996.0044 Dukette D, 2001, DEVELOPMENTAL SCI, V4, P233, DOI 10.1111/1467-7687.00168 ENNS JT, 1990, SCIENCE, V247, P721, DOI 10.1126/science.2300824 Fang L, 2009, SPATIAL VISION, V22, P45, DOI 10.1163/156856809786618484 Frith U., 2003, AUTISM EXPLAINING EN Gastgeb HZ, 2006, CHILD DEV, V77, P1717, DOI 10.1111/j.1467-8624.2006.00969.x GROSSBERG S, 1994, PERCEPT PSYCHOPHYS, V55, P48, DOI 10.3758/BF03206880 Grossberg S, 2009, J VISION, V9, DOI 10.1167/9.4.6 Grossberg Stephen, 2003, Behav Cogn Neurosci Rev, V2, P47, DOI 10.1177/1534582303002001003 Grossberg S, 2006, PSYCHOL REV, V113, P483, DOI 10.1037/0033-295X.113.3.483 Grossberg S, 2005, VISION RES, V45, P1725, DOI 10.1016/j.visres.2005.01.006 HE ZJ, 1992, NATURE, V359, P231, DOI 10.1038/359231a0 HUMPHREYS GW, 1989, J EXP PSYCHOL GEN, V118, P258, DOI 10.1037//0096-3445.118.3.258 Kimchi R, 1998, J EXP PSYCHOL HUMAN, V24, P1105, DOI 10.1037/0096-1523.24.4.1105 Kimchi R, 2005, PSYCHOL SCI, V16, P282, DOI 10.1111/j.0956-7976.2005.01529.x Klinger LG, 2001, DEV PSYCHOPATHOL, V13, P111, DOI 10.1017/S0954579401001080 KNOWLTON BJ, 1993, SCIENCE, V262, P1747, DOI 10.1126/science.8259522 Lupyan G, 2007, PSYCHOL SCI, V18, P1077, DOI 10.1111/j.1467-9280.2007.02028.x Molesworth CJ, 2008, J AUTISM DEV DISORD, V38, P1721, DOI 10.1007/s10803-008-0557-7 Molesworth CJ, 2005, J CHILD PSYCHOL PSYC, V46, P661, DOI 10.1111/j.1469-7610.2004.00383.x Mottron L, 2003, J CHILD PSYCHOL PSYC, V44, P904, DOI 10.1111/1469-7610.00174 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Pellicano E, 2007, CURR BIOL, V17, P1508, DOI 10.1016/j.cub.2007.07.065 Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P765, DOI 10.1017/S0021963098002601 Plaisted K, 2006, J AUTISM DEV DISORD, V36, P107, DOI 10.1007/s10803-005-0047-0 POSNER MI, 1968, J EXP PSYCHOL, V77, P353, DOI 10.1037/h0025953 Reber PJ, 1998, P NATL ACAD SCI USA, V95, P747, DOI 10.1073/pnas.95.2.747 Scherf KS, 2008, AUTISM RES, V1, P114, DOI 10.1002/aur.17 Soulieres I, 2007, J AUTISM DEV DISORD, V37, P481, DOI 10.1007/s10803-006-0172-4 Squire LR, 1995, P NATL ACAD SCI USA, V92, P12470, DOI 10.1073/pnas.92.26.12470 TAGERFLUSBERG H, 1985, J EXP CHILD PSYCHOL, V40, P450, DOI 10.1016/0022-0965(85)90077-3 Zaki SR, 2004, MEM COGNITION, V32, P390, DOI 10.3758/BF03195833 Zaki SR, 2007, MEM COGNITION, V35, P2088, DOI 10.3758/BF03192940 NR 40 TC 11 Z9 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2010 VL 3 IS 5 BP 226 EP 236 DI 10.1002/aur.148 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 677FS UT WOS:000283975100003 PM 20717947 ER PT J AU Sacco, R Curatolo, P Manzi, B Militerni, R Bravaccio, C Frolli, A Lenti, C Saccani, M Elia, M Reichelt, KL Pascucci, T Puglisi-Allegra, S Persico, AM AF Sacco, Roberto Curatolo, Paolo Manzi, Barbara Militerni, Roberto Bravaccio, Carmela Frolli, Alessandro Lenti, Carlo Saccani, Monica Elia, Maurizio Reichelt, Karl-Ludvig Pascucci, Tiziana Puglisi-Allegra, Stefano Persico, Antonio M. TI Principal Pathogenetic Components and Biological Endophenotypes in Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autistic disorder; macrocephaly; neurodevelopment; pervasive developmental disorders; principal component analysis; serotonin ID HEAD CIRCUMFERENCE; OPIOID-PEPTIDES; DIETARY INTERVENTION; PERINATAL FACTORS; RISK-FACTORS; CHILDREN; BRAIN; SEROTONIN; DYSFUNCTION; VARIANTS AB Autism is a complex neurodevelopmental disorder, likely encompassing multiple pathogenetic components. The aim of this study is to begin identifying at least some of these components and to assess their association with biological endophenotypes. To address this issue, we recruited 245 Italian patients with idiopathic autism spectrum disorders and their first-degree relatives. Using a stepwise approach, patient and family history variables were analyzed using principal component analysis ("exploratory phase"), followed by intra- and inter-component cross-correlation analyses ("follow-up phase"), and by testing for association between each component and biological endophenotypes, namely head circumference, serotonin blood levels, and global urinary peptide excretion rates ("biological correlation phase"). Four independent components were identified, namely "circadian 87: sensory dysfunction," "immune dysfunction," "neurodevelopmental delay," and "stereotypic behavior," together representing 74.5% of phenotypic variance in our sample. Marker variables in the latter three components are positively associated with macrocephaly, global peptiduria, and serotonin blood levels, respectively. These four components point toward at least four processes associated with autism, namely (I) a disruption of the circadian cycle associated with behavioral and sensory abnormalities, (II) dysreactive immune processes, surprisingly linked both to prenatal obstetric complications and to excessive postnatal body growth rates, (III) a generalized developmental delay, and (IV) an abnormal neural circuitry underlying stereotypies and early social behaviors. C1 [Sacco, Roberto; Persico, Antonio M.] Univ Campus Biomed, Lab Mol Psychiat & Neurogenet, I-00128 Rome, Italy. [Sacco, Roberto; Persico, Antonio M.] Fdn Santa Lucia, Rome, Italy. [Curatolo, Paolo; Manzi, Barbara] Univ Roma Tor Vergata, Dept Child Neuropsychiat, Rome, Italy. [Militerni, Roberto; Frolli, Alessandro] Univ Naples 2, Dept Neuropsychiat, Naples, Italy. [Bravaccio, Carmela] Univ Naples Federico 2, Dept Pediat, Naples, Italy. [Lenti, Carlo; Saccani, Monica] Univ Milan, Dept Child Neuropsychiat, Milan, Italy. [Elia, Maurizio] IRCCS Oasi Maria SS, Unit Neurol & Clin Neurophysiopathol, Troina, EN, Italy. [Reichelt, Karl-Ludvig] Univ Oslo, Rikshosp, Dept Pediat Res, N-0027 Oslo, Norway. [Pascucci, Tiziana; Puglisi-Allegra, Stefano] Univ Roma La Sapienza, Dept Psychol, Rome, Italy. [Pascucci, Tiziana; Puglisi-Allegra, Stefano] IRCCS Fdn Santa Lucia, Rome, Italy. RP Persico, AM (reprint author), Univ Campus Biomed, Lab Mol Psychiat & Neurogenet, Via Alvaro de Portillo 21, I-00128 Rome, Italy. EM a.persico@unicampus.it FU Italian Ministry for University, Scientific Research and Technology [PRIN n.2006058195]; Italian Ministry of Health [RFPS-2007-5-640174]; Autism Speaks Foundation; Autism Speaks Foundation (Princeton, NJ) FX Grant sponsor: Italian Ministry for University, Scientific Research and Technology; Grant number: PRIN n.2006058195; Grant sponsor: Italian Ministry of Health; Grant number: RFPS-2007-5-640174; Grant sponsor: Autism Speaks Foundation.The authors gratefully acknowledge all the families who participated in this study, Louis Tao (Department of Biostatistics, University of Beijing, China) for providing statistical advise and for reviewing the manuscript, Giacomo Rizzolatti (Department of Physiology, University of Parma, Italy) for helpful discussion, and Roberto Rigardetto, Marina Gandione, Simona Trillo, and Maria Paola Santangelo for contributing to patient recruitment and data collection. This work was supported by the Italian Ministry for University, Scientific Research and Technology (PRIN n.2006058195), the Italian Ministry of Health (RFPS-2007-5-640174), and the Autism Speaks Foundation (Princeton, NJ). CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 BUSHBY KMD, 1992, ARCH DIS CHILD, V67, P1286 Cass H, 2008, ARCH DIS CHILD, V93, P745, DOI 10.1136/adc.2006.114389 Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007 Courchesne E, 2007, NEURON, V56, P399, DOI 10.1016/j.neuron.2007.10.016 Dettmer K, 2007, ANAL BIOANAL CHEM, V388, P1643, DOI 10.1007/s00216-007-1301-4 DiCicco-Bloom E, 2006, J NEUROSCI, V26, P6897, DOI 10.1523/JNEUROSCI.1712-06.2006 Durkin MS, 2008, AM J EPIDEMIOL, V168, P1268, DOI 10.1093/aje/kwn250 Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3 Garbett K, 2008, NEUROBIOL DIS, V30, P303, DOI 10.1016/j.nbd.2008.01.012 Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618 GOTTESMAN, 2003, PSYCHIATRY, V160, P636 HAMILL PVV, 1979, AM J CLIN NUTR, V32, P607 Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8 Hu VW, 2009, AUTISM RES, V2, P78, DOI 10.1002/aur.73 Huh GS, 2000, SCIENCE, V290, P2155, DOI 10.1126/science.290.5499.2155 Hunter LC, 2003, DEV MED CHILD NEUROL, V45, P121, DOI 10.1017/S0012162203000227 Jyonouchi H, 2005, NEUROPSYCHOBIOLOGY, V51, P77, DOI 10.1159/000084164 Kolevzon A, 2007, ARCH PEDIAT ADOL MED, V161, P326, DOI 10.1001/archpedi.161.4.326 Krey JF, 2007, CURR OPIN NEUROBIOL, V17, P112, DOI 10.1016/j.conb.2007.01.010 Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465 Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123 LEBOYER M, 1994, AM J PSYCHIAT, V151, P1797 Lintas C, 2009, MOL PSYCHIATR, V14, P705, DOI 10.1038/mp.2008.21 Lintas C, 2009, J MED GENET, V46, P1, DOI 10.1136/jmg.2008.060871 Lord C, 2005, ADOS AUTISM DIAGNOST McBride P. Anne, 1998, Journal of the American Academy of Child and Adolescent Psychiatry, V37, P767, DOI 10.1097/00004583-199807000-00017 Meisel H, 2000, BRIT J NUTR, V84, pS27 Melke J, 2008, MOL PSYCHIATR, V13, P90, DOI 10.1038/sj.mp.4002016 Miller MT, 2005, INT J DEV NEUROSCI, V23, P201, DOI 10.1016/j.ijdevneu.2004.06.007 PALMIERI L, 2010, MOL PSYCHIATR, V1, P38 Persico AM, 2006, TRENDS NEUROSCI, V29, P349, DOI 10.1016/j.tins.2006.05.010 PERSICO AM, 2008, EXPT MODELS SEROTONI, P78 Persico AM, 2002, MOL PSYCHIATR, V7, P795, DOI 10.1038/sj.mp.4001069 Piven J, 1997, AM J PSYCHIAT, V154, P185 PIVEN J, 1991, J AUTISM DEV DISORD, V21, P51, DOI 10.1007/BF02206997 Reichelt WH, 1997, DEV BRAIN DYSFUNCT, V10, P44 Reichelt WH, 1998, J PEDIATR GASTR NUTR, V26, P305, DOI 10.1097/00005176-199803000-00012 Rizzolatti G, 2008, CURR OPIN NEUROBIOL, V18, P179, DOI 10.1016/j.conb.2008.08.001 ROLF LH, 1993, ACTA PSYCHIAT SCAND, V87, P312, DOI 10.1111/j.1600-0447.1993.tb03378.x Rutter M, 2005, ADI R AUTISM DIAGNOS Sacco R, 2007, BIOL PSYCHIAT, V62, P1038, DOI 10.1016/j.biopsych.2007.04.039 SAHLEY TL, 1987, J AUTISM DEV DISORD, V17, P201, DOI 10.1007/BF01495056 Saresella M, 2009, BIOL PSYCHIAT, V66, P978, DOI 10.1016/j.biopsych.2009.06.020 Sparrow S, 1984, VINELAND ADAPTIVE BE Stevens B, 2007, CELL, V131, P1164, DOI 10.1016/j.cell.2007.10.036 TABACHNICK BG, 1989, USING MULTIVARIATE S, P597 Tadevosyan-Leyfer O, 2003, J AM ACAD CHILD PSY, V42, P864, DOI 10.1097/01.CHI.0000046870.56865.90 Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6 Vargas DL, 2005, ANN NEUROL, V57, P67, DOI 10.1002/ana.20315 NR 51 TC 32 Z9 33 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2010 VL 3 IS 5 BP 237 EP 252 DI 10.1002/aur.151 PG 16 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 677FS UT WOS:000283975100004 PM 20878720 ER PT J AU Russo, N Foxe, JJ Brandwein, AB Altschuler, T Gomes, H Molholm, S AF Russo, Natalie Foxe, John J. Brandwein, Alice B. Altschuler, Ted Gomes, Hilary Molholm, Sophie TI Multisensory Processing in Children with Autism: High-Density Electrical Mapping of Auditory Somatosensory Integration SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; electrophysiology; multisensory integration; auditory processing; somatosensory processing; development ID HIGH-FUNCTIONING AUTISM; AUDIOVISUAL SPEECH INTEGRATION; EVENT-RELATED POTENTIALS; LOW-LEVEL; SELECTIVE ATTENTION; OBJECT RECOGNITION; SPECTRUM DISORDERS; VISUAL INTEGRATION; SENSORY MODALITIES; HUMANS AB Successful integration of signals from the various sensory systems is crucial for normal sensory perceptual functioning, allowing for the perception of coherent objects rather than a disconnected cluster of fragmented features. Several prominent theories of autism suggest that automatic integration is impaired in this population, but there have been few empirical tests of this thesis. A standard electrophysiological metric of multisensory integration (MSI) was used to test the integrity of auditory somatosensory integration in children with autism (N = 17, aged 6-16 years), compared to age- and IQ-matched typically developing (TD) children. High-density electrophysiology was recorded while participants were presented with either auditory or somatosensory stimuli alone (unisensory conditions), or as a combined auditory somatosensory stimulus (multisensory condition), in randomized order. Participants watched a silent movie during testing, ignoring concurrent stimulation. Significant differences between neural responses to the multisensory auditory somatosensory stimulus and the unisensory stimuli (the sum of the responses to the auditory and somatosensory stimuli when presented alone) served as the dependent measure. The data revealed group differences in the integration of auditory and somatosensory information that appeared at around 175 ms, and were characterized by the presence of MSI for the TD but not the autism spectrum disorder (ASD) children. Overall, MSI was less extensive in the ASD group. These findings are discussed within the framework of current knowledge of MSI in typical development as well as in relation to theories of ASD. C1 [Russo, Natalie; Foxe, John J.; Brandwein, Alice B.; Altschuler, Ted; Molholm, Sophie] Albert Einstein Coll Med, CERC, Dept Pediat, Bronx, NY 10461 USA. [Russo, Natalie; Foxe, John J.; Altschuler, Ted; Gomes, Hilary; Molholm, Sophie] CUNY City Coll, Dept Psychol, Program Cognit Neurosci, Childrens Res Unit, New York, NY 10031 USA. [Russo, Natalie; Foxe, John J.; Altschuler, Ted; Gomes, Hilary; Molholm, Sophie] CUNY City Coll, Dept Biol, Program Cognit Neurosci, Childrens Res Unit, New York, NY 10031 USA. [Foxe, John J.; Brandwein, Alice B.; Gomes, Hilary] CUNY, Queens Coll, Flushing, NY USA. RP Molholm, S (reprint author), Albert Einstein Coll Med, CERC, Dept Pediat, Jack & Pearl Resnick Campus,1300 Morris Pk Ave,Va, Bronx, NY 10461 USA. EM Sophie.Molholm@einstein.yu.edu FU NIH [MH 085322]; Wallace Research Foundation; Cure Autism Now; Fondation du Quebec de Recherche sur la Societe et la Culture; Canadian Institute of Health Research; US National Institute of Mental Health [MH 085322] FX Grant sponsor: NIH; Grant number: MH 085322; Grant sponsors: Wallace Research Foundation; Cure Autism Now; Fondation du Quebec de Recherche sur la Societe et la Culture; Canadian Institute of Health Research.Initial support for this work came from a pilot grant from Cure Autism Now (J.J.F.). Additional support came from the US National Institute of Mental Health (MH 085322 to S.M. and J.J.F.) and The Wallace Research Foundation (S.M. and J.J.F.). NR received additional support from a Post Doctoral Research Grant from the Fondation du Quebec de Recherche sur la Societe et la Culture and from the Autism Research Training Program through the Canadian Institute of Health Research. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT AYERS JA, 1994, SENSORY INTEGRATION Bebko JM, 2006, J CHILD PSYCHOL PSYC, V47, P88, DOI 10.1111/j.1469-7610.2005.01443.x BERMAN AL, 1961, J NEUROPHYSIOL, V24, P595 Bertone A, 2003, J COGNITIVE NEUROSCI, V15, P218, DOI 10.1162/089892903321208150 Bertone A, 2005, BRAIN, V128, P2430, DOI 10.1093/brain/awh561 Bonnel A, 2003, J COGNITIVE NEUROSCI, V15, P226, DOI 10.1162/089892903321208169 Brett-Green BA, 2008, BRAIN RES, V1242, P283, DOI 10.1016/j.brainres.2008.03.090 Brock J, 2002, DEV PSYCHOPATHOL, V14, P209 Carriere BN, 2007, J NEUROPHYSIOL, V98, P2858, DOI 10.1152/jn.00587.2007 Casanova MF, 2007, BRAIN PATHOL, V17, P422, DOI 10.1111/j.1750-3639.2007.00100.x Casanova MF, 2006, NEUROSCIENTIST, V12, P435, DOI 10.1177/1073858406290375 Casanova MF, 2004, ANN NEUROL, V56, P453, DOI 10.1002/ana.20196 CESARONI L, 1991, J AUTISM DEV DISORD, V21, P303, DOI 10.1007/BF02207327 Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c Crane L, 2009, AUTISM, V13, P215, DOI 10.1177/1362361309103794 De Gelder B, 1991, EUROPEAN J COGNITIVE, V3, P69, DOI 10.1080/09541449108406220 Driver J, 1996, NATURE, V381, P66, DOI 10.1038/381066a0 Falchier A, 2002, J NEUROSCI, V22, P5749 FOXE JJ, 2009, BRAIN TOPOGRAPHY, V32, P149 Foxe JJ, 2000, COGNITIVE BRAIN RES, V10, P77, DOI 10.1016/S0926-6410(00)00024-0 Foxe JJ, 2002, J NEUROPHYSIOL, V88, P540, DOI 10.1152/jn.00694.2001 Foxe JJ, 2005, NEUROREPORT, V16, P419, DOI 10.1097/00001756-200504040-00001 FRENS MA, 1995, EXP BRAIN RES, V107, P103 FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8 Giard MH, 1999, J COGNITIVE NEUROSCI, V11, P473, DOI 10.1162/089892999563544 Gori M, 2008, CURR BIOL, V18, P694, DOI 10.1016/j.cub.2008.04.036 Grandin T., 1992, HIGH FUNCTIONING IND, P105 GUTHRIE D, 1991, PSYCHOPHYSIOLOGY, V28, P240, DOI 10.1111/j.1469-8986.1991.tb00417.x Hermelin B, 1970, PSYCHOL EXPT AUTISTI Hotting K, 2004, EXP BRAIN RES, V159, P370, DOI 10.1007/s00221-004-1965-3 JUST M, 2007, CEREB CORTEX, V27, P951 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004 Kim S, 2010, HUM BRAIN MAPP, V31, P678, DOI 10.1002/hbm.20897 Klin A, 1999, J AUTISM DEV DISORD, V29, P499, DOI 10.1023/A:1022299920240 Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028 Lane AE, 2010, J AUTISM DEV DISORD, V40, P112, DOI 10.1007/s10803-009-0840-2 Lewkowicz DJ, 2002, COGNITIVE BRAIN RES, V14, P41, DOI 10.1016/S0926-6410(02)00060-5 Lord C., 1999, AUTISM DIAGNOSTIC OB LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 LOVAAS OI, 1971, BEHAV RES THER, V9, P305, DOI 10.1016/0005-7967(71)90042-8 LOVAAS OI, 1971, J ABNORM PSYCHOL, V77, P211, DOI 10.1037/h0031015 Lutkenhoner B, 2002, NEUROIMAGE, V15, P509, DOI 10.1006/nimg.2001.0991 Ma WJ, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004638 MAGNEE MJ, 2009, NEUROPSYCHOLOGIA, V7, P1728 Magnee MJCM, 2008, J CHILD PSYCHOL PSYC, V49, P995, DOI 10.1111/j.1469-7610.2008.01902.x Mizuno A, 2006, BRAIN RES, V1104, P160, DOI 10.1016/j.brainres.2006.05.064 Molholm S, 2004, CEREB CORTEX, V14, P452, DOI 10.1093/cercor/bhh007 Molholm S, 2002, COGNITIVE BRAIN RES, V14, P115, DOI 10.1016/S0926-6410(02)00066-6 Molholm S, 2007, EUR J NEUROSCI, V26, P499, DOI 10.1111/j.1460-9568.2007.05668.x Mongillo EA, 2008, J AUTISM DEV DISORD, V38, P1349, DOI 10.1007/s10803-007-0521-y Murray MM, 2005, CEREB CORTEX, V15, P963, DOI 10.1093/cercor/bhh197 Nardini M, 2008, CURR BIOL, V18, P689, DOI 10.1016/j.cub.2008.04.021 ONeill M, 1997, J AUTISM DEV DISORD, V27, P283, DOI 10.1023/A:1025850431170 O'Riordan M, 2006, J AUTISM DEV DISORD, V36, P665, DOI 10.1007/s10803-006-0106-1 O'Riordan M, 2001, Q J EXP PSYCHOL-A, V54, P961, DOI 10.1080/02724980042000543 O'Riordan MA, 2004, AUTISM, V8, P229, DOI 10.1177/1362361304045219 Ozonoff S, 1997, J AUTISM DEV DISORD, V27, P59, DOI 10.1023/A:1025821222046 PERROTT DR, 1990, PERCEPT PSYCHOPHYS, V48, P214, DOI 10.3758/BF03211521 Putzar L, 2007, NAT NEUROSCI, V10, P1243, DOI 10.1038/nn1978 Ceponiene R, 2002, CLIN NEUROPHYSIOL, V113, P870, DOI 10.1016/S1388-2457(02)00078-0 Rockland KS, 2003, INT J PSYCHOPHYSIOL, V50, P19, DOI 10.1016/S0167-8760(03)00121-1 Ross LA, 2007, SCHIZOPHR RES, V97, P173, DOI 10.1016/j.schres.2007.08.008 SCHOEN SA, 2009, FRONTIERS INTEGRATIV, V29 Schroeder CE, 2005, CURR OPIN NEUROBIOL, V15, P454, DOI 10.1016/j.conb.2005.06.008 Shams L, 2002, COGNITIVE BRAIN RES, V14, P147, DOI 10.1016/S0926-6410(02)00069-1 Shams L, 2000, NATURE, V408, P788, DOI 10.1038/35048669 Smiley JF, 2009, HEARING RES, V258, P37, DOI 10.1016/j.heares.2009.06.019 Smith EG, 2007, J CHILD PSYCHOL PSYC, V48, P813, DOI 10.1111/j.1469-7610.2007.01766.x Spence C, 1997, PERCEPT PSYCHOPHYS, V59, P389, DOI 10.3758/BF03211906 Sperdin H. F., 2009, FRONTIERS INTEGRATIV, P3, DOI 10.3389/neuro.07.002.2009 Stein B. E., 1990, ANN NY ACAD SCI, V608, P65 Stein BE, 2008, NAT REV NEUROSCI, V9, P255, DOI 10.1038/nrn2331 STEIN BE, 1990, ANN NY ACAD SCI, V608, P51, DOI 10.1111/j.1749-6632.1990.tb48891.x Stein BE, 2009, EXP BRAIN RES, V198, P113, DOI 10.1007/s00221-009-1880-8 STROH G, 1964, BRIT J MED PSYCHOL, V37, P291 TagerFlusberg H, 1996, J AUTISM DEV DISORD, V26, P169, DOI 10.1007/BF02172006 TAGERFLUSBERG H, 1994, J AUTISM DEV DISORD, V24, P577, DOI 10.1007/BF02172139 Talsma D, 2005, J COGNITIVE NEUROSCI, V17, P1098, DOI 10.1162/0898929054475172 Taylor-Clarke M, 2002, CURR BIOL, V12, P233, DOI 10.1016/S0960-9822(01)00681-9 Teder-Salejarvi WA, 2002, COGNITIVE BRAIN RES, V14, P106, DOI 10.1016/S0926-6410(02)00065-4 Tomchek SD, 2007, AM J OCCUP THER, V61, P190 van der Smagt MJ, 2007, J AUTISM DEV DISORD, V37, P2014, DOI 10.1007/s10803-006-0346-0 Vroomen J, 2010, J COGNITIVE NEUROSCI, V22, P1583, DOI 10.1162/jocn.2009.21308 Wallace MT, 2004, J NEUROSCI, V24, P9580, DOI 10.1523/JNEUROSCI.2535-04.2004 Wechsler D, 1999, WECHSLER ABBREVIATED Werner S, 2010, CEREB CORTEX, V20, P1829, DOI 10.1093/cercor/bhp248 Williams D, 1994, SOMEBODY SOMEWHERE ZAHN JR, 1978, SENS PROCESS, V2, P32 NR 90 TC 33 Z9 33 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2010 VL 3 IS 5 BP 253 EP 267 DI 10.1002/aur.152 PG 15 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 677FS UT WOS:000283975100005 PM 20730775 ER PT J AU Wang, L Angley, MT Sorich, MJ Young, RL McKinnon, RA Gerber, JP AF Wang, Lv Angley, Manya T. Sorich, Michael J. Young, Robyn L. McKinnon, Ross A. Gerber, Jacobus P. TI Is There a Role for Routinely Screening Children with Autism Spectrum Disorder for Creatine Deficiency Syndrome? SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder (ASD); creatine deficiency syndrome (CDS); creatine (CR); guanidinoacetate (GAA); liquid chromatography tandem mass spectrometry (LC-MS/MS); diagnostic biomarkers ID CLINICAL CHARACTERISTICS; MENTAL-RETARDATION; INBORN-ERRORS; GUANIDINOACETATE; PREVALENCE; METABOLISM; BRAIN AB Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that presents in the first three years of life. Currently, diagnosis of ASD is based on its behavioural manifestations, as laboratory diagnostic tests do not exist. Creatine deficiency syndrome (CDS) is one form of inborn error of metabolism where affected individuals have similar clinical features to individuals with ASD. Abnormal urinary creatine (CR) and guanidinoacetate (GAA) levels have been reported as biomarkers of CDS. We hypothesized that screening for abnormal levels of urinary CR and GAA in children with ASD may assist in identifying a subgroup of ASD individuals who can be managed with dietary interventions. Morning urine samples were collected from children with and without autism and analyzed for CR and GAA levels. Results showed there was no statistically significant difference in urinary CR:creatinine and GAA:creatinine between the children with ASD and sibling or unrelated controls. In conclusion, routine screening for abnormal urinary CR and GAA could be considered in ASD diagnostic protocols; however, individuals positive for CDS are likely to be rare in an ASD cohort. C1 [Wang, Lv; Angley, Manya T.; Sorich, Michael J.; McKinnon, Ross A.; Gerber, Jacobus P.] Univ S Australia, Sansom Inst, Adelaide, SA 5001, Australia. [Young, Robyn L.] Flinders Univ S Australia, Sch Psychol, Adelaide, SA, Australia. RP Angley, MT (reprint author), Univ S Australia, Sansom Inst, Adelaide, SA 5001, Australia. EM manya.angley@unisa.edu.au RI Sorich, Michael/A-1210-2011; McKinnon, Ross /B-9340-2009; Gerber, Jacobus/F-4423-2013 OI Sorich, Michael/0000-0003-1999-866X; McKinnon, Ross /0000-0002-3725-793X; FU Cure Autism Now FX Grant sponsor: Cure Autism Now. CR Almeida LS, 2006, SYNAPSE, V60, P118, DOI 10.1002/syn.20280 Almeida LS, 2004, MOL GENET METAB, V82, P214, DOI 10.1016/j.ymgme.2004.05.001 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Arias A, 2007, CLIN BIOCHEM, V40, P1328, DOI 10.1016/j.clinbiochem.2007.07.010 Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Baron-Cohen S, 2009, BRIT J PSYCHIAT, V194, P500, DOI 10.1192/bjp.bp.108.059345 Braissant O, 2008, J INHERIT METAB DIS, V31, P230, DOI 10.1007/s10545-008-0826-9 Charman T., 2008, PSYCHIATRY, V7, P331, DOI 10.1016/j.mppsy.2008.05.015 Clark AJ, 2006, HUM GENET, V119, P604, DOI 10.1007/s00439-006-0162-9 Kan HE, 2007, J APPL PHYSIOL, V102, P2121, DOI 10.1152/japplphysiol.01327.2006 Manzi B, 2008, J CHILD NEUROL, V23, P307, DOI 10.1177/0883073807308698 Mercimek-Mahmutoglu S, 2009, MOL GENET METAB, V96, P273, DOI 10.1016/j.ymgme.2008.12.020 Schulze A, 2003, MOL CELL BIOCHEM, V244, P143, DOI 10.1023/A:1022443503883 Schulze A, 1997, J PEDIATR-US, V131, P626, DOI 10.1016/S0022-3476(97)70075-1 Stockler Sylvia, 2007, V46, P149 STOCKLER S, 1994, PEDIATR RES, V36, P409 Stromberger C, 2003, J INHERIT METAB DIS, V26, P299, DOI 10.1023/A:1024453704800 Sykut-Cegielska J, 2004, ACTA BIOCHIM POL, V51, P875 Turk J, 2009, ACTA PAEDIATR, V98, P675, DOI 10.1111/j.1651-2227.2008.01184.x Valongo C, 2004, CLIN CHIM ACTA, V348, P155, DOI 10.1016/j.cccn.2004.05.013 Wang JP, 2006, BIOMED CHROMATOGR, V20, P244, DOI 10.1002/bmc.554 Wang L, 2009, BIOMARKERS, V14, P596, DOI 10.3109/13547500903183962 NR 22 TC 5 Z9 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2010 VL 3 IS 5 BP 268 EP 272 DI 10.1002/aur.145 PG 5 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 677FS UT WOS:000283975100006 PM 20589913 ER PT J AU Damarla, SR Keller, TA Kana, RK Cherkassky, VL Williams, DL Minshew, NJ Just, MA AF Damarla, Saudamini Roy Keller, Timothy A. Kana, Rajesh K. Cherkassky, Vladimir L. Williams, Diane L. Minshew, Nancy J. Just, Marcel Adam TI Cortical Underconnectivity Coupled with Preserved Visuospatial Cognition in Autism: Evidence from an fMRI Study of an Embedded Figures Task SO AUTISM RESEARCH LA English DT Article DE embedded figures task; functional connectivity; corpus callosum; functional MRI ID HIGH-FUNCTIONING AUTISM; CORPUS-CALLOSUM; DISEMBEDDING PERFORMANCE; SENTENCE COMPREHENSION; ASPERGER-SYNDROME; CONNECTIVITY; INDIVIDUALS; CHILDREN; SPECTRUM; MEMORY AB Individuals with high-functioning autism sometimes exhibit intact or superior performance on visuospatial tasks, in contrast to impaired functioning in other domains such as language comprehension, executive tasks, and social functions. The goal of the current study was to investigate the neural bases of preserved visuospatial processing in high-functioning autism from the perspective of the cortical underconnectivity theory. We used a combination of behavioral, functional magnetic resonance imaging, functional connectivity, and corpus callosum morphometric methodological tools. Thirteen participants with high-functioning autism and 13 controls (age-, IQ-, and gender-matched) were scanned while performing an Embedded Figures Task. Despite the ability of the autism group to attain behavioral performance comparable to the control group, the brain imaging results revealed several group differences consistent with the cortical underconnectivity account of autism. First, relative to controls, the autism group showed less activation in the left dorsolateral prefrontal and inferior parietal areas and more activation in visuospatial (bilateral superior parietal extending to inferior parietal and right occipital) areas. Second, the autism group demonstrated lower functional connectivity between higher-order working memory/executive areas and visuospatial regions (between frontal and parietal-occipital). Third, the size of the corpus callosum (an index of anatomical connectivity) was positively correlated with frontal posterior (parietal and occipital) functional connectivity in the autism group. Thus, even in the visuospatial domain, where preserved performance among people with autism is observed, the neuroimaging signatures of cortical underconnectivity persist. C1 [Damarla, Saudamini Roy; Keller, Timothy A.; Kana, Rajesh K.; Cherkassky, Vladimir L.; Williams, Diane L.; Just, Marcel Adam] Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA. [Kana, Rajesh K.] Univ Alabama, Dept Psychol, Birmingham, AL 35294 USA. [Williams, Diane L.] Duquesne Univ, Dept Speech Language Pathol, Pittsburgh, PA 15219 USA. [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA. [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA. RP Just, MA (reprint author), Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA. EM just@cmu.edu FU National Institute of Child Health and Human Development [HD055748]; Autism Speaks Foundation [2294] FX Grant sponsor: National Institute of Child Health and Human Development; Grant number: HD055748; Grant sponsor: Autism Speaks Foundation (Pre-doctoral Training Grant); Grant number: 2294. CR BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548 Brian JA, 1996, J CHILD PSYCHOL PSYC, V37, P865, DOI 10.1111/j.1469-7610.1996.tb01482.x de Jonge MV, 2006, J AUTISM DEV DISORD, V36, P677, DOI 10.1007/s10803-006-0113-2 Frazier TW, 2009, BIOL PSYCHIAT, V66, P935, DOI 10.1016/j.biopsych.2009.07.022 Hardan AY, 2000, NEUROLOGY, V55, P1033 Hollingshead A. B., 1957, 4 FACTOR INDEX SOCIA Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kana RK, 2009, SOC NEUROSCI-UK, V4, P135, DOI 10.1080/17470910802198510 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004 Keller TA, 2007, NEUROREPORT, V18, P23, DOI 10.1097/01.wnr.0000239965.21685.99 KOSHINO H, 2008, CEREB CORTEX, V18, P300 Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028 Lee PS, 2007, NEUROIMAGE, V38, P184, DOI 10.1016/j.neuroimage.2007.07.013 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Manes F, 1999, J NEUROPSYCH CLIN N, V11, P470 Manjaly ZM, 2007, NEUROIMAGE, V35, P283, DOI 10.1016/j.neuroimage.2006.11.036 Mason RA, 2008, NEUROPSYCHOLOGIA, V46, P269, DOI 10.1016/j.neuropsychologia.2007.07.018 Minshew N. J., 1996, PRINCIPLES CHILD NEU, P1713 Mottron L, 2003, J CHILD PSYCHOL PSYC, V44, P904, DOI 10.1111/1469-7610.00174 Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P743, DOI 10.1017/S0021963098003795 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Piven J, 1997, AM J PSYCHIAT, V154, P1051 Quigley M, 2001, AM J NEURORADIOL, V22, P294 Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x Vidal CN, 2006, BIOL PSYCHIAT, V60, P218, DOI 10.1016/j.biopsych.2005.11.011 NR 30 TC 42 Z9 45 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2010 VL 3 IS 5 BP 273 EP 279 DI 10.1002/aur.153 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 677FS UT WOS:000283975100007 PM 20740492 ER PT J AU Leveille, C Barbeau, EB Bolduc, C Limoges, E Berthiaume, C Chevrier, E Mottron, L Godbout, R AF Leveille, Cathy Barbeau, Elise B. Bolduc, Christianne Limoges, Elyse Berthiaume, Claude Chevrier, Elyse Mottron, Laurent Godbout, Roger TI Enhanced Connectivity Between Visual Cortex and Other Regions of the Brain in Autism: A REM Sleep EEG Coherence Study SO AUTISM RESEARCH LA English DT Article DE autism; occipital cortex; REM sleep EEG; EEG coherence; visual perception; neural coupling ID SPECTRUM DISORDER; FUNCTIONAL CONNECTIVITY; CORPUS-CALLOSUM; INDIVIDUALS; FMRI; CHILDREN; TASK AB Functional interregional neural coupling was measured as EEG coherence during REM sleep, a state of endogenous cortical activation, in 9 adult autistic individuals (21.1 +/- 4.0 years) and 13 typically developed controls (21.5 +/- 4.3 years) monitored for two consecutive nights in a sleep laboratory. Spectral analysis was performed on 60s of artefact-free EEG samples distributed equally throughout the first four REM sleep periods of the second night. EEG coherence was calculated for six frequency bands (delta, theta, alpha, sigma, beta, and total spectrum) using a 22-electrode montage. The magnitude of coherence function was computed for intra- and interhemispheric pairs of recording sites. Results were compared by Multivariate Analysis of Variance (MANOVA). Each time the autistic group showed a greater EEG coherence than the controls; it involved intrahemispheric communication among the left visual cortex (O1) and other regions either close to or distant from the occipital cortex. In contrast, lower coherence values involved frontal electrodes in the right hemisphere. No significant differences between groups were found for interhemispheric EEG coherence. These results show that the analysis of EEG coherence during REM sleep can disclose patterns of cortical connectivity that can be reduced or increased in adults with autism compared to typically developed individuals, depending of the cortical areas studied. Superior coherence involving visual perceptual areas in autism is consistent with an enhanced role of perception in autistic brain organization. C1 [Godbout, Roger] Hop Riviere des Prairies, Neurodev Disorders Program, Sleep Lab & Clin, Montreal, PQ H1E 1A4, Canada. [Leveille, Cathy; Barbeau, Elise B.; Bolduc, Christianne; Limoges, Elyse; Berthiaume, Claude; Mottron, Laurent; Godbout, Roger] Hop Riviere des Prairies, Ctr Rech Fernand Seguin, Montreal, PQ H1E 1A4, Canada. [Barbeau, Elise B.; Mottron, Laurent] Hop Riviere des Prairies, Autism Ctr Excellence, Montreal, PQ H1E 1A4, Canada. [Mottron, Laurent; Godbout, Roger] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada. RP Godbout, R (reprint author), Hop Riviere des Prairies, Neurodev Disorders Program, Sleep Lab & Clin, 7070 Boul Perras, Montreal, PQ H1E 1A4, Canada. EM roger.godbout@umontreal.ca RI Sanguansri, Luz/B-6630-2011 OI Sanguansri, Luz/0000-0003-1908-7604 FU Canadian Institutes of Health Research, Fonds de la recherche en sante du Quebec; Canadian Institutes of Health Research (CIHR) [81898]; Fonds de la recherche en sante du Quebec (FRSQ) FX Grant sponsor: Canadian Institutes of Health Research, Fonds de la recherche en sante du Quebec.This work was supported by an operating grant from the Canadian Institutes of Health Research (CIHR, No. 81898, Studies of Sleep, EEG, and Cognitive Performance in Autism) to R. Godbout and L. Mottron, a studentship from the Fonds de la recherche en sante du Quebec (FRSQ) to C. Leveille, studentships from the CIHR to E.B. Barbeau, C. Bolduc and E. Limoges, and a research scholarship from the FRSQ to L. Mottron. The authors want to thank the participants for their invaluable contribution to this project. CR Alexander AL, 2007, NEUROIMAGE, V34, P61, DOI 10.1016/j.neuroimage.2006.08.032 *AM EL SOC, 1994, AM GUID 13 GUID STAN Bailey AJ, 2005, EUR J NEUROSCI, V21, P2575, DOI 10.1111/j.1460-9568.2005.04061.x CANTOR DS, 1986, J AUTISM DEV DISORD, V16, P169, DOI 10.1007/BF01531728 Coben R, 2008, CLIN NEUROPHYSIOL, V119, P1002, DOI 10.1016/j.clinph.2008.01.013 Courchesne E, 2005, CURR OPIN NEUROBIOL, V15, P225, DOI 10.1016/j.conb.2005.03.001 Daoust AM, 2004, CLIN NEUROPHYSIOL, V115, P1368, DOI 10.1016/j.clinph.2004.01.011 DAWSON G, 1995, J ABNORM CHILD PSYCH, V23, P569, DOI 10.1007/BF01447662 Dawson M, 2007, PSYCHOL SCI, V18, P657, DOI 10.1111/j.1467-9280.2007.01954.x Gaffrey MS, 2007, NEUROPSYCHOLOGIA, V45, P1672, DOI 10.1016/j.neuropsychologia.2007.01.008 Gage NM, 2009, J NEURODEV DISORD, V1, P205, DOI 10.1007/s11689-009-9010-2 Herbert MR, 2005, BRAIN, V128, P213, DOI 10.1093/brain/awh330 Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 McPartland J, 2004, J CHILD PSYCHOL PSYC, V45, P1235, DOI 10.1111/j.1469-7610.2004.00318.x Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 Murias M, 2007, BIOL PSYCHIAT, V62, P270, DOI 10.1016/j.biopsych.2006.11.012 Nunez PL, 1997, ELECTROEN CLIN NEURO, V103, P499, DOI 10.1016/S0013-4694(97)00066-7 PETSCHE H, 1988, FUNCTIONAL BRAIN IMAGING, P161 PIVIK RT, 1993, PSYCHOPHYSIOLOGY, V30, P547, DOI 10.1111/j.1469-8986.1993.tb02081.x RAFELSON W, 2008, 7 ANN INT M AUT RES SHAW JC, 1981, J MED ENG TECHNOL, V5, P279, DOI 10.3109/03091908109009362 Soulieres I, 2009, HUM BRAIN MAPP, V30, P4082, DOI 10.1002/hbm.20831 STERIADE M, 1993, SCIENCE, V262, P679, DOI 10.1126/science.8235588 NR 27 TC 21 Z9 21 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2010 VL 3 IS 5 BP 280 EP 285 DI 10.1002/aur.155 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 677FS UT WOS:000283975100008 PM 20717953 ER PT J AU Libbey, JE Fujinami, RS AF Libbey, Jane E. Fujinami, Robert S. TI Role for Antibodies in Altering Behavior and Movement SO AUTISM RESEARCH LA English DT Review DE antibody; autism; chorea; Immoral immunity; systemic lupus erythematosus ID AUTOIMMUNE NEUROPSYCHIATRIC DISORDERS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; AUTISM SPECTRUM DISORDERS; CALMODULIN KINASE-II; MULTIPLE-SCLEROSIS; MOLECULAR MIMICRY; SYDENHAMS CHOREA; FETAL-BRAIN; BYSTANDER ACTIVATION; MUTANT MICE AB At the past meeting of INSAR, the role of autoimmunity was discussed in an educational session. This article summarizes this discussion. In immune-mediated diseases, antibodies can contribute to the pathogenesis of the disease and are sometimes the force that drives the disease process. This concept has not been established for autism. In autoimmune diseases, such as systemic lupus erythematosus (SLE), antibodies are found to react with double-stranded DNA. These antibodies also cross-react with N-methyl-D aspartate receptors. Many SLE patients suffer neurologic syndromes of the central nervous system (CNS). Similarly individuals infected with Group A streptococcus (GAS) have antibodies against the GAS carbohydrate, which cross-react with tubulin and lysoganglioside GM1 on neurons. During the acute stage of infection, GAS-infected patients develop Syndenham chorea where the disease process is driven in part by these cross-reactive antibodies. As the antibody levels decrease, the clinical features of Syndenham chorea resolve. In these two immune-mediated diseases, antibodies clearly play a role in the pathogenesis of the diseases. There are reports that mothers of individuals with autism have antibodies that react with brain proteins and when these antibodies are passively transferred to pregnant non-human primates or rodents the offspring has behavioral and nervous system changes. It is still not clear whether the antibodies found in mothers of individuals with autism actually play a role in the disease. More studies need to be performed to identify the proteins recognized by the antibodies and to determine how these could affect development, behavior and changes within the CNS. C1 [Libbey, Jane E.; Fujinami, Robert S.] Univ Utah, Dept Pathol, Salt Lake City, UT 84132 USA. RP Fujinami, RS (reprint author), Univ Utah, Dept Pathol, 30 North 1900 East,3R330 SOM, Salt Lake City, UT 84132 USA. EM Robert.Fujinami@hsc.utah.edu FU Autism Speaks [2728]; Emma Mary Deland Foundation FX Grant sponsor: Autism Speaks; Grant number: 2728; Grant sponsor: Emma Mary Deland Foundation. CR ACR Ad Hoc Committee on Neuropsychiatric Lupus Nomenclature, 1999, ARTHRITIS RHEUM, V42, P599 Braunschweig D, 2008, NEUROTOXICOLOGY, V29, P226, DOI 10.1016/j.neuro.2007.10.010 CHEN C, 1994, SCIENCE, V266, P291, DOI 10.1126/science.7939668 Croen LA, 2008, BIOL PSYCHIAT, V64, P583, DOI 10.1016/j.biopsych.2008.05.006 Dalton P, 2003, ANN NEUROL, V53, P533, DOI 10.1002/ana.10557 DeGiorgio LA, 2001, NAT MED, V7, P1189, DOI 10.1038/nm1101-1189 Diamond B, 2009, NAT REV IMMUNOL, V9, P449, DOI 10.1038/nri2529 Enstrom AM, 2009, CURR OPIN INVEST DR, V10, P463 Fujinami Robert S., 1996, P507, DOI 10.1016/B978-044482383-0/50078-9 Fujinami RS, 2001, TRENDS MICROBIOL, V9, P377, DOI 10.1016/S0966-842X(01)02097-2 Fujinami RS, 2006, CLIN MICROBIOL REV, V19, P80, DOI 10.1128/CMR.19.1.80-94.2006 Fujinami RS, 2000, MOLECULAR MIMICRY, MICROBES, AND AUTOIMMUNITY, P27 Fujinami RS, 1998, AUTOIMMUNE DISEASES, THIRD EDITION, P141 GIACOIA GP, 1992, SOUTHERN MED J, V85, P139 Giedd JN, 1996, J AM ACAD CHILD PSY, V35, P913, DOI 10.1097/00004583-199607000-00017 Halladay AK, 2009, NEUROTOXICOLOGY, V30, P811, DOI 10.1016/j.neuro.2009.07.002 Hoftman Alice Chang, 2008, Adv Pediatr, V55, P271 Huerta PT, 2006, P NATL ACAD SCI USA, V103, P678, DOI 10.1073/pnas.0510055103 Jankovic M, 2004, ANNU REV IMMUNOL, V22, P485, DOI 10.1146/annurev.immunol.22.012703.104707 Kirvan CA, 2006, J NEUROIMMUNOL, V179, P173, DOI 10.1016/j.jneuroim.2006.06.017 Kirvan CA, 2006, AUTOIMMUNITY, V39, P21, DOI 10.1080/08916930500484757 Kirvan CA, 2007, J IMMUNOL, V178, P7412 Kirvan CA, 2003, NAT MED, V9, P914, DOI 10.1038/nm892 Kowal C, 2004, IMMUNITY, V21, P179, DOI 10.1016/j.immuni.2004.07.011 Kowal C, 2006, P NATL ACAD SCI USA, V103, P19854, DOI 10.1073/pnas.0608397104 Kristoffersen EK, 2000, TRANSFUS MED REV, V14, P234, DOI 10.1053/tm.2000.7393 Lapteva L, 2006, ARTHRITIS RHEUM, V54, P2505, DOI 10.1002/art.22031 Lee JY, 2009, NAT MED, V15, P91, DOI 10.1038/nm.1892 Libbey JE, 2007, INT REV NEUROBIOL, V79, P127, DOI 10.1016/S0074-7742(07)79006-2 Martin LA, 2008, BRAIN BEHAV IMMUN, V22, P806, DOI 10.1016/j.bbi.2007.12.007 McCoy L, 2006, AUTOIMMUNITY, V39, P9, DOI 10.1080/08916930500484799 Monson NL, 2008, CURR OPIN NEUROL, V21, pS3, DOI 10.1097/01.wco.0000313358.53553.c7 MORPHIS LG, 1970, NATURE, V228, P573, DOI 10.1038/228573a0 Palestini P, 2000, J BIOL CHEM, V275, P9978, DOI 10.1074/jbc.275.14.9978 PETERSON LK, 2006, AUTOANTIBODIES, P13 Ribatti Domenico, 2006, Anatomical Record Part B:The New Anatomist, V289, P3, DOI 10.1002/ar.b.20087 ROSE NR, 1993, IMMUNOL TODAY, V14, P426, DOI 10.1016/0167-5699(93)90244-F Schulman H, 1995, Prog Brain Res, V105, P95 SILVA AJ, 1992, SCIENCE, V257, P201, DOI 10.1126/science.1378648 Singer HS, 2008, J NEUROIMMUNOL, V194, P165, DOI 10.1016/j.jneuroim.2007.11.004 Singer HS, 2009, J NEUROIMMUNOL, V211, P39, DOI 10.1016/j.jneuroim.2009.03.011 Sospedra M, 2005, ANNU REV IMMUNOL, V23, P683, DOI 10.1146/annurev.immunol.23.021704.115707 SWEDO SE, 1994, PEDIATRICS, V93, P323 Swedo SE, 1997, AM J PSYCHIAT, V154, P110 SWEDO SE, 1994, JAMA-J AM MED ASSOC, V272, P1788, DOI 10.1001/jama.272.22.1788 TILLAKARATNE NJK, 1995, COMP BIOCHEM PHYS A, V112, P247, DOI 10.1016/0300-9629(95)00099-2 Uchiyama S, 2009, J EXP MED, V206, P1845, DOI 10.1084/jem.20090386 von Herrath MG, 2003, NAT REV MICROBIOL, V1, P151, DOI 10.1038/nrmicro754 Whitton JL, 1999, CURR OPIN MICROBIOL, V2, P392 Wills S, 2009, BRAIN BEHAV IMMUN, V23, P64, DOI 10.1016/j.bbi.2008.07.007 Wills S, 2007, ANN NY ACAD SCI, V1107, P79, DOI 10.1196/annals.1381.009 Zhao WQ, 1999, J NEUROSCI RES, V55, P557, DOI 10.1002/(SICI)1097-4547(19990301)55:5<557::AID-JNR3>3.0.CO;2-P NR 52 TC 7 Z9 7 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2010 VL 3 IS 4 BP 147 EP 152 DI 10.1002/aur.144 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 643RN UT WOS:000281316200001 PM 20589715 ER PT J AU Huang, HS Cheung, I Akbarian, S AF Huang, Hsien-Sung Cheung, Iris Akbarian, Schahram TI RPP25 is Developmentally Regulated in Prefrontal Cortex and Expressed at Decreased Levels in Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE developmental neurobiology; molecular genetics; GABA ID MESSENGER-RNA EXPRESSION; DNA-METHYLATION; BRAIN-TISSUE; ASSOCIATION; FOREBRAIN; GENES; SCHIZOPHRENIA; INTERNEURONS; DYSFUNCTION; LINKAGE AB Dysfunction of cerebral cortex in autism is thought to involve alterations in inhibitory neurotransmission. Here, we screened, in prefrontal cortex (PFC) of 15 subjects diagnosed with autism and 15 matched controls the expression of 44 transcripts that are either preferentially expressed in gamma-aminobutyric acidergic intemeurons of the mature cortex or important for the development of inhibitory circuitry. Significant alterations in the autism cohort included decreased expression (-45%) of RPP25 (15q24.1) which is located within the autism susceptibility locus, 15q22-26. RPP25, which encodes the 25 kDa subunit of ribonuclease P involved in tRNA and pre-ribosomal RNA processing, was developmentally regulated in cerebral cortex with peak levels of expression during late fetal development (human) or around birth (mouse). In the PFC, RPP25 chromatin showed high levels of histone H3-lysine 4 trimethylation, an epigenetic mark associated with transcriptional regulation. Unexpectedly, and in contrast to peripheral tissues, levels of RPP25 protein remained undetectable in fetal and adult cerebral cortex. Taken together, these findings suggest a potential role for the RPP25 gene transcript in the neurobiology of developmental brain disorders. C1 [Huang, Hsien-Sung; Cheung, Iris; Akbarian, Schahram] Brudnick Neuropsychiat Res Inst, Dept Psychiat, Worcester, MA 01604 USA. [Huang, Hsien-Sung] Univ Massachusetts, Sch Med, Grad Sch Biomed Sci, Worcester, MA USA. RP Akbarian, S (reprint author), Brudnick Neuropsychiat Res Inst, Dept Psychiat, 303 Belmont St, Worcester, MA 01604 USA. EM schahram.akbarian@umassmed.edu FU NICHD [NO1-HD-8-3284]; National Institute of Child Health and Human Development [HD048489]; National Alliance for Autism Research (NAAR)/Autism Speaks FX Grant sponsor: NICHD; Grant number: NO1-HD-8-3284; Grant sponsor: National Institute of Child Health and Human Development; Grant number: HD048489; Grant sponsor: National Alliance for Autism Research (NAAR)/Autism Speaks. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Akbarian S, 2006, BRAIN RES REV, V52, P293, DOI 10.1016/j.brainresrev.2006.04.001 Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180 Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552 Cobos I., 2006, CEREB CORTEX S1, V1, pi82, DOI 10.1093/cercor/bhk003 Cobos I, 2005, J COMP NEUROL, V483, P292, DOI 10.1002/cne.20405 Cook EH, 1998, AM J HUM GENET, V62, P1077, DOI 10.1086/301832 Delahanty RJ, 2011, MOL PSYCHIATR, V16, P86, DOI 10.1038/mp.2009.118 Fatemi SH, 2009, CEREBELLUM, V8, P64, DOI 10.1007/s12311-008-0075-3 Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0 Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7 Gant JC, 2009, EPILEPSIA, V50, P629, DOI 10.1111/j.1528-1167.2008.01725.x Guerrier-Takada C, 2002, RNA, V8, P290, DOI 10.1017/S1355838202027954 Haroutunian V, 2007, BRAIN PATHOL, V17, P412, DOI 10.1111/j.1750-3639.2007.00097.x Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003 Hogart A, 2009, J MED GENET, V46, P86, DOI 10.1136/jmg.2008.061580 Huang HS, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000809 Huang HS, 2007, J NEUROSCI, V27, P11254, DOI 10.1523/JNEUROSCI.3272-07.2007 Jiang Y, 2008, BMC NEUROSCI, V9, DOI 10.1186/1471-2202-9-42 Kato M, 2004, HUM MUTAT, V23, P147, DOI 10.1002/humu.10310 Kemper TL, 2002, MOL PSYCHIATR, V7, pS12, DOI 10.1038/sj.mp.4001165 Kumar RA, 2008, HUM MOL GENET, V17, P628, DOI 10.1093/hmg/ddm376 Laeng P, 2004, J NEUROCHEM, V91, P238, DOI 10.1111/j.1471-4159.2004.02725.x LAWRENCE VA, 2010, ACTA NEUROL SCAND, V121, P99 Le TN, 2007, J BIOL CHEM, V282, P19071, DOI 10.1074/jbc.M607486200 Lein ES, 2007, NATURE, V445, P168, DOI 10.1038/nature05453 Lingarde B, 2000, EUR CHILD ADOLES PSY, V9, P21 Lipska BK, 2006, BIOL PSYCHIAT, V60, P650, DOI 10.1016/j.biopsych.2006.06.019 Liu XD, 2009, EUR J HUM GENET, V17, P228, DOI 10.1038/ejhg.2008.148 Martin-Ruiz CM, 2004, MOL BRAIN RES, V123, P81, DOI 10.1016/j.molbrainres.2004.01.003 McCauley JL, 2004, AM J MED GENET B, V131B, P51, DOI 10.1002/ajmg.b.30038 Mellios N, 2008, HUM MOL GENET, V17, P3030, DOI 10.1093/hmg/ddn201 Mill J, 2008, AM J HUM GENET, V82, P696, DOI 10.1016/j.ajhg.2008.01.008 Morrow EM, 2008, SCIENCE, V321, P218, DOI 10.1126/science.1157657 Oblak A, 2009, AUTISM RES, V2, P205, DOI 10.1002/aur.88 Paradis S, 2007, NEURON, V53, P217, DOI 10.1016/j.neuron.2006.12.012 Poirier K, 2004, MOL BRAIN RES, V122, P35, DOI 10.1016/j.molbrainres.2003.11.021 Purcell AE, 2001, NEUROLOGY, V57, P1618 RITVO ER, 1986, AM J PSYCHIAT, V143, P862 Salimi K, 2008, SYNAPSE, V62, P273, DOI 10.1002/syn.20492 Samaco RC, 2005, HUM MOL GENET, V14, P483, DOI 10.1093/hmg/ddi045 Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846 Shilatifard A, 2008, CURR OPIN CELL BIOL, V20, P341, DOI 10.1016/j.ceb.2008.03.019 Sohal VS, 2009, NATURE, V459, P698, DOI 10.1038/nature07991 Sugino K, 2006, NAT NEUROSCI, V9, P99, DOI 10.1038/nn1618 Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 Turner G, 2002, AM J MED GENET, V112, P405, DOI 10.1002/ajmg.10714 Webster MJ, 2002, DEV BRAIN RES, V139, P139, DOI 10.1016/S0165-3806(02)00540-0 Weickert CS, 2007, NEUROSCIENCE, V144, P1109, DOI 10.1016/j.neuroscience.2006.10.009 Weiss LA, 2008, NEW ENGL J MED, V358, P667, DOI 10.1056/NEJMoa075974 Welting TJM, 2007, RNA, V13, P65, DOI 10.1261/rna.237807 Welting TJM, 2006, RNA, V12, P1373, DOI 10.1261/rna.2293906 Wonders CP, 2006, NAT REV NEUROSCI, V7, P687, DOI 10.1038/nrn1954 Wu SP, 2007, AM J MED GENET B, V144B, P492, DOI 10.1002/ajmg.b.30495 Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3 Yip J, 2008, J NEUROSCI RES, V86, P525, DOI 10.1002/jnr.21520 Yip J, 2009, AUTISM RES, V2, P50, DOI 10.1002/aur.62 NR 58 TC 0 Z9 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2010 VL 3 IS 4 BP 153 EP 161 DI 10.1002/aur.141 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 643RN UT WOS:000281316200002 PM 20632321 ER PT J AU Kim, SH Lord, C AF Kim, So Hyun Lord, Catherine TI Restricted and Repetitive Behaviors in Toddlers and Preschoolers with Autism Spectrum Disorders Based on the Autism Diagnostic Observation Schedule (ADOS) SO AUTISM RESEARCH LA English DT Article DE restricted and repetitive behaviors (RRBs); autism spectrum disorders (ASD); Autism Diagnostic Observation Schedule (ADOS); toddlers; preschoolers ID ASPERGER-SYNDROME; CHILDREN; AGE; ASSOCIATION; INTERESTS AB Restricted and repetitive behaviors (RRBs) observed during the Autism Diagnostic Observation Schedule [ADOS: Lord et al., 2000] were examined in a longitudinal data set of 455 toddlers and preschoolers (age 8-56 months) with clinical diagnosis of Autism Spectrum Disorders (ASD; autism, n = 121 and pervasive developmental disorders not otherwise specified (PDD-NOS), n = 71), a nonspectrum disorder (NS; n = 90), or typical development (TD; n = 173). Even in the relatively brief semi-structured observations, GEE analyses of the severity and prevalence of RRBs differentiated children with ASD from those with NS and TD across all ages. RRB total scores on the ADOS were stable over time for children with ASD and NS; however, typically developing preschoolers showed lower RRB scores than typically developing toddlers. Nonverbal IQ (NVIQ) was more strongly related to the prevalence of RRBs in older children with MD-NOS, NS, and TD than younger children under 2 years and those with autism. Item analyses revealed different relationships between individual items and NVIQ age, diagnosis, and gender. These findings are discussed in terms of their implications for the etiology and treatment of RRBs as well as for the framework of ASD diagnostic criteria in future diagnostic systems. C1 [Kim, So Hyun; Lord, Catherine] Univ Michigan Autism & Commun Disorders Ctr UMACC, Ann Arbor, MI USA. RP Kim, SH (reprint author), UMACC, 1111 Catherine St, Ann Arbor, MI 48109 USA. EM sohkim@umich.edu FU National Institute of Mental Health (NIMH); National Institute of Child Health and Human Development (NICHD); Department of Education (DOE); Simons Foundation [R01 MH 066496, R01 MH081873, H324C030112] FX Grant sponsors: National Institute of Mental Health (NIMH); National Institute of Child Health and Human Development (NICHD); Department of Education (DOE); Simons Foundation; Grant numbers: R01 MH 066496; R01 MH081873; H324C030112. CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Bayley N, 1993, BAYLEY SCALES INFANT Bishop SL, 2006, CHILD NEUROPSYCHOL, V12, P247, DOI 10.1080/09297040600630288 Charman T, 2002, J CHILD PSYCHOL PSYC, V43, P289, DOI 10.1111/1469-7610.00022 Chawarska K, 2007, J CHILD PSYCHOL PSYC, V48, P128, DOI 10.1111/j.1469-7610.2006.01685.x Cuccaro ML, 2003, CHILD PSYCHIAT HUM D, V34, P3, DOI 10.1023/A:1025321707947 DILAVORE PC, 1995, J AUTISM DEV DISORD, V25, P355, DOI 10.1007/BF02179373 Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P57, DOI 10.1007/s10803-008-0599-x Evans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925 Georgiades S, 2007, J AM ACAD CHILD PSY, V46, P188, DOI 10.1097/01.chi.0000242236.90763.7f Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Howlin P, 2004, J CHILD PSYCHOL PSYC, V45, P212, DOI 10.1111/j.1469-7610.2004.00215.x Hus V, 2007, BIOL PSYCHIAT, V61, P438, DOI 10.1016/j.biopsych.2006.08.044 Kanner L, 1943, NERV CHILD, V2, P217 Klin A, 2005, J AUTISM DEV DISORD, V35, P221, DOI 10.1007/s10803-005-2001-6 Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x Loh A, 2007, J AUTISM DEV DISORD, V37, P25, DOI 10.1007/s10803-006-0333-5 Lord C, 2006, ARCH GEN PSYCHIAT, V63, P694, DOI 10.1001/archpsyc.63.6.694 Lord C, 2010, AUTISM DIAGNOSTIC OB Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Luyster R, 2009, J AUTISM DEV DISORD, V39, P1305, DOI 10.1007/s10803-009-0746-z Militerni R, 2002, EUR CHILD ADOLES PSY, V11, P210, DOI 10.1007/s00787-002-0279-x Moore V, 2003, AUTISM, V7, P47, DOI 10.1177/1362361303007001018 Morgan L, 2008, J CHILD PSYCHOL PSYC, V49, P826, DOI 10.1111/j.1469-7610.2008.01904.x Mullen E, 1995, MULLEN SCALES EARLY Richler J, 2007, J AUTISM DEV DISORD, V37, P73, DOI 10.1007/s10803-006-0332-6 Richler J, 2010, DEV PSYCHOPATHOL, V22, P55, DOI 10.1017/S0954579409990265 Rutter M., 2003, AUTISM DIAGNOSTIC IN SALLUSTRO F, 1978, J PEDIATR-US, V93, P704, DOI 10.1016/S0022-3476(78)80922-6 South M, 2005, J AUTISM DEV DISORD, V35, P145, DOI 10.1007/s10803-005-1992-3 Stone WL, 1999, J CHILD PSYCHOL PSYC, V40, P219, DOI 10.1017/S0021963098003370 Szatmari P, 2006, J CHILD PSYCHOL PSYC, V47, P582, DOI 10.1111/j.1469-7610.2005.01537.x THELEN E, 1979, ANIM BEHAV, V27, P699, DOI 10.1016/0003-3472(79)90006-X Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278 Ventola PE, 2006, J AUTISM DEV DISORD, V36, P839, DOI 10.1007/s10803-006-0128-8 Watson LR, 2007, J AUTISM DEV DISORD, V37, P49, DOI 10.1007/s10803-006-0334-4 WHO, 1990, INT CLASS DIS NR 37 TC 28 Z9 28 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2010 VL 3 IS 4 BP 162 EP 173 DI 10.1002/aur.142 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 643RN UT WOS:000281316200003 PM 20589716 ER PT J AU Valla, JM Ganzel, BL Yoder, KJ Chen, GM Lyman, LT Sidari, AP Keller, AE Maendel, JW Perlman, JE Wong, SKL Belmonte, MK AF Valla, Jeffrey M. Ganzel, Barbara L. Yoder, Keith J. Chen, Grace M. Lyman, Laura T. Sidari, Anthony P. Keller, Alex E. Maendel, Jeffrey W. Perlman, Jordan E. Wong, Stephanie K. L. Belmonte, Matthew K. TI More Than Maths and Mindreading: Sex Differences in Empathizing/Systemizing Covariance SO AUTISM RESEARCH LA English DT Article DE empathizing; systemizing; extreme male brain; mindreading; cognitive style; normal cognitive variation ID SPECTRUM QUOTIENT AQ; ASPERGER-SYNDROME; COGNITIVE PHENOTYPE; FUNCTIONING AUTISM; GENERAL-POPULATION; CENTRAL COHERENCE; DIGIT RATIO; EYES TEST; MIND; TESTOSTERONE AB Empathizing Systemizing theory posits a continuum of cognitive traits extending from autism into normal cognitive variation. Covariance data on empathizing and systemizing traits have alternately suggested inversely dependent, independent, and sex-dependent (one sex dependent, the other independent) structures. A total of 144 normal undergraduates (65 men, 79 women) completed the Reading the Mind in the Eyes, Embedded Figures, and Benton face recognition tests, the Autism Spectrum Quotient, and measures of digit length ratio and field of study; some also completed tests of motion coherence threshold (64) and go/no-go motor inhibition (128). Empathizing and systemizing traits were independent in women, but largely dependent in men. In men, level of systemizing skill required by field of study was directly related to social interactive and mindreading deficits; men's social impairments correlated with prolonged go/no-go response times, and men tended to apply systemizing strategies to solve problems of empathizing or global processing: rapid perceptual disembedcling predicted heightened sensitivity to facial emotion. In women, level of systemizing in field was related to male-typical digit ratios and autistic superiorities in detail orientation, but not to autistic social and communicative impairments; and perceptual disembedding was related to social interactive skills but independent of facial emotion and visual motion perception. C1 [Valla, Jeffrey M.; Ganzel, Barbara L.; Yoder, Keith J.; Chen, Grace M.; Lyman, Laura T.; Sidari, Anthony P.; Keller, Alex E.; Maendel, Jeffrey W.; Perlman, Jordan E.; Wong, Stephanie K. L.; Belmonte, Matthew K.] Cornell Univ, Dept Human Dev, Ithaca, NY 14853 USA. RP Valla, JM (reprint author), Cornell Univ, Dept Human Dev, Ithaca, NY 14853 USA. EM jmv34@cornell.edu FU Autism Speaks Pilot Research Grant [2597]; US National Science Foundation [BCS-0846892] FX Grant sponsor: Autism Speaks Pilot Research Grant; Grant number: 2597; Grant sponsor: US National Science Foundation Faculty Early Career Development Award; Grant number: BCS-0846892. CR Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022 Baron-Cohen S, 1997, ADV INFANCY RES, V11, P193 Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 BaronCohen S, 1997, J COGNITIVE NEUROSCI, V9, P548, DOI 10.1162/jocn.1997.9.4.548 Baron-Cohen S, 2004, PRENATAL TESTOSTERON Baron-Cohen S, 2002, TRENDS COGN SCI, V6, P248, DOI 10.1016/S1364-6613(02)01904-6 Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643 Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY Belmonte MK, 2003, COGNITIVE BRAIN RES, V17, P651, DOI 10.1016/S0926-6410(03)00189-7 BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289 Benton A. L., 1983, CONTRIBUTIONS NEUROP Carroll JM, 2006, J AUTISM DEV DISORD, V36, P949, DOI 10.1007/s10803-006-0127-9 Chakrabarti B, 2009, AUTISM RES, V2, P157, DOI 10.1002/aur.80 Charman T, 2003, PHILOS T ROY SOC B, V358, P315, DOI 10.1098/rstb.2002.1199 Dawson G, 2002, DEV PSYCHOPATHOL, V14, P581, DOI 10.1017/S0954579402003103 Falter CM, 2006, BIOL PSYCHOL, V73, P132, DOI 10.1016/j.biopsycho.2006.01.011 Frith U., 1989, AUTISM EXPLAINING EN FRITH U, 1994, COGNITION, V50, P115, DOI 10.1016/0010-0277(94)90024-8 Happe F, 2001, J CHILD PSYCHOL PSYC, V42, P299, DOI 10.1111/1469-7610.00723 Happe F, 2006, NAT NEUROSCI, V9, P1218, DOI 10.1038/nn1770 Hoekstra RA, 2008, J AUTISM DEV DISORD, V38, P1555, DOI 10.1007/s10803-008-0538-x Jarrold C, 2000, DEV PSYCHOL, V36, P126, DOI 10.1037/0012-1649.36.1.126 Kempel P, 2005, INTELLIGENCE, V33, P215, DOI 10.1016/j.intell.2004.11.004 Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X Lutchmaya S, 2004, EARLY HUM DEV, V77, P23, DOI 10.1016/j.earlhumdev.2003.12.002 Manning JT, 2001, DEV MED CHILD NEUROL, V43, P160, DOI 10.1017/S0012162201000317 OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x PENTLAND A, 1980, PERCEPT PSYCHOPHYS, V28, P377, DOI 10.3758/BF03204398 Piven J, 1999, INT REV PSYCHIATR, V11, P299, DOI 10.1080/09540269974186 Romano M, 2006, BIOL PSYCHOL, V71, P175, DOI 10.1016/j.biopsycho.2005.03.006 Voracek M, 2006, PERS INDIV DIFFER, V41, P1481, DOI 10.1016/j.paid.2006.06.009 Walter E., 2008, J AUTISM DEV DISORD, V39, P339 Williams VSL, 1999, J EDUC BEHAV STAT, V24, P42, DOI 10.2307/1165261 Witkin HA, 1971, MANUAL EMBEDDED FIGU NR 34 TC 19 Z9 21 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2010 VL 3 IS 4 BP 174 EP 184 DI 10.1002/aur.143 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 643RN UT WOS:000281316200004 PM 20589713 ER PT J AU Hebert, KJ Miller, LL Joinson, CJ AF Hebert, Karen J. Miller, Laura L. Joinson, Carol J. TI Association of Autistic Spectrum Disorder with Season of Birth and Conception in a UK Cohort SO AUTISM RESEARCH LA English DT Article DE autistic spectrum disorder; season; birth; conception; ALSPAC ID INFANTILE-AUTISM; SCHIZOPHRENIA; CHILDREN; METHODOLOGY; PREVALENCE; FICTION; RISK AB Purpose: To examine the association between autistic spectrum disorder (ASD) and seasons of conception and birth in a UK birth cohort: Avon Longitudinal Study of Parents and Children (ALSPAC). Methods: Seasons of conception and birth were compared in children with and without ASD with season grouped as follows: spring (March May); summer (June August); autumn (September November) and winter (December February). Results: A total of 86 children with ASD were identified in the ALSPAC cohort giving a prevalence of ASD of 61.9 per 10,000. There was some evidence for an excess of children with ASD being conceived during the summer months with a rate per 1,000 conceptions of 9.5 in summer compared to 5.1, 4.6, 5.7 in spring, autumn and winter, respectively. A doubling of the odds was suggested for summer compared to autumn (Odds ratio 2.08 [1.18, 3.70]). In agreement with previous research, there was a corresponding peak in spring births. Conclusion: Conception during the summer months was associated with an over-representation of children with ASD in this UK birth cohort. There was also an association between ASD and spring births. Further investigation of seasonal influences on the aetiology of autism is required to identify possible factors in the environment, and their mechanisms and timings. C1 [Miller, Laura L.] Univ Bristol, ALSPAC, Dept Social Med, Bristol BS8 2BN, Avon, England. [Hebert, Karen J.] Vantage Off Pk Hambrook, Deanery House Unit D, Bristol, Avon, England. [Joinson, Carol J.] Univ Bristol, Dept Community Based Med, Bristol, Avon, England. RP Miller, LL (reprint author), Univ Bristol, ALSPAC, Dept Social Med, Oakfield House,Oakfield Grove, Bristol BS8 2BN, Avon, England. EM L.L.Miller@bristol.ac.uk FU Medical Research Council [G0400085/69351] FX Grant sponsor: MRC; Grant number: G0400085/69351.We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. The UK Medical Research Council, the Wellcome Trust and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors who also serve as guarantors for the contents of this paper. This research was specifically funded by a grant from the Medical Research Council. CR Atladottir HO, 2007, EPIDEMIOLOGY, V18, P240, DOI 10.1097/01.ede.0000254064.92806.13 BARAK Y, 1995, AM J PSYCHIAT, V152, P798 Bartlik B D, 1981, J Am Med Womens Assoc, V36, P363 Bodnar LM, 2008, PAEDIATR PERINAT EP, V22, P538, DOI 10.1111/j.1365-3016.2008.00971.x BOLTON P, 1992, J CHILD PSYCHOL PSYC, V33, P509, DOI 10.1111/j.1469-7610.1992.tb00888.x BRADBURY TN, 1985, PSYCHOL BULL, V98, P569, DOI 10.1037//0033-2909.98.3.569 Brown AS, 2000, SCHIZOPHRENIA BULL, V26, P287 Department for Education and Skills (DfES), 2001, DFES5812001 *DFES, 2003, DFES05362003 GILLBERG C, 1990, ACTA PSYCHIAT SCAND, V82, P152, DOI 10.1111/j.1600-0447.1990.tb01373.x Golding J, 2001, PAEDIATR PERINAT EP, V15, P74 Hultman CM, 2002, EPIDEMIOLOGY, V13, P417, DOI 10.1097/01.EDE.0000016968.14007.E6 Kolevzon A, 2006, AM J PSYCHIAT, V163, P1288, DOI 10.1176/appi.ajp.163.7.1288 KONSTANTAREAS MM, 1986, CHILD PSYCHIAT HUM D, V17, P53, DOI 10.1007/BF00707913 Landau EC, 1999, J AUTISM DEV DISORD, V29, P385, DOI 10.1023/A:1023030911527 Lee LC, 2008, PAEDIATR PERINAT EP, V22, P172, DOI 10.1111/j.1365-3016.2007.00919.x LIEDERMAN J, 1994, J CLIN EXP NEUROPSYC, V16, P754, DOI 10.1080/01688639408402689 MCNEIL TF, 1971, BRIT J PSYCHIAT, V118, P329, DOI 10.1192/bjp.118.544.329 MOURIDSEN SE, 1994, CHILD PSYCHIAT HUM D, V25, P31, DOI 10.1007/BF02251098 Stevens MC, 2000, J CLIN EXP NEUROPSYC, V22, P399, DOI 10.1076/1380-3395(200006)22:3;1-V;FT399 Torrey EF, 1997, SCHIZOPHR RES, V28, P1, DOI 10.1016/S0920-9964(97)00092-3 Williams E, 2008, DEV MED CHILD NEUROL, V50, P672, DOI 10.1111/j.1469-8749.2008.03042.x Yeates-Frederikx MHM, 2000, J AUTISM DEV DISORD, V30, P257, DOI 10.1023/A:1005500803764 NR 23 TC 11 Z9 11 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2010 VL 3 IS 4 BP 185 EP 190 DI 10.1002/aur.136 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 643RN UT WOS:000281316200005 PM 20803726 ER PT J AU Kaiser, MD Delmolino, L Tanaka, JW Shiffrar, M AF Kaiser, Martha D. Delmolino, Lara Tanaka, James W. Shiffrar, Maggie TI Comparison of Visual Sensitivity to Human and Object Motion in Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE autism; motion perception; biological motion; motion coherence ID POINT-LIGHT DISPLAYS; BIOLOGICAL MOTION; SOCIAL-PERCEPTION; RECOGNITION; CHILDREN; FMRI AB Successful social behavior requires the accurate detection of other people's movements. Consistent with this, typical observers demonstrate enhanced visual sensitivity to human movement relative to equally complex, nonhuman movement [e.g., Pinto & Shiffrar, 2009]. A psychophysical study investigated visual sensitivity to human motion relative to object motion in observers with autism spectrum disorder (ASD). Participants viewed point-light depictions of a moving person and, for comparison, a moving tractor and discriminated between coherent and scrambled versions of these stimuli in unmasked and masked displays. There were three groups of participants: young adults with ASD, typically developing young adults, and typically developing children. Across masking conditions, typical observers showed enhanced visual sensitivity to human movement while observers in the ASD group did not. Because the human body is an inherently social stimulus, this result is consistent with social brain theories [e.g., Pelphrey & Carter, 2008; Schultz, 2005] and suggests that the visual systems of individuals with ASD may not be tuned for the detection of socially relevant information such as the presence of another person. Reduced visual sensitivity to human movements could compromise important social behaviors including, for example, gesture comprehension. C1 [Kaiser, Martha D.] Yale Univ, Ctr Child Study, Child Neurosci Lab, Sch Med, New Haven, CT 06520 USA. [Kaiser, Martha D.; Shiffrar, Maggie] Rutgers State Univ, Dept Psychol, Newark, NJ 07102 USA. [Delmolino, Lara] Rutgers State Univ, Douglas Dev Disabil Ctr, New Brunswick, NJ 08903 USA. [Tanaka, James W.] Univ Victoria, Dept Psychol, Victoria, BC, Canada. RP Kaiser, MD (reprint author), Yale Univ, Ctr Child Study, Child Neurosci Lab, Sch Med, 230 S Frontage Rd, New Haven, CT 06520 USA. EM martha.kaiser@yale.edu FU Simons Foundation [94915]; National Sciences and Engineering Research Council of Canada; James S. McDonnell Foundation; Temporal Dynamics of Learning Center, NSF [SBE-0542013] FX Grant sponsor: Simons Foundation; Grant number: 94915; Grant sponsors: National Sciences and Engineering Research Council of Canada, James S. McDonnell Foundation; Temporal Dynamics of Learning Center; Grant number: SBE-0542013.This study was funded by grants from the Simons Foundation (#94915), National Sciences and Engineering Research Council of Canada, the James S. McDonnell Foundation, and the Temporal Dynamics of Learning Center (NSF Grant #SBE-0542013). The authors thank John Franchak for assistance with stimulus construction, Zena Fermano for assistance with data collection, and the staff at the Douglass Developmental Disabilities Center for their assistance with the autistic participants. CR American Psychiatric Association, 2006, DIAGN STAT MAN MENT Annaz D., 2010, DEV SCI Atkinson AP, 2009, NEUROPSYCHOLOGIA, V47, P3023, DOI 10.1016/j.neuropsychologia.2009.05.019 Beauchamp MS, 2003, J COGNITIVE NEUROSCI, V15, P991, DOI 10.1162/089892903770007380 Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001 BERTENTHAL BI, 1994, PSYCHOL SCI, V5, P221, DOI 10.1111/j.1467-9280.1994.tb00504.x Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434 Blake R, 2007, ANNU REV PSYCHOL, V58, P47, DOI 10.1146/annurev.psych.57.102904.190152 Chouchourelou A, 2006, SOC NEUROSCI, V1, P63, DOI 10.1080/17470910600630599 Creelman C. D., 1991, DETECTION THEORY USE Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018 Freitag CM, 2008, NEUROPSYCHOLOGIA, V46, P1480, DOI 10.1016/j.neuropsychologia.2007.12.025 Grossman ED, 2005, VISION RES, V45, P2847, DOI 10.1016/j.visres.2005.05.027 Herrington JD, 2007, RES AUTISM SPECT DIS, V1, P14, DOI 10.1016/j.rasd.2006.07.002 Hubert B, 2007, J AUTISM DEV DISORD, V37, P1386, DOI 10.1007/s10803-006-0275-y Jacobs A, 2004, J EXP PSYCHOL HUMAN, V30, P822, DOI 10.1037/0096-1523.30.5.822 JOHANSSO.G, 1973, PERCEPT PSYCHOPHYS, V14, P201, DOI 10.3758/BF03212378 KAISER MD, 2010, VISUAL PERCEPTION HU Kaiser MD, 2009, PSYCHON B REV, V16, P761, DOI 10.3758/PBR.16.5.761 Klin A, 2009, NATURE, V459, P257, DOI 10.1038/nature07868 Koldewyn K, 2010, BRAIN, V133, P599, DOI 10.1093/brain/awp272 Moore DG, 1997, BRIT J DEV PSYCHOL, V15, P401 Murphy P, 2009, NEUROPSYCHOLOGIA, V47, P3225, DOI 10.1016/j.neuropsychologia.2009.07.026 Parron C, 2008, AUTISM, V12, P261, DOI 10.1177/1362361307089520 Pelphrey KA, 2008, ANN NY ACAD SCI, V1145, P283, DOI 10.1196/annals.1416.007 Pinto J, 2009, SOC NEUROSCI, V4, P332, DOI 10.1080/17470910902826820 Saygin AP, 2007, BRAIN, V130, P2452, DOI 10.1093/brain/awm162 Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Simion F, 2008, P NATL ACAD SCI USA, V105, P809, DOI 10.1073/pnas.0707021105 Simmons DR, 2009, VISION RES, V49, P2705, DOI 10.1016/j.visres.2009.08.005 Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004 NR 31 TC 25 Z9 26 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2010 VL 3 IS 4 BP 191 EP 195 DI 10.1002/aur.137 PG 5 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 643RN UT WOS:000281316200006 PM 20533450 ER PT J AU Cook, EH AF Cook, Edwin H., Jr. TI Autism Spectrum Disorder: Unbroken Mirror Neurons; Rare Copy Number Variants SO AUTISM RESEARCH LA English DT Review C1 Univ Illinois, Inst Juvenile Res, Dept Psychiat, Chicago, IL 60608 USA. RP Cook, EH (reprint author), Univ Illinois, Inst Juvenile Res, Dept Psychiat, Chicago, IL 60608 USA. EM ecook@psych.uic.edu CR FAN YT, 2010, J CHILD PSYCHOL PSYC Pinto D, 2010, NATURE, V466, P368, DOI 10.1038/nature09146 NR 2 TC 1 Z9 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2010 VL 3 IS 4 BP 196 EP 197 DI 10.1002/aur.149 PG 2 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 643RN UT WOS:000281316200007 PM 20803727 ER PT J AU Bauminger, N Solomon, M Rogers, SJ AF Bauminger, Nirit Solomon, Marjorie Rogers, Sally J. TI Externalizing and Internalizing Behaviors in ASD SO AUTISM RESEARCH LA English DT Article DE psychopathology; adaptive behavior; high-functioning ASD; parental stress ID PERVASIVE DEVELOPMENTAL DISORDERS; SCHOOL-AGE-CHILDREN; ASPERGER-SYNDROME; CONSCIENCE DEVELOPMENT; PSYCHIATRIC-DISORDERS; ATTACHMENT SECURITY; PEER RELATIONSHIPS; AUTISTIC-CHILDREN; POSITIVE AFFECT; YOUNG-CHILDREN AB The current study investigated the relationships between internalizing and externalizing (I-E) behaviors and family variables, including both parenting stress and quality of attachment relations, in children aged 8-12 with high-functioning autism spectrum disorder (ASD) or with typical development. Compared to the group with typical development, children with ASD exhibited significantly greater levels of psychopathology as assessed by the Child Behavior Checklist [Achenbach, 1991], and parents of children with ASD exhibited higher parenting stress as assessed by the Parenting Stress Index [Abidin, 1995]. In a hierarchical multiple regression analysis, parenting stress emerged as the most important predictor of children's I-E problems. Results are discussed in light of the two groups' similar relationships between parenting stress and child psychopathology. C1 [Bauminger, Nirit] Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel. [Solomon, Marjorie; Rogers, Sally J.] UC Davis, Mind Inst, Dept Psychiat, Sacramento, CA USA. RP Bauminger, N (reprint author), Bar Ilan Univ, Sch Educ, IL-52900 Ramat Gan, Israel. EM bauminn@mail.biu.ac.il FU United States-Israel Binational Science Foundation (BSF) FX This study was supported by the United States-Israel Binational Science Foundation (BSF) to Drs. Rogers and Bauminger. CR Abidin RR, 1995, PARENTING STRESS IND Achenbach T, 2000, CHILD BEHAV CHECKLIS Achenbach TM, 1991, MANUAL CHILD BEHAV C American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th ARMSDEN GC, 1987, J YOUTH ADOLESCENCE, V16, P427, DOI 10.1007/BF02202939 Baker BL, 2005, J INTELL DISABIL RES, V49, P575, DOI 10.1111/j.1365-2788.2005.00691.x BAUMINGER N, 2009, PREDICTING FRI UNPUB Bauminger N, 2008, J ABNORM CHILD PSYCH, V36, P135, DOI 10.1007/s10802-007-9156-x Bolte S, 1999, PSYCHOPATHOLOGY, V32, P93, DOI 10.1159/000029072 BOUMA R, 1990, J CLIN PSYCHOL, V46, P722, DOI 10.1002/1097-4679(199011)46:6<722::AID-JCLP2270460605>3.0.CO;2-6 Bowlby J., 1973, ATTACHMENT LOSS Brereton AV, 2006, J AUTISM DEV DISORD, V36, P863, DOI 10.1007/s10803-006-0125-y Bretherton I., 1999, HDB ATTACHMENT THEOR, P89, DOI DOI 10.2307/1166187 BRISTOL MM, 1988, DEV PSYCHOL, V24, P441, DOI 10.1037/0012-1649.24.3.441 Bryson S. E., 2000, AUTISM, V4, P117, DOI DOI 10.1177/1362361300004002002 Burt KB, 2008, CHILD DEV, V79, P359, DOI 10.1111/j.1467-8624.2007.01130.x CAPPS L, 1994, DEV PSYCHOPATHOL, V6, P249, DOI 10.1017/S0954579400004569 CAPPS L, 1995, DEV PSYCHOPATHOL, V7, P137 CAPPS L, 1992, J CHILD PSYCHOL PSYC, V33, P1169, DOI 10.1111/j.1469-7610.1992.tb00936.x Deater-Deckard K, 2001, J CHILD PSYCHOL PSYC, V42, P565, DOI 10.1017/S0021963001007272 Deprey L., 2009, ASSESSMENT AUTISM SP, P290 DUARTE CS, 2005, AUTISM, V9, P415 Duarte CS, 2003, J AUTISM DEV DISORD, V33, P703, DOI 10.1023/B:JADD.0000006005.31818.1c Dumas J. E., 1991, EXCEPTIONALITY, V2, P97, DOI [10.1080/09362839109524770, DOI 10.1080/09362839109524770] Dunn L. M., 1997, EXAMINERS MANUAL PEA Forman EM, 2003, J CLIN CHILD ADOLESC, V32, P94, DOI 10.1207/S15374424JCCP3201_09 Frith U, 2004, J CHILD PSYCHOL PSYC, V45, P672, DOI 10.1111/j.1469-7610.2004.00262.x Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079 Ghaziuddin M, 1998, J INTELL DISABIL RES, V42, P279 Green J, 2000, J AUTISM DEV DISORD, V30, P279, DOI 10.1023/A:1005523232106 Grossmann K. E., 1999, HDB ATTACHMENT THEOR, P760 GROSSMANN KE, 1993, INT J ED RES, V19, P541 HARTER S, 1982, CHILD DEV, V53, P87, DOI 10.1111/j.1467-8624.1982.tb01295.x Hartley SL, 2008, J INTELL DISABIL RES, V52, P819, DOI 10.1111/j.1365-2788.2008.01065.x Hastings RP, 2002, AM J MENT RETARD, V107, P222, DOI 10.1352/0895-8017(2002)107<0222:BPOCWA>2.0.CO;2 Hay DF, 2004, J CHILD PSYCHOL PSYC, V45, P84, DOI 10.1046/j.0021-9630.2003.00308.x Holtmann M, 2007, PSYCHOPATHOLOGY, V40, P172, DOI 10.1159/000100007 Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021 Kerns KA, 1996, DEV PSYCHOL, V32, P457, DOI 10.1037/0012-1649.32.3.457 Kerns KA, 2001, J FAM PSYCHOL, V15, P69, DOI 10.1037//0893-3200.15.1.69 KIM JK, 2003, CHILD DEV, V74, P127 KOBAK RR, 1988, CHILD DEV, V59, P135, DOI 10.2307/1130395 Kochanska G, 2000, CHILD DEV, V71, P417, DOI 10.1111/1467-8624.00154 KOCHANSKA G, 1995, CHILD DEV, V66, P236, DOI 10.1111/j.1467-8624.1995.tb00868.x Laible DJ, 2000, CHILD DEV, V71, P1424, DOI 10.1111/1467-8624.00237 LAINHART JE, 1994, J AUTISM DEV DISORD, V24, P587, DOI 10.1007/BF02172140 Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 Maccoby E.E., 1983, HDB CHILD PSYCHOL, V4, P1 Macintosh KE, 2004, J CHILD PSYCHOL PSYC, V45, P421, DOI 10.1111/j.1469-7610.2004.00234.x Mesman J, 2001, J CHILD PSYCHOL PSYC, V42, P679, DOI 10.1017/S0021963001007351 Meyer JA, 2006, AUTISM, V10, P383, DOI 10.1177/1362361306064435 MOES D, 1992, PSYCHOL REP, V71, P1272, DOI 10.2466/PR0.71.8.1272-1274 Muris P., 2003, J CHILD FAM STUD, V12, P171, DOI [10.1023/A:1022858715598, DOI 10.1023/A:1022858715598] Petersen DJ, 2006, EUR CHILD ADOLES PSY, V15, P71, DOI 10.1007/s00787-006-0488-9 RODRIGUE JR, 1990, J CLIN CHILD PSYCHOL, V19, P371, DOI 10.1207/s15374424jccp1904_9 ROGERS S, 1991, J AM ACAD CILD ADOLE, V30, P433 ROGERS SJ, 1993, J AM ACAD CHILD PSY, V32, P1274, DOI 10.1097/00004583-199311000-00023 Rutgers AH, 2004, J CHILD PSYCHOL PSYC, V45, P1123, DOI 10.1111/j.1469-7610.2004.t01-1-00305.x Rutter M, 2009, J CHILD PSYCHOL PSYC, V50, P529, DOI 10.1111/j.1469-7610.2009.02042.x Sanders JL, 1997, CHILD FAM BEHAV THER, V19, P15, DOI 10.1300/J019v19n04_02 Sattler J. M., 1988, ASSESSMENT CHILDREN SHANY M, 2003, MAAKAV CURRENT MAPPI SHAPIRO T, 1987, J AM ACAD CHILD PSY, V26, P480, DOI 10.1097/00004583-198707000-00003 Sikora DM, 2008, J AUTISM DEV DISORD, V38, P440, DOI 10.1007/s10803-007-0407-z Siller M, 2002, J AUTISM DEV DISORD, V32, P77, DOI 10.1023/A:1014884404276 Sofronoff K, 2002, AUTISM, V6, P271, DOI 10.1177/1362361302006003005 SPANGLER G, 1993, CHILD DEV, V64, P1439, DOI 10.2307/1131544 Spangler G, 1998, INT J BEHAV DEV, V22, P681 Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013 Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9 Wilkinson G, 1993, WRAT 3 WIDE RANGE AC WOLF LC, 1989, J AUTISM DEV DISORD, V19, P157, DOI 10.1007/BF02212727 Zimmermann P., 1997, DEV INTERACTION ATTA, P271 NR 74 TC 15 Z9 15 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2010 VL 3 IS 3 BP 101 EP 112 DI 10.1002/aur.131 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 620NV UT WOS:000279507500001 PM 20575109 ER PT J AU Mitchell, P Mottron, L Soulieres, I Ropar, D AF Mitchell, Peter Mottron, Laurent Soulieres, Isabelle Ropar, Danielle TI Susceptibility to the Shepard Illusion in Participants with Autism: Reduced Top-Down Influences Within Perception? SO AUTISM RESEARCH LA English DT Article DE low-level perception; visual illusion; 3D perception ID PRIOR KNOWLEDGE; LOCAL BIAS; INDIVIDUALS; CHILDREN; PERFORMANCE; ABILITIES; DEFICIT; TASKS AB Previous research [Ropar & Mitchell, 2002] has shown that autistic individuals are somewhat immune to biases induced by top-down processes, particularly the influence of previous knowledge on perception. In order to test this hypothesis within perception, 18 participants with autism who had measured intelligence in the normal range were compared against 18 matched controls in their susceptibility to the Shepard illusion. The illusion consists in misperceiving the shape of a parallelogram in the presence of depth cues. It is attributed [Mitchell, Ropar, Ackroyd, & Rajendran, 2005] to the effect of top-down constraints within perception. The task involved adjusting a stimulus to the dimensions of a template on a computer screen. Both groups were susceptible to the illusion and the illusion effect was stronger when three-dimensional perspective cues were prominent. Notably, participants with autism were less susceptible to the illusion than typically developing individuals. The findings raise the possibility that in some instances top-down influences are attenuated in individuals with autism. C1 [Mitchell, Peter; Ropar, Danielle] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England. [Mottron, Laurent; Soulieres, Isabelle] CETEDUM, Montreal, PQ, Canada. [Mottron, Laurent; Soulieres, Isabelle] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada. RP Mitchell, P (reprint author), Univ Nottingham, Sch Psychol, Univ Pk, Nottingham NG7 2RD, England. EM peter.mitchell@nottingham.edu.my FU Canadian Institutes for Health Research [MOP-84243] FX Grant sponsor: Canadian Institutes for Health Research; Grant number: MOP-84243. CR Bolte S, 2007, J AUTISM DEV DISORD, V37, P1493, DOI 10.1007/s10803-006-0231-x Brosnan MJ, 2004, J CHILD PSYCHOL PSYC, V45, P459, DOI 10.1111/j.1469-7610.2004.00237.x Bruce V., 1996, VISUAL PERCEPTION PH Cohen DJ, 1997, J EXP PSYCHOL HUMAN, V23, P609, DOI 10.1037/0096-1523.23.3.609 Cohen J., 1988, STAT POWER ANAL BEHA, V2nd DOHERTY M, 2010, DEV SCI Drake JE, 2009, PHILOS T R SOC B, V364, P1449, DOI 10.1098/rstb.2008.0295 Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Mitchell P, 2005, J EXP PSYCHOL HUMAN, V31, P996, DOI 10.1037/0096-1523.31.5.996 Mitchell P, 2004, INFANT CHILD DEV, V13, P185, DOI 10.1002/icd.348 Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P743, DOI 10.1017/S0021963098003795 Mottron L, 2006, J AUTISM DEV DISORD, V36, P27, DOI 10.1007/s10803-005-0040-7 MOTTRON L, 1995, PSYCHOL MED, V25, P639 O'Riordan MA, 2001, J EXP PSYCHOL HUMAN, V27, P719, DOI 10.1037//0096-1523.27.3.719 Ropar D, 2001, J CHILD PSYCHOL PSYC, V42, P539, DOI 10.1111/1469-7610.00748 Ropar D, 1999, J CHILD PSYCHOL PSYC, V40, P1283, DOI 10.1017/S0021963099004667 Ropar D, 2002, J CHILD PSYCHOL PSYC, V43, P647, DOI 10.1111/1469-7610.00053 Ropar D, 2001, DEVELOPMENTAL SCI, V4, P433, DOI 10.1111/1467-7687.00185 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x Sheppard E, 2007, J AUTISM DEV DISORD, V37, P1913, DOI 10.1007/s10803-006-0321-9 Soulieres I, 2007, J AUTISM DEV DISORD, V37, P481, DOI 10.1007/s10803-006-0172-4 SOULIERES S, 2009, HUM BRAIN MAPP, V30, P4082 Wang LX, 2007, COGN NEUROPSYCHOL, V24, P550, DOI 10.1080/13546800701417096 Yirmiya N, 1996, CHILD DEV, V67, P2045, DOI 10.1111/j.1467-8624.1996.tb01842.x NR 27 TC 14 Z9 14 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2010 VL 3 IS 3 BP 113 EP 119 DI 10.1002/aur.130 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 620NV UT WOS:000279507500002 PM 20575110 ER PT J AU Mazefsky, CA Conner, CM Oswald, DP AF Mazefsky, Carla A. Conner, Caitlin M. Oswald, Donald P. TI Association Between Depression and Anxiety in High-Functioning Children with Autism Spectrum Disorders and Maternal Mood Symptoms SO AUTISM RESEARCH LA English DT Article DE autism; Asperger's disorder; psychiatric comorbidity; anxiety; depression; mood disorders; familial aggregation; maternal symptoms ID PERVASIVE DEVELOPMENTAL DISORDERS; PSYCHIATRIC-DISORDERS; FAMILY-HISTORY; GENETIC EPIDEMIOLOGY; ASPERGER-SYNDROME; INDIVIDUALS; SCL-90-R; ADULTS; METAANALYSIS; INTERVIEW AB Research suggests that children with autism spectrum disorders (ASDs) and their relatives have high rates of depression and anxiety. However, relatively few studies have looked at both factors concurrently. This study examined the potential relationship between maternal mood symptoms and depression and anxiety in their children with ASD. Participants were 31 10- to 17-year-old children with an ASD diagnosis that was supported by gold-standard measures and their biological mothers. Mothers completed the Autism Comorbidity Interview to determine whether the child with ASD met criteria for any depressive or anxiety diagnoses and a questionnaire of their own current mood symptoms. As expected, many children with ASD met criteria for lifetime diagnoses of depressive (32%) and anxiety disorders (39%). Mothers' report of their own current mood symptoms revealed averages within the normal range, though there was significant variability. Approximately 75% of children with ASD could be correctly classified as having a depressive or anxiety disorder history or not based on maternal symptoms of interpersonal sensitivity, hostility, phobic anxiety, depression, and anxiety. The results provide preliminary evidence that maternal mood symptoms may be related to depression and anxiety in their children with ASD. Although the design did not allow for testing of heritability per se, the familial transmission patterns were generally consistent with research in typical populations. While larger follow-up studies are needed, this research has implications for prevention and intervention efforts. C1 [Mazefsky, Carla A.; Conner, Caitlin M.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA. [Oswald, Donald P.] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA USA. RP Mazefsky, CA (reprint author), Univ Pittsburgh, Dept Psychiat, Webster Hall Suite 300,3811 OHara St, Pittsburgh, PA 15213 USA. EM mazefskyca@upmc.edu FU Organization for Autism Research FX Grant sponsor: Organization for Autism Research. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004 CARMODY TP, 1989, J CLIN PSYCHOL, V45, P754, DOI 10.1002/1097-4679(198909)45:5<754::AID-JCLP2270450510>3.0.CO;2-C CARPENTER KM, 1995, J CLIN PSYCHOL, V51, P383, DOI 10.1002/1097-4679(199505)51:3<383::AID-JCLP2270510310>3.0.CO;2-Q DeLong R, 2004, J NEUROPSYCH CLIN N, V16, P199, DOI 10.1176/appi.neuropsych.16.2.199 Derogatis L. R., 1994, SYMPTOM CHECKLIST 90 Ghaziuddin M, 2005, J AUTISM DEV DISORD, V35, P177, DOI 10.1007/s10803-005-1996-z Ghaziuddin M, 2002, J AUTISM DEV DISORD, V32, P299, DOI 10.1023/A:1016330802348 Ghaziuddin M, 1998, J AUTISM DEV DISORD, V28, P111, DOI 10.1023/A:1026036514719 Kendler KS, 2001, ARCH GEN PSYCHIAT, V58, P1005, DOI 10.1001/archpsyc.58.11.1005 Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593 Lainhart JE, 1999, INT REV PSYCHIATR, V11, P278, DOI 10.1080/09540269974177 Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Mazefsky CA, 2008, J ABNORM CHILD PSYCH, V36, P591, DOI 10.1007/s10802-007-9202-8 Mazefsky CA, 2011, RES AUTISM SPECT DIS, V5, P164, DOI 10.1016/j.rasd.2010.03.006 Mazefsky CA, 2008, AUTISM RES, V1, P193, DOI 10.1002/aur.23 Middeldorp CM, 2005, PSYCHOL MED, V35, P611, DOI 10.1017/S003329170400412X Murphy M, 2000, PSYCHOL MED, V30, P1411, DOI 10.1017/S0033291799002949 Nes RB, 2007, TWIN RES HUM GENET, V10, P450, DOI 10.1375/twin.10.3.450 Piven J, 1999, AM J PSYCHIAT, V156, P557 PIVEN J, 1991, J AM ACAD CHILD PSY, V30, P471, DOI 10.1097/00004583-199105000-00019 Rauter UK, 1996, J CLIN PSYCHOL, V52, P625 Schmitz N, 2000, QUAL LIFE RES, V9, P185, DOI 10.1023/A:1008931926181 Singer GHS, 2006, AM J MENT RETARD, V111, P155, DOI 10.1352/0895-8017(2006)111[155:MOCSOD]2.0.CO;2 Spitzer R. L., 1978, SCHEDULE AFFECTIVE D Sterling L, 2008, J AUTISM DEV DISORD, V38, P1011, DOI 10.1007/s10803-007-0477-y Stewart ME, 2006, AUTISM, V10, P103, DOI 10.1177/1362361306062013 Sullivan PF, 2000, AM J PSYCHIAT, V157, P1552, DOI 10.1176/appi.ajp.157.10.1552 TAMBS K, 1991, J AFFECT DISORDERS, V21, P117, DOI 10.1016/0165-0327(91)90058-Z TSANKANIKOS E, 2006, J AUTISM DEV DISORD, V36, P1123 Weschler D., 1999, WECHSLER ABBREVIATED White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003 NR 34 TC 23 Z9 24 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2010 VL 3 IS 3 BP 120 EP 127 DI 10.1002/aur.133 PG 8 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 620NV UT WOS:000279507500003 PM 20578069 ER PT J AU Falter, CM Grant, KCP Davis, G AF Falter, Christine M. Grant, Kate C. Plaisted Davis, Greg TI Object-Based Attention Benefits Reveal Selective Abnormalities of Visual Integration in Autism SO AUTISM RESEARCH LA English DT Article DE autism; Gestalt; grouping; top-down ID GLOBAL PRECEDENCE; LOCAL PRECEDENCE; CHILDREN; INDIVIDUALS; PERCEPTION; DISORDERS; TASK AB A pervasive integration deficit could provide a powerful and elegant account of cognitive processing in autism spectrum disorders (ASD). However, in the case of visual Gestalt grouping, typically assessed by tasks that require participants explicitly to introspect on their own grouping perception, clear evidence for such a deficit remains elusive. To resolve this issue, we adopt an index of Gestalt grouping from the object-based attention literature that does not require participants to assess their own grouping perception. Children with ASD and mental- and chronological-age matched typically developing children (TD) performed speeded orientation discriminations of two diagonal lines. The lines were superimposed on circles that were either grouped together or segmented on the basis of color, proximity or these two dimensions in competition. The magnitude of performance benefits evident for grouped circles, relative to ungrouped circles, provided an index of grouping under various conditions. Children with ASD showed comparable grouping by proximity to the TO group, but reduced grouping by similarity. ASD seems characterized by a selective bias away from grouping by similarity combined with typical levels of grouping by proximity, rather than by a pervasive integration deficit. C1 [Falter, Christine M.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England. [Grant, Kate C. Plaisted; Davis, Greg] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England. RP Falter, CM (reprint author), Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England. EM christine.falter@psych.ox.ac.uk; gjd1000@cam.ac.uk RI Davis, Gregory/G-9954-2012 FU German National Academic Foundation FX Grant sponsor: German National Academic Foundation. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Ashwin E, 2009, BIOL PSYCHIAT, V65, P17, DOI 10.1016/j.biopsych.2008.06.012 BOELTE S, 2007, J AUTISM DEV DISORD, V37, P1493 Brosnan MJ, 2004, J CHILD PSYCHOL PSYC, V45, P459, DOI 10.1111/j.1469-7610.2004.00237.x COHEN J, 1993, BEHAV RES METH INSTR, V25, P257, DOI 10.3758/BF03204507 Driver J, 2001, COGNITION, V80, P61, DOI 10.1016/S0010-0277(00)00151-7 DUNCAN J, 1984, J EXP PSYCHOL GEN, V113, P501, DOI 10.1037/0096-3445.113.4.501 Falter CM, 2008, J AUTISM DEV DISORD, V38, P507, DOI 10.1007/s10803-007-0419-8 Feldman J, 2007, PERCEPT PSYCHOPHYS, V69, P816, DOI 10.3758/BF03193781 Frith C, 2004, LANCET NEUROL, V3, P577, DOI 10.1016/S1474-4422(04)00875-0 Frith U., 1989, AUTISM EXPLAINING EN Gopnik A, 2001, DEV PSYCHOL, V37, P620, DOI 10.1037//0012-1649.37.5.620 Greenaway R, 2005, PSYCHOL SCI, V16, P987, DOI 10.1111/j.1467-9280.2005.01648.x Han SH, 2004, NEUROSCI LETT, V367, P40, DOI 10.1016/j.neulet.2004.05.098 Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x Koffka K., 1935, PRINCIPLES GESTALT P LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P203, DOI 10.1017/S0021963098003333 NAVON D, 1981, PSYCHOL RES-PSYCH FO, V43, P1, DOI 10.1007/BF00309635 Plaisted K, 1998, J CHILD PSYCHOL PSYC, V39, P777, DOI 10.1017/S0021963098002613 Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489 Plaisted KC, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P149 POMERANTZ JR, 1983, J EXP PSYCHOL GEN, V112, P516, DOI 10.1037/0096-3445.112.4.516 Raven J. C., 1958, STANDARD PROGRESSIVE Ropar D, 1999, J CHILD PSYCHOL PSYC, V40, P1283, DOI 10.1017/S0021963099004667 SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x Wagemans J, 1997, TRENDS COGN SCI, V1, P346, DOI 10.1016/S1364-6613(97)01105-4 Wechsler D, 1981, WECHSLER ADULT INTEL WITKIN HA, 1971, MANUAL EMBEDDED FIGS NR 30 TC 9 Z9 9 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2010 VL 3 IS 3 BP 128 EP 136 DI 10.1002/aur.134 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 620NV UT WOS:000279507500004 PM 20578070 ER PT J AU McBride, KL Varga, EA Pastore, MT Prior, TW Manickam, K Atkin, JF Herman, GE AF McBride, Kim L. Varga, Elizabeth A. Pastore, Matthew T. Prior, Thomas W. Manickam, Kandamurugu Atkin, Joan F. Herman, Gail E. TI Confirmation Study of PTEN Mutations Among Individuals with Autism or Developmental Delays/Mental Retardation and Macrocephaly SO AUTISM RESEARCH LA English DT Article DE genetic; Cowden syndrome; molecular genetics; PTEN; cancer; autism; developmental delay ID RILEY-RUVALCABA-SYNDROME; SPECTRUM DISORDERS; TUMOR-SUPPRESSOR; COWDEN-SYNDROME; PREVALENCE; GENETICS; PHOSPHATASE; PROTEIN; FAMILY AB There is a strong genetic component to autism spectrum disorders (ASD), but due to significant genetic heterogeneity, individual genetic abnormalities contribute a small percentage to the overall total. Previous studies have demonstrated PTEN mutations in a sizable proportion of individuals with ASD or mental retardation/developmental delays (MR/DD) and macrocephaly that do not have features of Cowden or Bannayan-Riley-Ruvalcaba syndrome. This study was performed to confirm our previous results. We reviewed the charts of individuals who had PTEN clinical sequencing performed at our institution from January 2008 to July 2009. There were 93 subjects tested from our institution during that period. PTEN mutations were found in 2/39 (5.1%) ASD patients and 2/51 (3.9%) MR/DD patients. Three additional patients without mutations had no diagnostic information. Multiple relatives of individuals with a PTEN mutation had macrocephaly, MR, or early onset cancer (breast, renal, and prostate). Of those relatives tested, all had the familial PTEN mutation. None of the affected relatives had previously been diagnosed with Cowden or Bannayan-Riley-Ruvalcaba syndrome. We noted in our previous study several adult relatives without any findings who puled a mutation. Combined with data from our previous cohort, we have found PTEN mutations in 7/99 (7.1%) of individuals with ASD and 8/100 (8.0%) of individuals with MR/DD, all of whom had macrocephaly. We recommend testing for mutations in PTEN for individuals with ASD or MR/DD and macrocephaly. If mutations are found, other family Members should be offered testing and the adults offered cancer screening if they have a PTEN mutation. C1 [McBride, Kim L.; Varga, Elizabeth A.; Herman, Gail E.] Nationwide Childrens Hosp, Res Inst, Ctr Mol & Human Genet, Columbus, OH 43205 USA. [McBride, Kim L.; Varga, Elizabeth A.; Pastore, Matthew T.; Manickam, Kandamurugu; Atkin, Joan F.; Herman, Gail E.] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43210 USA. [Prior, Thomas W.] Ohio State Univ, Coll Med, Dept Pathol, Columbus, OH 43210 USA. RP McBride, KL (reprint author), Nationwide Childrens Hosp, Res Inst, Ctr Mol & Human Genet, 700 Childrens Dr, Columbus, OH 43205 USA. EM Kim.McBride@NationwideChildrens.org RI Pastore, Matthew/B-6867-2012; Manickam, Kandamurugu/E-3585-2011; McBride, Kim/A-5879-2008 OI McBride, Kim/0000-0002-8407-8942 CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Amir RE, 1999, NAT GENET, V23, P185 Baker P, 1998, J AUTISM DEV DISORD, V28, P279, DOI 10.1023/A:1026004501631 Butler MG, 2005, J MED GENET, V42, P318, DOI 10.1136/jmg.2004.024646 Buxbaum JD, 2007, AM J MED GENET B, V144B, P484, DOI 10.1002/ajmg.b.30493 Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458 DALY MB, 2009, NCCN CLIN PRACTICE O Goffin A, 2001, AM J MED GENET, V105, P521, DOI 10.1002/ajmg.1477 Han SY, 2000, CANCER RES, V60, P3147 Hatton DD, 2006, AM J MED GENET A, V140A, P1804, DOI 10.1002/ajmg.a.31286 Herman GE, 2007, AM J MED GENET A, V143A, P589, DOI 10.1002/ajmg.a.31619 Herman GE, 2007, GENET MED, V9, P268, DOI 10.1097/GIM.0b013e31804d683b Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465 Maehama T, 2001, ANNU REV BIOCHEM, V70, P247, DOI 10.1146/annurev.biochem.70.1.247 Maehama T, 1999, TRENDS CELL BIOL, V9, P125, DOI 10.1016/S0962-8924(99)01519-6 Muhle R., 2004, PEDIATRICS, V113, P472 Ng PC, 2003, NUCLEIC ACIDS RES, V31, P3812, DOI 10.1093/nar/gkg509 Orloff MS, 2008, ONCOGENE, V27, P5387, DOI 10.1038/onc.2008.237 O'Roak BJ, 2008, AUTISM RES, V1, P4, DOI 10.1002/aur.3 Parisi MA, 2001, J MED GENET, V38, P52, DOI 10.1136/jmg.38.1.52 Schaefer GB, 2008, GENET MED, V10, P301, DOI 10.1097/GIM.0b013e31816b5cc9 Sunyaev S, 2001, HUM MOL GENET, V10, P591, DOI 10.1093/hmg/10.6.591 Varga EA, 2009, GENET MED, V11, P111, DOI 10.1097/GIM.0b013e31818fd762 Zhou XP, 2003, AM J HUM GENET, V73, P404, DOI 10.1086/377109 Zori RT, 1998, AM J MED GENET, V80, P399, DOI 10.1002/(SICI)1096-8628(19981204)80:4<399::AID-AJMG18>3.0.CO;2-O NR 25 TC 58 Z9 58 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2010 VL 3 IS 3 BP 137 EP 141 DI 10.1002/aur.132 PG 5 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 620NV UT WOS:000279507500005 PM 20533527 ER PT J AU Cook, EH AF Cook, Edwin H., Jr. TI Clinical Genetic Microarray Testing; ASD Neuropathology SO AUTISM RESEARCH LA English DT Review ID AUTISM SPECTRUM DISORDERS C1 Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA. RP Cook, EH (reprint author), Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA. EM ecook@psych.uic.edu CR Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Johnson CP, 2007, PEDIATRICS, V120, P1183, DOI 10.1542/peds.2007-2361 Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 Shen YP, 2010, PEDIATRICS, V125, pE727, DOI 10.1542/peds.2009-1684 Strauss KA, 2006, NEW ENGL J MED, V354, P1370, DOI 10.1056/NEJMoa052773 WEGIEL J, ACTA NEUROPATHOLOGY NR 6 TC 0 Z9 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2010 VL 3 IS 3 BP 142 EP 143 DI 10.1002/aur.140 PG 2 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 620NV UT WOS:000279507500006 ER PT J AU Allen-Brady, K Cannon, D Robison, R McMahon, WM Coon, H AF Allen-Brady, Kristina Cannon, Dale Robison, Reid McMahon, William M. Coon, Hilary TI Unified Theory of Autism Revisited: Linkage Evidence Points to Chromosome X using a High-Risk Subset of AGRE Families SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; genetic linkage; dominant model; pedigree structure; chromosome Xp ID LINKED MENTAL-RETARDATION; NEURONAL CALCIUM SENSOR-1; IL1RAPL1 GENE; UTAH PEDIGREES; LOD SCORES; HETEROGENEITY; DISSECTION; DISORDERS; MUTATION; LOCI AB Zhao et al. [2007] in their "Unified Theory of Autism" hypothesized that incidence of autism in males could be explained by essentially two types of family structures: majority of autism cases are from low-risk autism families with de novo mutations, and a minority of cases are from high-risk multiplex families, where risk to male offspring approximates 50% consistent with a dominant model and high penetrance. Using the Autism Genetic Resource Exchange (AGRE) data set, Zhao et al. identified 86 high-risk families with likely dominant transmission. As genotype data are now available for many members of the AGRE resource, the objective of this manuscript was to determine if dominant linkage evidence for an autism predisposition gene exists in these 86 high-risk families. HumanHap550K Illumina SNP data were available for 92% of 455 total family members in these 86 high-risk families. We performed a linkage analysis using a pruned subset of markers where markers in high linkage disequilibrium were removed. We observed a single suggestive peak (maximum LOD 2.01, maximum HLOD 2.08) under a dominant model on chromosome Xp22.11-p21.2 that encompasses the 1L1RAPL1 gene. Mutations or deletions in 1L1RAPL1 have been previously reported in three families with autism. In our study, 11 families contributed nominally (P<0.05, HLOD > 0.588) to the chromosome X peak. These results demonstrate that identification of a more homogeneous subset of autism cases, which was based on family structure in this study, may help to identify, localize and further our understanding of autism predisposition genes. C1 [Allen-Brady, Kristina; Cannon, Dale; Robison, Reid; McMahon, William M.; Coon, Hilary] Univ Utah, Dept Psychiat, Utah Autism Res Project, Salt Lake City, UT 84108 USA. [McMahon, William M.; Coon, Hilary] Univ Utah, Inst Brain, Salt Lake City, UT 84108 USA. RP Allen-Brady, K (reprint author), Univ Utah, Dept Psychiat, Utah Autism Res Project, 650 Komas Dr,Suite 206, Salt Lake City, UT 84108 USA. EM Kristina.allen@utah.edu FU [R01 MH069359] FX We thank Jim Farnham for his assistance with generation of the linkage subset of markers. This work was supported by R01 MH069359. We gratefully acknowledge the resources provided by the Autism Genetic Resource Exchange (AGRE) Consortium* and the participating AGRE families. The Autism Genetic Resource Exchange is a program of Autism Speaks and is supported, in part, by grant 1U24MH081810 from the National Institute of Mental Health to Clara M. Lajonchere (PI). CR Abecasis GR, 2002, NAT GENET, V30, P97, DOI 10.1038/ng786 Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Abreu PC, 2002, GENET EPIDEMIOL, V22, P156, DOI 10.1002/gepi.0155 Abreu PC, 1999, AM J HUM GENET, V65, P847, DOI 10.1086/302536 Allen-Brady K, 2009, MOL PSYCHIATR, V14, P590, DOI 10.1038/mp.2008.14 Allen-Brady Kristina, 2007, BMC Proc, V1 Suppl 1, pS160 Allen-Brady K, 2009, AM J HUM GENET, V84, P678, DOI 10.1016/j.ajhg.2009.04.002 Bhat SS, 2008, CLIN GENET, V73, P94, DOI 10.1111/j.1399-0004.2007.00920.x Camp NJ, 2005, PROSTATE, V65, P365, DOI 10.1002/pros.20287 Camp NJ, 2005, AM J MED GENET B, V135B, P85, DOI 10.1002/ajmg.b.30177 Carrie A, 1999, NAT GENET, V23, P25 Cho Kelly, 2007, BMC Proc, V1 Suppl 1, pS161 Duffy DL, 2006, BEHAV GENET, V36, P4, DOI 10.1007/s10519-005-9015-x Geschwind DH, 2001, AM J HUM GENET, V69, P463, DOI 10.1086/321292 GOLDIN LR, 1992, GENET EPIDEMIOL, V9, P61, DOI 10.1002/gepi.1370090107 Gomez M, 2001, NEURON, V30, P241, DOI 10.1016/S0896-6273(01)00276-8 Jin H, 2000, EUR J HUM GENET, V8, P87, DOI 10.1038/sj.ejhg.5200415 LANDER E, 1995, NAT GENET, V11, P241, DOI 10.1038/ng1195-241 Lepretre F, 2003, CYTOGENET GENOME RES, V101, P124, DOI 10.1159/000074167\ LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Martone ME, 1999, CELL TISSUE RES, V295, P395, DOI 10.1007/s004410051246 Nawara M, 2008, AM J MED GENET A, V146A, P3167, DOI 10.1002/ajmg.a.32613 Ott J., 1999, ANAL HUMAN GENETIC L Piton A, 2008, HUM MOL GENET, V17, P3965, DOI 10.1093/hmg/ddn300 Tabolacci E, 2006, AM J MED GENET A, V140A, P482, DOI 10.1002/ajmg.a.31107 Thomas A, 2000, STAT COMPUT, V10, P259, DOI 10.1023/A:1008947712763 Tsujimoto T, 2002, SCIENCE, V295, P2276, DOI 10.1126/science.1068278 Zhao X, 2007, P NATL ACAD SCI USA, V104, P12831, DOI 10.1073/pnas.0705803104 NR 28 TC 6 Z9 6 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2010 VL 3 IS 2 BP 47 EP 52 DI 10.1002/aur.119 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 590ED UT WOS:000277206100001 PM 20437600 ER PT J AU Scott-Van Zeeland, AA Dapretto, M Ghahremani, DG Poldrack, RA Bookheimer, SY AF Scott-Van Zeeland, Ashley A. Dapretto, Mirella Ghahremani, Dara G. Poldrack, Russell A. Bookheimer, Susan Y. TI Reward Processing in Autism SO AUTISM RESEARCH LA English DT Article DE functional MRI (fMRI); social cognition; reward; learning ID SOCIAL COGNITION; ORBITOFRONTAL CORTEX; DIAGNOSTIC INTERVIEW; REPETITIVE BEHAVIORS; BASAL GANGLIA; FMRI; OXYTOCIN; BRAIN; SCHIZOPHRENIA; PREDICTION AB The social motivation hypothesis of autism posits that infants with autism do not experience social stimuli as rewarding, thereby leading to a cascade of potentially negative consequences for later development. While possible downstream effects of this hypothesis such as altered face and voice processing have been examined, there has not been a direct investigation of social reward processing in autism. Here we use functional magnetic resonance imaging to examine social and monetary rewarded implicit learning in children with and without autism spectrum disorders (ASD). Sixteen males with ASD and sixteen age- and IQ-matched typically developing (TO) males were scanned while performing two versions of a rewarded implicit learning task. In addition to examining responses to reward, we investigated the neural circuitry supporting rewarded learning and the relationship between these factors and social development. We found diminished neural responses to both social and monetary rewards in ASD, with a pronounced reduction in response to social rewards (SR). Children with ASD also demonstrated a further deficit in frontostriatal response during social, but not monetary, rewarded learning. Moreover, we show a relationship between ventral striatum activity and social reciprocity in TD children. Together, these data support the hypothesis that children with ASD have diminished neural responses to SR, and that this deficit relates to social learning impairments. C1 [Scott-Van Zeeland, Ashley A.; Poldrack, Russell A.; Bookheimer, Susan Y.] Univ Calif Los Angeles, Ctr Cognit Neurosci, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA. [Dapretto, Mirella; Ghahremani, Dara G.; Poldrack, Russell A.; Bookheimer, Susan Y.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA. [Dapretto, Mirella; Poldrack, Russell A.; Bookheimer, Susan Y.] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA. [Poldrack, Russell A.; Bookheimer, Susan Y.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA. [Scott-Van Zeeland, Ashley A.] Univ Calif Los Angeles, Neurosci Interdept Program, Los Angeles, CA USA. [Scott-Van Zeeland, Ashley A.] Scripps Translat Sci Inst, La Jolla, CA USA. [Poldrack, Russell A.] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA. RP Bookheimer, SY (reprint author), Semel Inst Psychiat & Biobehav Sci, 760 Westwood Plaza,C8-881, Los Angeles, CA 90095 USA. EM sbook@ucla.edu FU NICHD [P01 HD035470]; NIH/NICHO IPSO [HD0557841, R01 HD065280-01, UL1 12R025774] FX This work was in part supported by grants from the NICHD (P01 HD035470 and NIH/NICHO IPSO HD055784; 1R01 HD065280-01; UL1 12R025774), the National Alliance for Autism Research, Autism Speaks, Whitehall Foundation, as well as by the Training Program in Neurobehavioral Genetics (T32 MH073526), and a NRSA predoctoral fellowship (F31 MH079645) and Dickinson Fellowship to Ashley Scott-Van Zeeland. The authors wish to thank J. Cohen for her technical assistance. For generous support the authors also wish to thank the Brain Mapping Medical Research Organization, Brain Mapping Support Foundation, PiersonLovelace Foundation, Ahmanson Foundation, William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation, Tamkin Foundation, Jennifer Jones-Simon Foundation, Capital Group Companies Charitable Foundation, Robson Family and Northstar Fund. The project described was in part also supported by grants (121212169, RR13642 and RI200865) from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NTH); its contents are solely the responsibility of the authors and do not necessarily represent the official views of NCR or NWT. CR Bartels A, 2004, NEUROIMAGE, V21, P1155, DOI 10.1016/j.neuroimage.2003.11.003 Bray S, 2007, J NEUROPHYSIOL, V97, P3036, DOI 10.1152/jn.01211.2006 Constantino JN, 2003, J AUTISM DEV DISORD, V33, P427, DOI 10.1023/A:1025014929212 Dawson G, 2005, DEV NEUROPSYCHOL, V27, P403, DOI 10.1207/s15326942dn2703_6 Dawson G, 2004, DEV PSYCHOL, V40, P271, DOI 10.1037/0012-1649.40.2.271 Dawson G, 1998, J AUTISM DEV DISORD, V28, P479, DOI 10.1023/A:1026043926488 de Araujo IET, 2003, J NEUROPHYSIOL, V90, P1865, DOI 10.1152/jn.00297.2003 Febo M, 2005, J NEUROSCI, V25, P11637, DOI 10.1523/JNEUROSCI.3604-05.2005 FORMAN SD, 1995, MAGNET RESON MED, V33, P636, DOI 10.1002/mrm.1910330508 Frith CD, 2008, PHILOS T R SOC B, V363, P2033, DOI 10.1098/rstb.2008.0005 Galvan A, 2006, J NEUROSCI, V26, P6885, DOI 10.1523/JNEUROSCI.1062-06.2006 Grelotti DJ, 2002, DEV PSYCHOBIOL, V40, P213, DOI 10.1002/dev.10028 Hare TA, 2008, J NEUROSCI, V28, P5623, DOI 10.1523/JNEUROSCI.1309-08.2008 Haznedar MM, 2006, AM J PSYCHIAT, V163, P1252, DOI 10.1176/appi.ajp.163.7.1252 Hollander E, 2005, BIOL PSYCHIAT, V58, P226, DOI 10.1016/j.biopsych.2005.03.040 Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021 Hollander E, 2007, BIOL PSYCHIAT, V61, P498, DOI 10.1016/j.bipsych.2006.05.030 Izuma K, 2008, NEURON, V58, P284, DOI 10.1016/j.neuron.2008.03.020 Jenkinson M, 2002, NEUROIMAGE, V17, P825, DOI 10.1006/nimg.2002.1132 Kates WR, 1998, ANN NEUROL, V43, P782, DOI 10.1002/ana.410430613 Kirsch P, 2005, J NEUROSCI, V25, P11489, DOI 10.1523/JNEUROSCI.3984-05.2005 KLIN A, 1991, J AUTISM DEV DISORD, V21, P29, DOI 10.1007/BF02206995 Knowlton B J, 1994, Learn Mem, V1, P106 Knutson B, 2005, CURR OPIN NEUROL, V18, P411, DOI 10.1097/01.wco.0000173463.24758.f6 Kuhl P. K., 2005, DEVELOPMENTAL SCI, V8, P1, DOI [DOI 10.1111/J.1467-7687.2004.00384.X, 10.1111/j.1467-7687.2004.00384.x] Langen M, 2007, BIOL PSYCHIAT, V62, P262, DOI 10.1016/j.biopsych.2006.09.040 Legerstee M, 1998, CHILD DEV, V69, P37, DOI 10.2307/1132068 Lencz T, 2000, BIOL PSYCHIAT, V47, p99S, DOI 10.1016/S0006-3223(00)00594-1 LEVY F, 1995, BRAIN RES, V669, P197, DOI 10.1016/0006-8993(94)01236-B LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Mostofsky SH, 2000, J INT NEUROPSYCH SOC, V6, P752, DOI 10.1017/S1355617700677020 O'Doherty J, 2001, NAT NEUROSCI, V4, P95 O'Doherty JP, 2002, NEURON, V33, P815, DOI 10.1016/S0896-6273(02)00603-7 Olsson A, 2004, PSYCHOL SCI, V15, P822, DOI 10.1111/j.0956-7976.2004.00762.x Pavlov I., 1927, CONDITIONED REFLEXES Pelphrey K, 2004, MENT RETARD DEV D R, V10, P259, DOI 10.1002/mrdd Phillips ML, 1998, PSYCHIAT RES-NEUROIM, V83, P127, DOI 10.1016/S0925-4927(98)00036-5 Plassmann H, 2008, P NATL ACAD SCI USA, V105, P1050, DOI 10.1073/pnas.0706929105 Rao SM, 2000, AM J PSYCHIAT, V157, P1697, DOI 10.1176/appi.ajp.157.10.1697 Schlosser R, 2003, NEUROIMAGE, V19, P751, DOI 10.1016/S1053-8119(03)00106-X Schmitz N, 2008, BRIT J PSYCHIAT, V192, P19, DOI 10.1192/bjp.bp.107.036921 Schultz RT, 2005, INT J DEV NEUROSCI, V23, P125, DOI 10.1016/j.ijdevneu.2004.12.012 Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331 Sears LL, 1999, PROG NEURO-PSYCHOPH, V23, P613, DOI 10.1016/S0278-5846(99)00020-2 Shohamy D, 2008, NEUROSCI BIOBEHAV R, V32, P219, DOI 10.1016/j.neubiorev.2007.07.008 Smith SM, 2002, HUM BRAIN MAPP, V17, P143, DOI 10.1002/hbm.10062 Snitz BE, 2005, AM J PSYCHIAT, V162, P2322, DOI 10.1176/appi.ajp.162.12.2322 SPRECKELMEYER KN, 2009, SOCIAL COGNITIVE AFF, DOI DOI 10.1093/SCAN/NSN051:NSN051 STERLING J, 1994, J AUTISM DEV DISORD, V24, P247 Takarae Y, 2007, PSYCHIAT RES-NEUROIM, V156, P117, DOI 10.1016/j.pseychresns.2007.03.008 Thut G, 1997, NEUROREPORT, V8, P1225, DOI 10.1097/00001756-199703240-00033 Triesch J, 2006, DEVELOPMENTAL SCI, V9, P125, DOI 10.1111/j.1467-7687.2006.00470.x Wager TD, 2003, NEUROIMAGE, V18, P293, DOI 10.1016/S1053-8119(02)00046-0 Wagner A.R., 1972, THEORY PAVLOVIAN CON Wechsler D, 1999, WECHSLER ABBREVIATED Wechsler D, 1991, WECHSLER INTELLIGENC, V3rd Woolrich MW, 2001, NEUROIMAGE, V14, P1370, DOI 10.1006/nimg.2001.0931 Young LJ, 2005, J COMP NEUROL, V493, P51, DOI 10.1002/cne.20771 Young LJ, 2004, NAT NEUROSCI, V7, P1048, DOI 10.1038/nn1327 NR 60 TC 73 Z9 74 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2010 VL 3 IS 2 BP 53 EP 67 DI 10.1002/aur.122 PG 15 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 590ED UT WOS:000277206100002 PM 20437601 ER PT J AU Travers, BG Klinger, MR Mussey, JL Klinger, LG AF Travers, Brittany G. Klinger, Mark R. Mussey, Joanna L. Klinger, Laura G. TI Motor-Linked Implicit Learning in Persons with Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE neuropsychology; implicit learning; sequence learning; autism spectrum disorders; serial response task ID SKILL; DISSOCIATION; EQUIVALENCE; ATTENTION; KNOWLEDGE; EXPLICIT; DEFICIT; SPEED; TIME AB Fifteen adolescents and young adults with high-functioning autism spectrum disorders (ASD) and 18 age- and IQ-matched adults with typical development (TD) completed a serial reaction time task (SRT) to examine possible motor-linked implicit learning impairments in persons with ASD. Measures were taken to decrease the role of explicit learning in the SRT. Results showed that participants with AS!) demonstrated intact motor-linked implicit learning. Furthermore, the motor-linked implicit learning appeared to take place at a similar rate across trials in the group with ASD compared to the group with TD. These results suggest that persons with AS!) are successful in implicit learning of motor-linked behavior. The results of this study, coupled with past findings, suggest that people with AS!) may be able to learn motor movements without conscious awareness, especially if the individual is older and is learning fine motor sequences. C1 [Travers, Brittany G.; Klinger, Mark R.; Mussey, Joanna L.; Klinger, Laura G.] Univ Alabama, Dept Psychol, Tuscaloosa, AL 35487 USA. RP Travers, BG (reprint author), Univ Alabama, Dept Psychol, Box 870348, Tuscaloosa, AL 35487 USA. EM bgtravers@crimson.ua.edu CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Barnes KA, 2008, NEUROPSYCHOLOGY, V22, P563, DOI 10.1037/0894-4105.22.5.563 COHEN NJ, 1980, SCIENCE, V210, P207, DOI 10.1126/science.7414331 Constantino JN, 2002, SOCIAL RESPONSIVENES Dawson G, 2000, J AUTISM DEV DISORD, V30, P415, DOI 10.1023/A:1005547422749 Destrebecqz A, 2003, ATTENTION IMPLICIT L, P181 Destrebecqz A, 2001, PSYCHON B REV, V8, P343, DOI 10.3758/BF03196171 Gomez RL, 1999, COGNITION, V70, P109, DOI 10.1016/S0010-0277(99)00003-7 Gordon B., 2007, FOCUS AUTISM OTHER D, V22, P14, DOI DOI 10.1177/10883576070220010201 Greenwald AG, 2003, J PERS SOC PSYCHOL, V85, P197, DOI 10.1037/0022-3514.85.2.197 Imam AA, 2006, J EXP ANAL BEHAV, V85, P107, DOI 10.1901/jeab.2006.58-04 Jimenez L, 2005, PSYCHOL RES-PSYCH FO, V69, P352, DOI 10.1007/s00426-004-0210-9 Kaufman A. S., 2004, KAUFMAN BRIEF INTELL Klinger LG, 2001, DEV PSYCHOPATHOL, V13, P111, DOI 10.1017/S0954579401001080 Klinger L.G., 2007, NEW DEV AUTISM FUTUR Larson J. C., 2006, AUTISM NEUROLOGICAL Lieberman MD, 2000, PSYCHOL BULL, V126, P109, DOI 10.1037//0033-2909.126.1.109 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C., 2000, J AUTISM DEV DISORD, V30, P1573 LOVAAS OI, 1979, PSYCHOL BULL, V86, P1236, DOI 10.1037//0033-2909.86.6.1236 Mostofsky SH, 2000, J INT NEUROPSYCH SOC, V6, P752, DOI 10.1017/S1355617700677020 Muller RA, 2004, BIOL PSYCHIAT, V56, P323, DOI 10.1016/j.biopsych.2004.06.007 NISSEN MJ, 1987, COGNITIVE PSYCHOL, V19, P1, DOI 10.1016/0010-0285(87)90002-8 POSNER MI, 1984, ATTENTION PERFORM, V10, P531 Rauch SL, 1997, J NEUROPSYCH CLIN N, V9, P568 REBER PJ, 1994, LEARN MEMORY, V1, P217 Reingold E. M., 1990, MIND LANG, V5, P9, DOI [10.1111/j.1468-0017.1990.tb00150.x, DOI 10.1111/J.1468-0017.1990.TB00150.X] Saffran JR, 1997, PSYCHOL SCI, V8, P101, DOI 10.1111/j.1467-9280.1997.tb00690.x SEGER CA, 1994, PSYCHOL BULL, V115, P163, DOI 10.1037/0033-2909.115.2.163 Seger CA, 1998, HDB IMPLICIT LEARNIN, P295 Spencer TJ, 1996, J EXP ANAL BEHAV, V65, P643, DOI 10.1901/jeab.1996.65-643 Sun R, 2001, COGNITIVE SCI, V25, P203, DOI 10.1016/S0364-0213(01)00035-0 Sun R, 2005, PSYCHOL REV, V112, P159, DOI 10.1037/0033-295X.112.1.159 TOWNSEND J, 1994, J COGNITIVE NEUROSCI, V6, P220, DOI 10.1162/jocn.1994.6.3.220 Vaquero JMM, 2006, EXP BRAIN RES, V175, P97, DOI 10.1007/s00221-006-0523-6 Wang LX, 2007, COGN NEUROPSYCHOL, V24, P550, DOI 10.1080/13546800701417096 NR 36 TC 11 Z9 11 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2010 VL 3 IS 2 BP 68 EP 77 DI 10.1002/aur.123 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 590ED UT WOS:000277206100003 PM 20437602 ER PT J AU Boyd, BA Baranek, GT Sideris, J Poe, MD Watson, LR Patten, E Miller, H AF Boyd, Brian A. Baranek, Grace T. Sideris, John Poe, Michele D. Watson, Linda R. Patten, Elena Miller, Heather TI Sensory Features and Repetitive Behaviors in Children with Autism and Developmental Delays SO AUTISM RESEARCH LA English DT Article DE autism; repetitive behaviors; responses to sensory stimuli; sensory symptoms ID OBSESSIVE-COMPULSIVE DISORDER; SPECTRUM DISORDERS; YOUNG-CHILDREN; TYPICAL DEVELOPMENT; ABNORMALITIES; INTEGRATION; ANNOTATION; ATTENTION; SYMPTOMS; TODDLERS AB This study combined parent and observational measures to examine the association between aberrant sensory features and restricted, repetitive behaviors in children with autism (N = 67) and those with developmental delays (N = 42). Confirmatory factor analysis was used to empirically validate three sensory constructs of interest: hyperresponsiveness, hyporesponsiveness, and sensory seeking. Examining the association between the three derived sensory factor scores and scores on the Repetitive Behavior Scales-Revised revealed the co-occurrence of these behaviors in both clinical groups. Specifically, high levels of hyperresponsive behaviors predicted high levels of repetitive behaviors, and the relationship between these variables remained the same controlling for mental age. We primarily found non-significant associations between hyporesponsiveness or sensory seeking and repetitive behaviors, with the exception that sensory seeking was associated with ritualistic/sameness behaviors. These findings suggest that shared neurobiological mechanisms may underlie hyperresponsive sensory symptoms and repetitive behaviors and have implications for diagnostic classification as well as intervention. C1 [Boyd, Brian A.; Baranek, Grace T.; Sideris, John; Poe, Michele D.; Watson, Linda R.; Patten, Elena; Miller, Heather] Univ N Carolina, Chapel Hill, NC USA. RP Boyd, BA (reprint author), Div Occupat Sci, CB 7122,UNC CH Bondurant Hall, Chapel Hill, NC 27599 USA. EM brian_boyd@med.unc.edu RI Poe, Michele/K-6615-2012 OI Poe, Michele/0000-0001-9693-3638 FU National Institute for Child Health and Human Development [R01-HD42168] FX This research was supported in part by a grant from the National Institute for Child Health and Human Development (R01-HD42168). We thank the families whose participation made this study possible. CR Abramowitz JS, 2005, BEHAV THER, V36, P55, DOI 10.1016/S0005-7894(05)80054-1 American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Aouizerate B, 2004, PROG NEUROBIOL, V72, P195, DOI 10.1016/j.pneurobio.2004.02.004 Baranek G. T., 1998, TACTILE DEFENS UNPUB Baranek G. T., 1999, SENSORY PROCES UNPUB Baranek G. T., 2005, HDB AUTISM PERVASIVE, VII, P831 Baranek G. T., 1999, SENSORY EXPERI UNPUB Baranek GT, 2007, AM J MENT RETARD, V112, P233, DOI 10.1352/0895-8017(2007)112[233:HSPIYC]2.0.CO;2 BARANEK GT, 1994, J AUTISM DEV DISORD, V24, P457, DOI 10.1007/BF02172128 Baranek GT, 2006, J CHILD PSYCHOL PSYC, V47, P591, DOI 10.1111/j.1469-7610.2005.01546.x Baron-Cohen S, 2009, PHILOS T R SOC B, V364, P1377, DOI 10.1098/rstb.2008.0337 Beck C T, 2001, J Nurs Meas, V9, P201 Ben-Sasson A, 2009, J AUTISM DEV DISORD, V39, P1, DOI 10.1007/s10803-008-0593-3 Ben-Sasson A, 2008, J CHILD PSYCHOL PSYC, V49, P817, DOI 10.1111/j.1469-7610.2008.01899.x Bishop SL, 2006, CHILD NEUROPSYCHOL, V12, P247, DOI 10.1080/09297040600630288 Blue CL, 2008, HEALTH EDUC BEHAV, V35, P316, DOI 10.1177/1090198106297060 Bodfish J.W., 1999, REPETITIVE BEHAV SCA Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855 Boyd BA, 2009, RES AUTISM SPECT DIS, V3, P959, DOI 10.1016/j.rasd.2009.05.003 Dawson G, 2008, DEV PSYCHOPATHOL, V20, P775, DOI 10.1017/S0954579408000370 Dunn W., 1999, SENSORY PROFILE Dziobek I, 2006, NEUROPSYCHOLOGIA, V44, P1891, DOI 10.1016/j.neuropsychologia.2006.02.005 Evans DW, 1999, CHILD PSYCHIAT HUM D, V29, P261, DOI 10.1023/A:1021392931450 Fiske AP, 1997, J NERV MENT DIS, V185, P211, DOI 10.1097/00005053-199704000-00001 Fitzner K, 2007, DIABETES EDUCATOR, V33, P775, DOI 10.1177/0145721707308172 Gabriels RL, 2008, RES AUTISM SPECT DIS, V2, P660, DOI 10.1016/j.rasd.2008.02.002 GAY E, 2008, GATL C RES THEOR INT Gomot M, 2008, BRAIN, V131, P2479, DOI 10.1093/brain/awn172 Gould J, 2008, J LEISURE RES, V40, P47 Grant JS, 1997, RES NURS HEALTH, V20, P269, DOI 10.1002/(SICI)1098-240X(199706)20:3<269::AID-NUR9>3.3.CO;2-3 Greenspan S. I., 1997, J DEV LEARNING DISOR, V1, P87 Hirstein W, 2001, P ROY SOC B-BIOL SCI, V268, P1883, DOI 10.1098/rspb.2001.1724 Iarocci G, 2006, J AUTISM DEV DISORD, V36, P77, DOI 10.1007/s10803-005-0044-3 Lam KSL, 2007, J AUTISM DEV DISORD, V37, P855, DOI 10.1007/s10803-006-0213-z Langen M, 2007, BIOL PSYCHIAT, V62, P262, DOI 10.1016/j.biopsych.2006.09.040 Le Couteur A., 2003, AUTISM DIAGNOSTIC IN Liss M, 2006, AUTISM, V10, P155, DOI 10.1177/1362361306062021 Lord C., 1999, AUTISM DIAGNOSTIC OB LOVAAS OI, 1987, J APPL BEHAV ANAL, V21, P281 MCDONALD JF, 1980, REV ECON STAT, V62, P318, DOI 10.2307/1924766 Miller LJ, 2007, AM J OCCUP THER, V61, P135 Mosconi MW, 2009, PSYCHOL MED, V39, P1559, DOI 10.1017/S0033291708004984 Mullen E, 1995, MULLEN SCALES EARLY Piacentini J, 2004, J CLIN PSYCHOL, V60, P1181, DOI 10.1002/jclp.20082 Rapoport JL, 2000, J CHILD PSYCHOL PSYC, V41, P419, DOI 10.1017/S0021963000005588 Rogers SJ, 2003, J AUTISM DEV DISORD, V33, P631, DOI 10.1023/B:JADD.0000006000.38991.a7 Rogers SJ, 2005, J CHILD PSYCHOL PSYC, V46, P1255, DOI 10.1111/j.1469-7610.2005.01431.x Roid G., 1997, LEITER INT PERFORMAN Schopler E., 1988, CHILDHOOD AUTISM RAT Shafritz KM, 2008, BIOL PSYCHIAT, V63, P974, DOI 10.1016/j.biopsych.2007.06.028 Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099 Tommerdahl M, 2008, BEHAV BRAIN FUNCT, V4, P1 Turner M, 1999, J CHILD PSYCHOL PSYC, V40, P839, DOI 10.1017/S0021963099004278 Watling RL, 2001, AM J OCCUP THER, V55, P416 WHO, 1993, ICD 10 CLASS MENT BE WILLIAMS D, 1994, NOBODY NOWHERE Zohar AH, 2001, J ABNORM CHILD PSYCH, V29, P121, DOI 10.1023/A:1005231912747 NR 57 TC 42 Z9 42 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2010 VL 3 IS 2 BP 78 EP 87 DI 10.1002/aur.124 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 590ED UT WOS:000277206100004 PM 20437603 ER PT J AU Best, CA Minshew, NJ Strauss, MS AF Best, Catherine A. Minshew, Nancy J. Strauss, Mark S. TI Gender Discrimination of Eyes and Mouths by Individuals with Autism SO AUTISM RESEARCH LA English DT Article DE autism; gender discrimination; face perception; facial features ID HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; FACE; RECOGNITION; INFORMATION; FIXATION; CHILDREN; GAZE; COMPETENCE; ATTENTION AB Evidence remains mixed about whether individuals with autism look less to eyes and whether they look more at mouths. Few studies have examined how spontaneous attention to facial features relates to face processing abilities. This study tested the ability to discriminate gender from facial features, namely eyes and mouths, by comparing accuracy scores of 17 children with autism and 15 adults with autism to 17 typically developing children and 15 typically developing adults. Results indicated that all participants regardless of diagnosis discriminated gender more accurately from eyes than from mouths. However, results indicated that compared to adults without autism, adults with autism were significantly worse at discriminating gender from eyes. C1 [Best, Catherine A.; Strauss, Mark S.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA. [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat & Neurol, Pittsburgh, PA 15260 USA. RP Strauss, MS (reprint author), Univ Pittsburgh, Dept Psychol, 210 S Bouquet St, Pittsburgh, PA 15260 USA. EM strauss@pitt.edu FU NIH [P01-HD354-69] FX This research was supported by a NIH Collaborative Program of Excellence in Autism (CPEA) Grant P01-HD354-69 to Nancy J. Minshew and Mark S. Strauss. We are grateful to the participants and their families for making this research possible and to the CPEA staff for their efforts in recruiting and scheduling participants. We especially thank Holly Gastgeb and Keiran Rump for their time testing participants. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT Bar-Haim Y, 2006, J AUTISM DEV DISORD, V36, P131, DOI 10.1007/s10803-005-0046-1 Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643 Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002 BURTON AM, 1993, PERCEPTION, V22, P153, DOI 10.1068/p220153 Campbell R, 1999, PERCEPTION, V28, P489, DOI 10.1068/p2784 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Fletcher-Watson S, 2009, NEUROPSYCHOLOGIA, V47, P248, DOI 10.1016/j.neuropsychologia.2008.07.016 Gastgeb HZ, 2006, CHILD DEV, V77, P1717, DOI 10.1111/j.1467-8624.2006.00969.x Hernandez N, 2009, NEUROPSYCHOLOGIA, V47, P1004, DOI 10.1016/j.neuropsychologia.2008.10.023 HOBSON RP, 1988, BRIT J PSYCHOL, V79, P441 Joseph RM, 2003, J CHILD PSYCHOL PSYC, V44, P529, DOI 10.1111/1469-7610.00142 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 LANGDELL T, 1978, J CHILD PSYCHOL PSYC, V19, P255, DOI 10.1111/j.1469-7610.1978.tb00468.x Lord C, 2003, AUTISM DIAGNOSTIC OB MCPARTLAND JC, 2005, THESIS U WASHINGTON Merin N, 2007, J AUTISM DEV DISORD, V37, P108, DOI 10.1007/s10803-006-0342-4 Neumann D, 2006, SOC COGN AFFECT NEUR, V1, P194, DOI 10.1093/scan/nsl030 NEWELL LC, 2010, EARLY PERCEPTUAL COG Norbury CF, 2009, J CHILD PSYCHOL PSYC, V50, P834, DOI 10.1111/j.1469-7610.2009.02073.x O'Toole AJ, 1998, MEM COGNITION, V26, P146, DOI 10.3758/BF03211378 Pelphrey KA, 2002, J AUTISM DEV DISORD, V32, P249, DOI 10.1023/A:1016374617369 Riby DM, 2009, Q J EXP PSYCHOL, V62, P189, DOI 10.1080/17470210701855629 ROBERTS T, 1988, PERCEPTION, V17, P475, DOI 10.1068/p170475 RUMP KM, 2010, CHILD DEV, V80, P1434 Rutherford MD, 2007, VISION RES, V47, P2099, DOI 10.1016/j.visres.2007.01.029 Rutter M., 2003, AUTISM DIAGNOSTIC IN Schyns PG, 2002, PSYCHOL SCI, V13, P402, DOI 10.1111/1467-9280.00472 Spezio ML, 2007, NEUROPSYCHOLOGIA, V45, P144, DOI 10.1016/j.neuropsychologia.2006.04.027 Spezio ML, 2007, J AUTISM DEV DISORD, V37, P929, DOI 10.1007/s10803-006-0232-9 van der Geest JN, 2002, J CHILD PSYCHOL PSYC, V43, P669, DOI 10.1111/1469-7610.00055 Wechsler D, 1999, WECHSLER ABBREVIATED Weissman MM, 2000, ARCH GEN PSYCHIAT, V57, P675, DOI 10.1001/archpsyc.57.7.675 NR 33 TC 7 Z9 7 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2010 VL 3 IS 2 BP 88 EP 93 DI 10.1002/aur.125 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 590ED UT WOS:000277206100005 PM 20437604 ER PT J AU Shelton, JF Tancredi, DJ Hertz-Picciotto, I AF Shelton, Janie F. Tancredi, Daniel J. Hertz-Picciotto, Irva TI Independent and Dependent Contributions of Advanced Maternal and Paternal Ages to Autism Risk (vol 3, pg 30, 2010) SO AUTISM RESEARCH LA English DT Correction C1 [Shelton, Janie F.; Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA. [Tancredi, Daniel J.] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA. [Tancredi, Daniel J.] Univ Calif Davis, Ctr Healthcare Policy & Res, Davis, CA 95616 USA. [Hertz-Picciotto, Irva] UC Davis MIND Inst, Sacramento, CA USA. RP Shelton, JF (reprint author), Univ Calif Davis, Dept Publ Hlth Sci, MS1C, Davis, CA 95616 USA. EM jfshelton@ucdavis.edu CR Shelton JF, 2010, AUTISM RES, V3, P30, DOI 10.1002/aur.116 NR 1 TC 1 Z9 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD APR PY 2010 VL 3 IS 2 BP 98 EP 98 DI 10.1002/aur.135 PG 1 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 590ED UT WOS:000277206100006 ER PT J AU Owley, T Brune, CW Salt, J Walton, L Guter, S Ayuyao, N Gibbons, RD Leventhal, BL Cook, EH AF Owley, Thomas Brune, Camille W. Salt, Jeff Walton, Laura Guter, Steve Ayuyao, Nelson Gibbons, Robert D. Leventhal, Bennett L. Cook, Edwin H. TI A Pharmacogenetic Study of Escitalopram in Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE autistic disorder; escitalopram; pharmacogenetics; open label; drug treatment ID PERVASIVE DEVELOPMENTAL DISORDERS; SEROTONIN TRANSPORTER GENE; OBSESSIVE-COMPULSIVE DISORDER; MENTAL-RETARDATION; CLINICAL-TRIALS; MISSING DATA; DOUBLE-BLIND; CHILDREN; FLUOXETINE; CITALOPRAM AB To determine the effect of serotonin transporter polymorphism promoter region (5-HTTPLR) genotypic variation (low, intermediate, and high expression groups) on response to escitalopram treatment of children and adolescents with autism spectrum disorders (ASDs). Method: The study used a forced titration, open label design, with genotype blind until study completion. Participants were children and adolescents aged 4-17 years of age with a confirmed ASD (autistic disorder, Asperger's disorder, or pervasive developmental disorder, not otherwise specified). Results: There was an interaction between genotype group and time on the Aberrant Behavior Checklist (ABC) Irritability Subscale (primary outcome variable) (linear maximum marginal likelihood estimation = -4.84, Z = -2.89, SE = 1.67, P = 0.004). Examination of baseline to last visit revealed that a genotype grouping based on a previous study of platelet 5-HT uptake revealed less response in the genotype group that had S/S genotype for 5-HTTLPR and did not have a diplotype in intron 1 previously shown to be associated with increased platelet 5-HT uptake. Conclusion: This genotype-blind, prospective pharmacogenetic study found the group of subjects with associated with the lowest platelet 5-HT uptake from previous study had the smallest reduction in ABC-Irritability scores after open label treatment with escitalopram. Replication is necessary to confirm these findings. C1 [Owley, Thomas; Brune, Camille W.; Salt, Jeff; Walton, Laura; Guter, Steve; Ayuyao, Nelson; Leventhal, Bennett L.; Cook, Edwin H.] Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA. [Gibbons, Robert D.] Univ Illinois, Dept Biostat, Chicago, IL 60608 USA. RP Brune, CW (reprint author), Univ Illinois, Dept Psychiat, Inst Juvenile Res, 1747 W Roosevelt Rd,Room 155, Chicago, IL 60608 USA. EM cbrune@psych.uic.edu FU Autism Speaks Post-doctoral Fellowship; National Institute of Health [KO1 MI-164539, U19 HD35482, P50 HD055751] FX Grant sponsors: Autism Speaks Post-doctoral Fellowship; National Institute of Health; Grant numbers: KO1 MI-164539; U19 HD35482; P50 HD055751. CR AMAN MG, 1985, AM J MENT DEF, V89, P485 American Psychiatric Association (APA), 1994, DIAGN STAT MAN MENT, V4th Benedetti F, 2003, J CLIN PSYCHIAT, V64, P648 Buchsbaum MS, 2001, INT J NEUROPSYCHOPH, V4, P119 COOK EH, 1992, J AM ACAD CHILD PSY, V31, P739, DOI 10.1097/00004583-199207000-00024 Cross S, 2008, NEUROPSYCHOPHARMACOL, V33, P353, DOI 10.1038/sj.npp.1301406 DeLong GR, 2002, DEV MED CHILD NEUROL, V44, P652 Hamer RM, 2009, AM J PSYCHIAT, V166, P639, DOI 10.1176/appi.ajp.2009.09040458 Hedeker D. R., 2006, LONGITUDINAL DATA AN Heils A, 1996, J NEUROCHEM, V66, P2621 Hellings JA, 1996, J CLIN PSYCHIAT, V57, P333 Hollander E, 2005, NEUROPSYCHOPHARMACOL, V30, P582, DOI 10.1038/sj.npp.1300627 Hu XZ, 2006, AM J HUM GENET, V78, P815, DOI 10.1086/503850 JASELSKIS CA, 1992, J CLIN PSYCHOPHARM, V12, P322 Kim SJ, 2002, MOL PSYCHIATR, V7, P278, DOI 10.1038/sj/mp/4001033 King BH, 2001, J AM ACAD CHILD PSY, V40, P658, DOI 10.1097/00004583-200106000-00010 King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30 Kirchheiner Julia, 2006, J Psychopharmacol, V20, P27, DOI 10.1177/1359786806066043 LAIRD NM, 1982, BIOMETRICS, V38, P963, DOI 10.2307/2529876 Lavori PW, 2008, PSYCHIAT ANN, V38, P784 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P1001 McDougle CJ, 1998, MOL PSYCHIATR, V3, P270, DOI 10.1038/sj.mp.4000391 McDougle CJ, 2000, CHILD ADOL PSYCH CL, V9, P201 Namerow LB, 2003, J DEV BEHAV PEDIATR, V24, P104 Owley T, 2005, J AM ACAD CHILD PSY, V44, P343, DOI 10.1097/01.chi.0000153229.80215.a0 Posey DJ, 2006, J CHILD ADOL PSYCHOP, V16, P181, DOI 10.1089/cap.2006.16.181 Risi S, 2006, J AM ACAD CHILD PSY, V45, P1094, DOI 10.1097/01.chi.0000227880.42780.0e Siddique J, 2008, PSYCHIAT ANN, V38, P793 Sugie Y, 2005, J AUTISM DEV DISORD, V35, P377, DOI 10.1007/s10803-005-3305-2 Zanardi R, 2007, EUR NEUROPSYCHOPHARM, V17, P651, DOI 10.1016/j.euroneuro.2007.03.008 NR 32 TC 11 Z9 12 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2010 VL 3 IS 1 BP 1 EP 7 DI 10.1002/aur.109 PG 7 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 565MH UT WOS:000275296800001 PM 20020537 ER PT J AU Roberts, TPL Khan, SY Rey, M Monroe, JF Cannon, K Blaskey, L Woldoff, S Qasmieh, S Gandal, M Schmidt, GL Zarnow, DM Levy, SE Edgar, JC AF Roberts, Timothy P. L. Khan, Sarah Y. Rey, Mike Monroe, Justin F. Cannon, Katelyn Blaskey, Lisa Woldoff, Sarah Qasmieh, Saba Gandal, Mike Schmidt, Gwen L. Zarnow, Deborah M. Levy, Susan E. Edgar, J. Christopher TI MEG Detection of Delayed Auditory Evoked Responses in Autism Spectrum Disorders: Towards an Imaging Biomarker for Autism SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorders; M50; M100; magnetoencephalography; language impairment; auditory evoked response ID EVENT-RELATED POTENTIALS; MIDDLE LATENCY COMPONENTS; MAGNETIC-FIELDS; HEALTHY-CHILDREN; EEG; METHYLPHENIDATE; ABNORMALITIES; TOPOGRAPHY; CORTEX; WAVES AB Motivated by auditory and speech deficits in autism spectrum disorders (ASD), the frequency dependence of superior temporal gyrus (STG) 50 msec (M50) and 100 msec (M100) neuromagnetic auditory evoked field responses in children with ASD and typically developing controls were evaluated. Whole-cortex magnetoencephalography (MEG) was obtained from 17 typically developing children and 25 children with ASD. Subjects were presented tones with frequencies of 200, 300, 500, and 1,000 Hz, and left and right STG M50 and M100 STG activity was examined. No M50 latency or amplitude Group differences were observed. In the right hemisphere, a Group x Frequency ANOVA on M100 latency produced a main effect for Group (P = 0.01), with an average M100 latency delay of 11 msec in children with ASD. In addition, only in the control group was the expected association of earlier M100 latencies in older than younger children observed. Group latency differences remained significant when hierarchical regression analyses partialed out M100 variance associated with age, IQ, and language ability (all P-values <0.05). Examining the right-hemisphere 500 Hz condition (where the largest latency differences were observed), a sensitivity of 75%, a specificity of 81%, and a positive predictive value (PPV) of 86% was obtained at a threshold of 116 msec. The M100 latency delay indicates disruption of encoding simple sensory information. Given similar findings in language impaired and nonlanguage impaired ASD subjects, a right-hemisphere M100 latency delay appears to be an electrophysiological endophenotype for autism. C1 [Roberts, Timothy P. L.; Khan, Sarah Y.; Rey, Mike; Monroe, Justin F.; Cannon, Katelyn; Gandal, Mike; Schmidt, Gwen L.; Zarnow, Deborah M.; Edgar, J. Christopher] Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA. [Blaskey, Lisa; Woldoff, Sarah; Qasmieh, Saba; Levy, Susan E.; Edgar, J. Christopher] Childrens Hosp Philadelphia, Dept Radiol & Pediat, Philadelphia, PA 19104 USA. [Edgar, J. Christopher] New Mexico VA Healthcare Syst, Funct Brain Imaging, Albuquerque, NM USA. RP Roberts, TPL (reprint author), Childrens Hosp Philadelphia, Dept Radiol, Wood Bldg,Suite 2115,34th St & Civ Ctr Blvd, Philadelphia, PA 19104 USA. EM robertstim@email.chop.edu FU NIH [RO1 DC008871]; The Nancy Lurie Marks Family Foundation (NLMFF); Autism Speaks; Pennsylvania Department of Health FX Grant sponsor: NIH; Grant number: RO1 DC008871; Grant sponsors: The Nancy Lurie Marks Family Foundation (NLMFF); Autism Speaks; The Pennsylvania Department of Health. CR Arick J. R., 2003, KRUG ASPERGERS DISOR BERG P, 1994, ELECTROEN CLIN NEURO, V90, P229, DOI 10.1016/0013-4694(94)90094-9 Bomba MD, 2004, INT J PSYCHOPHYSIOL, V53, P161, DOI 10.1016/j.ijpsycho.2004.04.001 Bruneau N, 1999, CLIN NEUROPHYSIOL, V110, P1927, DOI 10.1016/S1388-2457(99)00149-2 Cardy JEO, 2004, NEUROREPORT, V15, P1867 Cardy JEO, 2008, INT J PSYCHOPHYSIOL, V68, P170, DOI 10.1016/j.ijpsycho.2007.10.015 Constantino JN, 2005, SOCIAL RESPONSIVENES DAWSON G, 1986, CHILD DEV, V57, P1440, DOI 10.1111/j.1467-8624.1986.tb00469.x Dunn M, 1999, DEV NEUROPSYCHOL, V16, P79, DOI 10.1207/S15326942DN160105 Edgar JC, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P665 Edgar JC, 2003, BIOL PSYCHOL, V65, P1, DOI 10.1016/S0301-0511(03)00094-2 Eggermont JJ, 1997, ACTA OTO-LARYNGOL, V117, P161, DOI 10.3109/00016489709117760 Ferri R, 2003, CLIN NEUROPHYSIOL, V114, P1671, DOI 10.1016/S1388-2457(03)00153-6 Gage NM, 2003, NEUROREPORT, V14, P2047, DOI 10.1097/01.wnr.0000090030.460874a Gage NM, 2003, DEV BRAIN RES, V144, P201, DOI 10.1016/S0165-3806(03)00172-X Hari R, 1990, ADV AUDIOL, V6, P222 Huotilainen M, 1998, EVOKED POTENTIAL, V108, P370, DOI 10.1016/S0168-5597(98)00017-3 Jeste SS, 2009, J AUTISM DEV DISORD, V39, P495, DOI 10.1007/s10803-008-0652-9 JIRSA RE, 1990, EAR HEARING, V11, P222, DOI 10.1097/00003446-199006000-00010 KEMNER C, 1995, BIOL PSYCHIAT, V38, P150, DOI 10.1016/0006-3223(94)00247-Z Korostenskaja M, 2008, PSYCHOPHARMACOLOGY, V197, P475, DOI 10.1007/s00213-007-1065-8 Korpilahti P, 2007, J AUTISM DEV DISORD, V37, P1539, DOI 10.1007/s10803-006-0271-2 LEE YS, 1984, BRAIN, V107, P115, DOI 10.1093/brain/107.1.115 LIEGEOISCHAUVEL C, 1994, ELECTROEN CLIN NEURO, V92, P204, DOI 10.1016/0168-5597(94)90064-7 LINCOLN AJ, 1995, J AUTISM DEV DISORD, V25, P521, DOI 10.1007/BF02178298 Lins Otavio G., 1993, Brain Topography, V6, P65, DOI 10.1007/BF01234128 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 MAKELA JP, 1994, ELECTROEN CLIN NEURO, V92, P414, DOI 10.1016/0168-5597(94)90018-3 MARTINEAU J, 1984, ANN NY ACAD SCI, V425, P362, DOI 10.1111/j.1749-6632.1984.tb23557.x NOVICK B, 1980, PSYCHIAT RES, V3, P107, DOI 10.1016/0165-1781(80)90052-9 OADES RD, 1988, INT J PSYCHOPHYSIOL, V6, P25, DOI 10.1016/0167-8760(88)90032-3 PAETAU R, 1995, J CLIN NEUROPHYSIOL, V12, P177, DOI 10.1097/00004691-199503000-00008 PELIZZONE M, 1987, NEUROSCI LETT, V82, P303, DOI 10.1016/0304-3940(87)90273-4 Picton TW, 1999, AUDIOL NEURO-OTOL, V4, P64, DOI 10.1159/000013823 REITE M, 1988, ELECTROEN CLIN NEURO, V70, P490, DOI 10.1016/0013-4694(88)90147-2 Roberts TPL, 2000, J CLIN NEUROPHYSIOL, V17, P114, DOI 10.1097/00004691-200003000-00002 Roberts TPL, 1996, NEUROREPORT, V7, P1138, DOI 10.1097/00001756-199604260-00007 Rutter M., 2003, SCQ SOCIAL COMMUNICA Scherg M., 1990, AUDITORY EVOKED MAGN, P40 SCHERG M, 1985, ELECTROEN CLIN NEURO, V62, P290, DOI 10.1016/0168-5597(85)90006-1 Scherg M, 2002, J CLIN NEUROPHYSIOL, V19, P91, DOI 10.1097/00004691-200203000-00001 Scherg M, 1996, Electroencephalogr Clin Neurophysiol Suppl, V46, P127 SCHERG M, 1994, NEUROPHYSIOL CLIN, V24, P51, DOI 10.1016/S0987-7053(05)80405-8 Semel E., 2003, CLIN EVALUATION LANG, V4th Seri S, 1999, CLIN NEUROPHYSIOL, V110, P1825, DOI 10.1016/S1388-2457(99)00137-6 Sokhadze E, 2009, APPL PSYCHOPHYS BIOF, V34, P37, DOI 10.1007/s10484-009-9074-5 Tecchio F, 2003, BIOL PSYCHIAT, V54, P647, DOI 10.1016/S0006-3223(03)00295-6 TONNQUISTUHLEN I, 1995, ELECTROEN CLIN NEURO, V95, P34, DOI 10.1016/0013-4694(95)00044-Y VERBATEN MN, 1994, J ABNORM CHILD PSYCH, V22, P561, DOI 10.1007/BF02168938 Wechsler D., 2003, WECHSLER INTELLIGENC Yoshiura T, 1995, BRAIN RES, V703, P139, DOI 10.1016/0006-8993(95)01075-0 Yvert B, 2001, CEREB CORTEX, V11, P411, DOI 10.1093/cercor/11.5.411 NR 52 TC 57 Z9 59 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2010 VL 3 IS 1 BP 8 EP 18 DI 10.1002/aur.111 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 565MH UT WOS:000275296800002 PM 20063319 ER PT J AU Van Meter, KC Christiansen, LE Delwiche, LD Azari, R Carpenter, TE Hertz-Picciotto, I AF Van Meter, Karla C. Christiansen, Lasse E. Delwiche, Lora D. Azari, Rahman Carpenter, Tim E. Hertz-Picciotto, Irva TI Geographic Distribution of Autism in California: A Retrospective Birth Cohort Analysis SO AUTISM RESEARCH LA English DT Article DE autism; cluster; environmental; epidemiology; scan tests; spatial; geographic; sociodemographic ID US METROPOLITAN-AREA; SPECTRUM DISORDERS; RISK-FACTORS; PERINATAL FACTORS; PATERNAL AGE; POPULATION; PREVALENCE; CLUSTERS; CHILDREN AB Prenatal environmental exposures are among the risk factors being explored for associations with autism. We applied a new procedure combining multiple scan cluster detection tests to identify geographically defined areas of increased autism incidence. This procedure can serve as a first hypothesis-generating step aimed at localized environmental exposures, but would not be useful for assessing widely distributed exposures, such as household products, nor for exposures from nonpoint sources, such as traffic. Geocoded mothers' residences on 2,453,717 California birth records, 1996-2000, were analyzed including 9,900 autism cases recorded in the California Department of Developmental Services (DDS) database through February 2006 which were matched to their corresponding birth records. We analyzed each of the 21 DDS Regional Center (RC) catchment areas separately because of the wide variation in diagnostic practices. Ten clusters of increased autism risk were identified in eight RC regions, and one Potential Cluster in each of two other RC regions. After determination of clusters, multiple mixed Poisson regression models were fit to assess differences in known demographic autism risk factors between the births within and outside areas of elevated autism incidence, independent of case status. Adjusted for other covariates, the majority of areas of autism clustering were characterized by high parental education, e.g. relative risks >4 for college-graduate vs. nonhigh-school graduate parents. This geographic association possibly occurs because RCs do not actively conduct case finding and parents with lower education are, for various reasons, less likely to successfully seek services. C1 [Van Meter, Karla C.; Christiansen, Lasse E.; Carpenter, Tim E.] Univ Calif Davis, Sch Vet Med, Ctr Anim Dis Modeling & Surveillance, Davis, CA 95616 USA. [Van Meter, Karla C.; Delwiche, Lora D.; Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Sch Med, Davis, CA 95616 USA. [Van Meter, Karla C.; Delwiche, Lora D.; Hertz-Picciotto, Irva] Univ Calif Davis, Med Invest Neurodev Disorders Inst, Davis, CA 95616 USA. [Christiansen, Lasse E.] Tech Univ Denmark, DK-2800 Lyngby, Denmark. [Azari, Rahman] Univ Calif Davis, Dept Stat, Davis, CA 95616 USA. [Carpenter, Tim E.] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA. [Hertz-Picciotto, Irva] Univ Calif Davis, Sch Vet Med, Ctr Childrens Environm Hlth, Davis, CA 95616 USA. RP Van Meter, KC (reprint author), Univ Calif Davis, Sch Vet Med, Ctr Anim Dis Modeling & Surveillance, 1 Shields Ave,1044 Haring Hall, Davis, CA 95616 USA. EM vanmeter@pobox.com FU NIEHS P01 [ES11269]; NIEHS 01 [ES015359]; EPA STAR [8829388]; UC Davis M.I.N.D. Institute; UC Davis Center for Animal Disease Modeling and Surveillance (CADMS) FX Grant sponsor: NIEHS P01; Grant number: ES11269; Grant sponsor: NIEHS 01; Grant number: ES015359; Grant sponsor: EPA STAR; Grant number: 8829388; Grant sponsors: . CR AKAIKE H, 1992, No To Hattatsu, V24, P127 Baird G, 2006, LANCET, V368, P210, DOI 10.1016/S0140-6736(06)69041-7 Bhasin TK, 2007, J AUTISM DEV DISORD, V37, P667, DOI 10.1007/s10803-006-0194-y Christiansen LE, 2006, J AGR BIOL ENVIR ST, V11, P411, DOI 10.1198/108571106X154858 Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950 Croen LA, 2002, J AUTISM DEV DISORD, V32, P207, DOI 10.1023/A:1015453830880 Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334 *CTR HLTH STAT, 1996, CONF BIRTH 980 BYT F DiGiuseppe David L, 2002, Matern Child Health J, V6, P169, DOI 10.1023/A:1019726112597 Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618 Gregorio D, 2005, INT J HEALTH GEOGR, V4, P6, DOI 10.1186/1476-072X-4-6 Juul-Dam N, 2001, PEDIATRICS, V107, part. no., DOI 10.1542/peds.107.4.e63 Kulldorff M, 1997, COMMUN STAT-THEOR M, V26, P1481, DOI 10.1080/03610929708831995 Kulldorff M, 1997, AM J EPIDEMIOL, V146, P161 Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123 Larsson HJ, 2005, AM J EPIDEMIOL, V161, P926, DOI DOI 10.1093/AJE/KWI123 Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x Palmer RF, 2006, HEALTH PLACE, V12, P203, DOI 10.1016/j.healthplace.2004.11.005 Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026 Roberts EM, 2007, ENVIRON HEALTH PERSP, V115, P1482, DOI 10.1289/ehp.10168 Roohan PJ, 2003, J COMMUN HEALTH, V28, P335, DOI 10.1023/A:1025492512915 Tango Toshiro, 2005, Int J Health Geogr, V4, P11, DOI 10.1186/1476-072X-4-11 Tango T, 2000, STAT MED, V19, P191, DOI 10.1002/(SICI)1097-0258(20000130)19:2<191::AID-SIM281>3.0.CO;2-Q Van Meter KC, 2008, INT J HEALTH GEOGR, V7, DOI 10.1186/1476-072X-7-26 Waller LA, 2006, STAT MED, V25, P853, DOI 10.1002/sim.2418 Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120 Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49 1999, INT CLASSIFICATION D NR 28 TC 26 Z9 27 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2010 VL 3 IS 1 BP 19 EP 29 DI 10.1002/aur.110 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 565MH UT WOS:000275296800003 PM 20049980 ER PT J AU Shelton, JF Tancredi, DJ Hertz-Picciotto, I AF Shelton, Janie F. Tancredi, Daniel J. Hertz-Picciotto, Irva TI Independent and Dependent Contributions of Advanced Maternal and Paternal Ages to Autism Risk SO AUTISM RESEARCH LA English DT Article DE autism; maternal age; paternal age; effect measure modification; attributable risk; advanced maternal age; advanced paternal age; interaction ID REPRODUCTIVE TECHNOLOGY SURVEILLANCE; SPECTRUM DISORDERS; PERINATAL FACTORS; UNITED-STATES; BIRTH; PREVALENCE; CHILDHOOD AB Reports on autism and parental age have yielded conflicting results on whether mothers, fathers, or both, contribute to increased risk. We analyzed restricted strata of parental age in a 10-year California birth cohort to determine the independent or dependent effect from each parent. Autism cases from California Department of Developmental Services records were linked to State birth files (1990-1999). Only singleton births with complete data on parental age and education were included (n = 4,947,935, cases = 12,159). In multivariate logistic regression models, advancing maternal age increased risk for autism monotonically regardless of the paternal age. Compared with mothers 25-29 years of age, the adjusted odds ratio (aOR) for mothers 40+ years was 1.51 (95% Cl: 1.35-1.70), or compared with mothers <25 years of age, aOR = 1.77 (95% Cl, 1.56-2.00). In contrast, autism risk was associated with advancing paternal age primarily among mothers <30: aOR = 1.59 (95% CI, 1.37-1.85) comparing fathers 40+ vs. 25-29 years of age. However, among mothers > 30, the aOR was 1.13 (95% CI, 1.01-1.27) for fathers 40+ vs. 25-29 years of age, almost identical to the aOR for fathers <25 years. Based on the first examination of heterogeneity in parental age effects, it appears that women's risk for delivering a child who develops autism increases throughout their reproductive years whereas father's age confers increased risk for autism when mothers are <30, but has little effect when mothers are past age 30. We also calculated that the recent trend towards delayed childbearing contributed approximately a 4.6% increase in autism diagnoses in California over the decade. C1 [Shelton, Janie F.] Univ Calif Davis, Dept Publ Hlth Sci, MSIC, Davis, CA 95616 USA. [Tancredi, Daniel J.] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA. [Tancredi, Daniel J.] Univ Calif Davis, Ctr Healthcare Policy & Res, Davis, CA 95616 USA. [Hertz-Picciotto, Irva] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA. RP Shelton, JF (reprint author), Univ Calif Davis, Dept Publ Hlth Sci, MSIC, Davis, CA 95616 USA. EM jfshelton@ucdavis.edu FU NIEHS [P01-11269, R01-015359]; U.S. EPA [R-829388, R833292]; UC Davis School of Medicine and Office of Graduate Studies FX We acknowledge Jasmine Nettiksimmons for her generous assistance with the visualization of our data in Figures 1A and B. Special thanks to Lora Delwiche for her work preparing this dataset. This work was supported by grants from NIEHS (P01-11269, R01-015359), and the U.S. EPA (STAR #R-829388 & R833292) and the UC Davis School of Medicine and Office of Graduate Studies. CR American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Andersen AMN, 2004, AM J EPIDEMIOL, V160, P1214, DOI 10.1093/aje/kwh332 BERKOWITZ GS, 1990, NEW ENGL J MED, V322, P659, DOI 10.1056/NEJM199003083221004 Blaxill MF, 2004, PUBLIC HEALTH REP, V119, P536, DOI 10.1016/j.phr.2004.09.003 Braunschweig D, 2008, NEUROTOXICOLOGY, V29, P226, DOI 10.1016/j.neuro.2007.10.010 Brimacombe M, 2007, MATERN CHILD HLTH J, V11, P73, DOI 10.1007/s10995-006-0142-7 Brown AS, 2002, AM J PSYCHIAT, V159, P1528, DOI 10.1176/appi.ajp.159.9.1528 *CDC, 2004, NAT VIT STAT REP, V55 Croen LA, 2007, ARCH PEDIAT ADOL MED, V161, P334, DOI 10.1001/archpedi.161.4.334 Dockerty JD, 2001, INT J EPIDEMIOL, V30, P1428, DOI 10.1093/ije/30.6.1428 DURKIN MS, 2008, AM J EPIDEMIOL, P1268 Fombonne E., 2005, HDB AUTISM PERVASIVE, V1, P42 Fraga MF, 2007, TRENDS GENET, V23, P413, DOI 10.1016/j.tig.2007.05.008 Glasson EJ, 2004, ARCH GEN PSYCHIAT, V61, P618, DOI 10.1001/archpsyc.61.6.618 Harlap S, 2002, EPIDEMIOLOGY, V13, P660, DOI 10.1097/01.EDE.0000031708.99480.70 Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483 Hertz-Picciotto I, 2009, EPIDEMIOLOGY, V20, P84, DOI 10.1097/EDE.0b013e3181902d15 JOHNSON HP, 2007, BIRTH RATES CALIFORN, V9 King MD, 2009, AM J PUBLIC HEALTH, V99, P1673, DOI 10.2105/AJPH.2008.149021 Larbi A, 2008, ADV EXP MED BIOL, V640, P312, DOI 10.1007/978-0-387-09789-3_21 Larsson HJ, 2005, AM J EPIDEMIOL, V161, P916, DOI 10.1093/aje/kwi123 Larsson HJ, 2005, AM J EPIDEMIOL, V161, P926, DOI DOI 10.1093/AJE/KWI123 Lauritsen MB, 2005, J CHILD PSYCHOL PSYC, V46, P963, DOI 10.1111/j.1469-7610.2004.00391.x Lauritsen MB, 2004, PSYCHOL MED, V34, P1339, DOI 10.1017/S0033291704002387 Martin RH, 2008, REPROD BIOMED ONLINE, V16, P523 Middelburg KJ, 2008, HUM REPROD UPDATE, V14, P219, DOI 10.1093/humupd/dmn005 Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472 Reichenberg A, 2006, ARCH GEN PSYCHIAT, V63, P1026, DOI 10.1001/archpsyc.63.9.1026 Reichman NE, 2006, AM J PUBLIC HEALTH, V96, P862, DOI 10.2105/AJPH.2005.066324 Saha S, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000040 SARTORIUS GA, 2009, HUMAN REPROD UPDATE, P65 Sunderam Saswati, 2009, Morbidity and Mortality Weekly Report, V58, P1 Tucker KL, 1996, GENE DEV, V10, P1008, DOI 10.1101/gad.10.8.1008 Wing L, 2002, MENT RETARD DEV D R, V8, P151, DOI 10.1002/mrdd.10029 World Health Organization (WHO), 1994, INT CLASS DIS 10 REV Wright Victoria Clay, 2008, Morbidity and Mortality Weekly Report, V57, P1 NR 36 TC 58 Z9 61 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD FEB PY 2010 VL 3 IS 1 BP 30 EP 39 DI 10.1002/aur.116 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 565MH UT WOS:000275296800004 PM 20143326 ER PT J AU Jacob, S Landeros-Weisenberger, A Leckman, JF AF Jacob, Suma Landeros-Weisenberger, Angeli Leckman, James F. TI Autism Spectrum and Obsessive-Compulsive Disorders: OC Behaviors, Phenotypes and Genetics SO AUTISM RESEARCH LA English DT Review ID SEROTONIN TRANSPORTER GENE; FAMILY-BASED ASSOCIATION; PRADER-WILLI-SYNDROME; HIGH-FUNCTIONING AUTISM; FRAGILE-X PREMUTATION; PERVASIVE DEVELOPMENTAL DISORDERS; GENOME-WIDE LINKAGE; OF-THE-LITERATURE; CHROMOSOME 15Q11-Q13; TRANSMISSION DISEQUILIBRIUM AB Autism spectrum disorders (ASDs) are a phenotypically and etiologically heterogeneous set of disorders that include obsessive-compulsive behaviors (OCB) that partially overlap with symptoms associated with obsessive-compulsive disorder (OCD). The OCB seen in ASD vary depending on the individual's mental and chronological age as well as the etiology of their ASD. Although progress has been made in the measurement of the OCB associated with ASD, more work is needed including the potential identification of heritable endophenotypes. Likewise, important progress toward the understanding of genetic influences in ASD has been made by greater refinement of relevant phenotypes using a broad range of study designs, including twin and family-genetic studies, parametric and nonparametric linkage analyses, as well as candidate gene studies and the study of rare genetic variants. These genetic analyses could lead to the refinement of the OCB phenotypes as larger samples are studied and specific associations are replicated. Like ASID, OCB are likely to prove to be multidimensional and polygenic. Some of the vulnerability genes may prove to be generalist genes influencing the phenotypic expression of both ASD and OCD while others will be specific to subcomponents of the ASD phenotype. In order to discover molecular and genetic mechanisms, collaborative approaches need to generate shared samples, resources, novel genomic technologies, as well as more refined phenotypes and innovative statistical approaches. There is a growing need to identify the range of molecular pathways involved in OCB related to ASD in order to develop novel treatment interventions. C1 [Jacob, Suma] Univ Illinois, Inst Juvenile Res, Dept Psychiat, Chicago, IL 60612 USA. [Landeros-Weisenberger, Angeli; Leckman, James F.] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06510 USA. [Leckman, James F.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA. [Leckman, James F.] Yale Univ, Sch Med, Dept Psychol, New Haven, CT 06510 USA. [Leckman, James F.] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA. RP Jacob, S (reprint author), Univ Illinois, Inst Juvenile Res, Dept Psychiat, MC 747,1747 W Roosevelt Rd, Chicago, IL 60612 USA. EM sjacob@psych.uic.edu FU National Institutes of Health [K23MH082121]; NARSAD [T32 MH 19126, K05MH076273] FX Grant sponsor: National Institutes of Health; Grant numbers: K23MH082121; NARSAD Young Investigator Award; T32 MH 19126; K05MH076273. CR Abrahams BS, 2008, NAT REV GENET, V9, P341, DOI 10.1038/nrg2346 Alarcon M, 2002, AM J HUM GENET, V70, P60, DOI 10.1086/338241 Alcais A, 1999, GENET EPIDEMIOL, V17, P102, DOI 10.1002/(SICI)1098-2272(1999)17:2<102::AID-GEPI2>3.0.CO;2-6 Aoyama K, 2006, NAT NEUROSCI, V9, P119, DOI 10.1038/nn1609 Arnold PD, 2006, ARCH GEN PSYCHIAT, V63, P769, DOI 10.1001/archpsyc.63.7.769 Aziz M, 2003, AM J MED GENET B, V121B, P119, DOI 10.1002/ajmg.b.20030 BAILEY A, 1995, PSYCHOL MED, V25, P63 Bejerot S, 2001, NORD J PSYCHIAT, V55, P169 BELEROT S, 2007, AUTISM, V11, P101 Bengel D, 1999, MOL PSYCHIATR, V4, P463, DOI 10.1038/sj.mp.4000550 Berument SK, 1999, BRIT J PSYCHIAT, V175, P444, DOI 10.1192/bjp.175.5.444 Bhattacharyya Sagnik, 2007, Recent Pat CNS Drug Discov, V2, P47, DOI 10.2174/157488907779561727 Bloch MH, 2008, AM J PSYCHIAT, V165, P1532, DOI 10.1176/appi.ajp.2008.08020320 Bloch MH, 2008, AM J MED GENET B, V147B, P850, DOI 10.1002/ajmg.b.30699 Bodfish JW, 2000, J AUTISM DEV DISORD, V30, P237, DOI 10.1023/A:1005596502855 BOLTON P, 1994, J CHILD PSYCHOL PSYC, V35, P877, DOI 10.1111/j.1469-7610.1994.tb02300.x Bolton PF, 1998, PSYCHOL MED, V28, P385, DOI 10.1017/S0033291797006004 Brune CW, 2006, AM J PSYCHIAT, V163, P2148, DOI 10.1176/appi.ajp.163.12.2148 Buxbaum JD, 2002, MOL PSYCHIATR, V7, P311, DOI 10.1038/sj/mp/4001011 Buxbaum JD, 2004, MOL PSYCHIATR, V9, P144, DOI 10.1038/sj.mp.4001465 Camarena B, 2001, INT J NEUROPSYCHOPH, V4, P269 CATH DC, 2008, PSYCHOPATHOLOGY, V41, P104 Cavallini MC, 1999, AM J MED GENET, V88, P38, DOI 10.1002/(SICI)1096-8628(19990205)88:1<38::AID-AJMG7>3.0.CO;2-# Chabane N, 2004, NEUROSCI LETT, V363, P154, DOI 10.1016/j.neulet.2004.03.065 Chamberlain SR, 2008, SCIENCE, V321, P421, DOI 10.1126/science.1154433 Charman T, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P325 Cook EH, 2008, NATURE, V455, P919, DOI 10.1038/nature07458 Cook EH, 1997, MOL PSYCHIATR, V2, P247 Coon H, 2005, AM J MED GENET B, V135B, P42, DOI 10.1002/ajmg.b.30168 Crawley JN, 2007, BRAIN PATHOL, V17, P448, DOI 10.1111/j.1750-3639.2007.00096.x Cuccaro ML, 2007, CHILD PSYCHIAT HUM D, V37, P347, DOI 10.1007/s10578-006-0052-y Cullen B, 2008, PSYCHOPATHOLOGY, V41, P194, DOI 10.1159/000120988 Curran S, 2005, AM J MED GENET B, V137B, P25, DOI 10.1002/ajmg.b.30126 Delorme R, 2007, EUR PSYCHIAT, V22, P32, DOI 10.1016/j.eurpsy.2006.05.002 Delorme R, 2004, NEUROREPORT, V15, P699, DOI 10.1097/01.wnr.000011644797607dc Devlin B, 2005, MOL PSYCHIATR, V10, P1110, DOI 10.1038/sj.mp.4001724 Di Bella D., 2002, Pharmacogenomics Journal, V2, P176, DOI 10.1038/sj.tpj.6500090 Dickel DE, 2007, BIOL PSYCHIAT, V61, P322, DOI 10.1016/j.biopsych.2006.09.030 DORN MB, 1994, J AM ACAD CHILD PSY, V33, P256, DOI 10.1097/00004583-199402000-00015 Dutta S, 2007, CELL MOL NEUROBIOL, V27, P1035, DOI 10.1007/s10571-007-9193-6 Dykens EM, 2008, J CHILD PSYCHOL PSYC, V49, P1001, DOI 10.1111/j.1469-7610.2008.01913.x Dykens EM, 1996, J AM ACAD CHILD PSY, V35, P223, DOI 10.1097/00004583-199602000-00016 El Abd S, 1999, AM J MED GENET, V88, P510 Esbensen AJ, 2009, J AUTISM DEV DISORD, V39, P57, DOI 10.1007/s10803-008-0599-x Evans DW, 2000, CHILD DEV, V71, P288, DOI 10.1111/1467-8624.00144 Evans DW, 1997, CHILD DEV, V68, P58, DOI 10.2307/1131925 FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559 Fontenelle LF, 2004, PSYCHOPATHOLOGY, V37, P105, DOI 10.1159/000078608 Frazier TW, 2008, J AUTISM DEV DISORD, V38, P474, DOI 10.1007/s10803-007-0415-z Freitag CM, 2007, MOL PSYCHIATR, V12, P2, DOI 10.1038/sj.mp.4001896 Frisch A, 2000, EUR NEUROPSYCHOPHARM, V10, P205, DOI 10.1016/S0924-977X(00)00071-7 Gecz J, 2000, ANN HUM GENET, V64, P95, DOI 10.1046/j.1469-1809.2000.6420095.x Gesell A., 1943, INFANT CHILD CULTURE Gesell A., 1928, INFANCY HUMAN GROWTH Glessner JT, 2009, NATURE, V459, P569, DOI 10.1038/nature07953 Goddard AW, 2008, DRUG DISCOV TODAY, V13, P325, DOI 10.1016/j.drudis.2007.12.009 Goodlin-Jones BL, 2004, J DEV BEHAV PEDIATR, V25, P392, DOI 10.1097/00004703-200412000-00002 GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006 GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1012 Goos LM, 2008, ADV EXP MED BIOL, V626, P71 Greaves N, 2006, J INTELL DISABIL RES, V50, P92, DOI 10.1111/j.1365-2788.2005.00726.x Gu C, 1998, GENET EPIDEMIOL, V15, P609, DOI 10.1002/(SICI)1098-2272(1998)15:6<609::AID-GEPI5>3.0.CO;2-N Gupta AR, 2007, BIOL PSYCHIAT, V61, P429, DOI 10.1016/j.biopsych.2006.06.020 Gurdon JB, 2008, SCIENCE, V322, P1811, DOI 10.1126/science.1160810 Hagerman RJ, 2002, CURR OPIN GENET DEV, V12, P278, DOI 10.1016/S0959-437X(02)00299-X Hanna GL, 2002, AM J MED GENET, V114, P541, DOI 10.1002/ajmg.10519 Hendriksen JGM, 2008, J CHILD NEUROL, V23, P477, DOI 10.1177/0883073807309775 Hessl D, 2005, AM J MED GENET B, V139B, P115, DOI 10.1002/ajmg.b.30241 Hoeffer CA, 2008, NEURON, V60, P832, DOI 10.1016/j.neuron.2008.09.037 Hollander E, 2003, PSYCHIAT RES, V117, P11, DOI 10.1016/S0165-1781(02)00304-9 Hu VW, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-118 Ivarsson T, 2008, J ANXIETY DISORD, V22, P969, DOI 10.1016/j.janxdis.2007.10.003 Jamain S, 2002, MOL PSYCHIATR, V7, P302, DOI 10.1038/sj/mp/4000979 Kim SA, 2007, NEUROSCI RES, V58, P332, DOI 10.1016/j.neures.2007.03.002 Kim SJ, 2005, NEUROPSYCHOBIOLOGY, V52, P176, DOI 10.1159/000088860 Kim SJ, 2008, AM J MED GENET B, V147B, P1116, DOI 10.1002/ajmg.b.30733 Klauck SM, 1997, HUM MOL GENET, V6, P2233, DOI 10.1093/hmg/6.13.2233 Kolevzon A, 2004, AM J MED GENET B, V129B, P76, DOI 10.1002/ajmg.b.30011 LACHIEWICZ AM, 1992, AM J MED GENET, V43, P72, DOI 10.1002/ajmg.1320430111 Lam KSL, 2008, J CHILD PSYCHOL PSYC, V49, P1193, DOI 10.1111/j.1469-7610.2008.01944.x Lesch KP, 1996, SCIENCE, V274, P1527, DOI 10.1126/science.274.5292.1527 LESCH KP, 1994, J NEURAL TRANSM-GEN, V95, P157, DOI 10.1007/BF01276434 Lewis MH, 2007, BEHAV BRAIN RES, V176, P66, DOI 10.1016/j.bbr.2006.08.023 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Maestrini E, 1999, AM J MED GENET, V88, P492, DOI 10.1002/(SICI)1096-8628(19991015)88:5<492::AID-AJMG11>3.0.CO;2-X Makeyev EV, 2008, SCIENCE, V319, P1789, DOI 10.1126/science.1152326 Mandy WPL, 2008, J CHILD PSYCHOL PSYC, V49, P795, DOI 10.1111/j.1469-7610.2008.01911.x Marshall CR, 2008, AM J HUM GENET, V82, P477, DOI 10.1016/j.ajhg.2007.12.009 Martin ER, 2000, AM J MED GENET, V96, P43, DOI 10.1002/(SICI)1096-8628(20000207)96:1<43::AID-AJMG9>3.0.CO;2-3 Mataix-Cols D, 2005, AM J PSYCHIAT, V162, P228, DOI 10.1176/appi.ajp.162.2.228 McCauley JL, 2004, AM J MED GENET B, V131B, P51, DOI 10.1002/ajmg.b.30038 McDougle CJ, 1998, MOL PSYCHIATR, V3, P270, DOI 10.1038/sj.mp.4000391 MCDOUGLE CJ, 1995, AM J PSYCHIAT, V152, P772 Milner KM, 2005, J CHILD PSYCHOL PSYC, V46, P1089, DOI 10.1111/j.1469-7610.2005.01520.x Minshawi NF, 2008, CHILD ADOL PSYCH CL, V17, P875, DOI 10.1016/j.chc.2008.06.012 Moore CJ, 2004, NEUROPSYCHOLOGIA, V42, P1934, DOI 10.1016/j.neuropsycholgia.2004.05.002 Mossner R, 2006, INT J NEUROPSYCHOPH, V9, P437, DOI 10.1017/S1461145705005997 Moy SS, 2008, MOL PSYCHIATR, V13, P4, DOI 10.1038/sj.mp.4002082 Moy SS, 2008, BEHAV BRAIN RES, V188, P178, DOI 10.1016/j.bbr.2007.10.029 Mulder EJ, 2005, AM J MED GENET B, V133B, P93, DOI 10.1002/ajmg.b.30122 Nakamine A, 2008, AM J MED GENET A, V146A, P636, DOI 10.1002/ajmg.a.31636 Ozaki N, 2003, MOL PSYCHIATR, V8, P933, DOI 10.1038/sj.mp.4001365 Pardo CA, 2007, BRAIN PATHOL, V17, P434, DOI 10.1111/j.1750-3639.2007.00102.x Pauls DL, 2008, AM J MED GENET C, V148C, P133, DOI 10.1002/ajmg.c.30168 Philippe A, 1999, HUM MOL GENET, V8, P805, DOI 10.1093/hmg/8.5.805 Pine DS, 2008, J AM ACAD CHILD PSY, V47, P652, DOI 10.1097/CHI.0b013e31816bffa5 Pittenger C, 2008, J CLIN PSYCHOPHARM, V28, P363, DOI 10.1097/JCP.0b013e3181727548 Piven J, 1997, AM J PSYCHIAT, V154, P185 Potocki L, 2000, NAT GENET, V24, P84 Prado HD, 2008, CNS SPECTRUMS, V13, P425 Prasad HC, 2005, P NATL ACAD SCI USA, V102, P11545, DOI 10.1073/pnas.0501432102 Purcell AE, 2001, NEUROLOGY, V57, P1618 Ramoz N, 2006, AM J MED GENET B, V141B, P861, DOI 10.1002/ajmg.b.30356 Ronald A, 2005, DEVELOPMENTAL SCI, V8, P444, DOI 10.1111/j.1467-7687.2005.00433.x Ronald A, 2006, J AM ACAD CHILD PSY, V45, P691, DOI 10.1097/01.chi.0000215325.13058.9d Ronald A, 2006, SOC NEUROSCI-UK, V1, P412, DOI 10.1080/17470910601068088 Rosario-Campos MC, 2006, MOL PSYCHIATR, V11, P495, DOI 10.1038/sj.mp.4001798 Russell AJ, 2005, BRIT J PSYCHIAT, V186, P525, DOI 10.1192/bjp.186.6.525 Sacco R, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-11 Salmon B, 1999, AM J MED GENET, V88, P551, DOI 10.1002/(SICI)1096-8628(19991015)88:5<551::AID-AJMG21>3.0.CO;2-# Scahill L, 1997, J AM ACAD CHILD PSY, V36, P844, DOI 10.1097/00004583-199706000-00023 Scahill L, 2006, J AM ACAD CHILD PSY, V45, P1114, DOI 10.1097/01.chi.0000220854.79144.e7 Dimitropoulos Anastasia, 2007, Curr Psychiatry Rep, V9, P159 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 Shao YJ, 2003, AM J HUM GENET, V72, P539, DOI 10.1086/367846 Shuang M, 2004, AM J MED GENET B, V131B, P48, DOI 10.1002/ajmg.b.30025 Silverman JM, 2002, AM J MED GENET, V114, P64, DOI 10.1002/ajmg.10048 Stewart SE, 2007, AM J MED GENET B, V144B, P1027, DOI 10.1002/ajmg.b.30533 Stone JL, 2004, AM J HUM GENET, V75, P1117, DOI 10.1086/426034 Sutcliffe JS, 2005, AM J HUM GENET, V77, P265, DOI 10.1086/432648 Symons FJ, 2005, J INTELL DISABIL RES, V49, P144, DOI 10.1111/j.1365-2788.2004.00632.x Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 Tassone F, 2000, AM J MED GENET, V97, P195, DOI 10.1002/1096-8628(200023)97:3<195::AID-AJMG1037>3.0.CO;2-R Telvi L, 1999, PEDIATRICS, V104, P304, DOI 10.1542/peds.104.2.304 Tochigi M, 2007, J HUM GENET, V52, P985, DOI 10.1007/s10038-007-0207-5 Veenstra-VanderWeele J, 2004, MOL PSYCHIATR, V9, P819, DOI 10.1038/sj.mp.4001505 Walitza S, 2004, J NEURAL TRANSM, V111, P817, DOI 10.1007/s00702-004-0134-y Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Wang L, 2009, BEHAV PHARMACOL, V20, P119, DOI 10.1097/FBP.0b013e32832a80ad [王让定 Wang Rngding], 2003, [计算机工程, Computer Engineering], V29, P31 Weiss LA, 2009, NATURE, V461, P802, DOI 10.1038/nature08490 Welch JM, 2007, NATURE, V448, P894, DOI 10.1038/nature06104 Wendland JR, 2008, PSYCHIAT GENET, V18, P31, DOI 10.1097/YPG.0b013e3282f08a06 Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4 Wilcox J, 2003, NEUROPSYCHOBIOLOGY, V47, P171, DOI 10.1159/000071210 Williams DL, 2008, RES AUTISM SPECT DIS, V2, P353, DOI 10.1016/j.rasd.2007.08.005 Willour VL, 2004, AM J HUM GENET, V75, P508, DOI 10.1086/423899 Yrigollen CM, 2008, BIOL PSYCHIAT, V63, P911, DOI 10.1016/j.biopsych.2007.11.015 Zai G, 2005, AM J MED GENET B, V134B, P25, DOI 10.1002/ajmg.30452 Zarcone J, 2007, J INTELL DISABIL RES, V51, P478, DOI 10.1111/j.1365-2788.2006.00916.x Zhang HP, 1996, AM J HUM GENET, V59, P951 Zhao X, 2007, P NATL ACAD SCI USA, V104, P12831, DOI 10.1073/pnas.0705803104 Zhao XY, 2007, EPIGENETICS, V2, P126 Zohar AH, 2001, J ABNORM CHILD PSYCH, V29, P121, DOI 10.1023/A:1005231912747 Zuchner S, 2009, MOL PSYCHIATR, V14, P6, DOI 10.1038/mp.2008.83 NR 156 TC 22 Z9 22 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2009 VL 2 IS 6 BP 293 EP 311 DI 10.1002/aur.108 PG 19 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 546II UT WOS:000273804100001 PM 20029829 ER PT J AU DeVincent, CJ Gadow, KD AF DeVincent, Carla J. Gadow, Kenneth D. TI Relative Clinical Utility of Three Child Symptom Inventory-4 Scoring Algorithms for Differentiating Children With Autism Spectrum Disorder vs. Attention-Deficit Hyperactivity Disorder SO AUTISM RESEARCH LA English DT Article DE autism spectrum disorder; Child Symptom Inventory-4; autism; Asperger's syndrome; PDD-NOS; pervasive developmental disorder ID PERVASIVE DEVELOPMENTAL DISORDER; DSM-IV; DEFICIT/HYPERACTIVITY DISORDER; DIAGNOSTIC INTERVIEW; MULTIPLE INFORMANTS; TIC DISORDER; ADHD; POPULATION; SAMPLE; PDD AB Objective: The present study compared three separate Child Symptom Inventory-4 (CSI-4) scoring algorithms for differentiating children with autism spectrum disorder (ASD) from youngsters with attention-deficit/hyperactivity disorder (ADHD). Method: Parents/teachers completed the CSI-4, a DSM-IV-referenced rating scale, for 6 to 12-year-old clinical referrals with ASD (N = 186) and ADHD (N = 251). Algorithms were based on either all CSI-4 items (forward logistic regressions) or the 12 DSM-IV symptoms of pervasive developmental disorder (PDD) included in the CSI-4. Results: ROC analyses indicated generally good to excellent values for area under the curve, sensitivity, specificity, and positive predictive power. Algorithms for parent ratings were superior to teacher ratings. The algorithm based solely on PDD symptoms evidenced the greatest generalizability. Conclusion: Although algorithms generated from regression analyses produced greater clinical utility for specific samples, the PDD-based algorithm resulted in greater stability across samples. C1 [Gadow, Kenneth D.] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA. [DeVincent, Carla J.] SUNY Stony Brook, Dept Pediat, Cody Ctr Autism & Dev Disabil, Stony Brook, NY 11794 USA. RP Gadow, KD (reprint author), SUNY Stony Brook, Dept Psychiat, Putnam Hall,South Campus, Stony Brook, NY 11794 USA. EM kenneth.gadow@stonybrook.edu FU The Matt and Debra Cody Center for Autism and Developmental Disorders FX Grant sponsor: The Matt and Debra Cody Center for Autism and Developmental Disorders. CR ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213 BIRD HR, 1992, J AM ACAD CHILD PSY, V31, P78, DOI 10.1097/00004583-199201000-00012 Cicchetti DV, 1995, CHILD NEUROPSYCHOL, V1, P26, DOI 10.1080/09297049508401340 Conners C. K., 1973, PSYCHOPHARMACOLOGY B, V9, P24 Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524 DeVincent C, 2008, J DEV BEHAV PEDIATR, V29, P1, DOI 10.1097/DBP.0b013e3181468c32 Fombonne E, 2005, J CLIN PSYCHIAT, V66, P3 FRICK PJ, 1994, J AM ACAD CHILD PSY, V33, P529, DOI 10.1097/00004583-199405000-00011 Gadow K. D., 2002, CHILD SYMPTOM INVENT Gadow K. D., 1997, CHILD SYMPTOM INVENT Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x Gadow KD, 2005, AUTISM, V9, P392, DOI 10.1177/1362361305056079 Gadow KD, 2005, J CHILD NEUROL, V20, P481, DOI 10.1177/08830738050200060301 Gadow KD, 2009, J ATTEN DISORD, V12, P474, DOI 10.1177/1087054708320404 Gadow KD, 2008, J AUTISM DEV DISORD, V38, P1302, DOI 10.1007/s10803-007-0516-8 Gadow KD, 2007, J AM ACAD CHILD PSY, V46, P840, DOI 10.1097/chi.0b013e31805c0860 Gadow KD, 1986, STONY BROOK CHILD PS Gadow KD, 2006, J AUTISM DEV DISORD, V36, P271, DOI 10.1007/s10803-005-0060-3 GADOW KD, 2008, SYMPTOM INVENTORIES Gadow KD, 2008, J AUTISM DEV DISORD, V38, P419, DOI 10.1007/s10803-007-0408-y Geurts HM, 2008, NEUROPSYCHOLOGIA, V46, P3030, DOI 10.1016/j.neuropsychologia.2008.06.013 Goldstein S, 2004, J AUTISM DEV DISORD, V34, P329, DOI 10.1023/B:JADD.0000029554.46570.68 GOYETTE CH, 1978, J ABNORM CHILD PSYCH, V6, P221, DOI 10.1007/BF00919127 Happe F, 2008, NEUROPSYCHOL REV, V18, P287, DOI 10.1007/s11065-008-9076-8 Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA Lecavalier L, 2009, J CHILD PSYCHOL PSYC, V50, P1246, DOI 10.1111/j.1469-7610.2009.02104.x Lecavalier L, 2009, J AUTISM DEV DISORD, V39, P278, DOI 10.1007/s10803-008-0622-2 Lee DO, 2006, J CHILD ADOL PSYCHOP, V16, P737, DOI 10.1089/cap.2006.16.737 Loney J., 1982, ADV DEV BEHAVIORAL P, V3, P113 LONEY J, 1984, ANN M AM PSYCH ASS T Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Newschaffer CJ, 2005, PEDIATRICS, V115, pE277, DOI 10.1542/peds.2004-1958 Offord DR, 1996, J AM ACAD CHILD PSY, V35, P1078, DOI 10.1097/00004583-199608000-00019 Pierre CB, 1999, J DEV BEHAV PEDIATR, V20, P170 Posserud MB, 2006, J CHILD PSYCHOL PSYC, V47, P167, DOI 10.1111/j.1469-7610.2005.01462.x Reich W, 2000, J AM ACAD CHILD PSY, V39, P59, DOI 10.1097/00004583-200001000-00017 Reiersen AM, 2008, J AM ACAD CHILD PSY, V47, P662, DOI 10.1097/CHI.0b013e31816bff88 Ronald A, 2008, EUR CHILD ADOLES PSY, V17, P473, DOI 10.1007/s00787-008-0689-5 Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x RUTTER M, 1967, BRIT J PSYCHIAT, V113, P1183, DOI 10.1192/bjp.113.504.1183 Simonoff E, 2008, J AM ACAD CHILD PSY, V47, P921, DOI 10.1097/CHI.0b013e318179964f Smalley SL, 2002, AM J HUM GENET, V71, P959, DOI 10.1086/342732 Snow AV, 2009, J CHILD PSYCHOL PSYC, V50, P734, DOI 10.1111/j.1469-7610.2008.02018.x Sverd Jeffrey, 2003, J Psychiatr Pract, V9, P111, DOI 10.1097/00131746-200303000-00003 SZATMARI P, 1994, J AUTISM DEV DISORD, V24, P703, DOI 10.1007/BF02172281 White SW, 2009, CLIN PSYCHOL REV, V29, P216, DOI 10.1016/j.cpr.2009.01.003 Wiggins LD, 2006, J DEV BEHAV PEDIATR, V27, pS79, DOI 10.1097/00004703-200604002-00005 Witwer AN, 2008, J AUTISM DEV DISORD, V38, P1611, DOI 10.1007/s10803-008-0541-2 Yoshida Y, 2004, EUR CHILD ADOLES PSY, V13, P307, DOI 10.1007/s00787-004-0391-1 NR 49 TC 14 Z9 14 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2009 VL 2 IS 6 BP 312 EP 321 DI 10.1002/aur.106 PG 10 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 546II UT WOS:000273804100002 PM 20014095 ER PT J AU Yerys, BE Wallace, GL Sokoloff, JL Shook, DA James, JD Kenworthy, L AF Yerys, Benjamin E. Wallace, Gregory L. Sokoloff, Jennifer L. Shook, Devon A. James, Joette D. Kenworthy, Lauren TI Attention Deficit/Hyperactivity Disorder Symptoms Moderate Cognition and Behavior in Children With Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE clinical psychology; neuropsychology; school age < pediatrics; psychopathology ID DEFICIT-HYPERACTIVITY DISORDER; PERVASIVE DEVELOPMENTAL DISORDERS; DIAGNOSTIC OBSERVATION SCHEDULE; HIGHER FUNCTIONING INDIVIDUALS; RECIPROCAL SOCIAL-BEHAVIOR; EXECUTIVE FUNCTION; COMMUNICATION ABILITIES; ADAPTIVE SKILLS; TWIN SAMPLE; ADHD AB Recent estimates suggest that 31% of children with autism spectrum disorders (ASD) meet diagnostic criteria for attention deficit/hyperactivity disorder (ADHD), and another 24% of children with ASD exhibit subthreshold clinical ADHD symptoms. Presence of ADHD symptoms in the context of ASD could have a variety of effects on cognition, autistic traits, and adaptive/maladaptive behaviors including: exacerbating core ASD impairments; adding unique impairments specific to ADHD; producing new problems unreported in ASD or ADHD; having no clear impact; or producing some combination of these scenarios. Children with ASD and co-morbid ADHD symptoms (ASD+ADHD; n = 21), children with ASD without ADHD (ASD; n = 28), and a typically developing control group (n = 21) were included in the study; all groups were matched on age, gender-ratio, 10, and socioeconomic status. Data were collected on verbal and spatial working memory, response inhibition, global executive control (EC), autistic traits, adaptive functioning, and maladaptive behavior problems. In this sample, the presence of ADHD symptoms in ASD exacerbated impairments in EC and adaptive behavior and resulted in higher autistic trait, and externalizing behavior ratings. ADHD symptoms were also associated with greater impairments on a lab measure of verbal working memory. These findings suggest that children with ASD+ADHD symptoms present with exacerbated impairments in some but not all domains of functioning relative to children with ASD, most notably in adaptive behavior and working memory. Therefore, ADHD may moderate the expression of components of the ASD cognitive and behavioral phenotype, but ASD+ADHD may not represent an etiologically distinct phenotype from ASD alone. C1 [Yerys, Benjamin E.; Sokoloff, Jennifer L.; James, Joette D.; Kenworthy, Lauren] Childrens Natl Med Ctr, Childrens Res Inst Neurosci, Washington, DC 20010 USA. [Yerys, Benjamin E.; Sokoloff, Jennifer L.; James, Joette D.; Kenworthy, Lauren] Childrens Natl Med Ctr, Ctr Autism Spectrum Disorders, Washington, DC 20010 USA. [Wallace, Gregory L.] NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA. [Shook, Devon A.] Georgetown Univ, Dept Psychol, Washington, DC 20057 USA. RP Yerys, BE (reprint author), Childrens Natl Med Ctr, Childrens Res Inst Neurosci, 111 Michigan Ave NW, Washington, DC 20010 USA. EM byers@cnmc.org FU Frederick and Elizabeth Singer Foundation; NIH [IDDRC P30HD40677, NIH T32HD046388]; National Institute of Mental Health Intramural Research Program [U54 MH066417]; Studies for the Advancement of Autism Research and Treatment; Intellectual and Developmental Disabilities Research Center at Children's National Medical Center; General Clinic Research Center [NIH GCRC M01-RR13297] FX Grant sponsors: Frederick and Elizabeth Singer Foundation; NIH; National Institute of Mental Health Intramural Research Program; Studies for the Advancement of Autism Research and Treatment; Grant number: NIMH U54 MH066417; Grant sponsor: Intellectual and Developmental Disabilities Research Center at Children's National Medical Center; Grant numbers: NIH IDDRC P30HD40677; NIH T32HD046388; Grant sponsor: General Clinic Research Center; Grant number: NIH GCRC M01-RR13297. CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT BARKLEY RA, 1990, J CONSULT CLIN PSYCH, V58, P775, DOI 10.1037//0022-006X.58.6.775 BENJAMINI Y, 1995, J ROY STAT SOC B MET, V57, P289 Bishop DVM, 2005, AUTISM, V9, P29, DOI 10.1177/1362361305049028 Bradshaw EJ, 2006, SPORT BIOMECH, V5, P1 Brieber S, 2007, J CHILD PSYCHOL PSYC, V48, P1251, DOI 10.1111/j.1469-7610.2007.01799.x Cambridge-Cognition, 1996, CANTAB Carter AS, 1998, J AUTISM DEV DISORD, V28, P287, DOI 10.1023/A:1026056518470 Clark T, 1999, EUR CHILD ADOLES PSY, V8, P50 Constantino JN, 2004, J CHILD PSYCHOL PSYC, V45, P719, DOI 10.1111/j.1469-7610.2004.00266.x Constantino JN, 2003, J AM ACAD CHILD PSY, V42, P458, DOI 10.1097/01.CHI.0000046811.95464.21 Constantino JN, 2000, J DEV BEHAV PEDIATR, V21, P2 Constantino JN, 2005, SOCIAL RESPONSIVENES Corbett BA, 2009, PSYCHIAT RES, V166, P210, DOI 10.1016/j.psychres.2008.02.005 Didden R, 2008, J INTELL DISABIL RES, V52, P503, DOI 10.1111/j.1365-2788.2008.01055.x DuPaul GJ, 1998, ADHD RATING SCALE 4 Durston S, 2003, BIOL PSYCHIAT, V53, P871, DOI 10.1016/S0006-3223(02)01904-2 Gadow KD, 2008, J CHILD PSYCHOL PSYC, V49, P1331, DOI 10.1111/j.1469-7610.2008.01952.x Geurts HM, 2008, J CHILD PSYCHOL PSYC, V49, P848, DOI 10.1111/j.1469-7610.2008.01916.x Geurts HM, 2009, TRENDS COGN SCI, V13, P74, DOI 10.1016/j.tics.2008.11.006 Geurts HM, 2004, J CHILD PSYCHOL PSYC, V45, P836, DOI 10.1111/j.1469-7610.2004.00276.x Gilotty L, 2002, CHILD NEUROPSYCHOL, V8, P241, DOI 10.1076/chin.8.4.241.13504 Gioia GA, 2000, BEHAV RATING INVENTO Gioia GA, 2002, CHILD NEUROPSYCHOL, V8, P121 GIOIA GA, 2001, CLIN NEUROPSYCHOL, V2, P61 Goldberg MC, 2005, J AUTISM DEV DISORD, V35, P279, DOI 10.1007/s10803-005-3291-4 GORAMUS HK, 2009, CLIN NEUROPSYCHOLOGY, V120, P60 Gotham K, 2007, J AUTISM DEV DISORD, V37, P613, DOI 10.1007/s10803-006-0280-1 Green V. A., 2006, FOCUS AUTISM OTHER D, V21, P230, DOI [10.1177/10883576060210040401, DOI 10.1177/10883576060210040401] Happe F, 2006, BRAIN COGNITION, V61, P25, DOI 10.1016/j.bandc.2006.03.004 Hartley SL, 2009, J AUTISM DEV DISORD, V39, P1715, DOI 10.1007/s10803-009-0810-8 Hill EL, 2004, TRENDS COGN SCI, V8, P26, DOI 10.1016/j.tics.2003.11.003 Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA Hudziak JJ, 2004, J CHILD PSYCHOL PSYC, V45, P1299, DOI 10.1111/j.1469-7610.2004.00314.x Johnson KA, 2007, NEUROPSYCHOLOGIA, V45, P2234, DOI 10.1016/j.neuropsychologia.2007.02.019 Kenworthy L, 2008, NEUROPSYCHOL REV, V18, P320, DOI 10.1007/s11065-008-9077-7 KENWORTHY L, 2009, CHILD NEUROPSYCHOL, V15, P225, DOI DOI 10.1080/09297040802646983 Kenworthy LE, 2005, DEV NEUROPSYCHOL, V28, P809, DOI 10.1207/s15326942dn2803_4 Klin A, 2007, J AUTISM DEV DISORD, V37, P748, DOI 10.1007/s10803-006-0229-4 Lahey BB, 2004, AM J PSYCHIAT, V161, P2014, DOI 10.1176/appi.ajp.161.11.2014 Lainhart JE, 2006, AM J MED GENET A, V140A, P2257, DOI 10.1002/ajmg.a.31465 LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363 Leyfer OT, 2006, J AUTISM DEV DISORD, V36, P849, DOI 10.1007/s10803-006-0123-0 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Luteijn EEF, 1998, J AUTISM DEV DISORD, V28, P559, DOI 10.1023/A:1026060330122 Luteijn EF, 2000, EUR CHILD ADOLES PSY, V9, P168 Manly T., 1999, TEST EVERYDAY ATTENT Matsushima Noriaki, 2008, Osaka City Med J, V54, P1 Mundy PC, 2007, RES PRACT PERS SEV D, V32, P124 NEALE MC, 1995, AM J HUM GENET, V28, P83 Ogdie MN, 2003, AM J HUM GENET, V72, P1268, DOI 10.1086/375139 Ozonoff S, 1999, J AUTISM DEV DISORD, V29, P171, DOI 10.1023/A:1023052913110 Pennington B. F., 2002, DEV PSYCHOPATHOLOGY Peters-Scheffer N, 2008, RES DEV DISABIL, V29, P398, DOI 10.1016/j.ridd.2007.07.004 Reiersen AM, 2007, J CHILD PSYCHOL PSYC, V48, P464, DOI 10.1111/j.1469-7610.2006.01720.x Reynolds C. R., 1992, BEHAV ASSESSMENT SYS ROIZEN NJ, 1994, ARCH PEDIAT ADOL MED, V148, P1137 Ronald A, 2008, J CHILD PSYCHOL PSYC, V49, P535, DOI 10.1111/j.1469-7610.2007.01857.x Saulnier CA, 2007, J AUTISM DEV DISORD, V37, P788, DOI 10.1007/s10803-006-0288-6 Schmitz N, 2006, BIOL PSYCHIAT, V59, P7, DOI 10.1016/j.biopsych.2005.06.007 Sinzig J, 2008, ACTA NEUROPSYCHIATR, V20, P207, DOI 10.1111/j.1601-5215.2008.00292.x Sinzig Judith, 2008, Child Adolesc Psychiatry Ment Health, V2, P4, DOI 10.1186/1753-2000-2-4 Smalley SL, 2002, AM J HUM GENET, V71, P959, DOI 10.1086/342732 Sparrow S, 1984, VINELAND ADAPTIVE BE Stavro GM, 2007, J INT NEUROPSYCH SOC, V13, P324, DOI 10.1017/S1355617707070348 STEIN MA, 1995, J CHILD PSYCHOL PSYC, V36, P663, DOI 10.1111/j.1469-7610.1995.tb02320.x Sturm H, 2004, DEV MED CHILD NEUROL, V46, P444, DOI 10.1017/S0012162204000738 Tsuchiya E, 2005, BRAIN DEV-JPN, V27, P233, DOI 10.1016/j.braindev.2004.06.008 VOLKMAR FR, 1993, J AM ACAD CHILD PSY, V32, P627, DOI 10.1097/00004583-199305000-00020 VOLKMAR FR, 1987, J AM ACAD CHILD PSY, V26, P156, DOI 10.1097/00004583-198703000-00005 Wechsler D., 2003, WECHSLER SCALES INTE Wechsler D, 1999, WECHSLER ABBREVIATED Wechsler D., 1991, WECHSLER SCALES INTE Willcutt EG, 2005, BIOL PSYCHIAT, V57, P1336, DOI 10.1016/j.biopsych.2005.02.006 NR 75 TC 62 Z9 64 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2009 VL 2 IS 6 BP 322 EP 333 DI 10.1002/aur.103 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 546II UT WOS:000273804100003 PM 19998356 ER PT J AU Nadig, A Vivanti, G Ozonoff, S AF Nadig, Aparna Vivanti, Giacomo Ozonoff, Sally TI Adaptation of Object Descriptions to a Partner Under Increasing Communicative Demands: A Comparison of Children With and Without Autism SO AUTISM RESEARCH LA English DT Article DE social cognition; developmental psychology ID LANGUAGE IMPAIRMENT; REFERENTIAL COMMUNICATION; SPECTRUM DISORDERS; PERSPECTIVE-TAKING; MENTAL-RETARDATION; CATEGORIZATION; INDIVIDUALS; RESOLUTION; KNOWLEDGE; BELIEF AB This study compared the object descriptions of school-age children with high-functioning autism (HFA) with those of a matched group of typically developing children. Descriptions were elicited in a referential communication task where shared information was manipulated, and in a guessing game where clues had to be provided about the identity of an object that was hidden from the addressee. Across these tasks, increasingly complex levels of audience design were assessed: (1) the ability to give adequate descriptions from one's own perspective, (2) the ability to adjust descriptions to an addressee's perspective when this differs from one's own, and (3) the ability to provide indirect yet identifying descriptions in a situation where explicit labeling is inappropriate. Results showed that there were group differences in all three cases, with the HFA group giving less efficient descriptions with respect to the relevant context than the comparison group. More revealing was the identification of distinct adaptation profiles among the HFA participants: those who had difficulty with all three levels, those who displayed Level I audience design but poor Level 2 and Level 3 design, and those demonstrated all three levels of audience design, like the majority of the comparison group. Higher structural language ability, rather than symptom severity or social skills, differentiated those HFA participants with typical adaptation profiles from those who displayed deficient audience design, consistent with previous reports of language use in autism. C1 [Nadig, Aparna] McGill Univ, Sch Commun Sci & Disorders, Montreal, PQ H3G 1A8, Canada. RP Nadig, A (reprint author), McGill Univ, Sch Commun Sci & Disorders, 1266 Pine Ave W, Montreal, PQ H3G 1A8, Canada. EM aparna.nadig@mcgill.ca FU NRSA [NIDCD F32-DC007297] FX Grant sponsor: NRSA; Grant number: NIDCD F32-DC007297. CR Adams C, 2002, J CHILD PSYCHOL PSYC, V43, P679, DOI 10.1111/1469-7610.00056 Akhtar N, 1996, CHILD DEV, V67, P635, DOI 10.2307/1131837 Baron-Cohen S., 2000, UNDERSTANDING OTHER, P3 BARONCOHEN S, 1985, COGNITION, V21, P37, DOI 10.1016/0010-0277(85)90022-8 BISHOP DVM, 1991, APPL PSYCHOLINGUIST, V12, P199, DOI 10.1017/S0142716400009140 Bishop DVM, 2002, J CHILD PSYCHOL PSYC, V43, P917, DOI 10.1111/1469-7610.00114 Bloom P, 1996, COGNITION, V60, P1, DOI 10.1016/0010-0277(95)00699-0 Bloom P, 1998, COGNITION, V66, P87 Booth AE, 2002, DEV PSYCHOL, V38, P948, DOI 10.1037//0012-1649.38.6.948 Brock J, 2008, COGNITION, V108, P896, DOI 10.1016/j.cognition.2008.06.007 Capps L., 1998, AUTISM, V2, P325, DOI DOI 10.1177/1362361398024002 Clark H. H., 1981, ELEMENTS DISCOURSE U, P10 COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155 Dahlgren S, 2008, AUTISM, V12, P335, DOI 10.1177/1362361308091648 DAVIS AJ, 1976, J YOUTH ADOLESCENCE, V5, P187, DOI 10.1007/BF01537493 De Fosse L, 2004, ANN NEUROL, V56, P757, DOI 10.1002/ana.20275 Fisher N, 2005, J CHILD PSYCHOL PSYC, V46, P409, DOI 10.1111/j.1469-7610.2004.00371.x Frith U., 1994, SOCIAL DEV, V3, P108, DOI DOI 10.1111/J.1467-9507.1994.TB00031.X Grice H. P., 1975, SYNTAX SEMANTICS, P41, DOI DOI 10.1017/S0022226700005296 KAGEN J, 1963, MONOGRAPHS SOC RES C, V28, P73 Kjelgaard MM, 2001, LANG COGNITIVE PROC, V16, P287 KLIN A, 2003, PHILOS T ROYAL SOC B Klinger L. G., 1995, LEARNING COGNITION A, P119 Klinger LG, 2001, DEV PSYCHOPATHOL, V13, P111, DOI 10.1017/S0954579401001080 Lord C., 1999, AUTISM DIAGNOSTIC OB LOVELAND KA, 1989, APPL PSYCHOLINGUIST, V10, P301, DOI 10.1017/S014271640000864X Mervis CB, 2004, J AUTISM DEV DISORD, V34, P7, DOI 10.1023/B:JADD.0000018069.69562.b8 Minshew NJ, 2002, NEUROPSYCHOLOGY, V16, P327, DOI 10.1037//0894-4105.16.3.327 Nadig AS, 2002, PSYCHOL SCI, V13, P329, DOI 10.1111/1467-9280.00460 Nilsen ES, 2009, COGNITIVE PSYCHOL, V58, P220, DOI 10.1016/j.cogpsych.2008.07.002 Norbury CF, 2005, J EXP CHILD PSYCHOL, V90, P142, DOI 10.1016/j.jecp.2004.11.003 Norbury CF, 2002, INT J LANG COMM DIS, V37, P227, DOI 10.1080/13682820210136269 Norbury CF, 2003, INT J LANG COMM DIS, V38, P287, DOI 10.1080/136820310000108133 Norbury CF, 2004, J SPEECH LANG HEAR R, V47, P1179, DOI 10.1044/1092-4388(2004/87) NORBURY CF, 2009, J CHILD PSYCHOL PSYC OLVER RR, 1966, STUDIES COGNITIVE GR O'Neill DK, 2000, DEVELOPMENTAL SCI, V3, P457, DOI 10.1111/1467-7687.00139 ONeill DK, 1996, CHILD DEV, V67, P659, DOI 10.1111/j.1467-8624.1996.tb01758.x Ozonoff S, 2001, J AUTISM DEV DISORD, V31, P257, DOI 10.1023/A:1010794902139 PAUL R, 1984, APPL PSYCHOLINGUIST, V5, P349, DOI 10.1017/S0142716400005221 PERNER J, 1989, CHILD DEV, V60, P689, DOI 10.1111/j.1467-8624.1989.tb02749.x PETTS GE, 1986, CATENA, V13, P305, DOI 10.1016/0341-8162(86)90005-6 Ramberg C, 1996, EUR J DISORDER COMM, V31, P387 Rutter M., 2003, SOCIAL COMMUNICATION Semel E., 2003, CLIN EVALUATION LANG, V4th SHULMAN C, 1995, J ABNORM PSYCHOL, V104, P601, DOI 10.1037//0021-843X.104.4.601 SKEEN JA, 1983, INT J BEHAV DEV, V6, P213 Sparrow SS, 2005, VINELAND ADAPTIVE BE Tager-Flusberg H., 2005, HDB AUTISM PERVASIVE, P335 Trauble B, 2007, COGNITION, V105, P362, DOI 10.1016/j.cognition.2006.10.003 Volden J, 1997, APPL PSYCHOLINGUIST, V18, P181, DOI 10.1017/S0142716400009966 Walenski M., 2006, UNDERSTANDING AUTISM, P175 WESCHLER D, 1999, WESCHER ABBREVIATED Wetherby AM, 2007, J AUTISM DEV DISORD, V37, P960, DOI 10.1007/s10803-006-0237-4 NR 54 TC 6 Z9 6 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2009 VL 2 IS 6 BP 334 EP 347 DI 10.1002/aur.102 PG 14 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 546II UT WOS:000273804100004 PM 19998354 ER PT J AU Kuschner, ES Bodner, KE Minshew, NJ AF Kuschner, Emily S. Bodner, Kimberly E. Minshew, Nancy J. TI Local vs. Global Approaches to Reproducing the Rey Osterrieth Complex Figure By Children, Adolescents, and Adults With High-Functioning Autism SO AUTISM RESEARCH LA English DT Article DE autism; visual processing; visuo-spatial abilities; local processing; global processing; strategic planning; problem solving; neural connectivity ID WEAK CENTRAL COHERENCE; DIAGNOSTIC OBSERVATION SCHEDULE; SPATIAL WORKING-MEMORY; EXECUTIVE FUNCTION; SPECTRUM DISORDERS; DISEMBEDDING PERFORMANCE; SENTENCE COMPREHENSION; VISUOSPATIAL ANALYSIS; DEVELOPMENTAL-TRENDS; ASPERGERS-DISORDER AB Individuals with autism have an atypical pattern of visual processing. Various studies have provided evidence that individuals with autism perceive the details of stimuli before the gestalt, the reverse of the typical pattern of visual processing. This study used the Rey Osterreith Complex Figure (ROCF) task and an objective scoring system to examine local/global processing approaches to its reproduction in 37 individuals diagnosed with high-functioning autism (HFA) compared to 49 age-, IQ-, and gender-matched typically developing controls (TD). The sample was divided into children (aged 8-14 years) and adolescents/adults (aged 15-47 years) to assess age effects. Results showed no difference in overall performance on the ROCF between HFA and TD children. TD participants displayed improved organizational and planning skills with age and a shift to global processing approaches, but there were no differences in performance between children and adolescents/adults with HFA. There was no evidence of enhanced local processing in either HFA group. These findings suggest that HFA individuals with average IQ scores do not have the clinically demonstrable evidence of the enhanced local processing thought to reflect increased local brain connectivity in more severely autistic individuals. The deficient global processing of the HFA adults reflects dependence of performance on impaired strategic problem-solving abilities, which has been demonstrated to result from under development of neural connectivity between visuo-spatial and frontal brain regions in HFA adults. C1 [Bodner, Kimberly E.; Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Autism Ctr Excellence, Pittsburgh, PA 15213 USA. [Kuschner, Emily S.] Univ Rochester, Dept Clin & Social Sci Psychol, Rochester, NY USA. [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA. [Minshew, Nancy J.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA. RP Minshew, NJ (reprint author), Univ Pittsburgh, Sch Med, Autism Ctr Excellence, 3811 OHara St,Suite 300 Webster Hall, Pittsburgh, PA 15213 USA. EM minshewnj@upmc.edu FU NICHD Collaborative Program of Excellence (CPEA) [HD35469]; NICHD Autism Center of Excellence (ACE) [HD055748] FX Grant sponsor: NICHD Collaborative Program of Excellence (CPEA); Grant number: HD35469; Grant sponsor: NICHD Autism Center of Excellence (ACE); Grant number: HD055748. CR AKSHOOMOFF NA, 1995, NEUROPSYCHOLOGY, V9, P364, DOI 10.1037//0894-4105.9.3.364 AKSHOOMOFF NA, 1995, NEUROPSYCHOLOGY, V9, P378, DOI 10.1037//0894-4105.9.3.378 American Psychiatric Association, 2000, DIAGN STAT MAN MENT Baron-Cohen S, 2006, BRAIN COGNITION, V61, P122, DOI 10.1016/j.bandc.2005.12.011 Baron-Cohen S, 1999, EUR J NEUROSCI, V11, P1891, DOI 10.1046/j.1460-9568.1999.00621.x Behrmann M, 2006, NEUROPSYCHOLOGIA, V44, P110, DOI 10.1016/j.neuropsychologia.2005.04.002 Brian JA, 1996, J CHILD PSYCHOL PSYC, V37, P865, DOI 10.1111/j.1469-7610.1996.tb01482.x Burnette CP, 2005, J AUTISM DEV DISORD, V35, P63, DOI 10.1007/s10803-004-1035-5 Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c de Jonge MV, 2006, J AUTISM DEV DISORD, V36, P677, DOI 10.1007/s10803-006-0113-2 Edgin JO, 2005, J AUTISM DEV DISORD, V35, P729, DOI 10.1007/s10803-005-0020-y Filipek PA, 1999, J AUTISM DEV DISORD, V29, P439, DOI 10.1023/A:1021943802493 Frith U, 1989, EXPLAINING ENIGMA Happe F, 1999, TRENDS COGN SCI, V3, P216, DOI 10.1016/S1364-6613(99)01318-2 Happe FGE, 1996, J CHILD PSYCHOL PSYC, V37, P873, DOI 10.1111/j.1469-7610.1996.tb01483.x Happe FGE, 1997, BRIT J DEV PSYCHOL, V15, P1 Hill EL, 2002, INFANT CHILD DEV, V11, P159, DOI 10.1002/icd.303 Hill EL, 2004, DEV REV, V24, P189, DOI 10.1016/j.dr.2004.01.001 Hollingshead A. B., 1975, 4 FACTOR INDEX SOCIA Howlin P, 2000, J CHILD PSYCHOL PSYC, V41, P561, DOI 10.1017/S0021963099005806 Jolliffe T, 1997, J CHILD PSYCHOL PSYC, V38, P527, DOI 10.1111/j.1469-7610.1997.tb01539.x Just MA, 2007, CEREB CORTEX, V17, P951, DOI 10.1093/cercor/bhl006 Just MA, 2004, BRAIN, V127, P1811, DOI 10.1093/brain/awh199 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004 Kanner L, 1943, NERV CHILD, V2, P217 KANNER L, 1972, J AUTISM CHILD SCHIZ, V2, P9, DOI 10.1007/BF01537624 KANNER L, 1971, J AUTISM CHILD SCHIZ, V1, P119, DOI 10.1007/BF01537953 Koshino H, 2008, CEREB CORTEX, V18, P289, DOI 10.1093/cercor/bhm054 Koshino H, 2005, NEUROIMAGE, V24, P810, DOI 10.1016/j.neuroimage.2004.09.028 LECOUTEUR A, 1989, J AUTISM DEV DISORD, V19, P363 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Luna B, 2001, NEUROIMAGE, V13, P786, DOI 10.1006/nimg.2000.0743 Luna B, 2007, BIOL PSYCHIAT, V61, P474, DOI 10.1016/j.biopsych.2006.02.030 Luna B, 2002, NEUROLOGY, V59, P834 Manjiviona J., 1999, AUTISM, V3, P327, DOI DOI 10.1177/1362361399003004003 Minshew N. J., 1996, PRINCIPLES CHILD NEU, P1713 Minshew N J, 1997, J Int Neuropsychol Soc, V3, P303 Minshew NJ, 1999, NEUROLOGY, V52, P917 Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945 Minshew NJ, 2002, NEUROPSYCHOLOGY, V16, P327, DOI 10.1037//0894-4105.16.3.327 Morgan B, 2003, DEV PSYCHOL, V39, P646, DOI 10.1037/0012-1649.39.4.646 Mottron L, 2003, J CHILD PSYCHOL PSYC, V44, P904, DOI 10.1111/1469-7610.00174 Mottron L, 1999, J CHILD PSYCHOL PSYC, V40, P203, DOI 10.1017/S0021963098003333 NAVON D, 1977, COGNITIVE PSYCHOL, V9, P353, DOI 10.1016/0010-0285(77)90012-3 Osterrieth PA, 1944, ARCH PSYCHOL-GENEVE, V30, P206 OZONOFF S, 1991, J CHILD PSYCHOL PSYC, V32, P1081, DOI 10.1111/j.1469-7610.1991.tb00351.x OZONOFF S, 1994, J CHILD PSYCHOL PSYC, V35, P1015, DOI 10.1111/j.1469-7610.1994.tb01807.x OZONOFF S, 1994, DEV PSYCHOPATHOL, V6, P415, DOI 10.1017/S0954579400006027 Plaisted K, 1999, J CHILD PSYCHOL PSYC, V40, P733, DOI 10.1111/1469-7610.00489 Plaisted KC, 2001, DEVELOPMENT OF AUTISM: PERSPECTIVES FROM THEORY AND RESEARCH, P149 PRIOR M, 1990, J AUTISM DEV DISORD, V20, P581, DOI 10.1007/BF02216063 Rinehart NJ, 2001, AUTISM, V5, P67, DOI 10.1177/1362361301005001007 Rinehart NJ, 2000, J CHILD PSYCHOL PSYC, V41, P769, DOI 10.1017/S002196309900596X Ring HA, 1999, BRAIN, V122, P1305, DOI 10.1093/brain/122.7.1305 Ropar D, 2001, J CHILD PSYCHOL PSYC, V42, P539, DOI 10.1111/1469-7610.00748 RUMSEY JM, 1990, J AUTISM DEV DISORD, V20, P155, DOI 10.1007/BF02284715 Russell J, 2001, J CHILD PSYCHOL PSYC, V42, P317, DOI 10.1017/S0021963001006874 Schlooz WAJM, 2006, J AUTISM DEV DISORD, V36, P1025, DOI 10.1007/s10803-006-0140-z SHAH A, 1983, J CHILD PSYCHOL PSYC, V24, P613, DOI 10.1111/j.1469-7610.1983.tb00137.x SHAH A, 1993, J CHILD PSYCHOL PSYC, V34, P1351, DOI 10.1111/j.1469-7610.1993.tb02095.x Stern R., 1994, BOSTON QUALITATIVE S Sweeney JA, 1996, J NEUROPHYSIOL, V75, P454 Villalobos ME, 2005, NEUROIMAGE, V25, P916, DOI 10.1016/j.neuroimage.2004.12.022 WABER DP, 1986, J CLIN EXP NEUROPSYC, V8, P563, DOI 10.1080/01688638608405176 Wang LX, 2007, COGN NEUROPSYCHOL, V24, P550, DOI 10.1080/13546800701417096 Williams DL, 2006, CHILD NEUROPSYCHOL, V12, P279, DOI 10.1080/09297040600681190 NR 69 TC 10 Z9 10 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2009 VL 2 IS 6 BP 348 EP 358 DI 10.1002/aur.101 PG 11 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 546II UT WOS:000273804100005 PM 19950303 ER PT J AU Babatz, TD Kumar, RA Sudi, J Dobyns, WB Christian, SL AF Babatz, Timothy D. Kumar, Ravinesh A. Sudi, Jyotsna Dobyns, William B. Christian, Susan L. TI Copy Number and Sequence Variants Implicate APBA2 as an Autism Candidate Gene SO AUTISM RESEARCH LA English DT Article ID STRUCTURAL VARIANTS; SPECTRUM DISORDER; SCHIZOPHRENIA; DUPLICATION; MICRODELETION; PROTEINS; MINTS AB We recently reported an autistic proband and affected sibling with maternally inherited microduplications within the 15q13.1 and 15q13.3 regions that contain a total of 4 genes. The amyloid precursor protein-binding protein A2 (APBA2) gene is located within the 15q13.1 duplication and encodes a neuronal adaptor protein essential to synaptic transmission that interacts directly with NRXN1 at the presynaptic membrane. We interpreted this as evidence for a putative role of APBA2 in autism as larger maternal duplications of 15q11-q13 are the most common known cause of autism. We therefore resequenced 512 subjects with autism spectrum disorder (ASD) and 463 controls, and identified 7 novel nonsynonymous coding variants in ASD Subjects compared with 4 in controls. Five of the seven variants in the ASD group were predicted to affect protein function, alter residues conserved across 18 species, or both. All of the variants for which parental DNA was available were inherited. We also found two different nonsynonymous variants in two siblings with autism: (1) a paternally inherited heterozygous 6 bp deletion and (2) a maternally inherited heterozygous missense Mutation, the latter also found in a single control. These results indicate compound heterozygous mutations of APBA2 in this autism sibship. The co-occurrence of two nonsynonymous mutations in both affected siblings in a single family, each transmitted from a different unaffected parent, Suggest a role for APBA2 mutations in rare individuals with ASD. C1 [Babatz, Timothy D.; Kumar, Ravinesh A.; Sudi, Jyotsna; Dobyns, William B.; Christian, Susan L.] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA. [Dobyns, William B.] Univ Chicago, Dept Neurol, Chicago, IL 60637 USA. [Dobyns, William B.] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA. RP Christian, SL (reprint author), Univ Chicago, Dept Human Genet, CLSC319,MC0077,920 E 58th St, Chicago, IL 60637 USA. EM schrist@bsd.uchicago.edu FU NIH NINDS [R01 NS051812] FX Grant sponsor: NIH NINDS; Grant number: R01 NS051812. CR Biederer T, 2000, J BIOL CHEM, V275, P39803, DOI 10.1074/jbc.C000656200 Christian SL, 2008, BIOL PSYCHIAT, V63, P1111, DOI 10.1016/j.biopsych.2008.01.009 Cook EH, 1997, AM J HUM GENET, V60, P928 de Stahl TD, 2008, HUM MUTAT, V29, P398, DOI 10.1002/humu.20659 Feng JN, 2006, NEUROSCI LETT, V409, P10, DOI 10.1016/j.neulet.2006.08.017 Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559 Ho A, 2006, J NEUROSCI, V26, P13089, DOI 10.1523/JNEUROSCI.2855-06.2006 Kim HG, 2008, AM J HUM GENET, V82, P199, DOI 10.1016/j.ajhg.2007.09.011 Kirov G, 2008, HUM MOL GENET, V17, P458, DOI 10.1093/hmg/ddm323 Kumar RA, 2009, CURR NEUROL NEUROSCI, V9, P188, DOI 10.1007/s11910-009-0029-2 Kumar RA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004582 Okamoto M, 1997, J BIOL CHEM, V272, P31459, DOI 10.1074/jbc.272.50.31459 O'Roak BJ, 2008, AUTISM RES, V1, P4, DOI 10.1002/aur.3 Rujescu D, 2009, EPIDEMIOL PSICHIAT S, V18, P91 Sano Y, 2009, J NEUROSCI, V29, P5884, DOI 10.1523/JNEUROSCI.5756-08.2009 SHAIKH TH, 2009, GENOME RES, V10, P1682 Sharp AJ, 2008, NAT GENET, V40, P322, DOI 10.1038/ng.93 Sutcliffe JS, 2003, BMC GENOMICS, V4, DOI 10.1186/1471-2164-4-15 Szatmari P, 2007, NAT GENET, V39, P319, DOI 10.1038/ng1985 van Bon BWM, 2009, J MED GENET, V46, P511, DOI 10.1136/jmg.2008.063412 Walsh T, 2008, SCIENCE, V320, P539, DOI 10.1126/science.1155174 NR 21 TC 12 Z9 12 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2009 VL 2 IS 6 BP 359 EP 364 DI 10.1002/aur.107 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 546II UT WOS:000273804100006 PM 20029827 ER PT J AU Cook, EH AF Cook, Edwin H., Jr. TI Literature Review: Similar Prevalence of ASD across the Life Span; Amygdala Enlargement in Young Children SO AUTISM RESEARCH LA English DT Review ID AUTISM C1 Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA. RP Cook, EH (reprint author), Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA. EM ecook@psych.uic.edu CR Baron-Cohen S, 2001, J AUTISM DEV DISORD, V31, P5, DOI 10.1023/A:1005653411471 Brugha T., 2009, AUTISM SPECTRUM DISO Kogan M. D., 2009, PEDIATRICS Schumann CM, 2009, BIOL PSYCHIAT, V66, P942, DOI 10.1016/j.biopsych.2009.07.007 NR 4 TC 0 Z9 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD DEC PY 2009 VL 2 IS 6 BP 365 EP 366 DI 10.1002/aur.112 PG 2 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 546II UT WOS:000273804100007 ER PT J AU Bailey, AJ AF Bailey, Anthony J. TI Where are the Autism Economists? SO AUTISM RESEARCH LA English DT Editorial Material RI Bailey, Anthony/J-2860-2014 OI Bailey, Anthony/0000-0003-4257-972X NR 0 TC 2 Z9 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2009 VL 2 IS 5 BP 245 EP 245 DI 10.1002/aur.99 PG 1 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 525FW UT WOS:000272200900001 PM 19844947 ER PT J AU Scott, JA Schumann, CM Goodlin-Jones, BL Amaral, DG AF Scott, Julia A. Schumann, Cynthia Mills Goodlin-Jones, Beth L. Amaral, David G. TI A Comprehensive Volumetric Analysis of the Cerebellum in Children and Adolescents with Autism Spectrum Disorder SO AUTISM RESEARCH LA English DT Article DE Asperger; MRI; developmental delays; vermis; neurodevelopmental disorder ID DIAGNOSTIC OBSERVATION SCHEDULE; POSTERIOR-FOSSA STRUCTURES; MAGNETIC-RESONANCE; INFANTILE-AUTISM; DEVELOPMENTAL DISORDERS; BRAIN; MRI; HYPOPLASIA; INDIVIDUALS; IMITATION AB Magnetic resonance imaging (MRI) and Postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to "plane of section artifacts" may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 1.8.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders. C1 [Scott, Julia A.; Schumann, Cynthia Mills; Goodlin-Jones, Beth L.; Amaral, David G.] Univ Calif Davis, MIND Inst, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA. RP Amaral, DG (reprint author), Univ Calif Davis, MIND Inst, Dept Psychiat & Behav Sci, 2825 50th St, Sacramento, CA 95817 USA. EM dgamaral@ucdavis.edu FU NIH [MH41479, MH01832, MH01142, MH50047, NS16980, HD31715]; UC Davis M.I.N.D. Institute FX Grant sponsor: NIH; Grant numbers: MH41479; MH01832; MH01142; MH50047; NS16980; HD31715; Grant sponsor: UC Davis M.I.N.D. Institute. CR Aldinger KA, 2009, NAT GENET, V41, P1037, DOI 10.1038/ng.422 Angevine JB, 1961, HUMAN CEREBELLUM ATL Astley SJ, 2009, ALCOHOL CLIN EXP RES, V33, P1671, DOI 10.1111/j.1530-0277.2009.01004.x Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Bish JP, 2006, NEUROSCI LETT, V399, P245, DOI 10.1016/j.neulet.2006.02.001 Ciesielski KT, 1997, NEUROPSYCHOLOGIA, V35, P643, DOI 10.1016/S0028-3932(96)00119-4 COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102 Courchesne E, 2001, NEUROLOGY, V57, P245 COURCHESNE E, 1994, NEUROLOGY, V44, P214 Crooks R, 2000, EPILEPSY RES, V41, P63, DOI 10.1016/S0920-1211(00)00133-9 Curatolo P, 2009, EUR J PAEDIATR NEURO, V13, P299, DOI 10.1016/j.ejpn.2008.06.003 DILAVORE PC, 1995, J AUTISM DEV DISORD, V25, P355, DOI 10.1007/BF02179373 GAFFNEY GR, 1987, AM J DIS CHILD, V141, P1330 Hallahan B, 2009, PSYCHOL MED, V39, P337, DOI 10.1017/S0033291708003383 Hardan AY, 2001, J AM ACAD CHILD PSY, V40, P666, DOI 10.1097/00004583-200106000-00011 HASHIMOTO T, 1995, J AUTISM DEV DISORD, V25, P1, DOI 10.1007/BF02178163 Hazlett HC, 2005, ARCH GEN PSYCHIAT, V62, P1366, DOI 10.1001/archpsyc.62.12.1366 Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110 HOLTTUM JR, 1992, BIOL PSYCHIAT, V32, P1091, DOI 10.1016/0006-3223(92)90189-7 Kaufmann WE, 2003, J CHILD NEUROL, V18, P463, DOI 10.1177/08830738030180070501 Kemper TL, 2002, MOL PSYCHIATR, V7, pS12, DOI 10.1038/sj.mp.4001165 KLEIMAN MD, 1992, NEUROLOGY, V42, P753 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lotspeich L, 2004, ARCH GEN PSYCHIAT, V61, P291, DOI 10.1001/archpsyc.61.3.291 Manes F, 1999, J NEUROPSYCH CLIN N, V11, P470 McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332 Palmen SJMC, 2005, PSYCHOL MED, V35, P561, DOI 10.1017/S0033291704003496 PIVEN J, 1992, BIOL PSYCHIAT, V31, P491, DOI 10.1016/0006-3223(92)90260-7 ROBB RA, 1989, COMPUT MED IMAG GRAP, V13, P433, DOI 10.1016/0895-6111(89)90285-1 Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162 Roid G., 1997, LEITER INT PERFORMAN Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56 Schaefer GB, 1996, ANN NEUROL, V39, P382, DOI 10.1002/ana.410390316 Schmahmann J. D., 2000, MRI ATLAS HUMAN CERE Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004 Soto-Ares G, 2003, PEDIATR RADIOL, V33, P334, DOI 10.1007/s00247-003-0891-z Stanfield AC, 2008, EUR PSYCHIAT, V23, P289, DOI 10.1016/j.eurpsy.2007.05.006 Webb SJ, 2009, PSYCHIAT RES-NEUROIM, V172, P61, DOI 10.1016/j.pscychresns.2008.06.001 Wechsler D, 1999, WECHSLER ABBREVIATED Whitney ER, 2008, CEREBELLUM, V7, P406, DOI 10.1007/s12311-008-0043-y Williams JHG, 2001, NEUROSCI BIOBEHAV R, V25, P287, DOI 10.1016/S0149-7634(01)00014-8 NR 42 TC 37 Z9 38 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2009 VL 2 IS 5 BP 246 EP 257 DI 10.1002/aur.97 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 525FW UT WOS:000272200900002 PM 19885834 ER PT J AU Cukier, HN Skaar, DA Rayner-Evans, MY Konidari, I Whitehead, PL Jaworski, JM Cuccaro, ML Pericak-Vance, MA Gilbert, JR AF Cukier, Holly N. Skaar, David A. Rayner-Evans, Melissa Y. Konidari, Ioanna Whitehead, Patrice L. Jaworski, James M. Cuccaro, Michael L. Pericak-Vance, Margaret A. Gilbert, John R. TI Identification of Chromosome 7 Inversion Breakpoints in an Autistic Family Narrows Candidate Region for Autism Susceptibility SO AUTISM RESEARCH LA English DT Article DE molecular genetics; paracentric inversion; fluorescent in situ hybridization (FISH); genome-wide association study (GWAS) ID COPY-NUMBER VARIATION; HUMAN GENOME; LANGUAGE IMPAIRMENT; TRANSLOCATION BREAKPOINT; STRUCTURAL VARIATION; MENTAL-RETARDATION; GENERAL PEDIGREES; TOURETTE-SYNDROME; FINE-SCALE; ARRAY-CGH AB Chromosomal breaks and rearrangements have been observed in conjunction with autism and autistic spectrum disorders. A chromosomal inversion has been previously reported in autistic siblings, spanning the region from approximately 7q22.1 to 7q31. This family is distinguished by having multiple individuals with autism and associated disabilities. The region containing the inversion has been strongly implicated in autism by multiple linkage studies, and has been particularly associated with language defects in autism as well as in other disorders with language components. Mapping of the inversion breakpoints by FISH has localized the inversion to the region spanning approximately 99-108.75 Mb of chromosome 7. The proximal breakpoint has the potential to disrupt either the coding sequence or regulatory regions of a number of cytochrome P450 genes while the distal region falls in a relative gene desert. Copy number variant analysis of the breakpoint regions detected no duplication or deletion that could clearly be associated with disease status. Association analysis in our autism data set using single nucleotide polymorphisms located near the breakpoints showed no significant association with proximal breakpoint markers, but has identified markers near the distal breakpoint (similar to 108-110 Mb) with significant associations to autism. The chromosomal abnormality in this family strengthens the case for an autism susceptibility gene in the chromosome 7q22-31 region and targets a candidate region for further investigation. C1 [Cukier, Holly N.; Rayner-Evans, Melissa Y.; Konidari, Ioanna; Whitehead, Patrice L.; Jaworski, James M.; Cuccaro, Michael L.; Pericak-Vance, Margaret A.; Gilbert, John R.] Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA. [Skaar, David A.] Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC USA. RP Gilbert, JR (reprint author), 1501 NW 10th Ave, Miami, FL 33136 USA. EM jgilbert@med.miami.edu FU The National Institute of Neurological Disorders and Stroke [7P01 NS 26630-19] FX Grant sponsor: The National Institute of Neurological Disorders and Stroke; Grant number: 7P01 NS 26630-19. CR Ashley-Koch A, 1999, GENOMICS, V61, P227, DOI 10.1006/geno.1999.5968 Baron-Cohen S, 1999, J CHILD PSYCHOL PSYC, V40, P213 Barrett S, 1999, AM J MED GENET, V88, P609 Bayou N, 2008, J BIOMED BIOTECHNOL, DOI 10.1155/2008/231904 BoghosianSell L, 1996, AM J HUM GENET, V59, P999 Bonora E, 2005, EUR J HUM GENET, V13, P198, DOI 10.1038/sj.ejhg.5201315 Conrad DF, 2006, NAT GENET, V38, P75, DOI 10.1038/ng1697 Cuccaro ML, 2003, J AUTISM DEV DISORD, V33, P87, DOI 10.1023/A:1022286622534 de Smith AJ, 2007, HUM MOL GENET, V16, P2783, DOI 10.1093/hmg/ddm208 Dykens EM, 2004, MENT RETARD DEV D R, V10, P284, DOI 10.1002/mrdd.20042 Folstein SE, 2000, AM J HUM GENET, V67, P278, DOI 10.1086/303034 Hamilton SP, 2005, BMC GENET, V6, DOI 10.1186/1471-2156-6-52 Hutcheson Holli B, 2004, BMC Med Genet, V5, P12, DOI 10.1186/1471-2350-5-12 Hutcheson HB, 2003, AM J MED GENET B, V117B, P90, DOI 10.1002/ajmg.b.10033 Bailey A, 1998, HUM MOL GENET, V7, P571 Kidd JM, 2008, NATURE, V453, P56, DOI 10.1038/nature06862 Korbel JO, 2007, P NATL ACAD SCI USA, V104, P10110, DOI 10.1073/pnas.0703834104 Lennon PA, 2007, AM J MED GENET A, V143A, P791, DOI 10.1002/ajmg.a.31632 LIVAK KJ, 1995, NAT GENET, V9, P341, DOI 10.1038/ng0495-341 LORD C, 1989, J AUTISM DEV DISORD, V19, P185, DOI 10.1007/BF02211841 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Ma DQ, 2009, ANN HUM GENET, V73, P263, DOI 10.1111/j.1469-1809.2009.00523.x Maestrini E, 2009, MOL PSYCHIAT Martin ER, 2000, AM J HUM GENET, V67, P146, DOI 10.1086/302957 Martin ER, 2003, GENET EPIDEMIOL, V25, P203, DOI 10.1002/gepi.10258 McCarroll SA, 2006, NAT GENET, V38, P86, DOI 10.1038/ng1696 NAWA H, 1984, NATURE, V312, P729, DOI 10.1038/312729a0 NEITZEL H, 1986, HUM GENET, V73, P320, DOI 10.1007/BF00279094 O'Brien EK, 2003, AM J HUM GENET, V72, P1536, DOI 10.1086/375403 Perry GH, 2008, AM J HUM GENET, V82, P685, DOI 10.1016/j.ajhg.2007.12.010 Persico AM, 2001, MOL PSYCHIATR, V6, P150, DOI 10.1038/sj.mp.4000850 Petek E, 2001, AM J HUM GENET, V68, P848, DOI 10.1086/319523 PINKEL D, 1986, P NATL ACAD SCI USA, V83, P2934, DOI 10.1073/pnas.83.9.2934 PURCELL S, 2008, GENETIC POWER CALCUL Redon R, 2006, NATURE, V444, P444, DOI 10.1038/nature05329 Sebat J, 2007, SCIENCE, V316, P445, DOI 10.1126/science.1138659 Shao YJ, 2002, AM J MED GENET, V114, P99, DOI 10.1002/ajmg.10153 Skaar DA, 2005, MOL PSYCHIATR, V10, P563, DOI 10.1038/sj.mp.4001614 Tentler D, 2001, AM J MED GENET, V105, P729, DOI 10.1002/ajmg.1607 Tuzun E, 2005, NAT GENET, V37, P727, DOI 10.1038/ng1562 Tyson C, 2004, AM J MED GENET A, V129A, P254, DOI 10.1002/ajmg.a.30245 Vincent JB, 2008, PSYCHIAT GENET, V18, P101, DOI 10.1097/YPG.0b013e3282f97df7 Vincent JB, 2000, AM J HUM GENET, V67, P510, DOI 10.1086/303005 Wang K, 2009, NATURE, V459, P528, DOI 10.1038/nature07999 Warburton P, 2000, AM J MED GENET, V96, P228, DOI 10.1002/(SICI)1096-8628(20000403)96:2<228::AID-AJMG20>3.0.CO;2-G Xu Jie, 2004, Current Genomics, V5, P347, DOI 10.2174/1389202043349246 Zeesman S, 2006, AM J MED GENET A, V140A, P509, DOI 10.1002/ajmg.a.31110 NR 47 TC 7 Z9 9 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2009 VL 2 IS 5 BP 258 EP 266 DI 10.1002/aur.96 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 525FW UT WOS:000272200900003 PM 19877165 ER PT J AU Kates, WR Ikuta, I Burnette, CP AF Kates, Wendy R. Ikuta, Ichiro Burnette, Courtney P. TI Gyrification Patterns in Monozygotic Twin Pairs Varying in Discordance for Autism SO AUTISM RESEARCH LA English DT Article DE Autism; twins; cortical gyrification; MRI; brain ID MIRROR NEURON SYSTEM; HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDERS; CEREBRAL-CORTEX; BRAIN SIZE; COMMUNICATION DEFICITS; CORTICAL DEVELOPMENT; INFANTILE-AUTISM; CHILDREN; MRI AB In order to disentangle genetic and environmental contributions to cortical anomalies in children with autism, we investigated cortical folding patterns in a cohort of 14 monozygotic (MZ) twin pairs who displayed a range of phenotypic discordance for autism, and 14 typically developing community controls. Cortical folding was assessed with the gyrification index, which was calculated on high resolution anatomic MR images. We found that the cortical folding patterns across most lobar regions of the cerebral cortex was highly discordant within MZ twin pairs. In addition, children with autism and their co-twins exhibited increased cortical folding in the right parietal lobe, relative to age- and gender-matched typical developing children. Increased folding in the right parietal lobe was associated with more symptoms of autism for co-twins. Finally, the robust association between cortical folding and IQ observed in typical children was not observed in either children with autism or their co-twins. These findings, which contribute to our understanding of the limits of genetic liability in autism, Suggest that anomalies in the structural integrity of the cortex in this PDD may disrupt the association between cortical folding and intelligence that has been reported in typical individuals, and may account, in part, for the deficits in visual spatial attention and in social cognition that have been reported in children with autism. C1 [Kates, Wendy R.; Ikuta, Ichiro] SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY 13210 USA. [Kates, Wendy R.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA. [Burnette, Courtney P.] Vanderbilt Univ, Kennedy Ctr, Nashville, TN USA. RP Kates, WR (reprint author), SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, 750 E Adams St, Syracuse, NY 13210 USA. EM katesw@upstate.edu FU National Alliance for Autism Research (NAAR); Autism Society of America; The Research Foundation of SUNY FX Grant sponsors: National Alliance for Autism Research (NAAR); Autism Society of America; The Research Foundation of SUNY. CR ANDREASEN NC, 1993, AM J PSYCHIAT, V150, P130 Bartley AJ, 1997, BRAIN, V120, P257, DOI 10.1093/brain/120.2.257 Belmonte MK, 2003, COGNITIVE BRAIN RES, V17, P651, DOI 10.1016/S0926-6410(03)00189-7 Berthier M L, 1990, J Neuropsychiatry Clin Neurosci, V2, P197 Biondi A, 1998, AM J NEURORADIOL, V19, P1361 Blanton RE, 2001, PSYCHIAT RES-NEUROIM, V107, P29, DOI 10.1016/S0925-4927(01)00091-9 Bloss CS, 2007, J AM ACAD CHILD PSY, V46, P515, DOI 10.1097/chi.0b013e318030e28b Brambilla P, 2003, BRAIN RES BULL, V61, P557, DOI 10.1016/j.brainresbull.2003.06.001 Brieber S, 2007, J CHILD PSYCHOL PSYC, V48, P1251, DOI 10.1111/j.1469-7610.2007.01799.x Buccino G, 2008, CURR OPIN PSYCHIATR, V21, P281, DOI 10.1097/YCO.0b013e3282fbcd32 Carper RA, 2005, BIOL PSYCHIAT, V57, P126, DOI 10.1016/j.biopsych.2004.11.005 Carper RA, 2002, NEUROIMAGE, V16, P1038, DOI 10.1006/nimg.2002.1099 Cherkassky VL, 2006, NEUROREPORT, V17, P1687, DOI 10.1097/01.wnr.0000239956.45448.4c COURCHESNE E, 1988, NEW ENGL J MED, V318, P1349, DOI 10.1056/NEJM198805263182102 Courchesne E, 2001, NEUROLOGY, V57, P245 COURCHESNE E, 1993, AM J ROENTGENOL, V160, P387 Courchesne E, 2003, JAMA-J AM MED ASSOC, V290, P337, DOI 10.1001/jama.290.3.337 Dapretto M, 2006, NAT NEUROSCI, V9, P28, DOI 10.1038/nn1611 FOLSTEIN S, 1977, J CHILD PSYCHOL PSYC, V18, P297, DOI 10.1111/j.1469-7610.1977.tb00443.x Hadjikhani N, 2006, CEREB CORTEX, V16, P1276, DOI 10.1093/cercor/bh069 Haier RJ, 2004, NEUROIMAGE, V23, P425, DOI 10.1016/j.neuroimage.2004.04.025 Haist F, 2005, DEV NEUROPSYCHOL, V27, P425, DOI 10.1207/s15326942dn2703_7 Hardan AY, 2006, AM J PSYCHIAT, V163, P1290, DOI 10.1176/appi.ajp.163.7.1290 Hardan AY, 2004, PSYCHIAT RES-NEUROIM, V131, P263, DOI 10.1016/j.pscychresns.2004.06.001 Harris JM, 2004, BIOL PSYCHIAT, V56, P182, DOI 10.1016/j.biopsych.2004.04.007 Hazlett HC, 2006, BIOL PSYCHIAT, V59, P1, DOI 10.1016/j.biopsych.2005.06.015 Herbert MR, 2003, BRAIN, V126, P1182, DOI 10.1093/brain/awg110 Hilgetag CC, 2006, PLOS COMPUT BIOL, V2, P146, DOI 10.1371/journal.pcbi.0020022 Iacoboni M, 2006, NAT REV NEUROSCI, V7, P942, DOI 10.1038/nrn2024 Iacoboni M, 2007, ANN NEUROL, V62, P213, DOI 10.1002/ana.21198 Im K, 2008, CEREB CORTEX, V18, P2181, DOI 10.1093/cercor/bhm244 Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004 Kaplan DM, 1997, PSYCHIAT RES-NEUROIM, V76, P15, DOI 10.1016/S0925-4927(97)00055-3 Kates WR, 1999, PSYCHIAT RES-NEUROIM, V91, P11, DOI 10.1016/S0925-4927(99)00011-6 Kates WR, 2004, AM J PSYCHIAT, V161, P539, DOI 10.1176/appi.ajp.161.3.539 Kates WR, 1998, ANN NEUROL, V43, P782, DOI 10.1002/ana.410430613 Ke XY, 2008, NEUROREPORT, V19, P921, DOI 10.1097/WNR.0b013e328300edf3 Kesler SR, 2006, NEUROPSYCHOLOGIA, V44, P445, DOI 10.1016/j.neuropsychologia.2005.05.015 Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334 Klintsova AY, 1999, CURR OPIN NEUROBIOL, V9, P203, DOI 10.1016/S0959-4388(99)80028-2 LeCouteur A, 1996, J CHILD PSYCHOL PSYC, V37, P785 Levitt JG, 2003, CEREB CORTEX, V13, P728, DOI 10.1093/cercor/13.7.728 Lohmann G, 1999, CEREB CORTEX, V9, P754, DOI 10.1093/cercor/9.7.754 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, J AUTISM DEV DISORD, V30, P205, DOI 10.1023/A:1005592401947 Lord C, 2001, AM J MED GENET, V105, P36, DOI 10.1002/1096-8628(20010108)105:1<36::AID-AJMG1053>3.0.CO;2-4 Luders E, 2008, CEREB CORTEX, V18, P2019, DOI 10.1093/cercor/bhm227 Markham JA, 2004, NEURON GLIA BIOL, V1, P351, DOI 10.1017/S1740925X05000219 Mazefsky CA, 2008, RES AUTISM SPECT DIS, V2, P320, DOI 10.1016/j.rasd.2007.08.002 McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332 Minshew NJ, 2007, ARCH NEUROL-CHICAGO, V64, P945, DOI 10.1001/archneur.64.7.945 Mitchell SR, 2009, AM J PSYCHIAT, V166, P917, DOI 10.1176/appi.ajp.2009.08101538 Monk CS, 2009, NEUROIMAGE, V47, P764, DOI 10.1016/j.neuroimage.2009.04.069 Muller RA, 2003, AM J PSYCHIAT, V160, P1847, DOI 10.1176/appi.ajp.160.10.1847 Narr KL, 2007, CEREB CORTEX, V17, P2163, DOI 10.1093/cercor/bhl125 Nordahl CW, 2007, J NEUROSCI, V27, P11725, DOI 10.1523/JNEUROSCI.0777-07.2007 Oberman LM, 2007, PSYCHOL BULL, V133, P310, DOI 10.1037/0033-2909.133.2.310 PIVEN J, 1990, AM J PSYCHIAT, V147, P734 Piven J, 1996, J AM ACAD CHILD PSY, V35, P530, DOI 10.1097/00004583-199604000-00020 PIVEN J, 1995, AM J PSYCHIAT, V152, P1145 REISS AL, 2002, BRAINIMAGE Reiss AL, 1996, BRAIN, V119, P1763, DOI 10.1093/brain/119.5.1763 Rojas DC, 2006, BMC PSYCHIATRY, V6, DOI 10.1186/1471-244X-6-56 Rutter M, 1997, HDB AUTISM PERVASIVE, P370 Schmitt JE, 2002, DEV MED CHILD NEUROL, V44, P292 Schumann CM, 2004, J NEUROSCI, V24, P6392, DOI 10.1523/JNEUROSCI.1297-04.2004 Shaw P, 2006, NATURE, V440, P676, DOI 10.1038/nature04513 Solomon M, 2009, NEUROPSYCHOLOGIA, V47, P2515, DOI 10.1016/j.neuropsychologia.2009.04.019 Sowell ER, 2002, CEREB CORTEX, V12, P17, DOI 10.1093/cercor/12.1.17 Sparks BF, 2002, NEUROLOGY, V59, P184 STEFFENBURG S, 1989, J CHILD PSYCHOL PSYC, V30, P405, DOI 10.1111/j.1469-7610.1989.tb00254.x Thorndike R. L., 1986, GUIDE ADM SCORING 4 Toro R, 2008, CEREB CORTEX, V18, P2352, DOI 10.1093/cercor/bhm261 Toro R, 2005, CEREB CORTEX, V15, P1900, DOI 10.1093/cercor/bhi068 Tsuang Ming T, 2004, World Psychiatry, V3, P73 VanEssen DC, 1997, NATURE, V385, P313 Villarrea M, 2008, NEUROPSYCHOLOGIA, V46, P2371, DOI 10.1016/j.neuropsychologia.2008.03.004 Wechsler D., 1991, MANUAL WECHSLER INTE White T, 2002, CEREB CORTEX, V12, P486, DOI 10.1093/cercor/12.5.486 Williams JHG, 2006, NEUROPSYCHOLOGIA, V44, P610, DOI 10.1016/j.neuropsychologia.2005.06.010 ZILLES K, 1988, ANAT EMBRYOL, V179, P173, DOI 10.1007/BF00304699 NR 81 TC 20 Z9 20 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2009 VL 2 IS 5 BP 267 EP 278 DI 10.1002/aur.98 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 525FW UT WOS:000272200900004 PM 19890876 ER PT J AU Gastgeb, HZ Rump, KM Best, CA Minshew, NJ Strauss, MS AF Gastgeb, Holly Zajac Rump, Keiran M. Best, Catherine A. Minshew, Nancy J. Strauss, Mark S. TI Prototype Formation in Autism: Can Individuals with Autism Abstract Facial Prototypes? SO AUTISM RESEARCH LA English DT Article DE prototype; autism; categorization; face perception ID CATEGORIZATION; RECOGNITION; INFORMATION; KNOWLEDGE; CHILDREN; INTACT; MEMORY AB Prototype formation is a critical skill for category learning. Research Suggests that individuals with autism may have a deficit in prototype formation of some objects; however, results are mixed. This Study used a natural category, faces, to further examine prototype formation in high-functioning individuals with autism. High-functioning children (age 8-13 years) and adults with autism (age 17-53 years) and matched controls were tested in a facial prototype formation task that has been used to test prototype formation abilities in typically developing infants and adults [Strauss, 1979]. Participants were familiarized to a series of faces depicting subtle variations in the spatial distance of facial features, and were then given a forced choice familiarity test between the mean prototype and the mode prototype. Overall, individuals in the autism group were significantly less likely to select the mean prototype face. Even though the children With autism showed this difference in prototype formation, this pattern was driven primarily by the adults, because the adults with autism were approximately four times less likely to select the mean prototype than were the control adults. These results provide further evidence that individuals with autism have difficulty abstracting subtle spatial information that is necessary not only for the formation of a mean prototype, but also for categorizing faces and objects. C1 [Gastgeb, Holly Zajac; Rump, Keiran M.; Best, Catherine A.; Strauss, Mark S.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA. [Minshew, Nancy J.] Univ Pittsburgh, Dept Psychiat & Neurol, Sch Med, Pittsburgh, PA 15260 USA. RP Strauss, MS (reprint author), Univ Pittsburgh, Dept Psychol, 210 S Bouquet St, Pittsburgh, PA 15260 USA. EM strauss@pitt.edu FU NICHD Collaborative Program of Excellence in Autism (CPEA) [P01-HD35469] FX Grant sponsor: NICHD Collaborative Program of Excellence in Autism (CPEA); Grant number: P01-HD35469. CR Gastgeb HZ, 2006, CHILD DEV, V77, P1717, DOI 10.1111/j.1467-8624.2006.00969.x Hayes BK, 2000, J INTELLECT DEV DIS, V25, P217, DOI 10.1080/13668250020006312 HAYES BK, 1993, AM J MENT RETARD, V98, P293 HOMA D, 1993, MEM COGNITION, V21, P529, DOI 10.3758/BF03197184 Keri S, 2001, SCHIZOPHR RES, V52, P261, DOI 10.1016/S0920-9964(00)00092-X Klinger L., 2006, NEW DEV AUTISM FUTUR, P75 Klinger LG, 2001, DEV PSYCHOPATHOL, V13, P111, DOI 10.1017/S0954579401001080 Lord C, 2003, AUTISM DIAGNOSTIC OB Molesworth CJ, 2008, J AUTISM DEV DISORD, V38, P1721, DOI 10.1007/s10803-008-0557-7 Molesworth CJ, 2005, J CHILD PSYCHOL PSYC, V46, P661, DOI 10.1111/j.1469-7610.2004.00383.x Plaisted KC, 2000, UNDERSTANDING OTHER, P222 POSNER MI, 1968, J EXP PSYCHOL, V77, P353, DOI 10.1037/h0025953 REED SK, 1972, COGNITIVE PSYCHOL, V3, P382, DOI 10.1016/0010-0285(72)90014-X Rubenstein AJ, 1999, DEV PSYCHOL, V35, P848, DOI 10.1037//0012-1649.35.3.848 RUTTER M, 2003, AUTISM DIAGNOSTIC IN Sasson NJ, 2006, J AUTISM DEV DISORD, V36, P381, DOI 10.1007/s10803-006-0076-3 STRAUSS MS, 1979, J EXP PSYCHOL-HUM L, V5, P618, DOI 10.1037//0278-7393.5.6.618 Wechsler D, 1999, WECHSLER ABBREVIATED YOUNGER B, 1988, DEV PSYCHOL, V24, P611, DOI 10.1037/0012-1649.24.5.611 YOUNGER B, 1990, J EXP CHILD PSYCHOL, V50, P131, DOI 10.1016/0022-0965(90)90036-8 NR 20 TC 18 Z9 18 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2009 VL 2 IS 5 BP 279 EP 284 DI 10.1002/aur.93 PG 6 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 525FW UT WOS:000272200900005 PM 19877157 ER PT J AU Cook, EH AF Cook, Edwin H., Jr. TI Literature Review: Gastrointestinal Symptoms in ASD, Brain Structure of Identical Twins with ASD SO AUTISM RESEARCH LA English DT Review ID AUTISM; DISCORDANT C1 Univ Illinois, Inst Juvenile Res, Dept Psychiat, Chicago, IL 60608 USA. RP Cook, EH (reprint author), Univ Illinois, Inst Juvenile Res, Dept Psychiat, Chicago, IL 60608 USA. EM ecook@psych.uic.edu CR Ibrahim SH, 2009, PEDIATRICS, V124, P680, DOI 10.1542/peds.2008-2933 Kates WR, 2004, AM J PSYCHIAT, V161, P539, DOI 10.1176/appi.ajp.161.3.539 Mitchell SR, 2009, AM J PSYCHIAT, V166, P917, DOI 10.1176/appi.ajp.2009.08101538 NR 3 TC 0 Z9 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD OCT PY 2009 VL 2 IS 5 BP 285 EP 286 DI 10.1002/aur.95 PG 2 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 525FW UT WOS:000272200900006 PM 19839058 ER PT J AU Windham, GC Fessel, K Grether, JK AF Windham, Gayle C. Fessel, Karen Grether, Judith K. TI Autism Spectrum Disorders in Relation to Parental Occupation in Technical Fields SO AUTISM RESEARCH LA English DT Article DE autism; parental occupation; broader autism phenotype; risk factors ID MULTIPLE-INCIDENCE; PHENOTYPE; POPULATION; QUOTIENT; FAMILIES AB A previous study reported that fathers of children with autism spectrum disorders (ASD) were more likely to work as engineers, requiring "systemizing skills," and Suggesting a distinct phenotype, but alternatively this may have been related to selection biases. We conducted a population-based Study to explore whether fathers, or mothers, of children with ASD are over-represented in fields requiring highly technical skills. Subjects included 284 children with ASD and 659 gender-matched controls, born in 1994 in the San Francisco Bay Area. Parental occupation and industry were abstracted verbatim from birth certificates. Engineering, computer programming, and science were examined as highly technical occupations. To limit bias by parental socio-economic status, we selected a referent group of occupations that seemed professionally similar but of a less technical nature. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for parental age, education, and child race. Mothers of cases were somewhat more likely to work in hi-tech Occupations (6.7%) than mothers of controls (4.0%, P = 0.07), but little difference was observed among fathers, nor for engineering separately. Compared to parents in other "white collar" occupations, the adjusted OR for highly technical occupations among mothers was 2.5 (95% CI: 1.2-5.3) and among fathers was 1.3 (95% CI: 0.79-2.1.), with no evidence of a joint effect observed. Our results regarding maternal occupation in technical fields being associated with ASD in offspring suggest further study to distinguish parental occupation as a phenotypic marker of genetic loading vs. other social or exposure factors. C1 [Windham, Gayle C.; Grether, Judith K.] Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, Richmond, CA 94804 USA. [Fessel, Karen] Impact Assessment Inc, La Jolla, CA USA. RP Windham, GC (reprint author), Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, 850 Marina Bay Pkwy,Bldg P, Richmond, CA 94804 USA. EM gayle.windham@cdph.ca.gov CR Austin EJ, 2005, PERS INDIV DIFFER, V38, P451, DOI 10.1016/j.paid.2004.04.022 Baron-Cohen S, 2006, ARCH DIS CHILD, V91, P2 Baron-Cohen S., 1998, AUTISM, V2, P296, DOI 10.1177/1362361398023008 Baron-Cohen Simon, 1997, AUTISM, V1, P101, DOI 10.1177/1362361397011010 Bishop DVM, 2004, J CHILD PSYCHOL PSYC, V45, P1431, DOI 10.1111/j.1469-7610.2004.00325.x *BLS, STAND OCC CLASS SOC Constantino JN, 2005, BIOL PSYCHIAT, V57, P655, DOI 10.1016/j.biopsych.2004.12.014 Croen LA, 2002, J AUTISM DEV DISORD, V32, P217, DOI 10.1023/A:1015405914950 Hertz-Picciotto I, 2006, ENVIRON HEALTH PERSP, V114, P1119, DOI 10.1289/ehp.8483 Jarrold C., 1998, AUTISM, V2, P281, DOI 10.1177/1362361398023006 KRIEGER N, 1992, AM J PUBLIC HEALTH, V82, P703, DOI 10.2105/AJPH.82.5.703 Losh M, 2008, AM J MED GENET B, V147B, P424, DOI 10.1002/ajmg.b.30612 Newschaffer CJ, 2007, ANNU REV PUBL HEALTH, V28, P235, DOI 10.1146/annurev.publhealth.28.021406.144007 Piven J, 1997, AM J PSYCHIAT, V154, P185 ROSS PE, 2006, IEEE SPECTRUM DEC Silberman Steve, 2001, WIRED DEC Wheelwright S, 2001, AUTISM, V5, P223, DOI 10.1177/1362361301005002010 Windham GC, 2006, ENVIRON HEALTH PERSP, V114, P1438, DOI 10.1289/ehp.9120 Zhao X, 2007, P NATL ACAD SCI USA, V104, P12831, DOI 10.1073/pnas.0705803104 NR 19 TC 12 Z9 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2009 VL 2 IS 4 BP 183 EP 191 DI 10.1002/aur.84 PG 9 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 497AE UT WOS:000270022900001 PM 19606466 ER PT J AU Jellema, T Lorteije, J van Rijn, S van t' Wout, M de Haan, E van Engeland, H Kemner, C AF Jellema, Tjeerd Lorteije, Jeannette van Rijn, Sophie van t' Wout, Mascha de Haan, Edward van Engeland, Herman Kemner, Chantal TI Involuntary Interpretation of Social Cues is Compromised in Autism Spectrum Disorders SO AUTISM RESEARCH LA English DT Article DE social cognition; visual illusion; involuntary processing; social attention; implied motion ID SUPERIOR TEMPORAL SULCUS; IMPLIED MOTION; ASPERGER-SYNDROME; PERCEPTION; BRAIN; ATTENTION; COGNITION; GAZE; INTENTIONALITY; REPRESENTATION AB A new social distance judgment task was used to measure quantitatively the extent to which social cues are immediately and involuntary interpreted by typically developing (TD) individuals and by individuals with autism spectrum disorders (ASD). The task thus tapped into the ability to involuntary "pick up" the meaning of social cues. The cues tested were social attention and implied biological motion. Task performance of the ASD and TD groups was similarly affected by a perceptual low-level illusion induced by physical characteristics of the stimuli. In contrast, a high-level illusion induced by the implications of the social cues affected only the TD individuals; the ASD individuals remained unaffected (causing them to perform superior to TD controls). The results indicate that despite intact perceptual processing, the immediate involuntary interpretation of social cues can be compromised. We propose that this type of social cue understanding is a distinct process that should be differentiated from reflective social Cue understanding and is specifically compromised in ASD. We discuss evidence for an underpinning neural substrate. C1 [Jellema, Tjeerd] Univ Hull, Dept Psychol, Kingston Upon Hull HU6 7RX, East Yorkshire, England. [Lorteije, Jeannette] Erasmus Univ, Dept Neurosci, Rotterdam, Netherlands. [van Rijn, Sophie] Leiden Univ, Dept Clin Child & Adolescent Studies, Leiden, Netherlands. [van t' Wout, Mascha] Brown Univ, Dept Psychol, Providence, RI 02912 USA. [de Haan, Edward] Univ Amsterdam, Fac Social & Behav Sci, Amsterdam, Netherlands. [van Engeland, Herman] Univ Med Ctr Utrecht, Dept Child & Adolescent Psychiat, Utrecht, Netherlands. [Kemner, Chantal] Univ Utrecht, Dept Psychol, Utrecht, Netherlands. RP Jellema, T (reprint author), Univ Hull, Dept Psychol, Cottingham Rd, Kingston Upon Hull HU6 7RX, East Yorkshire, England. EM T.Jellema@hull.ac.uk CR Adams RB, 2005, EMOTION, V5, P3, DOI 10.1037/1528-3542.5.1.3 Adolphs R, 2001, CURR OPIN NEUROBIOL, V11, P231, DOI 10.1016/S0959-4388(00)00202-6 Adolphs R, 1999, TRENDS COGN SCI, V3, P469, DOI 10.1016/S1364-6613(99)01399-6 Allison T, 2000, TRENDS COGN SCI, V4, P267, DOI 10.1016/S1364-6613(00)01501-1 American Psychiatric Association, 1994, DIAGN STAT MAN MENT, V4th Bargh JA, 2006, EUR J SOC PSYCHOL, V36, P147, DOI 10.1002/ejsp.336 Bargh J.A., 2007, SOCIAL PSYCHOL UNCON Baron-Cohen S., 2005, ORIGINS SOCIAL MIND Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001 Bertone A, 2003, J COGNITIVE NEUROSCI, V15, P218, DOI 10.1162/089892903321208150 Blake R, 2003, PSYCHOL SCI, V14, P151, DOI 10.1111/1467-9280.01434 Brothers L., 1990, CONCEPTS NEUROSCIENC, V1, P27 Castelli F, 2002, BRAIN, V125, P1839, DOI 10.1093/brain/awf189 Dunbar RIM, 2007, SCIENCE, V317, P1344, DOI 10.1126/science.1145463 FREYD JJ, 1983, PERCEPT PSYCHOPHYS, V33, P575, DOI 10.3758/BF03202940 Frith CD, 1999, SCIENCE, V286, P1692, DOI 10.1126/science.286.5445.1692 Frith U., 1983, BRIT J DEV PSYCHOL, V1, P329, DOI 10.1111/j.2044-835X.1983.tb00906.x FRITH U, 1991, TRENDS NEUROSCI, V14, P433, DOI 10.1016/0166-2236(91)90041-R Frith U, 2001, NEURON, V32, P969, DOI 10.1016/S0896-6273(01)00552-9 GREGORY RL, 1963, NATURE, V199, P678, DOI 10.1038/199678a0 Happe F, 2006, J AUTISM DEV DISORD, V36, P5, DOI 10.1007/s10803-005-0039-0 Happe FGE, 1997, BRIT J DEV PSYCHOL, V15, P1 Haxby JV, 2002, BIOL PSYCHIAT, V51, P59, DOI 10.1016/S0006-3223(01)01330-0 Hietanen JK, 2003, J EXP PSYCHOL HUMAN, V29, P1228, DOI 10.1037/0096-1523.29.6.1228 Hietanen JK, 2002, PSYCHOL RES-PSYCH FO, V66, P174, DOI 10.1007/s00426-002-0091-8 Hobson R. P., 2002, CRADLE THOUGHT EXPLO Jellema T, 2003, NEUROPSYCHOLOGIA, V41, P1728, DOI 10.1016/S0028-3932(03)00175-1 Jellema T, 2000, BRAIN COGNITION, V44, P280, DOI 10.1006/brcg.2000.1231 Jellema T, 2007, OXFORD HDB EVOLUTION, DOI DOI 10.1093/oxfordhb/9780198568308.013.0013 Jellema T, 2002, ATTENTION PERFORM, V19, P356 KEMNER C, 2006, J CHILD PSYCHOL PSYC, V10, P1063 Klin A, 2000, J CHILD PSYCHOL PSYC, V41, P831, DOI 10.1017/S0021963099006101 Kourtzi Z, 2000, J COGNITIVE NEUROSCI, V12, P48, DOI 10.1162/08989290051137594 Langton SRH, 1999, VIS COGN, V6, P541 Lieberman MD, 2002, ADV EXP SOC PSYCHOL, V34, P199, DOI 10.1016/S0065-2601(02)80006-5 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lorteije JAM, 2006, J COGNITIVE NEUROSCI, V18, P158, DOI 10.1162/089892906775783732 Mitchell P, 2004, INFANT CHILD DEV, V13, P185, DOI 10.1002/icd.348 Pelphrey KA, 2004, J COGNITIVE NEUROSCI, V16, P1706, DOI 10.1162/0898929042947900 PERRETT DI, 1992, PHILOS T ROY SOC B, V335, P23, DOI 10.1098/rstb.1992.0003 PERRETT DI, 1999, BEHAV NEURAL MECH CO Reed CL, 1996, J EXP PSYCHOL HUMAN, V22, P839, DOI 10.1037/0096-1523.22.4.839 Rizzolatti G, 2004, ANNU REV NEUROSCI, V27, P169, DOI 10.1146/annurev.neuro.27.070203.144230 Ropar D, 1999, J CHILD PSYCHOL PSYC, V40, P1283, DOI 10.1017/S0021963099004667 Russell J., 1998, AUTISM EXECUTIVE DIS Sagiv N, 2001, J COGNITIVE NEUROSCI, V13, P937, DOI 10.1162/089892901753165854 Satpute AB, 2006, BRAIN RES, V1079, P86, DOI 10.1016/j.brainres.2006.01.005 Saxe R, 2004, NEUROPSYCHOLOGIA, V42, P1435, DOI 10.1016/j.neuropsychologia.2004.04.015 Scherf KS, 2008, AUTISM RES, V1, P114, DOI 10.1002/aur.17 Senju A, 2004, J CHILD PSYCHOL PSYC, V45, P445, DOI 10.1111/j.1469-7610.2004.00236.x Swettenham J, 2003, PHILOS T R SOC B, V358, P325, DOI 10.1098/rstb.2002.1203 Zilbovicius M, 2006, TRENDS NEUROSCI, V29, P359, DOI 10.1016/j.tins.2006.06.004 NR 53 TC 10 Z9 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-3792 EI 1939-3806 J9 AUTISM RES JI Autism Res. PD AUG PY 2009 VL 2 IS 4 BP 192 EP 204 DI 10.1002/aur.83 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 497AE UT WOS:000270022900002 PM 19642087 ER PT J AU Oblak, A Gibbs, TT Blatt, GJ AF Oblak, A. Gibbs, T. T. Blatt, G. J. TI Decreased GABA(A) Receptors and Benzodiazepine Binding Sites in the Anterior Cingulate Cortex in Autism SO AUTISM RESEARCH LA English DT Review DE autistic; anterior cingulate cortex; GABA; post-mortem; ligand binding ID TEMPORAL-LOBE EPILEPSY; POSITRON-EMISSION-TOMOGRAPHY; SPECTRUM DISORDERS; IN-VIVO; ALTERED EXPRESSION; PANIC DISORDER; LIMBIC CORTEX; THALAMIC CONNECTIONS; STATUS EPILEPTICUS; SUBUNIT GENES AB The anterior cingulate cortex (ACC; BA 24) via its extensive limbic and high order association cortical connectivity to prefrontal cortex is a key part of an important circuitry participating in executive function, affect, and socio-emotional behavior. Multiple lines of evidence, including genetic and imaging studies, suggest that the ACC and gamma-amino-butyric acid (GABA) system may be affected in autism. The benzodiazepine binding site on the GABA(A) receptor complex is an important target for pharmacotherapy and has important clinical implications. The present multiple-concentration ligand-binding study utilized H-3-muscimol and H-3-flunitrazepam to determine the number (B-max), binding affinity (K-d), and distribution of GABA(A) receptors and benzodiazepine binding sites, respectively, in the ACC in adult autistic and control cases. Compared to controls, the autistic group had significant decreases in the mean density of GABA(A) receptors in the supragranular (46.8%) and infragranular (20.2%) layers of the ACC and in the density of benzodiazepine binding sites in the supragranular (28.9%) and infragranular (16.40%) lamina. In addition, a trend for a decrease in for the density of benzodiazepine sites was found in the infragranular layers (17.1%) in the autism group. These findings Suggest that in the autistic group this downregulation of both benzodiazepine sites and GABA(A) receptors in the ACC may be the result of increased GABA innervation and/or release disturbing the delicate excitation/inhibition balance of principal neurons as well as their output to key limbic cortical targets. Such disturbances likely underlie the core alterations in socio-emotional behaviors in autism. C1 [Oblak, A.] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA. RP Oblak, A (reprint author), Boston Univ, Sch Med, Dept Anat & Neurobiol, 715 Albany St, Boston, MA 02118 USA. EM aoblak@bu.edu FU National Institutes of Health [NIH U54 MH66398]; NIH NINDS [NS38975] FX This work was supported by a "Studies to Advance Autism Research and Treatment" grants from the National Institutes of Health (NIH U54 MH66398) and NIH NINDS NS38975. Brain tissue was provided by the Harvard Brain Tissue Resource Center (HBTRC), the Autism Tissue Program, and the Autism Research Foundation. We thank Sandy Thevarkunnel for her help in receptor binding autoradiography methodology. CR Akerman CJ, 2007, TRENDS NEUROSCI, V30, P382, DOI 10.1016/j.tins.2007.06.002 Allman JM, 2001, ANN NY ACAD SCI, V935, P107 Ashley-Koch AE, 2006, ANN HUM GENET, V70, P281, DOI 10.1111/j.1469-1809.2006.00253.x Bailey A, 1998, BRAIN, V121, P889, DOI 10.1093/brain/121.5.889 Barker JL, 1998, PERSPECT DEV NEUROBI, V5, P305 BAUMAN M, 1985, NEUROLOGY, V35, P866 Belmonte MK, 2004, J NEUROSCI, V24, P9228, DOI 10.1523/JNEUROSCI.3340-04.2004 BELZUNG C, 1987, PHARMACOL BIOCHEM BE, V28, P29, DOI 10.1016/0091-3057(87)90006-2 Ben-Ari Y, 2007, PHYSIOL REV, V87, P1215, DOI 10.1152/physrev.00017.2006 BENES FM, 1992, J NEUROSCI, V12, P924 Blatt GJ, 2001, J AUTISM DEV DISORD, V31, P537, DOI 10.1023/A:1013238809666 Brooks-Kayal AR, 2009, NEUROTHERAPEUTICS, V6, P312, DOI 10.1016/j.nurt.2009.01.019 BURKHALTER A, 1989, J COMP NEUROL, V279, P171, DOI 10.1002/cne.902790202 Bush G, 2000, TRENDS COGN SCI, V4, P215, DOI 10.1016/S1364-6613(00)01483-2 Calzavara R, 2007, EUR J NEUROSCI, V26, P2005, DOI 10.1111/j.1460-9568.2007.05825.x Cameron OG, 2007, ARCH GEN PSYCHIAT, V64, P793, DOI 10.1001/archpsyc.64.7.793 Cancedda L, 2007, J NEUROSCI, V27, P5224, DOI 10.1523/JNEUROSCI.5169-06.2007 Casanova MF, 2002, NEUROLOGY, V58, P428 Casanova MF, 2006, CLIN NEUROSCI RES, V6, P127, DOI 10.1016/j.cnr.2006.06.003 Casanova MF, 2003, NEUROSCIENTIST, V9, P496, DOI 10.1177/1073858403253552 Conti F, 2004, BRAIN RES REV, V45, P196, DOI 10.1016/j.brainsrev.2004.03.003 Corfas G, 2004, NAT NEUROSCI, V7, P575, DOI 10.1038/nn1258 Dalvi A, 1996, PSYCHOPHARMACOLOGY, V128, P380, DOI 10.1007/s002130050148 DEVINSKY O, 1995, BRAIN, V118, P279, DOI 10.1093/brain/118.1.279 Di Cristo G, 2007, CLIN GENET, V72, P1, DOI 10.1111/j.1399-0004.2007.00822.x Fatemi SH, 2009, CEREBELLUM, V8, P64, DOI 10.1007/s12311-008-0075-3 Fatemi SH, 2002, BIOL PSYCHIAT, V52, P805, DOI 10.1016/S0006-3223(02)01430-0 Fatemi SH, 2009, J AUTISM DEV DISORD, V39, P223, DOI 10.1007/s10803-008-0646-7 Fritschy JM, 1997, NEUROSCIENCE, V81, P1043, DOI 10.1016/S0306-4522(97)00244-3 Gilby KL, 2005, EPILEPSIA, V46, P3, DOI 10.1111/j.1528-1167.2005.01001.x GILLBERG C, 1987, DEV MED CHILD NEUROL, V29, P641 Gillott A, 2001, AUTISM, V5, P277, DOI 10.1177/1362361301005003005 Gillott Alinda, 2007, J Intellect Disabil, V11, P359, DOI 10.1177/1744629507083585 Guptill JT, 2007, J AUTISM DEV DISORD, V37, P911, DOI 10.1007/s10803-006-0226-7 Hasler G, 2008, ARCH GEN PSYCHIAT, V65, P1166, DOI 10.1001/archpsyc.65.10.1166 Haznedar MM, 2000, AM J PSYCHIAT, V157, P1994, DOI 10.1176/appi.ajp.157.12.1994 Haznedar MM, 1997, AM J PSYCHIAT, V154, P1047 Heck N, 2007, CEREB CORTEX, V17, P138, DOI 10.1093/cercor/bhj135 Heimer L, 2006, NEUROSCI BIOBEHAV R, V30, P126, DOI 10.1016/j.neubiorev.2005.06.006 Isomura Y, 2004, REV NEUROSCIENCE, V15, P279 Juranek J, 2006, J CHILD NEUROL, V21, P1051, DOI 10.2310/7010.2006.00237 KAITZ SS, 1981, J COMP NEUROL, V195, P527, DOI 10.1002/cne.901950309 Kalanithi PSA, 2005, P NATL ACAD SCI USA, V102, P13307, DOI 10.1073/pnas.0502624102 Kana RK, 2006, BRAIN, V129, P2484, DOI 10.1093/brain/awl164 Kana RK, 2007, BIOL PSYCHIAT, V62, P198, DOI 10.1016/j.biopsych.2006.08.004 Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103 KUUSIKKO S, 2008, J AUTISM DEV DISORD, V9, P1697 Lane RD, 1998, J COGNITIVE NEUROSCI, V10, P525, DOI 10.1162/089892998562924 LAWRENCE YA, 2009, ACTA NEUROL IN PRESS Li HF, 2006, NEUROPHARMACOLOGY, V51, P121, DOI 10.1016/j.neuropharm.2006.03.003 Loup F, 2000, J NEUROSCI, V20, P5401 Loup F, 2006, BRAIN, V129, P3277, DOI 10.1093/brain/awl287 Low K, 2000, SCIENCE, V290, P131, DOI 10.1126/science.290.5489.131 Ma DQ, 2005, AM J HUM GENET, V77, P377, DOI 10.1086/433195 Marrosu F, 1987, Funct Neurol, V2, P355 Matheja P, 2001, J NEUROL, V248, P585, DOI 10.1007/s004150170136 Meng HY, 2005, P NATL ACAD SCI USA, V102, P17053, DOI 10.1073/pnas.0508591102 MOHLER H, 1995, ADV BIOCHEM PSYCHOPH, V48, P41 Mohler H, 2004, BIOCHEM PHARMACOL, V68, P1685, DOI 10.1016/j.bcp.2004.07.025 MOHLER H, 1995, NEUROCHEM RES, V20, P631, DOI 10.1007/BF01694546 Morris HV, 2006, EUR J NEUROSCI, V23, P2495, DOI 10.1111/j.1460-9568.2006.04775.x Nieuwenhuis S, 2003, COGN AFFECT BEHAV NE, V3, P17, DOI 10.3758/CABN.3.1.17 Nishimura T, 2005, NEUROSCIENCE, V134, P691, DOI 10.1016/j.neuroscience.2005.04.013 OLSSON I, 1988, ARCH NEUROL-CHICAGO, V45, P666 Oswald DP, 2007, J CHILD ADOL PSYCHOP, V17, P348, DOI 10.1089/cap.2006.17303 PANDYA DN, 1981, EXP BRAIN RES, V42, P319 Papez JW, 1937, ARCH NEURO PSYCHIATR, V38, P725 Peng ZC, 2004, J NEUROSCI, V24, P8629, DOI 10.1523/JNEUROSCI.2877-04.2004 Petrides M, 2007, J NEUROSCI, V27, P11573, DOI 10.1523/JNEUROSCI.2419-07.2007 PORRINO LJ, 1981, J COMP NEUROL, V198, P121, DOI 10.1002/cne.901980111 Posner MI, 2007, COGN AFFECT BEHAV NE, V7, P391, DOI 10.3758/CABN.7.4.391 Posner MI, 1999, ZH VYSSH NERV DEYAT+, V49, P715 RAINNIE DG, 1992, J NEUROPHYSIOL, V67, P443 Roberts DS, 2005, P NATL ACAD SCI USA, V102, P11894, DOI 10.1073/pnas.0501434102 ROBERTSON RT, 1981, J COMP NEUROL, V195, P501, DOI 10.1002/cne.901950308 Rockland KS, 1996, J COMP NEUROL, V373, P529 RoyByrne P, 1996, AM J PSYCHIAT, V153, P1444 Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Rutter M, 1970, Spec Educ, V59, P20 SAVIC I, 1988, LANCET, V2, P863 Schmitz N, 2008, BRIT J PSYCHIAT, V192, P19, DOI 10.1192/bjp.bp.107.036921 Schroer RJ, 1998, AM J MED GENET, V76, P327, DOI 10.1002/(SICI)1096-8628(19980401)76:4<327::AID-AJMG8>3.0.CO;2-M Schumann CM, 2006, J NEUROSCI, V26, P7674, DOI 10.1523/JNEUROSCI.1285-06.2006 Shafritz KM, 2008, BIOL PSYCHIAT, V63, P974, DOI 10.1016/j.biopsych.2007.06.028 Silk TJ, 2006, AM J PSYCHIAT, V163, P1440, DOI 10.1176/appi.ajp.163.8.1440 SIMMS ML, 2009, ACTA NEUROP IN PRESS SPETH RC, 1980, FED PROC, V39, P3032 Sukhodolsky DG, 2008, J ABNORM CHILD PSYCH, V36, P117, DOI 10.1007/s10802-007-9165-9 Sundstrom I, 1997, PSYCHONEUROENDOCRINO, V22, P25, DOI 10.1016/S0306-4530(96)00035-2 Thakkar KN, 2008, BRAIN, V131, P2464, DOI 10.1093/brain/awn099 Thomson AM, 2002, CEREB CORTEX, V12, P936, DOI 10.1093/cercor/12.9.936 Towbin KE, 2005, J CHILD ADOL PSYCHOP, V15, P452, DOI 10.1089/cap.2005.15.452 VOGT BA, 1987, J COMP NEUROL, V262, P271, DOI 10.1002/cne.902620208 Vogt Brent A., 1992, Cerebral Cortex, V2, P435, DOI 10.1093/cercor/2.6.435 VOGT BA, 1995, J COMP NEUROL, V359, P490, DOI 10.1002/cne.903590310 VOLKMAR FR, 1990, J AM ACAD CHILD PSY, V29, P127, DOI 10.1097/00004583-199001000-00020 Vollm BA, 2006, NEUROIMAGE, V29, P90, DOI 10.1016/j.neuroimage.2005.07.022 WEIZMAN A, 1989, EUR J PHARMACOL, V169, P235, DOI 10.1016/0014-2999(89)90020-4 YAKOVLEV PI, 1961, ARCH NEUROL-CHICAGO, V5, P364 Yip J, 2007, ACTA NEUROPATHOL, V113, P559, DOI 10.1007/s00401-006-0176-3 Yip J, 2008, J NEUROSCI RES, V86, P525, DOI 10.1002/jnr.21520 Yip J, 2009, AUTISM RES, V2, P50, DOI 10.1002/aur.62 Zhuo M, 2006, J NEUROSCI RES, V84, P927, DOI 10.1002/jnr.21003 NR 103 TC 51 Z9 51 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2009 VL 2 IS 4 BP 205 EP 219 DI 10.1002/aur.88 PG 15 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 497AE UT WOS:000270022900003 PM 19650112 ER PT J AU Hasson, U Avidan, G Gelbard, H Vallines, I Harel, M Minshew, N Behrmann, M AF Hasson, Uri Avidan, Galia Gelbard, Hagar Vallines, Ignacio Harel, Michal Minshew, Nancy Behrmann, Marlene TI Shared and Idiosyncratic Cortical Activation Patterns in Autism Revealed Under Continuous Real-Life Viewing Conditions SO AUTISM RESEARCH LA English DT Article DE autism; inter-subject correlation; functional magnetic resonance imaging (fMRI); hyperconnectivity ID SPECTRUM DISORDERS; INTERSUBJECT CORRELATIONS; DEVELOPMENTAL DISORDERS; BRAIN; CORTEX; ABNORMALITIES; CHILDREN; FMRI; ORGANIZATION; INDIVIDUALS AB Although widespread alterations in cortical structure have been documented in individuals with autism, the functional implications of these alterations remain to be determined. Here, we adopted a novel inter-subject correlation (inter-SC) and intra-subject correlation (intra-SC) technique to quantify the reliability of the spatio-temporal responses of functional MR activity in adults with autism during free-viewing of a popular audio-visual movie. Whereas these complex stimuli evoke highly reliable shared response time courses in typical individuals, cortical activity was more variable across individuals with autism (low inter-SC). Interestingly, when we measured the responses within an autistic individual across repeated presentations of the movie, we observed a unique, idiosyncratic response time course that was reliably replicated within each individual (high intra-SC). Encouragingly, after filtering out the idiosyncratic responses from each individual time course, we were able to uncover a more typical response profile, which resembles the shared responses seen in the typical subjects. These findings indicate that, under conditions approximating real-life situations, the neural activity of individuals with autism is characterized by individualistic responses that, although reliable within an autistic individual, are both highly variable across autistic individuals and different from the responses observed within the typical subjects. These idiosyncratic responses may underlie the atypical behaviors observed in autism. At the same time, we are encouraged by the presence of the more typical activation pattern lurking beneath these idiosyncratic fluctuations. Taken together, these findings may pave the way to future research aimed at characterizing the idiosyncratic response profiles, which, in turn, might contribute to a better understanding of the heterogeneity of the autism spectrum and its diagnosis. C1 [Hasson, Uri] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA. [Hasson, Uri] Princeton Univ, Inst Neurosci, Princeton, NJ 08544 USA. [Avidan, Galia] Ben Gurion Univ Negev, Dept Psychol, IL-84105 Beer Sheva, Israel. [Gelbard, Hagar; Harel, Michal] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel. [Vallines, Ignacio] Univ Regensburg, Inst Expt Psychol, D-8400 Regensburg, Germany. [Minshew, Nancy] Univ Pittsburgh, Sch Med, Dept Psychiat & Neurol, Pittsburgh, PA USA. [Behrmann, Marlene] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA. RP Hasson, U (reprint author), Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA. EM hasson@princeton.edu RI Avidan, Galia/B-9347-2011; Galbard-Sagiv, Hagar/J-8482-2014 OI Galbard-Sagiv, Hagar/0000-0003-0379-3854 FU International Human Frontier Science Program Organization long-term fellowship; NICHD/NIDCD [PO1/U19] FX Special thanks to Rafael Malach for his valuable input to this project. We thank David Heeger, Nava Rubin, Ifat Levy, Kate Humphreys, Cibu Thomas, Nava Levit-Binnun, and Yoram Bonneh for fruitful discussions and comments on the manuscript. Funding was provided by an International Human Frontier Science Program Organization long-term fellowship (U. H.) and NICHD/NIDCD PO1/U19 (M. B. and N. M.), which is part of the NICHD/NIDCD Collaborative programs for Excellence in Autism. We thank Grace Lee Leonard, Lauren Lorenzi, and Stacy Cho for assistance in data collection and the individuals at the Collaborative Program for Excellence in Autism research at the University of Pittsburgh for their help in recruiting, scheduling, and testing Subjects. CR Amaral DG, 2008, TRENDS NEUROSCI, V31, P137, DOI 10.1016/j.tins.2007.12.005 Bachevalier J, 2006, NEUROSCI BIOBEHAV R, V30, P97, DOI 10.1016/j.neubiorev.2005.07.002 Barnea-Goraly N, 2004, BIOL PSYCHIAT, V55, P323, DOI 10.1016/j.biopsych.2003.10.022 Baron-Cohen S, 2005, ANNU REV NEUROSCI, V28, P109, DOI 10.1146/annurev.neuro.27.070203.144137 Behrmann M, 2006, TRENDS COGN SCI, V10, P258, DOI 10.1016/j.tics.2006.05.001 Belmonte MK, 2004, MOL PSYCHIATR, V9, P646, DOI 10.1038/sj.mp.4001499 Cody H, 2002, INT J DEV NEUROSCI, V20, P421, DOI 10.1016/S0736-5748(02)00053-9 Courchesne E, 2001, NEUROLOGY, V57, P245 Crane L, 2009, AUTISM, V13, P215, DOI 10.1177/1362361309103794 Dakin S, 2005, NEURON, V48, P497, DOI 10.1016/j.neuron.2005.10.018 Dalton KM, 2005, NAT NEUROSCI, V8, P519, DOI 10.1038/nn1421 Daoust AM, 2004, CLIN NEUROPHYSIOL, V115, P1368, DOI 10.1016/j.clinph.2004.01.011 Deary IJ, 1997, INTELLIGENCE, V24, P461, DOI 10.1016/S0160-2896(97)90060-X Freitag CM, 2009, BIOL PSYCHIAT, V66, P316, DOI 10.1016/j.biopsych.2009.03.011 Frith U, 2005, CURR BIOL, V15, pR786, DOI 10.1016/j.cub.2005.09.033 Geurts HM, 2008, NEUROPSYCHOLOGIA, V46, P3030, DOI 10.1016/j.neuropsychologia.2008.06.013 Golland Y, 2007, CEREB CORTEX, V17, P766, DOI 10.1093/cercor/bhk030 Hadjikhani N, 2004, NEUROREPORT, V15, P267, DOI 10.1097/01.wnr.0000107523.38715.fa Hanson SJ, 2009, J COMPUT NEUROSCI, V27, P103, DOI 10.1007/s10827-008-0129-z Hasson U, 2003, NEURON, V37, P1027, DOI 10.1016/S0896-6273(03)00144-2 Hasson U, 2008, J NEUROSCI, V28, P2539, DOI 10.1523/JNEUROSCI.5487-07.2008 Hasson U, 2008, NEURON, V57, P452, DOI 10.1016/j.neuron.2007.12.009 Hasson U, 2004, SCIENCE, V303, P1634, DOI 10.1126/science.1089506 Hendry J, 2006, NEUROIMAGE, V29, P1049, DOI 10.1016/j.neuroimage.2005.08.039 Herbert MR, 2005, NEUROSCIENTIST, V11, P417, DOI 10.1177/0091270005278866 Herbert MR, 2004, ANN NEUROL, V55, P530, DOI 10.1002/ana.20032 Hrdlicka M, 2008, NEUROENDOCRINOL LETT, V29, P281 Hughes JR, 2005, CLIN EEG NEUROSCI, V36, P15 Humphreys K, 2008, AUTISM RES, V1, P52, DOI 10.1002/aur.1 Hurley RA, 2000, J NEUROPSYCH CLIN N, V12, P1 Jaaskelainen P.I., 2008, OPEN NEUROIMAGING J, V2, P14 Kennedy DP, 2006, P NATL ACAD SCI USA, V103, P8275, DOI 10.1073/pnas.0600674103 Kennedy DP, 2008, NEUROIMAGE, V39, P1877, DOI 10.1016/j.neuroimage.2007.10.052 Kleinhans NM, 2008, BRAIN, V131, P1000, DOI 10.1093/brain/awm334 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 Klin A, 2002, AM J PSYCHIAT, V159, P895, DOI 10.1176/appi.ajp.159.6.895 Logothetis NK, 2001, NATURE, V412, P150, DOI 10.1038/35084005 LORD C, 1994, J AUTISM DEV DISORD, V24, P659, DOI 10.1007/BF02172145 Lord C, 2000, NEURON, V28, P355, DOI 10.1016/S0896-6273(00)00115-X Luna B, 2002, NEUROLOGY, V59, P834 Markram Henry, 2007, Front Neurosci, V1, P77, DOI 10.3389/neuro.01.1.1.006.2007 McAlonan GM, 2005, BRAIN, V128, P268, DOI 10.1093/brain/awh332 Morris JP, 2007, SOC COGN AFFECT NEUR, V2, P31, DOI 10.1093/scan/nsl023 Mukamel R, 2005, SCIENCE, V309, P951, DOI 10.1126/science.1110913 Pelphrey KA, 2005, BRAIN, V128, P1038, DOI 10.1093/brain/awh404 Peterson CC, 2005, CHILD DEV, V76, P502, DOI 10.1111/j.1467-8624.2005.00859.x Pierce K, 2001, BRAIN, V124, P2059, DOI 10.1093/brain/124.10.2059 Polleux F, 2004, MENT RETARD DEV D R, V10, P303, DOI 10.1002/mrdd.20044 Ristic J, 2005, COGNITIVE BRAIN RES, V24, P715, DOI 10.1016/j.cogbrainres.2005.02.007 Rogers SJ, 2003, J CHILD PSYCHOL PSYC, V44, P763, DOI 10.1111/1469-7610.00162 Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1046/j.1601-183X.2003.00037.x Schultz RT, 2000, ARCH GEN PSYCHIAT, V57, P331, DOI 10.1001/archpsyc.57.4.331 Talairach J., 1988, COPLANAR STEREOTAXIC Tuchman R, 2000, J AUTISM DEV DISORD, V30, P485, DOI 10.1023/A:1005572128200 Vandenbroucke MWG, 2008, BRAIN, V131, P1013, DOI 10.1093/brain/awm321 Williams DL, 2006, CHILD NEUROPSYCHOL, V12, P279, DOI 10.1080/09297040600681190 Wilson SM, 2008, CEREB CORTEX, V18, P230, DOI 10.1093/cercor/bhm049 NR 57 TC 26 Z9 27 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2009 VL 2 IS 4 BP 220 EP 231 DI 10.1002/aur.89 PG 12 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 497AE UT WOS:000270022900004 PM 19708061 ER PT J AU Jackson, PB Boccuto, L Skinner, C Collins, JS Neri, G Gurrieri, F Schwartz, CE AF Jackson, Pamela B. Boccuto, Luigi Skinner, Cindy Collins, Julianne S. Neri, Giovanni Gurrieri, Fiorella Schwartz, Charles E. TI Further Evidence that the rs1858830 C Variant in the Promoter Region of the MET Gene is Associated with Autistic Disorder SO AUTISM RESEARCH LA English DT Article DE autism; autistic disorder; MET; PDD; PDD-NOS ID GROWTH FACTOR/SCATTER FACTOR; INTERNEURON DEVELOPMENT; SPECTRUM DISORDER; GENOMIC SCREEN; CHROMOSOME 7Q; ETIOLOGY; PROTOONCOGENE; DISRUPTION; EPILEPSY; FAMILY AB Previous studies in three independent cohorts have shown that the rs1858830 C allele variant in the promoter region of the MET gene on chromosome 7q31 is associated with autism. Another study has found correlations between other alterations in the MET gene and autism in two unrelated cohorts. This study screened two cohorts, an Autistic Disorder cohort from South Carolina and a Pervasive Developmental Disorder (PDD) cohort from Italy, for the presence of the C allele variant in rs1858830. A significant increase in the C allele variant frequency was found in the South Carolina Autistic Disorder patients as compared to South Carolina Controls (chi(2) = 5.8, df = 1, P = 0.02). In the South Carolina cohort, a significant association with Autistic Disorder was found when comparing the CC and CG genotypes to the GG genotype (odds ratio (OR) = 1.64; 95% confidence interval (CI) = 1.12-2.40; chi(2) = 6.5, df = 1, P = 0.01) in cases and controls. In the Italian cohort, no significant association with PDD was found when comparing the CC or CG genotype to the GG genotype (OR = 1.20; 95% CI = 0.56-2.56; chi(2) = 0.2, df = 1, P = 0.64). This study is the third independent study to find the rs1858830 C variant in the MET gene promoter to be associated with autism. C1 [Jackson, Pamela B.; Boccuto, Luigi; Skinner, Cindy; Collins, Julianne S.; Schwartz, Charles E.] Greenwood Genet Ctr, JC Self Res Inst Human Genet, Greenwood, SC 29646 USA. [Jackson, Pamela B.; Collins, Julianne S.; Schwartz, Charles E.] Clemson Univ, Dept Biochem & Genet, Clemson, SC USA. [Boccuto, Luigi; Neri, Giovanni; Gurrieri, Fiorella] Catholic Univ, Inst Med Genet, Rome, Italy. RP Schwartz, CE (reprint author), Greenwood Genet Ctr, JC Self Res Inst Human Genet, 113 Gregor Mendel Circle, Greenwood, SC 29646 USA. EM ceschwartz@ggc.org FU South Carolina Department of Disabilities and Special Needs FX We express our gratitude to the patients and to their families for their cooperation during this project. This article was supported by work undertaken as a part of a general study of autism initiated by the Greenwood Genetic Center with partial funding by a grant from the South Carolina Department of Disabilities and Special Needs. The authors of this paper thank Debbie Mader and Sara Sarasua for their assistance during this project. CR Ashley-Koch A, 1999, GENOMICS, V61, P227, DOI 10.1006/geno.1999.5968 Barrett S, 1999, AM J MED GENET, V88, P609 Bauman ML, 2005, INT J DEV NEUROSCI, V23, P183, DOI 10.1016/j.ijdevneu.2004.09.006 Blume-Jensen P, 2001, NATURE, V411, P355, DOI 10.1038/35077225 Campbell DB, 2006, P NATL ACAD SCI USA, V103, P16834, DOI 10.1073/pnas.0605296103 Campbell DB, 2007, ANN NEUROL, V62, P243, DOI 10.1002/ana.21180 Campbell DB, 2008, AUTISM RES, V1, P159, DOI 10.1002/aur.27 Folstein SE, 2001, NAT REV GENET, V2, P943, DOI 10.1038/35103559 Folstein SE, 2000, AM J HUM GENET, V67, P278, DOI 10.1086/303034 Fombonne E, 1999, PSYCHOL MED, V29, P769, DOI 10.1017/S0033291799008508 Gherardi E, 2003, P NATL ACAD SCI USA, V100, P12039, DOI 10.1073/pnas.2034936100 Gutknecht L, 2001, BEHAV GENET, V31, P113, DOI 10.1023/A:1010218227600 Herba CM, 2008, J AUTISM DEV DISORD, V38, P706, DOI 10.1007/s10803-007-0438-5 Horvath S, 2001, EUR J HUM GENET, V9, P301, DOI 10.1038/sj.ejhg.5200625 IERCI A, 2002, P NATL ACAD SCI USA, V99, P15200 Bailey A, 1998, HUM MOL GENET, V7, P571 LAMB JA, 2005, J MED GENET, V42, P32 Levitt P, 2004, TRENDS NEUROSCI, V27, P400, DOI 10.1016/j.tins.2004.05.008 Muhle R, 2004, PEDIATRICS, V113, pE472, DOI 10.1542/peds.113.5.e472 PARK M, 1987, P NATL ACAD SCI USA, V84, P6379, DOI 10.1073/pnas.84.18.6379 Philippe A, 1999, HUM MOL GENET, V8, P805, DOI 10.1093/hmg/8.5.805 Powell EM, 2001, NEURON, V30, P79, DOI 10.1016/S0896-6273(01)00264-1 Powell EM, 2003, J NEUROSCI, V23, P622 Risch N, 1999, AM J HUM GENET, V65, P493, DOI 10.1086/302497 Rutter M, 2005, J INTELL DISABIL RES, V49, P231, DOI 10.1111/j.1365-2788.2005.00676.x Schellenberg GD, 2006, MOL PSYCHIATR, V11, P1049, DOI 10.1038/sj.mp.4001874 Schroer RJ, 1998, AM J MED GENET, V76, P327, DOI 10.1002/(SICI)1096-8628(19980401)76:4<327::AID-AJMG8>3.0.CO;2-M Sousa I, 2009, EUR J HUM GENET, V17, P749, DOI 10.1038/ejhg.2008.215 Tahara Y, 2003, J PHARMACOL EXP THER, V307, P146, DOI 10.1124/jpet.103.054106 Trikalinos TA, 2006, MOL PSYCHIATR, V11, P29, DOI 10.1038/sj.mp.4001750 Tuchman R, 2002, LANCET NEUROL, V1, P352, DOI 10.1016/S1474-4422(02)00160-6 Veenstra-VanderWeele J, 2004, MOL PSYCHIATR, V9, P819, DOI 10.1038/sj.mp.4001505 Vincent JB, 2000, AM J HUM GENET, V67, P510, DOI 10.1086/303005 Yeargin-Allsopp M, 2003, JAMA-J AM MED ASSOC, V289, P49, DOI 10.1001/jama.289.1.49 NR 34 TC 29 Z9 30 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2009 VL 2 IS 4 BP 232 EP 236 DI 10.1002/aur.87 PG 5 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 497AE UT WOS:000270022900005 PM 19681062 ER PT J AU Cook, EH AF Cook, Edwin H., Jr. TI Literature Review: Citalopram Efficacy Study; Interstitial 15q11-q13 Duplication Mouse SO AUTISM RESEARCH LA English DT Review ID AUTISTIC DISORDER; DOUBLE-BLIND; BEHAVIOR; PLACEBO C1 Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA. RP Cook, EH (reprint author), Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60608 USA. EM ecook@psych.uic.edu CR Dolen G, 2007, NEURON, V56, P955, DOI 10.1016/j.neuron.2007.12.001 GORDON CT, 1993, ARCH GEN PSYCHIAT, V50, P441 Kanner L, 1943, NERV CHILD, V2, P217 King BH, 2009, ARCH GEN PSYCHIAT, V66, P583, DOI 10.1001/archgenpsychiatry.2009.30 McDougle CJ, 1996, ARCH GEN PSYCHIAT, V53, P1001 Nakatani J, 2009, CELL, V137, P1235, DOI 10.1016/j.cell.2009.04.024 Owley T, 2005, J AM ACAD CHILD PSY, V44, P343, DOI 10.1097/01.chi.0000153229.80215.a0 NR 7 TC 0 Z9 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD AUG PY 2009 VL 2 IS 4 BP 238 EP 240 DI 10.1002/aur.94 PG 3 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 497AE UT WOS:000270022900007 ER PT J AU Rogers, SJ AF Rogers, Sally J. TI What are Infant Siblings Teaching Us About Autism in Infancy? SO AUTISM RESEARCH LA English DT Review ID SPECTRUM DISORDERS; YOUNGER SIBLINGS; PHENOTYPE; CHILDREN; SPEECH; RISK; COMMUNICATION; 1ST; DISENGAGEMENT; BEHAVIORS AB International research to understand infant patterns of development in autism spectrum disorders (ASDs) has recently focused on a research paradigm involving prospective longitudinal studies of infant siblings of children with autism. Such designs use a comparison group of infant siblings without any familial risks (the low-risk group) to gather longitudinal information about developmental skills across the first 3 years of life, followed by clinical diagnosis of ASD at 36 months. This review focuses on five topics: presence of ASD in the infant sibling groups, patterns and characteristics of motor development, patterns and characteristics of social and emotional development, patterns and characteristics of intentional communication, both verbal and nonverbal, and patterns that mark the onset of behaviors pathognomonic for ASD. Symptoms in all these areas typically begin to be detected during the age period of 12-24 months in infants who will develop autism. Onset of the symptoms occurs at varying ages and in varying patterns, but the pattern of frank loss of skills and marked regression reported from previous retrospective studies in 20-30% of children is seldom reported in these infant sibling prospective studies. Two surprises involve the very early onset of repetitive and unusual sensory behaviors, and the lack of predictive symptoms at the age of 6 months. Contrary to current views that autism is a disorder that profoundly affects social development from the earliest months of life, the data from these studies presents a picture of autism as a disorder involving symptoms across multiple domains with a gradual onset that changes both ongoing developmental rate and established behavioral patterns across the first 2-3 years of life. C1 [Rogers, Sally J.] Univ Calif Davis, MIND Inst, Sacramento, CA 95817 USA. RP Rogers, SJ (reprint author), Univ Calif Davis, MIND Inst, Davis, CA 95616 USA. EM sally.rogers@ucdmc.ucdavis.edu FU NIH [R01 MH081757, MH068398] FX Grant sponsor: NIH; Grant numbers: R01 MH081757; MH068398. CR ADRIEN JL, 1991, J AUTISM DEV DISORD, V21, P43, DOI 10.1007/BF02206996 Bailey A, 1998, J AUTISM DEV DISORD, V28, P369, DOI 10.1023/A:1026048320785 Baranek GT, 1999, J AUTISM DEV DISORD, V29, P213, DOI 10.1023/A:1023080005650 BARONCOHEN S, 1992, BRIT J PSYCHIAT, V161, P839, DOI 10.1192/bjp.161.6.839 Brian J, 2008, AUTISM, V12, P433, DOI 10.1177/1362361308094500 Bryson SE, 2007, J AUTISM DEV DISORD, V37, P12, DOI 10.1007/s10803-006-0328-2 BRYSON SE, 2006, J AUTISM DEV DISORD, V38, P731 Cassel TD, 2007, J AUTISM DEV DISORD, V37, P122, DOI 10.1007/s10803-006-0337-1 Constantino JN, 2003, ARCH GEN PSYCHIAT, V60, P524, DOI 10.1001/archpsyc.60.5.524 COOPER RP, 1990, CHILD DEV, V61, P1584, DOI 10.1111/j.1467-8624.1990.tb02885.x Dawson G, 2002, DEV PSYCHOPATHOL, V14, P581, DOI 10.1017/S0954579402003103 Elsabbagh M, 2009, J CHILD PSYCHOL PSYC, V50, P637, DOI 10.1111/j.1469-7610.2008.02051.x Elsabbagh M, 2007, PROG BRAIN RES, V164, P355, DOI 10.1016/S0079-6123(07)64020-5 Elsabbagh M, 2009, BIOL PSYCHIAT, V65, P31, DOI 10.1016/j.biopsych.2008.09.034 Gamliel I, 2007, J AUTISM DEV DISORD, V37, P171, DOI 10.1007/s10803-006-0341-5 Garon N, 2009, J ABNORM CHILD PSYCH, V37, P59, DOI 10.1007/s10802-008-9258-0 Goldberg WA, 2005, J AUTISM DEV DISORD, V35, P657, DOI 10.1007/s10803-005-0009-6 Ibanez LV, 2008, AUTISM, V12, P473, DOI 10.1177/1362361308094504 Iverson JM, 2007, J AUTISM DEV DISORD, V37, P158, DOI 10.1007/s10803-006-0339-z Kagan J, 2008, CHILD DEV, V79, P1606, DOI 10.1111/j.1467-8624.2008.01211.x Kanner L, 1943, NERV CHILD, V2, P217 KLIN A, 1991, J AUTISM DEV DISORD, V21, P29, DOI 10.1007/BF02206995 Klin A, 2002, ARCH GEN PSYCHIAT, V59, P809, DOI 10.1001/archpsyc.59.9.809 Kuhl P. K., 2005, DEVELOPMENTAL SCI, V8, P1, DOI [DOI 10.1111/J.1467-7687.2004.00384.X, 10.1111/j.1467-7687.2004.00384.x] Landa R, 2006, J CHILD PSYCHOL PSYC, V47, P629, DOI 10.1111/j.1469-7610.2006.01531.x Landa RJ, 2007, ARCH GEN PSYCHIAT, V64, P853, DOI 10.1001/archpsyc.64.7.853 Liu HM, 2003, DEVELOPMENTAL SCI, V6, pF1, DOI 10.1111/1467-7687.00275 Loh A, 2007, J AUTISM DEV DISORD, V37, P25, DOI 10.1007/s10803-006-0333-5 McCleery JP, 2007, BIOL PSYCHIAT, V62, P1007, DOI 10.1016/j.biopsych.2007.02.009 Merin N, 2007, J AUTISM DEV DISORD, V37, P108, DOI 10.1007/s10803-006-0342-4 Micali N, 2004, AUTISM, V8, P21, DOI 10.1177/1362361304040636 Mundy P, 2007, CHILD DEV, V78, P938, DOI 10.1111/j.1467-8624.2007.01042.x Nadig AS, 2007, ARCH PEDIAT ADOL MED, V161, P378, DOI 10.1001/archpedi.161.4.378 OSTERLING J, 1994, J AUTISM DEV DISORD, V24, P247, DOI 10.1007/BF02172225 Ozonoff S, 2008, AUTISM, V12, P457, DOI 10.1177/1362361308096402 Ozonoff S, 2008, AUTISM RES, V1, P320, DOI 10.1002/aur.53 Presmanes AG, 2007, J AUTISM DEV DISORD, V37, P133, DOI 10.1007/s10803-006-0338-0 Skuse DH, 2001, BRIT J PSYCHIAT, V178, P395, DOI 10.1192/bjp.178.5.395 Stone WL, 2007, ARCH PEDIAT ADOL MED, V161, P384, DOI 10.1001/archpedi.161.4.384 Sullivan M, 2007, J AUTISM DEV DISORD, V37, P37, DOI 10.1007/s10803-006-0335-3 THELEN E, 1979, ANIM BEHAV, V27, P699, DOI 10.1016/0003-3472(79)90006-X Toth K, 2007, J AUTISM DEV DISORD, V37, P145, DOI 10.1007/s10803-006-0336-2 TRONICK E, 1978, J AM ACAD CHILD PSY, V17, P1, DOI 10.1016/S0002-7138(09)62273-1 Tsao FM, 2004, CHILD DEV, V75, P1067, DOI 10.1111/j.1467-8624.2004.00726.x Vismara LA, 2008, J EARLY INTERVENTION, V31, P91, DOI 10.1177/1053815108325578 Yirmiya N, 2007, J AUTISM DEV DISORD, V37, P1, DOI 10.1007/s10803-006-0329-1 Yirmiya N, 2006, J CHILD PSYCHOL PSYC, V47, P511, DOI 10.1111/j.1469-7610.2005.01528.x YODER P, 2009, J AUTISM DEV DISORD, DOI DOI 10.1007/210803-009-0753-0 YOUNG GS, 2009, DEV SCI IN PRESS, DOI DOI 10.1111/J.1407-7687.2009.0083.X Zwaigenbaum L, 2005, INT J DEV NEUROSCI, V23, P143, DOI 10.1016/j.ijdevneu.2004.05.001 NR 50 TC 113 Z9 114 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1939-3792 J9 AUTISM RES JI Autism Res. PD JUN PY 2009 VL 2 IS 3 BP 125 EP 137 DI 10.1002/aur.81 PG 13 WC Behavioral Sciences; Psychology, Developmental SC Behavioral Sciences; Psychology GA 497SS UT WOS:000270083200001 PM 19582867 ER EF